-- dump date 20140619_085442 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type YP_006776737.1 407479588 13700294 33..1436 1 NC_018658.1 COG0593 ATPase involved in DNA replication initiation; chromosomal replication initiation protein 1436 dnaA 13700294 dnaA Escherichia coli O104:H4 str. 2011C-3493 chromosomal replication initiation protein YP_006776737.1 33 D 1133852 CDS YP_006776738.1 407479589 13698670 1441..2541 1 NC_018658.1 COG0592 DNA polymerase sliding clamp subunit (PCNA homolog); DNA polymerase III subunit beta 2541 13698670 O3K_00010 Escherichia coli O104:H4 str. 2011C-3493 DNA polymerase III subunit beta YP_006776738.1 1441 D 1133852 CDS YP_006776739.1 407479590 13698671 2541..3614 1 NC_018658.1 COG1195 Recombinational DNA repair ATPase (RecF pathway); recombination protein F 3614 recF 13698671 recF Escherichia coli O104:H4 str. 2011C-3493 recombination protein F YP_006776739.1 2541 D 1133852 CDS YP_006776740.1 407479591 13698672 3643..6057 1 NC_018658.1 COG0187 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit; DNA gyrase subunit B 6057 gyrB 13698672 gyrB Escherichia coli O104:H4 str. 2011C-3493 DNA gyrase subunit B YP_006776740.1 3643 D 1133852 CDS YP_006776741.1 407479592 13698673 6077..6277 1 NC_018658.1 hypothetical protein 6277 13698673 O3K_00025 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776741.1 6077 D 1133852 CDS YP_006776742.1 407479593 13698674 6297..6695 1 NC_018658.1 COG3753 Uncharacterized protein conserved in bacteria; hypothetical protein 6695 13698674 O3K_00030 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776742.1 6297 D 1133852 CDS YP_006776743.1 407479594 13698675 6810..7622 1 NC_018658.1 COG0561 Predicted hydrolases of the HAD superfamily; sugar phosphate phosphatase 7622 13698675 O3K_00035 Escherichia coli O104:H4 str. 2011C-3493 sugar phosphate phosphatase YP_006776743.1 6810 D 1133852 CDS YP_006776744.1 407479595 13698676 complement(7668..8324) 1 NC_018658.1 hypothetical protein 8324 13698676 O3K_00040 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776744.1 7668 R 1133852 CDS YP_006776745.1 407479596 13698677 8602..9291 1 NC_018658.1 COG2186 Transcriptional regulators; putative DNA-binding transcriptional regulator 9291 13698677 O3K_00045 Escherichia coli O104:H4 str. 2011C-3493 putative DNA-binding transcriptional regulator YP_006776745.1 8602 D 1133852 CDS YP_006776746.1 407479597 13698678 9288..10166 1 NC_018658.1 COG3734 2-keto-3-deoxy-galactonokinase; 2-oxo-3-deoxygalactonate kinase 10166 13698678 O3K_00050 Escherichia coli O104:H4 str. 2011C-3493 2-oxo-3-deoxygalactonate kinase YP_006776746.1 9288 D 1133852 CDS YP_006776747.1 407479598 13698679 10150..10767 1 NC_018658.1 COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase; 2-dehydro-3-deoxy-6-phosphogalactonate aldolase 10767 13698679 O3K_00055 Escherichia coli O104:H4 str. 2011C-3493 2-dehydro-3-deoxy-6-phosphogalactonate aldolase YP_006776747.1 10150 D 1133852 CDS YP_006776748.1 407479599 13698680 10764..11912 1 NC_018658.1 COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily; galactonate dehydratase 11912 13698680 O3K_00060 Escherichia coli O104:H4 str. 2011C-3493 galactonate dehydratase YP_006776748.1 10764 D 1133852 CDS YP_006776749.1 407479600 13698681 12032..13324 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; D-galactonate transporter 13324 13698681 O3K_00065 Escherichia coli O104:H4 str. 2011C-3493 D-galactonate transporter YP_006776749.1 12032 D 1133852 CDS YP_006776750.1 407479601 13698682 complement(13321..14385) 1 NC_018658.1 COG0644 Dehydrogenases (flavoproteins); oxidoreductase 14385 13698682 O3K_00070 Escherichia coli O104:H4 str. 2011C-3493 oxidoreductase YP_006776750.1 13321 R 1133852 CDS YP_006776751.1 407479602 13698683 14486..15700 1 NC_018658.1 COG1506 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases; hypothetical protein 15700 13698683 O3K_00075 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776751.1 14486 D 1133852 CDS YP_006776752.1 407479603 13698684 complement(15702..16034) 1 NC_018658.1 COG5645 Predicted periplasmic lipoprotein; hypothetical protein 16034 13698684 O3K_00080 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776752.1 15702 R 1133852 CDS YP_006776753.1 407479604 13698685 16340..16753 1 NC_018658.1 COG0071 Molecular chaperone (small heat shock protein); heat shock protein IbpA 16753 13698685 O3K_00085 Escherichia coli O104:H4 str. 2011C-3493 heat shock protein IbpA YP_006776753.1 16340 D 1133852 CDS YP_006776754.1 407479605 13698686 16865..17293 1 NC_018658.1 COG0071 Molecular chaperone (small heat shock protein); heat shock chaperone IbpB 17293 13698686 O3K_00090 Escherichia coli O104:H4 str. 2011C-3493 heat shock chaperone IbpB YP_006776754.1 16865 D 1133852 CDS YP_006776755.1 407479606 13698687 17490..19151 1 NC_018658.1 COG2985 Predicted permease; transporter 19151 13698687 O3K_00095 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006776755.1 17490 D 1133852 CDS YP_006776756.1 407479607 13698688 complement(19148..19864) 1 NC_018658.1 COG2188 Transcriptional regulators; putative DNA-binding transcriptional regulator 19864 13698688 O3K_00100 Escherichia coli O104:H4 str. 2011C-3493 putative DNA-binding transcriptional regulator YP_006776756.1 19148 R 1133852 CDS YP_006776757.1 407479608 13698689 20160..21776 1 NC_018658.1 COG1263 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific; PTS system arbutin-like transporter subunit IIC 21776 13698689 O3K_00105 Escherichia coli O104:H4 str. 2011C-3493 PTS system arbutin-like transporter subunit IIC YP_006776757.1 20160 D 1133852 CDS YP_006776758.1 407479609 13698690 21776..22414 1 NC_018658.1 COG1486 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases; 6-phospho-beta-glucosidase 22414 13698690 O3K_00110 Escherichia coli O104:H4 str. 2011C-3493 6-phospho-beta-glucosidase YP_006776758.1 21776 D 1133852 CDS YP_006776759.1 407479610 13698691 22414..22590 1 NC_018658.1 COG1486 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases; glycoside hydrolase 22590 13698691 O3K_00115 Escherichia coli O104:H4 str. 2011C-3493 glycoside hydrolase YP_006776759.1 22414 D 1133852 CDS YP_006776760.1 407479611 13698692 complement(22587..23510) 1 NC_018658.1 COG2207 AraC-type DNA-binding domain-containing proteins; putative DNA-binding transcriptional regulator 23510 13698692 O3K_00120 Escherichia coli O104:H4 str. 2011C-3493 putative DNA-binding transcriptional regulator YP_006776760.1 22587 R 1133852 CDS YP_006776761.1 407479612 13698693 23647..25362 1 NC_018658.1 COG4146 Predicted symporter; transporter 25362 13698693 O3K_00125 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006776761.1 23647 D 1133852 CDS YP_006776762.1 407479613 13698694 25359..26852 1 NC_018658.1 COG3119 Arylsulfatase A and related enzymes; putative sulfatase/phosphatase 26852 13698694 O3K_00130 Escherichia coli O104:H4 str. 2011C-3493 putative sulfatase/phosphatase YP_006776762.1 25359 D 1133852 CDS YP_006776763.1 407479614 13698695 complement(26899..27348) 1 NC_018658.1 inner membrane protein 27348 13698695 O3K_00135 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006776763.1 26899 R 1133852 CDS YP_006776764.1 407479615 13698696 27457..27804 1 NC_018658.1 COG2149 Predicted membrane protein; inner membrane protein YidH 27804 13698696 O3K_00140 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YidH YP_006776764.1 27457 D 1133852 CDS YP_006776765.1 407479616 13698697 27794..28156 1 NC_018658.1 hypothetical protein 28156 13698697 O3K_00145 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776765.1 27794 D 1133852 CDS YP_006776766.1 407479617 13698698 28153..28650 1 NC_018658.1 COG0641 Arylsulfatase regulator (Fe-S oxidoreductase); transcriptional regulator 28650 13698698 O3K_00150 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator YP_006776766.1 28153 D 1133852 CDS YP_006776767.1 407479618 13698699 complement(28658..29842) 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; multidrug resistance protein D 29842 emrD 13698699 emrD Escherichia coli O104:H4 str. 2011C-3493 multidrug resistance protein D YP_006776767.1 28658 R 1133852 CDS YP_006776768.1 407479619 13698700 complement(30261..30350) 1 NC_018658.1 toxic peptide TisB 30350 13698700 O3K_00160 Escherichia coli O104:H4 str. 2011C-3493 toxic peptide TisB YP_006776768.1 30261 R 1133852 CDS YP_006776769.1 407479620 13698701 complement(30638..31120) 1 NC_018658.1 hypothetical protein 31120 13698701 O3K_00165 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776769.1 30638 R 1133852 CDS YP_006776770.1 407479621 13698702 31119..32807 1 NC_018658.1 COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; acetolactate synthase catalytic subunit 32807 13698702 O3K_00170 Escherichia coli O104:H4 str. 2011C-3493 acetolactate synthase catalytic subunit YP_006776770.1 31119 D 1133852 CDS YP_006776771.1 407479622 13698703 32811..33101 1 NC_018658.1 COG0440 Acetolactate synthase, small (regulatory) subunit; acetolactate synthase 1 regulatory subunit 33101 13698703 O3K_00175 Escherichia coli O104:H4 str. 2011C-3493 acetolactate synthase 1 regulatory subunit YP_006776771.1 32811 D 1133852 CDS YP_006776772.1 407479623 13698704 33176..33766 1 NC_018658.1 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; DNA-binding transcriptional activator UhpA 33766 13698704 O3K_00180 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional activator UhpA YP_006776772.1 33176 D 1133852 CDS YP_006776773.1 407479624 13698705 33766..35268 1 NC_018658.1 COG3851 Signal transduction histidine kinase, glucose-6-phosphate specific; sensory histidine kinase UhpB 35268 13698705 O3K_00185 Escherichia coli O104:H4 str. 2011C-3493 sensory histidine kinase UhpB YP_006776773.1 33766 D 1133852 CDS YP_006776774.1 407479625 13698706 35278..36597 1 NC_018658.1 COG2271 Sugar phosphate permease; regulatory protein UhpC 36597 13698706 O3K_00190 Escherichia coli O104:H4 str. 2011C-3493 regulatory protein UhpC YP_006776774.1 35278 D 1133852 CDS YP_006776775.1 407479626 13698707 36735..38126 1 NC_018658.1 COG2271 Sugar phosphate permease; sugar phosphate antiporter 38126 uhpT 13698707 uhpT Escherichia coli O104:H4 str. 2011C-3493 sugar phosphate antiporter YP_006776775.1 36735 D 1133852 CDS YP_006776776.1 407479627 13698708 complement(38171..39937) 1 NC_018658.1 COG1001 Adenine deaminase; cryptic adenine deaminase 39937 13698708 O3K_00200 Escherichia coli O104:H4 str. 2011C-3493 cryptic adenine deaminase YP_006776776.1 38171 R 1133852 CDS YP_006776777.1 407479628 13698709 40112..41446 1 NC_018658.1 COG2252 Permeases; hypothetical protein 41446 13698709 O3K_00205 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776777.1 40112 D 1133852 CDS YP_006776778.1 407479629 13698710 41499..41951 1 NC_018658.1 COG0442 Prolyl-tRNA synthetase; hypothetical protein 41951 13698710 O3K_00210 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776778.1 41499 D 1133852 CDS YP_006776779.1 407479630 13698711 42162..43346 1 NC_018658.1 COG2814 Arabinose efflux permease; ribonucleoside transporter 43346 nepI 13698711 nepI Escherichia coli O104:H4 str. 2011C-3493 ribonucleoside transporter YP_006776779.1 42162 D 1133852 CDS YP_006776780.1 407479631 13698712 complement(43387..43680) 1 NC_018658.1 hypothetical protein 43680 13698712 O3K_00220 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776780.1 43387 R 1133852 CDS YP_006776781.1 407479632 13698713 complement(43685..43804) 1 NC_018658.1 hypothetical protein 43804 13698713 O3K_00225 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776781.1 43685 R 1133852 CDS YP_006776782.1 407479633 13698714 43902..44720 1 NC_018658.1 COG1464 ABC-type metal ion transport system, periplasmic component/surface antigen; hypothetical protein 44720 13698714 O3K_00230 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776782.1 43902 D 1133852 CDS YP_006776783.1 407479634 13698715 complement(44724..45647) 1 NC_018658.1 COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; hypothetical protein 45647 13698715 O3K_00235 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776783.1 44724 R 1133852 CDS YP_006776784.1 407479635 13698716 complement(45758..46942) 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; sugar efflux system 46942 13698716 O3K_00240 Escherichia coli O104:H4 str. 2011C-3493 sugar efflux system YP_006776784.1 45758 R 1133852 CDS YP_006776785.1 407479636 13698717 complement(47324..47473) 1 NC_018658.1 COG3943 Virulence protein; hypothetical protein 47473 13698717 O3K_00245 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776785.1 47324 R 1133852 CDS YP_006776786.1 407479637 13698718 complement(47735..48580) 1 NC_018658.1 hypothetical protein 48580 13698718 O3K_00250 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776786.1 47735 R 1133852 CDS YP_006776787.1 407479638 13698719 complement(48665..48862) 1 NC_018658.1 hypothetical protein 48862 13698719 O3K_00255 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776787.1 48665 R 1133852 CDS YP_006776788.1 407479639 13698720 complement(48882..49370) 1 NC_018658.1 hypothetical protein 49370 13698720 O3K_00260 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776788.1 48882 R 1133852 CDS YP_006776789.1 407479640 13698721 complement(49367..49744) 1 NC_018658.1 hypothetical protein 49744 13698721 O3K_00265 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776789.1 49367 R 1133852 CDS YP_006776790.1 407479641 13698722 complement(49791..50168) 1 NC_018658.1 hypothetical protein 50168 13698722 O3K_00270 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776790.1 49791 R 1133852 CDS YP_006776791.1 407479642 13698723 complement(50218..50331) 1 NC_018658.1 hypothetical protein 50331 13698723 O3K_00275 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776791.1 50218 R 1133852 CDS YP_006776792.1 407479643 13698724 complement(50331..50552) 1 NC_018658.1 hypothetical protein 50552 13698724 O3K_00280 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776792.1 50331 R 1133852 CDS YP_006776793.1 407479644 13698725 complement(50615..51091) 1 NC_018658.1 COG2003 DNA repair proteins; putative DNA repair protein 51091 13698725 O3K_00285 Escherichia coli O104:H4 str. 2011C-3493 putative DNA repair protein YP_006776793.1 50615 R 1133852 CDS YP_006776794.1 407479645 13698726 complement(51107..51580) 1 NC_018658.1 hypothetical protein 51580 13698726 O3K_00290 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776794.1 51107 R 1133852 CDS YP_006776795.1 407479646 13698727 complement(51746..51919) 1 NC_018658.1 antirestriction protein 51919 13698727 O3K_00295 Escherichia coli O104:H4 str. 2011C-3493 antirestriction protein YP_006776795.1 51746 R 1133852 CDS YP_006776796.1 407479647 13698728 complement(51919..52737) 1 NC_018658.1 hypothetical protein 52737 13698728 O3K_00300 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776796.1 51919 R 1133852 CDS YP_006776797.1 407479648 13698729 complement(52892..53050) 1 NC_018658.1 hypothetical protein 53050 13698729 O3K_00305 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776797.1 52892 R 1133852 CDS YP_006776798.1 407479649 13698730 complement(53121..55967) 1 NC_018658.1 COG5295 Autotransporter adhesin; antigen 43 precursor (AG43, Fluffing protein) 55967 13698730 O3K_00310 Escherichia coli O104:H4 str. 2011C-3493 antigen 43 precursor (AG43, Fluffing protein) YP_006776798.1 53121 R 1133852 CDS YP_006776799.1 407479650 13698731 complement(56340..57212) 1 NC_018658.1 COG3596 Predicted GTPase; hypothetical protein 57212 13698731 O3K_00315 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776799.1 56340 R 1133852 CDS YP_006776800.1 407479651 13698732 complement(57311..58183) 1 NC_018658.1 hypothetical protein 58183 13698732 O3K_00320 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776800.1 57311 R 1133852 CDS YP_006776801.1 407479652 13698733 complement(59826..60038) 1 NC_018658.1 COG1484 DNA replication protein; IstB ATP binding domain-containing protein 60038 13698733 O3K_00325 Escherichia coli O104:H4 str. 2011C-3493 IstB ATP binding domain-containing protein YP_006776801.1 59826 R 1133852 CDS YP_006776802.1 407479653 13698734 60671..60868 1 NC_018658.1 hypothetical protein 60868 13698734 O3K_00330 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776802.1 60671 D 1133852 CDS YP_006776803.1 407479654 13698735 complement(60771..61379) 1 NC_018658.1 hypothetical protein 61379 13698735 O3K_00335 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776803.1 60771 R 1133852 CDS YP_006776804.1 407479655 13698736 complement(61468..61674) 1 NC_018658.1 COG3311 Predicted transcriptional regulator; putative Prophage CP4-57 regulatory protein 61674 13698736 O3K_00340 Escherichia coli O104:H4 str. 2011C-3493 putative Prophage CP4-57 regulatory protein YP_006776804.1 61468 R 1133852 CDS YP_006776805.1 407479656 13698737 62453..62593 1 NC_018658.1 hemolysin expression modulating protein 62593 13698737 O3K_00345 Escherichia coli O104:H4 str. 2011C-3493 hemolysin expression modulating protein YP_006776805.1 62453 D 1133852 CDS YP_006776806.1 407479657 13698738 62649..62795 1 NC_018658.1 hypothetical protein 62795 13698738 O3K_00350 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776806.1 62649 D 1133852 CDS YP_006776807.1 407479658 13698739 63337..63906 1 NC_018658.1 hypothetical protein 63906 13698739 O3K_00355 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776807.1 63337 D 1133852 CDS YP_006776808.1 407479659 13698740 64072..64455 1 NC_018658.1 COG0085 DNA-directed RNA polymerase, beta subunit/140 kD subunit; hypothetical protein 64455 13698740 O3K_00360 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776808.1 64072 D 1133852 CDS YP_006776809.1 407479660 13698741 64452..64661 1 NC_018658.1 hypothetical protein 64661 13698741 O3K_00365 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776809.1 64452 D 1133852 CDS YP_006776810.1 407479661 13698742 65208..65915 1 NC_018658.1 COG2801 Transposase and inactivated derivatives; transposase 65915 13698742 O3K_00370 Escherichia coli O104:H4 str. 2011C-3493 transposase YP_006776810.1 65208 D 1133852 CDS YP_006776811.1 407479662 13698743 65900..66760 1 NC_018658.1 COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; transporter permease 66760 13698743 O3K_00375 Escherichia coli O104:H4 str. 2011C-3493 transporter permease YP_006776811.1 65900 D 1133852 CDS YP_006776812.1 407479663 13698744 complement(66792..68066) 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; tetracycline efflux protein 68066 13698744 O3K_00380 Escherichia coli O104:H4 str. 2011C-3493 tetracycline efflux protein YP_006776812.1 66792 R 1133852 CDS YP_006776813.1 407479664 13698745 68070..68747 1 NC_018658.1 COG1309 Transcriptional regulator; tetracycline repressor protein 68747 13698745 O3K_00385 Escherichia coli O104:H4 str. 2011C-3493 tetracycline repressor protein YP_006776813.1 68070 D 1133852 CDS YP_006776814.1 407479665 13698746 complement(68779..69021) 1 NC_018658.1 transposase 69021 13698746 O3K_00390 Escherichia coli O104:H4 str. 2011C-3493 transposase YP_006776814.1 68779 R 1133852 CDS YP_006776815.1 407479666 13698747 68944..69108 1 NC_018658.1 hypothetical protein 69108 13698747 O3K_00395 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776815.1 68944 D 1133852 CDS YP_006776816.1 407479667 13698748 69317..69433 1 NC_018658.1 hypothetical protein 69433 13698748 O3K_00400 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776816.1 69317 D 1133852 CDS YP_006776817.1 407479668 13698749 69893..71005 1 NC_018658.1 COG3385 FOG: Transposase and inactivated derivatives; putative transposase insL for insertion sequence IS186 71005 13698749 O3K_00405 Escherichia coli O104:H4 str. 2011C-3493 putative transposase insL for insertion sequence IS186 YP_006776817.1 69893 D 1133852 CDS YP_006776818.1 407479669 13698750 complement(71373..71807) 1 NC_018658.1 COG0789 Predicted transcriptional regulators; putative transcriptional regulator MerR 71807 13698750 O3K_00410 Escherichia coli O104:H4 str. 2011C-3493 putative transcriptional regulator MerR YP_006776818.1 71373 R 1133852 CDS YP_006776819.1 407479670 13698751 71879..72229 1 NC_018658.1 putative mercuric transport protein 72229 13698751 O3K_00415 Escherichia coli O104:H4 str. 2011C-3493 putative mercuric transport protein YP_006776819.1 71879 D 1133852 CDS YP_006776820.1 407479671 13698752 72243..72518 1 NC_018658.1 COG2608 Copper chaperone; mercury resistance operon protein MerP 72518 13698752 O3K_00420 Escherichia coli O104:H4 str. 2011C-3493 mercury resistance operon protein MerP YP_006776820.1 72243 D 1133852 CDS YP_006776821.1 407479672 13698753 72554..72976 1 NC_018658.1 putative mercury transport protein MerC 72976 13698753 O3K_00425 Escherichia coli O104:H4 str. 2011C-3493 putative mercury transport protein MerC YP_006776821.1 72554 D 1133852 CDS YP_006776822.1 407479673 13698754 73028..74722 1 NC_018658.1 COG2608 Copper chaperone; putative mercuric reductase 74722 13698754 O3K_00430 Escherichia coli O104:H4 str. 2011C-3493 putative mercuric reductase YP_006776822.1 73028 D 1133852 CDS YP_006776823.1 407479674 13698755 74740..75102 1 NC_018658.1 COG0789 Predicted transcriptional regulators; transcriptional regulator MerD 75102 13698755 O3K_00435 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator MerD YP_006776823.1 74740 D 1133852 CDS YP_006776824.1 407479675 13698756 75099..75335 1 NC_018658.1 putative mercury resistance protein 75335 13698756 O3K_00440 Escherichia coli O104:H4 str. 2011C-3493 putative mercury resistance protein YP_006776824.1 75099 D 1133852 CDS YP_006776825.1 407479676 13698757 75332..76039 1 NC_018658.1 COG2200 FOG: EAL domain; hypothetical protein 76039 13698757 O3K_00445 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776825.1 75332 D 1133852 CDS YP_006776826.1 407479677 13698758 76078..77382 1 NC_018658.1 COG2801 Transposase and inactivated derivatives; TniA protein 77382 13698758 O3K_00450 Escherichia coli O104:H4 str. 2011C-3493 TniA protein YP_006776826.1 76078 D 1133852 CDS YP_006776827.1 407479678 13698759 77429..78133 1 NC_018658.1 COG3316 Transposase and inactivated derivatives; transposase 78133 13698759 O3K_00455 Escherichia coli O104:H4 str. 2011C-3493 transposase YP_006776827.1 77429 D 1133852 CDS YP_006776828.1 407479679 13698760 complement(78194..79030) 1 NC_018658.1 COG3570 Streptomycin 6-kinase; streptomycin phosphotransferase 79030 13698760 O3K_00460 Escherichia coli O104:H4 str. 2011C-3493 streptomycin phosphotransferase YP_006776828.1 78194 R 1133852 CDS YP_006776829.1 407479680 13698761 complement(79030..79833) 1 NC_018658.1 COG3231 Aminoglycoside phosphotransferase; hypothetical protein 79833 13698761 O3K_00465 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776829.1 79030 R 1133852 CDS YP_006776830.1 407479681 13698762 complement(79894..80709) 1 NC_018658.1 COG0294 Dihydropteroate synthase and related enzymes; dihydropteroate synthase 80709 13698762 O3K_00470 Escherichia coli O104:H4 str. 2011C-3493 dihydropteroate synthase YP_006776830.1 79894 R 1133852 CDS YP_006776831.1 407479682 13698763 complement(81017..81868) 1 NC_018658.1 replication protein C 81868 13698763 O3K_00475 Escherichia coli O104:H4 str. 2011C-3493 replication protein C YP_006776831.1 81017 R 1133852 CDS YP_006776832.1 407479683 13698764 complement(81855..82562) 1 NC_018658.1 COG3598 RecA-family ATPase; replication protein A 82562 13698764 O3K_00480 Escherichia coli O104:H4 str. 2011C-3493 replication protein A YP_006776832.1 81855 R 1133852 CDS YP_006776833.1 407479684 13698765 complement(82624..83328) 1 NC_018658.1 COG3316 Transposase and inactivated derivatives; transposase 83328 13698765 O3K_00485 Escherichia coli O104:H4 str. 2011C-3493 transposase YP_006776833.1 82624 R 1133852 CDS YP_006776834.1 407479685 13698766 83453..84157 1 NC_018658.1 COG3316 Transposase and inactivated derivatives; transposase 84157 13698766 O3K_00490 Escherichia coli O104:H4 str. 2011C-3493 transposase YP_006776834.1 83453 D 1133852 CDS YP_006776835.1 407479686 13698767 complement(84191..84970) 1 NC_018658.1 COG0294 Dihydropteroate synthase and related enzymes; dihydropteroate synthase 84970 13698767 O3K_00495 Escherichia coli O104:H4 str. 2011C-3493 dihydropteroate synthase YP_006776835.1 84191 R 1133852 CDS YP_006776836.1 407479687 13698768 complement(84964..85311) 1 NC_018658.1 COG2076 Membrane transporters of cations and cationic drugs; multidrug efflux protein 85311 13698768 O3K_00500 Escherichia coli O104:H4 str. 2011C-3493 multidrug efflux protein YP_006776836.1 84964 R 1133852 CDS YP_006776837.1 407479688 13698769 complement(85541..86014) 1 NC_018658.1 COG0262 Dihydrofolate reductase; dihydrofolate reductase 86014 13698769 O3K_00505 Escherichia coli O104:H4 str. 2011C-3493 dihydrofolate reductase YP_006776837.1 85541 R 1133852 CDS YP_006776838.1 407479689 13698770 86172..87185 1 NC_018658.1 COG0582 Integrase; integrase/recombinase 87185 13698770 O3K_00510 Escherichia coli O104:H4 str. 2011C-3493 integrase/recombinase YP_006776838.1 86172 D 1133852 CDS YP_006776839.1 407479690 13698771 complement(87144..87323) 1 NC_018658.1 transcriptional regulator 87323 13698771 O3K_00515 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator YP_006776839.1 87144 R 1133852 CDS YP_006776840.1 407479691 13698772 87538..87738 1 NC_018658.1 modulator protein 87738 13698772 O3K_00520 Escherichia coli O104:H4 str. 2011C-3493 modulator protein YP_006776840.1 87538 D 1133852 CDS YP_006776841.1 407479692 13698773 87864..88424 1 NC_018658.1 COG1961 Site-specific recombinases, DNA invertase Pin homologs; Tn21 resolvase 88424 13698773 O3K_00525 Escherichia coli O104:H4 str. 2011C-3493 Tn21 resolvase YP_006776841.1 87864 D 1133852 CDS YP_006776842.1 407479693 13698774 88427..91393 1 NC_018658.1 COG4644 Transposase and inactivated derivatives, TnpA family; transposase TnpA, Tn21 91393 13698774 O3K_00530 Escherichia coli O104:H4 str. 2011C-3493 transposase TnpA, Tn21 YP_006776842.1 88427 D 1133852 CDS YP_006776843.1 407479694 13698775 91460..91549 1 NC_018658.1 acetyltransferase 91549 13698775 O3K_00535 Escherichia coli O104:H4 str. 2011C-3493 acetyltransferase YP_006776843.1 91460 D 1133852 CDS YP_006776844.1 407479695 13698776 91583..91858 1 NC_018658.1 COG3677 Transposase and inactivated derivatives; InsA 91858 13698776 O3K_00540 Escherichia coli O104:H4 str. 2011C-3493 InsA YP_006776844.1 91583 D 1133852 CDS YP_006776845.1 407479696 13698777 91777..92280 1 NC_018658.1 COG1662 Transposase and inactivated derivatives, IS1 family; transposase InsB IS1 92280 13698777 O3K_00545 Escherichia coli O104:H4 str. 2011C-3493 transposase InsB IS1 YP_006776845.1 91777 D 1133852 CDS YP_006776846.1 407479697 13698778 complement(92399..93583) 1 NC_018658.1 COG0582 Integrase; hypothetical protein 93583 13698778 O3K_00550 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776846.1 92399 R 1133852 CDS YP_006776847.1 407479698 13698780 94270..95652 1 NC_018658.1 COG2211 Na+/melibiose symporter and related transporters; transporter 95652 13698780 O3K_00555 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006776847.1 94270 D 1133852 CDS YP_006776848.1 407479699 13698781 95662..97980 1 NC_018658.1 COG1501 Alpha-glucosidases, family 31 of glycosyl hydrolases; putative alpha-glucosidase 97980 13698781 O3K_00560 Escherichia coli O104:H4 str. 2011C-3493 putative alpha-glucosidase YP_006776848.1 95662 D 1133852 CDS YP_006776849.1 407479700 13698782 complement(98033..99742) 1 NC_018658.1 hypothetical protein 99742 13698782 O3K_00565 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776849.1 98033 R 1133852 CDS YP_006776850.1 407479701 13698783 complement(99863..101254) 1 NC_018658.1 COG2233 Xanthine/uracil permeases; purine permease yicE 101254 13698783 O3K_00570 Escherichia coli O104:H4 str. 2011C-3493 purine permease yicE YP_006776850.1 99863 R 1133852 CDS YP_006776851.1 407479702 13698784 101534..102739 1 NC_018658.1 COG0786 Na+/glutamate symporter; sodium/glutamate symporter 102739 13698784 O3K_00575 Escherichia coli O104:H4 str. 2011C-3493 sodium/glutamate symporter YP_006776851.1 101534 D 1133852 CDS YP_006776852.1 407479703 13698785 complement(102905..104986) 1 NC_018658.1 COG1200 RecG-like helicase; ATP-dependent DNA helicase RecG 104986 13698785 O3K_00580 Escherichia coli O104:H4 str. 2011C-3493 ATP-dependent DNA helicase RecG YP_006776852.1 102905 R 1133852 CDS YP_006776853.1 407479704 13698786 complement(104992..105681) 1 NC_018658.1 COG0566 rRNA methylases; tRNA guanosine-2'-O-methyltransferase 105681 13698786 O3K_00585 Escherichia coli O104:H4 str. 2011C-3493 tRNA guanosine-2'-O-methyltransferase YP_006776853.1 104992 R 1133852 CDS YP_006776854.1 407479705 13698787 complement(105688..107796) 1 NC_018658.1 COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases; bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 107796 13698787 O3K_00590 Escherichia coli O104:H4 str. 2011C-3493 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase YP_006776854.1 105688 R 1133852 CDS YP_006776855.1 407479706 13698788 complement(107815..108090) 1 NC_018658.1 COG1758 DNA-directed RNA polymerase, subunit K/omega; DNA-directed RNA polymerase subunit omega 108090 rpoZ 13698788 rpoZ Escherichia coli O104:H4 str. 2011C-3493 DNA-directed RNA polymerase subunit omega YP_006776855.1 107815 R 1133852 CDS YP_006776856.1 407479707 13698789 complement(108145..108768) 1 NC_018658.1 COG0194 Guanylate kinase; guanylate kinase 108768 gmk 13698789 gmk Escherichia coli O104:H4 str. 2011C-3493 guanylate kinase YP_006776856.1 108145 R 1133852 CDS YP_006776857.1 407479708 13698790 109026..110708 1 NC_018658.1 COG0272 NAD-dependent DNA ligase (contains BRCT domain type II); NAD-dependent DNA ligase LigB 110708 ligB 13698790 ligB Escherichia coli O104:H4 str. 2011C-3493 NAD-dependent DNA ligase LigB YP_006776857.1 109026 D 1133852 CDS YP_006776858.1 407479709 13698791 complement(110705..111322) 1 NC_018658.1 COG2860 Predicted membrane protein; hypothetical protein 111322 13698791 O3K_00610 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776858.1 110705 R 1133852 CDS YP_006776859.1 407479710 13698792 complement(111614..112438) 1 NC_018658.1 DNA-damage-inducible protein D 112438 dinD 13698792 dinD Escherichia coli O104:H4 str. 2011C-3493 DNA-damage-inducible protein D YP_006776859.1 111614 R 1133852 CDS YP_006776860.1 407479711 13698793 complement(112659..113522) 1 NC_018658.1 COG1561 Uncharacterized stress-induced protein; hypothetical protein 113522 13698793 O3K_00620 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776860.1 112659 R 1133852 CDS YP_006776861.1 407479712 13698794 113649..114365 1 NC_018658.1 COG0689 RNase PH; ribonuclease PH 114365 rph 13698794 rph Escherichia coli O104:H4 str. 2011C-3493 ribonuclease PH YP_006776861.1 113649 D 1133852 CDS YP_006776862.1 407479713 13698795 114431..115072 1 NC_018658.1 COG0461 Orotate phosphoribosyltransferase; orotate phosphoribosyltransferase 115072 pyrE 13698795 pyrE Escherichia coli O104:H4 str. 2011C-3493 orotate phosphoribosyltransferase YP_006776862.1 114431 D 1133852 CDS YP_006776863.1 407479714 13698796 complement(115109..115705) 1 NC_018658.1 COG1309 Transcriptional regulator; division inhibitor protein 115705 slmA 13698796 slmA Escherichia coli O104:H4 str. 2011C-3493 division inhibitor protein YP_006776863.1 115109 R 1133852 CDS YP_006776864.1 407479715 13698797 complement(115812..116267) 1 NC_018658.1 COG0756 dUTPase; deoxyuridine 5'-triphosphate nucleotidohydrolase 116267 dut 13698797 dut Escherichia coli O104:H4 str. 2011C-3493 deoxyuridine 5'-triphosphate nucleotidohydrolase YP_006776864.1 115812 R 1133852 CDS YP_006776865.1 407479716 13698798 complement(116248..117468) 1 NC_018658.1 COG0452 Phosphopantothenoylcysteine synthetase/decarboxylase; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase 117468 13698798 O3K_00645 Escherichia coli O104:H4 str. 2011C-3493 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase YP_006776865.1 116248 R 1133852 CDS YP_006776866.1 407479717 13698799 117640..118308 1 NC_018658.1 COG2003 DNA repair proteins; hypothetical protein 118308 13698799 O3K_00650 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776866.1 117640 D 1133852 CDS YP_006776867.1 407479718 13698800 118525..118761 1 NC_018658.1 COG0227 Ribosomal protein L28; 50S ribosomal protein L28 118761 rpmB 13698800 rpmB Escherichia coli O104:H4 str. 2011C-3493 50S ribosomal protein L28 YP_006776867.1 118525 D 1133852 CDS YP_006776868.1 407479719 13698801 118782..118949 1 NC_018658.1 COG0267 Ribosomal protein L33; 50S ribosomal protein L33 118949 rpmG 13698801 rpmG Escherichia coli O104:H4 str. 2011C-3493 50S ribosomal protein L33 YP_006776868.1 118782 D 1133852 CDS YP_006776869.1 407479720 13698802 119047..119856 1 NC_018658.1 COG0266 Formamidopyrimidine-DNA glycosylase; formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase 119856 13698802 O3K_00665 Escherichia coli O104:H4 str. 2011C-3493 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase YP_006776869.1 119047 D 1133852 CDS YP_006776870.1 407479721 13698803 complement(119895..120374) 1 NC_018658.1 COG0669 Phosphopantetheine adenylyltransferase; phosphopantetheine adenylyltransferase 120374 coaD 13698803 coaD Escherichia coli O104:H4 str. 2011C-3493 phosphopantetheine adenylyltransferase YP_006776870.1 119895 R 1133852 CDS YP_006776871.1 407479722 13698804 complement(120382..121659) 1 NC_018658.1 COG1519 3-deoxy-D-manno-octulosonic-acid transferase; 3-deoxy-D-manno-octulosonic-acid transferase 121659 13698804 O3K_00675 Escherichia coli O104:H4 str. 2011C-3493 3-deoxy-D-manno-octulosonic-acid transferase YP_006776871.1 120382 R 1133852 CDS YP_006776872.1 407479723 13698805 122072..123130 1 NC_018658.1 COG0859 ADP-heptose:LPS heptosyltransferase; lipopolysaccharide core biosynthesis protein 123130 13698805 O3K_00680 Escherichia coli O104:H4 str. 2011C-3493 lipopolysaccharide core biosynthesis protein YP_006776872.1 122072 D 1133852 CDS YP_006776873.1 407479724 13698806 123127..124251 1 NC_018658.1 COG0438 Glycosyltransferase; glucosyltransferase I RfaG 124251 13698806 O3K_00685 Escherichia coli O104:H4 str. 2011C-3493 glucosyltransferase I RfaG YP_006776873.1 123127 D 1133852 CDS YP_006776874.1 407479725 13698807 124244..125041 1 NC_018658.1 COG0515 Serine/threonine protein kinase; lipopolysaccharide core heptose(I) kinase RfaP 125041 13698807 O3K_00690 Escherichia coli O104:H4 str. 2011C-3493 lipopolysaccharide core heptose(I) kinase RfaP YP_006776874.1 124244 D 1133852 CDS YP_006776875.1 407479726 13698808 125084..126091 1 NC_018658.1 COG1442 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases; lipopolysaccharide 1,3-galactosyltransferase 126091 13698808 O3K_00695 Escherichia coli O104:H4 str. 2011C-3493 lipopolysaccharide 1,3-galactosyltransferase YP_006776875.1 125084 D 1133852 CDS YP_006776876.1 407479727 13698809 126117..126824 1 NC_018658.1 COG0515 Serine/threonine protein kinase; lipopolysaccharide core biosynthesis protein 126824 13698809 O3K_00700 Escherichia coli O104:H4 str. 2011C-3493 lipopolysaccharide core biosynthesis protein YP_006776876.1 126117 D 1133852 CDS YP_006776877.1 407479728 13698810 126849..127862 1 NC_018658.1 COG1442 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases; lipopolysaccharide 1,2-glucosyltransferase 127862 13698810 O3K_00705 Escherichia coli O104:H4 str. 2011C-3493 lipopolysaccharide 1,2-glucosyltransferase YP_006776877.1 126849 D 1133852 CDS YP_006776878.1 407479729 13698811 127871..129013 1 NC_018658.1 COG0438 Glycosyltransferase; lipopolysaccharide 1,2-N-acetylglucosaminetransferase 129013 13698811 O3K_00710 Escherichia coli O104:H4 str. 2011C-3493 lipopolysaccharide 1,2-N-acetylglucosaminetransferase YP_006776878.1 127871 D 1133852 CDS YP_006776879.1 407479730 13698812 complement(129049..130257) 1 NC_018658.1 COG3307 Lipid A core - O-antigen ligase and related enzymes; O-antigen ligase RfaL 130257 13698812 O3K_00715 Escherichia coli O104:H4 str. 2011C-3493 O-antigen ligase RfaL YP_006776879.1 129049 R 1133852 CDS YP_006776880.1 407479731 13698813 complement(130254..131246) 1 NC_018658.1 COG0859 ADP-heptose:LPS heptosyltransferase; ADP-heptose--LPS heptosyltransferase 131246 13698813 O3K_00720 Escherichia coli O104:H4 str. 2011C-3493 ADP-heptose--LPS heptosyltransferase YP_006776880.1 130254 R 1133852 CDS YP_006776881.1 407479732 13698814 complement(131250..132296) 1 NC_018658.1 COG0859 ADP-heptose:LPS heptosyltransferase; ADP-heptose--LPS heptosyltransferase 132296 13698814 O3K_00725 Escherichia coli O104:H4 str. 2011C-3493 ADP-heptose--LPS heptosyltransferase YP_006776881.1 131250 R 1133852 CDS YP_006776882.1 407479733 13698815 complement(132306..133238) 1 NC_018658.1 COG0451 Nucleoside-diphosphate-sugar epimerases; ADP-L-glycero-D-manno-heptose-6-epimerase 133238 rfaD 13698815 rfaD Escherichia coli O104:H4 str. 2011C-3493 ADP-L-glycero-D-manno-heptose-6-epimerase YP_006776882.1 132306 R 1133852 CDS YP_006776883.1 407479734 13698816 133542..134399 1 NC_018658.1 hypothetical protein 134399 13698816 O3K_00735 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776883.1 133542 D 1133852 CDS YP_006776884.1 407479735 13698817 134674..135870 1 NC_018658.1 COG0156 7-keto-8-aminopelargonate synthetase and related enzymes; 2-amino-3-ketobutyrate coenzyme A ligase 135870 13698817 O3K_00740 Escherichia coli O104:H4 str. 2011C-3493 2-amino-3-ketobutyrate coenzyme A ligase YP_006776884.1 134674 D 1133852 CDS YP_006776885.1 407479736 13698818 135880..136905 1 NC_018658.1 COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases; L-threonine 3-dehydrogenase 136905 tdh 13698818 tdh Escherichia coli O104:H4 str. 2011C-3493 L-threonine 3-dehydrogenase YP_006776885.1 135880 D 1133852 CDS YP_006776886.1 407479737 13698819 137144..138178 1 NC_018658.1 COG0463 Glycosyltransferases involved in cell wall biogenesis; putative glycosyl transferase 138178 13698819 O3K_00750 Escherichia coli O104:H4 str. 2011C-3493 putative glycosyl transferase YP_006776886.1 137144 D 1133852 CDS YP_006776887.1 407479738 13698820 complement(138165..139124) 1 NC_018658.1 COG2861 Uncharacterized protein conserved in bacteria; putative polysaccharide deacetylase 139124 13698820 O3K_00755 Escherichia coli O104:H4 str. 2011C-3493 putative polysaccharide deacetylase YP_006776887.1 138165 R 1133852 CDS YP_006776888.1 407479739 13698821 complement(139128..140411) 1 NC_018658.1 COG4942 Membrane-bound metallopeptidase; AmiB activator 140411 13698821 O3K_00760 Escherichia coli O104:H4 str. 2011C-3493 AmiB activator YP_006776888.1 139128 R 1133852 CDS YP_006776889.1 407479740 13698822 complement(140421..141965) 1 NC_018658.1 COG0696 Phosphoglyceromutase; phosphoglyceromutase 141965 13698822 O3K_00765 Escherichia coli O104:H4 str. 2011C-3493 phosphoglyceromutase YP_006776889.1 140421 R 1133852 CDS YP_006776890.1 407479741 13698823 142210..142641 1 NC_018658.1 COG0607 Rhodanese-related sulfurtransferase; hypothetical protein 142641 13698823 O3K_00770 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776890.1 142210 D 1133852 CDS YP_006776891.1 407479742 13698824 142783..143034 1 NC_018658.1 COG0695 Glutaredoxin and related proteins; glutaredoxin 3 143034 13698824 O3K_00775 Escherichia coli O104:H4 str. 2011C-3493 glutaredoxin 3 YP_006776891.1 142783 D 1133852 CDS YP_006776892.1 407479743 13698825 143097..143564 1 NC_018658.1 COG1952 Preprotein translocase subunit SecB; preprotein translocase subunit SecB 143564 13698825 O3K_00780 Escherichia coli O104:H4 str. 2011C-3493 preprotein translocase subunit SecB YP_006776892.1 143097 D 1133852 CDS YP_006776893.1 407479744 13698826 143564..144583 1 NC_018658.1 COG0240 Glycerol-3-phosphate dehydrogenase; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 144583 gpsA 13698826 gpsA Escherichia coli O104:H4 str. 2011C-3493 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase YP_006776893.1 143564 D 1133852 CDS YP_006776894.1 407479745 13698827 144663..145484 1 NC_018658.1 COG1045 Serine acetyltransferase; serine acetyltransferase 145484 cysE 13698827 cysE Escherichia coli O104:H4 str. 2011C-3493 serine acetyltransferase YP_006776894.1 144663 D 1133852 CDS YP_006776895.1 407479746 13698828 complement(145537..146010) 1 NC_018658.1 COG0219 Predicted rRNA methylase (SpoU class); putative rRNA methylase 146010 13698828 O3K_00795 Escherichia coli O104:H4 str. 2011C-3493 putative rRNA methylase YP_006776895.1 145537 R 1133852 CDS YP_006776896.1 407479747 13698829 complement(146196..147386) 1 NC_018658.1 COG1304 L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases; L-lactate dehydrogenase 147386 lldD 13698829 lldD Escherichia coli O104:H4 str. 2011C-3493 L-lactate dehydrogenase YP_006776896.1 146196 R 1133852 CDS YP_006776897.1 407479748 13698830 complement(147383..148159) 1 NC_018658.1 COG2186 Transcriptional regulators; DNA-binding transcriptional repressor LldR 148159 13698830 O3K_00805 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional repressor LldR YP_006776897.1 147383 R 1133852 CDS YP_006776898.1 407479749 13698831 complement(148159..149814) 1 NC_018658.1 COG1620 L-lactate permease; L-lactate permease 149814 13698831 O3K_00810 Escherichia coli O104:H4 str. 2011C-3493 L-lactate permease YP_006776898.1 148159 R 1133852 CDS YP_006776899.1 407479750 13698832 complement(150183..155033) 1 NC_018658.1 COG5295 Autotransporter adhesin; adhesin 155033 13698832 O3K_00815 Escherichia coli O104:H4 str. 2011C-3493 adhesin YP_006776899.1 150183 R 1133852 CDS YP_006776900.1 407479751 13698833 complement(155077..155760) 1 NC_018658.1 hypothetical protein 155760 13698833 O3K_00820 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776900.1 155077 R 1133852 CDS YP_006776901.1 407479752 13698834 complement(156304..156666) 1 NC_018658.1 hypothetical protein 156666 13698834 O3K_00825 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776901.1 156304 R 1133852 CDS YP_006776902.1 407479753 13698835 156951..157160 1 NC_018658.1 hypothetical protein 157160 13698835 O3K_00830 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776902.1 156951 D 1133852 CDS YP_006776903.1 407479754 13698836 complement(157172..157759) 1 NC_018658.1 COG3722 Transcriptional regulator; mannitol repressor protein 157759 mtlR 13698836 mtlR Escherichia coli O104:H4 str. 2011C-3493 mannitol repressor protein YP_006776903.1 157172 R 1133852 CDS YP_006776904.1 407479755 13698837 complement(157759..158907) 1 NC_018658.1 COG0246 Mannitol-1-phosphate/altronate dehydrogenases; mannitol-1-phosphate 5-dehydrogenase 158907 13698837 O3K_00840 Escherichia coli O104:H4 str. 2011C-3493 mannitol-1-phosphate 5-dehydrogenase YP_006776904.1 157759 R 1133852 CDS YP_006776905.1 407479756 13698838 complement(159137..161050) 1 NC_018658.1 COG2213 Phosphotransferase system, mannitol-specific IIBC component; PTS system mannitol-specific transporter subunit IICBA 161050 13698838 O3K_00845 Escherichia coli O104:H4 str. 2011C-3493 PTS system mannitol-specific transporter subunit IICBA YP_006776905.1 159137 R 1133852 CDS YP_006776906.1 407479757 13698839 161587..161949 1 NC_018658.1 hypothetical protein 161949 13698839 O3K_00850 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776906.1 161587 D 1133852 CDS YP_006776907.1 407479758 13698840 161952..163088 1 NC_018658.1 COG1566 Multidrug resistance efflux pump; hypothetical protein 163088 13698840 O3K_00855 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776907.1 161952 D 1133852 CDS YP_006776908.1 407479759 13698841 complement(164687..165148) 1 NC_018658.1 COG0790 FOG: TPR repeat, SEL1 subfamily; hypothetical protein 165148 13698841 O3K_00860 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776908.1 164687 R 1133852 CDS YP_006776909.1 407479760 13698842 complement(165160..166104) 1 NC_018658.1 COG3209 Rhs family protein; rhsA core protein with extension 166104 13698842 O3K_00865 Escherichia coli O104:H4 str. 2011C-3493 rhsA core protein with extension YP_006776909.1 165160 R 1133852 CDS YP_006776910.1 407479761 13698843 complement(166146..166988) 1 NC_018658.1 COG1413 FOG: HEAT repeat; putative lyase 166988 13698843 O3K_00870 Escherichia coli O104:H4 str. 2011C-3493 putative lyase YP_006776910.1 166146 R 1133852 CDS YP_006776911.1 407479762 13698844 complement(167093..167476) 1 NC_018658.1 hypothetical protein 167476 13698844 O3K_00875 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776911.1 167093 R 1133852 CDS YP_006776912.1 407479763 13698845 complement(167718..171683) 1 NC_018658.1 COG3209 Rhs family protein; rhsB element core protein RshB 171683 13698845 O3K_00880 Escherichia coli O104:H4 str. 2011C-3493 rhsB element core protein RshB YP_006776912.1 167718 R 1133852 CDS YP_006776913.1 407479764 13698846 171912..172520 1 NC_018658.1 COG0625 Glutathione S-transferase; putative glutathione S-transferase 172520 13698846 O3K_00885 Escherichia coli O104:H4 str. 2011C-3493 putative glutathione S-transferase YP_006776913.1 171912 D 1133852 CDS YP_006776914.1 407479765 13698847 172618..174009 1 NC_018658.1 COG1921 Selenocysteine synthase [seryl-tRNASer selenium transferase]; selenocysteine synthase 174009 13698847 O3K_00890 Escherichia coli O104:H4 str. 2011C-3493 selenocysteine synthase YP_006776914.1 172618 D 1133852 CDS YP_006776915.1 407479766 13698848 174006..175850 1 NC_018658.1 COG3276 Selenocysteine-specific translation elongation factor; selenocysteinyl-tRNA-specific translation factor 175850 13698848 O3K_00895 Escherichia coli O104:H4 str. 2011C-3493 selenocysteinyl-tRNA-specific translation factor YP_006776915.1 174006 D 1133852 CDS YP_006776916.1 407479767 13698849 176040..177191 1 NC_018658.1 COG1454 Alcohol dehydrogenase, class IV; alcohol dehydrogenase 177191 13698849 O3K_00900 Escherichia coli O104:H4 str. 2011C-3493 alcohol dehydrogenase YP_006776916.1 176040 D 1133852 CDS YP_006776917.1 407479768 13698850 177356..178894 1 NC_018658.1 COG1012 NAD-dependent aldehyde dehydrogenases; aldehyde dehydrogenase 178894 13698850 O3K_00905 Escherichia coli O104:H4 str. 2011C-3493 aldehyde dehydrogenase YP_006776917.1 177356 D 1133852 CDS YP_006776918.1 407479769 13698851 complement(179113..179325) 1 NC_018658.1 hypothetical protein 179325 13698851 O3K_00910 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776918.1 179113 R 1133852 CDS YP_006776919.1 407479770 13698852 179439..179762 1 NC_018658.1 hypothetical protein 179762 13698852 O3K_00915 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776919.1 179439 D 1133852 CDS YP_006776920.1 407479771 13698853 179768..180904 1 NC_018658.1 COG1566 Multidrug resistance efflux pump; efflux pump membrane protein 180904 13698853 O3K_00920 Escherichia coli O104:H4 str. 2011C-3493 efflux pump membrane protein YP_006776920.1 179768 D 1133852 CDS YP_006776921.1 407479772 13698854 complement(180901..181875) 1 NC_018658.1 COG0583 Transcriptional regulator; putative DNA-binding transcriptional regulator 181875 13698854 O3K_00925 Escherichia coli O104:H4 str. 2011C-3493 putative DNA-binding transcriptional regulator YP_006776921.1 180901 R 1133852 CDS YP_006776922.1 407479773 13698855 181999..182739 1 NC_018658.1 COG3713 Outer membrane protein V; hypothetical protein 182739 13698855 O3K_00930 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776922.1 181999 D 1133852 CDS YP_006776923.1 407479774 13698856 complement(183086..183781) 1 NC_018658.1 COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases; L-ribulose-5-phosphate 4-epimerase 183781 sgbE 13698856 sgbE Escherichia coli O104:H4 str. 2011C-3493 L-ribulose-5-phosphate 4-epimerase YP_006776923.1 183086 R 1133852 CDS YP_006776924.1 407479775 13698857 complement(183775..184635) 1 NC_018658.1 COG3623 Putative L-xylulose-5-phosphate 3-epimerase; putative L-xylulose 5-phosphate 3-epimerase 184635 13698857 O3K_00940 Escherichia coli O104:H4 str. 2011C-3493 putative L-xylulose 5-phosphate 3-epimerase YP_006776924.1 183775 R 1133852 CDS YP_006776925.1 407479776 13698858 complement(184628..185290) 1 NC_018658.1 COG0269 3-hexulose-6-phosphate synthase and related proteins; 3-keto-L-gulonate-6-phosphate decarboxylase 185290 sgbH 13698858 sgbH Escherichia coli O104:H4 str. 2011C-3493 3-keto-L-gulonate-6-phosphate decarboxylase YP_006776925.1 184628 R 1133852 CDS YP_006776926.1 407479777 13698859 complement(185287..186783) 1 NC_018658.1 COG1070 Sugar (pentulose and hexulose) kinases; L-xylulose kinase 186783 13698859 O3K_00950 Escherichia coli O104:H4 str. 2011C-3493 L-xylulose kinase YP_006776926.1 185287 R 1133852 CDS YP_006776927.1 407479778 13698860 complement(186787..187773) 1 NC_018658.1 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component; transporter 187773 13698860 O3K_00955 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006776927.1 186787 R 1133852 CDS YP_006776928.1 407479779 13698861 complement(187786..189063) 1 NC_018658.1 COG1593 TRAP-type C4-dicarboxylate transport system, large permease component; L-dehydroascorbate transporter large permease subunit 189063 13698861 O3K_00960 Escherichia coli O104:H4 str. 2011C-3493 L-dehydroascorbate transporter large permease subunit YP_006776928.1 187786 R 1133852 CDS YP_006776929.1 407479780 13698862 complement(189066..189539) 1 NC_018658.1 COG3090 TRAP-type C4-dicarboxylate transport system, small permease component; 2,3-diketo-L-gulonate TRAP transporter small permease 189539 13698862 O3K_00965 Escherichia coli O104:H4 str. 2011C-3493 2,3-diketo-L-gulonate TRAP transporter small permease YP_006776929.1 189066 R 1133852 CDS YP_006776930.1 407479781 13698863 complement(189657..190124) 1 NC_018658.1 COG2731 Beta-galactosidase, beta subunit; hypothetical protein 190124 13698863 O3K_00970 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776930.1 189657 R 1133852 CDS YP_006776931.1 407479782 13698864 complement(190136..191134) 1 NC_018658.1 COG2055 Malate/L-lactate dehydrogenases; 2,3-diketo-L-gulonate reductase 191134 13698864 O3K_00975 Escherichia coli O104:H4 str. 2011C-3493 2,3-diketo-L-gulonate reductase YP_006776931.1 190136 R 1133852 CDS YP_006776932.1 407479783 13698865 191335..192183 1 NC_018658.1 COG1414 Transcriptional regulator; putative DNA-binding transcriptional repressor 192183 13698865 O3K_00980 Escherichia coli O104:H4 str. 2011C-3493 putative DNA-binding transcriptional repressor YP_006776932.1 191335 D 1133852 CDS YP_006776933.1 407479784 13698866 192285..192758 1 NC_018658.1 COG1142 Fe-S-cluster-containing hydrogenase components 2; 4Fe-4S binding protein 192758 13698866 O3K_00985 Escherichia coli O104:H4 str. 2011C-3493 4Fe-4S binding protein YP_006776933.1 192285 D 1133852 CDS YP_006776934.1 407479785 13698867 complement(192778..192906) 1 NC_018658.1 hypothetical protein 192906 13698867 O3K_00990 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776934.1 192778 R 1133852 CDS YP_006776935.1 407479786 13698868 complement(192910..194163) 1 NC_018658.1 COG3977 Alanine-alpha-ketoisovalerate (or valine-pyruvate) aminotransferase; valine--pyruvate transaminase 194163 avtA 13698868 avtA Escherichia coli O104:H4 str. 2011C-3493 valine--pyruvate transaminase YP_006776935.1 192910 R 1133852 CDS YP_006776936.1 407479787 13698869 196690..197514 1 NC_018658.1 COG2992 Uncharacterized FlgJ-related protein; hypothetical protein 197514 13698869 O3K_01010 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776936.1 196690 D 1133852 CDS YP_006776937.1 407479788 13698870 complement(197710..198888) 1 NC_018658.1 COG1609 Transcriptional regulators; DNA-binding transcriptional activator, xylose-binding protein 198888 13698870 O3K_01015 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional activator, xylose-binding protein YP_006776937.1 197710 R 1133852 CDS YP_006776938.1 407479789 13698871 complement(198966..200147) 1 NC_018658.1 COG4214 ABC-type xylose transport system, permease component; D-xylose ABC transporter permease 200147 13698871 O3K_01020 Escherichia coli O104:H4 str. 2011C-3493 D-xylose ABC transporter permease YP_006776938.1 198966 R 1133852 CDS YP_006776939.1 407479790 13698872 complement(200125..201666) 1 NC_018658.1 COG1129 ABC-type sugar transport system, ATPase component; xylose transporter ATP-binding subunit 201666 13698872 O3K_01025 Escherichia coli O104:H4 str. 2011C-3493 xylose transporter ATP-binding subunit YP_006776939.1 200125 R 1133852 CDS YP_006776940.1 407479791 13698873 complement(201744..202736) 1 NC_018658.1 COG4213 ABC-type xylose transport system, periplasmic component; D-xylose transporter subunit XylF 202736 xylF 13698873 xylF Escherichia coli O104:H4 str. 2011C-3493 D-xylose transporter subunit XylF YP_006776940.1 201744 R 1133852 CDS YP_006776941.1 407479792 13698874 203102..204424 1 NC_018658.1 COG2115 Xylose isomerase; xylose isomerase 204424 13698874 O3K_01035 Escherichia coli O104:H4 str. 2011C-3493 xylose isomerase YP_006776941.1 203102 D 1133852 CDS YP_006776942.1 407479793 13698875 204496..205950 1 NC_018658.1 COG1070 Sugar (pentulose and hexulose) kinases; xylulokinase 205950 13698875 O3K_01040 Escherichia coli O104:H4 str. 2011C-3493 xylulokinase YP_006776942.1 204496 D 1133852 CDS YP_006776943.1 407479794 13698876 206119..206460 1 NC_018658.1 COG4682 Predicted membrane protein; hypothetical protein 206460 13698876 O3K_01045 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776943.1 206119 D 1133852 CDS YP_006776944.1 407479795 13698877 206506..206943 1 NC_018658.1 COG4682 Predicted membrane protein; hypothetical protein 206943 13698877 O3K_01050 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776944.1 206506 D 1133852 CDS YP_006776945.1 407479796 13698878 complement(206985..207980) 1 NC_018658.1 COG3274 Uncharacterized protein conserved in bacteria; hypothetical protein 207980 13698878 O3K_01055 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776945.1 206985 R 1133852 CDS YP_006776946.1 407479797 13698879 208155..208454 1 NC_018658.1 outer membrane lipoprotein 208454 13698879 O3K_01060 Escherichia coli O104:H4 str. 2011C-3493 outer membrane lipoprotein YP_006776946.1 208155 D 1133852 CDS YP_006776947.1 407479798 13698880 208549..209460 1 NC_018658.1 COG0752 Glycyl-tRNA synthetase, alpha subunit; glycyl-tRNA synthetase subunit alpha 209460 glyQ 13698880 glyQ Escherichia coli O104:H4 str. 2011C-3493 glycyl-tRNA synthetase subunit alpha YP_006776947.1 208549 D 1133852 CDS YP_006776948.1 407479799 13698881 209470..211539 1 NC_018658.1 COG0751 Glycyl-tRNA synthetase, beta subunit; glycyl-tRNA synthetase subunit beta 211539 glyS 13698881 glyS Escherichia coli O104:H4 str. 2011C-3493 glycyl-tRNA synthetase subunit beta YP_006776948.1 209470 D 1133852 CDS YP_006776949.1 407479800 13698882 211805..212017 1 NC_018658.1 small toxic polypeptide 212017 13698882 O3K_01075 Escherichia coli O104:H4 str. 2011C-3493 small toxic polypeptide YP_006776949.1 211805 D 1133852 CDS YP_006776950.1 407479801 13698883 complement(212205..212417) 1 NC_018658.1 COG1278 Cold shock proteins; RNA chaperone/anti-terminator 212417 13698883 O3K_01080 Escherichia coli O104:H4 str. 2011C-3493 RNA chaperone/anti-terminator YP_006776950.1 212205 R 1133852 CDS YP_006776951.1 407479802 13698884 complement(212698..212988) 1 NC_018658.1 COG2944 Predicted transcriptional regulator; transcriptional regulator 212988 13698884 O3K_01085 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator YP_006776951.1 212698 R 1133852 CDS YP_006776952.1 407479803 13698885 213422..214132 1 NC_018658.1 hypothetical protein 214132 13698885 O3K_01090 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776952.1 213422 D 1133852 CDS YP_006776953.1 407479804 13698886 complement(214182..215156) 1 NC_018658.1 COG1052 Lactate dehydrogenase and related dehydrogenases; bifunctional glyoxylate/hydroxypyruvate reductase B 215156 13698886 O3K_01095 Escherichia coli O104:H4 str. 2011C-3493 bifunctional glyoxylate/hydroxypyruvate reductase B YP_006776953.1 214182 R 1133852 CDS YP_006776954.1 407479805 13698887 complement(215260..215919) 1 NC_018658.1 COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins; putative outer membrane lipoprotein 215919 13698887 O3K_01100 Escherichia coli O104:H4 str. 2011C-3493 putative outer membrane lipoprotein YP_006776954.1 215260 R 1133852 CDS YP_006776955.1 407479806 13698888 216072..218405 1 NC_018658.1 COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; biotin sulfoxide reductase 218405 13698888 O3K_01105 Escherichia coli O104:H4 str. 2011C-3493 biotin sulfoxide reductase YP_006776955.1 216072 D 1133852 CDS YP_006776956.1 407479807 13698889 complement(218374..218814) 1 NC_018658.1 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; acetyltransferase 218814 13698889 O3K_01110 Escherichia coli O104:H4 str. 2011C-3493 acetyltransferase YP_006776956.1 218374 R 1133852 CDS YP_006776957.1 407479808 13698890 complement(218811..219374) 1 NC_018658.1 COG2818 3-methyladenine DNA glycosylase; 3-methyladenine DNA glycosylase 219374 13698890 O3K_01115 Escherichia coli O104:H4 str. 2011C-3493 3-methyladenine DNA glycosylase YP_006776957.1 218811 R 1133852 CDS YP_006776958.1 407479809 13698891 219532..220230 1 NC_018658.1 hypothetical protein 220230 13698891 O3K_01120 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776958.1 219532 D 1133852 CDS YP_006776959.1 407479810 13698892 220459..221661 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; transporter 221661 13698892 O3K_01125 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006776959.1 220459 D 1133852 CDS YP_006776960.1 407479811 13698893 221985..222509 1 NC_018658.1 COG3539 P pilus assembly protein, pilin FimA; long polar fimbrial protein LpfA 222509 13698893 O3K_01130 Escherichia coli O104:H4 str. 2011C-3493 long polar fimbrial protein LpfA YP_006776960.1 221985 D 1133852 CDS YP_006776961.1 407479812 13698894 222593..223279 1 NC_018658.1 COG3121 P pilus assembly protein, chaperone PapD; long polar fimbrial chaperone LpfB 223279 13698894 O3K_01135 Escherichia coli O104:H4 str. 2011C-3493 long polar fimbrial chaperone LpfB YP_006776961.1 222593 D 1133852 CDS YP_006776962.1 407479813 13698895 223303..225834 1 NC_018658.1 COG3188 P pilus assembly protein, porin PapC; long polar fimbrial outer membrane usher protein LpfC 225834 13698895 O3K_01140 Escherichia coli O104:H4 str. 2011C-3493 long polar fimbrial outer membrane usher protein LpfC YP_006776962.1 223303 D 1133852 CDS YP_006776963.1 407479814 13698896 225845..226900 1 NC_018658.1 long polar fimbrial protein LpfD 226900 13698896 O3K_01145 Escherichia coli O104:H4 str. 2011C-3493 long polar fimbrial protein LpfD YP_006776963.1 225845 D 1133852 CDS YP_006776964.1 407479815 13698897 226906..227430 1 NC_018658.1 COG3539 P pilus assembly protein, pilin FimA; long polar fimbrial protein LpfE 227430 13698897 O3K_01150 Escherichia coli O104:H4 str. 2011C-3493 long polar fimbrial protein LpfE YP_006776964.1 226906 D 1133852 CDS YP_006776965.1 407479816 13698898 227683..229374 1 NC_018658.1 COG2194 Predicted membrane-associated, metal-dependent hydrolase; phosphoethanolamine transferase 229374 13698898 O3K_01155 Escherichia coli O104:H4 str. 2011C-3493 phosphoethanolamine transferase YP_006776965.1 227683 D 1133852 CDS YP_006776966.1 407479817 13698900 230286..231893 1 NC_018658.1 COG0747 ABC-type dipeptide transport system, periplasmic component; dipeptide transport protein 231893 13698900 O3K_01160 Escherichia coli O104:H4 str. 2011C-3493 dipeptide transport protein YP_006776966.1 230286 D 1133852 CDS YP_006776967.1 407479818 13698901 232044..233063 1 NC_018658.1 COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; dipeptide transporter permease DppB 233063 13698901 O3K_01165 Escherichia coli O104:H4 str. 2011C-3493 dipeptide transporter permease DppB YP_006776967.1 232044 D 1133852 CDS YP_006776968.1 407479819 13698902 233073..233975 1 NC_018658.1 COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; dipeptide transporter 233975 13698902 O3K_01170 Escherichia coli O104:H4 str. 2011C-3493 dipeptide transporter YP_006776968.1 233073 D 1133852 CDS YP_006776969.1 407479820 13698903 233986..234969 1 NC_018658.1 COG0444 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component; dipeptide transporter ATP-binding subunit 234969 dppD 13698903 dppD Escherichia coli O104:H4 str. 2011C-3493 dipeptide transporter ATP-binding subunit YP_006776969.1 233986 D 1133852 CDS YP_006776970.1 407479821 13698904 234966..235970 1 NC_018658.1 COG4608 ABC-type oligopeptide transport system, ATPase component; dipeptide transporter ATP-binding subunit 235970 dppF 13698904 dppF Escherichia coli O104:H4 str. 2011C-3493 dipeptide transporter ATP-binding subunit YP_006776970.1 234966 D 1133852 CDS YP_006776971.1 407479822 13698905 complement(236000..237271) 1 NC_018658.1 COG0814 Amino acid permeases; transporter 237271 13698905 O3K_01185 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006776971.1 236000 R 1133852 CDS YP_006776972.1 407479823 13698906 238229..238336 1 NC_018658.1 toxic polypeptide, small 238336 13698906 O3K_01190 Escherichia coli O104:H4 str. 2011C-3493 toxic polypeptide, small YP_006776972.1 238229 D 1133852 CDS YP_006776973.1 407479824 13698907 238712..238819 1 NC_018658.1 toxic polypeptide, small 238819 13698907 O3K_01195 Escherichia coli O104:H4 str. 2011C-3493 toxic polypeptide, small YP_006776973.1 238712 D 1133852 CDS YP_006776974.1 407479825 13698908 complement(238906..240585) 1 NC_018658.1 hypothetical protein 240585 13698908 O3K_01200 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776974.1 238906 R 1133852 CDS YP_006776975.1 407479826 13698909 complement(240582..240773) 1 NC_018658.1 hypothetical protein 240773 13698909 O3K_01205 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776975.1 240582 R 1133852 CDS YP_006776976.1 407479827 13698910 242615..242803 1 NC_018658.1 hypothetical protein 242803 13698910 O3K_01220 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006776976.1 242615 D 1133852 CDS YP_006776977.1 407479828 13698911 242815..243567 1 NC_018658.1 COG1192 ATPases involved in chromosome partitioning; cell division protein 243567 13698911 O3K_01225 Escherichia coli O104:H4 str. 2011C-3493 cell division protein YP_006776977.1 242815 D 1133852 CDS YP_006776978.1 407479829 13698912 243564..246182 1 NC_018658.1 COG1215 Glycosyltransferases, probably involved in cell wall biogenesis; cellulose synthase catalytic subunit 246182 bcsA 13698912 bcsA Escherichia coli O104:H4 str. 2011C-3493 cellulose synthase catalytic subunit YP_006776978.1 243564 D 1133852 CDS YP_006776979.1 407479830 13698913 246193..248532 1 NC_018658.1 cellulose synthase regulator protein 248532 13698913 O3K_01235 Escherichia coli O104:H4 str. 2011C-3493 cellulose synthase regulator protein YP_006776979.1 246193 D 1133852 CDS YP_006776980.1 407479831 13698914 248539..249645 1 NC_018658.1 COG3405 Endoglucanase Y; endo-1,4-D-glucanase 249645 13698914 O3K_01240 Escherichia coli O104:H4 str. 2011C-3493 endo-1,4-D-glucanase YP_006776980.1 248539 D 1133852 CDS YP_006776981.1 407479832 13698915 249627..253100 1 NC_018658.1 COG0457 FOG: TPR repeat; cellulose synthase subunit BcsC 253100 13698915 O3K_01245 Escherichia coli O104:H4 str. 2011C-3493 cellulose synthase subunit BcsC YP_006776981.1 249627 D 1133852 CDS YP_006776982.1 407479833 13698916 253215..255170 1 NC_018658.1 COG2199 FOG: GGDEF domain; putative diguanylate cyclase 255170 13698916 O3K_01250 Escherichia coli O104:H4 str. 2011C-3493 putative diguanylate cyclase YP_006776982.1 253215 D 1133852 CDS YP_006776983.1 407479834 13698917 255353..256639 1 NC_018658.1 COG1301 Na+/H+-dicarboxylate symporters; C4-dicarboxylate transporter DctA 256639 13698917 O3K_01255 Escherichia coli O104:H4 str. 2011C-3493 C4-dicarboxylate transporter DctA YP_006776983.1 255353 D 1133852 CDS YP_006776984.1 407479835 13698918 256860..258356 1 NC_018658.1 COG0612 Predicted Zn-dependent peptidases; putative zinc-dependent peptidase 258356 13698918 O3K_01260 Escherichia coli O104:H4 str. 2011C-3493 putative zinc-dependent peptidase YP_006776984.1 256860 D 1133852 CDS YP_006776985.1 407479836 13698919 complement(258452..259381) 1 NC_018658.1 COG0524 Sugar kinases, ribokinase family; ketodeoxygluconokinase 259381 13698919 O3K_01265 Escherichia coli O104:H4 str. 2011C-3493 ketodeoxygluconokinase YP_006776985.1 258452 R 1133852 CDS YP_006776986.1 407479837 13698920 259613..260380 1 NC_018658.1 COG2200 FOG: EAL domain; cyclic-di-GMP phosphodiesterase 260380 13698920 O3K_01270 Escherichia coli O104:H4 str. 2011C-3493 cyclic-di-GMP phosphodiesterase YP_006776986.1 259613 D 1133852 CDS YP_006776987.1 407479838 13698921 260450..262510 1 NC_018658.1 COG2982 Uncharacterized protein involved in outer membrane biogenesis; outer membrane biogenesis protein 262510 13698921 O3K_01275 Escherichia coli O104:H4 str. 2011C-3493 outer membrane biogenesis protein YP_006776987.1 260450 D 1133852 CDS YP_006776988.1 407479839 13698922 complement(262744..264066) 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; inner membrane metabolite transport protein yhjE 264066 13698922 O3K_01280 Escherichia coli O104:H4 str. 2011C-3493 inner membrane metabolite transport protein yhjE YP_006776988.1 262744 R 1133852 CDS YP_006776989.1 407479840 13698923 complement(264477..265490) 1 NC_018658.1 COG1295 Predicted membrane protein; ribonuclease 265490 13698923 O3K_01285 Escherichia coli O104:H4 str. 2011C-3493 ribonuclease YP_006776989.1 264477 R 1133852 CDS YP_006776990.1 407479841 13698924 complement(265539..266510) 1 NC_018658.1 COG0583 Transcriptional regulator; putative DNA-binding transcriptional regulator 266510 13698924 O3K_01290 Escherichia coli O104:H4 str. 2011C-3493 putative DNA-binding transcriptional regulator YP_006776990.1 265539 R 1133852 CDS YP_006776991.1 407479842 13698925 266958..267560 1 NC_018658.1 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; HTH-type transcriptional regulator yhjB 267560 13698925 O3K_01295 Escherichia coli O104:H4 str. 2011C-3493 HTH-type transcriptional regulator yhjB YP_006776991.1 266958 D 1133852 CDS YP_006776992.1 407479843 13698926 complement(267611..269260) 1 NC_018658.1 COG1626 Neutral trehalase; trehalase 269260 treF 13698926 treF Escherichia coli O104:H4 str. 2011C-3493 trehalase YP_006776992.1 267611 R 1133852 CDS YP_006776993.1 407479844 13698927 269665..271062 1 NC_018658.1 COG1858 Cytochrome c peroxidase; cytochrome C peroxidase 271062 13698927 O3K_01305 Escherichia coli O104:H4 str. 2011C-3493 cytochrome C peroxidase YP_006776993.1 269665 D 1133852 CDS YP_006776994.1 407479845 13698928 271273..272097 1 NC_018658.1 COG0076 Glutamate decarboxylase and related PLP-dependent proteins; glutamate decarboxylase 272097 13698928 O3K_01310 Escherichia coli O104:H4 str. 2011C-3493 glutamate decarboxylase YP_006776994.1 271273 D 1133852 CDS YP_006776995.1 407479846 13698929 272069..272671 1 NC_018658.1 COG0076 Glutamate decarboxylase and related PLP-dependent proteins; glutamate decarboxylase 272671 13698929 O3K_01315 Escherichia coli O104:H4 str. 2011C-3493 glutamate decarboxylase YP_006776995.1 272069 D 1133852 CDS YP_006776996.1 407479847 13698930 273041..273865 1 NC_018658.1 COG2207 AraC-type DNA-binding domain-containing proteins; DNA-binding transcriptional regulator GadX 273865 13698930 O3K_01320 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator GadX YP_006776996.1 273041 D 1133852 CDS YP_006776997.1 407479848 13698931 274233..274961 1 NC_018658.1 COG2207 AraC-type DNA-binding domain-containing proteins; DNA-binding transcriptional activator GadW 274961 13698931 O3K_01325 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional activator GadW YP_006776997.1 274233 D 1133852 CDS YP_006776998.1 407479849 13698932 complement(275324..278437) 1 NC_018658.1 COG0841 Cation/multidrug efflux pump; multidrug transporter MdtF, RpoS-dependent 278437 13698932 O3K_01330 Escherichia coli O104:H4 str. 2011C-3493 multidrug transporter MdtF, RpoS-dependent YP_006776998.1 275324 R 1133852 CDS YP_006776999.1 407479850 13698933 complement(278462..279619) 1 NC_018658.1 COG0845 Membrane-fusion protein; multidrug efflux system protein MdtE 279619 13698933 O3K_01335 Escherichia coli O104:H4 str. 2011C-3493 multidrug efflux system protein MdtE YP_006776999.1 278462 R 1133852 CDS YP_006777000.1 407479851 13698934 279525..279641 1 NC_018658.1 hypothetical protein 279641 13698934 O3K_01340 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777000.1 279525 D 1133852 CDS YP_006777001.1 407479852 13698935 279679..279957 1 NC_018658.1 hypothetical protein 279957 13698935 O3K_01345 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777001.1 279679 D 1133852 CDS YP_006777002.1 407479853 13698936 complement(279958..280485) 1 NC_018658.1 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; DNA-binding transcriptional activator 280485 13698936 O3K_01350 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional activator YP_006777002.1 279958 R 1133852 CDS YP_006777003.1 407479854 13698937 complement(281284..281856) 1 NC_018658.1 COG3247 Uncharacterized conserved protein; acid-resistance membrane protein 281856 13698937 O3K_01355 Escherichia coli O104:H4 str. 2011C-3493 acid-resistance membrane protein YP_006777003.1 281284 R 1133852 CDS YP_006777004.1 407479855 13698938 282111..282443 1 NC_018658.1 acid-resistance protein 282443 13698938 O3K_01360 Escherichia coli O104:H4 str. 2011C-3493 acid-resistance protein YP_006777004.1 282111 D 1133852 CDS YP_006777005.1 407479856 13698939 282547..282885 1 NC_018658.1 acid-resistance protein 282885 hdeB 13698939 hdeB Escherichia coli O104:H4 str. 2011C-3493 acid-resistance protein YP_006777005.1 282547 D 1133852 CDS YP_006777006.1 407479857 13698940 282949..283596 1 NC_018658.1 COG1285 Uncharacterized membrane protein; putative Mg(2+) transport ATPase 283596 13698940 O3K_01370 Escherichia coli O104:H4 str. 2011C-3493 putative Mg(2+) transport ATPase YP_006777006.1 282949 D 1133852 CDS YP_006777007.1 407479858 13698941 complement(283638..284168) 1 NC_018658.1 COG0055 F0F1-type ATP synthase, beta subunit; DNA-binding transcriptional regulator 284168 13698941 O3K_01375 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator YP_006777007.1 283638 R 1133852 CDS YP_006777008.1 407479859 13698942 complement(284324..284890) 1 NC_018658.1 COG3065 Starvation-inducible outer membrane lipoprotein; outer membrane lipoprotein 284890 13698942 O3K_01380 Escherichia coli O104:H4 str. 2011C-3493 outer membrane lipoprotein YP_006777008.1 284324 R 1133852 CDS YP_006777009.1 407479860 13698943 complement(285214..286359) 1 NC_018658.1 COG1518 Uncharacterized protein predicted to be involved in DNA repair; hypothetical protein 286359 13698943 O3K_01385 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777009.1 285214 R 1133852 CDS YP_006777010.1 407479861 13698944 complement(286939..287952) 1 NC_018658.1 COG0701 Predicted permeases; hypothetical protein 287952 13698944 O3K_01390 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777010.1 286939 R 1133852 CDS YP_006777011.1 407479862 13698945 288059..288355 1 NC_018658.1 COG0640 Predicted transcriptional regulators; hypothetical protein 288355 13698945 O3K_01395 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777011.1 288059 D 1133852 CDS YP_006777012.1 407479863 13698946 complement(288489..288914) 1 NC_018658.1 COG1393 Arsenate reductase and related proteins, glutaredoxin family; arsenate reductase 288914 13698946 O3K_01400 Escherichia coli O104:H4 str. 2011C-3493 arsenate reductase YP_006777012.1 288489 R 1133852 CDS YP_006777013.1 407479864 13698947 complement(288927..290216) 1 NC_018658.1 COG1055 Na+/H+ antiporter NhaD and related arsenite permeases; arsenical pump membrane protein 290216 13698947 O3K_01405 Escherichia coli O104:H4 str. 2011C-3493 arsenical pump membrane protein YP_006777013.1 288927 R 1133852 CDS YP_006777014.1 407479865 13698948 complement(290270..290623) 1 NC_018658.1 COG0640 Predicted transcriptional regulators; DNA-binding transcriptional repressor ArsR 290623 13698948 O3K_01410 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional repressor ArsR YP_006777014.1 290270 R 1133852 CDS YP_006777015.1 407479866 13698949 291297..291446 1 NC_018658.1 hypothetical protein 291446 13698949 O3K_01415 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777015.1 291297 D 1133852 CDS YP_006777016.1 407479867 13698950 complement(291500..292852) 1 NC_018658.1 COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes; glutathione reductase 292852 13698950 O3K_01420 Escherichia coli O104:H4 str. 2011C-3493 glutathione reductase YP_006777016.1 291500 R 1133852 CDS YP_006777017.1 407479868 13698951 complement(292924..293766) 1 NC_018658.1 COG2961 Protein involved in catabolism of external DNA; putative DNA processing protein 293766 13698951 O3K_01425 Escherichia coli O104:H4 str. 2011C-3493 putative DNA processing protein YP_006777017.1 292924 R 1133852 CDS YP_006777018.1 407479869 13698952 293969..296011 1 NC_018658.1 COG0339 Zn-dependent oligopeptidases; oligopeptidase A 296011 13698952 O3K_01430 Escherichia coli O104:H4 str. 2011C-3493 oligopeptidase A YP_006777018.1 293969 D 1133852 CDS YP_006777019.1 407479870 13698953 296019..296771 1 NC_018658.1 COG0500 SAM-dependent methyltransferases; methyltransferase 296771 13698953 O3K_01435 Escherichia coli O104:H4 str. 2011C-3493 methyltransferase YP_006777019.1 296019 D 1133852 CDS YP_006777020.1 407479871 13698954 complement(296820..298289) 1 NC_018658.1 COG3104 Dipeptide/tripeptide permease; dipeptide/tripeptide permease B 298289 13698954 O3K_01440 Escherichia coli O104:H4 str. 2011C-3493 dipeptide/tripeptide permease B YP_006777020.1 296820 R 1133852 CDS YP_006777021.1 407479872 13698955 complement(298607..299041) 1 NC_018658.1 COG0589 Universal stress protein UspA and related nucleotide-binding proteins; universal stress global response regulator UspA 299041 13698955 O3K_01445 Escherichia coli O104:H4 str. 2011C-3493 universal stress global response regulator UspA YP_006777021.1 298607 R 1133852 CDS YP_006777022.1 407479873 13698956 299432..299767 1 NC_018658.1 universal stress protein UspB 299767 13698956 O3K_01450 Escherichia coli O104:H4 str. 2011C-3493 universal stress protein UspB YP_006777022.1 299432 D 1133852 CDS YP_006777023.1 407479874 13698957 complement(299838..301337) 1 NC_018658.1 COG0306 Phosphate/sulphate permeases; Low-affinity inorganic phosphate transporter 1 301337 13698957 O3K_01455 Escherichia coli O104:H4 str. 2011C-3493 Low-affinity inorganic phosphate transporter 1 YP_006777023.1 299838 R 1133852 CDS YP_006777024.1 407479875 13698958 301569..302771 1 NC_018658.1 COG2081 Predicted flavoproteins; pyridine nucleotide-disulfide oxidoreductase 302771 13698958 O3K_01460 Escherichia coli O104:H4 str. 2011C-3493 pyridine nucleotide-disulfide oxidoreductase YP_006777024.1 301569 D 1133852 CDS YP_006777025.1 407479876 13698959 302914..303756 1 NC_018658.1 Tn7-like transposase TnsA 303756 13698959 O3K_01465 Escherichia coli O104:H4 str. 2011C-3493 Tn7-like transposase TnsA YP_006777025.1 302914 D 1133852 CDS YP_006777026.1 407479877 13698960 303743..305866 1 NC_018658.1 COG2801 Transposase and inactivated derivatives; Tn7-like transposition protein TnsB 305866 13698960 O3K_01470 Escherichia coli O104:H4 str. 2011C-3493 Tn7-like transposition protein TnsB YP_006777026.1 303743 D 1133852 CDS YP_006777027.1 407479878 13698961 305866..307314 1 NC_018658.1 COG1132 ABC-type multidrug transport system, ATPase and permease components; Tn7-like transposition protein TnsC 307314 13698961 O3K_01475 Escherichia coli O104:H4 str. 2011C-3493 Tn7-like transposition protein TnsC YP_006777027.1 305866 D 1133852 CDS YP_006777028.1 407479879 13698962 307346..308911 1 NC_018658.1 TnsD 308911 13698962 O3K_01480 Escherichia coli O104:H4 str. 2011C-3493 TnsD YP_006777028.1 307346 D 1133852 CDS YP_006777029.1 407479880 13698963 308923..309849 1 NC_018658.1 hypothetical protein 309849 13698963 O3K_01485 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777029.1 308923 D 1133852 CDS YP_006777030.1 407479881 13698964 310202..310501 1 NC_018658.1 COG1396 Predicted transcriptional regulators; transcriptional regulator 310501 13698964 O3K_01490 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator YP_006777030.1 310202 D 1133852 CDS YP_006777031.1 407479882 13698965 311065..312891 1 NC_018658.1 COG3593 Predicted ATP-dependent endonuclease of the OLD family; hypothetical protein 312891 13698965 O3K_01495 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777031.1 311065 D 1133852 CDS YP_006777032.1 407479883 13698966 complement(313060..313410) 1 NC_018658.1 COG3544 Uncharacterized protein conserved in bacteria; hypothetical protein 313410 13698966 O3K_01500 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777032.1 313060 R 1133852 CDS YP_006777033.1 407479884 13698967 complement(313558..314106) 1 NC_018658.1 silver-binding protein SilE 314106 13698967 O3K_01505 Escherichia coli O104:H4 str. 2011C-3493 silver-binding protein SilE YP_006777033.1 313558 R 1133852 CDS YP_006777034.1 407479885 13698968 complement(314234..315715) 1 NC_018658.1 COG0642 Signal transduction histidine kinase; sensor kinase CusS 315715 13698968 O3K_01510 Escherichia coli O104:H4 str. 2011C-3493 sensor kinase CusS YP_006777034.1 314234 R 1133852 CDS YP_006777035.1 407479886 13698969 complement(315708..316388) 1 NC_018658.1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; DNA-binding transcriptional activator CusR 316388 13698969 O3K_01515 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional activator CusR YP_006777035.1 315708 R 1133852 CDS YP_006777036.1 407479887 13698970 316578..317963 1 NC_018658.1 COG1538 Outer membrane protein; copper/silver efflux system outer membrane protein CusC 317963 13698970 O3K_01520 Escherichia coli O104:H4 str. 2011C-3493 copper/silver efflux system outer membrane protein CusC YP_006777036.1 316578 D 1133852 CDS YP_006777037.1 407479888 13698971 317991..318344 1 NC_018658.1 COG5569 Uncharacterized conserved protein; copper-binding protein 318344 13698971 O3K_01525 Escherichia coli O104:H4 str. 2011C-3493 copper-binding protein YP_006777037.1 317991 D 1133852 CDS YP_006777038.1 407479889 13698972 318458..319750 1 NC_018658.1 COG0845 Membrane-fusion protein; copper/silver efflux system membrane fusion protein CusB 319750 13698972 O3K_01530 Escherichia coli O104:H4 str. 2011C-3493 copper/silver efflux system membrane fusion protein CusB YP_006777038.1 318458 D 1133852 CDS YP_006777039.1 407479890 13698973 319761..322907 1 NC_018658.1 COG3696 Putative silver efflux pump; Cu(I)/Ag(I) efflux system membrane protein CusA 322907 13698973 O3K_01535 Escherichia coli O104:H4 str. 2011C-3493 Cu(I)/Ag(I) efflux system membrane protein CusA YP_006777039.1 319761 D 1133852 CDS YP_006777040.1 407479891 13698974 322994..323434 1 NC_018658.1 COG3019 Predicted metal-binding protein; hypothetical protein 323434 13698974 O3K_01540 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777040.1 322994 D 1133852 CDS YP_006777041.1 407479892 13698975 323561..326008 1 NC_018658.1 COG2217 Cation transport ATPase; cation-transporting P-type ATPase 326008 13698975 O3K_01545 Escherichia coli O104:H4 str. 2011C-3493 cation-transporting P-type ATPase YP_006777041.1 323561 D 1133852 CDS YP_006777042.1 407479893 13698976 326049..326246 1 NC_018658.1 hypothetical protein 326246 13698976 O3K_01550 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777042.1 326049 D 1133852 CDS YP_006777043.1 407479894 13698977 complement(326280..327017) 1 NC_018658.1 COG0739 Membrane proteins related to metalloendopeptidases; peptidase 327017 13698977 O3K_01555 Escherichia coli O104:H4 str. 2011C-3493 peptidase YP_006777043.1 326280 R 1133852 CDS YP_006777044.1 407479895 13698978 327110..327196 1 NC_018658.1 hypothetical protein 327196 13698978 O3K_01560 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777044.1 327110 D 1133852 CDS YP_006777045.1 407479896 13698979 complement(327306..327755) 1 NC_018658.1 copper resistant protein PcoE 327755 13698979 O3K_01565 Escherichia coli O104:H4 str. 2011C-3493 copper resistant protein PcoE YP_006777045.1 327306 R 1133852 CDS YP_006777046.1 407479897 13698980 327990..329807 1 NC_018658.1 COG2132 Putative multicopper oxidases; copper resistant protein PcoA 329807 13698980 O3K_01570 Escherichia coli O104:H4 str. 2011C-3493 copper resistant protein PcoA YP_006777046.1 327990 D 1133852 CDS YP_006777047.1 407479898 13698981 329804..330703 1 NC_018658.1 COG3667 Uncharacterized protein involved in copper resistance; copper resistance protein B 330703 13698981 O3K_01575 Escherichia coli O104:H4 str. 2011C-3493 copper resistance protein B YP_006777047.1 329804 D 1133852 CDS YP_006777048.1 407479899 13698982 330743..331123 1 NC_018658.1 COG2372 Uncharacterized protein, homolog of Cu resistance protein CopC; copper resistant protein PcoC 331123 13698982 O3K_01580 Escherichia coli O104:H4 str. 2011C-3493 copper resistant protein PcoC YP_006777048.1 330743 D 1133852 CDS YP_006777049.1 407479900 13698983 331128..332057 1 NC_018658.1 COG1276 Putative copper export protein; copper resistance protein D 332057 13698983 O3K_01585 Escherichia coli O104:H4 str. 2011C-3493 copper resistance protein D YP_006777049.1 331128 D 1133852 CDS YP_006777050.1 407479901 13698984 332112..332792 1 NC_018658.1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; transcriptional regulator PcoR 332792 13698984 O3K_01590 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator PcoR YP_006777050.1 332112 D 1133852 CDS YP_006777051.1 407479902 13698985 332789..334189 1 NC_018658.1 COG0642 Signal transduction histidine kinase; sensor protein pcoS 334189 13698985 O3K_01595 Escherichia coli O104:H4 str. 2011C-3493 sensor protein pcoS YP_006777051.1 332789 D 1133852 CDS YP_006777052.1 407479903 13698986 334407..334841 1 NC_018658.1 copper-binding protein 334841 13698986 O3K_01600 Escherichia coli O104:H4 str. 2011C-3493 copper-binding protein YP_006777052.1 334407 D 1133852 CDS YP_006777053.1 407479904 13698987 complement(335501..336553) 1 NC_018658.1 hypothetical protein 336553 13698987 O3K_01605 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777053.1 335501 R 1133852 CDS YP_006777054.1 407479905 13698988 336938..338023 1 NC_018658.1 hypothetical protein 338023 13698988 O3K_01610 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777054.1 336938 D 1133852 CDS YP_006777055.1 407479906 13698989 338191..338562 1 NC_018658.1 hypothetical protein 338562 13698989 O3K_01615 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777055.1 338191 D 1133852 CDS YP_006777056.1 407479907 13698990 340811..341878 1 NC_018658.1 COG0845 Membrane-fusion protein; HlyD family secretion protein 341878 13698990 O3K_01630 Escherichia coli O104:H4 str. 2011C-3493 HlyD family secretion protein YP_006777056.1 340811 D 1133852 CDS YP_006777057.1 407479908 13698991 341875..344610 1 NC_018658.1 COG1131 ABC-type multidrug transport system, ATPase component; ribosome-associated ATPase/membrane protein 344610 13698991 O3K_01635 Escherichia coli O104:H4 str. 2011C-3493 ribosome-associated ATPase/membrane protein YP_006777057.1 341875 D 1133852 CDS YP_006777058.1 407479909 13698992 344610..345734 1 NC_018658.1 COG0842 ABC-type multidrug transport system, permease component; transporter subunit 345734 13698992 O3K_01640 Escherichia coli O104:H4 str. 2011C-3493 transporter subunit YP_006777058.1 344610 D 1133852 CDS YP_006777059.1 407479910 13698993 346065..346424 1 NC_018658.1 COG4226 Uncharacterized protein encoded in hypervariable junctions of pilus gene clusters; HicB family protein 346424 13698993 O3K_01645 Escherichia coli O104:H4 str. 2011C-3493 HicB family protein YP_006777059.1 346065 D 1133852 CDS YP_006777060.1 407479911 13698994 complement(346544..346945) 1 NC_018658.1 COG0864 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain; nickel responsive regulator 346945 13698994 O3K_01650 Escherichia coli O104:H4 str. 2011C-3493 nickel responsive regulator YP_006777060.1 346544 R 1133852 CDS YP_006777061.1 407479912 13698995 complement(346951..347757) 1 NC_018658.1 COG1124 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component; nickel transporter ATP-binding protein NikE 347757 nikE 13698995 nikE Escherichia coli O104:H4 str. 2011C-3493 nickel transporter ATP-binding protein NikE YP_006777061.1 346951 R 1133852 CDS YP_006777062.1 407479913 13698996 complement(347754..348518) 1 NC_018658.1 COG0444 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component; nickel transporter ATP-binding protein NikD 348518 nikD 13698996 nikD Escherichia coli O104:H4 str. 2011C-3493 nickel transporter ATP-binding protein NikD YP_006777062.1 347754 R 1133852 CDS YP_006777063.1 407479914 13698997 complement(348518..349351) 1 NC_018658.1 COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; nickel transporter permease NikC 349351 nikC 13698997 nikC Escherichia coli O104:H4 str. 2011C-3493 nickel transporter permease NikC YP_006777063.1 348518 R 1133852 CDS YP_006777064.1 407479915 13698998 complement(349348..350292) 1 NC_018658.1 COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; nickel transporter permease NikB 350292 13698998 O3K_01670 Escherichia coli O104:H4 str. 2011C-3493 nickel transporter permease NikB YP_006777064.1 349348 R 1133852 CDS YP_006777065.1 407479916 13698999 complement(350292..351866) 1 NC_018658.1 COG0747 ABC-type dipeptide transport system, periplasmic component; periplasmic binding protein for nickel NikA 351866 13698999 O3K_01675 Escherichia coli O104:H4 str. 2011C-3493 periplasmic binding protein for nickel NikA YP_006777065.1 350292 R 1133852 CDS YP_006777066.1 407479917 13699000 complement(351977..352564) 1 NC_018658.1 COG2091 Phosphopantetheinyl transferase; holo-(acyl carrier protein) synthase 2 352564 13699000 O3K_01680 Escherichia coli O104:H4 str. 2011C-3493 holo-(acyl carrier protein) synthase 2 YP_006777066.1 351977 R 1133852 CDS YP_006777067.1 407479918 13699001 complement(352619..353668) 1 NC_018658.1 COG0628 Predicted permease; inner membrane protein 353668 13699001 O3K_01685 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006777067.1 352619 R 1133852 CDS YP_006777068.1 407479919 13699002 353800..355017 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; major facilitator superfamily transporter 355017 13699002 O3K_01690 Escherichia coli O104:H4 str. 2011C-3493 major facilitator superfamily transporter YP_006777068.1 353800 D 1133852 CDS YP_006777069.1 407479920 13699003 complement(355021..355578) 1 NC_018658.1 hypothetical protein 355578 13699003 O3K_01695 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777069.1 355021 R 1133852 CDS YP_006777070.1 407479921 13699004 complement(355651..356316) 1 NC_018658.1 COG1738 Uncharacterized conserved protein; hypothetical protein 356316 13699004 O3K_01700 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777070.1 355651 R 1133852 CDS YP_006777071.1 407479922 13699005 356537..356782 1 NC_018658.1 COG0425 Predicted redox protein, regulator of disulfide bond formation; sulfur transfer protein SirA 356782 13699005 O3K_01705 Escherichia coli O104:H4 str. 2011C-3493 sulfur transfer protein SirA YP_006777071.1 356537 D 1133852 CDS YP_006777072.1 407479923 13699006 complement(356884..359082) 1 NC_018658.1 COG2217 Cation transport ATPase; zinc/cadmium/mercury/lead-transporting ATPase 359082 zntA 13699006 zntA Escherichia coli O104:H4 str. 2011C-3493 zinc/cadmium/mercury/lead-transporting ATPase YP_006777072.1 356884 R 1133852 CDS YP_006777073.1 407479924 13699007 complement(359156..359782) 1 NC_018658.1 COG3714 Predicted membrane protein; hypothetical protein 359782 13699007 O3K_01715 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777073.1 359156 R 1133852 CDS YP_006777074.1 407479925 13699008 359923..360282 1 NC_018658.1 hypothetical protein 360282 13699008 O3K_01720 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777074.1 359923 D 1133852 CDS YP_006777075.1 407479926 13699009 complement(360285..360554) 1 NC_018658.1 COG3776 Predicted membrane protein; hypothetical protein 360554 13699009 O3K_01725 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777075.1 360285 R 1133852 CDS YP_006777076.1 407479927 13699010 complement(360544..361140) 1 NC_018658.1 COG0742 N6-adenine-specific methylase; 16S rRNA m(2)G966-methyltransferase 361140 rsmD 13699010 rsmD Escherichia coli O104:H4 str. 2011C-3493 16S rRNA m(2)G966-methyltransferase YP_006777076.1 360544 R 1133852 CDS YP_006777077.1 407479928 13699011 361290..362783 1 NC_018658.1 COG0552 Signal recognition particle GTPase; signal recognition particle-docking protein FtsY 362783 13699011 O3K_01735 Escherichia coli O104:H4 str. 2011C-3493 signal recognition particle-docking protein FtsY YP_006777077.1 361290 D 1133852 CDS YP_006777078.1 407479929 13699012 362786..363454 1 NC_018658.1 COG2884 Predicted ATPase involved in cell division; cell division protein FtsE 363454 13699012 O3K_01740 Escherichia coli O104:H4 str. 2011C-3493 cell division protein FtsE YP_006777078.1 362786 D 1133852 CDS YP_006777079.1 407479930 13699013 363447..364505 1 NC_018658.1 COG2177 Cell division protein; cell division ABC transporter subunit FtsX 364505 ftsX 13699013 ftsX Escherichia coli O104:H4 str. 2011C-3493 cell division ABC transporter subunit FtsX YP_006777079.1 363447 D 1133852 CDS YP_006777080.1 407479931 13699014 364750..365604 1 NC_018658.1 COG0568 DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32); RNA polymerase factor sigma-32 365604 13699014 O3K_01750 Escherichia coli O104:H4 str. 2011C-3493 RNA polymerase factor sigma-32 YP_006777080.1 364750 D 1133852 CDS YP_006777081.1 407479932 13699015 365875..366978 1 NC_018658.1 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component; leucine ABC transporter subunit substrate-binding protein LivK 366978 13699015 O3K_01755 Escherichia coli O104:H4 str. 2011C-3493 leucine ABC transporter subunit substrate-binding protein LivK YP_006777081.1 365875 D 1133852 CDS YP_006777082.1 407479933 13699016 complement(367034..367168) 1 NC_018658.1 hypothetical protein 367168 13699016 O3K_01760 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777082.1 367034 R 1133852 CDS YP_006777083.1 407479934 13699017 complement(367177..367560) 1 NC_018658.1 hypothetical protein 367560 13699017 O3K_01765 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777083.1 367177 R 1133852 CDS YP_006777084.1 407479935 13699018 367984..369093 1 NC_018658.1 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component; leucine ABC transporter subunit substrate-binding protein LivK 369093 13699018 O3K_01770 Escherichia coli O104:H4 str. 2011C-3493 leucine ABC transporter subunit substrate-binding protein LivK YP_006777084.1 367984 D 1133852 CDS YP_006777085.1 407479936 13699019 369141..370067 1 NC_018658.1 COG0559 Branched-chain amino acid ABC-type transport system, permease components; branched-chain amino acid transporter permease LivH 370067 13699019 O3K_01775 Escherichia coli O104:H4 str. 2011C-3493 branched-chain amino acid transporter permease LivH YP_006777085.1 369141 D 1133852 CDS YP_006777086.1 407479937 13699020 370064..371341 1 NC_018658.1 COG4177 ABC-type branched-chain amino acid transport system, permease component; leucine/isoleucine/valine transporter permease subunit 371341 livM 13699020 livM Escherichia coli O104:H4 str. 2011C-3493 leucine/isoleucine/valine transporter permease subunit YP_006777086.1 370064 D 1133852 CDS YP_006777087.1 407479938 13699021 371338..372105 1 NC_018658.1 COG0411 ABC-type branched-chain amino acid transport systems, ATPase component; leucine/isoleucine/valine transporter ATP-binding subunit 372105 livG 13699021 livG Escherichia coli O104:H4 str. 2011C-3493 leucine/isoleucine/valine transporter ATP-binding subunit YP_006777087.1 371338 D 1133852 CDS YP_006777088.1 407479939 13699022 372119..372820 1 NC_018658.1 COG0410 ABC-type branched-chain amino acid transport systems, ATPase component; leucine/isoleucine/valine transporter ATP-binding subunit 372820 livF 13699022 livF Escherichia coli O104:H4 str. 2011C-3493 leucine/isoleucine/valine transporter ATP-binding subunit YP_006777088.1 372119 D 1133852 CDS YP_006777089.1 407479940 13699023 372856..372984 1 NC_018658.1 hypothetical protein 372984 13699023 O3K_01795 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777089.1 372856 D 1133852 CDS YP_006777090.1 407479941 13699024 373216..374532 1 NC_018658.1 COG1653 ABC-type sugar transport system, periplasmic component; glycerol-3-phosphate transporter periplasmic binding protein 374532 13699024 O3K_01800 Escherichia coli O104:H4 str. 2011C-3493 glycerol-3-phosphate transporter periplasmic binding protein YP_006777090.1 373216 D 1133852 CDS YP_006777091.1 407479942 13699025 374630..375517 1 NC_018658.1 COG1175 ABC-type sugar transport systems, permease components; glycerol-3-phosphate transporter permease 375517 13699025 O3K_01805 Escherichia coli O104:H4 str. 2011C-3493 glycerol-3-phosphate transporter permease YP_006777091.1 374630 D 1133852 CDS YP_006777092.1 407479943 13699026 375514..376359 1 NC_018658.1 COG0395 ABC-type sugar transport system, permease component; glycerol-3-phosphate transporter membrane protein 376359 13699026 O3K_01810 Escherichia coli O104:H4 str. 2011C-3493 glycerol-3-phosphate transporter membrane protein YP_006777092.1 375514 D 1133852 CDS YP_006777093.1 407479944 13699027 376361..377431 1 NC_018658.1 COG3839 ABC-type sugar transport systems, ATPase components; glycerol-3-phosphate transporter ATP-binding subunit 377431 ugpC 13699027 ugpC Escherichia coli O104:H4 str. 2011C-3493 glycerol-3-phosphate transporter ATP-binding subunit YP_006777093.1 376361 D 1133852 CDS YP_006777094.1 407479945 13699028 377428..378171 1 NC_018658.1 COG0584 Glycerophosphoryl diester phosphodiesterase; glycerophosphodiester phosphodiesterase 378171 ugpQ 13699028 ugpQ Escherichia coli O104:H4 str. 2011C-3493 glycerophosphodiester phosphodiesterase YP_006777094.1 377428 D 1133852 CDS YP_006777095.1 407479946 13699029 complement(378158..378598) 1 NC_018658.1 hypothetical protein 378598 13699029 O3K_01825 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777095.1 378158 R 1133852 CDS YP_006777096.1 407479947 13699030 378718..380460 1 NC_018658.1 COG0405 Gamma-glutamyltransferase; gamma-glutamyltranspeptidase 380460 ggt 13699030 ggt Escherichia coli O104:H4 str. 2011C-3493 gamma-glutamyltranspeptidase YP_006777096.1 378718 D 1133852 CDS YP_006777097.1 407479948 13699031 complement(380498..380782) 1 NC_018658.1 hypothetical protein 380782 13699031 O3K_01835 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777097.1 380498 R 1133852 CDS YP_006777098.1 407479949 13699032 complement(381232..381726) 1 NC_018658.1 hypothetical protein 381726 13699032 O3K_01840 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777098.1 381232 R 1133852 CDS YP_006777099.1 407479950 13699033 complement(381723..382901) 1 NC_018658.1 COG3157 Hemolysin-coregulated protein (uncharacterized); hypothetical protein 382901 13699033 O3K_01845 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777099.1 381723 R 1133852 CDS YP_006777100.1 407479951 13699034 complement(383138..383626) 1 NC_018658.1 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; putative acetyltransferase YhhY 383626 13699034 O3K_01850 Escherichia coli O104:H4 str. 2011C-3493 putative acetyltransferase YhhY YP_006777100.1 383138 R 1133852 CDS YP_006777101.1 407479952 13699035 383958..384995 1 NC_018658.1 COG0673 Predicted dehydrogenases and related proteins; oxidoreductase 384995 13699035 O3K_01855 Escherichia coli O104:H4 str. 2011C-3493 oxidoreductase YP_006777101.1 383958 D 1133852 CDS YP_006777102.1 407479953 13699036 385118..385813 1 NC_018658.1 COG1741 Pirin-related protein; protein yhhW 385813 13699036 O3K_01860 Escherichia coli O104:H4 str. 2011C-3493 protein yhhW YP_006777102.1 385118 D 1133852 CDS YP_006777103.1 407479954 13699037 386037..387032 1 NC_018658.1 COG1609 Transcriptional regulators; gluconate operon transcriptional regulator 387032 13699037 O3K_01865 Escherichia coli O104:H4 str. 2011C-3493 gluconate operon transcriptional regulator YP_006777103.1 386037 D 1133852 CDS YP_006777104.1 407479955 13699038 387171..387698 1 NC_018658.1 COG3265 Gluconate kinase; gluconate kinase 387698 gntK 13699038 gntK Escherichia coli O104:H4 str. 2011C-3493 gluconate kinase YP_006777104.1 387171 D 1133852 CDS YP_006777105.1 407479956 13699039 387702..389042 1 NC_018658.1 COG2610 H+/gluconate symporter and related permeases; low affinity gluconate transporter 389042 13699039 O3K_01875 Escherichia coli O104:H4 str. 2011C-3493 low affinity gluconate transporter YP_006777105.1 387702 D 1133852 CDS YP_006777106.1 407479957 13699040 complement(389099..389692) 1 NC_018658.1 COG2095 Multiple antibiotic transporter; putative antibiotic transporter 389692 13699040 O3K_01880 Escherichia coli O104:H4 str. 2011C-3493 putative antibiotic transporter YP_006777106.1 389099 R 1133852 CDS YP_006777107.1 407479958 13699041 389885..390988 1 NC_018658.1 COG0136 Aspartate-semialdehyde dehydrogenase; aspartate-semialdehyde dehydrogenase 390988 13699041 O3K_01885 Escherichia coli O104:H4 str. 2011C-3493 aspartate-semialdehyde dehydrogenase YP_006777107.1 389885 D 1133852 CDS YP_006777108.1 407479959 13699042 391261..393447 1 NC_018658.1 COG0296 1,4-alpha-glucan branching enzyme; glycogen branching protein 393447 13699042 O3K_01890 Escherichia coli O104:H4 str. 2011C-3493 glycogen branching protein YP_006777108.1 391261 D 1133852 CDS YP_006777109.1 407479960 13699043 393444..395417 1 NC_018658.1 COG1523 Type II secretory pathway, pullulanase PulA and related glycosidases; glycogen debranching protein 395417 13699043 O3K_01895 Escherichia coli O104:H4 str. 2011C-3493 glycogen debranching protein YP_006777109.1 393444 D 1133852 CDS YP_006777110.1 407479961 13699044 395435..396730 1 NC_018658.1 COG0448 ADP-glucose pyrophosphorylase; glucose-1-phosphate adenylyltransferase 396730 glgC 13699044 glgC Escherichia coli O104:H4 str. 2011C-3493 glucose-1-phosphate adenylyltransferase YP_006777110.1 395435 D 1133852 CDS YP_006777111.1 407479962 13699045 396730..398163 1 NC_018658.1 COG0297 Glycogen synthase; glycogen synthase 398163 glgA 13699045 glgA Escherichia coli O104:H4 str. 2011C-3493 glycogen synthase YP_006777111.1 396730 D 1133852 CDS YP_006777112.1 407479963 13699046 398182..400629 1 NC_018658.1 COG0058 Glucan phosphorylase; glycogen phosphorylase 400629 13699046 O3K_01910 Escherichia coli O104:H4 str. 2011C-3493 glycogen phosphorylase YP_006777112.1 398182 D 1133852 CDS YP_006777113.1 407479964 13699047 400745..402262 1 NC_018658.1 COG0226 ABC-type phosphate transport system, periplasmic component; phosphate transport system substrate-binding protein 402262 13699047 O3K_01915 Escherichia coli O104:H4 str. 2011C-3493 phosphate transport system substrate-binding protein YP_006777113.1 400745 D 1133852 CDS YP_006777114.1 407479965 13699048 402278..402988 1 NC_018658.1 hypothetical protein 402988 13699048 O3K_01920 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777114.1 402278 D 1133852 CDS YP_006777115.1 407479966 13699049 402991..403758 1 NC_018658.1 hypothetical protein 403758 13699049 O3K_01925 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777115.1 402991 D 1133852 CDS YP_006777116.1 407479967 13699050 403761..404366 1 NC_018658.1 hypothetical protein 404366 13699050 O3K_01930 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777116.1 403761 D 1133852 CDS YP_006777117.1 407479968 13699051 complement(404418..405923) 1 NC_018658.1 COG0578 Glycerol-3-phosphate dehydrogenase; glycerol-3-phosphate dehydrogenase 405923 glpD 13699051 glpD Escherichia coli O104:H4 str. 2011C-3493 glycerol-3-phosphate dehydrogenase YP_006777117.1 404418 R 1133852 CDS YP_006777118.1 407479969 13699052 406113..406439 1 NC_018658.1 COG0607 Rhodanese-related sulfurtransferase; thiosulfate sulfurtransferase 406439 glpE 13699052 glpE Escherichia coli O104:H4 str. 2011C-3493 thiosulfate sulfurtransferase YP_006777118.1 406113 D 1133852 CDS YP_006777119.1 407479970 13699053 406484..407314 1 NC_018658.1 COG0705 Uncharacterized membrane protein (homolog of Drosophila rhomboid); intramembrane serine protease GlpG 407314 13699053 O3K_01945 Escherichia coli O104:H4 str. 2011C-3493 intramembrane serine protease GlpG YP_006777119.1 406484 D 1133852 CDS YP_006777120.1 407479971 13699054 407331..408089 1 NC_018658.1 COG1349 Transcriptional regulators of sugar metabolism; DNA-binding transcriptional repressor GlpR 408089 13699054 O3K_01950 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional repressor GlpR YP_006777120.1 407331 D 1133852 CDS YP_006777121.1 407479972 13699055 complement(408071..409669) 1 NC_018658.1 COG4650 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain; sigma 54-dependent transcriptional regulator of rtcBA expression 409669 13699055 O3K_01955 Escherichia coli O104:H4 str. 2011C-3493 sigma 54-dependent transcriptional regulator of rtcBA expression YP_006777121.1 408071 R 1133852 CDS YP_006777122.1 407479973 13699056 409858..411084 1 NC_018658.1 COG1690 Uncharacterized conserved protein; hypothetical protein 411084 13699056 O3K_01960 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777122.1 409858 D 1133852 CDS YP_006777123.1 407479974 13699057 411088..412104 1 NC_018658.1 COG0430 RNA 3'-terminal phosphate cyclase; RNA 3'-terminal-phosphate cyclase 412104 13699057 O3K_01965 Escherichia coli O104:H4 str. 2011C-3493 RNA 3'-terminal-phosphate cyclase YP_006777123.1 411088 D 1133852 CDS YP_006777124.1 407479975 13699058 complement(412147..414852) 1 NC_018658.1 COG2909 ATP-dependent transcriptional regulator; transcriptional regulator MalT 414852 13699058 O3K_01970 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator MalT YP_006777124.1 412147 R 1133852 CDS YP_006777125.1 407479976 13699059 415464..417857 1 NC_018658.1 COG0058 Glucan phosphorylase; maltodextrin phosphorylase 417857 13699059 O3K_01975 Escherichia coli O104:H4 str. 2011C-3493 maltodextrin phosphorylase YP_006777125.1 415464 D 1133852 CDS YP_006777126.1 407479977 13699060 417867..419951 1 NC_018658.1 COG1640 4-alpha-glucanotransferase; 4-alpha-glucanotransferase 419951 malQ 13699060 malQ Escherichia coli O104:H4 str. 2011C-3493 4-alpha-glucanotransferase YP_006777126.1 417867 D 1133852 CDS YP_006777127.1 407479978 13699061 complement(419996..421312) 1 NC_018658.1 COG2610 H+/gluconate symporter and related permeases; high-affinity gluconate transporter 421312 13699061 O3K_01985 Escherichia coli O104:H4 str. 2011C-3493 high-affinity gluconate transporter YP_006777127.1 419996 R 1133852 CDS YP_006777128.1 407479979 13699062 complement(421673..422248) 1 NC_018658.1 COG0316 Uncharacterized conserved protein; Fe/S biogenesis protein NfuA 422248 13699062 O3K_01990 Escherichia coli O104:H4 str. 2011C-3493 Fe/S biogenesis protein NfuA YP_006777128.1 421673 R 1133852 CDS YP_006777129.1 407479980 13699063 complement(422307..422990) 1 NC_018658.1 COG1040 Predicted amidophosphoribosyltransferases; DNA utilization protein GntX 422990 13699063 O3K_01995 Escherichia coli O104:H4 str. 2011C-3493 DNA utilization protein GntX YP_006777129.1 422307 R 1133852 CDS YP_006777130.1 407479981 13699064 423028..423798 1 NC_018658.1 COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily); carboxylesterase BioH 423798 13699064 O3K_02000 Escherichia coli O104:H4 str. 2011C-3493 carboxylesterase BioH YP_006777130.1 423028 D 1133852 CDS YP_006777131.1 407479982 13699065 complement(423827..424705) 1 NC_018658.1 transposase 424705 13699065 O3K_02005 Escherichia coli O104:H4 str. 2011C-3493 transposase YP_006777131.1 423827 R 1133852 CDS YP_006777132.1 407479983 13699066 complement(424908..425144) 1 NC_018658.1 ferrous iron transport protein FeoC 425144 13699066 O3K_02010 Escherichia coli O104:H4 str. 2011C-3493 ferrous iron transport protein FeoC YP_006777132.1 424908 R 1133852 CDS YP_006777133.1 407479984 13699067 complement(425144..427465) 1 NC_018658.1 COG0370 Fe2+ transport system protein B; ferrous iron transport protein B 427465 feoB 13699067 feoB Escherichia coli O104:H4 str. 2011C-3493 ferrous iron transport protein B YP_006777133.1 425144 R 1133852 CDS YP_006777134.1 407479985 13699068 complement(427482..427709) 1 NC_018658.1 COG1918 Fe2+ transport system protein A; ferrous iron transport protein A 427709 feoA 13699068 feoA Escherichia coli O104:H4 str. 2011C-3493 ferrous iron transport protein A YP_006777134.1 427482 R 1133852 CDS YP_006777135.1 407479986 13699069 complement(428147..430468) 1 NC_018658.1 COG2183 Transcriptional accessory protein; putative transcriptional accessory protein 430468 13699069 O3K_02025 Escherichia coli O104:H4 str. 2011C-3493 putative transcriptional accessory protein YP_006777135.1 428147 R 1133852 CDS YP_006777136.1 407479987 13699070 complement(430565..431041) 1 NC_018658.1 COG0782 Transcription elongation factor; transcription elongation factor GreB 431041 greB 13699070 greB Escherichia coli O104:H4 str. 2011C-3493 transcription elongation factor GreB YP_006777136.1 430565 R 1133852 CDS YP_006777137.1 407479988 13699071 431269..431988 1 NC_018658.1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; osmolarity response regulator 431988 ompR 13699071 ompR Escherichia coli O104:H4 str. 2011C-3493 osmolarity response regulator YP_006777137.1 431269 D 1133852 CDS YP_006777138.1 407479989 13699072 431985..433337 1 NC_018658.1 COG0642 Signal transduction histidine kinase; osmolarity sensor protein 433337 envZ 13699072 envZ Escherichia coli O104:H4 str. 2011C-3493 osmolarity sensor protein YP_006777138.1 431985 D 1133852 CDS YP_006777139.1 407479990 13699073 complement(433367..433663) 1 NC_018658.1 COG2944 Predicted transcriptional regulator; HTH-type transcriptional regulator yiaG 433663 13699073 O3K_02045 Escherichia coli O104:H4 str. 2011C-3493 HTH-type transcriptional regulator yiaG YP_006777139.1 433367 R 1133852 CDS YP_006777140.1 407479991 13699074 complement(433722..434039) 1 NC_018658.1 COG2026 Cytotoxic translational repressor of toxin-antitoxin stability system; hypothetical protein 434039 13699074 O3K_02050 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777140.1 433722 R 1133852 CDS YP_006777141.1 407479992 13699075 complement(434156..435778) 1 NC_018658.1 COG1866 Phosphoenolpyruvate carboxykinase (ATP); phosphoenolpyruvate carboxykinase 435778 13699075 O3K_02055 Escherichia coli O104:H4 str. 2011C-3493 phosphoenolpyruvate carboxykinase YP_006777141.1 434156 R 1133852 CDS YP_006777142.1 407479993 13699076 436157..437881 1 NC_018658.1 inner membrane protein 437881 13699076 O3K_02060 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006777142.1 436157 D 1133852 CDS YP_006777143.1 407479994 13699077 complement(438016..438894) 1 NC_018658.1 COG1281 Disulfide bond chaperones of the HSP33 family; Hsp33-like chaperonin 438894 hslO 13699077 hslO Escherichia coli O104:H4 str. 2011C-3493 Hsp33-like chaperonin YP_006777143.1 438016 R 1133852 CDS YP_006777144.1 407479995 13699078 complement(438919..439320) 1 NC_018658.1 COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog); ribosome-associated heat shock protein Hsp15 439320 13699078 O3K_02070 Escherichia coli O104:H4 str. 2011C-3493 ribosome-associated heat shock protein Hsp15 YP_006777144.1 438919 R 1133852 CDS YP_006777145.1 407479996 13699079 complement(439331..439999) 1 NC_018658.1 COG1011 Predicted hydrolase (HAD superfamily); GMP/IMP nucleotidase 439999 13699079 O3K_02075 Escherichia coli O104:H4 str. 2011C-3493 GMP/IMP nucleotidase YP_006777145.1 439331 R 1133852 CDS YP_006777146.1 407479997 13699080 complement(440064..442199) 1 NC_018658.1 intracellular growth attenuator protein 442199 13699080 O3K_02080 Escherichia coli O104:H4 str. 2011C-3493 intracellular growth attenuator protein YP_006777146.1 440064 R 1133852 CDS YP_006777147.1 407479998 13699081 442519..443079 1 NC_018658.1 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; adenosine nucleotide hydrolase NudE 443079 nudE 13699081 nudE Escherichia coli O104:H4 str. 2011C-3493 adenosine nucleotide hydrolase NudE YP_006777147.1 442519 D 1133852 CDS YP_006777148.1 407479999 13699082 complement(443247..445799) 1 NC_018658.1 COG5009 Membrane carboxypeptidase/penicillin-binding protein; penicillin-binding protein 1a 445799 mrcA 13699082 mrcA Escherichia coli O104:H4 str. 2011C-3493 penicillin-binding protein 1a YP_006777148.1 443247 R 1133852 CDS YP_006777149.1 407480000 13699083 445919..446698 1 NC_018658.1 putative pilus assembly protein 446698 13699083 O3K_02095 Escherichia coli O104:H4 str. 2011C-3493 putative pilus assembly protein YP_006777149.1 445919 D 1133852 CDS YP_006777150.1 407480001 13699084 446698..447237 1 NC_018658.1 putative fimbrial assembly protein 447237 13699084 O3K_02100 Escherichia coli O104:H4 str. 2011C-3493 putative fimbrial assembly protein YP_006777150.1 446698 D 1133852 CDS YP_006777151.1 407480002 13699085 447221..447661 1 NC_018658.1 hypothetical protein 447661 13699085 O3K_02105 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777151.1 447221 D 1133852 CDS YP_006777152.1 407480003 13699086 447651..448055 1 NC_018658.1 hypothetical protein 448055 13699086 O3K_02110 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777152.1 447651 D 1133852 CDS YP_006777153.1 407480004 13699087 447967..449205 1 NC_018658.1 COG4796 Type II secretory pathway, component HofQ; outer membrane porin HofQ 449205 hofQ 13699087 hofQ Escherichia coli O104:H4 str. 2011C-3493 outer membrane porin HofQ YP_006777153.1 447967 D 1133852 CDS YP_006777154.1 407480005 13699088 449606..450127 1 NC_018658.1 COG0703 Shikimate kinase; shikimate kinase I 450127 aroK 13699088 aroK Escherichia coli O104:H4 str. 2011C-3493 shikimate kinase I YP_006777154.1 449606 D 1133852 CDS YP_006777155.1 407480006 13699089 450184..451272 1 NC_018658.1 COG0337 3-dehydroquinate synthetase; 3-dehydroquinate synthase 451272 aroB 13699089 aroB Escherichia coli O104:H4 str. 2011C-3493 3-dehydroquinate synthase YP_006777155.1 450184 D 1133852 CDS YP_006777156.1 407480007 13699090 451364..452650 1 NC_018658.1 COG3266 Uncharacterized protein conserved in bacteria; cell division protein DamX 452650 13699090 O3K_02130 Escherichia coli O104:H4 str. 2011C-3493 cell division protein DamX YP_006777156.1 451364 D 1133852 CDS YP_006777157.1 407480008 13699091 452757..453593 1 NC_018658.1 COG0338 Site-specific DNA methylase; DNA adenine methylase 453593 13699091 O3K_02135 Escherichia coli O104:H4 str. 2011C-3493 DNA adenine methylase YP_006777157.1 452757 D 1133852 CDS YP_006777158.1 407480009 13699092 453611..454288 1 NC_018658.1 COG0036 Pentose-5-phosphate-3-epimerase; ribulose-phosphate 3-epimerase 454288 13699092 O3K_02140 Escherichia coli O104:H4 str. 2011C-3493 ribulose-phosphate 3-epimerase YP_006777158.1 453611 D 1133852 CDS YP_006777159.1 407480010 13699093 454281..455039 1 NC_018658.1 COG0546 Predicted phosphatases; phosphoglycolate phosphatase 455039 13699093 O3K_02145 Escherichia coli O104:H4 str. 2011C-3493 phosphoglycolate phosphatase YP_006777159.1 454281 D 1133852 CDS YP_006777160.1 407480011 13699094 455032..456036 1 NC_018658.1 COG0180 Tryptophanyl-tRNA synthetase; tryptophanyl-tRNA synthetase 456036 13699094 O3K_02150 Escherichia coli O104:H4 str. 2011C-3493 tryptophanyl-tRNA synthetase YP_006777160.1 455032 D 1133852 CDS YP_006777161.1 407480012 13699095 456305..457210 1 NC_018658.1 hypothetical protein 457210 13699095 O3K_02155 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777161.1 456305 D 1133852 CDS YP_006777162.1 407480013 13699096 457227..457589 1 NC_018658.1 hypothetical protein 457589 13699096 O3K_02160 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777162.1 457227 D 1133852 CDS YP_006777163.1 407480014 13699097 457673..458836 1 NC_018658.1 COG3457 Predicted amino acid racemase; putative amino acid racemase 458836 13699097 O3K_02165 Escherichia coli O104:H4 str. 2011C-3493 putative amino acid racemase YP_006777163.1 457673 D 1133852 CDS YP_006777164.1 407480015 13699098 458836..460062 1 NC_018658.1 COG1015 Phosphopentomutase; putative mutase 460062 13699098 O3K_02170 Escherichia coli O104:H4 str. 2011C-3493 putative mutase YP_006777164.1 458836 D 1133852 CDS YP_006777165.1 407480016 13699099 460059..460937 1 NC_018658.1 COG1735 Predicted metal-dependent hydrolase with the TIM-barrel fold; hydrolase 460937 13699099 O3K_02175 Escherichia coli O104:H4 str. 2011C-3493 hydrolase YP_006777165.1 460059 D 1133852 CDS YP_006777166.1 407480017 13699100 460948..461301 1 NC_018658.1 COG0698 Ribose 5-phosphate isomerase RpiB; hypothetical protein 461301 13699100 O3K_02180 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777166.1 460948 D 1133852 CDS YP_006777167.1 407480018 13699101 461313..462617 1 NC_018658.1 inner membrane protein 462617 13699101 O3K_02185 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006777167.1 461313 D 1133852 CDS YP_006777168.1 407480019 13699102 462629..463714 1 NC_018658.1 hypothetical protein 463714 13699102 O3K_02190 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777168.1 462629 D 1133852 CDS YP_006777169.1 407480020 13699103 complement(463866..464597) 1 NC_018658.1 COG2188 Transcriptional regulators; DNA-binding transcriptional regulator FrlR 464597 13699103 O3K_02195 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator FrlR YP_006777169.1 463866 R 1133852 CDS YP_006777170.1 407480021 13699104 complement(464697..465482) 1 NC_018658.1 COG0524 Sugar kinases, ribokinase family; fructoselysine 6-kinase 465482 13699104 O3K_02200 Escherichia coli O104:H4 str. 2011C-3493 fructoselysine 6-kinase YP_006777170.1 464697 R 1133852 CDS YP_006777171.1 407480022 13699105 complement(465479..466309) 1 NC_018658.1 COG1082 Sugar phosphate isomerases/epimerases; fructoselysine 3-epimerase 466309 13699105 O3K_02205 Escherichia coli O104:H4 str. 2011C-3493 fructoselysine 3-epimerase YP_006777171.1 465479 R 1133852 CDS YP_006777172.1 407480023 13699106 complement(466359..467381) 1 NC_018658.1 COG2222 Predicted phosphosugar isomerases; fructoselysine-6-P-deglycase 467381 frlB 13699106 frlB Escherichia coli O104:H4 str. 2011C-3493 fructoselysine-6-P-deglycase YP_006777172.1 466359 R 1133852 CDS YP_006777173.1 407480024 13699107 complement(467402..468739) 1 NC_018658.1 COG0531 Amino acid transporters; putative fructoselysine transporter 468739 frlA 13699107 frlA Escherichia coli O104:H4 str. 2011C-3493 putative fructoselysine transporter YP_006777173.1 467402 R 1133852 CDS YP_006777174.1 407480025 13699108 complement(469034..469201) 1 NC_018658.1 lipoprotein 469201 13699108 O3K_02220 Escherichia coli O104:H4 str. 2011C-3493 lipoprotein YP_006777174.1 469034 R 1133852 CDS YP_006777175.1 407480026 13699109 complement(469448..470821) 1 NC_018658.1 COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); siroheme synthase 470821 cysG 13699109 cysG Escherichia coli O104:H4 str. 2011C-3493 siroheme synthase YP_006777175.1 469448 R 1133852 CDS YP_006777176.1 407480027 13699110 complement(470840..471646) 1 NC_018658.1 COG2116 Formate/nitrite family of transporters; nitrite transporter NirC 471646 13699110 O3K_02230 Escherichia coli O104:H4 str. 2011C-3493 nitrite transporter NirC YP_006777176.1 470840 R 1133852 CDS YP_006777177.1 407480028 13699111 complement(471773..472099) 1 NC_018658.1 COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases; nitrite reductase small subunit 472099 nirD 13699111 nirD Escherichia coli O104:H4 str. 2011C-3493 nitrite reductase small subunit YP_006777177.1 471773 R 1133852 CDS YP_006777178.1 407480029 13699112 complement(472096..474639) 1 NC_018658.1 COG1251 NAD(P)H-nitrite reductase; nitrite reductase subunit NirD 474639 13699112 O3K_02240 Escherichia coli O104:H4 str. 2011C-3493 nitrite reductase subunit NirD YP_006777178.1 472096 R 1133852 CDS YP_006777179.1 407480030 13699113 complement(474901..476082) 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; transporter 476082 13699113 O3K_02245 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006777179.1 474901 R 1133852 CDS YP_006777180.1 407480031 13699114 476353..476925 1 NC_018658.1 COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family; peptidyl-prolyl cis-trans isomerase A 476925 13699114 O3K_02250 Escherichia coli O104:H4 str. 2011C-3493 peptidyl-prolyl cis-trans isomerase A YP_006777180.1 476353 D 1133852 CDS YP_006777181.1 407480032 13699115 477030..477197 1 NC_018658.1 hypothetical protein 477197 13699115 O3K_02255 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777181.1 477030 D 1133852 CDS YP_006777182.1 407480033 13699116 477187..477789 1 NC_018658.1 COG2184 Protein involved in cell division; cell filamentation protein Fic 477789 13699116 O3K_02260 Escherichia coli O104:H4 str. 2011C-3493 cell filamentation protein Fic YP_006777182.1 477187 D 1133852 CDS YP_006777183.1 407480034 13699117 477821..478384 1 NC_018658.1 COG0512 Anthranilate/para-aminobenzoate synthases component II; para-aminobenzoate synthase component II 478384 13699117 O3K_02265 Escherichia coli O104:H4 str. 2011C-3493 para-aminobenzoate synthase component II YP_006777183.1 477821 D 1133852 CDS YP_006777184.1 407480035 13699118 478470..479690 1 NC_018658.1 COG4992 Ornithine/acetylornithine aminotransferase; bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase 479690 argD 13699118 argD Escherichia coli O104:H4 str. 2011C-3493 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase YP_006777184.1 478470 D 1133852 CDS YP_006777185.1 407480036 13699119 complement(479757..481847) 1 NC_018658.1 COG1289 Predicted membrane protein; hypothetical protein 481847 13699119 O3K_02275 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777185.1 479757 R 1133852 CDS YP_006777186.1 407480037 13699120 complement(481898..482530) 1 NC_018658.1 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases; DNA-binding transcriptional dual regulator Crp 482530 13699120 O3K_02280 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional dual regulator Crp YP_006777186.1 481898 R 1133852 CDS YP_006777187.1 407480038 13699121 482832..483236 1 NC_018658.1 COG1765 Predicted redox protein, regulator of disulfide bond formation; hypothetical protein 483236 13699121 O3K_02285 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777187.1 482832 D 1133852 CDS YP_006777188.1 407480039 13699122 complement(483291..484160) 1 NC_018658.1 COG3954 Phosphoribulokinase; phosphoribulokinase 484160 13699122 O3K_02290 Escherichia coli O104:H4 str. 2011C-3493 phosphoribulokinase YP_006777188.1 483291 R 1133852 CDS YP_006777189.1 407480040 13699123 complement(484214..484432) 1 NC_018658.1 COG3089 Uncharacterized protein conserved in bacteria; hypothetical protein 484432 13699123 O3K_02295 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777189.1 484214 R 1133852 CDS YP_006777190.1 407480041 13699124 complement(484426..485448) 1 NC_018658.1 COG0429 Predicted hydrolase of the alpha/beta-hydrolase fold; hydrolase 485448 13699124 O3K_02300 Escherichia coli O104:H4 str. 2011C-3493 hydrolase YP_006777190.1 484426 R 1133852 CDS YP_006777191.1 407480042 13699125 complement(485448..487361) 1 NC_018658.1 COG0488 ATPase components of ABC transporters with duplicated ATPase domains; ABC transporter ATP-binding protein 487361 13699125 O3K_02305 Escherichia coli O104:H4 str. 2011C-3493 ABC transporter ATP-binding protein YP_006777191.1 485448 R 1133852 CDS YP_006777192.1 407480043 13699126 487492..488043 1 NC_018658.1 COG2249 Putative NADPH-quinone reductase (modulator of drug activity B); glutathione-regulated potassium-efflux system ancillary protein KefG 488043 13699126 O3K_02310 Escherichia coli O104:H4 str. 2011C-3493 glutathione-regulated potassium-efflux system ancillary protein KefG YP_006777192.1 487492 D 1133852 CDS YP_006777193.1 407480044 13699127 488043..489848 1 NC_018658.1 COG0475 Kef-type K+ transport systems, membrane components; glutathione-regulated potassium-efflux system protein KefB 489848 13699127 O3K_02315 Escherichia coli O104:H4 str. 2011C-3493 glutathione-regulated potassium-efflux system protein KefB YP_006777193.1 488043 D 1133852 CDS YP_006777194.1 407480045 13699128 489858..490058 1 NC_018658.1 COG3529 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain; hypothetical protein 490058 13699128 O3K_02320 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777194.1 489858 D 1133852 CDS YP_006777195.1 407480046 13699129 490153..490743 1 NC_018658.1 COG1047 FKBP-type peptidyl-prolyl cis-trans isomerases 2; FKBP-type peptidyl-prolyl cis-trans isomerase 490743 13699129 O3K_02325 Escherichia coli O104:H4 str. 2011C-3493 FKBP-type peptidyl-prolyl cis-trans isomerase YP_006777195.1 490153 D 1133852 CDS YP_006777196.1 407480047 13699130 complement(490792..491010) 1 NC_018658.1 COG2900 Uncharacterized protein conserved in bacteria; phi X174 lysis protein 491010 13699130 O3K_02330 Escherichia coli O104:H4 str. 2011C-3493 phi X174 lysis protein YP_006777196.1 490792 R 1133852 CDS YP_006777197.1 407480048 13699131 491231..492043 1 NC_018658.1 COG0545 FKBP-type peptidyl-prolyl cis-trans isomerases 1; FKBP-type peptidyl-prolyl cis-trans isomerase 492043 13699131 O3K_02335 Escherichia coli O104:H4 str. 2011C-3493 FKBP-type peptidyl-prolyl cis-trans isomerase YP_006777197.1 491231 D 1133852 CDS YP_006777198.1 407480049 13699132 492210..492932 1 NC_018658.1 COG2964 Uncharacterized protein conserved in bacteria; DNA-binding transcriptional regulator 492932 13699132 O3K_02340 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator YP_006777198.1 492210 D 1133852 CDS YP_006777199.1 407480050 13699133 492932..493318 1 NC_018658.1 COG1553 Uncharacterized conserved protein involved in intracellular sulfur reduction; sulfur transfer complex subunit TusD 493318 13699133 O3K_02345 Escherichia coli O104:H4 str. 2011C-3493 sulfur transfer complex subunit TusD YP_006777199.1 492932 D 1133852 CDS YP_006777200.1 407480051 13699134 493318..493677 1 NC_018658.1 COG2923 Uncharacterized protein involved in the oxidation of intracellular sulfur; sulfur relay protein TusC 493677 13699134 O3K_02350 Escherichia coli O104:H4 str. 2011C-3493 sulfur relay protein TusC YP_006777200.1 493318 D 1133852 CDS YP_006777201.1 407480052 13699135 493685..493972 1 NC_018658.1 COG2168 Uncharacterized conserved protein involved in oxidation of intracellular sulfur; sulfur transfer complex subunit TusB 493972 13699135 O3K_02355 Escherichia coli O104:H4 str. 2011C-3493 sulfur transfer complex subunit TusB YP_006777201.1 493685 D 1133852 CDS YP_006777202.1 407480053 13699136 494098..494472 1 NC_018658.1 COG0048 Ribosomal protein S12; 30S ribosomal protein S12 494472 rpsL 13699136 rpsL Escherichia coli O104:H4 str. 2011C-3493 30S ribosomal protein S12 YP_006777202.1 494098 D 1133852 CDS YP_006777203.1 407480054 13699137 494569..495039 1 NC_018658.1 COG0049 Ribosomal protein S7; 30S ribosomal protein S7 495039 13699137 O3K_02365 Escherichia coli O104:H4 str. 2011C-3493 30S ribosomal protein S7 YP_006777203.1 494569 D 1133852 CDS YP_006777204.1 407480055 13699138 495136..497250 1 NC_018658.1 COG0480 Translation elongation factors (GTPases); elongation factor G 497250 13699138 O3K_02370 Escherichia coli O104:H4 str. 2011C-3493 elongation factor G YP_006777204.1 495136 D 1133852 CDS YP_006777205.1 407480056 13699139 497321..498505 1 NC_018658.1 COG0050 GTPases - translation elongation factors; elongation factor Tu 498505 13699139 O3K_02375 Escherichia coli O104:H4 str. 2011C-3493 elongation factor Tu YP_006777205.1 497321 D 1133852 CDS YP_006777206.1 407480057 13699140 498688..498882 1 NC_018658.1 COG2906 Bacterioferritin-associated ferredoxin; bacterioferritin-associated ferredoxin 498882 13699140 O3K_02380 Escherichia coli O104:H4 str. 2011C-3493 bacterioferritin-associated ferredoxin YP_006777206.1 498688 D 1133852 CDS YP_006777207.1 407480058 13699141 498955..499431 1 NC_018658.1 COG2193 Bacterioferritin (cytochrome b1); bacterioferritin 499431 13699141 O3K_02385 Escherichia coli O104:H4 str. 2011C-3493 bacterioferritin YP_006777207.1 498955 D 1133852 CDS YP_006777208.1 407480059 13699142 complement(499428..499895) 1 NC_018658.1 COG1989 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases; bifunctional prepilin peptidase HopD 499895 13699142 O3K_02390 Escherichia coli O104:H4 str. 2011C-3493 bifunctional prepilin peptidase HopD YP_006777208.1 499428 R 1133852 CDS YP_006777209.1 407480060 13699143 500274..500585 1 NC_018658.1 COG0051 Ribosomal protein S10; 30S ribosomal protein S10 500585 rpsJ 13699143 rpsJ Escherichia coli O104:H4 str. 2011C-3493 30S ribosomal protein S10 YP_006777209.1 500274 D 1133852 CDS YP_006777210.1 407480061 13699144 500618..501247 1 NC_018658.1 COG0087 Ribosomal protein L3; 50S ribosomal protein L3 501247 rplC 13699144 rplC Escherichia coli O104:H4 str. 2011C-3493 50S ribosomal protein L3 YP_006777210.1 500618 D 1133852 CDS YP_006777211.1 407480062 13699145 501258..501863 1 NC_018658.1 COG0088 Ribosomal protein L4; 50S ribosomal protein L4 501863 rplD 13699145 rplD Escherichia coli O104:H4 str. 2011C-3493 50S ribosomal protein L4 YP_006777211.1 501258 D 1133852 CDS YP_006777212.1 407480063 13699146 501860..502162 1 NC_018658.1 COG0089 Ribosomal protein L23; 50S ribosomal protein L23 502162 rplW 13699146 rplW Escherichia coli O104:H4 str. 2011C-3493 50S ribosomal protein L23 YP_006777212.1 501860 D 1133852 CDS YP_006777213.1 407480064 13699147 502180..503001 1 NC_018658.1 COG0090 Ribosomal protein L2; 50S ribosomal protein L2 503001 rplB 13699147 rplB Escherichia coli O104:H4 str. 2011C-3493 50S ribosomal protein L2 YP_006777213.1 502180 D 1133852 CDS YP_006777214.1 407480065 13699148 503018..503296 1 NC_018658.1 COG0185 Ribosomal protein S19; 30S ribosomal protein S19 503296 rpsS 13699148 rpsS Escherichia coli O104:H4 str. 2011C-3493 30S ribosomal protein S19 YP_006777214.1 503018 D 1133852 CDS YP_006777215.1 407480066 13699149 503311..503643 1 NC_018658.1 COG0091 Ribosomal protein L22; 50S ribosomal protein L22 503643 rplV 13699149 rplV Escherichia coli O104:H4 str. 2011C-3493 50S ribosomal protein L22 YP_006777215.1 503311 D 1133852 CDS YP_006777216.1 407480067 13699150 503661..504362 1 NC_018658.1 COG0092 Ribosomal protein S3; 30S ribosomal protein S3 504362 rpsC 13699150 rpsC Escherichia coli O104:H4 str. 2011C-3493 30S ribosomal protein S3 YP_006777216.1 503661 D 1133852 CDS YP_006777217.1 407480068 13699151 504375..504785 1 NC_018658.1 COG0197 Ribosomal protein L16/L10E; 50S ribosomal protein L16 504785 rplP 13699151 rplP Escherichia coli O104:H4 str. 2011C-3493 50S ribosomal protein L16 YP_006777217.1 504375 D 1133852 CDS YP_006777218.1 407480069 13699152 504785..504976 1 NC_018658.1 COG0255 Ribosomal protein L29; 50S ribosomal protein L29 504976 13699152 O3K_02440 Escherichia coli O104:H4 str. 2011C-3493 50S ribosomal protein L29 YP_006777218.1 504785 D 1133852 CDS YP_006777219.1 407480070 13699153 504976..505230 1 NC_018658.1 COG0186 Ribosomal protein S17; 30S ribosomal protein S17 505230 rpsQ 13699153 rpsQ Escherichia coli O104:H4 str. 2011C-3493 30S ribosomal protein S17 YP_006777219.1 504976 D 1133852 CDS YP_006777220.1 407480071 13699154 505395..505766 1 NC_018658.1 COG0093 Ribosomal protein L14; 50S ribosomal protein L14 505766 rplN 13699154 rplN Escherichia coli O104:H4 str. 2011C-3493 50S ribosomal protein L14 YP_006777220.1 505395 D 1133852 CDS YP_006777221.1 407480072 13699155 505777..506091 1 NC_018658.1 COG0198 Ribosomal protein L24; 50S ribosomal protein L24 506091 rplX 13699155 rplX Escherichia coli O104:H4 str. 2011C-3493 50S ribosomal protein L24 YP_006777221.1 505777 D 1133852 CDS YP_006777222.1 407480073 13699156 506106..506645 1 NC_018658.1 COG0094 Ribosomal protein L5; 50S ribosomal protein L5 506645 rplE 13699156 rplE Escherichia coli O104:H4 str. 2011C-3493 50S ribosomal protein L5 YP_006777222.1 506106 D 1133852 CDS YP_006777223.1 407480074 13699157 506660..506965 1 NC_018658.1 COG0199 Ribosomal protein S14; 30S ribosomal protein S14 506965 rpsN 13699157 rpsN Escherichia coli O104:H4 str. 2011C-3493 30S ribosomal protein S14 YP_006777223.1 506660 D 1133852 CDS YP_006777224.1 407480075 13699158 506999..507391 1 NC_018658.1 COG0096 Ribosomal protein S8; 30S ribosomal protein S8 507391 rpsH 13699158 rpsH Escherichia coli O104:H4 str. 2011C-3493 30S ribosomal protein S8 YP_006777224.1 506999 D 1133852 CDS YP_006777225.1 407480076 13699159 507404..507937 1 NC_018658.1 COG0097 Ribosomal protein L6P/L9E; 50S ribosomal protein L6 507937 rplF 13699159 rplF Escherichia coli O104:H4 str. 2011C-3493 50S ribosomal protein L6 YP_006777225.1 507404 D 1133852 CDS YP_006777226.1 407480077 13699160 507947..508300 1 NC_018658.1 COG0256 Ribosomal protein L18; 50S ribosomal protein L18 508300 rplR 13699160 rplR Escherichia coli O104:H4 str. 2011C-3493 50S ribosomal protein L18 YP_006777226.1 507947 D 1133852 CDS YP_006777227.1 407480078 13699161 508315..508818 1 NC_018658.1 COG0098 Ribosomal protein S5; 30S ribosomal protein S5 508818 rpsE 13699161 rpsE Escherichia coli O104:H4 str. 2011C-3493 30S ribosomal protein S5 YP_006777227.1 508315 D 1133852 CDS YP_006777228.1 407480079 13699162 508822..509001 1 NC_018658.1 COG1841 Ribosomal protein L30/L7E; 50S ribosomal protein L30 509001 rpmD 13699162 rpmD Escherichia coli O104:H4 str. 2011C-3493 50S ribosomal protein L30 YP_006777228.1 508822 D 1133852 CDS YP_006777229.1 407480080 13699163 509005..509439 1 NC_018658.1 COG0200 Ribosomal protein L15; 50S ribosomal protein L15 509439 rplO 13699163 rplO Escherichia coli O104:H4 str. 2011C-3493 50S ribosomal protein L15 YP_006777229.1 509005 D 1133852 CDS YP_006777230.1 407480081 13699164 509447..510778 1 NC_018658.1 COG0201 Preprotein translocase subunit SecY; preprotein translocase subunit SecY 510778 secY 13699164 secY Escherichia coli O104:H4 str. 2011C-3493 preprotein translocase subunit SecY YP_006777230.1 509447 D 1133852 CDS YP_006777231.1 407480082 13699165 510810..510926 1 NC_018658.1 COG0257 Ribosomal protein L36; 50S ribosomal protein L36 510926 rpmJ 13699165 rpmJ Escherichia coli O104:H4 str. 2011C-3493 50S ribosomal protein L36 YP_006777231.1 510810 D 1133852 CDS YP_006777232.1 407480083 13699166 511073..511429 1 NC_018658.1 COG0099 Ribosomal protein S13; 30S ribosomal protein S13 511429 rpsM 13699166 rpsM Escherichia coli O104:H4 str. 2011C-3493 30S ribosomal protein S13 YP_006777232.1 511073 D 1133852 CDS YP_006777233.1 407480084 13699167 511446..511835 1 NC_018658.1 COG0100 Ribosomal protein S11; 30S ribosomal protein S11 511835 13699167 O3K_02515 Escherichia coli O104:H4 str. 2011C-3493 30S ribosomal protein S11 YP_006777233.1 511446 D 1133852 CDS YP_006777234.1 407480085 13699168 511869..512489 1 NC_018658.1 COG0522 Ribosomal protein S4 and related proteins; 30S ribosomal protein S4 512489 rpsD 13699168 rpsD Escherichia coli O104:H4 str. 2011C-3493 30S ribosomal protein S4 YP_006777234.1 511869 D 1133852 CDS YP_006777235.1 407480086 13699169 512515..513504 1 NC_018658.1 COG0202 DNA-directed RNA polymerase, alpha subunit/40 kD subunit; DNA-directed RNA polymerase subunit alpha 513504 13699169 O3K_02525 Escherichia coli O104:H4 str. 2011C-3493 DNA-directed RNA polymerase subunit alpha YP_006777235.1 512515 D 1133852 CDS YP_006777236.1 407480087 13699170 513545..513928 1 NC_018658.1 COG0203 Ribosomal protein L17; 50S ribosomal protein L17 513928 rplQ 13699170 rplQ Escherichia coli O104:H4 str. 2011C-3493 50S ribosomal protein L17 YP_006777236.1 513545 D 1133852 CDS YP_006777237.1 407480088 13699171 514035..514403 1 NC_018658.1 hypothetical protein 514403 13699171 O3K_02535 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777237.1 514035 D 1133852 CDS YP_006777238.1 407480089 13699172 514414..514839 1 NC_018658.1 COG0789 Predicted transcriptional regulators; zinc-responsive transcriptional regulator 514839 zntR 13699172 zntR Escherichia coli O104:H4 str. 2011C-3493 zinc-responsive transcriptional regulator YP_006777238.1 514414 D 1133852 CDS YP_006777239.1 407480090 13699173 514895..515113 1 NC_018658.1 COG3036 Uncharacterized protein conserved in bacteria; hypothetical protein 515113 13699173 O3K_02545 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777239.1 514895 D 1133852 CDS YP_006777240.1 407480091 13699174 complement(515110..515520) 1 NC_018658.1 COG1970 Large-conductance mechanosensitive channel; large conductance mechanosensitive channel protein 515520 mscL 13699174 mscL Escherichia coli O104:H4 str. 2011C-3493 large conductance mechanosensitive channel protein YP_006777240.1 515110 R 1133852 CDS YP_006777241.1 407480092 13699175 complement(515650..517026) 1 NC_018658.1 COG0569 K+ transport systems, NAD-binding component; potassium transporter peripheral membrane protein 517026 trkA 13699175 trkA Escherichia coli O104:H4 str. 2011C-3493 potassium transporter peripheral membrane protein YP_006777241.1 515650 R 1133852 CDS YP_006777242.1 407480093 13699176 complement(517048..518337) 1 NC_018658.1 COG0144 tRNA and rRNA cytosine-C5-methylases; 16S rRNA methyltransferase B 518337 13699176 O3K_02560 Escherichia coli O104:H4 str. 2011C-3493 16S rRNA methyltransferase B YP_006777242.1 517048 R 1133852 CDS YP_006777243.1 407480094 13699177 complement(518383..519330) 1 NC_018658.1 COG0223 Methionyl-tRNA formyltransferase; methionyl-tRNA formyltransferase 519330 fmt 13699177 fmt Escherichia coli O104:H4 str. 2011C-3493 methionyl-tRNA formyltransferase YP_006777243.1 518383 R 1133852 CDS YP_006777244.1 407480095 13699178 complement(519345..519854) 1 NC_018658.1 COG0242 N-formylmethionyl-tRNA deformylase; peptide deformylase 519854 def 13699178 def Escherichia coli O104:H4 str. 2011C-3493 peptide deformylase YP_006777244.1 519345 R 1133852 CDS YP_006777245.1 407480096 13699179 519984..521108 1 NC_018658.1 COG0758 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake; hypothetical protein 521108 13699179 O3K_02575 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777245.1 519984 D 1133852 CDS YP_006777246.1 407480097 13699180 521080..521553 1 NC_018658.1 COG2922 Uncharacterized protein conserved in bacteria; hypothetical protein 521553 13699180 O3K_02580 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777246.1 521080 D 1133852 CDS YP_006777247.1 407480098 13699181 521582..522124 1 NC_018658.1 COG0551 Zn-finger domain associated with topoisomerase type I; putative DNA topoisomerase 522124 13699181 O3K_02585 Escherichia coli O104:H4 str. 2011C-3493 putative DNA topoisomerase YP_006777247.1 521582 D 1133852 CDS YP_006777248.1 407480099 13699182 522129..522701 1 NC_018658.1 COG0009 Putative translation factor (SUA5); tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein 522701 13699182 O3K_02590 Escherichia coli O104:H4 str. 2011C-3493 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein YP_006777248.1 522129 D 1133852 CDS YP_006777249.1 407480100 13699183 522706..523524 1 NC_018658.1 COG0169 Shikimate 5-dehydrogenase; shikimate 5-dehydrogenase 523524 aroE 13699183 aroE Escherichia coli O104:H4 str. 2011C-3493 shikimate 5-dehydrogenase YP_006777249.1 522706 D 1133852 CDS YP_006777250.1 407480101 13699184 523521..523778 1 NC_018658.1 hypothetical protein 523778 13699184 O3K_02600 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777250.1 523521 D 1133852 CDS YP_006777251.1 407480102 13699185 complement(523754..524308) 1 NC_018658.1 COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily; hypothetical protein 524308 13699185 O3K_02605 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777251.1 523754 R 1133852 CDS YP_006777252.1 407480103 13699193 complement(530360..531118) 1 NC_018658.1 COG1126 ABC-type polar amino acid transport system, ATPase component; phosphate ABC transporter ATP-binding protein 531118 13699193 O3K_02610 Escherichia coli O104:H4 str. 2011C-3493 phosphate ABC transporter ATP-binding protein YP_006777252.1 530360 R 1133852 CDS YP_006777253.1 407480104 13699194 complement(531126..532229) 1 NC_018658.1 COG0765 ABC-type amino acid transport system, permease component; amino acid ABC transporter permease 532229 13699194 O3K_02615 Escherichia coli O104:H4 str. 2011C-3493 amino acid ABC transporter permease YP_006777253.1 531126 R 1133852 CDS YP_006777254.1 407480105 13699195 complement(532239..533420) 1 NC_018658.1 COG4597 ABC-type amino acid transport system, permease component; transport system permease 533420 13699195 O3K_02620 Escherichia coli O104:H4 str. 2011C-3493 transport system permease YP_006777254.1 532239 R 1133852 CDS YP_006777255.1 407480106 13699196 complement(533488..534513) 1 NC_018658.1 COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; amino acid ABC transporter substrate-binding protein 534513 13699196 O3K_02625 Escherichia coli O104:H4 str. 2011C-3493 amino acid ABC transporter substrate-binding protein YP_006777255.1 533488 R 1133852 CDS YP_006777256.1 407480107 13699197 complement(534944..535165) 1 NC_018658.1 hypothetical protein 535165 13699197 O3K_02630 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777256.1 534944 R 1133852 CDS YP_006777257.1 407480108 13699198 complement(535418..538522) 1 NC_018658.1 COG0841 Cation/multidrug efflux pump; acriflavine resistance protein 538522 13699198 O3K_02635 Escherichia coli O104:H4 str. 2011C-3493 acriflavine resistance protein YP_006777257.1 535418 R 1133852 CDS YP_006777258.1 407480109 13699199 complement(538534..539691) 1 NC_018658.1 COG0845 Membrane-fusion protein; hypothetical protein 539691 13699199 O3K_02640 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777258.1 538534 R 1133852 CDS YP_006777259.1 407480110 13699200 540090..540752 1 NC_018658.1 COG1309 Transcriptional regulator; DNA-binding transcriptional regulator EnvR 540752 13699200 O3K_02645 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator EnvR YP_006777259.1 540090 D 1133852 CDS YP_006777260.1 407480111 13699201 complement(540755..540934) 1 NC_018658.1 hypothetical protein 540934 13699201 O3K_02650 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777260.1 540755 R 1133852 CDS YP_006777261.1 407480112 13699202 complement(541018..541902) 1 NC_018658.1 COG0863 DNA modification methylase; methyltransferase 541902 13699202 O3K_02655 Escherichia coli O104:H4 str. 2011C-3493 methyltransferase YP_006777261.1 541018 R 1133852 CDS YP_006777262.1 407480113 13699203 complement(541988..542284) 1 NC_018658.1 COG2901 Factor for inversion stimulation Fis, transcriptional activator; global DNA-binding transcriptional dual regulator Fis 542284 fis 13699203 fis Escherichia coli O104:H4 str. 2011C-3493 global DNA-binding transcriptional dual regulator Fis YP_006777262.1 541988 R 1133852 CDS YP_006777263.1 407480114 13699204 complement(542310..543275) 1 NC_018658.1 COG0042 tRNA-dihydrouridine synthase; tRNA-dihydrouridine synthase B 543275 13699204 O3K_02665 Escherichia coli O104:H4 str. 2011C-3493 tRNA-dihydrouridine synthase B YP_006777263.1 542310 R 1133852 CDS YP_006777264.1 407480115 13699205 complement(543604..544485) 1 NC_018658.1 COG2264 Ribosomal protein L11 methylase; 50S ribosomal protein L11 methyltransferase 544485 prmA 13699205 prmA Escherichia coli O104:H4 str. 2011C-3493 50S ribosomal protein L11 methyltransferase YP_006777264.1 543604 R 1133852 CDS YP_006777265.1 407480116 13699206 complement(544497..545948) 1 NC_018658.1 COG4145 Na+/panthothenate symporter; sodium/panthothenate symporter 545948 panF 13699206 panF Escherichia coli O104:H4 str. 2011C-3493 sodium/panthothenate symporter YP_006777265.1 544497 R 1133852 CDS YP_006777266.1 407480117 13699207 complement(545938..546180) 1 NC_018658.1 COG3924 Predicted membrane protein; hypothetical protein 546180 13699207 O3K_02680 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777266.1 545938 R 1133852 CDS YP_006777267.1 407480118 13699208 complement(546289..547638) 1 NC_018658.1 COG0439 Biotin carboxylase; acetyl-CoA carboxylase biotin carboxylase subunit 547638 13699208 O3K_02685 Escherichia coli O104:H4 str. 2011C-3493 acetyl-CoA carboxylase biotin carboxylase subunit YP_006777267.1 546289 R 1133852 CDS YP_006777268.1 407480119 13699209 complement(547649..548119) 1 NC_018658.1 COG0511 Biotin carboxyl carrier protein; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 548119 13699209 O3K_02690 Escherichia coli O104:H4 str. 2011C-3493 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit YP_006777268.1 547649 R 1133852 CDS YP_006777269.1 407480120 13699210 complement(548524..548688) 1 NC_018658.1 COG2717 Predicted membrane protein; hypothetical protein 548688 13699210 O3K_02695 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777269.1 548524 R 1133852 CDS YP_006777270.1 407480121 13699211 complement(549097..550071) 1 NC_018658.1 COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases; quinone oxidoreductase 550071 13699211 O3K_02700 Escherichia coli O104:H4 str. 2011C-3493 quinone oxidoreductase YP_006777270.1 549097 R 1133852 CDS YP_006777271.1 407480122 13699212 550223..552163 1 NC_018658.1 COG2199 FOG: GGDEF domain; regulatory protein CsrD 552163 13699212 O3K_02705 Escherichia coli O104:H4 str. 2011C-3493 regulatory protein CsrD YP_006777271.1 550223 D 1133852 CDS YP_006777272.1 407480123 13699213 552468..553511 1 NC_018658.1 COG1077 Actin-like ATPase involved in cell morphogenesis; rod shape-determining protein MreB 553511 13699213 O3K_02710 Escherichia coli O104:H4 str. 2011C-3493 rod shape-determining protein MreB YP_006777272.1 552468 D 1133852 CDS YP_006777273.1 407480124 13699214 553577..554680 1 NC_018658.1 COG1792 Cell shape-determining protein; rod shape-determining protein MreC 554680 13699214 O3K_02715 Escherichia coli O104:H4 str. 2011C-3493 rod shape-determining protein MreC YP_006777273.1 553577 D 1133852 CDS YP_006777274.1 407480125 13699215 554565..554696 1 NC_018658.1 hypothetical protein 554696 13699215 O3K_02720 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777274.1 554565 D 1133852 CDS YP_006777275.1 407480126 13699216 554680..555168 1 NC_018658.1 COG2891 Cell shape-determining protein; rod shape-determining protein MreD 555168 13699216 O3K_02725 Escherichia coli O104:H4 str. 2011C-3493 rod shape-determining protein MreD YP_006777275.1 554680 D 1133852 CDS YP_006777276.1 407480127 13699217 555177..555770 1 NC_018658.1 COG0424 Nucleotide-binding protein implicated in inhibition of septum formation; Maf-like protein 555770 13699217 O3K_02730 Escherichia coli O104:H4 str. 2011C-3493 Maf-like protein YP_006777276.1 555177 D 1133852 CDS YP_006777277.1 407480128 13699218 555760..557229 1 NC_018658.1 COG1530 Ribonucleases G and E; ribonuclease G 557229 13699218 O3K_02735 Escherichia coli O104:H4 str. 2011C-3493 ribonuclease G YP_006777277.1 555760 D 1133852 CDS YP_006777278.1 407480129 13699219 557297..561097 1 NC_018658.1 COG3164 Predicted membrane protein; hypothetical protein 561097 13699219 O3K_02740 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777278.1 557297 D 1133852 CDS YP_006777279.1 407480130 13699220 561253..562698 1 NC_018658.1 COG0312 Predicted Zn-dependent proteases and their inactivated homologs; protease TldD 562698 tldD 13699220 tldD Escherichia coli O104:H4 str. 2011C-3493 protease TldD YP_006777279.1 561253 D 1133852 CDS YP_006777280.1 407480131 13699221 complement(562826..563755) 1 NC_018658.1 COG0583 Transcriptional regulator; transcriptional regulator 563755 13699221 O3K_02750 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator YP_006777280.1 562826 R 1133852 CDS YP_006777281.1 407480132 13699222 563938..564141 1 NC_018658.1 efflux system membrane protein 564141 13699222 O3K_02755 Escherichia coli O104:H4 str. 2011C-3493 efflux system membrane protein YP_006777281.1 563938 D 1133852 CDS YP_006777282.1 407480133 13699223 564149..565081 1 NC_018658.1 COG1566 Multidrug resistance efflux pump; p-hydroxybenzoic acid efflux subunit AaeA 565081 13699223 O3K_02760 Escherichia coli O104:H4 str. 2011C-3493 p-hydroxybenzoic acid efflux subunit AaeA YP_006777282.1 564149 D 1133852 CDS YP_006777283.1 407480134 13699224 565087..567054 1 NC_018658.1 COG1289 Predicted membrane protein; p-hydroxybenzoic acid efflux subunit AaeB 567054 13699224 O3K_02765 Escherichia coli O104:H4 str. 2011C-3493 p-hydroxybenzoic acid efflux subunit AaeB YP_006777283.1 565087 D 1133852 CDS YP_006777284.1 407480135 13699225 567146..567418 1 NC_018658.1 COG2732 Barstar, RNAse (barnase) inhibitor; putative barnase inhibitor 567418 13699225 O3K_02770 Escherichia coli O104:H4 str. 2011C-3493 putative barnase inhibitor YP_006777284.1 567146 D 1133852 CDS YP_006777285.1 407480136 13699226 complement(567474..567737) 1 NC_018658.1 hypothetical protein 567737 13699226 O3K_02775 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777285.1 567474 R 1133852 CDS YP_006777286.1 407480137 13699227 complement(568102..568572) 1 NC_018658.1 COG1438 Arginine repressor; arginine repressor 568572 13699227 O3K_02780 Escherichia coli O104:H4 str. 2011C-3493 arginine repressor YP_006777286.1 568102 R 1133852 CDS YP_006777287.1 407480138 13699228 569007..569945 1 NC_018658.1 COG0039 Malate/lactate dehydrogenases; malate dehydrogenase 569945 13699228 O3K_02785 Escherichia coli O104:H4 str. 2011C-3493 malate dehydrogenase YP_006777287.1 569007 D 1133852 CDS YP_006777288.1 407480139 13699229 complement(570008..571075) 1 NC_018658.1 COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain; serine endoprotease 571075 13699229 O3K_02790 Escherichia coli O104:H4 str. 2011C-3493 serine endoprotease YP_006777288.1 570008 R 1133852 CDS YP_006777289.1 407480140 13699230 complement(571165..572532) 1 NC_018658.1 COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain; serine endoprotease 572532 13699230 O3K_02795 Escherichia coli O104:H4 str. 2011C-3493 serine endoprotease YP_006777289.1 571165 R 1133852 CDS YP_006777290.1 407480141 13699231 complement(572686..573084) 1 NC_018658.1 COG3105 Uncharacterized protein conserved in bacteria; hypothetical protein 573084 13699231 O3K_02800 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777290.1 572686 R 1133852 CDS YP_006777291.1 407480142 13699232 573278..574405 1 NC_018658.1 nucleoside triphosphate hydrolase; COG1485 Predicted ATPase; ATPase 574405 13699232 O3K_02805 Escherichia coli O104:H4 str. 2011C-3493 ATPase YP_006777291.1 573278 D 1133852 CDS YP_006777292.1 407480143 13699233 574624..575052 1 NC_018658.1 COG0102 Ribosomal protein L13; 50S ribosomal protein L13 575052 rplM 13699233 rplM Escherichia coli O104:H4 str. 2011C-3493 50S ribosomal protein L13 YP_006777292.1 574624 D 1133852 CDS YP_006777293.1 407480144 13699234 575068..575460 1 NC_018658.1 COG0103 Ribosomal protein S9; 30S ribosomal protein S9 575460 rpsI 13699234 rpsI Escherichia coli O104:H4 str. 2011C-3493 30S ribosomal protein S9 YP_006777293.1 575068 D 1133852 CDS YP_006777294.1 407480145 13699235 575855..576493 1 NC_018658.1 COG0625 Glutathione S-transferase; stringent starvation protein A 576493 sspA 13699235 sspA Escherichia coli O104:H4 str. 2011C-3493 stringent starvation protein A YP_006777294.1 575855 D 1133852 CDS YP_006777295.1 407480146 13699236 576499..576996 1 NC_018658.1 COG2969 Stringent starvation protein B; ClpXP protease specificity-enhancing factor 576996 13699236 O3K_02825 Escherichia coli O104:H4 str. 2011C-3493 ClpXP protease specificity-enhancing factor YP_006777295.1 576499 D 1133852 CDS YP_006777296.1 407480147 13699237 complement(577039..578406) 1 NC_018658.1 COG3069 C4-dicarboxylate transporter; putative cryptic C4-dicarboxylate transporter DcuD 578406 13699237 O3K_02830 Escherichia coli O104:H4 str. 2011C-3493 putative cryptic C4-dicarboxylate transporter DcuD YP_006777296.1 577039 R 1133852 CDS YP_006777297.1 407480148 13699238 578786..579577 1 NC_018658.1 COG2186 Transcriptional regulators; transcriptional regulator NanR 579577 13699238 O3K_02835 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator NanR YP_006777297.1 578786 D 1133852 CDS YP_006777298.1 407480149 13699239 579699..580592 1 NC_018658.1 COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase; N-acetylneuraminate lyase 580592 13699239 O3K_02840 Escherichia coli O104:H4 str. 2011C-3493 N-acetylneuraminate lyase YP_006777298.1 579699 D 1133852 CDS YP_006777299.1 407480150 13699240 580701..582191 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; putative sialic acid transporter 582191 13699240 O3K_02845 Escherichia coli O104:H4 str. 2011C-3493 putative sialic acid transporter YP_006777299.1 580701 D 1133852 CDS YP_006777300.1 407480151 13699241 582239..582928 1 NC_018658.1 COG3010 Putative N-acetylmannosamine-6-phosphate epimerase; N-acetylmannosamine-6-phosphate 2-epimerase 582928 13699241 O3K_02850 Escherichia coli O104:H4 str. 2011C-3493 N-acetylmannosamine-6-phosphate 2-epimerase YP_006777300.1 582239 D 1133852 CDS YP_006777301.1 407480152 13699242 582925..583800 1 NC_018658.1 COG1940 Transcriptional regulator/sugar kinase; N-acetylmannosamine kinase 583800 13699242 O3K_02855 Escherichia coli O104:H4 str. 2011C-3493 N-acetylmannosamine kinase YP_006777301.1 582925 D 1133852 CDS YP_006777302.1 407480153 13699243 583797..584261 1 NC_018658.1 COG2731 Beta-galactosidase, beta subunit; hypothetical protein 584261 13699243 O3K_02860 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777302.1 583797 D 1133852 CDS YP_006777303.1 407480154 13699244 complement(584337..584642) 1 NC_018658.1 IS600 orf 584642 13699244 O3K_02865 Escherichia coli O104:H4 str. 2011C-3493 IS600 orf YP_006777303.1 584337 R 1133852 CDS YP_006777304.1 407480155 13699245 complement(584659..585138) 1 NC_018658.1 COG4804 Uncharacterized conserved protein; hypothetical protein 585138 13699245 O3K_02870 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777304.1 584659 R 1133852 CDS YP_006777305.1 407480156 13699246 complement(585322..586740) 1 NC_018658.1 COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases; glutamate synthase subunit beta 586740 gltD 13699246 gltD Escherichia coli O104:H4 str. 2011C-3493 glutamate synthase subunit beta YP_006777305.1 585322 R 1133852 CDS YP_006777306.1 407480157 13699247 complement(586753..591213) 1 NC_018658.1 COG0067 Glutamate synthase domain 1; glutamate synthase subunit alpha 591213 gltB 13699247 gltB Escherichia coli O104:H4 str. 2011C-3493 glutamate synthase subunit alpha YP_006777306.1 586753 R 1133852 CDS YP_006777307.1 407480158 13699248 591888..592817 1 NC_018658.1 COG1242 Predicted Fe-S oxidoreductase; Fe-S oxidoreductase 592817 13699248 O3K_02885 Escherichia coli O104:H4 str. 2011C-3493 Fe-S oxidoreductase YP_006777307.1 591888 D 1133852 CDS YP_006777308.1 407480159 13699249 592913..595249 1 NC_018658.1 COG0642 Signal transduction histidine kinase; aerobic respiration control sensor protein ArcB 595249 13699249 O3K_02890 Escherichia coli O104:H4 str. 2011C-3493 aerobic respiration control sensor protein ArcB YP_006777308.1 592913 D 1133852 CDS YP_006777309.1 407480160 13699250 595479..596132 1 NC_018658.1 COG3155 Uncharacterized protein involved in an early stage of isoprenoid biosynthesis; isoprenoid biosynthesis protein 596132 13699250 O3K_02895 Escherichia coli O104:H4 str. 2011C-3493 isoprenoid biosynthesis protein YP_006777309.1 595479 D 1133852 CDS YP_006777310.1 407480161 13699251 596129..596857 1 NC_018658.1 COG0744 Membrane carboxypeptidase (penicillin-binding protein); monofunctional biosynthetic peptidoglycan transglycosylase 596857 mtgA 13699251 mtgA Escherichia coli O104:H4 str. 2011C-3493 monofunctional biosynthetic peptidoglycan transglycosylase YP_006777310.1 596129 D 1133852 CDS YP_006777311.1 407480162 13699252 complement(596854..597486) 1 NC_018658.1 hypothetical protein 597486 13699252 O3K_02905 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777311.1 596854 R 1133852 CDS YP_006777312.1 407480163 13699253 complement(597699..597971) 1 NC_018658.1 COG1925 Phosphotransferase system, HPr-related proteins; PTS system phosphohistidinoprotein-hexose phosphotransferase Npr 597971 13699253 O3K_02910 Escherichia coli O104:H4 str. 2011C-3493 PTS system phosphohistidinoprotein-hexose phosphotransferase Npr YP_006777312.1 597699 R 1133852 CDS YP_006777313.1 407480164 13699254 complement(597968..598822) 1 NC_018658.1 COG1660 Predicted P-loop-containing kinase; glmZ(sRNA)-inactivating NTPase 598822 13699254 O3K_02915 Escherichia coli O104:H4 str. 2011C-3493 glmZ(sRNA)-inactivating NTPase YP_006777313.1 597968 R 1133852 CDS YP_006777314.1 407480165 13699255 complement(598868..599359) 1 NC_018658.1 COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type); PTS system sugar transporter subunit IIA 599359 13699255 O3K_02920 Escherichia coli O104:H4 str. 2011C-3493 PTS system sugar transporter subunit IIA YP_006777314.1 598868 R 1133852 CDS YP_006777315.1 407480166 13699256 complement(599477..599764) 1 NC_018658.1 COG1544 Ribosome-associated protein Y (PSrp-1); ribosome hibernation promoting factor HPF 599764 13699256 O3K_02925 Escherichia coli O104:H4 str. 2011C-3493 ribosome hibernation promoting factor HPF YP_006777315.1 599477 R 1133852 CDS YP_006777316.1 407480167 13699257 complement(599787..601220) 1 NC_018658.1 COG1508 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog; RNA polymerase factor sigma-54 601220 13699257 O3K_02930 Escherichia coli O104:H4 str. 2011C-3493 RNA polymerase factor sigma-54 YP_006777316.1 599787 R 1133852 CDS YP_006777317.1 407480168 13699258 complement(601268..601993) 1 NC_018658.1 COG1137 ABC-type (unclassified) transport system, ATPase component; lipopolysaccharide ABC transporter ATP-binding protein 601993 13699258 O3K_02935 Escherichia coli O104:H4 str. 2011C-3493 lipopolysaccharide ABC transporter ATP-binding protein YP_006777317.1 601268 R 1133852 CDS YP_006777318.1 407480169 13699259 complement(602000..602557) 1 NC_018658.1 COG1934 Uncharacterized protein conserved in bacteria; lipopolysaccharide transport periplasmic protein LptA 602557 13699259 O3K_02940 Escherichia coli O104:H4 str. 2011C-3493 lipopolysaccharide transport periplasmic protein LptA YP_006777318.1 602000 R 1133852 CDS YP_006777319.1 407480170 13699260 complement(602526..603101) 1 NC_018658.1 COG3117 Uncharacterized protein conserved in bacteria; lipopolysaccharide exporter periplasmic protein 603101 13699260 O3K_02945 Escherichia coli O104:H4 str. 2011C-3493 lipopolysaccharide exporter periplasmic protein YP_006777319.1 602526 R 1133852 CDS YP_006777320.1 407480171 13699261 complement(603098..603664) 1 NC_018658.1 COG1778 Low specificity phosphatase (HAD superfamily); 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase 603664 13699261 O3K_02950 Escherichia coli O104:H4 str. 2011C-3493 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase YP_006777320.1 603098 R 1133852 CDS YP_006777321.1 407480172 13699262 complement(603685..604671) 1 NC_018658.1 COG0794 Predicted sugar phosphate isomerase involved in capsule formation; D-arabinose 5-phosphate isomerase 604671 13699262 O3K_02955 Escherichia coli O104:H4 str. 2011C-3493 D-arabinose 5-phosphate isomerase YP_006777321.1 603685 R 1133852 CDS YP_006777322.1 407480173 13699263 complement(604685..605662) 1 NC_018658.1 COG0530 Ca2+/Na+ antiporter; putative calcium/sodium:proton antiporter 605662 13699263 O3K_02960 Escherichia coli O104:H4 str. 2011C-3493 putative calcium/sodium:proton antiporter YP_006777322.1 604685 R 1133852 CDS YP_006777323.1 407480174 13699264 605872..606681 1 NC_018658.1 COG1127 ABC-type transport system involved in resistance to organic solvents, ATPase component; ABC transporter ATP-binding protein YrbF 606681 13699264 O3K_02965 Escherichia coli O104:H4 str. 2011C-3493 ABC transporter ATP-binding protein YrbF YP_006777323.1 605872 D 1133852 CDS YP_006777324.1 407480175 13699265 606689..607471 1 NC_018658.1 COG0767 ABC-type transport system involved in resistance to organic solvents, permease component; toluene ABC transporter permease 607471 13699265 O3K_02970 Escherichia coli O104:H4 str. 2011C-3493 toluene ABC transporter permease YP_006777324.1 606689 D 1133852 CDS YP_006777325.1 407480176 13699266 607476..608027 1 NC_018658.1 COG1463 ABC-type transport system involved in resistance to organic solvents, periplasmic component; hypothetical protein 608027 13699266 O3K_02975 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777325.1 607476 D 1133852 CDS YP_006777326.1 407480177 13699267 608046..608681 1 NC_018658.1 COG2854 ABC-type transport system involved in resistance to organic solvents, auxiliary component; ABC transporter substrate-binding protein MlaC 608681 13699267 O3K_02980 Escherichia coli O104:H4 str. 2011C-3493 ABC transporter substrate-binding protein MlaC YP_006777326.1 608046 D 1133852 CDS YP_006777327.1 407480178 13699268 608681..608974 1 NC_018658.1 COG3113 Predicted NTP binding protein (contains STAS domain); hypothetical protein 608974 13699268 O3K_02985 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777327.1 608681 D 1133852 CDS YP_006777328.1 407480179 13699269 609134..609388 1 NC_018658.1 COG5007 Predicted transcriptional regulator, BolA superfamily; putative DNA-binding transcriptional regulator 609388 13699269 O3K_02990 Escherichia coli O104:H4 str. 2011C-3493 putative DNA-binding transcriptional regulator YP_006777328.1 609134 D 1133852 CDS YP_006777329.1 407480180 13699270 609443..610702 1 NC_018658.1 COG0766 UDP-N-acetylglucosamine enolpyruvyl transferase; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 610702 13699270 O3K_02995 Escherichia coli O104:H4 str. 2011C-3493 UDP-N-acetylglucosamine 1-carboxyvinyltransferase YP_006777329.1 609443 D 1133852 CDS YP_006777330.1 407480181 13699271 complement(610750..611028) 1 NC_018658.1 COG3423 Predicted transcriptional regulator; DNA-binding transcriptional regulator Nlp 611028 13699271 O3K_03000 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator Nlp YP_006777330.1 610750 R 1133852 CDS YP_006777331.1 407480182 13699272 complement(611256..612227) 1 NC_018658.1 COG0142 Geranylgeranyl pyrophosphate synthase; octaprenyl diphosphate synthase 612227 13699272 O3K_03005 Escherichia coli O104:H4 str. 2011C-3493 octaprenyl diphosphate synthase YP_006777331.1 611256 R 1133852 CDS YP_006777332.1 407480183 13699273 612486..612797 1 NC_018658.1 COG0261 Ribosomal protein L21; 50S ribosomal protein L21 612797 rplU 13699273 rplU Escherichia coli O104:H4 str. 2011C-3493 50S ribosomal protein L21 YP_006777332.1 612486 D 1133852 CDS YP_006777333.1 407480184 13699274 612818..613075 1 NC_018658.1 COG0211 Ribosomal protein L27; 50S ribosomal protein L27 613075 rpmA 13699274 rpmA Escherichia coli O104:H4 str. 2011C-3493 50S ribosomal protein L27 YP_006777333.1 612818 D 1133852 CDS YP_006777334.1 407480185 13699275 613202..614167 1 NC_018658.1 COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; hypothetical protein 614167 13699275 O3K_03020 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777334.1 613202 D 1133852 CDS YP_006777335.1 407480186 13699276 614183..615355 1 NC_018658.1 COG0536 Predicted GTPase; GTPase CgtA 615355 obgE 13699276 obgE Escherichia coli O104:H4 str. 2011C-3493 GTPase CgtA YP_006777335.1 614183 D 1133852 CDS YP_006777336.1 407480187 13699277 complement(615395..616828) 1 NC_018658.1 COG2027 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4); D-alanyl-D-alanine carboxypeptidase 616828 13699277 O3K_03030 Escherichia coli O104:H4 str. 2011C-3493 D-alanyl-D-alanine carboxypeptidase YP_006777336.1 615395 R 1133852 CDS YP_006777337.1 407480188 13699278 617076..617552 1 NC_018658.1 COG0782 Transcription elongation factor; transcription elongation factor GreA 617552 greA 13699278 greA Escherichia coli O104:H4 str. 2011C-3493 transcription elongation factor GreA YP_006777337.1 617076 D 1133852 CDS YP_006777338.1 407480189 13699279 complement(617708..618001) 1 NC_018658.1 COG1534 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein; RNA-binding protein YhbY 618001 13699279 O3K_03040 Escherichia coli O104:H4 str. 2011C-3493 RNA-binding protein YhbY YP_006777338.1 617708 R 1133852 CDS YP_006777339.1 407480190 13699280 618127..618756 1 NC_018658.1 COG0293 23S rRNA methylase; 23S rRNA methyltransferase J 618756 rrmJ 13699280 rrmJ Escherichia coli O104:H4 str. 2011C-3493 23S rRNA methyltransferase J YP_006777339.1 618127 D 1133852 CDS YP_006777340.1 407480191 13699281 618856..620790 1 NC_018658.1 COG0465 ATP-dependent Zn proteases; ATP-dependent metalloprotease 620790 hflB 13699281 hflB Escherichia coli O104:H4 str. 2011C-3493 ATP-dependent metalloprotease YP_006777340.1 618856 D 1133852 CDS YP_006777341.1 407480192 13699282 620880..621728 1 NC_018658.1 COG0294 Dihydropteroate synthase and related enzymes; dihydropteroate synthase 621728 folP 13699282 folP Escherichia coli O104:H4 str. 2011C-3493 dihydropteroate synthase YP_006777341.1 620880 D 1133852 CDS YP_006777342.1 407480193 13699283 621721..623058 1 NC_018658.1 COG1109 Phosphomannomutase; phosphoglucosamine mutase 623058 glmM 13699283 glmM Escherichia coli O104:H4 str. 2011C-3493 phosphoglucosamine mutase YP_006777342.1 621721 D 1133852 CDS YP_006777343.1 407480194 13699284 623286..623618 1 NC_018658.1 COG1314 Preprotein translocase subunit SecG; preprotein translocase subunit SecG 623618 secG 13699284 secG Escherichia coli O104:H4 str. 2011C-3493 preprotein translocase subunit SecG YP_006777343.1 623286 D 1133852 CDS YP_006777344.1 407480195 13699286 624176..625801 1 NC_018658.1 COG2194 Predicted membrane-associated, metal-dependent hydrolase; hydrolase, inner membrane 625801 13699286 O3K_03070 Escherichia coli O104:H4 str. 2011C-3493 hydrolase, inner membrane YP_006777344.1 624176 D 1133852 CDS YP_006777345.1 407480196 13699287 complement(625809..627152) 1 NC_018658.1 COG0137 Argininosuccinate synthase; argininosuccinate synthase 627152 13699287 O3K_03075 Escherichia coli O104:H4 str. 2011C-3493 argininosuccinate synthase YP_006777345.1 625809 R 1133852 CDS YP_006777346.1 407480197 13699289 627783..628235 1 NC_018658.1 COG0779 Uncharacterized protein conserved in bacteria; ribosome maturation protein RimP 628235 13699289 O3K_03080 Escherichia coli O104:H4 str. 2011C-3493 ribosome maturation protein RimP YP_006777346.1 627783 D 1133852 CDS YP_006777347.1 407480198 13699290 628263..629750 1 NC_018658.1 COG0195 Transcription elongation factor; transcription elongation factor NusA 629750 nusA 13699290 nusA Escherichia coli O104:H4 str. 2011C-3493 transcription elongation factor NusA YP_006777347.1 628263 D 1133852 CDS YP_006777348.1 407480199 13699291 629775..632447 1 NC_018658.1 COG0532 Translation initiation factor 2 (IF-2; GTPase); translation initiation factor IF-2 632447 infB 13699291 infB Escherichia coli O104:H4 str. 2011C-3493 translation initiation factor IF-2 YP_006777348.1 629775 D 1133852 CDS YP_006777349.1 407480200 13699292 632611..633012 1 NC_018658.1 COG0858 Ribosome-binding factor A; ribosome-binding factor A 633012 rbfA 13699292 rbfA Escherichia coli O104:H4 str. 2011C-3493 ribosome-binding factor A YP_006777349.1 632611 D 1133852 CDS YP_006777350.1 407480201 13700297 633012..633956 1 NC_018658.1 COG0130 Pseudouridine synthase; tRNA pseudouridine synthase B 633956 truB 13700297 truB Escherichia coli O104:H4 str. 2011C-3493 tRNA pseudouridine synthase B YP_006777350.1 633012 D 1133852 CDS YP_006777351.1 407480202 13700298 634105..634374 1 NC_018658.1 COG0184 Ribosomal protein S15P/S13E; 30S ribosomal protein S15 634374 rpsO 13700298 rpsO Escherichia coli O104:H4 str. 2011C-3493 30S ribosomal protein S15 YP_006777351.1 634105 D 1133852 CDS YP_006777352.1 407480203 13700299 634621..636756 1 NC_018658.1 COG1185 Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase); polynucleotide phosphorylase/polyadenylase 636756 13700299 O3K_03110 Escherichia coli O104:H4 str. 2011C-3493 polynucleotide phosphorylase/polyadenylase YP_006777352.1 634621 D 1133852 CDS YP_006777353.1 407480204 13700300 636865..637749 1 NC_018658.1 COG4785 Lipoprotein NlpI, contains TPR repeats; lipoprotein NlpI 637749 13700300 O3K_03115 Escherichia coli O104:H4 str. 2011C-3493 lipoprotein NlpI YP_006777353.1 636865 D 1133852 CDS YP_006777354.1 407480205 13700301 637929..639818 1 NC_018658.1 COG0513 Superfamily II DNA and RNA helicases; ATP-dependent RNA helicase DeaD 639818 13700301 O3K_03120 Escherichia coli O104:H4 str. 2011C-3493 ATP-dependent RNA helicase DeaD YP_006777354.1 637929 D 1133852 CDS YP_006777355.1 407480206 13700302 complement(639819..639956) 1 NC_018658.1 hypothetical protein 639956 13700302 O3K_03125 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777355.1 639819 R 1133852 CDS YP_006777356.1 407480207 13700303 639972..641216 1 NC_018658.1 COG0814 Amino acid permeases; tryptophan permease 641216 13700303 O3K_03130 Escherichia coli O104:H4 str. 2011C-3493 tryptophan permease YP_006777356.1 639972 D 1133852 CDS YP_006777357.1 407480208 13700304 complement(641334..642341) 1 NC_018658.1 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases; hypothetical protein 642341 13700304 O3K_03135 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777357.1 641334 R 1133852 CDS YP_006777358.1 407480209 13700305 complement(642547..643425) 1 NC_018658.1 COG0826 Collagenase and related proteases; protease 643425 13700305 O3K_03140 Escherichia coli O104:H4 str. 2011C-3493 protease YP_006777358.1 642547 R 1133852 CDS YP_006777359.1 407480210 13700306 complement(643434..644429) 1 NC_018658.1 COG0826 Collagenase and related proteases; peptidase, U32 family protein 644429 13700306 O3K_03145 Escherichia coli O104:H4 str. 2011C-3493 peptidase, U32 family protein YP_006777359.1 643434 R 1133852 CDS YP_006777360.1 407480211 13700307 644638..645162 1 NC_018658.1 COG3154 Putative lipid carrier protein; lipid carrier protein 645162 13700307 O3K_03150 Escherichia coli O104:H4 str. 2011C-3493 lipid carrier protein YP_006777360.1 644638 D 1133852 CDS YP_006777361.1 407480212 13700308 645156..645659 1 NC_018658.1 COG3153 Predicted acetyltransferase; hypothetical protein 645659 13700308 O3K_03155 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777361.1 645156 D 1133852 CDS YP_006777362.1 407480213 13700309 complement(645646..645948) 1 NC_018658.1 COG2827 Predicted endonuclease containing a URI domain; GIY-YIG nuclease superfamily protein 645948 13700309 O3K_03160 Escherichia coli O104:H4 str. 2011C-3493 GIY-YIG nuclease superfamily protein YP_006777362.1 645646 R 1133852 CDS YP_006777363.1 407480214 13700310 645999..646442 1 NC_018658.1 COG3787 Uncharacterized protein conserved in bacteria; hypothetical protein 646442 13700310 O3K_03165 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777363.1 645999 D 1133852 CDS YP_006777364.1 407480215 13700311 complement(646422..646940) 1 NC_018658.1 COG0693 Putative intracellular protease/amidase; hypothetical protein 646940 13700311 O3K_03170 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777364.1 646422 R 1133852 CDS YP_006777365.1 407480216 13700312 647068..647703 1 NC_018658.1 COG0702 Predicted nucleoside-diphosphate-sugar epimerases; nucleoside-diphosphate-sugar epimerase 647703 13700312 O3K_03175 Escherichia coli O104:H4 str. 2011C-3493 nucleoside-diphosphate-sugar epimerase YP_006777365.1 647068 D 1133852 CDS YP_006777366.1 407480217 13700313 647776..648816 1 NC_018658.1 COG0701 Predicted permeases; permease 648816 13700313 O3K_03180 Escherichia coli O104:H4 str. 2011C-3493 permease YP_006777366.1 647776 D 1133852 CDS YP_006777367.1 407480218 13700314 complement(648930..649505) 1 NC_018658.1 COG2823 Predicted periplasmic or secreted lipoprotein; outer membrane lipoprotein 649505 13700314 O3K_03185 Escherichia coli O104:H4 str. 2011C-3493 outer membrane lipoprotein YP_006777367.1 648930 R 1133852 CDS YP_006777368.1 407480219 13700315 complement(649515..650105) 1 NC_018658.1 COG0279 Phosphoheptose isomerase; DnaA initiator-associating protein DiaA 650105 13700315 O3K_03190 Escherichia coli O104:H4 str. 2011C-3493 DnaA initiator-associating protein DiaA YP_006777368.1 649515 R 1133852 CDS YP_006777369.1 407480220 13700316 complement(650125..650520) 1 NC_018658.1 COG0792 Predicted endonuclease distantly related to archaeal Holliday junction resolvase; hypothetical protein 650520 13700316 O3K_03195 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777369.1 650125 R 1133852 CDS YP_006777370.1 407480221 13700317 complement(650478..652514) 1 NC_018658.1 COG3107 Putative lipoprotein; LppC family lipoprotein 652514 13700317 O3K_03200 Escherichia coli O104:H4 str. 2011C-3493 LppC family lipoprotein YP_006777370.1 650478 R 1133852 CDS YP_006777371.1 407480222 13700318 652578..653438 1 NC_018658.1 COG0313 Predicted methyltransferases; SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase 653438 13700318 O3K_03205 Escherichia coli O104:H4 str. 2011C-3493 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase YP_006777371.1 652578 D 1133852 CDS YP_006777372.1 407480223 13700319 complement(653481..654572) 1 NC_018658.1 COG3539 P pilus assembly protein, pilin FimA; putative fimbrial protein 654572 13700319 O3K_03210 Escherichia coli O104:H4 str. 2011C-3493 putative fimbrial protein YP_006777372.1 653481 R 1133852 CDS YP_006777373.1 407480224 13700320 complement(654583..657099) 1 NC_018658.1 COG3188 P pilus assembly protein, porin PapC; outer membrane protein 657099 13700320 O3K_03215 Escherichia coli O104:H4 str. 2011C-3493 outer membrane protein YP_006777373.1 654583 R 1133852 CDS YP_006777374.1 407480225 13700321 complement(657129..657824) 1 NC_018658.1 COG3121 P pilus assembly protein, chaperone PapD; putative periplasmic pilin chaperone 657824 13700321 O3K_03220 Escherichia coli O104:H4 str. 2011C-3493 putative periplasmic pilin chaperone YP_006777374.1 657129 R 1133852 CDS YP_006777375.1 407480226 13700322 complement(657904..658488) 1 NC_018658.1 COG3539 P pilus assembly protein, pilin FimA; putative fimbrial-like adhesin protein 658488 13700322 O3K_03225 Escherichia coli O104:H4 str. 2011C-3493 putative fimbrial-like adhesin protein YP_006777375.1 657904 R 1133852 CDS YP_006777376.1 407480227 13700323 complement(658888..659643) 1 NC_018658.1 COG0363 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase; galactosamine-6-phosphate isomerase 659643 13700323 O3K_03230 Escherichia coli O104:H4 str. 2011C-3493 galactosamine-6-phosphate isomerase YP_006777376.1 658888 R 1133852 CDS YP_006777377.1 407480228 13700324 complement(659644..660435) 1 NC_018658.1 COG3716 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID; PTS system N-acetylgalactosamine-specific transporter subunit IID 660435 13700324 O3K_03235 Escherichia coli O104:H4 str. 2011C-3493 PTS system N-acetylgalactosamine-specific transporter subunit IID YP_006777377.1 659644 R 1133852 CDS YP_006777378.1 407480229 13700325 complement(660425..661228) 1 NC_018658.1 COG3715 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC; PTS system N-acetylgalactosamine-specific transporter subunit IIC 661228 13700325 O3K_03240 Escherichia coli O104:H4 str. 2011C-3493 PTS system N-acetylgalactosamine-specific transporter subunit IIC YP_006777378.1 660425 R 1133852 CDS YP_006777379.1 407480230 13700326 complement(661267..661743) 1 NC_018658.1 COG3444 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB; PTS system N-acetylgalactosamine-specific transporter subunit IIB 661743 13700326 O3K_03245 Escherichia coli O104:H4 str. 2011C-3493 PTS system N-acetylgalactosamine-specific transporter subunit IIB YP_006777379.1 661267 R 1133852 CDS YP_006777380.1 407480231 13700327 complement(661910..662770) 1 NC_018658.1 COG0191 Fructose/tagatose bisphosphate aldolase; tagatose-bisphosphate aldolase 662770 kbaY 13700327 kbaY Escherichia coli O104:H4 str. 2011C-3493 tagatose-bisphosphate aldolase YP_006777380.1 661910 R 1133852 CDS YP_006777381.1 407480232 13700328 complement(662783..663937) 1 NC_018658.1 COG2222 Predicted phosphosugar isomerases; tagatose-6-phosphate ketose/aldose isomerase 663937 13700328 O3K_03255 Escherichia coli O104:H4 str. 2011C-3493 tagatose-6-phosphate ketose/aldose isomerase YP_006777381.1 662783 R 1133852 CDS YP_006777382.1 407480233 13700329 complement(664287..665420) 1 NC_018658.1 COG1820 N-acetylglucosamine-6-phosphate deacetylase; N-acetylglucosamine-6-phosphate deacetylase 665420 13700329 O3K_03260 Escherichia coli O104:H4 str. 2011C-3493 N-acetylglucosamine-6-phosphate deacetylase YP_006777382.1 664287 R 1133852 CDS YP_006777383.1 407480234 13700330 complement(665417..665851) 1 NC_018658.1 COG2893 Phosphotransferase system, mannose/fructose-specific component IIA; PTS system transporter subunit IIA 665851 13700330 O3K_03265 Escherichia coli O104:H4 str. 2011C-3493 PTS system transporter subunit IIA YP_006777383.1 665417 R 1133852 CDS YP_006777384.1 407480235 13700331 complement(665869..666747) 1 NC_018658.1 COG3716 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID; PTS system hexose/hexosamine family transporter permease IID 666747 13700331 O3K_03270 Escherichia coli O104:H4 str. 2011C-3493 PTS system hexose/hexosamine family transporter permease IID YP_006777384.1 665869 R 1133852 CDS YP_006777385.1 407480236 13700332 complement(666737..667516) 1 NC_018658.1 COG3715 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC; PTS system N-acetylgalactosamine-specific transporter subunit IIC 667516 13700332 O3K_03275 Escherichia coli O104:H4 str. 2011C-3493 PTS system N-acetylgalactosamine-specific transporter subunit IIC YP_006777385.1 666737 R 1133852 CDS YP_006777386.1 407480237 13700333 complement(667527..668000) 1 NC_018658.1 COG3444 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB; PTS system N-acetylgalactosamine-specific transporter subunit IIB 668000 13700333 O3K_03280 Escherichia coli O104:H4 str. 2011C-3493 PTS system N-acetylgalactosamine-specific transporter subunit IIB YP_006777386.1 667527 R 1133852 CDS YP_006777387.1 407480238 13700334 complement(668023..669303) 1 NC_018658.1 COG4573 Predicted tagatose 6-phosphate kinase; tagatose 6-phosphate aldolase subunit KbaZ 669303 13700334 O3K_03285 Escherichia coli O104:H4 str. 2011C-3493 tagatose 6-phosphate aldolase subunit KbaZ YP_006777387.1 668023 R 1133852 CDS YP_006777388.1 407480239 13700335 669552..670361 1 NC_018658.1 COG1349 Transcriptional regulators of sugar metabolism; DNA-binding transcriptional regulator AgaR 670361 13700335 O3K_03290 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator AgaR YP_006777388.1 669552 D 1133852 CDS YP_006777389.1 407480240 13700336 complement(670416..670880) 1 NC_018658.1 hypothetical protein 670880 13700336 O3K_03295 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777389.1 670416 R 1133852 CDS YP_006777390.1 407480241 13700337 complement(670880..671215) 1 NC_018658.1 COG2002 Regulators of stationary/sporulation gene expression; putative regulator PrlF 671215 13700337 O3K_03300 Escherichia coli O104:H4 str. 2011C-3493 putative regulator PrlF YP_006777390.1 670880 R 1133852 CDS YP_006777391.1 407480242 13700338 complement(671364..672935) 1 NC_018658.1 COG2721 Altronate dehydratase; galactarate dehydratase 672935 13700338 O3K_03305 Escherichia coli O104:H4 str. 2011C-3493 galactarate dehydratase YP_006777391.1 671364 R 1133852 CDS YP_006777392.1 407480243 13700339 673309..674643 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; galactarate transporter 674643 13700339 O3K_03310 Escherichia coli O104:H4 str. 2011C-3493 galactarate transporter YP_006777392.1 673309 D 1133852 CDS YP_006777393.1 407480244 13700340 674659..675429 1 NC_018658.1 COG3836 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; alpha-dehydro-beta-deoxy-D-glucarate aldolase 675429 13700340 O3K_03315 Escherichia coli O104:H4 str. 2011C-3493 alpha-dehydro-beta-deoxy-D-glucarate aldolase YP_006777393.1 674659 D 1133852 CDS YP_006777394.1 407480245 13700341 675459..676349 1 NC_018658.1 COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases; tartronate semialdehyde reductase 676349 garR 13700341 garR Escherichia coli O104:H4 str. 2011C-3493 tartronate semialdehyde reductase YP_006777394.1 675459 D 1133852 CDS YP_006777395.1 407480246 13700342 676446..677591 1 NC_018658.1 COG1929 Glycerate kinase; glycerate kinase 677591 13700342 O3K_03325 Escherichia coli O104:H4 str. 2011C-3493 glycerate kinase YP_006777395.1 676446 D 1133852 CDS YP_006777396.1 407480247 13700343 complement(678462..679442) 1 NC_018658.1 COG3547 Transposase and inactivated derivatives; IS621 transposase 679442 13700343 O3K_03330 Escherichia coli O104:H4 str. 2011C-3493 IS621 transposase YP_006777396.1 678462 R 1133852 CDS YP_006777397.1 407480248 13700344 complement(679780..680967) 1 NC_018658.1 hypothetical protein 680967 13700344 O3K_03335 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777397.1 679780 R 1133852 CDS YP_006777398.1 407480249 13700345 complement(680989..681528) 1 NC_018658.1 COG0443 Molecular chaperone; hypothetical protein 681528 13700345 O3K_03340 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777398.1 680989 R 1133852 CDS YP_006777399.1 407480250 13700346 complement(681784..682140) 1 NC_018658.1 DNA-binding transcriptional activator TdcR 682140 13700346 O3K_03345 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional activator TdcR YP_006777399.1 681784 R 1133852 CDS YP_006777400.1 407480251 13700347 682317..683255 1 NC_018658.1 COG0583 Transcriptional regulator; DNA-binding transcriptional activator TdcA 683255 13700347 O3K_03350 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional activator TdcA YP_006777400.1 682317 D 1133852 CDS YP_006777401.1 407480252 13700348 683354..684343 1 NC_018658.1 COG1171 Threonine dehydratase; threonine dehydratase 684343 13700348 O3K_03355 Escherichia coli O104:H4 str. 2011C-3493 threonine dehydratase YP_006777401.1 683354 D 1133852 CDS YP_006777402.1 407480253 13700349 684365..685696 1 NC_018658.1 COG0814 Amino acid permeases; threonine/serine transporter TdcC 685696 13700349 O3K_03360 Escherichia coli O104:H4 str. 2011C-3493 threonine/serine transporter TdcC YP_006777402.1 684365 D 1133852 CDS YP_006777403.1 407480254 13700350 685722..686930 1 NC_018658.1 COG0282 Acetate kinase; propionate/acetate kinase 686930 13700350 O3K_03365 Escherichia coli O104:H4 str. 2011C-3493 propionate/acetate kinase YP_006777403.1 685722 D 1133852 CDS YP_006777404.1 407480255 13700351 686964..689258 1 NC_018658.1 COG1882 Pyruvate-formate lyase; Keto-acid formate acetyltransferase 689258 13700351 O3K_03370 Escherichia coli O104:H4 str. 2011C-3493 Keto-acid formate acetyltransferase YP_006777404.1 686964 D 1133852 CDS YP_006777405.1 407480256 13700352 689272..689661 1 NC_018658.1 COG0251 Putative translation initiation inhibitor, yjgF family; putative endoribonuclease L-PSP 689661 13700352 O3K_03375 Escherichia coli O104:H4 str. 2011C-3493 putative endoribonuclease L-PSP YP_006777405.1 689272 D 1133852 CDS YP_006777406.1 407480257 13700353 689733..691097 1 NC_018658.1 COG1760 L-serine deaminase; L-serine dehydratase TdcG 691097 13700353 O3K_03380 Escherichia coli O104:H4 str. 2011C-3493 L-serine dehydratase TdcG YP_006777406.1 689733 D 1133852 CDS YP_006777407.1 407480258 13700354 691372..692703 1 NC_018658.1 COG0814 Amino acid permeases; transporter 692703 13700354 O3K_03385 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006777407.1 691372 D 1133852 CDS YP_006777408.1 407480259 13700355 692731..694041 1 NC_018658.1 COG3681 Uncharacterized conserved protein; hypothetical protein 694041 13700355 O3K_03390 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777408.1 692731 D 1133852 CDS YP_006777409.1 407480260 13700356 complement(694102..694266) 1 NC_018658.1 hypothetical protein 694266 13700356 O3K_03395 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777409.1 694102 R 1133852 CDS YP_006777410.1 407480261 13700357 complement(694289..694990) 1 NC_018658.1 COG1741 Pirin-related protein; putative pirin-related protein 694990 13700357 O3K_03400 Escherichia coli O104:H4 str. 2011C-3493 putative pirin-related protein YP_006777410.1 694289 R 1133852 CDS YP_006777411.1 407480262 13700358 695095..695991 1 NC_018658.1 COG0583 Transcriptional regulator; LysR family transcriptional regulator 695991 13700358 O3K_03405 Escherichia coli O104:H4 str. 2011C-3493 LysR family transcriptional regulator YP_006777411.1 695095 D 1133852 CDS YP_006777412.1 407480263 13700359 complement(696035..696538) 1 NC_018658.1 COG1662 Transposase and inactivated derivatives, IS1 family; IS1 transposase InsAB' 696538 13700359 O3K_03410 Escherichia coli O104:H4 str. 2011C-3493 IS1 transposase InsAB' YP_006777412.1 696035 R 1133852 CDS YP_006777413.1 407480264 13700360 complement(696457..696681) 1 NC_018658.1 COG3677 Transposase and inactivated derivatives; IS1 repressor A 696681 13700360 O3K_03415 Escherichia coli O104:H4 str. 2011C-3493 IS1 repressor A YP_006777413.1 696457 R 1133852 CDS YP_006777414.1 407480265 13700361 complement(696842..697207) 1 NC_018658.1 COG3152 Predicted membrane protein; hypothetical protein 697207 13700361 O3K_03420 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777414.1 696842 R 1133852 CDS YP_006777415.1 407480266 13700362 complement(697500..698486) 1 NC_018658.1 COG0435 Predicted glutathione S-transferase; putative transferase 698486 13700362 O3K_03425 Escherichia coli O104:H4 str. 2011C-3493 putative transferase YP_006777415.1 697500 R 1133852 CDS YP_006777416.1 407480267 13700363 complement(698556..698948) 1 NC_018658.1 COG2259 Predicted membrane protein; hypothetical protein 698948 13700363 O3K_03430 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777416.1 698556 R 1133852 CDS YP_006777417.1 407480268 13700364 complement(699134..699433) 1 NC_018658.1 hypothetical protein 699433 13700364 O3K_03435 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777417.1 699134 R 1133852 CDS YP_006777418.1 407480269 13700365 complement(699423..699827) 1 NC_018658.1 hypothetical protein 699827 13700365 O3K_03440 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777418.1 699423 R 1133852 CDS YP_006777419.1 407480270 13700366 complement(699830..700135) 1 NC_018658.1 COG4575 Uncharacterized conserved protein; hypothetical protein 700135 13700366 O3K_03445 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777419.1 699830 R 1133852 CDS YP_006777420.1 407480271 13700367 complement(700173..700541) 1 NC_018658.1 hypothetical protein 700541 13700367 O3K_03450 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777420.1 700173 R 1133852 CDS YP_006777421.1 407480272 13700368 complement(700688..701071) 1 NC_018658.1 EnvZ/OmpR regulon moderator 701071 13700368 O3K_03455 Escherichia coli O104:H4 str. 2011C-3493 EnvZ/OmpR regulon moderator YP_006777421.1 700688 R 1133852 CDS YP_006777422.1 407480273 13700369 complement(701075..701737) 1 NC_018658.1 COG0586 Uncharacterized membrane-associated protein; hypothetical protein 701737 13700369 O3K_03460 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777422.1 701075 R 1133852 CDS YP_006777423.1 407480274 13700370 complement(702082..702858) 1 NC_018658.1 COG2186 Transcriptional regulators; DNA-binding transcriptional repressor ExuR 702858 13700370 O3K_03465 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional repressor ExuR YP_006777423.1 702082 R 1133852 CDS YP_006777424.1 407480275 13700371 703154..703870 1 NC_018658.1 putative fimbrial protein 703870 13700371 O3K_03470 Escherichia coli O104:H4 str. 2011C-3493 putative fimbrial protein YP_006777424.1 703154 D 1133852 CDS YP_006777425.1 407480276 13700372 703900..704400 1 NC_018658.1 putative fimbrial subunit 704400 13700372 O3K_03475 Escherichia coli O104:H4 str. 2011C-3493 putative fimbrial subunit YP_006777425.1 703900 D 1133852 CDS YP_006777426.1 407480277 13700373 704474..707176 1 NC_018658.1 hypothetical protein 707176 13700373 O3K_03480 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777426.1 704474 D 1133852 CDS YP_006777427.1 407480278 13700374 707173..708261 1 NC_018658.1 hypothetical protein 708261 13700374 O3K_03485 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777427.1 707173 D 1133852 CDS YP_006777428.1 407480279 13700375 complement(708349..709647) 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; hexuronate transporter 709647 13700375 O3K_03490 Escherichia coli O104:H4 str. 2011C-3493 hexuronate transporter YP_006777428.1 708349 R 1133852 CDS YP_006777429.1 407480280 13700376 710130..711542 1 NC_018658.1 COG1904 Glucuronate isomerase; glucuronate isomerase 711542 13700376 O3K_03495 Escherichia coli O104:H4 str. 2011C-3493 glucuronate isomerase YP_006777429.1 710130 D 1133852 CDS YP_006777430.1 407480281 13700377 711557..713044 1 NC_018658.1 COG2721 Altronate dehydratase; altronate hydrolase 713044 13700377 O3K_03500 Escherichia coli O104:H4 str. 2011C-3493 altronate hydrolase YP_006777430.1 711557 D 1133852 CDS YP_006777431.1 407480282 13700378 713127..713678 1 NC_018658.1 inner membrane protein 713678 13700378 O3K_03505 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006777431.1 713127 D 1133852 CDS YP_006777432.1 407480283 13700379 complement(713683..714927) 1 NC_018658.1 COG3633 Na+/serine symporter; serine/threonine transporter SstT 714927 13700379 O3K_03510 Escherichia coli O104:H4 str. 2011C-3493 serine/threonine transporter SstT YP_006777432.1 713683 R 1133852 CDS YP_006777433.1 407480284 13700380 complement(715326..716291) 1 NC_018658.1 COG0861 Membrane protein TerC, possibly involved in tellurium resistance; inner membrane protein 716291 13700380 O3K_03515 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006777433.1 715326 R 1133852 CDS YP_006777434.1 407480285 13700381 complement(716574..717560) 1 NC_018658.1 COG0673 Predicted dehydrogenases and related proteins; NAD(P)-binding dehydrogenase 717560 13700381 O3K_03520 Escherichia coli O104:H4 str. 2011C-3493 NAD(P)-binding dehydrogenase YP_006777434.1 716574 R 1133852 CDS YP_006777435.1 407480286 13700382 complement(717639..718322) 1 NC_018658.1 COG2949 Uncharacterized membrane protein; thioredoxin-like protein 718322 13700382 O3K_03525 Escherichia coli O104:H4 str. 2011C-3493 thioredoxin-like protein YP_006777435.1 717639 R 1133852 CDS YP_006777436.1 407480287 13700383 complement(718399..718902) 1 NC_018658.1 COG1451 Predicted metal-dependent hydrolase; hypothetical protein 718902 13700383 O3K_03530 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777436.1 718399 R 1133852 CDS YP_006777437.1 407480288 13700384 718987..720123 1 NC_018658.1 COG2813 16S RNA G1207 methylase RsmC; SAM-dependent 23S ribosomal RNA mG1835 methyltransferase 720123 13700384 O3K_03535 Escherichia coli O104:H4 str. 2011C-3493 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase YP_006777437.1 718987 D 1133852 CDS YP_006777438.1 407480289 13700385 720227..720397 1 NC_018658.1 hypothetical protein 720397 13700385 O3K_03540 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777438.1 720227 D 1133852 CDS YP_006777439.1 407480290 13700386 720394..720810 1 NC_018658.1 COG5499 Predicted transcription regulator containing HTH domain; putative DNA-binding transcriptional regulator 720810 13700386 O3K_03545 Escherichia coli O104:H4 str. 2011C-3493 putative DNA-binding transcriptional regulator YP_006777439.1 720394 D 1133852 CDS YP_006777440.1 407480291 13700387 complement(720855..722873) 1 NC_018658.1 COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family; 2,4-dienoyl-CoA reductase 722873 13700387 O3K_03550 Escherichia coli O104:H4 str. 2011C-3493 2,4-dienoyl-CoA reductase YP_006777440.1 720855 R 1133852 CDS YP_006777441.1 407480292 13700388 complement(723199..725550) 1 NC_018658.1 COG0403 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain; alpha-glucosidase 725550 13700388 O3K_03555 Escherichia coli O104:H4 str. 2011C-3493 alpha-glucosidase YP_006777441.1 723199 R 1133852 CDS YP_006777442.1 407480293 13700389 complement(725567..726637) 1 NC_018658.1 hypothetical protein 726637 13700389 O3K_03560 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777442.1 725567 R 1133852 CDS YP_006777443.1 407480294 13700390 complement(726771..728204) 1 NC_018658.1 COG0531 Amino acid transporters; transporter 728204 13700390 O3K_03565 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006777443.1 726771 R 1133852 CDS YP_006777444.1 407480295 13700391 complement(728267..728716) 1 NC_018658.1 COG2731 Beta-galactosidase, beta subunit; cryptic beta-D-galactosidase subunit beta 728716 ebgC 13700391 ebgC Escherichia coli O104:H4 str. 2011C-3493 cryptic beta-D-galactosidase subunit beta YP_006777444.1 728267 R 1133852 CDS YP_006777445.1 407480296 13700392 complement(728713..731805) 1 NC_018658.1 COG3250 Beta-galactosidase/beta-glucuronidase; cryptic beta-D-galactosidase subunit alpha 731805 ebgA 13700392 ebgA Escherichia coli O104:H4 str. 2011C-3493 cryptic beta-D-galactosidase subunit alpha YP_006777445.1 728713 R 1133852 CDS YP_006777446.1 407480297 13700393 complement(731989..732972) 1 NC_018658.1 COG1609 Transcriptional regulators; DNA-binding transcriptional repressor EbgR 732972 13700393 O3K_03580 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional repressor EbgR YP_006777446.1 731989 R 1133852 CDS YP_006777447.1 407480298 13700394 733191..733523 1 NC_018658.1 COG0073 EMAP domain; tRNA-binding protein 733523 13700394 O3K_03585 Escherichia coli O104:H4 str. 2011C-3493 tRNA-binding protein YP_006777447.1 733191 D 1133852 CDS YP_006777448.1 407480299 13700395 complement(733565..734971) 1 NC_018658.1 COG4992 Ornithine/acetylornithine aminotransferase; putrescine--2-oxoglutarate aminotransferase 734971 13700395 O3K_03590 Escherichia coli O104:H4 str. 2011C-3493 putrescine--2-oxoglutarate aminotransferase YP_006777448.1 733565 R 1133852 CDS YP_006777449.1 407480300 13700396 735362..736882 1 NC_018658.1 COG2202 FOG: PAS/PAC domain; signal transducer for aerotaxis/methyl accepting chemotaxis protein 736882 13700396 O3K_03595 Escherichia coli O104:H4 str. 2011C-3493 signal transducer for aerotaxis/methyl accepting chemotaxis protein YP_006777449.1 735362 D 1133852 CDS YP_006777450.1 407480301 13700397 complement(737036..737659) 1 NC_018658.1 COG1695 Predicted transcriptional regulators; transcriptional regulator 737659 13700397 O3K_03600 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator YP_006777450.1 737036 R 1133852 CDS YP_006777451.1 407480302 13700398 737936..738700 1 NC_018658.1 COG2375 Siderophore-interacting protein; siderophore-interacting protein 738700 13700398 O3K_03605 Escherichia coli O104:H4 str. 2011C-3493 siderophore-interacting protein YP_006777451.1 737936 D 1133852 CDS YP_006777452.1 407480303 13700400 738954..739460 1 NC_018658.1 COG3663 G:T/U mismatch-specific DNA glycosylase; G/U mismatch-specific DNA glycosylase 739460 13700400 O3K_03610 Escherichia coli O104:H4 str. 2011C-3493 G/U mismatch-specific DNA glycosylase YP_006777452.1 738954 D 1133852 CDS YP_006777453.1 407480304 13700401 complement(739538..741379) 1 NC_018658.1 COG0568 DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32); RNA polymerase sigma factor RpoD 741379 13700401 O3K_03615 Escherichia coli O104:H4 str. 2011C-3493 RNA polymerase sigma factor RpoD YP_006777453.1 739538 R 1133852 CDS YP_006777454.1 407480305 13700402 complement(741574..743319) 1 NC_018658.1 COG0358 DNA primase (bacterial type); DNA primase 743319 dnaG 13700402 dnaG Escherichia coli O104:H4 str. 2011C-3493 DNA primase YP_006777454.1 741574 R 1133852 CDS YP_006777455.1 407480306 13700403 complement(743430..743645) 1 NC_018658.1 COG0828 Ribosomal protein S21; 30S ribosomal protein S21 743645 rpsU 13700403 rpsU Escherichia coli O104:H4 str. 2011C-3493 30S ribosomal protein S21 YP_006777455.1 743430 R 1133852 CDS YP_006777456.1 407480307 13700404 743882..744895 1 NC_018658.1 COG0533 Metal-dependent proteases with possible chaperone activity; UGMP family protein 744895 13700404 O3K_03630 Escherichia coli O104:H4 str. 2011C-3493 UGMP family protein YP_006777456.1 743882 D 1133852 CDS YP_006777457.1 407480308 13700405 complement(744938..746401) 1 NC_018658.1 COG0471 Di- and tricarboxylate transporters; tartrate:succinate antiporter 746401 13700405 O3K_03635 Escherichia coli O104:H4 str. 2011C-3493 tartrate:succinate antiporter YP_006777457.1 744938 R 1133852 CDS YP_006777458.1 407480309 13700406 complement(746450..747055) 1 NC_018658.1 COG1838 Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain; L(+)-tartrate dehydratase subunit beta 747055 13700406 O3K_03640 Escherichia coli O104:H4 str. 2011C-3493 L(+)-tartrate dehydratase subunit beta YP_006777458.1 746450 R 1133852 CDS YP_006777459.1 407480310 13700407 complement(747052..747963) 1 NC_018658.1 COG1951 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain; tartrate dehydratase subunit alpha 747963 13700407 O3K_03645 Escherichia coli O104:H4 str. 2011C-3493 tartrate dehydratase subunit alpha YP_006777459.1 747052 R 1133852 CDS YP_006777460.1 407480311 13700408 748170..749102 1 NC_018658.1 COG0583 Transcriptional regulator; transcriptional activator TtdR 749102 13700408 O3K_03650 Escherichia coli O104:H4 str. 2011C-3493 transcriptional activator TtdR YP_006777460.1 748170 D 1133852 CDS YP_006777461.1 407480312 13700409 complement(749115..749732) 1 NC_018658.1 COG0344 Predicted membrane protein; putative glycerol-3-phosphate acyltransferase PlsY 749732 13700409 O3K_03655 Escherichia coli O104:H4 str. 2011C-3493 putative glycerol-3-phosphate acyltransferase PlsY YP_006777461.1 749115 R 1133852 CDS YP_006777462.1 407480313 13700410 749837..750205 1 NC_018658.1 COG1539 Dihydroneopterin aldolase; bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase 750205 folB 13700410 folB Escherichia coli O104:H4 str. 2011C-3493 bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase YP_006777462.1 749837 D 1133852 CDS YP_006777463.1 407480314 13700411 750296..751117 1 NC_018658.1 COG1968 Uncharacterized bacitracin resistance protein; undecaprenyl pyrophosphate phosphatase 751117 13700411 O3K_03665 Escherichia coli O104:H4 str. 2011C-3493 undecaprenyl pyrophosphate phosphatase YP_006777463.1 750296 D 1133852 CDS YP_006777464.1 407480315 13700412 complement(751280..752518) 1 NC_018658.1 COG0617 tRNA nucleotidyltransferase/poly(A) polymerase; multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase 752518 cca 13700412 cca Escherichia coli O104:H4 str. 2011C-3493 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase YP_006777464.1 751280 R 1133852 CDS YP_006777465.1 407480316 13700413 complement(752582..753202) 1 NC_018658.1 COG3103 SH3 domain protein; SH3 domain-containing protein 753202 13700413 O3K_03675 Escherichia coli O104:H4 str. 2011C-3493 SH3 domain-containing protein YP_006777465.1 752582 R 1133852 CDS YP_006777466.1 407480317 13700414 753444..754745 1 NC_018658.1 COG3025 Uncharacterized conserved protein; adenylate cyclase 754745 13700414 O3K_03680 Escherichia coli O104:H4 str. 2011C-3493 adenylate cyclase YP_006777466.1 753444 D 1133852 CDS YP_006777467.1 407480318 13700415 754768..757608 1 NC_018658.1 COG1391 Glutamine synthetase adenylyltransferase; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase 757608 13700415 O3K_03685 Escherichia coli O104:H4 str. 2011C-3493 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase YP_006777467.1 754768 D 1133852 CDS YP_006777468.1 407480319 13700416 757656..759089 1 NC_018658.1 COG2870 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase; bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase 759089 13700416 O3K_03690 Escherichia coli O104:H4 str. 2011C-3493 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase YP_006777468.1 757656 D 1133852 CDS YP_006777469.1 407480320 13700417 complement(759532..759783) 1 NC_018658.1 hypothetical protein 759783 13700417 O3K_03695 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777469.1 759532 R 1133852 CDS YP_006777470.1 407480321 13700418 complement(759883..761544) 1 NC_018658.1 COG2268 Uncharacterized protein conserved in bacteria; hypothetical protein 761544 13700418 O3K_03700 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777470.1 759883 R 1133852 CDS YP_006777471.1 407480322 13700419 complement(761571..762200) 1 NC_018658.1 inner membrane protein 762200 13700419 O3K_03705 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006777471.1 761571 R 1133852 CDS YP_006777472.1 407480323 13700420 762469..762669 1 NC_018658.1 glycogen synthesis protein GlgS 762669 13700420 O3K_03710 Escherichia coli O104:H4 str. 2011C-3493 glycogen synthesis protein GlgS YP_006777472.1 762469 D 1133852 CDS YP_006777473.1 407480324 13700421 complement(762712..763776) 1 NC_018658.1 hypothetical protein 763776 13700421 O3K_03715 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777473.1 762712 R 1133852 CDS YP_006777474.1 407480325 13700422 complement(763778..764527) 1 NC_018658.1 COG3121 P pilus assembly protein, chaperone PapD; periplasmic pilin chaperone 764527 13700422 O3K_03720 Escherichia coli O104:H4 str. 2011C-3493 periplasmic pilin chaperone YP_006777474.1 763778 R 1133852 CDS YP_006777475.1 407480326 13700423 complement(764543..767047) 1 NC_018658.1 COG3188 P pilus assembly protein, porin PapC; putative outer membrane usher protein 767047 13700423 O3K_03725 Escherichia coli O104:H4 str. 2011C-3493 putative outer membrane usher protein YP_006777475.1 764543 R 1133852 CDS YP_006777476.1 407480327 13700424 complement(767107..767658) 1 NC_018658.1 COG3539 P pilus assembly protein, pilin FimA; putative fimbrial protein 767658 13700424 O3K_03730 Escherichia coli O104:H4 str. 2011C-3493 putative fimbrial protein YP_006777476.1 767107 R 1133852 CDS YP_006777477.1 407480328 13700425 complement(767941..768231) 1 NC_018658.1 COG2960 Uncharacterized protein conserved in bacteria; hypothetical protein 768231 13700425 O3K_03735 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777477.1 767941 R 1133852 CDS YP_006777478.1 407480329 13700426 768605..769258 1 NC_018658.1 COG0108 3,4-dihydroxy-2-butanone 4-phosphate synthase; 3,4-dihydroxy-2-butanone 4-phosphate synthase 769258 ribB 13700426 ribB Escherichia coli O104:H4 str. 2011C-3493 3,4-dihydroxy-2-butanone 4-phosphate synthase YP_006777478.1 768605 D 1133852 CDS YP_006777479.1 407480330 13700427 769519..769689 1 NC_018658.1 hypothetical protein 769689 13700427 O3K_03745 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777479.1 769519 D 1133852 CDS YP_006777480.1 407480331 13700428 complement(769747..770520) 1 NC_018658.1 COG0428 Predicted divalent heavy-metal cations transporter; zinc transporter ZupT 770520 13700428 O3K_03750 Escherichia coli O104:H4 str. 2011C-3493 zinc transporter ZupT YP_006777480.1 769747 R 1133852 CDS YP_006777481.1 407480332 13700429 770663..771451 1 NC_018658.1 COG3384 Uncharacterized conserved protein; LigB family dioxygenase 771451 13700429 O3K_03755 Escherichia coli O104:H4 str. 2011C-3493 LigB family dioxygenase YP_006777481.1 770663 D 1133852 CDS YP_006777482.1 407480333 13700430 complement(771489..772649) 1 NC_018658.1 COG0754 Glutathionylspermidine synthase; hypothetical protein 772649 13700430 O3K_03760 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777482.1 771489 R 1133852 CDS YP_006777483.1 407480334 13700431 complement(772655..773326) 1 NC_018658.1 COG5463 Predicted integral membrane protein; hypothetical protein 773326 13700431 O3K_03765 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777483.1 772655 R 1133852 CDS YP_006777484.1 407480335 13700432 complement(773474..774955) 1 NC_018658.1 COG1538 Outer membrane protein; outer membrane channel protein 774955 tolC 13700432 tolC Escherichia coli O104:H4 str. 2011C-3493 outer membrane channel protein YP_006777484.1 773474 R 1133852 CDS YP_006777485.1 407480336 13700433 775160..775789 1 NC_018658.1 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; ADP-ribose pyrophosphatase NudF 775789 nudF 13700433 nudF Escherichia coli O104:H4 str. 2011C-3493 ADP-ribose pyrophosphatase NudF YP_006777485.1 775160 D 1133852 CDS YP_006777486.1 407480337 13700434 775790..776212 1 NC_018658.1 COG3151 Uncharacterized protein conserved in bacteria; putative dehydrogenase 776212 13700434 O3K_03780 Escherichia coli O104:H4 str. 2011C-3493 putative dehydrogenase YP_006777486.1 775790 D 1133852 CDS YP_006777487.1 407480338 13700435 776237..777064 1 NC_018658.1 COG1409 Predicted phosphohydrolases; cyclic 3',5'-adenosine monophosphate phosphodiesterase 777064 13700435 O3K_03785 Escherichia coli O104:H4 str. 2011C-3493 cyclic 3',5'-adenosine monophosphate phosphodiesterase YP_006777487.1 776237 D 1133852 CDS YP_006777488.1 407480339 13700436 777064..777645 1 NC_018658.1 COG3150 Predicted esterase; esterase YqiA 777645 13700436 O3K_03790 Escherichia coli O104:H4 str. 2011C-3493 esterase YqiA YP_006777488.1 777064 D 1133852 CDS YP_006777489.1 407480340 13700437 777674..779566 1 NC_018658.1 COG0187 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit; DNA topoisomerase IV subunit B 779566 13700437 O3K_03795 Escherichia coli O104:H4 str. 2011C-3493 DNA topoisomerase IV subunit B YP_006777489.1 777674 D 1133852 CDS YP_006777490.1 407480341 13700438 complement(779614..779928) 1 NC_018658.1 COG1359 Uncharacterized conserved protein; hypothetical protein 779928 13700438 O3K_03800 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777490.1 779614 R 1133852 CDS YP_006777491.1 407480342 13700439 complement(779959..780540) 1 NC_018658.1 COG2249 Putative NADPH-quinone reductase (modulator of drug activity B); Modulator of drug activity B 780540 13700439 O3K_03805 Escherichia coli O104:H4 str. 2011C-3493 Modulator of drug activity B YP_006777491.1 779959 R 1133852 CDS YP_006777492.1 407480343 13700440 780859..781191 1 NC_018658.1 hypothetical protein 781191 13700440 O3K_03810 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777492.1 780859 D 1133852 CDS YP_006777493.1 407480344 13700441 complement(781237..782586) 1 NC_018658.1 COG0642 Signal transduction histidine kinase; sensor protein QseC 782586 13700441 O3K_03815 Escherichia coli O104:H4 str. 2011C-3493 sensor protein QseC YP_006777493.1 781237 R 1133852 CDS YP_006777494.1 407480345 13700442 complement(782583..783242) 1 NC_018658.1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; DNA-binding transcriptional regulator QseB 783242 13700442 O3K_03820 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator QseB YP_006777494.1 782583 R 1133852 CDS YP_006777495.1 407480346 13700443 783394..783786 1 NC_018658.1 COG3111 Uncharacterized conserved protein; hypothetical protein 783786 13700443 O3K_03825 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777495.1 783394 D 1133852 CDS YP_006777496.1 407480347 13700444 783839..784321 1 NC_018658.1 COG3449 DNA gyrase inhibitor; transcriptional regulator 784321 13700444 O3K_03830 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator YP_006777496.1 783839 D 1133852 CDS YP_006777497.1 407480348 13700445 784867..787125 1 NC_018658.1 COG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit; DNA topoisomerase IV subunit A 787125 13700445 O3K_03835 Escherichia coli O104:H4 str. 2011C-3493 DNA topoisomerase IV subunit A YP_006777497.1 784867 D 1133852 CDS YP_006777498.1 407480349 13700446 787358..788095 1 NC_018658.1 COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase; 1-acyl-sn-glycerol-3-phosphate acyltransferase 788095 13700446 O3K_03840 Escherichia coli O104:H4 str. 2011C-3493 1-acyl-sn-glycerol-3-phosphate acyltransferase YP_006777498.1 787358 D 1133852 CDS YP_006777499.1 407480350 13700447 788170..789582 1 NC_018658.1 COG2132 Putative multicopper oxidases; FtsI repressor 789582 13700447 O3K_03845 Escherichia coli O104:H4 str. 2011C-3493 FtsI repressor YP_006777499.1 788170 D 1133852 CDS YP_006777500.1 407480351 13700448 789693..791912 1 NC_018658.1 COG1032 Fe-S oxidoreductase; hypothetical protein 791912 13700448 O3K_03850 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777500.1 789693 D 1133852 CDS YP_006777501.1 407480352 13700449 complement(791955..792212) 1 NC_018658.1 putative outer membrane lipoprotein 792212 13700449 O3K_03855 Escherichia coli O104:H4 str. 2011C-3493 putative outer membrane lipoprotein YP_006777501.1 791955 R 1133852 CDS YP_006777502.1 407480353 13700450 complement(792263..793189) 1 NC_018658.1 hypothetical protein 793189 13700450 O3K_03860 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777502.1 792263 R 1133852 CDS YP_006777503.1 407480354 13700451 complement(793389..794216) 1 NC_018658.1 COG0656 Aldo/keto reductases, related to diketogulonate reductase; 2,5-diketo-D-gluconate reductase A 794216 dkgA 13700451 dkgA Escherichia coli O104:H4 str. 2011C-3493 2,5-diketo-D-gluconate reductase A YP_006777503.1 793389 R 1133852 CDS YP_006777504.1 407480355 13700452 complement(794321..795484) 1 NC_018658.1 COG1979 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family; aldehyde reductase 795484 13700452 O3K_03870 Escherichia coli O104:H4 str. 2011C-3493 aldehyde reductase YP_006777504.1 794321 R 1133852 CDS YP_006777505.1 407480356 13700453 795535..795681 1 NC_018658.1 hypothetical protein 795681 13700453 O3K_03875 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777505.1 795535 D 1133852 CDS YP_006777506.1 407480357 13700454 795621..796577 1 NC_018658.1 COG2207 AraC-type DNA-binding domain-containing proteins; DNA-binding transcriptional regulator 796577 13700454 O3K_03880 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator YP_006777506.1 795621 D 1133852 CDS YP_006777507.1 407480358 13700455 complement(796617..797276) 1 NC_018658.1 COG0586 Uncharacterized membrane-associated protein; hypothetical protein 797276 13700455 O3K_03885 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777507.1 796617 R 1133852 CDS YP_006777508.1 407480359 13700456 complement(797416..798603) 1 NC_018658.1 COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases; cystathionine beta-lyase 798603 13700456 O3K_03890 Escherichia coli O104:H4 str. 2011C-3493 cystathionine beta-lyase YP_006777508.1 797416 R 1133852 CDS YP_006777509.1 407480360 13700457 798855..799589 1 NC_018658.1 COG0811 Biopolymer transport proteins; biopolymer transport protein ExbB 799589 13700457 O3K_03895 Escherichia coli O104:H4 str. 2011C-3493 biopolymer transport protein ExbB YP_006777509.1 798855 D 1133852 CDS YP_006777510.1 407480361 13700458 799596..800021 1 NC_018658.1 COG0848 Biopolymer transport protein; biopolymer transport protein ExbD 800021 13700458 O3K_03900 Escherichia coli O104:H4 str. 2011C-3493 biopolymer transport protein ExbD YP_006777510.1 799596 D 1133852 CDS YP_006777511.1 407480362 13700459 complement(800060..800944) 1 NC_018658.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); oxidoreductase 800944 13700459 O3K_03905 Escherichia coli O104:H4 str. 2011C-3493 oxidoreductase YP_006777511.1 800060 R 1133852 CDS YP_006777512.1 407480363 13700460 801135..801629 1 NC_018658.1 COG2862 Predicted membrane protein; hypothetical protein 801629 13700460 O3K_03910 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777512.1 801135 D 1133852 CDS YP_006777513.1 407480364 13700461 complement(801669..802709) 1 NC_018658.1 COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases); L-glyceraldehyde 3-phosphate reductase 802709 13700461 O3K_03915 Escherichia coli O104:H4 str. 2011C-3493 L-glyceraldehyde 3-phosphate reductase YP_006777513.1 801669 R 1133852 CDS YP_006777514.1 407480365 13700462 802866..803753 1 NC_018658.1 COG0412 Dienelactone hydrolase and related enzymes; hypothetical protein 803753 13700462 O3K_03920 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777514.1 802866 D 1133852 CDS YP_006777515.1 407480366 13700463 803872..804159 1 NC_018658.1 hypothetical protein 804159 13700463 O3K_03925 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777515.1 803872 D 1133852 CDS YP_006777516.1 407480367 13700464 804348..805466 1 NC_018658.1 COG1740 Ni,Fe-hydrogenase I small subunit; hydrogenase 2 small subunit 805466 13700464 O3K_03930 Escherichia coli O104:H4 str. 2011C-3493 hydrogenase 2 small subunit YP_006777516.1 804348 D 1133852 CDS YP_006777517.1 407480368 13700465 805469..806455 1 NC_018658.1 COG0437 Fe-S-cluster-containing hydrogenase components 1; hydrogenase 2 protein HybA 806455 13700465 O3K_03935 Escherichia coli O104:H4 str. 2011C-3493 hydrogenase 2 protein HybA YP_006777517.1 805469 D 1133852 CDS YP_006777518.1 407480369 13700466 806445..807623 1 NC_018658.1 COG5557 Polysulphide reductase; putative hydrogenase 2 b cytochrome subunit 807623 13700466 O3K_03940 Escherichia coli O104:H4 str. 2011C-3493 putative hydrogenase 2 b cytochrome subunit YP_006777518.1 806445 D 1133852 CDS YP_006777519.1 407480370 13700467 807620..809323 1 NC_018658.1 COG0374 Ni,Fe-hydrogenase I large subunit; hydrogenase 2 large subunit 809323 13700467 O3K_03945 Escherichia coli O104:H4 str. 2011C-3493 hydrogenase 2 large subunit YP_006777519.1 807620 D 1133852 CDS YP_006777520.1 407480371 13700468 809323..809817 1 NC_018658.1 COG0680 Ni,Fe-hydrogenase maturation factor; hydrogenase 2 maturation endopeptidase 809817 hybD 13700468 hybD Escherichia coli O104:H4 str. 2011C-3493 hydrogenase 2 maturation endopeptidase YP_006777520.1 809323 D 1133852 CDS YP_006777521.1 407480372 13700469 809810..810298 1 NC_018658.1 hydrogenase 2-specific chaperone 810298 13700469 O3K_03955 Escherichia coli O104:H4 str. 2011C-3493 hydrogenase 2-specific chaperone YP_006777521.1 809810 D 1133852 CDS YP_006777522.1 407480373 13700470 810291..810632 1 NC_018658.1 COG0375 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression); hydrogenase nickel incorporation protein HybF 810632 13700470 O3K_03960 Escherichia coli O104:H4 str. 2011C-3493 hydrogenase nickel incorporation protein HybF YP_006777522.1 810291 D 1133852 CDS YP_006777523.1 407480374 13700471 810645..810893 1 NC_018658.1 COG0298 Hydrogenase maturation factor; hydrogenase 2 accessory protein HypG 810893 13700471 O3K_03965 Escherichia coli O104:H4 str. 2011C-3493 hydrogenase 2 accessory protein HypG YP_006777523.1 810645 D 1133852 CDS YP_006777524.1 407480375 13700472 complement(811015..811995) 1 NC_018658.1 COG3547 Transposase and inactivated derivatives; IS621 transposase 811995 13700472 O3K_03970 Escherichia coli O104:H4 str. 2011C-3493 IS621 transposase YP_006777524.1 811015 R 1133852 CDS YP_006777525.1 407480376 13700473 complement(812295..813161) 1 NC_018658.1 COG0625 Glutathione S-transferase; putative S-transferase 813161 13700473 O3K_03975 Escherichia coli O104:H4 str. 2011C-3493 putative S-transferase YP_006777525.1 812295 R 1133852 CDS YP_006777526.1 407480377 13700474 813366..815225 1 NC_018658.1 COG0754 Glutathionylspermidine synthase; bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase 815225 13700474 O3K_03980 Escherichia coli O104:H4 str. 2011C-3493 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase YP_006777526.1 813366 D 1133852 CDS YP_006777527.1 407480378 13700475 815517..817016 1 NC_018658.1 COG0306 Phosphate/sulphate permeases; phosphate transporter 817016 13700475 O3K_03985 Escherichia coli O104:H4 str. 2011C-3493 phosphate transporter YP_006777527.1 815517 D 1133852 CDS YP_006777528.1 407480379 13700476 complement(817065..817757) 1 NC_018658.1 COG0125 Thymidylate kinase; hypothetical protein 817757 13700476 O3K_03990 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777528.1 817065 R 1133852 CDS YP_006777529.1 407480380 13700477 817931..818644 1 NC_018658.1 nucleoside triphosphate hydrolase domain; conserved hypothetical protein; COG0125 Thymidylate kinase; lipoprotein 818644 13700477 O3K_03995 Escherichia coli O104:H4 str. 2011C-3493 lipoprotein YP_006777529.1 817931 D 1133852 CDS YP_006777530.1 407480381 13700478 818676..819434 1 NC_018658.1 COG0178 Excinuclease ATPase subunit; hypothetical protein 819434 13700478 O3K_04000 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777530.1 818676 D 1133852 CDS YP_006777531.1 407480382 13700479 819480..820829 1 NC_018658.1 COG2244 Membrane protein involved in the export of O-antigen and teichoic acid; inner membrane protein 820829 13700479 O3K_04005 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006777531.1 819480 D 1133852 CDS YP_006777532.1 407480383 13700480 820829..821653 1 NC_018658.1 COG0372 Citrate synthase; hypothetical protein 821653 13700480 O3K_04010 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777532.1 820829 D 1133852 CDS YP_006777533.1 407480384 13700481 821665..822225 1 NC_018658.1 COG3054 Predicted transcriptional regulator; transcriptional regulator 822225 13700481 O3K_04015 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator YP_006777533.1 821665 D 1133852 CDS YP_006777534.1 407480385 13700482 822256..823326 1 NC_018658.1 COG0795 Predicted permeases; hypothetical protein 823326 13700482 O3K_04020 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777534.1 822256 D 1133852 CDS YP_006777535.1 407480386 13700483 823323..824402 1 NC_018658.1 COG0795 Predicted permeases; hypothetical protein 824402 13700483 O3K_04025 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777535.1 823323 D 1133852 CDS YP_006777536.1 407480387 13700484 complement(824437..825609) 1 NC_018658.1 COG0156 7-keto-8-aminopelargonate synthetase and related enzymes; hypothetical protein 825609 13700484 O3K_04030 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777536.1 824437 R 1133852 CDS YP_006777537.1 407480388 13700485 complement(825609..825857) 1 NC_018658.1 COG0236 Acyl carrier protein; hypothetical protein 825857 13700485 O3K_04035 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777537.1 825609 R 1133852 CDS YP_006777538.1 407480389 13700486 complement(825889..826803) 1 NC_018658.1 COG0702 Predicted nucleoside-diphosphate-sugar epimerases; hypothetical protein 826803 13700486 O3K_04040 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777538.1 825889 R 1133852 CDS YP_006777539.1 407480390 13700487 complement(826800..828488) 1 NC_018658.1 COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II; acyl-CoA synthetase 828488 13700487 O3K_04045 Escherichia coli O104:H4 str. 2011C-3493 acyl-CoA synthetase YP_006777539.1 826800 R 1133852 CDS YP_006777540.1 407480391 13700488 828892..830034 1 NC_018658.1 putative DNA-binding transcriptional regulator 830034 13700488 O3K_04050 Escherichia coli O104:H4 str. 2011C-3493 putative DNA-binding transcriptional regulator YP_006777540.1 828892 D 1133852 CDS YP_006777541.1 407480392 13700489 complement(830041..830805) 1 NC_018658.1 COG2186 Transcriptional regulators; DNA-binding transcriptional regulator GlcC 830805 13700489 O3K_04055 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator GlcC YP_006777541.1 830041 R 1133852 CDS YP_006777542.1 407480393 13700490 831056..832555 1 NC_018658.1 COG0277 FAD/FMN-containing dehydrogenases; glycolate oxidase subunit GlcD 832555 13700490 O3K_04060 Escherichia coli O104:H4 str. 2011C-3493 glycolate oxidase subunit GlcD YP_006777542.1 831056 D 1133852 CDS YP_006777543.1 407480394 13700491 832555..833607 1 NC_018658.1 COG0277 FAD/FMN-containing dehydrogenases; glycolate oxidase FAD binding subunit 833607 glcE 13700491 glcE Escherichia coli O104:H4 str. 2011C-3493 glycolate oxidase FAD binding subunit YP_006777543.1 832555 D 1133852 CDS YP_006777544.1 407480395 13700492 833618..834841 1 NC_018658.1 COG0247 Fe-S oxidoreductase; glycolate oxidase iron-sulfur subunit 834841 glcF 13700492 glcF Escherichia coli O104:H4 str. 2011C-3493 glycolate oxidase iron-sulfur subunit YP_006777544.1 833618 D 1133852 CDS YP_006777545.1 407480396 13700493 834846..835250 1 NC_018658.1 COG3193 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol; hypothetical protein 835250 13700493 O3K_04075 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777545.1 834846 D 1133852 CDS YP_006777546.1 407480397 13700494 835272..837443 1 NC_018658.1 COG2225 Malate synthase; malate synthase G 837443 13700494 O3K_04080 Escherichia coli O104:H4 str. 2011C-3493 malate synthase G YP_006777546.1 835272 D 1133852 CDS YP_006777547.1 407480398 13700495 837799..839481 1 NC_018658.1 COG1620 L-lactate permease; glycolate transporter 839481 13700495 O3K_04085 Escherichia coli O104:H4 str. 2011C-3493 glycolate transporter YP_006777547.1 837799 D 1133852 CDS YP_006777548.1 407480399 13700496 complement(839607..839816) 1 NC_018658.1 hypothetical protein 839816 13700496 O3K_04090 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777548.1 839607 R 1133852 CDS YP_006777549.1 407480400 13700497 840099..844532 1 NC_018658.1 inner membrane lipoprotein 844532 13700497 O3K_04095 Escherichia coli O104:H4 str. 2011C-3493 inner membrane lipoprotein YP_006777549.1 840099 D 1133852 CDS YP_006777550.1 407480401 13700498 844672..845481 1 NC_018658.1 COG1989 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases; bifunctional prepilin leader peptidase/methylase 845481 13700498 O3K_04100 Escherichia coli O104:H4 str. 2011C-3493 bifunctional prepilin leader peptidase/methylase YP_006777550.1 844672 D 1133852 CDS YP_006777551.1 407480402 13700499 845547..845957 1 NC_018658.1 hypothetical protein 845957 13700499 O3K_04105 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777551.1 845547 D 1133852 CDS YP_006777552.1 407480403 13700500 845975..846934 1 NC_018658.1 COG3031 Type II secretory pathway, component PulC; putative type II secretion protein GspC 846934 13700500 O3K_04110 Escherichia coli O104:H4 str. 2011C-3493 putative type II secretion protein GspC YP_006777552.1 845975 D 1133852 CDS YP_006777553.1 407480404 13700501 846964..849024 1 NC_018658.1 COG1450 Type II secretory pathway, component PulD; general secretion pathway protein D 849024 13700501 O3K_04115 Escherichia coli O104:H4 str. 2011C-3493 general secretion pathway protein D YP_006777553.1 846964 D 1133852 CDS YP_006777554.1 407480405 13700502 849024..850517 1 NC_018658.1 COG2804 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB; general secretion pathway protein E 850517 13700502 O3K_04120 Escherichia coli O104:H4 str. 2011C-3493 general secretion pathway protein E YP_006777554.1 849024 D 1133852 CDS YP_006777555.1 407480406 13700503 850517..851740 1 NC_018658.1 COG1459 Type II secretory pathway, component PulF; General secretion pathway protein F 851740 13700503 O3K_04125 Escherichia coli O104:H4 str. 2011C-3493 General secretion pathway protein F YP_006777555.1 850517 D 1133852 CDS YP_006777556.1 407480407 13700504 851757..852212 1 NC_018658.1 COG2165 Type II secretory pathway, pseudopilin PulG; putative general secretion pathway protein G precursor 852212 13700504 O3K_04130 Escherichia coli O104:H4 str. 2011C-3493 putative general secretion pathway protein G precursor YP_006777556.1 851757 D 1133852 CDS YP_006777557.1 407480408 13700505 852216..852779 1 NC_018658.1 COG2165 Type II secretory pathway, pseudopilin PulG; general secretion pathway protein H 852779 13700505 O3K_04135 Escherichia coli O104:H4 str. 2011C-3493 general secretion pathway protein H YP_006777557.1 852216 D 1133852 CDS YP_006777558.1 407480409 13700506 852776..853147 1 NC_018658.1 COG2165 Type II secretory pathway, pseudopilin PulG; putative type II secretion protein 853147 13700506 O3K_04140 Escherichia coli O104:H4 str. 2011C-3493 putative type II secretion protein YP_006777558.1 852776 D 1133852 CDS YP_006777559.1 407480410 13700507 853144..853743 1 NC_018658.1 COG4795 Type II secretory pathway, component PulJ; general secretion pathway protein J 853743 13700507 O3K_04145 Escherichia coli O104:H4 str. 2011C-3493 general secretion pathway protein J YP_006777559.1 853144 D 1133852 CDS YP_006777560.1 407480411 13700508 853746..854723 1 NC_018658.1 COG3156 Type II secretory pathway, component PulK; type II secretion protein (GspK-like) 854723 13700508 O3K_04150 Escherichia coli O104:H4 str. 2011C-3493 type II secretion protein (GspK-like) YP_006777560.1 853746 D 1133852 CDS YP_006777561.1 407480412 13700509 854720..855898 1 NC_018658.1 COG3297 Type II secretory pathway, component PulL; GspL-like protein 855898 13700509 O3K_04155 Escherichia coli O104:H4 str. 2011C-3493 GspL-like protein YP_006777561.1 854720 D 1133852 CDS YP_006777562.1 407480413 13700510 855900..856436 1 NC_018658.1 COG3149 Type II secretory pathway, component PulM; putative general secretion pathway protein YghD 856436 13700510 O3K_04160 Escherichia coli O104:H4 str. 2011C-3493 putative general secretion pathway protein YghD YP_006777562.1 855900 D 1133852 CDS YP_006777563.1 407480414 13700511 complement(856717..857559) 1 NC_018658.1 hypothetical protein 857559 13700511 O3K_04165 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777563.1 856717 R 1133852 CDS YP_006777564.1 407480415 13700512 complement(857644..858066) 1 NC_018658.1 hypothetical protein 858066 13700512 O3K_04170 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777564.1 857644 R 1133852 CDS YP_006777565.1 407480416 13700513 complement(858063..858440) 1 NC_018658.1 toxin of the YeeV-YeeU toxin-antitoxin system 858440 13700513 O3K_04175 Escherichia coli O104:H4 str. 2011C-3493 toxin of the YeeV-YeeU toxin-antitoxin system YP_006777565.1 858063 R 1133852 CDS YP_006777566.1 407480417 13700514 complement(858487..858864) 1 NC_018658.1 antitoxin of the YeeV-YeeU toxin-antitoxin system, CP4-44 prophage 858864 13700514 O3K_04180 Escherichia coli O104:H4 str. 2011C-3493 antitoxin of the YeeV-YeeU toxin-antitoxin system, CP4-44 prophage YP_006777566.1 858487 R 1133852 CDS YP_006777567.1 407480418 13700515 complement(858944..859165) 1 NC_018658.1 hypothetical protein 859165 13700515 O3K_04185 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777567.1 858944 R 1133852 CDS YP_006777568.1 407480419 13700516 complement(859252..859728) 1 NC_018658.1 COG2003 DNA repair proteins; putative DNA repair protein, CP4-44 prophage 859728 13700516 O3K_04190 Escherichia coli O104:H4 str. 2011C-3493 putative DNA repair protein, CP4-44 prophage YP_006777568.1 859252 R 1133852 CDS YP_006777569.1 407480420 13700517 complement(859744..860217) 1 NC_018658.1 hypothetical protein 860217 13700517 O3K_04195 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777569.1 859744 R 1133852 CDS YP_006777570.1 407480421 13700518 complement(860518..861336) 1 NC_018658.1 hypothetical protein 861336 13700518 O3K_04200 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777570.1 860518 R 1133852 CDS YP_006777571.1 407480422 13700519 complement(861436..861669) 1 NC_018658.1 hypothetical protein 861669 13700519 O3K_04205 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777571.1 861436 R 1133852 CDS YP_006777572.1 407480423 13700520 complement(861748..862203) 1 NC_018658.1 hypothetical protein 862203 13700520 O3K_04210 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777572.1 861748 R 1133852 CDS YP_006777573.1 407480424 13700521 complement(862279..864795) 1 NC_018658.1 membrane protein, yeeR 864795 13700521 O3K_04215 Escherichia coli O104:H4 str. 2011C-3493 membrane protein, yeeR YP_006777573.1 862279 R 1133852 CDS YP_006777574.1 407480425 13700522 complement(864916..868035) 1 NC_018658.1 COG2931 RTX toxins and related Ca2+-binding proteins; antigen 43 (Ag43) phase-variable biofilm formation autotransporter, CP4-44 prophage 868035 13700522 O3K_04220 Escherichia coli O104:H4 str. 2011C-3493 antigen 43 (Ag43) phase-variable biofilm formation autotransporter, CP4-44 prophage YP_006777574.1 864916 R 1133852 CDS YP_006777575.1 407480426 13700523 complement(868369..869241) 1 NC_018658.1 COG3596 Predicted GTPase; GTPase 869241 13700523 O3K_04225 Escherichia coli O104:H4 str. 2011C-3493 GTPase YP_006777575.1 868369 R 1133852 CDS YP_006777576.1 407480427 13700524 complement(869351..870370) 1 NC_018658.1 hypothetical protein 870370 13700524 O3K_04230 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777576.1 869351 R 1133852 CDS YP_006777577.1 407480428 13700525 complement(871865..872437) 1 NC_018658.1 hypothetical protein 872437 13700525 O3K_04235 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777577.1 871865 R 1133852 CDS YP_006777578.1 407480429 13700526 complement(872523..872729) 1 NC_018658.1 COG3311 Predicted transcriptional regulator; putative Prophage CP4-57 regulatory protein 872729 13700526 O3K_04240 Escherichia coli O104:H4 str. 2011C-3493 putative Prophage CP4-57 regulatory protein YP_006777578.1 872523 R 1133852 CDS YP_006777579.1 407480430 13700527 873428..873640 1 NC_018658.1 hemolysin expression-modulating protein 873640 13700527 O3K_04245 Escherichia coli O104:H4 str. 2011C-3493 hemolysin expression-modulating protein YP_006777579.1 873428 D 1133852 CDS YP_006777580.1 407480431 13700528 874257..874826 1 NC_018658.1 hypothetical protein 874826 13700528 O3K_04250 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777580.1 874257 D 1133852 CDS YP_006777581.1 407480432 13700529 874994..875377 1 NC_018658.1 hypothetical protein 875377 13700529 O3K_04255 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777581.1 874994 D 1133852 CDS YP_006777582.1 407480433 13700530 875367..875786 1 NC_018658.1 hypothetical protein 875786 13700530 O3K_04260 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777582.1 875367 D 1133852 CDS YP_006777583.1 407480434 13700531 875792..875974 1 NC_018658.1 hypothetical protein 875974 13700531 O3K_04265 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777583.1 875792 D 1133852 CDS YP_006777584.1 407480435 13700532 876095..876718 1 NC_018658.1 hypothetical protein 876718 13700532 O3K_04270 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777584.1 876095 D 1133852 CDS YP_006777585.1 407480436 13700533 876814..877047 1 NC_018658.1 hypothetical protein 877047 13700533 O3K_04275 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777585.1 876814 D 1133852 CDS YP_006777586.1 407480437 13700534 complement(877100..877291) 1 NC_018658.1 hypothetical protein 877291 13700534 O3K_04280 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777586.1 877100 R 1133852 CDS YP_006777587.1 407480438 13700535 877798..878295 1 NC_018658.1 COG3516 Uncharacterized protein conserved in bacteria; hypothetical protein 878295 13700535 O3K_04285 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777587.1 877798 D 1133852 CDS YP_006777588.1 407480439 13700536 878317..879678 1 NC_018658.1 COG3517 Uncharacterized protein conserved in bacteria; hypothetical protein 879678 13700536 O3K_04290 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777588.1 878317 D 1133852 CDS YP_006777589.1 407480440 13700537 879780..881024 1 NC_018658.1 hypothetical protein 881024 13700537 O3K_04295 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777589.1 879780 D 1133852 CDS YP_006777590.1 407480441 13700538 881341..883005 1 NC_018658.1 COG0210 Superfamily I DNA and RNA helicases; UvrD/REP helicase 883005 13700538 O3K_04300 Escherichia coli O104:H4 str. 2011C-3493 UvrD/REP helicase YP_006777590.1 881341 D 1133852 CDS YP_006777591.1 407480442 13700539 883067..883375 1 NC_018658.1 hypothetical protein 883375 13700539 O3K_04305 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777591.1 883067 D 1133852 CDS YP_006777592.1 407480443 13700540 883430..883657 1 NC_018658.1 COG1475 Predicted transcriptional regulators; transcriptional regulator IbrB 883657 13700540 O3K_04310 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator IbrB YP_006777592.1 883430 D 1133852 CDS YP_006777593.1 407480444 13700541 883736..884005 1 NC_018658.1 transcriptional regulator 884005 13700541 O3K_04315 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator YP_006777593.1 883736 D 1133852 CDS YP_006777594.1 407480445 13700542 884026..884670 1 NC_018658.1 hypothetical protein 884670 13700542 O3K_04320 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777594.1 884026 D 1133852 CDS YP_006777595.1 407480446 13700543 884736..885059 1 NC_018658.1 hypothetical protein 885059 13700543 O3K_04325 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777595.1 884736 D 1133852 CDS YP_006777596.1 407480447 13700544 complement(885113..885508) 1 NC_018658.1 COG2801 Transposase and inactivated derivatives; hypothetical protein 885508 13700544 O3K_04330 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777596.1 885113 R 1133852 CDS YP_006777597.1 407480448 13700545 885942..886265 1 NC_018658.1 hypothetical protein 886265 13700545 O3K_04340 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777597.1 885942 D 1133852 CDS YP_006777598.1 407480449 13700546 887786..888262 1 NC_018658.1 COG3516 Uncharacterized protein conserved in bacteria; hypothetical protein 888262 13700546 O3K_04355 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777598.1 887786 D 1133852 CDS YP_006777599.1 407480450 13700547 888265..889743 1 NC_018658.1 COG3517 Uncharacterized protein conserved in bacteria; hypothetical protein 889743 13700547 O3K_04360 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777599.1 888265 D 1133852 CDS YP_006777600.1 407480451 13700548 889765..890259 1 NC_018658.1 hypothetical protein 890259 13700548 O3K_04365 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777600.1 889765 D 1133852 CDS YP_006777601.1 407480452 13700549 890269..890691 1 NC_018658.1 hypothetical protein 890691 13700549 O3K_04370 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777601.1 890269 D 1133852 CDS YP_006777602.1 407480453 13700550 complement(890727..891023) 1 NC_018658.1 hypothetical protein 891023 13700550 O3K_04375 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777602.1 890727 R 1133852 CDS YP_006777603.1 407480454 13700551 891155..892486 1 NC_018658.1 COG3519 Uncharacterized protein conserved in bacteria; hypothetical protein 892486 13700551 O3K_04380 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777603.1 891155 D 1133852 CDS YP_006777604.1 407480455 13700552 892477..893409 1 NC_018658.1 COG3520 Uncharacterized protein conserved in bacteria; hypothetical protein 893409 13700552 O3K_04385 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777604.1 892477 D 1133852 CDS YP_006777605.1 407480456 13700553 893422..895404 1 NC_018658.1 COG3501 Uncharacterized protein conserved in bacteria; hypothetical protein 895404 13700553 O3K_04390 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777605.1 893422 D 1133852 CDS YP_006777606.1 407480457 13700554 895415..895882 1 NC_018658.1 hypothetical protein 895882 13700554 O3K_04395 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777606.1 895415 D 1133852 CDS YP_006777607.1 407480458 13700555 895886..896191 1 NC_018658.1 COG4104 Uncharacterized conserved protein; hypothetical protein 896191 13700555 O3K_04400 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777607.1 895886 D 1133852 CDS YP_006777608.1 407480459 13700556 896195..897271 1 NC_018658.1 COG3515 Uncharacterized protein conserved in bacteria; hypothetical protein 897271 13700556 O3K_04405 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777608.1 896195 D 1133852 CDS YP_006777609.1 407480460 13700557 897279..897830 1 NC_018658.1 hypothetical protein 897830 13700557 O3K_04410 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777609.1 897279 D 1133852 CDS YP_006777610.1 407480461 13700558 897849..899261 1 NC_018658.1 COG3522 Uncharacterized protein conserved in bacteria; hypothetical protein 899261 13700558 O3K_04415 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777610.1 897849 D 1133852 CDS YP_006777611.1 407480462 13700559 899289..899603 1 NC_018658.1 COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II; hypothetical protein 899603 13700559 O3K_04420 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777611.1 899289 D 1133852 CDS YP_006777612.1 407480463 13700560 899600..900190 1 NC_018658.1 COG3455 Uncharacterized protein conserved in bacteria; hypothetical protein 900190 13700560 O3K_04425 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777612.1 899600 D 1133852 CDS YP_006777613.1 407480464 13700561 900187..903600 1 NC_018658.1 COG3523 Uncharacterized protein conserved in bacteria; hypothetical protein 903600 13700561 O3K_04430 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777613.1 900187 D 1133852 CDS YP_006777614.1 407480465 13700562 903604..906153 1 NC_018658.1 COG0542 ATPases with chaperone activity, ATP-binding subunit; hypothetical protein 906153 13700562 O3K_04435 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777614.1 903604 D 1133852 CDS YP_006777615.1 407480466 13700563 909444..909830 1 NC_018658.1 COG2801 Transposase and inactivated derivatives; IS629 ORF2; transposase 909830 13700563 O3K_04455 Escherichia coli O104:H4 str. 2011C-3493 transposase YP_006777615.1 909444 D 1133852 CDS YP_006777616.1 407480467 13700564 911588..912154 1 NC_018658.1 hypothetical protein 912154 13700564 O3K_04460 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777616.1 911588 D 1133852 CDS YP_006777617.1 407480468 13700565 complement(912299..912532) 1 NC_018658.1 hypothetical protein 912532 13700565 O3K_04465 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777617.1 912299 R 1133852 CDS YP_006777618.1 407480469 13700566 912633..913787 1 NC_018658.1 hypothetical protein 913787 13700566 O3K_04470 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777618.1 912633 D 1133852 CDS YP_006777619.1 407480470 13700567 914178..914579 1 NC_018658.1 hypothetical protein 914579 13700567 O3K_04475 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777619.1 914178 D 1133852 CDS YP_006777620.1 407480471 13700568 complement(914853..915038) 1 NC_018658.1 COG3436 Transposase and inactivated derivatives; hypothetical protein 915038 13700568 O3K_04480 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777620.1 914853 R 1133852 CDS YP_006777621.1 407480472 13700569 916373..916636 1 NC_018658.1 COG2801 Transposase and inactivated derivatives; IS150 ORF B; transposase 916636 13700569 O3K_04495 Escherichia coli O104:H4 str. 2011C-3493 transposase YP_006777621.1 916373 D 1133852 CDS YP_006777622.1 407480473 13700570 complement(916969..917367) 1 NC_018658.1 COG3436 Transposase and inactivated derivatives; transposase 917367 13700570 O3K_04500 Escherichia coli O104:H4 str. 2011C-3493 transposase YP_006777622.1 916969 R 1133852 CDS YP_006777623.1 407480474 13700571 complement(917432..918556) 1 NC_018658.1 COG4584 Transposase and inactivated derivatives; transposase 918556 13700571 O3K_04505 Escherichia coli O104:H4 str. 2011C-3493 transposase YP_006777623.1 917432 R 1133852 CDS YP_006777624.1 407480475 13700572 918777..919286 1 NC_018658.1 COG3436 Transposase and inactivated derivatives; hypothetical protein 919286 13700572 O3K_04510 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777624.1 918777 D 1133852 CDS YP_006777625.1 407480476 13700573 919349..919567 1 NC_018658.1 COG3328 Transposase and inactivated derivatives; transposase 919567 13700573 O3K_04515 Escherichia coli O104:H4 str. 2011C-3493 transposase YP_006777625.1 919349 D 1133852 CDS YP_006777626.1 407480477 13700574 complement(919718..923836) 1 NC_018658.1 COG3468 Type V secretory pathway, adhesin AidA; Serine protease pic precursor (ShMu) 923836 13700574 O3K_04520 Escherichia coli O104:H4 str. 2011C-3493 Serine protease pic precursor (ShMu) YP_006777626.1 919718 R 1133852 CDS YP_006777627.1 407480478 13700575 complement(924001..924387) 1 NC_018658.1 COG2801 Transposase and inactivated derivatives; IS629 ORF2; transposase 924387 13700575 O3K_04525 Escherichia coli O104:H4 str. 2011C-3493 transposase YP_006777627.1 924001 R 1133852 CDS YP_006777628.1 407480479 13700576 complement(926678..926917) 1 NC_018658.1 COG2801 Transposase and inactivated derivatives; hypothetical protein 926917 13700576 O3K_04540 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777628.1 926678 R 1133852 CDS YP_006777629.1 407480480 13700577 927234..928385 1 NC_018658.1 COG2826 Transposase and inactivated derivatives, IS30 family; transposase for IS30 928385 13700577 O3K_04545 Escherichia coli O104:H4 str. 2011C-3493 transposase for IS30 YP_006777629.1 927234 D 1133852 CDS YP_006777630.1 407480481 13700578 complement(928305..928691) 1 NC_018658.1 COG2963 Transposase and inactivated derivatives; IS3 family protein; transposase ORF A, IS3 family protein 928691 13700578 O3K_04550 Escherichia coli O104:H4 str. 2011C-3493 transposase ORF A, IS3 family protein YP_006777630.1 928305 R 1133852 CDS YP_006777631.1 407480482 13700579 complement(928725..929018) 1 NC_018658.1 hypothetical protein 929018 13700579 O3K_04555 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777631.1 928725 R 1133852 CDS YP_006777632.1 407480483 13700580 complement(929107..931977) 1 NC_018658.1 COG3421 Uncharacterized protein conserved in bacteria; PstII restriction-modification enzyme Res subunit 931977 13700580 O3K_04560 Escherichia coli O104:H4 str. 2011C-3493 PstII restriction-modification enzyme Res subunit YP_006777632.1 929107 R 1133852 CDS YP_006777633.1 407480484 13700581 complement(931980..933608) 1 NC_018658.1 COG2189 Adenine specific DNA methylase Mod; DNA methylase N-4/N-6 933608 13700581 O3K_04565 Escherichia coli O104:H4 str. 2011C-3493 DNA methylase N-4/N-6 YP_006777633.1 931980 R 1133852 CDS YP_006777634.1 407480485 13700582 complement(933618..936005) 1 NC_018658.1 COG1404 Subtilisin-like serine proteases; serine protease 936005 13700582 O3K_04570 Escherichia coli O104:H4 str. 2011C-3493 serine protease YP_006777634.1 933618 R 1133852 CDS YP_006777635.1 407480486 13700583 complement(936015..936995) 1 NC_018658.1 COG0464 ATPases of the AAA+ class; ATPase 936995 13700583 O3K_04575 Escherichia coli O104:H4 str. 2011C-3493 ATPase YP_006777635.1 936015 R 1133852 CDS YP_006777636.1 407480487 13700584 complement(937021..939870) 1 NC_018658.1 COG0553 Superfamily II DNA/RNA helicases, SNF2 family; Helicase 939870 13700584 O3K_04580 Escherichia coli O104:H4 str. 2011C-3493 Helicase YP_006777636.1 937021 R 1133852 CDS YP_006777637.1 407480488 13700585 940171..940353 1 NC_018658.1 hypothetical protein 940353 13700585 O3K_04585 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777637.1 940171 D 1133852 CDS YP_006777638.1 407480489 13700586 940281..940874 1 NC_018658.1 hypothetical protein 940874 13700586 O3K_04590 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777638.1 940281 D 1133852 CDS YP_006777639.1 407480490 13700587 complement(941340..941603) 1 NC_018658.1 hypothetical protein 941603 13700587 O3K_04595 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777639.1 941340 R 1133852 CDS YP_006777640.1 407480491 13700588 complement(941744..942247) 1 NC_018658.1 COG1662 Transposase and inactivated derivatives, IS1 family; putative IS1 transposase InsAB' 942247 13700588 O3K_04600 Escherichia coli O104:H4 str. 2011C-3493 putative IS1 transposase InsAB' YP_006777640.1 941744 R 1133852 CDS YP_006777641.1 407480492 13700589 complement(942166..942441) 1 NC_018658.1 COG3677 Transposase and inactivated derivatives; IS1 repressor protein InsA 942441 13700589 O3K_04605 Escherichia coli O104:H4 str. 2011C-3493 IS1 repressor protein InsA YP_006777641.1 942166 R 1133852 CDS YP_006777642.1 407480493 13700590 complement(942854..944116) 1 NC_018658.1 COG0582 Integrase; Prophage integrase 944116 13700590 O3K_04610 Escherichia coli O104:H4 str. 2011C-3493 Prophage integrase YP_006777642.1 942854 R 1133852 CDS YP_006777643.1 407480494 13700592 complement(944495..945202) 1 NC_018658.1 COG1811 Uncharacterized membrane protein, possible Na+ channel or pump; hypothetical protein 945202 13700592 O3K_04615 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777643.1 944495 R 1133852 CDS YP_006777644.1 407480495 13700593 945600..947735 1 NC_018658.1 COG1982 Arginine/lysine/ornithine decarboxylases; ornithine decarboxylase 947735 13700593 O3K_04620 Escherichia coli O104:H4 str. 2011C-3493 ornithine decarboxylase YP_006777644.1 945600 D 1133852 CDS YP_006777645.1 407480496 13700594 complement(947785..949041) 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; nucleoside transport, permease 949041 13700594 O3K_04625 Escherichia coli O104:H4 str. 2011C-3493 nucleoside transport, permease YP_006777645.1 947785 R 1133852 CDS YP_006777646.1 407480497 13700595 complement(949243..950322) 1 NC_018658.1 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains); murein transglycosylase C 950322 mltC 13700595 mltC Escherichia coli O104:H4 str. 2011C-3493 murein transglycosylase C YP_006777646.1 949243 R 1133852 CDS YP_006777647.1 407480498 13700596 complement(950387..950662) 1 NC_018658.1 COG2924 Fe-S cluster protector protein; oxidative damage protection protein 950662 13700596 O3K_04635 Escherichia coli O104:H4 str. 2011C-3493 oxidative damage protection protein YP_006777647.1 950387 R 1133852 CDS YP_006777648.1 407480499 13700597 complement(950690..951742) 1 NC_018658.1 COG1194 A/G-specific DNA glycosylase; adenine DNA glycosylase 951742 13700597 O3K_04640 Escherichia coli O104:H4 str. 2011C-3493 adenine DNA glycosylase YP_006777648.1 950690 R 1133852 CDS YP_006777649.1 407480500 13700598 951903..952622 1 NC_018658.1 COG0220 Predicted S-adenosylmethionine-dependent methyltransferase; tRNA (guanine-N(7)-)-methyltransferase 952622 trmB 13700598 trmB Escherichia coli O104:H4 str. 2011C-3493 tRNA (guanine-N(7)-)-methyltransferase YP_006777649.1 951903 D 1133852 CDS YP_006777650.1 407480501 13700599 952622..952948 1 NC_018658.1 COG3171 Uncharacterized protein conserved in bacteria; hypothetical protein 952948 13700599 O3K_04650 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777650.1 952622 D 1133852 CDS YP_006777651.1 407480502 13700600 952971..953111 1 NC_018658.1 hypothetical protein 953111 13700600 O3K_04655 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777651.1 952971 D 1133852 CDS YP_006777652.1 407480503 13700601 953132..953851 1 NC_018658.1 hypothetical protein 953851 13700601 O3K_04660 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777652.1 953132 D 1133852 CDS YP_006777653.1 407480504 13700602 954027..955073 1 NC_018658.1 COG0252 L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D; L-asparaginase II 955073 ansB 13700602 ansB Escherichia coli O104:H4 str. 2011C-3493 L-asparaginase II YP_006777653.1 954027 D 1133852 CDS YP_006777654.1 407480505 13700603 955190..956197 1 NC_018658.1 hypothetical protein 956197 13700603 O3K_04670 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777654.1 955190 D 1133852 CDS YP_006777655.1 407480506 13700604 complement(956352..957488) 1 NC_018658.1 COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases; HemN family oxidoreductase 957488 13700604 O3K_04675 Escherichia coli O104:H4 str. 2011C-3493 HemN family oxidoreductase YP_006777655.1 956352 R 1133852 CDS YP_006777656.1 407480507 13700605 complement(957481..958074) 1 NC_018658.1 COG0127 Xanthosine triphosphate pyrophosphatase; dITP/XTP pyrophosphatase 958074 13700605 O3K_04680 Escherichia coli O104:H4 str. 2011C-3493 dITP/XTP pyrophosphatase YP_006777656.1 957481 R 1133852 CDS YP_006777657.1 407480508 13700606 complement(958082..958372) 1 NC_018658.1 COG1872 Uncharacterized conserved protein; hypothetical protein 958372 13700606 O3K_04685 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777657.1 958082 R 1133852 CDS YP_006777658.1 407480509 13700607 complement(958369..958935) 1 NC_018658.1 COG0762 Predicted integral membrane protein; hypothetical protein 958935 13700607 O3K_04690 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777658.1 958369 R 1133852 CDS YP_006777659.1 407480510 13700608 complement(958953..959657) 1 NC_018658.1 COG0325 Predicted enzyme with a TIM-barrel fold; hypothetical protein 959657 13700608 O3K_04695 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777659.1 958953 R 1133852 CDS YP_006777660.1 407480511 13700609 959675..960655 1 NC_018658.1 COG2805 Tfp pilus assembly protein, pilus retraction ATPase PilT; transporter 960655 13700609 O3K_04700 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006777660.1 959675 D 1133852 CDS YP_006777661.1 407480512 13700610 complement(960831..961247) 1 NC_018658.1 COG0816 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis); Holliday junction resolvase-like protein 961247 13700610 O3K_04705 Escherichia coli O104:H4 str. 2011C-3493 Holliday junction resolvase-like protein YP_006777661.1 960831 R 1133852 CDS YP_006777662.1 407480513 13700611 complement(961247..961810) 1 NC_018658.1 COG1678 Putative transcriptional regulator; hypothetical protein 961810 13700611 O3K_04710 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777662.1 961247 R 1133852 CDS YP_006777663.1 407480514 13700612 complement(961919..962869) 1 NC_018658.1 COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase); glutathione synthetase 962869 13700612 O3K_04715 Escherichia coli O104:H4 str. 2011C-3493 glutathione synthetase YP_006777663.1 961919 R 1133852 CDS YP_006777664.1 407480515 13700613 complement(962882..963613) 1 NC_018658.1 COG1385 Uncharacterized protein conserved in bacteria; 16S ribosomal RNA methyltransferase RsmE 963613 13700613 O3K_04720 Escherichia coli O104:H4 str. 2011C-3493 16S ribosomal RNA methyltransferase RsmE YP_006777664.1 962882 R 1133852 CDS YP_006777665.1 407480516 13700614 complement(963693..964400) 1 NC_018658.1 COG2356 Endonuclease I; DNA-specific endonuclease I 964400 13700614 O3K_04725 Escherichia coli O104:H4 str. 2011C-3493 DNA-specific endonuclease I YP_006777665.1 963693 R 1133852 CDS YP_006777666.1 407480517 13700615 complement(964495..964992) 1 NC_018658.1 COG3091 Uncharacterized protein conserved in bacteria; hypothetical protein 964992 13700615 O3K_04730 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777666.1 964495 R 1133852 CDS YP_006777667.1 407480518 13700616 complement(965069..966463) 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; D-galactose transporter GalP 966463 13700616 O3K_04735 Escherichia coli O104:H4 str. 2011C-3493 D-galactose transporter GalP YP_006777667.1 965069 R 1133852 CDS YP_006777668.1 407480519 13700617 complement(966899..968053) 1 NC_018658.1 COG0192 S-adenosylmethionine synthetase; S-adenosylmethionine synthetase 968053 13700617 O3K_04740 Escherichia coli O104:H4 str. 2011C-3493 S-adenosylmethionine synthetase YP_006777668.1 966899 R 1133852 CDS YP_006777669.1 407480520 13700618 968109..968360 1 NC_018658.1 hypothetical protein 968360 13700618 O3K_04745 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777669.1 968109 D 1133852 CDS YP_006777670.1 407480521 13700619 968693..968839 1 NC_018658.1 hypothetical protein 968839 13700619 O3K_04750 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777670.1 968693 D 1133852 CDS YP_006777671.1 407480522 13700620 968848..970824 1 NC_018658.1 COG1166 Arginine decarboxylase (spermidine biosynthesis); arginine decarboxylase 970824 13700620 O3K_04755 Escherichia coli O104:H4 str. 2011C-3493 arginine decarboxylase YP_006777671.1 968848 D 1133852 CDS YP_006777672.1 407480523 13700621 970970..971701 1 NC_018658.1 hypothetical protein 971701 13700621 O3K_04760 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777672.1 970970 D 1133852 CDS YP_006777673.1 407480524 13700622 971837..972757 1 NC_018658.1 COG0010 Arginase/agmatinase/formimionoglutamate hydrolase, arginase family; agmatinase 972757 13700622 O3K_04765 Escherichia coli O104:H4 str. 2011C-3493 agmatinase YP_006777673.1 971837 D 1133852 CDS YP_006777674.1 407480525 13700623 complement(972963..973721) 1 NC_018658.1 COG0501 Zn-dependent protease with chaperone function; peptidase 973721 13700623 O3K_04770 Escherichia coli O104:H4 str. 2011C-3493 peptidase YP_006777674.1 972963 R 1133852 CDS YP_006777675.1 407480526 13700624 973999..975990 1 NC_018658.1 COG0021 Transketolase; transketolase 975990 13700624 O3K_04775 Escherichia coli O104:H4 str. 2011C-3493 transketolase YP_006777675.1 973999 D 1133852 CDS YP_006777676.1 407480527 13700625 976304..976747 1 NC_018658.1 COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type); PTS system mannitol-specific transporter subunit IIA 976747 cmtB 13700625 cmtB Escherichia coli O104:H4 str. 2011C-3493 PTS system mannitol-specific transporter subunit IIA YP_006777676.1 976304 D 1133852 CDS YP_006777677.1 407480528 13700626 976775..978163 1 NC_018658.1 COG2213 Phosphotransferase system, mannitol-specific IIBC component; PTS system mannitol-specific transporter subunit IIBC 978163 13700626 O3K_04785 Escherichia coli O104:H4 str. 2011C-3493 PTS system mannitol-specific transporter subunit IIBC YP_006777677.1 976775 D 1133852 CDS YP_006777678.1 407480529 13700627 978178..979455 1 NC_018658.1 COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases; putative dehydrogenase 979455 13700627 O3K_04790 Escherichia coli O104:H4 str. 2011C-3493 putative dehydrogenase YP_006777678.1 978178 D 1133852 CDS YP_006777679.1 407480530 13700628 979452..980417 1 NC_018658.1 COG1494 Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins; fructose-1,6-bisphosphatase II-like protein 980417 13700628 O3K_04795 Escherichia coli O104:H4 str. 2011C-3493 fructose-1,6-bisphosphatase II-like protein YP_006777679.1 979452 D 1133852 CDS YP_006777680.1 407480531 13700629 980439..980948 1 NC_018658.1 COG3722 Transcriptional regulator; putative DNA-binding transcriptional regulator 980948 13700629 O3K_04800 Escherichia coli O104:H4 str. 2011C-3493 putative DNA-binding transcriptional regulator YP_006777680.1 980439 D 1133852 CDS YP_006777681.1 407480532 13700630 980945..981658 1 NC_018658.1 COG1072 Panthothenate kinase; nucleoside triphosphate hydrolase domain-containing protein 981658 13700630 O3K_04805 Escherichia coli O104:H4 str. 2011C-3493 nucleoside triphosphate hydrolase domain-containing protein YP_006777681.1 980945 D 1133852 CDS YP_006777682.1 407480533 13700631 complement(981630..982307) 1 NC_018658.1 COG1118 ABC-type sulfate/molybdate transport systems, ATPase component; ABC transporter ATP-binding protein 982307 13700631 O3K_04810 Escherichia coli O104:H4 str. 2011C-3493 ABC transporter ATP-binding protein YP_006777682.1 981630 R 1133852 CDS YP_006777683.1 407480534 13700632 complement(982301..982978) 1 NC_018658.1 COG1122 ABC-type cobalt transport system, ATPase component; ABC transporter ATP-binding protein 982978 13700632 O3K_04815 Escherichia coli O104:H4 str. 2011C-3493 ABC transporter ATP-binding protein YP_006777683.1 982301 R 1133852 CDS YP_006777684.1 407480535 13700633 complement(982966..983673) 1 NC_018658.1 COG0619 ABC-type cobalt transport system, permease component CbiQ and related transporters; lipoprotein 983673 13700633 O3K_04820 Escherichia coli O104:H4 str. 2011C-3493 lipoprotein YP_006777684.1 982966 R 1133852 CDS YP_006777685.1 407480536 13700634 complement(983674..984252) 1 NC_018658.1 transporter 984252 13700634 O3K_04825 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006777685.1 983674 R 1133852 CDS YP_006777686.1 407480537 13700635 complement(984275..984706) 1 NC_018658.1 COG1661 Predicted DNA-binding protein with PD1-like DNA-binding motif; DNA-binding protein 984706 13700635 O3K_04830 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding protein YP_006777686.1 984275 R 1133852 CDS YP_006777687.1 407480538 13700636 985078..986097 1 NC_018658.1 COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; erythrose 4-phosphate dehydrogenase 986097 13700636 O3K_04835 Escherichia coli O104:H4 str. 2011C-3493 erythrose 4-phosphate dehydrogenase YP_006777687.1 985078 D 1133852 CDS YP_006777688.1 407480539 13700637 986147..987310 1 NC_018658.1 COG0126 3-phosphoglycerate kinase; phosphoglycerate kinase 987310 pgk 13700637 pgk Escherichia coli O104:H4 str. 2011C-3493 phosphoglycerate kinase YP_006777688.1 986147 D 1133852 CDS YP_006777689.1 407480540 13700638 987525..988604 1 NC_018658.1 COG0191 Fructose/tagatose bisphosphate aldolase; fructose-bisphosphate aldolase 988604 13700638 O3K_04845 Escherichia coli O104:H4 str. 2011C-3493 fructose-bisphosphate aldolase YP_006777689.1 987525 D 1133852 CDS YP_006777690.1 407480541 13700639 988962..989822 1 NC_018658.1 COG0668 Small-conductance mechanosensitive channel; mechanosensitive channel MscS 989822 13700639 O3K_04850 Escherichia coli O104:H4 str. 2011C-3493 mechanosensitive channel MscS YP_006777690.1 988962 D 1133852 CDS YP_006777691.1 407480542 13700640 989961..990596 1 NC_018658.1 COG1279 Lysine efflux permease; arginine exporter protein 990596 13700640 O3K_04855 Escherichia coli O104:H4 str. 2011C-3493 arginine exporter protein YP_006777691.1 989961 D 1133852 CDS YP_006777692.1 407480543 13700641 990689..991429 1 NC_018658.1 COG2968 Uncharacterized conserved protein; oxidative stress defense protein 991429 13700641 O3K_04860 Escherichia coli O104:H4 str. 2011C-3493 oxidative stress defense protein YP_006777692.1 990689 D 1133852 CDS YP_006777693.1 407480544 13700642 991596..992492 1 NC_018658.1 COG0583 Transcriptional regulator; putative DNA-binding transcriptional regulator 992492 13700642 O3K_04865 Escherichia coli O104:H4 str. 2011C-3493 putative DNA-binding transcriptional regulator YP_006777693.1 991596 D 1133852 CDS YP_006777694.1 407480545 13700643 complement(992489..993967) 1 NC_018658.1 COG0427 Acetyl-CoA hydrolase; acetyl-CoA hydrolase 993967 13700643 O3K_04870 Escherichia coli O104:H4 str. 2011C-3493 acetyl-CoA hydrolase YP_006777694.1 992489 R 1133852 CDS YP_006777695.1 407480546 13700644 complement(993991..994776) 1 NC_018658.1 COG1024 Enoyl-CoA hydratase/carnithine racemase; methylmalonyl-CoA decarboxylase 994776 13700644 O3K_04875 Escherichia coli O104:H4 str. 2011C-3493 methylmalonyl-CoA decarboxylase YP_006777695.1 993991 R 1133852 CDS YP_006777696.1 407480547 13700645 complement(994787..995782) 1 NC_018658.1 COG1703 Putative periplasmic protein kinase ArgK and related GTPases of G3E family; membrane ATPase/protein kinase 995782 13700645 O3K_04880 Escherichia coli O104:H4 str. 2011C-3493 membrane ATPase/protein kinase YP_006777696.1 994787 R 1133852 CDS YP_006777697.1 407480548 13700646 complement(995775..997067) 1 NC_018658.1 COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit; methylmalonyl-CoA mutase 997067 13700646 O3K_04885 Escherichia coli O104:H4 str. 2011C-3493 methylmalonyl-CoA mutase YP_006777697.1 995775 R 1133852 CDS YP_006777698.1 407480549 13700647 complement(997191..997919) 1 NC_018658.1 COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit; methylmalonyl-CoA mutase 997919 13700647 O3K_04890 Escherichia coli O104:H4 str. 2011C-3493 methylmalonyl-CoA mutase YP_006777698.1 997191 R 1133852 CDS YP_006777699.1 407480550 13700648 complement(998123..999016) 1 NC_018658.1 COG0583 Transcriptional regulator; chromosome replication initiation inhibitor protein 999016 13700648 O3K_04895 Escherichia coli O104:H4 str. 2011C-3493 chromosome replication initiation inhibitor protein YP_006777699.1 998123 R 1133852 CDS YP_006777700.1 407480551 13700649 999399..1000058 1 NC_018658.1 COG0120 Ribose 5-phosphate isomerase; ribose-5-phosphate isomerase A 1000058 13700649 O3K_04900 Escherichia coli O104:H4 str. 2011C-3493 ribose-5-phosphate isomerase A YP_006777700.1 999399 D 1133852 CDS YP_006777701.1 407480552 13700650 1000314..1001546 1 NC_018658.1 COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; D-3-phosphoglycerate dehydrogenase 1001546 13700650 O3K_04905 Escherichia coli O104:H4 str. 2011C-3493 D-3-phosphoglycerate dehydrogenase YP_006777701.1 1000314 D 1133852 CDS YP_006777702.1 407480553 13700651 complement(1002327..1002875) 1 NC_018658.1 COG0212 5-formyltetrahydrofolate cyclo-ligase; 5-formyltetrahydrofolate cyclo-ligase 1002875 13700651 O3K_04910 Escherichia coli O104:H4 str. 2011C-3493 5-formyltetrahydrofolate cyclo-ligase YP_006777702.1 1002327 R 1133852 CDS YP_006777703.1 407480554 13700652 complement(1003175..1003504) 1 NC_018658.1 COG3027 Uncharacterized protein conserved in bacteria; Z-ring-associated protein 1003504 13700652 O3K_04915 Escherichia coli O104:H4 str. 2011C-3493 Z-ring-associated protein YP_006777703.1 1003175 R 1133852 CDS YP_006777704.1 407480555 13700653 1003672..1004250 1 NC_018658.1 COG3079 Uncharacterized protein conserved in bacteria; hypothetical protein 1004250 13700653 O3K_04920 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777704.1 1003672 D 1133852 CDS YP_006777705.1 407480556 13700654 1004276..1005601 1 NC_018658.1 COG0006 Xaa-Pro aminopeptidase; proline aminopeptidase P II 1005601 13700654 O3K_04925 Escherichia coli O104:H4 str. 2011C-3493 proline aminopeptidase P II YP_006777705.1 1004276 D 1133852 CDS YP_006777706.1 407480557 13700655 1005598..1006776 1 NC_018658.1 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases; 2-octaprenyl-6-methoxyphenyl hydroxylase 1006776 13700655 O3K_04930 Escherichia coli O104:H4 str. 2011C-3493 2-octaprenyl-6-methoxyphenyl hydroxylase YP_006777706.1 1005598 D 1133852 CDS YP_006777707.1 407480558 13700656 1006799..1008001 1 NC_018658.1 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases; oxidoreductase 1008001 13700656 O3K_04935 Escherichia coli O104:H4 str. 2011C-3493 oxidoreductase YP_006777707.1 1006799 D 1133852 CDS YP_006777708.1 407480559 13700657 1008449..1009543 1 NC_018658.1 COG0404 Glycine cleavage system T protein (aminomethyltransferase); glycine cleavage system aminomethyltransferase T 1009543 gcvT 13700657 gcvT Escherichia coli O104:H4 str. 2011C-3493 glycine cleavage system aminomethyltransferase T YP_006777708.1 1008449 D 1133852 CDS YP_006777709.1 407480560 13700658 1009567..1009956 1 NC_018658.1 COG0509 Glycine cleavage system H protein (lipoate-binding); glycine cleavage system protein H 1009956 13700658 O3K_04945 Escherichia coli O104:H4 str. 2011C-3493 glycine cleavage system protein H YP_006777709.1 1009567 D 1133852 CDS YP_006777710.1 407480561 13700659 1010075..1012948 1 NC_018658.1 COG0403 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain; glycine dehydrogenase 1012948 13700659 O3K_04950 Escherichia coli O104:H4 str. 2011C-3493 glycine dehydrogenase YP_006777710.1 1010075 D 1133852 CDS YP_006777711.1 407480562 13700660 1013209..1013952 1 NC_018658.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); putative NAD(P)-binding oxidoreductase 1013952 13700660 O3K_04955 Escherichia coli O104:H4 str. 2011C-3493 putative NAD(P)-binding oxidoreductase YP_006777711.1 1013209 D 1133852 CDS YP_006777712.1 407480563 13700661 complement(1014009..1015442) 1 NC_018658.1 COG2723 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase; 6-phospho-beta-glucosidase 1015442 13700661 O3K_04960 Escherichia coli O104:H4 str. 2011C-3493 6-phospho-beta-glucosidase YP_006777712.1 1014009 R 1133852 CDS YP_006777713.1 407480564 13700662 1015487..1015798 1 NC_018658.1 COG3097 Uncharacterized protein conserved in bacteria; hypothetical protein 1015798 13700662 O3K_04965 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777713.1 1015487 D 1133852 CDS YP_006777714.1 407480565 13700663 1015962..1016621 1 NC_018658.1 COG1272 Predicted membrane protein, hemolysin III homolog; hemolysin 1016621 13700663 O3K_04970 Escherichia coli O104:H4 str. 2011C-3493 hemolysin YP_006777714.1 1015962 D 1133852 CDS YP_006777715.1 407480566 13700664 complement(1016699..1017679) 1 NC_018658.1 COG0354 Predicted aminomethyltransferase related to GcvT; putative global regulator 1017679 13700664 O3K_04975 Escherichia coli O104:H4 str. 2011C-3493 putative global regulator YP_006777715.1 1016699 R 1133852 CDS YP_006777716.1 407480567 13700665 1017922..1018188 1 NC_018658.1 COG2938 Uncharacterized conserved protein; hypothetical protein 1018188 13700665 O3K_04980 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777716.1 1017922 D 1133852 CDS YP_006777717.1 407480568 13700666 1018169..1018576 1 NC_018658.1 hypothetical protein 1018576 13700666 O3K_04985 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777717.1 1018169 D 1133852 CDS YP_006777718.1 407480569 13700667 complement(1018616..1019137) 1 NC_018658.1 COG0716 Flavodoxins; flavodoxin FldB 1019137 13700667 O3K_04990 Escherichia coli O104:H4 str. 2011C-3493 flavodoxin FldB YP_006777718.1 1018616 R 1133852 CDS YP_006777719.1 407480570 13700668 1019249..1020145 1 NC_018658.1 COG4974 Site-specific recombinase XerD; site-specific tyrosine recombinase XerD 1020145 xerD 13700668 xerD Escherichia coli O104:H4 str. 2011C-3493 site-specific tyrosine recombinase XerD YP_006777719.1 1019249 D 1133852 CDS YP_006777720.1 407480571 13700669 1020170..1020880 1 NC_018658.1 COG1651 Protein-disulfide isomerase; protein disulfide isomerase II DsbC 1020880 13700669 O3K_05000 Escherichia coli O104:H4 str. 2011C-3493 protein disulfide isomerase II DsbC YP_006777720.1 1020170 D 1133852 CDS YP_006777721.1 407480572 13700670 1020886..1022619 1 NC_018658.1 COG0608 Single-stranded DNA-specific exonuclease; ssDNA exonuclease RecJ 1022619 13700670 O3K_05005 Escherichia coli O104:H4 str. 2011C-3493 ssDNA exonuclease RecJ YP_006777721.1 1020886 D 1133852 CDS YP_006777722.1 407480573 13700671 1022927..1023808 1 NC_018658.1 COG1186 Protein chain release factor B; peptide chain release factor 2 1023808 prfB 13700671 prfB Escherichia coli O104:H4 str. 2011C-3493 peptide chain release factor 2 YP_006777722.1 1022927 D 1133852 CDS YP_006777723.1 407480574 13700672 1023818..1025335 1 NC_018658.1 COG1190 Lysyl-tRNA synthetase (class II); lysyl-tRNA synthetase 1025335 lysS 13700672 lysS Escherichia coli O104:H4 str. 2011C-3493 lysyl-tRNA synthetase YP_006777723.1 1023818 D 1133852 CDS YP_006777724.1 407480575 13700673 complement(1025378..1025926) 1 NC_018658.1 COG1443 Isopentenyldiphosphate isomerase; isopentenyl-diphosphate delta-isomerase 1025926 13700673 O3K_05020 Escherichia coli O104:H4 str. 2011C-3493 isopentenyl-diphosphate delta-isomerase YP_006777724.1 1025378 R 1133852 CDS YP_006777725.1 407480576 13700674 complement(1026049..1026174) 1 NC_018658.1 hypothetical protein 1026174 13700674 O3K_05025 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777725.1 1026049 R 1133852 CDS YP_006777726.1 407480577 13700675 complement(1026176..1027624) 1 NC_018658.1 COG2233 Xanthine/uracil permeases; transporter 1027624 13700675 O3K_05030 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006777726.1 1026176 R 1133852 CDS YP_006777727.1 407480578 13700676 1028060..1029979 1 NC_018658.1 COG1142 Fe-S-cluster-containing hydrogenase components 2; putative oxidoreductase Fe-S binding subunit 1029979 13700676 O3K_05035 Escherichia coli O104:H4 str. 2011C-3493 putative oxidoreductase Fe-S binding subunit YP_006777727.1 1028060 D 1133852 CDS YP_006777728.1 407480579 13700677 1029979..1030467 1 NC_018658.1 COG1142 Fe-S-cluster-containing hydrogenase components 2; oxidoreductase 1030467 13700677 O3K_05040 Escherichia coli O104:H4 str. 2011C-3493 oxidoreductase YP_006777728.1 1029979 D 1133852 CDS YP_006777729.1 407480580 13700678 complement(1030503..1031870) 1 NC_018658.1 COG2252 Permeases; hypothetical protein 1031870 13700678 O3K_05045 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777729.1 1030503 R 1133852 CDS YP_006777730.1 407480581 13700679 complement(1031906..1033222) 1 NC_018658.1 COG0402 Cytosine deaminase and related metal-dependent hydrolases; guanine deaminase 1033222 13700679 O3K_05050 Escherichia coli O104:H4 str. 2011C-3493 guanine deaminase YP_006777730.1 1031906 R 1133852 CDS YP_006777731.1 407480582 13700680 complement(1033240..1034640) 1 NC_018658.1 COG2233 Xanthine/uracil permeases; transporter 1034640 13700680 O3K_05055 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006777731.1 1033240 R 1133852 CDS YP_006777732.1 407480583 13700681 complement(1034805..1037675) 1 NC_018658.1 COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs; putative hypoxanthine oxidase 1037675 13700681 O3K_05060 Escherichia coli O104:H4 str. 2011C-3493 putative hypoxanthine oxidase YP_006777732.1 1034805 R 1133852 CDS YP_006777733.1 407480584 13700682 complement(1037672..1038451) 1 NC_018658.1 COG1319 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs; oxidoreductase 1038451 13700682 O3K_05065 Escherichia coli O104:H4 str. 2011C-3493 oxidoreductase YP_006777733.1 1037672 R 1133852 CDS YP_006777734.1 407480585 13700683 complement(1038502..1039830) 1 NC_018658.1 COG0402 Cytosine deaminase and related metal-dependent hydrolases; putative chlorohydrolase/aminohydrolase 1039830 13700683 O3K_05070 Escherichia coli O104:H4 str. 2011C-3493 putative chlorohydrolase/aminohydrolase YP_006777734.1 1038502 R 1133852 CDS YP_006777735.1 407480586 13700684 complement(1039833..1042931) 1 NC_018658.1 COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases; putative selenate reductase subunit YgfK 1042931 13700684 O3K_05075 Escherichia coli O104:H4 str. 2011C-3493 putative selenate reductase subunit YgfK YP_006777735.1 1039833 R 1133852 CDS YP_006777736.1 407480587 13700685 complement(1043253..1043831) 1 NC_018658.1 COG2068 Uncharacterized MobA-related protein; hypothetical protein 1043831 13700685 O3K_05080 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777736.1 1043253 R 1133852 CDS YP_006777737.1 407480588 13700686 1043934..1044704 1 NC_018658.1 COG0769 UDP-N-acetylmuramyl tripeptide synthase; hypothetical protein 1044704 13700686 O3K_05085 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777737.1 1043934 D 1133852 CDS YP_006777738.1 407480589 13700687 1044752..1046377 1 NC_018658.1 COG1975 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family; hypothetical protein 1046377 13700687 O3K_05090 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777738.1 1044752 D 1133852 CDS YP_006777739.1 407480590 13700688 complement(1046418..1047350) 1 NC_018658.1 COG0549 Carbamate kinase; putative amino acid kinase 1047350 13700688 O3K_05095 Escherichia coli O104:H4 str. 2011C-3493 putative amino acid kinase YP_006777739.1 1046418 R 1133852 CDS YP_006777740.1 407480591 13700689 complement(1047398..1048783) 1 NC_018658.1 COG0044 Dihydroorotase and related cyclic amidohydrolases; phenylhydantoinase 1048783 13700689 O3K_05100 Escherichia coli O104:H4 str. 2011C-3493 phenylhydantoinase YP_006777740.1 1047398 R 1133852 CDS YP_006777741.1 407480592 13700690 complement(1048836..1050047) 1 NC_018658.1 COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases; peptidase 1050047 13700690 O3K_05105 Escherichia coli O104:H4 str. 2011C-3493 peptidase YP_006777741.1 1048836 R 1133852 CDS YP_006777742.1 407480593 13700691 complement(1050105..1051301) 1 NC_018658.1 COG1171 Threonine dehydratase; diaminopropionate ammonia-lyase 1051301 13700691 O3K_05110 Escherichia coli O104:H4 str. 2011C-3493 diaminopropionate ammonia-lyase YP_006777742.1 1050105 R 1133852 CDS YP_006777743.1 407480594 13700692 complement(1051359..1052546) 1 NC_018658.1 COG0078 Ornithine carbamoyltransferase; aspartate/ornithine carbamoyltransferase family protein 1052546 13700692 O3K_05115 Escherichia coli O104:H4 str. 2011C-3493 aspartate/ornithine carbamoyltransferase family protein YP_006777743.1 1051359 R 1133852 CDS YP_006777744.1 407480595 13700693 1053025..1054803 1 NC_018658.1 COG3829 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains; putative DNA-binding transcriptional regulator 1054803 13700693 O3K_05120 Escherichia coli O104:H4 str. 2011C-3493 putative DNA-binding transcriptional regulator YP_006777744.1 1053025 D 1133852 CDS YP_006777745.1 407480596 13700694 complement(1054843..1055322) 1 NC_018658.1 COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs; xanthine dehydrogenase subunit XdhC 1055322 13700694 O3K_05125 Escherichia coli O104:H4 str. 2011C-3493 xanthine dehydrogenase subunit XdhC YP_006777745.1 1054843 R 1133852 CDS YP_006777746.1 407480597 13700695 complement(1055319..1056197) 1 NC_018658.1 COG1319 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs; xanthine dehydrogenase subunit XdhB 1056197 13700695 O3K_05130 Escherichia coli O104:H4 str. 2011C-3493 xanthine dehydrogenase subunit XdhB YP_006777746.1 1055319 R 1133852 CDS YP_006777747.1 407480598 13700696 complement(1056208..1058505) 1 NC_018658.1 COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs; xanthine dehydrogenase subunit XdhA 1058505 13700696 O3K_05135 Escherichia coli O104:H4 str. 2011C-3493 xanthine dehydrogenase subunit XdhA YP_006777747.1 1056208 R 1133852 CDS YP_006777748.1 407480599 13700697 1058920..1059675 1 NC_018658.1 COG0739 Membrane proteins related to metalloendopeptidases; hypothetical protein 1059675 13700697 O3K_05140 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777748.1 1058920 D 1133852 CDS YP_006777749.1 407480600 13700699 1060019..1061671 1 NC_018658.1 hypothetical protein 1061671 13700699 O3K_05145 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777749.1 1060019 D 1133852 CDS YP_006777750.1 407480601 13700700 1062740..1063405 1 NC_018658.1 COG4790 Type III secretory pathway, component EscR; type III secretion system protein SpaP 1063405 spaP 13700700 spaP Escherichia coli O104:H4 str. 2011C-3493 type III secretion system protein SpaP YP_006777750.1 1062740 D 1133852 CDS YP_006777751.1 407480602 13700701 1063415..1063675 1 NC_018658.1 COG4794 Type III secretory pathway, component EscS; type III secretion protein EpaQ 1063675 13700701 O3K_05165 Escherichia coli O104:H4 str. 2011C-3493 type III secretion protein EpaQ YP_006777751.1 1063415 D 1133852 CDS YP_006777752.1 407480603 13700702 1063677..1064444 1 NC_018658.1 COG4791 Type III secretory pathway, component EscT; type III secretion apparatus protein SpaR/YscT/HrcT 1064444 13700702 O3K_05170 Escherichia coli O104:H4 str. 2011C-3493 type III secretion apparatus protein SpaR/YscT/HrcT YP_006777752.1 1063677 D 1133852 CDS YP_006777753.1 407480604 13700703 1065215..1065607 1 NC_018658.1 COG1377 Flagellar biosynthesis pathway, component FlhB; type III secretion system protein SpaS 1065607 13700703 O3K_05185 Escherichia coli O104:H4 str. 2011C-3493 type III secretion system protein SpaS YP_006777753.1 1065215 D 1133852 CDS YP_006777754.1 407480605 13700704 complement(1065669..1065962) 1 NC_018658.1 hypothetical protein 1065962 13700704 O3K_05190 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777754.1 1065669 R 1133852 CDS YP_006777755.1 407480606 13700705 complement(1065964..1066464) 1 NC_018658.1 response regulator containing a CheY0like receiver domain and an HTH DNA-binding domain; COG2771 DNA-binding HTH domain-containing proteins; putative type III secretion system regulator 1066464 13700705 O3K_05195 Escherichia coli O104:H4 str. 2011C-3493 putative type III secretion system regulator YP_006777755.1 1065964 R 1133852 CDS YP_006777756.1 407480607 13700706 1066722..1067903 1 NC_018658.1 Type III secretion EprH protein 1067903 13700706 O3K_05200 Escherichia coli O104:H4 str. 2011C-3493 Type III secretion EprH protein YP_006777756.1 1066722 D 1133852 CDS YP_006777757.1 407480608 13700707 1067917..1068072 1 NC_018658.1 type III secretion protein EprI 1068072 13700707 O3K_05205 Escherichia coli O104:H4 str. 2011C-3493 type III secretion protein EprI YP_006777757.1 1067917 D 1133852 CDS YP_006777758.1 407480609 13700708 1068249..1068464 1 NC_018658.1 type III secretion protein EprJ 1068464 13700708 O3K_05210 Escherichia coli O104:H4 str. 2011C-3493 type III secretion protein EprJ YP_006777758.1 1068249 D 1133852 CDS YP_006777759.1 407480610 13700709 1068505..1069239 1 NC_018658.1 COG4669 Type III secretory pathway, lipoprotein EscJ; type III secretion system lipoprotein EprK 1069239 13700709 O3K_05215 Escherichia coli O104:H4 str. 2011C-3493 type III secretion system lipoprotein EprK YP_006777759.1 1068505 D 1133852 CDS YP_006777760.1 407480611 13700710 1069255..1069836 1 NC_018658.1 hypothetical protein 1069836 13700710 O3K_05220 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777760.1 1069255 D 1133852 CDS YP_006777761.1 407480612 13700711 1070053..1070484 1 NC_018658.1 hypothetical protein 1070484 13700711 O3K_05225 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777761.1 1070053 D 1133852 CDS YP_006777762.1 407480613 13700712 1070705..1070860 1 NC_018658.1 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; two component LuxR family transcriptional regulator 1070860 13700712 O3K_05230 Escherichia coli O104:H4 str. 2011C-3493 two component LuxR family transcriptional regulator YP_006777762.1 1070705 D 1133852 CDS YP_006777763.1 407480614 13700713 1070894..1071337 1 NC_018658.1 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; hypothetical protein 1071337 13700713 O3K_05235 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777763.1 1070894 D 1133852 CDS YP_006777764.1 407480615 13700714 complement(1071382..1071756) 1 NC_018658.1 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains); peptidoglycan-binding-like protein precursor 1071756 13700714 O3K_05240 Escherichia coli O104:H4 str. 2011C-3493 peptidoglycan-binding-like protein precursor YP_006777764.1 1071382 R 1133852 CDS YP_006777765.1 407480616 13700715 complement(1071941..1072159) 1 NC_018658.1 hypothetical protein 1072159 13700715 O3K_05245 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777765.1 1071941 R 1133852 CDS YP_006777766.1 407480617 13700716 complement(1072327..1073703) 1 NC_018658.1 COG3710 DNA-binding winged-HTH domains; transcriptional regulator 1073703 13700716 O3K_05250 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator YP_006777766.1 1072327 R 1133852 CDS YP_006777767.1 407480618 13700717 complement(1074038..1074529) 1 NC_018658.1 COG0457 FOG: TPR repeat; chaperone 1074529 13700717 O3K_05255 Escherichia coli O104:H4 str. 2011C-3493 chaperone YP_006777767.1 1074038 R 1133852 CDS YP_006777768.1 407480619 13700718 complement(1074807..1075244) 1 NC_018658.1 hypothetical protein 1075244 13700718 O3K_05260 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777768.1 1074807 R 1133852 CDS YP_006777769.1 407480620 13700719 1075899..1075979 1 NC_018658.1 hypothetical protein 1075979 13700719 O3K_05265 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777769.1 1075899 D 1133852 CDS YP_006777770.1 407480621 13700720 complement(1076012..1076494) 1 NC_018658.1 hypothetical protein 1076494 13700720 O3K_05270 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777770.1 1076012 R 1133852 CDS YP_006777771.1 407480622 13700721 complement(1076487..1077296) 1 NC_018658.1 COG3710 DNA-binding winged-HTH domains; transcriptional regulator 1077296 13700721 O3K_05275 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator YP_006777771.1 1076487 R 1133852 CDS YP_006777772.1 407480623 13700722 complement(1077630..1078262) 1 NC_018658.1 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; yqeH protein 1078262 13700722 O3K_05280 Escherichia coli O104:H4 str. 2011C-3493 yqeH protein YP_006777772.1 1077630 R 1133852 CDS YP_006777773.1 407480624 13700723 complement(1078722..1079951) 1 NC_018658.1 COG0814 Amino acid permeases; transporter protein 1079951 13700723 O3K_05285 Escherichia coli O104:H4 str. 2011C-3493 transporter protein YP_006777773.1 1078722 R 1133852 CDS YP_006777774.1 407480625 13700724 1080206..1081387 1 NC_018658.1 COG0183 Acetyl-CoA acetyltransferase; putative acyltransferase 1081387 13700724 O3K_05290 Escherichia coli O104:H4 str. 2011C-3493 putative acyltransferase YP_006777774.1 1080206 D 1133852 CDS YP_006777775.1 407480626 13700725 1081674..1082510 1 NC_018658.1 COG3717 5-keto 4-deoxyuronate isomerase; 5-keto-4-deoxyuronate isomerase 1082510 13700725 O3K_05295 Escherichia coli O104:H4 str. 2011C-3493 5-keto-4-deoxyuronate isomerase YP_006777775.1 1081674 D 1133852 CDS YP_006777776.1 407480627 13700726 1082540..1083301 1 NC_018658.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); 2-deoxy-D-gluconate 3-dehydrogenase 1083301 13700726 O3K_05300 Escherichia coli O104:H4 str. 2011C-3493 2-deoxy-D-gluconate 3-dehydrogenase YP_006777776.1 1082540 D 1133852 CDS YP_006777777.1 407480628 13700727 1083616..1085034 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; sugar transporter 1085034 13700727 O3K_05305 Escherichia coli O104:H4 str. 2011C-3493 sugar transporter YP_006777777.1 1083616 D 1133852 CDS YP_006777778.1 407480629 13700728 1085163..1085855 1 NC_018658.1 COG1794 Aspartate racemase; putative racemase 1085855 13700728 O3K_05310 Escherichia coli O104:H4 str. 2011C-3493 putative racemase YP_006777778.1 1085163 D 1133852 CDS YP_006777779.1 407480630 13700729 complement(1085842..1086777) 1 NC_018658.1 COG0583 Transcriptional regulator; DNA-binding transcriptional regulator LysR 1086777 13700729 O3K_05315 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator LysR YP_006777779.1 1085842 R 1133852 CDS YP_006777780.1 407480631 13700730 1086899..1088161 1 NC_018658.1 COG0019 Diaminopimelate decarboxylase; diaminopimelate decarboxylase 1088161 13700730 O3K_05320 Escherichia coli O104:H4 str. 2011C-3493 diaminopimelate decarboxylase YP_006777780.1 1086899 D 1133852 CDS YP_006777781.1 407480632 13700731 complement(1088168..1089199) 1 NC_018658.1 COG1609 Transcriptional regulators; DNA-binding transcriptional regulator GalR 1089199 13700731 O3K_05325 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator GalR YP_006777781.1 1088168 R 1133852 CDS YP_006777782.1 407480633 13700732 1089785..1091944 1 NC_018658.1 COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase; bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase 1091944 13700732 O3K_05330 Escherichia coli O104:H4 str. 2011C-3493 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase YP_006777782.1 1089785 D 1133852 CDS YP_006777783.1 407480634 13700733 1091937..1093130 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; lysophospholipid transporter LplT 1093130 13700733 O3K_05335 Escherichia coli O104:H4 str. 2011C-3493 lysophospholipid transporter LplT YP_006777783.1 1091937 D 1133852 CDS YP_006777784.1 407480635 13700734 complement(1093162..1094202) 1 NC_018658.1 COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases); putative aldo-keto reductase 1094202 tas 13700734 tas Escherichia coli O104:H4 str. 2011C-3493 putative aldo-keto reductase YP_006777784.1 1093162 R 1133852 CDS YP_006777785.1 407480636 13700735 complement(1094310..1094528) 1 NC_018658.1 COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; hypothetical protein 1094528 13700735 O3K_05345 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777785.1 1094310 R 1133852 CDS YP_006777786.1 407480637 13700736 complement(1094666..1095379) 1 NC_018658.1 COG0861 Membrane protein TerC, possibly involved in tellurium resistance; hypothetical protein 1095379 13700736 O3K_05350 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777786.1 1094666 R 1133852 CDS YP_006777787.1 407480638 13700737 complement(1095448..1096137) 1 NC_018658.1 COG3066 DNA mismatch repair protein; DNA mismatch repair protein 1096137 13700737 O3K_05355 Escherichia coli O104:H4 str. 2011C-3493 DNA mismatch repair protein YP_006777787.1 1095448 R 1133852 CDS YP_006777788.1 407480639 13700738 1096822..1097352 1 NC_018658.1 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; RNA pyrophosphohydrolase 1097352 13700738 O3K_05360 Escherichia coli O104:H4 str. 2011C-3493 RNA pyrophosphohydrolase YP_006777788.1 1096822 D 1133852 CDS YP_006777789.1 407480640 13700739 1097365..1099611 1 NC_018658.1 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; COG3605 Signal transduction protein containing GAF and PtsI domains; PtsP 1099611 13700739 O3K_05365 Escherichia coli O104:H4 str. 2011C-3493 PtsP YP_006777789.1 1097365 D 1133852 CDS YP_006777790.1 407480641 13700740 1099762..1100637 1 NC_018658.1 COG0682 Prolipoprotein diacylglyceryltransferase; prolipoprotein diacylglyceryl transferase 1100637 13700740 O3K_05370 Escherichia coli O104:H4 str. 2011C-3493 prolipoprotein diacylglyceryl transferase YP_006777790.1 1099762 D 1133852 CDS YP_006777791.1 407480642 13700741 1100644..1101438 1 NC_018658.1 COG0207 Thymidylate synthase; thymidylate synthase 1101438 thyA 13700741 thyA Escherichia coli O104:H4 str. 2011C-3493 thymidylate synthase YP_006777791.1 1100644 D 1133852 CDS YP_006777792.1 407480643 13700742 1101623..1102093 1 NC_018658.1 COG2165 Type II secretory pathway, pseudopilin PulG; hypothetical protein 1102093 13700742 O3K_05380 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777792.1 1101623 D 1133852 CDS YP_006777793.1 407480644 13700743 1102084..1102647 1 NC_018658.1 COG4795 Type II secretory pathway, component PulJ; hypothetical protein 1102647 13700743 O3K_05385 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777793.1 1102084 D 1133852 CDS YP_006777794.1 407480645 13700744 1102644..1103051 1 NC_018658.1 hypothetical protein 1103051 13700744 O3K_05390 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777794.1 1102644 D 1133852 CDS YP_006777795.1 407480646 13700745 1103036..1103359 1 NC_018658.1 hypothetical protein 1103359 13700745 O3K_05395 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777795.1 1103036 D 1133852 CDS YP_006777796.1 407480647 13700746 1103372..1106740 1 NC_018658.1 COG1330 Exonuclease V gamma subunit; exonuclease V subunit gamma 1106740 recC 13700746 recC Escherichia coli O104:H4 str. 2011C-3493 exonuclease V subunit gamma YP_006777796.1 1103372 D 1133852 CDS YP_006777797.1 407480648 13700747 1106916..1109804 1 NC_018658.1 COG1025 Secreted/periplasmic Zn-dependent peptidases, insulinase-like; protease3 1109804 13700747 O3K_05405 Escherichia coli O104:H4 str. 2011C-3493 protease3 YP_006777797.1 1106916 D 1133852 CDS YP_006777798.1 407480649 13700748 1109797..1113339 1 NC_018658.1 COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains); exonuclease V subunit beta 1113339 recB 13700748 recB Escherichia coli O104:H4 str. 2011C-3493 exonuclease V subunit beta YP_006777798.1 1109797 D 1133852 CDS YP_006777799.1 407480650 13700749 1113339..1115165 1 NC_018658.1 COG0507 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member; exonuclease V subunit alpha 1115165 recD 13700749 recD Escherichia coli O104:H4 str. 2011C-3493 exonuclease V subunit alpha YP_006777799.1 1113339 D 1133852 CDS YP_006777800.1 407480651 13700750 complement(1115227..1116558) 1 NC_018658.1 COG0548 Acetylglutamate kinase; N-acetylglutamate synthase 1116558 13700750 O3K_05420 Escherichia coli O104:H4 str. 2011C-3493 N-acetylglutamate synthase YP_006777800.1 1115227 R 1133852 CDS YP_006777801.1 407480652 13700751 1116790..1118043 1 NC_018658.1 COG0860 N-acetylmuramoyl-L-alanine amidase; N-acetylmuramoyl-L-alanine amidase 1118043 13700751 O3K_05425 Escherichia coli O104:H4 str. 2011C-3493 N-acetylmuramoyl-L-alanine amidase YP_006777801.1 1116790 D 1133852 CDS YP_006777802.1 407480653 13700753 1118402..1119499 1 NC_018658.1 COG2821 Membrane-bound lytic murein transglycosylase; murein transglycosylase A 1119499 mltA 13700753 mltA Escherichia coli O104:H4 str. 2011C-3493 murein transglycosylase A YP_006777802.1 1118402 D 1133852 CDS YP_006777803.1 407480654 13700754 1119576..1120382 1 NC_018658.1 COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1; sulfur acceptor protein CsdL 1120382 13700754 O3K_05435 Escherichia coli O104:H4 str. 2011C-3493 sulfur acceptor protein CsdL YP_006777803.1 1119576 D 1133852 CDS YP_006777804.1 407480655 13700755 complement(1120433..1120876) 1 NC_018658.1 COG2166 SufE protein probably involved in Fe-S center assembly; CsdA-binding activator 1120876 13700755 O3K_05440 Escherichia coli O104:H4 str. 2011C-3493 CsdA-binding activator YP_006777804.1 1120433 R 1133852 CDS YP_006777805.1 407480656 13700756 complement(1120876..1122081) 1 NC_018658.1 COG0520 Selenocysteine lyase; cysteine sulfinate desulfinase 1122081 13700756 O3K_05445 Escherichia coli O104:H4 str. 2011C-3493 cysteine sulfinate desulfinase YP_006777805.1 1120876 R 1133852 CDS YP_006777806.1 407480657 13700757 1122273..1122500 1 NC_018658.1 hypothetical protein 1122500 13700757 O3K_05450 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777806.1 1122273 D 1133852 CDS YP_006777807.1 407480658 13700758 1122851..1123768 1 NC_018658.1 COG0583 Transcriptional regulator; DNA-binding transcriptional activator GcvA 1123768 13700758 O3K_05455 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional activator GcvA YP_006777807.1 1122851 D 1133852 CDS YP_006777808.1 407480659 13700759 1123787..1124182 1 NC_018658.1 COG2363 Uncharacterized small membrane protein; hypothetical protein 1124182 13700759 O3K_05460 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777808.1 1123787 D 1133852 CDS YP_006777809.1 407480660 13700760 1124175..1125275 1 NC_018658.1 COG2933 Predicted SAM-dependent methyltransferase; putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase 1125275 13700760 O3K_05465 Escherichia coli O104:H4 str. 2011C-3493 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase YP_006777809.1 1124175 D 1133852 CDS YP_006777810.1 407480661 13700761 complement(1125319..1126050) 1 NC_018658.1 COG1349 Transcriptional regulators of sugar metabolism; DNA-binding transcriptional activator FucR 1126050 13700761 O3K_05470 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional activator FucR YP_006777810.1 1125319 R 1133852 CDS YP_006777811.1 407480662 13700762 complement(1126108..1126530) 1 NC_018658.1 COG4154 Fucose dissimilation pathway protein FucU; L-fucose mutarotase 1126530 fucU 13700762 fucU Escherichia coli O104:H4 str. 2011C-3493 L-fucose mutarotase YP_006777811.1 1126108 R 1133852 CDS YP_006777812.1 407480663 13700763 complement(1126532..1127950) 1 NC_018658.1 COG1070 Sugar (pentulose and hexulose) kinases; L-fuculokinase 1127950 13700763 O3K_05480 Escherichia coli O104:H4 str. 2011C-3493 L-fuculokinase YP_006777812.1 1126532 R 1133852 CDS YP_006777813.1 407480664 13700764 complement(1128059..1129834) 1 NC_018658.1 COG2407 L-fucose isomerase and related proteins; L-fucose isomerase 1129834 fucI 13700764 fucI Escherichia coli O104:H4 str. 2011C-3493 L-fucose isomerase YP_006777813.1 1128059 R 1133852 CDS YP_006777814.1 407480665 13700765 complement(1129867..1131183) 1 NC_018658.1 COG0738 Fucose permease; L-fucose transporter 1131183 13700765 O3K_05490 Escherichia coli O104:H4 str. 2011C-3493 L-fucose transporter YP_006777814.1 1129867 R 1133852 CDS YP_006777815.1 407480666 13700766 1131730..1132377 1 NC_018658.1 COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases; L-fuculose phosphate aldolase 1132377 13700766 O3K_05495 Escherichia coli O104:H4 str. 2011C-3493 L-fuculose phosphate aldolase YP_006777815.1 1131730 D 1133852 CDS YP_006777816.1 407480667 13700767 1132405..1133553 1 NC_018658.1 COG1454 Alcohol dehydrogenase, class IV; L-1,2-propanediol oxidoreductase 1133553 13700767 O3K_05500 Escherichia coli O104:H4 str. 2011C-3493 L-1,2-propanediol oxidoreductase YP_006777816.1 1132405 D 1133852 CDS YP_006777817.1 407480668 13700768 complement(1133608..1134453) 1 NC_018658.1 COG0258 5'-3' exonuclease (including N-terminal domain of PolI); flap endonuclease-like protein 1134453 13700768 O3K_05505 Escherichia coli O104:H4 str. 2011C-3493 flap endonuclease-like protein YP_006777817.1 1133608 R 1133852 CDS YP_006777818.1 407480669 13700769 complement(1134475..1135842) 1 NC_018658.1 COG1760 L-serine deaminase; L-serine deaminase II 1135842 13700769 O3K_05510 Escherichia coli O104:H4 str. 2011C-3493 L-serine deaminase II YP_006777818.1 1134475 R 1133852 CDS YP_006777819.1 407480670 13700770 complement(1135900..1137189) 1 NC_018658.1 COG0814 Amino acid permeases; serine transporter 1137189 13700770 O3K_05515 Escherichia coli O104:H4 str. 2011C-3493 serine transporter YP_006777819.1 1135900 R 1133852 CDS YP_006777820.1 407480671 13700771 complement(1137746..1139110) 1 NC_018658.1 COG1611 Predicted Rossmann fold nucleotide-binding protein; hypothetical protein 1139110 13700771 O3K_05520 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777820.1 1137746 R 1133852 CDS YP_006777821.1 407480672 13700772 complement(1139222..1140070) 1 NC_018658.1 COG2904 Uncharacterized protein conserved in bacteria; 7-cyano-7-deazaguanine reductase 1140070 queF 13700772 queF Escherichia coli O104:H4 str. 2011C-3493 7-cyano-7-deazaguanine reductase YP_006777821.1 1139222 R 1133852 CDS YP_006777822.1 407480673 13700773 1140138..1140683 1 NC_018658.1 SecY interacting protein Syd 1140683 13700773 O3K_05530 Escherichia coli O104:H4 str. 2011C-3493 SecY interacting protein Syd YP_006777822.1 1140138 D 1133852 CDS YP_006777823.1 407480674 13700774 1140918..1141058 1 NC_018658.1 hypothetical protein 1141058 13700774 O3K_05535 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777823.1 1140918 D 1133852 CDS YP_006777824.1 407480675 13700775 1141305..1141634 1 NC_018658.1 COG3098 Uncharacterized protein conserved in bacteria; hypothetical protein 1141634 13700775 O3K_05540 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777824.1 1141305 D 1133852 CDS YP_006777825.1 407480676 13700776 1142434..1142883 1 NC_018658.1 COG0716 Flavodoxins; flavodoxin 1142883 13700776 O3K_05555 Escherichia coli O104:H4 str. 2011C-3493 flavodoxin YP_006777825.1 1142434 D 1133852 CDS YP_006777826.1 407480677 13700777 1143318..1144670 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; putative D-glucarate transporter GudP 1144670 13700777 O3K_05560 Escherichia coli O104:H4 str. 2011C-3493 putative D-glucarate transporter GudP YP_006777826.1 1143318 D 1133852 CDS YP_006777827.1 407480678 13700778 1146033..1147373 1 NC_018658.1 COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily; (D)-glucarate dehydratase 1 1147373 13700778 O3K_05575 Escherichia coli O104:H4 str. 2011C-3493 (D)-glucarate dehydratase 1 YP_006777827.1 1146033 D 1133852 CDS YP_006777828.1 407480679 13700779 complement(1147605..1150361) 1 NC_018658.1 COG0642 Signal transduction histidine kinase; hybrid sensory histidine kinase BarA 1150361 13700779 O3K_05580 Escherichia coli O104:H4 str. 2011C-3493 hybrid sensory histidine kinase BarA YP_006777828.1 1147605 R 1133852 CDS YP_006777829.1 407480680 13700780 1150418..1151719 1 NC_018658.1 COG2265 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase; 23S rRNA m(5)U1939 methyltransferase 1151719 rumA 13700780 rumA Escherichia coli O104:H4 str. 2011C-3493 23S rRNA m(5)U1939 methyltransferase YP_006777829.1 1150418 D 1133852 CDS YP_006777830.1 407480681 13700781 1151767..1154001 1 NC_018658.1 COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases; (p)ppGpp synthetase I 1154001 relA 13700781 relA Escherichia coli O104:H4 str. 2011C-3493 (p)ppGpp synthetase I YP_006777830.1 1151767 D 1133852 CDS YP_006777831.1 407480682 13700782 1154079..1154327 1 NC_018658.1 COG2336 Growth regulator; antitoxin MazE 1154327 13700782 O3K_05595 Escherichia coli O104:H4 str. 2011C-3493 antitoxin MazE YP_006777831.1 1154079 D 1133852 CDS YP_006777832.1 407480683 13700783 1154327..1154662 1 NC_018658.1 COG2337 Growth inhibitor; toxin MazF 1154662 13700783 O3K_05600 Escherichia coli O104:H4 str. 2011C-3493 toxin MazF YP_006777832.1 1154327 D 1133852 CDS YP_006777833.1 407480684 13700784 1154733..1155524 1 NC_018658.1 COG1694 Predicted pyrophosphatase; nucleoside triphosphate pyrophosphohydrolase 1155524 mazG 13700784 mazG Escherichia coli O104:H4 str. 2011C-3493 nucleoside triphosphate pyrophosphohydrolase YP_006777833.1 1154733 D 1133852 CDS YP_006777834.1 407480685 13700785 1155752..1157389 1 NC_018658.1 COG0504 CTP synthase (UTP-ammonia lyase); CTP synthetase 1157389 pyrG 13700785 pyrG Escherichia coli O104:H4 str. 2011C-3493 CTP synthetase YP_006777834.1 1155752 D 1133852 CDS YP_006777835.1 407480686 13700786 1157477..1158775 1 NC_018658.1 COG0148 Enolase; enolase 1158775 eno 13700786 eno Escherichia coli O104:H4 str. 2011C-3493 enolase YP_006777835.1 1157477 D 1133852 CDS YP_006777836.1 407480687 13700787 complement(1158759..1158911) 1 NC_018658.1 hypothetical protein 1158911 13700787 O3K_05620 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777836.1 1158759 R 1133852 CDS YP_006777837.1 407480688 13700788 complement(1158835..1159539) 1 NC_018658.1 COG1512 Beta-propeller domains of methanol dehydrogenase type; hypothetical protein 1159539 13700788 O3K_05625 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777837.1 1158835 R 1133852 CDS YP_006777838.1 407480689 13700789 complement(1159721..1159861) 1 NC_018658.1 hypothetical protein 1159861 13700789 O3K_05630 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777838.1 1159721 R 1133852 CDS YP_006777839.1 407480690 13700790 1160000..1160671 1 NC_018658.1 COG0602 Organic radical activating enzymes; hypothetical protein 1160671 13700790 O3K_05635 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777839.1 1160000 D 1133852 CDS YP_006777840.1 407480691 13700791 complement(1161313..1161534) 1 NC_018658.1 hypothetical protein 1161534 13700791 O3K_05640 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777840.1 1161313 R 1133852 CDS YP_006777841.1 407480692 13700792 complement(1162471..1163949) 1 NC_018658.1 COG1070 Sugar (pentulose and hexulose) kinases; kinase 1163949 13700792 O3K_05645 Escherichia coli O104:H4 str. 2011C-3493 kinase YP_006777841.1 1162471 R 1133852 CDS YP_006777842.1 407480693 13700793 complement(1163976..1165253) 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; transporter 1165253 13700793 O3K_05650 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006777842.1 1163976 R 1133852 CDS YP_006777843.1 407480694 13700794 1165572..1166357 1 NC_018658.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); oxidoreductase 1166357 13700794 O3K_05655 Escherichia coli O104:H4 str. 2011C-3493 oxidoreductase YP_006777843.1 1165572 D 1133852 CDS YP_006777844.1 407480695 13700795 1166427..1167881 1 NC_018658.1 COG0277 FAD/FMN-containing dehydrogenases; putative FAD containing dehydrogenase 1167881 13700795 O3K_05660 Escherichia coli O104:H4 str. 2011C-3493 putative FAD containing dehydrogenase YP_006777844.1 1166427 D 1133852 CDS YP_006777845.1 407480696 13700796 1167975..1169312 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; transporter 1169312 13700796 O3K_05665 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006777845.1 1167975 D 1133852 CDS YP_006777846.1 407480697 13700797 1169290..1170069 1 NC_018658.1 COG2086 Electron transfer flavoprotein, beta subunit; putative electron transfer flavoprotein 1170069 13700797 O3K_05670 Escherichia coli O104:H4 str. 2011C-3493 putative electron transfer flavoprotein YP_006777846.1 1169290 D 1133852 CDS YP_006777847.1 407480698 13700798 1170066..1170926 1 NC_018658.1 COG2025 Electron transfer flavoprotein, alpha subunit; flavoprotein 1170926 13700798 O3K_05675 Escherichia coli O104:H4 str. 2011C-3493 flavoprotein YP_006777847.1 1170066 D 1133852 CDS YP_006777848.1 407480699 13700799 complement(1171074..1171649) 1 NC_018658.1 COG1954 Glycerol-3-phosphate responsive antiterminator (mRNA-binding); putative anti-terminator regulatory protein 1171649 13700799 O3K_05680 Escherichia coli O104:H4 str. 2011C-3493 putative anti-terminator regulatory protein YP_006777848.1 1171074 R 1133852 CDS YP_006777849.1 407480700 13700800 complement(1171666..1171926) 1 NC_018658.1 COG2440 Ferredoxin-like protein; 4Fe-4S binding protein 1171926 13700800 O3K_05685 Escherichia coli O104:H4 str. 2011C-3493 4Fe-4S binding protein YP_006777849.1 1171666 R 1133852 CDS YP_006777850.1 407480701 13700801 complement(1171917..1173188) 1 NC_018658.1 COG0644 Dehydrogenases (flavoproteins); oxidoreductase with FAD/NAD(P)-binding domain 1173188 13700801 O3K_05690 Escherichia coli O104:H4 str. 2011C-3493 oxidoreductase with FAD/NAD(P)-binding domain YP_006777850.1 1171917 R 1133852 CDS YP_006777851.1 407480702 13700802 complement(1173266..1173628) 1 NC_018658.1 COG0720 6-pyruvoyl-tetrahydropterin synthase; 6-pyruvoyl tetrahydrobiopterin synthase 1173628 13700802 O3K_05695 Escherichia coli O104:H4 str. 2011C-3493 6-pyruvoyl tetrahydrobiopterin synthase YP_006777851.1 1173266 R 1133852 CDS YP_006777852.1 407480703 13700803 1173947..1175746 1 NC_018658.1 COG0369 Sulfite reductase, alpha subunit (flavoprotein); sulfite reductase subunit alpha 1175746 cysJ 13700803 cysJ Escherichia coli O104:H4 str. 2011C-3493 sulfite reductase subunit alpha YP_006777852.1 1173947 D 1133852 CDS YP_006777853.1 407480704 13700804 1175746..1177458 1 NC_018658.1 COG0155 Sulfite reductase, beta subunit (hemoprotein); sulfite reductase subunit beta 1177458 13700804 O3K_05705 Escherichia coli O104:H4 str. 2011C-3493 sulfite reductase subunit beta YP_006777853.1 1175746 D 1133852 CDS YP_006777854.1 407480705 13700805 1177532..1178266 1 NC_018658.1 COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes; phosphoadenosine phosphosulfate reductase 1178266 13700805 O3K_05710 Escherichia coli O104:H4 str. 2011C-3493 phosphoadenosine phosphosulfate reductase YP_006777854.1 1177532 D 1133852 CDS YP_006777855.1 407480706 13700806 1178531..1178683 1 NC_018658.1 small toxic membrane polypeptide 1178683 13700806 O3K_05715 Escherichia coli O104:H4 str. 2011C-3493 small toxic membrane polypeptide YP_006777855.1 1178531 D 1133852 CDS YP_006777856.1 407480707 13700807 1178760..1179872 1 NC_018658.1 COG3385 FOG: Transposase and inactivated derivatives; putative transposase insL for insertion sequence IS186 1179872 13700807 O3K_05720 Escherichia coli O104:H4 str. 2011C-3493 putative transposase insL for insertion sequence IS186 YP_006777856.1 1178760 D 1133852 CDS YP_006777857.1 407480708 13700808 1180268..1182925 1 NC_018658.1 COG1203 Predicted helicases; hypothetical protein 1182925 13700808 O3K_05725 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777857.1 1180268 D 1133852 CDS YP_006777858.1 407480709 13700809 1183023..1184585 1 NC_018658.1 hypothetical protein 1184585 13700809 O3K_05730 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777858.1 1183023 D 1133852 CDS YP_006777859.1 407480710 13700810 1184582..1185118 1 NC_018658.1 hypothetical protein 1185118 13700810 O3K_05735 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777859.1 1184582 D 1133852 CDS YP_006777860.1 407480711 13700811 1185130..1186185 1 NC_018658.1 hypothetical protein 1186185 13700811 O3K_05740 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777860.1 1185130 D 1133852 CDS YP_006777861.1 407480712 13700812 1186196..1186942 1 NC_018658.1 hypothetical protein 1186942 13700812 O3K_05745 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777861.1 1186196 D 1133852 CDS YP_006777862.1 407480713 13700813 1186924..1187574 1 NC_018658.1 hypothetical protein 1187574 13700813 O3K_05750 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777862.1 1186924 D 1133852 CDS YP_006777863.1 407480714 13700814 1187571..1188491 1 NC_018658.1 COG1518 Uncharacterized protein predicted to be involved in DNA repair; CRISPR-associated protein Cas1 1188491 13700814 O3K_05755 Escherichia coli O104:H4 str. 2011C-3493 CRISPR-associated protein Cas1 YP_006777863.1 1187571 D 1133852 CDS YP_006777864.1 407480715 13700815 1188491..1188784 1 NC_018658.1 putative ssRNA endonuclease 1188784 13700815 O3K_05760 Escherichia coli O104:H4 str. 2011C-3493 putative ssRNA endonuclease YP_006777864.1 1188491 D 1133852 CDS YP_006777865.1 407480716 13700816 complement(1189052..1190089) 1 NC_018658.1 COG2234 Predicted aminopeptidases; alkaline phosphatase isozyme conversion aminopeptidase 1190089 13700816 O3K_05765 Escherichia coli O104:H4 str. 2011C-3493 alkaline phosphatase isozyme conversion aminopeptidase YP_006777865.1 1189052 R 1133852 CDS YP_006777866.1 407480717 13700817 1190341..1191249 1 NC_018658.1 COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes; sulfate adenylyltransferase subunit 2 1191249 13700817 O3K_05770 Escherichia coli O104:H4 str. 2011C-3493 sulfate adenylyltransferase subunit 2 YP_006777866.1 1190341 D 1133852 CDS YP_006777867.1 407480718 13700818 1191251..1192678 1 NC_018658.1 COG2895 GTPases - Sulfate adenylate transferase subunit 1; sulfate adenylyltransferase subunit 1 1192678 cysN 13700818 cysN Escherichia coli O104:H4 str. 2011C-3493 sulfate adenylyltransferase subunit 1 YP_006777867.1 1191251 D 1133852 CDS YP_006777868.1 407480719 13700819 1192678..1193283 1 NC_018658.1 COG0529 Adenylylsulfate kinase and related kinases; adenylylsulfate kinase 1193283 13700819 O3K_05780 Escherichia coli O104:H4 str. 2011C-3493 adenylylsulfate kinase YP_006777868.1 1192678 D 1133852 CDS YP_006777869.1 407480720 13700820 1193333..1193656 1 NC_018658.1 COG0665 Glycine/D-amino acid oxidases (deaminating); hypothetical protein 1193656 13700820 O3K_05785 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777869.1 1193333 D 1133852 CDS YP_006777870.1 407480721 13700821 1193850..1194161 1 NC_018658.1 COG2919 Septum formation initiator; cell division protein FtsB 1194161 ftsB 13700821 ftsB Escherichia coli O104:H4 str. 2011C-3493 cell division protein FtsB YP_006777870.1 1193850 D 1133852 CDS YP_006777871.1 407480722 13700822 1194180..1194890 1 NC_018658.1 COG1211 4-diphosphocytidyl-2-methyl-D-erithritol synthase; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 1194890 ispD 13700822 ispD Escherichia coli O104:H4 str. 2011C-3493 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase YP_006777871.1 1194180 D 1133852 CDS YP_006777872.1 407480723 13700823 1194890..1195369 1 NC_018658.1 COG0245 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; 2-C-methyl-D-erythritol 2,4-cyclo diphosphate synthase 1195369 ispF 13700823 ispF Escherichia coli O104:H4 str. 2011C-3493 2-C-methyl-D-erythritol 2,4-cyclo diphosphate synthase YP_006777872.1 1194890 D 1133852 CDS YP_006777873.1 407480724 13700824 1195366..1196415 1 NC_018658.1 COG0585 Uncharacterized conserved protein; tRNA pseudouridine synthase D 1196415 truD 13700824 truD Escherichia coli O104:H4 str. 2011C-3493 tRNA pseudouridine synthase D YP_006777873.1 1195366 D 1133852 CDS YP_006777874.1 407480725 13700825 1196396..1197157 1 NC_018658.1 COG0496 Predicted acid phosphatase; 5'(3')-nucleotidase/polyphosphatase 1197157 surE 13700825 surE Escherichia coli O104:H4 str. 2011C-3493 5'(3')-nucleotidase/polyphosphatase YP_006777874.1 1196396 D 1133852 CDS YP_006777875.1 407480726 13700826 1197151..1197777 1 NC_018658.1 COG2518 Protein-L-isoaspartate carboxylmethyltransferase; protein-L-isoaspartate O-methyltransferase 1197777 pcm 13700826 pcm Escherichia coli O104:H4 str. 2011C-3493 protein-L-isoaspartate O-methyltransferase YP_006777875.1 1197151 D 1133852 CDS YP_006777876.1 407480727 13700827 1197917..1199056 1 NC_018658.1 COG0739 Membrane proteins related to metalloendopeptidases; lipoprotein NlpD 1199056 nlpD 13700827 nlpD Escherichia coli O104:H4 str. 2011C-3493 lipoprotein NlpD YP_006777876.1 1197917 D 1133852 CDS YP_006777877.1 407480728 13700828 1199119..1200111 1 NC_018658.1 COG0568 DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32); RNA polymerase sigma factor RpoS 1200111 13700828 O3K_05825 Escherichia coli O104:H4 str. 2011C-3493 RNA polymerase sigma factor RpoS YP_006777877.1 1199119 D 1133852 CDS YP_006777878.1 407480729 13700829 complement(1200232..1200639) 1 NC_018658.1 COG1846 Transcriptional regulators; transcriptional regulator hosA 1200639 13700829 O3K_05830 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator hosA YP_006777878.1 1200232 R 1133852 CDS YP_006777879.1 407480730 13700830 1200786..1201379 1 NC_018658.1 COG0163 3-polyprenyl-4-hydroxybenzoate decarboxylase; putative phenylacrylic acid decarboxylase 1201379 13700830 O3K_05835 Escherichia coli O104:H4 str. 2011C-3493 putative phenylacrylic acid decarboxylase YP_006777879.1 1200786 D 1133852 CDS YP_006777880.1 407480731 13700831 1201379..1202806 1 NC_018658.1 COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases; 4-hydroxybenzoate decarboxylase 1202806 13700831 O3K_05840 Escherichia coli O104:H4 str. 2011C-3493 4-hydroxybenzoate decarboxylase YP_006777880.1 1201379 D 1133852 CDS YP_006777881.1 407480732 13700832 1202817..1203053 1 NC_018658.1 non-oxidative reversible hydroxyarylic acid decarboxylase 1203053 13700832 O3K_05845 Escherichia coli O104:H4 str. 2011C-3493 non-oxidative reversible hydroxyarylic acid decarboxylase YP_006777881.1 1202817 D 1133852 CDS YP_006777882.1 407480733 13700833 complement(1203093..1204457) 1 NC_018658.1 COG2610 H+/gluconate symporter and related permeases; transporter 1204457 13700833 O3K_05850 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006777882.1 1203093 R 1133852 CDS YP_006777883.1 407480734 13700834 complement(1204546..1205322) 1 NC_018658.1 COG3622 Hydroxypyruvate isomerase; hypothetical protein 1205322 13700834 O3K_05855 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777883.1 1204546 R 1133852 CDS YP_006777884.1 407480735 13700835 complement(1205327..1205965) 1 NC_018658.1 COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases; putative aldolase 1205965 13700835 O3K_05860 Escherichia coli O104:H4 str. 2011C-3493 putative aldolase YP_006777884.1 1205327 R 1133852 CDS YP_006777885.1 407480736 13700836 complement(1205962..1207224) 1 NC_018658.1 COG3395 Uncharacterized protein conserved in bacteria; hypothetical protein 1207224 13700836 O3K_05865 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777885.1 1205962 R 1133852 CDS YP_006777886.1 407480737 13700837 complement(1207221..1208129) 1 NC_018658.1 COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases; putative dehydrogenase 1208129 13700837 O3K_05870 Escherichia coli O104:H4 str. 2011C-3493 putative dehydrogenase YP_006777886.1 1207221 R 1133852 CDS YP_006777887.1 407480738 13700838 1208325..1209092 1 NC_018658.1 COG1349 Transcriptional regulators of sugar metabolism; DeoR family transcriptional regulator 1209092 13700838 O3K_05875 Escherichia coli O104:H4 str. 2011C-3493 DeoR family transcriptional regulator YP_006777887.1 1208325 D 1133852 CDS YP_006777888.1 407480739 13700839 complement(1209143..1209799) 1 NC_018658.1 COG0639 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases; serine/threonine-specific protein phosphatase 2 1209799 13700839 O3K_05880 Escherichia coli O104:H4 str. 2011C-3493 serine/threonine-specific protein phosphatase 2 YP_006777888.1 1209143 R 1133852 CDS YP_006777889.1 407480740 13700840 complement(1209905..1212466) 1 NC_018658.1 COG0249 Mismatch repair ATPase (MutS family); DNA mismatch repair protein MutS 1212466 13700840 O3K_05885 Escherichia coli O104:H4 str. 2011C-3493 DNA mismatch repair protein MutS YP_006777889.1 1209905 R 1133852 CDS YP_006777890.1 407480741 13700841 1212542..1212721 1 NC_018658.1 hypothetical protein 1212721 13700841 O3K_05890 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777890.1 1212542 D 1133852 CDS YP_006777891.1 407480742 13700842 1212753..1213106 1 NC_018658.1 hypothetical protein 1213106 13700842 O3K_05895 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777891.1 1212753 D 1133852 CDS YP_006777892.1 407480743 13700843 complement(1213143..1215221) 1 NC_018658.1 COG3604 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains; formate hydrogenlyase transcriptional activator FhlA 1215221 13700843 O3K_05900 Escherichia coli O104:H4 str. 2011C-3493 formate hydrogenlyase transcriptional activator FhlA YP_006777892.1 1213143 R 1133852 CDS YP_006777893.1 407480744 13700844 complement(1215295..1216305) 1 NC_018658.1 COG0309 Hydrogenase maturation factor; hydrogenase expression/formation protein HypE 1216305 13700844 O3K_05905 Escherichia coli O104:H4 str. 2011C-3493 hydrogenase expression/formation protein HypE YP_006777893.1 1215295 R 1133852 CDS YP_006777894.1 407480745 13700845 complement(1216302..1217423) 1 NC_018658.1 COG0409 Hydrogenase maturation factor; hydrogenase expression/formation protein HypD 1217423 13700845 O3K_05910 Escherichia coli O104:H4 str. 2011C-3493 hydrogenase expression/formation protein HypD YP_006777894.1 1216302 R 1133852 CDS YP_006777895.1 407480746 13700846 complement(1217423..1217695) 1 NC_018658.1 COG0298 Hydrogenase maturation factor; hydrogenase assembly chaperone 1217695 13700846 O3K_05915 Escherichia coli O104:H4 str. 2011C-3493 hydrogenase assembly chaperone YP_006777895.1 1217423 R 1133852 CDS YP_006777896.1 407480747 13700847 complement(1217686..1218558) 1 NC_018658.1 COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase; hydrogenase nickel incorporation protein HypB 1218558 13700847 O3K_05920 Escherichia coli O104:H4 str. 2011C-3493 hydrogenase nickel incorporation protein HypB YP_006777896.1 1217686 R 1133852 CDS YP_006777897.1 407480748 13700848 complement(1218562..1218912) 1 NC_018658.1 COG0375 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression); hydrogenase nickel incorporation protein 1218912 hypA 13700848 hypA Escherichia coli O104:H4 str. 2011C-3493 hydrogenase nickel incorporation protein YP_006777897.1 1218562 R 1133852 CDS YP_006777898.1 407480749 13700849 1219123..1219584 1 NC_018658.1 formate hydrogenlyase regulatory protein HycA 1219584 13700849 O3K_05930 Escherichia coli O104:H4 str. 2011C-3493 formate hydrogenlyase regulatory protein HycA YP_006777898.1 1219123 D 1133852 CDS YP_006777899.1 407480750 13700850 complement(1219500..1219808) 1 NC_018658.1 hypothetical protein 1219808 13700850 O3K_05935 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777899.1 1219500 R 1133852 CDS YP_006777900.1 407480751 13700851 1219709..1220320 1 NC_018658.1 COG1142 Fe-S-cluster-containing hydrogenase components 2; formate hydrogenlyase subunit B 1220320 13700851 O3K_05940 Escherichia coli O104:H4 str. 2011C-3493 formate hydrogenlyase subunit B YP_006777900.1 1219709 D 1133852 CDS YP_006777901.1 407480752 13700852 1220317..1222143 1 NC_018658.1 COG0651 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit; formate hydrogenlyase subunit 3 1222143 13700852 O3K_05945 Escherichia coli O104:H4 str. 2011C-3493 formate hydrogenlyase subunit 3 YP_006777901.1 1220317 D 1133852 CDS YP_006777902.1 407480753 13700853 1222146..1223069 1 NC_018658.1 COG0650 Formate hydrogenlyase subunit 4; hydrogenase 3, membrane subunit HycD 1223069 13700853 O3K_05950 Escherichia coli O104:H4 str. 2011C-3493 hydrogenase 3, membrane subunit HycD YP_006777902.1 1222146 D 1133852 CDS YP_006777903.1 407480754 13700854 1223087..1224796 1 NC_018658.1 COG3262 Ni,Fe-hydrogenase III component G; formate hydrogenlyase subunit E 1224796 13700854 O3K_05955 Escherichia coli O104:H4 str. 2011C-3493 formate hydrogenlyase subunit E YP_006777903.1 1223087 D 1133852 CDS YP_006777904.1 407480755 13700855 1224806..1225348 1 NC_018658.1 COG1143 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I); formate hydrogenlyase complex iron-sulfur subunit 1225348 13700855 O3K_05960 Escherichia coli O104:H4 str. 2011C-3493 formate hydrogenlyase complex iron-sulfur subunit YP_006777904.1 1224806 D 1133852 CDS YP_006777905.1 407480756 13700856 1225348..1226115 1 NC_018658.1 COG3260 Ni,Fe-hydrogenase III small subunit; hydrogenase 3 and formate hydrogenase complex, HycG subunit 1226115 13700856 O3K_05965 Escherichia coli O104:H4 str. 2011C-3493 hydrogenase 3 and formate hydrogenase complex, HycG subunit YP_006777905.1 1225348 D 1133852 CDS YP_006777906.1 407480757 13700857 1226112..1226522 1 NC_018658.1 formate hydrogenlyase maturation protein HycH 1226522 13700857 O3K_05970 Escherichia coli O104:H4 str. 2011C-3493 formate hydrogenlyase maturation protein HycH YP_006777906.1 1226112 D 1133852 CDS YP_006777907.1 407480758 13700858 1226515..1226985 1 NC_018658.1 COG0680 Ni,Fe-hydrogenase maturation factor; hydrogenase 3 maturation protease 1226985 hycI 13700858 hycI Escherichia coli O104:H4 str. 2011C-3493 hydrogenase 3 maturation protease YP_006777907.1 1226515 D 1133852 CDS YP_006777908.1 407480759 13700859 1227010..1227783 1 NC_018658.1 hypothetical protein 1227783 13700859 O3K_05980 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777908.1 1227010 D 1133852 CDS YP_006777909.1 407480760 13700860 1227854..1228273 1 NC_018658.1 COG5499 Predicted transcription regulator containing HTH domain; HTH-type transcriptional regulator ygjM 1228273 13700860 O3K_05985 Escherichia coli O104:H4 str. 2011C-3493 HTH-type transcriptional regulator ygjM YP_006777909.1 1227854 D 1133852 CDS YP_006777910.1 407480761 13700861 1228518..1229498 1 NC_018658.1 COG3547 Transposase and inactivated derivatives; IS621 transposase 1229498 13700861 O3K_05990 Escherichia coli O104:H4 str. 2011C-3493 IS621 transposase YP_006777910.1 1228518 D 1133852 CDS YP_006777911.1 407480762 13700862 complement(1229666..1231090) 1 NC_018658.1 COG2723 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase; cryptic 6-phospho-beta-glucosidase 1231090 13700862 O3K_05995 Escherichia coli O104:H4 str. 2011C-3493 cryptic 6-phospho-beta-glucosidase YP_006777911.1 1229666 R 1133852 CDS YP_006777912.1 407480763 13700863 complement(1231099..1232556) 1 NC_018658.1 COG1264 Phosphotransferase system IIB components; PTS system cellobiose/arbutin/salicin-specific transporter subunit IIBC 1232556 13700863 O3K_06000 Escherichia coli O104:H4 str. 2011C-3493 PTS system cellobiose/arbutin/salicin-specific transporter subunit IIBC YP_006777912.1 1231099 R 1133852 CDS YP_006777913.1 407480764 13700864 1232813..1233826 1 NC_018658.1 COG1609 Transcriptional regulators; transcriptional regulator 1233826 13700864 O3K_06005 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator YP_006777913.1 1232813 D 1133852 CDS YP_006777914.1 407480765 13700865 1233975..1234502 1 NC_018658.1 COG1142 Fe-S-cluster-containing hydrogenase components 2; formate dehydrogenase-H ferredoxin subunit 1234502 13700865 O3K_06010 Escherichia coli O104:H4 str. 2011C-3493 formate dehydrogenase-H ferredoxin subunit YP_006777914.1 1233975 D 1133852 CDS YP_006777915.1 407480766 13700866 1234655..1236907 1 NC_018658.1 COG0068 Hydrogenase maturation factor; hydrogenase maturation protein 1236907 13700866 O3K_06015 Escherichia coli O104:H4 str. 2011C-3493 hydrogenase maturation protein YP_006777915.1 1234655 D 1133852 CDS YP_006777916.1 407480767 13700867 complement(1237133..1238266) 1 NC_018658.1 COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases; NADH:flavorubredoxin oxidoreductase 1238266 13700867 O3K_06020 Escherichia coli O104:H4 str. 2011C-3493 NADH:flavorubredoxin oxidoreductase YP_006777916.1 1237133 R 1133852 CDS YP_006777917.1 407480768 13702656 complement(1238263..1239702) 1 NC_018658.1 COG0426 Uncharacterized flavoproteins; anaerobic nitric oxide reductase flavorubredoxin 1239702 13702656 O3K_06025 Escherichia coli O104:H4 str. 2011C-3493 anaerobic nitric oxide reductase flavorubredoxin YP_006777917.1 1238263 R 1133852 CDS YP_006777918.1 407480769 13702657 1239889..1241403 1 NC_018658.1 COG3604 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains; anaerobic nitric oxide reductase transcriptional regulator 1241403 13702657 O3K_06030 Escherichia coli O104:H4 str. 2011C-3493 anaerobic nitric oxide reductase transcriptional regulator YP_006777918.1 1239889 D 1133852 CDS YP_006777919.1 407480770 13702658 complement(1241400..1242365) 1 NC_018658.1 COG0794 Predicted sugar phosphate isomerase involved in capsule formation; D-arabinose 5-phosphate isomerase 1242365 gutQ 13702658 gutQ Escherichia coli O104:H4 str. 2011C-3493 D-arabinose 5-phosphate isomerase YP_006777919.1 1241400 R 1133852 CDS YP_006777920.1 407480771 13702659 complement(1242358..1243131) 1 NC_018658.1 COG1349 Transcriptional regulators of sugar metabolism; DNA-binding transcriptional repressor SrlR 1243131 srlR 13702659 srlR Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional repressor SrlR YP_006777920.1 1242358 R 1133852 CDS YP_006777921.1 407480772 13702660 complement(1243198..1243557) 1 NC_018658.1 COG4578 Glucitol operon activator; DNA-binding transcriptional activator GutM 1243557 13702660 O3K_06045 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional activator GutM YP_006777921.1 1243198 R 1133852 CDS YP_006777922.1 407480773 13702661 complement(1243662..1244441) 1 NC_018658.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); sorbitol-6-phosphate dehydrogenase 1244441 13702661 O3K_06050 Escherichia coli O104:H4 str. 2011C-3493 sorbitol-6-phosphate dehydrogenase YP_006777922.1 1243662 R 1133852 CDS YP_006777923.1 407480774 13702662 complement(1244445..1244816) 1 NC_018658.1 COG3731 Phosphotransferase system sorbitol-specific component IIA; PTS system glucitol/sorbitol-specific transporter subunit IIA 1244816 13702662 O3K_06055 Escherichia coli O104:H4 str. 2011C-3493 PTS system glucitol/sorbitol-specific transporter subunit IIA YP_006777923.1 1244445 R 1133852 CDS YP_006777924.1 407480775 13702663 complement(1244827..1245786) 1 NC_018658.1 COG3732 Phosphotransferase system sorbitol-specific component IIBC; PTS system glucitol/sorbitol-specific transporter subunit IIB 1245786 13702663 O3K_06060 Escherichia coli O104:H4 str. 2011C-3493 PTS system glucitol/sorbitol-specific transporter subunit IIB YP_006777924.1 1244827 R 1133852 CDS YP_006777925.1 407480776 13702664 complement(1245783..1246346) 1 NC_018658.1 COG3730 Phosphotransferase system sorbitol-specific component IIC; glucitol/sorbitol permease IIC component 1246346 13702664 O3K_06065 Escherichia coli O104:H4 str. 2011C-3493 glucitol/sorbitol permease IIC component YP_006777925.1 1245783 R 1133852 CDS YP_006777926.1 407480777 13702665 1246602..1247687 1 NC_018658.1 COG2951 Membrane-bound lytic murein transglycosylase B; murein hydrolase B 1247687 13702665 O3K_06070 Escherichia coli O104:H4 str. 2011C-3493 murein hydrolase B YP_006777926.1 1246602 D 1133852 CDS YP_006777927.1 407480778 13702666 1247832..1248329 1 NC_018658.1 COG1546 Uncharacterized protein (competence- and mitomycin-induced); hypothetical protein 1248329 13702666 O3K_06075 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777927.1 1247832 D 1133852 CDS YP_006777928.1 407480779 13702667 1248409..1249470 1 NC_018658.1 COG0468 RecA/RadA recombinase; recombinase A 1249470 recA 13702667 recA Escherichia coli O104:H4 str. 2011C-3493 recombinase A YP_006777928.1 1248409 D 1133852 CDS YP_006777929.1 407480780 13702668 1249713..1250213 1 NC_018658.1 COG2137 Uncharacterized protein conserved in bacteria; recombination regulator RecX 1250213 recX 13702668 recX Escherichia coli O104:H4 str. 2011C-3493 recombination regulator RecX YP_006777929.1 1249713 D 1133852 CDS YP_006777930.1 407480781 13702669 complement(1250254..1250403) 1 NC_018658.1 hypothetical protein 1250403 13702669 O3K_06090 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777930.1 1250254 R 1133852 CDS YP_006777931.1 407480782 13702670 1250341..1252971 1 NC_018658.1 COG0013 Alanyl-tRNA synthetase; alanyl-tRNA synthetase 1252971 alaS 13702670 alaS Escherichia coli O104:H4 str. 2011C-3493 alanyl-tRNA synthetase YP_006777931.1 1250341 D 1133852 CDS YP_006777932.1 407480783 13702671 1253206..1253391 1 NC_018658.1 COG1551 Carbon storage regulator (could also regulate swarming and quorum sensing); carbon storage regulator 1253391 13702671 O3K_06100 Escherichia coli O104:H4 str. 2011C-3493 carbon storage regulator YP_006777932.1 1253206 D 1133852 CDS YP_006777933.1 407480784 13702675 1254433..1254999 1 NC_018658.1 COG0637 Predicted phosphatase/phosphohexomutase; fructose-1-P/6-phosphogluconate phosphatase 1254999 13702675 O3K_06105 Escherichia coli O104:H4 str. 2011C-3493 fructose-1-P/6-phosphogluconate phosphatase YP_006777933.1 1254433 D 1133852 CDS YP_006777934.1 407480785 13702676 1254996..1255424 1 NC_018658.1 COG1238 Predicted membrane protein; hypothetical protein 1255424 13702676 O3K_06110 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777934.1 1254996 D 1133852 CDS YP_006777935.1 407480786 13702677 1255497..1257053 1 NC_018658.1 COG2918 Gamma-glutamylcysteine synthetase; glutamate--cysteine ligase 1257053 13702677 O3K_06115 Escherichia coli O104:H4 str. 2011C-3493 glutamate--cysteine ligase YP_006777935.1 1255497 D 1133852 CDS YP_006777936.1 407480787 13702678 1257203..1257718 1 NC_018658.1 COG1854 LuxS protein involved in autoinducer AI2 synthesis; S-ribosylhomocysteinase 1257718 13702678 O3K_06120 Escherichia coli O104:H4 str. 2011C-3493 S-ribosylhomocysteinase YP_006777936.1 1257203 D 1133852 CDS YP_006777937.1 407480788 13702679 complement(1257782..1259320) 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; membrane translocase 1259320 13702679 O3K_06125 Escherichia coli O104:H4 str. 2011C-3493 membrane translocase YP_006777937.1 1257782 R 1133852 CDS YP_006777938.1 407480789 13702680 complement(1259337..1260509) 1 NC_018658.1 COG1566 Multidrug resistance efflux pump; multidrug efflux system protein EmrA 1260509 13702680 O3K_06130 Escherichia coli O104:H4 str. 2011C-3493 multidrug efflux system protein EmrA YP_006777938.1 1259337 R 1133852 CDS YP_006777939.1 407480790 13702681 complement(1260636..1261166) 1 NC_018658.1 COG1846 Transcriptional regulators; transcriptional repressor MprA 1261166 13702681 O3K_06135 Escherichia coli O104:H4 str. 2011C-3493 transcriptional repressor MprA YP_006777939.1 1260636 R 1133852 CDS YP_006777940.1 407480791 13702682 complement(1261257..1261592) 1 NC_018658.1 putative L-valine exporter 1261592 13702682 O3K_06140 Escherichia coli O104:H4 str. 2011C-3493 putative L-valine exporter YP_006777940.1 1261257 R 1133852 CDS YP_006777941.1 407480792 13702683 complement(1261582..1262319) 1 NC_018658.1 COG1296 Predicted branched-chain amino acid permease (azaleucine resistance); branched chain amino acid exporter (LIV-E) family protein 1262319 13702683 O3K_06145 Escherichia coli O104:H4 str. 2011C-3493 branched chain amino acid exporter (LIV-E) family protein YP_006777941.1 1261582 R 1133852 CDS YP_006777942.1 407480793 13702684 complement(1262443..1263627) 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; transport protein (ousB-like) 1263627 13702684 O3K_06150 Escherichia coli O104:H4 str. 2011C-3493 transport protein (ousB-like) YP_006777942.1 1262443 R 1133852 CDS YP_006777943.1 407480794 13702685 complement(1263819..1264811) 1 NC_018658.1 COG2113 ABC-type proline/glycine betaine transport systems, periplasmic components; glycine betaine transporter periplasmic subunit 1264811 proX 13702685 proX Escherichia coli O104:H4 str. 2011C-3493 glycine betaine transporter periplasmic subunit YP_006777943.1 1263819 R 1133852 CDS YP_006777944.1 407480795 13702686 complement(1264868..1265932) 1 NC_018658.1 COG4176 ABC-type proline/glycine betaine transport system, permease component; glycine betaine transporter membrane protein 1265932 13702686 O3K_06160 Escherichia coli O104:H4 str. 2011C-3493 glycine betaine transporter membrane protein YP_006777944.1 1264868 R 1133852 CDS YP_006777945.1 407480796 13702687 complement(1265925..1267127) 1 NC_018658.1 COG4175 ABC-type proline/glycine betaine transport system, ATPase component; glycine betaine transporter ATP-binding subunit 1267127 13702687 O3K_06165 Escherichia coli O104:H4 str. 2011C-3493 glycine betaine transporter ATP-binding subunit YP_006777945.1 1265925 R 1133852 CDS YP_006777946.1 407480797 13702688 complement(1267482..1268441) 1 NC_018658.1 COG0208 Ribonucleotide reductase, beta subunit; ribonucleotide-diphosphate reductase subunit beta 1268441 nrdF 13702688 nrdF Escherichia coli O104:H4 str. 2011C-3493 ribonucleotide-diphosphate reductase subunit beta YP_006777946.1 1267482 R 1133852 CDS YP_006777947.1 407480798 13702689 complement(1268451..1270595) 1 NC_018658.1 COG0209 Ribonucleotide reductase, alpha subunit; ribonucleotide-diphosphate reductase subunit alpha 1270595 13702689 O3K_06175 Escherichia coli O104:H4 str. 2011C-3493 ribonucleotide-diphosphate reductase subunit alpha YP_006777947.1 1268451 R 1133852 CDS YP_006777948.1 407480799 13702690 complement(1270568..1270978) 1 NC_018658.1 COG1780 Protein involved in ribonucleotide reduction; ribonucleotide reductase stimulatory protein 1270978 nrdI 13702690 nrdI Escherichia coli O104:H4 str. 2011C-3493 ribonucleotide reductase stimulatory protein YP_006777948.1 1270568 R 1133852 CDS YP_006777949.1 407480800 13702691 complement(1270975..1271220) 1 NC_018658.1 COG0695 Glutaredoxin and related proteins; glutaredoxin-like protein 1271220 13702691 O3K_06185 Escherichia coli O104:H4 str. 2011C-3493 glutaredoxin-like protein YP_006777949.1 1270975 R 1133852 CDS YP_006777950.1 407480801 13702692 complement(1271468..1271797) 1 NC_018658.1 COG4575 Uncharacterized conserved protein; hypothetical protein 1271797 13702692 O3K_06190 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777950.1 1271468 R 1133852 CDS YP_006777951.1 407480802 13702693 1271949..1272293 1 NC_018658.1 hypothetical protein 1272293 13702693 O3K_06195 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777951.1 1271949 D 1133852 CDS YP_006777952.1 407480803 13702694 complement(1272330..1272779) 1 NC_018658.1 hypothetical protein 1272779 13702694 O3K_06200 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777952.1 1272330 R 1133852 CDS YP_006777953.1 407480804 13702695 1273447..1273851 1 NC_018658.1 COG2916 DNA-binding protein H-NS; DNA binding protein 1273851 13702695 O3K_06205 Escherichia coli O104:H4 str. 2011C-3493 DNA binding protein YP_006777953.1 1273447 D 1133852 CDS YP_006777954.1 407480805 13702696 complement(1273898..1274422) 1 NC_018658.1 COG0607 Rhodanese-related sulfurtransferase; inner membrane protein 1274422 13702696 O3K_06210 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006777954.1 1273898 R 1133852 CDS YP_006777955.1 407480806 13702697 complement(1274432..1274731) 1 NC_018658.1 COG0640 Predicted transcriptional regulators; putative DNA-binding transcriptional regulator 1274731 13702697 O3K_06215 Escherichia coli O104:H4 str. 2011C-3493 putative DNA-binding transcriptional regulator YP_006777955.1 1274432 R 1133852 CDS YP_006777956.1 407480807 13702698 1274914..1275072 1 NC_018658.1 COG0401 Uncharacterized homolog of Blt101; hypothetical protein 1275072 13702698 O3K_06220 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777956.1 1274914 D 1133852 CDS YP_006777957.1 407480808 13702699 1275156..1275605 1 NC_018658.1 COG1652 Uncharacterized protein containing LysM domain; LysM domain/BON superfamily protein 1275605 13702699 O3K_06225 Escherichia coli O104:H4 str. 2011C-3493 LysM domain/BON superfamily protein YP_006777957.1 1275156 D 1133852 CDS YP_006777958.1 407480809 13702700 complement(1275606..1276268) 1 NC_018658.1 COG1802 Transcriptional regulators; DNA-binding transcriptional regulator CsiR 1276268 13702700 O3K_06230 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator CsiR YP_006777958.1 1275606 R 1133852 CDS YP_006777959.1 407480810 13702701 complement(1276289..1277689) 1 NC_018658.1 COG1113 Gamma-aminobutyrate permease and related permeases; gamma-aminobutyrate transporter 1277689 13702701 O3K_06235 Escherichia coli O104:H4 str. 2011C-3493 gamma-aminobutyrate transporter YP_006777959.1 1276289 R 1133852 CDS YP_006777960.1 407480811 13702702 complement(1278000..1279280) 1 NC_018658.1 COG0160 4-aminobutyrate aminotransferase and related aminotransferases; 4-aminobutyrate aminotransferase 1279280 13702702 O3K_06240 Escherichia coli O104:H4 str. 2011C-3493 4-aminobutyrate aminotransferase YP_006777960.1 1278000 R 1133852 CDS YP_006777961.1 407480812 13702703 complement(1279294..1280742) 1 NC_018658.1 COG1012 NAD-dependent aldehyde dehydrogenases; succinate-semialdehyde dehydrogenase I 1280742 gabD 13702703 gabD Escherichia coli O104:H4 str. 2011C-3493 succinate-semialdehyde dehydrogenase I YP_006777961.1 1279294 R 1133852 CDS YP_006777962.1 407480813 13702704 complement(1280765..1282033) 1 NC_018658.1 COG0579 Predicted dehydrogenase; hydroxyglutarate oxidase 1282033 13702704 O3K_06250 Escherichia coli O104:H4 str. 2011C-3493 hydroxyglutarate oxidase YP_006777962.1 1280765 R 1133852 CDS YP_006777963.1 407480814 13702705 complement(1282053..1283030) 1 NC_018658.1 carbon starvation induced protein 1283030 13702705 O3K_06255 Escherichia coli O104:H4 str. 2011C-3493 carbon starvation induced protein YP_006777963.1 1282053 R 1133852 CDS YP_006777964.1 407480815 13702706 complement(1283366..1283638) 1 NC_018658.1 hypothetical protein 1283638 13702706 O3K_06260 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777964.1 1283366 R 1133852 CDS YP_006777965.1 407480816 13702707 complement(1283973..1285268) 1 NC_018658.1 COG0366 Glycosidases; putative alpha-amylase 1285268 13702707 O3K_06265 Escherichia coli O104:H4 str. 2011C-3493 putative alpha-amylase YP_006777965.1 1283973 R 1133852 CDS YP_006777966.1 407480817 13702709 complement(1289729..1290475) 1 NC_018658.1 COG2801 Transposase and inactivated derivatives; putative IS602 transposase OrfB 1290475 13702709 O3K_06285 Escherichia coli O104:H4 str. 2011C-3493 putative IS602 transposase OrfB YP_006777966.1 1289729 R 1133852 CDS YP_006777967.1 407480818 13702710 complement(1290595..1290942) 1 NC_018658.1 COG2963 Transposase and inactivated derivatives; putative IS602 transposase OrfA 1290942 13702710 O3K_06290 Escherichia coli O104:H4 str. 2011C-3493 putative IS602 transposase OrfA YP_006777967.1 1290595 R 1133852 CDS YP_006777968.1 407480819 13702711 complement(1291428..1291667) 1 NC_018658.1 COG3311 Predicted transcriptional regulator; phage transcriptional regulator AlpA 1291667 13702711 O3K_06300 Escherichia coli O104:H4 str. 2011C-3493 phage transcriptional regulator AlpA YP_006777968.1 1291428 R 1133852 CDS YP_006777969.1 407480820 13702712 1291781..1292662 1 NC_018658.1 hypothetical protein 1292662 13702712 O3K_06305 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777969.1 1291781 D 1133852 CDS YP_006777970.1 407480821 13702713 complement(1292930..1293109) 1 NC_018658.1 hypothetical protein 1293109 13702713 O3K_06310 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777970.1 1292930 R 1133852 CDS YP_006777971.1 407480822 13702714 complement(1293096..1293842) 1 NC_018658.1 hypothetical protein 1293842 13702714 O3K_06315 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777971.1 1293096 R 1133852 CDS YP_006777972.1 407480823 13702715 complement(1293888..1297739) 1 NC_018658.1 COG2925 Exonuclease I; hypothetical protein 1297739 13702715 O3K_06320 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777972.1 1293888 R 1133852 CDS YP_006777973.1 407480824 13702716 1298207..1301953 1 NC_018658.1 hypothetical protein 1301953 13702716 O3K_06325 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777973.1 1298207 D 1133852 CDS YP_006777974.1 407480825 13702717 complement(1302092..1303333) 1 NC_018658.1 COG0582 Integrase; integrase 1303333 13702717 O3K_06330 Escherichia coli O104:H4 str. 2011C-3493 integrase YP_006777974.1 1302092 R 1133852 CDS YP_006777975.1 407480826 13702718 complement(1304116..1304598) 1 NC_018658.1 COG0691 tmRNA-binding protein; SsrA-binding protein 1304598 smpB 13702718 smpB Escherichia coli O104:H4 str. 2011C-3493 SsrA-binding protein YP_006777975.1 1304116 R 1133852 CDS YP_006777976.1 407480827 13702719 1304769..1305206 1 NC_018658.1 COG2867 Oligoketide cyclase/lipid transport protein; hypothetical protein 1305206 13702719 O3K_06340 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777976.1 1304769 D 1133852 CDS YP_006777977.1 407480828 13702720 1305196..1305486 1 NC_018658.1 COG2914 Uncharacterized protein conserved in bacteria; hypothetical protein 1305486 13702720 O3K_06345 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777977.1 1305196 D 1133852 CDS YP_006777978.1 407480829 13702721 complement(1305548..1305889) 1 NC_018658.1 COG2913 Small protein A (tmRNA-binding); outer membrane biogenesis protein BamE 1305889 13702721 O3K_06350 Escherichia coli O104:H4 str. 2011C-3493 outer membrane biogenesis protein BamE YP_006777978.1 1305548 R 1133852 CDS YP_006777979.1 407480830 13702722 complement(1306038..1307699) 1 NC_018658.1 COG0497 ATPase involved in DNA repair; recombination and repair protein 1307699 13702722 O3K_06355 Escherichia coli O104:H4 str. 2011C-3493 recombination and repair protein YP_006777979.1 1306038 R 1133852 CDS YP_006777980.1 407480831 13702723 complement(1307785..1308663) 1 NC_018658.1 COG0061 Predicted sugar kinase; inorganic polyphosphate/ATP-NAD kinase 1308663 13702723 O3K_06360 Escherichia coli O104:H4 str. 2011C-3493 inorganic polyphosphate/ATP-NAD kinase YP_006777980.1 1307785 R 1133852 CDS YP_006777981.1 407480832 13702724 1308786..1309379 1 NC_018658.1 COG0576 Molecular chaperone GrpE (heat shock protein); heat shock protein HSP70 cofactor 1309379 13702724 O3K_06365 Escherichia coli O104:H4 str. 2011C-3493 heat shock protein HSP70 cofactor YP_006777981.1 1308786 D 1133852 CDS YP_006777982.1 407480833 13702725 complement(1309434..1310630) 1 NC_018658.1 COG4536 Putative Mg2+ and Co2+ transporter CorB; hypothetical protein 1310630 13702725 O3K_06370 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777982.1 1309434 R 1133852 CDS YP_006777983.1 407480834 13702726 complement(1310741..1311532) 1 NC_018658.1 COG4137 ABC-type uncharacterized transport system, permease component; hypothetical protein 1311532 13702726 O3K_06375 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777983.1 1310741 R 1133852 CDS YP_006777984.1 407480835 13702727 1311699..1313060 1 NC_018658.1 COG0541 Signal recognition particle GTPase; signal recognition particle protein 1313060 13702727 O3K_06380 Escherichia coli O104:H4 str. 2011C-3493 signal recognition particle protein YP_006777984.1 1311699 D 1133852 CDS YP_006777985.1 407480836 13702728 1313197..1313445 1 NC_018658.1 COG0228 Ribosomal protein S16; 30S ribosomal protein S16 1313445 rpsP 13702728 rpsP Escherichia coli O104:H4 str. 2011C-3493 30S ribosomal protein S16 YP_006777985.1 1313197 D 1133852 CDS YP_006777986.1 407480837 13702729 1313464..1314012 1 NC_018658.1 COG0806 RimM protein, required for 16S rRNA processing; 16S rRNA-processing protein RimM 1314012 rimM 13702729 rimM Escherichia coli O104:H4 str. 2011C-3493 16S rRNA-processing protein RimM YP_006777986.1 1313464 D 1133852 CDS YP_006777987.1 407480838 13702730 1314043..1314810 1 NC_018658.1 COG0336 tRNA-(guanine-N1)-methyltransferase; tRNA (guanine-N(1)-)-methyltransferase 1314810 trmD 13702730 trmD Escherichia coli O104:H4 str. 2011C-3493 tRNA (guanine-N(1)-)-methyltransferase YP_006777987.1 1314043 D 1133852 CDS YP_006777988.1 407480839 13702731 1314852..1315199 1 NC_018658.1 COG0335 Ribosomal protein L19; 50S ribosomal protein L19 1315199 rplS 13702731 rplS Escherichia coli O104:H4 str. 2011C-3493 50S ribosomal protein L19 YP_006777988.1 1314852 D 1133852 CDS YP_006777989.1 407480840 13702732 complement(1315276..1315758) 1 NC_018658.1 COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins; putative outer membrane lipoprotein 1315758 13702732 O3K_06405 Escherichia coli O104:H4 str. 2011C-3493 putative outer membrane lipoprotein YP_006777989.1 1315276 R 1133852 CDS YP_006777990.1 407480841 13702733 complement(1315774..1317000) 1 NC_018658.1 COG2199 FOG: GGDEF domain; putative inner membrane diguanylate cyclase 1317000 13702733 O3K_06410 Escherichia coli O104:H4 str. 2011C-3493 putative inner membrane diguanylate cyclase YP_006777990.1 1315774 R 1133852 CDS YP_006777991.1 407480842 13702734 complement(1316990..1317508) 1 NC_018658.1 hypothetical protein 1317508 13702734 O3K_06415 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777991.1 1316990 R 1133852 CDS YP_006777992.1 407480843 13702735 complement(1317658..1318023) 1 NC_018658.1 COG0178 Excinuclease ATPase subunit; lipoprotein 1318023 13702735 O3K_06420 Escherichia coli O104:H4 str. 2011C-3493 lipoprotein YP_006777992.1 1317658 R 1133852 CDS YP_006777993.1 407480844 13702736 1318233..1319303 1 NC_018658.1 COG0722 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; phospho-2-dehydro-3-deoxyheptonate aldolase 1319303 13702736 O3K_06425 Escherichia coli O104:H4 str. 2011C-3493 phospho-2-dehydro-3-deoxyheptonate aldolase YP_006777993.1 1318233 D 1133852 CDS YP_006777994.1 407480845 13702737 1319314..1320435 1 NC_018658.1 COG1605 Chorismate mutase; bifunctional chorismate mutase/prephenate dehydrogenase 1320435 tyrA 13702737 tyrA Escherichia coli O104:H4 str. 2011C-3493 bifunctional chorismate mutase/prephenate dehydrogenase YP_006777994.1 1319314 D 1133852 CDS YP_006777995.1 407480846 13702738 complement(1320478..1321638) 1 NC_018658.1 COG1605 Chorismate mutase; bifunctional chorismate mutase/prephenate dehydratase 1321638 pheA 13702738 pheA Escherichia coli O104:H4 str. 2011C-3493 bifunctional chorismate mutase/prephenate dehydratase YP_006777995.1 1320478 R 1133852 CDS YP_006777996.1 407480847 13702739 complement(1321888..1322229) 1 NC_018658.1 COG1544 Ribosome-associated protein Y (PSrp-1); translation inhibitor protein RaiA 1322229 13702739 O3K_06440 Escherichia coli O104:H4 str. 2011C-3493 translation inhibitor protein RaiA YP_006777996.1 1321888 R 1133852 CDS YP_006777997.1 407480848 13702740 complement(1322500..1323237) 1 NC_018658.1 COG4105 DNA uptake lipoprotein; outer membrane biogenesis protein BamD 1323237 13702740 O3K_06445 Escherichia coli O104:H4 str. 2011C-3493 outer membrane biogenesis protein BamD YP_006777997.1 1322500 R 1133852 CDS YP_006777998.1 407480849 13702741 1323372..1324352 1 NC_018658.1 COG0564 Pseudouridylate synthases, 23S RNA-specific; 23S rRNA pseudouridine synthase D 1324352 rluD 13702741 rluD Escherichia coli O104:H4 str. 2011C-3493 23S rRNA pseudouridine synthase D YP_006777998.1 1323372 D 1133852 CDS YP_006777999.1 407480850 13702742 1324349..1325080 1 NC_018658.1 COG1496 Uncharacterized conserved protein; hypothetical protein 1325080 13702742 O3K_06455 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006777999.1 1324349 D 1133852 CDS YP_006778000.1 407480851 13702743 1325210..1327783 1 NC_018658.1 COG0542 ATPases with chaperone activity, ATP-binding subunit; protein disaggregation chaperone 1327783 13702743 O3K_06460 Escherichia coli O104:H4 str. 2011C-3493 protein disaggregation chaperone YP_006778000.1 1325210 D 1133852 CDS YP_006778001.1 407480852 13702748 1333649..1334947 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; alpha-ketoglutarate transporter 1334947 13702748 O3K_06465 Escherichia coli O104:H4 str. 2011C-3493 alpha-ketoglutarate transporter YP_006778001.1 1333649 D 1133852 CDS YP_006778002.1 407480853 13702749 complement(1334944..1335267) 1 NC_018658.1 COG5544 Predicted periplasmic lipoprotein; lipoprotein 1335267 13702749 O3K_06470 Escherichia coli O104:H4 str. 2011C-3493 lipoprotein YP_006778002.1 1334944 R 1133852 CDS YP_006778003.1 407480854 13702750 complement(1335313..1336668) 1 NC_018658.1 COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipi n synthases and related enzymes; phosphatidylserine synthase 1336668 pssA 13702750 pssA Escherichia coli O104:H4 str. 2011C-3493 phosphatidylserine synthase YP_006778003.1 1335313 R 1133852 CDS YP_006778004.1 407480855 13702751 complement(1336782..1339442) 1 NC_018658.1 COG1042 Acyl-CoA synthetase (NDP forming); acyl-CoA synthetase NAD(P)-binding subunit/ATP-binding subunit 1339442 13702751 O3K_06480 Escherichia coli O104:H4 str. 2011C-3493 acyl-CoA synthetase NAD(P)-binding subunit/ATP-binding subunit YP_006778004.1 1336782 R 1133852 CDS YP_006778005.1 407480856 13702752 complement(1339474..1340172) 1 NC_018658.1 COG3148 Uncharacterized conserved protein; DTW domain-containing protein yfiP 1340172 13702752 O3K_06485 Escherichia coli O104:H4 str. 2011C-3493 DTW domain-containing protein yfiP YP_006778005.1 1339474 R 1133852 CDS YP_006778006.1 407480857 13702753 complement(1340241..1340660) 1 NC_018658.1 COG0526 Thiol-disulfide isomerase and thioredoxins; thioredoxin 2 1340660 13702753 O3K_06490 Escherichia coli O104:H4 str. 2011C-3493 thioredoxin 2 YP_006778006.1 1340241 R 1133852 CDS YP_006778007.1 407480858 13702754 1340867..1341904 1 NC_018658.1 COG0566 rRNA methylases; methyltransferase 1341904 13702754 O3K_06495 Escherichia coli O104:H4 str. 2011C-3493 methyltransferase YP_006778007.1 1340867 D 1133852 CDS YP_006778008.1 407480859 13702755 complement(1341952..1342641) 1 NC_018658.1 COG0692 Uracil DNA glycosylase; uracil-DNA glycosylase 1342641 13702755 O3K_06500 Escherichia coli O104:H4 str. 2011C-3493 uracil-DNA glycosylase YP_006778008.1 1341952 R 1133852 CDS YP_006778009.1 407480860 13702756 1342946..1343329 1 NC_018658.1 COG3445 Acid-induced glycyl radical enzyme; autonomous glycyl radical cofactor GrcA 1343329 13702756 O3K_06505 Escherichia coli O104:H4 str. 2011C-3493 autonomous glycyl radical cofactor GrcA YP_006778009.1 1342946 D 1133852 CDS YP_006778010.1 407480861 13702757 complement(1343384..1343971) 1 NC_018658.1 COG1280 Putative threonine efflux protein; cysteine/O-acetylserine exporter 1343971 13702757 O3K_06510 Escherichia coli O104:H4 str. 2011C-3493 cysteine/O-acetylserine exporter YP_006778010.1 1343384 R 1133852 CDS YP_006778011.1 407480862 13702758 1344074..1344955 1 NC_018658.1 COG0583 Transcriptional regulator; LysR family transcriptional regulator 1344955 13702758 O3K_06515 Escherichia coli O104:H4 str. 2011C-3493 LysR family transcriptional regulator YP_006778011.1 1344074 D 1133852 CDS YP_006778012.1 407480863 13702759 complement(1345006..1345158) 1 NC_018658.1 hypothetical protein 1345158 13702759 O3K_06520 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778012.1 1345006 R 1133852 CDS YP_006778013.1 407480864 13702760 complement(1345164..1346498) 1 NC_018658.1 COG0513 Superfamily II DNA and RNA helicases; ATP-dependent RNA helicase SrmB 1346498 13702760 O3K_06525 Escherichia coli O104:H4 str. 2011C-3493 ATP-dependent RNA helicase SrmB YP_006778013.1 1345164 R 1133852 CDS YP_006778014.1 407480865 13702761 1346630..1347367 1 NC_018658.1 COG4123 Predicted O-methyltransferase; S-adenosyl-L-methionine-dependent methyltransferase 1347367 13702761 O3K_06530 Escherichia coli O104:H4 str. 2011C-3493 S-adenosyl-L-methionine-dependent methyltransferase YP_006778014.1 1346630 D 1133852 CDS YP_006778015.1 407480866 13702762 complement(1347352..1348974) 1 NC_018658.1 COG0029 Aspartate oxidase; L-aspartate oxidase 1348974 13702762 O3K_06535 Escherichia coli O104:H4 str. 2011C-3493 L-aspartate oxidase YP_006778015.1 1347352 R 1133852 CDS YP_006778016.1 407480867 13702763 1349230..1349385 1 NC_018658.1 hypothetical protein 1349385 13702763 O3K_06540 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778016.1 1349230 D 1133852 CDS YP_006778017.1 407480868 13702764 1349382..1349957 1 NC_018658.1 COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; RNA polymerase sigma factor RpoE 1349957 13702764 O3K_06545 Escherichia coli O104:H4 str. 2011C-3493 RNA polymerase sigma factor RpoE YP_006778017.1 1349382 D 1133852 CDS YP_006778018.1 407480869 13702765 1349990..1350640 1 NC_018658.1 COG3073 Negative regulator of sigma E activity; anti-RNA polymerase sigma factor SigE 1350640 13702765 O3K_06550 Escherichia coli O104:H4 str. 2011C-3493 anti-RNA polymerase sigma factor SigE YP_006778018.1 1349990 D 1133852 CDS YP_006778019.1 407480870 13702766 1350640..1351596 1 NC_018658.1 COG3026 Negative regulator of sigma E activity; anti-sigma E factor 1351596 rseB 13702766 rseB Escherichia coli O104:H4 str. 2011C-3493 anti-sigma E factor YP_006778019.1 1350640 D 1133852 CDS YP_006778020.1 407480871 13702767 1351593..1352072 1 NC_018658.1 COG3086 Positive regulator of sigma E activity; SoxR reducing system protein RseC 1352072 13702767 O3K_06560 Escherichia coli O104:H4 str. 2011C-3493 SoxR reducing system protein RseC YP_006778020.1 1351593 D 1133852 CDS YP_006778021.1 407480872 13702768 1352270..1354069 1 NC_018658.1 COG0481 Membrane GTPase LepA; GTP-binding protein LepA 1354069 13702768 O3K_06565 Escherichia coli O104:H4 str. 2011C-3493 GTP-binding protein LepA YP_006778021.1 1352270 D 1133852 CDS YP_006778022.1 407480873 13702769 1354085..1355059 1 NC_018658.1 COG0681 Signal peptidase I; signal peptidase I 1355059 13702769 O3K_06570 Escherichia coli O104:H4 str. 2011C-3493 signal peptidase I YP_006778022.1 1354085 D 1133852 CDS YP_006778023.1 407480874 13702770 1355332..1356012 1 NC_018658.1 COG0571 dsRNA-specific ribonuclease; ribonuclease III 1356012 rnc 13702770 rnc Escherichia coli O104:H4 str. 2011C-3493 ribonuclease III YP_006778023.1 1355332 D 1133852 CDS YP_006778024.1 407480875 13702771 1356009..1356914 1 NC_018658.1 COG1159 GTPase; GTPase Era 1356914 era 13702771 era Escherichia coli O104:H4 str. 2011C-3493 GTPase Era YP_006778024.1 1356009 D 1133852 CDS YP_006778025.1 407480876 13702772 1356926..1357654 1 NC_018658.1 COG1381 Recombinational DNA repair protein (RecF pathway); DNA repair protein RecO 1357654 recO 13702772 recO Escherichia coli O104:H4 str. 2011C-3493 DNA repair protein RecO YP_006778025.1 1356926 D 1133852 CDS YP_006778026.1 407480877 13702773 1357666..1358397 1 NC_018658.1 COG0854 Pyridoxal phosphate biosynthesis protein; pyridoxine 5'-phosphate synthase 1358397 13702773 O3K_06590 Escherichia coli O104:H4 str. 2011C-3493 pyridoxine 5'-phosphate synthase YP_006778026.1 1357666 D 1133852 CDS YP_006778027.1 407480878 13702774 1358397..1358777 1 NC_018658.1 COG0736 Phosphopantetheinyl transferase (holo-ACP synthase); 4'-phosphopantetheinyl transferase 1358777 acpS 13702774 acpS Escherichia coli O104:H4 str. 2011C-3493 4'-phosphopantetheinyl transferase YP_006778027.1 1358397 D 1133852 CDS YP_006778028.1 407480879 13702775 1359197..1359277 1 NC_018658.1 toxic membrane protein 1359277 13702775 O3K_06600 Escherichia coli O104:H4 str. 2011C-3493 toxic membrane protein YP_006778028.1 1359197 D 1133852 CDS YP_006778029.1 407480880 13702776 complement(1359471..1359731) 1 NC_018658.1 COG1145 Ferredoxin; putative 4Fe-4S cluster-containing protein 1359731 13702776 O3K_06605 Escherichia coli O104:H4 str. 2011C-3493 putative 4Fe-4S cluster-containing protein YP_006778029.1 1359471 R 1133852 CDS YP_006778030.1 407480881 13702777 complement(1359787..1360635) 1 NC_018658.1 COG1737 Transcriptional regulators; putative DNA-binding transcriptional regulator 1360635 13702777 O3K_06610 Escherichia coli O104:H4 str. 2011C-3493 putative DNA-binding transcriptional regulator YP_006778030.1 1359787 R 1133852 CDS YP_006778031.1 407480882 13702778 1360844..1361479 1 NC_018658.1 COG0560 Phosphoserine phosphatase; hypothetical protein 1361479 13702778 O3K_06615 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778031.1 1360844 D 1133852 CDS YP_006778032.1 407480883 13702779 1361504..1362040 1 NC_018658.1 COG0590 Cytosine/adenosine deaminases; tRNA-specific adenosine deaminase 1362040 13702779 O3K_06620 Escherichia coli O104:H4 str. 2011C-3493 tRNA-specific adenosine deaminase YP_006778032.1 1361504 D 1133852 CDS YP_006778033.1 407480884 13702780 complement(1362037..1363593) 1 NC_018658.1 COG4623 Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein; membrane-bound lytic transglycosylase F 1363593 13702780 O3K_06625 Escherichia coli O104:H4 str. 2011C-3493 membrane-bound lytic transglycosylase F YP_006778033.1 1362037 R 1133852 CDS YP_006778034.1 407480885 13702781 1363854..1367738 1 NC_018658.1 COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain; phosphoribosylformylglycinamidine synthase 1367738 13702781 O3K_06630 Escherichia coli O104:H4 str. 2011C-3493 phosphoribosylformylglycinamidine synthase YP_006778034.1 1363854 D 1133852 CDS YP_006778035.1 407480886 13702782 1368314..1369741 1 NC_018658.1 COG0642 Signal transduction histidine kinase; 2-component sensor protein 1369741 13702782 O3K_06635 Escherichia coli O104:H4 str. 2011C-3493 2-component sensor protein YP_006778035.1 1368314 D 1133852 CDS YP_006778036.1 407480887 13702783 1369906..1370619 1 NC_018658.1 hypothetical protein 1370619 13702783 O3K_06640 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778036.1 1369906 D 1133852 CDS YP_006778037.1 407480888 13702784 1370609..1371943 1 NC_018658.1 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains; response regulator GlrR 1371943 13702784 O3K_06645 Escherichia coli O104:H4 str. 2011C-3493 response regulator GlrR YP_006778037.1 1370609 D 1133852 CDS YP_006778038.1 407480889 13702785 1372004..1372342 1 NC_018658.1 COG0347 Nitrogen regulatory protein PII; nitrogen regulatory protein P-II 1 1372342 13702785 O3K_06650 Escherichia coli O104:H4 str. 2011C-3493 nitrogen regulatory protein P-II 1 YP_006778038.1 1372004 D 1133852 CDS YP_006778039.1 407480890 13702786 complement(1372387..1373577) 1 NC_018658.1 COG1017 Hemoglobin-like flavoprotein; bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2 1373577 13702786 O3K_06655 Escherichia coli O104:H4 str. 2011C-3493 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2 YP_006778039.1 1372387 R 1133852 CDS YP_006778040.1 407480891 13702787 1373905..1375158 1 NC_018658.1 COG0112 Glycine/serine hydroxymethyltransferase; serine hydroxymethyltransferase 1375158 glyA 13702787 glyA Escherichia coli O104:H4 str. 2011C-3493 serine hydroxymethyltransferase YP_006778040.1 1373905 D 1133852 CDS YP_006778041.1 407480892 13702788 complement(1375222..1376415) 1 NC_018658.1 COG1940 Transcriptional regulator/sugar kinase; DNA-binding transcriptional regulator 1376415 13702788 O3K_06665 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator YP_006778041.1 1375222 R 1133852 CDS YP_006778042.1 407480893 13702789 1376533..1379814 1 NC_018658.1 COG0457 FOG: TPR repeat; hypothetical protein 1379814 13702789 O3K_06670 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778042.1 1376533 D 1133852 CDS YP_006778043.1 407480894 13702790 1379911..1380894 1 NC_018658.1 COG1879 ABC-type sugar transport system, periplasmic component; sugar ABC transporter substrate-binding protein 1380894 13702790 O3K_06675 Escherichia coli O104:H4 str. 2011C-3493 sugar ABC transporter substrate-binding protein YP_006778043.1 1379911 D 1133852 CDS YP_006778044.1 407480895 13702791 1380917..1382428 1 NC_018658.1 COG1129 ABC-type sugar transport system, ATPase component; sugar ABC transporter ATP-binding protein 1382428 13702791 O3K_06680 Escherichia coli O104:H4 str. 2011C-3493 sugar ABC transporter ATP-binding protein YP_006778044.1 1380917 D 1133852 CDS YP_006778045.1 407480896 13702792 1382453..1383451 1 NC_018658.1 COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components; sugar transporter subunit 1383451 13702792 O3K_06685 Escherichia coli O104:H4 str. 2011C-3493 sugar transporter subunit YP_006778045.1 1382453 D 1133852 CDS YP_006778046.1 407480897 13702793 1383517..1384578 1 NC_018658.1 COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases; oxidoreductase, Zn-dependent and NAD(P)-binding protein 1384578 13702793 O3K_06690 Escherichia coli O104:H4 str. 2011C-3493 oxidoreductase, Zn-dependent and NAD(P)-binding protein YP_006778046.1 1383517 D 1133852 CDS YP_006778047.1 407480898 13702794 1384590..1385462 1 NC_018658.1 COG2017 Galactose mutarotase and related enzymes; hypothetical protein 1385462 13702794 O3K_06695 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778047.1 1384590 D 1133852 CDS YP_006778048.1 407480899 13702795 complement(1385510..1385932) 1 NC_018658.1 COG2259 Predicted membrane protein; inner membrane protein 1385932 13702795 O3K_06700 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006778048.1 1385510 R 1133852 CDS YP_006778049.1 407480900 13702796 complement(1386029..1387231) 1 NC_018658.1 COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases; phenylpropionate dioxygenase ferredoxin reductase subunit 1387231 13702796 O3K_06705 Escherichia coli O104:H4 str. 2011C-3493 phenylpropionate dioxygenase ferredoxin reductase subunit YP_006778049.1 1386029 R 1133852 CDS YP_006778050.1 407480901 13702797 complement(1387241..1388053) 1 NC_018658.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase 1388053 13702797 O3K_06710 Escherichia coli O104:H4 str. 2011C-3493 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase YP_006778050.1 1387241 R 1133852 CDS YP_006778051.1 407480902 13702798 complement(1388050..1388370) 1 NC_018658.1 COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases; 3-phenylpropionate dioxygenase ferredoxin subunit 1388370 13702798 O3K_06715 Escherichia coli O104:H4 str. 2011C-3493 3-phenylpropionate dioxygenase ferredoxin subunit YP_006778051.1 1388050 R 1133852 CDS YP_006778052.1 407480903 13702799 complement(1388370..1388888) 1 NC_018658.1 COG5517 Small subunit of phenylpropionate dioxygenase; 3-phenylpropionate dioxygenase subunit beta 1388888 13702799 O3K_06720 Escherichia coli O104:H4 str. 2011C-3493 3-phenylpropionate dioxygenase subunit beta YP_006778052.1 1388370 R 1133852 CDS YP_006778053.1 407480904 13702800 complement(1388885..1390246) 1 NC_018658.1 COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit; 3-phenylpropionate/cinnamic acid dioxygenase subunit alpha 1390246 13702800 O3K_06725 Escherichia coli O104:H4 str. 2011C-3493 3-phenylpropionate/cinnamic acid dioxygenase subunit alpha YP_006778053.1 1388885 R 1133852 CDS YP_006778054.1 407480905 13702801 1390382..1391272 1 NC_018658.1 COG0583 Transcriptional regulator; DNA-binding transcriptional regulator HcaR 1391272 13702801 O3K_06730 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator HcaR YP_006778054.1 1390382 D 1133852 CDS YP_006778055.1 407480906 13702802 1391432..1392571 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; putative 3-phenylpropionic acid transporter 1392571 13702802 O3K_06735 Escherichia coli O104:H4 str. 2011C-3493 putative 3-phenylpropionic acid transporter YP_006778055.1 1391432 D 1133852 CDS YP_006778056.1 407480907 13702803 complement(1392563..1393843) 1 NC_018658.1 COG3711 Transcriptional antiterminator; stationary phase inducible protein CsiE 1393843 13702803 O3K_06740 Escherichia coli O104:H4 str. 2011C-3493 stationary phase inducible protein CsiE YP_006778056.1 1392563 R 1133852 CDS YP_006778057.1 407480908 13702804 complement(1394034..1394888) 1 NC_018658.1 COG1073 Hydrolases of the alpha/beta superfamily; peptidase 1394888 13702804 O3K_06745 Escherichia coli O104:H4 str. 2011C-3493 peptidase YP_006778057.1 1394034 R 1133852 CDS YP_006778058.1 407480909 13702805 complement(1395033..1395836) 1 NC_018658.1 COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family; inositol monophosphatase 1395836 13702805 O3K_06750 Escherichia coli O104:H4 str. 2011C-3493 inositol monophosphatase YP_006778058.1 1395033 R 1133852 CDS YP_006778059.1 407480910 13702806 1395955..1396695 1 NC_018658.1 COG0565 rRNA methylase; tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ 1396695 13702806 O3K_06755 Escherichia coli O104:H4 str. 2011C-3493 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ YP_006778059.1 1395955 D 1133852 CDS YP_006778060.1 407480911 13702807 1396965..1397453 1 NC_018658.1 COG1959 Predicted transcriptional regulator; DNA-binding transcriptional regulator IscR 1397453 13702807 O3K_06760 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator IscR YP_006778060.1 1396965 D 1133852 CDS YP_006778061.1 407480912 13702808 1397565..1398779 1 NC_018658.1 COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes; cysteine desulfurase 1398779 13702808 O3K_06765 Escherichia coli O104:H4 str. 2011C-3493 cysteine desulfurase YP_006778061.1 1397565 D 1133852 CDS YP_006778062.1 407480913 13702809 1398807..1399193 1 NC_018658.1 COG0822 NifU homolog involved in Fe-S cluster formation; scaffold protein 1399193 13702809 O3K_06770 Escherichia coli O104:H4 str. 2011C-3493 scaffold protein YP_006778062.1 1398807 D 1133852 CDS YP_006778063.1 407480914 13702810 1399210..1399533 1 NC_018658.1 COG0316 Uncharacterized conserved protein; iron-sulfur cluster assembly protein 1399533 iscA 13702810 iscA Escherichia coli O104:H4 str. 2011C-3493 iron-sulfur cluster assembly protein YP_006778063.1 1399210 D 1133852 CDS YP_006778064.1 407480915 13702811 1399629..1400144 1 NC_018658.1 COG1076 DnaJ-domain-containing proteins 1; co-chaperone HscB 1400144 hscB 13702811 hscB Escherichia coli O104:H4 str. 2011C-3493 co-chaperone HscB YP_006778064.1 1399629 D 1133852 CDS YP_006778065.1 407480916 13702812 1400161..1402011 1 NC_018658.1 COG0443 Molecular chaperone; chaperone protein HscA 1402011 hscA 13702812 hscA Escherichia coli O104:H4 str. 2011C-3493 chaperone protein HscA YP_006778065.1 1400161 D 1133852 CDS YP_006778066.1 407480917 13702813 1402013..1402348 1 NC_018658.1 COG0633 Ferredoxin; 2Fe-2S ferredoxin 1402348 13702813 O3K_06790 Escherichia coli O104:H4 str. 2011C-3493 2Fe-2S ferredoxin YP_006778066.1 1402013 D 1133852 CDS YP_006778067.1 407480918 13702814 1402360..1402560 1 NC_018658.1 COG2975 Uncharacterized protein conserved in bacteria; hypothetical protein 1402560 13702814 O3K_06795 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778067.1 1402360 D 1133852 CDS YP_006778068.1 407480919 13702815 1402738..1404021 1 NC_018658.1 COG0260 Leucyl aminopeptidase; aminopeptidase B 1404021 13702815 O3K_06800 Escherichia coli O104:H4 str. 2011C-3493 aminopeptidase B YP_006778068.1 1402738 D 1133852 CDS YP_006778069.1 407480920 13702816 1404163..1404939 1 NC_018658.1 enhanced serine sensitivity protein SseB 1404939 13702816 O3K_06805 Escherichia coli O104:H4 str. 2011C-3493 enhanced serine sensitivity protein SseB YP_006778069.1 1404163 D 1133852 CDS YP_006778070.1 407480921 13702817 complement(1405432..1406277) 1 NC_018658.1 COG2897 Rhodanese-related sulfurtransferase; 3-mercaptopyruvate sulfurtransferase 1406277 sseA 13702817 sseA Escherichia coli O104:H4 str. 2011C-3493 3-mercaptopyruvate sulfurtransferase YP_006778070.1 1405432 R 1133852 CDS YP_006778071.1 407480922 13702818 1406484..1411445 1 NC_018658.1 COG2373 Large extracellular alpha-helical protein; hypothetical protein 1411445 13702818 O3K_06815 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778071.1 1406484 D 1133852 CDS YP_006778072.1 407480923 13702819 1411446..1413758 1 NC_018658.1 COG4953 Membrane carboxypeptidase/penicillin-binding protein PbpC; penicillin-binding protein 1C 1413758 13702819 O3K_06820 Escherichia coli O104:H4 str. 2011C-3493 penicillin-binding protein 1C YP_006778072.1 1411446 D 1133852 CDS YP_006778073.1 407480924 13702820 1413907..1414338 1 NC_018658.1 COG0105 Nucleoside diphosphate kinase; mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-phosphodiesterase 1414338 ndk 13702820 ndk Escherichia coli O104:H4 str. 2011C-3493 mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-phosphodiesterase YP_006778073.1 1413907 D 1133852 CDS YP_006778074.1 407480925 13702821 1414488..1415642 1 NC_018658.1 COG0820 Predicted Fe-S-cluster redox enzyme; ribosomal RNA large subunit methyltransferase N 1415642 13702821 O3K_06830 Escherichia coli O104:H4 str. 2011C-3493 ribosomal RNA large subunit methyltransferase N YP_006778074.1 1414488 D 1133852 CDS YP_006778075.1 407480926 13702822 1415927..1416940 1 NC_018658.1 COG1426 Uncharacterized protein conserved in bacteria; cytoskeletal protein RodZ 1416940 13702822 O3K_06835 Escherichia coli O104:H4 str. 2011C-3493 cytoskeletal protein RodZ YP_006778075.1 1415927 D 1133852 CDS YP_006778076.1 407480927 13702823 1416967..1418085 1 NC_018658.1 COG0821 Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 1418085 ispG 13702823 ispG Escherichia coli O104:H4 str. 2011C-3493 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase YP_006778076.1 1416967 D 1133852 CDS YP_006778077.1 407480928 13702824 1418196..1419470 1 NC_018658.1 COG0124 Histidyl-tRNA synthetase; histidyl-tRNA synthetase 1419470 hisS 13702824 hisS Escherichia coli O104:H4 str. 2011C-3493 histidyl-tRNA synthetase YP_006778077.1 1418196 D 1133852 CDS YP_006778078.1 407480929 13702825 1419488..1420108 1 NC_018658.1 COG2976 Uncharacterized protein conserved in bacteria; hypothetical protein 1420108 13702825 O3K_06850 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778078.1 1419488 D 1133852 CDS YP_006778079.1 407480930 13702826 1420119..1421297 1 NC_018658.1 COG1520 FOG: WD40-like repeat; outer membrane biogenesis protein BamB 1421297 13702826 O3K_06855 Escherichia coli O104:H4 str. 2011C-3493 outer membrane biogenesis protein BamB YP_006778079.1 1420119 D 1133852 CDS YP_006778080.1 407480931 13702827 1421415..1422887 1 NC_018658.1 COG1160 Predicted GTPases; GTP-binding protein Der 1422887 13702827 O3K_06860 Escherichia coli O104:H4 str. 2011C-3493 GTP-binding protein Der YP_006778080.1 1421415 D 1133852 CDS YP_006778081.1 407480932 13702828 1422956..1423171 1 NC_018658.1 COG1933 Archaeal DNA polymerase II, large subunit; hypothetical protein 1423171 13702828 O3K_06865 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778081.1 1422956 D 1133852 CDS YP_006778082.1 407480933 13702829 complement(1423168..1424538) 1 NC_018658.1 COG1570 Exonuclease VII, large subunit; exodeoxyribonuclease VII large subunit 1424538 xseA 13702829 xseA Escherichia coli O104:H4 str. 2011C-3493 exodeoxyribonuclease VII large subunit YP_006778082.1 1423168 R 1133852 CDS YP_006778083.1 407480934 13702830 1424700..1426166 1 NC_018658.1 COG0516 IMP dehydrogenase/GMP reductase; inosine 5'-monophosphate dehydrogenase 1426166 13702830 O3K_06875 Escherichia coli O104:H4 str. 2011C-3493 inosine 5'-monophosphate dehydrogenase YP_006778083.1 1424700 D 1133852 CDS YP_006778084.1 407480935 13702831 1426235..1427812 1 NC_018658.1 COG0518 GMP synthase - Glutamine amidotransferase domain; GMP synthase 1427812 guaA 13702831 guaA Escherichia coli O104:H4 str. 2011C-3493 GMP synthase YP_006778084.1 1426235 D 1133852 CDS YP_006778085.1 407480936 13702832 complement(1427905..1428444) 1 NC_018658.1 hypothetical protein 1428444 13702832 O3K_06885 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778085.1 1427905 R 1133852 CDS YP_006778086.1 407480937 13702833 complement(1428460..1428978) 1 NC_018658.1 putative outer membrane lipoprotein 1428978 13702833 O3K_06890 Escherichia coli O104:H4 str. 2011C-3493 putative outer membrane lipoprotein YP_006778086.1 1428460 R 1133852 CDS YP_006778087.1 407480938 13702834 complement(1429289..1429480) 1 NC_018658.1 hypothetical protein 1429480 13702834 O3K_06895 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778087.1 1429289 R 1133852 CDS YP_006778088.1 407480939 13702835 1429498..1429650 1 NC_018658.1 hypothetical protein 1429650 13702835 O3K_06900 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778088.1 1429498 D 1133852 CDS YP_006778089.1 407480940 13702836 1429832..1432075 1 NC_018658.1 COG2199 FOG: GGDEF domain; inner membrane protein 1432075 13702836 O3K_06905 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006778089.1 1429832 D 1133852 CDS YP_006778090.1 407480941 13702837 complement(1432114..1433655) 1 NC_018658.1 COG0248 Exopolyphosphatase; exopolyphosphatase 1433655 13702837 O3K_06910 Escherichia coli O104:H4 str. 2011C-3493 exopolyphosphatase YP_006778090.1 1432114 R 1133852 CDS YP_006778091.1 407480942 13702838 complement(1433660..1435726) 1 NC_018658.1 COG0855 Polyphosphate kinase; polyphosphate kinase 1435726 13702838 O3K_06915 Escherichia coli O104:H4 str. 2011C-3493 polyphosphate kinase YP_006778091.1 1433660 R 1133852 CDS YP_006778092.1 407480943 13702839 complement(1435897..1436535) 1 NC_018658.1 COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN; phosphoribosylglycinamide formyltransferase 1436535 purN 13702839 purN Escherichia coli O104:H4 str. 2011C-3493 phosphoribosylglycinamide formyltransferase YP_006778092.1 1435897 R 1133852 CDS YP_006778093.1 407480944 13702840 complement(1436535..1437572) 1 NC_018658.1 COG0150 Phosphoribosylaminoimidazole (AIR) synthetase; phosphoribosylaminoimidazole synthetase 1437572 13702840 O3K_06925 Escherichia coli O104:H4 str. 2011C-3493 phosphoribosylaminoimidazole synthetase YP_006778093.1 1436535 R 1133852 CDS YP_006778094.1 407480945 13702841 1437897..1438523 1 NC_018658.1 COG0035 Uracil phosphoribosyltransferase; uracil phosphoribosyltransferase 1438523 upp 13702841 upp Escherichia coli O104:H4 str. 2011C-3493 uracil phosphoribosyltransferase YP_006778094.1 1437897 D 1133852 CDS YP_006778095.1 407480946 13702842 1438609..1439898 1 NC_018658.1 COG2233 Xanthine/uracil permeases; uracil transporter 1439898 13702842 O3K_06935 Escherichia coli O104:H4 str. 2011C-3493 uracil transporter YP_006778095.1 1438609 D 1133852 CDS YP_006778096.1 407480947 13702843 1439948..1440694 1 NC_018658.1 COG0593 ATPase involved in DNA replication initiation; DNA replication initiation factor 1440694 13702843 O3K_06940 Escherichia coli O104:H4 str. 2011C-3493 DNA replication initiation factor YP_006778096.1 1439948 D 1133852 CDS YP_006778097.1 407480948 13702844 complement(1440832..1441191) 1 NC_018658.1 COG1393 Arsenate reductase and related proteins, glutaredoxin family; oxidoreductase 1441191 13702844 O3K_06945 Escherichia coli O104:H4 str. 2011C-3493 oxidoreductase YP_006778097.1 1440832 R 1133852 CDS YP_006778098.1 407480949 13702845 complement(1441212..1442675) 1 NC_018658.1 COG4783 Putative Zn-dependent protease, contains TPR repeats; peptidase, M48 family protein 1442675 13702845 O3K_06950 Escherichia coli O104:H4 str. 2011C-3493 peptidase, M48 family protein YP_006778098.1 1441212 R 1133852 CDS YP_006778099.1 407480950 13702846 1442888..1443949 1 NC_018658.1 COG0628 Predicted permease; permease perM 1443949 13702846 O3K_06955 Escherichia coli O104:H4 str. 2011C-3493 permease perM YP_006778099.1 1442888 D 1133852 CDS YP_006778100.1 407480951 13702847 complement(1444103..1444834) 1 NC_018658.1 COG2116 Formate/nitrite family of transporters; formate transporter 1444834 13702847 O3K_06960 Escherichia coli O104:H4 str. 2011C-3493 formate transporter YP_006778100.1 1444103 R 1133852 CDS YP_006778101.1 407480952 13702848 complement(1444856..1446868) 1 NC_018658.1 COG3604 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains; DNA-binding transcriptional activator, formate sensing 1446868 13702848 O3K_06965 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional activator, formate sensing YP_006778101.1 1444856 R 1133852 CDS YP_006778102.1 407480953 13702849 complement(1446898..1447311) 1 NC_018658.1 formate hydrogenlyase maturation protein HycH 1447311 13702849 O3K_06970 Escherichia coli O104:H4 str. 2011C-3493 formate hydrogenlyase maturation protein HycH YP_006778102.1 1446898 R 1133852 CDS YP_006778103.1 407480954 13702850 complement(1447304..1448062) 1 NC_018658.1 COG3260 Ni,Fe-hydrogenase III small subunit; hydrogenase 4, Fe-S subunit 1448062 13702850 O3K_06975 Escherichia coli O104:H4 str. 2011C-3493 hydrogenase 4, Fe-S subunit YP_006778103.1 1447304 R 1133852 CDS YP_006778104.1 407480955 13702851 complement(1448059..1448598) 1 NC_018658.1 COG1143 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I); hydrogenase 4 subunit H 1448598 13702851 O3K_06980 Escherichia coli O104:H4 str. 2011C-3493 hydrogenase 4 subunit H YP_006778104.1 1448059 R 1133852 CDS YP_006778105.1 407480956 13702852 complement(1448608..1450323) 1 NC_018658.1 COG3262 Ni,Fe-hydrogenase III component G; hydrogenase 4 membrane subunit 1450323 13702852 O3K_06985 Escherichia coli O104:H4 str. 2011C-3493 hydrogenase 4 membrane subunit YP_006778105.1 1448608 R 1133852 CDS YP_006778106.1 407480957 13702853 complement(1450313..1451893) 1 NC_018658.1 COG0651 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit; hydrogenase 4 subunit F 1451893 13702853 O3K_06990 Escherichia coli O104:H4 str. 2011C-3493 hydrogenase 4 subunit F YP_006778106.1 1450313 R 1133852 CDS YP_006778107.1 407480958 13702854 complement(1451898..1452548) 1 NC_018658.1 COG4237 Hydrogenase 4 membrane component (E); hydrogenase 4 membrane subunit 1452548 hyfE 13702854 hyfE Escherichia coli O104:H4 str. 2011C-3493 hydrogenase 4 membrane subunit YP_006778107.1 1451898 R 1133852 CDS YP_006778108.1 407480959 13702855 complement(1452560..1453546) 1 NC_018658.1 COG1009 NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit; hydrogenase 4 subunit D 1453546 13702855 O3K_07000 Escherichia coli O104:H4 str. 2011C-3493 hydrogenase 4 subunit D YP_006778108.1 1452560 R 1133852 CDS YP_006778109.1 407480960 13702856 complement(1453543..1453998) 1 NC_018658.1 COG1009 NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit; putative hydrogenase 4 membrane subunit 1453998 13702856 O3K_07005 Escherichia coli O104:H4 str. 2011C-3493 putative hydrogenase 4 membrane subunit YP_006778109.1 1453543 R 1133852 CDS YP_006778110.1 407480961 13702857 complement(1454015..1454149) 1 NC_018658.1 hydrogenase 4 membrane subunit 1454149 13702857 O3K_07010 Escherichia coli O104:H4 str. 2011C-3493 hydrogenase 4 membrane subunit YP_006778110.1 1454015 R 1133852 CDS YP_006778111.1 407480962 13702858 complement(1454204..1454962) 1 NC_018658.1 COG0650 Formate hydrogenlyase subunit 4; hydrogenase 4 membrane subunit 1454962 13702858 O3K_07015 Escherichia coli O104:H4 str. 2011C-3493 hydrogenase 4 membrane subunit YP_006778111.1 1454204 R 1133852 CDS YP_006778112.1 407480963 13702859 complement(1454973..1456991) 1 NC_018658.1 COG0651 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit; hydrogenase 4 subunit B 1456991 13702859 O3K_07020 Escherichia coli O104:H4 str. 2011C-3493 hydrogenase 4 subunit B YP_006778112.1 1454973 R 1133852 CDS YP_006778113.1 407480964 13702860 complement(1456991..1457608) 1 NC_018658.1 COG1142 Fe-S-cluster-containing hydrogenase components 2; hydrogenase 4, 4Fe-4S subunit 1457608 13702860 O3K_07025 Escherichia coli O104:H4 str. 2011C-3493 hydrogenase 4, 4Fe-4S subunit YP_006778113.1 1456991 R 1133852 CDS YP_006778114.1 407480965 13702861 complement(1457861..1458331) 1 NC_018658.1 COG1225 Peroxiredoxin; thioredoxin-dependent thiol peroxidase 1458331 bcp 13702861 bcp Escherichia coli O104:H4 str. 2011C-3493 thioredoxin-dependent thiol peroxidase YP_006778114.1 1457861 R 1133852 CDS YP_006778115.1 407480966 13702862 complement(1458331..1458903) 1 NC_018658.1 COG2716 Glycine cleavage system regulatory protein; glycine cleavage system transcriptional repressor 1458903 gcvR 13702862 gcvR Escherichia coli O104:H4 str. 2011C-3493 glycine cleavage system transcriptional repressor YP_006778115.1 1458331 R 1133852 CDS YP_006778116.1 407480967 13702863 1459049..1459927 1 NC_018658.1 COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase; dihydrodipicolinate synthase 1459927 13702863 O3K_07040 Escherichia coli O104:H4 str. 2011C-3493 dihydrodipicolinate synthase YP_006778116.1 1459049 D 1133852 CDS YP_006778117.1 407480968 13702864 1459944..1460978 1 NC_018658.1 COG3317 Uncharacterized lipoprotein; lipoprotein 1460978 13702864 O3K_07045 Escherichia coli O104:H4 str. 2011C-3493 lipoprotein YP_006778117.1 1459944 D 1133852 CDS YP_006778118.1 407480969 13702865 complement(1460889..1461140) 1 NC_018658.1 hypothetical protein 1461140 13702865 O3K_07050 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778118.1 1460889 R 1133852 CDS YP_006778119.1 407480970 13702866 1461191..1461904 1 NC_018658.1 COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; phosphoribosylaminoimidazolesuccinocarboxamide synthase 1461904 13702866 O3K_07055 Escherichia coli O104:H4 str. 2011C-3493 phosphoribosylaminoimidazolesuccinocarboxamide synthase YP_006778119.1 1461191 D 1133852 CDS YP_006778120.1 407480971 13702867 1462059..1462286 1 NC_018658.1 COG4456 Virulence-associated protein and related proteins; transcriptional regulation protein 1462286 13702867 O3K_07060 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulation protein YP_006778120.1 1462059 D 1133852 CDS YP_006778121.1 407480972 13702868 1462286..1462684 1 NC_018658.1 COG1487 Predicted nucleic acid-binding protein, contains PIN domain; plasmid maintenance protein 1462684 13702868 O3K_07065 Escherichia coli O104:H4 str. 2011C-3493 plasmid maintenance protein YP_006778121.1 1462286 D 1133852 CDS YP_006778122.1 407480973 13702869 1462831..1463694 1 NC_018658.1 COG2321 Predicted metalloprotease; hypothetical protein 1463694 13702869 O3K_07070 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778122.1 1462831 D 1133852 CDS YP_006778123.1 407480974 13702870 1463709..1465724 1 NC_018658.1 COG1444 Predicted P-loop ATPase fused to an acetyltransferase; hydrolase 1465724 13702870 O3K_07075 Escherichia coli O104:H4 str. 2011C-3493 hydrolase YP_006778123.1 1463709 D 1133852 CDS YP_006778124.1 407480975 13702871 1465798..1466496 1 NC_018658.1 COG0400 Predicted esterase; hydrolase 1466496 13702871 O3K_07080 Escherichia coli O104:H4 str. 2011C-3493 hydrolase YP_006778124.1 1465798 D 1133852 CDS YP_006778125.1 407480976 13702872 complement(1466606..1466806) 1 NC_018658.1 hypothetical protein 1466806 13702872 O3K_07085 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778125.1 1466606 R 1133852 CDS YP_006778126.1 407480977 13702873 complement(1466834..1467961) 1 NC_018658.1 COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases; succinyl-diaminopimelate desuccinylase 1467961 13702873 O3K_07090 Escherichia coli O104:H4 str. 2011C-3493 succinyl-diaminopimelate desuccinylase YP_006778126.1 1466834 R 1133852 CDS YP_006778127.1 407480978 13702874 complement(1467965..1468321) 1 NC_018658.1 COG1393 Arsenate reductase and related proteins, glutaredoxin family; putative reductase 1468321 13702874 O3K_07095 Escherichia coli O104:H4 str. 2011C-3493 putative reductase YP_006778127.1 1467965 R 1133852 CDS YP_006778128.1 407480979 13702875 complement(1468860..1471973) 1 NC_018658.1 COG0841 Cation/multidrug efflux pump; aminoglycoside/multidrug efflux system 1471973 13702875 O3K_07100 Escherichia coli O104:H4 str. 2011C-3493 aminoglycoside/multidrug efflux system YP_006778128.1 1468860 R 1133852 CDS YP_006778129.1 407480980 13702876 complement(1472137..1473837) 1 NC_018658.1 COG3850 Signal transduction histidine kinase, nitrate/nitrite-specific; nitrate/nitrite sensor protein NarQ 1473837 13702876 O3K_07105 Escherichia coli O104:H4 str. 2011C-3493 nitrate/nitrite sensor protein NarQ YP_006778129.1 1472137 R 1133852 CDS YP_006778130.1 407480981 13702877 1474043..1476022 1 NC_018658.1 COG1142 Fe-S-cluster-containing hydrogenase components 2; putative oxidoreductase Fe-S binding subunit 1476022 13702877 O3K_07110 Escherichia coli O104:H4 str. 2011C-3493 putative oxidoreductase Fe-S binding subunit YP_006778130.1 1474043 D 1133852 CDS YP_006778131.1 407480982 13702878 1476090..1476665 1 NC_018658.1 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; GDP-mannose pyrophosphatase NudK 1476665 13702878 O3K_07115 Escherichia coli O104:H4 str. 2011C-3493 GDP-mannose pyrophosphatase NudK YP_006778131.1 1476090 D 1133852 CDS YP_006778132.1 407480983 13702879 1476791..1477834 1 NC_018658.1 COG1088 dTDP-D-glucose 4,6-dehydratase; hypothetical protein 1477834 13702879 O3K_07120 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778132.1 1476791 D 1133852 CDS YP_006778133.1 407480984 13702880 complement(1477930..1479933) 1 NC_018658.1 COG0021 Transketolase; transketolase 1479933 13702880 O3K_07125 Escherichia coli O104:H4 str. 2011C-3493 transketolase YP_006778133.1 1477930 R 1133852 CDS YP_006778134.1 407480985 13702881 complement(1479953..1480903) 1 NC_018658.1 COG0176 Transaldolase; transaldolase A 1480903 13702881 O3K_07130 Escherichia coli O104:H4 str. 2011C-3493 transaldolase A YP_006778134.1 1479953 R 1133852 CDS YP_006778135.1 407480986 13702882 1481192..1483471 1 NC_018658.1 COG0281 Malic enzyme; bifunctional malic enzyme oxidoreductase/phosphotransacetylase 1483471 13702882 O3K_07135 Escherichia coli O104:H4 str. 2011C-3493 bifunctional malic enzyme oxidoreductase/phosphotransacetylase YP_006778135.1 1481192 D 1133852 CDS YP_006778136.1 407480987 13702883 1483764..1484099 1 NC_018658.1 COG4810 Ethanolamine utilization protein; carboxysome structural protein EutS 1484099 13702883 O3K_07140 Escherichia coli O104:H4 str. 2011C-3493 carboxysome structural protein EutS YP_006778136.1 1483764 D 1133852 CDS YP_006778137.1 407480988 13702884 1484112..1484591 1 NC_018658.1 COG4917 Ethanolamine utilization protein; ethanolamine utilization protein EutP 1484591 13702884 O3K_07145 Escherichia coli O104:H4 str. 2011C-3493 ethanolamine utilization protein EutP YP_006778137.1 1484112 D 1133852 CDS YP_006778138.1 407480989 13702885 1484566..1485267 1 NC_018658.1 COG4766 Ethanolamine utilization protein; ethanolamine utilization protein EutQ 1485267 13702885 O3K_07150 Escherichia coli O104:H4 str. 2011C-3493 ethanolamine utilization protein EutQ YP_006778138.1 1484566 D 1133852 CDS YP_006778139.1 407480990 13702886 1485264..1486067 1 NC_018658.1 COG4812 Ethanolamine utilization cobalamin adenosyltransferase; ethanolamine utilization cobalamin adenosyltransferase 1486067 13702886 O3K_07155 Escherichia coli O104:H4 str. 2011C-3493 ethanolamine utilization cobalamin adenosyltransferase YP_006778139.1 1485264 D 1133852 CDS YP_006778140.1 407480991 13702887 1486064..1487080 1 NC_018658.1 COG0280 Phosphotransacetylase; phosphotransacetylase 1487080 eutD 13702887 eutD Escherichia coli O104:H4 str. 2011C-3493 phosphotransacetylase YP_006778140.1 1486064 D 1133852 CDS YP_006778141.1 407480992 13702888 1487119..1487412 1 NC_018658.1 COG4577 Carbon dioxide concentrating mechanism/carboxysome shell protein; carboxysome structural protein EutM 1487412 13702888 O3K_07165 Escherichia coli O104:H4 str. 2011C-3493 carboxysome structural protein EutM YP_006778141.1 1487119 D 1133852 CDS YP_006778142.1 407480993 13702889 1487519..1487806 1 NC_018658.1 COG4576 Carbon dioxide concentrating mechanism/carboxysome shell protein; ethanolamine catabolic microcompartment shell protein EutN 1487806 13702889 O3K_07170 Escherichia coli O104:H4 str. 2011C-3493 ethanolamine catabolic microcompartment shell protein EutN YP_006778142.1 1487519 D 1133852 CDS YP_006778143.1 407480994 13702890 1487818..1489221 1 NC_018658.1 COG1012 NAD-dependent aldehyde dehydrogenases; aldehyde dehydrogenase EutE 1489221 13702890 O3K_07175 Escherichia coli O104:H4 str. 2011C-3493 aldehyde dehydrogenase EutE YP_006778143.1 1487818 D 1133852 CDS YP_006778144.1 407480995 13702891 1489232..1490068 1 NC_018658.1 COG4820 Ethanolamine utilization protein, possible chaperonin; ethanolamine utilization protein EutJ 1490068 13702891 O3K_07180 Escherichia coli O104:H4 str. 2011C-3493 ethanolamine utilization protein EutJ YP_006778144.1 1489232 D 1133852 CDS YP_006778145.1 407480996 13702892 1490058..1491245 1 NC_018658.1 COG1454 Alcohol dehydrogenase, class IV; ethanol dehydrogenase EutG 1491245 13702892 O3K_07185 Escherichia coli O104:H4 str. 2011C-3493 ethanol dehydrogenase EutG YP_006778145.1 1490058 D 1133852 CDS YP_006778146.1 407480997 13702893 1491562..1492788 1 NC_018658.1 COG3192 Ethanolamine utilization protein; ethanolamine utilization protein EutH 1492788 13702893 O3K_07190 Escherichia coli O104:H4 str. 2011C-3493 ethanolamine utilization protein EutH YP_006778146.1 1491562 D 1133852 CDS YP_006778147.1 407480998 13702894 1492785..1494188 1 NC_018658.1 COG4819 Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition; reactivating factor for ethanolamine ammonia lyase 1494188 eutA 13702894 eutA Escherichia coli O104:H4 str. 2011C-3493 reactivating factor for ethanolamine ammonia lyase YP_006778147.1 1492785 D 1133852 CDS YP_006778148.1 407480999 13702895 1494200..1495561 1 NC_018658.1 COG4303 Ethanolamine ammonia-lyase, large subunit; ethanolamine ammonia lyase large subunit 1495561 13702895 O3K_07200 Escherichia coli O104:H4 str. 2011C-3493 ethanolamine ammonia lyase large subunit YP_006778148.1 1494200 D 1133852 CDS YP_006778149.1 407481000 13702896 1495582..1496469 1 NC_018658.1 COG4302 Ethanolamine ammonia-lyase, small subunit; ethanolamine ammonia-lyase small subunit 1496469 13702896 O3K_07205 Escherichia coli O104:H4 str. 2011C-3493 ethanolamine ammonia-lyase small subunit YP_006778149.1 1495582 D 1133852 CDS YP_006778150.1 407481001 13702897 1496479..1497138 1 NC_018658.1 COG4816 Ethanolamine utilization protein; ethanolamine utilization protein EutL 1497138 13702897 O3K_07210 Escherichia coli O104:H4 str. 2011C-3493 ethanolamine utilization protein EutL YP_006778150.1 1496479 D 1133852 CDS YP_006778151.1 407481002 13702898 1497151..1497651 1 NC_018658.1 COG4577 Carbon dioxide concentrating mechanism/carboxysome shell protein; carboxysome structural protein EutK 1497651 13702898 O3K_07215 Escherichia coli O104:H4 str. 2011C-3493 carboxysome structural protein EutK YP_006778151.1 1497151 D 1133852 CDS YP_006778152.1 407481003 13702899 1497697..1498749 1 NC_018658.1 COG2207 AraC-type DNA-binding domain-containing proteins; transcriptional regulator EutR 1498749 13702899 O3K_07220 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator EutR YP_006778152.1 1497697 D 1133852 CDS YP_006778153.1 407481004 13702900 complement(1498755..1499654) 1 NC_018658.1 COG0408 Coproporphyrinogen III oxidase; coproporphyrinogen III oxidase 1499654 13702900 O3K_07225 Escherichia coli O104:H4 str. 2011C-3493 coproporphyrinogen III oxidase YP_006778153.1 1498755 R 1133852 CDS YP_006778154.1 407481005 13702901 complement(1499658..1500527) 1 NC_018658.1 COG0860 N-acetylmuramoyl-L-alanine amidase; N-acetylmuramoyl-l-alanine amidase I 1500527 13702901 O3K_07230 Escherichia coli O104:H4 str. 2011C-3493 N-acetylmuramoyl-l-alanine amidase I YP_006778154.1 1499658 R 1133852 CDS YP_006778155.1 407481006 13702902 1500741..1501166 1 NC_018658.1 COG0456 Acetyltransferases; acetyltransferase 1501166 13702902 O3K_07235 Escherichia coli O104:H4 str. 2011C-3493 acetyltransferase YP_006778155.1 1500741 D 1133852 CDS YP_006778156.1 407481007 13702903 1501153..1501602 1 NC_018658.1 inner membrane protein 1501602 13702903 O3K_07240 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006778156.1 1501153 D 1133852 CDS YP_006778157.1 407481008 13702904 1501663..1502238 1 NC_018658.1 RpoE-regulated lipoprotein 1502238 13702904 O3K_07245 Escherichia coli O104:H4 str. 2011C-3493 RpoE-regulated lipoprotein YP_006778157.1 1501663 D 1133852 CDS YP_006778158.1 407481009 13702905 1502334..1503233 1 NC_018658.1 COG2837 Predicted iron-dependent peroxidase; dyp-type peroxidase family protein 1503233 13702905 O3K_07250 Escherichia coli O104:H4 str. 2011C-3493 dyp-type peroxidase family protein YP_006778158.1 1502334 D 1133852 CDS YP_006778159.1 407481010 13702906 complement(1503289..1504593) 1 NC_018658.1 COG1680 Beta-lactamase class C and other penicillin binding proteins; putative periplasmic esterase 1504593 13702906 O3K_07255 Escherichia coli O104:H4 str. 2011C-3493 putative periplasmic esterase YP_006778159.1 1503289 R 1133852 CDS YP_006778160.1 407481011 13702907 complement(1504598..1506022) 1 NC_018658.1 COG1264 Phosphotransferase system IIB components; PTS system N-acetylmuramic acid transporter subunit IIBC 1506022 murP 13702907 murP Escherichia coli O104:H4 str. 2011C-3493 PTS system N-acetylmuramic acid transporter subunit IIBC YP_006778160.1 1504598 R 1133852 CDS YP_006778161.1 407481012 13702908 complement(1506026..1506922) 1 NC_018658.1 COG2103 Predicted sugar phosphate isomerase; N-acetylmuramic acid 6-phosphate etherase 1506922 murQ 13702908 murQ Escherichia coli O104:H4 str. 2011C-3493 N-acetylmuramic acid 6-phosphate etherase YP_006778161.1 1506026 R 1133852 CDS YP_006778162.1 407481013 13702909 1507086..1507943 1 NC_018658.1 COG1737 Transcriptional regulators; transcriptional regulator MurR 1507943 13702909 O3K_07270 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator MurR YP_006778162.1 1507086 D 1133852 CDS YP_006778163.1 407481014 13702910 1508072..1508863 1 NC_018658.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); short chain dehydrogenase 1508863 13702910 O3K_07275 Escherichia coli O104:H4 str. 2011C-3493 short chain dehydrogenase YP_006778163.1 1508072 D 1133852 CDS YP_006778164.1 407481015 13702911 1509034..1510050 1 NC_018658.1 COG4150 ABC-type sulfate transport system, periplasmic component; thiosulfate transporter subunit 1510050 13702911 O3K_07280 Escherichia coli O104:H4 str. 2011C-3493 thiosulfate transporter subunit YP_006778164.1 1509034 D 1133852 CDS YP_006778165.1 407481016 13702912 1510050..1510883 1 NC_018658.1 COG0555 ABC-type sulfate transport system, permease component; sulfate/thiosulfate transporter subunit 1510883 13702912 O3K_07285 Escherichia coli O104:H4 str. 2011C-3493 sulfate/thiosulfate transporter subunit YP_006778165.1 1510050 D 1133852 CDS YP_006778166.1 407481017 13702913 1510883..1511758 1 NC_018658.1 COG4208 ABC-type sulfate transport system, permease component; sulfate/thiosulfate transporter permease subunit 1511758 cysW 13702913 cysW Escherichia coli O104:H4 str. 2011C-3493 sulfate/thiosulfate transporter permease subunit YP_006778166.1 1510883 D 1133852 CDS YP_006778167.1 407481018 13702914 1511748..1512845 1 NC_018658.1 COG1118 ABC-type sulfate/molybdate transport systems, ATPase component; sulfate/thiosulfate transporter subunit 1512845 13702914 O3K_07295 Escherichia coli O104:H4 str. 2011C-3493 sulfate/thiosulfate transporter subunit YP_006778167.1 1511748 D 1133852 CDS YP_006778168.1 407481019 13702915 1512979..1513890 1 NC_018658.1 COG0031 Cysteine synthase; cysteine synthase B 1513890 cysM 13702915 cysM Escherichia coli O104:H4 str. 2011C-3493 cysteine synthase B YP_006778168.1 1512979 D 1133852 CDS YP_006778169.1 407481020 13702916 complement(1513893..1514261) 1 NC_018658.1 hypothetical protein 1514261 13702916 O3K_07305 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778169.1 1513893 R 1133852 CDS YP_006778170.1 407481021 13702917 1514366..1515217 1 NC_018658.1 COG2240 Pyridoxal/pyridoxine/pyridoxamine kinase; pyridoxal-pyridoxamine kinase/hydroxymethylpyrimidine kinase 1515217 pdxK 13702917 pdxK Escherichia coli O104:H4 str. 2011C-3493 pyridoxal-pyridoxamine kinase/hydroxymethylpyrimidine kinase YP_006778170.1 1514366 D 1133852 CDS YP_006778171.1 407481022 13702918 complement(1515259..1515768) 1 NC_018658.1 COG2190 Phosphotransferase system IIA components; PTS system glucose-specific transporter 1515768 13702918 O3K_07315 Escherichia coli O104:H4 str. 2011C-3493 PTS system glucose-specific transporter YP_006778171.1 1515259 R 1133852 CDS YP_006778172.1 407481023 13702919 complement(1515809..1517536) 1 NC_018658.1 COG1080 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria); phosphoenolpyruvate-protein phosphotransferase 1517536 13702919 O3K_07320 Escherichia coli O104:H4 str. 2011C-3493 phosphoenolpyruvate-protein phosphotransferase YP_006778172.1 1515809 R 1133852 CDS YP_006778173.1 407481024 13702920 complement(1517581..1517838) 1 NC_018658.1 COG1925 Phosphotransferase system, HPr-related proteins; PTS system phosphohistidinoprotein-hexose phosphotransferase Hpr 1517838 13702920 O3K_07325 Escherichia coli O104:H4 str. 2011C-3493 PTS system phosphohistidinoprotein-hexose phosphotransferase Hpr YP_006778173.1 1517581 R 1133852 CDS YP_006778174.1 407481025 13702921 complement(1518222..1519193) 1 NC_018658.1 COG0031 Cysteine synthase; cysteine synthase A 1519193 13702921 O3K_07330 Escherichia coli O104:H4 str. 2011C-3493 cysteine synthase A YP_006778174.1 1518222 R 1133852 CDS YP_006778175.1 407481026 13702922 complement(1519378..1520139) 1 NC_018658.1 COG2981 Uncharacterized protein involved in cysteine biosynthesis; putative sulfate transport protein CysZ 1520139 13702922 O3K_07335 Escherichia coli O104:H4 str. 2011C-3493 putative sulfate transport protein CysZ YP_006778175.1 1519378 R 1133852 CDS YP_006778176.1 407481027 13702923 1520369..1521355 1 NC_018658.1 COG3115 Cell division protein; cell division protein ZipA 1521355 13702923 O3K_07340 Escherichia coli O104:H4 str. 2011C-3493 cell division protein ZipA YP_006778176.1 1520369 D 1133852 CDS YP_006778177.1 407481028 13702924 1521426..1523441 1 NC_018658.1 COG0272 NAD-dependent DNA ligase (contains BRCT domain type II); NAD-dependent DNA ligase LigA 1523441 ligA 13702924 ligA Escherichia coli O104:H4 str. 2011C-3493 NAD-dependent DNA ligase LigA YP_006778177.1 1521426 D 1133852 CDS YP_006778178.1 407481029 13702925 1523443..1523661 1 NC_018658.1 COG3530 Uncharacterized protein conserved in bacteria; hypothetical protein 1523661 13702925 O3K_07350 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778178.1 1523443 D 1133852 CDS YP_006778179.1 407481030 13702926 complement(1523658..1524656) 1 NC_018658.1 COG0385 Predicted Na+-dependent transporter; hypothetical protein 1524656 13702926 O3K_07355 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778179.1 1523658 R 1133852 CDS YP_006778180.1 407481031 13702927 1524746..1525672 1 NC_018658.1 COG0583 Transcriptional regulator; LysR family transcriptional regulator 1525672 13702927 O3K_07360 Escherichia coli O104:H4 str. 2011C-3493 LysR family transcriptional regulator YP_006778180.1 1524746 D 1133852 CDS YP_006778181.1 407481032 13702928 complement(1525711..1526475) 1 NC_018658.1 hypothetical protein 1526475 13702928 O3K_07365 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778181.1 1525711 R 1133852 CDS YP_006778182.1 407481033 13702929 1526724..1527557 1 NC_018658.1 COG0005 Purine nucleoside phosphorylase; purine nucleoside phosphorylase 1527557 13702929 O3K_07370 Escherichia coli O104:H4 str. 2011C-3493 purine nucleoside phosphorylase YP_006778182.1 1526724 D 1133852 CDS YP_006778183.1 407481034 13702930 1527617..1528873 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; xanthosine transporter 1528873 13702930 O3K_07375 Escherichia coli O104:H4 str. 2011C-3493 xanthosine transporter YP_006778183.1 1527617 D 1133852 CDS YP_006778184.1 407481035 13702931 1528926..1529084 1 NC_018658.1 hypothetical protein 1529084 13702931 O3K_07380 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778184.1 1528926 D 1133852 CDS YP_006778185.1 407481036 13702932 1529125..1530009 1 NC_018658.1 COG0583 Transcriptional regulator; DNA-binding transcriptional activator XapR 1530009 13702932 O3K_07385 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional activator XapR YP_006778185.1 1529125 D 1133852 CDS YP_006778186.1 407481037 13702937 1530930..1532345 1 NC_018658.1 COG0008 Glutamyl- and glutaminyl-tRNA synthetases; glutamyl-tRNA synthetase 1532345 gltX 13702937 gltX Escherichia coli O104:H4 str. 2011C-3493 glutamyl-tRNA synthetase YP_006778186.1 1530930 D 1133852 CDS YP_006778187.1 407481038 13702938 complement(1532397..1532789) 1 NC_018658.1 COG1396 Predicted transcriptional regulators; putative DNA-binding transcriptional regulator 1532789 13702938 O3K_07395 Escherichia coli O104:H4 str. 2011C-3493 putative DNA-binding transcriptional regulator YP_006778187.1 1532397 R 1133852 CDS YP_006778188.1 407481039 13702939 complement(1532791..1533150) 1 NC_018658.1 hypothetical protein 1533150 13702939 O3K_07400 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778188.1 1532791 R 1133852 CDS YP_006778189.1 407481040 13702942 1533769..1535958 1 NC_018658.1 COG2199 FOG: GGDEF domain; diguanylate cyclase 1535958 13702942 O3K_07405 Escherichia coli O104:H4 str. 2011C-3493 diguanylate cyclase YP_006778189.1 1533769 D 1133852 CDS YP_006778190.1 407481041 13702943 complement(1536008..1537210) 1 NC_018658.1 COG1972 Nucleoside permease; nucleoside (except guanosine) transporter NupC 1537210 13702943 O3K_07410 Escherichia coli O104:H4 str. 2011C-3493 nucleoside (except guanosine) transporter NupC YP_006778190.1 1536008 R 1133852 CDS YP_006778191.1 407481042 13702944 1537546..1538784 1 NC_018658.1 COG1914 Mn2+ and Fe2+ transporters of the NRAMP family; manganese transport protein MntH 1538784 13702944 O3K_07415 Escherichia coli O104:H4 str. 2011C-3493 manganese transport protein MntH YP_006778191.1 1537546 D 1133852 CDS YP_006778192.1 407481043 13702945 complement(1538925..1539251) 1 NC_018658.1 hypothetical protein 1539251 13702945 O3K_07420 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778192.1 1538925 R 1133852 CDS YP_006778193.1 407481044 13702946 complement(1539366..1540622) 1 NC_018658.1 COG1284 Uncharacterized conserved protein; putative ion channel protein 1540622 13702946 O3K_07425 Escherichia coli O104:H4 str. 2011C-3493 putative ion channel protein YP_006778193.1 1539366 R 1133852 CDS YP_006778194.1 407481045 13702947 1540826..1541791 1 NC_018658.1 COG0837 Glucokinase; glucokinase 1541791 glk 13702947 glk Escherichia coli O104:H4 str. 2011C-3493 glucokinase YP_006778194.1 1540826 D 1133852 CDS YP_006778195.1 407481046 13702948 1542010..1542336 1 NC_018658.1 COG1445 Phosphotransferase system fructose-specific component IIB; PTS system transporter subunit IIB 1542336 13702948 O3K_07435 Escherichia coli O104:H4 str. 2011C-3493 PTS system transporter subunit IIB YP_006778195.1 1542010 D 1133852 CDS YP_006778196.1 407481047 13702949 1542358..1543605 1 NC_018658.1 COG1299 Phosphotransferase system, fructose-specific IIC component; fructose-like permease IIC component 1543605 13702949 O3K_07440 Escherichia coli O104:H4 str. 2011C-3493 fructose-like permease IIC component YP_006778196.1 1542358 D 1133852 CDS YP_006778197.1 407481048 13702950 1543620..1544705 1 NC_018658.1 COG0006 Xaa-Pro aminopeptidase; aminopeptidase 1544705 13702950 O3K_07445 Escherichia coli O104:H4 str. 2011C-3493 aminopeptidase YP_006778197.1 1543620 D 1133852 CDS YP_006778198.1 407481049 13702951 1544705..1545742 1 NC_018658.1 COG1363 Cellulase M and related proteins; exoaminopeptidase 1545742 13702951 O3K_07450 Escherichia coli O104:H4 str. 2011C-3493 exoaminopeptidase YP_006778198.1 1544705 D 1133852 CDS YP_006778199.1 407481050 13702952 1545767..1548262 1 NC_018658.1 multiphosphoryl transfer protein; COG1925 Phosphotransferase system, HPr-related proteins; PTS system transporter proteins Hpr/EI/IIA 1548262 13702952 O3K_07455 Escherichia coli O104:H4 str. 2011C-3493 PTS system transporter proteins Hpr/EI/IIA YP_006778199.1 1545767 D 1133852 CDS YP_006778200.1 407481051 13702953 complement(1548265..1549122) 1 NC_018658.1 COG2207 AraC-type DNA-binding domain-containing proteins; putative DNA-binding protein, ARAC-type 1549122 13702953 O3K_07460 Escherichia coli O104:H4 str. 2011C-3493 putative DNA-binding protein, ARAC-type YP_006778200.1 1548265 R 1133852 CDS YP_006778201.1 407481052 13702954 complement(1549135..1549869) 1 NC_018658.1 COG3279 Response regulator of the LytR/AlgR family; hypothetical protein 1549869 13702954 O3K_07465 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778201.1 1549135 R 1133852 CDS YP_006778202.1 407481053 13702955 complement(1549884..1551581) 1 NC_018658.1 COG3275 Putative regulator of cell autolysis; hypothetical protein 1551581 13702955 O3K_07470 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778202.1 1549884 R 1133852 CDS YP_006778203.1 407481054 13702956 1551958..1553196 1 NC_018658.1 COG0436 Aspartate/tyrosine/aromatic aminotransferase; aminotransferase 1553196 13702956 O3K_07475 Escherichia coli O104:H4 str. 2011C-3493 aminotransferase YP_006778203.1 1551958 D 1133852 CDS YP_006778204.1 407481055 13702957 complement(1553688..1554608) 1 NC_018658.1 COG1560 Lauroyl/myristoyl acyltransferase; lipid A biosynthesis palmitoleoyl acyltransferase 1554608 13702957 O3K_07480 Escherichia coli O104:H4 str. 2011C-3493 lipid A biosynthesis palmitoleoyl acyltransferase YP_006778204.1 1553688 R 1133852 CDS YP_006778205.1 407481056 13702958 1554961..1555203 1 NC_018658.1 inner membrane protein 1555203 13702958 O3K_07485 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006778205.1 1554961 D 1133852 CDS YP_006778206.1 407481057 13702959 complement(1555280..1555555) 1 NC_018658.1 lipoprotein 1555555 13702959 O3K_07490 Escherichia coli O104:H4 str. 2011C-3493 lipoprotein YP_006778206.1 1555280 R 1133852 CDS YP_006778207.1 407481058 13702960 1555851..1556483 1 NC_018658.1 hypothetical protein 1556483 13702960 O3K_07495 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778207.1 1555851 D 1133852 CDS YP_006778208.1 407481059 13702961 1556996..1558246 1 NC_018658.1 COG1804 Predicted acyl-CoA transferases/carnitine dehydratase; formyl-coenzyme A transferase 1558246 13702961 O3K_07500 Escherichia coli O104:H4 str. 2011C-3493 formyl-coenzyme A transferase YP_006778208.1 1556996 D 1133852 CDS YP_006778209.1 407481060 13702962 1558300..1559994 1 NC_018658.1 COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; putative oxalyl-CoA decarboxylase 1559994 13702962 O3K_07505 Escherichia coli O104:H4 str. 2011C-3493 putative oxalyl-CoA decarboxylase YP_006778209.1 1558300 D 1133852 CDS YP_006778210.1 407481061 13702963 1560064..1561008 1 NC_018658.1 COG0679 Predicted permeases; putative transporter YfdV 1561008 13702963 O3K_07510 Escherichia coli O104:H4 str. 2011C-3493 putative transporter YfdV YP_006778210.1 1560064 D 1133852 CDS YP_006778211.1 407481062 13702964 1561082..1562227 1 NC_018658.1 COG1804 Predicted acyl-CoA transferases/carnitine dehydratase; putative CoA-transferase 1562227 13702964 O3K_07515 Escherichia coli O104:H4 str. 2011C-3493 putative CoA-transferase YP_006778211.1 1561082 D 1133852 CDS YP_006778212.1 407481063 13702965 complement(1562283..1565876) 1 NC_018658.1 COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; hybrid sensory histidine kinase in two-component regulatory system with EvgA 1565876 13702965 O3K_07520 Escherichia coli O104:H4 str. 2011C-3493 hybrid sensory histidine kinase in two-component regulatory system with EvgA YP_006778212.1 1562283 R 1133852 CDS YP_006778213.1 407481064 13702966 complement(1565881..1566495) 1 NC_018658.1 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; DNA-binding transcriptional activator EvgA 1566495 13702966 O3K_07525 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional activator EvgA YP_006778213.1 1565881 R 1133852 CDS YP_006778214.1 407481065 13702967 1566911..1568074 1 NC_018658.1 COG1566 Multidrug resistance efflux pump; EmrKY-TolC multidrug resistance efflux pump, membrane fusion protein component 1568074 13702967 O3K_07530 Escherichia coli O104:H4 str. 2011C-3493 EmrKY-TolC multidrug resistance efflux pump, membrane fusion protein component YP_006778214.1 1566911 D 1133852 CDS YP_006778215.1 407481066 13702968 1568074..1569612 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; putative multidrug efflux system protein Y 1569612 13702968 O3K_07535 Escherichia coli O104:H4 str. 2011C-3493 putative multidrug efflux system protein Y YP_006778215.1 1568074 D 1133852 CDS YP_006778216.1 407481067 13702969 complement(1569720..1571048) 1 NC_018658.1 COG3048 D-serine dehydratase; D-serine dehydratase 1571048 13702969 O3K_07540 Escherichia coli O104:H4 str. 2011C-3493 D-serine dehydratase YP_006778216.1 1569720 R 1133852 CDS YP_006778217.1 407481068 13702970 complement(1571066..1571284) 1 NC_018658.1 COG2610 H+/gluconate symporter and related permeases; permease DsdX 1571284 13702970 O3K_07545 Escherichia coli O104:H4 str. 2011C-3493 permease DsdX YP_006778217.1 1571066 R 1133852 CDS YP_006778218.1 407481069 13702971 1571515..1572510 1 NC_018658.1 COG1609 Transcriptional regulators; sucrose operon repressor 1572510 13702971 O3K_07550 Escherichia coli O104:H4 str. 2011C-3493 sucrose operon repressor YP_006778218.1 1571515 D 1133852 CDS YP_006778219.1 407481070 13702972 complement(1572518..1573951) 1 NC_018658.1 COG1621 Beta-fructosidases (levanase/invertase); sucrose-6-phosphate hydrolase 1573951 13702972 O3K_07555 Escherichia coli O104:H4 str. 2011C-3493 sucrose-6-phosphate hydrolase YP_006778219.1 1572518 R 1133852 CDS YP_006778220.1 407481071 13702973 1574167..1575081 1 NC_018658.1 COG0524 Sugar kinases, ribokinase family; aminoimidazole riboside kinase 1575081 13702973 O3K_07560 Escherichia coli O104:H4 str. 2011C-3493 aminoimidazole riboside kinase YP_006778220.1 1574167 D 1133852 CDS YP_006778221.1 407481072 13702974 1575153..1576400 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; galactoside permease 1576400 lacY 13702974 lacY Escherichia coli O104:H4 str. 2011C-3493 galactoside permease YP_006778221.1 1575153 D 1133852 CDS YP_006778222.1 407481073 13702975 complement(1576930..1577130) 1 NC_018658.1 hypothetical protein 1577130 13702975 O3K_07570 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778222.1 1576930 R 1133852 CDS YP_006778223.1 407481074 13702976 complement(1577262..1577441) 1 NC_018658.1 hypothetical protein 1577441 13702976 O3K_07575 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778223.1 1577262 R 1133852 CDS YP_006778224.1 407481075 13702977 complement(1578164..1578373) 1 NC_018658.1 prophage protein 1578373 13702977 O3K_07585 Escherichia coli O104:H4 str. 2011C-3493 prophage protein YP_006778224.1 1578164 R 1133852 CDS YP_006778225.1 407481076 13702978 complement(1578736..1579407) 1 NC_018658.1 COG0529 Adenylylsulfate kinase and related kinases; hypothetical protein 1579407 13702978 O3K_07590 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778225.1 1578736 R 1133852 CDS YP_006778226.1 407481077 13702979 complement(1579404..1579571) 1 NC_018658.1 hypothetical protein 1579571 13702979 O3K_07595 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778226.1 1579404 R 1133852 CDS YP_006778227.1 407481078 13702980 complement(1579568..1579858) 1 NC_018658.1 hypothetical protein 1579858 13702980 O3K_07600 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778227.1 1579568 R 1133852 CDS YP_006778228.1 407481079 13702981 complement(1579869..1580165) 1 NC_018658.1 Anti-RecBCD protein 2 1580165 13702981 O3K_07605 Escherichia coli O104:H4 str. 2011C-3493 Anti-RecBCD protein 2 YP_006778228.1 1579869 R 1133852 CDS YP_006778229.1 407481080 13702982 complement(1580189..1580572) 1 NC_018658.1 hypothetical protein 1580572 13702982 O3K_07610 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778229.1 1580189 R 1133852 CDS YP_006778230.1 407481081 13702983 complement(1580572..1581177) 1 NC_018658.1 DNA single-strand annealing protein, essential recombination function protein Erf 1581177 13702983 O3K_07615 Escherichia coli O104:H4 str. 2011C-3493 DNA single-strand annealing protein, essential recombination function protein Erf YP_006778230.1 1580572 R 1133852 CDS YP_006778231.1 407481082 13702984 complement(1581188..1581358) 1 NC_018658.1 hypothetical protein 1581358 13702984 O3K_07620 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778231.1 1581188 R 1133852 CDS YP_006778232.1 407481083 13702985 complement(1581267..1581437) 1 NC_018658.1 hypothetical protein 1581437 13702985 O3K_07625 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778232.1 1581267 R 1133852 CDS YP_006778233.1 407481084 13702986 complement(1581434..1581586) 1 NC_018658.1 host killing protein 1581586 13702986 O3K_07630 Escherichia coli O104:H4 str. 2011C-3493 host killing protein YP_006778233.1 1581434 R 1133852 CDS YP_006778234.1 407481085 13702987 complement(1581571..1581702) 1 NC_018658.1 regulatory protein CIII 1581702 13702987 O3K_07635 Escherichia coli O104:H4 str. 2011C-3493 regulatory protein CIII YP_006778234.1 1581571 R 1133852 CDS YP_006778235.1 407481086 13702988 1581932..1582207 1 NC_018658.1 COG3677 Transposase and inactivated derivatives; InsA 1582207 13702988 O3K_07640 Escherichia coli O104:H4 str. 2011C-3493 InsA YP_006778235.1 1581932 D 1133852 CDS YP_006778236.1 407481087 13702989 1582126..1582629 1 NC_018658.1 COG1662 Transposase and inactivated derivatives, IS1 family; transposase InsB IS1 1582629 13702989 O3K_07645 Escherichia coli O104:H4 str. 2011C-3493 transposase InsB IS1 YP_006778236.1 1582126 D 1133852 CDS YP_006778237.1 407481088 13702990 1582749..1582991 1 NC_018658.1 hypothetical protein 1582991 13702990 O3K_07650 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778237.1 1582749 D 1133852 CDS YP_006778238.1 407481089 13702991 1582994..1583434 1 NC_018658.1 hypothetical protein 1583434 13702991 O3K_07655 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778238.1 1582994 D 1133852 CDS YP_006778239.1 407481090 13702992 1583431..1584843 1 NC_018658.1 COG1783 Phage terminase large subunit; terminase large subunit 1584843 13702992 O3K_07660 Escherichia coli O104:H4 str. 2011C-3493 terminase large subunit YP_006778239.1 1583431 D 1133852 CDS YP_006778240.1 407481091 13702993 1584882..1586972 1 NC_018658.1 portal protein p19 1586972 13702993 O3K_07665 Escherichia coli O104:H4 str. 2011C-3493 portal protein p19 YP_006778240.1 1584882 D 1133852 CDS YP_006778241.1 407481092 13702994 1586986..1587870 1 NC_018658.1 scaffold protein 1587870 13702994 O3K_07670 Escherichia coli O104:H4 str. 2011C-3493 scaffold protein YP_006778241.1 1586986 D 1133852 CDS YP_006778242.1 407481093 13702995 1587882..1589153 1 NC_018658.1 Major head protein (p24) (Major coat protein) 1589153 13702995 O3K_07675 Escherichia coli O104:H4 str. 2011C-3493 Major head protein (p24) (Major coat protein) YP_006778242.1 1587882 D 1133852 CDS YP_006778243.1 407481094 13702996 1589196..1589381 1 NC_018658.1 phage protein 1589381 13702996 O3K_07680 Escherichia coli O104:H4 str. 2011C-3493 phage protein YP_006778243.1 1589196 D 1133852 CDS YP_006778244.1 407481095 13702997 1589356..1589838 1 NC_018658.1 packaged DNA stabilization protein p27 1589838 13702997 O3K_07685 Escherichia coli O104:H4 str. 2011C-3493 packaged DNA stabilization protein p27 YP_006778244.1 1589356 D 1133852 CDS YP_006778245.1 407481096 13702998 1589847..1591265 1 NC_018658.1 Packaged DNA stabilization protein from phage 1591265 13702998 O3K_07690 Escherichia coli O104:H4 str. 2011C-3493 Packaged DNA stabilization protein from phage YP_006778245.1 1589847 D 1133852 CDS YP_006778246.1 407481097 13702999 1591265..1592113 1 NC_018658.1 head DNA stabilization protein 1592113 13702999 O3K_07695 Escherichia coli O104:H4 str. 2011C-3493 head DNA stabilization protein YP_006778246.1 1591265 D 1133852 CDS YP_006778247.1 407481098 13703000 1592113..1592568 1 NC_018658.1 Head assembly protein 1592568 13703000 O3K_07700 Escherichia coli O104:H4 str. 2011C-3493 Head assembly protein YP_006778247.1 1592113 D 1133852 CDS YP_006778248.1 407481099 13703001 1592571..1593263 1 NC_018658.1 putative DNA transfer protein 1593263 13703001 O3K_07705 Escherichia coli O104:H4 str. 2011C-3493 putative DNA transfer protein YP_006778248.1 1592571 D 1133852 CDS YP_006778249.1 407481100 13703002 1593273..1594739 1 NC_018658.1 APSE-2 prophage, transfer protein gp20 1594739 13703002 O3K_07710 Escherichia coli O104:H4 str. 2011C-3493 APSE-2 prophage, transfer protein gp20 YP_006778249.1 1593273 D 1133852 CDS YP_006778250.1 407481101 13703003 1594739..1596583 1 NC_018658.1 DNA injection protein 1596583 13703003 O3K_07715 Escherichia coli O104:H4 str. 2011C-3493 DNA injection protein YP_006778250.1 1594739 D 1133852 CDS YP_006778251.1 407481102 13703004 complement(1596598..1597083) 1 NC_018658.1 lipoprotein 1597083 13703004 O3K_07720 Escherichia coli O104:H4 str. 2011C-3493 lipoprotein YP_006778251.1 1596598 R 1133852 CDS YP_006778252.1 407481103 13703005 complement(1597109..1597423) 1 NC_018658.1 hypothetical protein 1597423 13703005 O3K_07725 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778252.1 1597109 R 1133852 CDS YP_006778253.1 407481104 13703006 complement(1597420..1597671) 1 NC_018658.1 hypothetical protein 1597671 13703006 O3K_07730 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778253.1 1597420 R 1133852 CDS YP_006778254.1 407481105 13703007 1597777..1597917 1 NC_018658.1 hypothetical protein 1597917 13703007 O3K_07735 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778254.1 1597777 D 1133852 CDS YP_006778255.1 407481106 13703008 1598150..1599028 1 NC_018658.1 COG3617 Prophage antirepressor; antirepressor protein encoded by prophage CP-933N 1599028 13703008 O3K_07740 Escherichia coli O104:H4 str. 2011C-3493 antirepressor protein encoded by prophage CP-933N YP_006778255.1 1598150 D 1133852 CDS YP_006778256.1 407481107 13703009 1599129..1601108 1 NC_018658.1 hypothetical protein 1601108 13703009 O3K_07745 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778256.1 1599129 D 1133852 CDS YP_006778257.1 407481108 13703010 complement(1601179..1603089) 1 NC_018658.1 COG1835 Predicted acyltransferases; hypothetical protein 1603089 13703010 O3K_07750 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778257.1 1601179 R 1133852 CDS YP_006778258.1 407481109 13703011 complement(1603318..1604475) 1 NC_018658.1 COG0582 Integrase; prophage CPS-53 integrase, CPS-53 (KpLE1) prophage 1604475 13703011 O3K_07755 Escherichia coli O104:H4 str. 2011C-3493 prophage CPS-53 integrase, CPS-53 (KpLE1) prophage YP_006778258.1 1603318 R 1133852 CDS YP_006778259.1 407481110 13703013 complement(1604787..1605719) 1 NC_018658.1 COG2116 Formate/nitrite family of transporters; hypothetical protein 1605719 13703013 O3K_07760 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778259.1 1604787 R 1133852 CDS YP_006778260.1 407481111 13703014 1606013..1606768 1 NC_018658.1 COG2853 Surface lipoprotein; ABC transporter outer membrane lipoprotein 1606768 13703014 O3K_07765 Escherichia coli O104:H4 str. 2011C-3493 ABC transporter outer membrane lipoprotein YP_006778260.1 1606013 D 1133852 CDS YP_006778261.1 407481112 13703015 complement(1606950..1608008) 1 NC_018658.1 hypothetical protein 1608008 13703015 O3K_07770 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778261.1 1606950 R 1133852 CDS YP_006778262.1 407481113 13703016 complement(1608374..1609714) 1 NC_018658.1 COG2067 Long-chain fatty acid transport protein; long-chain fatty acid outer membrane transporter 1609714 13703016 O3K_07775 Escherichia coli O104:H4 str. 2011C-3493 long-chain fatty acid outer membrane transporter YP_006778262.1 1608374 R 1133852 CDS YP_006778263.1 407481114 13703017 1610086..1610370 1 NC_018658.1 COG3691 Uncharacterized protein conserved in bacteria; hypothetical protein 1610370 13703017 O3K_07780 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778263.1 1610086 D 1133852 CDS YP_006778264.1 407481115 13703018 1610550..1611860 1 NC_018658.1 COG0183 Acetyl-CoA acetyltransferase; 3-ketoacyl-CoA thiolase 1611860 fadI 13703018 fadI Escherichia coli O104:H4 str. 2011C-3493 3-ketoacyl-CoA thiolase YP_006778264.1 1610550 D 1133852 CDS YP_006778265.1 407481116 13703019 1611860..1614004 1 NC_018658.1 COG1024 Enoyl-CoA hydratase/carnithine racemase; multifunctional fatty acid oxidation complex subunit alpha 1614004 fadJ 13703019 fadJ Escherichia coli O104:H4 str. 2011C-3493 multifunctional fatty acid oxidation complex subunit alpha YP_006778265.1 1611860 D 1133852 CDS YP_006778266.1 407481117 13703020 1614207..1614692 1 NC_018658.1 COG2062 Phosphohistidine phosphatase SixA; phosphohistidine phosphatase 1614692 13703020 O3K_07795 Escherichia coli O104:H4 str. 2011C-3493 phosphohistidine phosphatase YP_006778266.1 1614207 D 1133852 CDS YP_006778267.1 407481118 13703021 1615367..1615930 1 NC_018658.1 putative fimbrial-like protein 1615930 13703021 O3K_07800 Escherichia coli O104:H4 str. 2011C-3493 putative fimbrial-like protein YP_006778267.1 1615367 D 1133852 CDS YP_006778268.1 407481119 13703022 1616012..1618654 1 NC_018658.1 COG3188 P pilus assembly protein, porin PapC; putative fimbrial outer membrane usher protein StfC 1618654 13703022 O3K_07805 Escherichia coli O104:H4 str. 2011C-3493 putative fimbrial outer membrane usher protein StfC YP_006778268.1 1616012 D 1133852 CDS YP_006778269.1 407481120 13703023 1618674..1619426 1 NC_018658.1 COG3121 P pilus assembly protein, chaperone PapD; chaperone 1619426 13703023 O3K_07810 Escherichia coli O104:H4 str. 2011C-3493 chaperone YP_006778269.1 1618674 D 1133852 CDS YP_006778270.1 407481121 13703024 1619443..1619949 1 NC_018658.1 minor fimbrial subunit 1619949 13703024 O3K_07815 Escherichia coli O104:H4 str. 2011C-3493 minor fimbrial subunit YP_006778270.1 1619443 D 1133852 CDS YP_006778271.1 407481122 13703025 1619946..1620416 1 NC_018658.1 fimbrial subunit protein 1620416 13703025 O3K_07820 Escherichia coli O104:H4 str. 2011C-3493 fimbrial subunit protein YP_006778271.1 1619946 D 1133852 CDS YP_006778272.1 407481123 13703026 1620413..1620937 1 NC_018658.1 COG3539 P pilus assembly protein, pilin FimA; fimbrial subunit protein 1620937 13703026 O3K_07825 Escherichia coli O104:H4 str. 2011C-3493 fimbrial subunit protein YP_006778272.1 1620413 D 1133852 CDS YP_006778273.1 407481124 13703027 1621518..1621796 1 NC_018658.1 hypothetical protein 1621796 13703027 O3K_07830 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778273.1 1621518 D 1133852 CDS YP_006778274.1 407481125 13703028 1622023..1623003 1 NC_018658.1 COG3547 Transposase and inactivated derivatives; IS621 transposase 1623003 13703028 O3K_07835 Escherichia coli O104:H4 str. 2011C-3493 IS621 transposase YP_006778274.1 1622023 D 1133852 CDS YP_006778275.1 407481126 13703029 complement(1623197..1623748) 1 NC_018658.1 COG2840 Uncharacterized protein conserved in bacteria; hypothetical protein 1623748 13703029 O3K_07840 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778275.1 1623197 R 1133852 CDS YP_006778276.1 407481127 13703030 1623914..1624846 1 NC_018658.1 COG2890 Methylase of polypeptide chain release factors; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 1624846 13703030 O3K_07845 Escherichia coli O104:H4 str. 2011C-3493 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase YP_006778276.1 1623914 D 1133852 CDS YP_006778277.1 407481128 13703031 1624881..1625966 1 NC_018658.1 COG0082 Chorismate synthase; chorismate synthase 1625966 13703031 O3K_07850 Escherichia coli O104:H4 str. 2011C-3493 chorismate synthase YP_006778277.1 1624881 D 1133852 CDS YP_006778278.1 407481129 13703032 1625970..1626794 1 NC_018658.1 COG3770 Murein endopeptidase; penicillin-insensitive murein endopeptidase 1626794 mepA 13703032 mepA Escherichia coli O104:H4 str. 2011C-3493 penicillin-insensitive murein endopeptidase YP_006778278.1 1625970 D 1133852 CDS YP_006778279.1 407481130 13703033 1626794..1627603 1 NC_018658.1 COG0730 Predicted permeases; hypothetical protein 1627603 13703033 O3K_07860 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778279.1 1626794 D 1133852 CDS YP_006778280.1 407481131 13703034 1627603..1628151 1 NC_018658.1 COG3101 Uncharacterized protein conserved in bacteria; hypothetical protein 1628151 13703034 O3K_07865 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778280.1 1627603 D 1133852 CDS YP_006778281.1 407481132 13703035 1628185..1628463 1 NC_018658.1 hypothetical protein 1628463 13703035 O3K_07870 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778281.1 1628185 D 1133852 CDS YP_006778282.1 407481133 13703036 complement(1628584..1630590) 1 NC_018658.1 COG4121 Uncharacterized conserved protein; bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase 1630590 mnmC 13703036 mnmC Escherichia coli O104:H4 str. 2011C-3493 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase YP_006778282.1 1628584 R 1133852 CDS YP_006778283.1 407481134 13703037 1630749..1631969 1 NC_018658.1 COG0304 3-oxoacyl-(acyl-carrier-protein) synthase; 3-oxoacyl-ACP synthase 1631969 13703037 O3K_07880 Escherichia coli O104:H4 str. 2011C-3493 3-oxoacyl-ACP synthase YP_006778283.1 1630749 D 1133852 CDS YP_006778284.1 407481135 13703038 1632253..1633431 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; transporter 1633431 13703038 O3K_07885 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006778284.1 1632253 D 1133852 CDS YP_006778285.1 407481136 13703039 complement(1633428..1634423) 1 NC_018658.1 flagella biosynthesis regulator 1634423 flk 13703039 flk Escherichia coli O104:H4 str. 2011C-3493 flagella biosynthesis regulator YP_006778285.1 1633428 R 1133852 CDS YP_006778286.1 407481137 13703040 1634522..1635658 1 NC_018658.1 COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; erythronate-4-phosphate dehydrogenase PdxB 1635658 13703040 O3K_07895 Escherichia coli O104:H4 str. 2011C-3493 erythronate-4-phosphate dehydrogenase PdxB YP_006778286.1 1634522 D 1133852 CDS YP_006778287.1 407481138 13703041 1635724..1636737 1 NC_018658.1 COG0136 Aspartate-semialdehyde dehydrogenase; putative semialdehyde dehydrogenase 1636737 13703041 O3K_07900 Escherichia coli O104:H4 str. 2011C-3493 putative semialdehyde dehydrogenase YP_006778287.1 1635724 D 1133852 CDS YP_006778288.1 407481139 13703042 1636737..1637549 1 NC_018658.1 COG0101 Pseudouridylate synthase; tRNA pseudouridine synthase A 1637549 truA 13703042 truA Escherichia coli O104:H4 str. 2011C-3493 tRNA pseudouridine synthase A YP_006778288.1 1636737 D 1133852 CDS YP_006778289.1 407481140 13703043 1637632..1638291 1 NC_018658.1 COG0586 Uncharacterized membrane-associated protein; hypothetical protein 1638291 13703043 O3K_07910 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778289.1 1637632 D 1133852 CDS YP_006778290.1 407481141 13703044 1638447..1639361 1 NC_018658.1 COG0777 Acetyl-CoA carboxylase beta subunit; acetyl-CoA carboxylase subunit beta 1639361 13703044 O3K_07915 Escherichia coli O104:H4 str. 2011C-3493 acetyl-CoA carboxylase subunit beta YP_006778290.1 1638447 D 1133852 CDS YP_006778291.1 407481142 13703045 1639431..1640699 1 NC_018658.1 COG0285 Folylpolyglutamate synthase; bifunctional folylpolyglutamate synthase/dihydrofolate synthase 1640699 13703045 O3K_07920 Escherichia coli O104:H4 str. 2011C-3493 bifunctional folylpolyglutamate synthase/dihydrofolate synthase YP_006778291.1 1639431 D 1133852 CDS YP_006778292.1 407481143 13703046 1640689..1641351 1 NC_018658.1 COG3147 Uncharacterized protein conserved in bacteria; cell division protein DedD 1641351 13703046 O3K_07925 Escherichia coli O104:H4 str. 2011C-3493 cell division protein DedD YP_006778292.1 1640689 D 1133852 CDS YP_006778293.1 407481144 13703047 1641610..1642098 1 NC_018658.1 COG1286 Uncharacterized membrane protein, required for colicin V production; colicin V production protein 1642098 13703047 O3K_07930 Escherichia coli O104:H4 str. 2011C-3493 colicin V production protein YP_006778293.1 1641610 D 1133852 CDS YP_006778294.1 407481145 13703048 1642135..1643652 1 NC_018658.1 COG0034 Glutamine phosphoribosylpyrophosphate amidotransferase; amidophosphoribosyltransferase 1643652 13703048 O3K_07935 Escherichia coli O104:H4 str. 2011C-3493 amidophosphoribosyltransferase YP_006778294.1 1642135 D 1133852 CDS YP_006778295.1 407481146 13703049 1643747..1644316 1 NC_018658.1 COG0163 3-polyprenyl-4-hydroxybenzoate decarboxylase; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase 1644316 13703049 O3K_07940 Escherichia coli O104:H4 str. 2011C-3493 3-octaprenyl-4-hydroxybenzoate carboxy-lyase YP_006778295.1 1643747 D 1133852 CDS YP_006778296.1 407481147 13703050 1644582..1645364 1 NC_018658.1 COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; lysine/arginine/ornithine ABC transporter substrate-binding protein 1645364 13703050 O3K_07945 Escherichia coli O104:H4 str. 2011C-3493 lysine/arginine/ornithine ABC transporter substrate-binding protein YP_006778296.1 1644582 D 1133852 CDS YP_006778297.1 407481148 13703051 1645585..1646367 1 NC_018658.1 COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; histidine ABC transporter substrate-binding protein HisJ 1646367 13703051 O3K_07950 Escherichia coli O104:H4 str. 2011C-3493 histidine ABC transporter substrate-binding protein HisJ YP_006778297.1 1645585 D 1133852 CDS YP_006778298.1 407481149 13703052 1646457..1647143 1 NC_018658.1 COG4215 ABC-type arginine transport system, permease component; histidine/lysine/arginine/ornithine ABC transporter permease HisQ 1647143 13703052 O3K_07955 Escherichia coli O104:H4 str. 2011C-3493 histidine/lysine/arginine/ornithine ABC transporter permease HisQ YP_006778298.1 1646457 D 1133852 CDS YP_006778299.1 407481150 13703053 1647140..1647856 1 NC_018658.1 COG4160 ABC-type arginine/histidine transport system, permease component; histidine/lysine/arginine/ornithine ABC transporter permease HisM 1647856 13703053 O3K_07960 Escherichia coli O104:H4 str. 2011C-3493 histidine/lysine/arginine/ornithine ABC transporter permease HisM YP_006778299.1 1647140 D 1133852 CDS YP_006778300.1 407481151 13703054 1647864..1648637 1 NC_018658.1 COG4598 ABC-type histidine transport system, ATPase component; histidine/lysine/arginine/ornithine transporter subunit 1648637 13703054 O3K_07965 Escherichia coli O104:H4 str. 2011C-3493 histidine/lysine/arginine/ornithine transporter subunit YP_006778300.1 1647864 D 1133852 CDS YP_006778301.1 407481152 13703055 1648834..1649736 1 NC_018658.1 transposase 1649736 13703055 O3K_07970 Escherichia coli O104:H4 str. 2011C-3493 transposase YP_006778301.1 1648834 D 1133852 CDS YP_006778302.1 407481153 13703056 complement(1649784..1650677) 1 NC_018658.1 hypothetical protein; COG1090 Predicted nucleoside-diphosphate sugar epimerase; NAD dependent epimerase/dehydratase family protein 1650677 13703056 O3K_07975 Escherichia coli O104:H4 str. 2011C-3493 NAD dependent epimerase/dehydratase family protein YP_006778302.1 1649784 R 1133852 CDS YP_006778303.1 407481154 13703057 complement(1650698..1651060) 1 NC_018658.1 COG1539 Dihydroneopterin aldolase; D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase 1651060 folX 13703057 folX Escherichia coli O104:H4 str. 2011C-3493 D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase YP_006778303.1 1650698 R 1133852 CDS YP_006778304.1 407481155 13703058 complement(1651117..1651764) 1 NC_018658.1 COG0625 Glutathione S-transferase; GSH-dependent disulfide bond oxidoreductase 1651764 13703058 O3K_07985 Escherichia coli O104:H4 str. 2011C-3493 GSH-dependent disulfide bond oxidoreductase YP_006778304.1 1651117 R 1133852 CDS YP_006778305.1 407481156 13703059 1651900..1652544 1 NC_018658.1 COG0625 Glutathione S-transferase; glutathione S-transferase 1652544 13703059 O3K_07990 Escherichia coli O104:H4 str. 2011C-3493 glutathione S-transferase YP_006778305.1 1651900 D 1133852 CDS YP_006778306.1 407481157 13703060 1652600..1653151 1 NC_018658.1 COG0622 Predicted phosphoesterase; phosphodiesterase 1653151 13703060 O3K_07995 Escherichia coli O104:H4 str. 2011C-3493 phosphodiesterase YP_006778306.1 1652600 D 1133852 CDS YP_006778307.1 407481158 13703061 1653209..1653751 1 NC_018658.1 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; NUDIX hydrolase YfcD 1653751 13703061 O3K_08000 Escherichia coli O104:H4 str. 2011C-3493 NUDIX hydrolase YfcD YP_006778307.1 1653209 D 1133852 CDS YP_006778308.1 407481159 13703062 complement(1653784..1655304) 1 NC_018658.1 COG1288 Predicted membrane protein; hypothetical protein 1655304 13703062 O3K_08005 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778308.1 1653784 R 1133852 CDS YP_006778309.1 407481160 13703063 complement(1655494..1657638) 1 NC_018658.1 COG0857 BioD-like N-terminal domain of phosphotransacetylase; phosphate acetyltransferase 1657638 13703063 O3K_08010 Escherichia coli O104:H4 str. 2011C-3493 phosphate acetyltransferase YP_006778309.1 1655494 R 1133852 CDS YP_006778310.1 407481161 13703064 complement(1657713..1658915) 1 NC_018658.1 COG0282 Acetate kinase; acetate kinase A/propionate kinase 2 1658915 13703064 O3K_08015 Escherichia coli O104:H4 str. 2011C-3493 acetate kinase A/propionate kinase 2 YP_006778310.1 1657713 R 1133852 CDS YP_006778311.1 407481162 13703065 1659053..1659184 1 NC_018658.1 hypothetical protein 1659184 13703065 O3K_08020 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778311.1 1659053 D 1133852 CDS YP_006778312.1 407481163 13703066 1659253..1659708 1 NC_018658.1 COG3092 Uncharacterized protein conserved in bacteria; hypothetical protein 1659708 13703066 O3K_08025 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778312.1 1659253 D 1133852 CDS YP_006778313.1 407481164 13703067 1659791..1660285 1 NC_018658.1 COG3013 Uncharacterized conserved protein; hypothetical protein 1660285 13703067 O3K_08030 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778313.1 1659791 D 1133852 CDS YP_006778314.1 407481165 13703068 1660296..1660946 1 NC_018658.1 COG0637 Predicted phosphatase/phosphohexomutase; putative phosphatase 1660946 13703068 O3K_08035 Escherichia coli O104:H4 str. 2011C-3493 putative phosphatase YP_006778314.1 1660296 D 1133852 CDS YP_006778315.1 407481166 13703069 1661033..1662865 1 NC_018658.1 COG0471 Di- and tricarboxylate transporters; transporter 1662865 13703069 O3K_08040 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006778315.1 1661033 D 1133852 CDS YP_006778316.1 407481167 13703070 complement(1662924..1663523) 1 NC_018658.1 COG1896 Predicted hydrolases of HD superfamily; 5'-nucleotidase 1663523 13703070 O3K_08045 Escherichia coli O104:H4 str. 2011C-3493 5'-nucleotidase YP_006778316.1 1662924 R 1133852 CDS YP_006778317.1 407481168 13703071 complement(1663607..1664824) 1 NC_018658.1 COG0436 Aspartate/tyrosine/aromatic aminotransferase; aminotransferase AlaT 1664824 13703071 O3K_08050 Escherichia coli O104:H4 str. 2011C-3493 aminotransferase AlaT YP_006778317.1 1663607 R 1133852 CDS YP_006778318.1 407481169 13703072 1665744..1666682 1 NC_018658.1 COG0583 Transcriptional regulator; DNA-binding transcriptional repressor LrhA 1666682 13703072 O3K_08055 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional repressor LrhA YP_006778318.1 1665744 D 1133852 CDS YP_006778319.1 407481170 13703073 1667313..1667756 1 NC_018658.1 COG0838 NADH:ubiquinone oxidoreductase subunit 3 (chain A); NADH:ubiquinone oxidoreductase subunit A 1667756 13703073 O3K_08060 Escherichia coli O104:H4 str. 2011C-3493 NADH:ubiquinone oxidoreductase subunit A YP_006778319.1 1667313 D 1133852 CDS YP_006778320.1 407481171 13703074 1667772..1668434 1 NC_018658.1 COG0377 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases; NADH dehydrogenase subunit B 1668434 13703074 O3K_08065 Escherichia coli O104:H4 str. 2011C-3493 NADH dehydrogenase subunit B YP_006778320.1 1667772 D 1133852 CDS YP_006778321.1 407481172 13703075 1668528..1670330 1 NC_018658.1 COG0852 NADH:ubiquinone oxidoreductase 27 kD subunit; NADH:ubiquinone oxidoreductase subunit C/D 1670330 13703075 O3K_08070 Escherichia coli O104:H4 str. 2011C-3493 NADH:ubiquinone oxidoreductase subunit C/D YP_006778321.1 1668528 D 1133852 CDS YP_006778322.1 407481173 13703076 1670333..1670833 1 NC_018658.1 COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit; NADH dehydrogenase subunit E 1670833 13703076 O3K_08075 Escherichia coli O104:H4 str. 2011C-3493 NADH dehydrogenase subunit E YP_006778322.1 1670333 D 1133852 CDS YP_006778323.1 407481174 13703077 1670830..1672167 1 NC_018658.1 COG1894 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit; NADH dehydrogenase I subunit F 1672167 13703077 O3K_08080 Escherichia coli O104:H4 str. 2011C-3493 NADH dehydrogenase I subunit F YP_006778323.1 1670830 D 1133852 CDS YP_006778324.1 407481175 13703078 1672220..1674946 1 NC_018658.1 COG1034 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G); NADH dehydrogenase subunit G 1674946 13703078 O3K_08085 Escherichia coli O104:H4 str. 2011C-3493 NADH dehydrogenase subunit G YP_006778324.1 1672220 D 1133852 CDS YP_006778325.1 407481176 13703079 1674943..1675920 1 NC_018658.1 COG1005 NADH:ubiquinone oxidoreductase subunit 1 (chain H); NADH:ubiquinone oxidoreductase subunit H 1675920 13703079 O3K_08090 Escherichia coli O104:H4 str. 2011C-3493 NADH:ubiquinone oxidoreductase subunit H YP_006778325.1 1674943 D 1133852 CDS YP_006778326.1 407481177 13703080 1675935..1676477 1 NC_018658.1 COG1143 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I); NADH dehydrogenase subunit I 1676477 13703080 O3K_08095 Escherichia coli O104:H4 str. 2011C-3493 NADH dehydrogenase subunit I YP_006778326.1 1675935 D 1133852 CDS YP_006778327.1 407481178 13703081 1676489..1677043 1 NC_018658.1 COG0839 NADH:ubiquinone oxidoreductase subunit 6 (chain J); NADH:ubiquinone oxidoreductase subunit J 1677043 13703081 O3K_08100 Escherichia coli O104:H4 str. 2011C-3493 NADH:ubiquinone oxidoreductase subunit J YP_006778327.1 1676489 D 1133852 CDS YP_006778328.1 407481179 13703082 1677040..1677342 1 NC_018658.1 COG0713 NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K); NADH:ubiquinone oxidoreductase subunit K 1677342 13703082 O3K_08105 Escherichia coli O104:H4 str. 2011C-3493 NADH:ubiquinone oxidoreductase subunit K YP_006778328.1 1677040 D 1133852 CDS YP_006778329.1 407481180 13703083 1677339..1679180 1 NC_018658.1 COG1009 NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit; NADH:ubiquinone oxidoreductase subunit L 1679180 13703083 O3K_08110 Escherichia coli O104:H4 str. 2011C-3493 NADH:ubiquinone oxidoreductase subunit L YP_006778329.1 1677339 D 1133852 CDS YP_006778330.1 407481181 13703084 1679344..1680873 1 NC_018658.1 COG1008 NADH:ubiquinone oxidoreductase subunit 4 (chain M); NADH:ubiquinone oxidoreductase subunit M 1680873 13703084 O3K_08115 Escherichia coli O104:H4 str. 2011C-3493 NADH:ubiquinone oxidoreductase subunit M YP_006778330.1 1679344 D 1133852 CDS YP_006778331.1 407481182 13703085 1680880..1682337 1 NC_018658.1 COG1007 NADH:ubiquinone oxidoreductase subunit 2 (chain N); NADH:ubiquinone oxidoreductase subunit N 1682337 13703085 O3K_08120 Escherichia coli O104:H4 str. 2011C-3493 NADH:ubiquinone oxidoreductase subunit N YP_006778331.1 1680880 D 1133852 CDS YP_006778332.1 407481183 13703086 complement(1682404..1682907) 1 NC_018658.1 hypothetical protein 1682907 13703086 O3K_08125 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778332.1 1682404 R 1133852 CDS YP_006778333.1 407481184 13703087 complement(1683033..1683212) 1 NC_018658.1 COG2234 Predicted aminopeptidases; Zn-dependent exopeptidase 1683212 13703087 O3K_08130 Escherichia coli O104:H4 str. 2011C-3493 Zn-dependent exopeptidase YP_006778333.1 1683033 R 1133852 CDS YP_006778334.1 407481185 13703088 complement(1685437..1686354) 1 NC_018658.1 COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III; ribonuclease Z 1686354 13703088 O3K_08145 Escherichia coli O104:H4 str. 2011C-3493 ribonuclease Z YP_006778334.1 1685437 R 1133852 CDS YP_006778335.1 407481186 13703089 1686419..1686880 1 NC_018658.1 COG2153 Predicted acyltransferase; putative acyltransferase 1686880 13703089 O3K_08150 Escherichia coli O104:H4 str. 2011C-3493 putative acyltransferase YP_006778335.1 1686419 D 1133852 CDS YP_006778336.1 407481187 13703090 1686935..1687240 1 NC_018658.1 COG4575 Uncharacterized conserved protein; hypothetical protein 1687240 13703090 O3K_08155 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778336.1 1686935 D 1133852 CDS YP_006778337.1 407481188 13703091 1687319..1688614 1 NC_018658.1 COG1169 Isochorismate synthase; menaquinone-specific isochorismate synthase 1688614 13703091 O3K_08160 Escherichia coli O104:H4 str. 2011C-3493 menaquinone-specific isochorismate synthase YP_006778337.1 1687319 D 1133852 CDS YP_006778338.1 407481189 13703092 1688703..1690373 1 NC_018658.1 COG1165 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase 1690373 13703092 O3K_08165 Escherichia coli O104:H4 str. 2011C-3493 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase YP_006778338.1 1688703 D 1133852 CDS YP_006778339.1 407481190 13703093 1690370..1691128 1 NC_018658.1 COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily); 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase 1691128 13703093 O3K_08170 Escherichia coli O104:H4 str. 2011C-3493 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase YP_006778339.1 1690370 D 1133852 CDS YP_006778340.1 407481191 13703094 1691143..1692000 1 NC_018658.1 COG0447 Dihydroxynaphthoic acid synthase; dihydroxynaphthoic acid synthetase 1692000 13703094 O3K_08175 Escherichia coli O104:H4 str. 2011C-3493 dihydroxynaphthoic acid synthetase YP_006778340.1 1691143 D 1133852 CDS YP_006778341.1 407481192 13703095 1692000..1692962 1 NC_018658.1 COG1441 O-succinylbenzoate synthase; O-succinylbenzoate synthase 1692962 13703095 O3K_08180 Escherichia coli O104:H4 str. 2011C-3493 O-succinylbenzoate synthase YP_006778341.1 1692000 D 1133852 CDS YP_006778342.1 407481193 13703096 1692959..1694314 1 NC_018658.1 COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II; O-succinylbenzoic acid--CoA ligase 1694314 13703096 O3K_08185 Escherichia coli O104:H4 str. 2011C-3493 O-succinylbenzoic acid--CoA ligase YP_006778342.1 1692959 D 1133852 CDS YP_006778343.1 407481194 13703097 1694424..1694690 1 NC_018658.1 COG1601 Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain; signal transduction protein PmrD 1694690 13703097 O3K_08190 Escherichia coli O104:H4 str. 2011C-3493 signal transduction protein PmrD YP_006778343.1 1694424 D 1133852 CDS YP_006778344.1 407481195 13703098 complement(1694684..1695070) 1 NC_018658.1 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF 1695070 13703098 O3K_08195 Escherichia coli O104:H4 str. 2011C-3493 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF YP_006778344.1 1694684 R 1133852 CDS YP_006778345.1 407481196 13703099 complement(1695070..1695405) 1 NC_018658.1 COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE 1695405 13703099 O3K_08200 Escherichia coli O104:H4 str. 2011C-3493 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE YP_006778345.1 1695070 R 1133852 CDS YP_006778346.1 407481197 13703100 complement(1695402..1697054) 1 NC_018658.1 COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family; 4-amino-4-deoxy-L-arabinose transferase 1697054 arnT 13703100 arnT Escherichia coli O104:H4 str. 2011C-3493 4-amino-4-deoxy-L-arabinose transferase YP_006778346.1 1695402 R 1133852 CDS YP_006778347.1 407481198 13703101 complement(1697054..1697944) 1 NC_018658.1 COG0726 Predicted xylanase/chitin deacetylase; 4-deoxy-4-formamido-L-arabinose- phosphoundecaprenol deformylase ArnD 1697944 13703101 O3K_08210 Escherichia coli O104:H4 str. 2011C-3493 4-deoxy-4-formamido-L-arabinose- phosphoundecaprenol deformylase ArnD YP_006778347.1 1697054 R 1133852 CDS YP_006778348.1 407481199 13703102 complement(1697941..1699923) 1 NC_018658.1 COG0223 Methionyl-tRNA formyltransferase; bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase 1699923 13703102 O3K_08215 Escherichia coli O104:H4 str. 2011C-3493 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase YP_006778348.1 1697941 R 1133852 CDS YP_006778349.1 407481200 13703103 complement(1699923..1700891) 1 NC_018658.1 COG0463 Glycosyltransferases involved in cell wall biogenesis; undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase 1700891 13703103 O3K_08220 Escherichia coli O104:H4 str. 2011C-3493 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase YP_006778349.1 1699923 R 1133852 CDS YP_006778350.1 407481201 13703104 complement(1700895..1702034) 1 NC_018658.1 COG0399 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis; UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase 1702034 13703104 O3K_08225 Escherichia coli O104:H4 str. 2011C-3493 UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase YP_006778350.1 1700895 R 1133852 CDS YP_006778351.1 407481202 13703105 1702342..1702944 1 NC_018658.1 lipopolysaccharide core heptose(II)-phosphate phosphatase 1702944 13703105 O3K_08230 Escherichia coli O104:H4 str. 2011C-3493 lipopolysaccharide core heptose(II)-phosphate phosphatase YP_006778351.1 1702342 D 1133852 CDS YP_006778352.1 407481203 13703106 complement(1702983..1703408) 1 NC_018658.1 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; nucleoside triphosphatase NudI 1703408 13703106 O3K_08235 Escherichia coli O104:H4 str. 2011C-3493 nucleoside triphosphatase NudI YP_006778352.1 1702983 R 1133852 CDS YP_006778353.1 407481204 13703107 1703687..1704229 1 NC_018658.1 putative outer membrane porin protein 1704229 13703107 O3K_08240 Escherichia coli O104:H4 str. 2011C-3493 putative outer membrane porin protein YP_006778353.1 1703687 D 1133852 CDS YP_006778354.1 407481205 13703108 1704329..1705531 1 NC_018658.1 COG1058 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA; hypothetical protein 1705531 13703108 O3K_08245 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778354.1 1704329 D 1133852 CDS YP_006778355.1 407481206 13703109 1705667..1706056 1 NC_018658.1 COG3836 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; 2-keto-3-deoxy-L-rhamnonate aldolase 1706056 13703109 O3K_08250 Escherichia coli O104:H4 str. 2011C-3493 2-keto-3-deoxy-L-rhamnonate aldolase YP_006778355.1 1705667 D 1133852 CDS YP_006778356.1 407481207 13703110 complement(1706097..1706999) 1 NC_018658.1 COG5464 Uncharacterized conserved protein; hypothetical protein 1706999 13703110 O3K_08255 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778356.1 1706097 R 1133852 CDS YP_006778357.1 407481208 13703111 complement(1707193..1708383) 1 NC_018658.1 COG0247 Fe-S oxidoreductase; sn-glycerol-3-phosphate dehydrogenase subunit C 1708383 glpC 13703111 glpC Escherichia coli O104:H4 str. 2011C-3493 sn-glycerol-3-phosphate dehydrogenase subunit C YP_006778357.1 1707193 R 1133852 CDS YP_006778358.1 407481209 13703112 complement(1708380..1709639) 1 NC_018658.1 COG3075 Anaerobic glycerol-3-phosphate dehydrogenase; anaerobic glycerol-3-phosphate dehydrogenase subunit B 1709639 13703112 O3K_08265 Escherichia coli O104:H4 str. 2011C-3493 anaerobic glycerol-3-phosphate dehydrogenase subunit B YP_006778358.1 1708380 R 1133852 CDS YP_006778359.1 407481210 13703113 complement(1709629..1711257) 1 NC_018658.1 COG0578 Glycerol-3-phosphate dehydrogenase; sn-glycerol-3-phosphate dehydrogenase subunit A 1711257 glpA 13703113 glpA Escherichia coli O104:H4 str. 2011C-3493 sn-glycerol-3-phosphate dehydrogenase subunit A YP_006778359.1 1709629 R 1133852 CDS YP_006778360.1 407481211 13703114 1711530..1712888 1 NC_018658.1 COG2271 Sugar phosphate permease; sn-glycerol-3-phosphate transporter 1712888 glpT 13703114 glpT Escherichia coli O104:H4 str. 2011C-3493 sn-glycerol-3-phosphate transporter YP_006778360.1 1711530 D 1133852 CDS YP_006778361.1 407481212 13703115 1712893..1713969 1 NC_018658.1 COG0584 Glycerophosphoryl diester phosphodiesterase; glycerophosphodiester phosphodiesterase 1713969 glpQ 13703115 glpQ Escherichia coli O104:H4 str. 2011C-3493 glycerophosphodiester phosphodiesterase YP_006778361.1 1712893 D 1133852 CDS YP_006778362.1 407481213 13703116 complement(1714011..1714217) 1 NC_018658.1 hypothetical protein 1714217 13703116 O3K_08285 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778362.1 1714011 R 1133852 CDS YP_006778363.1 407481214 13703117 1714398..1715378 1 NC_018658.1 COG3039 Transposase and inactivated derivatives, IS5 family; IS5 transposase and trans-activator 1715378 13703117 O3K_08290 Escherichia coli O104:H4 str. 2011C-3493 IS5 transposase and trans-activator YP_006778363.1 1714398 D 1133852 CDS YP_006778364.1 407481215 13703118 1715632..1716282 1 NC_018658.1 hypothetical protein 1716282 13703118 O3K_08295 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778364.1 1715632 D 1133852 CDS YP_006778365.1 407481216 13703119 complement(1716336..1716590) 1 NC_018658.1 COG0633 Ferredoxin; 2Fe-2S ferredoxin 1716590 13703119 O3K_08300 Escherichia coli O104:H4 str. 2011C-3493 2Fe-2S ferredoxin YP_006778365.1 1716336 R 1133852 CDS YP_006778366.1 407481217 13703120 complement(1716590..1717720) 1 NC_018658.1 COG0208 Ribonucleotide reductase, beta subunit; ribonucleotide-diphosphate reductase subunit beta 1717720 nrdB 13703120 nrdB Escherichia coli O104:H4 str. 2011C-3493 ribonucleotide-diphosphate reductase subunit beta YP_006778366.1 1716590 R 1133852 CDS YP_006778367.1 407481218 13703121 complement(1717809..1720094) 1 NC_018658.1 COG0209 Ribonucleotide reductase, alpha subunit; ribonucleotide-diphosphate reductase subunit alpha 1720094 13703121 O3K_08310 Escherichia coli O104:H4 str. 2011C-3493 ribonucleotide-diphosphate reductase subunit alpha YP_006778367.1 1717809 R 1133852 CDS YP_006778368.1 407481219 13703122 1720790..1724524 1 NC_018658.1 COG3468 Type V secretory pathway, adhesin AidA; adhesin 1724524 13703122 O3K_08315 Escherichia coli O104:H4 str. 2011C-3493 adhesin YP_006778368.1 1720790 D 1133852 CDS YP_006778369.1 407481220 13703123 complement(1724652..1725374) 1 NC_018658.1 COG2227 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase; bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase 1725374 13703123 O3K_08320 Escherichia coli O104:H4 str. 2011C-3493 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase YP_006778369.1 1724652 R 1133852 CDS YP_006778370.1 407481221 13703124 1725521..1728148 1 NC_018658.1 COG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit; DNA gyrase subunit A 1728148 13703124 O3K_08325 Escherichia coli O104:H4 str. 2011C-3493 DNA gyrase subunit A YP_006778370.1 1725521 D 1133852 CDS YP_006778371.1 407481222 13703125 1728297..1729985 1 NC_018658.1 COG4685 Uncharacterized protein conserved in bacteria; hypothetical protein 1729985 13703125 O3K_08330 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778371.1 1728297 D 1133852 CDS YP_006778372.1 407481223 13703126 1729982..1730605 1 NC_018658.1 COG3234 Uncharacterized protein conserved in bacteria; hypothetical protein 1730605 13703126 O3K_08335 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778372.1 1729982 D 1133852 CDS YP_006778373.1 407481224 13703127 1730539..1735143 1 NC_018658.1 COG2373 Large extracellular alpha-helical protein; alpha-2-macroglobulin family protein 1735143 13703127 O3K_08340 Escherichia coli O104:H4 str. 2011C-3493 alpha-2-macroglobulin family protein YP_006778373.1 1730539 D 1133852 CDS YP_006778374.1 407481225 13703128 1735144..1736793 1 NC_018658.1 COG5445 Predicted secreted protein; hypothetical protein 1736793 13703128 O3K_08345 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778374.1 1735144 D 1133852 CDS YP_006778375.1 407481226 13703129 1736798..1737574 1 NC_018658.1 COG4676 Uncharacterized protein conserved in bacteria; hypothetical protein 1737574 13703129 O3K_08350 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778375.1 1736798 D 1133852 CDS YP_006778376.1 407481227 13703130 1737849..1740698 1 NC_018658.1 COG0642 Signal transduction histidine kinase; hybrid sensory kinase in two-component regulatory system with RcsB and YojN 1740698 13703130 O3K_08355 Escherichia coli O104:H4 str. 2011C-3493 hybrid sensory kinase in two-component regulatory system with RcsB and YojN YP_006778376.1 1737849 D 1133852 CDS YP_006778377.1 407481228 13703131 complement(1740898..1741548) 1 NC_018658.1 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; transcriptional regulator RcsB 1741548 13703131 O3K_08360 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator RcsB YP_006778377.1 1740898 R 1133852 CDS YP_006778378.1 407481229 13703132 complement(1741565..1744237) 1 NC_018658.1 COG0642 Signal transduction histidine kinase; phosphotransfer intermediate protein in two-component regulatory system with RcsBC 1744237 13703132 O3K_08365 Escherichia coli O104:H4 str. 2011C-3493 phosphotransfer intermediate protein in two-component regulatory system with RcsBC YP_006778378.1 1741565 R 1133852 CDS YP_006778379.1 407481230 13703133 1744976..1746079 1 NC_018658.1 COG3203 Outer membrane protein (porin); outer membrane porin protein C 1746079 13703133 O3K_08370 Escherichia coli O104:H4 str. 2011C-3493 outer membrane porin protein C YP_006778379.1 1744976 D 1133852 CDS YP_006778380.1 407481231 13703134 1746191..1747246 1 NC_018658.1 COG1477 Membrane-associated lipoprotein involved in thiamine biosynthesis; thiamine biosynthesis lipoprotein ApbE 1747246 13703134 O3K_08375 Escherichia coli O104:H4 str. 2011C-3493 thiamine biosynthesis lipoprotein ApbE YP_006778380.1 1746191 D 1133852 CDS YP_006778381.1 407481232 13703135 1747320..1748384 1 NC_018658.1 COG2169 Adenosine deaminase; bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase 1748384 13703135 O3K_08380 Escherichia coli O104:H4 str. 2011C-3493 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase YP_006778381.1 1747320 D 1133852 CDS YP_006778382.1 407481233 13703136 1748384..1749034 1 NC_018658.1 COG3145 Alkylated DNA repair protein; alpha-ketoglutarate-dependent dioxygenase AlkB 1749034 13703136 O3K_08385 Escherichia coli O104:H4 str. 2011C-3493 alpha-ketoglutarate-dependent dioxygenase AlkB YP_006778382.1 1748384 D 1133852 CDS YP_006778383.1 407481234 13703137 1749110..1750753 1 NC_018658.1 COG4615 ABC-type siderophore export system, fused ATPase and permease components; multidrug transporter membrane protein/ATP-binding component 1750753 13703137 O3K_08390 Escherichia coli O104:H4 str. 2011C-3493 multidrug transporter membrane protein/ATP-binding component YP_006778383.1 1749110 D 1133852 CDS YP_006778384.1 407481235 13703138 1750971..1752617 1 NC_018658.1 COG0579 Predicted dehydrogenase; malate:quinone oxidoreductase 1752617 13703138 O3K_08395 Escherichia coli O104:H4 str. 2011C-3493 malate:quinone oxidoreductase YP_006778384.1 1750971 D 1133852 CDS YP_006778385.1 407481236 13703139 complement(1752766..1753254) 1 NC_018658.1 COG4574 Serine protease inhibitor ecotin; ecotin 1753254 13703139 O3K_08400 Escherichia coli O104:H4 str. 2011C-3493 ecotin YP_006778385.1 1752766 R 1133852 CDS YP_006778386.1 407481237 13703140 complement(1753389..1753562) 1 NC_018658.1 COG1626 Neutral trehalase; hypothetical protein 1753562 13703140 O3K_08405 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778386.1 1753389 R 1133852 CDS YP_006778387.1 407481238 13703141 1753662..1754156 1 NC_018658.1 COG1145 Ferredoxin; ferredoxin-type protein 1754156 13703141 O3K_08410 Escherichia coli O104:H4 str. 2011C-3493 ferredoxin-type protein YP_006778387.1 1753662 D 1133852 CDS YP_006778388.1 407481239 13703142 1754146..1754409 1 NC_018658.1 COG3062 Uncharacterized protein involved in formation of periplasmic nitrate reductase; assembly protein for periplasmic nitrate reductase 1754409 13703142 O3K_08415 Escherichia coli O104:H4 str. 2011C-3493 assembly protein for periplasmic nitrate reductase YP_006778388.1 1754146 D 1133852 CDS YP_006778389.1 407481240 13703143 1754406..1756892 1 NC_018658.1 COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; nitrate reductase catalytic subunit 1756892 13703143 O3K_08420 Escherichia coli O104:H4 str. 2011C-3493 nitrate reductase catalytic subunit YP_006778389.1 1754406 D 1133852 CDS YP_006778390.1 407481241 13703144 1756899..1757594 1 NC_018658.1 COG1145 Ferredoxin; quinol dehydrogenase periplasmic component 1757594 napG 13703144 napG Escherichia coli O104:H4 str. 2011C-3493 quinol dehydrogenase periplasmic component YP_006778390.1 1756899 D 1133852 CDS YP_006778391.1 407481242 13703145 1757581..1758444 1 NC_018658.1 COG0348 Polyferredoxin; quinol dehydrogenase membrane component 1758444 napH 13703145 napH Escherichia coli O104:H4 str. 2011C-3493 quinol dehydrogenase membrane component YP_006778391.1 1757581 D 1133852 CDS YP_006778392.1 407481243 13703146 1758441..1758890 1 NC_018658.1 COG3043 Nitrate reductase cytochrome c-type subunit; nitrate reductase cytochrome C550 subunit 1758890 napB 13703146 napB Escherichia coli O104:H4 str. 2011C-3493 nitrate reductase cytochrome C550 subunit YP_006778392.1 1758441 D 1133852 CDS YP_006778393.1 407481244 13703147 1758900..1759502 1 NC_018658.1 COG3005 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit; cytochrome c-type protein NapC 1759502 13703147 O3K_08440 Escherichia coli O104:H4 str. 2011C-3493 cytochrome c-type protein NapC YP_006778393.1 1758900 D 1133852 CDS YP_006778394.1 407481245 13703148 1759521..1760138 1 NC_018658.1 COG4133 ABC-type transport system involved in cytochrome c biogenesis, ATPase component; cytochrome c biogenesis protein CcmA 1760138 13703148 O3K_08445 Escherichia coli O104:H4 str. 2011C-3493 cytochrome c biogenesis protein CcmA YP_006778394.1 1759521 D 1133852 CDS YP_006778395.1 407481246 13703149 1760135..1760797 1 NC_018658.1 COG2386 ABC-type transport system involved in cytochrome c biogenesis, permease component; Heme exporter protein B 1760797 13703149 O3K_08450 Escherichia coli O104:H4 str. 2011C-3493 Heme exporter protein B YP_006778395.1 1760135 D 1133852 CDS YP_006778396.1 407481247 13703150 1760839..1761576 1 NC_018658.1 COG0755 ABC-type transport system involved in cytochrome c biogenesis, permease component; heme exporter protein C 1761576 13703150 O3K_08455 Escherichia coli O104:H4 str. 2011C-3493 heme exporter protein C YP_006778396.1 1760839 D 1133852 CDS YP_006778397.1 407481248 13703151 1761573..1761782 1 NC_018658.1 COG3114 Heme exporter protein D; cytochrome c biogenesis protein CcmD 1761782 13703151 O3K_08460 Escherichia coli O104:H4 str. 2011C-3493 cytochrome c biogenesis protein CcmD YP_006778397.1 1761573 D 1133852 CDS YP_006778398.1 407481249 13703152 1761779..1762258 1 NC_018658.1 COG2332 Cytochrome c-type biogenesis protein CcmE; cytochrome c-type biogenesis protein CcmE 1762258 13703152 O3K_08465 Escherichia coli O104:H4 str. 2011C-3493 cytochrome c-type biogenesis protein CcmE YP_006778398.1 1761779 D 1133852 CDS YP_006778399.1 407481250 13703153 1762255..1764198 1 NC_018658.1 COG1138 Cytochrome c biogenesis factor; heme lyase, CcmF subunit 1764198 13703153 O3K_08470 Escherichia coli O104:H4 str. 2011C-3493 heme lyase, CcmF subunit YP_006778399.1 1762255 D 1133852 CDS YP_006778400.1 407481251 13703154 1764195..1764752 1 NC_018658.1 COG0526 Thiol-disulfide isomerase and thioredoxins; thiol:disulfide interchange protein DsbE 1764752 13703154 O3K_08475 Escherichia coli O104:H4 str. 2011C-3493 thiol:disulfide interchange protein DsbE YP_006778400.1 1764195 D 1133852 CDS YP_006778401.1 407481252 13703155 1764749..1765801 1 NC_018658.1 COG3088 Uncharacterized protein involved in biosynthesis of c-type cytochromes; heme lyase, CcmH subunit 1765801 13703155 O3K_08480 Escherichia coli O104:H4 str. 2011C-3493 heme lyase, CcmH subunit YP_006778401.1 1764749 D 1133852 CDS YP_006778402.1 407481253 13703156 complement(1765836..1766483) 1 NC_018658.1 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; transcriptional regulator NarP 1766483 13703156 O3K_08485 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator NarP YP_006778402.1 1765836 R 1133852 CDS YP_006778403.1 407481254 13703157 1766884..1769169 1 NC_018658.1 COG3468 Type V secretory pathway, adhesin AidA; putative autotransporter 1769169 13703157 O3K_08490 Escherichia coli O104:H4 str. 2011C-3493 putative autotransporter YP_006778403.1 1766884 D 1133852 CDS YP_006778404.1 407481255 13703158 1769182..1769394 1 NC_018658.1 autotransporter outer membrane protein 1769394 13703158 O3K_08495 Escherichia coli O104:H4 str. 2011C-3493 autotransporter outer membrane protein YP_006778404.1 1769182 D 1133852 CDS YP_006778405.1 407481256 13703160 complement(1769648..1771408) 1 NC_018658.1 COG3083 Predicted hydrolase of alkaline phosphatase superfamily; putative hydrolase, inner membrane 1771408 13703160 O3K_08500 Escherichia coli O104:H4 str. 2011C-3493 putative hydrolase, inner membrane YP_006778405.1 1769648 R 1133852 CDS YP_006778406.1 407481257 13703161 complement(1771428..1771655) 1 NC_018658.1 COG3082 Uncharacterized protein conserved in bacteria; hypothetical protein 1771655 13703161 O3K_08505 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778406.1 1771428 R 1133852 CDS YP_006778407.1 407481258 13703162 1771837..1772844 1 NC_018658.1 COG3081 Nucleoid-associated protein; nucleoid-associated protein NdpA 1772844 13703162 O3K_08510 Escherichia coli O104:H4 str. 2011C-3493 nucleoid-associated protein NdpA YP_006778407.1 1771837 D 1133852 CDS YP_006778408.1 407481259 13703163 complement(1772983..1773267) 1 NC_018658.1 COG1825 Ribosomal protein L25 (general stress protein Ctc); 50S ribosomal protein L25 1773267 13703163 O3K_08515 Escherichia coli O104:H4 str. 2011C-3493 50S ribosomal protein L25 YP_006778408.1 1772983 R 1133852 CDS YP_006778409.1 407481260 13703164 complement(1773392..1775152) 1 NC_018658.1 COG1061 DNA or RNA helicases of superfamily II; nucleic acid ATP-dependent helicase 1775152 13703164 O3K_08520 Escherichia coli O104:H4 str. 2011C-3493 nucleic acid ATP-dependent helicase YP_006778409.1 1773392 R 1133852 CDS YP_006778410.1 407481261 13703165 1775301..1775996 1 NC_018658.1 COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases; 16S rRNA pseudouridylate synthase A 1775996 13703165 O3K_08525 Escherichia coli O104:H4 str. 2011C-3493 16S rRNA pseudouridylate synthase A YP_006778410.1 1775301 D 1133852 CDS YP_006778411.1 407481262 13703166 1776024..1777214 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; bicyclomycin/multidrug efflux system protein 1777214 13703166 O3K_08530 Escherichia coli O104:H4 str. 2011C-3493 bicyclomycin/multidrug efflux system protein YP_006778411.1 1776024 D 1133852 CDS YP_006778412.1 407481263 13703167 1777547..1777891 1 NC_018658.1 hypothetical protein 1777891 13703167 O3K_08535 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778412.1 1777547 D 1133852 CDS YP_006778413.1 407481264 13703168 complement(1777895..1779484) 1 NC_018658.1 COG4172 ABC-type uncharacterized transport system, duplicated ATPase component; microcin C ABC transporter ATP-binding protein YejF 1779484 13703168 O3K_08540 Escherichia coli O104:H4 str. 2011C-3493 microcin C ABC transporter ATP-binding protein YejF YP_006778413.1 1777895 R 1133852 CDS YP_006778414.1 407481265 13703169 complement(1779486..1780511) 1 NC_018658.1 COG4239 ABC-type uncharacterized transport system, permease component; microcin C ABC transporter permease 1780511 13703169 O3K_08545 Escherichia coli O104:H4 str. 2011C-3493 microcin C ABC transporter permease YP_006778414.1 1779486 R 1133852 CDS YP_006778415.1 407481266 13703170 complement(1780511..1781605) 1 NC_018658.1 COG4174 ABC-type uncharacterized transport system, permease component; microcin C ABC transporter permease YejB 1781605 13703170 O3K_08550 Escherichia coli O104:H4 str. 2011C-3493 microcin C ABC transporter permease YejB YP_006778415.1 1780511 R 1133852 CDS YP_006778416.1 407481267 13703171 complement(1781606..1783420) 1 NC_018658.1 COG4166 ABC-type oligopeptide transport system, periplasmic component; oligopeptide ABC transporter substrate-binding protein 1783420 13703171 O3K_08555 Escherichia coli O104:H4 str. 2011C-3493 oligopeptide ABC transporter substrate-binding protein YP_006778416.1 1781606 R 1133852 CDS YP_006778417.1 407481268 13703172 complement(1783502..1785058) 1 NC_018658.1 COG2200 FOG: EAL domain; phage resistance protein 1785058 13703172 O3K_08560 Escherichia coli O104:H4 str. 2011C-3493 phage resistance protein YP_006778417.1 1783502 R 1133852 CDS YP_006778418.1 407481269 13703173 complement(1785239..1785805) 1 NC_018658.1 COG0791 Cell wall-associated hydrolases (invasion-associated proteins); outer membrane lipoprotein 1785805 spr 13703173 spr Escherichia coli O104:H4 str. 2011C-3493 outer membrane lipoprotein YP_006778418.1 1785239 R 1133852 CDS YP_006778419.1 407481270 13703174 complement(1786217..1786930) 1 NC_018658.1 COG0671 Membrane-associated phospholipid phosphatase; hypothetical protein 1786930 13703174 O3K_08570 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778419.1 1786217 R 1133852 CDS YP_006778420.1 407481271 13703175 complement(1786969..1787955) 1 NC_018658.1 COG0523 Putative GTPases (G3E family); hypothetical protein 1787955 13703175 O3K_08575 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778420.1 1786969 R 1133852 CDS YP_006778421.1 407481272 13703176 complement(1788073..1789539) 1 NC_018658.1 COG0246 Mannitol-1-phosphate/altronate dehydrogenases; sugar dehydrogenase, NAD-dependent 1789539 13703176 O3K_08580 Escherichia coli O104:H4 str. 2011C-3493 sugar dehydrogenase, NAD-dependent YP_006778421.1 1788073 R 1133852 CDS YP_006778422.1 407481273 13703177 complement(1789762..1790334) 1 NC_018658.1 COG0231 Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A); elongation factor P 1790334 13703177 O3K_08585 Escherichia coli O104:H4 str. 2011C-3493 elongation factor P YP_006778422.1 1789762 R 1133852 CDS YP_006778423.1 407481274 13703178 1790489..1790743 1 NC_018658.1 COG0727 Predicted Fe-S-cluster oxidoreductase; hypothetical protein 1790743 13703178 O3K_08590 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778423.1 1790489 D 1133852 CDS YP_006778424.1 407481275 13703179 complement(1790740..1791921) 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; sugar efflux transporter B 1791921 13703179 O3K_08595 Escherichia coli O104:H4 str. 2011C-3493 sugar efflux transporter B YP_006778424.1 1790740 R 1133852 CDS YP_006778425.1 407481276 13703180 1792289..1793419 1 NC_018658.1 COG4668 Mannitol/fructose-specific phosphotransferase system, IIA domain; PTS system fructose-specific transporter subunit IIA/HPr protein 1793419 13703180 O3K_08600 Escherichia coli O104:H4 str. 2011C-3493 PTS system fructose-specific transporter subunit IIA/HPr protein YP_006778425.1 1792289 D 1133852 CDS YP_006778426.1 407481277 13703181 1793419..1794357 1 NC_018658.1 COG1105 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB); 1-phosphofructokinase 1794357 fruK 13703181 fruK Escherichia coli O104:H4 str. 2011C-3493 1-phosphofructokinase YP_006778426.1 1793419 D 1133852 CDS YP_006778427.1 407481278 13703182 1794374..1796065 1 NC_018658.1 COG3925 N-terminal domain of the phosphotransferase system fructose-specific component IIB; PTS system fructose-specific transporter subunit IIBC 1796065 13703182 O3K_08610 Escherichia coli O104:H4 str. 2011C-3493 PTS system fructose-specific transporter subunit IIBC YP_006778427.1 1794374 D 1133852 CDS YP_006778428.1 407481279 13703183 1796489..1797430 1 NC_018658.1 COG0524 Sugar kinases, ribokinase family; pseudouridine kinase 1797430 13703183 O3K_08615 Escherichia coli O104:H4 str. 2011C-3493 pseudouridine kinase YP_006778428.1 1796489 D 1133852 CDS YP_006778429.1 407481280 13703184 1797418..1798356 1 NC_018658.1 COG2313 Uncharacterized enzyme involved in pigment biosynthesis; hypothetical protein 1798356 13703184 O3K_08620 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778429.1 1797418 D 1133852 CDS YP_006778430.1 407481281 13703185 1798450..1799700 1 NC_018658.1 COG1972 Nucleoside permease; sodium/proton nucleoside transporter 1799700 13703185 O3K_08625 Escherichia coli O104:H4 str. 2011C-3493 sodium/proton nucleoside transporter YP_006778430.1 1798450 D 1133852 CDS YP_006778431.1 407481282 13703186 complement(1799768..1800427) 1 NC_018658.1 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases; DNA-binding transcriptional activator YeiL 1800427 13703186 O3K_08630 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional activator YeiL YP_006778431.1 1799768 R 1133852 CDS YP_006778432.1 407481283 13703187 1800596..1801537 1 NC_018658.1 COG1957 Inosine-uridine nucleoside N-ribohydrolase; ribonucleoside hydrolase 2 1801537 rihB 13703187 rihB Escherichia coli O104:H4 str. 2011C-3493 ribonucleoside hydrolase 2 YP_006778432.1 1800596 D 1133852 CDS YP_006778433.1 407481284 13703188 1801637..1802887 1 NC_018658.1 COG1972 Nucleoside permease; nucleoside transporter 1802887 13703188 O3K_08640 Escherichia coli O104:H4 str. 2011C-3493 nucleoside transporter YP_006778433.1 1801637 D 1133852 CDS YP_006778434.1 407481285 13703189 complement(1802943..1804031) 1 NC_018658.1 COG2771 DNA-binding HTH domain-containing proteins; putative kinase 1804031 13703189 O3K_08645 Escherichia coli O104:H4 str. 2011C-3493 putative kinase YP_006778434.1 1802943 R 1133852 CDS YP_006778435.1 407481286 13703190 complement(1804035..1804892) 1 NC_018658.1 COG0648 Endonuclease IV; endonuclease IV 1804892 13703190 O3K_08650 Escherichia coli O104:H4 str. 2011C-3493 endonuclease IV YP_006778435.1 1804035 R 1133852 CDS YP_006778436.1 407481287 13703191 complement(1804966..1806015) 1 NC_018658.1 COG2855 Predicted membrane protein; hypothetical protein 1806015 13703191 O3K_08655 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778436.1 1804966 R 1133852 CDS YP_006778437.1 407481288 13703192 1806114..1806995 1 NC_018658.1 COG0583 Transcriptional regulator; putative DNA-binding transcriptional regulator 1806995 13703192 O3K_08660 Escherichia coli O104:H4 str. 2011C-3493 putative DNA-binding transcriptional regulator YP_006778437.1 1806114 D 1133852 CDS YP_006778438.1 407481289 13703193 1807200..1808669 1 NC_018658.1 COG0833 Amino acid transporters; lysine transporter 1808669 13703193 O3K_08665 Escherichia coli O104:H4 str. 2011C-3493 lysine transporter YP_006778438.1 1807200 D 1133852 CDS YP_006778439.1 407481290 13703194 1808962..1810953 1 NC_018658.1 COG4771 Outer membrane receptor for ferrienterochelin and colicins; catecholate siderophore receptor CirA 1810953 13703194 O3K_08670 Escherichia coli O104:H4 str. 2011C-3493 catecholate siderophore receptor CirA YP_006778439.1 1808962 D 1133852 CDS YP_006778440.1 407481291 13703195 complement(1810985..1811821) 1 NC_018658.1 COG0627 Predicted esterase; esterase 1811821 13703195 O3K_08675 Escherichia coli O104:H4 str. 2011C-3493 esterase YP_006778440.1 1810985 R 1133852 CDS YP_006778441.1 407481292 13703196 1812079..1812747 1 NC_018658.1 COG0302 GTP cyclohydrolase I; GTP cyclohydrolase I 1812747 folE 13703196 folE Escherichia coli O104:H4 str. 2011C-3493 GTP cyclohydrolase I YP_006778441.1 1812079 D 1133852 CDS YP_006778442.1 407481293 13703197 1812764..1813921 1 NC_018658.1 COG2311 Predicted membrane protein; hypothetical protein 1813921 13703197 O3K_08685 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778442.1 1812764 D 1133852 CDS YP_006778443.1 407481294 13703198 1814063..1815103 1 NC_018658.1 COG1609 Transcriptional regulators; DNA-binding transcriptional regulator GalS 1815103 13703198 O3K_08690 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator GalS YP_006778443.1 1814063 D 1133852 CDS YP_006778444.1 407481295 13703199 1815383..1816381 1 NC_018658.1 COG1879 ABC-type sugar transport system, periplasmic component; methyl-galactoside ABC transporter substrate-binding protein MglB 1816381 13703199 O3K_08695 Escherichia coli O104:H4 str. 2011C-3493 methyl-galactoside ABC transporter substrate-binding protein MglB YP_006778444.1 1815383 D 1133852 CDS YP_006778445.1 407481296 13703200 1816442..1817962 1 NC_018658.1 COG1129 ABC-type sugar transport system, ATPase component; galactose/methyl galaxtoside transporter ATP-binding protein 1817962 13703200 O3K_08700 Escherichia coli O104:H4 str. 2011C-3493 galactose/methyl galaxtoside transporter ATP-binding protein YP_006778445.1 1816442 D 1133852 CDS YP_006778446.1 407481297 13703201 1817978..1818988 1 NC_018658.1 COG4211 ABC-type glucose/galactose transport system, permease component; beta-methylgalactoside transporter inner membrane protein 1818988 mglC 13703201 mglC Escherichia coli O104:H4 str. 2011C-3493 beta-methylgalactoside transporter inner membrane protein YP_006778446.1 1817978 D 1133852 CDS YP_006778447.1 407481298 13703202 complement(1819059..1820294) 1 NC_018658.1 COG0167 Dihydroorotate dehydrogenase; dihydropyrimidine dehydrogenase subunit B 1820294 13703202 O3K_08710 Escherichia coli O104:H4 str. 2011C-3493 dihydropyrimidine dehydrogenase subunit B YP_006778447.1 1819059 R 1133852 CDS YP_006778448.1 407481299 13703203 complement(1820288..1821526) 1 NC_018658.1 COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases; dihydropyrimidine dehydrogenase subunit A 1821526 13703203 O3K_08715 Escherichia coli O104:H4 str. 2011C-3493 dihydropyrimidine dehydrogenase subunit A YP_006778448.1 1820288 R 1133852 CDS YP_006778449.1 407481300 13703204 complement(1821845..1822084) 1 NC_018658.1 hypothetical protein 1822084 13703204 O3K_08720 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778449.1 1821845 R 1133852 CDS YP_006778450.1 407481301 13703205 complement(1822087..1822806) 1 NC_018658.1 COG2949 Uncharacterized membrane protein; vancomycin high temperature exclusion protein 1822806 13703205 O3K_08725 Escherichia coli O104:H4 str. 2011C-3493 vancomycin high temperature exclusion protein YP_006778450.1 1822087 R 1133852 CDS YP_006778451.1 407481302 13703206 complement(1822956..1823840) 1 NC_018658.1 COG0295 Cytidine deaminase; cytidine deaminase 1823840 13703206 O3K_08730 Escherichia coli O104:H4 str. 2011C-3493 cytidine deaminase YP_006778451.1 1822956 R 1133852 CDS YP_006778452.1 407481303 13703207 complement(1823970..1824665) 1 NC_018658.1 COG1346 Putative effector of murein hydrolase; hypothetical protein 1824665 13703207 O3K_08735 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778452.1 1823970 R 1133852 CDS YP_006778453.1 407481304 13703208 complement(1824662..1825060) 1 NC_018658.1 COG1380 Putative effector of murein hydrolase LrgA; hypothetical protein 1825060 13703208 O3K_08740 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778453.1 1824662 R 1133852 CDS YP_006778454.1 407481305 13703209 1825299..1826246 1 NC_018658.1 COG0042 tRNA-dihydrouridine synthase; tRNA-dihydrouridine synthase C 1826246 13703209 O3K_08745 Escherichia coli O104:H4 str. 2011C-3493 tRNA-dihydrouridine synthase C YP_006778454.1 1825299 D 1133852 CDS YP_006778455.1 407481306 13703210 complement(1826619..1826702) 1 NC_018658.1 hypothetical protein 1826702 13703210 O3K_08750 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778455.1 1826619 R 1133852 CDS YP_006778456.1 407481307 13703211 1826926..1828362 1 NC_018658.1 COG1538 Outer membrane protein; multidrug resistance outer membrane protein MdtQ 1828362 13703211 O3K_08755 Escherichia coli O104:H4 str. 2011C-3493 multidrug resistance outer membrane protein MdtQ YP_006778456.1 1826926 D 1133852 CDS YP_006778457.1 407481308 13703212 1828415..1829176 1 NC_018658.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); oxidoreductase 1829176 13703212 O3K_08760 Escherichia coli O104:H4 str. 2011C-3493 oxidoreductase YP_006778457.1 1828415 D 1133852 CDS YP_006778458.1 407481309 13703213 complement(1829306..1829884) 1 NC_018658.1 COG0586 Uncharacterized membrane-associated protein; inner membrane protein 1829884 13703213 O3K_08765 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006778458.1 1829306 R 1133852 CDS YP_006778459.1 407481310 13703214 1830054..1830641 1 NC_018658.1 inner membrane protein YohC 1830641 13703214 O3K_08770 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YohC YP_006778459.1 1830054 D 1133852 CDS YP_006778460.1 407481311 13703215 1830815..1831747 1 NC_018658.1 COG1686 D-alanyl-D-alanine carboxypeptidase; D-alanyl-D-alanine endopeptidase 1831747 pbpG 13703215 pbpG Escherichia coli O104:H4 str. 2011C-3493 D-alanyl-D-alanine endopeptidase YP_006778460.1 1830815 D 1133852 CDS YP_006778461.1 407481312 13703216 complement(1831785..1833500) 1 NC_018658.1 COG0277 FAD/FMN-containing dehydrogenases; D-lactate dehydrogenase 1833500 13703216 O3K_08780 Escherichia coli O104:H4 str. 2011C-3493 D-lactate dehydrogenase YP_006778461.1 1831785 R 1133852 CDS YP_006778462.1 407481313 13703217 1833696..1835993 1 NC_018658.1 COG1472 Beta-glucosidase-related glycosidases; beta-D-glucoside glucohydrolase 1835993 13703217 O3K_08785 Escherichia coli O104:H4 str. 2011C-3493 beta-D-glucoside glucohydrolase YP_006778462.1 1833696 D 1133852 CDS YP_006778463.1 407481314 13703218 1836204..1837121 1 NC_018658.1 COG1732 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein); transporter subunit 1837121 13703218 O3K_08790 Escherichia coli O104:H4 str. 2011C-3493 transporter subunit YP_006778463.1 1836204 D 1133852 CDS YP_006778464.1 407481315 13703219 1837128..1838285 1 NC_018658.1 COG1174 ABC-type proline/glycine betaine transport systems, permease component; transporter subunit 1838285 13703219 O3K_08795 Escherichia coli O104:H4 str. 2011C-3493 transporter subunit YP_006778464.1 1837128 D 1133852 CDS YP_006778465.1 407481316 13703220 1838278..1839204 1 NC_018658.1 COG1125 ABC-type proline/glycine betaine transport systems, ATPase components; ABC transporter ATP-binding protein 1839204 13703220 O3K_08800 Escherichia coli O104:H4 str. 2011C-3493 ABC transporter ATP-binding protein YP_006778465.1 1838278 D 1133852 CDS YP_006778466.1 407481317 13703221 1839209..1839940 1 NC_018658.1 COG1174 ABC-type proline/glycine betaine transport systems, permease component; ABC transporter quaternary amine uptake (QAT) family, permease 1839940 13703221 O3K_08805 Escherichia coli O104:H4 str. 2011C-3493 ABC transporter quaternary amine uptake (QAT) family, permease YP_006778466.1 1839209 D 1133852 CDS YP_006778467.1 407481318 13703222 complement(1839921..1840028) 1 NC_018658.1 hypothetical protein 1840028 13703222 O3K_08810 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778467.1 1839921 R 1133852 CDS YP_006778468.1 407481319 13703223 complement(1840088..1840819) 1 NC_018658.1 COG0789 Predicted transcriptional regulators; transcriptional regulator MirA 1840819 13703223 O3K_08815 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator MirA YP_006778468.1 1840088 R 1133852 CDS YP_006778469.1 407481320 13699293 1841041..1842726 1 NC_018658.1 COG3275 Putative regulator of cell autolysis; putative sensory kinase in two-component system with YehT 1842726 13699293 O3K_08820 Escherichia coli O104:H4 str. 2011C-3493 putative sensory kinase in two-component system with YehT YP_006778469.1 1841041 D 1133852 CDS YP_006778470.1 407481321 13699294 1842723..1843442 1 NC_018658.1 COG3279 Response regulator of the LytR/AlgR family; putative two-component response-regulatory protein YehT 1843442 13699294 O3K_08825 Escherichia coli O104:H4 str. 2011C-3493 putative two-component response-regulatory protein YehT YP_006778470.1 1842723 D 1133852 CDS YP_006778471.1 407481322 13699295 1843489..1843959 1 NC_018658.1 COG4807 Uncharacterized protein conserved in bacteria; hypothetical protein 1843959 13699295 O3K_08830 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778471.1 1843489 D 1133852 CDS YP_006778472.1 407481323 13699296 complement(1844000..1844461) 1 NC_018658.1 COG4808 Uncharacterized protein conserved in bacteria; hypothetical protein 1844461 13699296 O3K_08835 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778472.1 1844000 R 1133852 CDS YP_006778473.1 407481324 13699297 complement(1844586..1846586) 1 NC_018658.1 hypothetical protein 1846586 13699297 O3K_08840 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778473.1 1844586 R 1133852 CDS YP_006778474.1 407481325 13699298 complement(1846583..1847719) 1 NC_018658.1 hypothetical protein 1847719 13699298 O3K_08845 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778474.1 1846583 R 1133852 CDS YP_006778475.1 407481326 13699299 complement(1847712..1849991) 1 NC_018658.1 hypothetical protein 1849991 13699299 O3K_08850 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778475.1 1847712 R 1133852 CDS YP_006778476.1 407481327 13699300 complement(1850002..1851090) 1 NC_018658.1 COG0714 MoxR-like ATPases; putative transporter subunit 1851090 13699300 O3K_08855 Escherichia coli O104:H4 str. 2011C-3493 putative transporter subunit YP_006778476.1 1850002 R 1133852 CDS YP_006778477.1 407481328 13699301 1852131..1852220 1 NC_018658.1 hypothetical protein 1852220 13699301 O3K_08860 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778477.1 1852131 D 1133852 CDS YP_006778478.1 407481329 13699302 complement(1852708..1856340) 1 NC_018658.1 hypothetical protein 1856340 13699302 O3K_08865 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778478.1 1852708 R 1133852 CDS YP_006778479.1 407481330 13699303 complement(1856350..1860144) 1 NC_018658.1 COG3831 Uncharacterized conserved protein; hypothetical protein 1860144 13699303 O3K_08870 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778479.1 1856350 R 1133852 CDS YP_006778480.1 407481331 13699304 complement(1860285..1862318) 1 NC_018658.1 COG0143 Methionyl-tRNA synthetase; methionyl-tRNA synthetase 1862318 metG 13699304 metG Escherichia coli O104:H4 str. 2011C-3493 methionyl-tRNA synthetase YP_006778480.1 1860285 R 1133852 CDS YP_006778481.1 407481332 13699305 1862450..1863559 1 NC_018658.1 COG0489 ATPases involved in chromosome partitioning; antiporter inner membrane protein 1863559 13699305 O3K_08880 Escherichia coli O104:H4 str. 2011C-3493 antiporter inner membrane protein YP_006778481.1 1862450 D 1133852 CDS YP_006778482.1 407481333 13699306 1863942..1864103 1 NC_018658.1 hypothetical protein 1864103 13699306 O3K_08885 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778482.1 1863942 D 1133852 CDS YP_006778483.1 407481334 13699307 1864396..1864938 1 NC_018658.1 COG3539 P pilus assembly protein, pilin FimA; fimbrial-like protein 1864938 13699307 O3K_08890 Escherichia coli O104:H4 str. 2011C-3493 fimbrial-like protein YP_006778483.1 1864396 D 1133852 CDS YP_006778484.1 407481335 13699308 1865019..1865693 1 NC_018658.1 COG3121 P pilus assembly protein, chaperone PapD; membrane-associated pilin chaperone 1865693 13699308 O3K_08895 Escherichia coli O104:H4 str. 2011C-3493 membrane-associated pilin chaperone YP_006778484.1 1865019 D 1133852 CDS YP_006778485.1 407481336 13699309 1865709..1868189 1 NC_018658.1 COG3188 P pilus assembly protein, porin PapC; fimbrial outer membrane usher protein 1868189 13699309 O3K_08900 Escherichia coli O104:H4 str. 2011C-3493 fimbrial outer membrane usher protein YP_006778485.1 1865709 D 1133852 CDS YP_006778486.1 407481337 13699310 1868205..1869239 1 NC_018658.1 putative fimbrial-like adhesin protein StcD 1869239 13699310 O3K_08905 Escherichia coli O104:H4 str. 2011C-3493 putative fimbrial-like adhesin protein StcD YP_006778486.1 1868205 D 1133852 CDS YP_006778487.1 407481338 13699311 complement(1869321..1869659) 1 NC_018658.1 COG5455 Predicted integral membrane protein; hypothetical protein 1869659 13699311 O3K_08910 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778487.1 1869321 R 1133852 CDS YP_006778488.1 407481339 13699312 complement(1869878..1870702) 1 NC_018658.1 COG2215 ABC-type uncharacterized transport system, permease component; nickel/cobalt efflux protein RcnA 1870702 13699312 O3K_08915 Escherichia coli O104:H4 str. 2011C-3493 nickel/cobalt efflux protein RcnA YP_006778488.1 1869878 R 1133852 CDS YP_006778489.1 407481340 13699313 1870823..1871095 1 NC_018658.1 COG1937 Uncharacterized protein conserved in bacteria; transcriptional repressor RcnR to maintain nickel and cobalt homeostasis 1871095 13699313 O3K_08920 Escherichia coli O104:H4 str. 2011C-3493 transcriptional repressor RcnR to maintain nickel and cobalt homeostasis YP_006778489.1 1870823 D 1133852 CDS YP_006778490.1 407481341 13699314 1871318..1872106 1 NC_018658.1 COG2145 Hydroxyethylthiazole kinase, sugar kinase family; hydroxyethylthiazole kinase 1872106 13699314 O3K_08925 Escherichia coli O104:H4 str. 2011C-3493 hydroxyethylthiazole kinase YP_006778490.1 1871318 D 1133852 CDS YP_006778491.1 407481342 13699315 1872103..1872903 1 NC_018658.1 COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase 1872903 13699315 O3K_08930 Escherichia coli O104:H4 str. 2011C-3493 bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase YP_006778491.1 1872103 D 1133852 CDS YP_006778492.1 407481343 13699316 1872968..1873786 1 NC_018658.1 COG3757 Lyzozyme M1 (1,4-beta-N-acetylmuramidase); hydrolase 1873786 13699316 O3K_08935 Escherichia coli O104:H4 str. 2011C-3493 hydrolase YP_006778492.1 1872968 D 1133852 CDS YP_006778493.1 407481344 13699317 1873838..1874584 1 NC_018658.1 COG2188 Transcriptional regulators; GntR family transcriptional regulator 1874584 13699317 O3K_08940 Escherichia coli O104:H4 str. 2011C-3493 GntR family transcriptional regulator YP_006778493.1 1873838 D 1133852 CDS YP_006778494.1 407481345 13699318 complement(1874558..1875523) 1 NC_018658.1 COG0524 Sugar kinases, ribokinase family; kinase 1875523 13699318 O3K_08945 Escherichia coli O104:H4 str. 2011C-3493 kinase YP_006778494.1 1874558 R 1133852 CDS YP_006778495.1 407481346 13699319 complement(1875520..1876524) 1 NC_018658.1 COG1397 ADP-ribosylglycohydrolase; (phospho)hydrolase 1876524 13699319 O3K_08950 Escherichia coli O104:H4 str. 2011C-3493 (phospho)hydrolase YP_006778495.1 1875520 R 1133852 CDS YP_006778496.1 407481347 13699320 complement(1876521..1877798) 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; putative nucleoside transporter 1877798 13699320 O3K_08955 Escherichia coli O104:H4 str. 2011C-3493 putative nucleoside transporter YP_006778496.1 1876521 R 1133852 CDS YP_006778497.1 407481348 13699321 1878055..1879107 1 NC_018658.1 COG1830 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes; fructose-bisphosphate aldolase 1879107 13699321 O3K_08960 Escherichia coli O104:H4 str. 2011C-3493 fructose-bisphosphate aldolase YP_006778497.1 1878055 D 1133852 CDS YP_006778498.1 407481349 13699322 1879417..1880271 1 NC_018658.1 COG0191 Fructose/tagatose bisphosphate aldolase; tagatose-bisphosphate aldolase 1880271 gatY 13699322 gatY Escherichia coli O104:H4 str. 2011C-3493 tagatose-bisphosphate aldolase YP_006778498.1 1879417 D 1133852 CDS YP_006778499.1 407481350 13699323 1881567..1882019 1 NC_018658.1 COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type); PTS system galactitol-specific transporter subunit IIA 1882019 13699323 O3K_08980 Escherichia coli O104:H4 str. 2011C-3493 PTS system galactitol-specific transporter subunit IIA YP_006778499.1 1881567 D 1133852 CDS YP_006778500.1 407481351 13699324 1882050..1882334 1 NC_018658.1 COG3414 Phosphotransferase system, galactitol-specific IIB component; PTS system galactitol-specific transporter subunit IIB 1882334 13699324 O3K_08985 Escherichia coli O104:H4 str. 2011C-3493 PTS system galactitol-specific transporter subunit IIB YP_006778500.1 1882050 D 1133852 CDS YP_006778501.1 407481352 13699325 1882338..1883693 1 NC_018658.1 COG3775 Phosphotransferase system, galactitol-specific IIC component; PTS system galactitol-specific transporter subunit IIC 1883693 13699325 O3K_08990 Escherichia coli O104:H4 str. 2011C-3493 PTS system galactitol-specific transporter subunit IIC YP_006778501.1 1882338 D 1133852 CDS YP_006778502.1 407481353 13699326 1883741..1884781 1 NC_018658.1 COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases; galactitol-1-phosphate dehydrogenase 1884781 13699326 O3K_08995 Escherichia coli O104:H4 str. 2011C-3493 galactitol-1-phosphate dehydrogenase YP_006778502.1 1883741 D 1133852 CDS YP_006778503.1 407481354 13699327 1884887..1885660 1 NC_018658.1 COG1349 Transcriptional regulators of sugar metabolism; galactitol utilization operon repressor 1885660 13699327 O3K_09000 Escherichia coli O104:H4 str. 2011C-3493 galactitol utilization operon repressor YP_006778503.1 1884887 D 1133852 CDS YP_006778504.1 407481355 13699328 complement(1885742..1886641) 1 NC_018658.1 COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase; lipid kinase 1886641 13699328 O3K_09005 Escherichia coli O104:H4 str. 2011C-3493 lipid kinase YP_006778504.1 1885742 R 1133852 CDS YP_006778505.1 407481356 13699329 1887056..1887373 1 NC_018658.1 hypothetical protein 1887373 13699329 O3K_09010 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778505.1 1887056 D 1133852 CDS YP_006778506.1 407481357 13699330 complement(1887703..1889064) 1 NC_018658.1 COG0826 Collagenase and related proteases; protease 1889064 13699330 O3K_09015 Escherichia coli O104:H4 str. 2011C-3493 protease YP_006778506.1 1887703 R 1133852 CDS YP_006778507.1 407481358 13699331 complement(1889167..1889463) 1 NC_018658.1 COG3668 Plasmid stabilization system protein; plasmid stabilization system protein 1889463 13699331 O3K_09020 Escherichia coli O104:H4 str. 2011C-3493 plasmid stabilization system protein YP_006778507.1 1889167 R 1133852 CDS YP_006778508.1 407481359 13699332 complement(1889465..1889761) 1 NC_018658.1 COG3609 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain; transcriptional regulator 1889761 13699332 O3K_09025 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator YP_006778508.1 1889465 R 1133852 CDS YP_006778509.1 407481360 13699333 complement(1889970..1890302) 1 NC_018658.1 COG3422 Uncharacterized conserved protein; hypothetical protein 1890302 13699333 O3K_09030 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778509.1 1889970 R 1133852 CDS YP_006778510.1 407481361 13699334 complement(1890493..1891215) 1 NC_018658.1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; DNA-binding transcriptional regulator BaeR 1891215 13699334 O3K_09035 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator BaeR YP_006778510.1 1890493 R 1133852 CDS YP_006778511.1 407481362 13699335 complement(1891212..1892615) 1 NC_018658.1 COG0642 Signal transduction histidine kinase; signal transduction histidine-protein kinase BaeS 1892615 13699335 O3K_09040 Escherichia coli O104:H4 str. 2011C-3493 signal transduction histidine-protein kinase BaeS YP_006778511.1 1891212 R 1133852 CDS YP_006778512.1 407481363 13699336 complement(1892612..1894027) 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; transporter 1894027 13699336 O3K_09045 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006778512.1 1892612 R 1133852 CDS YP_006778513.1 407481364 13699337 complement(1894028..1897105) 1 NC_018658.1 COG0841 Cation/multidrug efflux pump; multidrug efflux system subunit MdtC 1897105 13699337 O3K_09050 Escherichia coli O104:H4 str. 2011C-3493 multidrug efflux system subunit MdtC YP_006778513.1 1894028 R 1133852 CDS YP_006778514.1 407481365 13699338 complement(1897106..1900228) 1 NC_018658.1 COG0841 Cation/multidrug efflux pump; multidrug efflux system subunit MdtB 1900228 13699338 O3K_09055 Escherichia coli O104:H4 str. 2011C-3493 multidrug efflux system subunit MdtB YP_006778514.1 1897106 R 1133852 CDS YP_006778515.1 407481366 13699339 complement(1900228..1901475) 1 NC_018658.1 COG0845 Membrane-fusion protein; multidrug efflux system subunit MdtA 1901475 13699339 O3K_09060 Escherichia coli O104:H4 str. 2011C-3493 multidrug efflux system subunit MdtA YP_006778515.1 1900228 R 1133852 CDS YP_006778516.1 407481367 13699340 1902691..1903350 1 NC_018658.1 COG4245 Uncharacterized protein encoded in toxicity protection region of plasmid R478, contains von Willebrand factor (vWF) domain; hypothetical protein 1903350 13699340 O3K_09065 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778516.1 1902691 D 1133852 CDS YP_006778517.1 407481368 13699341 1903347..1904108 1 NC_018658.1 hypothetical protein 1904108 13699341 O3K_09070 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778517.1 1903347 D 1133852 CDS YP_006778518.1 407481369 13699342 1904105..1906045 1 NC_018658.1 COG4248 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains; hypothetical protein 1906045 13699342 O3K_09075 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778518.1 1904105 D 1133852 CDS YP_006778519.1 407481370 13699343 complement(1906057..1907409) 1 NC_018658.1 COG0443 Molecular chaperone; putative chaperone 1907409 13699343 O3K_09080 Escherichia coli O104:H4 str. 2011C-3493 putative chaperone YP_006778519.1 1906057 R 1133852 CDS YP_006778520.1 407481371 13699344 1907543..1908400 1 NC_018658.1 COG0122 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase; 3-methyladenine DNA glycosylase 1908400 13699344 O3K_09085 Escherichia coli O104:H4 str. 2011C-3493 3-methyladenine DNA glycosylase YP_006778520.1 1907543 D 1133852 CDS YP_006778521.1 407481372 13699345 complement(1908439..1911756) 1 NC_018658.1 COG2202 FOG: PAS/PAC domain; putative diguanylate cyclase 1911756 13699345 O3K_09090 Escherichia coli O104:H4 str. 2011C-3493 putative diguanylate cyclase YP_006778521.1 1908439 R 1133852 CDS YP_006778522.1 407481373 13699346 1912074..1912715 1 NC_018658.1 COG0572 Uridine kinase; uridine/cytidine kinase 1912715 13699346 O3K_09095 Escherichia coli O104:H4 str. 2011C-3493 uridine/cytidine kinase YP_006778522.1 1912074 D 1133852 CDS YP_006778523.1 407481374 13699347 1912807..1913388 1 NC_018658.1 COG0717 Deoxycytidine deaminase; deoxycytidine triphosphate deaminase 1913388 dcd 13699347 dcd Escherichia coli O104:H4 str. 2011C-3493 deoxycytidine triphosphate deaminase YP_006778523.1 1912807 D 1133852 CDS YP_006778524.1 407481375 13699348 1913410..1915263 1 NC_018658.1 COG2982 Uncharacterized protein involved in outer membrane biogenesis; putative assembly protein 1915263 13699348 O3K_09105 Escherichia coli O104:H4 str. 2011C-3493 putative assembly protein YP_006778524.1 1913410 D 1133852 CDS YP_006778525.1 407481376 13699349 complement(1915537..1917120) 1 NC_018658.1 COG0861 Membrane protein TerC, possibly involved in tellurium resistance; hypothetical protein 1917120 13699349 O3K_09110 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778525.1 1915537 R 1133852 CDS YP_006778526.1 407481377 13699350 1917779..1918918 1 NC_018658.1 COG1596 Periplasmic protein involved in polysaccharide export; polysaccharide export protein Wza 1918918 13699350 O3K_09115 Escherichia coli O104:H4 str. 2011C-3493 polysaccharide export protein Wza YP_006778526.1 1917779 D 1133852 CDS YP_006778527.1 407481378 13699351 1918924..1919367 1 NC_018658.1 COG0394 Protein-tyrosine-phosphatase; tyrosine phosphatase 1919367 13699351 O3K_09120 Escherichia coli O104:H4 str. 2011C-3493 tyrosine phosphatase YP_006778527.1 1918924 D 1133852 CDS YP_006778528.1 407481379 13699352 1919370..1921532 1 NC_018658.1 COG3206 Uncharacterized protein involved in exopolysaccharide biosynthesis; tyrosine kinase 1921532 13699352 O3K_09125 Escherichia coli O104:H4 str. 2011C-3493 tyrosine kinase YP_006778528.1 1919370 D 1133852 CDS YP_006778529.1 407481380 13699353 1921710..1922549 1 NC_018658.1 COG0463 Glycosyltransferases involved in cell wall biogenesis; putative glycosyl transferase 1922549 13699353 O3K_09130 Escherichia coli O104:H4 str. 2011C-3493 putative glycosyl transferase YP_006778529.1 1921710 D 1133852 CDS YP_006778530.1 407481381 13699354 1922552..1923040 1 NC_018658.1 COG1045 Serine acetyltransferase; putative acyl transferase 1923040 13699354 O3K_09135 Escherichia coli O104:H4 str. 2011C-3493 putative acyl transferase YP_006778530.1 1922552 D 1133852 CDS YP_006778531.1 407481382 13699355 1923037..1924254 1 NC_018658.1 COG0438 Glycosyltransferase; putative glycosyl transferase 1924254 13699355 O3K_09140 Escherichia coli O104:H4 str. 2011C-3493 putative glycosyl transferase YP_006778531.1 1923037 D 1133852 CDS YP_006778532.1 407481383 13699356 1924229..1925446 1 NC_018658.1 putative colanic acid biosynthesis protein 1925446 wcaD 13699356 wcaD Escherichia coli O104:H4 str. 2011C-3493 putative colanic acid biosynthesis protein YP_006778532.1 1924229 D 1133852 CDS YP_006778533.1 407481384 13699357 1925457..1926203 1 NC_018658.1 COG0463 Glycosyltransferases involved in cell wall biogenesis; putative glycosyl transferase 1926203 13699357 O3K_09150 Escherichia coli O104:H4 str. 2011C-3493 putative glycosyl transferase YP_006778533.1 1925457 D 1133852 CDS YP_006778534.1 407481385 13699358 1926219..1926767 1 NC_018658.1 COG0110 Acetyltransferase (isoleucine patch superfamily); putative acyl transferase 1926767 13699358 O3K_09155 Escherichia coli O104:H4 str. 2011C-3493 putative acyl transferase YP_006778534.1 1926219 D 1133852 CDS YP_006778535.1 407481386 13699359 1926794..1927915 1 NC_018658.1 COG1089 GDP-D-mannose dehydratase; GDP-mannose 4,6-dehydratase 1927915 13699359 O3K_09160 Escherichia coli O104:H4 str. 2011C-3493 GDP-mannose 4,6-dehydratase YP_006778535.1 1926794 D 1133852 CDS YP_006778536.1 407481387 13699360 1927918..1928883 1 NC_018658.1 COG0451 Nucleoside-diphosphate-sugar epimerases; bifunctional GDP-4-dehydro-6-deoxy-D-mannose epimerase/GDP-4-dehydro-6-L-deoxygalactose reductase 1928883 13699360 O3K_09165 Escherichia coli O104:H4 str. 2011C-3493 bifunctional GDP-4-dehydro-6-deoxy-D-mannose epimerase/GDP-4-dehydro-6-L-deoxygalactose reductase YP_006778536.1 1927918 D 1133852 CDS YP_006778537.1 407481388 13699361 1928886..1929365 1 NC_018658.1 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; GDP-mannose mannosyl hydrolase 1929365 13699361 O3K_09170 Escherichia coli O104:H4 str. 2011C-3493 GDP-mannose mannosyl hydrolase YP_006778537.1 1928886 D 1133852 CDS YP_006778538.1 407481389 13699362 1929362..1930585 1 NC_018658.1 COG0438 Glycosyltransferase; putative glycosyl transferase 1930585 13699362 O3K_09175 Escherichia coli O104:H4 str. 2011C-3493 putative glycosyl transferase YP_006778538.1 1929362 D 1133852 CDS YP_006778539.1 407481390 13699363 1930588..1932024 1 NC_018658.1 COG0836 Mannose-1-phosphate guanylyltransferase; mannose-1-phosphate guanyltransferase 1932024 cpsB 13699363 cpsB Escherichia coli O104:H4 str. 2011C-3493 mannose-1-phosphate guanyltransferase YP_006778539.1 1930588 D 1133852 CDS YP_006778540.1 407481391 13699364 1932393..1933763 1 NC_018658.1 COG1109 Phosphomannomutase; phosphomannomutase 1933763 13699364 O3K_09185 Escherichia coli O104:H4 str. 2011C-3493 phosphomannomutase YP_006778540.1 1932393 D 1133852 CDS YP_006778541.1 407481392 13699365 1933818..1935212 1 NC_018658.1 COG2148 Sugar transferases involved in lipopolysaccharide synthesis; putative UDP-glucose lipid carrier transferase 1935212 13699365 O3K_09190 Escherichia coli O104:H4 str. 2011C-3493 putative UDP-glucose lipid carrier transferase YP_006778541.1 1933818 D 1133852 CDS YP_006778542.1 407481393 13699366 1935214..1936692 1 NC_018658.1 COG2244 Membrane protein involved in the export of O-antigen and teichoic acid; colanic acid exporter 1936692 13699366 O3K_09195 Escherichia coli O104:H4 str. 2011C-3493 colanic acid exporter YP_006778542.1 1935214 D 1133852 CDS YP_006778543.1 407481394 13699367 1936977..1938257 1 NC_018658.1 COG2327 Uncharacterized conserved protein; colanic acid biosynthesis protein 1938257 13699367 O3K_09200 Escherichia coli O104:H4 str. 2011C-3493 colanic acid biosynthesis protein YP_006778543.1 1936977 D 1133852 CDS YP_006778544.1 407481395 13699368 1938254..1939474 1 NC_018658.1 COG0438 Glycosyltransferase; colanic acid biosynthesis glycosyltransferase WcaL 1939474 13699368 O3K_09205 Escherichia coli O104:H4 str. 2011C-3493 colanic acid biosynthesis glycosyltransferase WcaL YP_006778544.1 1938254 D 1133852 CDS YP_006778545.1 407481396 13699369 1939485..1940879 1 NC_018658.1 putative colanic acid biosynthesis protein 1940879 wcaM 13699369 wcaM Escherichia coli O104:H4 str. 2011C-3493 putative colanic acid biosynthesis protein YP_006778545.1 1939485 D 1133852 CDS YP_006778546.1 407481397 13699370 1941037..1942032 1 NC_018658.1 COG0451 Nucleoside-diphosphate-sugar epimerases; UDP-N-acetylglucosamine 4-epimerase 1942032 13699370 O3K_09215 Escherichia coli O104:H4 str. 2011C-3493 UDP-N-acetylglucosamine 4-epimerase YP_006778546.1 1941037 D 1133852 CDS YP_006778547.1 407481398 13699371 1942275..1943168 1 NC_018658.1 COG1210 UDP-glucose pyrophosphorylase; GalU regulator GalF 1943168 13699371 O3K_09220 Escherichia coli O104:H4 str. 2011C-3493 GalU regulator GalF YP_006778547.1 1942275 D 1133852 CDS YP_006778548.1 407481399 13699372 1943529..1944149 1 NC_018658.1 COG0110 Acetyltransferase (isoleucine patch superfamily); WckD 1944149 13699372 O3K_09225 Escherichia coli O104:H4 str. 2011C-3493 WckD YP_006778548.1 1943529 D 1133852 CDS YP_006778549.1 407481400 13699373 1944154..1945194 1 NC_018658.1 COG2089 Sialic acid synthase; NnaB 1945194 13699373 O3K_09230 Escherichia coli O104:H4 str. 2011C-3493 NnaB YP_006778549.1 1944154 D 1133852 CDS YP_006778550.1 407481401 13699374 1945200..1946465 1 NC_018658.1 COG1083 CMP-N-acetylneuraminic acid synthetase; N-acylneuraminate cytidylyltransferase 1946465 13699374 O3K_09235 Escherichia coli O104:H4 str. 2011C-3493 N-acylneuraminate cytidylyltransferase YP_006778550.1 1945200 D 1133852 CDS YP_006778551.1 407481402 13699375 1946462..1947625 1 NC_018658.1 COG0381 UDP-N-acetylglucosamine 2-epimerase; NnaA 1947625 13699375 O3K_09240 Escherichia coli O104:H4 str. 2011C-3493 NnaA YP_006778551.1 1946462 D 1133852 CDS YP_006778552.1 407481403 13699376 1947710..1948660 1 NC_018658.1 hypothetical protein 1948660 13699376 O3K_09245 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778552.1 1947710 D 1133852 CDS YP_006778553.1 407481404 13699377 1948657..1949769 1 NC_018658.1 hypothetical protein 1949769 13699377 O3K_09250 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778553.1 1948657 D 1133852 CDS YP_006778554.1 407481405 13699378 1949775..1950998 1 NC_018658.1 COG0438 Glycosyltransferase; WbwB 1950998 13699378 O3K_09255 Escherichia coli O104:H4 str. 2011C-3493 WbwB YP_006778554.1 1949775 D 1133852 CDS YP_006778555.1 407481406 13699379 1950998..1952275 1 NC_018658.1 COG2244 Membrane protein involved in the export of O-antigen and teichoic acid; Wzx 1952275 13699379 O3K_09260 Escherichia coli O104:H4 str. 2011C-3493 Wzx YP_006778555.1 1950998 D 1133852 CDS YP_006778556.1 407481407 13699380 1952300..1953106 1 NC_018658.1 COG0463 Glycosyltransferases involved in cell wall biogenesis; glycosyl transferase 1953106 13699380 O3K_09265 Escherichia coli O104:H4 str. 2011C-3493 glycosyl transferase YP_006778556.1 1952300 D 1133852 CDS YP_006778557.1 407481408 13699381 1953227..1954633 1 NC_018658.1 COG0362 6-phosphogluconate dehydrogenase; 6-phosphogluconate dehydrogenase 1954633 13699381 O3K_09270 Escherichia coli O104:H4 str. 2011C-3493 6-phosphogluconate dehydrogenase YP_006778557.1 1953227 D 1133852 CDS YP_006778558.1 407481409 13699382 1954881..1956047 1 NC_018658.1 COG1004 Predicted UDP-glucose 6-dehydrogenase; UDP-glucose 6-dehydrogenase 1956047 13699382 O3K_09275 Escherichia coli O104:H4 str. 2011C-3493 UDP-glucose 6-dehydrogenase YP_006778558.1 1954881 D 1133852 CDS YP_006778559.1 407481410 13699383 1956194..1957171 1 NC_018658.1 COG3765 Chain length determinant protein; chain length determinant protein WzzB 1957171 13699383 O3K_09280 Escherichia coli O104:H4 str. 2011C-3493 chain length determinant protein WzzB YP_006778559.1 1956194 D 1133852 CDS YP_006778560.1 407481411 13699384 complement(1957269..1957880) 1 NC_018658.1 COG0139 Phosphoribosyl-AMP cyclohydrolase; bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase 1957880 13699384 O3K_09285 Escherichia coli O104:H4 str. 2011C-3493 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase YP_006778560.1 1957269 R 1133852 CDS YP_006778561.1 407481412 13699385 complement(1957874..1958650) 1 NC_018658.1 COG0107 Imidazoleglycerol-phosphate synthase; imidazole glycerol phosphate synthase subunit HisF 1958650 13699385 O3K_09290 Escherichia coli O104:H4 str. 2011C-3493 imidazole glycerol phosphate synthase subunit HisF YP_006778561.1 1957874 R 1133852 CDS YP_006778562.1 407481413 13699386 complement(1958632..1959369) 1 NC_018658.1 COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 1959369 13699386 O3K_09295 Escherichia coli O104:H4 str. 2011C-3493 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase YP_006778562.1 1958632 R 1133852 CDS YP_006778563.1 407481414 13699387 complement(1959369..1959959) 1 NC_018658.1 COG0118 Glutamine amidotransferase; imidazole glycerol phosphate synthase subunit HisH 1959959 hisH 13699387 hisH Escherichia coli O104:H4 str. 2011C-3493 imidazole glycerol phosphate synthase subunit HisH YP_006778563.1 1959369 R 1133852 CDS YP_006778564.1 407481415 13699388 complement(1959959..1961026) 1 NC_018658.1 COG0241 Histidinol phosphatase and related phosphatases; imidazole glycerol-phosphate dehydratase/histidinol phosphatase 1961026 13699388 O3K_09305 Escherichia coli O104:H4 str. 2011C-3493 imidazole glycerol-phosphate dehydratase/histidinol phosphatase YP_006778564.1 1959959 R 1133852 CDS YP_006778565.1 407481416 13699389 complement(1961026..1962096) 1 NC_018658.1 COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; histidinol-phosphate aminotransferase 1962096 13699389 O3K_09310 Escherichia coli O104:H4 str. 2011C-3493 histidinol-phosphate aminotransferase YP_006778565.1 1961026 R 1133852 CDS YP_006778566.1 407481417 13699390 complement(1962093..1963397) 1 NC_018658.1 COG0141 Histidinol dehydrogenase; bifunctional histidinal dehydrogenase/ histidinol dehydrogenase 1963397 hisD 13699390 hisD Escherichia coli O104:H4 str. 2011C-3493 bifunctional histidinal dehydrogenase/ histidinol dehydrogenase YP_006778566.1 1962093 R 1133852 CDS YP_006778567.1 407481418 13699391 complement(1963403..1964302) 1 NC_018658.1 COG0040 ATP phosphoribosyltransferase; ATP phosphoribosyltransferase 1964302 hisG 13699391 hisG Escherichia coli O104:H4 str. 2011C-3493 ATP phosphoribosyltransferase YP_006778567.1 1963403 R 1133852 CDS YP_006778568.1 407481419 13699392 1964782..1965033 1 NC_018658.1 COG2161 Antitoxin of toxin-antitoxin stability system; antitoxin YefM 1965033 13699392 O3K_09325 Escherichia coli O104:H4 str. 2011C-3493 antitoxin YefM YP_006778568.1 1964782 D 1133852 CDS YP_006778569.1 407481420 13699393 1965030..1965284 1 NC_018658.1 COG4115 Uncharacterized protein conserved in bacteria; Toxin yoeB 1965284 13699393 O3K_09330 Escherichia coli O104:H4 str. 2011C-3493 Toxin yoeB YP_006778569.1 1965030 D 1133852 CDS YP_006778570.1 407481421 13699394 1965367..1966191 1 NC_018658.1 COG0451 Nucleoside-diphosphate-sugar epimerases; epimerase, with NAD(P)-binding Rossmann-fold domain 1966191 13699394 O3K_09335 Escherichia coli O104:H4 str. 2011C-3493 epimerase, with NAD(P)-binding Rossmann-fold domain YP_006778570.1 1965367 D 1133852 CDS YP_006778571.1 407481422 13699395 1966237..1967166 1 NC_018658.1 COG0583 Transcriptional regulator; putative DNA-binding transcriptional regulator 1967166 13699395 O3K_09340 Escherichia coli O104:H4 str. 2011C-3493 putative DNA-binding transcriptional regulator YP_006778571.1 1966237 D 1133852 CDS YP_006778572.1 407481423 13699396 1967433..1968791 1 NC_018658.1 COG0531 Amino acid transporters; amino acid permease 1968791 13699396 O3K_09345 Escherichia coli O104:H4 str. 2011C-3493 amino acid permease YP_006778572.1 1967433 D 1133852 CDS YP_006778573.1 407481424 13699397 1968970..1970028 1 NC_018658.1 COG2391 Predicted transporter component; hypothetical protein 1970028 13699397 O3K_09350 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778573.1 1968970 D 1133852 CDS YP_006778574.1 407481425 13699398 1970042..1970269 1 NC_018658.1 COG0425 Predicted redox protein, regulator of disulfide bond formation; hypothetical protein 1970269 13699398 O3K_09355 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778574.1 1970042 D 1133852 CDS YP_006778575.1 407481426 13699399 complement(1970312..1971736) 1 NC_018658.1 COG2925 Exonuclease I; exonuclease I 1971736 sbcB 13699399 sbcB Escherichia coli O104:H4 str. 2011C-3493 exonuclease I YP_006778575.1 1970312 R 1133852 CDS YP_006778576.1 407481427 13699400 1971948..1973114 1 NC_018658.1 COG1686 D-alanyl-D-alanine carboxypeptidase; D-alanyl-D-alanine carboxypeptidase 1973114 dacD 13699400 dacD Escherichia coli O104:H4 str. 2011C-3493 D-alanyl-D-alanine carboxypeptidase YP_006778576.1 1971948 D 1133852 CDS YP_006778577.1 407481428 13699401 1973233..1973706 1 NC_018658.1 COG3449 DNA gyrase inhibitor; DNA gyrase inhibitor 1973706 13699401 O3K_09370 Escherichia coli O104:H4 str. 2011C-3493 DNA gyrase inhibitor YP_006778577.1 1973233 D 1133852 CDS YP_006778578.1 407481429 13699402 1973904..1974584 1 NC_018658.1 COG1289 Predicted membrane protein; inner membrane protein YeeA 1974584 13699402 O3K_09375 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YeeA YP_006778578.1 1973904 D 1133852 CDS YP_006778579.1 407481430 13699403 1974648..1975628 1 NC_018658.1 COG3547 Transposase and inactivated derivatives; IS621 transposase 1975628 13699403 O3K_09380 Escherichia coli O104:H4 str. 2011C-3493 IS621 transposase YP_006778579.1 1974648 D 1133852 CDS YP_006778580.1 407481431 13699404 1975819..1976241 1 NC_018658.1 inner membrane protein YeeA 1976241 13699404 O3K_09385 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YeeA YP_006778580.1 1975819 D 1133852 CDS YP_006778581.1 407481432 13699405 1976413..1976742 1 NC_018658.1 COG2926 Uncharacterized protein conserved in bacteria; hypothetical protein 1976742 13699405 O3K_09390 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778581.1 1976413 D 1133852 CDS YP_006778582.1 407481433 13699406 complement(1976843..1977067) 1 NC_018658.1 COG4917 Ethanolamine utilization protein; hypothetical protein 1977067 13699406 O3K_09395 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778582.1 1976843 R 1133852 CDS YP_006778583.1 407481434 13699407 complement(1977514..1977627) 1 NC_018658.1 hypothetical protein 1977627 13699407 O3K_09400 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778583.1 1977514 R 1133852 CDS YP_006778584.1 407481435 13699408 complement(1977640..1977834) 1 NC_018658.1 hypothetical protein 1977834 13699408 O3K_09405 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778584.1 1977640 R 1133852 CDS YP_006778585.1 407481436 13699409 complement(1977941..1978204) 1 NC_018658.1 hypothetical protein 1978204 13699409 O3K_09410 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778585.1 1977941 R 1133852 CDS YP_006778586.1 407481437 13699410 complement(1978293..1978661) 1 NC_018658.1 hypothetical protein 1978661 13699410 O3K_09415 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778586.1 1978293 R 1133852 CDS YP_006778587.1 407481438 13699411 complement(1978735..1978956) 1 NC_018658.1 hypothetical protein 1978956 13699411 O3K_09420 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778587.1 1978735 R 1133852 CDS YP_006778588.1 407481439 13699412 complement(1979019..1979495) 1 NC_018658.1 COG2003 DNA repair proteins; putative DNA repair protein 1979495 13699412 O3K_09425 Escherichia coli O104:H4 str. 2011C-3493 putative DNA repair protein YP_006778588.1 1979019 R 1133852 CDS YP_006778589.1 407481440 13699413 complement(1979511..1979990) 1 NC_018658.1 antirestriction protein 1979990 13699413 O3K_09430 Escherichia coli O104:H4 str. 2011C-3493 antirestriction protein YP_006778589.1 1979511 R 1133852 CDS YP_006778590.1 407481441 13699414 complement(1980072..1980893) 1 NC_018658.1 hypothetical protein 1980893 13699414 O3K_09435 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778590.1 1980072 R 1133852 CDS YP_006778591.1 407481442 13699415 complement(1981114..1981524) 1 NC_018658.1 hypothetical protein 1981524 13699415 O3K_09440 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778591.1 1981114 R 1133852 CDS YP_006778592.1 407481443 13699416 complement(1981540..1982223) 1 NC_018658.1 hypothetical protein 1982223 13699416 O3K_09445 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778592.1 1981540 R 1133852 CDS YP_006778593.1 407481444 13699417 complement(1982359..1983429) 1 NC_018658.1 COG1752 Predicted esterase of the alpha-beta hydrolase superfamily; hypothetical protein 1983429 13699417 O3K_09450 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778593.1 1982359 R 1133852 CDS YP_006778594.1 407481445 13699418 complement(1983426..1984331) 1 NC_018658.1 hypothetical protein 1984331 13699418 O3K_09455 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778594.1 1983426 R 1133852 CDS YP_006778595.1 407481446 13699419 complement(1984328..1986724) 1 NC_018658.1 COG0699 Predicted GTPases (dynamin-related); hypothetical protein 1986724 13699419 O3K_09460 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778595.1 1984328 R 1133852 CDS YP_006778596.1 407481447 13699420 complement(1987897..1989048) 1 NC_018658.1 hypothetical protein 1989048 13699420 O3K_09475 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778596.1 1987897 R 1133852 CDS YP_006778597.1 407481448 13699421 complement(1990252..1990527) 1 NC_018658.1 COG4584 Transposase and inactivated derivatives; transposase subunit 1990527 13699421 O3K_09480 Escherichia coli O104:H4 str. 2011C-3493 transposase subunit YP_006778597.1 1990252 R 1133852 CDS YP_006778598.1 407481449 13699422 complement(1990433..1990729) 1 NC_018658.1 hypothetical protein 1990729 13699422 O3K_09485 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778598.1 1990433 R 1133852 CDS YP_006778599.1 407481450 13699423 1990616..1990999 1 NC_018658.1 COG2963 Transposase and inactivated derivatives; hypothetical protein 1990999 13699423 O3K_09490 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778599.1 1990616 D 1133852 CDS YP_006778600.1 407481451 13699424 1990996..1991343 1 NC_018658.1 COG3436 Transposase and inactivated derivatives; IS66 family protein; transposase ORF 2, IS66 family protein 1991343 13699424 O3K_09495 Escherichia coli O104:H4 str. 2011C-3493 transposase ORF 2, IS66 family protein YP_006778600.1 1990996 D 1133852 CDS YP_006778601.1 407481452 13699425 1991393..1992928 1 NC_018658.1 COG3436 Transposase and inactivated derivatives; IS66 family protein; transposase ORF 1, IS66 family protein 1992928 13699425 O3K_09500 Escherichia coli O104:H4 str. 2011C-3493 transposase ORF 1, IS66 family protein YP_006778601.1 1991393 D 1133852 CDS YP_006778602.1 407481453 13699426 complement(1993887..1994495) 1 NC_018658.1 hypothetical protein 1994495 13699426 O3K_09505 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778602.1 1993887 R 1133852 CDS YP_006778603.1 407481454 13699427 complement(1994583..1994789) 1 NC_018658.1 COG3311 Predicted transcriptional regulator; InterPro motifs Prophage CP4-57 regulatory protein (AlpA) 1994789 13699427 O3K_09510 Escherichia coli O104:H4 str. 2011C-3493 InterPro motifs Prophage CP4-57 regulatory protein (AlpA) YP_006778603.1 1994583 R 1133852 CDS YP_006778604.1 407481455 13699428 1994896..1995198 1 NC_018658.1 hypothetical protein 1995198 13699428 O3K_09515 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778604.1 1994896 D 1133852 CDS YP_006778605.1 407481456 13699429 complement(1995916..1996116) 1 NC_018658.1 hypothetical protein 1996116 13699429 O3K_09520 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778605.1 1995916 R 1133852 CDS YP_006778606.1 407481457 13699430 1996316..1996885 1 NC_018658.1 hypothetical protein 1996885 13699430 O3K_09525 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778606.1 1996316 D 1133852 CDS YP_006778607.1 407481458 13699431 1997139..1997546 1 NC_018658.1 COG0085 DNA-directed RNA polymerase, beta subunit/140 kD subunit; hypothetical protein 1997546 13699431 O3K_09530 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778607.1 1997139 D 1133852 CDS YP_006778608.1 407481459 13699432 1997534..1997944 1 NC_018658.1 hypothetical protein 1997944 13699432 O3K_09535 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778608.1 1997534 D 1133852 CDS YP_006778609.1 407481460 13699433 complement(1998367..1998618) 1 NC_018658.1 hypothetical protein 1998618 13699433 O3K_09540 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778609.1 1998367 R 1133852 CDS YP_006778610.1 407481461 13699434 1998750..1999607 1 NC_018658.1 COG3464 Transposase and inactivated derivatives; transposase, ISL3 family protein 1999607 13699434 O3K_09545 Escherichia coli O104:H4 str. 2011C-3493 transposase, ISL3 family protein YP_006778610.1 1998750 D 1133852 CDS YP_006778611.1 407481462 13699435 1999686..1999847 1 NC_018658.1 COG3464 Transposase and inactivated derivatives; transposase (part) 1999847 13699435 O3K_09550 Escherichia coli O104:H4 str. 2011C-3493 transposase (part) YP_006778611.1 1999686 D 1133852 CDS YP_006778612.1 407481463 13699436 1999948..2000115 1 NC_018658.1 COG0405 Gamma-glutamyltransferase; hypothetical protein 2000115 13699436 O3K_09555 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778612.1 1999948 D 1133852 CDS YP_006778613.1 407481464 13699437 2000106..2000219 1 NC_018658.1 hypothetical protein 2000219 13699437 O3K_09560 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778613.1 2000106 D 1133852 CDS YP_006778614.1 407481465 13699438 complement(2000259..2001293) 1 NC_018658.1 COG1735 Predicted metal-dependent hydrolase with the TIM-barrel fold; phosphotriesterase-related protein 2001293 13699438 O3K_09565 Escherichia coli O104:H4 str. 2011C-3493 phosphotriesterase-related protein YP_006778614.1 2000259 R 1133852 CDS YP_006778615.1 407481466 13699439 complement(2002318..2003076) 1 NC_018658.1 COG5426 Uncharacterized membrane protein; hypothetical protein 2003076 13699439 O3K_09580 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778615.1 2002318 R 1133852 CDS YP_006778616.1 407481467 13699440 complement(2003090..2004304) 1 NC_018658.1 COG1349 Transcriptional regulators of sugar metabolism; carbohydrate kinase 2004304 13699440 O3K_09585 Escherichia coli O104:H4 str. 2011C-3493 carbohydrate kinase YP_006778616.1 2003090 R 1133852 CDS YP_006778617.1 407481468 13699441 complement(2004500..2004616) 1 NC_018658.1 COG3436 Transposase and inactivated derivatives; hypothetical protein 2004616 13699441 O3K_09590 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778617.1 2004500 R 1133852 CDS YP_006778618.1 407481469 13699442 complement(2004556..2005047) 1 NC_018658.1 hypothetical protein 2005047 13699442 O3K_09595 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778618.1 2004556 R 1133852 CDS YP_006778619.1 407481470 13699443 2005738..2005902 1 NC_018658.1 hypothetical protein 2005902 13699443 O3K_09600 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778619.1 2005738 D 1133852 CDS YP_006778620.1 407481471 13699444 2006367..2006912 1 NC_018658.1 COG2087 Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase; adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase 2006912 cobU 13699444 cobU Escherichia coli O104:H4 str. 2011C-3493 adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase YP_006778620.1 2006367 D 1133852 CDS YP_006778621.1 407481472 13699445 2006909..2007652 1 NC_018658.1 COG0368 Cobalamin-5-phosphate synthase; cobalamin synthase 2007652 cobS 13699445 cobS Escherichia coli O104:H4 str. 2011C-3493 cobalamin synthase YP_006778621.1 2006909 D 1133852 CDS YP_006778622.1 407481473 13699446 2007664..2008743 1 NC_018658.1 COG2038 NaMN:DMB phosphoribosyltransferase; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 2008743 cobT 13699446 cobT Escherichia coli O104:H4 str. 2011C-3493 nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase YP_006778622.1 2007664 D 1133852 CDS YP_006778623.1 407481474 13699447 2008808..2009740 1 NC_018658.1 COG1376 Uncharacterized protein conserved in bacteria; L,D-transpeptidase 2009740 13699447 O3K_09620 Escherichia coli O104:H4 str. 2011C-3493 L,D-transpeptidase YP_006778623.1 2008808 D 1133852 CDS YP_006778624.1 407481475 13699449 2010198..2011115 1 NC_018658.1 COG0583 Transcriptional regulator; nitrogen assimilation transcriptional regulator 2011115 13699449 O3K_09625 Escherichia coli O104:H4 str. 2011C-3493 nitrogen assimilation transcriptional regulator YP_006778624.1 2010198 D 1133852 CDS YP_006778625.1 407481476 13699450 2011217..2012167 1 NC_018658.1 COG0583 Transcriptional regulator; transcriptional regulator Cbl 2012167 cbl 13699450 cbl Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator Cbl YP_006778625.1 2011217 D 1133852 CDS YP_006778626.1 407481477 13699452 2012288..2013928 1 NC_018658.1 COG0534 Na+-driven multidrug efflux pump; MATE family multidrug exporter 2013928 13699452 O3K_09635 Escherichia coli O104:H4 str. 2011C-3493 MATE family multidrug exporter YP_006778626.1 2012288 D 1133852 CDS YP_006778627.1 407481478 13699454 complement(2014556..2015272) 1 NC_018658.1 COG0217 Uncharacterized conserved protein; hypothetical protein 2015272 13699454 O3K_09640 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778627.1 2014556 R 1133852 CDS YP_006778628.1 407481479 13699455 complement(2015615..2017069) 1 NC_018658.1 COG0775 Nucleoside phosphorylase; AMP nucleosidase 2017069 13699455 O3K_09645 Escherichia coli O104:H4 str. 2011C-3493 AMP nucleosidase YP_006778628.1 2015615 R 1133852 CDS YP_006778629.1 407481480 13699456 complement(2017171..2018487) 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; shikimate transporter 2018487 13699456 O3K_09650 Escherichia coli O104:H4 str. 2011C-3493 shikimate transporter YP_006778629.1 2017171 R 1133852 CDS YP_006778630.1 407481481 13699457 2018802..2019854 1 NC_018658.1 COG0859 ADP-heptose:LPS heptosyltransferase; hypothetical protein 2019854 13699457 O3K_09655 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778630.1 2018802 D 1133852 CDS YP_006778631.1 407481482 13699458 complement(2021976..2022116) 1 NC_018658.1 hypothetical protein 2022116 13699458 O3K_09670 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778631.1 2021976 R 1133852 CDS YP_006778632.1 407481483 13699459 complement(2022073..2022495) 1 NC_018658.1 hypothetical protein 2022495 13699459 O3K_09675 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778632.1 2022073 R 1133852 CDS YP_006778633.1 407481484 13699460 complement(2023473..2025494) 1 NC_018658.1 COG1629 Outer membrane receptor proteins, mostly Fe transport; Yersiniabactin/pesticin outer membrane receptor (IRPC) 2025494 13699460 O3K_09680 Escherichia coli O104:H4 str. 2011C-3493 Yersiniabactin/pesticin outer membrane receptor (IRPC) YP_006778633.1 2023473 R 1133852 CDS YP_006778634.1 407481485 13699461 complement(2025625..2027202) 1 NC_018658.1 COG1021 Peptide arylation enzymes; salicyl-AMP ligase YbtE 2027202 13699461 O3K_09685 Escherichia coli O104:H4 str. 2011C-3493 salicyl-AMP ligase YbtE YP_006778634.1 2025625 R 1133852 CDS YP_006778635.1 407481486 13699462 complement(2027206..2028009) 1 NC_018658.1 COG3208 Predicted thioesterase involved in non-ribosomal peptide biosynthesis; siderophore biosynthetic protein 2028009 13699462 O3K_09690 Escherichia coli O104:H4 str. 2011C-3493 siderophore biosynthetic protein YP_006778635.1 2027206 R 1133852 CDS YP_006778636.1 407481487 13699463 complement(2028006..2029106) 1 NC_018658.1 COG4693 Oxidoreductase (NAD-binding), involved in siderophore biosynthesis; Thiazolinyl-S-HMWP1 reductase YbtU 2029106 13699463 O3K_09695 Escherichia coli O104:H4 str. 2011C-3493 Thiazolinyl-S-HMWP1 reductase YbtU YP_006778636.1 2028006 R 1133852 CDS YP_006778637.1 407481488 13699464 complement(2029103..2038594) 1 NC_018658.1 COG3321 Polyketide synthase modules and related proteins; High-molecular-weight nonribosomal peptide/polyketide synthetase 1 (HMWP1) 2038594 13699464 O3K_09700 Escherichia coli O104:H4 str. 2011C-3493 High-molecular-weight nonribosomal peptide/polyketide synthetase 1 (HMWP1) YP_006778637.1 2029103 R 1133852 CDS YP_006778638.1 407481489 13699465 complement(2038682..2044789) 1 NC_018658.1 COG1020 Non-ribosomal peptide synthetase modules and related proteins; High-molecular-weight nonribosomal peptide/polyketide synthetase 2 (HMWP2) 2044789 13699465 O3K_09705 Escherichia coli O104:H4 str. 2011C-3493 High-molecular-weight nonribosomal peptide/polyketide synthetase 2 (HMWP2) YP_006778638.1 2038682 R 1133852 CDS YP_006778639.1 407481490 13699466 complement(2044980..2045939) 1 NC_018658.1 COG2207 AraC-type DNA-binding domain-containing proteins; AraC family transcriptional regulator 2045939 13699466 O3K_09710 Escherichia coli O104:H4 str. 2011C-3493 AraC family transcriptional regulator YP_006778639.1 2044980 R 1133852 CDS YP_006778640.1 407481491 13699467 2046106..2047908 1 NC_018658.1 COG1132 ABC-type multidrug transport system, ATPase and permease components; yersiniabactin-iron ABC transporter permease/ATP-binding protein YbtP 2047908 13699467 O3K_09715 Escherichia coli O104:H4 str. 2011C-3493 yersiniabactin-iron ABC transporter permease/ATP-binding protein YbtP YP_006778640.1 2046106 D 1133852 CDS YP_006778641.1 407481492 13699468 2047895..2049697 1 NC_018658.1 COG1132 ABC-type multidrug transport system, ATPase and permease components; yersiniabactin-iron ABC transporter permease/ATP-binding protein YbtQ 2049697 13699468 O3K_09720 Escherichia coli O104:H4 str. 2011C-3493 yersiniabactin-iron ABC transporter permease/ATP-binding protein YbtQ YP_006778641.1 2047895 D 1133852 CDS YP_006778642.1 407481493 13699469 2049690..2050970 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; yersiniabactin-iron transporter permease YbtX 2050970 13699469 O3K_09725 Escherichia coli O104:H4 str. 2011C-3493 yersiniabactin-iron transporter permease YbtX YP_006778642.1 2049690 D 1133852 CDS YP_006778643.1 407481494 13699470 2050998..2052302 1 NC_018658.1 COG0147 Anthranilate/para-aminobenzoate synthases component I; salicylate synthase Irp9 2052302 13699470 O3K_09730 Escherichia coli O104:H4 str. 2011C-3493 salicylate synthase Irp9 YP_006778643.1 2050998 D 1133852 CDS YP_006778644.1 407481495 13699471 complement(2052496..2053758) 1 NC_018658.1 COG0582 Integrase; integrase 2053758 13699471 O3K_09735 Escherichia coli O104:H4 str. 2011C-3493 integrase YP_006778644.1 2052496 R 1133852 CDS YP_006778645.1 407481496 13699473 complement(2054096..2054893) 1 NC_018658.1 COG3228 Uncharacterized protein conserved in bacteria; DgsA anti-repressor MtfA 2054893 13699473 O3K_09740 Escherichia coli O104:H4 str. 2011C-3493 DgsA anti-repressor MtfA YP_006778645.1 2054096 R 1133852 CDS YP_006778646.1 407481497 13699475 complement(2055746..2056396) 1 NC_018658.1 COG3443 Predicted periplasmic or secreted protein; zinc/cadmium-binding protein 2056396 13699475 O3K_09745 Escherichia coli O104:H4 str. 2011C-3493 zinc/cadmium-binding protein YP_006778646.1 2055746 R 1133852 CDS YP_006778647.1 407481498 13699476 complement(2056653..2057288) 1 NC_018658.1 COG2717 Predicted membrane protein; putative sulfite oxidase subunit YedZ 2057288 13699476 O3K_09750 Escherichia coli O104:H4 str. 2011C-3493 putative sulfite oxidase subunit YedZ YP_006778647.1 2056653 R 1133852 CDS YP_006778648.1 407481499 13699477 complement(2057289..2058293) 1 NC_018658.1 COG2041 Sulfite oxidase and related enzymes; TMAO/DMSO reductase 2058293 13699477 O3K_09755 Escherichia coli O104:H4 str. 2011C-3493 TMAO/DMSO reductase YP_006778648.1 2057289 R 1133852 CDS YP_006778649.1 407481500 13699478 complement(2058402..2058815) 1 NC_018658.1 COG2351 Transthyretin-like protein; hydroxyisourate hydrolase 2058815 13699478 O3K_09760 Escherichia coli O104:H4 str. 2011C-3493 hydroxyisourate hydrolase YP_006778649.1 2058402 R 1133852 CDS YP_006778650.1 407481501 13699479 2058948..2059619 1 NC_018658.1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; transcriptional regulatory protein YedW 2059619 13699479 O3K_09765 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulatory protein YedW YP_006778650.1 2058948 D 1133852 CDS YP_006778651.1 407481502 13699480 2059619..2060977 1 NC_018658.1 COG0642 Signal transduction histidine kinase; sensory kinase in two-component regulatory system with YedW 2060977 13699480 O3K_09770 Escherichia coli O104:H4 str. 2011C-3493 sensory kinase in two-component regulatory system with YedW YP_006778651.1 2059619 D 1133852 CDS YP_006778652.1 407481503 13699481 complement(2061075..2061926) 1 NC_018658.1 COG0693 Putative intracellular protease/amidase; chaperone protein HchA 2061926 13699481 O3K_09775 Escherichia coli O104:H4 str. 2011C-3493 chaperone protein HchA YP_006778652.1 2061075 R 1133852 CDS YP_006778653.1 407481504 13699482 2062012..2062287 1 NC_018658.1 COG3677 Transposase and inactivated derivatives; IS1 repressor protein InsA 2062287 13699482 O3K_09780 Escherichia coli O104:H4 str. 2011C-3493 IS1 repressor protein InsA YP_006778653.1 2062012 D 1133852 CDS YP_006778654.1 407481505 13699483 2062206..2062709 1 NC_018658.1 COG1662 Transposase and inactivated derivatives, IS1 family; putative IS1 transposase InsAB' 2062709 13699483 O3K_09785 Escherichia coli O104:H4 str. 2011C-3493 putative IS1 transposase InsAB' YP_006778654.1 2062206 D 1133852 CDS YP_006778655.1 407481506 13699484 complement(2063215..2063901) 1 NC_018658.1 COG2801 Transposase and inactivated derivatives; hypothetical protein 2063901 13699484 O3K_09790 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778655.1 2063215 R 1133852 CDS YP_006778656.1 407481507 13699485 complement(2063843..2064034) 1 NC_018658.1 COG2801 Transposase and inactivated derivatives; hypothetical protein 2064034 13699485 O3K_09795 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778656.1 2063843 R 1133852 CDS YP_006778657.1 407481508 13699486 2064174..2065325 1 NC_018658.1 COG2826 Transposase and inactivated derivatives, IS30 family; transposase for IS30 2065325 13699486 O3K_09800 Escherichia coli O104:H4 str. 2011C-3493 transposase for IS30 YP_006778657.1 2064174 D 1133852 CDS YP_006778658.1 407481509 13699487 complement(2065245..2065595) 1 NC_018658.1 COG2963 Transposase and inactivated derivatives; hypothetical protein 2065595 13699487 O3K_09805 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778658.1 2065245 R 1133852 CDS YP_006778659.1 407481510 13699488 2067272..2067637 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; inner membrane protein 2067637 13699488 O3K_09820 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006778659.1 2067272 D 1133852 CDS YP_006778660.1 407481511 13699489 2067677..2068372 1 NC_018658.1 COG1418 Predicted HD superfamily hydrolase; hydrolase 2068372 13699489 O3K_09825 Escherichia coli O104:H4 str. 2011C-3493 hydrolase YP_006778660.1 2067677 D 1133852 CDS YP_006778661.1 407481512 13699490 2068439..2069857 1 NC_018658.1 COG0270 Site-specific DNA methylase; DNA cytosine methylase 2069857 13699490 O3K_09830 Escherichia coli O104:H4 str. 2011C-3493 DNA cytosine methylase YP_006778661.1 2068439 D 1133852 CDS YP_006778662.1 407481513 13699491 2069838..2070308 1 NC_018658.1 COG3727 DNA G:T-mismatch repair endonuclease; very short patch repair protein 2070308 13699491 O3K_09835 Escherichia coli O104:H4 str. 2011C-3493 very short patch repair protein YP_006778662.1 2069838 D 1133852 CDS YP_006778663.1 407481514 13699492 complement(2070297..2071217) 1 NC_018658.1 COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; putative DMT superfamily transporter inner membrane protein 2071217 13699492 O3K_09840 Escherichia coli O104:H4 str. 2011C-3493 putative DMT superfamily transporter inner membrane protein YP_006778663.1 2070297 R 1133852 CDS YP_006778664.1 407481515 13699493 2071390..2072307 1 NC_018658.1 COG2354 Uncharacterized protein conserved in bacteria; hypothetical protein 2072307 13699493 O3K_09845 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778664.1 2071390 D 1133852 CDS YP_006778665.1 407481516 13699494 2072386..2072568 1 NC_018658.1 COG5475 Uncharacterized small protein; hypothetical protein 2072568 13699494 O3K_09850 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778665.1 2072386 D 1133852 CDS YP_006778666.1 407481517 13699495 2072757..2073674 1 NC_018658.1 diguanylate cyclase 2073674 13699495 O3K_09855 Escherichia coli O104:H4 str. 2011C-3493 diguanylate cyclase YP_006778666.1 2072757 D 1133852 CDS YP_006778667.1 407481518 13699496 2073678..2074433 1 NC_018658.1 COG2199 FOG: GGDEF domain; diguanylate cyclase 2074433 13699496 O3K_09860 Escherichia coli O104:H4 str. 2011C-3493 diguanylate cyclase YP_006778667.1 2073678 D 1133852 CDS YP_006778668.1 407481519 13699497 complement(2074430..2075245) 1 NC_018658.1 COG3769 Predicted hydrolase (HAD superfamily); mannosyl-3-phosphoglycerate phosphatase 2075245 13699497 O3K_09865 Escherichia coli O104:H4 str. 2011C-3493 mannosyl-3-phosphoglycerate phosphatase YP_006778668.1 2074430 R 1133852 CDS YP_006778669.1 407481520 13699498 complement(2075544..2075771) 1 NC_018658.1 hypothetical protein 2075771 13699498 O3K_09870 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778669.1 2075544 R 1133852 CDS YP_006778670.1 407481521 13699499 2075934..2076122 1 NC_018658.1 hypothetical protein 2076122 13699499 O3K_09875 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778670.1 2075934 D 1133852 CDS YP_006778671.1 407481522 13699500 complement(2076166..2076789) 1 NC_018658.1 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; colanic acid capsular biosynthesis activation protein A 2076789 rcsA 13699500 rcsA Escherichia coli O104:H4 str. 2011C-3493 colanic acid capsular biosynthesis activation protein A YP_006778671.1 2076166 R 1133852 CDS YP_006778672.1 407481523 13699501 complement(2077079..2077864) 1 NC_018658.1 COG1684 Flagellar biosynthesis pathway, component FliR; flagellar biosynthesis protein FliR 2077864 fliR 13699501 fliR Escherichia coli O104:H4 str. 2011C-3493 flagellar biosynthesis protein FliR YP_006778672.1 2077079 R 1133852 CDS YP_006778673.1 407481524 13699502 complement(2077873..2078142) 1 NC_018658.1 COG1987 Flagellar biosynthesis pathway, component FliQ; flagellar biosynthesis protein FliQ 2078142 fliQ 13699502 fliQ Escherichia coli O104:H4 str. 2011C-3493 flagellar biosynthesis protein FliQ YP_006778673.1 2077873 R 1133852 CDS YP_006778674.1 407481525 13699503 complement(2078152..2078889) 1 NC_018658.1 COG1338 Flagellar biosynthesis pathway, component FliP; flagellar biosynthesis protein FliP 2078889 fliP 13699503 fliP Escherichia coli O104:H4 str. 2011C-3493 flagellar biosynthesis protein FliP YP_006778674.1 2078152 R 1133852 CDS YP_006778675.1 407481526 13699504 complement(2078889..2079254) 1 NC_018658.1 COG3190 Flagellar biogenesis protein; flagellar biosynthesis protein FliO 2079254 13699504 O3K_09900 Escherichia coli O104:H4 str. 2011C-3493 flagellar biosynthesis protein FliO YP_006778675.1 2078889 R 1133852 CDS YP_006778676.1 407481527 13699505 complement(2079257..2079670) 1 NC_018658.1 COG1886 Flagellar motor switch/type III secretory pathway protein; flagellar motor switch protein FliN 2079670 fliN 13699505 fliN Escherichia coli O104:H4 str. 2011C-3493 flagellar motor switch protein FliN YP_006778676.1 2079257 R 1133852 CDS YP_006778677.1 407481528 13699506 complement(2079667..2080671) 1 NC_018658.1 COG1868 Flagellar motor switch protein; flagellar motor switch protein FliM 2080671 fliM 13699506 fliM Escherichia coli O104:H4 str. 2011C-3493 flagellar motor switch protein FliM YP_006778677.1 2079667 R 1133852 CDS YP_006778678.1 407481529 13699507 complement(2080676..2081140) 1 NC_018658.1 COG1580 Flagellar basal body-associated protein; flagellar basal body-associated protein FliL 2081140 fliL 13699507 fliL Escherichia coli O104:H4 str. 2011C-3493 flagellar basal body-associated protein FliL YP_006778678.1 2080676 R 1133852 CDS YP_006778679.1 407481530 13699508 complement(2081245..2082372) 1 NC_018658.1 COG3144 Flagellar hook-length control protein; flagellar hook-length control protein 2082372 13699508 O3K_09920 Escherichia coli O104:H4 str. 2011C-3493 flagellar hook-length control protein YP_006778679.1 2081245 R 1133852 CDS YP_006778680.1 407481531 13699509 complement(2082369..2082812) 1 NC_018658.1 COG2882 Flagellar biosynthesis chaperone; flagellar biosynthesis chaperone 2082812 fliJ 13699509 fliJ Escherichia coli O104:H4 str. 2011C-3493 flagellar biosynthesis chaperone YP_006778680.1 2082369 R 1133852 CDS YP_006778681.1 407481532 13699510 complement(2082831..2084204) 1 NC_018658.1 COG1157 Flagellar biosynthesis/type III secretory pathway ATPase; flagellum-specific ATP synthase 2084204 fliI 13699510 fliI Escherichia coli O104:H4 str. 2011C-3493 flagellum-specific ATP synthase YP_006778681.1 2082831 R 1133852 CDS YP_006778682.1 407481533 13699511 complement(2084204..2084890) 1 NC_018658.1 COG1317 Flagellar biosynthesis/type III secretory pathway protein; flagellar assembly protein H 2084890 fliH 13699511 fliH Escherichia coli O104:H4 str. 2011C-3493 flagellar assembly protein H YP_006778682.1 2084204 R 1133852 CDS YP_006778683.1 407481534 13699512 complement(2084883..2085878) 1 NC_018658.1 COG1536 Flagellar motor switch protein; flagellar motor switch protein G 2085878 fliG 13699512 fliG Escherichia coli O104:H4 str. 2011C-3493 flagellar motor switch protein G YP_006778683.1 2084883 R 1133852 CDS YP_006778684.1 407481535 13699513 complement(2085871..2087529) 1 NC_018658.1 COG1766 Flagellar biosynthesis/type III secretory pathway lipoprotein; flagellar MS-ring protein 2087529 fliF 13699513 fliF Escherichia coli O104:H4 str. 2011C-3493 flagellar MS-ring protein YP_006778684.1 2085871 R 1133852 CDS YP_006778685.1 407481536 13699514 2087744..2088058 1 NC_018658.1 COG1677 Flagellar hook-basal body protein; flagellar hook-basal body protein FliE 2088058 fliE 13699514 fliE Escherichia coli O104:H4 str. 2011C-3493 flagellar hook-basal body protein FliE YP_006778685.1 2087744 D 1133852 CDS YP_006778686.1 407481537 13699515 2088402..2088734 1 NC_018658.1 COG2076 Membrane transporters of cations and cationic drugs; multidrug efflux protein 2088734 emrE 13699515 emrE Escherichia coli O104:H4 str. 2011C-3493 multidrug efflux protein YP_006778686.1 2088402 D 1133852 CDS YP_006778687.1 407481538 13699516 2088903..2089454 1 NC_018658.1 COG1881 Phospholipid-binding protein; putative kinase inhibitor 2089454 13699516 O3K_09960 Escherichia coli O104:H4 str. 2011C-3493 putative kinase inhibitor YP_006778687.1 2088903 D 1133852 CDS YP_006778688.1 407481539 13699517 2089464..2090261 1 NC_018658.1 COG2207 AraC-type DNA-binding domain-containing proteins; DNA-binding transcriptional regulator, DLP12 prophage 2090261 13699517 O3K_09965 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator, DLP12 prophage YP_006778688.1 2089464 D 1133852 CDS YP_006778689.1 407481540 13699518 complement(2090418..2090987) 1 NC_018658.1 COG1943 Transposase and inactivated derivatives; IS609 family protein; transposase ORF A, IS609 family protein 2090987 13699518 O3K_09970 Escherichia coli O104:H4 str. 2011C-3493 transposase ORF A, IS609 family protein YP_006778689.1 2090418 R 1133852 CDS YP_006778690.1 407481541 13699519 complement(2091176..2091673) 1 NC_018658.1 COG2135 Uncharacterized conserved protein; hypothetical protein 2091673 13699519 O3K_09975 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778690.1 2091176 R 1133852 CDS YP_006778691.1 407481542 13699520 complement(2091782..2092015) 1 NC_018658.1 COG0425 Predicted redox protein, regulator of disulfide bond formation; hypothetical protein 2092015 13699520 O3K_09980 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778691.1 2091782 R 1133852 CDS YP_006778692.1 407481543 13699521 complement(2092012..2093217) 1 NC_018658.1 COG2391 Predicted transporter component; inner membrane protein 2093217 13699521 O3K_09985 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006778692.1 2092012 R 1133852 CDS YP_006778693.1 407481544 13699522 2093404..2093817 1 NC_018658.1 lipoprotein 2093817 13699522 O3K_09990 Escherichia coli O104:H4 str. 2011C-3493 lipoprotein YP_006778693.1 2093404 D 1133852 CDS YP_006778694.1 407481545 13699523 complement(2093851..2095338) 1 NC_018658.1 COG0366 Glycosidases; alpha-amylase 2095338 13699523 O3K_09995 Escherichia coli O104:H4 str. 2011C-3493 alpha-amylase YP_006778694.1 2093851 R 1133852 CDS YP_006778695.1 407481546 13699524 complement(2095416..2095781) 1 NC_018658.1 COG1012 NAD-dependent aldehyde dehydrogenases; flagellar biosynthesis protein FliT 2095781 13699524 O3K_10000 Escherichia coli O104:H4 str. 2011C-3493 flagellar biosynthesis protein FliT YP_006778695.1 2095416 R 1133852 CDS YP_006778696.1 407481547 13699525 complement(2095781..2096191) 1 NC_018658.1 COG1516 Flagellin-specific chaperone FliS; flagellar protein FliS 2096191 fliS 13699525 fliS Escherichia coli O104:H4 str. 2011C-3493 flagellar protein FliS YP_006778696.1 2095781 R 1133852 CDS YP_006778697.1 407481548 13699526 complement(2096207..2097622) 1 NC_018658.1 COG1345 Flagellar capping protein; flagellar capping protein 2097622 fliD 13699526 fliD Escherichia coli O104:H4 str. 2011C-3493 flagellar capping protein YP_006778697.1 2096207 R 1133852 CDS YP_006778698.1 407481549 13699527 2097870..2098919 1 NC_018658.1 COG1344 Flagellin and related hook-associated proteins; Flagellin 2098919 13699527 O3K_10015 Escherichia coli O104:H4 str. 2011C-3493 Flagellin YP_006778698.1 2097870 D 1133852 CDS YP_006778699.1 407481550 13699528 2099083..2099802 1 NC_018658.1 COG1191 DNA-directed RNA polymerase specialized sigma subunit; flagellar biosynthesis sigma factor 2099802 fliA 13699528 fliA Escherichia coli O104:H4 str. 2011C-3493 flagellar biosynthesis sigma factor YP_006778699.1 2099083 D 1133852 CDS YP_006778700.1 407481551 13699529 2099848..2100399 1 NC_018658.1 flagella biosynthesis protein FliZ 2100399 13699529 O3K_10025 Escherichia coli O104:H4 str. 2011C-3493 flagella biosynthesis protein FliZ YP_006778700.1 2099848 D 1133852 CDS YP_006778701.1 407481552 13699530 2100487..2101287 1 NC_018658.1 COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; cystine transporter subunit 2101287 13699530 O3K_10030 Escherichia coli O104:H4 str. 2011C-3493 cystine transporter subunit YP_006778701.1 2100487 D 1133852 CDS YP_006778702.1 407481553 13699531 2101392..2102378 1 NC_018658.1 COG2515 1-aminocyclopropane-1-carboxylate deaminase; D-cysteine desulfhydrase 2102378 13699531 O3K_10035 Escherichia coli O104:H4 str. 2011C-3493 D-cysteine desulfhydrase YP_006778702.1 2101392 D 1133852 CDS YP_006778703.1 407481554 13699532 2102393..2103061 1 NC_018658.1 COG0765 ABC-type amino acid transport system, permease component; amino acid ABC transporter permease 2103061 13699532 O3K_10040 Escherichia coli O104:H4 str. 2011C-3493 amino acid ABC transporter permease YP_006778703.1 2102393 D 1133852 CDS YP_006778704.1 407481555 13699533 2103058..2103810 1 NC_018658.1 COG1126 ABC-type polar amino acid transport system, ATPase component; amino-acid ABC transporter ATP-binding protein YecC 2103810 13699533 O3K_10045 Escherichia coli O104:H4 str. 2011C-3493 amino-acid ABC transporter ATP-binding protein YecC YP_006778704.1 2103058 D 1133852 CDS YP_006778705.1 407481556 13699534 2104040..2104762 1 NC_018658.1 COG2771 DNA-binding HTH domain-containing proteins; DNA-binding transcriptional activator SdiA 2104762 13699534 O3K_10050 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional activator SdiA YP_006778705.1 2104040 D 1133852 CDS YP_006778706.1 407481557 13699535 complement(2104830..2105054) 1 NC_018658.1 hypothetical protein 2105054 13699535 O3K_10055 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778706.1 2104830 R 1133852 CDS YP_006778707.1 407481558 13699536 complement(2105041..2105217) 1 NC_018658.1 hypothetical protein 2105217 13699536 O3K_10060 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778707.1 2105041 R 1133852 CDS YP_006778708.1 407481559 13699537 2105513..2106169 1 NC_018658.1 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; response regulator 2106169 13699537 O3K_10065 Escherichia coli O104:H4 str. 2011C-3493 response regulator YP_006778708.1 2105513 D 1133852 CDS YP_006778709.1 407481560 13699538 2106166..2107998 1 NC_018658.1 COG0322 Nuclease subunit of the excinuclease complex; excinuclease ABC subunit C 2107998 uvrC 13699538 uvrC Escherichia coli O104:H4 str. 2011C-3493 excinuclease ABC subunit C YP_006778709.1 2106166 D 1133852 CDS YP_006778710.1 407481561 13699539 2108055..2108603 1 NC_018658.1 COG0558 Phosphatidylglycerophosphate synthase; phosphatidylglycerophosphate synthetase 2108603 13699539 O3K_10075 Escherichia coli O104:H4 str. 2011C-3493 phosphatidylglycerophosphate synthetase YP_006778710.1 2108055 D 1133852 CDS YP_006778711.1 407481562 13699543 2109253..2109918 1 NC_018658.1 COG3318 Predicted metal-binding protein related to the C-terminal domain of SecA; hypothetical protein 2109918 13699543 O3K_10080 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778711.1 2109253 D 1133852 CDS YP_006778712.1 407481563 13699544 complement(2109980..2111191) 1 NC_018658.1 COG0814 Amino acid permeases; tyrosine transporter TyrP 2111191 13699544 O3K_10085 Escherichia coli O104:H4 str. 2011C-3493 tyrosine transporter TyrP YP_006778712.1 2109980 R 1133852 CDS YP_006778713.1 407481564 13699545 2111381..2111620 1 NC_018658.1 hypothetical protein 2111620 13699545 O3K_10090 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778713.1 2111381 D 1133852 CDS YP_006778714.1 407481565 13699546 complement(2111658..2112155) 1 NC_018658.1 COG1528 Ferritin-like protein; ferritin 2112155 13699546 O3K_10095 Escherichia coli O104:H4 str. 2011C-3493 ferritin YP_006778714.1 2111658 R 1133852 CDS YP_006778715.1 407481566 13699547 complement(2112327..2112650) 1 NC_018658.1 hypothetical protein 2112650 13699547 O3K_10100 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778715.1 2112327 R 1133852 CDS YP_006778716.1 407481567 13699548 2113114..2113365 1 NC_018658.1 hypothetical protein 2113365 13699548 O3K_10105 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778716.1 2113114 D 1133852 CDS YP_006778717.1 407481568 13699549 complement(2113444..2113947) 1 NC_018658.1 COG1528 Ferritin-like protein; ferritin-like protein 2113947 13699549 O3K_10110 Escherichia coli O104:H4 str. 2011C-3493 ferritin-like protein YP_006778717.1 2113444 R 1133852 CDS YP_006778718.1 407481569 13699550 2114744..2115733 1 NC_018658.1 COG1879 ABC-type sugar transport system, periplasmic component; L-arabinose ABC transporter substrate-binding protein 2115733 13699550 O3K_10115 Escherichia coli O104:H4 str. 2011C-3493 L-arabinose ABC transporter substrate-binding protein YP_006778718.1 2114744 D 1133852 CDS YP_006778719.1 407481570 13699551 2115803..2117317 1 NC_018658.1 COG1129 ABC-type sugar transport system, ATPase component; L-arabinose transporter ATP-binding protein 2117317 araG 13699551 araG Escherichia coli O104:H4 str. 2011C-3493 L-arabinose transporter ATP-binding protein YP_006778719.1 2115803 D 1133852 CDS YP_006778720.1 407481571 13699552 2117332..2118318 1 NC_018658.1 COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components; L-arabinose transporter permease 2118318 araH 13699552 araH Escherichia coli O104:H4 str. 2011C-3493 L-arabinose transporter permease YP_006778720.1 2117332 D 1133852 CDS YP_006778721.1 407481572 13699553 2118485..2119285 1 NC_018658.1 COG1877 Trehalose-6-phosphatase; trehalose-6-phosphate phosphatase 2119285 13699553 O3K_10130 Escherichia coli O104:H4 str. 2011C-3493 trehalose-6-phosphate phosphatase YP_006778721.1 2118485 D 1133852 CDS YP_006778722.1 407481573 13699554 2119260..2120684 1 NC_018658.1 COG0380 Trehalose-6-phosphate synthase; trehalose-6-phosphate synthase 2120684 13699554 O3K_10135 Escherichia coli O104:H4 str. 2011C-3493 trehalose-6-phosphate synthase YP_006778722.1 2119260 D 1133852 CDS YP_006778723.1 407481574 13699555 complement(2120691..2121119) 1 NC_018658.1 COG0589 Universal stress protein UspA and related nucleotide-binding proteins; universal stress protein UspC 2121119 13699555 O3K_10140 Escherichia coli O104:H4 str. 2011C-3493 universal stress protein UspC YP_006778723.1 2120691 R 1133852 CDS YP_006778724.1 407481575 13699556 2121898..2122248 1 NC_018658.1 transcriptional activator FlhD 2122248 13699556 O3K_10145 Escherichia coli O104:H4 str. 2011C-3493 transcriptional activator FlhD YP_006778724.1 2121898 D 1133852 CDS YP_006778725.1 407481576 13699557 2122251..2122829 1 NC_018658.1 transcriptional activator FlhC 2122829 13699557 O3K_10150 Escherichia coli O104:H4 str. 2011C-3493 transcriptional activator FlhC YP_006778725.1 2122251 D 1133852 CDS YP_006778726.1 407481577 13699558 2122956..2123843 1 NC_018658.1 COG1291 Flagellar motor component; flagellar motor protein MotA 2123843 13699558 O3K_10155 Escherichia coli O104:H4 str. 2011C-3493 flagellar motor protein MotA YP_006778726.1 2122956 D 1133852 CDS YP_006778727.1 407481578 13699559 2123840..2124766 1 NC_018658.1 COG1360 Flagellar motor protein; flagellar motor protein MotB 2124766 motB 13699559 motB Escherichia coli O104:H4 str. 2011C-3493 flagellar motor protein MotB YP_006778727.1 2123840 D 1133852 CDS YP_006778728.1 407481579 13699560 2124771..2126735 1 NC_018658.1 COG0643 Chemotaxis protein histidine kinase and related kinases; chemotaxis protein CheA 2126735 13699560 O3K_10165 Escherichia coli O104:H4 str. 2011C-3493 chemotaxis protein CheA YP_006778728.1 2124771 D 1133852 CDS YP_006778729.1 407481580 13699561 2126756..2127259 1 NC_018658.1 COG0835 Chemotaxis signal transduction protein; purine-binding chemotaxis protein 2127259 13699561 O3K_10170 Escherichia coli O104:H4 str. 2011C-3493 purine-binding chemotaxis protein YP_006778729.1 2126756 D 1133852 CDS YP_006778730.1 407481581 13699562 2127404..2129065 1 NC_018658.1 COG0840 Methyl-accepting chemotaxis protein; methyl-accepting chemotaxis protein II 2129065 13699562 O3K_10175 Escherichia coli O104:H4 str. 2011C-3493 methyl-accepting chemotaxis protein II YP_006778730.1 2127404 D 1133852 CDS YP_006778731.1 407481582 13699563 2129111..2130712 1 NC_018658.1 COG0840 Methyl-accepting chemotaxis protein; methyl-accepting protein IV 2130712 13699563 O3K_10180 Escherichia coli O104:H4 str. 2011C-3493 methyl-accepting protein IV YP_006778731.1 2129111 D 1133852 CDS YP_006778732.1 407481583 13699564 2130731..2131591 1 NC_018658.1 COG1352 Methylase of chemotaxis methyl-accepting proteins; chemotaxis methyltransferase CheR 2131591 13699564 O3K_10185 Escherichia coli O104:H4 str. 2011C-3493 chemotaxis methyltransferase CheR YP_006778732.1 2130731 D 1133852 CDS YP_006778733.1 407481584 13699565 2131594..2132643 1 NC_018658.1 COG2201 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain; chemotaxis-specific methylesterase 2132643 13699565 O3K_10190 Escherichia coli O104:H4 str. 2011C-3493 chemotaxis-specific methylesterase YP_006778733.1 2131594 D 1133852 CDS YP_006778734.1 407481585 13699566 2132658..2133047 1 NC_018658.1 COG0784 FOG: CheY-like receiver; chemotaxis regulatory protein CheY 2133047 13699566 O3K_10195 Escherichia coli O104:H4 str. 2011C-3493 chemotaxis regulatory protein CheY YP_006778734.1 2132658 D 1133852 CDS YP_006778735.1 407481586 13699567 2133058..2133702 1 NC_018658.1 COG3143 Chemotaxis protein; chemotaxis regulator CheZ 2133702 13699567 O3K_10200 Escherichia coli O104:H4 str. 2011C-3493 chemotaxis regulator CheZ YP_006778735.1 2133058 D 1133852 CDS YP_006778736.1 407481587 13699568 2133904..2135052 1 NC_018658.1 COG1377 Flagellar biosynthesis pathway, component FlhB; flagellar biosynthesis protein FlhB 2135052 flhB 13699568 flhB Escherichia coli O104:H4 str. 2011C-3493 flagellar biosynthesis protein FlhB YP_006778736.1 2133904 D 1133852 CDS YP_006778737.1 407481588 13699569 2135045..2137123 1 NC_018658.1 COG1298 Flagellar biosynthesis pathway, component FlhA; flagellar biosynthesis protein FlhA 2137123 flhA 13699569 flhA Escherichia coli O104:H4 str. 2011C-3493 flagellar biosynthesis protein FlhA YP_006778737.1 2135045 D 1133852 CDS YP_006778738.1 407481589 13699570 2137123..2137515 1 NC_018658.1 flagellar protein FlhE 2137515 13699570 O3K_10215 Escherichia coli O104:H4 str. 2011C-3493 flagellar protein FlhE YP_006778738.1 2137123 D 1133852 CDS YP_006778739.1 407481590 13699571 complement(2137635..2138123) 1 NC_018658.1 COG3755 Uncharacterized protein conserved in bacteria; hypothetical protein 2138123 13699571 O3K_10220 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778739.1 2137635 R 1133852 CDS YP_006778740.1 407481591 13699572 complement(2138300..2140033) 1 NC_018658.1 COG0018 Arginyl-tRNA synthetase; arginyl-tRNA synthetase 2140033 argS 13699572 argS Escherichia coli O104:H4 str. 2011C-3493 arginyl-tRNA synthetase YP_006778740.1 2138300 R 1133852 CDS YP_006778741.1 407481592 13699573 2140249..2140815 1 NC_018658.1 COG3102 Uncharacterized protein conserved in bacteria; hypothetical protein 2140815 13699573 O3K_10230 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778741.1 2140249 D 1133852 CDS YP_006778742.1 407481593 13699574 2140829..2141575 1 NC_018658.1 COG3142 Uncharacterized protein involved in copper resistance; copper homeostasis protein CutC 2141575 13699574 O3K_10235 Escherichia coli O104:H4 str. 2011C-3493 copper homeostasis protein CutC YP_006778742.1 2140829 D 1133852 CDS YP_006778743.1 407481594 13699575 2141963..2143063 1 NC_018658.1 COG3005 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit; TMAO reductase III (TorYZ), cytochrome c-type subunit TorY 2143063 13699575 O3K_10240 Escherichia coli O104:H4 str. 2011C-3493 TMAO reductase III (TorYZ), cytochrome c-type subunit TorY YP_006778743.1 2141963 D 1133852 CDS YP_006778744.1 407481595 13699576 2143088..2145517 1 NC_018658.1 COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; trimethylamine N-oxide reductase system III, catalytic subunit 2145517 13699576 O3K_10245 Escherichia coli O104:H4 str. 2011C-3493 trimethylamine N-oxide reductase system III, catalytic subunit YP_006778744.1 2143088 D 1133852 CDS YP_006778745.1 407481596 13699577 complement(2145683..2146654) 1 NC_018658.1 COG0500 SAM-dependent methyltransferases; tRNA mo(5)U34 methyltransferase 2146654 13699577 O3K_10250 Escherichia coli O104:H4 str. 2011C-3493 tRNA mo(5)U34 methyltransferase YP_006778745.1 2145683 R 1133852 CDS YP_006778746.1 407481597 13699578 complement(2146651..2147394) 1 NC_018658.1 COG0500 SAM-dependent methyltransferases; tRNA cmo(5)U34 methyltransferase 2147394 13699578 O3K_10255 Escherichia coli O104:H4 str. 2011C-3493 tRNA cmo(5)U34 methyltransferase YP_006778746.1 2146651 R 1133852 CDS YP_006778747.1 407481598 13699579 complement(2147435..2147830) 1 NC_018658.1 COG3788 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily; inner membrane protein 2147830 13699579 O3K_10260 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006778747.1 2147435 R 1133852 CDS YP_006778748.1 407481599 13699580 complement(2147883..2148608) 1 NC_018658.1 COG1801 Uncharacterized conserved protein; hypothetical protein 2148608 13699580 O3K_10265 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778748.1 2147883 R 1133852 CDS YP_006778749.1 407481600 13699581 complement(2148635..2149945) 1 NC_018658.1 COG0582 Integrase; integrase 2149945 13699581 O3K_10270 Escherichia coli O104:H4 str. 2011C-3493 integrase YP_006778749.1 2148635 R 1133852 CDS YP_006778750.1 407481601 13699582 complement(2150001..2150237) 1 NC_018658.1 putative excisionase 2150237 13699582 O3K_10275 Escherichia coli O104:H4 str. 2011C-3493 putative excisionase YP_006778750.1 2150001 R 1133852 CDS YP_006778751.1 407481602 13699583 complement(2150246..2150392) 1 NC_018658.1 hypothetical protein 2150392 13699583 O3K_10280 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778751.1 2150246 R 1133852 CDS YP_006778752.1 407481603 13699584 complement(2150396..2150638) 1 NC_018658.1 hypothetical protein 2150638 13699584 O3K_10285 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778752.1 2150396 R 1133852 CDS YP_006778753.1 407481604 13699585 complement(2150723..2151481) 1 NC_018658.1 hypothetical protein 2151481 13699585 O3K_10290 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778753.1 2150723 R 1133852 CDS YP_006778754.1 407481605 13699586 complement(2151478..2151993) 1 NC_018658.1 hypothetical protein 2151993 13699586 O3K_10295 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778754.1 2151478 R 1133852 CDS YP_006778755.1 407481606 13699587 complement(2151995..2152543) 1 NC_018658.1 putative EA22-like protein 2152543 13699587 O3K_10300 Escherichia coli O104:H4 str. 2011C-3493 putative EA22-like protein YP_006778755.1 2151995 R 1133852 CDS YP_006778756.1 407481607 13699588 complement(2152540..2152779) 1 NC_018658.1 hypothetical protein 2152779 13699588 O3K_10305 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778756.1 2152540 R 1133852 CDS YP_006778757.1 407481608 13699589 complement(2152772..2152975) 1 NC_018658.1 hypothetical protein 2152975 13699589 O3K_10310 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778757.1 2152772 R 1133852 CDS YP_006778758.1 407481609 13699590 complement(2152972..2153334) 1 NC_018658.1 CPS-53 (KpLE1) prophage protein 2153334 13699590 O3K_10315 Escherichia coli O104:H4 str. 2011C-3493 CPS-53 (KpLE1) prophage protein YP_006778758.1 2152972 R 1133852 CDS YP_006778759.1 407481610 13699591 complement(2153325..2153861) 1 NC_018658.1 COG1896 Predicted hydrolases of HD superfamily; hypothetical protein 2153861 13699591 O3K_10320 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778759.1 2153325 R 1133852 CDS YP_006778760.1 407481611 13699592 complement(2153989..2154813) 1 NC_018658.1 COG5532 Uncharacterized conserved protein; CPS-53 (KpLE1) prophage protein 2154813 13699592 O3K_10325 Escherichia coli O104:H4 str. 2011C-3493 CPS-53 (KpLE1) prophage protein YP_006778760.1 2153989 R 1133852 CDS YP_006778761.1 407481612 13699593 complement(2155944..2156636) 1 NC_018658.1 COG2932 Predicted transcriptional regulator; putative repressor protein CI 2156636 13699593 O3K_10330 Escherichia coli O104:H4 str. 2011C-3493 putative repressor protein CI YP_006778761.1 2155944 R 1133852 CDS YP_006778762.1 407481613 13699594 2156734..2156994 1 NC_018658.1 COG1396 Predicted transcriptional regulators; hypothetical protein 2156994 13699594 O3K_10335 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778762.1 2156734 D 1133852 CDS YP_006778763.1 407481614 13699595 2156987..2157544 1 NC_018658.1 nucleic acid-binding protein, e14 prophage 2157544 13699595 O3K_10340 Escherichia coli O104:H4 str. 2011C-3493 nucleic acid-binding protein, e14 prophage YP_006778763.1 2156987 D 1133852 CDS YP_006778764.1 407481615 13699596 2157541..2158686 1 NC_018658.1 COG3646 Uncharacterized phage-encoded protein; hypothetical protein 2158686 13699596 O3K_10345 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778764.1 2157541 D 1133852 CDS YP_006778765.1 407481616 13699597 2158683..2158907 1 NC_018658.1 hypothetical protein 2158907 13699597 O3K_10350 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778765.1 2158683 D 1133852 CDS YP_006778766.1 407481617 13699598 2158904..2159722 1 NC_018658.1 replication protein from phage 2159722 13699598 O3K_10355 Escherichia coli O104:H4 str. 2011C-3493 replication protein from phage YP_006778766.1 2158904 D 1133852 CDS YP_006778767.1 407481618 13699599 2159719..2160213 1 NC_018658.1 hypothetical protein 2160213 13699599 O3K_10360 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778767.1 2159719 D 1133852 CDS YP_006778768.1 407481619 13699600 2160213..2160866 1 NC_018658.1 phage AdoMet-dependent methyltransferase 2160866 13699600 O3K_10365 Escherichia coli O104:H4 str. 2011C-3493 phage AdoMet-dependent methyltransferase YP_006778768.1 2160213 D 1133852 CDS YP_006778769.1 407481620 13699601 2160863..2161189 1 NC_018658.1 COG1974 SOS-response transcriptional repressors (RecA-mediated autopeptidases); LexA repressor 2161189 13699601 O3K_10370 Escherichia coli O104:H4 str. 2011C-3493 LexA repressor YP_006778769.1 2160863 D 1133852 CDS YP_006778770.1 407481621 13699602 2161186..2161581 1 NC_018658.1 COG4570 Holliday junction resolvase; putative Crossover junction endodeoxyribonuclease 2161581 13699602 O3K_10375 Escherichia coli O104:H4 str. 2011C-3493 putative Crossover junction endodeoxyribonuclease YP_006778770.1 2161186 D 1133852 CDS YP_006778771.1 407481622 13699603 2161744..2162559 1 NC_018658.1 KilA-N domain family protein 2162559 13699603 O3K_10380 Escherichia coli O104:H4 str. 2011C-3493 KilA-N domain family protein YP_006778771.1 2161744 D 1133852 CDS YP_006778772.1 407481623 13699604 2162561..2163556 1 NC_018658.1 hypothetical protein 2163556 13699604 O3K_10385 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778772.1 2162561 D 1133852 CDS YP_006778773.1 407481624 13699605 2163574..2163915 1 NC_018658.1 antitermination protein from phage origin 2163915 13699605 O3K_10390 Escherichia coli O104:H4 str. 2011C-3493 antitermination protein from phage origin YP_006778773.1 2163574 D 1133852 CDS YP_006778774.1 407481625 13699606 complement(2163928..2164476) 1 NC_018658.1 hypothetical protein 2164476 13699606 O3K_10395 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778774.1 2163928 R 1133852 CDS YP_006778775.1 407481626 13699607 complement(2164463..2165389) 1 NC_018658.1 hypothetical protein 2165389 13699607 O3K_10400 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778775.1 2164463 R 1133852 CDS YP_006778776.1 407481627 13699608 2165654..2165857 1 NC_018658.1 hypothetical protein 2165857 13699608 O3K_10405 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778776.1 2165654 D 1133852 CDS YP_006778777.1 407481628 13699609 2166009..2167058 1 NC_018658.1 COG0863 DNA modification methylase; DNA adenine methyltransferase ( DNA methylase) from phage origin 2167058 13699609 O3K_10410 Escherichia coli O104:H4 str. 2011C-3493 DNA adenine methyltransferase ( DNA methylase) from phage origin YP_006778777.1 2166009 D 1133852 CDS YP_006778778.1 407481629 13699613 2167850..2169703 1 NC_018658.1 hypothetical protein 2169703 13699613 O3K_10415 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778778.1 2167850 D 1133852 CDS YP_006778779.1 407481630 13699614 2169854..2170069 1 NC_018658.1 lysis protein S of prophage CP-933V 2170069 13699614 O3K_10420 Escherichia coli O104:H4 str. 2011C-3493 lysis protein S of prophage CP-933V YP_006778779.1 2169854 D 1133852 CDS YP_006778780.1 407481631 13699615 2170074..2170880 1 NC_018658.1 phage protein 2170880 13699615 O3K_10425 Escherichia coli O104:H4 str. 2011C-3493 phage protein YP_006778780.1 2170074 D 1133852 CDS YP_006778781.1 407481632 13699616 complement(2170890..2171204) 1 NC_018658.1 hypothetical protein 2171204 13699616 O3K_10430 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778781.1 2170890 R 1133852 CDS YP_006778782.1 407481633 13699617 2171333..2171866 1 NC_018658.1 COG3772 Phage-related lysozyme (muraminidase); membrane-associated lysozyme, Qin prophage 2171866 13699617 O3K_10435 Escherichia coli O104:H4 str. 2011C-3493 membrane-associated lysozyme, Qin prophage YP_006778782.1 2171333 D 1133852 CDS YP_006778783.1 407481634 13699618 2172023..2172205 1 NC_018658.1 hypothetical protein 2172205 13699618 O3K_10440 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778783.1 2172023 D 1133852 CDS YP_006778784.1 407481635 13699619 2172220..2172351 1 NC_018658.1 hypothetical protein 2172351 13699619 O3K_10445 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778784.1 2172220 D 1133852 CDS YP_006778785.1 407481636 13699620 2172363..2172821 1 NC_018658.1 Endopeptidase from bacteriophage origin 2172821 13699620 O3K_10450 Escherichia coli O104:H4 str. 2011C-3493 Endopeptidase from bacteriophage origin YP_006778785.1 2172363 D 1133852 CDS YP_006778786.1 407481637 13699621 2173172..2173312 1 NC_018658.1 hypothetical protein 2173312 13699621 O3K_10455 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778786.1 2173172 D 1133852 CDS YP_006778787.1 407481638 13699622 complement(2173445..2173630) 1 NC_018658.1 hypothetical protein 2173630 13699622 O3K_10460 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778787.1 2173445 R 1133852 CDS YP_006778788.1 407481639 13699623 complement(2173646..2173801) 1 NC_018658.1 hypothetical protein 2173801 13699623 O3K_10465 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778788.1 2173646 R 1133852 CDS YP_006778789.1 407481640 13699624 2174025..2174573 1 NC_018658.1 COG4220 Phage DNA packaging protein, Nu1 subunit of terminase; prophage Qin DNA packaging protein NU1-like protein 2174573 13699624 O3K_10470 Escherichia coli O104:H4 str. 2011C-3493 prophage Qin DNA packaging protein NU1-like protein YP_006778789.1 2174025 D 1133852 CDS YP_006778790.1 407481641 13699625 2174545..2176473 1 NC_018658.1 COG5525 Bacteriophage tail assembly protein; DNA packaging protein of prophage 2176473 13699625 O3K_10475 Escherichia coli O104:H4 str. 2011C-3493 DNA packaging protein of prophage YP_006778790.1 2174545 D 1133852 CDS YP_006778791.1 407481642 13699626 2176457..2176663 1 NC_018658.1 head completion protein 2176663 13699626 O3K_10480 Escherichia coli O104:H4 str. 2011C-3493 head completion protein YP_006778791.1 2176457 D 1133852 CDS YP_006778792.1 407481643 13699627 2176660..2178252 1 NC_018658.1 COG5511 Bacteriophage capsid protein; head protein Gp4 2178252 13699627 O3K_10485 Escherichia coli O104:H4 str. 2011C-3493 head protein Gp4 YP_006778792.1 2176660 D 1133852 CDS YP_006778793.1 407481644 13699628 2178242..2179747 1 NC_018658.1 COG0616 Periplasmic serine proteases (ClpP class); Head-tail preconnector protein GP5 (Contains: Scaffold protein GP6 (Head protein GP6)) 2179747 13699628 O3K_10490 Escherichia coli O104:H4 str. 2011C-3493 Head-tail preconnector protein GP5 (Contains: Scaffold protein GP6 (Head protein GP6)) YP_006778793.1 2178242 D 1133852 CDS YP_006778794.1 407481645 13699629 2179784..2180131 1 NC_018658.1 putative head-DNA stabilization protein 2180131 13699629 O3K_10495 Escherichia coli O104:H4 str. 2011C-3493 putative head-DNA stabilization protein YP_006778794.1 2179784 D 1133852 CDS YP_006778795.1 407481646 13699630 2180189..2181217 1 NC_018658.1 Major head protein (Head protein gp7) 2181217 13699630 O3K_10500 Escherichia coli O104:H4 str. 2011C-3493 Major head protein (Head protein gp7) YP_006778795.1 2180189 D 1133852 CDS YP_006778796.1 407481647 13699631 2181269..2181652 1 NC_018658.1 putative DNA packaging protein 2181652 13699631 O3K_10505 Escherichia coli O104:H4 str. 2011C-3493 putative DNA packaging protein YP_006778796.1 2181269 D 1133852 CDS YP_006778797.1 407481648 13699632 2181645..2181998 1 NC_018658.1 Tail attachment protein (Minor capsid protein FII) 2181998 13699632 O3K_10510 Escherichia coli O104:H4 str. 2011C-3493 Tail attachment protein (Minor capsid protein FII) YP_006778797.1 2181645 D 1133852 CDS YP_006778798.1 407481649 13699633 2182013..2182588 1 NC_018658.1 minor tail protein Z (GpZ) 2182588 13699633 O3K_10515 Escherichia coli O104:H4 str. 2011C-3493 minor tail protein Z (GpZ) YP_006778798.1 2182013 D 1133852 CDS YP_006778799.1 407481650 13699634 2182585..2182980 1 NC_018658.1 putative minor tail protein 2182980 13699634 O3K_10520 Escherichia coli O104:H4 str. 2011C-3493 putative minor tail protein YP_006778799.1 2182585 D 1133852 CDS YP_006778800.1 407481651 13699635 2182988..2183740 1 NC_018658.1 COG5492 Bacterial surface proteins containing Ig-like domains; Major tail protein V 2183740 13699635 O3K_10525 Escherichia coli O104:H4 str. 2011C-3493 Major tail protein V YP_006778800.1 2182988 D 1133852 CDS YP_006778801.1 407481652 13699636 2183754..2184176 1 NC_018658.1 putative minor tail protein 2184176 13699636 O3K_10530 Escherichia coli O104:H4 str. 2011C-3493 putative minor tail protein YP_006778801.1 2183754 D 1133852 CDS YP_006778802.1 407481653 13699637 2184203..2184616 1 NC_018658.1 putative minor tail protein 2184616 13699637 O3K_10535 Escherichia coli O104:H4 str. 2011C-3493 putative minor tail protein YP_006778802.1 2184203 D 1133852 CDS YP_006778803.1 407481654 13699638 2184597..2187209 1 NC_018658.1 COG5281 Phage-related minor tail protein; tail length tape measure protein 2187209 13699638 O3K_10540 Escherichia coli O104:H4 str. 2011C-3493 tail length tape measure protein YP_006778803.1 2184597 D 1133852 CDS YP_006778804.1 407481655 13699639 2187206..2187535 1 NC_018658.1 COG4718 Phage-related protein; minor tail protein M 2187535 13699639 O3K_10545 Escherichia coli O104:H4 str. 2011C-3493 minor tail protein M YP_006778804.1 2187206 D 1133852 CDS YP_006778805.1 407481656 13699640 2187535..2188233 1 NC_018658.1 COG4672 Phage-related protein; Minor tail protein L 2188233 13699640 O3K_10550 Escherichia coli O104:H4 str. 2011C-3493 Minor tail protein L YP_006778805.1 2187535 D 1133852 CDS YP_006778806.1 407481657 13699641 2188238..2188981 1 NC_018658.1 COG1310 Predicted metal-dependent protease of the PAD1/JAB1 superfamily; tail fiber component K of prophage 2188981 13699641 O3K_10555 Escherichia coli O104:H4 str. 2011C-3493 tail fiber component K of prophage YP_006778806.1 2188238 D 1133852 CDS YP_006778807.1 407481658 13699642 2188879..2189550 1 NC_018658.1 COG4723 Phage-related protein, tail component; tail assembly protein I 2189550 13699642 O3K_10560 Escherichia coli O104:H4 str. 2011C-3493 tail assembly protein I YP_006778807.1 2188879 D 1133852 CDS YP_006778808.1 407481659 13699643 2189611..2193006 1 NC_018658.1 COG4733 Phage-related protein, tail component; Host specificity protein J 2193006 13699643 O3K_10565 Escherichia coli O104:H4 str. 2011C-3493 Host specificity protein J YP_006778808.1 2189611 D 1133852 CDS YP_006778809.1 407481660 13699644 2193074..2193673 1 NC_018658.1 putative outer membrane Lom 2193673 13699644 O3K_10570 Escherichia coli O104:H4 str. 2011C-3493 putative outer membrane Lom YP_006778809.1 2193074 D 1133852 CDS YP_006778810.1 407481661 13699645 2193825..2195363 1 NC_018658.1 tail fiber protein (modular protein) 2195363 13699645 O3K_10575 Escherichia coli O104:H4 str. 2011C-3493 tail fiber protein (modular protein) YP_006778810.1 2193825 D 1133852 CDS YP_006778811.1 407481662 13699646 2195372..2195980 1 NC_018658.1 hypothetical protein 2195980 13699646 O3K_10580 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778811.1 2195372 D 1133852 CDS YP_006778812.1 407481663 13699647 complement(2196519..2196767) 1 NC_018658.1 DNA-damage-inducible protein 2196767 13699647 O3K_10585 Escherichia coli O104:H4 str. 2011C-3493 DNA-damage-inducible protein YP_006778812.1 2196519 R 1133852 CDS YP_006778813.1 407481664 13699648 2196864..2197040 1 NC_018658.1 hypothetical protein 2197040 13699648 O3K_10590 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778813.1 2196864 D 1133852 CDS YP_006778814.1 407481665 13699649 complement(2197122..2197688) 1 NC_018658.1 COG1335 Amidases related to nicotinamidase; hydrolase 2197688 13699649 O3K_10595 Escherichia coli O104:H4 str. 2011C-3493 hydrolase YP_006778814.1 2197122 R 1133852 CDS YP_006778815.1 407481666 13699650 2197998..2199770 1 NC_018658.1 COG0173 Aspartyl-tRNA synthetase; aspartyl-tRNA synthetase 2199770 aspS 13699650 aspS Escherichia coli O104:H4 str. 2011C-3493 aspartyl-tRNA synthetase YP_006778815.1 2197998 D 1133852 CDS YP_006778816.1 407481667 13699651 2199772..2200215 1 NC_018658.1 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; dihydroneopterin triphosphate pyrophosphatase 2200215 nudB 13699651 nudB Escherichia coli O104:H4 str. 2011C-3493 dihydroneopterin triphosphate pyrophosphatase YP_006778816.1 2199772 D 1133852 CDS YP_006778817.1 407481668 13699652 2200244..2200984 1 NC_018658.1 COG0217 Uncharacterized conserved protein; hypothetical protein 2200984 13699652 O3K_10610 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778817.1 2200244 D 1133852 CDS YP_006778818.1 407481669 13699653 2201019..2201540 1 NC_018658.1 COG0817 Holliday junction resolvasome, endonuclease subunit; Holliday junction resolvase 2201540 ruvC 13699653 ruvC Escherichia coli O104:H4 str. 2011C-3493 Holliday junction resolvase YP_006778818.1 2201019 D 1133852 CDS YP_006778819.1 407481670 13699654 complement(2201542..2202144) 1 NC_018658.1 hypothetical protein 2202144 13699654 O3K_10620 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778819.1 2201542 R 1133852 CDS YP_006778820.1 407481671 13699655 2202419..2203030 1 NC_018658.1 COG0632 Holliday junction resolvasome, DNA-binding subunit; Holliday junction DNA helicase RuvA 2203030 ruvA 13699655 ruvA Escherichia coli O104:H4 str. 2011C-3493 Holliday junction DNA helicase RuvA YP_006778820.1 2202419 D 1133852 CDS YP_006778821.1 407481672 13699656 2203039..2204049 1 NC_018658.1 COG2255 Holliday junction resolvasome, helicase subunit; Holliday junction DNA helicase RuvB 2204049 ruvB 13699656 ruvB Escherichia coli O104:H4 str. 2011C-3493 Holliday junction DNA helicase RuvB YP_006778821.1 2203039 D 1133852 CDS YP_006778822.1 407481673 13699657 complement(2204196..2204981) 1 NC_018658.1 COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components; high-affinity zinc transporter membrane protein 2204981 znuB 13699657 znuB Escherichia coli O104:H4 str. 2011C-3493 high-affinity zinc transporter membrane protein YP_006778822.1 2204196 R 1133852 CDS YP_006778823.1 407481674 13699658 complement(2204978..2205733) 1 NC_018658.1 COG1121 ABC-type Mn/Zn transport systems, ATPase component; high-affinity zinc transporter ATPase 2205733 znuC 13699658 znuC Escherichia coli O104:H4 str. 2011C-3493 high-affinity zinc transporter ATPase YP_006778823.1 2204978 R 1133852 CDS YP_006778824.1 407481675 13699659 2205812..2206744 1 NC_018658.1 COG4531 ABC-type Zn2+ transport system, periplasmic component/surface adhesin; high-affinity zinc transporter periplasmic protein 2206744 znuA 13699659 znuA Escherichia coli O104:H4 str. 2011C-3493 high-affinity zinc transporter periplasmic protein YP_006778824.1 2205812 D 1133852 CDS YP_006778825.1 407481676 13699660 2206760..2208082 1 NC_018658.1 COG0739 Membrane proteins related to metalloendopeptidases; peptidase 2208082 13699660 O3K_10650 Escherichia coli O104:H4 str. 2011C-3493 peptidase YP_006778825.1 2206760 D 1133852 CDS YP_006778826.1 407481677 13699661 2208202..2209173 1 NC_018658.1 COG1560 Lauroyl/myristoyl acyltransferase; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase 2209173 13699661 O3K_10655 Escherichia coli O104:H4 str. 2011C-3493 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase YP_006778826.1 2208202 D 1133852 CDS YP_006778827.1 407481678 13699662 complement(2209304..2210746) 1 NC_018658.1 COG0469 Pyruvate kinase; pyruvate kinase 2210746 13699662 O3K_10660 Escherichia coli O104:H4 str. 2011C-3493 pyruvate kinase YP_006778827.1 2209304 R 1133852 CDS YP_006778828.1 407481679 13699663 complement(2210874..2211743) 1 NC_018658.1 COG1737 Transcriptional regulators; DNA-binding transcriptional regulator HexR 2211743 13699663 O3K_10665 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator HexR YP_006778828.1 2210874 R 1133852 CDS YP_006778829.1 407481680 13699664 2211766..2211915 1 NC_018658.1 hypothetical protein 2211915 13699664 O3K_10670 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778829.1 2211766 D 1133852 CDS YP_006778830.1 407481681 13699665 2212081..2213556 1 NC_018658.1 COG0364 Glucose-6-phosphate 1-dehydrogenase; glucose-6-phosphate 1-dehydrogenase 2213556 13699665 O3K_10675 Escherichia coli O104:H4 str. 2011C-3493 glucose-6-phosphate 1-dehydrogenase YP_006778830.1 2212081 D 1133852 CDS YP_006778831.1 407481682 13699666 2213791..2215602 1 NC_018658.1 COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; phosphogluconate dehydratase 2215602 13699666 O3K_10680 Escherichia coli O104:H4 str. 2011C-3493 phosphogluconate dehydratase YP_006778831.1 2213791 D 1133852 CDS YP_006778832.1 407481683 13699667 2215639..2216280 1 NC_018658.1 COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase 2216280 13699667 O3K_10685 Escherichia coli O104:H4 str. 2011C-3493 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase YP_006778832.1 2215639 D 1133852 CDS YP_006778833.1 407481684 13699668 complement(2216336..2217514) 1 NC_018658.1 COG0027 Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase); phosphoribosylglycinamide formyltransferase 2 2217514 purT 13699668 purT Escherichia coli O104:H4 str. 2011C-3493 phosphoribosylglycinamide formyltransferase 2 YP_006778833.1 2216336 R 1133852 CDS YP_006778834.1 407481685 13699669 2217648..2217938 1 NC_018658.1 COG3141 Uncharacterized protein conserved in bacteria; DNA damage-inducible protein YebG 2217938 13699669 O3K_10695 Escherichia coli O104:H4 str. 2011C-3493 DNA damage-inducible protein YebG YP_006778834.1 2217648 D 1133852 CDS YP_006778835.1 407481686 13699670 2218005..2218361 1 NC_018658.1 hypothetical protein 2218361 13699670 O3K_10700 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778835.1 2218005 D 1133852 CDS YP_006778836.1 407481687 13699671 complement(2218518..2218628) 1 NC_018658.1 hypothetical protein 2218628 13699671 O3K_10705 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778836.1 2218518 R 1133852 CDS YP_006778837.1 407481688 13699672 2218688..2219347 1 NC_018658.1 COG2979 Uncharacterized protein conserved in bacteria; hypothetical protein 2219347 13699672 O3K_10710 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778837.1 2218688 D 1133852 CDS YP_006778838.1 407481689 13699673 2219556..2221616 1 NC_018658.1 COG1770 Protease II; protease 2 2221616 13699673 O3K_10715 Escherichia coli O104:H4 str. 2011C-3493 protease 2 YP_006778838.1 2219556 D 1133852 CDS YP_006778839.1 407481690 13699674 complement(2221613..2222275) 1 NC_018658.1 COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases; exodeoxyribonuclease X 2222275 13699674 O3K_10720 Escherichia coli O104:H4 str. 2011C-3493 exodeoxyribonuclease X YP_006778839.1 2221613 R 1133852 CDS YP_006778840.1 407481691 13699675 complement(2222299..2222955) 1 NC_018658.1 COG0388 Predicted amidohydrolase; carbon-nitrogen family hydrolase 2222955 13699675 O3K_10725 Escherichia coli O104:H4 str. 2011C-3493 carbon-nitrogen family hydrolase YP_006778840.1 2222299 R 1133852 CDS YP_006778841.1 407481692 13699676 complement(2223057..2223287) 1 NC_018658.1 DNA polymerase III subunit theta 2223287 13699676 O3K_10730 Escherichia coli O104:H4 str. 2011C-3493 DNA polymerase III subunit theta YP_006778841.1 2223057 R 1133852 CDS YP_006778842.1 407481693 13699677 2223426..2223800 1 NC_018658.1 COG2372 Uncharacterized protein, homolog of Cu resistance protein CopC; hypothetical protein 2223800 13699677 O3K_10735 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778842.1 2223426 D 1133852 CDS YP_006778843.1 407481694 13699678 2223804..2224676 1 NC_018658.1 COG1276 Putative copper export protein; copper resistance protein D 2224676 13699678 O3K_10740 Escherichia coli O104:H4 str. 2011C-3493 copper resistance protein D YP_006778843.1 2223804 D 1133852 CDS YP_006778844.1 407481695 13699679 2224689..2225030 1 NC_018658.1 hypothetical protein 2225030 13699679 O3K_10745 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778844.1 2224689 D 1133852 CDS YP_006778845.1 407481696 13699680 2225115..2225201 1 NC_018658.1 hypothetical protein 2225201 13699680 O3K_10750 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778845.1 2225115 D 1133852 CDS YP_006778846.1 407481697 13699681 2225426..2226082 1 NC_018658.1 COG0639 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases; serine/threonine protein phosphatase 1 2226082 pphA 13699681 pphA Escherichia coli O104:H4 str. 2011C-3493 serine/threonine protein phosphatase 1 YP_006778846.1 2225426 D 1133852 CDS YP_006778847.1 407481698 13699682 complement(2226083..2226274) 1 NC_018658.1 hypothetical protein 2226274 13699682 O3K_10760 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778847.1 2226083 R 1133852 CDS YP_006778848.1 407481699 13699683 complement(2226379..2226615) 1 NC_018658.1 hypothetical protein 2226615 13699683 O3K_10765 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778848.1 2226379 R 1133852 CDS YP_006778849.1 407481700 13699684 complement(2226733..2228172) 1 NC_018658.1 COG0144 tRNA and rRNA cytosine-C5-methylases; rRNA (cytosine-C(5)-)-methyltransferase RsmF 2228172 yebU 13699684 yebU Escherichia coli O104:H4 str. 2011C-3493 rRNA (cytosine-C(5)-)-methyltransferase RsmF YP_006778849.1 2226733 R 1133852 CDS YP_006778850.1 407481701 13699685 complement(2228252..2230885) 1 NC_018658.1 COG3008 Paraquat-inducible protein B; mce-like protein 2230885 13699685 O3K_10775 Escherichia coli O104:H4 str. 2011C-3493 mce-like protein YP_006778850.1 2228252 R 1133852 CDS YP_006778851.1 407481702 13699686 complement(2230854..2232137) 1 NC_018658.1 COG2995 Uncharacterized paraquat-inducible protein A; hypothetical protein 2232137 13699686 O3K_10780 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778851.1 2230854 R 1133852 CDS YP_006778852.1 407481703 13699687 2232267..2232764 1 NC_018658.1 COG1956 GAF domain-containing protein; hypothetical protein 2232764 13699687 O3K_10785 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778852.1 2232267 D 1133852 CDS YP_006778853.1 407481704 13699688 2232861..2233559 1 NC_018658.1 COG3109 Activator of osmoprotectant transporter ProP; ProP expression regulator 2233559 13699688 O3K_10790 Escherichia coli O104:H4 str. 2011C-3493 ProP expression regulator YP_006778853.1 2232861 D 1133852 CDS YP_006778854.1 407481705 13699689 2233579..2235627 1 NC_018658.1 COG0793 Periplasmic protease; carboxy-terminal protease 2235627 13699689 O3K_10795 Escherichia coli O104:H4 str. 2011C-3493 carboxy-terminal protease YP_006778854.1 2233579 D 1133852 CDS YP_006778855.1 407481706 13699690 2235819..2236700 1 NC_018658.1 COG0501 Zn-dependent protease with chaperone function; heat shock protein HtpX 2236700 13699690 O3K_10800 Escherichia coli O104:H4 str. 2011C-3493 heat shock protein HtpX YP_006778855.1 2235819 D 1133852 CDS YP_006778856.1 407481707 13699691 complement(2236746..2238119) 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; transporter 2238119 13699691 O3K_10805 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006778856.1 2236746 R 1133852 CDS YP_006778857.1 407481708 13699692 2238296..2239087 1 NC_018658.1 COG1414 Transcriptional regulator; DNA-binding transcriptional regulator KdgR 2239087 13699692 O3K_10810 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator KdgR YP_006778857.1 2238296 D 1133852 CDS YP_006778858.1 407481709 13699693 complement(2239230..2239469) 1 NC_018658.1 hypothetical protein 2239469 13699693 O3K_10815 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778858.1 2239230 R 1133852 CDS YP_006778859.1 407481710 13699694 2239628..2239771 1 NC_018658.1 PhoPQ regulatory protein 2239771 13699694 O3K_10820 Escherichia coli O104:H4 str. 2011C-3493 PhoPQ regulatory protein YP_006778859.1 2239628 D 1133852 CDS YP_006778860.1 407481711 13699695 2239846..2240133 1 NC_018658.1 hypothetical protein 2240133 13699695 O3K_10825 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778860.1 2239846 D 1133852 CDS YP_006778861.1 407481712 13699696 2240803..2240946 1 NC_018658.1 hypothetical protein 2240946 13699696 O3K_10830 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778861.1 2240803 D 1133852 CDS YP_006778862.1 407481713 13699697 2240959..2241168 1 NC_018658.1 COG1278 Cold shock proteins; cold-shock protein 2241168 13699697 O3K_10835 Escherichia coli O104:H4 str. 2011C-3493 cold-shock protein YP_006778862.1 2240959 D 1133852 CDS YP_006778863.1 407481714 13699698 2241334..2242143 1 NC_018658.1 COG0500 SAM-dependent methyltransferases; 23S rRNA methyltransferase A 2242143 rrmA 13699698 rrmA Escherichia coli O104:H4 str. 2011C-3493 23S rRNA methyltransferase A YP_006778863.1 2241334 D 1133852 CDS YP_006778864.1 407481715 13699699 complement(2242140..2242706) 1 NC_018658.1 COG1971 Predicted membrane protein; hypothetical protein 2242706 13699699 O3K_10845 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778864.1 2242140 R 1133852 CDS YP_006778865.1 407481716 13699700 complement(2243135..2243593) 1 NC_018658.1 COG4811 Predicted membrane protein; hypothetical protein 2243593 13699700 O3K_10850 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778865.1 2243135 R 1133852 CDS YP_006778866.1 407481717 13699701 complement(2243648..2244508) 1 NC_018658.1 COG3716 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID; PTS system mannose-specific transporter subunit IID 2244508 13699701 O3K_10855 Escherichia coli O104:H4 str. 2011C-3493 PTS system mannose-specific transporter subunit IID YP_006778866.1 2243648 R 1133852 CDS YP_006778867.1 407481718 13699702 complement(2244512..2245312) 1 NC_018658.1 COG3715 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC; PTS system mannose-specific transporter subunit IIC 2245312 13699702 O3K_10860 Escherichia coli O104:H4 str. 2011C-3493 PTS system mannose-specific transporter subunit IIC YP_006778867.1 2244512 R 1133852 CDS YP_006778868.1 407481719 13699703 complement(2245375..2246346) 1 NC_018658.1 COG2893 Phosphotransferase system, mannose/fructose-specific component IIA; PTS system mannose-specific transporter subunit IIAB 2246346 13699703 O3K_10865 Escherichia coli O104:H4 str. 2011C-3493 PTS system mannose-specific transporter subunit IIAB YP_006778868.1 2245375 R 1133852 CDS YP_006778869.1 407481720 13699704 2246809..2248365 1 NC_018658.1 COG0861 Membrane protein TerC, possibly involved in tellurium resistance; hypothetical protein 2248365 13699704 O3K_10870 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778869.1 2246809 D 1133852 CDS YP_006778870.1 407481721 13699705 complement(2248369..2249967) 1 NC_018658.1 COG2200 FOG: EAL domain; phosphodiesterase 2249967 13699705 O3K_10875 Escherichia coli O104:H4 str. 2011C-3493 phosphodiesterase YP_006778870.1 2248369 R 1133852 CDS YP_006778871.1 407481722 13699706 complement(2250098..2251462) 1 NC_018658.1 COG1760 L-serine deaminase; L-serine deaminase 2251462 13699706 O3K_10880 Escherichia coli O104:H4 str. 2011C-3493 L-serine deaminase YP_006778871.1 2250098 R 1133852 CDS YP_006778872.1 407481723 13699707 complement(2251646..2252224) 1 NC_018658.1 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; putative NUDIX hydrolase 2252224 13699707 O3K_10885 Escherichia coli O104:H4 str. 2011C-3493 putative NUDIX hydrolase YP_006778872.1 2251646 R 1133852 CDS YP_006778873.1 407481724 13699708 complement(2252228..2253589) 1 NC_018658.1 COG0147 Anthranilate/para-aminobenzoate synthases component I; aminodeoxychorismate synthase subunit I 2253589 pabB 13699708 pabB Escherichia coli O104:H4 str. 2011C-3493 aminodeoxychorismate synthase subunit I YP_006778873.1 2252228 R 1133852 CDS YP_006778874.1 407481725 13699709 2253663..2253842 1 NC_018658.1 COG3140 Uncharacterized protein conserved in bacteria; hypothetical protein 2253842 13699709 O3K_10895 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778874.1 2253663 D 1133852 CDS YP_006778875.1 407481726 13699710 complement(2253962..2254321) 1 NC_018658.1 hypothetical protein 2254321 13699710 O3K_10900 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778875.1 2253962 R 1133852 CDS YP_006778876.1 407481727 13699711 complement(2254684..2255028) 1 NC_018658.1 COG0251 Putative translation initiation inhibitor, yjgF family; hypothetical protein 2255028 13699711 O3K_10905 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778876.1 2254684 R 1133852 CDS YP_006778877.1 407481728 13699712 2255160..2257070 1 NC_018658.1 COG1199 Rad3-related DNA helicases; Helicase c2 2257070 13699712 O3K_10910 Escherichia coli O104:H4 str. 2011C-3493 Helicase c2 YP_006778877.1 2255160 D 1133852 CDS YP_006778878.1 407481729 13699713 2257128..2257823 1 NC_018658.1 COG1214 Inactive homolog of metal-dependent proteases, putative molecular chaperone; peptidase 2257823 13699713 O3K_10915 Escherichia coli O104:H4 str. 2011C-3493 peptidase YP_006778878.1 2257128 D 1133852 CDS YP_006778879.1 407481730 13699714 2257863..2258444 1 NC_018658.1 COG3065 Starvation-inducible outer membrane lipoprotein; outer membrane lipoprotein 2258444 13699714 O3K_10920 Escherichia coli O104:H4 str. 2011C-3493 outer membrane lipoprotein YP_006778879.1 2257863 D 1133852 CDS YP_006778880.1 407481731 13699715 2258649..2260334 1 NC_018658.1 COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II; long-chain-fatty-acid--CoA ligase 2260334 13699715 O3K_10925 Escherichia coli O104:H4 str. 2011C-3493 long-chain-fatty-acid--CoA ligase YP_006778880.1 2258649 D 1133852 CDS YP_006778881.1 407481732 13699716 2260404..2261531 1 NC_018658.1 COG0349 Ribonuclease D; ribonuclease D 2261531 13699716 O3K_10930 Escherichia coli O104:H4 str. 2011C-3493 ribonuclease D YP_006778881.1 2260404 D 1133852 CDS YP_006778882.1 407481733 13699717 complement(2261585..2262550) 1 NC_018658.1 COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1; oxidoreductase 2262550 13699717 O3K_10935 Escherichia coli O104:H4 str. 2011C-3493 oxidoreductase YP_006778882.1 2261585 R 1133852 CDS YP_006778883.1 407481734 13699718 complement(2262606..2263730) 1 NC_018658.1 COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit; dioxygenase subunit alpha yeaW 2263730 13699718 O3K_10940 Escherichia coli O104:H4 str. 2011C-3493 dioxygenase subunit alpha yeaW YP_006778883.1 2262606 R 1133852 CDS YP_006778884.1 407481735 13699719 complement(2263762..2265372) 1 NC_018658.1 COG1292 Choline-glycine betaine transporter; transporter 2265372 13699719 O3K_10945 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006778884.1 2263762 R 1133852 CDS YP_006778885.1 407481736 13699720 complement(2265623..2266708) 1 NC_018658.1 COG0473 Isocitrate/isopropylmalate dehydrogenase; tartrate dehydrogenase 2266708 13699720 O3K_10950 Escherichia coli O104:H4 str. 2011C-3493 tartrate dehydrogenase YP_006778885.1 2265623 R 1133852 CDS YP_006778886.1 407481737 13699721 2266811..2267734 1 NC_018658.1 COG0583 Transcriptional regulator; LysR family transcriptional regulator 2267734 13699721 O3K_10955 Escherichia coli O104:H4 str. 2011C-3493 LysR family transcriptional regulator YP_006778886.1 2266811 D 1133852 CDS YP_006778887.1 407481738 13699722 2267861..2268499 1 NC_018658.1 COG1280 Putative threonine efflux protein; leucine export protein LeuE 2268499 13699722 O3K_10960 Escherichia coli O104:H4 str. 2011C-3493 leucine export protein LeuE YP_006778887.1 2267861 D 1133852 CDS YP_006778888.1 407481739 13699723 2268672..2269031 1 NC_018658.1 COG3615 Uncharacterized protein/domain, possibly involved in tellurite resistance; hypothetical protein 2269031 13699723 O3K_10965 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778888.1 2268672 D 1133852 CDS YP_006778889.1 407481740 13699724 2269035..2269223 1 NC_018658.1 hypothetical protein 2269223 13699724 O3K_10970 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778889.1 2269035 D 1133852 CDS YP_006778890.1 407481741 13699725 2269678..2270886 1 NC_018658.1 COG0675 Transposase and inactivated derivatives; transposase 2270886 13699725 O3K_10975 Escherichia coli O104:H4 str. 2011C-3493 transposase YP_006778890.1 2269678 D 1133852 CDS YP_006778891.1 407481742 13699726 2271113..2271361 1 NC_018658.1 COG2261 Predicted membrane protein; hypothetical protein 2271361 13699726 O3K_10980 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778891.1 2271113 D 1133852 CDS YP_006778892.1 407481743 13699727 complement(2271420..2271494) 1 NC_018658.1 hypothetical protein 2271494 13699727 O3K_10985 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778892.1 2271420 R 1133852 CDS YP_006778893.1 407481744 13699728 complement(2271628..2272653) 1 NC_018658.1 COG2199 FOG: GGDEF domain; diguanylate cyclase 2272653 13699728 O3K_10990 Escherichia coli O104:H4 str. 2011C-3493 diguanylate cyclase YP_006778893.1 2271628 R 1133852 CDS YP_006778894.1 407481745 13699729 2272836..2273090 1 NC_018658.1 COG3042 Putative hemolysin; lipoprotein 2273090 13699729 O3K_10995 Escherichia coli O104:H4 str. 2011C-3493 lipoprotein YP_006778894.1 2272836 D 1133852 CDS YP_006778895.1 407481746 13699730 complement(2273112..2273459) 1 NC_018658.1 COG3189 Uncharacterized conserved protein; hypothetical protein 2273459 13699730 O3K_11000 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778895.1 2273112 R 1133852 CDS YP_006778896.1 407481747 13699731 complement(2273514..2274695) 1 NC_018658.1 COG2807 Cyanate permease; transporter 2274695 13699731 O3K_11005 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006778896.1 2273514 R 1133852 CDS YP_006778897.1 407481748 13699732 2274792..2275613 1 NC_018658.1 COG2207 AraC-type DNA-binding domain-containing proteins; putative DNA-binding transcriptional regulator, ARAC-type 2275613 13699732 O3K_11010 Escherichia coli O104:H4 str. 2011C-3493 putative DNA-binding transcriptional regulator, ARAC-type YP_006778897.1 2274792 D 1133852 CDS YP_006778898.1 407481749 13699733 complement(2275478..2276020) 1 NC_018658.1 COG2707 Predicted membrane protein; inner membrane protein 2276020 13699733 O3K_11015 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006778898.1 2275478 R 1133852 CDS YP_006778899.1 407481750 13699734 2276142..2276294 1 NC_018658.1 hypothetical protein 2276294 13699734 O3K_11020 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778899.1 2276142 D 1133852 CDS YP_006778900.1 407481751 13699735 complement(2276295..2276798) 1 NC_018658.1 COG2606 Uncharacterized conserved protein; hypothetical protein 2276798 13699735 O3K_11025 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778900.1 2276295 R 1133852 CDS YP_006778901.1 407481752 13699736 complement(2276841..2278331) 1 NC_018658.1 COG2199 FOG: GGDEF domain; diguanylate cyclase 2278331 13699736 O3K_11030 Escherichia coli O104:H4 str. 2011C-3493 diguanylate cyclase YP_006778901.1 2276841 R 1133852 CDS YP_006778902.1 407481753 13699737 complement(2278512..2279987) 1 NC_018658.1 COG2199 FOG: GGDEF domain; hypothetical protein 2279987 13699737 O3K_11035 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778902.1 2278512 R 1133852 CDS YP_006778903.1 407481754 13699738 complement(2280134..2281417) 1 NC_018658.1 COG2718 Uncharacterized conserved protein; hypothetical protein 2281417 13699738 O3K_11040 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778903.1 2280134 R 1133852 CDS YP_006778904.1 407481755 13699739 complement(2281530..2283464) 1 NC_018658.1 COG2766 Putative Ser protein kinase; PrkA family serine protein kinase 2283464 13699739 O3K_11045 Escherichia coli O104:H4 str. 2011C-3493 PrkA family serine protein kinase YP_006778904.1 2281530 R 1133852 CDS YP_006778905.1 407481756 13699740 2283900..2284646 1 NC_018658.1 COG3713 Outer membrane protein V; MltA-interacting protein 2284646 13699740 O3K_11050 Escherichia coli O104:H4 str. 2011C-3493 MltA-interacting protein YP_006778905.1 2283900 D 1133852 CDS YP_006778906.1 407481757 13699741 2284736..2285590 1 NC_018658.1 COG0656 Aldo/keto reductases, related to diketogulonate reductase; oxidoreductase 2285590 13699741 O3K_11055 Escherichia coli O104:H4 str. 2011C-3493 oxidoreductase YP_006778906.1 2284736 D 1133852 CDS YP_006778907.1 407481758 13699742 complement(2285641..2286525) 1 NC_018658.1 COG0676 Uncharacterized enzymes related to aldose 1-epimerase; aldose 1-epimerase 2286525 13699742 O3K_11060 Escherichia coli O104:H4 str. 2011C-3493 aldose 1-epimerase YP_006778907.1 2285641 R 1133852 CDS YP_006778908.1 407481759 13699743 complement(2286609..2287604) 1 NC_018658.1 COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; glyceraldehyde-3-phosphate dehydrogenase 2287604 gapA 13699743 gapA Escherichia coli O104:H4 str. 2011C-3493 glyceraldehyde-3-phosphate dehydrogenase YP_006778908.1 2286609 R 1133852 CDS YP_006778909.1 407481760 13699744 2287946..2288359 1 NC_018658.1 COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase; methionine sulfoxide reductase B 2288359 13699744 O3K_11070 Escherichia coli O104:H4 str. 2011C-3493 methionine sulfoxide reductase B YP_006778909.1 2287946 D 1133852 CDS YP_006778910.1 407481761 13699745 2288401..2288673 1 NC_018658.1 COG3139 Uncharacterized protein conserved in bacteria; hypothetical protein 2288673 13699745 O3K_11075 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778910.1 2288401 D 1133852 CDS YP_006778911.1 407481762 13699746 2289043..2290119 1 NC_018658.1 COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases; oxidoreductase zinc-binding dehydrogenase family protein 2290119 13699746 O3K_11080 Escherichia coli O104:H4 str. 2011C-3493 oxidoreductase zinc-binding dehydrogenase family protein YP_006778911.1 2289043 D 1133852 CDS YP_006778912.1 407481763 13699747 2290146..2291525 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; transporter, MFS superfamily protein 2291525 13699747 O3K_11085 Escherichia coli O104:H4 str. 2011C-3493 transporter, MFS superfamily protein YP_006778912.1 2290146 D 1133852 CDS YP_006778913.1 407481764 13699748 2291542..2292585 1 NC_018658.1 COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases; putative iditol dehydrogenase 2292585 13699748 O3K_11090 Escherichia coli O104:H4 str. 2011C-3493 putative iditol dehydrogenase YP_006778913.1 2291542 D 1133852 CDS YP_006778914.1 407481765 13699749 2292606..2293442 1 NC_018658.1 COG0191 Fructose/tagatose bisphosphate aldolase; putative aldolase 2293442 13699749 O3K_11095 Escherichia coli O104:H4 str. 2011C-3493 putative aldolase YP_006778914.1 2292606 D 1133852 CDS YP_006778915.1 407481766 13699750 2293447..2294394 1 NC_018658.1 COG0524 Sugar kinases, ribokinase family; putative kinase 2294394 13699750 O3K_11100 Escherichia coli O104:H4 str. 2011C-3493 putative kinase YP_006778915.1 2293447 D 1133852 CDS YP_006778916.1 407481767 13699751 2294404..2295384 1 NC_018658.1 COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases); oxidoreductase 2295384 13699751 O3K_11105 Escherichia coli O104:H4 str. 2011C-3493 oxidoreductase YP_006778916.1 2294404 D 1133852 CDS YP_006778917.1 407481768 13699752 2295521..2296279 1 NC_018658.1 COG1349 Transcriptional regulators of sugar metabolism; putative DEOR-type transcriptional regulator 2296279 13699752 O3K_11110 Escherichia coli O104:H4 str. 2011C-3493 putative DEOR-type transcriptional regulator YP_006778917.1 2295521 D 1133852 CDS YP_006778918.1 407481769 13699753 2296396..2297754 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; transporter, MFS superfamily protein 2297754 13699753 O3K_11115 Escherichia coli O104:H4 str. 2011C-3493 transporter, MFS superfamily protein YP_006778918.1 2296396 D 1133852 CDS YP_006778919.1 407481770 13699754 complement(2297847..2298488) 1 NC_018658.1 COG1335 Amidases related to nicotinamidase; nicotinamidase/pyrazinamidase 2298488 13699754 O3K_11120 Escherichia coli O104:H4 str. 2011C-3493 nicotinamidase/pyrazinamidase YP_006778919.1 2297847 R 1133852 CDS YP_006778920.1 407481771 13699755 complement(2298499..2299515) 1 NC_018658.1 COG0252 L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D; asparaginase 2299515 ansA 13699755 ansA Escherichia coli O104:H4 str. 2011C-3493 asparaginase YP_006778920.1 2298499 R 1133852 CDS YP_006778921.1 407481772 13699756 complement(2299682..2301538) 1 NC_018658.1 COG0616 Periplasmic serine proteases (ClpP class); protease 4 2301538 13699756 O3K_11130 Escherichia coli O104:H4 str. 2011C-3493 protease 4 YP_006778921.1 2299682 R 1133852 CDS YP_006778922.1 407481773 13699757 2301699..2302250 1 NC_018658.1 COG0778 Nitroreductase; oxidoreductase 2302250 13699757 O3K_11135 Escherichia coli O104:H4 str. 2011C-3493 oxidoreductase YP_006778922.1 2301699 D 1133852 CDS YP_006778923.1 407481774 13699758 2302367..2303410 1 NC_018658.1 COG0709 Selenophosphate synthase; selenophosphate synthetase 2303410 13699758 O3K_11140 Escherichia coli O104:H4 str. 2011C-3493 selenophosphate synthetase YP_006778923.1 2302367 D 1133852 CDS YP_006778924.1 407481775 13699759 2303415..2305376 1 NC_018658.1 COG0550 Topoisomerase IA; DNA topoisomerase III 2305376 13699759 O3K_11145 Escherichia coli O104:H4 str. 2011C-3493 DNA topoisomerase III YP_006778924.1 2303415 D 1133852 CDS YP_006778925.1 407481776 13699760 2305504..2306544 1 NC_018658.1 hypothetical protein 2306544 13699760 O3K_11150 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778925.1 2305504 D 1133852 CDS YP_006778926.1 407481777 13699761 complement(2306661..2308004) 1 NC_018658.1 COG0334 Glutamate dehydrogenase/leucine dehydrogenase; glutamate dehydrogenase 2308004 13699761 O3K_11155 Escherichia coli O104:H4 str. 2011C-3493 glutamate dehydrogenase YP_006778926.1 2306661 R 1133852 CDS YP_006778927.1 407481778 13699762 2308240..2308512 1 NC_018658.1 hypothetical protein 2308512 13699762 O3K_11160 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778927.1 2308240 D 1133852 CDS YP_006778928.1 407481779 13699763 complement(2308478..2308885) 1 NC_018658.1 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase 2308885 13699763 O3K_11165 Escherichia coli O104:H4 str. 2011C-3493 pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase YP_006778928.1 2308478 R 1133852 CDS YP_006778929.1 407481780 13699764 2308972..2309592 1 NC_018658.1 COG0558 Phosphatidylglycerophosphate synthase; putative phosphatidyl transferase, inner membrane protein 2309592 13699764 O3K_11170 Escherichia coli O104:H4 str. 2011C-3493 putative phosphatidyl transferase, inner membrane protein YP_006778929.1 2308972 D 1133852 CDS YP_006778930.1 407481781 13699765 complement(2309601..2310908) 1 NC_018658.1 COG2897 Rhodanese-related sulfurtransferase; thiosulfate sulfur transferase / thiosulfate binding protein 2310908 13699765 O3K_11175 Escherichia coli O104:H4 str. 2011C-3493 thiosulfate sulfur transferase / thiosulfate binding protein YP_006778930.1 2309601 R 1133852 CDS YP_006778931.1 407481782 13699766 complement(2310975..2311628) 1 NC_018658.1 COG4136 ABC-type uncharacterized transport system, ATPase component; putative transporter subunit 2311628 13699766 O3K_11180 Escherichia coli O104:H4 str. 2011C-3493 putative transporter subunit YP_006778931.1 2310975 R 1133852 CDS YP_006778932.1 407481783 13699767 complement(2311628..2313163) 1 NC_018658.1 COG4135 ABC-type uncharacterized transport system, permease component; ABC transporter membrane protein 2313163 13699767 O3K_11185 Escherichia coli O104:H4 str. 2011C-3493 ABC transporter membrane protein YP_006778932.1 2311628 R 1133852 CDS YP_006778933.1 407481784 13699768 complement(2313136..2314302) 1 NC_018658.1 COG4134 ABC-type uncharacterized transport system, periplasmic component; hypothetical protein 2314302 13699768 O3K_11190 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778933.1 2313136 R 1133852 CDS YP_006778934.1 407481785 13699769 complement(2314312..2314860) 1 NC_018658.1 COG2128 Uncharacterized conserved protein; carboxymuconolactone decarboxylase family protein 2314860 13699769 O3K_11195 Escherichia coli O104:H4 str. 2011C-3493 carboxymuconolactone decarboxylase family protein YP_006778934.1 2314312 R 1133852 CDS YP_006778935.1 407481786 13699770 complement(2314860..2315567) 1 NC_018658.1 COG0398 Uncharacterized conserved protein; inner membrane protein 2315567 13699770 O3K_11200 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006778935.1 2314860 R 1133852 CDS YP_006778936.1 407481787 13699771 complement(2315581..2316258) 1 NC_018658.1 hypothetical protein 2316258 13699771 O3K_11205 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778936.1 2315581 R 1133852 CDS YP_006778937.1 407481788 13699772 complement(2316263..2316973) 1 NC_018658.1 COG0398 Uncharacterized conserved protein; inner membrane protein 2316973 13699772 O3K_11210 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006778937.1 2316263 R 1133852 CDS YP_006778938.1 407481789 13699773 complement(2317140..2317946) 1 NC_018658.1 COG0708 Exonuclease III; exonuclease III 2317946 13699773 O3K_11215 Escherichia coli O104:H4 str. 2011C-3493 exonuclease III YP_006778938.1 2317140 R 1133852 CDS YP_006778939.1 407481790 13699774 2318392..2319612 1 NC_018658.1 COG4992 Ornithine/acetylornithine aminotransferase; bifunctional succinylornithine transaminase/acetylornithine transaminase 2319612 13699774 O3K_11220 Escherichia coli O104:H4 str. 2011C-3493 bifunctional succinylornithine transaminase/acetylornithine transaminase YP_006778939.1 2318392 D 1133852 CDS YP_006778940.1 407481791 13699775 2319609..2320643 1 NC_018658.1 COG3138 Arginine/ornithine N-succinyltransferase beta subunit; arginine succinyltransferase 2320643 13699775 O3K_11225 Escherichia coli O104:H4 str. 2011C-3493 arginine succinyltransferase YP_006778940.1 2319609 D 1133852 CDS YP_006778941.1 407481792 13699776 2320640..2322118 1 NC_018658.1 COG1012 NAD-dependent aldehyde dehydrogenases; succinylglutamic semialdehyde dehydrogenase 2322118 astD 13699776 astD Escherichia coli O104:H4 str. 2011C-3493 succinylglutamic semialdehyde dehydrogenase YP_006778941.1 2320640 D 1133852 CDS YP_006778942.1 407481793 13699777 2322115..2323458 1 NC_018658.1 COG3724 Succinylarginine dihydrolase; succinylarginine dihydrolase 2323458 13699777 O3K_11235 Escherichia coli O104:H4 str. 2011C-3493 succinylarginine dihydrolase YP_006778942.1 2322115 D 1133852 CDS YP_006778943.1 407481794 13699778 2323451..2324419 1 NC_018658.1 COG2988 Succinylglutamate desuccinylase; succinylglutamate desuccinylase 2324419 13699778 O3K_11240 Escherichia coli O104:H4 str. 2011C-3493 succinylglutamate desuccinylase YP_006778943.1 2323451 D 1133852 CDS YP_006778944.1 407481795 13699779 2324749..2325234 1 NC_018658.1 COG3678 P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein; hypothetical protein 2325234 13699779 O3K_11245 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778944.1 2324749 D 1133852 CDS YP_006778945.1 407481796 13699780 2325437..2326012 1 NC_018658.1 COG3758 Uncharacterized protein conserved in bacteria; hypothetical protein 2326012 13699780 O3K_11250 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778945.1 2325437 D 1133852 CDS YP_006778946.1 407481797 13699781 complement(2325972..2326859) 1 NC_018658.1 COG0322 Nuclease subunit of the excinuclease complex; nucleotide excision repair endonuclease 2326859 13699781 O3K_11255 Escherichia coli O104:H4 str. 2011C-3493 nucleotide excision repair endonuclease YP_006778946.1 2325972 R 1133852 CDS YP_006778947.1 407481798 13699782 2326929..2327078 1 NC_018658.1 hypothetical protein 2327078 13699782 O3K_11260 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778947.1 2326929 D 1133852 CDS YP_006778948.1 407481799 13699783 complement(2327089..2327916) 1 NC_018658.1 COG0171 NAD synthase; NAD synthetase 2327916 nadE 13699783 nadE Escherichia coli O104:H4 str. 2011C-3493 NAD synthetase YP_006778948.1 2327089 R 1133852 CDS YP_006778949.1 407481800 13701484 2328118..2328456 1 NC_018658.1 DNA-binding transcriptional activator OsmE 2328456 13701484 O3K_11270 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional activator OsmE YP_006778949.1 2328118 D 1133852 CDS YP_006778950.1 407481801 13701485 2328755..2329075 1 NC_018658.1 COG1440 Phosphotransferase system cellobiose-specific component IIB; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIB 2329075 13701485 O3K_11275 Escherichia coli O104:H4 str. 2011C-3493 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIB YP_006778950.1 2328755 D 1133852 CDS YP_006778951.1 407481802 13701486 2329160..2330518 1 NC_018658.1 COG1455 Phosphotransferase system cellobiose-specific component IIC; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC 2330518 13701486 O3K_11280 Escherichia coli O104:H4 str. 2011C-3493 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC YP_006778951.1 2329160 D 1133852 CDS YP_006778952.1 407481803 13701487 2330569..2330919 1 NC_018658.1 COG1447 Phosphotransferase system cellobiose-specific component IIA; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIA 2330919 13701487 O3K_11285 Escherichia coli O104:H4 str. 2011C-3493 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIA YP_006778952.1 2330569 D 1133852 CDS YP_006778953.1 407481804 13701488 2330927..2331769 1 NC_018658.1 COG2207 AraC-type DNA-binding domain-containing proteins; DNA-binding transcriptional regulator ChbR 2331769 13701488 O3K_11290 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator ChbR YP_006778953.1 2330927 D 1133852 CDS YP_006778954.1 407481805 13701489 2331874..2333226 1 NC_018658.1 COG1486 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases; cryptic phospho-beta-glucosidase, NAD(P)-binding protein 2333226 13701489 O3K_11295 Escherichia coli O104:H4 str. 2011C-3493 cryptic phospho-beta-glucosidase, NAD(P)-binding protein YP_006778954.1 2331874 D 1133852 CDS YP_006778955.1 407481806 13701490 2333239..2333997 1 NC_018658.1 COG3394 Uncharacterized protein conserved in bacteria; hypothetical protein 2333997 13701490 O3K_11300 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778955.1 2333239 D 1133852 CDS YP_006778956.1 407481807 13701491 complement(2334044..2336305) 1 NC_018658.1 COG0753 Catalase; hydroperoxidase II 2336305 katE 13701491 katE Escherichia coli O104:H4 str. 2011C-3493 hydroperoxidase II YP_006778956.1 2334044 R 1133852 CDS YP_006778957.1 407481808 13701492 2336509..2336751 1 NC_018658.1 cell division modulator 2336751 13701492 O3K_11310 Escherichia coli O104:H4 str. 2011C-3493 cell division modulator YP_006778957.1 2336509 D 1133852 CDS YP_006778958.1 407481809 13701493 complement(2337800..2338780) 1 NC_018658.1 COG3039 Transposase and inactivated derivatives, IS5 family; transposase 2338780 13701493 O3K_11325 Escherichia coli O104:H4 str. 2011C-3493 transposase YP_006778958.1 2337800 R 1133852 CDS YP_006778959.1 407481810 13701494 2338779..2339042 1 NC_018658.1 hypothetical protein; ydjO 2339042 13701494 O3K_11330 Escherichia coli O104:H4 str. 2011C-3493 ydjO YP_006778959.1 2338779 D 1133852 CDS YP_006778960.1 407481811 13701495 complement(2339046..2340437) 1 NC_018658.1 COG1823 Predicted Na+/dicarboxylate symporter; cation-acid symporter 2340437 13701495 O3K_11335 Escherichia coli O104:H4 str. 2011C-3493 cation-acid symporter YP_006778960.1 2339046 R 1133852 CDS YP_006778961.1 407481812 13701496 complement(2340570..2341160) 1 NC_018658.1 COG1988 Predicted membrane-bound metal-dependent hydrolases; inner membrane protein 2341160 13701496 O3K_11340 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006778961.1 2340570 R 1133852 CDS YP_006778962.1 407481813 13701497 complement(2341323..2341991) 1 NC_018658.1 COG0637 Predicted phosphatase/phosphohexomutase; 2-deoxyglucose-6-phosphatase 2341991 13701497 O3K_11345 Escherichia coli O104:H4 str. 2011C-3493 2-deoxyglucose-6-phosphatase YP_006778962.1 2341323 R 1133852 CDS YP_006778963.1 407481814 13701498 2342138..2342674 1 NC_018658.1 inner membrane protein 2342674 13701498 O3K_11350 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006778963.1 2342138 D 1133852 CDS YP_006778964.1 407481815 13701499 complement(2342715..2343575) 1 NC_018658.1 COG3001 Fructosamine-3-kinase; phosphotransferase/kinase 2343575 13701499 O3K_11355 Escherichia coli O104:H4 str. 2011C-3493 phosphotransferase/kinase YP_006778964.1 2342715 R 1133852 CDS YP_006778965.1 407481816 13701500 complement(2343681..2343971) 1 NC_018658.1 hypothetical protein 2343971 13701500 O3K_11360 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778965.1 2343681 R 1133852 CDS YP_006778966.1 407481817 13701501 complement(2344072..2345001) 1 NC_018658.1 COG1105 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB); 6-phosphofructokinase 2345001 13701501 O3K_11365 Escherichia coli O104:H4 str. 2011C-3493 6-phosphofructokinase YP_006778966.1 2344072 R 1133852 CDS YP_006778967.1 407481818 13701502 2345288..2346046 1 NC_018658.1 COG3137 Putative salt-induced outer membrane protein; hypothetical protein 2346046 13701502 O3K_11370 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778967.1 2345288 D 1133852 CDS YP_006778968.1 407481819 13701503 complement(2346099..2346206) 1 NC_018658.1 hypothetical protein 2346206 13701503 O3K_11375 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778968.1 2346099 R 1133852 CDS YP_006778969.1 407481820 13701504 2348804..2350732 1 NC_018658.1 COG0441 Threonyl-tRNA synthetase; threonyl-tRNA synthetase 2350732 thrS 13701504 thrS Escherichia coli O104:H4 str. 2011C-3493 threonyl-tRNA synthetase YP_006778969.1 2348804 D 1133852 CDS YP_006778970.1 407481821 13701505 2350844..2351278 1 NC_018658.1 COG0290 Translation initiation factor 3 (IF-3); translation initiation factor IF-3 2351278 infC 13701505 infC Escherichia coli O104:H4 str. 2011C-3493 translation initiation factor IF-3 YP_006778970.1 2350844 D 1133852 CDS YP_006778971.1 407481822 13701506 2351375..2351572 1 NC_018658.1 COG0291 Ribosomal protein L35; 50S ribosomal protein L35 2351572 rpmI 13701506 rpmI Escherichia coli O104:H4 str. 2011C-3493 50S ribosomal protein L35 YP_006778971.1 2351375 D 1133852 CDS YP_006778972.1 407481823 13701507 2351625..2351981 1 NC_018658.1 COG0292 Ribosomal protein L20; 50S ribosomal protein L20 2351981 rplT 13701507 rplT Escherichia coli O104:H4 str. 2011C-3493 50S ribosomal protein L20 YP_006778972.1 2351625 D 1133852 CDS YP_006778973.1 407481824 13701508 2352431..2353414 1 NC_018658.1 COG0016 Phenylalanyl-tRNA synthetase alpha subunit; phenylalanyl-tRNA synthetase subunit alpha 2353414 pheS 13701508 pheS Escherichia coli O104:H4 str. 2011C-3493 phenylalanyl-tRNA synthetase subunit alpha YP_006778973.1 2352431 D 1133852 CDS YP_006778974.1 407481825 13701509 2353429..2355816 1 NC_018658.1 COG0073 EMAP domain; phenylalanyl-tRNA synthetase subunit beta 2355816 pheT 13701509 pheT Escherichia coli O104:H4 str. 2011C-3493 phenylalanyl-tRNA synthetase subunit beta YP_006778974.1 2353429 D 1133852 CDS YP_006778975.1 407481826 13701510 2355821..2356120 1 NC_018658.1 COG0776 Bacterial nucleoid DNA-binding protein; integration host factor subunit alpha 2356120 ihfA 13701510 ihfA Escherichia coli O104:H4 str. 2011C-3493 integration host factor subunit alpha YP_006778975.1 2355821 D 1133852 CDS YP_006778976.1 407481827 13701511 complement(2356422..2356562) 1 NC_018658.1 hypothetical protein 2356562 13701511 O3K_11425 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778976.1 2356422 R 1133852 CDS YP_006778977.1 407481828 13701512 complement(2356753..2357013) 1 NC_018658.1 COG1327 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains; prophage late promoter activator protein 2357013 13701512 O3K_11430 Escherichia coli O104:H4 str. 2011C-3493 prophage late promoter activator protein YP_006778977.1 2356753 R 1133852 CDS YP_006778978.1 407481829 13701513 complement(2357207..2358187) 1 NC_018658.1 COG3039 Transposase and inactivated derivatives, IS5 family; transposase 2358187 13701513 O3K_11435 Escherichia coli O104:H4 str. 2011C-3493 transposase YP_006778978.1 2357207 R 1133852 CDS YP_006778979.1 407481830 13701514 2358445..2359614 1 NC_018658.1 hypothetical protein 2359614 13701514 O3K_11440 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778979.1 2358445 D 1133852 CDS YP_006778980.1 407481831 13701515 complement(2359706..2360815) 1 NC_018658.1 COG3500 Phage protein D; phage protein D 2360815 13701515 O3K_11445 Escherichia coli O104:H4 str. 2011C-3493 phage protein D YP_006778980.1 2359706 R 1133852 CDS YP_006778981.1 407481832 13701516 2360973..2362157 1 NC_018658.1 COG3497 Phage tail sheath protein FI; tail sheath protein 2362157 13701516 O3K_11450 Escherichia coli O104:H4 str. 2011C-3493 tail sheath protein YP_006778981.1 2360973 D 1133852 CDS YP_006778982.1 407481833 13701517 2362157..2362669 1 NC_018658.1 COG3498 Phage tail tube protein FII; putative tail tube protein 2362669 13701517 O3K_11455 Escherichia coli O104:H4 str. 2011C-3493 putative tail tube protein YP_006778982.1 2362157 D 1133852 CDS YP_006778983.1 407481834 13701518 2362724..2363089 1 NC_018658.1 tail protein 2363089 13701518 O3K_11460 Escherichia coli O104:H4 str. 2011C-3493 tail protein YP_006778983.1 2362724 D 1133852 CDS YP_006778984.1 407481835 13701519 2363017..2363253 1 NC_018658.1 phage tail protein 2363253 13701519 O3K_11465 Escherichia coli O104:H4 str. 2011C-3493 phage tail protein YP_006778984.1 2363017 D 1133852 CDS YP_006778985.1 407481836 13701520 2363240..2366047 1 NC_018658.1 COG5283 Phage-related tail protein; tail protein (modular protein) 2366047 13701520 O3K_11470 Escherichia coli O104:H4 str. 2011C-3493 tail protein (modular protein) YP_006778985.1 2363240 D 1133852 CDS YP_006778986.1 407481837 13701521 2366060..2366548 1 NC_018658.1 COG3499 Phage protein U; tail fiber protein 2366548 13701521 O3K_11475 Escherichia coli O104:H4 str. 2011C-3493 tail fiber protein YP_006778986.1 2366060 D 1133852 CDS YP_006778987.1 407481838 13701522 2366705..2367277 1 NC_018658.1 COG1045 Serine acetyltransferase; acetyltransferase 2367277 13701522 O3K_11480 Escherichia coli O104:H4 str. 2011C-3493 acetyltransferase YP_006778987.1 2366705 D 1133852 CDS YP_006778988.1 407481839 13701523 complement(2367321..2367899) 1 NC_018658.1 putative tail fiber assembly protein 2367899 13701523 O3K_11485 Escherichia coli O104:H4 str. 2011C-3493 putative tail fiber assembly protein YP_006778988.1 2367321 R 1133852 CDS YP_006778989.1 407481840 13701524 complement(2367899..2370031) 1 NC_018658.1 COG5301 Phage-related tail fibre protein; putative side tail fiber protein 2370031 13701524 O3K_11490 Escherichia coli O104:H4 str. 2011C-3493 putative side tail fiber protein YP_006778989.1 2367899 R 1133852 CDS YP_006778990.1 407481841 13701525 complement(2370034..2370564) 1 NC_018658.1 COG4385 Bacteriophage P2-related tail formation protein; putative phage tail protein 2370564 13701525 O3K_11495 Escherichia coli O104:H4 str. 2011C-3493 putative phage tail protein YP_006778990.1 2370034 R 1133852 CDS YP_006778991.1 407481842 13701526 complement(2370557..2371453) 1 NC_018658.1 COG3948 Phage-related baseplate assembly protein; baseplate assembly protein 2371453 13701526 O3K_11500 Escherichia coli O104:H4 str. 2011C-3493 baseplate assembly protein YP_006778991.1 2370557 R 1133852 CDS YP_006778992.1 407481843 13701527 complement(2371457..2371807) 1 NC_018658.1 COG3628 Phage baseplate assembly protein W; phage baseplate assembly protein 2371807 13701527 O3K_11505 Escherichia coli O104:H4 str. 2011C-3493 phage baseplate assembly protein YP_006778992.1 2371457 R 1133852 CDS YP_006778993.1 407481844 13701528 complement(2371804..2372385) 1 NC_018658.1 COG4540 Phage P2 baseplate assembly protein gpV; baseplate assembly protein 2372385 13701528 O3K_11510 Escherichia coli O104:H4 str. 2011C-3493 baseplate assembly protein YP_006778993.1 2371804 R 1133852 CDS YP_006778994.1 407481845 13701529 complement(2372382..2373026) 1 NC_018658.1 phage tail completion protein S 2373026 13701529 O3K_11515 Escherichia coli O104:H4 str. 2011C-3493 phage tail completion protein S YP_006778994.1 2372382 R 1133852 CDS YP_006778995.1 407481846 13701530 complement(2373010..2373477) 1 NC_018658.1 Phage tail completion protein R 2373477 13701530 O3K_11520 Escherichia coli O104:H4 str. 2011C-3493 Phage tail completion protein R YP_006778995.1 2373010 R 1133852 CDS YP_006778996.1 407481847 13701531 complement(2373501..2375381) 1 NC_018658.1 hypothetical protein 2375381 13701531 O3K_11525 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778996.1 2373501 R 1133852 CDS YP_006778997.1 407481848 13701532 complement(2375520..2375927) 1 NC_018658.1 COG0164 Ribonuclease HII; hypothetical protein 2375927 13701532 O3K_11530 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006778997.1 2375520 R 1133852 CDS YP_006778998.1 407481849 13701533 complement(2375924..2376316) 1 NC_018658.1 endolysin 2376316 13701533 O3K_11535 Escherichia coli O104:H4 str. 2011C-3493 endolysin YP_006778998.1 2375924 R 1133852 CDS YP_006778999.1 407481850 13701534 complement(2376313..2376636) 1 NC_018658.1 putative phage holin 2376636 13701534 O3K_11540 Escherichia coli O104:H4 str. 2011C-3493 putative phage holin YP_006778999.1 2376313 R 1133852 CDS YP_006779000.1 407481851 13701535 complement(2376639..2376839) 1 NC_018658.1 COG5004 P2-like prophage tail protein X; phage tail protein 2376839 13701535 O3K_11545 Escherichia coli O104:H4 str. 2011C-3493 phage tail protein YP_006779000.1 2376639 R 1133852 CDS YP_006779001.1 407481852 13701536 complement(2376839..2377333) 1 NC_018658.1 capsid completion protein 2377333 13701536 O3K_11550 Escherichia coli O104:H4 str. 2011C-3493 capsid completion protein YP_006779001.1 2376839 R 1133852 CDS YP_006779002.1 407481853 13701537 complement(2377435..2378235) 1 NC_018658.1 terminase, endonuclease subunit 2378235 13701537 O3K_11555 Escherichia coli O104:H4 str. 2011C-3493 terminase, endonuclease subunit YP_006779002.1 2377435 R 1133852 CDS YP_006779003.1 407481854 13701538 complement(2378281..2379333) 1 NC_018658.1 major capsid protein 2379333 13701538 O3K_11560 Escherichia coli O104:H4 str. 2011C-3493 major capsid protein YP_006779003.1 2378281 R 1133852 CDS YP_006779004.1 407481855 13701539 complement(2379357..2380193) 1 NC_018658.1 capsid scaffolding protein 2380193 13701539 O3K_11565 Escherichia coli O104:H4 str. 2011C-3493 capsid scaffolding protein YP_006779004.1 2379357 R 1133852 CDS YP_006779005.1 407481856 13701540 2380348..2382099 1 NC_018658.1 COG5484 Uncharacterized conserved protein; large subunit terminase 2382099 13701540 O3K_11570 Escherichia coli O104:H4 str. 2011C-3493 large subunit terminase YP_006779005.1 2380348 D 1133852 CDS YP_006779006.1 407481857 13701541 2382099..2383145 1 NC_018658.1 COG5518 Bacteriophage capsid portal protein; capsid portal protein 2383145 13701541 O3K_11575 Escherichia coli O104:H4 str. 2011C-3493 capsid portal protein YP_006779006.1 2382099 D 1133852 CDS YP_006779007.1 407481858 13701542 complement(2383657..2383920) 1 NC_018658.1 hypothetical protein 2383920 13701542 O3K_11580 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779007.1 2383657 R 1133852 CDS YP_006779008.1 407481859 13701543 complement(2383922..2384353) 1 NC_018658.1 hypothetical protein 2384353 13701543 O3K_11585 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779008.1 2383922 R 1133852 CDS YP_006779009.1 407481860 13701544 complement(2384373..2384687) 1 NC_018658.1 plasmid partition protein; modular protein; stability/partitioning protein phage encoded 2384687 13701544 O3K_11590 Escherichia coli O104:H4 str. 2011C-3493 stability/partitioning protein phage encoded YP_006779009.1 2384373 R 1133852 CDS YP_006779010.1 407481861 13701545 complement(2384692..2385651) 1 NC_018658.1 COG0443 Molecular chaperone; prophage stability/partitioning protein 2385651 13701545 O3K_11595 Escherichia coli O104:H4 str. 2011C-3493 prophage stability/partitioning protein YP_006779010.1 2384692 R 1133852 CDS YP_006779011.1 407481862 13701546 complement(2385728..2388568) 1 NC_018658.1 phage replication protein 2388568 13701546 O3K_11600 Escherichia coli O104:H4 str. 2011C-3493 phage replication protein YP_006779011.1 2385728 R 1133852 CDS YP_006779012.1 407481863 13701547 complement(2388565..2388954) 1 NC_018658.1 hypothetical protein 2388954 13701547 O3K_11605 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779012.1 2388565 R 1133852 CDS YP_006779013.1 407481864 13701548 complement(2389027..2389257) 1 NC_018658.1 hypothetical protein 2389257 13701548 O3K_11610 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779013.1 2389027 R 1133852 CDS YP_006779014.1 407481865 13701549 complement(2389580..2389879) 1 NC_018658.1 hypothetical protein 2389879 13701549 O3K_11615 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779014.1 2389580 R 1133852 CDS YP_006779015.1 407481866 13701550 complement(2389876..2390121) 1 NC_018658.1 COG1846 Transcriptional regulators; hypothetical protein 2390121 13701550 O3K_11620 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779015.1 2389876 R 1133852 CDS YP_006779016.1 407481867 13701551 complement(2390118..2390321) 1 NC_018658.1 hypothetical protein 2390321 13701551 O3K_11625 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779016.1 2390118 R 1133852 CDS YP_006779017.1 407481868 13701552 complement(2390311..2390631) 1 NC_018658.1 hypothetical protein 2390631 13701552 O3K_11630 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779017.1 2390311 R 1133852 CDS YP_006779018.1 407481869 13701553 complement(2390720..2390833) 1 NC_018658.1 hypothetical protein 2390833 13701553 O3K_11635 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779018.1 2390720 R 1133852 CDS YP_006779019.1 407481870 13701554 complement(2390830..2391072) 1 NC_018658.1 hypothetical protein 2391072 13701554 O3K_11640 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779019.1 2390830 R 1133852 CDS YP_006779020.1 407481871 13701555 complement(2391084..2391371) 1 NC_018658.1 hypothetical protein 2391371 13701555 O3K_11645 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779020.1 2391084 R 1133852 CDS YP_006779021.1 407481872 13701556 complement(2391382..2391720) 1 NC_018658.1 hypothetical protein 2391720 13701556 O3K_11650 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779021.1 2391382 R 1133852 CDS YP_006779022.1 407481873 13701557 complement(2391735..2392013) 1 NC_018658.1 DNA-binding protein 2392013 13701557 O3K_11655 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding protein YP_006779022.1 2391735 R 1133852 CDS YP_006779023.1 407481874 13701558 2392105..2392416 1 NC_018658.1 COG2944 Predicted transcriptional regulator; repressor protein C 2392416 13701558 O3K_11660 Escherichia coli O104:H4 str. 2011C-3493 repressor protein C YP_006779023.1 2392105 D 1133852 CDS YP_006779024.1 407481875 13701559 2392505..2393440 1 NC_018658.1 COG0582 Integrase; integrase 2393440 13701559 O3K_11665 Escherichia coli O104:H4 str. 2011C-3493 integrase YP_006779024.1 2392505 D 1133852 CDS YP_006779025.1 407481876 13701560 2393451..2393846 1 NC_018658.1 hypothetical protein 2393846 13701560 O3K_11670 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779025.1 2393451 D 1133852 CDS YP_006779026.1 407481877 13701561 2394036..2395016 1 NC_018658.1 COG4139 ABC-type cobalamin transport system, permease component; vtamin B12-transporter permease 2395016 13701561 O3K_11675 Escherichia coli O104:H4 str. 2011C-3493 vtamin B12-transporter permease YP_006779026.1 2394036 D 1133852 CDS YP_006779027.1 407481878 13701562 2395079..2395630 1 NC_018658.1 COG0386 Glutathione peroxidase; glutathione peroxidase 2395630 btuE 13701562 btuE Escherichia coli O104:H4 str. 2011C-3493 glutathione peroxidase YP_006779027.1 2395079 D 1133852 CDS YP_006779028.1 407481879 13701563 2395630..2396379 1 NC_018658.1 COG4138 ABC-type cobalamin transport system, ATPase component; vitamin B12-transporter ATPase 2396379 13701563 O3K_11685 Escherichia coli O104:H4 str. 2011C-3493 vitamin B12-transporter ATPase YP_006779028.1 2395630 D 1133852 CDS YP_006779029.1 407481880 13701564 2396457..2396921 1 NC_018658.1 COG0791 Cell wall-associated hydrolases (invasion-associated proteins); lipoprotein 2396921 13701564 O3K_11690 Escherichia coli O104:H4 str. 2011C-3493 lipoprotein YP_006779029.1 2396457 D 1133852 CDS YP_006779030.1 407481881 13701636 2397168..2397881 1 NC_018658.1 COG2200 FOG: EAL domain; hypothetical protein 2397881 13701636 O3K_11695 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779030.1 2397168 D 1133852 CDS YP_006779031.1 407481882 13701637 2397944..2399380 1 NC_018658.1 COG0397 Uncharacterized conserved protein; hypothetical protein 2399380 13701637 O3K_11700 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779031.1 2397944 D 1133852 CDS YP_006779032.1 407481883 13701638 complement(2399384..2399575) 1 NC_018658.1 COG4256 Hemin uptake protein; hypothetical protein 2399575 13701638 O3K_11705 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779032.1 2399384 R 1133852 CDS YP_006779033.1 407481884 13701639 complement(2399707..2400753) 1 NC_018658.1 COG0722 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; phospho-2-dehydro-3-deoxyheptonate aldolase 2400753 13701639 O3K_11710 Escherichia coli O104:H4 str. 2011C-3493 phospho-2-dehydro-3-deoxyheptonate aldolase YP_006779033.1 2399707 R 1133852 CDS YP_006779034.1 407481885 13701640 complement(2400910..2401743) 1 NC_018658.1 COG1806 Uncharacterized protein conserved in bacteria; PEP synthetase regulatory protein 2401743 13701640 O3K_11715 Escherichia coli O104:H4 str. 2011C-3493 PEP synthetase regulatory protein YP_006779034.1 2400910 R 1133852 CDS YP_006779035.1 407481886 13701641 2402076..2404454 1 NC_018658.1 COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase; phosphoenolpyruvate synthase 2404454 13701641 O3K_11720 Escherichia coli O104:H4 str. 2011C-3493 phosphoenolpyruvate synthase YP_006779035.1 2402076 D 1133852 CDS YP_006779036.1 407481887 13701642 complement(2404511..2406211) 1 NC_018658.1 COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II; short chain acyl-CoA synthetase 2406211 13701642 O3K_11725 Escherichia coli O104:H4 str. 2011C-3493 short chain acyl-CoA synthetase YP_006779036.1 2404511 R 1133852 CDS YP_006779037.1 407481888 13701643 complement(2406214..2406507) 1 NC_018658.1 COG2440 Ferredoxin-like protein; ferredoxin-like protein FixX 2406507 13701643 O3K_11730 Escherichia coli O104:H4 str. 2011C-3493 ferredoxin-like protein FixX YP_006779037.1 2406214 R 1133852 CDS YP_006779038.1 407481889 13701644 complement(2406504..2407793) 1 NC_018658.1 COG0644 Dehydrogenases (flavoproteins); oxidoreductase 2407793 13701644 O3K_11735 Escherichia coli O104:H4 str. 2011C-3493 oxidoreductase YP_006779038.1 2406504 R 1133852 CDS YP_006779039.1 407481890 13701645 complement(2407849..2408787) 1 NC_018658.1 COG2025 Electron transfer flavoprotein, alpha subunit; electron transfer flavoprotein subunit YdiR 2408787 13701645 O3K_11740 Escherichia coli O104:H4 str. 2011C-3493 electron transfer flavoprotein subunit YdiR YP_006779039.1 2407849 R 1133852 CDS YP_006779040.1 407481891 13701646 complement(2408807..2409571) 1 NC_018658.1 COG2086 Electron transfer flavoprotein, beta subunit; hypothetical protein 2409571 13701646 O3K_11745 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779040.1 2408807 R 1133852 CDS YP_006779041.1 407481892 13701647 2409608..2409784 1 NC_018658.1 hypothetical protein 2409784 13701647 O3K_11750 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779041.1 2409608 D 1133852 CDS YP_006779042.1 407481893 13701648 2409887..2410798 1 NC_018658.1 COG2207 AraC-type DNA-binding domain-containing proteins; DNA-binding transcriptional regulator 2410798 13701648 O3K_11755 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator YP_006779042.1 2409887 D 1133852 CDS YP_006779043.1 407481894 13701649 complement(2410841..2411992) 1 NC_018658.1 COG1960 Acyl-CoA dehydrogenases; putative acyl-CoA dehydrogenase 2411992 13701649 O3K_11760 Escherichia coli O104:H4 str. 2011C-3493 putative acyl-CoA dehydrogenase YP_006779043.1 2410841 R 1133852 CDS YP_006779044.1 407481895 13701650 complement(2412006..2413601) 1 NC_018658.1 COG4670 Acyl CoA:acetate/3-ketoacid CoA transferase; acetyl-CoA: acetoacetyl-CoA transferase subunit alpha/beta 2413601 13701650 O3K_11765 Escherichia coli O104:H4 str. 2011C-3493 acetyl-CoA: acetoacetyl-CoA transferase subunit alpha/beta YP_006779044.1 2412006 R 1133852 CDS YP_006779045.1 407481896 13701651 complement(2413745..2414503) 1 NC_018658.1 COG0710 3-dehydroquinate dehydratase; 3-dehydroquinate dehydratase 2414503 aroD 13701651 aroD Escherichia coli O104:H4 str. 2011C-3493 3-dehydroquinate dehydratase YP_006779045.1 2413745 R 1133852 CDS YP_006779046.1 407481897 13701652 complement(2414534..2415400) 1 NC_018658.1 COG0169 Shikimate 5-dehydrogenase; quinate/shikimate dehydrogenase 2415400 13701652 O3K_11775 Escherichia coli O104:H4 str. 2011C-3493 quinate/shikimate dehydrogenase YP_006779046.1 2414534 R 1133852 CDS YP_006779047.1 407481898 13701653 complement(2415412..2416677) 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; transporter 2416677 13701653 O3K_11780 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006779047.1 2415412 R 1133852 CDS YP_006779048.1 407481899 13701654 complement(2416904..2418118) 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; transporter, MFS superfamily protein 2418118 13701654 O3K_11785 Escherichia coli O104:H4 str. 2011C-3493 transporter, MFS superfamily protein YP_006779048.1 2416904 R 1133852 CDS YP_006779049.1 407481900 13701655 complement(2418218..2418574) 1 NC_018658.1 hypothetical protein 2418574 13701655 O3K_11790 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779049.1 2418218 R 1133852 CDS YP_006779050.1 407481901 13701656 complement(2419003..2420115) 1 NC_018658.1 COG0628 Predicted permease; inner membrane protein 2420115 13701656 O3K_11795 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006779050.1 2419003 R 1133852 CDS YP_006779051.1 407481902 13701657 2420504..2423560 1 NC_018658.1 COG0277 FAD/FMN-containing dehydrogenases; putative FAD-linked oxidoreductase 2423560 13701657 O3K_11800 Escherichia coli O104:H4 str. 2011C-3493 putative FAD-linked oxidoreductase YP_006779051.1 2420504 D 1133852 CDS YP_006779052.1 407481903 13701658 2423557..2423967 1 NC_018658.1 COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism; acyl-CoA esterase 2423967 13701658 O3K_11805 Escherichia coli O104:H4 str. 2011C-3493 acyl-CoA esterase YP_006779052.1 2423557 D 1133852 CDS YP_006779053.1 407481904 13701659 2423986..2424255 1 NC_018658.1 hypothetical protein 2424255 13701659 O3K_11810 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779053.1 2423986 D 1133852 CDS YP_006779054.1 407481905 13701660 2424804..2425172 1 NC_018658.1 COG0316 Uncharacterized conserved protein; iron-sulfur cluster assembly scaffold protein 2425172 sufA 13701660 sufA Escherichia coli O104:H4 str. 2011C-3493 iron-sulfur cluster assembly scaffold protein YP_006779054.1 2424804 D 1133852 CDS YP_006779055.1 407481906 13701661 2425181..2426668 1 NC_018658.1 COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component; cysteine desulfurase activator complex subunit SufB 2426668 13701661 O3K_11820 Escherichia coli O104:H4 str. 2011C-3493 cysteine desulfurase activator complex subunit SufB YP_006779055.1 2425181 D 1133852 CDS YP_006779056.1 407481907 13701662 2426678..2427424 1 NC_018658.1 COG0396 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; cysteine desulfurase 2427424 sufC 13701662 sufC Escherichia coli O104:H4 str. 2011C-3493 cysteine desulfurase YP_006779056.1 2426678 D 1133852 CDS YP_006779057.1 407481908 13701663 2427399..2428670 1 NC_018658.1 COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component; cysteine desulfurase activator complex subunit SufD 2428670 13701663 O3K_11830 Escherichia coli O104:H4 str. 2011C-3493 cysteine desulfurase activator complex subunit SufD YP_006779057.1 2427399 D 1133852 CDS YP_006779058.1 407481909 13701664 2428667..2429887 1 NC_018658.1 COG0520 Selenocysteine lyase; bifunctional cysteine desulfurase/selenocysteine lyase 2429887 13701664 O3K_11835 Escherichia coli O104:H4 str. 2011C-3493 bifunctional cysteine desulfurase/selenocysteine lyase YP_006779058.1 2428667 D 1133852 CDS YP_006779059.1 407481910 13701665 2429900..2430316 1 NC_018658.1 COG2166 SufE protein probably involved in Fe-S center assembly; cysteine desufuration protein SufE 2430316 13701665 O3K_11840 Escherichia coli O104:H4 str. 2011C-3493 cysteine desufuration protein SufE YP_006779059.1 2429900 D 1133852 CDS YP_006779060.1 407481911 13701666 2430465..2431469 1 NC_018658.1 COG1376 Uncharacterized protein conserved in bacteria; hypothetical protein 2431469 13701666 O3K_11845 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779060.1 2430465 D 1133852 CDS YP_006779061.1 407481912 13701667 complement(2431533..2431769) 1 NC_018658.1 COG4238 Murein lipoprotein; murein lipoprotein 2431769 13701667 O3K_11850 Escherichia coli O104:H4 str. 2011C-3493 murein lipoprotein YP_006779061.1 2431533 R 1133852 CDS YP_006779062.1 407481913 13701668 complement(2432080..2433492) 1 NC_018658.1 COG0469 Pyruvate kinase; pyruvate kinase 2433492 13701668 O3K_11855 Escherichia coli O104:H4 str. 2011C-3493 pyruvate kinase YP_006779062.1 2432080 R 1133852 CDS YP_006779063.1 407481914 13701669 2434049..2434258 1 NC_018658.1 hypothetical protein 2434258 13701669 O3K_11860 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779063.1 2434049 D 1133852 CDS YP_006779064.1 407481915 13701670 2434714..2435340 1 NC_018658.1 COG0437 Fe-S-cluster-containing hydrogenase components 1; hypothetical protein 2435340 13701670 O3K_11865 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779064.1 2434714 D 1133852 CDS YP_006779065.1 407481916 13701671 2435361..2437463 1 NC_018658.1 COG2414 Aldehyde:ferredoxin oxidoreductase; oxidoreductase 2437463 13701671 O3K_11870 Escherichia coli O104:H4 str. 2011C-3493 oxidoreductase YP_006779065.1 2435361 D 1133852 CDS YP_006779066.1 407481917 13701672 2437467..2438114 1 NC_018658.1 hypothetical protein 2438114 13701672 O3K_11875 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779066.1 2437467 D 1133852 CDS YP_006779067.1 407481918 13701673 2438127..2438846 1 NC_018658.1 COG0437 Fe-S-cluster-containing hydrogenase components 1; oxidoreductase, Fe-S subunit 2438846 13701673 O3K_11880 Escherichia coli O104:H4 str. 2011C-3493 oxidoreductase, Fe-S subunit YP_006779067.1 2438127 D 1133852 CDS YP_006779068.1 407481919 13701674 2438843..2439628 1 NC_018658.1 thiosulfate reductase cytochrome B subunit 2439628 13701674 O3K_11885 Escherichia coli O104:H4 str. 2011C-3493 thiosulfate reductase cytochrome B subunit YP_006779068.1 2438843 D 1133852 CDS YP_006779069.1 407481920 13701675 2439632..2440444 1 NC_018658.1 hypothetical protein 2440444 13701675 O3K_11890 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779069.1 2439632 D 1133852 CDS YP_006779070.1 407481921 13701676 complement(2440456..2442060) 1 NC_018658.1 COG4529 Uncharacterized protein conserved in bacteria; hypothetical protein 2442060 13701676 O3K_11895 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779070.1 2440456 R 1133852 CDS YP_006779071.1 407481922 13701677 complement(2442186..2442491) 1 NC_018658.1 COG0113 Delta-aminolevulinic acid dehydratase; putative monooxygenase 2442491 13701677 O3K_11900 Escherichia coli O104:H4 str. 2011C-3493 putative monooxygenase YP_006779071.1 2442186 R 1133852 CDS YP_006779072.1 407481923 13701680 2443064..2444320 1 NC_018658.1 hypothetical protein 2444320 13701680 O3K_11905 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779072.1 2443064 D 1133852 CDS YP_006779073.1 407481924 13701681 complement(2444361..2445734) 1 NC_018658.1 COG0534 Na+-driven multidrug efflux pump; multidrug efflux protein 2445734 13701681 O3K_11910 Escherichia coli O104:H4 str. 2011C-3493 multidrug efflux protein YP_006779073.1 2444361 R 1133852 CDS YP_006779074.1 407481925 13701682 2445949..2446590 1 NC_018658.1 COG0307 Riboflavin synthase alpha chain; riboflavin synthase subunit alpha 2446590 13701682 O3K_11915 Escherichia coli O104:H4 str. 2011C-3493 riboflavin synthase subunit alpha YP_006779074.1 2445949 D 1133852 CDS YP_006779075.1 407481926 13701683 complement(2446630..2447778) 1 NC_018658.1 COG2230 Cyclopropane fatty acid synthase and related methyltransferases; cyclopropane-fatty-acyl-phospholipid synthase 2447778 13701683 O3K_11920 Escherichia coli O104:H4 str. 2011C-3493 cyclopropane-fatty-acyl-phospholipid synthase YP_006779075.1 2446630 R 1133852 CDS YP_006779076.1 407481927 13701684 complement(2448069..2449280) 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; transporter 2449280 13701684 O3K_11925 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006779076.1 2448069 R 1133852 CDS YP_006779077.1 407481928 13701685 2449393..2450325 1 NC_018658.1 COG0583 Transcriptional regulator; putative DNA-binding transcriptional regulator 2450325 13701685 O3K_11930 Escherichia coli O104:H4 str. 2011C-3493 putative DNA-binding transcriptional regulator YP_006779077.1 2449393 D 1133852 CDS YP_006779078.1 407481929 13701686 complement(2450322..2451347) 1 NC_018658.1 COG1609 Transcriptional regulators; DNA-binding transcriptional repressor PurR 2451347 13701686 O3K_11935 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional repressor PurR YP_006779078.1 2450322 R 1133852 CDS YP_006779079.1 407481930 13701687 2451646..2451735 1 NC_018658.1 hypothetical protein 2451735 13701687 O3K_11940 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779079.1 2451646 D 1133852 CDS YP_006779080.1 407481931 13701688 2451901..2453070 1 NC_018658.1 COG2814 Arabinose efflux permease; transporter 2453070 13701688 O3K_11945 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006779080.1 2451901 D 1133852 CDS YP_006779081.1 407481932 13701689 complement(2453216..2453797) 1 NC_018658.1 COG0605 Superoxide dismutase; superoxide dismutase 2453797 13701689 O3K_11950 Escherichia coli O104:H4 str. 2011C-3493 superoxide dismutase YP_006779081.1 2453216 R 1133852 CDS YP_006779082.1 407481933 13701690 complement(2453925..2454740) 1 NC_018658.1 COG0791 Cell wall-associated hydrolases (invasion-associated proteins); lipoprotein 2454740 13701690 O3K_11955 Escherichia coli O104:H4 str. 2011C-3493 lipoprotein YP_006779082.1 2453925 R 1133852 CDS YP_006779083.1 407481934 13701691 2455074..2455421 1 NC_018658.1 COG0278 Glutaredoxin-related protein; glutaredoxin-4 2455421 13701691 O3K_11960 Escherichia coli O104:H4 str. 2011C-3493 glutaredoxin-4 YP_006779083.1 2455074 D 1133852 CDS YP_006779084.1 407481935 13701692 complement(2455472..2460088) 1 NC_018658.1 COG1201 Lhr-like helicases; putative ATP-dependent helicase Lhr 2460088 13701692 O3K_11965 Escherichia coli O104:H4 str. 2011C-3493 putative ATP-dependent helicase Lhr YP_006779084.1 2455472 R 1133852 CDS YP_006779085.1 407481936 13701693 complement(2460181..2460828) 1 NC_018658.1 COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases; ribonuclease T 2460828 13701693 O3K_11970 Escherichia coli O104:H4 str. 2011C-3493 ribonuclease T YP_006779085.1 2460181 R 1133852 CDS YP_006779086.1 407481937 13701694 complement(2460931..2461338) 1 NC_018658.1 COG0346 Lactoylglutathione lyase and related lyases; glyoxalase I 2461338 13701694 O3K_11975 Escherichia coli O104:H4 str. 2011C-3493 glyoxalase I YP_006779086.1 2460931 R 1133852 CDS YP_006779087.1 407481938 13701695 complement(2461419..2462516) 1 NC_018658.1 COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family; N-ethylmaleimide reductase 2462516 13701695 O3K_11980 Escherichia coli O104:H4 str. 2011C-3493 N-ethylmaleimide reductase YP_006779087.1 2461419 R 1133852 CDS YP_006779088.1 407481939 13701696 complement(2462553..2463152) 1 NC_018658.1 COG1309 Transcriptional regulator; putative DNA-binding transcriptional regulator 2463152 13701696 O3K_11985 Escherichia coli O104:H4 str. 2011C-3493 putative DNA-binding transcriptional regulator YP_006779088.1 2462553 R 1133852 CDS YP_006779089.1 407481940 13701697 2463255..2463494 1 NC_018658.1 COG3313 Predicted Fe-S protein; hypothetical protein 2463494 13701697 O3K_11990 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779089.1 2463255 D 1133852 CDS YP_006779090.1 407481941 13701698 2463543..2464439 1 NC_018658.1 COG4989 Predicted oxidoreductase; oxidoreductase 2464439 13701698 O3K_11995 Escherichia coli O104:H4 str. 2011C-3493 oxidoreductase YP_006779090.1 2463543 D 1133852 CDS YP_006779091.1 407481942 13701699 2464520..2465041 1 NC_018658.1 COG2032 Cu/Zn superoxide dismutase; superoxide dismutase 2465041 13701699 O3K_12000 Escherichia coli O104:H4 str. 2011C-3493 superoxide dismutase YP_006779091.1 2464520 D 1133852 CDS YP_006779092.1 407481943 13701700 complement(2465042..2467054) 1 NC_018658.1 COG1289 Predicted membrane protein; hypothetical protein 2467054 13701700 O3K_12005 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779092.1 2465042 R 1133852 CDS YP_006779093.1 407481944 13701701 complement(2467054..2467911) 1 NC_018658.1 COG1566 Multidrug resistance efflux pump; undecaprenyl pyrophosphate phosphatase 2467911 13701701 O3K_12010 Escherichia coli O104:H4 str. 2011C-3493 undecaprenyl pyrophosphate phosphatase YP_006779093.1 2467054 R 1133852 CDS YP_006779094.1 407481945 13701702 complement(2467914..2468150) 1 NC_018658.1 hypothetical protein 2468150 13701702 O3K_12015 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779094.1 2467914 R 1133852 CDS YP_006779095.1 407481946 13701703 2468351..2468785 1 NC_018658.1 COG1846 Transcriptional regulators; transcriptional regulator SlyA 2468785 13701703 O3K_12020 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator SlyA YP_006779095.1 2468351 D 1133852 CDS YP_006779096.1 407481947 13701704 complement(2468832..2469299) 1 NC_018658.1 COG3133 Outer membrane lipoprotein; outer membrane lipoprotein SlyB 2469299 13701704 O3K_12025 Escherichia coli O104:H4 str. 2011C-3493 outer membrane lipoprotein SlyB YP_006779096.1 2468832 R 1133852 CDS YP_006779097.1 407481948 13701705 2469573..2470682 1 NC_018658.1 COG2377 Predicted molecular chaperone distantly related to HSP70-fold metalloproteases; anhydro-N-acetylmuramic acid kinase 2470682 anmK 13701705 anmK Escherichia coli O104:H4 str. 2011C-3493 anhydro-N-acetylmuramic acid kinase YP_006779097.1 2469573 D 1133852 CDS YP_006779098.1 407481949 13701706 2470780..2471109 1 NC_018658.1 COG3895 Predicted periplasmic protein; lysozyme inhibitor 2471109 13701706 O3K_12035 Escherichia coli O104:H4 str. 2011C-3493 lysozyme inhibitor YP_006779098.1 2470780 D 1133852 CDS YP_006779099.1 407481950 13701707 2471168..2471824 1 NC_018658.1 COG0259 Pyridoxamine-phosphate oxidase; pyridoxamine 5'-phosphate oxidase 2471824 13701707 O3K_12040 Escherichia coli O104:H4 str. 2011C-3493 pyridoxamine 5'-phosphate oxidase YP_006779099.1 2471168 D 1133852 CDS YP_006779100.1 407481951 13701708 2471953..2473227 1 NC_018658.1 COG0162 Tyrosyl-tRNA synthetase; tyrosyl-tRNA synthetase 2473227 13701708 O3K_12045 Escherichia coli O104:H4 str. 2011C-3493 tyrosyl-tRNA synthetase YP_006779100.1 2471953 D 1133852 CDS YP_006779101.1 407481952 13701709 2473289..2474149 1 NC_018658.1 COG2240 Pyridoxal/pyridoxine/pyridoxamine kinase; pyridoxamine kinase 2474149 13701709 O3K_12050 Escherichia coli O104:H4 str. 2011C-3493 pyridoxamine kinase YP_006779101.1 2473289 D 1133852 CDS YP_006779102.1 407481953 13701710 complement(2474193..2474798) 1 NC_018658.1 COG0625 Glutathione S-transferase; glutathionine S-transferase 2474798 13701710 O3K_12055 Escherichia coli O104:H4 str. 2011C-3493 glutathionine S-transferase YP_006779102.1 2474193 R 1133852 CDS YP_006779103.1 407481954 13701711 complement(2474904..2476406) 1 NC_018658.1 COG3104 Dipeptide/tripeptide permease; putative tripeptide transporter permease 2476406 tppB 13701711 tppB Escherichia coli O104:H4 str. 2011C-3493 putative tripeptide transporter permease YP_006779103.1 2474904 R 1133852 CDS YP_006779104.1 407481955 13701712 complement(2476689..2476889) 1 NC_018658.1 hypothetical protein 2476889 13701712 O3K_12065 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779104.1 2476689 R 1133852 CDS YP_006779105.1 407481956 13701713 complement(2477017..2477652) 1 NC_018658.1 COG0177 Predicted EndoIII-related endonuclease; endonuclease III 2477652 13701713 O3K_12070 Escherichia coli O104:H4 str. 2011C-3493 endonuclease III YP_006779105.1 2477017 R 1133852 CDS YP_006779106.1 407481957 13701714 complement(2477652..2478347) 1 NC_018658.1 COG4660 Predicted NADH:ubiquinone oxidoreductase, subunit RnfE; electron transport complex protein RsxE 2478347 13701714 O3K_12075 Escherichia coli O104:H4 str. 2011C-3493 electron transport complex protein RsxE YP_006779106.1 2477652 R 1133852 CDS YP_006779107.1 407481958 13701715 complement(2478351..2478971) 1 NC_018658.1 COG4659 Predicted NADH:ubiquinone oxidoreductase, subunit RnfG; electron transport complex protein RnfG 2478971 13701715 O3K_12080 Escherichia coli O104:H4 str. 2011C-3493 electron transport complex protein RnfG YP_006779107.1 2478351 R 1133852 CDS YP_006779108.1 407481959 13701716 complement(2478975..2480033) 1 NC_018658.1 COG4658 Predicted NADH:ubiquinone oxidoreductase, subunit RnfD; electron transport complex protein RnfD 2480033 rnfD 13701716 rnfD Escherichia coli O104:H4 str. 2011C-3493 electron transport complex protein RnfD YP_006779108.1 2478975 R 1133852 CDS YP_006779109.1 407481960 13701787 complement(2480034..2482064) 1 NC_018658.1 COG4656 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC; electron transport complex protein RnfC 2482064 13701787 O3K_12090 Escherichia coli O104:H4 str. 2011C-3493 electron transport complex protein RnfC YP_006779109.1 2480034 R 1133852 CDS YP_006779110.1 407481961 13701788 complement(2482057..2482635) 1 NC_018658.1 COG2878 Predicted NADH:ubiquinone oxidoreductase, subunit RnfB; electron transport complex protein RnfB 2482635 13701788 O3K_12095 Escherichia coli O104:H4 str. 2011C-3493 electron transport complex protein RnfB YP_006779110.1 2482057 R 1133852 CDS YP_006779111.1 407481962 13701789 complement(2482635..2483216) 1 NC_018658.1 COG4657 Predicted NADH:ubiquinone oxidoreductase, subunit RnfA; electron transport complex protein RsxA 2483216 13701789 O3K_12100 Escherichia coli O104:H4 str. 2011C-3493 electron transport complex protein RsxA YP_006779111.1 2482635 R 1133852 CDS YP_006779112.1 407481963 13701790 complement(2483293..2483733) 1 NC_018658.1 hypothetical protein 2483733 13701790 O3K_12105 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779112.1 2483293 R 1133852 CDS YP_006779113.1 407481964 13701791 complement(2483819..2484034) 1 NC_018658.1 oriC-binding nucleoid-associated protein 2484034 13701791 O3K_12110 Escherichia coli O104:H4 str. 2011C-3493 oriC-binding nucleoid-associated protein YP_006779113.1 2483819 R 1133852 CDS YP_006779114.1 407481965 13701792 2484675..2485715 1 NC_018658.1 COG0673 Predicted dehydrogenases and related proteins; oxidoreductase 2485715 13701792 O3K_12115 Escherichia coli O104:H4 str. 2011C-3493 oxidoreductase YP_006779114.1 2484675 D 1133852 CDS YP_006779115.1 407481966 13701793 complement(2485750..2486751) 1 NC_018658.1 COG1816 Adenosine deaminase; adenosine deaminase 2486751 13701793 O3K_12120 Escherichia coli O104:H4 str. 2011C-3493 adenosine deaminase YP_006779115.1 2485750 R 1133852 CDS YP_006779116.1 407481967 13701794 complement(2486855..2488027) 1 NC_018658.1 COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities; bifunctional beta-cystathionase and regulator of maltose regulon 2488027 13701794 O3K_12125 Escherichia coli O104:H4 str. 2011C-3493 bifunctional beta-cystathionase and regulator of maltose regulon YP_006779116.1 2486855 R 1133852 CDS YP_006779117.1 407481968 13701795 complement(2488037..2489629) 1 NC_018658.1 COG1263 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific; PTS system maltose and glucose-specific transporter subunits IICB 2489629 13701795 O3K_12130 Escherichia coli O104:H4 str. 2011C-3493 PTS system maltose and glucose-specific transporter subunits IICB YP_006779117.1 2488037 R 1133852 CDS YP_006779118.1 407481969 13701796 2489804..2490832 1 NC_018658.1 COG1609 Transcriptional regulators; DNA-binding transcriptional repressor MalI 2490832 13701796 O3K_12135 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional repressor MalI YP_006779118.1 2489804 D 1133852 CDS YP_006779119.1 407481970 13701797 2490944..2491711 1 NC_018658.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); 7-alpha-hydroxysteroid dehydrogenase 2491711 13701797 O3K_12140 Escherichia coli O104:H4 str. 2011C-3493 7-alpha-hydroxysteroid dehydrogenase YP_006779119.1 2490944 D 1133852 CDS YP_006779120.1 407481971 13701798 2491940..2492530 1 NC_018658.1 COG1309 Transcriptional regulator; DNA-binding transcriptional repressor UidR 2492530 13701798 O3K_12145 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional repressor UidR YP_006779120.1 2491940 D 1133852 CDS YP_006779121.1 407481972 13701799 2492919..2494730 1 NC_018658.1 COG3250 Beta-galactosidase/beta-glucuronidase; beta-D-glucuronidase 2494730 13701799 O3K_12150 Escherichia coli O104:H4 str. 2011C-3493 beta-D-glucuronidase YP_006779121.1 2492919 D 1133852 CDS YP_006779122.1 407481973 13701800 2494727..2496100 1 NC_018658.1 COG2211 Na+/melibiose symporter and related transporters; glucuronide transporter 2496100 13701800 O3K_12155 Escherichia coli O104:H4 str. 2011C-3493 glucuronide transporter YP_006779122.1 2494727 D 1133852 CDS YP_006779123.1 407481974 13701801 2496139..2497404 1 NC_018658.1 putative outer membrane porin protein 2497404 13701801 O3K_12160 Escherichia coli O104:H4 str. 2011C-3493 putative outer membrane porin protein YP_006779123.1 2496139 D 1133852 CDS YP_006779124.1 407481975 13701802 complement(2497449..2498957) 1 NC_018658.1 COG5339 Uncharacterized protein conserved in bacteria; hypothetical protein 2498957 13701802 O3K_12165 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779124.1 2497449 R 1133852 CDS YP_006779125.1 407481976 13701803 complement(2499058..2500233) 1 NC_018658.1 COG1482 Phosphomannose isomerase; mannose-6-phosphate isomerase 2500233 13701803 O3K_12170 Escherichia coli O104:H4 str. 2011C-3493 mannose-6-phosphate isomerase YP_006779125.1 2499058 R 1133852 CDS YP_006779126.1 407481977 13701804 2500432..2502078 1 NC_018658.1 COG1951 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain; fumarate hydratase FumA 2502078 13701804 O3K_12175 Escherichia coli O104:H4 str. 2011C-3493 fumarate hydratase FumA YP_006779126.1 2500432 D 1133852 CDS YP_006779127.1 407481978 13701805 2502221..2503624 1 NC_018658.1 COG0114 Fumarase; fumarate hydratase 2503624 fumC 13701805 fumC Escherichia coli O104:H4 str. 2011C-3493 fumarate hydratase YP_006779127.1 2502221 D 1133852 CDS YP_006779128.1 407481979 13701806 complement(2503621..2504550) 1 NC_018658.1 DNA replication terminus site-binding protein 2504550 13701806 O3K_12185 Escherichia coli O104:H4 str. 2011C-3493 DNA replication terminus site-binding protein YP_006779128.1 2503621 R 1133852 CDS YP_006779129.1 407481980 13701807 complement(2504626..2505927) 1 NC_018658.1 COG0642 Signal transduction histidine kinase; sensor protein RstB 2505927 13701807 O3K_12190 Escherichia coli O104:H4 str. 2011C-3493 sensor protein RstB YP_006779129.1 2504626 R 1133852 CDS YP_006779130.1 407481981 13701808 complement(2505931..2506650) 1 NC_018658.1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; DNA-binding transcriptional regulator RstA 2506650 13701808 O3K_12195 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator RstA YP_006779130.1 2505931 R 1133852 CDS YP_006779131.1 407481982 13701809 2506779..2507114 1 NC_018658.1 COG3136 Uncharacterized membrane protein required for alginate biosynthesis; GlpM family protein 2507114 13701809 O3K_12200 Escherichia coli O104:H4 str. 2011C-3493 GlpM family protein YP_006779131.1 2506779 D 1133852 CDS YP_006779132.1 407481983 13701810 complement(2507111..2507833) 1 NC_018658.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); dihydromonapterin reductase 2507833 13701810 O3K_12205 Escherichia coli O104:H4 str. 2011C-3493 dihydromonapterin reductase YP_006779132.1 2507111 R 1133852 CDS YP_006779133.1 407481984 13701811 complement(2507870..2509252) 1 NC_018658.1 COG0531 Amino acid transporters; putative arginine/ornithine antiporter 2509252 13701811 O3K_12210 Escherichia coli O104:H4 str. 2011C-3493 putative arginine/ornithine antiporter YP_006779133.1 2507870 R 1133852 CDS YP_006779134.1 407481985 13701812 complement(2509438..2510382) 1 NC_018658.1 hypothetical protein 2510382 13701812 O3K_12215 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779134.1 2509438 R 1133852 CDS YP_006779135.1 407481986 13701813 2510907..2512439 1 NC_018658.1 COG3288 NAD/NADP transhydrogenase alpha subunit; NAD(P) transhydrogenase subunit alpha 2512439 pntA 13701813 pntA Escherichia coli O104:H4 str. 2011C-3493 NAD(P) transhydrogenase subunit alpha YP_006779135.1 2510907 D 1133852 CDS YP_006779136.1 407481987 13701814 2512450..2513838 1 NC_018658.1 COG1282 NAD/NADP transhydrogenase beta subunit; pyridine nucleotide transhydrogenase 2513838 pntB 13701814 pntB Escherichia coli O104:H4 str. 2011C-3493 pyridine nucleotide transhydrogenase YP_006779136.1 2512450 D 1133852 CDS YP_006779137.1 407481988 13701815 complement(2513863..2514897) 1 NC_018658.1 COG0628 Predicted permease; pheromone autoinducer 2 transporter 2514897 tqsA 13701815 tqsA Escherichia coli O104:H4 str. 2011C-3493 pheromone autoinducer 2 transporter YP_006779137.1 2513863 R 1133852 CDS YP_006779138.1 407481989 13701816 2515309..2515674 1 NC_018658.1 COG2076 Membrane transporters of cations and cationic drugs; multidrug efflux system protein MdtJ 2515674 13701816 O3K_12235 Escherichia coli O104:H4 str. 2011C-3493 multidrug efflux system protein MdtJ YP_006779138.1 2515309 D 1133852 CDS YP_006779139.1 407481990 13701817 2515661..2515990 1 NC_018658.1 COG2076 Membrane transporters of cations and cationic drugs; multidrug efflux system protein MdtI 2515990 13701817 O3K_12240 Escherichia coli O104:H4 str. 2011C-3493 multidrug efflux system protein MdtI YP_006779139.1 2515661 D 1133852 CDS YP_006779140.1 407481991 13701818 complement(2516029..2516850) 1 NC_018658.1 COG3591 V8-like Glu-specific endopeptidase; metallopeptidase 2516850 13701818 O3K_12245 Escherichia coli O104:H4 str. 2011C-3493 metallopeptidase YP_006779140.1 2516029 R 1133852 CDS YP_006779141.1 407481992 13701819 complement(2516950..2517033) 1 NC_018658.1 hypothetical protein 2517033 13701819 O3K_12250 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779141.1 2516950 R 1133852 CDS YP_006779142.1 407481993 13701820 complement(2517126..2517434) 1 NC_018658.1 acid shock protein 2517434 13701820 O3K_12255 Escherichia coli O104:H4 str. 2011C-3493 acid shock protein YP_006779142.1 2517126 R 1133852 CDS YP_006779143.1 407481994 13701821 complement(2517858..2519111) 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; transporter, MFS type 2519111 13701821 O3K_12260 Escherichia coli O104:H4 str. 2011C-3493 transporter, MFS type YP_006779143.1 2517858 R 1133852 CDS YP_006779144.1 407481995 13701822 2519218..2520111 1 NC_018658.1 COG0583 Transcriptional regulator; DNA-binding transcriptional regulator 2520111 13701822 O3K_12265 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator YP_006779144.1 2519218 D 1133852 CDS YP_006779145.1 407481996 13701823 2520246..2521466 1 NC_018658.1 COG1940 Transcriptional regulator/sugar kinase; NAGC-like transcriptional regulator 2521466 13701823 O3K_12270 Escherichia coli O104:H4 str. 2011C-3493 NAGC-like transcriptional regulator YP_006779145.1 2520246 D 1133852 CDS YP_006779146.1 407481997 13701824 2521591..2522286 1 NC_018658.1 COG0132 Dethiobiotin synthetase; putative dithiobiotin synthetase 2522286 13701824 O3K_12275 Escherichia coli O104:H4 str. 2011C-3493 putative dithiobiotin synthetase YP_006779146.1 2521591 D 1133852 CDS YP_006779147.1 407481998 13701825 complement(2522302..2523495) 1 NC_018658.1 COG0038 Chloride channel protein EriC; putative voltage-gated ClC-type chloride channel ClcB 2523495 13701825 O3K_12280 Escherichia coli O104:H4 str. 2011C-3493 putative voltage-gated ClC-type chloride channel ClcB YP_006779147.1 2522302 R 1133852 CDS YP_006779148.1 407481999 13701826 complement(2523690..2524304) 1 NC_018658.1 COG3381 Uncharacterized component of anaerobic dehydrogenases; twin-argninine leader-binding protein DmsD 2524304 13701826 O3K_12285 Escherichia coli O104:H4 str. 2011C-3493 twin-argninine leader-binding protein DmsD YP_006779148.1 2523690 R 1133852 CDS YP_006779149.1 407482000 13701827 complement(2524347..2525201) 1 NC_018658.1 COG3302 DMSO reductase anchor subunit; oxidoreductase, membrane subunit 2525201 13701827 O3K_12290 Escherichia coli O104:H4 str. 2011C-3493 oxidoreductase, membrane subunit YP_006779149.1 2524347 R 1133852 CDS YP_006779150.1 407482001 13701828 complement(2525203..2525754) 1 NC_018658.1 COG0437 Fe-S-cluster-containing hydrogenase components 1; anaerobic dimethyl sulfoxide reductase chain ynfG 2525754 13701828 O3K_12295 Escherichia coli O104:H4 str. 2011C-3493 anaerobic dimethyl sulfoxide reductase chain ynfG YP_006779150.1 2525203 R 1133852 CDS YP_006779151.1 407482002 13701829 complement(2525795..2526958) 1 NC_018658.1 COG0582 Integrase; prophage DLP12 integrase 2526958 13701829 O3K_12300 Escherichia coli O104:H4 str. 2011C-3493 prophage DLP12 integrase YP_006779151.1 2525795 R 1133852 CDS YP_006779152.1 407482003 13701830 complement(2526814..2527185) 1 NC_018658.1 COG2452 Predicted site-specific integrase-resolvase; Excisionase 2527185 13701830 O3K_12305 Escherichia coli O104:H4 str. 2011C-3493 Excisionase YP_006779152.1 2526814 R 1133852 CDS YP_006779153.1 407482004 13701831 complement(2527220..2527471) 1 NC_018658.1 hypothetical protein 2527471 13701831 O3K_12310 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779153.1 2527220 R 1133852 CDS YP_006779154.1 407482005 13701832 complement(2527519..2528199) 1 NC_018658.1 Exonuclease 2528199 13701832 O3K_12315 Escherichia coli O104:H4 str. 2011C-3493 Exonuclease YP_006779154.1 2527519 R 1133852 CDS YP_006779155.1 407482006 13701833 complement(2528196..2528981) 1 NC_018658.1 COG0488 ATPase components of ABC transporters with duplicated ATPase domains; Recombination protein bet from phage origin 2528981 13701833 O3K_12320 Escherichia coli O104:H4 str. 2011C-3493 Recombination protein bet from phage origin YP_006779155.1 2528196 R 1133852 CDS YP_006779156.1 407482007 13701834 complement(2528987..2529283) 1 NC_018658.1 putative host-nuclease inhibitor protein Gam of bacteriophage 2529283 13701834 O3K_12325 Escherichia coli O104:H4 str. 2011C-3493 putative host-nuclease inhibitor protein Gam of bacteriophage YP_006779156.1 2528987 R 1133852 CDS YP_006779157.1 407482008 13701835 complement(2531460..2531846) 1 NC_018658.1 hypothetical protein 2531846 13701835 O3K_12335 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779157.1 2531460 R 1133852 CDS YP_006779158.1 407482009 13701836 complement(2531930..2532151) 1 NC_018658.1 FtsZ inhibitor protein 2532151 kil 13701836 kil Escherichia coli O104:H4 str. 2011C-3493 FtsZ inhibitor protein YP_006779158.1 2531930 R 1133852 CDS YP_006779159.1 407482010 13701837 2532608..2532817 1 NC_018658.1 hypothetical protein 2532817 13701837 O3K_12345 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779159.1 2532608 D 1133852 CDS YP_006779160.1 407482011 13701838 2532921..2533151 1 NC_018658.1 hypothetical protein 2533151 13701838 O3K_12350 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779160.1 2532921 D 1133852 CDS YP_006779161.1 407482012 13701839 complement(2533177..2533890) 1 NC_018658.1 hypothetical protein 2533890 13701839 O3K_12355 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779161.1 2533177 R 1133852 CDS YP_006779162.1 407482013 13701840 complement(2533894..2534277) 1 NC_018658.1 Antitermination protein N 2534277 13701840 O3K_12360 Escherichia coli O104:H4 str. 2011C-3493 Antitermination protein N YP_006779162.1 2533894 R 1133852 CDS YP_006779163.1 407482014 13701841 complement(2534772..2535548) 1 NC_018658.1 hypothetical protein 2535548 13701841 O3K_12365 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779163.1 2534772 R 1133852 CDS YP_006779164.1 407482015 13701842 complement(2535536..2536078) 1 NC_018658.1 hypothetical protein 2536078 13701842 O3K_12370 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779164.1 2535536 R 1133852 CDS YP_006779165.1 407482016 13701843 complement(2536125..2536838) 1 NC_018658.1 COG1974 SOS-response transcriptional repressors (RecA-mediated autopeptidases); Repressor protein CI from prophage 2536838 13701843 O3K_12375 Escherichia coli O104:H4 str. 2011C-3493 Repressor protein CI from prophage YP_006779165.1 2536125 R 1133852 CDS YP_006779166.1 407482017 13701844 2536939..2537139 1 NC_018658.1 regulatory protein cro 2537139 13701844 O3K_12380 Escherichia coli O104:H4 str. 2011C-3493 regulatory protein cro YP_006779166.1 2536939 D 1133852 CDS YP_006779167.1 407482018 13701845 2537278..2537574 1 NC_018658.1 regulatory protein CII from prophage 2537574 13701845 O3K_12385 Escherichia coli O104:H4 str. 2011C-3493 regulatory protein CII from prophage YP_006779167.1 2537278 D 1133852 CDS YP_006779168.1 407482019 13701846 2537589..2537807 1 NC_018658.1 hypothetical protein 2537807 13701846 O3K_12390 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779168.1 2537589 D 1133852 CDS YP_006779169.1 407482020 13701847 2537909..2538910 1 NC_018658.1 hypothetical protein 2538910 13701847 O3K_12395 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779169.1 2537909 D 1133852 CDS YP_006779170.1 407482021 13701848 2538917..2539657 1 NC_018658.1 COG1484 DNA replication protein; putative replication protein 2539657 13701848 O3K_12400 Escherichia coli O104:H4 str. 2011C-3493 putative replication protein YP_006779170.1 2538917 D 1133852 CDS YP_006779171.1 407482022 13701849 2539683..2540453 1 NC_018658.1 COG1349 Transcriptional regulators of sugar metabolism; hypothetical protein 2540453 13701849 O3K_12405 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779171.1 2539683 D 1133852 CDS YP_006779172.1 407482023 13701850 2540469..2540864 1 NC_018658.1 hypothetical protein 2540864 13701850 O3K_12410 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779172.1 2540469 D 1133852 CDS YP_006779173.1 407482024 13701851 2540921..2541505 1 NC_018658.1 hypothetical protein 2541505 13701851 O3K_12415 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779173.1 2540921 D 1133852 CDS YP_006779174.1 407482025 13701852 2541621..2541725 1 NC_018658.1 hypothetical protein 2541725 13701852 O3K_12420 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779174.1 2541621 D 1133852 CDS YP_006779175.1 407482026 13701853 2541914..2542126 1 NC_018658.1 cell killing protein encoded within cryptic prophage CP-933P 2542126 13701853 O3K_12425 Escherichia coli O104:H4 str. 2011C-3493 cell killing protein encoded within cryptic prophage CP-933P YP_006779175.1 2541914 D 1133852 CDS YP_006779176.1 407482027 13701854 2542336..2542515 1 NC_018658.1 bacteriophage protein 2542515 13701854 O3K_12430 Escherichia coli O104:H4 str. 2011C-3493 bacteriophage protein YP_006779176.1 2542336 D 1133852 CDS YP_006779177.1 407482028 13701855 2542534..2543019 1 NC_018658.1 COG3654 Prophage maintenance system killer protein; bacteriophage protein 2543019 13701855 O3K_12435 Escherichia coli O104:H4 str. 2011C-3493 bacteriophage protein YP_006779177.1 2542534 D 1133852 CDS YP_006779178.1 407482029 13701856 complement(2543070..2543387) 1 NC_018658.1 COG2944 Predicted transcriptional regulator; DNA-binding protein 2543387 13701856 O3K_12440 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding protein YP_006779178.1 2543070 R 1133852 CDS YP_006779179.1 407482030 13701857 complement(2543495..2543749) 1 NC_018658.1 COG4737 Uncharacterized protein conserved in bacteria; hypothetical protein 2543749 13701857 O3K_12445 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779179.1 2543495 R 1133852 CDS YP_006779180.1 407482031 13701858 2544094..2544765 1 NC_018658.1 putative antirepressor protein Ant from prophage 2544765 13701858 O3K_12450 Escherichia coli O104:H4 str. 2011C-3493 putative antirepressor protein Ant from prophage YP_006779180.1 2544094 D 1133852 CDS YP_006779181.1 407482032 13701859 2544820..2545230 1 NC_018658.1 putative ninB protein 2545230 13701859 O3K_12455 Escherichia coli O104:H4 str. 2011C-3493 putative ninB protein YP_006779181.1 2544820 D 1133852 CDS YP_006779182.1 407482033 13701860 2545227..2545418 1 NC_018658.1 NinE protein 2545418 13701860 O3K_12460 Escherichia coli O104:H4 str. 2011C-3493 NinE protein YP_006779182.1 2545227 D 1133852 CDS YP_006779183.1 407482034 13701861 2545442..2545732 1 NC_018658.1 hypothetical protein 2545732 13701861 O3K_12465 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779183.1 2545442 D 1133852 CDS YP_006779184.1 407482035 13701862 2545729..2546091 1 NC_018658.1 COG4570 Holliday junction resolvase; crossover junction endodeoxyribonuclease 2546091 13701862 O3K_12470 Escherichia coli O104:H4 str. 2011C-3493 crossover junction endodeoxyribonuclease YP_006779184.1 2545729 D 1133852 CDS YP_006779185.1 407482036 13701863 2546091..2546285 1 NC_018658.1 Protein ninH from prophage 2546285 13701863 O3K_12475 Escherichia coli O104:H4 str. 2011C-3493 Protein ninH from prophage YP_006779185.1 2546091 D 1133852 CDS YP_006779186.1 407482037 13701864 2546278..2546712 1 NC_018658.1 antitermination protein Q 2546712 13701864 O3K_12480 Escherichia coli O104:H4 str. 2011C-3493 antitermination protein Q YP_006779186.1 2546278 D 1133852 CDS YP_006779187.1 407482038 13701865 2547478..2549388 1 NC_018658.1 hypothetical protein 2549388 13701865 O3K_12485 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779187.1 2547478 D 1133852 CDS YP_006779188.1 407482039 13701866 2549527..2549709 1 NC_018658.1 hypothetical protein 2549709 13701866 O3K_12490 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779188.1 2549527 D 1133852 CDS YP_006779189.1 407482040 13701867 2549735..2549980 1 NC_018658.1 hypothetical protein 2549980 13701867 O3K_12495 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779189.1 2549735 D 1133852 CDS YP_006779190.1 407482041 13701938 2550057..2550272 1 NC_018658.1 lysis protein S of prophage CP-933V 2550272 13701938 O3K_12500 Escherichia coli O104:H4 str. 2011C-3493 lysis protein S of prophage CP-933V YP_006779190.1 2550057 D 1133852 CDS YP_006779191.1 407482042 13701939 2550277..2550810 1 NC_018658.1 COG3772 Phage-related lysozyme (muraminidase); endolysin 2550810 13701939 O3K_12505 Escherichia coli O104:H4 str. 2011C-3493 endolysin YP_006779191.1 2550277 D 1133852 CDS YP_006779192.1 407482043 13701940 2551031..2551144 1 NC_018658.1 hypothetical protein 2551144 13701940 O3K_12510 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779192.1 2551031 D 1133852 CDS YP_006779193.1 407482044 13701941 2551146..2551604 1 NC_018658.1 endopeptidase 2551604 13701941 O3K_12515 Escherichia coli O104:H4 str. 2011C-3493 endopeptidase YP_006779193.1 2551146 D 1133852 CDS YP_006779194.1 407482045 13701942 complement(2551685..2552266) 1 NC_018658.1 lipopolysaccharide core heptose(II)-phosphate phosphatase 2552266 13701942 O3K_12520 Escherichia coli O104:H4 str. 2011C-3493 lipopolysaccharide core heptose(II)-phosphate phosphatase YP_006779194.1 2551685 R 1133852 CDS YP_006779195.1 407482046 13701943 2552869..2553684 1 NC_018658.1 small subunit terminase 2553684 13701943 O3K_12525 Escherichia coli O104:H4 str. 2011C-3493 small subunit terminase YP_006779195.1 2552869 D 1133852 CDS YP_006779196.1 407482047 13701944 2553665..2555371 1 NC_018658.1 putative large subunit terminase 2555371 13701944 O3K_12530 Escherichia coli O104:H4 str. 2011C-3493 putative large subunit terminase YP_006779196.1 2553665 D 1133852 CDS YP_006779197.1 407482048 13701945 2555371..2557515 1 NC_018658.1 putative portal protein 2557515 13701945 O3K_12535 Escherichia coli O104:H4 str. 2011C-3493 putative portal protein YP_006779197.1 2555371 D 1133852 CDS YP_006779198.1 407482049 13701946 2557673..2558680 1 NC_018658.1 COG0061 Predicted sugar kinase; hypothetical protein 2558680 13701946 O3K_12540 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779198.1 2557673 D 1133852 CDS YP_006779199.1 407482050 13701947 2558703..2559917 1 NC_018658.1 hypothetical protein 2559917 13701947 O3K_12545 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779199.1 2558703 D 1133852 CDS YP_006779200.1 407482051 13701948 2559972..2560361 1 NC_018658.1 hypothetical protein 2560361 13701948 O3K_12550 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779200.1 2559972 D 1133852 CDS YP_006779201.1 407482052 13701949 2560412..2560873 1 NC_018658.1 hypothetical protein 2560873 13701949 O3K_12555 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779201.1 2560412 D 1133852 CDS YP_006779202.1 407482053 13701950 2560857..2561420 1 NC_018658.1 hypothetical protein 2561420 13701950 O3K_12560 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779202.1 2560857 D 1133852 CDS YP_006779203.1 407482054 13701951 2561420..2562070 1 NC_018658.1 hypothetical protein 2562070 13701951 O3K_12565 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779203.1 2561420 D 1133852 CDS YP_006779204.1 407482055 13701952 2562067..2563974 1 NC_018658.1 putative tail fiber protein 2563974 13701952 O3K_12570 Escherichia coli O104:H4 str. 2011C-3493 putative tail fiber protein YP_006779204.1 2562067 D 1133852 CDS YP_006779205.1 407482056 13701953 2564615..2564842 1 NC_018658.1 COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II; hypothetical protein 2564842 13701953 O3K_12575 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779205.1 2564615 D 1133852 CDS YP_006779206.1 407482057 13701954 2565183..2566808 1 NC_018658.1 hypothetical protein 2566808 13701954 O3K_12580 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779206.1 2565183 D 1133852 CDS YP_006779207.1 407482058 13701955 2566805..2568073 1 NC_018658.1 COG4733 Phage-related protein, tail component; putative tail tip fiber protein 2568073 13701955 O3K_12585 Escherichia coli O104:H4 str. 2011C-3493 putative tail tip fiber protein YP_006779207.1 2566805 D 1133852 CDS YP_006779208.1 407482059 13701956 2568088..2568366 1 NC_018658.1 outer membrane protein 2568366 13701956 O3K_12590 Escherichia coli O104:H4 str. 2011C-3493 outer membrane protein YP_006779208.1 2568088 D 1133852 CDS YP_006779209.1 407482060 13701957 2568372..2568989 1 NC_018658.1 hypothetical protein 2568989 13701957 O3K_12595 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779209.1 2568372 D 1133852 CDS YP_006779210.1 407482061 13701958 2569081..2569806 1 NC_018658.1 outer membrane precursor Lom 2569806 13701958 O3K_12600 Escherichia coli O104:H4 str. 2011C-3493 outer membrane precursor Lom YP_006779210.1 2569081 D 1133852 CDS YP_006779211.1 407482062 13701959 2570041..2570181 1 NC_018658.1 hypothetical protein 2570181 13701959 O3K_12605 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779211.1 2570041 D 1133852 CDS YP_006779212.1 407482063 13701960 2570238..2570639 1 NC_018658.1 hypothetical protein 2570639 13701960 O3K_12610 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779212.1 2570238 D 1133852 CDS YP_006779213.1 407482064 13701961 2570731..2571387 1 NC_018658.1 hypothetical protein 2571387 13701961 O3K_12615 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779213.1 2570731 D 1133852 CDS YP_006779214.1 407482065 13701962 2571390..2571836 1 NC_018658.1 hypothetical protein 2571836 13701962 O3K_12620 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779214.1 2571390 D 1133852 CDS YP_006779215.1 407482066 13701963 2571846..2572097 1 NC_018658.1 hypothetical protein 2572097 13701963 O3K_12625 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779215.1 2571846 D 1133852 CDS YP_006779216.1 407482067 13701964 2572108..2573373 1 NC_018658.1 hypothetical protein 2573373 13701964 O3K_12630 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779216.1 2572108 D 1133852 CDS YP_006779217.1 407482068 13701965 2573442..2581793 1 NC_018658.1 COG1080 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria); hypothetical protein 2581793 13701965 O3K_12635 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779217.1 2573442 D 1133852 CDS YP_006779218.1 407482069 13701966 2581917..2582192 1 NC_018658.1 hypothetical protein 2582192 13701966 O3K_12640 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779218.1 2581917 D 1133852 CDS YP_006779219.1 407482070 13701967 complement(2582194..2582697) 1 NC_018658.1 hypothetical protein 2582697 13701967 O3K_12645 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779219.1 2582194 R 1133852 CDS YP_006779220.1 407482071 13701968 complement(2582694..2583209) 1 NC_018658.1 hypothetical protein 2583209 13701968 O3K_12650 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779220.1 2582694 R 1133852 CDS YP_006779221.1 407482072 13701969 complement(2583211..2584047) 1 NC_018658.1 hypothetical protein 2584047 13701969 O3K_12655 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779221.1 2583211 R 1133852 CDS YP_006779222.1 407482073 13701970 complement(2584034..2584318) 1 NC_018658.1 hypothetical protein 2584318 13701970 O3K_12660 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779222.1 2584034 R 1133852 CDS YP_006779223.1 407482074 13701971 complement(2584315..2584536) 1 NC_018658.1 COG1734 DnaK suppressor protein; putative C4-type zinc finger protein 2584536 13701971 O3K_12665 Escherichia coli O104:H4 str. 2011C-3493 putative C4-type zinc finger protein YP_006779223.1 2584315 R 1133852 CDS YP_006779224.1 407482075 13701972 complement(2584584..2585219) 1 NC_018658.1 COG3561 Phage anti-repressor protein; phage anti-repressor protein AntB 2585219 13701972 O3K_12670 Escherichia coli O104:H4 str. 2011C-3493 phage anti-repressor protein AntB YP_006779224.1 2584584 R 1133852 CDS YP_006779225.1 407482076 13701973 complement(2585627..2585740) 1 NC_018658.1 COG0437 Fe-S-cluster-containing hydrogenase components 1; dimethyl sulfoxide reductase subunit B 2585740 13701973 O3K_12675 Escherichia coli O104:H4 str. 2011C-3493 dimethyl sulfoxide reductase subunit B YP_006779225.1 2585627 R 1133852 CDS YP_006779226.1 407482077 13701974 complement(2585751..2588174) 1 NC_018658.1 COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; oxidoreductase subunit 2588174 13701974 O3K_12680 Escherichia coli O104:H4 str. 2011C-3493 oxidoreductase subunit YP_006779226.1 2585751 R 1133852 CDS YP_006779227.1 407482078 13701975 complement(2588235..2590661) 1 NC_018658.1 COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; oxidoreductase subunit 2590661 13701975 O3K_12685 Escherichia coli O104:H4 str. 2011C-3493 oxidoreductase subunit YP_006779227.1 2588235 R 1133852 CDS YP_006779228.1 407482079 13701976 complement(2590860..2591165) 1 NC_018658.1 hypothetical protein 2591165 13701976 O3K_12690 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779228.1 2590860 R 1133852 CDS YP_006779229.1 407482080 13701977 2591273..2591983 1 NC_018658.1 lipoprotein 2591983 13701977 O3K_12695 Escherichia coli O104:H4 str. 2011C-3493 lipoprotein YP_006779229.1 2591273 D 1133852 CDS YP_006779230.1 407482081 13701978 complement(2591986..2592546) 1 NC_018658.1 COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins; spermidine N1-acetyltransferase 2592546 13701978 O3K_12700 Escherichia coli O104:H4 str. 2011C-3493 spermidine N1-acetyltransferase YP_006779230.1 2591986 R 1133852 CDS YP_006779231.1 407482082 13701979 complement(2592581..2592922) 1 NC_018658.1 hypothetical protein 2592922 13701979 O3K_12705 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779231.1 2592581 R 1133852 CDS YP_006779232.1 407482083 13701980 2593057..2593383 1 NC_018658.1 COG1742 Uncharacterized conserved protein; hypothetical protein 2593383 13701980 O3K_12710 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779232.1 2593057 D 1133852 CDS YP_006779233.1 407482084 13701981 2593589..2594803 1 NC_018658.1 COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily; bifunctional D-altronate/D-mannonate dehydratase 2594803 13701981 O3K_12715 Escherichia coli O104:H4 str. 2011C-3493 bifunctional D-altronate/D-mannonate dehydratase YP_006779233.1 2593589 D 1133852 CDS YP_006779234.1 407482085 13701982 2594815..2595834 1 NC_018658.1 COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases; oxidoreductase 2595834 13701982 O3K_12720 Escherichia coli O104:H4 str. 2011C-3493 oxidoreductase YP_006779234.1 2594815 D 1133852 CDS YP_006779235.1 407482086 13701983 2595976..2597259 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; transporter 2597259 13701983 O3K_12725 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006779235.1 2595976 D 1133852 CDS YP_006779236.1 407482087 13701984 2597348..2598808 1 NC_018658.1 COG0246 Mannitol-1-phosphate/altronate dehydrogenases; mannonate dehydrogenase 2598808 13701984 O3K_12730 Escherichia coli O104:H4 str. 2011C-3493 mannonate dehydrogenase YP_006779236.1 2597348 D 1133852 CDS YP_006779237.1 407482088 13701985 complement(2598844..2599047) 1 NC_018658.1 selenoprotein ydfZ 2599047 13701985 O3K_12735 Escherichia coli O104:H4 str. 2011C-3493 selenoprotein ydfZ YP_006779237.1 2598844 R 1133852 CDS YP_006779238.1 407482089 13701986 complement(2599225..2599911) 1 NC_018658.1 COG1802 Transcriptional regulators; hypothetical protein 2599911 13701986 O3K_12740 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779238.1 2599225 R 1133852 CDS YP_006779239.1 407482090 13701987 complement(2600000..2600746) 1 NC_018658.1 COG4221 Short-chain alcohol dehydrogenase of unknown specificity; malonic semialdehyde reductase 2600746 13701987 O3K_12745 Escherichia coli O104:H4 str. 2011C-3493 malonic semialdehyde reductase YP_006779239.1 2600000 R 1133852 CDS YP_006779240.1 407482091 13701988 2600883..2602928 1 NC_018658.1 COG0339 Zn-dependent oligopeptidases; dipeptidyl carboxypeptidase II 2602928 13701988 O3K_12750 Escherichia coli O104:H4 str. 2011C-3493 dipeptidyl carboxypeptidase II YP_006779240.1 2600883 D 1133852 CDS YP_006779241.1 407482092 13701989 complement(2602973..2603491) 1 NC_018658.1 COG1546 Uncharacterized protein (competence- and mitomycin-induced); hypothetical protein 2603491 13701989 O3K_12755 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779241.1 2602973 R 1133852 CDS YP_006779242.1 407482093 13701990 2603767..2604159 1 NC_018658.1 COG3111 Uncharacterized conserved protein; hypothetical protein 2604159 13701990 O3K_12760 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779242.1 2603767 D 1133852 CDS YP_006779243.1 407482094 13701991 2604414..2605304 1 NC_018658.1 COG2199 FOG: GGDEF domain; diguanylate cyclase 2605304 13701991 O3K_12765 Escherichia coli O104:H4 str. 2011C-3493 diguanylate cyclase YP_006779243.1 2604414 D 1133852 CDS YP_006779244.1 407482095 13701992 complement(2605524..2605619) 1 NC_018658.1 hypothetical protein 2605619 13701992 O3K_12770 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779244.1 2605524 R 1133852 CDS YP_006779245.1 407482096 13701993 complement(2605746..2606933) 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; transporter 2606933 13701993 O3K_12775 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006779245.1 2605746 R 1133852 CDS YP_006779246.1 407482097 13701994 2607128..2608027 1 NC_018658.1 COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; O-acetylserine/cysteine export protein 2608027 13701994 O3K_12780 Escherichia coli O104:H4 str. 2011C-3493 O-acetylserine/cysteine export protein YP_006779246.1 2607128 D 1133852 CDS YP_006779247.1 407482098 13701995 complement(2608072..2608770) 1 NC_018658.1 COG2188 Transcriptional regulators; transcriptional regulator 2608770 13701995 O3K_12785 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator YP_006779247.1 2608072 R 1133852 CDS YP_006779248.1 407482099 13701996 2608969..2609280 1 NC_018658.1 COG1440 Phosphotransferase system cellobiose-specific component IIB; PTS system cellobiose-specific transporter subunit IIB 2609280 13701996 O3K_12790 Escherichia coli O104:H4 str. 2011C-3493 PTS system cellobiose-specific transporter subunit IIB YP_006779248.1 2608969 D 1133852 CDS YP_006779249.1 407482100 13701997 2609395..2610717 1 NC_018658.1 COG1455 Phosphotransferase system cellobiose-specific component IIC; putative phosphotransferase system IIC component 2610717 13701997 O3K_12795 Escherichia coli O104:H4 str. 2011C-3493 putative phosphotransferase system IIC component YP_006779249.1 2609395 D 1133852 CDS YP_006779250.1 407482101 13701998 2610745..2611056 1 NC_018658.1 COG1447 Phosphotransferase system cellobiose-specific component IIA; PTS system cellobiose-specific transporter subunit IIA 2611056 13701998 O3K_12800 Escherichia coli O104:H4 str. 2011C-3493 PTS system cellobiose-specific transporter subunit IIA YP_006779250.1 2610745 D 1133852 CDS YP_006779251.1 407482102 13701999 2611112..2612785 1 NC_018658.1 COG0789 Predicted transcriptional regulators; carbohydrate-specific outer membrane porin 2612785 13701999 O3K_12805 Escherichia coli O104:H4 str. 2011C-3493 carbohydrate-specific outer membrane porin YP_006779251.1 2611112 D 1133852 CDS YP_006779252.1 407482103 13702000 2612810..2614249 1 NC_018658.1 COG2723 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase; 6-phospho-beta-glucosidase 2614249 celA 13702000 celA Escherichia coli O104:H4 str. 2011C-3493 6-phospho-beta-glucosidase YP_006779252.1 2612810 D 1133852 CDS YP_006779253.1 407482104 13702001 complement(2614306..2614524) 1 NC_018658.1 hypothetical protein 2614524 13702001 O3K_12815 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779253.1 2614306 R 1133852 CDS YP_006779254.1 407482105 13702002 complement(2614556..2614939) 1 NC_018658.1 COG2207 AraC-type DNA-binding domain-containing proteins; DNA-binding transcriptional activator MarA 2614939 13702002 O3K_12820 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional activator MarA YP_006779254.1 2614556 R 1133852 CDS YP_006779255.1 407482106 13702003 complement(2614959..2615393) 1 NC_018658.1 COG1846 Transcriptional regulators; DNA-binding transcriptional repressor MarR 2615393 13702003 O3K_12825 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional repressor MarR YP_006779255.1 2614959 R 1133852 CDS YP_006779256.1 407482107 13702004 2615605..2616270 1 NC_018658.1 COG2095 Multiple antibiotic transporter; inner membrane protein 2616270 13702004 O3K_12830 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006779256.1 2615605 D 1133852 CDS YP_006779257.1 407482108 13702005 complement(2616295..2617485) 1 NC_018658.1 COG2814 Arabinose efflux permease; putative arabinose transporter 2617485 13702005 O3K_12835 Escherichia coli O104:H4 str. 2011C-3493 putative arabinose transporter YP_006779257.1 2616295 R 1133852 CDS YP_006779258.1 407482109 13702006 complement(2617635..2617883) 1 NC_018658.1 hypothetical protein 2617883 13702006 O3K_12840 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779258.1 2617635 R 1133852 CDS YP_006779259.1 407482110 13702007 complement(2618290..2618748) 1 NC_018658.1 hypothetical protein 2618748 13702007 O3K_12845 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779259.1 2618290 R 1133852 CDS YP_006779260.1 407482111 13702008 complement(2618826..2619707) 1 NC_018658.1 COG0583 Transcriptional regulator; LysR family transcriptional regulator 2619707 13702008 O3K_12850 Escherichia coli O104:H4 str. 2011C-3493 LysR family transcriptional regulator YP_006779260.1 2618826 R 1133852 CDS YP_006779261.1 407482112 13702009 2619808..2621196 1 NC_018658.1 COG1012 NAD-dependent aldehyde dehydrogenases; putative succinate-semialdehyde dehydrogenase 2621196 13702009 O3K_12855 Escherichia coli O104:H4 str. 2011C-3493 putative succinate-semialdehyde dehydrogenase YP_006779261.1 2619808 D 1133852 CDS YP_006779262.1 407482113 13702010 2621260..2622186 1 NC_018658.1 COG2066 Glutaminase; glutaminase 2622186 13702010 O3K_12860 Escherichia coli O104:H4 str. 2011C-3493 glutaminase YP_006779262.1 2621260 D 1133852 CDS YP_006779263.1 407482114 13702011 2622186..2622545 1 NC_018658.1 hypothetical protein 2622545 13702011 O3K_12865 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779263.1 2622186 D 1133852 CDS YP_006779264.1 407482115 13702012 2622684..2624102 1 NC_018658.1 COG2199 FOG: GGDEF domain; hypothetical protein 2624102 13702012 O3K_12870 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779264.1 2622684 D 1133852 CDS YP_006779265.1 407482116 13702013 2624329..2625780 1 NC_018658.1 COG0246 Mannitol-1-phosphate/altronate dehydrogenases; altronate oxidoreductase 2625780 13702013 O3K_12875 Escherichia coli O104:H4 str. 2011C-3493 altronate oxidoreductase YP_006779265.1 2624329 D 1133852 CDS YP_006779266.1 407482117 13702014 2625987..2626901 1 NC_018658.1 COG3781 Predicted membrane protein; hypothetical protein 2626901 13702014 O3K_12880 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779266.1 2625987 D 1133852 CDS YP_006779267.1 407482118 13702015 complement(2626905..2627663) 1 NC_018658.1 COG4106 Trans-aconitate methyltransferase; trans-aconitate 2-methyltransferase 2627663 13702015 O3K_12885 Escherichia coli O104:H4 str. 2011C-3493 trans-aconitate 2-methyltransferase YP_006779267.1 2626905 R 1133852 CDS YP_006779268.1 407482119 13702016 complement(2627720..2628010) 1 NC_018658.1 COG1359 Uncharacterized conserved protein; autoinducer-2 (AI-2) modifying protein LsrG 2628010 13702016 O3K_12890 Escherichia coli O104:H4 str. 2011C-3493 autoinducer-2 (AI-2) modifying protein LsrG YP_006779268.1 2627720 R 1133852 CDS YP_006779269.1 407482120 13702017 complement(2628034..2628909) 1 NC_018658.1 COG1830 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes; autoinducer 2 aldolase 2628909 13702017 O3K_12895 Escherichia coli O104:H4 str. 2011C-3493 autoinducer 2 aldolase YP_006779269.1 2628034 R 1133852 CDS YP_006779270.1 407482121 13702018 complement(2628936..2629958) 1 NC_018658.1 COG1879 ABC-type sugar transport system, periplasmic component; autoinducer 2-binding protein lsrB 2629958 13702018 O3K_12900 Escherichia coli O104:H4 str. 2011C-3493 autoinducer 2-binding protein lsrB YP_006779270.1 2628936 R 1133852 CDS YP_006779271.1 407482122 13702090 complement(2629970..2630962) 1 NC_018658.1 COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components; autoinducer 2 import system permease LsrD 2630962 13702090 O3K_12905 Escherichia coli O104:H4 str. 2011C-3493 autoinducer 2 import system permease LsrD YP_006779271.1 2629970 R 1133852 CDS YP_006779272.1 407482123 13702091 complement(2630962..2631990) 1 NC_018658.1 COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components; autoinducer 2 ABC transporter permease LsrC 2631990 13702091 O3K_12910 Escherichia coli O104:H4 str. 2011C-3493 autoinducer 2 ABC transporter permease LsrC YP_006779272.1 2630962 R 1133852 CDS YP_006779273.1 407482124 13702092 complement(2631984..2633519) 1 NC_018658.1 COG1129 ABC-type sugar transport system, ATPase component; autoinducer 2 ABC transporter ATP-binding protein LsrA 2633519 13702092 O3K_12915 Escherichia coli O104:H4 str. 2011C-3493 autoinducer 2 ABC transporter ATP-binding protein LsrA YP_006779273.1 2631984 R 1133852 CDS YP_006779274.1 407482125 13702093 2633768..2634721 1 NC_018658.1 COG2390 Transcriptional regulator, contains sigma factor-related N-terminal domain; transcriptional regulator LsrR 2634721 13702093 O3K_12920 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator LsrR YP_006779274.1 2633768 D 1133852 CDS YP_006779275.1 407482126 13702094 2634800..2636392 1 NC_018658.1 COG1070 Sugar (pentulose and hexulose) kinases; autoinducer-2 (AI-2) kinase 2636392 13702094 O3K_12925 Escherichia coli O104:H4 str. 2011C-3493 autoinducer-2 (AI-2) kinase YP_006779275.1 2634800 D 1133852 CDS YP_006779276.1 407482127 13702095 2636923..2640900 1 NC_018658.1 COG5295 Autotransporter adhesin; lipoprotein 2640900 13702095 O3K_12930 Escherichia coli O104:H4 str. 2011C-3493 lipoprotein YP_006779276.1 2636923 D 1133852 CDS YP_006779277.1 407482128 13702096 2640944..2642344 1 NC_018658.1 COG3468 Type V secretory pathway, adhesin AidA; putative lipoprotein/autotransporter domain-containing protein 2642344 13702096 O3K_12935 Escherichia coli O104:H4 str. 2011C-3493 putative lipoprotein/autotransporter domain-containing protein YP_006779277.1 2640944 D 1133852 CDS YP_006779278.1 407482129 13702097 2642553..2642819 1 NC_018658.1 COG1396 Predicted transcriptional regulators; antitoxin HipB 2642819 13702097 O3K_12940 Escherichia coli O104:H4 str. 2011C-3493 antitoxin HipB YP_006779278.1 2642553 D 1133852 CDS YP_006779279.1 407482130 13702098 2642819..2644141 1 NC_018658.1 COG3550 Uncharacterized protein related to capsule biosynthesis enzymes; regulator with hipB 2644141 13702098 O3K_12945 Escherichia coli O104:H4 str. 2011C-3493 regulator with hipB YP_006779279.1 2642819 D 1133852 CDS YP_006779280.1 407482131 13702099 2644459..2644638 1 NC_018658.1 COG2207 AraC-type DNA-binding domain-containing proteins; transcriptional regulator 2644638 13702099 O3K_12950 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator YP_006779280.1 2644459 D 1133852 CDS YP_006779281.1 407482132 13702100 2644532..2644741 1 NC_018658.1 hypothetical protein 2644741 13702100 O3K_12955 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779281.1 2644532 D 1133852 CDS YP_006779282.1 407482133 13702101 2645094..2645657 1 NC_018658.1 COG3539 P pilus assembly protein, pilin FimA; major fimbrial subunit FmlA 2645657 13702101 O3K_12960 Escherichia coli O104:H4 str. 2011C-3493 major fimbrial subunit FmlA YP_006779282.1 2645094 D 1133852 CDS YP_006779283.1 407482134 13702102 2645991..2646701 1 NC_018658.1 COG3121 P pilus assembly protein, chaperone PapD; putative fimbrial chaperone protein 2646701 13702102 O3K_12965 Escherichia coli O104:H4 str. 2011C-3493 putative fimbrial chaperone protein YP_006779283.1 2645991 D 1133852 CDS YP_006779284.1 407482135 13702103 2646743..2649394 1 NC_018658.1 COG3188 P pilus assembly protein, porin PapC; fimbrial outer membrane usher protein 2649394 13702103 O3K_12970 Escherichia coli O104:H4 str. 2011C-3493 fimbrial outer membrane usher protein YP_006779284.1 2646743 D 1133852 CDS YP_006779285.1 407482136 13702104 2649408..2649938 1 NC_018658.1 COG3539 P pilus assembly protein, pilin FimA; fimbrial-like adhesin protein 2649938 13702104 O3K_12975 Escherichia coli O104:H4 str. 2011C-3493 fimbrial-like adhesin protein YP_006779285.1 2649408 D 1133852 CDS YP_006779286.1 407482137 13702105 2649951..2650454 1 NC_018658.1 COG3539 P pilus assembly protein, pilin FimA; fimbrial-like adhesin protein 2650454 13702105 O3K_12980 Escherichia coli O104:H4 str. 2011C-3493 fimbrial-like adhesin protein YP_006779286.1 2649951 D 1133852 CDS YP_006779287.1 407482138 13702106 2650513..2651427 1 NC_018658.1 fimbrial-like adhesin protein 2651427 13702106 O3K_12985 Escherichia coli O104:H4 str. 2011C-3493 fimbrial-like adhesin protein YP_006779287.1 2650513 D 1133852 CDS YP_006779288.1 407482139 13702107 2651761..2654040 1 NC_018658.1 COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; oxidoreductase 2654040 13702107 O3K_12990 Escherichia coli O104:H4 str. 2011C-3493 oxidoreductase YP_006779288.1 2651761 D 1133852 CDS YP_006779289.1 407482140 13702108 2654288..2654485 1 NC_018658.1 hypothetical protein 2654485 13702108 O3K_12995 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779289.1 2654288 D 1133852 CDS YP_006779290.1 407482141 13702109 2654560..2655321 1 NC_018658.1 COG2207 AraC-type DNA-binding domain-containing proteins; transcriptional regulator YdeO 2655321 13702109 O3K_13000 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator YdeO YP_006779290.1 2654560 D 1133852 CDS YP_006779291.1 407482142 13702110 2655723..2657405 1 NC_018658.1 COG3119 Arylsulfatase A and related enzymes; hypothetical protein 2657405 13702110 O3K_13005 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779291.1 2655723 D 1133852 CDS YP_006779292.1 407482143 13702111 2657457..2658614 1 NC_018658.1 COG0641 Arylsulfatase regulator (Fe-S oxidoreductase); hypothetical protein 2658614 13702111 O3K_13010 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779292.1 2657457 D 1133852 CDS YP_006779293.1 407482144 13702112 2658905..2660590 1 NC_018658.1 permease and ATP-binding component; COG4178 ABC-type uncharacterized transport system, permease and ATPase components; multidrug ABC transporter 2660590 13702112 O3K_13015 Escherichia coli O104:H4 str. 2011C-3493 multidrug ABC transporter YP_006779293.1 2658905 D 1133852 CDS YP_006779294.1 407482145 13702113 2660628..2663000 1 NC_018658.1 COG1629 Outer membrane receptor proteins, mostly Fe transport; porin protein 2663000 13702113 O3K_13020 Escherichia coli O104:H4 str. 2011C-3493 porin protein YP_006779294.1 2660628 D 1133852 CDS YP_006779295.1 407482146 13702114 2663045..2665840 1 NC_018658.1 COG0612 Predicted Zn-dependent peptidases; membrane-associated peptidase 2665840 13702114 O3K_13025 Escherichia coli O104:H4 str. 2011C-3493 membrane-associated peptidase YP_006779295.1 2663045 D 1133852 CDS YP_006779296.1 407482147 13702115 2666202..2667602 1 NC_018658.1 COG0076 Glutamate decarboxylase and related PLP-dependent proteins; glutamate decarboxylase 2667602 13702115 O3K_13030 Escherichia coli O104:H4 str. 2011C-3493 glutamate decarboxylase YP_006779296.1 2666202 D 1133852 CDS YP_006779297.1 407482148 13702116 2667758..2669293 1 NC_018658.1 COG0531 Amino acid transporters; glutamate/gamma-aminobutyrate antiporter 2669293 13702116 O3K_13035 Escherichia coli O104:H4 str. 2011C-3493 glutamate/gamma-aminobutyrate antiporter YP_006779297.1 2667758 D 1133852 CDS YP_006779298.1 407482149 13702117 2669424..2670743 1 NC_018658.1 COG1649 Uncharacterized protein conserved in bacteria; lipoprotein 2670743 13702117 O3K_13040 Escherichia coli O104:H4 str. 2011C-3493 lipoprotein YP_006779298.1 2669424 D 1133852 CDS YP_006779299.1 407482150 13702118 2671115..2672497 1 NC_018658.1 COG2199 FOG: GGDEF domain; diguanylate cyclase 2672497 13702118 O3K_13045 Escherichia coli O104:H4 str. 2011C-3493 diguanylate cyclase YP_006779299.1 2671115 D 1133852 CDS YP_006779300.1 407482151 13702119 2672522..2674921 1 NC_018658.1 COG2202 FOG: PAS/PAC domain; cyclic-di-GMP phosphodiesterase 2674921 13702119 O3K_13050 Escherichia coli O104:H4 str. 2011C-3493 cyclic-di-GMP phosphodiesterase YP_006779300.1 2672522 D 1133852 CDS YP_006779301.1 407482152 13702120 2675179..2675760 1 NC_018658.1 COG2173 D-alanyl-D-alanine dipeptidase; D-alanyl-D-alanine dipeptidase 2675760 13702120 O3K_13055 Escherichia coli O104:H4 str. 2011C-3493 D-alanyl-D-alanine dipeptidase YP_006779301.1 2675179 D 1133852 CDS YP_006779302.1 407482153 13702121 2675774..2677324 1 NC_018658.1 COG0747 ABC-type dipeptide transport system, periplasmic component; D-ala-D-a la ABC transporter substrate-binding protein 2677324 13702121 O3K_13060 Escherichia coli O104:H4 str. 2011C-3493 D-ala-D-a la ABC transporter substrate-binding protein YP_006779302.1 2675774 D 1133852 CDS YP_006779303.1 407482154 13702122 2677326..2678348 1 NC_018658.1 COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; binding-protein-dependent transporter inner membrane component 2678348 13702122 O3K_13065 Escherichia coli O104:H4 str. 2011C-3493 binding-protein-dependent transporter inner membrane component YP_006779303.1 2677326 D 1133852 CDS YP_006779304.1 407482155 13702123 2678345..2679241 1 NC_018658.1 COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; D-ala-D-ala transporter subunit 2679241 13702123 O3K_13070 Escherichia coli O104:H4 str. 2011C-3493 D-ala-D-ala transporter subunit YP_006779304.1 2678345 D 1133852 CDS YP_006779305.1 407482156 13702124 2679238..2680224 1 NC_018658.1 COG0444 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component; D-ala-D-ala ABC transporter ATP-binding protein 2680224 13702124 O3K_13075 Escherichia coli O104:H4 str. 2011C-3493 D-ala-D-ala ABC transporter ATP-binding protein YP_006779305.1 2679238 D 1133852 CDS YP_006779306.1 407482157 13702125 2680217..2681143 1 NC_018658.1 COG1124 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component; D-ala-D-ala ABC transporter ATP-binding protein 2681143 13702125 O3K_13080 Escherichia coli O104:H4 str. 2011C-3493 D-ala-D-ala ABC transporter ATP-binding protein YP_006779306.1 2680217 D 1133852 CDS YP_006779307.1 407482158 13702126 complement(2681199..2681630) 1 NC_018658.1 COG1764 Predicted redox protein, regulator of disulfide bond formation; osmotically inducible, stress-inducible membrane protein OsmC 2681630 13702126 O3K_13085 Escherichia coli O104:H4 str. 2011C-3493 osmotically inducible, stress-inducible membrane protein OsmC YP_006779307.1 2681199 R 1133852 CDS YP_006779308.1 407482159 13702127 2681976..2682191 1 NC_018658.1 biofilm-dependent modulation protein 2682191 13702127 O3K_13090 Escherichia coli O104:H4 str. 2011C-3493 biofilm-dependent modulation protein YP_006779308.1 2681976 D 1133852 CDS YP_006779309.1 407482160 13702128 2682293..2682430 1 NC_018658.1 30S ribosomal subunit S22 2682430 rpsV 13702128 rpsV Escherichia coli O104:H4 str. 2011C-3493 30S ribosomal subunit S22 YP_006779309.1 2682293 D 1133852 CDS YP_006779310.1 407482161 13702129 2682587..2684284 1 NC_018658.1 COG0281 Malic enzyme; malate dehydrogenase 2684284 13702129 O3K_13100 Escherichia coli O104:H4 str. 2011C-3493 malate dehydrogenase YP_006779310.1 2682587 D 1133852 CDS YP_006779311.1 407482162 13702130 2684418..2685428 1 NC_018658.1 COG1064 Zn-dependent alcohol dehydrogenases; ethanol-active dehydrogenase/acetaldehyde-active reductase 2685428 13702130 O3K_13105 Escherichia coli O104:H4 str. 2011C-3493 ethanol-active dehydrogenase/acetaldehyde-active reductase YP_006779311.1 2684418 D 1133852 CDS YP_006779312.1 407482163 13702131 2685575..2685859 1 NC_018658.1 COG3093 Plasmid maintenance system antidote protein; putative DNA-binding transcriptional regulator 2685859 13702131 O3K_13110 Escherichia coli O104:H4 str. 2011C-3493 putative DNA-binding transcriptional regulator YP_006779312.1 2685575 D 1133852 CDS YP_006779313.1 407482164 13702132 complement(2685910..2686563) 1 NC_018658.1 COG2864 Cytochrome b subunit of formate dehydrogenase; formate dehydrogenase-N subunit gamma 2686563 13702132 O3K_13115 Escherichia coli O104:H4 str. 2011C-3493 formate dehydrogenase-N subunit gamma YP_006779313.1 2685910 R 1133852 CDS YP_006779314.1 407482165 13702133 complement(2686556..2687440) 1 NC_018658.1 COG0437 Fe-S-cluster-containing hydrogenase components 1; formate dehydrogenase, nitrate-inducible, iron-sulfur subunit 2687440 13702133 O3K_13120 Escherichia coli O104:H4 str. 2011C-3493 formate dehydrogenase, nitrate-inducible, iron-sulfur subunit YP_006779314.1 2686556 R 1133852 CDS YP_006779315.1 407482166 13702134 2690732..2691613 1 NC_018658.1 COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; aromatic amino acid exporter 2691613 13702134 O3K_13135 Escherichia coli O104:H4 str. 2011C-3493 aromatic amino acid exporter YP_006779315.1 2690732 D 1133852 CDS YP_006779316.1 407482167 13702135 2691872..2692162 1 NC_018658.1 COG3203 Outer membrane protein (porin); lipoprotein 2692162 13702135 O3K_13140 Escherichia coli O104:H4 str. 2011C-3493 lipoprotein YP_006779316.1 2691872 D 1133852 CDS YP_006779317.1 407482168 13702136 2692186..2693517 1 NC_018658.1 COG4886 Leucine-rich repeat (LRR) protein; glycoprotein with ribonuclease inhibitor domain (yddK, modular protein) 2693517 13702136 O3K_13145 Escherichia coli O104:H4 str. 2011C-3493 glycoprotein with ribonuclease inhibitor domain (yddK, modular protein) YP_006779317.1 2692186 D 1133852 CDS YP_006779318.1 407482169 13702137 2693841..2695229 1 NC_018658.1 COG2223 Nitrate/nitrite transporter; nitrate/nitrite transport protein NarU 2695229 13702137 O3K_13150 Escherichia coli O104:H4 str. 2011C-3493 nitrate/nitrite transport protein NarU YP_006779318.1 2693841 D 1133852 CDS YP_006779319.1 407482170 13702138 2695311..2699051 1 NC_018658.1 COG5013 Nitrate reductase alpha subunit; nitrate reductase 2 subunit alpha 2699051 13702138 O3K_13155 Escherichia coli O104:H4 str. 2011C-3493 nitrate reductase 2 subunit alpha YP_006779319.1 2695311 D 1133852 CDS YP_006779320.1 407482171 13702139 2699048..2700592 1 NC_018658.1 COG1140 Nitrate reductase beta subunit; nitrate reductase 2 (NRZ) subunit beta 2700592 13702139 O3K_13160 Escherichia coli O104:H4 str. 2011C-3493 nitrate reductase 2 (NRZ) subunit beta YP_006779320.1 2699048 D 1133852 CDS YP_006779321.1 407482172 13702140 2700592..2701287 1 NC_018658.1 COG2180 Nitrate reductase delta subunit; nitrate reductase 2 subunit delta 2701287 13702140 O3K_13165 Escherichia coli O104:H4 str. 2011C-3493 nitrate reductase 2 subunit delta YP_006779321.1 2700592 D 1133852 CDS YP_006779322.1 407482173 13702141 2701284..2701964 1 NC_018658.1 COG2181 Nitrate reductase gamma subunit; nitrate reductase 2 (NRZ) subunit gamma 2701964 13702141 O3K_13170 Escherichia coli O104:H4 str. 2011C-3493 nitrate reductase 2 (NRZ) subunit gamma YP_006779322.1 2701284 D 1133852 CDS YP_006779323.1 407482174 13702142 2702043..2702936 1 NC_018658.1 COG0384 Predicted epimerase, PhzC/PhzF homolog; hypothetical protein 2702936 13702142 O3K_13175 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779323.1 2702043 D 1133852 CDS YP_006779324.1 407482175 13702143 complement(2703032..2703877) 1 NC_018658.1 COG2162 Arylamine N-acetyltransferase; N-hydroxyarylamine O-acetyltransferase 2703877 13702143 O3K_13180 Escherichia coli O104:H4 str. 2011C-3493 N-hydroxyarylamine O-acetyltransferase YP_006779324.1 2703032 R 1133852 CDS YP_006779325.1 407482176 13702144 2704050..2704619 1 NC_018658.1 COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family; hypothetical protein 2704619 13702144 O3K_13185 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779325.1 2704050 D 1133852 CDS YP_006779326.1 407482177 13702145 complement(2704623..2704850) 1 NC_018658.1 COG1942 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog; 4-oxalocrotonate tautomerase 2704850 13702145 O3K_13190 Escherichia coli O104:H4 str. 2011C-3493 4-oxalocrotonate tautomerase YP_006779326.1 2704623 R 1133852 CDS YP_006779327.1 407482178 13702146 complement(2704883..2705581) 1 NC_018658.1 COG5433 Transposase; H repeat-associated protein 2705581 13702146 O3K_13195 Escherichia coli O104:H4 str. 2011C-3493 H repeat-associated protein YP_006779327.1 2704883 R 1133852 CDS YP_006779328.1 407482179 13702147 complement(2705935..2706384) 1 NC_018658.1 hypothetical protein 2706384 13702147 O3K_13200 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779328.1 2705935 R 1133852 CDS YP_006779329.1 407482180 13702148 complement(2706396..2710637) 1 NC_018658.1 COG3209 Rhs family protein; rhsD element protein 2710637 13702148 O3K_13205 Escherichia coli O104:H4 str. 2011C-3493 rhsD element protein YP_006779329.1 2706396 R 1133852 CDS YP_006779330.1 407482181 13702149 complement(2710705..2712813) 1 NC_018658.1 Encoded within repeats that are hotspots for chromosomal duplication formation; COG3501 Uncharacterized protein conserved in bacteria; hypothetical protein 2712813 13702149 O3K_13210 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779330.1 2710705 R 1133852 CDS YP_006779331.1 407482182 13702150 complement(2713633..2713845) 1 NC_018658.1 hypothetical protein 2713845 13702150 O3K_13215 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779331.1 2713633 R 1133852 CDS YP_006779332.1 407482183 13702151 complement(2713921..2714538) 1 NC_018658.1 COG0625 Glutathione S-transferase; glutathione S-transferase-like protein 2714538 13702151 O3K_13220 Escherichia coli O104:H4 str. 2011C-3493 glutathione S-transferase-like protein YP_006779332.1 2713921 R 1133852 CDS YP_006779333.1 407482184 13702152 2714805..2716304 1 NC_018658.1 COG1113 Gamma-aminobutyrate permease and related permeases; L-asparagine permease 2716304 13702152 O3K_13225 Escherichia coli O104:H4 str. 2011C-3493 L-asparagine permease YP_006779333.1 2714805 D 1133852 CDS YP_006779334.1 407482185 13702153 complement(2716417..2717478) 1 NC_018658.1 COG3391 Uncharacterized conserved protein; hypothetical protein 2717478 13702153 O3K_13230 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779334.1 2716417 R 1133852 CDS YP_006779335.1 407482186 13702154 2717720..2719822 1 NC_018658.1 COG1629 Outer membrane receptor proteins, mostly Fe transport; iron outer membrane receptor 2719822 13702154 O3K_13235 Escherichia coli O104:H4 str. 2011C-3493 iron outer membrane receptor YP_006779335.1 2717720 D 1133852 CDS YP_006779336.1 407482187 13702155 complement(2719858..2720523) 1 NC_018658.1 COG1802 Transcriptional regulators; colanic acid/biofilm transcriptional regulator 2720523 13702155 O3K_13240 Escherichia coli O104:H4 str. 2011C-3493 colanic acid/biofilm transcriptional regulator YP_006779336.1 2719858 R 1133852 CDS YP_006779337.1 407482188 13702156 complement(2720721..2721758) 1 NC_018658.1 COG2130 Putative NADP-dependent oxidoreductases; oxidoreductase 2721758 13702156 O3K_13245 Escherichia coli O104:H4 str. 2011C-3493 oxidoreductase YP_006779337.1 2720721 R 1133852 CDS YP_006779338.1 407482189 13702157 2721939..2722457 1 NC_018658.1 COG1247 Sortase and related acyltransferases; acyl-CoA N-acyltransferase 2722457 13702157 O3K_13250 Escherichia coli O104:H4 str. 2011C-3493 acyl-CoA N-acyltransferase YP_006779338.1 2721939 D 1133852 CDS YP_006779339.1 407482190 13702158 2722454..2722903 1 NC_018658.1 COG3238 Uncharacterized protein conserved in bacteria; inner membrane protein 2722903 13702158 O3K_13255 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006779339.1 2722454 D 1133852 CDS YP_006779340.1 407482191 13702159 complement(2722904..2723137) 1 NC_018658.1 hypothetical protein 2723137 13702159 O3K_13260 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779340.1 2722904 R 1133852 CDS YP_006779341.1 407482192 13702160 complement(2723223..2723396) 1 NC_018658.1 hypothetical protein 2723396 13702160 O3K_13265 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779341.1 2723223 R 1133852 CDS YP_006779342.1 407482193 13702161 complement(2724088..2724897) 1 NC_018658.1 COG0110 Acetyltransferase (isoleucine patch superfamily); acetyltransferase 2724897 13702161 O3K_13270 Escherichia coli O104:H4 str. 2011C-3493 acetyltransferase YP_006779342.1 2724088 R 1133852 CDS YP_006779343.1 407482194 13702162 complement(2725107..2726531) 1 NC_018658.1 COG1012 NAD-dependent aldehyde dehydrogenases; gamma-aminobutyraldehyde dehydrogenase 2726531 13702162 O3K_13275 Escherichia coli O104:H4 str. 2011C-3493 gamma-aminobutyraldehyde dehydrogenase YP_006779343.1 2725107 R 1133852 CDS YP_006779344.1 407482195 13702163 complement(2726553..2727347) 1 NC_018658.1 COG1177 ABC-type spermidine/putrescine transport system, permease component II; spermidine/putrescine ABC transporter permease 2727347 13702163 O3K_13280 Escherichia coli O104:H4 str. 2011C-3493 spermidine/putrescine ABC transporter permease YP_006779344.1 2726553 R 1133852 CDS YP_006779345.1 407482196 13702164 complement(2727337..2728278) 1 NC_018658.1 COG1176 ABC-type spermidine/putrescine transport system, permease component I; ABC transporter permease 2728278 13702164 O3K_13285 Escherichia coli O104:H4 str. 2011C-3493 ABC transporter permease YP_006779345.1 2727337 R 1133852 CDS YP_006779346.1 407482197 13702165 complement(2728279..2729292) 1 NC_018658.1 COG3842 ABC-type spermidine/putrescine transport systems, ATPase components; spermidine/putrescine ABC transporter ATP-binding protein 2729292 13702165 O3K_13290 Escherichia coli O104:H4 str. 2011C-3493 spermidine/putrescine ABC transporter ATP-binding protein YP_006779346.1 2728279 R 1133852 CDS YP_006779347.1 407482198 13702166 complement(2729310..2730455) 1 NC_018658.1 COG0687 Spermidine/putrescine-binding periplasmic protein; putative spermidine/putrescine transporter subunit 2730455 13702166 O3K_13295 Escherichia coli O104:H4 str. 2011C-3493 putative spermidine/putrescine transporter subunit YP_006779347.1 2729310 R 1133852 CDS YP_006779348.1 407482199 13702167 complement(2730700..2732106) 1 NC_018658.1 transcriptional regulator, GntR family; COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs; GntR family transcriptional regulator 2732106 13702167 O3K_13300 Escherichia coli O104:H4 str. 2011C-3493 GntR family transcriptional regulator YP_006779348.1 2730700 R 1133852 CDS YP_006779349.1 407482200 13702168 complement(2732185..2732622) 1 NC_018658.1 COG1598 Uncharacterized conserved protein; DNA-binding transcriptional regulator 2732622 13702168 O3K_13305 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator YP_006779349.1 2732185 R 1133852 CDS YP_006779350.1 407482201 13702239 2733023..2733253 1 NC_018658.1 hypothetical protein 2733253 13702239 O3K_13310 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779350.1 2733023 D 1133852 CDS YP_006779351.1 407482202 13702240 complement(2733345..2735306) 1 NC_018658.1 COG0826 Collagenase and related proteases; peptidase, U32 family protein 2735306 13702240 O3K_13315 Escherichia coli O104:H4 str. 2011C-3493 peptidase, U32 family protein YP_006779351.1 2733345 R 1133852 CDS YP_006779352.1 407482203 13702241 complement(2735379..2735915) 1 NC_018658.1 COG1396 Predicted transcriptional regulators; putative DNA-binding transcriptional regulator 2735915 13702241 O3K_13320 Escherichia coli O104:H4 str. 2011C-3493 putative DNA-binding transcriptional regulator YP_006779352.1 2735379 R 1133852 CDS YP_006779353.1 407482204 13702242 2736007..2737182 1 NC_018658.1 COG3135 Uncharacterized protein involved in benzoate metabolism; putative benzoate transporter 2737182 13702242 O3K_13325 Escherichia coli O104:H4 str. 2011C-3493 putative benzoate transporter YP_006779353.1 2736007 D 1133852 CDS YP_006779354.1 407482205 13702243 complement(2737222..2738430) 1 NC_018658.1 COG0675 Transposase and inactivated derivatives; transposase 2738430 13702243 O3K_13330 Escherichia coli O104:H4 str. 2011C-3493 transposase YP_006779354.1 2737222 R 1133852 CDS YP_006779355.1 407482206 13702244 complement(2738957..2739625) 1 NC_018658.1 hypothetical protein 2739625 13702244 O3K_13345 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779355.1 2738957 R 1133852 CDS YP_006779356.1 407482207 13702245 complement(2739928..2740521) 1 NC_018658.1 COG0500 SAM-dependent methyltransferases; tellurite resistance protein TehB 2740521 13702245 O3K_13350 Escherichia coli O104:H4 str. 2011C-3493 tellurite resistance protein TehB YP_006779356.1 2739928 R 1133852 CDS YP_006779357.1 407482208 13702246 complement(2740518..2741510) 1 NC_018658.1 COG1275 Tellurite resistance protein and related permeases; potassium-tellurite ethidium and proflavin transporter 2741510 13702246 O3K_13355 Escherichia coli O104:H4 str. 2011C-3493 potassium-tellurite ethidium and proflavin transporter YP_006779357.1 2740518 R 1133852 CDS YP_006779358.1 407482209 13702247 2741634..2742614 1 NC_018658.1 COG1044 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; hypothetical protein 2742614 13702247 O3K_13360 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779358.1 2741634 D 1133852 CDS YP_006779359.1 407482210 13702248 complement(2742609..2743145) 1 NC_018658.1 COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins; ribosomal-protein-L7/L12-serine acetyltransferase 2743145 13702248 O3K_13365 Escherichia coli O104:H4 str. 2011C-3493 ribosomal-protein-L7/L12-serine acetyltransferase YP_006779359.1 2742609 R 1133852 CDS YP_006779360.1 407482211 13702249 complement(2743208..2743432) 1 NC_018658.1 COG2841 Uncharacterized protein conserved in bacteria; hypothetical protein 2743432 13702249 O3K_13370 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779360.1 2743208 R 1133852 CDS YP_006779361.1 407482212 13702250 2743448..2743651 1 NC_018658.1 hypothetical protein 2743651 13702250 O3K_13375 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779361.1 2743448 D 1133852 CDS YP_006779362.1 407482213 13702251 complement(2743572..2745227) 1 NC_018658.1 COG3131 Periplasmic glucans biosynthesis protein; glucan biosynthesis protein D 2745227 mdoD 13702251 mdoD Escherichia coli O104:H4 str. 2011C-3493 glucan biosynthesis protein D YP_006779362.1 2743572 R 1133852 CDS YP_006779363.1 407482214 13702252 complement(2745452..2746795) 1 NC_018658.1 COG5383 Uncharacterized protein conserved in bacteria; hypothetical protein 2746795 13702252 O3K_13385 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779363.1 2745452 R 1133852 CDS YP_006779364.1 407482215 13702253 2747012..2747935 1 NC_018658.1 COG0583 Transcriptional regulator; transcriptional regulator 2747935 13702253 O3K_13390 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator YP_006779364.1 2747012 D 1133852 CDS YP_006779365.1 407482216 13702254 complement(2747973..2749613) 1 NC_018658.1 COG0840 Methyl-accepting chemotaxis protein; methyl-accepting chemotaxis protein III, ribose and galactose sensor receptor 2749613 13702254 O3K_13395 Escherichia coli O104:H4 str. 2011C-3493 methyl-accepting chemotaxis protein III, ribose and galactose sensor receptor YP_006779365.1 2747973 R 1133852 CDS YP_006779366.1 407482217 13702255 2750012..2750161 1 NC_018658.1 small toxic polypeptide 2750161 13702255 O3K_13400 Escherichia coli O104:H4 str. 2011C-3493 small toxic polypeptide YP_006779366.1 2750012 D 1133852 CDS YP_006779367.1 407482218 13702256 complement(2750233..2750406) 1 NC_018658.1 hypothetical protein 2750406 13702256 O3K_13405 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779367.1 2750233 R 1133852 CDS YP_006779368.1 407482219 13702257 complement(2750651..2751181) 1 NC_018658.1 COG3038 Cytochrome B561; cytochrome b561 2751181 13702257 O3K_13410 Escherichia coli O104:H4 str. 2011C-3493 cytochrome b561 YP_006779368.1 2750651 R 1133852 CDS YP_006779369.1 407482220 13702258 2751370..2752371 1 NC_018658.1 COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; glyceraldehyde-3-phosphate dehydrogenase 2752371 13702258 O3K_13415 Escherichia coli O104:H4 str. 2011C-3493 glyceraldehyde-3-phosphate dehydrogenase YP_006779369.1 2751370 D 1133852 CDS YP_006779370.1 407482221 13702259 complement(2752413..2753852) 1 NC_018658.1 COG1012 NAD-dependent aldehyde dehydrogenases; aldehyde dehydrogenase A 2753852 13702259 O3K_13420 Escherichia coli O104:H4 str. 2011C-3493 aldehyde dehydrogenase A YP_006779370.1 2752413 R 1133852 CDS YP_006779371.1 407482222 13702260 complement(2754049..2754849) 1 NC_018658.1 COG1434 Uncharacterized conserved protein; hypothetical protein 2754849 13702260 O3K_13425 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779371.1 2754049 R 1133852 CDS YP_006779372.1 407482223 13702261 complement(2755121..2758966) 1 NC_018658.1 COG1643 HrpA-like helicases; ATP-dependent RNA helicase HrpA 2758966 13702261 O3K_13430 Escherichia coli O104:H4 str. 2011C-3493 ATP-dependent RNA helicase HrpA YP_006779372.1 2755121 R 1133852 CDS YP_006779373.1 407482224 13702262 2759224..2759829 1 NC_018658.1 COG1182 Acyl carrier protein phosphodiesterase; azoreductase 2759829 13702262 O3K_13435 Escherichia coli O104:H4 str. 2011C-3493 azoreductase YP_006779373.1 2759224 D 1133852 CDS YP_006779374.1 407482225 13702263 complement(2759880..2761172) 1 NC_018658.1 COG0671 Membrane-associated phospholipid phosphatase; membrane associated phosphatase 2761172 13702263 O3K_13440 Escherichia coli O104:H4 str. 2011C-3493 membrane associated phosphatase YP_006779374.1 2759880 R 1133852 CDS YP_006779375.1 407482226 13702264 complement(2761186..2762943) 1 NC_018658.1 COG2267 Lysophospholipase; hydrolase 2762943 13702264 O3K_13445 Escherichia coli O104:H4 str. 2011C-3493 hydrolase YP_006779375.1 2761186 R 1133852 CDS YP_006779376.1 407482227 13702265 complement(2762959..2763855) 1 NC_018658.1 COG4589 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase; membrane associated CTP-phosphosubstrate transferase 2763855 13702265 O3K_13450 Escherichia coli O104:H4 str. 2011C-3493 membrane associated CTP-phosphosubstrate transferase YP_006779376.1 2762959 R 1133852 CDS YP_006779377.1 407482228 13702266 complement(2763855..2764460) 1 NC_018658.1 COG0558 Phosphatidylglycerophosphate synthase; inner membrane protein 2764460 13702266 O3K_13455 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006779377.1 2763855 R 1133852 CDS YP_006779378.1 407482229 13702267 complement(2764631..2766937) 1 NC_018658.1 hypothetical protein 2766937 13702267 O3K_13460 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779378.1 2764631 R 1133852 CDS YP_006779379.1 407482230 13702268 complement(2767001..2767861) 1 NC_018658.1 COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases); oxidoreductase 2767861 13702268 O3K_13465 Escherichia coli O104:H4 str. 2011C-3493 oxidoreductase YP_006779379.1 2767001 R 1133852 CDS YP_006779380.1 407482231 13702269 complement(2768091..2768681) 1 NC_018658.1 COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily; hexapeptide repeat acetyltransferase 2768681 13702269 O3K_13470 Escherichia coli O104:H4 str. 2011C-3493 hexapeptide repeat acetyltransferase YP_006779380.1 2768091 R 1133852 CDS YP_006779381.1 407482232 13702270 complement(2768663..2769613) 1 NC_018658.1 COG3327 Phenylacetic acid-responsive transcriptional repressor; DNA-binding transcriptional repressor of phenylacetic acid degradation, aryl-CoA responsive 2769613 13702270 O3K_13475 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional repressor of phenylacetic acid degradation, aryl-CoA responsive YP_006779381.1 2768663 R 1133852 CDS YP_006779382.1 407482233 13702271 complement(2769714..2771027) 1 NC_018658.1 COG1541 Coenzyme F390 synthetase; phenylacetate-CoA ligase 2771027 13702271 O3K_13480 Escherichia coli O104:H4 str. 2011C-3493 phenylacetate-CoA ligase YP_006779382.1 2769714 R 1133852 CDS YP_006779383.1 407482234 13702272 complement(2771054..2772259) 1 NC_018658.1 COG0183 Acetyl-CoA acetyltransferase; beta-ketoadipyl CoA thiolase 2772259 13702272 O3K_13485 Escherichia coli O104:H4 str. 2011C-3493 beta-ketoadipyl CoA thiolase YP_006779383.1 2771054 R 1133852 CDS YP_006779384.1 407482235 13702273 complement(2772259..2772681) 1 NC_018658.1 COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism; thioesterase 2772681 13702273 O3K_13490 Escherichia coli O104:H4 str. 2011C-3493 thioesterase YP_006779384.1 2772259 R 1133852 CDS YP_006779385.1 407482236 13702274 complement(2772671..2774098) 1 NC_018658.1 COG1250 3-hydroxyacyl-CoA dehydrogenase; 3-hydroxyacyl-CoA dehydrogenase 2774098 13702274 O3K_13495 Escherichia coli O104:H4 str. 2011C-3493 3-hydroxyacyl-CoA dehydrogenase YP_006779385.1 2772671 R 1133852 CDS YP_006779386.1 407482237 13702275 complement(2774100..2774888) 1 NC_018658.1 COG1024 Enoyl-CoA hydratase/carnithine racemase; enoyl-CoA hydratase 2774888 13702275 O3K_13500 Escherichia coli O104:H4 str. 2011C-3493 enoyl-CoA hydratase YP_006779386.1 2774100 R 1133852 CDS YP_006779387.1 407482238 13702276 complement(2774888..2775655) 1 NC_018658.1 COG1024 Enoyl-CoA hydratase/carnithine racemase; enoyl-CoA hydratase-isomerase 2775655 13702276 O3K_13505 Escherichia coli O104:H4 str. 2011C-3493 enoyl-CoA hydratase-isomerase YP_006779387.1 2774888 R 1133852 CDS YP_006779388.1 407482239 13702277 complement(2775652..2776722) 1 NC_018658.1 COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1; subunit of the phenylacetly-CoA oxygenase/reductase 2776722 13702277 O3K_13510 Escherichia coli O104:H4 str. 2011C-3493 subunit of the phenylacetly-CoA oxygenase/reductase YP_006779388.1 2775652 R 1133852 CDS YP_006779389.1 407482240 13702278 complement(2776730..2777227) 1 NC_018658.1 COG2151 Predicted metal-sulfur cluster biosynthetic enzyme; putative multicomponent oxygenase/reductase subunit 2777227 13702278 O3K_13515 Escherichia coli O104:H4 str. 2011C-3493 putative multicomponent oxygenase/reductase subunit YP_006779389.1 2776730 R 1133852 CDS YP_006779390.1 407482241 13702279 complement(2777242..2777988) 1 NC_018658.1 COG3396 Uncharacterized conserved protein; putative multicomponent oxygenase/reductase subunit 2777988 13702279 O3K_13520 Escherichia coli O104:H4 str. 2011C-3493 putative multicomponent oxygenase/reductase subunit YP_006779390.1 2777242 R 1133852 CDS YP_006779391.1 407482242 13702280 complement(2777997..2778284) 1 NC_018658.1 COG3460 Uncharacterized enzyme of phenylacetate metabolism; phenylacetate-CoA oxygenase subunit PaaB 2778284 paaB 13702280 paaB Escherichia coli O104:H4 str. 2011C-3493 phenylacetate-CoA oxygenase subunit PaaB YP_006779391.1 2777997 R 1133852 CDS YP_006779392.1 407482243 13702281 complement(2778296..2779225) 1 NC_018658.1 COG3396 Uncharacterized conserved protein; phenylacetate-CoA oxygenase subunit PaaA 2779225 paaA 13702281 paaA Escherichia coli O104:H4 str. 2011C-3493 phenylacetate-CoA oxygenase subunit PaaA YP_006779392.1 2778296 R 1133852 CDS YP_006779393.1 407482244 13702282 2779510..2781555 1 NC_018658.1 COG1012 NAD-dependent aldehyde dehydrogenases; bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase 2781555 13702282 O3K_13535 Escherichia coli O104:H4 str. 2011C-3493 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase YP_006779393.1 2779510 D 1133852 CDS YP_006779394.1 407482245 13702283 2781803..2784076 1 NC_018658.1 COG3733 Cu2+-containing amine oxidase; tyramine oxidase 2784076 tynA 13702283 tynA Escherichia coli O104:H4 str. 2011C-3493 tyramine oxidase YP_006779394.1 2781803 D 1133852 CDS YP_006779395.1 407482246 13702284 complement(2784134..2785633) 1 NC_018658.1 COG1012 NAD-dependent aldehyde dehydrogenases; phenylacetaldehyde dehydrogenase 2785633 13702284 O3K_13545 Escherichia coli O104:H4 str. 2011C-3493 phenylacetaldehyde dehydrogenase YP_006779395.1 2784134 R 1133852 CDS YP_006779396.1 407482247 13702285 2785869..2786774 1 NC_018658.1 COG2207 AraC-type DNA-binding domain-containing proteins; DNA-binding transcriptional activator FeaR 2786774 13702285 O3K_13550 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional activator FeaR YP_006779396.1 2785869 D 1133852 CDS YP_006779397.1 407482248 13702286 complement(2786946..2787272) 1 NC_018658.1 COG3784 Uncharacterized protein conserved in bacteria; hypothetical protein 2787272 13702286 O3K_13555 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779397.1 2786946 R 1133852 CDS YP_006779398.1 407482249 13702287 complement(2787280..2787465) 1 NC_018658.1 lipoprotein 2787465 13702287 O3K_13560 Escherichia coli O104:H4 str. 2011C-3493 lipoprotein YP_006779398.1 2787280 R 1133852 CDS YP_006779399.1 407482250 13702288 complement(2787462..2790101) 1 NC_018658.1 hypothetical protein 2790101 13702288 O3K_13565 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779399.1 2787462 R 1133852 CDS YP_006779400.1 407482251 13702289 2790309..2791298 1 NC_018658.1 COG1052 Lactate dehydrogenase and related dehydrogenases; D-lactate dehydrogenase 2791298 13702289 O3K_13570 Escherichia coli O104:H4 str. 2011C-3493 D-lactate dehydrogenase YP_006779400.1 2790309 D 1133852 CDS YP_006779401.1 407482252 13702290 2791409..2791831 1 NC_018658.1 COG3187 Heat shock protein; heat-inducible protein 2791831 13702290 O3K_13575 Escherichia coli O104:H4 str. 2011C-3493 heat-inducible protein YP_006779401.1 2791409 D 1133852 CDS YP_006779402.1 407482253 13702291 complement(2791828..2792094) 1 NC_018658.1 COG3042 Putative hemolysin; hypothetical protein 2792094 13702291 O3K_13580 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779402.1 2791828 R 1133852 CDS YP_006779403.1 407482254 13702292 2792368..2795892 1 NC_018658.1 COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit; 2-oxoacid-flavodoxin oxidoreductase 2795892 13702292 O3K_13585 Escherichia coli O104:H4 str. 2011C-3493 2-oxoacid-flavodoxin oxidoreductase YP_006779403.1 2792368 D 1133852 CDS YP_006779404.1 407482255 13702293 2796259..2797392 1 NC_018658.1 COG3203 Outer membrane protein (porin); outer membrane pore protein N, non-specific 2797392 13702293 O3K_13590 Escherichia coli O104:H4 str. 2011C-3493 outer membrane pore protein N, non-specific YP_006779404.1 2796259 D 1133852 CDS YP_006779405.1 407482256 13702294 2797533..2797967 1 NC_018658.1 COG0589 Universal stress protein UspA and related nucleotide-binding proteins; universal stress protein F 2797967 13702294 O3K_13595 Escherichia coli O104:H4 str. 2011C-3493 universal stress protein F YP_006779405.1 2797533 D 1133852 CDS YP_006779406.1 407482257 13702295 2798143..2799078 1 NC_018658.1 COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control; tRNA 2-thiocytidine biosynthesis protein TtcA 2799078 13702295 O3K_13600 Escherichia coli O104:H4 str. 2011C-3493 tRNA 2-thiocytidine biosynthesis protein TtcA YP_006779406.1 2798143 D 1133852 CDS YP_006779407.1 407482258 13702296 complement(2799207..2800580) 1 NC_018658.1 COG0513 Superfamily II DNA and RNA helicases; ATP-dependent RNA helicase DbpA 2800580 13702296 O3K_13605 Escherichia coli O104:H4 str. 2011C-3493 ATP-dependent RNA helicase DbpA YP_006779407.1 2799207 R 1133852 CDS YP_006779408.1 407482259 13702297 complement(2800610..2800783) 1 NC_018658.1 hypothetical protein 2800783 13702297 O3K_13610 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779408.1 2800610 R 1133852 CDS YP_006779409.1 407482260 13702298 complement(2801058..2802041) 1 NC_018658.1 COG0598 Mg2+ and Co2+ transporters; zinc transporter 2802041 zntB 13702298 zntB Escherichia coli O104:H4 str. 2011C-3493 zinc transporter YP_006779409.1 2801058 R 1133852 CDS YP_006779410.1 407482261 13702299 2802296..2803528 1 NC_018658.1 COG2199 FOG: GGDEF domain; hypothetical protein 2803528 13702299 O3K_13620 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779410.1 2802296 D 1133852 CDS YP_006779411.1 407482262 13702300 complement(2803549..2804112) 1 NC_018658.1 COG2840 Uncharacterized protein conserved in bacteria; Smr domain-containing protein 2804112 13702300 O3K_13625 Escherichia coli O104:H4 str. 2011C-3493 Smr domain-containing protein YP_006779411.1 2803549 R 1133852 CDS YP_006779412.1 407482263 13702301 complement(2804442..2805350) 1 NC_018658.1 COG0583 Transcriptional regulator; putative DNA-binding transcriptional regulator 2805350 13702301 O3K_13630 Escherichia coli O104:H4 str. 2011C-3493 putative DNA-binding transcriptional regulator YP_006779412.1 2804442 R 1133852 CDS YP_006779413.1 407482264 13702302 2805526..2806836 1 NC_018658.1 COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase; putative peptidase, aminobenzoyl-glutamate utilization protein AbgA 2806836 13702302 O3K_13635 Escherichia coli O104:H4 str. 2011C-3493 putative peptidase, aminobenzoyl-glutamate utilization protein AbgA YP_006779413.1 2805526 D 1133852 CDS YP_006779414.1 407482265 13702303 2806836..2808281 1 NC_018658.1 COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase; peptidase, aminobenzoyl-glutamate utilization protein AbgB 2808281 13702303 O3K_13640 Escherichia coli O104:H4 str. 2011C-3493 peptidase, aminobenzoyl-glutamate utilization protein AbgB YP_006779414.1 2806836 D 1133852 CDS YP_006779415.1 407482266 13702304 2808318..2809844 1 NC_018658.1 COG2978 Putative p-aminobenzoyl-glutamate transporter; putative aminobenzoyl-glutamate transporter 2809844 abgT 13702304 abgT Escherichia coli O104:H4 str. 2011C-3493 putative aminobenzoyl-glutamate transporter YP_006779415.1 2808318 D 1133852 CDS YP_006779416.1 407482267 13702305 2809855..2810370 1 NC_018658.1 COG0350 Methylated DNA-protein cysteine methyltransferase; O-6-alkylguanine-DNA:cysteine-protein methyltransferase 2810370 13702305 O3K_13650 Escherichia coli O104:H4 str. 2011C-3493 O-6-alkylguanine-DNA:cysteine-protein methyltransferase YP_006779416.1 2809855 D 1133852 CDS YP_006779417.1 407482268 13702306 2810565..2811317 1 NC_018658.1 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases; fumarate/nitrate reduction transcriptional regulator 2811317 13702306 O3K_13655 Escherichia coli O104:H4 str. 2011C-3493 fumarate/nitrate reduction transcriptional regulator YP_006779417.1 2810565 D 1133852 CDS YP_006779418.1 407482269 13702377 2811469..2812419 1 NC_018658.1 COG0589 Universal stress protein UspA and related nucleotide-binding proteins; universal stress protein UspE 2812419 13702377 O3K_13660 Escherichia coli O104:H4 str. 2011C-3493 universal stress protein UspE YP_006779418.1 2811469 D 1133852 CDS YP_006779419.1 407482270 13702378 complement(2812469..2812726) 1 NC_018658.1 hypothetical protein 2812726 13702378 O3K_13665 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779419.1 2812469 R 1133852 CDS YP_006779420.1 407482271 13702379 2812970..2814001 1 NC_018658.1 COG0668 Small-conductance mechanosensitive channel; MscS family inner membrane protein YnaI 2814001 13702379 O3K_13670 Escherichia coli O104:H4 str. 2011C-3493 MscS family inner membrane protein YnaI YP_006779420.1 2812970 D 1133852 CDS YP_006779421.1 407482272 13702380 complement(2814052..2815665) 1 NC_018658.1 COG4166 ABC-type oligopeptide transport system, periplasmic component; transport periplasmic protein 2815665 13702380 O3K_13675 Escherichia coli O104:H4 str. 2011C-3493 transport periplasmic protein YP_006779421.1 2814052 R 1133852 CDS YP_006779422.1 407482273 13702381 complement(2815788..2815913) 1 NC_018658.1 hypothetical protein 2815913 13702381 O3K_13680 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779422.1 2815788 R 1133852 CDS YP_006779423.1 407482274 13702382 complement(2816002..2816901) 1 NC_018658.1 COG0583 Transcriptional regulator; LysR family transcriptional regulator 2816901 13702382 O3K_13685 Escherichia coli O104:H4 str. 2011C-3493 LysR family transcriptional regulator YP_006779423.1 2816002 R 1133852 CDS YP_006779424.1 407482275 13702383 2817027..2817959 1 NC_018658.1 COG1073 Hydrolases of the alpha/beta superfamily; hydrolase 2817959 13702383 O3K_13690 Escherichia coli O104:H4 str. 2011C-3493 hydrolase YP_006779424.1 2817027 D 1133852 CDS YP_006779425.1 407482276 13702384 2818030..2818194 1 NC_018658.1 COG0702 Predicted nucleoside-diphosphate-sugar epimerases; hypothetical protein 2818194 13702384 O3K_13695 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779425.1 2818030 D 1133852 CDS YP_006779426.1 407482277 13702385 2818295..2819023 1 NC_018658.1 COG2866 Predicted carboxypeptidase; murein peptide amidase A 2819023 13702385 O3K_13700 Escherichia coli O104:H4 str. 2011C-3493 murein peptide amidase A YP_006779426.1 2818295 D 1133852 CDS YP_006779427.1 407482278 13702386 complement(2818998..2819963) 1 NC_018658.1 COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily; L-Ala-D/L-Glu epimerase 2819963 13702386 O3K_13705 Escherichia coli O104:H4 str. 2011C-3493 L-Ala-D/L-Glu epimerase YP_006779427.1 2818998 R 1133852 CDS YP_006779428.1 407482279 13702387 2820082..2820588 1 NC_018658.1 COG2077 Peroxiredoxin; lipid hydroperoxide peroxidase 2820588 tpx 13702387 tpx Escherichia coli O104:H4 str. 2011C-3493 lipid hydroperoxide peroxidase YP_006779428.1 2820082 D 1133852 CDS YP_006779429.1 407482280 13702388 complement(2820632..2822173) 1 NC_018658.1 COG3283 Transcriptional regulator of aromatic amino acids metabolism; DNA-binding transcriptional regulator TyrR 2822173 13702388 O3K_13715 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator TyrR YP_006779429.1 2820632 R 1133852 CDS YP_006779430.1 407482281 13702389 complement(2822321..2823382) 1 NC_018658.1 COG3768 Predicted membrane protein; hypothetical protein 2823382 13702389 O3K_13720 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779430.1 2822321 R 1133852 CDS YP_006779431.1 407482282 13702390 complement(2823379..2824776) 1 NC_018658.1 COG3106 Predicted ATPase; hypothetical protein 2824776 13702390 O3K_13725 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779431.1 2823379 R 1133852 CDS YP_006779432.1 407482283 13702391 2824931..2825929 1 NC_018658.1 COG1609 Transcriptional regulators; DNA-binding transcriptional regulator 2825929 13702391 O3K_13730 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator YP_006779432.1 2824931 D 1133852 CDS YP_006779433.1 407482284 13702392 complement(2826040..2826945) 1 NC_018658.1 outer membrane porin 2826945 13702392 O3K_13735 Escherichia coli O104:H4 str. 2011C-3493 outer membrane porin YP_006779433.1 2826040 R 1133852 CDS YP_006779434.1 407482285 13702393 complement(2826990..2828072) 1 NC_018658.1 COG3839 ABC-type sugar transport systems, ATPase components; sugar transporter subunit 2828072 13702393 O3K_13740 Escherichia coli O104:H4 str. 2011C-3493 sugar transporter subunit YP_006779434.1 2826990 R 1133852 CDS YP_006779435.1 407482286 13702394 complement(2828086..2828745) 1 NC_018658.1 COG0637 Predicted phosphatase/phosphohexomutase; putative beta-phosphoglucomutase 2828745 13702394 O3K_13745 Escherichia coli O104:H4 str. 2011C-3493 putative beta-phosphoglucomutase YP_006779435.1 2828086 R 1133852 CDS YP_006779436.1 407482287 13702395 complement(2828742..2831009) 1 NC_018658.1 COG1554 Trehalose and maltose hydrolases (possible phosphorylases); hydrolase 2831009 13702395 O3K_13750 Escherichia coli O104:H4 str. 2011C-3493 hydrolase YP_006779436.1 2828742 R 1133852 CDS YP_006779437.1 407482288 13702396 complement(2831006..2832061) 1 NC_018658.1 COG0673 Predicted dehydrogenases and related proteins; oxidoreductase 2832061 13702396 O3K_13755 Escherichia coli O104:H4 str. 2011C-3493 oxidoreductase YP_006779437.1 2831006 R 1133852 CDS YP_006779438.1 407482289 13702397 complement(2832071..2832859) 1 NC_018658.1 COG1082 Sugar phosphate isomerases/epimerases; hypothetical protein 2832859 13702397 O3K_13760 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779438.1 2832071 R 1133852 CDS YP_006779439.1 407482290 13702398 complement(2832877..2833929) 1 NC_018658.1 COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases; oxidoreductase, Zn-dependent and NAD(P)-binding protein 2833929 13702398 O3K_13765 Escherichia coli O104:H4 str. 2011C-3493 oxidoreductase, Zn-dependent and NAD(P)-binding protein YP_006779439.1 2832877 R 1133852 CDS YP_006779440.1 407482291 13702399 complement(2833960..2834802) 1 NC_018658.1 COG0395 ABC-type sugar transport system, permease component; putative sugar transporter subunit 2834802 13702399 O3K_13770 Escherichia coli O104:H4 str. 2011C-3493 putative sugar transporter subunit YP_006779440.1 2833960 R 1133852 CDS YP_006779441.1 407482292 13702400 complement(2834789..2835670) 1 NC_018658.1 COG1175 ABC-type sugar transport systems, permease components; putative sugar transporter subunit 2835670 13702400 O3K_13775 Escherichia coli O104:H4 str. 2011C-3493 putative sugar transporter subunit YP_006779441.1 2834789 R 1133852 CDS YP_006779442.1 407482293 13702401 complement(2835691..2836983) 1 NC_018658.1 COG1653 ABC-type sugar transport system, periplasmic component; putative sugar transporter subunit 2836983 13702401 O3K_13780 Escherichia coli O104:H4 str. 2011C-3493 putative sugar transporter subunit YP_006779442.1 2835691 R 1133852 CDS YP_006779443.1 407482294 13702402 complement(2836997..2838676) 1 NC_018658.1 COG0366 Glycosidases; putative glucosyltransferase 2838676 13702402 O3K_13785 Escherichia coli O104:H4 str. 2011C-3493 putative glucosyltransferase YP_006779443.1 2836997 R 1133852 CDS YP_006779444.1 407482295 13702403 complement(2838889..2839203) 1 NC_018658.1 COG0607 Rhodanese-related sulfurtransferase; thiosulfate:cyanide sulfurtransferase 2839203 13702403 O3K_13790 Escherichia coli O104:H4 str. 2011C-3493 thiosulfate:cyanide sulfurtransferase YP_006779444.1 2838889 R 1133852 CDS YP_006779445.1 407482296 13702404 complement(2839278..2839499) 1 NC_018658.1 peripheral inner membrane phage-shock protein 2839499 13702404 O3K_13795 Escherichia coli O104:H4 str. 2011C-3493 peripheral inner membrane phage-shock protein YP_006779445.1 2839278 R 1133852 CDS YP_006779446.1 407482297 13702405 complement(2839508..2839867) 1 NC_018658.1 COG1983 Putative stress-responsive transcriptional regulator; DNA-binding transcriptional activator PspC 2839867 13702405 O3K_13800 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional activator PspC YP_006779446.1 2839508 R 1133852 CDS YP_006779447.1 407482298 13702406 complement(2839867..2840091) 1 NC_018658.1 phage shock protein B 2840091 pspB 13702406 pspB Escherichia coli O104:H4 str. 2011C-3493 phage shock protein B YP_006779447.1 2839867 R 1133852 CDS YP_006779448.1 407482299 13702407 complement(2840145..2840813) 1 NC_018658.1 COG1842 Phage shock protein A (IM30), suppresses sigma54-dependent transcription; phage shock protein PspA 2840813 13702407 O3K_13810 Escherichia coli O104:H4 str. 2011C-3493 phage shock protein PspA YP_006779448.1 2840145 R 1133852 CDS YP_006779449.1 407482300 13702408 2840980..2841957 1 NC_018658.1 COG1221 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain; phage shock protein operon transcriptional activator 2841957 pspF 13702408 pspF Escherichia coli O104:H4 str. 2011C-3493 phage shock protein operon transcriptional activator YP_006779449.1 2840980 D 1133852 CDS YP_006779450.1 407482301 13702409 complement(2842077..2843342) 1 NC_018658.1 COG0160 4-aminobutyrate aminotransferase and related aminotransferases; 4-aminobutyrate transaminase 2843342 13702409 O3K_13820 Escherichia coli O104:H4 str. 2011C-3493 4-aminobutyrate transaminase YP_006779450.1 2842077 R 1133852 CDS YP_006779451.1 407482302 13702410 complement(2843380..2844660) 1 NC_018658.1 COG0665 Glycine/D-amino acid oxidases (deaminating); gamma-Glu-putrescine oxidase 2844660 13702410 O3K_13825 Escherichia coli O104:H4 str. 2011C-3493 gamma-Glu-putrescine oxidase YP_006779451.1 2843380 R 1133852 CDS YP_006779452.1 407482303 13702411 complement(2844662..2846149) 1 NC_018658.1 COG1012 NAD-dependent aldehyde dehydrogenases; gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase 2846149 13702411 O3K_13830 Escherichia coli O104:H4 str. 2011C-3493 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase YP_006779452.1 2844662 R 1133852 CDS YP_006779453.1 407482304 13702412 complement(2846424..2846981) 1 NC_018658.1 COG1396 Predicted transcriptional regulators; DNA-binding transcriptional repressor PuuR 2846981 13702412 O3K_13835 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional repressor PuuR YP_006779453.1 2846424 R 1133852 CDS YP_006779454.1 407482305 13702413 complement(2847008..2847772) 1 NC_018658.1 COG2071 Predicted glutamine amidotransferases; gamma-glutamyl-gamma-aminobutyrate hydrolase 2847772 puuD 13702413 puuD Escherichia coli O104:H4 str. 2011C-3493 gamma-glutamyl-gamma-aminobutyrate hydrolase YP_006779454.1 2847008 R 1133852 CDS YP_006779455.1 407482306 13702414 2847984..2849402 1 NC_018658.1 COG0174 Glutamine synthetase; gamma-glutamylputrescine synthetase 2849402 13702414 O3K_13845 Escherichia coli O104:H4 str. 2011C-3493 gamma-glutamylputrescine synthetase YP_006779455.1 2847984 D 1133852 CDS YP_006779456.1 407482307 13702415 2849705..2851090 1 NC_018658.1 COG0531 Amino acid transporters; putrescine importer 2851090 13702415 O3K_13850 Escherichia coli O104:H4 str. 2011C-3493 putrescine importer YP_006779456.1 2849705 D 1133852 CDS YP_006779457.1 407482308 13702416 2851224..2851469 1 NC_018658.1 hypothetical protein 2851469 13702416 O3K_13855 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779457.1 2851224 D 1133852 CDS YP_006779458.1 407482309 13702417 2851781..2853424 1 NC_018658.1 COG4166 ABC-type oligopeptide transport system, periplasmic component; antimicrobial peptide ABC transporter substrate-binding protein SapA 2853424 13702417 O3K_13860 Escherichia coli O104:H4 str. 2011C-3493 antimicrobial peptide ABC transporter substrate-binding protein SapA YP_006779458.1 2851781 D 1133852 CDS YP_006779459.1 407482310 13702418 2853421..2854386 1 NC_018658.1 COG4168 ABC-type antimicrobial peptide transport system, permease component; antimicrobial peptide ABC transporter permease SapB 2854386 13702418 O3K_13865 Escherichia coli O104:H4 str. 2011C-3493 antimicrobial peptide ABC transporter permease SapB YP_006779459.1 2853421 D 1133852 CDS YP_006779460.1 407482311 13702419 2854373..2855263 1 NC_018658.1 COG4171 ABC-type antimicrobial peptide transport system, permease component; antimicrobial peptide ABC transporter permease SapC 2855263 13702419 O3K_13870 Escherichia coli O104:H4 str. 2011C-3493 antimicrobial peptide ABC transporter permease SapC YP_006779460.1 2854373 D 1133852 CDS YP_006779461.1 407482312 13702420 2855263..2856255 1 NC_018658.1 COG4170 ABC-type antimicrobial peptide transport system, ATPase component; antimicrobial peptide ABC transporter ATP-binding protein 2856255 13702420 O3K_13875 Escherichia coli O104:H4 str. 2011C-3493 antimicrobial peptide ABC transporter ATP-binding protein YP_006779461.1 2855263 D 1133852 CDS YP_006779462.1 407482313 13702421 2856257..2857063 1 NC_018658.1 COG4167 ABC-type antimicrobial peptide transport system, ATPase component; antimicrobial peptide ABC transporter ATP-binding protein SapF 2857063 13702421 O3K_13880 Escherichia coli O104:H4 str. 2011C-3493 antimicrobial peptide ABC transporter ATP-binding protein SapF YP_006779462.1 2856257 D 1133852 CDS YP_006779463.1 407482314 13702422 2857131..2857484 1 NC_018658.1 COG2852 Uncharacterized protein conserved in bacteria; hypothetical protein 2857484 13702422 O3K_13885 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779463.1 2857131 D 1133852 CDS YP_006779464.1 407482315 13702423 2857854..2858642 1 NC_018658.1 COG0623 Enoyl-[acyl-carrier-protein] reductase (NADH); enoyl-ACP reductase 2858642 13702423 O3K_13890 Escherichia coli O104:H4 str. 2011C-3493 enoyl-ACP reductase YP_006779464.1 2857854 D 1133852 CDS YP_006779465.1 407482316 13702424 2858787..2859914 1 NC_018658.1 COG2128 Uncharacterized conserved protein; oxidoreductase 2859914 13702424 O3K_13895 Escherichia coli O104:H4 str. 2011C-3493 oxidoreductase YP_006779465.1 2858787 D 1133852 CDS YP_006779466.1 407482317 13702425 2859982..2861916 1 NC_018658.1 COG4776 Exoribonuclease II; exoribonuclease II 2861916 13702425 O3K_13900 Escherichia coli O104:H4 str. 2011C-3493 exoribonuclease II YP_006779466.1 2859982 D 1133852 CDS YP_006779467.1 407482318 13702426 complement(2861994..2862098) 1 NC_018658.1 hypothetical protein 2862098 13702426 O3K_13905 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779467.1 2861994 R 1133852 CDS YP_006779468.1 407482319 13702427 2862152..2864137 1 NC_018658.1 COG2199 FOG: GGDEF domain; RNase II stability modulator 2864137 13702427 O3K_13910 Escherichia coli O104:H4 str. 2011C-3493 RNase II stability modulator YP_006779468.1 2862152 D 1133852 CDS YP_006779469.1 407482320 13702428 2864284..2864457 1 NC_018658.1 hypothetical protein 2864457 13702428 O3K_13915 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779469.1 2864284 D 1133852 CDS YP_006779470.1 407482321 13702429 2864547..2865296 1 NC_018658.1 COG1349 Transcriptional regulators of sugar metabolism; DeoR family transcriptionel regulator 2865296 13702429 O3K_13920 Escherichia coli O104:H4 str. 2011C-3493 DeoR family transcriptionel regulator YP_006779470.1 2864547 D 1133852 CDS YP_006779471.1 407482322 13702430 2865565..2865783 1 NC_018658.1 lipoprotein 2865783 13702430 O3K_13925 Escherichia coli O104:H4 str. 2011C-3493 lipoprotein YP_006779471.1 2865565 D 1133852 CDS YP_006779472.1 407482323 13702431 complement(2865909..2866235) 1 NC_018658.1 COG0023 Translation initiation factor 1 (eIF-1/SUI1) and related proteins; translation initiation factor Sui1 2866235 13702431 O3K_13930 Escherichia coli O104:H4 str. 2011C-3493 translation initiation factor Sui1 YP_006779472.1 2865909 R 1133852 CDS YP_006779473.1 407482324 13702432 complement(2866235..2866972) 1 NC_018658.1 COG0284 Orotidine-5'-phosphate decarboxylase; orotidine 5'-phosphate decarboxylase 2866972 13702432 O3K_13935 Escherichia coli O104:H4 str. 2011C-3493 orotidine 5'-phosphate decarboxylase YP_006779473.1 2866235 R 1133852 CDS YP_006779474.1 407482325 13702433 complement(2867165..2868334) 1 NC_018658.1 COG2956 Predicted N-acetylglucosaminyl transferase; hypothetical protein 2868334 13702433 O3K_13940 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779474.1 2867165 R 1133852 CDS YP_006779475.1 407482326 13702434 complement(2868341..2868649) 1 NC_018658.1 COG3771 Predicted membrane protein; hypothetical protein 2868649 13702434 O3K_13945 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779475.1 2868341 R 1133852 CDS YP_006779476.1 407482327 13702435 complement(2868798..2869562) 1 NC_018658.1 COG0671 Membrane-associated phospholipid phosphatase; phosphatidylglycerophosphatase B 2869562 13702435 O3K_13950 Escherichia coli O104:H4 str. 2011C-3493 phosphatidylglycerophosphatase B YP_006779476.1 2868798 R 1133852 CDS YP_006779477.1 407482328 13702436 2869732..2870322 1 NC_018658.1 COG0807 GTP cyclohydrolase II; GTP cyclohydrolase II 2870322 ribA 13702436 ribA Escherichia coli O104:H4 str. 2011C-3493 GTP cyclohydrolase II YP_006779477.1 2869732 D 1133852 CDS YP_006779478.1 407482329 13702437 complement(2870386..2873061) 1 NC_018658.1 COG1048 Aconitase A; aconitate hydratase 2873061 13702437 O3K_13960 Escherichia coli O104:H4 str. 2011C-3493 aconitate hydratase YP_006779478.1 2870386 R 1133852 CDS YP_006779479.1 407482330 13702438 2873235..2873360 1 NC_018658.1 hypothetical protein 2873360 13702438 O3K_13965 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779479.1 2873235 D 1133852 CDS YP_006779480.1 407482331 13702439 complement(2873434..2873601) 1 NC_018658.1 hypothetical protein 2873601 13702439 O3K_13970 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779480.1 2873434 R 1133852 CDS YP_006779481.1 407482332 13702440 complement(2873604..2873732) 1 NC_018658.1 hypothetical protein 2873732 13702440 O3K_13975 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779481.1 2873604 R 1133852 CDS YP_006779482.1 407482333 13702441 complement(2874062..2875036) 1 NC_018658.1 COG0583 Transcriptional regulator; transcriptional regulator CysB 2875036 cysB 13702441 cysB Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator CysB YP_006779482.1 2874062 R 1133852 CDS YP_006779483.1 407482334 13702442 complement(2875246..2877843) 1 NC_018658.1 COG0550 Topoisomerase IA; DNA topoisomerase I subunit omega 2877843 13702442 O3K_13985 Escherichia coli O104:H4 str. 2011C-3493 DNA topoisomerase I subunit omega YP_006779483.1 2875246 R 1133852 CDS YP_006779484.1 407482335 13702443 2878223..2878474 1 NC_018658.1 hypothetical protein 2878474 13702443 O3K_13990 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779484.1 2878223 D 1133852 CDS YP_006779485.1 407482336 13702515 complement(2878510..2879559) 1 NC_018658.1 COG0616 Periplasmic serine proteases (ClpP class); putative inner membrane peptidase 2879559 13702515 O3K_13995 Escherichia coli O104:H4 str. 2011C-3493 putative inner membrane peptidase YP_006779485.1 2878510 R 1133852 CDS YP_006779486.1 407482337 13702516 2879779..2880537 1 NC_018658.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); putative oxoacyl-(acyl carrier protein) reductase 2880537 13702516 O3K_14000 Escherichia coli O104:H4 str. 2011C-3493 putative oxoacyl-(acyl carrier protein) reductase YP_006779486.1 2879779 D 1133852 CDS YP_006779487.1 407482338 13702517 2880534..2881124 1 NC_018658.1 COG2109 ATP:corrinoid adenosyltransferase; cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase 2881124 13702517 O3K_14005 Escherichia coli O104:H4 str. 2011C-3493 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase YP_006779487.1 2880534 D 1133852 CDS YP_006779488.1 407482339 13702518 complement(2881164..2882036) 1 NC_018658.1 COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases; 23S rRNA pseudouridylate synthase B 2882036 13702518 O3K_14010 Escherichia coli O104:H4 str. 2011C-3493 23S rRNA pseudouridylate synthase B YP_006779488.1 2881164 R 1133852 CDS YP_006779489.1 407482340 13702519 complement(2882137..2882757) 1 NC_018658.1 COG0009 Putative translation factor (SUA5); hypothetical protein 2882757 13702519 O3K_14015 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779489.1 2882137 R 1133852 CDS YP_006779490.1 407482341 13702520 complement(2882754..2883635) 1 NC_018658.1 COG0613 Predicted metal-dependent phosphoesterases (PHP family); hypothetical protein 2883635 13702520 O3K_14020 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779490.1 2882754 R 1133852 CDS YP_006779491.1 407482342 13702521 2883909..2885471 1 NC_018658.1 COG0147 Anthranilate/para-aminobenzoate synthases component I; anthranilate synthase component I 2885471 13702521 O3K_14025 Escherichia coli O104:H4 str. 2011C-3493 anthranilate synthase component I YP_006779491.1 2883909 D 1133852 CDS YP_006779492.1 407482343 13702522 2885471..2887066 1 NC_018658.1 COG0512 Anthranilate/para-aminobenzoate synthases component II; bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase 2887066 13702522 O3K_14030 Escherichia coli O104:H4 str. 2011C-3493 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase YP_006779492.1 2885471 D 1133852 CDS YP_006779493.1 407482344 13702523 2887070..2888428 1 NC_018658.1 COG0134 Indole-3-glycerol phosphate synthase; bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase 2888428 13702523 O3K_14035 Escherichia coli O104:H4 str. 2011C-3493 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase YP_006779493.1 2887070 D 1133852 CDS YP_006779494.1 407482345 13702524 2888440..2889633 1 NC_018658.1 COG0133 Tryptophan synthase beta chain; tryptophan synthase subunit beta 2889633 13702524 O3K_14040 Escherichia coli O104:H4 str. 2011C-3493 tryptophan synthase subunit beta YP_006779494.1 2888440 D 1133852 CDS YP_006779495.1 407482346 13702525 2889633..2890439 1 NC_018658.1 COG0159 Tryptophan synthase alpha chain; tryptophan synthase subunit alpha 2890439 trpA 13702525 trpA Escherichia coli O104:H4 str. 2011C-3493 tryptophan synthase subunit alpha YP_006779495.1 2889633 D 1133852 CDS YP_006779496.1 407482347 13702526 2891085..2891585 1 NC_018658.1 COG3685 Uncharacterized protein conserved in bacteria; YciF protein 2891585 13702526 O3K_14050 Escherichia coli O104:H4 str. 2011C-3493 YciF protein YP_006779496.1 2891085 D 1133852 CDS YP_006779497.1 407482348 13702527 2891631..2892137 1 NC_018658.1 COG3685 Uncharacterized protein conserved in bacteria; hypothetical protein 2892137 13702527 O3K_14055 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779497.1 2891631 D 1133852 CDS YP_006779498.1 407482349 13702528 complement(2892626..2892796) 1 NC_018658.1 tail component 2892796 13702528 O3K_14060 Escherichia coli O104:H4 str. 2011C-3493 tail component YP_006779498.1 2892626 R 1133852 CDS YP_006779499.1 407482350 13702529 complement(2892911..2893180) 1 NC_018658.1 tail fiber assembly protein 2893180 13702529 O3K_14065 Escherichia coli O104:H4 str. 2011C-3493 tail fiber assembly protein YP_006779499.1 2892911 R 1133852 CDS YP_006779500.1 407482351 13702530 2893249..2893905 1 NC_018658.1 COG0500 SAM-dependent methyltransferases; hypothetical protein 2893905 13702530 O3K_14070 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779500.1 2893249 D 1133852 CDS YP_006779501.1 407482352 13702531 complement(2893960..2894544) 1 NC_018658.1 putative tail fiber chaperone, Qin prophage 2894544 13702531 O3K_14075 Escherichia coli O104:H4 str. 2011C-3493 putative tail fiber chaperone, Qin prophage YP_006779501.1 2893960 R 1133852 CDS YP_006779502.1 407482353 13702532 complement(2894544..2897378) 1 NC_018658.1 putative phage tail fiber protein 2897378 13702532 O3K_14080 Escherichia coli O104:H4 str. 2011C-3493 putative phage tail fiber protein YP_006779502.1 2894544 R 1133852 CDS YP_006779503.1 407482354 13702533 complement(2897530..2898129) 1 NC_018658.1 putative outer membrane Lom 2898129 13702533 O3K_14085 Escherichia coli O104:H4 str. 2011C-3493 putative outer membrane Lom YP_006779503.1 2897530 R 1133852 CDS YP_006779504.1 407482355 13702534 complement(2898197..2901676) 1 NC_018658.1 COG4733 Phage-related protein, tail component; Host specificity protein J 2901676 13702534 O3K_14090 Escherichia coli O104:H4 str. 2011C-3493 Host specificity protein J YP_006779504.1 2898197 R 1133852 CDS YP_006779505.1 407482356 13702535 complement(2902155..2902796) 1 NC_018658.1 COG4723 Phage-related protein, tail component; Tail assembly protein I from prophage 2902796 13702535 O3K_14095 Escherichia coli O104:H4 str. 2011C-3493 Tail assembly protein I from prophage YP_006779505.1 2902155 R 1133852 CDS YP_006779506.1 407482357 13702536 complement(2902694..2903437) 1 NC_018658.1 COG1310 Predicted metal-dependent protease of the PAD1/JAB1 superfamily; tail fiber component K of prophage 2903437 13702536 O3K_14100 Escherichia coli O104:H4 str. 2011C-3493 tail fiber component K of prophage YP_006779506.1 2902694 R 1133852 CDS YP_006779507.1 407482358 13702537 complement(2903442..2904140) 1 NC_018658.1 COG4672 Phage-related protein; Minor tail protein L 2904140 13702537 O3K_14105 Escherichia coli O104:H4 str. 2011C-3493 Minor tail protein L YP_006779507.1 2903442 R 1133852 CDS YP_006779508.1 407482359 13702538 complement(2904140..2904469) 1 NC_018658.1 COG4718 Phage-related protein; minor tail protein M 2904469 13702538 O3K_14110 Escherichia coli O104:H4 str. 2011C-3493 minor tail protein M YP_006779508.1 2904140 R 1133852 CDS YP_006779509.1 407482360 13702539 complement(2904466..2907039) 1 NC_018658.1 COG5281 Phage-related minor tail protein; Minor tail protein precursor H 2907039 13702539 O3K_14115 Escherichia coli O104:H4 str. 2011C-3493 Minor tail protein precursor H YP_006779509.1 2904466 R 1133852 CDS YP_006779510.1 407482361 13702540 complement(2907020..2907433) 1 NC_018658.1 tail protein 2907433 13702540 O3K_14120 Escherichia coli O104:H4 str. 2011C-3493 tail protein YP_006779510.1 2907020 R 1133852 CDS YP_006779511.1 407482362 13702541 complement(2907460..2907891) 1 NC_018658.1 Minor tail protein G 2907891 13702541 O3K_14125 Escherichia coli O104:H4 str. 2011C-3493 Minor tail protein G YP_006779511.1 2907460 R 1133852 CDS YP_006779512.1 407482363 13702542 complement(2907905..2908567) 1 NC_018658.1 COG5492 Bacterial surface proteins containing Ig-like domains; tail protein 2908567 13702542 O3K_14130 Escherichia coli O104:H4 str. 2011C-3493 tail protein YP_006779512.1 2907905 R 1133852 CDS YP_006779513.1 407482364 13702543 complement(2908663..2909058) 1 NC_018658.1 putative minor tail protein 2909058 13702543 O3K_14135 Escherichia coli O104:H4 str. 2011C-3493 putative minor tail protein YP_006779513.1 2908663 R 1133852 CDS YP_006779514.1 407482365 13702544 complement(2909055..2909630) 1 NC_018658.1 Minor tail protein Z (GpZ) 2909630 13702544 O3K_14140 Escherichia coli O104:H4 str. 2011C-3493 Minor tail protein Z (GpZ) YP_006779514.1 2909055 R 1133852 CDS YP_006779515.1 407482366 13702545 complement(2909645..2909998) 1 NC_018658.1 Tail attachment protein (Minor capsid protein FII) 2909998 13702545 O3K_14145 Escherichia coli O104:H4 str. 2011C-3493 Tail attachment protein (Minor capsid protein FII) YP_006779515.1 2909645 R 1133852 CDS YP_006779516.1 407482367 13702546 complement(2909991..2910359) 1 NC_018658.1 putative DNA packaging protein from phage origin 2910359 13702546 O3K_14150 Escherichia coli O104:H4 str. 2011C-3493 putative DNA packaging protein from phage origin YP_006779516.1 2909991 R 1133852 CDS YP_006779517.1 407482368 13702547 complement(2910411..2911439) 1 NC_018658.1 major head protein 2911439 13702547 O3K_14155 Escherichia coli O104:H4 str. 2011C-3493 major head protein YP_006779517.1 2910411 R 1133852 CDS YP_006779518.1 407482369 13702548 complement(2911497..2911844) 1 NC_018658.1 putative head-DNA stabilization protein 2911844 13702548 O3K_14160 Escherichia coli O104:H4 str. 2011C-3493 putative head-DNA stabilization protein YP_006779518.1 2911497 R 1133852 CDS YP_006779519.1 407482370 13702549 complement(2911881..2913386) 1 NC_018658.1 COG0616 Periplasmic serine proteases (ClpP class); head-tail preconnector protein GP5 2913386 13702549 O3K_14165 Escherichia coli O104:H4 str. 2011C-3493 head-tail preconnector protein GP5 YP_006779519.1 2911881 R 1133852 CDS YP_006779520.1 407482371 13702550 complement(2913376..2914968) 1 NC_018658.1 COG5511 Bacteriophage capsid protein; head protein Gp4 2914968 13702550 O3K_14170 Escherichia coli O104:H4 str. 2011C-3493 head protein Gp4 YP_006779520.1 2913376 R 1133852 CDS YP_006779521.1 407482372 13702551 complement(2914965..2915171) 1 NC_018658.1 head completion protein 2915171 13702551 O3K_14175 Escherichia coli O104:H4 str. 2011C-3493 head completion protein YP_006779521.1 2914965 R 1133852 CDS YP_006779522.1 407482373 13702552 complement(2915155..2917083) 1 NC_018658.1 COG5525 Bacteriophage tail assembly protein; Terminase large subunit (Gp2) 2917083 13702552 O3K_14180 Escherichia coli O104:H4 str. 2011C-3493 Terminase large subunit (Gp2) YP_006779522.1 2915155 R 1133852 CDS YP_006779523.1 407482374 13702553 complement(2917055..2917603) 1 NC_018658.1 COG4220 Phage DNA packaging protein, Nu1 subunit of terminase; prophage Qin DNA packaging protein NU1-like protein 2917603 13702553 O3K_14185 Escherichia coli O104:H4 str. 2011C-3493 prophage Qin DNA packaging protein NU1-like protein YP_006779523.1 2917055 R 1133852 CDS YP_006779524.1 407482375 13702554 complement(2917685..2917957) 1 NC_018658.1 hypothetical protein 2917957 13702554 O3K_14190 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779524.1 2917685 R 1133852 CDS YP_006779525.1 407482376 13702555 complement(2918004..2918408) 1 NC_018658.1 hypothetical protein 2918408 13702555 O3K_14195 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779525.1 2918004 R 1133852 CDS YP_006779526.1 407482377 13702556 complement(2918544..2918768) 1 NC_018658.1 hypothetical protein 2918768 13702556 O3K_14200 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779526.1 2918544 R 1133852 CDS YP_006779527.1 407482378 13702557 complement(2918862..2919149) 1 NC_018658.1 hypothetical protein 2919149 13702557 O3K_14205 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779527.1 2918862 R 1133852 CDS YP_006779528.1 407482379 13702558 complement(2919228..2919371) 1 NC_018658.1 hypothetical protein 2919371 13702558 O3K_14210 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779528.1 2919228 R 1133852 CDS YP_006779529.1 407482380 13702559 complement(2919368..2919835) 1 NC_018658.1 endopeptidase 2919835 13702559 O3K_14215 Escherichia coli O104:H4 str. 2011C-3493 endopeptidase YP_006779529.1 2919368 R 1133852 CDS YP_006779530.1 407482381 13702560 complement(2919935..2920150) 1 NC_018658.1 hypothetical protein 2920150 13702560 O3K_14220 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779530.1 2919935 R 1133852 CDS YP_006779531.1 407482382 13702561 complement(2920188..2920400) 1 NC_018658.1 COG5178 U5 snRNP spliceosome subunit; hypothetical protein 2920400 13702561 O3K_14225 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779531.1 2920188 R 1133852 CDS YP_006779532.1 407482383 13702562 complement(2920478..2921011) 1 NC_018658.1 COG3772 Phage-related lysozyme (muraminidase); phage-related lysozyme (muraminidase) 2921011 13702562 O3K_14230 Escherichia coli O104:H4 str. 2011C-3493 phage-related lysozyme (muraminidase) YP_006779532.1 2920478 R 1133852 CDS YP_006779533.1 407482384 13702563 complement(2921054..2921860) 1 NC_018658.1 phage protein 2921860 13702563 O3K_14235 Escherichia coli O104:H4 str. 2011C-3493 phage protein YP_006779533.1 2921054 R 1133852 CDS YP_006779534.1 407482385 13702564 complement(2921865..2922080) 1 NC_018658.1 lysis protein S of prophage CP-933V 2922080 13702564 O3K_14240 Escherichia coli O104:H4 str. 2011C-3493 lysis protein S of prophage CP-933V YP_006779534.1 2921865 R 1133852 CDS YP_006779535.1 407482386 13702565 complement(2922231..2924084) 1 NC_018658.1 prophage protein 2924084 13702565 O3K_14245 Escherichia coli O104:H4 str. 2011C-3493 prophage protein YP_006779535.1 2922231 R 1133852 CDS YP_006779536.1 407482387 13702566 2924345..2924680 1 NC_018658.1 anti-adapter protein IraM 2924680 13702566 O3K_14250 Escherichia coli O104:H4 str. 2011C-3493 anti-adapter protein IraM YP_006779536.1 2924345 D 1133852 CDS YP_006779537.1 407482388 13702567 complement(2925128..2925406) 1 NC_018658.1 hypothetical protein 2925406 13702567 O3K_14255 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779537.1 2925128 R 1133852 CDS YP_006779538.1 407482389 13702571 complement(2925891..2926940) 1 NC_018658.1 COG0863 DNA modification methylase; DNA adenine methyltransferase ( DNA methylase) from phage origin 2926940 13702571 O3K_14260 Escherichia coli O104:H4 str. 2011C-3493 DNA adenine methyltransferase ( DNA methylase) from phage origin YP_006779538.1 2925891 R 1133852 CDS YP_006779539.1 407482390 13702572 complement(2927091..2927288) 1 NC_018658.1 hypothetical protein 2927288 13702572 O3K_14265 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779539.1 2927091 R 1133852 CDS YP_006779540.1 407482391 13702573 complement(2927515..2928336) 1 NC_018658.1 COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain; antitermination protein Q of prophage 2928336 13702573 O3K_14270 Escherichia coli O104:H4 str. 2011C-3493 antitermination protein Q of prophage YP_006779540.1 2927515 R 1133852 CDS YP_006779541.1 407482392 13702574 complement(2928333..2928707) 1 NC_018658.1 COG4570 Holliday junction resolvase; holliday junction resolvase 2928707 13702574 O3K_14275 Escherichia coli O104:H4 str. 2011C-3493 holliday junction resolvase YP_006779541.1 2928333 R 1133852 CDS YP_006779542.1 407482393 13702575 complement(2928720..2929766) 1 NC_018658.1 hypothetical protein 2929766 13702575 O3K_14280 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779542.1 2928720 R 1133852 CDS YP_006779543.1 407482394 13702576 2929987..2930166 1 NC_018658.1 hypothetical protein 2930166 13702576 O3K_14285 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779543.1 2929987 D 1133852 CDS YP_006779544.1 407482395 13702577 complement(2930208..2930420) 1 NC_018658.1 cell killing protein encoded within cryptic prophage CP-933M 2930420 13702577 O3K_14290 Escherichia coli O104:H4 str. 2011C-3493 cell killing protein encoded within cryptic prophage CP-933M YP_006779544.1 2930208 R 1133852 CDS YP_006779545.1 407482396 13702578 complement(2930601..2931287) 1 NC_018658.1 COG1636 Uncharacterized protein conserved in bacteria; hypothetical protein 2931287 13702578 O3K_14295 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779545.1 2930601 R 1133852 CDS YP_006779546.1 407482397 13702579 complement(2931441..2931866) 1 NC_018658.1 phage protein 2931866 13702579 O3K_14300 Escherichia coli O104:H4 str. 2011C-3493 phage protein YP_006779546.1 2931441 R 1133852 CDS YP_006779547.1 407482398 13702580 complement(2931907..2932869) 1 NC_018658.1 putative replication protein 2932869 13702580 O3K_14305 Escherichia coli O104:H4 str. 2011C-3493 putative replication protein YP_006779547.1 2931907 R 1133852 CDS YP_006779548.1 407482399 13702581 complement(2932892..2933317) 1 NC_018658.1 putative phage regulatory protein CII 2933317 13702581 O3K_14310 Escherichia coli O104:H4 str. 2011C-3493 putative phage regulatory protein CII YP_006779548.1 2932892 R 1133852 CDS YP_006779549.1 407482400 13702582 complement(2933314..2933568) 1 NC_018658.1 regulatory protein 2933568 13702582 O3K_14315 Escherichia coli O104:H4 str. 2011C-3493 regulatory protein YP_006779549.1 2933314 R 1133852 CDS YP_006779550.1 407482401 13702583 2933648..2934067 1 NC_018658.1 COG1396 Predicted transcriptional regulators; phage repressor protein CI 2934067 13702583 O3K_14320 Escherichia coli O104:H4 str. 2011C-3493 phage repressor protein CI YP_006779550.1 2933648 D 1133852 CDS YP_006779551.1 407482402 13700923 2934364..2934516 1 NC_018658.1 hypothetical protein 2934516 13700923 O3K_14325 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779551.1 2934364 D 1133852 CDS YP_006779552.1 407482403 13700924 2934528..2934866 1 NC_018658.1 hypothetical protein 2934866 13700924 O3K_14330 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779552.1 2934528 D 1133852 CDS YP_006779553.1 407482404 13700925 complement(2934855..2935049) 1 NC_018658.1 hypothetical protein 2935049 13700925 O3K_14335 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779553.1 2934855 R 1133852 CDS YP_006779554.1 407482405 13700926 2935616..2935804 1 NC_018658.1 regulator of cell division encoded by prophage 2935804 13700926 O3K_14340 Escherichia coli O104:H4 str. 2011C-3493 regulator of cell division encoded by prophage YP_006779554.1 2935616 D 1133852 CDS YP_006779555.1 407482406 13700927 2935801..2935992 1 NC_018658.1 hypothetical protein 2935992 13700927 O3K_14345 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779555.1 2935801 D 1133852 CDS YP_006779556.1 407482407 13700928 2936085..2938556 1 NC_018658.1 putative exonuclease from phage origin 2938556 13700928 O3K_14350 Escherichia coli O104:H4 str. 2011C-3493 putative exonuclease from phage origin YP_006779556.1 2936085 D 1133852 CDS YP_006779557.1 407482408 13700929 2938621..2938869 1 NC_018658.1 Excisionase 2938869 13700929 O3K_14355 Escherichia coli O104:H4 str. 2011C-3493 Excisionase YP_006779557.1 2938621 D 1133852 CDS YP_006779558.1 407482409 13700930 2938847..2939977 1 NC_018658.1 COG0582 Integrase; putative integrase 2939977 13700930 O3K_14360 Escherichia coli O104:H4 str. 2011C-3493 putative integrase YP_006779558.1 2938847 D 1133852 CDS YP_006779559.1 407482410 13700931 complement(2940023..2940661) 1 NC_018658.1 COG3047 Outer membrane protein W; outer membrane protein W 2940661 13700931 O3K_14365 Escherichia coli O104:H4 str. 2011C-3493 outer membrane protein W YP_006779559.1 2940023 R 1133852 CDS YP_006779560.1 407482411 13700932 2941018..2941761 1 NC_018658.1 hypothetical protein 2941761 13700932 O3K_14370 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779560.1 2941018 D 1133852 CDS YP_006779561.1 407482412 13700933 2941791..2942330 1 NC_018658.1 COG2917 Intracellular septation protein A; intracellular septation protein A 2942330 13700933 O3K_14375 Escherichia coli O104:H4 str. 2011C-3493 intracellular septation protein A YP_006779561.1 2941791 D 1133852 CDS YP_006779562.1 407482413 13700934 2942435..2942833 1 NC_018658.1 COG1607 Acyl-CoA hydrolase; acyl-CoA esterase 2942833 13700934 O3K_14380 Escherichia coli O104:H4 str. 2011C-3493 acyl-CoA esterase YP_006779562.1 2942435 D 1133852 CDS YP_006779563.1 407482414 13700935 complement(2942873..2943592) 1 NC_018658.1 COG0810 Periplasmic protein TonB, links inner and outer membranes; transporter 2943592 13700935 O3K_14385 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006779563.1 2942873 R 1133852 CDS YP_006779564.1 407482415 13700936 2943816..2944112 1 NC_018658.1 COG2350 Uncharacterized protein conserved in bacteria; YciI-like protein 2944112 13700936 O3K_14390 Escherichia coli O104:H4 str. 2011C-3493 YciI-like protein YP_006779564.1 2943816 D 1133852 CDS YP_006779565.1 407482416 13700937 2944412..2945665 1 NC_018658.1 COG1226 Kef-type K+ transport systems, predicted NAD-binding component; voltage-gated potassium channel 2945665 13700937 O3K_14395 Escherichia coli O104:H4 str. 2011C-3493 voltage-gated potassium channel YP_006779565.1 2944412 D 1133852 CDS YP_006779566.1 407482417 13700938 2946036..2947496 1 NC_018658.1 COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipi n synthases and related enzymes; cardiolipin synthetase 2947496 cls 13700938 cls Escherichia coli O104:H4 str. 2011C-3493 cardiolipin synthetase YP_006779566.1 2946036 D 1133852 CDS YP_006779567.1 407482418 13700939 2947531..2947860 1 NC_018658.1 COG3099 Uncharacterized protein conserved in bacteria; dsDNA-mimic protein 2947860 13700939 O3K_14405 Escherichia coli O104:H4 str. 2011C-3493 dsDNA-mimic protein YP_006779567.1 2947531 D 1133852 CDS YP_006779568.1 407482419 13700940 complement(2947913..2948917) 1 NC_018658.1 COG4608 ABC-type oligopeptide transport system, ATPase component; oligopeptide ABC transporter ATP-binding protein OppF 2948917 13700940 O3K_14410 Escherichia coli O104:H4 str. 2011C-3493 oligopeptide ABC transporter ATP-binding protein OppF YP_006779568.1 2947913 R 1133852 CDS YP_006779569.1 407482420 13700941 complement(2948914..2949927) 1 NC_018658.1 COG0444 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component; oligopeptide ABC transporter ATP-binding protein 2949927 oppD 13700941 oppD Escherichia coli O104:H4 str. 2011C-3493 oligopeptide ABC transporter ATP-binding protein YP_006779569.1 2948914 R 1133852 CDS YP_006779570.1 407482421 13700942 complement(2949939..2950847) 1 NC_018658.1 COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; oligopeptide ABC transporter permease OppC 2950847 13700942 O3K_14420 Escherichia coli O104:H4 str. 2011C-3493 oligopeptide ABC transporter permease OppC YP_006779570.1 2949939 R 1133852 CDS YP_006779571.1 407482422 13700943 complement(2950862..2951782) 1 NC_018658.1 COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; oligopeptide transporter permease 2951782 oppB 13700943 oppB Escherichia coli O104:H4 str. 2011C-3493 oligopeptide transporter permease YP_006779571.1 2950862 R 1133852 CDS YP_006779572.1 407482423 13700944 complement(2951868..2953499) 1 NC_018658.1 COG4166 ABC-type oligopeptide transport system, periplasmic component; oligopeptide ABC transporter substrate-binding protein OppA 2953499 13700944 O3K_14430 Escherichia coli O104:H4 str. 2011C-3493 oligopeptide ABC transporter substrate-binding protein OppA YP_006779572.1 2951868 R 1133852 CDS YP_006779573.1 407482424 13700945 complement(2954237..2954884) 1 NC_018658.1 COG2095 Multiple antibiotic transporter; hypothetical protein 2954884 13700945 O3K_14435 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779573.1 2954237 R 1133852 CDS YP_006779574.1 407482425 13700946 2955361..2958036 1 NC_018658.1 COG1012 NAD-dependent aldehyde dehydrogenases; bifunctional acetaldehyde-CoA/alcohol dehydrogenase 2958036 13700946 O3K_14440 Escherichia coli O104:H4 str. 2011C-3493 bifunctional acetaldehyde-CoA/alcohol dehydrogenase YP_006779574.1 2955361 D 1133852 CDS YP_006779575.1 407482426 13700947 complement(2959342..2959959) 1 NC_018658.1 COG1435 Thymidine kinase; thymidine kinase 2959959 13700947 O3K_14460 Escherichia coli O104:H4 str. 2011C-3493 thymidine kinase YP_006779575.1 2959342 R 1133852 CDS YP_006779576.1 407482427 13700948 2960565..2960978 1 NC_018658.1 COG2916 DNA-binding protein H-NS; global DNA-binding transcriptional dual regulator H-NS 2960978 13700948 O3K_14465 Escherichia coli O104:H4 str. 2011C-3493 global DNA-binding transcriptional dual regulator H-NS YP_006779576.1 2960565 D 1133852 CDS YP_006779577.1 407482428 13700949 complement(2961122..2962030) 1 NC_018658.1 COG1210 UDP-glucose pyrophosphorylase; UTP--glucose-1-phosphate uridylyltransferase subunit GalU 2962030 13700949 O3K_14470 Escherichia coli O104:H4 str. 2011C-3493 UTP--glucose-1-phosphate uridylyltransferase subunit GalU YP_006779577.1 2961122 R 1133852 CDS YP_006779578.1 407482429 13700950 complement(2962232..2963245) 1 NC_018658.1 COG0784 FOG: CheY-like receiver; response regulator of RpoS 2963245 13700950 O3K_14475 Escherichia coli O104:H4 str. 2011C-3493 response regulator of RpoS YP_006779578.1 2962232 R 1133852 CDS YP_006779579.1 407482430 13700951 complement(2963337..2964242) 1 NC_018658.1 COG1752 Predicted esterase of the alpha-beta hydrolase superfamily; hypothetical protein 2964242 13700951 O3K_14480 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779579.1 2963337 R 1133852 CDS YP_006779580.1 407482431 13700952 2964355..2964813 1 NC_018658.1 COG3012 Uncharacterized protein conserved in bacteria; hypothetical protein 2964813 13700952 O3K_14485 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779580.1 2964355 D 1133852 CDS YP_006779581.1 407482432 13700953 2964863..2965705 1 NC_018658.1 COG0788 Formyltetrahydrofolate hydrolase; formyltetrahydrofolate deformylase 2965705 purU 13700953 purU Escherichia coli O104:H4 str. 2011C-3493 formyltetrahydrofolate deformylase YP_006779581.1 2964863 D 1133852 CDS YP_006779582.1 407482433 13700957 complement(2966430..2967107) 1 NC_018658.1 COG2181 Nitrate reductase gamma subunit; Respiratory nitrate reductase subunit gamma 2967107 13700957 O3K_14505 Escherichia coli O104:H4 str. 2011C-3493 Respiratory nitrate reductase subunit gamma YP_006779582.1 2966430 R 1133852 CDS YP_006779583.1 407482434 13700958 complement(2967107..2967817) 1 NC_018658.1 COG2180 Nitrate reductase delta subunit; molybdenum-cofactor-assembly chaperone subunit delta 2967817 13700958 O3K_14510 Escherichia coli O104:H4 str. 2011C-3493 molybdenum-cofactor-assembly chaperone subunit delta YP_006779583.1 2967107 R 1133852 CDS YP_006779584.1 407482435 13700959 complement(2967814..2969352) 1 NC_018658.1 COG1140 Nitrate reductase beta subunit; nitrate reductase subunit beta 2969352 13700959 O3K_14515 Escherichia coli O104:H4 str. 2011C-3493 nitrate reductase subunit beta YP_006779584.1 2967814 R 1133852 CDS YP_006779585.1 407482436 13700960 complement(2969349..2973092) 1 NC_018658.1 COG5013 Nitrate reductase alpha subunit; nitrate reductase subunit alpha 2973092 13700960 O3K_14520 Escherichia coli O104:H4 str. 2011C-3493 nitrate reductase subunit alpha YP_006779585.1 2969349 R 1133852 CDS YP_006779586.1 407482437 13700961 complement(2973608..2974999) 1 NC_018658.1 COG2223 Nitrate/nitrite transporter; nitrite extrusion protein 2974999 13700961 O3K_14525 Escherichia coli O104:H4 str. 2011C-3493 nitrite extrusion protein YP_006779586.1 2973608 R 1133852 CDS YP_006779587.1 407482438 13700962 2975338..2977134 1 NC_018658.1 COG3850 Signal transduction histidine kinase, nitrate/nitrite-specific; nitrate/nitrite sensor protein NarX 2977134 13700962 O3K_14530 Escherichia coli O104:H4 str. 2011C-3493 nitrate/nitrite sensor protein NarX YP_006779587.1 2975338 D 1133852 CDS YP_006779588.1 407482439 13700963 2977127..2977777 1 NC_018658.1 DNA-binding transcriptional regulator; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; nitrate/nitrite response regulator protein NarL 2977777 13700963 O3K_14535 Escherichia coli O104:H4 str. 2011C-3493 nitrate/nitrite response regulator protein NarL YP_006779588.1 2977127 D 1133852 CDS YP_006779589.1 407482440 13700964 complement(2977778..2979031) 1 NC_018658.1 putative invasin 2979031 13700964 O3K_14540 Escherichia coli O104:H4 str. 2011C-3493 putative invasin YP_006779589.1 2977778 R 1133852 CDS YP_006779590.1 407482441 13700965 2979357..2979710 1 NC_018658.1 COG1553 Uncharacterized conserved protein involved in intracellular sulfur reduction; hypothetical protein 2979710 13700965 O3K_14545 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779590.1 2979357 D 1133852 CDS YP_006779591.1 407482442 13700966 complement(2979754..2980470) 1 NC_018658.1 COG3703 Uncharacterized protein involved in cation transport; regulatory protein for cation transport 2980470 13700966 O3K_14550 Escherichia coli O104:H4 str. 2011C-3493 regulatory protein for cation transport YP_006779591.1 2979754 R 1133852 CDS YP_006779592.1 407482443 13700967 complement(2980607..2980837) 1 NC_018658.1 COG4572 Putative cation transport regulator; cation transport regulator 2980837 chaB 13700967 chaB Escherichia coli O104:H4 str. 2011C-3493 cation transport regulator YP_006779592.1 2980607 R 1133852 CDS YP_006779593.1 407482444 13700968 2981107..2982207 1 NC_018658.1 COG0387 Ca2+/H+ antiporter; calcium/sodium:proton antiporter 2982207 13700968 O3K_14560 Escherichia coli O104:H4 str. 2011C-3493 calcium/sodium:proton antiporter YP_006779593.1 2981107 D 1133852 CDS YP_006779594.1 407482445 13700969 2982612..2982719 1 NC_018658.1 hypothetical protein 2982719 13700969 O3K_14565 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779594.1 2982612 D 1133852 CDS YP_006779595.1 407482446 13700970 2983148..2983255 1 NC_018658.1 small toxic polypeptide 2983255 13700970 O3K_14570 Escherichia coli O104:H4 str. 2011C-3493 small toxic polypeptide YP_006779595.1 2983148 D 1133852 CDS YP_006779596.1 407482447 13700971 2983683..2983790 1 NC_018658.1 hypothetical protein 2983790 13700971 O3K_14575 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779596.1 2983683 D 1133852 CDS YP_006779597.1 407482448 13700972 complement(2983939..2984793) 1 NC_018658.1 COG2877 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase; 2-dehydro-3-deoxyphosphooctonate aldolase 2984793 13700972 O3K_14580 Escherichia coli O104:H4 str. 2011C-3493 2-dehydro-3-deoxyphosphooctonate aldolase YP_006779597.1 2983939 R 1133852 CDS YP_006779598.1 407482449 13700973 complement(2984829..2985638) 1 NC_018658.1 COG2912 Uncharacterized conserved protein; hypothetical protein 2985638 13700973 O3K_14585 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779598.1 2984829 R 1133852 CDS YP_006779599.1 407482450 13700974 complement(2985642..2986034) 1 NC_018658.1 COG3094 Uncharacterized protein conserved in bacteria; hypothetical protein 2986034 13700974 O3K_14590 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779599.1 2985642 R 1133852 CDS YP_006779600.1 407482451 13700975 complement(2986031..2986864) 1 NC_018658.1 COG2890 Methylase of polypeptide chain release factors; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 2986864 13700975 O3K_14595 Escherichia coli O104:H4 str. 2011C-3493 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase YP_006779600.1 2986031 R 1133852 CDS YP_006779601.1 407482452 13700976 complement(2986864..2987946) 1 NC_018658.1 COG0216 Protein chain release factor A; peptide chain release factor 1 2987946 prfA 13700976 prfA Escherichia coli O104:H4 str. 2011C-3493 peptide chain release factor 1 YP_006779601.1 2986864 R 1133852 CDS YP_006779602.1 407482453 13700977 complement(2987988..2989244) 1 NC_018658.1 COG0373 Glutamyl-tRNA reductase; glutamyl-tRNA reductase 2989244 hemA 13700977 hemA Escherichia coli O104:H4 str. 2011C-3493 glutamyl-tRNA reductase YP_006779602.1 2987988 R 1133852 CDS YP_006779603.1 407482454 13700978 2989458..2990081 1 NC_018658.1 COG3017 Outer membrane lipoprotein involved in outer membrane biogenesis; outer membrane lipoprotein LolB 2990081 lolB 13700978 lolB Escherichia coli O104:H4 str. 2011C-3493 outer membrane lipoprotein LolB YP_006779603.1 2989458 D 1133852 CDS YP_006779604.1 407482455 13700979 2990081..2990932 1 NC_018658.1 COG1947 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 2990932 ipk 13700979 ipk Escherichia coli O104:H4 str. 2011C-3493 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase YP_006779604.1 2990081 D 1133852 CDS YP_006779605.1 407482456 13700980 2991083..2992030 1 NC_018658.1 COG0462 Phosphoribosylpyrophosphate synthetase; ribose-phosphate pyrophosphokinase 2992030 13700980 O3K_14620 Escherichia coli O104:H4 str. 2011C-3493 ribose-phosphate pyrophosphokinase YP_006779605.1 2991083 D 1133852 CDS YP_006779606.1 407482457 13700981 2992155..2993834 1 NC_018658.1 COG0659 Sulfate permease and related transporters (MFS superfamily); transporter 2993834 13700981 O3K_14625 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006779606.1 2992155 D 1133852 CDS YP_006779607.1 407482458 13700982 complement(2993889..2994167) 1 NC_018658.1 hypothetical protein 2994167 13700982 O3K_14630 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779607.1 2993889 R 1133852 CDS YP_006779608.1 407482459 13700983 2994445..2995029 1 NC_018658.1 COG0193 Peptidyl-tRNA hydrolase; peptidyl-tRNA hydrolase 2995029 13700983 O3K_14635 Escherichia coli O104:H4 str. 2011C-3493 peptidyl-tRNA hydrolase YP_006779608.1 2994445 D 1133852 CDS YP_006779609.1 407482460 13700984 2995146..2996237 1 NC_018658.1 COG0012 Predicted GTPase, probable translation factor; GTP-binding protein YchF 2996237 13700984 O3K_14640 Escherichia coli O104:H4 str. 2011C-3493 GTP-binding protein YchF YP_006779609.1 2995146 D 1133852 CDS YP_006779610.1 407482461 13700985 complement(2996482..2996661) 1 NC_018658.1 hypothetical protein 2996661 13700985 O3K_14645 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779610.1 2996482 R 1133852 CDS YP_006779611.1 407482462 13700986 2997006..2999873 1 NC_018658.1 COG3468 Type V secretory pathway, adhesin AidA; adhesin, autotransporter 2999873 13700986 O3K_14650 Escherichia coli O104:H4 str. 2011C-3493 adhesin, autotransporter YP_006779611.1 2997006 D 1133852 CDS YP_006779612.1 407482463 13700987 complement(2999973..3001892) 1 NC_018658.1 COG3284 Transcriptional activator of acetoin/glycerol metabolism; DNA-binding transcriptional regulator DhaR 3001892 13700987 O3K_14655 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator DhaR YP_006779612.1 2999973 R 1133852 CDS YP_006779613.1 407482464 13700988 3002120..3003190 1 NC_018658.1 COG2376 Dihydroxyacetone kinase; dihydroxyacetone kinase subunit DhaK 3003190 13700988 O3K_14660 Escherichia coli O104:H4 str. 2011C-3493 dihydroxyacetone kinase subunit DhaK YP_006779613.1 3002120 D 1133852 CDS YP_006779614.1 407482465 13700989 3003201..3003833 1 NC_018658.1 COG2376 Dihydroxyacetone kinase; dihydroxyacetone kinase subunit DhaL 3003833 13700989 O3K_14665 Escherichia coli O104:H4 str. 2011C-3493 dihydroxyacetone kinase subunit DhaL YP_006779614.1 3003201 D 1133852 CDS YP_006779615.1 407482466 13700990 3003844..3005262 1 NC_018658.1 COG3412 Uncharacterized protein conserved in bacteria; dihydroxyacetone kinase subunit DhaM 3005262 13700990 O3K_14670 Escherichia coli O104:H4 str. 2011C-3493 dihydroxyacetone kinase subunit DhaM YP_006779615.1 3003844 D 1133852 CDS YP_006779616.1 407482467 13700991 3005582..3007279 1 NC_018658.1 COG1626 Neutral trehalase; trehalase 3007279 treA 13700991 treA Escherichia coli O104:H4 str. 2011C-3493 trehalase YP_006779616.1 3005582 D 1133852 CDS YP_006779617.1 407482468 13700992 complement(3007358..3007798) 1 NC_018658.1 hypothetical protein 3007798 13700992 O3K_14680 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779617.1 3007358 R 1133852 CDS YP_006779618.1 407482469 13700993 complement(3007976..3008230) 1 NC_018658.1 COG2261 Predicted membrane protein; transglycosylase-associated protein 3008230 13700993 O3K_14685 Escherichia coli O104:H4 str. 2011C-3493 transglycosylase-associated protein YP_006779618.1 3007976 R 1133852 CDS YP_006779619.1 407482470 13700994 3008431..3009165 1 NC_018658.1 COG5581 Predicted glycosyltransferase; flagellar function protein 3009165 13700994 O3K_14690 Escherichia coli O104:H4 str. 2011C-3493 flagellar function protein YP_006779619.1 3008431 D 1133852 CDS YP_006779620.1 407482471 13700995 complement(3009167..3009778) 1 NC_018658.1 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains); lytic murein endotransglycosylase E 3009778 emtA 13700995 emtA Escherichia coli O104:H4 str. 2011C-3493 lytic murein endotransglycosylase E YP_006779620.1 3009167 R 1133852 CDS YP_006779621.1 407482472 13700996 3009878..3010792 1 NC_018658.1 COG1619 Uncharacterized proteins, homologs of microcin C7 resistance protein MccF; L,D-carboxypeptidase A 3010792 ldcA 13700996 ldcA Escherichia coli O104:H4 str. 2011C-3493 L,D-carboxypeptidase A YP_006779621.1 3009878 D 1133852 CDS YP_006779622.1 407482473 13700997 3010887..3012623 1 NC_018658.1 COG3263 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain; potassium/proton antiporter 3012623 13700997 O3K_14705 Escherichia coli O104:H4 str. 2011C-3493 potassium/proton antiporter YP_006779622.1 3010887 D 1133852 CDS YP_006779623.1 407482474 13700998 complement(3013009..3014079) 1 NC_018658.1 COG0787 Alanine racemase; alanine racemase 3014079 dadX 13700998 dadX Escherichia coli O104:H4 str. 2011C-3493 alanine racemase YP_006779623.1 3013009 R 1133852 CDS YP_006779624.1 407482475 13700999 complement(3014089..3015387) 1 NC_018658.1 COG0665 Glycine/D-amino acid oxidases (deaminating); D-amino acid dehydrogenase small subunit 3015387 13700999 O3K_14715 Escherichia coli O104:H4 str. 2011C-3493 D-amino acid dehydrogenase small subunit YP_006779624.1 3014089 R 1133852 CDS YP_006779625.1 407482476 13701000 3015717..3017249 1 NC_018658.1 COG2719 Uncharacterized conserved protein; SpoVR family protein 3017249 13701000 O3K_14720 Escherichia coli O104:H4 str. 2011C-3493 SpoVR family protein YP_006779625.1 3015717 D 1133852 CDS YP_006779626.1 407482477 13701001 complement(3017301..3018020) 1 NC_018658.1 COG2186 Transcriptional regulators; fatty acid metabolism regulator 3018020 13701001 O3K_14725 Escherichia coli O104:H4 str. 2011C-3493 fatty acid metabolism regulator YP_006779626.1 3017301 R 1133852 CDS YP_006779627.1 407482478 13701002 3018242..3019783 1 NC_018658.1 COG3067 Na+/H+ antiporter; sodium/proton antiporter 3019783 nhaB 13701002 nhaB Escherichia coli O104:H4 str. 2011C-3493 sodium/proton antiporter YP_006779627.1 3018242 D 1133852 CDS YP_006779628.1 407482479 13701003 3019929..3020459 1 NC_018658.1 COG1495 Disulfide bond formation protein DsbB; disulfide bond formation protein B 3020459 13701003 O3K_14735 Escherichia coli O104:H4 str. 2011C-3493 disulfide bond formation protein B YP_006779628.1 3019929 D 1133852 CDS YP_006779629.1 407482480 13701004 complement(3020505..3021773) 1 NC_018658.1 COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair; DNA polymerase V subunit UmuC 3021773 umuC 13701004 umuC Escherichia coli O104:H4 str. 2011C-3493 DNA polymerase V subunit UmuC YP_006779629.1 3020505 R 1133852 CDS YP_006779630.1 407482481 13701005 complement(3021773..3022192) 1 NC_018658.1 COG1974 SOS-response transcriptional repressors (RecA-mediated autopeptidases); DNA polymerase V subunit UmuD 3022192 13701005 O3K_14745 Escherichia coli O104:H4 str. 2011C-3493 DNA polymerase V subunit UmuD YP_006779630.1 3021773 R 1133852 CDS YP_006779631.1 407482482 13701006 3023194..3023475 1 NC_018658.1 hemolysin E 3023475 hlyE 13701006 hlyE Escherichia coli O104:H4 str. 2011C-3493 hemolysin E YP_006779631.1 3023194 D 1133852 CDS YP_006779632.1 407482483 13701007 complement(3023682..3024128) 1 NC_018658.1 COG2983 Uncharacterized conserved protein; hypothetical protein 3024128 13701007 O3K_14765 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779632.1 3023682 R 1133852 CDS YP_006779633.1 407482484 13701008 complement(3024220..3024879) 1 NC_018658.1 COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway); hypothetical protein 3024879 13701008 O3K_14770 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779633.1 3024220 R 1133852 CDS YP_006779634.1 407482485 13701009 complement(3024951..3025277) 1 NC_018658.1 COG3100 Uncharacterized protein conserved in bacteria; hypothetical protein 3025277 13701009 O3K_14775 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779634.1 3024951 R 1133852 CDS YP_006779635.1 407482486 13701010 3025486..3025887 1 NC_018658.1 hypothetical protein 3025887 13701010 O3K_14780 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779635.1 3025486 D 1133852 CDS YP_006779636.1 407482487 13701011 complement(3026007..3026375) 1 NC_018658.1 hypothetical protein 3026375 13701011 O3K_14785 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779636.1 3026007 R 1133852 CDS YP_006779637.1 407482488 13701012 3026895..3027590 1 NC_018658.1 COG0850 Septum formation inhibitor; septum formation inhibitor 3027590 minC 13701012 minC Escherichia coli O104:H4 str. 2011C-3493 septum formation inhibitor YP_006779637.1 3026895 D 1133852 CDS YP_006779638.1 407482489 13701013 3027614..3028426 1 NC_018658.1 COG2894 Septum formation inhibitor-activating ATPase; cell division inhibitor MinD 3028426 13701013 O3K_14795 Escherichia coli O104:H4 str. 2011C-3493 cell division inhibitor MinD YP_006779638.1 3027614 D 1133852 CDS YP_006779639.1 407482490 13701014 3028430..3028696 1 NC_018658.1 COG0851 Septum formation topological specificity factor; cell division topological specificity factor MinE 3028696 minE 13701014 minE Escherichia coli O104:H4 str. 2011C-3493 cell division topological specificity factor MinE YP_006779639.1 3028430 D 1133852 CDS YP_006779640.1 407482491 13701015 complement(3029068..3029280) 1 NC_018658.1 adhesin 3029280 13701015 O3K_14805 Escherichia coli O104:H4 str. 2011C-3493 adhesin YP_006779640.1 3029068 R 1133852 CDS YP_006779641.1 407482492 13701016 3030048..3030332 1 NC_018658.1 hypothetical protein 3030332 13701016 O3K_14810 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779641.1 3030048 D 1133852 CDS YP_006779642.1 407482493 13701017 3030342..3030671 1 NC_018658.1 hypothetical protein 3030671 13701017 O3K_14815 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779642.1 3030342 D 1133852 CDS YP_006779643.1 407482494 13701018 complement(3030728..3033049) 1 NC_018658.1 COG3468 Type V secretory pathway, adhesin AidA; putative autotransporter 3033049 13701018 O3K_14820 Escherichia coli O104:H4 str. 2011C-3493 putative autotransporter YP_006779643.1 3030728 R 1133852 CDS YP_006779644.1 407482495 13701019 complement(3033166..3033375) 1 NC_018658.1 hypothetical protein 3033375 13701019 O3K_14825 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779644.1 3033166 R 1133852 CDS YP_006779645.1 407482496 13701020 complement(3033775..3033993) 1 NC_018658.1 hypothetical protein 3033993 13701020 O3K_14830 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779645.1 3033775 R 1133852 CDS YP_006779646.1 407482497 13701021 complement(3034125..3035648) 1 NC_018658.1 COG2200 FOG: EAL domain; hypothetical protein 3035648 13701021 O3K_14835 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779646.1 3034125 R 1133852 CDS YP_006779647.1 407482498 13701022 complement(3035980..3036228) 1 NC_018658.1 hypothetical protein 3036228 13701022 O3K_14840 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779647.1 3035980 R 1133852 CDS YP_006779648.1 407482499 13701023 complement(3036341..3036607) 1 NC_018658.1 hypothetical protein 3036607 13701023 O3K_14845 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779648.1 3036341 R 1133852 CDS YP_006779649.1 407482500 13701024 complement(3036636..3036908) 1 NC_018658.1 hypothetical protein 3036908 13701024 O3K_14850 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779649.1 3036636 R 1133852 CDS YP_006779650.1 407482501 13701025 complement(3036951..3037187) 1 NC_018658.1 hypothetical protein 3037187 13701025 O3K_14855 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779650.1 3036951 R 1133852 CDS YP_006779651.1 407482502 13701026 3037501..3038712 1 NC_018658.1 COG2200 FOG: EAL domain; cyclic-di-GMP phosphodiesterase, blue-light sensing protein using FAD (BLUF) 3038712 13701026 O3K_14860 Escherichia coli O104:H4 str. 2011C-3493 cyclic-di-GMP phosphodiesterase, blue-light sensing protein using FAD (BLUF) YP_006779651.1 3037501 D 1133852 CDS YP_006779652.1 407482503 13701027 3038917..3039648 1 NC_018658.1 COG0789 Predicted transcriptional regulators; putative DNA-binding transcriptional regulator 3039648 13701027 O3K_14865 Escherichia coli O104:H4 str. 2011C-3493 putative DNA-binding transcriptional regulator YP_006779652.1 3038917 D 1133852 CDS YP_006779653.1 407482504 13701028 3039869..3040273 1 NC_018658.1 COG5562 Phage envelope protein; hypothetical protein 3040273 13701028 O3K_14870 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779653.1 3039869 D 1133852 CDS YP_006779654.1 407482505 13701029 3040969..3041292 1 NC_018658.1 anti-adapter protein IraM 3041292 13701029 O3K_14875 Escherichia coli O104:H4 str. 2011C-3493 anti-adapter protein IraM YP_006779654.1 3040969 D 1133852 CDS YP_006779655.1 407482506 13701030 complement(3041395..3042645) 1 NC_018658.1 COG0538 Isocitrate dehydrogenases; isocitrate dehydrogenase 3042645 13701030 O3K_14880 Escherichia coli O104:H4 str. 2011C-3493 isocitrate dehydrogenase YP_006779655.1 3041395 R 1133852 CDS YP_006779656.1 407482507 13701031 3042817..3043470 1 NC_018658.1 COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases; 23S rRNA pseudouridine synthase E 3043470 13701031 O3K_14885 Escherichia coli O104:H4 str. 2011C-3493 23S rRNA pseudouridine synthase E YP_006779656.1 3042817 D 1133852 CDS YP_006779657.1 407482508 13701032 3043480..3043941 1 NC_018658.1 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; bifunctional thiamin pyrimidine pyrophosphate hydrolase/thiamin pyrophosphate hydrolase 3043941 13701032 O3K_14890 Escherichia coli O104:H4 str. 2011C-3493 bifunctional thiamin pyrimidine pyrophosphate hydrolase/thiamin pyrophosphate hydrolase YP_006779657.1 3043480 D 1133852 CDS YP_006779658.1 407482509 13701033 3043995..3045101 1 NC_018658.1 COG0482 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain; tRNA-specific 2-thiouridylase MnmA 3045101 mnmA 13701033 mnmA Escherichia coli O104:H4 str. 2011C-3493 tRNA-specific 2-thiouridylase MnmA YP_006779658.1 3043995 D 1133852 CDS YP_006779659.1 407482510 13701034 3045137..3045778 1 NC_018658.1 COG2915 Uncharacterized protein involved in purine metabolism; putative lysogenization regulator 3045778 13701034 O3K_14900 Escherichia coli O104:H4 str. 2011C-3493 putative lysogenization regulator YP_006779659.1 3045137 D 1133852 CDS YP_006779660.1 407482511 13701035 3045782..3047152 1 NC_018658.1 COG0015 Adenylosuccinate lyase; adenylosuccinate lyase 3047152 13701035 O3K_14905 Escherichia coli O104:H4 str. 2011C-3493 adenylosuccinate lyase YP_006779660.1 3045782 D 1133852 CDS YP_006779661.1 407482512 13701036 3047320..3047991 1 NC_018658.1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; DNA-binding transcriptional regulator PhoP 3047991 13701036 O3K_14910 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator PhoP YP_006779661.1 3047320 D 1133852 CDS YP_006779662.1 407482513 13701037 3047991..3049451 1 NC_018658.1 COG0642 Signal transduction histidine kinase; sensor protein PhoQ 3049451 13701037 O3K_14915 Escherichia coli O104:H4 str. 2011C-3493 sensor protein PhoQ YP_006779662.1 3047991 D 1133852 CDS YP_006779663.1 407482514 13701038 3049527..3050648 1 NC_018658.1 COG2850 Uncharacterized conserved protein; hypothetical protein 3050648 13701038 O3K_14920 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779663.1 3049527 D 1133852 CDS YP_006779664.1 407482515 13701039 complement(3050794..3052023) 1 NC_018658.1 COG2195 Di- and tripeptidases; peptidase T 3052023 13701039 O3K_14925 Escherichia coli O104:H4 str. 2011C-3493 peptidase T YP_006779664.1 3050794 R 1133852 CDS YP_006779665.1 407482516 13701040 3052273..3053409 1 NC_018658.1 COG3842 ABC-type spermidine/putrescine transport systems, ATPase components; putrescine/spermidine ABC transporter ATPase 3053409 potA 13701040 potA Escherichia coli O104:H4 str. 2011C-3493 putrescine/spermidine ABC transporter ATPase YP_006779665.1 3052273 D 1133852 CDS YP_006779666.1 407482517 13701041 3053393..3054250 1 NC_018658.1 COG1176 ABC-type spermidine/putrescine transport system, permease component I; spermidine/putrescine ABC transporter permease 3054250 potB 13701041 potB Escherichia coli O104:H4 str. 2011C-3493 spermidine/putrescine ABC transporter permease YP_006779666.1 3053393 D 1133852 CDS YP_006779667.1 407482518 13701042 3054247..3055041 1 NC_018658.1 COG1177 ABC-type spermidine/putrescine transport system, permease component II; spermidine/putrescine ABC transporter permease 3055041 potC 13701042 potC Escherichia coli O104:H4 str. 2011C-3493 spermidine/putrescine ABC transporter permease YP_006779667.1 3054247 D 1133852 CDS YP_006779668.1 407482519 13701043 3055038..3056084 1 NC_018658.1 COG0687 Spermidine/putrescine-binding periplasmic protein; spermidine/putrescine ABC transporter substrate-binding protein 3056084 potD 13701043 potD Escherichia coli O104:H4 str. 2011C-3493 spermidine/putrescine ABC transporter substrate-binding protein YP_006779668.1 3055038 D 1133852 CDS YP_006779669.1 407482520 13701044 3056142..3056603 1 NC_018658.1 inner membrane protein 3056603 13701044 O3K_14950 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006779669.1 3056142 D 1133852 CDS YP_006779670.1 407482521 13701045 3056678..3057388 1 NC_018658.1 inner membrane protein 3057388 13701045 O3K_14955 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006779670.1 3056678 D 1133852 CDS YP_006779671.1 407482522 13701046 complement(3057527..3058348) 1 NC_018658.1 COG0846 NAD-dependent protein deacetylases, SIR2 family; NAD-dependent deacetylase 3058348 13701046 O3K_14960 Escherichia coli O104:H4 str. 2011C-3493 NAD-dependent deacetylase YP_006779671.1 3057527 R 1133852 CDS YP_006779672.1 407482523 13701047 complement(3058364..3059275) 1 NC_018658.1 COG1940 Transcriptional regulator/sugar kinase; N-acetyl-D-glucosamine kinase 3059275 13701047 O3K_14965 Escherichia coli O104:H4 str. 2011C-3493 N-acetyl-D-glucosamine kinase YP_006779672.1 3058364 R 1133852 CDS YP_006779673.1 407482524 13701048 complement(3059304..3060548) 1 NC_018658.1 COG4591 ABC-type transport system, involved in lipoprotein release, permease component; outer membrane-specific lipoprotein transporter subunit LolE 3060548 13701048 O3K_14970 Escherichia coli O104:H4 str. 2011C-3493 outer membrane-specific lipoprotein transporter subunit LolE YP_006779673.1 3059304 R 1133852 CDS YP_006779674.1 407482525 13701049 complement(3060548..3061249) 1 NC_018658.1 COG1136 ABC-type antimicrobial peptide transport system, ATPase component; lipoprotein transporter ATP-binding subunit 3061249 lolD 13701049 lolD Escherichia coli O104:H4 str. 2011C-3493 lipoprotein transporter ATP-binding subunit YP_006779674.1 3060548 R 1133852 CDS YP_006779675.1 407482526 13701050 complement(3061242..3062441) 1 NC_018658.1 COG4591 ABC-type transport system, involved in lipoprotein release, permease component; outer membrane-specific lipoprotein transporter subunit LolC 3062441 13701050 O3K_14980 Escherichia coli O104:H4 str. 2011C-3493 outer membrane-specific lipoprotein transporter subunit LolC YP_006779675.1 3061242 R 1133852 CDS YP_006779676.1 407482527 13701051 3062703..3063776 1 NC_018658.1 COG4763 Predicted membrane protein; inner membrane protein 3063776 13701051 O3K_14985 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006779676.1 3062703 D 1133852 CDS YP_006779677.1 407482528 13701052 3063904..3067350 1 NC_018658.1 COG1197 Transcription-repair coupling factor (superfamily II helicase); transcription-repair coupling factor 3067350 13701052 O3K_14990 Escherichia coli O104:H4 str. 2011C-3493 transcription-repair coupling factor YP_006779677.1 3063904 D 1133852 CDS YP_006779678.1 407482529 13701053 3067494..3068456 1 NC_018658.1 COG1376 Uncharacterized protein conserved in bacteria; hypothetical protein 3068456 13701053 O3K_14995 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779678.1 3067494 D 1133852 CDS YP_006779679.1 407482530 13701054 complement(3068539..3068796) 1 NC_018658.1 hypothetical protein 3068796 13701054 O3K_15000 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779679.1 3068539 R 1133852 CDS YP_006779680.1 407482531 13701055 3069037..3069669 1 NC_018658.1 COG1309 Transcriptional regulator; hypothetical protein 3069669 13701055 O3K_15005 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779680.1 3069037 D 1133852 CDS YP_006779681.1 407482532 13701056 complement(3069731..3070270) 1 NC_018658.1 COG3134 Predicted outer membrane lipoprotein; hypothetical protein 3070270 13701056 O3K_15010 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779681.1 3069731 R 1133852 CDS YP_006779682.1 407482533 13701057 complement(3070480..3071784) 1 NC_018658.1 COG1252 NADH dehydrogenase, FAD-containing subunit; respiratory NADH dehydrogenase 2/cupric reductase 3071784 13701057 O3K_15015 Escherichia coli O104:H4 str. 2011C-3493 respiratory NADH dehydrogenase 2/cupric reductase YP_006779682.1 3070480 R 1133852 CDS YP_006779683.1 407482534 13701058 complement(3072192..3072734) 1 NC_018658.1 COG3150 Predicted esterase; hypothetical protein 3072734 13701058 O3K_15020 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779683.1 3072192 R 1133852 CDS YP_006779684.1 407482535 13701059 complement(3072757..3073782) 1 NC_018658.1 COG1472 Beta-glucosidase-related glycosidases; beta-hexosaminidase 3073782 13701059 O3K_15025 Escherichia coli O104:H4 str. 2011C-3493 beta-hexosaminidase YP_006779684.1 3072757 R 1133852 CDS YP_006779685.1 407482536 13701060 complement(3073793..3074617) 1 NC_018658.1 COG0510 Predicted choline kinase involved in LPS biosynthesis; thiamine kinase 3074617 thiK 13701060 thiK Escherichia coli O104:H4 str. 2011C-3493 thiamine kinase YP_006779685.1 3073793 R 1133852 CDS YP_006779686.1 407482537 13701061 complement(3074598..3075239) 1 NC_018658.1 COG3417 Collagen-binding surface adhesin SpaP (antigen I/II family); hypothetical protein 3075239 13701061 O3K_15035 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779686.1 3074598 R 1133852 CDS YP_006779687.1 407482538 13701062 complement(3075253..3075630) 1 NC_018658.1 COG5633 Predicted periplasmic lipoprotein; lipoprotein 3075630 13701062 O3K_15040 Escherichia coli O104:H4 str. 2011C-3493 lipoprotein YP_006779687.1 3075253 R 1133852 CDS YP_006779688.1 407482539 13701063 complement(3075633..3075992) 1 NC_018658.1 COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases; purine nucleoside phosphoramidase 3075992 13701063 O3K_15045 Escherichia coli O104:H4 str. 2011C-3493 purine nucleoside phosphoramidase YP_006779688.1 3075633 R 1133852 CDS YP_006779689.1 407482540 13701064 3076326..3078515 1 NC_018658.1 COG4773 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid; ferric-rhodotorulic acid outer membrane transporter 3078515 13701064 O3K_15050 Escherichia coli O104:H4 str. 2011C-3493 ferric-rhodotorulic acid outer membrane transporter YP_006779689.1 3076326 D 1133852 CDS YP_006779690.1 407482541 13701065 complement(3078575..3080008) 1 NC_018658.1 COG1263 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific; PTS system glucose-specific transporter subunit IIBC 3080008 13701065 O3K_15055 Escherichia coli O104:H4 str. 2011C-3493 PTS system glucose-specific transporter subunit IIBC YP_006779690.1 3078575 R 1133852 CDS YP_006779691.1 407482542 13701066 complement(3080303..3081100) 1 NC_018658.1 COG0084 Mg-dependent DNase; putative DNAse 3081100 13701066 O3K_15060 Escherichia coli O104:H4 str. 2011C-3493 putative DNAse YP_006779691.1 3080303 R 1133852 CDS YP_006779692.1 407482543 13701067 complement(3081111..3082115) 1 NC_018658.1 COG0470 ATPase involved in DNA replication; DNA polymerase III subunit delta' 3082115 13701067 O3K_15065 Escherichia coli O104:H4 str. 2011C-3493 DNA polymerase III subunit delta' YP_006779692.1 3081111 R 1133852 CDS YP_006779693.1 407482544 13701068 complement(3082112..3082753) 1 NC_018658.1 COG0125 Thymidylate kinase; thymidylate kinase 3082753 tmk 13701068 tmk Escherichia coli O104:H4 str. 2011C-3493 thymidylate kinase YP_006779693.1 3082112 R 1133852 CDS YP_006779694.1 407482545 13701069 complement(3082743..3083765) 1 NC_018658.1 COG1559 Predicted periplasmic solute-binding protein; putative aminodeoxychorismate lyase 3083765 13701069 O3K_15075 Escherichia coli O104:H4 str. 2011C-3493 putative aminodeoxychorismate lyase YP_006779694.1 3082743 R 1133852 CDS YP_006779695.1 407482546 13701070 complement(3083768..3084577) 1 NC_018658.1 COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; 4-amino-4-deoxychorismate lyase 3084577 13701070 O3K_15080 Escherichia coli O104:H4 str. 2011C-3493 4-amino-4-deoxychorismate lyase YP_006779695.1 3083768 R 1133852 CDS YP_006779696.1 407482547 13701071 complement(3084697..3085938) 1 NC_018658.1 COG0304 3-oxoacyl-(acyl-carrier-protein) synthase; 3-oxoacyl-(acyl carrier protein) synthase II 3085938 13701071 O3K_15085 Escherichia coli O104:H4 str. 2011C-3493 3-oxoacyl-(acyl carrier protein) synthase II YP_006779696.1 3084697 R 1133852 CDS YP_006779697.1 407482548 13701072 complement(3086026..3086262) 1 NC_018658.1 COG0236 Acyl carrier protein; hypothetical protein 3086262 13701072 O3K_15090 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779697.1 3086026 R 1133852 CDS YP_006779698.1 407482549 13701073 complement(3086473..3087207) 1 NC_018658.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); 3-ketoacyl-ACP reductase 3087207 fabG 13701073 fabG Escherichia coli O104:H4 str. 2011C-3493 3-ketoacyl-ACP reductase YP_006779698.1 3086473 R 1133852 CDS YP_006779699.1 407482550 13701074 complement(3087220..3088149) 1 NC_018658.1 COG0331 (acyl-carrier-protein) S-malonyltransferase; malonyl-CoA-[acyl-carrier-protein] transacylase 3088149 13701074 O3K_15100 Escherichia coli O104:H4 str. 2011C-3493 malonyl-CoA-[acyl-carrier-protein] transacylase YP_006779699.1 3087220 R 1133852 CDS YP_006779700.1 407482551 13701075 complement(3088165..3089118) 1 NC_018658.1 COG0332 3-oxoacyl-[acyl-carrier-protein] synthase III; 3-oxoacyl-ACP synthase 3089118 13701075 O3K_15105 Escherichia coli O104:H4 str. 2011C-3493 3-oxoacyl-ACP synthase YP_006779700.1 3088165 R 1133852 CDS YP_006779701.1 407482552 13701076 complement(3089186..3090256) 1 NC_018658.1 COG0416 Fatty acid/phospholipid biosynthesis enzyme; putative phosphate acyltransferase 3090256 13701076 O3K_15110 Escherichia coli O104:H4 str. 2011C-3493 putative phosphate acyltransferase YP_006779701.1 3089186 R 1133852 CDS YP_006779702.1 407482553 13701077 complement(3090337..3090510) 1 NC_018658.1 COG0333 Ribosomal protein L32; 50S ribosomal protein L32 3090510 rpmF 13701077 rpmF Escherichia coli O104:H4 str. 2011C-3493 50S ribosomal protein L32 YP_006779702.1 3090337 R 1133852 CDS YP_006779703.1 407482554 13701078 complement(3090562..3091083) 1 NC_018658.1 COG1399 Predicted metal-binding, possibly nucleic acid-binding protein; hypothetical protein 3091083 13701078 O3K_15120 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779703.1 3090562 R 1133852 CDS YP_006779704.1 407482555 13701079 3091282..3091866 1 NC_018658.1 COG0424 Nucleotide-binding protein implicated in inhibition of septum formation; Maf-like protein 3091866 13701079 O3K_15125 Escherichia coli O104:H4 str. 2011C-3493 Maf-like protein YP_006779704.1 3091282 D 1133852 CDS YP_006779705.1 407482556 13701080 complement(3091978..3092937) 1 NC_018658.1 COG0564 Pseudouridylate synthases, 23S RNA-specific; 23S rRNA pseudouridylate synthase C 3092937 13701080 O3K_15130 Escherichia coli O104:H4 str. 2011C-3493 23S rRNA pseudouridylate synthase C YP_006779705.1 3091978 R 1133852 CDS YP_006779706.1 407482557 13701081 complement(3093055..3093375) 1 NC_018658.1 hypothetical protein 3093375 13701081 O3K_15135 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779706.1 3093055 R 1133852 CDS YP_006779707.1 407482558 13701082 3093510..3096695 1 NC_018658.1 COG1530 Ribonucleases G and E; ribonuclease E 3096695 rne 13701082 rne Escherichia coli O104:H4 str. 2011C-3493 ribonuclease E YP_006779707.1 3093510 D 1133852 CDS YP_006779708.1 407482559 13701083 complement(3096892..3097845) 1 NC_018658.1 COG1344 Flagellin and related hook-associated proteins; flagellar hook-associated protein FlgL 3097845 flgL 13701083 flgL Escherichia coli O104:H4 str. 2011C-3493 flagellar hook-associated protein FlgL YP_006779708.1 3096892 R 1133852 CDS YP_006779709.1 407482560 13701084 complement(3097857..3099500) 1 NC_018658.1 COG1256 Flagellar hook-associated protein; flagellar hook-associated protein FlgK 3099500 flgK 13701084 flgK Escherichia coli O104:H4 str. 2011C-3493 flagellar hook-associated protein FlgK YP_006779709.1 3097857 R 1133852 CDS YP_006779710.1 407482561 13701085 complement(3099566..3100507) 1 NC_018658.1 COG3951 Rod binding protein; flagellar rod assembly protein/muramidase FlgJ 3100507 flgJ 13701085 flgJ Escherichia coli O104:H4 str. 2011C-3493 flagellar rod assembly protein/muramidase FlgJ YP_006779710.1 3099566 R 1133852 CDS YP_006779711.1 407482562 13701086 complement(3100507..3101604) 1 NC_018658.1 COG1706 Flagellar basal-body P-ring protein; flagellar basal body P-ring protein 3101604 flgI 13701086 flgI Escherichia coli O104:H4 str. 2011C-3493 flagellar basal body P-ring protein YP_006779711.1 3100507 R 1133852 CDS YP_006779712.1 407482563 13701087 complement(3101616..3102314) 1 NC_018658.1 COG2063 Flagellar basal body L-ring protein; flagellar basal body L-ring protein 3102314 flgH 13701087 flgH Escherichia coli O104:H4 str. 2011C-3493 flagellar basal body L-ring protein YP_006779712.1 3101616 R 1133852 CDS YP_006779713.1 407482564 13701088 complement(3102367..3103149) 1 NC_018658.1 COG4786 Flagellar basal body rod protein; flagellar basal body rod protein FlgG 3103149 flgG 13701088 flgG Escherichia coli O104:H4 str. 2011C-3493 flagellar basal body rod protein FlgG YP_006779713.1 3102367 R 1133852 CDS YP_006779714.1 407482565 13701089 complement(3103321..3104076) 1 NC_018658.1 COG4787 Flagellar basal body rod protein; flagellar basal body rod protein FlgF 3104076 flgF 13701089 flgF Escherichia coli O104:H4 str. 2011C-3493 flagellar basal body rod protein FlgF YP_006779714.1 3103321 R 1133852 CDS YP_006779715.1 407482566 13701090 complement(3104096..3105301) 1 NC_018658.1 COG1749 Flagellar hook protein FlgE; flagellar hook protein FlgE 3105301 flgE 13701090 flgE Escherichia coli O104:H4 str. 2011C-3493 flagellar hook protein FlgE YP_006779715.1 3104096 R 1133852 CDS YP_006779716.1 407482567 13701091 complement(3105326..3106021) 1 NC_018658.1 COG1843 Flagellar hook capping protein; flagellar basal body rod modification protein 3106021 flgD 13701091 flgD Escherichia coli O104:H4 str. 2011C-3493 flagellar basal body rod modification protein YP_006779716.1 3105326 R 1133852 CDS YP_006779717.1 407482568 13701092 complement(3106033..3106437) 1 NC_018658.1 COG1558 Flagellar basal body rod protein; flagellar basal body rod protein FlgC 3106437 flgC 13701092 flgC Escherichia coli O104:H4 str. 2011C-3493 flagellar basal body rod protein FlgC YP_006779717.1 3106033 R 1133852 CDS YP_006779718.1 407482569 13701093 complement(3106441..3106857) 1 NC_018658.1 COG1815 Flagellar basal body protein; flagellar basal body rod protein FlgB 3106857 flgB 13701093 flgB Escherichia coli O104:H4 str. 2011C-3493 flagellar basal body rod protein FlgB YP_006779718.1 3106441 R 1133852 CDS YP_006779719.1 407482570 13701094 3107012..3107671 1 NC_018658.1 COG1261 Flagellar basal body P-ring biosynthesis protein; flagellar basal body P-ring biosynthesis protein FlgA 3107671 flgA 13701094 flgA Escherichia coli O104:H4 str. 2011C-3493 flagellar basal body P-ring biosynthesis protein FlgA YP_006779719.1 3107012 D 1133852 CDS YP_006779720.1 407482571 13701095 3107747..3108040 1 NC_018658.1 COG2747 Negative regulator of flagellin synthesis (anti-sigma28 factor); anti-sigma-28 factor FlgM 3108040 13701095 O3K_15205 Escherichia coli O104:H4 str. 2011C-3493 anti-sigma-28 factor FlgM YP_006779720.1 3107747 D 1133852 CDS YP_006779721.1 407482572 13701096 3108045..3108461 1 NC_018658.1 COG3418 Flagellar biosynthesis/type III secretory pathway chaperone; flagella synthesis chaperone protein FlgN 3108461 13701096 O3K_15210 Escherichia coli O104:H4 str. 2011C-3493 flagella synthesis chaperone protein FlgN YP_006779721.1 3108045 D 1133852 CDS YP_006779722.1 407482573 13701097 complement(3108501..3110036) 1 NC_018658.1 COG0728 Uncharacterized membrane protein, putative virulence factor; putative inner membrane protein MviN 3110036 13701097 O3K_15215 Escherichia coli O104:H4 str. 2011C-3493 putative inner membrane protein MviN YP_006779722.1 3108501 R 1133852 CDS YP_006779723.1 407482574 13701098 complement(3110146..3111069) 1 NC_018658.1 COG0673 Predicted dehydrogenases and related proteins; oxidoreductase 3111069 13701098 O3K_15220 Escherichia coli O104:H4 str. 2011C-3493 oxidoreductase YP_006779723.1 3110146 R 1133852 CDS YP_006779724.1 407482575 13701099 complement(3111071..3111718) 1 NC_018658.1 COG3132 Uncharacterized protein conserved in bacteria; hypothetical protein 3111718 13701099 O3K_15225 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779724.1 3111071 R 1133852 CDS YP_006779725.1 407482576 13701100 complement(3111729..3112313) 1 NC_018658.1 COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins; ribosomal-protein-S5-alanine N-acetyltransferase 3112313 13701100 O3K_15230 Escherichia coli O104:H4 str. 2011C-3493 ribosomal-protein-S5-alanine N-acetyltransferase YP_006779725.1 3111729 R 1133852 CDS YP_006779726.1 407482577 13701101 3112549..3113757 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; multidrug resistance protein MdtH 3113757 13701101 O3K_15235 Escherichia coli O104:H4 str. 2011C-3493 multidrug resistance protein MdtH YP_006779726.1 3112549 D 1133852 CDS YP_006779727.1 407482578 13701102 3113821..3114468 1 NC_018658.1 COG2999 Glutaredoxin 2; glutaredoxin 3114468 13701102 O3K_15240 Escherichia coli O104:H4 str. 2011C-3493 glutaredoxin YP_006779727.1 3113821 D 1133852 CDS YP_006779728.1 407482579 13701103 3114602..3115162 1 NC_018658.1 lipoprotein 3115162 13701103 O3K_15245 Escherichia coli O104:H4 str. 2011C-3493 lipoprotein YP_006779728.1 3114602 D 1133852 CDS YP_006779729.1 407482580 13701104 3115268..3116314 1 NC_018658.1 COG0418 Dihydroorotase; dihydroorotase 3116314 13701104 O3K_15250 Escherichia coli O104:H4 str. 2011C-3493 dihydroorotase YP_006779729.1 3115268 D 1133852 CDS YP_006779730.1 407482581 13701105 3116388..3116633 1 NC_018658.1 DNA damage-inducible protein I 3116633 13701105 O3K_15255 Escherichia coli O104:H4 str. 2011C-3493 DNA damage-inducible protein I YP_006779730.1 3116388 D 1133852 CDS YP_006779731.1 407482582 13701106 3116923..3117177 1 NC_018658.1 biofilm formation regulatory protein BssS 3117177 bssS 13701106 bssS Escherichia coli O104:H4 str. 2011C-3493 biofilm formation regulatory protein BssS YP_006779731.1 3116923 D 1133852 CDS YP_006779732.1 407482583 13701107 3117292..3118410 1 NC_018658.1 COG0665 Glycine/D-amino acid oxidases (deaminating); N-methyltryptophan oxidase 3118410 solA 13701107 solA Escherichia coli O104:H4 str. 2011C-3493 N-methyltryptophan oxidase YP_006779732.1 3117292 D 1133852 CDS YP_006779733.1 407482584 13701108 3118458..3118571 1 NC_018658.1 hypothetical protein 3118571 13701108 O3K_15270 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779733.1 3118458 D 1133852 CDS YP_006779734.1 407482585 13701109 3118832..3119398 1 NC_018658.1 COG3038 Cytochrome B561; cytochrome 3119398 13701109 O3K_15275 Escherichia coli O104:H4 str. 2011C-3493 cytochrome YP_006779734.1 3118832 D 1133852 CDS YP_006779735.1 407482586 13701110 3119402..3119977 1 NC_018658.1 COG2353 Uncharacterized conserved protein; hypothetical protein 3119977 13701110 O3K_15280 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779735.1 3119402 D 1133852 CDS YP_006779736.1 407482587 13701111 complement(3120019..3121071) 1 NC_018658.1 COG1054 Predicted sulfurtransferase; putative rhodanese-related sulfurtransferase 3121071 13701111 O3K_15285 Escherichia coli O104:H4 str. 2011C-3493 putative rhodanese-related sulfurtransferase YP_006779736.1 3120019 R 1133852 CDS YP_006779737.1 407482588 13701112 3121296..3122216 1 NC_018658.1 COG1560 Lauroyl/myristoyl acyltransferase; lipid A biosynthesis lauroyl acyltransferase 3122216 13701112 O3K_15290 Escherichia coli O104:H4 str. 2011C-3493 lipid A biosynthesis lauroyl acyltransferase YP_006779737.1 3121296 D 1133852 CDS YP_006779738.1 407482589 13701113 3122388..3123614 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; drug efflux system protein MdtG 3123614 13701113 O3K_15295 Escherichia coli O104:H4 str. 2011C-3493 drug efflux system protein MdtG YP_006779738.1 3122388 D 1133852 CDS YP_006779739.1 407482590 13701114 3123697..3124071 1 NC_018658.1 secY/secA suppressor protein 3124071 13701114 O3K_15300 Escherichia coli O104:H4 str. 2011C-3493 secY/secA suppressor protein YP_006779739.1 3123697 D 1133852 CDS YP_006779740.1 407482591 13701115 complement(3124072..3124299) 1 NC_018658.1 COG5645 Predicted periplasmic lipoprotein; lipoprotein 3124299 13701115 O3K_15305 Escherichia coli O104:H4 str. 2011C-3493 lipoprotein YP_006779740.1 3124072 R 1133852 CDS YP_006779741.1 407482592 13701116 complement(3124472..3127015) 1 NC_018658.1 COG2943 Membrane glycosyltransferase; glucosyltransferase MdoH 3127015 13701116 O3K_15310 Escherichia coli O104:H4 str. 2011C-3493 glucosyltransferase MdoH YP_006779741.1 3124472 R 1133852 CDS YP_006779742.1 407482593 13701117 complement(3127008..3128543) 1 NC_018658.1 COG3131 Periplasmic glucans biosynthesis protein; glucan biosynthesis protein G 3128543 mdoG 13701117 mdoG Escherichia coli O104:H4 str. 2011C-3493 glucan biosynthesis protein G YP_006779742.1 3127008 R 1133852 CDS YP_006779743.1 407482594 13701118 3128937..3130094 1 NC_018658.1 glucans biosynthesis protein 3130094 opgC 13701118 opgC Escherichia coli O104:H4 str. 2011C-3493 glucans biosynthesis protein YP_006779743.1 3128937 D 1133852 CDS YP_006779744.1 407482595 13701119 complement(3130102..3131523) 1 NC_018658.1 COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipi n synthases and related enzymes; phospholipase D/transphosphatidylase 3131523 13701119 O3K_15325 Escherichia coli O104:H4 str. 2011C-3493 phospholipase D/transphosphatidylase YP_006779744.1 3130102 R 1133852 CDS YP_006779745.1 407482596 13701120 complement(3131525..3132058) 1 NC_018658.1 COG2110 Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1; RNase III inhibitor 3132058 13701120 O3K_15330 Escherichia coli O104:H4 str. 2011C-3493 RNase III inhibitor YP_006779745.1 3131525 R 1133852 CDS YP_006779746.1 407482597 13701121 complement(3132153..3132353) 1 NC_018658.1 hypothetical protein 3132353 13701121 O3K_15335 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779746.1 3132153 R 1133852 CDS YP_006779747.1 407482598 13701122 complement(3132584..3132916) 1 NC_018658.1 curli assembly protein CsgC 3132916 csgC 13701122 csgC Escherichia coli O104:H4 str. 2011C-3493 curli assembly protein CsgC YP_006779747.1 3132584 R 1133852 CDS YP_006779748.1 407482599 13701123 complement(3132975..3133430) 1 NC_018658.1 major curlin subunit 3133430 csgA 13701123 csgA Escherichia coli O104:H4 str. 2011C-3493 major curlin subunit YP_006779748.1 3132975 R 1133852 CDS YP_006779749.1 407482600 13701124 complement(3133471..3133926) 1 NC_018658.1 curlin minor subunit CsgB 3133926 csgB 13701124 csgB Escherichia coli O104:H4 str. 2011C-3493 curlin minor subunit CsgB YP_006779749.1 3133471 R 1133852 CDS YP_006779750.1 407482601 13701125 3134680..3135330 1 NC_018658.1 COG2771 DNA-binding HTH domain-containing proteins; DNA-binding transcriptional regulator CsgD 3135330 13701125 O3K_15355 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator CsgD YP_006779750.1 3134680 D 1133852 CDS YP_006779751.1 407482602 13701126 3135335..3135724 1 NC_018658.1 COG4670 Acyl CoA:acetate/3-ketoacid CoA transferase; curli assembly protein CsgE 3135724 13701126 O3K_15360 Escherichia coli O104:H4 str. 2011C-3493 curli assembly protein CsgE YP_006779751.1 3135335 D 1133852 CDS YP_006779752.1 407482603 13701127 3135749..3136165 1 NC_018658.1 curli assembly protein CsgF 3136165 13701127 O3K_15365 Escherichia coli O104:H4 str. 2011C-3493 curli assembly protein CsgF YP_006779752.1 3135749 D 1133852 CDS YP_006779753.1 407482604 13701128 3136192..3137025 1 NC_018658.1 COG1462 Uncharacterized protein involved in formation of curli polymers; curli production assembly/transport protein CsgG 3137025 13701128 O3K_15370 Escherichia coli O104:H4 str. 2011C-3493 curli production assembly/transport protein CsgG YP_006779753.1 3136192 D 1133852 CDS YP_006779754.1 407482605 13701129 complement(3137089..3137580) 1 NC_018658.1 inner membrane protein 3137580 13701129 O3K_15375 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006779754.1 3137089 R 1133852 CDS YP_006779755.1 407482606 13701130 complement(3137682..3138236) 1 NC_018658.1 COG3381 Uncharacterized component of anaerobic dehydrogenases; hypothetical protein 3138236 13701130 O3K_15380 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779755.1 3137682 R 1133852 CDS YP_006779756.1 407482607 13701131 complement(3138260..3138997) 1 NC_018658.1 COG1387 Histidinol phosphatase and related hydrolases of the PHP family; hydrolase 3138997 13701131 O3K_15385 Escherichia coli O104:H4 str. 2011C-3493 hydrolase YP_006779756.1 3138260 R 1133852 CDS YP_006779757.1 407482608 13701132 complement(3139052..3139990) 1 NC_018658.1 COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; bifunctional glyoxylate/hydroxypyruvate reductase A 3139990 ghrA 13701132 ghrA Escherichia coli O104:H4 str. 2011C-3493 bifunctional glyoxylate/hydroxypyruvate reductase A YP_006779757.1 3139052 R 1133852 CDS YP_006779758.1 407482609 13701134 complement(3140461..3141303) 1 NC_018658.1 hypothetical protein 3141303 13701134 O3K_15395 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779758.1 3140461 R 1133852 CDS YP_006779759.1 407482610 13701135 complement(3141388..3141585) 1 NC_018658.1 hypothetical protein 3141585 13701135 O3K_15400 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779759.1 3141388 R 1133852 CDS YP_006779760.1 407482611 13701136 complement(3141597..3142085) 1 NC_018658.1 hypothetical protein 3142085 13701136 O3K_15405 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779760.1 3141597 R 1133852 CDS YP_006779761.1 407482612 13701137 complement(3142085..3142459) 1 NC_018658.1 hypothetical protein 3142459 13701137 O3K_15410 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779761.1 3142085 R 1133852 CDS YP_006779762.1 407482613 13701138 complement(3142550..3142903) 1 NC_018658.1 CP4-44 prophage YeeV-YeeU toxin-antitoxin system toxin 3142903 13701138 O3K_15415 Escherichia coli O104:H4 str. 2011C-3493 CP4-44 prophage YeeV-YeeU toxin-antitoxin system toxin YP_006779762.1 3142550 R 1133852 CDS YP_006779763.1 407482614 13701139 complement(3142979..3143200) 1 NC_018658.1 hypothetical protein 3143200 13701139 O3K_15420 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779763.1 3142979 R 1133852 CDS YP_006779764.1 407482615 13701140 complement(3143263..3143739) 1 NC_018658.1 COG2003 DNA repair proteins; radC-like protein YeeS 3143739 13701140 O3K_15425 Escherichia coli O104:H4 str. 2011C-3493 radC-like protein YeeS YP_006779764.1 3143263 R 1133852 CDS YP_006779765.1 407482616 13701141 complement(3143755..3144228) 1 NC_018658.1 hypothetical protein 3144228 13701141 O3K_15430 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779765.1 3143755 R 1133852 CDS YP_006779766.1 407482617 13701142 complement(3144322..3144567) 1 NC_018658.1 hypothetical protein 3144567 13701142 O3K_15435 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779766.1 3144322 R 1133852 CDS YP_006779767.1 407482618 13701143 complement(3144567..3145388) 1 NC_018658.1 hypothetical protein 3145388 13701143 O3K_15440 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779767.1 3144567 R 1133852 CDS YP_006779768.1 407482619 13701144 complement(3145609..3146019) 1 NC_018658.1 hypothetical protein 3146019 13701144 O3K_15445 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779768.1 3145609 R 1133852 CDS YP_006779769.1 407482620 13701145 complement(3146035..3146718) 1 NC_018658.1 hypothetical protein 3146718 13701145 O3K_15450 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779769.1 3146035 R 1133852 CDS YP_006779770.1 407482621 13701146 complement(3146852..3147922) 1 NC_018658.1 COG1752 Predicted esterase of the alpha-beta hydrolase superfamily; hypothetical protein 3147922 13701146 O3K_15455 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779770.1 3146852 R 1133852 CDS YP_006779771.1 407482622 13701147 complement(3147919..3148824) 1 NC_018658.1 hypothetical protein 3148824 13701147 O3K_15460 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779771.1 3147919 R 1133852 CDS YP_006779772.1 407482623 13701148 complement(3148821..3151217) 1 NC_018658.1 COG0699 Predicted GTPases (dynamin-related); hypothetical protein 3151217 13701148 O3K_15465 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779772.1 3148821 R 1133852 CDS YP_006779773.1 407482624 13701149 complement(3153689..3154561) 1 NC_018658.1 COG3596 Predicted GTPase; GTP-binding protein 3154561 13701149 O3K_15485 Escherichia coli O104:H4 str. 2011C-3493 GTP-binding protein YP_006779773.1 3153689 R 1133852 CDS YP_006779774.1 407482625 13701150 complement(3155373..3155798) 1 NC_018658.1 COG2963 Transposase and inactivated derivatives; IS66 transposase 3155798 13701150 O3K_15490 Escherichia coli O104:H4 str. 2011C-3493 IS66 transposase YP_006779774.1 3155373 R 1133852 CDS YP_006779775.1 407482626 13701151 complement(3155956..3157197) 1 NC_018658.1 COG2310 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1; tellurium resistance protein TerF 3157197 13701151 O3K_15495 Escherichia coli O104:H4 str. 2011C-3493 tellurium resistance protein TerF YP_006779775.1 3155956 R 1133852 CDS YP_006779776.1 407482627 13701152 complement(3157629..3158204) 1 NC_018658.1 COG2310 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1; putative tellurium resistance protein TerE 3158204 13701152 O3K_15500 Escherichia coli O104:H4 str. 2011C-3493 putative tellurium resistance protein TerE YP_006779776.1 3157629 R 1133852 CDS YP_006779777.1 407482628 13701153 complement(3158273..3158851) 1 NC_018658.1 COG2310 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1; tellurium resistance protein 3158851 13701153 O3K_15505 Escherichia coli O104:H4 str. 2011C-3493 tellurium resistance protein YP_006779777.1 3158273 R 1133852 CDS YP_006779778.1 407482629 13701154 complement(3158900..3159940) 1 NC_018658.1 COG0861 Membrane protein TerC, possibly involved in tellurium resistance; Tellurium resistance protein TerC 3159940 13701154 O3K_15510 Escherichia coli O104:H4 str. 2011C-3493 Tellurium resistance protein TerC YP_006779778.1 3158900 R 1133852 CDS YP_006779779.1 407482630 13701155 complement(3159963..3160418) 1 NC_018658.1 COG3793 Tellurite resistance protein; putative tellurium resistance protein TerB 3160418 13701155 O3K_15515 Escherichia coli O104:H4 str. 2011C-3493 putative tellurium resistance protein TerB YP_006779779.1 3159963 R 1133852 CDS YP_006779780.1 407482631 13701156 complement(3160441..3161598) 1 NC_018658.1 COG2310 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1; putative tellurium resistance protein TerA 3161598 13701156 O3K_15520 Escherichia coli O104:H4 str. 2011C-3493 putative tellurium resistance protein TerA YP_006779780.1 3160441 R 1133852 CDS YP_006779781.1 407482632 13701157 complement(3161598..3162179) 1 NC_018658.1 COG2310 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1; tellurium resistance protein 3162179 13701157 O3K_15525 Escherichia coli O104:H4 str. 2011C-3493 tellurium resistance protein YP_006779781.1 3161598 R 1133852 CDS YP_006779782.1 407482633 13701158 3162502..3163560 1 NC_018658.1 COG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit; hypothetical protein 3163560 13701158 O3K_15530 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779782.1 3162502 D 1133852 CDS YP_006779783.1 407482634 13701159 3163570..3164712 1 NC_018658.1 hypothetical protein 3164712 13701159 O3K_15535 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779783.1 3163570 D 1133852 CDS YP_006779784.1 407482635 13701160 3164705..3165478 1 NC_018658.1 COG0561 Predicted hydrolases of the HAD superfamily; hypothetical protein 3165478 13701160 O3K_15540 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779784.1 3164705 D 1133852 CDS YP_006779785.1 407482636 13701161 3165480..3166559 1 NC_018658.1 putative ATP-binding protein 3166559 13701161 O3K_15545 Escherichia coli O104:H4 str. 2011C-3493 putative ATP-binding protein YP_006779785.1 3165480 D 1133852 CDS YP_006779786.1 407482637 13701162 3166559..3167515 1 NC_018658.1 COG2301 Citrate lyase beta subunit; hypothetical protein 3167515 13701162 O3K_15550 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779786.1 3166559 D 1133852 CDS YP_006779787.1 407482638 13701163 3167526..3168734 1 NC_018658.1 hypothetical protein 3168734 13701163 O3K_15555 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779787.1 3167526 D 1133852 CDS YP_006779788.1 407482639 13701164 3168752..3169219 1 NC_018658.1 putative tellurium resistance protein TerW 3169219 13701164 O3K_15560 Escherichia coli O104:H4 str. 2011C-3493 putative tellurium resistance protein TerW YP_006779788.1 3168752 D 1133852 CDS YP_006779789.1 407482640 13701165 complement(3169389..3169520) 1 NC_018658.1 hypothetical protein 3169520 13701165 O3K_15565 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779789.1 3169389 R 1133852 CDS YP_006779790.1 407482641 13701166 3169683..3170321 1 NC_018658.1 COG4245 Uncharacterized protein encoded in toxicity protection region of plasmid R478, contains von Willebrand factor (vWF) domain; TerY1 3170321 13701166 O3K_15570 Escherichia coli O104:H4 str. 2011C-3493 TerY1 YP_006779790.1 3169683 D 1133852 CDS YP_006779791.1 407482642 13701167 3170344..3170982 1 NC_018658.1 COG2310 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1; tellurium resistance protein terX 3170982 13701167 O3K_15575 Escherichia coli O104:H4 str. 2011C-3493 tellurium resistance protein terX YP_006779791.1 3170344 D 1133852 CDS YP_006779792.1 407482643 13701168 3170982..3171620 1 NC_018658.1 COG4245 Uncharacterized protein encoded in toxicity protection region of plasmid R478, contains von Willebrand factor (vWF) domain; TerY2 3171620 13701168 O3K_15580 Escherichia coli O104:H4 str. 2011C-3493 TerY2 YP_006779792.1 3170982 D 1133852 CDS YP_006779793.1 407482644 13701169 3171705..3172745 1 NC_018658.1 COG4245 Uncharacterized protein encoded in toxicity protection region of plasmid R478, contains von Willebrand factor (vWF) domain; TerY3 3172745 13701169 O3K_15585 Escherichia coli O104:H4 str. 2011C-3493 TerY3 YP_006779793.1 3171705 D 1133852 CDS YP_006779794.1 407482645 13701170 3172745..3174382 1 NC_018658.1 hypothetical protein 3174382 13701170 O3K_15590 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779794.1 3172745 D 1133852 CDS YP_006779795.1 407482646 13701171 3174408..3175907 1 NC_018658.1 COG0515 Serine/threonine protein kinase; protein kinase 3175907 13701171 O3K_15595 Escherichia coli O104:H4 str. 2011C-3493 protein kinase YP_006779795.1 3174408 D 1133852 CDS YP_006779796.1 407482647 13701172 3175995..3176663 1 NC_018658.1 COG4584 Transposase and inactivated derivatives; transposase 3176663 13701172 O3K_15600 Escherichia coli O104:H4 str. 2011C-3493 transposase YP_006779796.1 3175995 D 1133852 CDS YP_006779797.1 407482648 13701173 3176738..3176923 1 NC_018658.1 COG1484 DNA replication protein; IS100 transposase 3176923 13701173 O3K_15605 Escherichia coli O104:H4 str. 2011C-3493 IS100 transposase YP_006779797.1 3176738 D 1133852 CDS YP_006779798.1 407482649 13701175 3177492..3177668 1 NC_018658.1 hypothetical protein 3177668 13701175 O3K_15610 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779798.1 3177492 D 1133852 CDS YP_006779799.1 407482650 13701176 3178288..3178533 1 NC_018658.1 COG1943 Transposase and inactivated derivatives; transposase IS605 family, IS200 group 3178533 13701176 O3K_15615 Escherichia coli O104:H4 str. 2011C-3493 transposase IS605 family, IS200 group YP_006779799.1 3178288 D 1133852 CDS YP_006779800.1 407482651 13701177 complement(3178651..3179589) 1 NC_018658.1 COG0583 Transcriptional regulator; cell density-dependent motility repressor 3179589 13701177 O3K_15620 Escherichia coli O104:H4 str. 2011C-3493 cell density-dependent motility repressor YP_006779800.1 3178651 R 1133852 CDS YP_006779801.1 407482652 13701178 3179940..3180659 1 NC_018658.1 COG1794 Aspartate racemase; aspartate racemase 3180659 13701178 O3K_15625 Escherichia coli O104:H4 str. 2011C-3493 aspartate racemase YP_006779801.1 3179940 D 1133852 CDS YP_006779802.1 407482653 13701179 3180725..3182023 1 NC_018658.1 COG2704 Anaerobic C4-dicarboxylate transporter; anaerobic C4-dicarboxylate transporter 3182023 13701179 O3K_15630 Escherichia coli O104:H4 str. 2011C-3493 anaerobic C4-dicarboxylate transporter YP_006779802.1 3180725 D 1133852 CDS YP_006779803.1 407482654 13701180 complement(3182267..3182980) 1 NC_018658.1 COG2801 Transposase and inactivated derivatives; hypothetical protein 3182980 13701180 O3K_15635 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779803.1 3182267 R 1133852 CDS YP_006779804.1 407482655 13701181 complement(3183065..3183274) 1 NC_018658.1 COG1662 Transposase and inactivated derivatives, IS1 family; insertion element protein 3183274 13701181 O3K_15640 Escherichia coli O104:H4 str. 2011C-3493 insertion element protein YP_006779804.1 3183065 R 1133852 CDS YP_006779805.1 407482656 13701182 complement(3183275..3183568) 1 NC_018658.1 IS1; transposase ORF B, IS1 3183568 13701182 O3K_15645 Escherichia coli O104:H4 str. 2011C-3493 transposase ORF B, IS1 YP_006779805.1 3183275 R 1133852 CDS YP_006779806.1 407482657 13701183 complement(3183487..3183762) 1 NC_018658.1 COG3677 Transposase and inactivated derivatives; IS1 repressor protein InsA 3183762 13701183 O3K_15650 Escherichia coli O104:H4 str. 2011C-3493 IS1 repressor protein InsA YP_006779806.1 3183487 R 1133852 CDS YP_006779807.1 407482658 13701184 complement(3183791..3183910) 1 NC_018658.1 hypothetical protein 3183910 13701184 O3K_15655 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779807.1 3183791 R 1133852 CDS YP_006779808.1 407482659 13701185 complement(3184030..3185127) 1 NC_018658.1 COG3969 Predicted phosphoadenosine phosphosulfate sulfotransferase; hypothetical protein 3185127 13701185 O3K_15660 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779808.1 3184030 R 1133852 CDS YP_006779809.1 407482660 13701186 complement(3185636..3187855) 1 NC_018658.1 COG1112 Superfamily I DNA and RNA helicases and helicase subunits; putative UvrD/REP helicase-like protein 3187855 13701186 O3K_15665 Escherichia coli O104:H4 str. 2011C-3493 putative UvrD/REP helicase-like protein YP_006779809.1 3185636 R 1133852 CDS YP_006779810.1 407482661 13701187 complement(3188559..3189134) 1 NC_018658.1 hypothetical protein 3189134 13701187 O3K_15670 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779810.1 3188559 R 1133852 CDS YP_006779811.1 407482662 13701188 complement(3190109..3190342) 1 NC_018658.1 hypothetical protein 3190342 13701188 O3K_15675 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779811.1 3190109 R 1133852 CDS YP_006779812.1 407482663 13701189 complement(3190438..3191061) 1 NC_018658.1 hypothetical protein 3191061 13701189 O3K_15680 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779812.1 3190438 R 1133852 CDS YP_006779813.1 407482664 13701190 3193004..3193360 1 NC_018658.1 COG1266 Predicted metal-dependent membrane protease; hypothetical protein 3193360 13701190 O3K_15685 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779813.1 3193004 D 1133852 CDS YP_006779814.1 407482665 13701191 complement(3194356..3196458) 1 NC_018658.1 COG2274 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain; colicin V secretion/processing ATP binding protein 3196458 13701191 O3K_15690 Escherichia coli O104:H4 str. 2011C-3493 colicin V secretion/processing ATP binding protein YP_006779814.1 3194356 R 1133852 CDS YP_006779815.1 407482666 13701192 complement(3196451..3197638) 1 NC_018658.1 COG0845 Membrane-fusion protein; Colicin V secretion protein CvaA 3197638 13701192 O3K_15695 Escherichia coli O104:H4 str. 2011C-3493 Colicin V secretion protein CvaA YP_006779815.1 3196451 R 1133852 CDS YP_006779816.1 407482667 13701193 complement(3197878..3198330) 1 NC_018658.1 COG2994 ACP:hemolysin acyltransferase (hemolysin-activating protein); hypothetical protein 3198330 13701193 O3K_15700 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779816.1 3197878 R 1133852 CDS YP_006779817.1 407482668 13701194 complement(3198356..3199906) 1 NC_018658.1 hypothetical protein 3199906 13701194 O3K_15705 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779817.1 3198356 R 1133852 CDS YP_006779818.1 407482669 13701195 3201455..3201889 1 NC_018658.1 COG1080 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria); hypothetical protein 3201889 13701195 O3K_15710 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779818.1 3201455 D 1133852 CDS YP_006779819.1 407482670 13701196 3202042..3203022 1 NC_018658.1 COG3039 Transposase and inactivated derivatives, IS5 family; transposase 3203022 13701196 O3K_15715 Escherichia coli O104:H4 str. 2011C-3493 transposase YP_006779819.1 3202042 D 1133852 CDS YP_006779820.1 407482671 13701197 complement(3204058..3204285) 1 NC_018658.1 hypothetical protein 3204285 13701197 O3K_15720 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779820.1 3204058 R 1133852 CDS YP_006779821.1 407482672 13701198 3204321..3204902 1 NC_018658.1 COG2382 Enterochelin esterase and related enzymes; ferric enterochelin esterase 3204902 13701198 O3K_15725 Escherichia coli O104:H4 str. 2011C-3493 ferric enterochelin esterase YP_006779821.1 3204321 D 1133852 CDS YP_006779822.1 407482673 13701199 complement(3205044..3206168) 1 NC_018658.1 COG1819 Glycosyl transferases, related to UDP-glucuronosyltransferase; putative glucosyl-transferase 3206168 13701199 O3K_15730 Escherichia coli O104:H4 str. 2011C-3493 putative glucosyl-transferase YP_006779822.1 3205044 R 1133852 CDS YP_006779823.1 407482674 13701200 complement(3206898..3207095) 1 NC_018658.1 COG3311 Predicted transcriptional regulator; putative DNA binding protein 3207095 13701200 O3K_15735 Escherichia coli O104:H4 str. 2011C-3493 putative DNA binding protein YP_006779823.1 3206898 R 1133852 CDS YP_006779824.1 407482675 13701201 complement(3207161..3207355) 1 NC_018658.1 hypothetical protein 3207355 13701201 O3K_15740 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779824.1 3207161 R 1133852 CDS YP_006779825.1 407482676 13701202 3207577..3207660 1 NC_018658.1 hypothetical protein 3207660 13701202 O3K_15745 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779825.1 3207577 D 1133852 CDS YP_006779826.1 407482677 13701203 3208257..3208451 1 NC_018658.1 hypothetical protein 3208451 13701203 O3K_15750 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779826.1 3208257 D 1133852 CDS YP_006779827.1 407482678 13701204 3208812..3208940 1 NC_018658.1 COG2801 Transposase and inactivated derivatives; hypothetical protein 3208940 13701204 O3K_15755 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779827.1 3208812 D 1133852 CDS YP_006779828.1 407482679 13701205 complement(3209422..3209586) 1 NC_018658.1 hypothetical protein 3209586 13701205 O3K_15760 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779828.1 3209422 R 1133852 CDS YP_006779829.1 407482680 13701206 complement(3210220..3210438) 1 NC_018658.1 hypothetical protein 3210438 13701206 O3K_15765 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779829.1 3210220 R 1133852 CDS YP_006779830.1 407482681 13701207 complement(3211770..3211952) 1 NC_018658.1 hypothetical protein 3211952 13701207 O3K_15770 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779830.1 3211770 R 1133852 CDS YP_006779831.1 407482682 13701208 3211891..3213981 1 NC_018658.1 COG4771 Outer membrane receptor for ferrienterochelin and colicins; bifunctional enterobactin receptor/adhesin protein 3213981 13701208 O3K_15775 Escherichia coli O104:H4 str. 2011C-3493 bifunctional enterobactin receptor/adhesin protein YP_006779831.1 3211891 D 1133852 CDS YP_006779832.1 407482683 13701209 3214215..3214439 1 NC_018658.1 hypothetical protein 3214439 13701209 O3K_15780 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779832.1 3214215 D 1133852 CDS YP_006779833.1 407482684 13701210 3214677..3215081 1 NC_018658.1 COG2963 Transposase and inactivated derivatives; ISSfl3 protein 3215081 13701210 O3K_15785 Escherichia coli O104:H4 str. 2011C-3493 ISSfl3 protein YP_006779833.1 3214677 D 1133852 CDS YP_006779834.1 407482685 13701211 3215078..3215425 1 NC_018658.1 COG3436 Transposase and inactivated derivatives; IS66 family element 3215425 13701211 O3K_15790 Escherichia coli O104:H4 str. 2011C-3493 IS66 family element YP_006779834.1 3215078 D 1133852 CDS YP_006779835.1 407482686 13701212 3216669..3216857 1 NC_018658.1 hypothetical protein 3216857 13701212 O3K_15805 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779835.1 3216669 D 1133852 CDS YP_006779836.1 407482687 13701213 complement(3216875..3219235) 1 NC_018658.1 COG4951 Uncharacterized protein conserved in bacteria; helicase 3219235 13701213 O3K_15810 Escherichia coli O104:H4 str. 2011C-3493 helicase YP_006779836.1 3216875 R 1133852 CDS YP_006779837.1 407482688 13701214 complement(3219390..3219953) 1 NC_018658.1 hypothetical protein 3219953 13701214 O3K_15815 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779837.1 3219390 R 1133852 CDS YP_006779838.1 407482689 13701215 complement(3221289..3223124) 1 NC_018658.1 hypothetical protein 3223124 13701215 O3K_15820 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779838.1 3221289 R 1133852 CDS YP_006779839.1 407482690 13701216 3223225..3223512 1 NC_018658.1 COG3311 Predicted transcriptional regulator; putative regulatory protein 3223512 13701216 O3K_15825 Escherichia coli O104:H4 str. 2011C-3493 putative regulatory protein YP_006779839.1 3223225 D 1133852 CDS YP_006779840.1 407482691 13701217 3223487..3225013 1 NC_018658.1 hypothetical protein 3225013 13701217 O3K_15830 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779840.1 3223487 D 1133852 CDS YP_006779841.1 407482692 13701218 complement(3225183..3226400) 1 NC_018658.1 COG0582 Integrase; integrase 3226400 13701218 O3K_15835 Escherichia coli O104:H4 str. 2011C-3493 integrase YP_006779841.1 3225183 R 1133852 CDS YP_006779842.1 407482693 13701219 complement(3226948..3227934) 1 NC_018658.1 inner membrane protein 3227934 13701219 O3K_15840 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006779842.1 3226948 R 1133852 CDS YP_006779843.1 407482694 13701220 complement(3227931..3228422) 1 NC_018658.1 COG0331 (acyl-carrier-protein) S-malonyltransferase; hypothetical protein 3228422 13701220 O3K_15845 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779843.1 3227931 R 1133852 CDS YP_006779844.1 407482695 13701221 3228525..3228824 1 NC_018658.1 COG2963 Transposase and inactivated derivatives; IS3 element protein InsE 3228824 13701221 O3K_15850 Escherichia coli O104:H4 str. 2011C-3493 IS3 element protein InsE YP_006779844.1 3228525 D 1133852 CDS YP_006779845.1 407482696 13701222 3228821..3229687 1 NC_018658.1 COG2801 Transposase and inactivated derivatives; transposase 3229687 13701222 O3K_15855 Escherichia coli O104:H4 str. 2011C-3493 transposase YP_006779845.1 3228821 D 1133852 CDS YP_006779846.1 407482697 13701223 complement(3229728..3231086) 1 NC_018658.1 COG2199 FOG: GGDEF domain; diguanylate cyclase 3231086 13701223 O3K_15860 Escherichia coli O104:H4 str. 2011C-3493 diguanylate cyclase YP_006779846.1 3229728 R 1133852 CDS YP_006779847.1 407482698 13701224 3231673..3234096 1 NC_018658.1 COG0457 FOG: TPR repeat; outer membrane protein PgaA 3234096 pgaA 13701224 pgaA Escherichia coli O104:H4 str. 2011C-3493 outer membrane protein PgaA YP_006779847.1 3231673 D 1133852 CDS YP_006779848.1 407482699 13701225 3234105..3236123 1 NC_018658.1 COG0726 Predicted xylanase/chitin deacetylase; outer membrane N-deacetylase 3236123 pgaB 13701225 pgaB Escherichia coli O104:H4 str. 2011C-3493 outer membrane N-deacetylase YP_006779848.1 3234105 D 1133852 CDS YP_006779849.1 407482700 13701226 3236116..3237441 1 NC_018658.1 COG1215 Glycosyltransferases, probably involved in cell wall biogenesis; N-glycosyltransferase 3237441 13701226 O3K_15875 Escherichia coli O104:H4 str. 2011C-3493 N-glycosyltransferase YP_006779849.1 3236116 D 1133852 CDS YP_006779850.1 407482701 13701227 3237443..3237856 1 NC_018658.1 putative PGA biosynthesis protein 3237856 pgaD 13701227 pgaD Escherichia coli O104:H4 str. 2011C-3493 putative PGA biosynthesis protein YP_006779850.1 3237443 D 1133852 CDS YP_006779851.1 407482702 13701228 complement(3237906..3238694) 1 NC_018658.1 COG1702 Phosphate starvation-inducible protein PhoH, predicted ATPase; hypothetical protein 3238694 13701228 O3K_15885 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779851.1 3237906 R 1133852 CDS YP_006779852.1 407482703 13701229 complement(3239313..3240584) 1 NC_018658.1 COG2837 Predicted iron-dependent peroxidase; hypothetical protein 3240584 13701229 O3K_15890 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779852.1 3239313 R 1133852 CDS YP_006779853.1 407482704 13701230 complement(3240590..3241717) 1 NC_018658.1 COG2822 Predicted periplasmic lipoprotein involved in iron transport; inactive ferrous ion transporter periplasmic protein EfeO 3241717 13701230 O3K_15895 Escherichia coli O104:H4 str. 2011C-3493 inactive ferrous ion transporter periplasmic protein EfeO YP_006779853.1 3240590 R 1133852 CDS YP_006779854.1 407482705 13701231 complement(3241775..3242605) 1 NC_018658.1 COG0672 High-affinity Fe2+/Pb2+ permease; putative high-affinity Fe2+/Pb2+ permease 3242605 13701231 O3K_15900 Escherichia coli O104:H4 str. 2011C-3493 putative high-affinity Fe2+/Pb2+ permease YP_006779854.1 3241775 R 1133852 CDS YP_006779855.1 407482706 13701232 complement(3243147..3244655) 1 NC_018658.1 COG0591 Na+/proline symporter; proline:sodium symporter PutP 3244655 13701232 O3K_15905 Escherichia coli O104:H4 str. 2011C-3493 proline:sodium symporter PutP YP_006779855.1 3243147 R 1133852 CDS YP_006779856.1 407482707 13701233 complement(3244814..3245023) 1 NC_018658.1 hypothetical protein 3245023 13701233 O3K_15910 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779856.1 3244814 R 1133852 CDS YP_006779857.1 407482708 13701234 3245078..3249040 1 NC_018658.1 COG0506 Proline dehydrogenase; multifunctional functional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 3249040 putA 13701234 putA Escherichia coli O104:H4 str. 2011C-3493 multifunctional functional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase YP_006779857.1 3245078 D 1133852 CDS YP_006779858.1 407482709 13701235 complement(3249080..3249718) 1 NC_018658.1 COG1309 Transcriptional regulator; HTH-type transcriptional regulator RutR 3249718 13701235 O3K_15920 Escherichia coli O104:H4 str. 2011C-3493 HTH-type transcriptional regulator RutR YP_006779858.1 3249080 R 1133852 CDS YP_006779859.1 407482710 13701236 3250006..3251097 1 NC_018658.1 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases; monooxygenase of the alternative pyrimidine degradation pathway 3251097 13701236 O3K_15925 Escherichia coli O104:H4 str. 2011C-3493 monooxygenase of the alternative pyrimidine degradation pathway YP_006779859.1 3250006 D 1133852 CDS YP_006779860.1 407482711 13701237 3251097..3251789 1 NC_018658.1 COG1335 Amidases related to nicotinamidase; hypothetical protein 3251789 13701237 O3K_15930 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779860.1 3251097 D 1133852 CDS YP_006779861.1 407482712 13701238 3251801..3252187 1 NC_018658.1 COG0251 Putative translation initiation inhibitor, yjgF family; hypothetical protein 3252187 13701238 O3K_15935 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779861.1 3251801 D 1133852 CDS YP_006779862.1 407482713 13701239 3252195..3252995 1 NC_018658.1 COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily); enzyme of the alternative pyrimidine degradation pathway 3252995 13701239 O3K_15940 Escherichia coli O104:H4 str. 2011C-3493 enzyme of the alternative pyrimidine degradation pathway YP_006779862.1 3252195 D 1133852 CDS YP_006779863.1 407482714 13701240 3253005..3253595 1 NC_018658.1 COG0778 Nitroreductase; malonic semialdehyde reductase 3253595 13701240 O3K_15945 Escherichia coli O104:H4 str. 2011C-3493 malonic semialdehyde reductase YP_006779863.1 3253005 D 1133852 CDS YP_006779864.1 407482715 13701241 3253606..3254100 1 NC_018658.1 COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family; flavin:NADH oxidoreductase subunit of alternative pyrimidine degradation pathway 3254100 13701241 O3K_15950 Escherichia coli O104:H4 str. 2011C-3493 flavin:NADH oxidoreductase subunit of alternative pyrimidine degradation pathway YP_006779864.1 3253606 D 1133852 CDS YP_006779865.1 407482716 13701242 3254121..3255449 1 NC_018658.1 COG2233 Xanthine/uracil permeases; transporter 3255449 13701242 O3K_15955 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006779865.1 3254121 D 1133852 CDS YP_006779866.1 407482717 13701243 complement(3255532..3255705) 1 NC_018658.1 COG3729 General stress protein; hypothetical protein 3255705 13701243 O3K_15960 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779866.1 3255532 R 1133852 CDS YP_006779868.1 407482719 13701245 complement(3256637..3265018) 1 NC_018658.1 hypothetical protein 3265018 13701245 O3K_15970 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779868.1 3256637 R 1133852 CDS YP_006779869.1 407482720 13701246 complement(3265088..3266353) 1 NC_018658.1 hypothetical protein 3266353 13701246 O3K_15975 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779869.1 3265088 R 1133852 CDS YP_006779870.1 407482721 13701247 complement(3266364..3266615) 1 NC_018658.1 hypothetical protein 3266615 13701247 O3K_15980 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779870.1 3266364 R 1133852 CDS YP_006779871.1 407482722 13701248 complement(3266625..3267071) 1 NC_018658.1 hypothetical protein 3267071 13701248 O3K_15985 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779871.1 3266625 R 1133852 CDS YP_006779872.1 407482723 13701249 complement(3267074..3267730) 1 NC_018658.1 hypothetical protein 3267730 13701249 O3K_15990 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779872.1 3267074 R 1133852 CDS YP_006779873.1 407482724 13701250 complement(3267824..3268225) 1 NC_018658.1 hypothetical protein 3268225 13701250 O3K_15995 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779873.1 3267824 R 1133852 CDS YP_006779874.1 407482725 13701251 complement(3268282..3268422) 1 NC_018658.1 hypothetical protein 3268422 13701251 O3K_16000 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779874.1 3268282 R 1133852 CDS YP_006779875.1 407482726 13701252 complement(3268655..3269389) 1 NC_018658.1 putative outer membrane protein Lom 3269389 13701252 O3K_16005 Escherichia coli O104:H4 str. 2011C-3493 putative outer membrane protein Lom YP_006779875.1 3268655 R 1133852 CDS YP_006779876.1 407482727 13701253 complement(3269480..3270097) 1 NC_018658.1 hypothetical protein 3270097 13701253 O3K_16010 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779876.1 3269480 R 1133852 CDS YP_006779877.1 407482728 13701254 complement(3270103..3270381) 1 NC_018658.1 putative outer membrane protein 3270381 13701254 O3K_16015 Escherichia coli O104:H4 str. 2011C-3493 putative outer membrane protein YP_006779877.1 3270103 R 1133852 CDS YP_006779878.1 407482729 13701255 complement(3270396..3271664) 1 NC_018658.1 COG4733 Phage-related protein, tail component; putative tail tip fiber protein 3271664 13701255 O3K_16020 Escherichia coli O104:H4 str. 2011C-3493 putative tail tip fiber protein YP_006779878.1 3270396 R 1133852 CDS YP_006779879.1 407482730 13701256 complement(3271661..3273352) 1 NC_018658.1 hypothetical protein 3273352 13701256 O3K_16025 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779879.1 3271661 R 1133852 CDS YP_006779880.1 407482731 13701257 complement(3273520..3274032) 1 NC_018658.1 hypothetical protein 3274032 13701257 O3K_16030 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779880.1 3273520 R 1133852 CDS YP_006779881.1 407482732 13701258 complement(3274119..3276311) 1 NC_018658.1 putative tail fiber protein 3276311 13701258 O3K_16035 Escherichia coli O104:H4 str. 2011C-3493 putative tail fiber protein YP_006779881.1 3274119 R 1133852 CDS YP_006779882.1 407482733 13701259 complement(3276308..3276958) 1 NC_018658.1 hypothetical protein 3276958 13701259 O3K_16040 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779882.1 3276308 R 1133852 CDS YP_006779883.1 407482734 13701260 complement(3276958..3277521) 1 NC_018658.1 hypothetical protein 3277521 13701260 O3K_16045 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779883.1 3276958 R 1133852 CDS YP_006779884.1 407482735 13701261 complement(3277505..3277966) 1 NC_018658.1 hypothetical protein 3277966 13701261 O3K_16050 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779884.1 3277505 R 1133852 CDS YP_006779885.1 407482736 13701262 complement(3278016..3278405) 1 NC_018658.1 hypothetical protein 3278405 13701262 O3K_16055 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779885.1 3278016 R 1133852 CDS YP_006779886.1 407482737 13701263 complement(3278461..3279675) 1 NC_018658.1 hypothetical protein 3279675 13701263 O3K_16060 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779886.1 3278461 R 1133852 CDS YP_006779887.1 407482738 13701264 complement(3279699..3280706) 1 NC_018658.1 hypothetical protein 3280706 13701264 O3K_16065 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779887.1 3279699 R 1133852 CDS YP_006779888.1 407482739 13701265 complement(3280864..3283008) 1 NC_018658.1 putative portal protein 3283008 13701265 O3K_16070 Escherichia coli O104:H4 str. 2011C-3493 putative portal protein YP_006779888.1 3280864 R 1133852 CDS YP_006779889.1 407482740 13701266 complement(3283008..3284714) 1 NC_018658.1 terminase large subunit 3284714 13701266 O3K_16075 Escherichia coli O104:H4 str. 2011C-3493 terminase large subunit YP_006779889.1 3283008 R 1133852 CDS YP_006779890.1 407482741 13701267 complement(3284695..3285501) 1 NC_018658.1 putative small subunit terminase 3285501 13701267 O3K_16080 Escherichia coli O104:H4 str. 2011C-3493 putative small subunit terminase YP_006779890.1 3284695 R 1133852 CDS YP_006779891.1 407482742 13701268 complement(3285794..3286345) 1 NC_018658.1 COG3646 Uncharacterized phage-encoded protein; putative phage protein Rha 3286345 13701268 O3K_16085 Escherichia coli O104:H4 str. 2011C-3493 putative phage protein Rha YP_006779891.1 3285794 R 1133852 CDS YP_006779892.1 407482743 13701269 complement(3286548..3286976) 1 NC_018658.1 endopeptidase (Protein gp15) 3286976 13701269 O3K_16090 Escherichia coli O104:H4 str. 2011C-3493 endopeptidase (Protein gp15) YP_006779892.1 3286548 R 1133852 CDS YP_006779893.1 407482744 13701270 complement(3286988..3287122) 1 NC_018658.1 hypothetical protein 3287122 13701270 O3K_16095 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779893.1 3286988 R 1133852 CDS YP_006779894.1 407482745 13701271 complement(3287137..3287706) 1 NC_018658.1 putative antirepressor 3287706 13701271 O3K_16100 Escherichia coli O104:H4 str. 2011C-3493 putative antirepressor YP_006779894.1 3287137 R 1133852 CDS YP_006779895.1 407482746 13701272 complement(3287980..3288513) 1 NC_018658.1 COG3772 Phage-related lysozyme (muraminidase); putative endolysin 3288513 13701272 O3K_16105 Escherichia coli O104:H4 str. 2011C-3493 putative endolysin YP_006779895.1 3287980 R 1133852 CDS YP_006779896.1 407482747 13701273 complement(3288518..3288733) 1 NC_018658.1 lysis protein 3288733 13701273 O3K_16110 Escherichia coli O104:H4 str. 2011C-3493 lysis protein YP_006779896.1 3288518 R 1133852 CDS YP_006779897.1 407482748 13701274 complement(3288811..3289056) 1 NC_018658.1 hypothetical protein 3289056 13701274 O3K_16115 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779897.1 3288811 R 1133852 CDS YP_006779898.1 407482749 13701275 complement(3289097..3289276) 1 NC_018658.1 hypothetical protein 3289276 13701275 O3K_16120 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779898.1 3289097 R 1133852 CDS YP_006779899.1 407482750 13701276 complement(3289413..3291350) 1 NC_018658.1 hypothetical protein 3291350 13701276 O3K_16125 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779899.1 3289413 R 1133852 CDS YP_006779900.1 407482751 13701277 complement(3291836..3292105) 1 NC_018658.1 Shiga toxin 2 subunit B 3292105 13701277 O3K_16130 Escherichia coli O104:H4 str. 2011C-3493 Shiga toxin 2 subunit B YP_006779900.1 3291836 R 1133852 CDS YP_006779901.1 407482752 13701278 complement(3292117..3293076) 1 NC_018658.1 Shiga toxin 2 subunit A 3293076 13701278 O3K_16135 Escherichia coli O104:H4 str. 2011C-3493 Shiga toxin 2 subunit A YP_006779901.1 3292117 R 1133852 CDS YP_006779902.1 407482753 13701282 complement(3293459..3293557) 1 NC_018658.1 DNA adenine methyltransferase encoded by prophage 3293557 13701282 O3K_16140 Escherichia coli O104:H4 str. 2011C-3493 DNA adenine methyltransferase encoded by prophage YP_006779902.1 3293459 R 1133852 CDS YP_006779903.1 407482754 13701283 complement(3293860..3294294) 1 NC_018658.1 putative antitermination protein Q 3294294 13701283 O3K_16145 Escherichia coli O104:H4 str. 2011C-3493 putative antitermination protein Q YP_006779903.1 3293860 R 1133852 CDS YP_006779904.1 407482755 13701284 complement(3294287..3294481) 1 NC_018658.1 hypothetical protein 3294481 13701284 O3K_16150 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779904.1 3294287 R 1133852 CDS YP_006779905.1 407482756 13701285 complement(3294478..3295041) 1 NC_018658.1 hypothetical protein 3295041 13701285 O3K_16155 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779905.1 3294478 R 1133852 CDS YP_006779906.1 407482757 13701286 complement(3295049..3295498) 1 NC_018658.1 hypothetical protein 3295498 13701286 O3K_16160 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779906.1 3295049 R 1133852 CDS YP_006779907.1 407482758 13701287 complement(3295498..3296469) 1 NC_018658.1 DNA primase 3296469 13701287 O3K_16165 Escherichia coli O104:H4 str. 2011C-3493 DNA primase YP_006779907.1 3295498 R 1133852 CDS YP_006779908.1 407482759 13701288 complement(3296459..3297979) 1 NC_018658.1 COG1061 DNA or RNA helicases of superfamily II; helicase 3297979 13701288 O3K_16170 Escherichia coli O104:H4 str. 2011C-3493 helicase YP_006779908.1 3296459 R 1133852 CDS YP_006779909.1 407482760 13701289 complement(3297973..3298350) 1 NC_018658.1 COG3480 Predicted secreted protein containing a PDZ domain; hypothetical protein 3298350 13701289 O3K_16175 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779909.1 3297973 R 1133852 CDS YP_006779910.1 407482761 13701290 complement(3298558..3298851) 1 NC_018658.1 hypothetical protein 3298851 13701290 O3K_16180 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779910.1 3298558 R 1133852 CDS YP_006779911.1 407482762 13701291 complement(3298882..3299085) 1 NC_018658.1 hypothetical protein 3299085 13701291 O3K_16185 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779911.1 3298882 R 1133852 CDS YP_006779912.1 407482763 13701292 3299181..3299894 1 NC_018658.1 COG2932 Predicted transcriptional regulator; repressor protein CI 3299894 13701292 O3K_16190 Escherichia coli O104:H4 str. 2011C-3493 repressor protein CI YP_006779912.1 3299181 D 1133852 CDS YP_006779913.1 407482764 13701293 3299989..3301458 1 NC_018658.1 COG0286 Type I restriction-modification system methyltransferase subunit; site-specific DNA-methyltransferase 3301458 13701293 O3K_16195 Escherichia coli O104:H4 str. 2011C-3493 site-specific DNA-methyltransferase YP_006779913.1 3299989 D 1133852 CDS YP_006779914.1 407482765 13701294 3301455..3302408 1 NC_018658.1 type II site-specific deoxyribonuclease 3302408 13701294 O3K_16200 Escherichia coli O104:H4 str. 2011C-3493 type II site-specific deoxyribonuclease YP_006779914.1 3301455 D 1133852 CDS YP_006779915.1 407482766 13701295 3303037..3303810 1 NC_018658.1 COG3646 Uncharacterized phage-encoded protein; hypothetical protein 3303810 13701295 O3K_16205 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779915.1 3303037 D 1133852 CDS YP_006779916.1 407482767 13701296 3304267..3304740 1 NC_018658.1 anti-termination protein 3304740 13701296 O3K_16210 Escherichia coli O104:H4 str. 2011C-3493 anti-termination protein YP_006779916.1 3304267 D 1133852 CDS YP_006779917.1 407482768 13701297 3304811..3305023 1 NC_018658.1 host killing protein 3305023 13701297 O3K_16215 Escherichia coli O104:H4 str. 2011C-3493 host killing protein YP_006779917.1 3304811 D 1133852 CDS YP_006779918.1 407482769 13701298 3305095..3305316 1 NC_018658.1 hypothetical protein 3305316 13701298 O3K_16220 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779918.1 3305095 D 1133852 CDS YP_006779919.1 407482770 13701299 3305337..3305618 1 NC_018658.1 hypothetical protein 3305618 13701299 O3K_16225 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779919.1 3305337 D 1133852 CDS YP_006779920.1 407482771 13701300 3305635..3306585 1 NC_018658.1 COG3723 Recombinational DNA repair protein (RecE pathway); DNA recombination protein Bet 3306585 13701300 O3K_16230 Escherichia coli O104:H4 str. 2011C-3493 DNA recombination protein Bet YP_006779920.1 3305635 D 1133852 CDS YP_006779921.1 407482772 13701301 3306582..3307271 1 NC_018658.1 COG4615 ABC-type siderophore export system, fused ATPase and permease components; exonuclease 3307271 13701301 O3K_16235 Escherichia coli O104:H4 str. 2011C-3493 exonuclease YP_006779921.1 3306582 D 1133852 CDS YP_006779922.1 407482773 13701302 3307271..3307858 1 NC_018658.1 hypothetical protein 3307858 13701302 O3K_16240 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779922.1 3307271 D 1133852 CDS YP_006779923.1 407482774 13701303 3307933..3308280 1 NC_018658.1 hypothetical protein 3308280 13701303 O3K_16245 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779923.1 3307933 D 1133852 CDS YP_006779924.1 407482775 13701304 3308344..3309165 1 NC_018658.1 COG5532 Uncharacterized conserved protein; hypothetical protein 3309165 13701304 O3K_16250 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779924.1 3308344 D 1133852 CDS YP_006779925.1 407482776 13701305 3309242..3309637 1 NC_018658.1 hypothetical protein 3309637 13701305 O3K_16255 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779925.1 3309242 D 1133852 CDS YP_006779926.1 407482777 13701306 3309788..3310513 1 NC_018658.1 hypothetical protein 3310513 13701306 O3K_16260 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779926.1 3309788 D 1133852 CDS YP_006779927.1 407482778 13701307 3310510..3310917 1 NC_018658.1 hypothetical protein 3310917 13701307 O3K_16265 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779927.1 3310510 D 1133852 CDS YP_006779928.1 407482779 13701308 3310919..3311110 1 NC_018658.1 hypothetical protein 3311110 13701308 O3K_16270 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779928.1 3310919 D 1133852 CDS YP_006779929.1 407482780 13701309 3311113..3312009 1 NC_018658.1 hypothetical protein 3312009 13701309 O3K_16275 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779929.1 3311113 D 1133852 CDS YP_006779930.1 407482781 13701310 3312002..3312100 1 NC_018658.1 hypothetical protein 3312100 13701310 O3K_16280 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779930.1 3312002 D 1133852 CDS YP_006779931.1 407482782 13701311 3312365..3313003 1 NC_018658.1 COG3561 Phage anti-repressor protein; antirepressor 3313003 13701311 O3K_16285 Escherichia coli O104:H4 str. 2011C-3493 antirepressor YP_006779931.1 3312365 D 1133852 CDS YP_006779932.1 407482783 13701312 3313059..3313490 1 NC_018658.1 regulatory protein 3313490 13701312 O3K_16290 Escherichia coli O104:H4 str. 2011C-3493 regulatory protein YP_006779932.1 3313059 D 1133852 CDS YP_006779933.1 407482784 13701313 3313487..3314113 1 NC_018658.1 COG4725 Transcriptional activator, adenine-specific DNA methyltransferase; adenine methylase 3314113 13701313 O3K_16295 Escherichia coli O104:H4 str. 2011C-3493 adenine methylase YP_006779933.1 3313487 D 1133852 CDS YP_006779934.1 407482785 13701314 3314073..3314285 1 NC_018658.1 hypothetical protein 3314285 13701314 O3K_16300 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779934.1 3314073 D 1133852 CDS YP_006779935.1 407482786 13701315 3314321..3314674 1 NC_018658.1 hypothetical protein 3314674 13701315 O3K_16305 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779935.1 3314321 D 1133852 CDS YP_006779936.1 407482787 13701316 3315039..3315290 1 NC_018658.1 hypothetical protein 3315290 13701316 O3K_16310 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779936.1 3315039 D 1133852 CDS YP_006779937.1 407482788 13701317 3315321..3315620 1 NC_018658.1 putative excisionase 3315620 13701317 O3K_16315 Escherichia coli O104:H4 str. 2011C-3493 putative excisionase YP_006779937.1 3315321 D 1133852 CDS YP_006779938.1 407482789 13701318 3315673..3316983 1 NC_018658.1 COG0582 Integrase; integrase 3316983 13701318 O3K_16320 Escherichia coli O104:H4 str. 2011C-3493 integrase YP_006779938.1 3315673 D 1133852 CDS YP_006779939.1 407482790 13701319 3317013..3317558 1 NC_018658.1 COG0655 Multimeric flavodoxin WrbA; NAD(P)H:quinone oxidoreductase 3317558 13701319 O3K_16325 Escherichia coli O104:H4 str. 2011C-3493 NAD(P)H:quinone oxidoreductase YP_006779939.1 3317013 D 1133852 CDS YP_006779940.1 407482791 13701320 3317579..3317806 1 NC_018658.1 hypothetical protein 3317806 13701320 O3K_16330 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779940.1 3317579 D 1133852 CDS YP_006779941.1 407482792 13701321 complement(3317844..3319085) 1 NC_018658.1 glucose-1-phosphatase/inositol phosphatase 3319085 13701321 O3K_16335 Escherichia coli O104:H4 str. 2011C-3493 glucose-1-phosphatase/inositol phosphatase YP_006779941.1 3317844 R 1133852 CDS YP_006779942.1 407482793 13701322 complement(3319374..3320561) 1 NC_018658.1 hypothetical protein 3320561 13701322 O3K_16340 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779942.1 3319374 R 1133852 CDS YP_006779943.1 407482794 13701323 3320894..3321814 1 NC_018658.1 COG2214 DnaJ-class molecular chaperone; curved DNA-binding protein CbpA 3321814 13701323 O3K_16345 Escherichia coli O104:H4 str. 2011C-3493 curved DNA-binding protein CbpA YP_006779943.1 3320894 D 1133852 CDS YP_006779944.1 407482795 13701324 3321814..3322119 1 NC_018658.1 chaperone-modulator protein CbpM 3322119 13701324 O3K_16350 Escherichia coli O104:H4 str. 2011C-3493 chaperone-modulator protein CbpM YP_006779944.1 3321814 D 1133852 CDS YP_006779945.1 407482796 13701325 complement(3322212..3322811) 1 NC_018658.1 COG3381 Uncharacterized component of anaerobic dehydrogenases; chaperone protein TorD 3322811 torD 13701325 torD Escherichia coli O104:H4 str. 2011C-3493 chaperone protein TorD YP_006779945.1 3322212 R 1133852 CDS YP_006779946.1 407482797 13701326 complement(3322808..3325354) 1 NC_018658.1 COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; trimethylamine N-oxide reductase I catalytic subunit 3325354 13701326 O3K_16360 Escherichia coli O104:H4 str. 2011C-3493 trimethylamine N-oxide reductase I catalytic subunit YP_006779946.1 3322808 R 1133852 CDS YP_006779947.1 407482798 13701327 complement(3325354..3326526) 1 NC_018658.1 COG3005 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit; trimethylamine N-oxide reductase cytochrome c-type subunit 3326526 13701327 O3K_16365 Escherichia coli O104:H4 str. 2011C-3493 trimethylamine N-oxide reductase cytochrome c-type subunit YP_006779947.1 3325354 R 1133852 CDS YP_006779948.1 407482799 13701328 3326656..3327348 1 NC_018658.1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; DNA-binding transcriptional regulator TorR 3327348 13701328 O3K_16370 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator TorR YP_006779948.1 3326656 D 1133852 CDS YP_006779949.1 407482800 13701329 complement(3327321..3328349) 1 NC_018658.1 COG1879 ABC-type sugar transport system, periplasmic component; TMAO reductase system periplasmic protein TorT 3328349 13701329 O3K_16375 Escherichia coli O104:H4 str. 2011C-3493 TMAO reductase system periplasmic protein TorT YP_006779949.1 3327321 R 1133852 CDS YP_006779950.1 407482801 13701330 3328432..3331176 1 NC_018658.1 COG0642 Signal transduction histidine kinase; hybrid sensory histidine kinase TorS 3331176 13701330 O3K_16380 Escherichia coli O104:H4 str. 2011C-3493 hybrid sensory histidine kinase TorS YP_006779950.1 3328432 D 1133852 CDS YP_006779951.1 407482802 13701331 3331248..3332321 1 NC_018658.1 COG0348 Polyferredoxin; 4Fe-4S binding protein 3332321 13701331 O3K_16385 Escherichia coli O104:H4 str. 2011C-3493 4Fe-4S binding protein YP_006779951.1 3331248 D 1133852 CDS YP_006779952.1 407482803 13701332 complement(3332370..3332543) 1 NC_018658.1 putative regulator of phosphatidylethanolamine synthesis 3332543 13701332 O3K_16390 Escherichia coli O104:H4 str. 2011C-3493 putative regulator of phosphatidylethanolamine synthesis YP_006779952.1 3332370 R 1133852 CDS YP_006779953.1 407482804 13701333 complement(3332533..3332763) 1 NC_018658.1 putative protein sfa; cold shock protein 3332763 13701333 O3K_16395 Escherichia coli O104:H4 str. 2011C-3493 cold shock protein YP_006779953.1 3332533 R 1133852 CDS YP_006779954.1 407482805 13701334 complement(3332937..3333149) 1 NC_018658.1 COG1278 Cold shock proteins; cold shock protein CspG 3333149 13701334 O3K_16400 Escherichia coli O104:H4 str. 2011C-3493 cold shock protein CspG YP_006779954.1 3332937 R 1133852 CDS YP_006779955.1 407482806 13701335 3333435..3333647 1 NC_018658.1 COG1278 Cold shock proteins; cold shock-like protein CspH 3333647 13701335 O3K_16405 Escherichia coli O104:H4 str. 2011C-3493 cold shock-like protein CspH YP_006779955.1 3333435 D 1133852 CDS YP_006779956.1 407482807 13701336 3334501..3335145 1 NC_018658.1 outer membrane lipoprotein 3335145 13701336 O3K_16410 Escherichia coli O104:H4 str. 2011C-3493 outer membrane lipoprotein YP_006779956.1 3334501 D 1133852 CDS YP_006779957.1 407482808 13701337 3335142..3335888 1 NC_018658.1 hypothetical protein 3335888 13701337 O3K_16415 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779957.1 3335142 D 1133852 CDS YP_006779958.1 407482809 13701338 3335888..3337984 1 NC_018658.1 hypothetical protein 3337984 13701338 O3K_16420 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779958.1 3335888 D 1133852 CDS YP_006779959.1 407482810 13701339 3338030..3339169 1 NC_018658.1 COG1596 Periplasmic protein involved in polysaccharide export; polysaccharide export protein Wza 3339169 13701339 O3K_16425 Escherichia coli O104:H4 str. 2011C-3493 polysaccharide export protein Wza YP_006779959.1 3338030 D 1133852 CDS YP_006779960.1 407482811 13701340 3339157..3339603 1 NC_018658.1 COG0394 Protein-tyrosine-phosphatase; phosphotyrosine-protein phosphatase 3339603 etp 13701340 etp Escherichia coli O104:H4 str. 2011C-3493 phosphotyrosine-protein phosphatase YP_006779960.1 3339157 D 1133852 CDS YP_006779961.1 407482812 13701341 3339623..3341803 1 NC_018658.1 COG3206 Uncharacterized protein involved in exopolysaccharide biosynthesis; cryptic autophosphorylating protein tyrosine kinase Etk 3341803 13701341 O3K_16435 Escherichia coli O104:H4 str. 2011C-3493 cryptic autophosphorylating protein tyrosine kinase Etk YP_006779961.1 3339623 D 1133852 CDS YP_006779962.1 407482813 13701342 complement(3341918..3343216) 1 NC_018658.1 phosphoanhydride phosphorylase 3343216 13701342 O3K_16440 Escherichia coli O104:H4 str. 2011C-3493 phosphoanhydride phosphorylase YP_006779962.1 3341918 R 1133852 CDS YP_006779963.1 407482814 13701343 complement(3343296..3343388) 1 NC_018658.1 hypothetical protein 3343388 13701343 O3K_16445 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779963.1 3343296 R 1133852 CDS YP_006779964.1 407482815 13701344 complement(3343401..3344537) 1 NC_018658.1 COG1294 Cytochrome bd-type quinol oxidase, subunit 2; cytochrome bd-II oxidase subunit 2 3344537 13701344 O3K_16450 Escherichia coli O104:H4 str. 2011C-3493 cytochrome bd-II oxidase subunit 2 YP_006779964.1 3343401 R 1133852 CDS YP_006779965.1 407482816 13701345 complement(3344549..3346093) 1 NC_018658.1 COG1271 Cytochrome bd-type quinol oxidase, subunit 1; cytochrome bd-II oxidase subunit 1 3346093 13701345 O3K_16455 Escherichia coli O104:H4 str. 2011C-3493 cytochrome bd-II oxidase subunit 1 YP_006779965.1 3344549 R 1133852 CDS YP_006779966.1 407482817 13701346 complement(3346227..3347084) 1 NC_018658.1 hydrogenase-1 operon protein HyaF 3347084 13701346 O3K_16460 Escherichia coli O104:H4 str. 2011C-3493 hydrogenase-1 operon protein HyaF YP_006779966.1 3346227 R 1133852 CDS YP_006779967.1 407482818 13701347 complement(3347081..3347479) 1 NC_018658.1 COG0526 Thiol-disulfide isomerase and thioredoxins; hydrogenase-1 operon protein HyaE 3347479 13701347 O3K_16465 Escherichia coli O104:H4 str. 2011C-3493 hydrogenase-1 operon protein HyaE YP_006779967.1 3347081 R 1133852 CDS YP_006779968.1 407482819 13701348 complement(3347476..3348063) 1 NC_018658.1 COG0680 Ni,Fe-hydrogenase maturation factor; hydrogenase 1 maturation protease 3348063 13701348 O3K_16470 Escherichia coli O104:H4 str. 2011C-3493 hydrogenase 1 maturation protease YP_006779968.1 3347476 R 1133852 CDS YP_006779969.1 407482820 13701349 complement(3348060..3348767) 1 NC_018658.1 COG1969 Ni,Fe-hydrogenase I cytochrome b subunit; hydrogenase 1 b-type cytochrome subunit 3348767 13701349 O3K_16475 Escherichia coli O104:H4 str. 2011C-3493 hydrogenase 1 b-type cytochrome subunit YP_006779969.1 3348060 R 1133852 CDS YP_006779970.1 407482821 13701350 complement(3348786..3350579) 1 NC_018658.1 COG0374 Ni,Fe-hydrogenase I large subunit; hydrogenase 1 large subunit 3350579 13701350 O3K_16480 Escherichia coli O104:H4 str. 2011C-3493 hydrogenase 1 large subunit YP_006779970.1 3348786 R 1133852 CDS YP_006779971.1 407482822 13701351 complement(3350576..3351694) 1 NC_018658.1 COG1740 Ni,Fe-hydrogenase I small subunit; hydrogenase 1, small subunit 3351694 13701351 O3K_16485 Escherichia coli O104:H4 str. 2011C-3493 hydrogenase 1, small subunit YP_006779971.1 3350576 R 1133852 CDS YP_006779972.1 407482823 13701353 3352415..3353074 1 NC_018658.1 COG0670 Integral membrane protein, interacts with FtsH; HflBKC-binding inner membrane protein 3353074 13701353 O3K_16490 Escherichia coli O104:H4 str. 2011C-3493 HflBKC-binding inner membrane protein YP_006779972.1 3352415 D 1133852 CDS YP_006779973.1 407482824 13701354 3353165..3353494 1 NC_018658.1 COG2920 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit; sulfur transfer protein TusE 3353494 13701354 O3K_16495 Escherichia coli O104:H4 str. 2011C-3493 sulfur transfer protein TusE YP_006779973.1 3353165 D 1133852 CDS YP_006779974.1 407482825 13701355 complement(3353491..3353769) 1 NC_018658.1 COG1254 Acylphosphatases; acylphosphatase 3353769 13701355 O3K_16500 Escherichia coli O104:H4 str. 2011C-3493 acylphosphatase YP_006779974.1 3353491 R 1133852 CDS YP_006779975.1 407482826 13701356 3353864..3355054 1 NC_018658.1 COG1092 Predicted SAM-dependent methyltransferases; 23S rRNA m(5)C1962 methyltransferase 3355054 13701356 O3K_16505 Escherichia coli O104:H4 str. 2011C-3493 23S rRNA m(5)C1962 methyltransferase YP_006779975.1 3353864 D 1133852 CDS YP_006779976.1 407482827 13701357 3355112..3355429 1 NC_018658.1 COG3785 Uncharacterized conserved protein; heat shock protein HspQ 3355429 13701357 O3K_16510 Escherichia coli O104:H4 str. 2011C-3493 heat shock protein HspQ YP_006779976.1 3355112 D 1133852 CDS YP_006779977.1 407482828 13701358 complement(3355474..3355887) 1 NC_018658.1 COG1832 Predicted CoA-binding protein; hypothetical protein 3355887 13701358 O3K_16515 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779977.1 3355474 R 1133852 CDS YP_006779978.1 407482829 13701359 3356060..3356722 1 NC_018658.1 COG3110 Uncharacterized protein conserved in bacteria; hypothetical protein 3356722 13701359 O3K_16520 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779978.1 3356060 D 1133852 CDS YP_006779979.1 407482830 13701360 3356818..3357276 1 NC_018658.1 COG1803 Methylglyoxal synthase; methylglyoxal synthase 3357276 mgsA 13701360 mgsA Escherichia coli O104:H4 str. 2011C-3493 methylglyoxal synthase YP_006779979.1 3356818 D 1133852 CDS YP_006779980.1 407482831 13701361 complement(3357308..3359362) 1 NC_018658.1 COG0210 Superfamily I DNA and RNA helicases; DNA helicase IV 3359362 helD 13701361 helD Escherichia coli O104:H4 str. 2011C-3493 DNA helicase IV YP_006779980.1 3357308 R 1133852 CDS YP_006779981.1 407482832 13701362 3359485..3359931 1 NC_018658.1 COG3304 Predicted membrane protein; hypothetical protein 3359931 13701362 O3K_16535 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779981.1 3359485 D 1133852 CDS YP_006779982.1 407482833 13701363 3359941..3362103 1 NC_018658.1 COG1289 Predicted membrane protein; hypothetical protein 3362103 13701363 O3K_16540 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779982.1 3359941 D 1133852 CDS YP_006779983.1 407482834 13701364 complement(3362066..3362695) 1 NC_018658.1 COG3070 Regulator of competence-specific genes; hypothetical protein 3362695 13701364 O3K_16545 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779983.1 3362066 R 1133852 CDS YP_006779984.1 407482835 13701365 3362914..3363423 1 NC_018658.1 COG5404 SOS-response cell division inhibitor, blocks FtsZ ring formation; SOS cell division inhibitor 3363423 13701365 O3K_16550 Escherichia coli O104:H4 str. 2011C-3493 SOS cell division inhibitor YP_006779984.1 3362914 D 1133852 CDS YP_006779985.1 407482836 13701366 3363780..3364820 1 NC_018658.1 COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins; outer membrane protein A 3364820 13701366 O3K_16555 Escherichia coli O104:H4 str. 2011C-3493 outer membrane protein A YP_006779985.1 3363780 D 1133852 CDS YP_006779986.1 407482837 13701367 complement(3364896..3365348) 1 NC_018658.1 COG3120 Uncharacterized protein conserved in bacteria; Ter macrodomain organizer matS-binding protein 3365348 13701367 O3K_16560 Escherichia coli O104:H4 str. 2011C-3493 Ter macrodomain organizer matS-binding protein YP_006779986.1 3364896 R 1133852 CDS YP_006779987.1 407482838 13701368 3365534..3367294 1 NC_018658.1 COG1067 Predicted ATP-dependent protease; peptidase, S16 (Lon protease) family protein 3367294 13701368 O3K_16565 Escherichia coli O104:H4 str. 2011C-3493 peptidase, S16 (Lon protease) family protein YP_006779987.1 3365534 D 1133852 CDS YP_006779988.1 407482839 13701369 3367363..3367881 1 NC_018658.1 COG0764 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases; 3-hydroxydecanoyl-ACP dehydratase 3367881 13701369 O3K_16570 Escherichia coli O104:H4 str. 2011C-3493 3-hydroxydecanoyl-ACP dehydratase YP_006779988.1 3367363 D 1133852 CDS YP_006779989.1 407482840 13701370 complement(3367951..3368118) 1 NC_018658.1 COG3130 Ribosome modulation factor; ribosome modulation factor 3368118 13701370 O3K_16575 Escherichia coli O104:H4 str. 2011C-3493 ribosome modulation factor YP_006779989.1 3367951 R 1133852 CDS YP_006779990.1 407482841 13701371 complement(3368374..3368937) 1 NC_018658.1 COG3009 Uncharacterized protein conserved in bacteria; lipoprotein 3368937 13701371 O3K_16580 Escherichia coli O104:H4 str. 2011C-3493 lipoprotein YP_006779990.1 3368374 R 1133852 CDS YP_006779991.1 407482842 13701372 complement(3368934..3370574) 1 NC_018658.1 COG3008 Paraquat-inducible protein B; paraquat-inducible protein B 3370574 13701372 O3K_16585 Escherichia coli O104:H4 str. 2011C-3493 paraquat-inducible protein B YP_006779991.1 3368934 R 1133852 CDS YP_006779992.1 407482843 13701373 complement(3370579..3371832) 1 NC_018658.1 COG2995 Uncharacterized paraquat-inducible protein A; paraquat-inducible membrane protein A 3371832 13701373 O3K_16590 Escherichia coli O104:H4 str. 2011C-3493 paraquat-inducible membrane protein A YP_006779992.1 3370579 R 1133852 CDS YP_006779993.1 407482844 13701374 complement(3371962..3373869) 1 NC_018658.1 COG0488 ATPase components of ABC transporters with duplicated ATPase domains; ABC transporter ATPase 3373869 13701374 O3K_16595 Escherichia coli O104:H4 str. 2011C-3493 ABC transporter ATPase YP_006779993.1 3371962 R 1133852 CDS YP_006779994.1 407482845 13701375 complement(3373880..3375988) 1 NC_018658.1 COG0116 Predicted N6-adenine-specific DNA methylase; 23S rRNA m(2)G2445 methyltransferase 3375988 rlmL 13701375 rlmL Escherichia coli O104:H4 str. 2011C-3493 23S rRNA m(2)G2445 methyltransferase YP_006779994.1 3373880 R 1133852 CDS YP_006779995.1 407482846 13701376 3376232..3377341 1 NC_018658.1 COG3217 Uncharacterized Fe-S protein; 2Fe-2S cluster-containing protein 3377341 13701376 O3K_16605 Escherichia coli O104:H4 str. 2011C-3493 2Fe-2S cluster-containing protein YP_006779995.1 3376232 D 1133852 CDS YP_006779996.1 407482847 13701377 complement(3377338..3377880) 1 NC_018658.1 hypothetical protein 3377880 13701377 O3K_16610 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006779996.1 3377338 R 1133852 CDS YP_006779997.1 407482848 13701378 complement(3378054..3379064) 1 NC_018658.1 COG0167 Dihydroorotate dehydrogenase; dihydroorotate dehydrogenase 2 3379064 13701378 O3K_16615 Escherichia coli O104:H4 str. 2011C-3493 dihydroorotate dehydrogenase 2 YP_006779997.1 3378054 R 1133852 CDS YP_006779998.1 407482849 13701379 complement(3379175..3379885) 1 NC_018658.1 COG3121 P pilus assembly protein, chaperone PapD; pili assembly chaperone 3379885 13701379 O3K_16620 Escherichia coli O104:H4 str. 2011C-3493 pili assembly chaperone YP_006779998.1 3379175 R 1133852 CDS YP_006779999.1 407482850 13701380 complement(3379878..3380393) 1 NC_018658.1 COG3539 P pilus assembly protein, pilin FimA; putative fimbrial protein 3380393 13701380 O3K_16625 Escherichia coli O104:H4 str. 2011C-3493 putative fimbrial protein YP_006779999.1 3379878 R 1133852 CDS YP_006780000.1 407482851 13701381 complement(3380401..3380943) 1 NC_018658.1 COG3539 P pilus assembly protein, pilin FimA; putative fimbrial-like adhesin protein 3380943 13701381 O3K_16630 Escherichia coli O104:H4 str. 2011C-3493 putative fimbrial-like adhesin protein YP_006780000.1 3380401 R 1133852 CDS YP_006780001.1 407482852 13701382 complement(3380955..3382025) 1 NC_018658.1 putative fimbrial-like adhesin protein 3382025 13701382 O3K_16635 Escherichia coli O104:H4 str. 2011C-3493 putative fimbrial-like adhesin protein YP_006780001.1 3380955 R 1133852 CDS YP_006780002.1 407482853 13701383 complement(3382016..3384616) 1 NC_018658.1 COG3188 P pilus assembly protein, porin PapC; outer membrane usher protein 3384616 13701383 O3K_16640 Escherichia coli O104:H4 str. 2011C-3493 outer membrane usher protein YP_006780002.1 3382016 R 1133852 CDS YP_006780003.1 407482854 13701384 complement(3384641..3385342) 1 NC_018658.1 COG3121 P pilus assembly protein, chaperone PapD; putative periplasmic pilin chaperone 3385342 13701384 O3K_16645 Escherichia coli O104:H4 str. 2011C-3493 putative periplasmic pilin chaperone YP_006780003.1 3384641 R 1133852 CDS YP_006780004.1 407482855 13701385 complement(3385425..3385967) 1 NC_018658.1 COG3539 P pilus assembly protein, pilin FimA; putative fimbrial-like adhesin protein 3385967 13701385 O3K_16650 Escherichia coli O104:H4 str. 2011C-3493 putative fimbrial-like adhesin protein YP_006780004.1 3385425 R 1133852 CDS YP_006780005.1 407482856 13701386 3386323..3386898 1 NC_018658.1 COG0431 Predicted flavoprotein; NAD(P)H-dependent FMN reductase 3386898 13701386 O3K_16655 Escherichia coli O104:H4 str. 2011C-3493 NAD(P)H-dependent FMN reductase YP_006780005.1 3386323 D 1133852 CDS YP_006780006.1 407482857 13701387 3386891..3387850 1 NC_018658.1 COG0715 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components; alkanesulfonate transporter substrate-binding subunit 3387850 13701387 O3K_16660 Escherichia coli O104:H4 str. 2011C-3493 alkanesulfonate transporter substrate-binding subunit YP_006780006.1 3386891 D 1133852 CDS YP_006780007.1 407482858 13701388 3387847..3388992 1 NC_018658.1 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases; alkanesulfonate monooxygenase 3388992 13701388 O3K_16665 Escherichia coli O104:H4 str. 2011C-3493 alkanesulfonate monooxygenase YP_006780007.1 3387847 D 1133852 CDS YP_006780008.1 407482859 13701389 3389003..3389794 1 NC_018658.1 COG0600 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component; alkanesulfonate transporter permease 3389794 ssuC 13701389 ssuC Escherichia coli O104:H4 str. 2011C-3493 alkanesulfonate transporter permease YP_006780008.1 3389003 D 1133852 CDS YP_006780009.1 407482860 13701390 3389791..3390558 1 NC_018658.1 COG1116 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component; aliphatic sulfonates transport ATP-binding subunit 3390558 ssuB 13701390 ssuB Escherichia coli O104:H4 str. 2011C-3493 aliphatic sulfonates transport ATP-binding subunit YP_006780009.1 3389791 D 1133852 CDS YP_006780010.1 407482861 13701391 complement(3390765..3393377) 1 NC_018658.1 COG0308 Aminopeptidase N; aminopeptidase N 3393377 pepN 13701391 pepN Escherichia coli O104:H4 str. 2011C-3493 aminopeptidase N YP_006780010.1 3390765 R 1133852 CDS YP_006780011.1 407482862 13701392 3393643..3394845 1 NC_018658.1 COG1488 Nicotinic acid phosphoribosyltransferase; nicotinate phosphoribosyltransferase 3394845 13701392 O3K_16685 Escherichia coli O104:H4 str. 2011C-3493 nicotinate phosphoribosyltransferase YP_006780011.1 3393643 D 1133852 CDS YP_006780012.1 407482863 13701393 3395014..3396414 1 NC_018658.1 COG0017 Aspartyl/asparaginyl-tRNA synthetases; asparaginyl-tRNA synthetase 3396414 asnC 13701393 asnC Escherichia coli O104:H4 str. 2011C-3493 asparaginyl-tRNA synthetase YP_006780012.1 3395014 D 1133852 CDS YP_006780013.1 407482864 13701394 3397016..3398104 1 NC_018658.1 COG3203 Outer membrane protein (porin); outer membrane protein F 3398104 13701394 O3K_16695 Escherichia coli O104:H4 str. 2011C-3493 outer membrane protein F YP_006780013.1 3397016 D 1133852 CDS YP_006780014.1 407482865 13701395 complement(3398120..3398290) 1 NC_018658.1 hypothetical protein 3398290 13701395 O3K_16700 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780014.1 3398120 R 1133852 CDS YP_006780015.1 407482866 13701396 3398289..3399479 1 NC_018658.1 COG1448 Aspartate/tyrosine/aromatic aminotransferase; aromatic amino acid aminotransferase 3399479 13701396 O3K_16705 Escherichia coli O104:H4 str. 2011C-3493 aromatic amino acid aminotransferase YP_006780015.1 3398289 D 1133852 CDS YP_006780016.1 407482867 13701397 3399758..3400738 1 NC_018658.1 COG3547 Transposase and inactivated derivatives; IS621 transposase 3400738 13701397 O3K_16710 Escherichia coli O104:H4 str. 2011C-3493 IS621 transposase YP_006780016.1 3399758 D 1133852 CDS YP_006780017.1 407482868 13701398 complement(3400980..3401627) 1 NC_018658.1 COG0491 Zn-dependent hydrolases, including glyoxylases; putative metal-binding enzyme 3401627 13701398 O3K_16715 Escherichia coli O104:H4 str. 2011C-3493 putative metal-binding enzyme YP_006780017.1 3400980 R 1133852 CDS YP_006780018.1 407482869 13701399 complement(3401654..3402202) 1 NC_018658.1 COG3108 Uncharacterized protein conserved in bacteria; hypothetical protein 3402202 13701399 O3K_16720 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780018.1 3401654 R 1133852 CDS YP_006780019.1 407482870 13701400 complement(3402383..3404230) 1 NC_018658.1 COG2989 Uncharacterized protein conserved in bacteria; murein L,D-transpeptidase 3404230 13701400 O3K_16725 Escherichia coli O104:H4 str. 2011C-3493 murein L,D-transpeptidase YP_006780019.1 3402383 R 1133852 CDS YP_006780020.1 407482871 13701401 complement(3404491..3408951) 1 NC_018658.1 COG3096 Uncharacterized protein involved in chromosome partitioning; cell division protein MukB 3408951 mukB 13701401 mukB Escherichia coli O104:H4 str. 2011C-3493 cell division protein MukB YP_006780020.1 3404491 R 1133852 CDS YP_006780021.1 407482872 13701402 complement(3408951..3409655) 1 NC_018658.1 COG3095 Uncharacterized protein involved in chromosome partitioning; condesin subunit E 3409655 13701402 O3K_16735 Escherichia coli O104:H4 str. 2011C-3493 condesin subunit E YP_006780021.1 3408951 R 1133852 CDS YP_006780022.1 407482873 13701403 complement(3409636..3410958) 1 NC_018658.1 COG3006 Uncharacterized protein involved in chromosome partitioning; condesin subunit F 3410958 13701403 O3K_16740 Escherichia coli O104:H4 str. 2011C-3493 condesin subunit F YP_006780022.1 3409636 R 1133852 CDS YP_006780023.1 407482874 13701404 complement(3410955..3411740) 1 NC_018658.1 COG0500 SAM-dependent methyltransferases; putative S-adenosyl-L-methionine-dependent methyltransferase 3411740 13701404 O3K_16745 Escherichia coli O104:H4 str. 2011C-3493 putative S-adenosyl-L-methionine-dependent methyltransferase YP_006780023.1 3410955 R 1133852 CDS YP_006780024.1 407482875 13701405 3411876..3412655 1 NC_018658.1 COG1434 Uncharacterized conserved protein; hypothetical protein 3412655 13701405 O3K_16750 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780024.1 3411876 D 1133852 CDS YP_006780025.1 407482876 13701406 complement(3412632..3413525) 1 NC_018658.1 hypothetical protein 3413525 13701406 O3K_16755 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780025.1 3412632 R 1133852 CDS YP_006780026.1 407482877 13701407 complement(3413679..3414425) 1 NC_018658.1 COG1212 CMP-2-keto-3-deoxyoctulosonic acid synthetase; 3-deoxy-manno-octulosonate cytidylyltransferase 3414425 13701407 O3K_16760 Escherichia coli O104:H4 str. 2011C-3493 3-deoxy-manno-octulosonate cytidylyltransferase YP_006780026.1 3413679 R 1133852 CDS YP_006780027.1 407482878 13701408 complement(3414422..3414604) 1 NC_018658.1 COG2835 Uncharacterized conserved protein; hypothetical protein 3414604 13701408 O3K_16765 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780027.1 3414422 R 1133852 CDS YP_006780028.1 407482879 13701409 complement(3414656..3415888) 1 NC_018658.1 COG3214 Uncharacterized protein conserved in bacteria; hypothetical protein 3415888 13701409 O3K_16770 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780028.1 3414656 R 1133852 CDS YP_006780029.1 407482880 13701410 complement(3415925..3416911) 1 NC_018658.1 COG1663 Tetraacyldisaccharide-1-P 4'-kinase; tetraacyldisaccharide 4'-kinase 3416911 lpxK 13701410 lpxK Escherichia coli O104:H4 str. 2011C-3493 tetraacyldisaccharide 4'-kinase YP_006780029.1 3415925 R 1133852 CDS YP_006780030.1 407482881 13701411 complement(3416908..3418656) 1 NC_018658.1 COG1132 ABC-type multidrug transport system, ATPase and permease components; lipid transporter ATP-binding/permease 3418656 13701411 O3K_16780 Escherichia coli O104:H4 str. 2011C-3493 lipid transporter ATP-binding/permease YP_006780030.1 3416908 R 1133852 CDS YP_006780031.1 407482882 13701412 complement(3418693..3420957) 1 NC_018658.1 COG0658 Predicted membrane metal-binding protein; ComEC family competence protein 3420957 13701412 O3K_16785 Escherichia coli O104:H4 str. 2011C-3493 ComEC family competence protein YP_006780031.1 3418693 R 1133852 CDS YP_006780032.1 407482883 13701413 complement(3421164..3421448) 1 NC_018658.1 COG0776 Bacterial nucleoid DNA-binding protein; integration host factor subunit beta 3421448 ihfB 13701413 ihfB Escherichia coli O104:H4 str. 2011C-3493 integration host factor subunit beta YP_006780032.1 3421164 R 1133852 CDS YP_006780033.1 407482884 13701414 complement(3421608..3423281) 1 NC_018658.1 COG0539 Ribosomal protein S1; 30S ribosomal protein S1 3423281 rpsA 13701414 rpsA Escherichia coli O104:H4 str. 2011C-3493 30S ribosomal protein S1 YP_006780033.1 3421608 R 1133852 CDS YP_006780034.1 407482885 13701415 complement(3423392..3424075) 1 NC_018658.1 COG0283 Cytidylate kinase; cytidylate kinase 3424075 cmk 13701415 cmk Escherichia coli O104:H4 str. 2011C-3493 cytidylate kinase YP_006780034.1 3423392 R 1133852 CDS YP_006780035.1 407482886 13701416 complement(3424248..3425012) 1 NC_018658.1 COG0501 Zn-dependent protease with chaperone function; heat shock protein 3425012 13701416 O3K_16805 Escherichia coli O104:H4 str. 2011C-3493 heat shock protein YP_006780035.1 3424248 R 1133852 CDS YP_006780036.1 407482887 13701417 complement(3425181..3426464) 1 NC_018658.1 COG0128 5-enolpyruvylshikimate-3-phosphate synthase; 3-phosphoshikimate 1-carboxyvinyltransferase 3426464 13701417 O3K_16810 Escherichia coli O104:H4 str. 2011C-3493 3-phosphoshikimate 1-carboxyvinyltransferase YP_006780036.1 3425181 R 1133852 CDS YP_006780037.1 407482888 13701418 complement(3426535..3427623) 1 NC_018658.1 COG1932 Phosphoserine aminotransferase; 3-phosphoserine/phosphohydroxythreonine aminotransferase 3427623 13701418 O3K_16815 Escherichia coli O104:H4 str. 2011C-3493 3-phosphoserine/phosphohydroxythreonine aminotransferase YP_006780037.1 3426535 R 1133852 CDS YP_006780038.1 407482889 13701419 complement(3427822..3428514) 1 NC_018658.1 COG2323 Predicted membrane protein; hypothetical protein 3428514 13701419 O3K_16820 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780038.1 3427822 R 1133852 CDS YP_006780039.1 407482890 13701420 3428644..3430404 1 NC_018658.1 COG1944 Uncharacterized conserved protein; hypothetical protein 3430404 13701420 O3K_16825 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780039.1 3428644 D 1133852 CDS YP_006780040.1 407482891 13701421 3430809..3431666 1 NC_018658.1 COG2116 Formate/nitrite family of transporters; formate transporter 3431666 13701421 O3K_16830 Escherichia coli O104:H4 str. 2011C-3493 formate transporter YP_006780040.1 3430809 D 1133852 CDS YP_006780041.1 407482892 13701422 3431721..3434003 1 NC_018658.1 COG1882 Pyruvate-formate lyase; formate acetyltransferase 3434003 13701422 O3K_16835 Escherichia coli O104:H4 str. 2011C-3493 formate acetyltransferase YP_006780041.1 3431721 D 1133852 CDS YP_006780042.1 407482893 13701423 3434195..3434935 1 NC_018658.1 COG1180 Pyruvate-formate lyase-activating enzyme; pyruvate formate lyase-activating enzyme 1 3434935 pflA 13701423 pflA Escherichia coli O104:H4 str. 2011C-3493 pyruvate formate lyase-activating enzyme 1 YP_006780042.1 3434195 D 1133852 CDS YP_006780043.1 407482894 13701424 complement(3435017..3435607) 1 NC_018658.1 COG2249 Putative NADPH-quinone reductase (modulator of drug activity B); hypothetical protein 3435607 13701424 O3K_16845 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780043.1 3435017 R 1133852 CDS YP_006780044.1 407482895 13701425 3435707..3436615 1 NC_018658.1 COG0583 Transcriptional regulator; putative DNA-binding transcriptional regulator 3436615 13701425 O3K_16850 Escherichia coli O104:H4 str. 2011C-3493 putative DNA-binding transcriptional regulator YP_006780044.1 3435707 D 1133852 CDS YP_006780045.1 407482896 13701426 complement(3436616..3438046) 1 NC_018658.1 COG0531 Amino acid transporters; transporter 3438046 13701426 O3K_16855 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006780045.1 3436616 R 1133852 CDS YP_006780046.1 407482897 13701427 complement(3438256..3439404) 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; putative MFS family transporter protein 3439404 13701427 O3K_16860 Escherichia coli O104:H4 str. 2011C-3493 putative MFS family transporter protein YP_006780046.1 3438256 R 1133852 CDS YP_006780047.1 407482898 13701428 3439718..3440344 1 NC_018658.1 COG1335 Amidases related to nicotinamidase; hydrolase 3440344 13701428 O3K_16865 Escherichia coli O104:H4 str. 2011C-3493 hydrolase YP_006780047.1 3439718 D 1133852 CDS YP_006780048.1 407482899 13701429 complement(3440380..3441243) 1 NC_018658.1 COG3302 DMSO reductase anchor subunit; dimethyl sulfoxide reductase, anaerobic subunit C 3441243 13701429 O3K_16870 Escherichia coli O104:H4 str. 2011C-3493 dimethyl sulfoxide reductase, anaerobic subunit C YP_006780048.1 3440380 R 1133852 CDS YP_006780049.1 407482900 13701430 complement(3441245..3441862) 1 NC_018658.1 COG0437 Fe-S-cluster-containing hydrogenase components 1; anaerobic dimethyl sulfoxide reductase subunit B 3441862 13701430 O3K_16875 Escherichia coli O104:H4 str. 2011C-3493 anaerobic dimethyl sulfoxide reductase subunit B YP_006780049.1 3441245 R 1133852 CDS YP_006780050.1 407482901 13701431 complement(3441873..3444317) 1 NC_018658.1 COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; anaerobic dimethyl sulfoxide reductase subunit A 3444317 13701431 O3K_16880 Escherichia coli O104:H4 str. 2011C-3493 anaerobic dimethyl sulfoxide reductase subunit A YP_006780050.1 3441873 R 1133852 CDS YP_006780051.1 407482902 13701432 complement(3444556..3445848) 1 NC_018658.1 COG0172 Seryl-tRNA synthetase; seryl-tRNA synthetase 3445848 13701432 O3K_16885 Escherichia coli O104:H4 str. 2011C-3493 seryl-tRNA synthetase YP_006780051.1 3444556 R 1133852 CDS YP_006780052.1 407482903 13701433 complement(3445939..3447282) 1 NC_018658.1 COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase; recombination factor protein RarA 3447282 13701433 O3K_16890 Escherichia coli O104:H4 str. 2011C-3493 recombination factor protein RarA YP_006780052.1 3445939 R 1133852 CDS YP_006780053.1 407482904 13701434 complement(3447293..3447904) 1 NC_018658.1 COG2834 Outer membrane lipoprotein-sorting protein; lipoprotein chaperone 3447904 lolA 13701434 lolA Escherichia coli O104:H4 str. 2011C-3493 lipoprotein chaperone YP_006780053.1 3447293 R 1133852 CDS YP_006780054.1 407482905 13701435 complement(3448059..3452126) 1 NC_018658.1 COG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins; DNA translocase FtsK 3452126 13701435 O3K_16900 Escherichia coli O104:H4 str. 2011C-3493 DNA translocase FtsK YP_006780054.1 3448059 R 1133852 CDS YP_006780055.1 407482906 13701436 complement(3452261..3452755) 1 NC_018658.1 COG1522 Transcriptional regulators; leucine-responsive transcriptional regulator 3452755 13701436 O3K_16905 Escherichia coli O104:H4 str. 2011C-3493 leucine-responsive transcriptional regulator YP_006780055.1 3452261 R 1133852 CDS YP_006780056.1 407482907 13701437 3453300..3454265 1 NC_018658.1 COG0492 Thioredoxin reductase; thioredoxin reductase 3454265 13701437 O3K_16910 Escherichia coli O104:H4 str. 2011C-3493 thioredoxin reductase YP_006780056.1 3453300 D 1133852 CDS YP_006780057.1 407482908 13701438 3454388..3456154 1 NC_018658.1 COG4988 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components; cysteine/glutathione ABC transporter membrane/ATP-binding protein 3456154 13701438 O3K_16915 Escherichia coli O104:H4 str. 2011C-3493 cysteine/glutathione ABC transporter membrane/ATP-binding protein YP_006780057.1 3454388 D 1133852 CDS YP_006780058.1 407482909 13701439 3456155..3457876 1 NC_018658.1 COG4987 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components; cysteine/glutathione ABC transporter membrane/ATP-binding protein 3457876 13701439 O3K_16920 Escherichia coli O104:H4 str. 2011C-3493 cysteine/glutathione ABC transporter membrane/ATP-binding protein YP_006780058.1 3456155 D 1133852 CDS YP_006780059.1 407482910 13701440 3457918..3458622 1 NC_018658.1 COG2360 Leu/Phe-tRNA-protein transferase; leucyl/phenylalanyl-tRNA--protein transferase 3458622 aat 13701440 aat Escherichia coli O104:H4 str. 2011C-3493 leucyl/phenylalanyl-tRNA--protein transferase YP_006780059.1 3457918 D 1133852 CDS YP_006780060.1 407482911 13701441 3458907..3459125 1 NC_018658.1 COG0361 Translation initiation factor 1 (IF-1); translation initiation factor IF-1 3459125 infA 13701441 infA Escherichia coli O104:H4 str. 2011C-3493 translation initiation factor IF-1 YP_006780060.1 3458907 D 1133852 CDS YP_006780061.1 407482912 13701443 complement(3459810..3462086) 1 NC_018658.1 COG0542 ATPases with chaperone activity, ATP-binding subunit; ATP-dependent Clp protease ATP-binding subunit 3462086 clpA 13701443 clpA Escherichia coli O104:H4 str. 2011C-3493 ATP-dependent Clp protease ATP-binding subunit YP_006780061.1 3459810 R 1133852 CDS YP_006780062.1 407482913 13701444 complement(3462117..3462437) 1 NC_018658.1 COG2127 Uncharacterized conserved protein; ATP-dependent Clp protease adaptor protein ClpS 3462437 clpS 13701444 clpS Escherichia coli O104:H4 str. 2011C-3493 ATP-dependent Clp protease adaptor protein ClpS YP_006780062.1 3462117 R 1133852 CDS YP_006780063.1 407482914 13701445 3462760..3462984 1 NC_018658.1 COG1278 Cold shock proteins; stationary phase/starvation inducible regulatory protein CspD 3462984 13701445 O3K_16945 Escherichia coli O104:H4 str. 2011C-3493 stationary phase/starvation inducible regulatory protein CspD YP_006780063.1 3462760 D 1133852 CDS YP_006780064.1 407482915 13701446 complement(3463057..3465003) 1 NC_018658.1 COG1136 ABC-type antimicrobial peptide transport system, ATPase component; macrolide transporter ATP-binding /permease 3465003 13701446 O3K_16950 Escherichia coli O104:H4 str. 2011C-3493 macrolide transporter ATP-binding /permease YP_006780064.1 3463057 R 1133852 CDS YP_006780065.1 407482916 13701447 complement(3465000..3466115) 1 NC_018658.1 COG0845 Membrane-fusion protein; macrolide transporter subunit MacA 3466115 13701447 O3K_16955 Escherichia coli O104:H4 str. 2011C-3493 macrolide transporter subunit MacA YP_006780065.1 3465000 R 1133852 CDS YP_006780066.1 407482917 13701448 3466230..3467222 1 NC_018658.1 COG2990 Uncharacterized protein conserved in bacteria; hypothetical protein 3467222 13701448 O3K_16960 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780066.1 3466230 D 1133852 CDS YP_006780067.1 407482918 13701449 complement(3467219..3468877) 1 NC_018658.1 COG3593 Predicted ATP-dependent endonuclease of the OLD family; putative OLD family ATP-dependent endonuclease 3468877 13701449 O3K_16965 Escherichia coli O104:H4 str. 2011C-3493 putative OLD family ATP-dependent endonuclease YP_006780067.1 3467219 R 1133852 CDS YP_006780068.1 407482919 13701450 3469303..3469998 1 NC_018658.1 COG0580 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family); aquaporin Z 3469998 13701450 O3K_16970 Escherichia coli O104:H4 str. 2011C-3493 aquaporin Z YP_006780068.1 3469303 D 1133852 CDS YP_006780069.1 407482920 13701451 3470493..3471392 1 NC_018658.1 COG2431 Predicted membrane protein; transporter 3471392 13701451 O3K_16975 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006780069.1 3470493 D 1133852 CDS YP_006780070.1 407482921 13701452 3471536..3473188 1 NC_018658.1 COG1151 6Fe-6S prismane cluster-containing protein; hybrid cluster protein 3473188 13701452 O3K_16980 Escherichia coli O104:H4 str. 2011C-3493 hybrid cluster protein YP_006780070.1 3471536 D 1133852 CDS YP_006780071.1 407482922 13701453 3473200..3474168 1 NC_018658.1 COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1; HCP oxidoreductase 3474168 13701453 O3K_16985 Escherichia coli O104:H4 str. 2011C-3493 HCP oxidoreductase YP_006780071.1 3473200 D 1133852 CDS YP_006780072.1 407482923 13701454 3474301..3476019 1 NC_018658.1 COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; pyruvate dehydrogenase 3476019 13701454 O3K_16990 Escherichia coli O104:H4 str. 2011C-3493 pyruvate dehydrogenase YP_006780072.1 3474301 D 1133852 CDS YP_006780073.1 407482924 13701455 3476056..3477057 1 NC_018658.1 COG2008 Threonine aldolase; L-threonine aldolase 3477057 13701455 O3K_16995 Escherichia coli O104:H4 str. 2011C-3493 L-threonine aldolase YP_006780073.1 3476056 D 1133852 CDS YP_006780074.1 407482925 13701456 3477068..3478498 1 NC_018658.1 COG0702 Predicted nucleoside-diphosphate-sugar epimerases; hypothetical protein 3478498 13701456 O3K_17000 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780074.1 3477068 D 1133852 CDS YP_006780075.1 407482926 13701457 3478597..3479610 1 NC_018658.1 COG0451 Nucleoside-diphosphate-sugar epimerases; NAD dependent epimerase/dehydratase family protein 3479610 13701457 O3K_17005 Escherichia coli O104:H4 str. 2011C-3493 NAD dependent epimerase/dehydratase family protein YP_006780075.1 3478597 D 1133852 CDS YP_006780076.1 407482927 13701458 complement(3479607..3480437) 1 NC_018658.1 COG3023 Negative regulator of beta-lactamase expression; N-acetylmuramoyl-L-alanine amidase AmiD 3480437 13701458 O3K_17010 Escherichia coli O104:H4 str. 2011C-3493 N-acetylmuramoyl-L-alanine amidase AmiD YP_006780076.1 3479607 R 1133852 CDS YP_006780077.1 407482928 13701459 complement(3480434..3480757) 1 NC_018658.1 COG0393 Uncharacterized conserved protein; hypothetical protein 3480757 13701459 O3K_17015 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780077.1 3480434 R 1133852 CDS YP_006780078.1 407482929 13701460 3480883..3481398 1 NC_018658.1 COG0174 Glutamine synthetase; lipoprotein 3481398 13701460 O3K_17020 Escherichia coli O104:H4 str. 2011C-3493 lipoprotein YP_006780078.1 3480883 D 1133852 CDS YP_006780079.1 407482930 13701461 3481616..3482344 1 NC_018658.1 COG4161 ABC-type arginine transport system, ATPase component; arginine transporter ATP-binding subunit 3482344 artP 13701461 artP Escherichia coli O104:H4 str. 2011C-3493 arginine transporter ATP-binding subunit YP_006780079.1 3481616 D 1133852 CDS YP_006780080.1 407482931 13701462 3482362..3483093 1 NC_018658.1 COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; arginine ABC transporter substrate-binding protein 3483093 13701462 O3K_17030 Escherichia coli O104:H4 str. 2011C-3493 arginine ABC transporter substrate-binding protein YP_006780080.1 3482362 D 1133852 CDS YP_006780081.1 407482932 13701463 3483100..3483816 1 NC_018658.1 COG4215 ABC-type arginine transport system, permease component; arginine transporter permease subunit ArtQ 3483816 13701463 O3K_17035 Escherichia coli O104:H4 str. 2011C-3493 arginine transporter permease subunit ArtQ YP_006780081.1 3483100 D 1133852 CDS YP_006780082.1 407482933 13701464 3483816..3484484 1 NC_018658.1 COG4160 ABC-type arginine/histidine transport system, permease component; arginine transporter permease subunit ArtM 3484484 artM 13701464 artM Escherichia coli O104:H4 str. 2011C-3493 arginine transporter permease subunit ArtM YP_006780082.1 3483816 D 1133852 CDS YP_006780083.1 407482934 13701465 3484776..3485507 1 NC_018658.1 COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; arginine 3rd transport system periplasmic binding protein ArtJ 3485507 13701465 O3K_17045 Escherichia coli O104:H4 str. 2011C-3493 arginine 3rd transport system periplasmic binding protein ArtJ YP_006780083.1 3484776 D 1133852 CDS YP_006780084.1 407482935 13701466 complement(3485682..3486809) 1 NC_018658.1 COG2265 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase; 23S rRNA methyluridine methyltransferase 3486809 rumB 13701466 rumB Escherichia coli O104:H4 str. 2011C-3493 23S rRNA methyluridine methyltransferase YP_006780084.1 3485682 R 1133852 CDS YP_006780085.1 407482936 13701467 complement(3486850..3487338) 1 NC_018658.1 inner membrane protein 3487338 13701467 O3K_17055 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006780085.1 3486850 R 1133852 CDS YP_006780086.1 407482937 13701468 complement(3487398..3488243) 1 NC_018658.1 COG1177 ABC-type spermidine/putrescine transport system, permease component II; putrescine ABC transporter permease 3488243 13701468 O3K_17060 Escherichia coli O104:H4 str. 2011C-3493 putrescine ABC transporter permease YP_006780086.1 3487398 R 1133852 CDS YP_006780087.1 407482938 13701469 complement(3488240..3489193) 1 NC_018658.1 COG1176 ABC-type spermidine/putrescine transport system, permease component I; putrescine ABC transporter permease 3489193 13701469 O3K_17065 Escherichia coli O104:H4 str. 2011C-3493 putrescine ABC transporter permease YP_006780087.1 3488240 R 1133852 CDS YP_006780088.1 407482939 13701470 complement(3489203..3490336) 1 NC_018658.1 COG3842 ABC-type spermidine/putrescine transport systems, ATPase components; putrescine ABC transporter ATP-binding protein 3490336 potG 13701470 potG Escherichia coli O104:H4 str. 2011C-3493 putrescine ABC transporter ATP-binding protein YP_006780088.1 3489203 R 1133852 CDS YP_006780089.1 407482940 13701471 complement(3490431..3491543) 1 NC_018658.1 COG0687 Spermidine/putrescine-binding periplasmic protein; putrescine ABC transporter substrate-binding protein 3491543 13701471 O3K_17075 Escherichia coli O104:H4 str. 2011C-3493 putrescine ABC transporter substrate-binding protein YP_006780089.1 3490431 R 1133852 CDS YP_006780090.1 407482941 13701472 complement(3491895..3492371) 1 NC_018658.1 sensory transduction regulator 3492371 13701472 O3K_17080 Escherichia coli O104:H4 str. 2011C-3493 sensory transduction regulator YP_006780090.1 3491895 R 1133852 CDS YP_006780091.1 407482942 13701473 complement(3492459..3493361) 1 NC_018658.1 COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase); ribosomal protein S6 modification protein 3493361 13701473 O3K_17085 Escherichia coli O104:H4 str. 2011C-3493 ribosomal protein S6 modification protein YP_006780091.1 3492459 R 1133852 CDS YP_006780092.1 407482943 13701474 complement(3493422..3494144) 1 NC_018658.1 COG0778 Nitroreductase; nitroreductase A 3494144 13701474 O3K_17090 Escherichia coli O104:H4 str. 2011C-3493 nitroreductase A YP_006780092.1 3493422 R 1133852 CDS YP_006780093.1 407482944 13701475 complement(3494128..3494415) 1 NC_018658.1 hypothetical protein 3494415 13701475 O3K_17095 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780093.1 3494128 R 1133852 CDS YP_006780094.1 407482945 13701476 3494575..3494832 1 NC_018658.1 COG0695 Glutaredoxin and related proteins; glutaredoxin 3494832 grxA 13701476 grxA Escherichia coli O104:H4 str. 2011C-3493 glutaredoxin YP_006780094.1 3494575 D 1133852 CDS YP_006780095.1 407482946 13701477 complement(3494862..3495239) 1 NC_018658.1 hypothetical protein 3495239 13701477 O3K_17105 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780095.1 3494862 R 1133852 CDS YP_006780096.1 407482947 13701478 3495509..3497194 1 NC_018658.1 COG2985 Predicted permease; transporter 3497194 13701478 O3K_17110 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006780096.1 3495509 D 1133852 CDS YP_006780097.1 407482948 13701479 complement(3497369..3497905) 1 NC_018658.1 COG3226 Uncharacterized protein conserved in bacteria; DNA-binding transcriptional regulator 3497905 13701479 O3K_17115 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator YP_006780097.1 3497369 R 1133852 CDS YP_006780098.1 407482949 13701480 3497989..3499197 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; transporter 3499197 13701480 O3K_17120 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006780098.1 3497989 D 1133852 CDS YP_006780099.1 407482950 13701481 3499197..3500012 1 NC_018658.1 COG0561 Predicted hydrolases of the HAD superfamily; phosphatase 3500012 13701481 O3K_17125 Escherichia coli O104:H4 str. 2011C-3493 phosphatase YP_006780099.1 3499197 D 1133852 CDS YP_006780100.1 407482951 13701482 3500098..3500382 1 NC_018658.1 hypothetical protein 3500382 13701482 O3K_17130 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780100.1 3500098 D 1133852 CDS YP_006780101.1 407482952 13701483 complement(3500423..3501655) 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; multidrug efflux system translocase MdfA 3501655 13701483 O3K_17135 Escherichia coli O104:H4 str. 2011C-3493 multidrug efflux system translocase MdfA YP_006780101.1 3500423 R 1133852 CDS YP_006780102.1 407482953 13701565 3501940..3502536 1 NC_018658.1 COG0671 Membrane-associated phospholipid phosphatase; undecaprenyl pyrophosphate phosphatase 3502536 13701565 O3K_17140 Escherichia coli O104:H4 str. 2011C-3493 undecaprenyl pyrophosphate phosphatase YP_006780102.1 3501940 D 1133852 CDS YP_006780103.1 407482954 13701566 3502594..3503352 1 NC_018658.1 COG1349 Transcriptional regulators of sugar metabolism; DNA-binding transcriptional repressor DeoR 3503352 13701566 O3K_17145 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional repressor DeoR YP_006780103.1 3502594 D 1133852 CDS YP_006780104.1 407482955 13701567 complement(3503399..3504601) 1 NC_018658.1 COG1686 D-alanyl-D-alanine carboxypeptidase; D-alanyl-D-alanine carboxypeptidase 3504601 13701567 O3K_17150 Escherichia coli O104:H4 str. 2011C-3493 D-alanyl-D-alanine carboxypeptidase YP_006780104.1 3503399 R 1133852 CDS YP_006780105.1 407482956 13701568 3504848..3505474 1 NC_018658.1 COG0625 Glutathione S-transferase; transferase 3505474 13701568 O3K_17155 Escherichia coli O104:H4 str. 2011C-3493 transferase YP_006780105.1 3504848 D 1133852 CDS YP_006780106.1 407482957 13701569 complement(3505471..3506586) 1 NC_018658.1 COG2133 Glucose/sorbosone dehydrogenases; dehydrogenase 3506586 13701569 O3K_17160 Escherichia coli O104:H4 str. 2011C-3493 dehydrogenase YP_006780106.1 3505471 R 1133852 CDS YP_006780107.1 407482958 13701570 complement(3506697..3507080) 1 NC_018658.1 biofilm formation regulatory protein BssR 3507080 bssR 13701570 bssR Escherichia coli O104:H4 str. 2011C-3493 biofilm formation regulatory protein BssR YP_006780107.1 3506697 R 1133852 CDS YP_006780108.1 407482959 13701571 3507293..3508618 1 NC_018658.1 COG0621 2-methylthioadenine synthetase; 30S ribosomal protein S12 methylthiotransferase 3508618 rimO 13701571 rimO Escherichia coli O104:H4 str. 2011C-3493 30S ribosomal protein S12 methylthiotransferase YP_006780108.1 3507293 D 1133852 CDS YP_006780109.1 407482960 13701572 complement(3508665..3509993) 1 NC_018658.1 COG2199 FOG: GGDEF domain; putative diguanylate cyclase 3509993 13701572 O3K_17175 Escherichia coli O104:H4 str. 2011C-3493 putative diguanylate cyclase YP_006780109.1 3508665 R 1133852 CDS YP_006780110.1 407482961 13701573 complement(3510001..3512349) 1 NC_018658.1 COG2200 FOG: EAL domain; hypothetical protein 3512349 13701573 O3K_17180 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780110.1 3510001 R 1133852 CDS YP_006780111.1 407482962 13701574 complement(3512527..3513438) 1 NC_018658.1 COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; glutathione ABC transporter permease GsiD 3513438 13701574 O3K_17185 Escherichia coli O104:H4 str. 2011C-3493 glutathione ABC transporter permease GsiD YP_006780111.1 3512527 R 1133852 CDS YP_006780112.1 407482963 13701575 complement(3513441..3514361) 1 NC_018658.1 COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; glutathione ABC transporter permease GsiC 3514361 13701575 O3K_17190 Escherichia coli O104:H4 str. 2011C-3493 glutathione ABC transporter permease GsiC YP_006780112.1 3513441 R 1133852 CDS YP_006780113.1 407482964 13701576 complement(3514379..3515917) 1 NC_018658.1 COG0747 ABC-type dipeptide transport system, periplasmic component; glutathione ABC transporter substrate-binding protein GsiB 3515917 13701576 O3K_17195 Escherichia coli O104:H4 str. 2011C-3493 glutathione ABC transporter substrate-binding protein GsiB YP_006780113.1 3514379 R 1133852 CDS YP_006780114.1 407482965 13701577 complement(3515937..3517808) 1 NC_018658.1 COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase; glutathione transporter ATP-binding protein 3517808 13701577 O3K_17200 Escherichia coli O104:H4 str. 2011C-3493 glutathione transporter ATP-binding protein YP_006780114.1 3515937 R 1133852 CDS YP_006780115.1 407482966 13701578 complement(3517795..3518760) 1 NC_018658.1 COG1446 Asparaginase; isoaspartyl peptidase 3518760 13701578 O3K_17205 Escherichia coli O104:H4 str. 2011C-3493 isoaspartyl peptidase YP_006780115.1 3517795 R 1133852 CDS YP_006780116.1 407482967 13701579 3518964..3520199 1 NC_018658.1 COG0303 Molybdopterin biosynthesis enzyme; molybdopterin biosynthesis protein MoeA 3520199 13701579 O3K_17210 Escherichia coli O104:H4 str. 2011C-3493 molybdopterin biosynthesis protein MoeA YP_006780116.1 3518964 D 1133852 CDS YP_006780117.1 407482968 13701580 3520199..3520948 1 NC_018658.1 COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2; molybdopterin biosynthesis protein MoeB 3520948 13701580 O3K_17215 Escherichia coli O104:H4 str. 2011C-3493 molybdopterin biosynthesis protein MoeB YP_006780117.1 3520199 D 1133852 CDS YP_006780118.1 407482969 13701581 complement(3521036..3521698) 1 NC_018658.1 COG0176 Transaldolase; fructose-6-phosphate aldolase 3521698 13701581 O3K_17220 Escherichia coli O104:H4 str. 2011C-3493 fructose-6-phosphate aldolase YP_006780118.1 3521036 R 1133852 CDS YP_006780119.1 407482970 13701582 3521829..3522728 1 NC_018658.1 COG1180 Pyruvate-formate lyase-activating enzyme; putative pyruvate formate-lyase 3 activating protein 3522728 13701582 O3K_17225 Escherichia coli O104:H4 str. 2011C-3493 putative pyruvate formate-lyase 3 activating protein YP_006780119.1 3521829 D 1133852 CDS YP_006780120.1 407482971 13701583 3522734..3525166 1 NC_018658.1 COG1882 Pyruvate-formate lyase; putative pyruvate formate lyase 3525166 13701583 O3K_17230 Escherichia coli O104:H4 str. 2011C-3493 putative pyruvate formate lyase YP_006780120.1 3522734 D 1133852 CDS YP_006780121.1 407482972 13701584 3525312..3526127 1 NC_018658.1 COG0561 Predicted hydrolases of the HAD superfamily; hydrolase 3526127 13701584 O3K_17235 Escherichia coli O104:H4 str. 2011C-3493 hydrolase YP_006780121.1 3525312 D 1133852 CDS YP_006780122.1 407482973 13701585 3526279..3527544 1 NC_018658.1 hypothetical protein 3527544 13701585 O3K_17240 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780122.1 3526279 D 1133852 CDS YP_006780123.1 407482974 13701586 complement(3527800..3528780) 1 NC_018658.1 COG3547 Transposase and inactivated derivatives; IS621 transposase 3528780 13701586 O3K_17245 Escherichia coli O104:H4 str. 2011C-3493 IS621 transposase YP_006780123.1 3527800 R 1133852 CDS YP_006780124.1 407482975 13701587 complement(3529059..3530651) 1 NC_018658.1 COG0488 ATPase components of ABC transporters with duplicated ATPase domains; ABC transporter ATP-binding protein 3530651 13701587 O3K_17250 Escherichia coli O104:H4 str. 2011C-3493 ABC transporter ATP-binding protein YP_006780124.1 3529059 R 1133852 CDS YP_006780125.1 407482976 13701588 3530870..3531790 1 NC_018658.1 COG1376 Uncharacterized protein conserved in bacteria; L,D-transpeptidase 3531790 13701588 O3K_17255 Escherichia coli O104:H4 str. 2011C-3493 L,D-transpeptidase YP_006780125.1 3530870 D 1133852 CDS YP_006780126.1 407482977 13701589 complement(3531849..3532967) 1 NC_018658.1 COG0471 Di- and tricarboxylate transporters; transporter 3532967 13701589 O3K_17260 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006780126.1 3531849 R 1133852 CDS YP_006780127.1 407482978 13701590 complement(3532964..3533431) 1 NC_018658.1 COG1321 Mn-dependent transcriptional regulator; manganese transport regulator MntR 3533431 13701590 O3K_17265 Escherichia coli O104:H4 str. 2011C-3493 manganese transport regulator MntR YP_006780127.1 3532964 R 1133852 CDS YP_006780128.1 407482979 13701591 3533617..3533745 1 NC_018658.1 hypothetical protein 3533745 13701591 O3K_17270 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780128.1 3533617 D 1133852 CDS YP_006780129.1 407482980 13701592 3534017..3535600 1 NC_018658.1 COG2194 Predicted membrane-associated, metal-dependent hydrolase; hydrolase, inner membrane 3535600 13701592 O3K_17275 Escherichia coli O104:H4 str. 2011C-3493 hydrolase, inner membrane YP_006780129.1 3534017 D 1133852 CDS YP_006780130.1 407482981 13701593 complement(3535649..3536164) 1 NC_018658.1 COG3637 Opacity protein and related surface antigens; outer membrane protein X 3536164 ompX 13701593 ompX Escherichia coli O104:H4 str. 2011C-3493 outer membrane protein X YP_006780130.1 3535649 R 1133852 CDS YP_006780131.1 407482982 13701594 3536517..3537404 1 NC_018658.1 COG5006 Predicted permease, DMT superfamily; threonine and homoserine efflux system 3537404 13701594 O3K_17285 Escherichia coli O104:H4 str. 2011C-3493 threonine and homoserine efflux system YP_006780131.1 3536517 D 1133852 CDS YP_006780132.1 407482983 13701595 3537703..3538206 1 NC_018658.1 COG0783 DNA-binding ferritin-like protein (oxidative damage protectant); DNA starvation/stationary phase protection protein Dps 3538206 13701595 O3K_17290 Escherichia coli O104:H4 str. 2011C-3493 DNA starvation/stationary phase protection protein Dps YP_006780132.1 3537703 D 1133852 CDS YP_006780133.1 407482984 13701596 3538610..3539356 1 NC_018658.1 COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; glutamine ABC transporter substrate-binding protein 3539356 glnH 13701596 glnH Escherichia coli O104:H4 str. 2011C-3493 glutamine ABC transporter substrate-binding protein YP_006780133.1 3538610 D 1133852 CDS YP_006780134.1 407482985 13701597 3539495..3540154 1 NC_018658.1 COG0765 ABC-type amino acid transport system, permease component; glutamine ABC transporter permease 3540154 glnP 13701597 glnP Escherichia coli O104:H4 str. 2011C-3493 glutamine ABC transporter permease YP_006780134.1 3539495 D 1133852 CDS YP_006780135.1 407482986 13701598 3540151..3540873 1 NC_018658.1 COG1126 ABC-type polar amino acid transport system, ATPase component; glutamine ABC transporter ATP-binding protein 3540873 glnQ 13701598 glnQ Escherichia coli O104:H4 str. 2011C-3493 glutamine ABC transporter ATP-binding protein YP_006780135.1 3540151 D 1133852 CDS YP_006780136.1 407482987 13701599 3540990..3543215 1 NC_018658.1 COG0668 Small-conductance mechanosensitive channel; putative mechanosensitive channel protein 3543215 13701599 O3K_17310 Escherichia coli O104:H4 str. 2011C-3493 putative mechanosensitive channel protein YP_006780136.1 3540990 D 1133852 CDS YP_006780137.1 407482988 13701600 complement(3543212..3544138) 1 NC_018658.1 COG3129 Predicted SAM-dependent methyltransferase; 23S rRNA mA1618 methyltransferase 3544138 13701600 O3K_17315 Escherichia coli O104:H4 str. 2011C-3493 23S rRNA mA1618 methyltransferase YP_006780137.1 3543212 R 1133852 CDS YP_006780138.1 407482989 13701601 3544270..3544674 1 NC_018658.1 hypothetical protein 3544674 13701601 O3K_17320 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780138.1 3544270 D 1133852 CDS YP_006780139.1 407482990 13701602 3544939..3547221 1 NC_018658.1 COG4774 Outer membrane receptor for monomeric catechols; catecholate siderophore receptor Fiu 3547221 13701602 O3K_17325 Escherichia coli O104:H4 str. 2011C-3493 catecholate siderophore receptor Fiu YP_006780139.1 3544939 D 1133852 CDS YP_006780140.1 407482991 13701603 3547263..3547940 1 NC_018658.1 COG3128 Uncharacterized iron-regulated protein; Fe(II)-dependent oxygenase superfamily protein 3547940 13701603 O3K_17330 Escherichia coli O104:H4 str. 2011C-3493 Fe(II)-dependent oxygenase superfamily protein YP_006780140.1 3547263 D 1133852 CDS YP_006780141.1 407482992 13701604 3548014..3548280 1 NC_018658.1 COG1734 DnaK suppressor protein; hypothetical protein 3548280 13701604 O3K_17335 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780141.1 3548014 D 1133852 CDS YP_006780142.1 407482993 13701605 3548545..3548805 1 NC_018658.1 hypothetical protein 3548805 13701605 O3K_17340 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780142.1 3548545 D 1133852 CDS YP_006780143.1 407482994 13701606 complement(3549034..3550119) 1 NC_018658.1 COG2055 Malate/L-lactate dehydrogenases; putative dehydrogenase 3550119 13701606 O3K_17345 Escherichia coli O104:H4 str. 2011C-3493 putative dehydrogenase YP_006780143.1 3549034 R 1133852 CDS YP_006780144.1 407482995 13701607 complement(3550260..3551222) 1 NC_018658.1 COG0547 Anthranilate phosphoribosyltransferase; glycosyl transferase 3551222 13701607 O3K_17350 Escherichia coli O104:H4 str. 2011C-3493 glycosyl transferase YP_006780144.1 3550260 R 1133852 CDS YP_006780145.1 407482996 13701608 complement(3551250..3553400) 1 NC_018658.1 COG1199 Rad3-related DNA helicases; ATP-dependent DNA helicase DinG 3553400 dinG 13701608 dinG Escherichia coli O104:H4 str. 2011C-3493 ATP-dependent DNA helicase DinG YP_006780145.1 3551250 R 1133852 CDS YP_006780146.1 407482997 13701609 3553520..3554002 1 NC_018658.1 COG3236 Uncharacterized protein conserved in bacteria; hypothetical protein 3554002 13701609 O3K_17360 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780146.1 3553520 D 1133852 CDS YP_006780147.1 407482998 13701610 complement(3554234..3555598) 1 NC_018658.1 COG0513 Superfamily II DNA and RNA helicases; ATP-dependent RNA helicase RhlE 3555598 13701610 O3K_17365 Escherichia coli O104:H4 str. 2011C-3493 ATP-dependent RNA helicase RhlE YP_006780147.1 3554234 R 1133852 CDS YP_006780148.1 407482999 13701611 3555827..3556498 1 NC_018658.1 COG1309 Transcriptional regulator; putative DNA-binding transcriptional regulator 3556498 13701611 O3K_17370 Escherichia coli O104:H4 str. 2011C-3493 putative DNA-binding transcriptional regulator YP_006780148.1 3555827 D 1133852 CDS YP_006780149.1 407483000 13701612 3556501..3557496 1 NC_018658.1 COG0845 Membrane-fusion protein; putative efflux pump membrane fusion protein 3557496 13701612 O3K_17375 Escherichia coli O104:H4 str. 2011C-3493 putative efflux pump membrane fusion protein YP_006780149.1 3556501 D 1133852 CDS YP_006780150.1 407483001 13701613 3557489..3559225 1 NC_018658.1 COG1131 ABC-type multidrug transport system, ATPase component; ABC transporter ATP-binding protein 3559225 13701613 O3K_17380 Escherichia coli O104:H4 str. 2011C-3493 ABC transporter ATP-binding protein YP_006780150.1 3557489 D 1133852 CDS YP_006780151.1 407483002 13701614 3559218..3560351 1 NC_018658.1 COG0842 ABC-type multidrug transport system, permease component; ABC transporter permease 3560351 13701614 O3K_17385 Escherichia coli O104:H4 str. 2011C-3493 ABC transporter permease YP_006780151.1 3559218 D 1133852 CDS YP_006780152.1 407483003 13701615 3560362..3561468 1 NC_018658.1 COG0842 ABC-type multidrug transport system, permease component; hypothetical protein 3561468 13701615 O3K_17390 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780152.1 3560362 D 1133852 CDS YP_006780153.1 407483004 13701616 complement(3561430..3561840) 1 NC_018658.1 COG0843 Heme/copper-type cytochrome/quinol oxidases, subunit 1; hypothetical protein 3561840 13701616 O3K_17395 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780153.1 3561430 R 1133852 CDS YP_006780154.1 407483005 13701617 3561973..3562734 1 NC_018658.1 COG3568 Metal-dependent hydrolase; hypothetical protein 3562734 13701617 O3K_17400 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780154.1 3561973 D 1133852 CDS YP_006780155.1 407483006 13701618 3562731..3563972 1 NC_018658.1 COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipi n synthases and related enzymes; cardiolipin synthase 2 3563972 13701618 O3K_17405 Escherichia coli O104:H4 str. 2011C-3493 cardiolipin synthase 2 YP_006780155.1 3562731 D 1133852 CDS YP_006780156.1 407483007 13701619 3563972..3564928 1 NC_018658.1 COG0392 Predicted integral membrane protein; hypothetical protein 3564928 13701619 O3K_17410 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780156.1 3563972 D 1133852 CDS YP_006780157.1 407483008 13701620 complement(3564964..3565677) 1 NC_018658.1 COG0670 Integral membrane protein, interacts with FtsH; hypothetical protein 3565677 13701620 O3K_17415 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780157.1 3564964 R 1133852 CDS YP_006780158.1 407483009 13701621 complement(3565747..3566451) 1 NC_018658.1 COG0670 Integral membrane protein, interacts with FtsH; hypothetical protein 3566451 13701621 O3K_17420 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780158.1 3565747 R 1133852 CDS YP_006780159.1 407483010 13701622 complement(3566596..3567300) 1 NC_018658.1 COG0670 Integral membrane protein, interacts with FtsH; inner membrane protein 3567300 13701622 O3K_17425 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006780159.1 3566596 R 1133852 CDS YP_006780160.1 407483011 13701623 complement(3567437..3567889) 1 NC_018658.1 COG0314 Molybdopterin converting factor, large subunit; molybdopterin guanine dinucleotide biosynthesis protein MoaE 3567889 moaE 13701623 moaE Escherichia coli O104:H4 str. 2011C-3493 molybdopterin guanine dinucleotide biosynthesis protein MoaE YP_006780160.1 3567437 R 1133852 CDS YP_006780161.1 407483012 13701624 complement(3567891..3568136) 1 NC_018658.1 COG1977 Molybdopterin converting factor, small subunit; molybdopterin synthase small subunit 3568136 moaD 13701624 moaD Escherichia coli O104:H4 str. 2011C-3493 molybdopterin synthase small subunit YP_006780161.1 3567891 R 1133852 CDS YP_006780162.1 407483013 13701625 complement(3568129..3568614) 1 NC_018658.1 COG0315 Molybdenum cofactor biosynthesis enzyme; molybdenum cofactor biosynthesis protein MoaC 3568614 moaC 13701625 moaC Escherichia coli O104:H4 str. 2011C-3493 molybdenum cofactor biosynthesis protein MoaC YP_006780162.1 3568129 R 1133852 CDS YP_006780163.1 407483014 13701626 complement(3568617..3569129) 1 NC_018658.1 COG0521 Molybdopterin biosynthesis enzymes; molybdenum cofactor biosynthesis protein B 3569129 13701626 O3K_17445 Escherichia coli O104:H4 str. 2011C-3493 molybdenum cofactor biosynthesis protein B YP_006780163.1 3568617 R 1133852 CDS YP_006780164.1 407483015 13701627 complement(3569151..3570140) 1 NC_018658.1 COG2896 Molybdenum cofactor biosynthesis enzyme; molybdenum cofactor biosynthesis protein A 3570140 moaA 13701627 moaA Escherichia coli O104:H4 str. 2011C-3493 molybdenum cofactor biosynthesis protein A YP_006780164.1 3569151 R 1133852 CDS YP_006780165.1 407483016 13701628 3570537..3571445 1 NC_018658.1 structural protein; COG0391 Uncharacterized conserved protein; putative transferase with NAD(P)-binding Rossmann-fold domain 3571445 13701628 O3K_17455 Escherichia coli O104:H4 str. 2011C-3493 putative transferase with NAD(P)-binding Rossmann-fold domain YP_006780165.1 3570537 D 1133852 CDS YP_006780166.1 407483017 13701629 complement(3571637..3573658) 1 NC_018658.1 COG0556 Helicase subunit of the DNA excision repair complex; excinuclease ABC subunit B 3573658 13701629 O3K_17460 Escherichia coli O104:H4 str. 2011C-3493 excinuclease ABC subunit B YP_006780166.1 3571637 R 1133852 CDS YP_006780167.1 407483018 13701630 complement(3574237..3574914) 1 NC_018658.1 COG0132 Dethiobiotin synthetase; dithiobiotin synthetase 3574914 bioD 13701630 bioD Escherichia coli O104:H4 str. 2011C-3493 dithiobiotin synthetase YP_006780167.1 3574237 R 1133852 CDS YP_006780168.1 407483019 13701631 complement(3574907..3575662) 1 NC_018658.1 COG0500 SAM-dependent methyltransferases; biotin biosynthesis protein BioC 3575662 13701631 O3K_17470 Escherichia coli O104:H4 str. 2011C-3493 biotin biosynthesis protein BioC YP_006780168.1 3574907 R 1133852 CDS YP_006780169.1 407483020 13701632 complement(3575649..3576803) 1 NC_018658.1 COG0156 7-keto-8-aminopelargonate synthetase and related enzymes; 8-amino-7-oxononanoate synthase 3576803 13701632 O3K_17475 Escherichia coli O104:H4 str. 2011C-3493 8-amino-7-oxononanoate synthase YP_006780169.1 3575649 R 1133852 CDS YP_006780170.1 407483021 13701633 complement(3576800..3577840) 1 NC_018658.1 COG0502 Biotin synthase and related enzymes; biotin synthase 3577840 13701633 O3K_17480 Escherichia coli O104:H4 str. 2011C-3493 biotin synthase YP_006780170.1 3576800 R 1133852 CDS YP_006780171.1 407483022 13701634 3577927..3579216 1 NC_018658.1 COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; adenosylmethionine-8-amino-7-oxononanoate aminotransferase 3579216 13701634 O3K_17485 Escherichia coli O104:H4 str. 2011C-3493 adenosylmethionine-8-amino-7-oxononanoate aminotransferase YP_006780171.1 3577927 D 1133852 CDS YP_006780172.1 407483023 13701635 3579275..3579751 1 NC_018658.1 COG1881 Phospholipid-binding protein; putative kinase inhibitor protein 3579751 13701635 O3K_17490 Escherichia coli O104:H4 str. 2011C-3493 putative kinase inhibitor protein YP_006780172.1 3579275 D 1133852 CDS YP_006780173.1 407483024 13701717 3580497..3581828 1 NC_018658.1 COG2199 FOG: GGDEF domain; hypothetical protein 3581828 13701717 O3K_17495 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780173.1 3580497 D 1133852 CDS YP_006780174.1 407483025 13701718 complement(3581902..3582486) 1 NC_018658.1 tail fiber chaperone, Qin prophage 3582486 13701718 O3K_17500 Escherichia coli O104:H4 str. 2011C-3493 tail fiber chaperone, Qin prophage YP_006780174.1 3581902 R 1133852 CDS YP_006780175.1 407483026 13701719 complement(3582486..3584195) 1 NC_018658.1 putative phage tail fiber protein 3584195 13701719 O3K_17505 Escherichia coli O104:H4 str. 2011C-3493 putative phage tail fiber protein YP_006780175.1 3582486 R 1133852 CDS YP_006780176.1 407483027 13701720 3584173..3585063 1 NC_018658.1 hypothetical protein 3585063 13701720 O3K_17510 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780176.1 3584173 D 1133852 CDS YP_006780177.1 407483028 13701721 3585451..3585624 1 NC_018658.1 hypothetical protein 3585624 13701721 O3K_17515 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780177.1 3585451 D 1133852 CDS YP_006780178.1 407483029 13701722 complement(3585625..3586224) 1 NC_018658.1 Lom-like outer membrane protein of phage origin 3586224 13701722 O3K_17520 Escherichia coli O104:H4 str. 2011C-3493 Lom-like outer membrane protein of phage origin YP_006780178.1 3585625 R 1133852 CDS YP_006780179.1 407483030 13701723 complement(3586295..3589792) 1 NC_018658.1 COG4733 Phage-related protein, tail component; Host specificity protein J of prophage 3589792 13701723 O3K_17525 Escherichia coli O104:H4 str. 2011C-3493 Host specificity protein J of prophage YP_006780179.1 3586295 R 1133852 CDS YP_006780180.1 407483031 13701724 complement(3589853..3590524) 1 NC_018658.1 COG4723 Phage-related protein, tail component; Tail assembly protein I 3590524 13701724 O3K_17530 Escherichia coli O104:H4 str. 2011C-3493 Tail assembly protein I YP_006780180.1 3589853 R 1133852 CDS YP_006780181.1 407483032 13701725 complement(3590422..3591165) 1 NC_018658.1 COG1310 Predicted metal-dependent protease of the PAD1/JAB1 superfamily; tail fiber component K of prophage 3591165 13701725 O3K_17535 Escherichia coli O104:H4 str. 2011C-3493 tail fiber component K of prophage YP_006780181.1 3590422 R 1133852 CDS YP_006780182.1 407483033 13701726 complement(3591171..3591869) 1 NC_018658.1 COG4672 Phage-related protein; Minor tail protein L 3591869 13701726 O3K_17540 Escherichia coli O104:H4 str. 2011C-3493 Minor tail protein L YP_006780182.1 3591171 R 1133852 CDS YP_006780183.1 407483034 13701727 complement(3591869..3592198) 1 NC_018658.1 COG4718 Phage-related protein; minor tail protein 3592198 13701727 O3K_17545 Escherichia coli O104:H4 str. 2011C-3493 minor tail protein YP_006780183.1 3591869 R 1133852 CDS YP_006780184.1 407483035 13701728 complement(3592195..3594756) 1 NC_018658.1 Minor tail protein precursor H 3594756 13701728 O3K_17550 Escherichia coli O104:H4 str. 2011C-3493 Minor tail protein precursor H YP_006780184.1 3592195 R 1133852 CDS YP_006780185.1 407483036 13701729 complement(3594749..3595183) 1 NC_018658.1 putative minor tail protein 3595183 13701729 O3K_17555 Escherichia coli O104:H4 str. 2011C-3493 putative minor tail protein YP_006780185.1 3594749 R 1133852 CDS YP_006780186.1 407483037 13701730 complement(3595165..3595587) 1 NC_018658.1 Minor tail protein G 3595587 13701730 O3K_17560 Escherichia coli O104:H4 str. 2011C-3493 Minor tail protein G YP_006780186.1 3595165 R 1133852 CDS YP_006780187.1 407483038 13701731 complement(3595603..3596343) 1 NC_018658.1 COG5492 Bacterial surface proteins containing Ig-like domains; Major tail protein V 3596343 13701731 O3K_17565 Escherichia coli O104:H4 str. 2011C-3493 Major tail protein V YP_006780187.1 3595603 R 1133852 CDS YP_006780188.1 407483039 13701732 complement(3596351..3596746) 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; Minor tail protein U 3596746 13701732 O3K_17570 Escherichia coli O104:H4 str. 2011C-3493 Minor tail protein U YP_006780188.1 3596351 R 1133852 CDS YP_006780189.1 407483040 13701733 complement(3596743..3597321) 1 NC_018658.1 Minor tail protein Z (GpZ) 3597321 13701733 O3K_17575 Escherichia coli O104:H4 str. 2011C-3493 Minor tail protein Z (GpZ) YP_006780189.1 3596743 R 1133852 CDS YP_006780190.1 407483041 13701734 complement(3597333..3597686) 1 NC_018658.1 Tail attachment protein (Minor capsid protein FII) from bacteriophage origin 3597686 13701734 O3K_17580 Escherichia coli O104:H4 str. 2011C-3493 Tail attachment protein (Minor capsid protein FII) from bacteriophage origin YP_006780190.1 3597333 R 1133852 CDS YP_006780191.1 407483042 13701735 complement(3597698..3598093) 1 NC_018658.1 putative phage DNA packaging protein 3598093 13701735 O3K_17585 Escherichia coli O104:H4 str. 2011C-3493 putative phage DNA packaging protein YP_006780191.1 3597698 R 1133852 CDS YP_006780192.1 407483043 13701736 complement(3598135..3599160) 1 NC_018658.1 Major head coat protein from bacteriophage origin 3599160 13701736 O3K_17590 Escherichia coli O104:H4 str. 2011C-3493 Major head coat protein from bacteriophage origin YP_006780192.1 3598135 R 1133852 CDS YP_006780193.1 407483044 13701737 complement(3599216..3599548) 1 NC_018658.1 Head decoration protein from bacteriophage origin 3599548 13701737 O3K_17595 Escherichia coli O104:H4 str. 2011C-3493 Head decoration protein from bacteriophage origin YP_006780193.1 3599216 R 1133852 CDS YP_006780194.1 407483045 13701738 complement(3599558..3600877) 1 NC_018658.1 COG0616 Periplasmic serine proteases (ClpP class); Minor capsid protein C from bacteriophage origin 3600877 13701738 O3K_17600 Escherichia coli O104:H4 str. 2011C-3493 Minor capsid protein C from bacteriophage origin YP_006780194.1 3599558 R 1133852 CDS YP_006780195.1 407483046 13701739 complement(3600858..3602459) 1 NC_018658.1 COG5511 Bacteriophage capsid protein; phage portal protein, lambda family 3602459 13701739 O3K_17605 Escherichia coli O104:H4 str. 2011C-3493 phage portal protein, lambda family YP_006780195.1 3600858 R 1133852 CDS YP_006780196.1 407483047 13701740 complement(3602456..3602662) 1 NC_018658.1 Lambda prophage-derived head-to-tail joining protein W 3602662 13701740 O3K_17610 Escherichia coli O104:H4 str. 2011C-3493 Lambda prophage-derived head-to-tail joining protein W YP_006780196.1 3602456 R 1133852 CDS YP_006780197.1 407483048 13701741 complement(3602659..3602877) 1 NC_018658.1 bacteriophage tail assembly protein 3602877 13701741 O3K_17615 Escherichia coli O104:H4 str. 2011C-3493 bacteriophage tail assembly protein YP_006780197.1 3602659 R 1133852 CDS YP_006780198.1 407483049 13701742 complement(3602922..3604583) 1 NC_018658.1 COG5525 Bacteriophage tail assembly protein; Terminase large subunit from bacteriophage origin 3604583 13701742 O3K_17620 Escherichia coli O104:H4 str. 2011C-3493 Terminase large subunit from bacteriophage origin YP_006780198.1 3602922 R 1133852 CDS YP_006780199.1 407483050 13701743 complement(3604558..3605103) 1 NC_018658.1 COG4220 Phage DNA packaging protein, Nu1 subunit of terminase; terminase small subunit 3605103 13701743 O3K_17625 Escherichia coli O104:H4 str. 2011C-3493 terminase small subunit YP_006780199.1 3604558 R 1133852 CDS YP_006780200.1 407483051 13701744 3605492..3605725 1 NC_018658.1 Qin prophage 3605725 13701744 O3K_17630 Escherichia coli O104:H4 str. 2011C-3493 Qin prophage YP_006780200.1 3605492 D 1133852 CDS YP_006780201.1 407483052 13701745 3605782..3606192 1 NC_018658.1 COG5562 Phage envelope protein; phage protein 3606192 13701745 O3K_17635 Escherichia coli O104:H4 str. 2011C-3493 phage protein YP_006780201.1 3605782 D 1133852 CDS YP_006780202.1 407483053 13701746 complement(3606542..3607063) 1 NC_018658.1 phage protein 3607063 13701746 O3K_17640 Escherichia coli O104:H4 str. 2011C-3493 phage protein YP_006780202.1 3606542 R 1133852 CDS YP_006780203.1 407483054 13701747 complement(3607268..3607705) 1 NC_018658.1 bacteriophage lysis protein 3607705 13701747 O3K_17645 Escherichia coli O104:H4 str. 2011C-3493 bacteriophage lysis protein YP_006780203.1 3607268 R 1133852 CDS YP_006780204.1 407483055 13701748 complement(3607702..3608199) 1 NC_018658.1 COG3772 Phage-related lysozyme (muraminidase); lysozyme, DLP12 prophage 3608199 13701748 O3K_17650 Escherichia coli O104:H4 str. 2011C-3493 lysozyme, DLP12 prophage YP_006780204.1 3607702 R 1133852 CDS YP_006780205.1 407483056 13701749 complement(3608199..3608414) 1 NC_018658.1 phage lysis protein 3608414 13701749 O3K_17655 Escherichia coli O104:H4 str. 2011C-3493 phage lysis protein YP_006780205.1 3608199 R 1133852 CDS YP_006780206.1 407483057 13701750 3609003..3610085 1 NC_018658.1 COG3203 Outer membrane protein (porin); outer membrane porin, DLP12 prophage 3610085 13701750 O3K_17660 Escherichia coli O104:H4 str. 2011C-3493 outer membrane porin, DLP12 prophage YP_006780206.1 3609003 D 1133852 CDS YP_006780207.1 407483058 13701751 complement(3610274..3610657) 1 NC_018658.1 antitermination protein Q 3610657 13701751 O3K_17665 Escherichia coli O104:H4 str. 2011C-3493 antitermination protein Q YP_006780207.1 3610274 R 1133852 CDS YP_006780208.1 407483059 13701752 complement(3610743..3610883) 1 NC_018658.1 hypothetical protein 3610883 13701752 O3K_17670 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780208.1 3610743 R 1133852 CDS YP_006780209.1 407483060 13701753 complement(3610880..3611107) 1 NC_018658.1 COG4570 Holliday junction resolvase; endodeoxyribonuclease RUS 3611107 13701753 O3K_17675 Escherichia coli O104:H4 str. 2011C-3493 endodeoxyribonuclease RUS YP_006780209.1 3610880 R 1133852 CDS YP_006780210.1 407483061 13701754 complement(3611238..3611528) 1 NC_018658.1 hypothetical protein 3611528 13701754 O3K_17680 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780210.1 3611238 R 1133852 CDS YP_006780211.1 407483062 13701755 complement(3611521..3611691) 1 NC_018658.1 prophage protein NinE 3611691 13701755 O3K_17685 Escherichia coli O104:H4 str. 2011C-3493 prophage protein NinE YP_006780211.1 3611521 R 1133852 CDS YP_006780212.1 407483063 13701756 complement(3611691..3612146) 1 NC_018658.1 hypothetical protein 3612146 13701756 O3K_17690 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780212.1 3611691 R 1133852 CDS YP_006780213.1 407483064 13701757 complement(3612341..3612847) 1 NC_018658.1 hypothetical protein 3612847 13701757 O3K_17695 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780213.1 3612341 R 1133852 CDS YP_006780214.1 407483065 13701758 complement(3613169..3613408) 1 NC_018658.1 antirepressor protein 3613408 13701758 O3K_17700 Escherichia coli O104:H4 str. 2011C-3493 antirepressor protein YP_006780214.1 3613169 R 1133852 CDS YP_006780215.1 407483066 13701759 complement(3613520..3614314) 1 NC_018658.1 COG1961 Site-specific recombinases, DNA invertase Pin homologs; putative phage recombinase 3614314 13701759 O3K_17705 Escherichia coli O104:H4 str. 2011C-3493 putative phage recombinase YP_006780215.1 3613520 R 1133852 CDS YP_006780216.1 407483067 13701760 complement(3614271..3614513) 1 NC_018658.1 COG2076 Membrane transporters of cations and cationic drugs; multidrug efflux protein 3614513 emrE 13701760 emrE Escherichia coli O104:H4 str. 2011C-3493 multidrug efflux protein YP_006780216.1 3614271 R 1133852 CDS YP_006780217.1 407483068 13701761 complement(3614560..3614862) 1 NC_018658.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Ren protein from phage origin 3614862 13701761 O3K_17715 Escherichia coli O104:H4 str. 2011C-3493 Ren protein from phage origin YP_006780217.1 3614560 R 1133852 CDS YP_006780218.1 407483069 13701762 complement(3614859..3615560) 1 NC_018658.1 replication protein P of bacteriophage 3615560 13701762 O3K_17720 Escherichia coli O104:H4 str. 2011C-3493 replication protein P of bacteriophage YP_006780218.1 3614859 R 1133852 CDS YP_006780219.1 407483070 13701763 complement(3615557..3616486) 1 NC_018658.1 Replication protein O frm phage origin 3616486 13701763 O3K_17725 Escherichia coli O104:H4 str. 2011C-3493 Replication protein O frm phage origin YP_006780219.1 3615557 R 1133852 CDS YP_006780220.1 407483071 13701764 complement(3616573..3617112) 1 NC_018658.1 Regulatory protein CII (modular protein) from bacteriophage origin, coiled-coil 3617112 13701764 O3K_17730 Escherichia coli O104:H4 str. 2011C-3493 Regulatory protein CII (modular protein) from bacteriophage origin, coiled-coil YP_006780220.1 3616573 R 1133852 CDS YP_006780221.1 407483072 13701765 complement(3617182..3617412) 1 NC_018658.1 phage regulatory protein Cro 3617412 13701765 O3K_17735 Escherichia coli O104:H4 str. 2011C-3493 phage regulatory protein Cro YP_006780221.1 3617182 R 1133852 CDS YP_006780222.1 407483073 13701766 3617518..3618207 1 NC_018658.1 COG2932 Predicted transcriptional regulator; phage repressor protein CI 3618207 13701766 O3K_17740 Escherichia coli O104:H4 str. 2011C-3493 phage repressor protein CI YP_006780222.1 3617518 D 1133852 CDS YP_006780223.1 407483074 13701767 3618805..3619011 1 NC_018658.1 putative prophage Kil protein 3619011 13701767 O3K_17745 Escherichia coli O104:H4 str. 2011C-3493 putative prophage Kil protein YP_006780223.1 3618805 D 1133852 CDS YP_006780224.1 407483075 13701768 3619087..3619383 1 NC_018658.1 host-nuclease inhibitor protein Gam of bacteriophage 3619383 13701768 O3K_17750 Escherichia coli O104:H4 str. 2011C-3493 host-nuclease inhibitor protein Gam of bacteriophage YP_006780224.1 3619087 D 1133852 CDS YP_006780225.1 407483076 13701769 3619389..3620174 1 NC_018658.1 COG0488 ATPase components of ABC transporters with duplicated ATPase domains; Bet protein 3620174 13701769 O3K_17755 Escherichia coli O104:H4 str. 2011C-3493 Bet protein YP_006780225.1 3619389 D 1133852 CDS YP_006780226.1 407483077 13701770 3620171..3620851 1 NC_018658.1 exonuclease from phage origin 3620851 13701770 O3K_17760 Escherichia coli O104:H4 str. 2011C-3493 exonuclease from phage origin YP_006780226.1 3620171 D 1133852 CDS YP_006780227.1 407483078 13701771 3620842..3621030 1 NC_018658.1 hypothetical protein 3621030 13701771 O3K_17765 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780227.1 3620842 D 1133852 CDS YP_006780228.1 407483079 13701772 3621003..3621194 1 NC_018658.1 phage protein 3621194 13701772 O3K_17770 Escherichia coli O104:H4 str. 2011C-3493 phage protein YP_006780228.1 3621003 D 1133852 CDS YP_006780229.1 407483080 13701773 3621191..3621274 1 NC_018658.1 hypothetical protein 3621274 13701773 O3K_17775 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780229.1 3621191 D 1133852 CDS YP_006780230.1 407483081 13701774 3621205..3621486 1 NC_018658.1 hypothetical protein 3621486 13701774 O3K_17780 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780230.1 3621205 D 1133852 CDS YP_006780231.1 407483082 13701775 3621585..3621806 1 NC_018658.1 COG1734 DnaK suppressor protein; hypothetical protein 3621806 13701775 O3K_17785 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780231.1 3621585 D 1133852 CDS YP_006780232.1 407483083 13701776 complement(3622017..3622547) 1 NC_018658.1 hypothetical protein 3622547 13701776 O3K_17790 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780232.1 3622017 R 1133852 CDS YP_006780233.1 407483084 13701777 3622862..3623029 1 NC_018658.1 hypothetical protein 3623029 13701777 O3K_17795 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780233.1 3622862 D 1133852 CDS YP_006780234.1 407483085 13701778 3623069..3623287 1 NC_018658.1 Excisionase 3623287 13701778 O3K_17800 Escherichia coli O104:H4 str. 2011C-3493 Excisionase YP_006780234.1 3623069 D 1133852 CDS YP_006780235.1 407483086 13701779 3623265..3624335 1 NC_018658.1 COG0582 Integrase; Integrase from phage 3624335 13701779 O3K_17805 Escherichia coli O104:H4 str. 2011C-3493 Integrase from phage YP_006780235.1 3623265 D 1133852 CDS YP_006780236.1 407483087 13701780 3624470..3625753 1 NC_018658.1 COG4677 Pectin methylesterase; acyl-CoA thioesterase 3625753 13701780 O3K_17810 Escherichia coli O104:H4 str. 2011C-3493 acyl-CoA thioesterase YP_006780236.1 3624470 D 1133852 CDS YP_006780237.1 407483088 13701781 complement(3625987..3628248) 1 NC_018658.1 COG1048 Aconitase A; putative hydratase 3628248 13701781 O3K_17815 Escherichia coli O104:H4 str. 2011C-3493 putative hydratase YP_006780237.1 3625987 R 1133852 CDS YP_006780238.1 407483089 13701782 complement(3628431..3629864) 1 NC_018658.1 COG0471 Di- and tricarboxylate transporters; transporter 3629864 13701782 O3K_17820 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006780238.1 3628431 R 1133852 CDS YP_006780239.1 407483090 13701783 complement(3629940..3630992) 1 NC_018658.1 COG2828 Uncharacterized protein conserved in bacteria; hypothetical protein 3630992 13701783 O3K_17825 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780239.1 3629940 R 1133852 CDS YP_006780240.1 407483091 13701784 3631176..3632129 1 NC_018658.1 COG0583 Transcriptional regulator; putative DNA-binding transcriptional regulator 3632129 13701784 O3K_17830 Escherichia coli O104:H4 str. 2011C-3493 putative DNA-binding transcriptional regulator YP_006780240.1 3631176 D 1133852 CDS YP_006780241.1 407483092 13701785 complement(3632170..3633165) 1 NC_018658.1 COG2706 3-carboxymuconate cyclase; 6-phosphogluconolactonase 3633165 13701785 O3K_17835 Escherichia coli O104:H4 str. 2011C-3493 6-phosphogluconolactonase YP_006780241.1 3632170 R 1133852 CDS YP_006780242.1 407483093 13701786 3633320..3634138 1 NC_018658.1 COG0561 Predicted hydrolases of the HAD superfamily; pyridoxal phosphate (PLP) phosphatase 3634138 13701786 O3K_17840 Escherichia coli O104:H4 str. 2011C-3493 pyridoxal phosphate (PLP) phosphatase YP_006780242.1 3633320 D 1133852 CDS YP_006780243.1 407483094 13701868 complement(3634139..3635197) 1 NC_018658.1 COG4148 ABC-type molybdate transport system, ATPase component; molybdate transporter ATP-binding protein 3635197 modC 13701868 modC Escherichia coli O104:H4 str. 2011C-3493 molybdate transporter ATP-binding protein YP_006780243.1 3634139 R 1133852 CDS YP_006780244.1 407483095 13701869 complement(3635200..3635889) 1 NC_018658.1 COG4149 ABC-type molybdate transport system, permease component; molybdate ABC transporter permease 3635889 modB 13701869 modB Escherichia coli O104:H4 str. 2011C-3493 molybdate ABC transporter permease YP_006780244.1 3635200 R 1133852 CDS YP_006780245.1 407483096 13701870 complement(3635889..3636662) 1 NC_018658.1 COG0725 ABC-type molybdate transport system, periplasmic component; molybdate transporter periplasmic protein 3636662 modA 13701870 modA Escherichia coli O104:H4 str. 2011C-3493 molybdate transporter periplasmic protein YP_006780245.1 3635889 R 1133852 CDS YP_006780246.1 407483097 13701871 complement(3636829..3636978) 1 NC_018658.1 hypothetical protein 3636978 13701871 O3K_17860 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780246.1 3636829 R 1133852 CDS YP_006780247.1 407483098 13701872 3637107..3637895 1 NC_018658.1 COG2005 N-terminal domain of molybdenum-binding protein; DNA-binding transcriptional regulator ModE 3637895 13701872 O3K_17865 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator ModE YP_006780247.1 3637107 D 1133852 CDS YP_006780248.1 407483099 13701873 3637963..3639435 1 NC_018658.1 COG1119 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA; putative molybdenum transport ATP-binding protein ModF 3639435 13701873 O3K_17870 Escherichia coli O104:H4 str. 2011C-3493 putative molybdenum transport ATP-binding protein ModF YP_006780248.1 3637963 D 1133852 CDS YP_006780249.1 407483100 13701874 3639696..3640712 1 NC_018658.1 COG1087 UDP-glucose 4-epimerase; UDP-galactose-4-epimerase 3640712 13701874 O3K_17875 Escherichia coli O104:H4 str. 2011C-3493 UDP-galactose-4-epimerase YP_006780249.1 3639696 D 1133852 CDS YP_006780250.1 407483101 13701875 3640722..3641768 1 NC_018658.1 COG1085 Galactose-1-phosphate uridylyltransferase; galactose-1-phosphate uridylyltransferase 3641768 13701875 O3K_17880 Escherichia coli O104:H4 str. 2011C-3493 galactose-1-phosphate uridylyltransferase YP_006780250.1 3640722 D 1133852 CDS YP_006780251.1 407483102 13701876 3641772..3642920 1 NC_018658.1 COG0153 Galactokinase; galactokinase 3642920 13701876 O3K_17885 Escherichia coli O104:H4 str. 2011C-3493 galactokinase YP_006780251.1 3641772 D 1133852 CDS YP_006780252.1 407483103 13701877 3642914..3643954 1 NC_018658.1 COG2017 Galactose mutarotase and related enzymes; galactose-1-epimerase 3643954 galM 13701877 galM Escherichia coli O104:H4 str. 2011C-3493 galactose-1-epimerase YP_006780252.1 3642914 D 1133852 CDS YP_006780253.1 407483104 13701878 3644159..3644911 1 NC_018658.1 COG0588 Phosphoglycerate mutase 1; phosphoglyceromutase 3644911 gpmA 13701878 gpmA Escherichia coli O104:H4 str. 2011C-3493 phosphoglyceromutase YP_006780253.1 3644159 D 1133852 CDS YP_006780254.1 407483105 13701879 complement(3645069..3646121) 1 NC_018658.1 COG0722 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; phospho-2-dehydro-3-deoxyheptonate aldolase 3646121 13701879 O3K_17900 Escherichia coli O104:H4 str. 2011C-3493 phospho-2-dehydro-3-deoxyheptonate aldolase YP_006780254.1 3645069 R 1133852 CDS YP_006780255.1 407483106 13701880 3646437..3646817 1 NC_018658.1 hypothetical protein 3646817 13701880 O3K_17905 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780255.1 3646437 D 1133852 CDS YP_006780256.1 407483107 13701881 3646931..3647872 1 NC_018658.1 COG1230 Co/Zn/Cd efflux system component; zinc transporter ZitB 3647872 13701881 O3K_17910 Escherichia coli O104:H4 str. 2011C-3493 zinc transporter ZitB YP_006780256.1 3646931 D 1133852 CDS YP_006780257.1 407483108 13701882 complement(3647869..3648588) 1 NC_018658.1 COG3201 Nicotinamide mononucleotide transporter; nicotinamide riboside transporter PnuC 3648588 13701882 O3K_17915 Escherichia coli O104:H4 str. 2011C-3493 nicotinamide riboside transporter PnuC YP_006780257.1 3647869 R 1133852 CDS YP_006780258.1 407483109 13701883 complement(3648626..3649669) 1 NC_018658.1 COG0379 Quinolinate synthase; quinolinate synthetase 3649669 13701883 O3K_17920 Escherichia coli O104:H4 str. 2011C-3493 quinolinate synthetase YP_006780258.1 3648626 R 1133852 CDS YP_006780259.1 407483110 13701891 complement(3651138..3651929) 1 NC_018658.1 COG1729 Uncharacterized protein conserved in bacteria; tol-pal system protein YbgF 3651929 13701891 O3K_17925 Escherichia coli O104:H4 str. 2011C-3493 tol-pal system protein YbgF YP_006780259.1 3651138 R 1133852 CDS YP_006780260.1 407483111 13701892 complement(3651939..3652460) 1 NC_018658.1 COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins; peptidoglycan-associated outer membrane lipoprotein 3652460 13701892 O3K_17930 Escherichia coli O104:H4 str. 2011C-3493 peptidoglycan-associated outer membrane lipoprotein YP_006780260.1 3651939 R 1133852 CDS YP_006780261.1 407483112 13701893 complement(3652495..3653787) 1 NC_018658.1 COG0823 Periplasmic component of the Tol biopolymer transport system; translocation protein TolB 3653787 tolB 13701893 tolB Escherichia coli O104:H4 str. 2011C-3493 translocation protein TolB YP_006780261.1 3652495 R 1133852 CDS YP_006780262.1 407483113 13701894 complement(3653920..3655185) 1 NC_018658.1 COG3064 Membrane protein involved in colicin uptake; cell envelope integrity inner membrane protein TolA 3655185 tolA 13701894 tolA Escherichia coli O104:H4 str. 2011C-3493 cell envelope integrity inner membrane protein TolA YP_006780262.1 3653920 R 1133852 CDS YP_006780263.1 407483114 13701895 complement(3655250..3655678) 1 NC_018658.1 COG0848 Biopolymer transport protein; colicin uptake protein TolR 3655678 13701895 O3K_17945 Escherichia coli O104:H4 str. 2011C-3493 colicin uptake protein TolR YP_006780263.1 3655250 R 1133852 CDS YP_006780264.1 407483115 13701896 complement(3655682..3656374) 1 NC_018658.1 COG0811 Biopolymer transport proteins; colicin uptake protein TolQ 3656374 13701896 O3K_17950 Escherichia coli O104:H4 str. 2011C-3493 colicin uptake protein TolQ YP_006780264.1 3655682 R 1133852 CDS YP_006780265.1 407483116 13701897 complement(3656371..3656775) 1 NC_018658.1 COG0824 Predicted thioesterase; acyl-CoA thioesterase YbgC 3656775 13701897 O3K_17955 Escherichia coli O104:H4 str. 2011C-3493 acyl-CoA thioesterase YbgC YP_006780265.1 3656371 R 1133852 CDS YP_006780266.1 407483117 13701898 complement(3656925..3657218) 1 NC_018658.1 COG3790 Predicted membrane protein; hypothetical protein 3657218 13701898 O3K_17960 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780266.1 3656925 R 1133852 CDS YP_006780267.1 407483118 13701899 complement(3657218..3657331) 1 NC_018658.1 COG4890 Predicted outer membrane lipoprotein; cyd operon protein YbgT 3657331 13701899 O3K_17965 Escherichia coli O104:H4 str. 2011C-3493 cyd operon protein YbgT YP_006780267.1 3657218 R 1133852 CDS YP_006780268.1 407483119 13701900 complement(3657346..3658485) 1 NC_018658.1 COG1294 Cytochrome bd-type quinol oxidase, subunit 2; cytochrome d ubiquinol oxidase subunit 2 3658485 13701900 O3K_17970 Escherichia coli O104:H4 str. 2011C-3493 cytochrome d ubiquinol oxidase subunit 2 YP_006780268.1 3657346 R 1133852 CDS YP_006780269.1 407483120 13701901 complement(3658501..3660069) 1 NC_018658.1 COG1271 Cytochrome bd-type quinol oxidase, subunit 1; cytochrome d terminal oxidase subunit 1 3660069 13701901 O3K_17975 Escherichia coli O104:H4 str. 2011C-3493 cytochrome d terminal oxidase subunit 1 YP_006780269.1 3658501 R 1133852 CDS YP_006780270.1 407483121 13701902 complement(3660664..3660891) 1 NC_018658.1 hypothetical protein 3660891 13701902 O3K_17980 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780270.1 3660664 R 1133852 CDS YP_006780271.1 407483122 13701903 complement(3660916..3663549) 1 NC_018658.1 COG0383 Alpha-mannosidase; alpha-mannosidase 3663549 13701903 O3K_17985 Escherichia coli O104:H4 str. 2011C-3493 alpha-mannosidase YP_006780271.1 3660916 R 1133852 CDS YP_006780272.1 407483123 13701904 complement(3663567..3665543) 1 NC_018658.1 COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type); PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC 3665543 13701904 O3K_17990 Escherichia coli O104:H4 str. 2011C-3493 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC YP_006780272.1 3663567 R 1133852 CDS YP_006780273.1 407483124 13701905 3665652..3666374 1 NC_018658.1 COG2188 Transcriptional regulators; DNA-binding transcriptional repressor MngR 3666374 13701905 O3K_17995 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional repressor MngR YP_006780273.1 3665652 D 1133852 CDS YP_006780274.1 407483125 13701906 complement(3666478..3667347) 1 NC_018658.1 COG0074 Succinyl-CoA synthetase, alpha subunit; succinyl-CoA synthetase subunit alpha 3667347 13701906 O3K_18000 Escherichia coli O104:H4 str. 2011C-3493 succinyl-CoA synthetase subunit alpha YP_006780274.1 3666478 R 1133852 CDS YP_006780275.1 407483126 13701907 complement(3667347..3668513) 1 NC_018658.1 COG0045 Succinyl-CoA synthetase, beta subunit; succinyl-CoA synthetase subunit beta 3668513 sucC 13701907 sucC Escherichia coli O104:H4 str. 2011C-3493 succinyl-CoA synthetase subunit beta YP_006780275.1 3667347 R 1133852 CDS YP_006780276.1 407483127 13701908 complement(3668607..3669824) 1 NC_018658.1 COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes; dihydrolipoamide succinyltransferase 3669824 13701908 O3K_18010 Escherichia coli O104:H4 str. 2011C-3493 dihydrolipoamide succinyltransferase YP_006780276.1 3668607 R 1133852 CDS YP_006780277.1 407483128 13701909 complement(3669839..3672640) 1 NC_018658.1 COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes; 2-oxoglutarate dehydrogenase E1 component 3672640 sucA 13701909 sucA Escherichia coli O104:H4 str. 2011C-3493 2-oxoglutarate dehydrogenase E1 component YP_006780277.1 3669839 R 1133852 CDS YP_006780278.1 407483129 13701910 complement(3672841..3673557) 1 NC_018658.1 COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit; succinate dehydrogenase iron-sulfur subunit 3673557 sdhB 13701910 sdhB Escherichia coli O104:H4 str. 2011C-3493 succinate dehydrogenase iron-sulfur subunit YP_006780278.1 3672841 R 1133852 CDS YP_006780279.1 407483130 13701911 complement(3673573..3675339) 1 NC_018658.1 COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; succinate dehydrogenase flavoprotein subunit 3675339 sdhA 13701911 sdhA Escherichia coli O104:H4 str. 2011C-3493 succinate dehydrogenase flavoprotein subunit YP_006780279.1 3673573 R 1133852 CDS YP_006780280.1 407483131 13701912 complement(3675339..3675686) 1 NC_018658.1 COG2142 Succinate dehydrogenase, hydrophobic anchor subunit; succinate dehydrogenase cytochrome b556 small membrane subunit 3675686 sdhD 13701912 sdhD Escherichia coli O104:H4 str. 2011C-3493 succinate dehydrogenase cytochrome b556 small membrane subunit YP_006780280.1 3675339 R 1133852 CDS YP_006780281.1 407483132 13701913 complement(3675680..3676069) 1 NC_018658.1 COG2009 Succinate dehydrogenase/fumarate reductase, cytochrome b subunit; succinate dehydrogenase cytochrome b556 large membrane subunit 3676069 sdhC 13701913 sdhC Escherichia coli O104:H4 str. 2011C-3493 succinate dehydrogenase cytochrome b556 large membrane subunit YP_006780281.1 3675680 R 1133852 CDS YP_006780282.1 407483133 13701914 complement(3676605..3676790) 1 NC_018658.1 hypothetical protein 3676790 13701914 O3K_18040 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780282.1 3676605 R 1133852 CDS YP_006780283.1 407483134 13701915 3676778..3678061 1 NC_018658.1 COG0372 Citrate synthase; type II citrate synthase 3678061 gltA 13701915 gltA Escherichia coli O104:H4 str. 2011C-3493 type II citrate synthase YP_006780283.1 3676778 D 1133852 CDS YP_006780284.1 407483135 13701916 3678451..3679017 1 NC_018658.1 COG3539 P pilus assembly protein, pilin FimA; putative fimbrial-like protein 3679017 13701916 O3K_18050 Escherichia coli O104:H4 str. 2011C-3493 putative fimbrial-like protein YP_006780284.1 3678451 D 1133852 CDS YP_006780285.1 407483136 13701917 3679077..3679325 1 NC_018658.1 COG3188 P pilus assembly protein, porin PapC; fimbrial biogenesis outer membrane usher protein 3679325 13701917 O3K_18055 Escherichia coli O104:H4 str. 2011C-3493 fimbrial biogenesis outer membrane usher protein YP_006780285.1 3679077 D 1133852 CDS YP_006780286.1 407483137 13701918 3679354..3679629 1 NC_018658.1 COG3677 Transposase and inactivated derivatives; InsA 3679629 13701918 O3K_18060 Escherichia coli O104:H4 str. 2011C-3493 InsA YP_006780286.1 3679354 D 1133852 CDS YP_006780287.1 407483138 13701919 3679548..3680051 1 NC_018658.1 COG1662 Transposase and inactivated derivatives, IS1 family; IS1 transposase InsAB' 3680051 13701919 O3K_18065 Escherichia coli O104:H4 str. 2011C-3493 IS1 transposase InsAB' YP_006780287.1 3679548 D 1133852 CDS YP_006780288.1 407483139 13701920 3680086..3680736 1 NC_018658.1 hypothetical protein 3680736 13701920 O3K_18070 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780288.1 3680086 D 1133852 CDS YP_006780289.1 407483140 13701921 3680888..3681934 1 NC_018658.1 COG3180 Putative ammonia monooxygenase; transport protein 3681934 13701921 O3K_18075 Escherichia coli O104:H4 str. 2011C-3493 transport protein YP_006780289.1 3680888 D 1133852 CDS YP_006780290.1 407483141 13701922 complement(3681931..3682722) 1 NC_018658.1 COG0266 Formamidopyrimidine-DNA glycosylase; endonuclease VIII 3682722 13701922 O3K_18080 Escherichia coli O104:H4 str. 2011C-3493 endonuclease VIII YP_006780290.1 3681931 R 1133852 CDS YP_006780291.1 407483142 13701923 complement(3682758..3683492) 1 NC_018658.1 COG1540 Uncharacterized proteins, homologs of lactam utilization protein B; LamB/YcsF family protein 3683492 13701923 O3K_18085 Escherichia coli O104:H4 str. 2011C-3493 LamB/YcsF family protein YP_006780291.1 3682758 R 1133852 CDS YP_006780292.1 407483143 13701924 complement(3683482..3684414) 1 NC_018658.1 COG1984 Allophanate hydrolase subunit 2; hydrolase subunit 3684414 13701924 O3K_18090 Escherichia coli O104:H4 str. 2011C-3493 hydrolase subunit YP_006780292.1 3683482 R 1133852 CDS YP_006780293.1 407483144 13701925 complement(3684408..3685064) 1 NC_018658.1 COG2049 Allophanate hydrolase subunit 1; carboxylase 3685064 13701925 O3K_18095 Escherichia coli O104:H4 str. 2011C-3493 carboxylase YP_006780293.1 3684408 R 1133852 CDS YP_006780294.1 407483145 13701926 complement(3685087..3685830) 1 NC_018658.1 COG0327 Uncharacterized conserved protein; metal-binding protein 3685830 13701926 O3K_18100 Escherichia coli O104:H4 str. 2011C-3493 metal-binding protein YP_006780294.1 3685087 R 1133852 CDS YP_006780295.1 407483146 13701927 3686101..3687582 1 NC_018658.1 COG3104 Dipeptide/tripeptide permease; dipeptide/tripeptide permease D 3687582 13701927 O3K_18105 Escherichia coli O104:H4 str. 2011C-3493 dipeptide/tripeptide permease D YP_006780295.1 3686101 D 1133852 CDS YP_006780296.1 407483147 13701928 complement(3687624..3689042) 1 NC_018658.1 COG0415 Deoxyribodipyrimidine photolyase; deoxyribodipyrimidine photolyase 3689042 13701928 O3K_18110 Escherichia coli O104:H4 str. 2011C-3493 deoxyribodipyrimidine photolyase YP_006780296.1 3687624 R 1133852 CDS YP_006780297.1 407483148 13701929 complement(3689039..3689548) 1 NC_018658.1 COG3272 Uncharacterized conserved protein; hypothetical protein 3689548 13701929 O3K_18115 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780297.1 3689039 R 1133852 CDS YP_006780298.1 407483149 13701930 complement(3689696..3690364) 1 NC_018658.1 COG5433 Transposase; hypothetical protein 3690364 13701930 O3K_18120 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780298.1 3689696 R 1133852 CDS YP_006780299.1 407483150 13701931 complement(3690583..3690837) 1 NC_018658.1 COG5433 Transposase; transposase 3690837 13701931 O3K_18125 Escherichia coli O104:H4 str. 2011C-3493 transposase YP_006780299.1 3690583 R 1133852 CDS YP_006780300.1 407483151 13701932 complement(3691063..3691632) 1 NC_018658.1 hypothetical protein 3691632 13701932 O3K_18130 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780300.1 3691063 R 1133852 CDS YP_006780301.1 407483152 13701933 complement(3691629..3693062) 1 NC_018658.1 COG3209 Rhs family protein; RhsC core protein 3693062 13701933 O3K_18135 Escherichia coli O104:H4 str. 2011C-3493 RhsC core protein YP_006780301.1 3691629 R 1133852 CDS YP_006780302.1 407483153 13701934 complement(3693180..3693506) 1 NC_018658.1 hypothetical protein 3693506 13701934 O3K_18140 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780302.1 3693180 R 1133852 CDS YP_006780303.1 407483154 13701935 complement(3693506..3697699) 1 NC_018658.1 COG3209 Rhs family protein; rhsC element core protein RshC 3697699 13701935 O3K_18145 Escherichia coli O104:H4 str. 2011C-3493 rhsC element core protein RshC YP_006780303.1 3693506 R 1133852 CDS YP_006780304.1 407483155 13701936 complement(3697942..3698148) 1 NC_018658.1 hypothetical protein 3698148 13701936 O3K_18150 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780304.1 3697942 R 1133852 CDS YP_006780305.1 407483156 13701937 3698461..3698550 1 NC_018658.1 potassium ion accessory transporter subunit 3698550 13701937 O3K_18155 Escherichia coli O104:H4 str. 2011C-3493 potassium ion accessory transporter subunit YP_006780305.1 3698461 D 1133852 CDS YP_006780306.1 407483157 13702019 3698550..3700223 1 NC_018658.1 COG2060 K+-transporting ATPase, A chain; potassium-transporting ATPase subunit A 3700223 13702019 O3K_18160 Escherichia coli O104:H4 str. 2011C-3493 potassium-transporting ATPase subunit A YP_006780306.1 3698550 D 1133852 CDS YP_006780307.1 407483158 13702020 3700246..3702294 1 NC_018658.1 COG2216 High-affinity K+ transport system, ATPase chain B; potassium-transporting ATPase subunit B 3702294 13702020 O3K_18165 Escherichia coli O104:H4 str. 2011C-3493 potassium-transporting ATPase subunit B YP_006780307.1 3700246 D 1133852 CDS YP_006780308.1 407483159 13702021 3702303..3702875 1 NC_018658.1 COG2156 K+-transporting ATPase, c chain; potassium-transporting ATPase subunit C 3702875 13702021 O3K_18170 Escherichia coli O104:H4 str. 2011C-3493 potassium-transporting ATPase subunit C YP_006780308.1 3702303 D 1133852 CDS YP_006780309.1 407483160 13702022 3702868..3705552 1 NC_018658.1 COG2205 Osmosensitive K+ channel histidine kinase; sensor protein KdpD 3705552 13702022 O3K_18175 Escherichia coli O104:H4 str. 2011C-3493 sensor protein KdpD YP_006780309.1 3702868 D 1133852 CDS YP_006780310.1 407483161 13702023 3705549..3706226 1 NC_018658.1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; DNA-binding transcriptional activator KdpE 3706226 13702023 O3K_18180 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional activator KdpE YP_006780310.1 3705549 D 1133852 CDS YP_006780311.1 407483162 13702024 3706916..3709114 1 NC_018658.1 COG1982 Arginine/lysine/ornithine decarboxylases; ornithine decarboxylase 3709114 13702024 O3K_18185 Escherichia coli O104:H4 str. 2011C-3493 ornithine decarboxylase YP_006780311.1 3706916 D 1133852 CDS YP_006780312.1 407483163 13702025 3709111..3710430 1 NC_018658.1 COG0531 Amino acid transporters; putrescine transporter 3710430 potE 13702025 potE Escherichia coli O104:H4 str. 2011C-3493 putrescine transporter YP_006780312.1 3709111 D 1133852 CDS YP_006780313.1 407483164 13702026 complement(3710486..3712126) 1 NC_018658.1 COG0033 Phosphoglucomutase; phosphoglucomutase 3712126 13702026 O3K_18195 Escherichia coli O104:H4 str. 2011C-3493 phosphoglucomutase YP_006780313.1 3710486 R 1133852 CDS YP_006780314.1 407483165 13702027 complement(3712152..3712697) 1 NC_018658.1 COG3057 Negative regulator of replication initiationR; replication initiation regulator SeqA 3712697 13702027 O3K_18200 Escherichia coli O104:H4 str. 2011C-3493 replication initiation regulator SeqA YP_006780314.1 3712152 R 1133852 CDS YP_006780315.1 407483166 13702028 3712882..3713646 1 NC_018658.1 COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily); acyl-CoA esterase 3713646 13702028 O3K_18205 Escherichia coli O104:H4 str. 2011C-3493 acyl-CoA esterase YP_006780315.1 3712882 D 1133852 CDS YP_006780316.1 407483167 13702029 3713786..3714079 1 NC_018658.1 LexA regulated protein 3714079 13702029 O3K_18210 Escherichia coli O104:H4 str. 2011C-3493 LexA regulated protein YP_006780316.1 3713786 D 1133852 CDS YP_006780317.1 407483168 13702030 3714219..3714749 1 NC_018658.1 COG0716 Flavodoxins; flavodoxin FldA 3714749 13702030 O3K_18215 Escherichia coli O104:H4 str. 2011C-3493 flavodoxin FldA YP_006780317.1 3714219 D 1133852 CDS YP_006780318.1 407483169 13702031 3714959..3715045 1 NC_018658.1 ryhB-regulated fur leader peptide 3715045 13702031 O3K_18220 Escherichia coli O104:H4 str. 2011C-3493 ryhB-regulated fur leader peptide YP_006780318.1 3714959 D 1133852 CDS YP_006780319.1 407483170 13702032 3715038..3715484 1 NC_018658.1 COG0735 Fe2+/Zn2+ uptake regulation proteins; ferric uptake regulator 3715484 fur 13702032 fur Escherichia coli O104:H4 str. 2011C-3493 ferric uptake regulator YP_006780319.1 3715038 D 1133852 CDS YP_006780320.1 407483171 13702033 complement(3715568..3715894) 1 NC_018658.1 COG0760 Parvulin-like peptidyl-prolyl isomerase; hypothetical protein 3715894 13702033 O3K_18230 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780320.1 3715568 R 1133852 CDS YP_006780321.1 407483172 13702034 complement(3715944..3717350) 1 NC_018658.1 putative outer membrane porin 3717350 13702034 O3K_18235 Escherichia coli O104:H4 str. 2011C-3493 putative outer membrane porin YP_006780321.1 3715944 R 1133852 CDS YP_006780322.1 407483173 13702035 complement(3717796..3719460) 1 NC_018658.1 COG0008 Glutamyl- and glutaminyl-tRNA synthetases; glutaminyl-tRNA synthetase 3719460 13702035 O3K_18240 Escherichia coli O104:H4 str. 2011C-3493 glutaminyl-tRNA synthetase YP_006780322.1 3717796 R 1133852 CDS YP_006780323.1 407483174 13702036 complement(3719663..3721609) 1 NC_018658.1 COG1263 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific; PTS system N-acetyl glucosamine specific transporter subunit IIABC 3721609 13702036 O3K_18245 Escherichia coli O104:H4 str. 2011C-3493 PTS system N-acetyl glucosamine specific transporter subunit IIABC YP_006780323.1 3719663 R 1133852 CDS YP_006780324.1 407483175 13702037 3721942..3722742 1 NC_018658.1 COG0363 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase; glucosamine-6-phosphate deaminase 3722742 nagB 13702037 nagB Escherichia coli O104:H4 str. 2011C-3493 glucosamine-6-phosphate deaminase YP_006780324.1 3721942 D 1133852 CDS YP_006780325.1 407483176 13702038 3722802..3723950 1 NC_018658.1 COG1820 N-acetylglucosamine-6-phosphate deacetylase; N-acetylglucosamine-6-phosphate deacetylase 3723950 nagA 13702038 nagA Escherichia coli O104:H4 str. 2011C-3493 N-acetylglucosamine-6-phosphate deacetylase YP_006780325.1 3722802 D 1133852 CDS YP_006780326.1 407483177 13702039 3723959..3725179 1 NC_018658.1 COG1940 Transcriptional regulator/sugar kinase; N-acetylglucosamine repressor 3725179 13702039 O3K_18260 Escherichia coli O104:H4 str. 2011C-3493 N-acetylglucosamine repressor YP_006780326.1 3723959 D 1133852 CDS YP_006780327.1 407483178 13702040 3725227..3725979 1 NC_018658.1 COG0647 Predicted sugar phosphatases of the HAD superfamily; UMP phosphatase 3725979 13702040 O3K_18265 Escherichia coli O104:H4 str. 2011C-3493 UMP phosphatase YP_006780327.1 3725227 D 1133852 CDS YP_006780328.1 407483179 13702041 3726236..3727900 1 NC_018658.1 COG0367 Asparagine synthase (glutamine-hydrolyzing); asparagine synthetase B 3727900 asnB 13702041 asnB Escherichia coli O104:H4 str. 2011C-3493 asparagine synthetase B YP_006780328.1 3726236 D 1133852 CDS YP_006780329.1 407483180 13702049 complement(3729138..3730313) 1 NC_018658.1 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases; 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase 3730313 ubiF 13702049 ubiF Escherichia coli O104:H4 str. 2011C-3493 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase YP_006780329.1 3729138 R 1133852 CDS YP_006780330.1 407483181 13702050 3730459..3731883 1 NC_018658.1 COG0621 2-methylthioadenine synthetase; (dimethylallyl)adenosine tRNA methylthiotransferase 3731883 13702050 O3K_18280 Escherichia coli O104:H4 str. 2011C-3493 (dimethylallyl)adenosine tRNA methylthiotransferase YP_006780330.1 3730459 D 1133852 CDS YP_006780331.1 407483182 13702051 3731997..3733076 1 NC_018658.1 COG1702 Phosphate starvation-inducible protein PhoH, predicted ATPase; PhoH family protein 3733076 13702051 O3K_18285 Escherichia coli O104:H4 str. 2011C-3493 PhoH family protein YP_006780331.1 3731997 D 1133852 CDS YP_006780332.1 407483183 13702052 3733073..3733540 1 NC_018658.1 COG0319 Predicted metal-dependent hydrolase; metal-binding heat shock protein 3733540 13702052 O3K_18290 Escherichia coli O104:H4 str. 2011C-3493 metal-binding heat shock protein YP_006780332.1 3733073 D 1133852 CDS YP_006780333.1 407483184 13702053 3733630..3734508 1 NC_018658.1 COG4535 Putative Mg2+ and Co2+ transporter CorC; magnesium/cobalt efflux protein CorC 3734508 13702053 O3K_18295 Escherichia coli O104:H4 str. 2011C-3493 magnesium/cobalt efflux protein CorC YP_006780333.1 3733630 D 1133852 CDS YP_006780334.1 407483185 13702054 3734533..3736071 1 NC_018658.1 COG0815 Apolipoprotein N-acyltransferase; apolipoprotein N-acyltransferase 3736071 lnt 13702054 lnt Escherichia coli O104:H4 str. 2011C-3493 apolipoprotein N-acyltransferase YP_006780334.1 3734533 D 1133852 CDS YP_006780335.1 407483186 13702055 3738480..3739388 1 NC_018658.1 COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; glutamate and aspartate transporter subunit 3739388 13702055 O3K_18315 Escherichia coli O104:H4 str. 2011C-3493 glutamate and aspartate transporter subunit YP_006780335.1 3738480 D 1133852 CDS YP_006780336.1 407483187 13702056 3739558..3740298 1 NC_018658.1 COG0765 ABC-type amino acid transport system, permease component; glutamate/aspartate transport system permease GltJ 3740298 13702056 O3K_18320 Escherichia coli O104:H4 str. 2011C-3493 glutamate/aspartate transport system permease GltJ YP_006780336.1 3739558 D 1133852 CDS YP_006780337.1 407483188 13702057 3740298..3740972 1 NC_018658.1 COG0765 ABC-type amino acid transport system, permease component; glutamate/aspartate transport system permease GltK 3740972 13702057 O3K_18325 Escherichia coli O104:H4 str. 2011C-3493 glutamate/aspartate transport system permease GltK YP_006780337.1 3740298 D 1133852 CDS YP_006780338.1 407483189 13702058 3740972..3741697 1 NC_018658.1 COG1126 ABC-type polar amino acid transport system, ATPase component; glutamate/aspartate transport ATP-binding protein gltL 3741697 13702058 O3K_18330 Escherichia coli O104:H4 str. 2011C-3493 glutamate/aspartate transport ATP-binding protein gltL YP_006780338.1 3740972 D 1133852 CDS YP_006780339.1 407483190 13702059 3741815..3742750 1 NC_018658.1 COG1957 Inosine-uridine nucleoside N-ribohydrolase; ribonucleoside hydrolase 1 3742750 rihA 13702059 rihA Escherichia coli O104:H4 str. 2011C-3493 ribonucleoside hydrolase 1 YP_006780339.1 3741815 D 1133852 CDS YP_006780340.1 407483191 13702060 3742834..3744504 1 NC_018658.1 COG0443 Molecular chaperone; molecular chaperone DnaK 3744504 13702060 O3K_18340 Escherichia coli O104:H4 str. 2011C-3493 molecular chaperone DnaK YP_006780340.1 3742834 D 1133852 CDS YP_006780341.1 407483192 13702061 complement(3744564..3746015) 1 NC_018658.1 Hsc56 co-chaperone of HscC 3746015 13702061 O3K_18345 Escherichia coli O104:H4 str. 2011C-3493 Hsc56 co-chaperone of HscC YP_006780341.1 3744564 R 1133852 CDS YP_006780342.1 407483193 13702062 complement(3746012..3746719) 1 NC_018658.1 hypothetical protein 3746719 13702062 O3K_18350 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780342.1 3746012 R 1133852 CDS YP_006780343.1 407483194 13702063 3746820..3747374 1 NC_018658.1 COG0790 FOG: TPR repeat, SEL1 subfamily; hypothetical protein 3747374 13702063 O3K_18355 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780343.1 3746820 D 1133852 CDS YP_006780344.1 407483195 13702064 complement(3747384..3748811) 1 NC_018658.1 COG2214 DnaJ-class molecular chaperone; DnaJ-class chaperone 3748811 13702064 O3K_18360 Escherichia coli O104:H4 str. 2011C-3493 DnaJ-class chaperone YP_006780344.1 3747384 R 1133852 CDS YP_006780345.1 407483196 13702065 complement(3748808..3749515) 1 NC_018658.1 hypothetical protein 3749515 13702065 O3K_18365 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780345.1 3748808 R 1133852 CDS YP_006780346.1 407483197 13702066 3749679..3750656 1 NC_018658.1 COG0790 FOG: TPR repeat, SEL1 subfamily; hypothetical protein 3750656 13702066 O3K_18370 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780346.1 3749679 D 1133852 CDS YP_006780347.1 407483198 13702067 complement(3750726..3751208) 1 NC_018658.1 COG0542 ATPases with chaperone activity, ATP-binding subunit; hypothetical protein 3751208 13702067 O3K_18375 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780347.1 3750726 R 1133852 CDS YP_006780348.1 407483199 13702068 3751443..3754025 1 NC_018658.1 COG0495 Leucyl-tRNA synthetase; leucyl-tRNA synthetase 3754025 leuS 13702068 leuS Escherichia coli O104:H4 str. 2011C-3493 leucyl-tRNA synthetase YP_006780348.1 3751443 D 1133852 CDS YP_006780349.1 407483200 13702069 3754040..3754621 1 NC_018658.1 COG2980 Rare lipoprotein B; LPS-assembly lipoprotein RlpB 3754621 13702069 O3K_18385 Escherichia coli O104:H4 str. 2011C-3493 LPS-assembly lipoprotein RlpB YP_006780349.1 3754040 D 1133852 CDS YP_006780350.1 407483201 13702070 3754621..3755652 1 NC_018658.1 COG1466 DNA polymerase III, delta subunit; DNA polymerase III subunit delta 3755652 holA 13702070 holA Escherichia coli O104:H4 str. 2011C-3493 DNA polymerase III subunit delta YP_006780350.1 3754621 D 1133852 CDS YP_006780351.1 407483202 13702071 3755654..3756295 1 NC_018658.1 COG1057 Nicotinic acid mononucleotide adenylyltransferase; nicotinic acid mononucleotide adenylyltransferase 3756295 nadD 13702071 nadD Escherichia coli O104:H4 str. 2011C-3493 nicotinic acid mononucleotide adenylyltransferase YP_006780351.1 3755654 D 1133852 CDS YP_006780352.1 407483203 13702072 3756319..3756930 1 NC_018658.1 COG0406 Fructose-2,6-bisphosphatase; alpha-ribazole phosphatase 3756930 13702072 O3K_18400 Escherichia coli O104:H4 str. 2011C-3493 alpha-ribazole phosphatase YP_006780352.1 3756319 D 1133852 CDS YP_006780353.1 407483204 13702073 3757190..3757507 1 NC_018658.1 COG0799 Uncharacterized homolog of plant Iojap protein; ribosome-associated protein 3757507 13702073 O3K_18405 Escherichia coli O104:H4 str. 2011C-3493 ribosome-associated protein YP_006780353.1 3757190 D 1133852 CDS YP_006780354.1 407483205 13702074 3757511..3757978 1 NC_018658.1 COG1576 Uncharacterized conserved protein; rRNA large subunit methyltransferase 3757978 13702074 O3K_18410 Escherichia coli O104:H4 str. 2011C-3493 rRNA large subunit methyltransferase YP_006780354.1 3757511 D 1133852 CDS YP_006780355.1 407483206 13702075 3758009..3759910 1 NC_018658.1 COG0768 Cell division protein FtsI/penicillin-binding protein 2; penicillin-binding protein 2 3759910 13702075 O3K_18415 Escherichia coli O104:H4 str. 2011C-3493 penicillin-binding protein 2 YP_006780355.1 3758009 D 1133852 CDS YP_006780356.1 407483207 13702076 3759913..3761025 1 NC_018658.1 COG0772 Bacterial cell division membrane protein; cell wall shape-determining protein 3761025 13702076 O3K_18420 Escherichia coli O104:H4 str. 2011C-3493 cell wall shape-determining protein YP_006780356.1 3759913 D 1133852 CDS YP_006780357.1 407483208 13702077 3761036..3762124 1 NC_018658.1 COG0797 Lipoproteins; rare lipoprotein A 3762124 13702077 O3K_18425 Escherichia coli O104:H4 str. 2011C-3493 rare lipoprotein A YP_006780357.1 3761036 D 1133852 CDS YP_006780358.1 407483209 13702078 3762263..3763474 1 NC_018658.1 COG1686 D-alanyl-D-alanine carboxypeptidase; D-alanyl-D-alanine carboxypeptidase 3763474 13702078 O3K_18430 Escherichia coli O104:H4 str. 2011C-3493 D-alanyl-D-alanine carboxypeptidase YP_006780358.1 3762263 D 1133852 CDS YP_006780359.1 407483210 13702079 3763585..3763848 1 NC_018658.1 COG2921 Uncharacterized conserved protein; hypothetical protein 3763848 13702079 O3K_18435 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780359.1 3763585 D 1133852 CDS YP_006780360.1 407483211 13702080 3763949..3764590 1 NC_018658.1 COG0321 Lipoate-protein ligase B; lipoate-protein ligase B 3764590 13702080 O3K_18440 Escherichia coli O104:H4 str. 2011C-3493 lipoate-protein ligase B YP_006780360.1 3763949 D 1133852 CDS YP_006780361.1 407483212 13702081 complement(3764642..3764791) 1 NC_018658.1 COG0474 Cation transport ATPase; hypothetical protein 3764791 13702081 O3K_18445 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780361.1 3764642 R 1133852 CDS YP_006780362.1 407483213 13702082 3764849..3765802 1 NC_018658.1 COG0583 Transcriptional regulator; putative DNA-binding transcriptional regulator 3765802 13702082 O3K_18450 Escherichia coli O104:H4 str. 2011C-3493 putative DNA-binding transcriptional regulator YP_006780362.1 3764849 D 1133852 CDS YP_006780363.1 407483214 13702083 3766011..3766976 1 NC_018658.1 COG0320 Lipoate synthase; lipoyl synthase 3766976 13702083 O3K_18455 Escherichia coli O104:H4 str. 2011C-3493 lipoyl synthase YP_006780363.1 3766011 D 1133852 CDS YP_006780364.1 407483215 13702084 complement(3767077..3767280) 1 NC_018658.1 COG1826 Sec-independent protein secretion pathway components; twin arginine translocase protein E 3767280 tatE 13702084 tatE Escherichia coli O104:H4 str. 2011C-3493 twin arginine translocase protein E YP_006780364.1 3767077 R 1133852 CDS YP_006780365.1 407483216 13702085 complement(3767409..3768197) 1 NC_018658.1 COG0388 Predicted amidohydrolase; hypothetical protein 3768197 13702085 O3K_18465 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780365.1 3767409 R 1133852 CDS YP_006780366.1 407483217 13702086 3768290..3768673 1 NC_018658.1 COG0239 Integral membrane protein possibly involved in chromosome condensation; chromosome condensation membrane protein 3768673 13702086 O3K_18470 Escherichia coli O104:H4 str. 2011C-3493 chromosome condensation membrane protein YP_006780366.1 3768290 D 1133852 CDS YP_006780367.1 407483218 13702087 complement(3768727..3768936) 1 NC_018658.1 COG1278 Cold shock proteins; cold shock protein CspE 3768936 cspE 13702087 cspE Escherichia coli O104:H4 str. 2011C-3493 cold shock protein CspE YP_006780367.1 3768727 R 1133852 CDS YP_006780368.1 407483219 13702088 complement(3769111..3769671) 1 NC_018658.1 phospholipid:lipid A palmitoyltransferase 3769671 pagP 13702088 pagP Escherichia coli O104:H4 str. 2011C-3493 phospholipid:lipid A palmitoyltransferase YP_006780368.1 3769111 R 1133852 CDS YP_006780369.1 407483220 13702089 3770260..3771645 1 NC_018658.1 COG3069 C4-dicarboxylate transporter; C4-dicarboxylate transporter DcuC 3771645 dcuC 13702089 dcuC Escherichia coli O104:H4 str. 2011C-3493 C4-dicarboxylate transporter DcuC YP_006780369.1 3770260 D 1133852 CDS YP_006780370.1 407483221 13702169 complement(3771686..3772366) 1 NC_018658.1 COG4565 Response regulator of citrate/malate metabolism; two-component response regulator DpiA 3772366 dpiA 13702169 dpiA Escherichia coli O104:H4 str. 2011C-3493 two-component response regulator DpiA YP_006780370.1 3771686 R 1133852 CDS YP_006780371.1 407483222 13702170 complement(3772335..3773993) 1 NC_018658.1 COG3290 Signal transduction histidine kinase regulating citrate/malate metabolism; sensor histidine kinase DpiB 3773993 dpiB 13702170 dpiB Escherichia coli O104:H4 str. 2011C-3493 sensor histidine kinase DpiB YP_006780371.1 3772335 R 1133852 CDS YP_006780372.1 407483223 13702171 3774373..3775431 1 NC_018658.1 COG3053 Citrate lyase synthetase; citrate lyase synthetase 3775431 13702171 O3K_18500 Escherichia coli O104:H4 str. 2011C-3493 citrate lyase synthetase YP_006780372.1 3774373 D 1133852 CDS YP_006780373.1 407483224 13702172 3775446..3775742 1 NC_018658.1 COG3052 Citrate lyase, gamma subunit; citrate lyase subunit gamma 3775742 13702172 O3K_18505 Escherichia coli O104:H4 str. 2011C-3493 citrate lyase subunit gamma YP_006780373.1 3775446 D 1133852 CDS YP_006780374.1 407483225 13702173 3775739..3776647 1 NC_018658.1 COG2301 Citrate lyase beta subunit; citrate lyase subunit beta 3776647 13702173 O3K_18510 Escherichia coli O104:H4 str. 2011C-3493 citrate lyase subunit beta YP_006780374.1 3775739 D 1133852 CDS YP_006780375.1 407483226 13702174 3776658..3778190 1 NC_018658.1 COG3051 Citrate lyase, alpha subunit; citrate lyase subunit alpha 3778190 13702174 O3K_18515 Escherichia coli O104:H4 str. 2011C-3493 citrate lyase subunit alpha YP_006780375.1 3776658 D 1133852 CDS YP_006780376.1 407483227 13702175 3778194..3778745 1 NC_018658.1 COG3697 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase); 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase 3778745 citX 13702175 citX Escherichia coli O104:H4 str. 2011C-3493 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase YP_006780376.1 3778194 D 1133852 CDS YP_006780377.1 407483228 13702176 3778720..3779598 1 NC_018658.1 COG1767 Triphosphoribosyl-dephospho-CoA synthetase; triphosphoribosyl-dephospho-CoA synthase 3779598 citG 13702176 citG Escherichia coli O104:H4 str. 2011C-3493 triphosphoribosyl-dephospho-CoA synthase YP_006780377.1 3778720 D 1133852 CDS YP_006780378.1 407483229 13702177 3779649..3781112 1 NC_018658.1 COG0471 Di- and tricarboxylate transporters; citrate/succinate antiporter CitT 3781112 13702177 O3K_18530 Escherichia coli O104:H4 str. 2011C-3493 citrate/succinate antiporter CitT YP_006780378.1 3779649 D 1133852 CDS YP_006780379.1 407483230 13702178 3781226..3782032 1 NC_018658.1 COG3719 Ribonuclease I; ribonuclease I 3782032 13702178 O3K_18535 Escherichia coli O104:H4 str. 2011C-3493 ribonuclease I YP_006780379.1 3781226 D 1133852 CDS YP_006780380.1 407483231 13702179 3782262..3782672 1 NC_018658.1 COG0782 Transcription elongation factor; nucleoside diphosphate kinase regulator 3782672 13702179 O3K_18540 Escherichia coli O104:H4 str. 2011C-3493 nucleoside diphosphate kinase regulator YP_006780380.1 3782262 D 1133852 CDS YP_006780381.1 407483232 13702180 complement(3782903..3784141) 1 NC_018658.1 COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases; oxidoreductase zinc-binding dehydrogenase family protein 3784141 13702180 O3K_18545 Escherichia coli O104:H4 str. 2011C-3493 oxidoreductase zinc-binding dehydrogenase family protein YP_006780381.1 3782903 R 1133852 CDS YP_006780382.1 407483233 13702181 3784362..3784790 1 NC_018658.1 COG0589 Universal stress protein UspA and related nucleotide-binding proteins; universal stress protein UspG 3784790 13702181 O3K_18550 Escherichia coli O104:H4 str. 2011C-3493 universal stress protein UspG YP_006780382.1 3784362 D 1133852 CDS YP_006780383.1 407483234 13702182 complement(3784911..3786476) 1 NC_018658.1 COG3634 Alkyl hydroperoxide reductase, large subunit; alkyl hydroperoxide reductase subunit F 3786476 13702182 O3K_18555 Escherichia coli O104:H4 str. 2011C-3493 alkyl hydroperoxide reductase subunit F YP_006780383.1 3784911 R 1133852 CDS YP_006780384.1 407483235 13702183 complement(3786605..3787168) 1 NC_018658.1 COG0450 Peroxiredoxin; alkyl hydroperoxide reductase subunit C 3787168 13702183 O3K_18560 Escherichia coli O104:H4 str. 2011C-3493 alkyl hydroperoxide reductase subunit C YP_006780384.1 3786605 R 1133852 CDS YP_006780385.1 407483236 13702184 3787540..3788286 1 NC_018658.1 COG1651 Protein-disulfide isomerase; disulfide isomerase/thiol-disulfide oxidase 3788286 dsbG 13702184 dsbG Escherichia coli O104:H4 str. 2011C-3493 disulfide isomerase/thiol-disulfide oxidase YP_006780385.1 3787540 D 1133852 CDS YP_006780386.1 407483237 13702185 3788495..3789397 1 NC_018658.1 COG0583 Transcriptional regulator; LysR family transcriptional regulator 3789397 13702185 O3K_18570 Escherichia coli O104:H4 str. 2011C-3493 LysR family transcriptional regulator YP_006780386.1 3788495 D 1133852 CDS YP_006780387.1 407483238 13702186 3789544..3790764 1 NC_018658.1 COG3969 Predicted phosphoadenosine phosphosulfate sulfotransferase; phosphoadenosine phosphosulfate reductase family protein 3790764 13702186 O3K_18575 Escherichia coli O104:H4 str. 2011C-3493 phosphoadenosine phosphosulfate reductase family protein YP_006780387.1 3789544 D 1133852 CDS YP_006780388.1 407483239 13702187 3790749..3791366 1 NC_018658.1 COG1475 Predicted transcriptional regulators; Immunoglobulin-binding regulator family protein 3791366 13702187 O3K_18580 Escherichia coli O104:H4 str. 2011C-3493 Immunoglobulin-binding regulator family protein YP_006780388.1 3790749 D 1133852 CDS YP_006780389.1 407483240 13702188 complement(3791367..3792527) 1 NC_018658.1 COG0436 Aspartate/tyrosine/aromatic aminotransferase; methionine aminotransferase 3792527 13702188 O3K_18585 Escherichia coli O104:H4 str. 2011C-3493 methionine aminotransferase YP_006780389.1 3791367 R 1133852 CDS YP_006780390.1 407483241 13702189 3792636..3793724 1 NC_018658.1 COG0371 Glycerol dehydrogenase and related enzymes; oxidoreductase 3793724 13702189 O3K_18590 Escherichia coli O104:H4 str. 2011C-3493 oxidoreductase YP_006780390.1 3792636 D 1133852 CDS YP_006780391.1 407483242 13702190 complement(3793734..3793931) 1 NC_018658.1 COG2879 Uncharacterized small protein; hypothetical protein 3793931 13702190 O3K_18595 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780391.1 3793734 R 1133852 CDS YP_006780392.1 407483243 13702191 complement(3794113..3796218) 1 NC_018658.1 COG1966 Carbon starvation protein, predicted membrane protein; carbon starvation protein A 3796218 13702191 O3K_18600 Escherichia coli O104:H4 str. 2011C-3493 carbon starvation protein A YP_006780392.1 3794113 R 1133852 CDS YP_006780393.1 407483244 13702192 complement(3796399..3796812) 1 NC_018658.1 COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism; thioesterase 3796812 13702192 O3K_18605 Escherichia coli O104:H4 str. 2011C-3493 thioesterase YP_006780393.1 3796399 R 1133852 CDS YP_006780394.1 407483245 13702193 complement(3796815..3797561) 1 NC_018658.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); 2,3-dihydroxybenzoate-2,3-dehydrogenase 3797561 13702193 O3K_18610 Escherichia coli O104:H4 str. 2011C-3493 2,3-dihydroxybenzoate-2,3-dehydrogenase YP_006780394.1 3796815 R 1133852 CDS YP_006780395.1 407483246 13702194 complement(3797561..3798418) 1 NC_018658.1 COG1535 Isochorismate hydrolase; isochorismatase 3798418 13702194 O3K_18615 Escherichia coli O104:H4 str. 2011C-3493 isochorismatase YP_006780395.1 3797561 R 1133852 CDS YP_006780396.1 407483247 13702195 complement(3798432..3800042) 1 NC_018658.1 COG1021 Peptide arylation enzymes; enterobactin synthase subunit E 3800042 entE 13702195 entE Escherichia coli O104:H4 str. 2011C-3493 enterobactin synthase subunit E YP_006780396.1 3798432 R 1133852 CDS YP_006780397.1 407483248 13702196 complement(3800052..3801227) 1 NC_018658.1 COG1169 Isochorismate synthase; isochorismate synthase EntC 3801227 13702196 O3K_18625 Escherichia coli O104:H4 str. 2011C-3493 isochorismate synthase EntC YP_006780397.1 3800052 R 1133852 CDS YP_006780398.1 407483249 13702197 3801602..3802558 1 NC_018658.1 COG4592 ABC-type Fe2+-enterobactin transport system, periplasmic component; iron-enterobactin transporter periplasmic binding protein 3802558 13702197 O3K_18630 Escherichia coli O104:H4 str. 2011C-3493 iron-enterobactin transporter periplasmic binding protein YP_006780398.1 3801602 D 1133852 CDS YP_006780399.1 407483250 13702198 complement(3802562..3803812) 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; enterobactin exporter EntS 3803812 13702198 O3K_18635 Escherichia coli O104:H4 str. 2011C-3493 enterobactin exporter EntS YP_006780399.1 3802562 R 1133852 CDS YP_006780400.1 407483251 13702199 3803923..3804927 1 NC_018658.1 COG0609 ABC-type Fe3+-siderophore transport system, permease component; iron-enterobactin transporter membrane protein 3804927 13702199 O3K_18640 Escherichia coli O104:H4 str. 2011C-3493 iron-enterobactin transporter membrane protein YP_006780400.1 3803923 D 1133852 CDS YP_006780401.1 407483252 13702200 3804924..3805916 1 NC_018658.1 COG4779 ABC-type enterobactin transport system, permease component; iron-enterobactin transporter permease 3805916 13702200 O3K_18645 Escherichia coli O104:H4 str. 2011C-3493 iron-enterobactin transporter permease YP_006780401.1 3804924 D 1133852 CDS YP_006780402.1 407483253 13702201 3805913..3806728 1 NC_018658.1 COG1120 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components; iron-enterobactin transporter ATP-binding protein 3806728 13702201 O3K_18650 Escherichia coli O104:H4 str. 2011C-3493 iron-enterobactin transporter ATP-binding protein YP_006780402.1 3805913 D 1133852 CDS YP_006780403.1 407483254 13702202 complement(3806725..3807858) 1 NC_018658.1 COG3765 Chain length determinant protein; LPS O-antigen length regulator 3807858 13702202 O3K_18655 Escherichia coli O104:H4 str. 2011C-3493 LPS O-antigen length regulator YP_006780403.1 3806725 R 1133852 CDS YP_006780404.1 407483255 13702203 complement(3808074..3811955) 1 NC_018658.1 COG1020 Non-ribosomal peptide synthetase modules and related proteins; enterobactin synthase subunit F 3811955 entF 13702203 entF Escherichia coli O104:H4 str. 2011C-3493 enterobactin synthase subunit F YP_006780404.1 3808074 R 1133852 CDS YP_006780405.1 407483256 13702204 complement(3811952..3812170) 1 NC_018658.1 COG3251 Uncharacterized protein conserved in bacteria; hypothetical protein 3812170 13702204 O3K_18665 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780405.1 3811952 R 1133852 CDS YP_006780406.1 407483257 13702205 complement(3812173..3813297) 1 NC_018658.1 COG2382 Enterochelin esterase and related enzymes; enterobactin/ferric enterobactin esterase 3813297 13702205 O3K_18670 Escherichia coli O104:H4 str. 2011C-3493 enterobactin/ferric enterobactin esterase YP_006780406.1 3812173 R 1133852 CDS YP_006780407.1 407483258 13702206 3813618..3815858 1 NC_018658.1 COG4771 Outer membrane receptor for ferrienterochelin and colicins; outer membrane receptor FepA 3815858 13702206 O3K_18675 Escherichia coli O104:H4 str. 2011C-3493 outer membrane receptor FepA YP_006780407.1 3813618 D 1133852 CDS YP_006780408.1 407483259 13702207 3816024..3816653 1 NC_018658.1 COG2977 Phosphopantetheinyl transferase component of siderophore synthetase; enterobactin synthase multienzyme complex phosphopantetheinyltransferase 3816653 13702207 O3K_18680 Escherichia coli O104:H4 str. 2011C-3493 enterobactin synthase multienzyme complex phosphopantetheinyltransferase YP_006780408.1 3816024 D 1133852 CDS YP_006780409.1 407483260 13702208 3816819..3818093 1 NC_018658.1 COG3385 FOG: Transposase and inactivated derivatives; IS186, transposase 3818093 13702208 O3K_18685 Escherichia coli O104:H4 str. 2011C-3493 IS186, transposase YP_006780409.1 3816819 D 1133852 CDS YP_006780410.1 407483261 13702209 complement(3818123..3818275) 1 NC_018658.1 regulatory peptide MokC 3818275 13702209 O3K_18690 Escherichia coli O104:H4 str. 2011C-3493 regulatory peptide MokC YP_006780410.1 3818123 R 1133852 CDS YP_006780411.1 407483262 13702210 complement(3818786..3819898) 1 NC_018658.1 COG3385 FOG: Transposase and inactivated derivatives; putative transposase insL for insertion sequence IS186 3819898 13702210 O3K_18695 Escherichia coli O104:H4 str. 2011C-3493 putative transposase insL for insertion sequence IS186 YP_006780411.1 3818786 R 1133852 CDS YP_006780412.1 407483263 13702211 complement(3819975..3820127) 1 NC_018658.1 hypothetical protein 3820127 13702211 O3K_18700 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780412.1 3819975 R 1133852 CDS YP_006780413.1 407483264 13702212 complement(3820393..3820494) 1 NC_018658.1 hypothetical protein 3820494 13702212 O3K_18705 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780413.1 3820393 R 1133852 CDS YP_006780414.1 407483265 13702213 3820569..3821687 1 NC_018658.1 COG2170 Uncharacterized conserved protein; gamma-glutamyl:cysteine ligase 3821687 13702213 O3K_18710 Escherichia coli O104:H4 str. 2011C-3493 gamma-glutamyl:cysteine ligase YP_006780414.1 3820569 D 1133852 CDS YP_006780415.1 407483266 13702214 3821753..3822001 1 NC_018658.1 inner membrane protein 3822001 13702214 O3K_18715 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006780415.1 3821753 D 1133852 CDS YP_006780416.1 407483267 13702215 3822066..3822434 1 NC_018658.1 COG2315 Uncharacterized protein conserved in bacteria; hypothetical protein 3822434 13702215 O3K_18720 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780416.1 3822066 D 1133852 CDS YP_006780417.1 407483268 13702216 3822528..3823181 1 NC_018658.1 COG0778 Nitroreductase; dihydropteridine reductase 3823181 13702216 O3K_18725 Escherichia coli O104:H4 str. 2011C-3493 dihydropteridine reductase YP_006780417.1 3822528 D 1133852 CDS YP_006780418.1 407483269 13702217 3823289..3824536 1 NC_018658.1 COG0668 Small-conductance mechanosensitive channel; putative mechanosensitive channel 3824536 13702217 O3K_18730 Escherichia coli O104:H4 str. 2011C-3493 putative mechanosensitive channel YP_006780418.1 3823289 D 1133852 CDS YP_006780419.1 407483270 13702218 complement(3824604..3825980) 1 NC_018658.1 COG1113 Gamma-aminobutyrate permease and related permeases; phenylalanine transporter 3825980 13702218 O3K_18735 Escherichia coli O104:H4 str. 2011C-3493 phenylalanine transporter YP_006780419.1 3824604 R 1133852 CDS YP_006780420.1 407483271 13702219 complement(3826082..3829225) 1 NC_018658.1 COG3696 Putative silver efflux pump; copper/silver efflux system, membrane component 3829225 13702219 O3K_18740 Escherichia coli O104:H4 str. 2011C-3493 copper/silver efflux system, membrane component YP_006780420.1 3826082 R 1133852 CDS YP_006780421.1 407483272 13702220 complement(3829237..3830460) 1 NC_018658.1 COG0845 Membrane-fusion protein; copper/silver efflux system membrane fusion protein CusB 3830460 13702220 O3K_18745 Escherichia coli O104:H4 str. 2011C-3493 copper/silver efflux system membrane fusion protein CusB YP_006780421.1 3829237 R 1133852 CDS YP_006780422.1 407483273 13702221 complement(3830476..3830808) 1 NC_018658.1 COG5569 Uncharacterized conserved protein; copper-binding protein 3830808 13702221 O3K_18750 Escherichia coli O104:H4 str. 2011C-3493 copper-binding protein YP_006780422.1 3830476 R 1133852 CDS YP_006780423.1 407483274 13702222 complement(3830832..3832214) 1 NC_018658.1 COG1538 Outer membrane protein; copper/silver efflux system outer membrane protein CusC 3832214 13702222 O3K_18755 Escherichia coli O104:H4 str. 2011C-3493 copper/silver efflux system outer membrane protein CusC YP_006780423.1 3830832 R 1133852 CDS YP_006780424.1 407483275 13702223 3832371..3833054 1 NC_018658.1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; DNA-binding transcriptional activator CusR 3833054 13702223 O3K_18760 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional activator CusR YP_006780424.1 3832371 D 1133852 CDS YP_006780425.1 407483276 13702224 3833044..3834492 1 NC_018658.1 COG0642 Signal transduction histidine kinase; sensor kinase CusS 3834492 13702224 O3K_18765 Escherichia coli O104:H4 str. 2011C-3493 sensor kinase CusS YP_006780425.1 3833044 D 1133852 CDS YP_006780426.1 407483277 13702225 3835229..3837130 1 NC_018658.1 COG3501 Uncharacterized protein conserved in bacteria; Rhs element Vgr protein 3837130 13702225 O3K_18770 Escherichia coli O104:H4 str. 2011C-3493 Rhs element Vgr protein YP_006780426.1 3835229 D 1133852 CDS YP_006780427.1 407483278 13702226 3837158..3837619 1 NC_018658.1 COG5435 Uncharacterized conserved protein; hypothetical protein 3837619 13702226 O3K_18775 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780427.1 3837158 D 1133852 CDS YP_006780428.1 407483279 13702227 3841167..3842501 1 NC_018658.1 COG3209 Rhs family protein; Rhs core protein with extension 3842501 13702227 O3K_18780 Escherichia coli O104:H4 str. 2011C-3493 Rhs core protein with extension YP_006780428.1 3841167 D 1133852 CDS YP_006780429.1 407483280 13702228 3842498..3842749 1 NC_018658.1 hypothetical protein 3842749 13702228 O3K_18785 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780429.1 3842498 D 1133852 CDS YP_006780430.1 407483281 13702229 3842864..3843175 1 NC_018658.1 hypothetical protein 3843175 13702229 O3K_18790 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780430.1 3842864 D 1133852 CDS YP_006780431.1 407483282 13702230 3843279..3844415 1 NC_018658.1 COG5433 Transposase; transposase 3844415 13702230 O3K_18795 Escherichia coli O104:H4 str. 2011C-3493 transposase YP_006780431.1 3843279 D 1133852 CDS YP_006780432.1 407483283 13702231 3844684..3846921 1 NC_018658.1 COG1215 Glycosyltransferases, probably involved in cell wall biogenesis; bacteriophage N4 adsorption protein B 3846921 nfrB 13702231 nfrB Escherichia coli O104:H4 str. 2011C-3493 bacteriophage N4 adsorption protein B YP_006780432.1 3844684 D 1133852 CDS YP_006780433.1 407483284 13702232 3846908..3849880 1 NC_018658.1 COG0457 FOG: TPR repeat; bacteriophage N4 receptor, outer membrane subunit 3849880 13702232 O3K_18805 Escherichia coli O104:H4 str. 2011C-3493 bacteriophage N4 receptor, outer membrane subunit YP_006780433.1 3846908 D 1133852 CDS YP_006780434.1 407483285 13702233 3849881..3850771 1 NC_018658.1 hypothetical protein 3850771 13702233 O3K_18810 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780434.1 3849881 D 1133852 CDS YP_006780435.1 407483286 13702234 3850954..3851715 1 NC_018658.1 COG2207 AraC-type DNA-binding domain-containing proteins; DNA-binding transcriptional activator EnvY 3851715 13702234 O3K_18815 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional activator EnvY YP_006780435.1 3850954 D 1133852 CDS YP_006780436.1 407483287 13702236 3852080..3852712 1 NC_018658.1 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; transcriptional regulator FimZ 3852712 13702236 O3K_18825 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator FimZ YP_006780436.1 3852080 D 1133852 CDS YP_006780437.1 407483288 13702237 complement(3852715..3853230) 1 NC_018658.1 COG3539 P pilus assembly protein, pilin FimA; fimbrial-like adhesin protein SfmF 3853230 13702237 O3K_18830 Escherichia coli O104:H4 str. 2011C-3493 fimbrial-like adhesin protein SfmF YP_006780437.1 3852715 R 1133852 CDS YP_006780438.1 407483289 13702238 complement(3853241..3854248) 1 NC_018658.1 fimbrial-like adhesin 3854248 fimH 13702238 fimH Escherichia coli O104:H4 str. 2011C-3493 fimbrial-like adhesin YP_006780438.1 3853241 R 1133852 CDS YP_006780439.1 407483290 13702307 complement(3854261..3856870) 1 NC_018658.1 COG3188 P pilus assembly protein, porin PapC; outer membrane usher protein FimD 3856870 13702307 O3K_18840 Escherichia coli O104:H4 str. 2011C-3493 outer membrane usher protein FimD YP_006780439.1 3854261 R 1133852 CDS YP_006780440.1 407483291 13702308 complement(3856901..3857593) 1 NC_018658.1 COG3121 P pilus assembly protein, chaperone PapD; fimbrial chaperone protein FimC 3857593 13702308 O3K_18845 Escherichia coli O104:H4 str. 2011C-3493 fimbrial chaperone protein FimC YP_006780440.1 3856901 R 1133852 CDS YP_006780441.1 407483292 13702309 complement(3857813..3858355) 1 NC_018658.1 COG3539 P pilus assembly protein, pilin FimA; type-1 fimbrial protein subunit A 3858355 13702309 O3K_18850 Escherichia coli O104:H4 str. 2011C-3493 type-1 fimbrial protein subunit A YP_006780441.1 3857813 R 1133852 CDS YP_006780442.1 407483293 13702310 3858836..3859702 1 NC_018658.1 COG0190 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 3859702 13702310 O3K_18855 Escherichia coli O104:H4 str. 2011C-3493 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase YP_006780442.1 3858836 D 1133852 CDS YP_006780443.1 407483294 13702311 3859704..3859916 1 NC_018658.1 COG2501 Uncharacterized conserved protein; hypothetical protein 3859916 13702311 O3K_18860 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780443.1 3859704 D 1133852 CDS YP_006780444.1 407483295 13702312 3860024..3860545 1 NC_018658.1 COG1988 Predicted membrane-bound metal-dependent hydrolases; inner membrane protein YbcI 3860545 13702312 O3K_18865 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YbcI YP_006780444.1 3860024 D 1133852 CDS YP_006780445.1 407483296 13702313 complement(3860581..3861966) 1 NC_018658.1 COG0215 Cysteinyl-tRNA synthetase; cysteinyl-tRNA synthetase 3861966 cysS 13702313 cysS Escherichia coli O104:H4 str. 2011C-3493 cysteinyl-tRNA synthetase YP_006780445.1 3860581 R 1133852 CDS YP_006780446.1 407483297 13702314 3862140..3862634 1 NC_018658.1 COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family; peptidyl-prolyl cis-trans isomerase B 3862634 13702314 O3K_18875 Escherichia coli O104:H4 str. 2011C-3493 peptidyl-prolyl cis-trans isomerase B YP_006780446.1 3862140 D 1133852 CDS YP_006780447.1 407483298 13702315 3862637..3863359 1 NC_018658.1 COG2908 Uncharacterized protein conserved in bacteria; UDP-2,3-diacylglucosamine hydrolase 3863359 13702315 O3K_18880 Escherichia coli O104:H4 str. 2011C-3493 UDP-2,3-diacylglucosamine hydrolase YP_006780447.1 3862637 D 1133852 CDS YP_006780448.1 407483299 13702316 3863477..3863986 1 NC_018658.1 COG0041 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase; phosphoribosylaminoimidazole carboxylase catalytic subunit 3863986 13702316 O3K_18885 Escherichia coli O104:H4 str. 2011C-3493 phosphoribosylaminoimidazole carboxylase catalytic subunit YP_006780448.1 3863477 D 1133852 CDS YP_006780449.1 407483300 13702317 3863983..3865050 1 NC_018658.1 COG0026 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase); phosphoribosylaminoimidazole carboxylase ATPase subunit 3865050 13702317 O3K_18890 Escherichia coli O104:H4 str. 2011C-3493 phosphoribosylaminoimidazole carboxylase ATPase subunit YP_006780449.1 3863983 D 1133852 CDS YP_006780450.1 407483301 13702318 complement(3865245..3866138) 1 NC_018658.1 COG0549 Carbamate kinase; carbamate kinase 3866138 13702318 O3K_18895 Escherichia coli O104:H4 str. 2011C-3493 carbamate kinase YP_006780450.1 3865245 R 1133852 CDS YP_006780451.1 407483302 13702319 complement(3866135..3866950) 1 NC_018658.1 hypothetical protein 3866950 13702319 O3K_18900 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780451.1 3866135 R 1133852 CDS YP_006780452.1 407483303 13702320 complement(3866961..3868220) 1 NC_018658.1 hypothetical protein 3868220 13702320 O3K_18905 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780452.1 3866961 R 1133852 CDS YP_006780453.1 407483304 13702321 complement(3868230..3869897) 1 NC_018658.1 COG0074 Succinyl-CoA synthetase, alpha subunit; membrane protein FdrA 3869897 13702321 O3K_18910 Escherichia coli O104:H4 str. 2011C-3493 membrane protein FdrA YP_006780453.1 3868230 R 1133852 CDS YP_006780454.1 407483305 13702322 3870214..3871263 1 NC_018658.1 COG2055 Malate/L-lactate dehydrogenases; ureidoglycolate dehydrogenase 3871263 13702322 O3K_18915 Escherichia coli O104:H4 str. 2011C-3493 ureidoglycolate dehydrogenase YP_006780454.1 3870214 D 1133852 CDS YP_006780455.1 407483306 13702323 3871285..3872520 1 NC_018658.1 COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases; allantoate amidohydrolase 3872520 13702323 O3K_18920 Escherichia coli O104:H4 str. 2011C-3493 allantoate amidohydrolase YP_006780455.1 3871285 D 1133852 CDS YP_006780456.1 407483307 13702324 3872531..3873316 1 NC_018658.1 COG3257 Uncharacterized protein, possibly involved in glyoxylate utilization; hypothetical protein 3873316 13702324 O3K_18925 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780456.1 3872531 D 1133852 CDS YP_006780457.1 407483308 13702325 complement(3873445..3874590) 1 NC_018658.1 COG1929 Glycerate kinase; glycerate kinase 3874590 13702325 O3K_18930 Escherichia coli O104:H4 str. 2011C-3493 glycerate kinase YP_006780457.1 3873445 R 1133852 CDS YP_006780458.1 407483309 13702326 complement(3874612..3875913) 1 NC_018658.1 COG2233 Xanthine/uracil permeases; putative uracil/xanthine transporter 3875913 13702326 O3K_18935 Escherichia coli O104:H4 str. 2011C-3493 putative uracil/xanthine transporter YP_006780458.1 3874612 R 1133852 CDS YP_006780459.1 407483310 13702327 complement(3875970..3877331) 1 NC_018658.1 COG0044 Dihydroorotase and related cyclic amidohydrolases; allantoinase 3877331 13702327 O3K_18940 Escherichia coli O104:H4 str. 2011C-3493 allantoinase YP_006780459.1 3875970 R 1133852 CDS YP_006780460.1 407483311 13702328 complement(3877391..3878845) 1 NC_018658.1 COG1953 Cytosine/uracil/thiamine/allantoin permeases; allantoin permease 3878845 13702328 O3K_18945 Escherichia coli O104:H4 str. 2011C-3493 allantoin permease YP_006780460.1 3877391 R 1133852 CDS YP_006780461.1 407483312 13702329 complement(3879014..3879892) 1 NC_018658.1 COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases; tartronate semialdehyde reductase 3879892 13702329 O3K_18950 Escherichia coli O104:H4 str. 2011C-3493 tartronate semialdehyde reductase YP_006780461.1 3879014 R 1133852 CDS YP_006780462.1 407483313 13702330 complement(3879992..3880768) 1 NC_018658.1 COG3622 Hydroxypyruvate isomerase; hydroxypyruvate isomerase 3880768 13702330 O3K_18955 Escherichia coli O104:H4 str. 2011C-3493 hydroxypyruvate isomerase YP_006780462.1 3879992 R 1133852 CDS YP_006780463.1 407483314 13702331 complement(3880781..3882562) 1 NC_018658.1 COG3960 Glyoxylate carboligase; glyoxylate carboligase 3882562 13702331 O3K_18960 Escherichia coli O104:H4 str. 2011C-3493 glyoxylate carboligase YP_006780463.1 3880781 R 1133852 CDS YP_006780464.1 407483315 13702332 complement(3882652..3883467) 1 NC_018658.1 COG1414 Transcriptional regulator; DNA-binding transcriptional repressor AllR 3883467 13702332 O3K_18965 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional repressor AllR YP_006780464.1 3882652 R 1133852 CDS YP_006780465.1 407483316 13702333 complement(3883545..3884027) 1 NC_018658.1 COG3194 Ureidoglycolate hydrolase; ureidoglycolate hydrolase 3884027 13702333 O3K_18970 Escherichia coli O104:H4 str. 2011C-3493 ureidoglycolate hydrolase YP_006780465.1 3883545 R 1133852 CDS YP_006780466.1 407483317 13702334 3884257..3885183 1 NC_018658.1 COG0583 Transcriptional regulator; DNA-binding transcriptional activator AllS 3885183 13702334 O3K_18975 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional activator AllS YP_006780466.1 3884257 D 1133852 CDS YP_006780467.1 407483318 13702335 3885252..3886346 1 NC_018658.1 COG2603 Predicted ATPase; tRNA 2-selenouridine synthase 3886346 13702335 O3K_18980 Escherichia coli O104:H4 str. 2011C-3493 tRNA 2-selenouridine synthase YP_006780467.1 3885252 D 1133852 CDS YP_006780468.1 407483319 13702336 3886462..3886860 1 NC_018658.1 putative regulator with homeodomain-like DNA binding domain; transposase 3886860 13702336 O3K_18985 Escherichia coli O104:H4 str. 2011C-3493 transposase YP_006780468.1 3886462 D 1133852 CDS YP_006780469.1 407483320 13702337 complement(3887347..3887838) 1 NC_018658.1 hypothetical protein 3887838 13702337 O3K_18990 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780469.1 3887347 R 1133852 CDS YP_006780470.1 407483321 13702338 complement(3887819..3888529) 1 NC_018658.1 COG3209 Rhs family protein; rhs-like protein 3888529 13702338 O3K_18995 Escherichia coli O104:H4 str. 2011C-3493 rhs-like protein YP_006780470.1 3887819 R 1133852 CDS YP_006780471.1 407483322 13702339 complement(3888529..3888897) 1 NC_018658.1 hypothetical protein 3888897 13702339 O3K_19000 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780471.1 3888529 R 1133852 CDS YP_006780472.1 407483323 13702340 complement(3888937..3893226) 1 NC_018658.1 COG3209 Rhs family protein; rhsD element protein 3893226 13702340 O3K_19005 Escherichia coli O104:H4 str. 2011C-3493 rhsD element protein YP_006780472.1 3888937 R 1133852 CDS YP_006780473.1 407483324 13702341 complement(3893656..3896070) 1 NC_018658.1 COG3127 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component; ABC transporter permease 3896070 13702341 O3K_19010 Escherichia coli O104:H4 str. 2011C-3493 ABC transporter permease YP_006780473.1 3893656 R 1133852 CDS YP_006780474.1 407483325 13702342 complement(3896067..3896753) 1 NC_018658.1 COG4181 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component; ABC transporter ATP-binding protein YbbA 3896753 13702342 O3K_19015 Escherichia coli O104:H4 str. 2011C-3493 ABC transporter ATP-binding protein YbbA YP_006780474.1 3896067 R 1133852 CDS YP_006780475.1 407483326 13702343 3896721..3897347 1 NC_018658.1 COG2755 Lysophospholipase L1 and related esterases; multifunctional acyl-CoA thioesterase I/protease I/lysophospholipase L1 3897347 13702343 O3K_19020 Escherichia coli O104:H4 str. 2011C-3493 multifunctional acyl-CoA thioesterase I/protease I/lysophospholipase L1 YP_006780475.1 3896721 D 1133852 CDS YP_006780476.1 407483327 13702344 3897376..3898146 1 NC_018658.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); oxidoreductase 3898146 13702344 O3K_19025 Escherichia coli O104:H4 str. 2011C-3493 oxidoreductase YP_006780476.1 3897376 D 1133852 CDS YP_006780477.1 407483328 13702345 3898207..3899061 1 NC_018658.1 COG3118 Thioredoxin domain-containing protein; thioredoxin-like protein 3899061 13702345 O3K_19030 Escherichia coli O104:H4 str. 2011C-3493 thioredoxin-like protein YP_006780477.1 3898207 D 1133852 CDS YP_006780478.1 407483329 13702346 complement(3899124..3899903) 1 NC_018658.1 COG0390 ABC-type uncharacterized transport system, permease component; putative metal resistance protein 3899903 13702346 O3K_19035 Escherichia coli O104:H4 str. 2011C-3493 putative metal resistance protein YP_006780478.1 3899124 R 1133852 CDS YP_006780479.1 407483330 13702347 complement(3899890..3900567) 1 NC_018658.1 COG4619 ABC-type uncharacterized transport system, ATPase component; ABC transporter ATP-binding protein YbbL 3900567 13702347 O3K_19040 Escherichia coli O104:H4 str. 2011C-3493 ABC transporter ATP-binding protein YbbL YP_006780479.1 3899890 R 1133852 CDS YP_006780480.1 407483331 13702348 3900713..3901630 1 NC_018658.1 COG0330 Membrane protease subunits, stomatin/prohibitin homologs; protease 3901630 13702348 O3K_19045 Escherichia coli O104:H4 str. 2011C-3493 protease YP_006780480.1 3900713 D 1133852 CDS YP_006780481.1 407483332 13702349 3901627..3902085 1 NC_018658.1 COG1585 Membrane protein implicated in regulation of membrane protease activity; nodulation efficiency family protein 3902085 13702349 O3K_19050 Escherichia coli O104:H4 str. 2011C-3493 nodulation efficiency family protein YP_006780481.1 3901627 D 1133852 CDS YP_006780482.1 407483333 13702350 complement(3902086..3902493) 1 NC_018658.1 COG0789 Predicted transcriptional regulators; DNA-binding transcriptional regulator CueR 3902493 13702350 O3K_19055 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator CueR YP_006780482.1 3902086 R 1133852 CDS YP_006780483.1 407483334 13702351 complement(3902618..3903910) 1 NC_018658.1 COG0531 Amino acid transporters; transporter 3903910 13702351 O3K_19060 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006780483.1 3902618 R 1133852 CDS YP_006780484.1 407483335 13702352 complement(3903913..3904845) 1 NC_018658.1 COG2066 Glutaminase; glutaminase 3904845 13702352 O3K_19065 Escherichia coli O104:H4 str. 2011C-3493 glutaminase YP_006780484.1 3903913 R 1133852 CDS YP_006780485.1 407483336 13702353 3905107..3907611 1 NC_018658.1 COG2217 Cation transport ATPase; copper exporting ATPase 3907611 copA 13702353 copA Escherichia coli O104:H4 str. 2011C-3493 copper exporting ATPase YP_006780485.1 3905107 D 1133852 CDS YP_006780486.1 407483337 13702354 complement(3907725..3908066) 1 NC_018658.1 COG3093 Plasmid maintenance system antidote protein; DNA-binding transcriptional regulator 3908066 13702354 O3K_19075 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator YP_006780486.1 3907725 R 1133852 CDS YP_006780487.1 407483338 13702355 3908204..3908998 1 NC_018658.1 COG3735 Uncharacterized protein conserved in bacteria; hypothetical protein 3908998 13702355 O3K_19080 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780487.1 3908204 D 1133852 CDS YP_006780488.1 407483339 13702356 3909202..3909681 1 NC_018658.1 COG2606 Uncharacterized conserved protein; hypothetical protein 3909681 13702356 O3K_19085 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780488.1 3909202 D 1133852 CDS YP_006780489.1 407483340 13702357 complement(3909718..3911370) 1 NC_018658.1 COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; bifunctional UDP-sugar hydrolase/5'-nucleotidase 3911370 ushA 13702357 ushA Escherichia coli O104:H4 str. 2011C-3493 bifunctional UDP-sugar hydrolase/5'-nucleotidase YP_006780489.1 3909718 R 1133852 CDS YP_006780490.1 407483341 13702358 3911588..3912808 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; fosmidomycin efflux system, member of the major facilitator superfamily protein 3912808 13702358 O3K_19095 Escherichia coli O104:H4 str. 2011C-3493 fosmidomycin efflux system, member of the major facilitator superfamily protein YP_006780490.1 3911588 D 1133852 CDS YP_006780491.1 407483342 13702359 3913046..3914722 1 NC_018658.1 COG4651 Kef-type K+ transport system, predicted NAD-binding component; putative cation:proton antiport protein 3914722 13702359 O3K_19100 Escherichia coli O104:H4 str. 2011C-3493 putative cation:proton antiport protein YP_006780491.1 3913046 D 1133852 CDS YP_006780492.1 407483343 13702360 complement(3914855..3916159) 1 NC_018658.1 COG0524 Sugar kinases, ribokinase family; inosine/guanosine kinase 3916159 13702360 O3K_19105 Escherichia coli O104:H4 str. 2011C-3493 inosine/guanosine kinase YP_006780492.1 3914855 R 1133852 CDS YP_006780493.1 407483344 13702361 3916311..3917270 1 NC_018658.1 COG0657 Esterase/lipase; acetyl esterase 3917270 13702361 O3K_19110 Escherichia coli O104:H4 str. 2011C-3493 acetyl esterase YP_006780493.1 3916311 D 1133852 CDS YP_006780494.1 407483345 13702362 complement(3917267..3918229) 1 NC_018658.1 COG0276 Protoheme ferro-lyase (ferrochelatase); ferrochelatase 3918229 hemH 13702362 hemH Escherichia coli O104:H4 str. 2011C-3493 ferrochelatase YP_006780494.1 3917267 R 1133852 CDS YP_006780495.1 407483346 13702363 complement(3918465..3919109) 1 NC_018658.1 COG0563 Adenylate kinase and related kinases; adenylate kinase 3919109 adk 13702363 adk Escherichia coli O104:H4 str. 2011C-3493 adenylate kinase YP_006780495.1 3918465 R 1133852 CDS YP_006780496.1 407483347 13702364 complement(3919290..3921164) 1 NC_018658.1 COG0326 Molecular chaperone, HSP90 family; heat shock protein 90 3921164 13702364 O3K_19125 Escherichia coli O104:H4 str. 2011C-3493 heat shock protein 90 YP_006780496.1 3919290 R 1133852 CDS YP_006780497.1 407483348 13702365 complement(3921274..3921879) 1 NC_018658.1 COG0353 Recombinational DNA repair protein (RecF pathway); recombination protein RecR 3921879 recR 13702365 recR Escherichia coli O104:H4 str. 2011C-3493 recombination protein RecR YP_006780497.1 3921274 R 1133852 CDS YP_006780498.1 407483349 13702366 complement(3921879..3922208) 1 NC_018658.1 COG0718 Uncharacterized protein conserved in bacteria; hypothetical protein 3922208 13702366 O3K_19135 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780498.1 3921879 R 1133852 CDS YP_006780499.1 407483350 13702367 complement(3922261..3924192) 1 NC_018658.1 COG2812 DNA polymerase III, gamma/tau subunits; DNA polymerase III subunits gamma and tau 3924192 13702367 O3K_19140 Escherichia coli O104:H4 str. 2011C-3493 DNA polymerase III subunits gamma and tau YP_006780499.1 3922261 R 1133852 CDS YP_006780500.1 407483351 13702368 complement(3924321..3924872) 1 NC_018658.1 COG0503 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins; adenine phosphoribosyltransferase 3924872 13702368 O3K_19145 Escherichia coli O104:H4 str. 2011C-3493 adenine phosphoribosyltransferase YP_006780500.1 3924321 R 1133852 CDS YP_006780501.1 407483352 13702369 complement(3925025..3925402) 1 NC_018658.1 COG2832 Uncharacterized protein conserved in bacteria; hypothetical protein 3925402 13702369 O3K_19150 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780501.1 3925025 R 1133852 CDS YP_006780502.1 407483353 13702370 3925472..3925999 1 NC_018658.1 COG3923 Primosomal replication protein N''; primosomal replication protein N'' 3925999 13702370 O3K_19155 Escherichia coli O104:H4 str. 2011C-3493 primosomal replication protein N'' YP_006780502.1 3925472 D 1133852 CDS YP_006780503.1 407483354 13702371 3926013..3926174 1 NC_018658.1 hypothetical protein 3926174 13702371 O3K_19160 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780503.1 3926013 D 1133852 CDS YP_006780504.1 407483355 13702372 3926208..3926351 1 NC_018658.1 hypothetical protein 3926351 13702372 O3K_19165 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780504.1 3926208 D 1133852 CDS YP_006780505.1 407483356 13702373 complement(3926386..3929748) 1 NC_018658.1 COG3264 Small-conductance mechanosensitive channel; hypothetical protein 3929748 13702373 O3K_19170 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780505.1 3926386 R 1133852 CDS YP_006780506.1 407483357 13702374 complement(3929876..3930523) 1 NC_018658.1 COG1309 Transcriptional regulator; DNA-binding transcriptional repressor AcrR 3930523 13702374 O3K_19175 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional repressor AcrR YP_006780506.1 3929876 R 1133852 CDS YP_006780507.1 407483358 13702375 3930665..3931858 1 NC_018658.1 COG0845 Membrane-fusion protein; multidrug efflux system transporter AcrA 3931858 13702375 O3K_19180 Escherichia coli O104:H4 str. 2011C-3493 multidrug efflux system transporter AcrA YP_006780507.1 3930665 D 1133852 CDS YP_006780508.1 407483359 13702376 3931881..3935030 1 NC_018658.1 COG0841 Cation/multidrug efflux pump; multidrug efflux system protein AcrB 3935030 13702376 O3K_19185 Escherichia coli O104:H4 str. 2011C-3493 multidrug efflux system protein AcrB YP_006780508.1 3931881 D 1133852 CDS YP_006780509.1 407483360 13702444 3935576..3935950 1 NC_018658.1 Hha toxicity attenuator 3935950 13702444 O3K_19190 Escherichia coli O104:H4 str. 2011C-3493 Hha toxicity attenuator YP_006780509.1 3935576 D 1133852 CDS YP_006780510.1 407483361 13702445 3935976..3936194 1 NC_018658.1 modulator of gene expression, with H-NS; hemolysin expression-modulating protein 3936194 13702445 O3K_19195 Escherichia coli O104:H4 str. 2011C-3493 hemolysin expression-modulating protein YP_006780510.1 3935976 D 1133852 CDS YP_006780511.1 407483362 13702446 3936365..3936916 1 NC_018658.1 COG0110 Acetyltransferase (isoleucine patch superfamily); maltose O-acetyltransferase 3936916 13702446 O3K_19200 Escherichia coli O104:H4 str. 2011C-3493 maltose O-acetyltransferase YP_006780511.1 3936365 D 1133852 CDS YP_006780512.1 407483363 13702447 3937032..3937502 1 NC_018658.1 hypothetical protein 3937502 13702447 O3K_19205 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780512.1 3937032 D 1133852 CDS YP_006780513.1 407483364 13702448 3937666..3939216 1 NC_018658.1 COG4943 Predicted signal transduction protein containing sensor and EAL domains; hypothetical protein 3939216 13702448 O3K_19210 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780513.1 3937666 D 1133852 CDS YP_006780514.1 407483365 13702449 complement(3939258..3939611) 1 NC_018658.1 COG5507 Uncharacterized conserved protein; hypothetical protein 3939611 13702449 O3K_19215 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780514.1 3939258 R 1133852 CDS YP_006780515.1 407483366 13702450 3939912..3940301 1 NC_018658.1 COG3695 Predicted methylated DNA-protein cysteine methyltransferase; methylated-DNA-[protein]-cysteine S-methyltransferase 3940301 13702450 O3K_19220 Escherichia coli O104:H4 str. 2011C-3493 methylated-DNA-[protein]-cysteine S-methyltransferase YP_006780515.1 3939912 D 1133852 CDS YP_006780516.1 407483367 13702451 complement(3940332..3940904) 1 NC_018658.1 COG3126 Uncharacterized protein conserved in bacteria; lipoprotein 3940904 13702451 O3K_19225 Escherichia coli O104:H4 str. 2011C-3493 lipoprotein YP_006780516.1 3940332 R 1133852 CDS YP_006780517.1 407483368 13702452 3941122..3941982 1 NC_018658.1 COG1946 Acyl-CoA thioesterase; acyl-CoA thioesterase II 3941982 13702452 O3K_19230 Escherichia coli O104:H4 str. 2011C-3493 acyl-CoA thioesterase II YP_006780517.1 3941122 D 1133852 CDS YP_006780518.1 407483369 13702453 complement(3942031..3943317) 1 NC_018658.1 COG0004 Ammonia permease; ammonium transporter 3943317 13702453 O3K_19235 Escherichia coli O104:H4 str. 2011C-3493 ammonium transporter YP_006780518.1 3942031 R 1133852 CDS YP_006780519.1 407483370 13702454 complement(3943347..3943685) 1 NC_018658.1 COG0347 Nitrogen regulatory protein PII; glutamine synthetase 3943685 13702454 O3K_19240 Escherichia coli O104:H4 str. 2011C-3493 glutamine synthetase YP_006780519.1 3943347 R 1133852 CDS YP_006780520.1 407483371 13702455 complement(3943866..3945647) 1 NC_018658.1 COG1132 ABC-type multidrug transport system, ATPase and permease components; putative multidrug transporter membrane\ATP-binding protein 3945647 13702455 O3K_19245 Escherichia coli O104:H4 str. 2011C-3493 putative multidrug transporter membrane\ATP-binding protein YP_006780520.1 3943866 R 1133852 CDS YP_006780521.1 407483372 13702456 complement(3945640..3947412) 1 NC_018658.1 COG1132 ABC-type multidrug transport system, ATPase and permease components; putative multidrug transporter membrane\ATP-binding protein 3947412 13702456 O3K_19250 Escherichia coli O104:H4 str. 2011C-3493 putative multidrug transporter membrane\ATP-binding protein YP_006780521.1 3945640 R 1133852 CDS YP_006780522.1 407483373 13702457 complement(3947442..3947900) 1 NC_018658.1 COG1522 Transcriptional regulators; putative LRP-like transcriptional regulator 3947900 13702457 O3K_19255 Escherichia coli O104:H4 str. 2011C-3493 putative LRP-like transcriptional regulator YP_006780522.1 3947442 R 1133852 CDS YP_006780523.1 407483374 13702458 complement(3948053..3948871) 1 NC_018658.1 COG0561 Predicted hydrolases of the HAD superfamily; thiamin pyrimidine pyrophosphate hydrolase 3948871 13702458 O3K_19260 Escherichia coli O104:H4 str. 2011C-3493 thiamin pyrimidine pyrophosphate hydrolase YP_006780523.1 3948053 R 1133852 CDS YP_006780524.1 407483375 13702459 3948971..3950671 1 NC_018658.1 COG4533 ABC-type uncharacterized transport system, periplasmic component; hypothetical protein 3950671 13702459 O3K_19265 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780524.1 3948971 D 1133852 CDS YP_006780525.1 407483376 13702460 3950736..3951431 1 NC_018658.1 COG0603 Predicted PP-loop superfamily ATPase; queuosine biosynthesis protein QueC 3951431 13702460 O3K_19270 Escherichia coli O104:H4 str. 2011C-3493 queuosine biosynthesis protein QueC YP_006780525.1 3950736 D 1133852 CDS YP_006780526.1 407483377 13702461 complement(3951483..3951881) 1 NC_018658.1 COG0824 Predicted thioesterase; thioesterase superfamily protein 3951881 13702461 O3K_19275 Escherichia coli O104:H4 str. 2011C-3493 thioesterase superfamily protein YP_006780526.1 3951483 R 1133852 CDS YP_006780527.1 407483378 13702462 complement(3951975..3952346) 1 NC_018658.1 COG1555 DNA uptake protein and related DNA-binding proteins; hypothetical protein 3952346 13702462 O3K_19280 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780527.1 3951975 R 1133852 CDS YP_006780528.1 407483379 13702463 complement(3952497..3954368) 1 NC_018658.1 COG0760 Parvulin-like peptidyl-prolyl isomerase; chaperone 3954368 13702463 O3K_19285 Escherichia coli O104:H4 str. 2011C-3493 chaperone YP_006780528.1 3952497 R 1133852 CDS YP_006780529.1 407483380 13702464 complement(3954560..3954832) 1 NC_018658.1 COG0776 Bacterial nucleoid DNA-binding protein; transcriptional regulator HU subunit beta 3954832 13702464 O3K_19290 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator HU subunit beta YP_006780529.1 3954560 R 1133852 CDS YP_006780530.1 407483381 13702465 complement(3955041..3957395) 1 NC_018658.1 COG0466 ATP-dependent Lon protease, bacterial type; DNA-binding ATP-dependent protease La 3957395 13702465 O3K_19295 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding ATP-dependent protease La YP_006780530.1 3955041 R 1133852 CDS YP_006780531.1 407483382 13702466 complement(3957583..3958857) 1 NC_018658.1 COG1219 ATP-dependent protease Clp, ATPase subunit; ATP-dependent protease ATP-binding subunit ClpX 3958857 clpX 13702466 clpX Escherichia coli O104:H4 str. 2011C-3493 ATP-dependent protease ATP-binding subunit ClpX YP_006780531.1 3957583 R 1133852 CDS YP_006780532.1 407483383 13702467 complement(3958983..3959606) 1 NC_018658.1 COG0740 Protease subunit of ATP-dependent Clp proteases; ATP-dependent Clp protease proteolytic subunit 3959606 clpP 13702467 clpP Escherichia coli O104:H4 str. 2011C-3493 ATP-dependent Clp protease proteolytic subunit YP_006780532.1 3958983 R 1133852 CDS YP_006780533.1 407483384 13702468 complement(3959852..3961150) 1 NC_018658.1 COG0544 FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor); trigger factor 3961150 tig 13702468 tig Escherichia coli O104:H4 str. 2011C-3493 trigger factor YP_006780533.1 3959852 R 1133852 CDS YP_006780534.1 407483385 13702469 complement(3961494..3961811) 1 NC_018658.1 COG0271 Stress-induced morphogen (activity unknown); transcriptional regulator BolA 3961811 13702469 O3K_19315 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator BolA YP_006780534.1 3961494 R 1133852 CDS YP_006780535.1 407483386 13702470 3962116..3962694 1 NC_018658.1 COG3056 Uncharacterized lipoprotein; hypothetical protein 3962694 13702470 O3K_19320 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780535.1 3962116 D 1133852 CDS YP_006780536.1 407483387 13702471 3962738..3964213 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; muropeptide transporter 3964213 ampG 13702471 ampG Escherichia coli O104:H4 str. 2011C-3493 muropeptide transporter YP_006780536.1 3962738 D 1133852 CDS YP_006780537.1 407483388 13702472 3964673..3965620 1 NC_018658.1 COG1622 Heme/copper-type cytochrome/quinol oxidases, subunit 2; cytochrome o ubiquinol oxidase subunit II 3965620 13702472 O3K_19330 Escherichia coli O104:H4 str. 2011C-3493 cytochrome o ubiquinol oxidase subunit II YP_006780537.1 3964673 D 1133852 CDS YP_006780538.1 407483389 13702473 3965642..3967633 1 NC_018658.1 COG0843 Heme/copper-type cytochrome/quinol oxidases, subunit 1; cytochrome o ubiquinol oxidase subunit I 3967633 13702473 O3K_19335 Escherichia coli O104:H4 str. 2011C-3493 cytochrome o ubiquinol oxidase subunit I YP_006780538.1 3965642 D 1133852 CDS YP_006780539.1 407483390 13702474 3967623..3968237 1 NC_018658.1 COG1845 Heme/copper-type cytochrome/quinol oxidase, subunit 3; cytochrome o ubiquinol oxidase subunit III 3968237 13702474 O3K_19340 Escherichia coli O104:H4 str. 2011C-3493 cytochrome o ubiquinol oxidase subunit III YP_006780539.1 3967623 D 1133852 CDS YP_006780540.1 407483391 13702475 3968237..3968566 1 NC_018658.1 COG3125 Heme/copper-type cytochrome/quinol oxidase, subunit 4; cytochrome o ubiquinol oxidase subunit IV 3968566 13702475 O3K_19345 Escherichia coli O104:H4 str. 2011C-3493 cytochrome o ubiquinol oxidase subunit IV YP_006780540.1 3968237 D 1133852 CDS YP_006780541.1 407483392 13702476 3968578..3969468 1 NC_018658.1 COG0109 Polyprenyltransferase (cytochrome oxidase assembly factor); protoheme IX farnesyltransferase 3969468 13702476 O3K_19350 Escherichia coli O104:H4 str. 2011C-3493 protoheme IX farnesyltransferase YP_006780541.1 3968578 D 1133852 CDS YP_006780542.1 407483393 13702477 3969653..3969964 1 NC_018658.1 COG4453 Uncharacterized protein conserved in bacteria; hypothetical protein 3969964 13702477 O3K_19355 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780542.1 3969653 D 1133852 CDS YP_006780543.1 407483394 13702478 3969948..3970490 1 NC_018658.1 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; hypothetical protein 3970490 13702478 O3K_19360 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780543.1 3969948 D 1133852 CDS YP_006780544.1 407483395 13702479 complement(3970546..3971541) 1 NC_018658.1 COG0790 FOG: TPR repeat, SEL1 subfamily; zinc-dependent hydrolase 3971541 13702479 O3K_19365 Escherichia coli O104:H4 str. 2011C-3493 zinc-dependent hydrolase YP_006780544.1 3970546 R 1133852 CDS YP_006780545.1 407483396 13702480 3971889..3973253 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; major facilitator family transporter protein 3973253 13702480 O3K_19370 Escherichia coli O104:H4 str. 2011C-3493 major facilitator family transporter protein YP_006780545.1 3971889 D 1133852 CDS YP_006780546.1 407483397 13702481 complement(3973381..3973872) 1 NC_018658.1 COG1666 Uncharacterized protein conserved in bacteria; putative nucleotide-binding protein 3973872 13702481 O3K_19375 Escherichia coli O104:H4 str. 2011C-3493 putative nucleotide-binding protein YP_006780546.1 3973381 R 1133852 CDS YP_006780547.1 407483398 13702482 3974040..3974951 1 NC_018658.1 COG1893 Ketopantoate reductase; 2-dehydropantoate 2-reductase 3974951 13702482 O3K_19380 Escherichia coli O104:H4 str. 2011C-3493 2-dehydropantoate 2-reductase YP_006780547.1 3974040 D 1133852 CDS YP_006780548.1 407483399 13702483 3974914..3975504 1 NC_018658.1 COG0693 Putative intracellular protease/amidase; oxidative-stress-resistance chaperone 3975504 13702483 O3K_19385 Escherichia coli O104:H4 str. 2011C-3493 oxidative-stress-resistance chaperone YP_006780548.1 3974914 D 1133852 CDS YP_006780549.1 407483400 13702484 complement(3975558..3977006) 1 NC_018658.1 COG0301 Thiamine biosynthesis ATP pyrophosphatase; tRNA s(4)U8 sulfurtransferase 3977006 13702484 O3K_19390 Escherichia coli O104:H4 str. 2011C-3493 tRNA s(4)U8 sulfurtransferase YP_006780549.1 3975558 R 1133852 CDS YP_006780550.1 407483401 13702485 3977212..3977454 1 NC_018658.1 COG1722 Exonuclease VII small subunit; exodeoxyribonuclease VII small subunit 3977454 13702485 O3K_19395 Escherichia coli O104:H4 str. 2011C-3493 exodeoxyribonuclease VII small subunit YP_006780550.1 3977212 D 1133852 CDS YP_006780551.1 407483402 13702486 3977454..3978353 1 NC_018658.1 COG0142 Geranylgeranyl pyrophosphate synthase; geranyltranstransferase 3978353 13702486 O3K_19400 Escherichia coli O104:H4 str. 2011C-3493 geranyltranstransferase YP_006780551.1 3977454 D 1133852 CDS YP_006780552.1 407483403 13702487 3978378..3980240 1 NC_018658.1 COG1154 Deoxyxylulose-5-phosphate synthase; 1-deoxy-D-xylulose-5-phosphate synthase 3980240 13702487 O3K_19405 Escherichia coli O104:H4 str. 2011C-3493 1-deoxy-D-xylulose-5-phosphate synthase YP_006780552.1 3978378 D 1133852 CDS YP_006780553.1 407483404 13702488 3980295..3981269 1 NC_018658.1 COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases); oxidoreductase 3981269 13702488 O3K_19410 Escherichia coli O104:H4 str. 2011C-3493 oxidoreductase YP_006780553.1 3980295 D 1133852 CDS YP_006780554.1 407483405 13702489 complement(3981323..3981841) 1 NC_018658.1 COG1267 Phosphatidylglycerophosphatase A and related proteins; phosphatidylglycerophosphatase A 3981841 13702489 O3K_19415 Escherichia coli O104:H4 str. 2011C-3493 phosphatidylglycerophosphatase A YP_006780554.1 3981323 R 1133852 CDS YP_006780555.1 407483406 13702490 complement(3981819..3982796) 1 NC_018658.1 COG0611 Thiamine monophosphate kinase; thiamine monophosphate kinase 3982796 13702490 O3K_19420 Escherichia coli O104:H4 str. 2011C-3493 thiamine monophosphate kinase YP_006780555.1 3981819 R 1133852 CDS YP_006780556.1 407483407 13702491 complement(3982874..3983293) 1 NC_018658.1 COG0781 Transcription termination factor; transcription antitermination protein NusB 3983293 nusB 13702491 nusB Escherichia coli O104:H4 str. 2011C-3493 transcription antitermination protein NusB YP_006780556.1 3982874 R 1133852 CDS YP_006780557.1 407483408 13702492 complement(3983313..3983783) 1 NC_018658.1 COG0054 Riboflavin synthase beta-chain; 6,7-dimethyl-8-ribityllumazine synthase 3983783 ribH 13702492 ribH Escherichia coli O104:H4 str. 2011C-3493 6,7-dimethyl-8-ribityllumazine synthase YP_006780557.1 3983313 R 1133852 CDS YP_006780558.1 407483409 13702493 complement(3983872..3984975) 1 NC_018658.1 COG0117 Pyrimidine deaminase; bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase 3984975 ribD 13702493 ribD Escherichia coli O104:H4 str. 2011C-3493 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase YP_006780558.1 3983872 R 1133852 CDS YP_006780559.1 407483410 13702494 complement(3984979..3985428) 1 NC_018658.1 COG1327 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains; transcriptional regulator NrdR 3985428 nrdR 13702494 nrdR Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator NrdR YP_006780559.1 3984979 R 1133852 CDS YP_006780560.1 407483411 13702495 3986417..3987301 1 NC_018658.1 COG3248 Nucleoside-binding outer membrane protein; nucleoside-specific channel-forming protein Tsx 3987301 13702495 O3K_19455 Escherichia coli O104:H4 str. 2011C-3493 nucleoside-specific channel-forming protein Tsx YP_006780560.1 3986417 D 1133852 CDS YP_006780561.1 407483412 13702496 complement(3987342..3987464) 1 NC_018658.1 hypothetical protein 3987464 13702496 O3K_19460 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780561.1 3987342 R 1133852 CDS YP_006780562.1 407483413 13702497 complement(3987478..3987825) 1 NC_018658.1 COG1403 Restriction endonuclease; hypothetical protein 3987825 13702497 O3K_19465 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780562.1 3987478 R 1133852 CDS YP_006780563.1 407483414 13702498 complement(3987954..3988925) 1 NC_018658.1 COG0341 Preprotein translocase subunit SecF; preprotein translocase subunit SecF 3988925 secF 13702498 secF Escherichia coli O104:H4 str. 2011C-3493 preprotein translocase subunit SecF YP_006780563.1 3987954 R 1133852 CDS YP_006780564.1 407483415 13702499 complement(3988936..3990783) 1 NC_018658.1 COG0342 Preprotein translocase subunit SecD; preprotein translocase subunit SecD 3990783 secD 13702499 secD Escherichia coli O104:H4 str. 2011C-3493 preprotein translocase subunit SecD YP_006780564.1 3988936 R 1133852 CDS YP_006780565.1 407483416 13702500 complement(3990811..3991143) 1 NC_018658.1 COG1862 Preprotein translocase subunit YajC; preprotein translocase subunit YajC 3991143 yajC 13702500 yajC Escherichia coli O104:H4 str. 2011C-3493 preprotein translocase subunit YajC YP_006780565.1 3990811 R 1133852 CDS YP_006780566.1 407483417 13702501 complement(3991166..3992293) 1 NC_018658.1 COG0343 Queuine/archaeosine tRNA-ribosyltransferase; queuine tRNA-ribosyltransferase 3992293 tgt 13702501 tgt Escherichia coli O104:H4 str. 2011C-3493 queuine tRNA-ribosyltransferase YP_006780566.1 3991166 R 1133852 CDS YP_006780567.1 407483418 13702502 complement(3992349..3993419) 1 NC_018658.1 COG0809 S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase); S-adenosylmethionine--tRNA ribosyltransferase-isomerase 3993419 queA 13702502 queA Escherichia coli O104:H4 str. 2011C-3493 S-adenosylmethionine--tRNA ribosyltransferase-isomerase YP_006780567.1 3992349 R 1133852 CDS YP_006780568.1 407483419 13702503 3993512..3994093 1 NC_018658.1 COG3124 Uncharacterized protein conserved in bacteria; acyl carrier protein phosphodiesterase 3994093 13702503 O3K_19495 Escherichia coli O104:H4 str. 2011C-3493 acyl carrier protein phosphodiesterase YP_006780568.1 3993512 D 1133852 CDS YP_006780569.1 407483420 13702504 complement(3994098..3995915) 1 NC_018658.1 COG0366 Glycosidases; maltodextrin glucosidase 3995915 13702504 O3K_19500 Escherichia coli O104:H4 str. 2011C-3493 maltodextrin glucosidase YP_006780569.1 3994098 R 1133852 CDS YP_006780570.1 407483421 13702505 complement(3996071..3997444) 1 NC_018658.1 COG1113 Gamma-aminobutyrate permease and related permeases; putative proline-specific permease 3997444 proY 13702505 proY Escherichia coli O104:H4 str. 2011C-3493 putative proline-specific permease YP_006780570.1 3996071 R 1133852 CDS YP_006780571.1 407483422 13702506 complement(3997520..3998839) 1 NC_018658.1 COG1114 Branched-chain amino acid permeases; branched-chain amino acid transport system 2 carrier protein BrnQ 3998839 13702506 O3K_19510 Escherichia coli O104:H4 str. 2011C-3493 branched-chain amino acid transport system 2 carrier protein BrnQ YP_006780571.1 3997520 R 1133852 CDS YP_006780572.1 407483423 13702507 complement(3999246..4000541) 1 NC_018658.1 COG0642 Signal transduction histidine kinase; phosphate regulon sensor protein 4000541 phoR 13702507 phoR Escherichia coli O104:H4 str. 2011C-3493 phosphate regulon sensor protein YP_006780572.1 3999246 R 1133852 CDS YP_006780573.1 407483424 13702508 complement(4000599..4001288) 1 NC_018658.1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; transcriptional regulator PhoB 4001288 13702508 O3K_19520 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator PhoB YP_006780573.1 4000599 R 1133852 CDS YP_006780574.1 407483425 13702509 4001478..4002680 1 NC_018658.1 COG0420 DNA repair exonuclease; exonuclease subunit SbcD 4002680 13702509 O3K_19525 Escherichia coli O104:H4 str. 2011C-3493 exonuclease subunit SbcD YP_006780574.1 4001478 D 1133852 CDS YP_006780575.1 407483426 13702510 4002677..4005820 1 NC_018658.1 COG0419 ATPase involved in DNA repair; exonuclease subunit SbcC 4005820 13702510 O3K_19530 Escherichia coli O104:H4 str. 2011C-3493 exonuclease subunit SbcC YP_006780575.1 4002677 D 1133852 CDS YP_006780576.1 407483427 13702511 4005946..4007130 1 NC_018658.1 COG2814 Arabinose efflux permease; MFS transport protein AraJ 4007130 13702511 O3K_19535 Escherichia coli O104:H4 str. 2011C-3493 MFS transport protein AraJ YP_006780576.1 4005946 D 1133852 CDS YP_006780577.1 407483428 13702512 complement(4007273..4008181) 1 NC_018658.1 COG1940 Transcriptional regulator/sugar kinase; fructokinase 4008181 13702512 O3K_19540 Escherichia coli O104:H4 str. 2011C-3493 fructokinase YP_006780577.1 4007273 R 1133852 CDS YP_006780578.1 407483429 13702513 4008306..4009217 1 NC_018658.1 COG2974 DNA recombination-dependent growth factor C; exonuclease RdgC 4009217 13702513 O3K_19545 Escherichia coli O104:H4 str. 2011C-3493 exonuclease RdgC YP_006780578.1 4008306 D 1133852 CDS YP_006780579.1 407483430 13702514 complement(4009295..4009657) 1 NC_018658.1 hypothetical protein 4009657 13702514 O3K_19550 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780579.1 4009295 R 1133852 CDS YP_006780580.1 407483431 13702584 complement(4009918..4010202) 1 NC_018658.1 COG3123 Uncharacterized protein conserved in bacteria; hypothetical protein 4010202 13702584 O3K_19555 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780580.1 4009918 R 1133852 CDS YP_006780581.1 407483432 13702585 complement(4010274..4010951) 1 NC_018658.1 hypothetical protein 4010951 13702585 O3K_19560 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780581.1 4010274 R 1133852 CDS YP_006780582.1 407483433 13702586 complement(4011209..4011400) 1 NC_018658.1 hypothetical protein 4011400 13702586 O3K_19565 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780582.1 4011209 R 1133852 CDS YP_006780583.1 407483434 13702587 complement(4011450..4011974) 1 NC_018658.1 COG0703 Shikimate kinase; shikimate kinase 4011974 aroL 13702587 aroL Escherichia coli O104:H4 str. 2011C-3493 shikimate kinase YP_006780583.1 4011450 R 1133852 CDS YP_006780584.1 407483435 13702588 complement(4012157..4012615) 1 NC_018658.1 COG1671 Uncharacterized protein conserved in bacteria; hypothetical protein 4012615 13702588 O3K_19575 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780584.1 4012157 R 1133852 CDS YP_006780585.1 407483436 13702589 4012735..4013544 1 NC_018658.1 COG0345 Pyrroline-5-carboxylate reductase; pyrroline-5-carboxylate reductase 4013544 13702589 O3K_19580 Escherichia coli O104:H4 str. 2011C-3493 pyrroline-5-carboxylate reductase YP_006780585.1 4012735 D 1133852 CDS YP_006780586.1 407483437 13702590 complement(4013561..4014676) 1 NC_018658.1 COG2199 FOG: GGDEF domain; diguanylate cyclase AdrA 4014676 adrA 13702590 adrA Escherichia coli O104:H4 str. 2011C-3493 diguanylate cyclase AdrA YP_006780586.1 4013561 R 1133852 CDS YP_006780587.1 407483438 13702591 complement(4014778..4015098) 1 NC_018658.1 hypothetical protein 4015098 13702591 O3K_19590 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780587.1 4014778 R 1133852 CDS YP_006780588.1 407483439 13702592 complement(4015217..4016632) 1 NC_018658.1 COG1785 Alkaline phosphatase; alkaline phosphatase 4016632 13702592 O3K_19595 Escherichia coli O104:H4 str. 2011C-3493 alkaline phosphatase YP_006780588.1 4015217 R 1133852 CDS YP_006780589.1 407483440 13702593 complement(4016733..4016993) 1 NC_018658.1 anti-RssB factor 4016993 13702593 O3K_19600 Escherichia coli O104:H4 str. 2011C-3493 anti-RssB factor YP_006780589.1 4016733 R 1133852 CDS YP_006780590.1 407483441 13702594 4017456..4018550 1 NC_018658.1 COG1181 D-alanine-D-alanine ligase and related ATP-grasp enzymes; D-alanine--D-alanine ligase 4018550 ddl 13702594 ddl Escherichia coli O104:H4 str. 2011C-3493 D-alanine--D-alanine ligase YP_006780590.1 4017456 D 1133852 CDS YP_006780591.1 407483442 13702595 complement(4018574..4018786) 1 NC_018658.1 hypothetical protein 4018786 13702595 O3K_19610 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780591.1 4018574 R 1133852 CDS YP_006780592.1 407483443 13702596 4019046..4019354 1 NC_018658.1 hypothetical protein 4019354 13702596 O3K_19615 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780592.1 4019046 D 1133852 CDS YP_006780593.1 407483444 13702597 complement(4019413..4020507) 1 NC_018658.1 DNA-binding transcriptional regulator 4020507 13702597 O3K_19620 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator YP_006780593.1 4019413 R 1133852 CDS YP_006780594.1 407483445 13702598 complement(4020520..4021740) 1 NC_018658.1 COG1133 ABC-type long-chain fatty acid transport system, fused permease and ATPase components; microcin B17 transporter 4021740 13702598 O3K_19625 Escherichia coli O104:H4 str. 2011C-3493 microcin B17 transporter YP_006780594.1 4020520 R 1133852 CDS YP_006780595.1 407483446 13702599 4022092..4023249 1 NC_018658.1 COG1680 Beta-lactamase class C and other penicillin binding proteins; beta-lactam binding protein AmpH 4023249 13702599 O3K_19630 Escherichia coli O104:H4 str. 2011C-3493 beta-lactam binding protein AmpH YP_006780595.1 4022092 D 1133852 CDS YP_006780596.1 407483447 13702600 complement(4023250..4023873) 1 NC_018658.1 COG2186 Transcriptional regulators; putative DNA-binding transcriptional regulator 4023873 13702600 O3K_19635 Escherichia coli O104:H4 str. 2011C-3493 putative DNA-binding transcriptional regulator YP_006780596.1 4023250 R 1133852 CDS YP_006780597.1 407483448 13702601 complement(4023961..4026849) 1 NC_018658.1 COG3468 Type V secretory pathway, adhesin AidA; flagellin structural protein, protein 4026849 13702601 O3K_19640 Escherichia coli O104:H4 str. 2011C-3493 flagellin structural protein, protein YP_006780597.1 4023961 R 1133852 CDS YP_006780598.1 407483449 13702602 4027373..4028347 1 NC_018658.1 COG0113 Delta-aminolevulinic acid dehydratase; delta-aminolevulinic acid dehydratase 4028347 13702602 O3K_19645 Escherichia coli O104:H4 str. 2011C-3493 delta-aminolevulinic acid dehydratase YP_006780598.1 4027373 D 1133852 CDS YP_006780599.1 407483450 13702603 complement(4028453..4029304) 1 NC_018658.1 COG2175 Probable taurine catabolism dioxygenase; taurine dioxygenase 4029304 tauD 13702603 tauD Escherichia coli O104:H4 str. 2011C-3493 taurine dioxygenase YP_006780599.1 4028453 R 1133852 CDS YP_006780600.1 407483451 13702604 complement(4029301..4030128) 1 NC_018658.1 COG0600 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component; taurine transporter subunit 4030128 13702604 O3K_19655 Escherichia coli O104:H4 str. 2011C-3493 taurine transporter subunit YP_006780600.1 4029301 R 1133852 CDS YP_006780601.1 407483452 13702605 complement(4030125..4030892) 1 NC_018658.1 COG4525 ABC-type taurine transport system, ATPase component; taurine transporter ATP-binding subunit 4030892 tauB 13702605 tauB Escherichia coli O104:H4 str. 2011C-3493 taurine transporter ATP-binding subunit YP_006780601.1 4030125 R 1133852 CDS YP_006780602.1 407483453 13702606 complement(4030905..4031867) 1 NC_018658.1 COG4521 ABC-type taurine transport system, periplasmic component; taurine transporter substrate binding subunit 4031867 tauA 13702606 tauA Escherichia coli O104:H4 str. 2011C-3493 taurine transporter substrate binding subunit YP_006780602.1 4030905 R 1133852 CDS YP_006780603.1 407483454 13702607 4032483..4033154 1 NC_018658.1 COG2120 Uncharacterized proteins, LmbE homologs; hypothetical protein 4033154 13702607 O3K_19670 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780603.1 4032483 D 1133852 CDS YP_006780604.1 407483455 13702608 4033164..4034360 1 NC_018658.1 COG1215 Glycosyltransferases, probably involved in cell wall biogenesis; membrane-associated glycosyltransferase 4034360 13702608 O3K_19675 Escherichia coli O104:H4 str. 2011C-3493 membrane-associated glycosyltransferase YP_006780604.1 4033164 D 1133852 CDS YP_006780605.1 407483456 13702609 4034479..4034919 1 NC_018658.1 COG0110 Acetyltransferase (isoleucine patch superfamily); transferase 4034919 13702609 O3K_19680 Escherichia coli O104:H4 str. 2011C-3493 transferase YP_006780605.1 4034479 D 1133852 CDS YP_006780606.1 407483457 13702610 4034921..4035694 1 NC_018658.1 hypothetical protein 4035694 13702610 O3K_19685 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780606.1 4034921 D 1133852 CDS YP_006780607.1 407483458 13702611 4035880..4036155 1 NC_018658.1 COG1937 Uncharacterized protein conserved in bacteria; regulator protein FrmR 4036155 13702611 O3K_19690 Escherichia coli O104:H4 str. 2011C-3493 regulator protein FrmR YP_006780607.1 4035880 D 1133852 CDS YP_006780608.1 407483459 13702612 4036190..4037299 1 NC_018658.1 COG1062 Zn-dependent alcohol dehydrogenases, class III; S-(hydroxymethyl)glutathione dehydrogenase 4037299 13702612 O3K_19695 Escherichia coli O104:H4 str. 2011C-3493 S-(hydroxymethyl)glutathione dehydrogenase YP_006780608.1 4036190 D 1133852 CDS YP_006780609.1 407483460 13702613 4037392..4038225 1 NC_018658.1 COG0627 Predicted esterase; S-formylglutathione hydrolase 4038225 13702613 O3K_19700 Escherichia coli O104:H4 str. 2011C-3493 S-formylglutathione hydrolase YP_006780609.1 4037392 D 1133852 CDS YP_006780610.1 407483461 13702614 complement(4038452..4038991) 1 NC_018658.1 COG3122 Uncharacterized protein conserved in bacteria; nucleoprotein/polynucleotide-associated enzyme 4038991 13702614 O3K_19705 Escherichia coli O104:H4 str. 2011C-3493 nucleoprotein/polynucleotide-associated enzyme YP_006780610.1 4038452 R 1133852 CDS YP_006780611.1 407483462 13702615 complement(4039093..4040304) 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; putative 3-hydroxyphenylpropionic transporter MhpT 4040304 13702615 O3K_19710 Escherichia coli O104:H4 str. 2011C-3493 putative 3-hydroxyphenylpropionic transporter MhpT YP_006780611.1 4039093 R 1133852 CDS YP_006780612.1 407483463 13702616 complement(4040480..4041493) 1 NC_018658.1 COG0119 Isopropylmalate/homocitrate/citramalate synthases; 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase 4041493 13702616 O3K_19715 Escherichia coli O104:H4 str. 2011C-3493 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase YP_006780612.1 4040480 R 1133852 CDS YP_006780613.1 407483464 13702617 complement(4041490..4042440) 1 NC_018658.1 COG4569 Acetaldehyde dehydrogenase (acetylating); acetaldehyde dehydrogenase 4042440 13702617 O3K_19720 Escherichia coli O104:H4 str. 2011C-3493 acetaldehyde dehydrogenase YP_006780613.1 4041490 R 1133852 CDS YP_006780614.1 407483465 13702618 complement(4042437..4043246) 1 NC_018658.1 COG3971 2-keto-4-pentenoate hydratase; 2-keto-4-pentenoate hydratase 4043246 mhpD 13702618 mhpD Escherichia coli O104:H4 str. 2011C-3493 2-keto-4-pentenoate hydratase YP_006780614.1 4042437 R 1133852 CDS YP_006780615.1 407483466 13702619 complement(4043256..4044137) 1 NC_018658.1 COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily); 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase 4044137 13702619 O3K_19730 Escherichia coli O104:H4 str. 2011C-3493 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase YP_006780615.1 4043256 R 1133852 CDS YP_006780616.1 407483467 13702620 complement(4044140..4045084) 1 NC_018658.1 3-(2,3-dihydroxyphenyl)propionate dioxygenase 4045084 mhpB 13702620 mhpB Escherichia coli O104:H4 str. 2011C-3493 3-(2,3-dihydroxyphenyl)propionate dioxygenase YP_006780616.1 4044140 R 1133852 CDS YP_006780617.1 407483468 13702621 complement(4045086..4046750) 1 NC_018658.1 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases; 3-(3-hydroxyphenyl)propionate hydroxylase 4046750 mhpA 13702621 mhpA Escherichia coli O104:H4 str. 2011C-3493 3-(3-hydroxyphenyl)propionate hydroxylase YP_006780617.1 4045086 R 1133852 CDS YP_006780618.1 407483469 13702622 4046827..4047774 1 NC_018658.1 COG1414 Transcriptional regulator; DNA-binding transcriptional activator MhpR 4047774 13702622 O3K_19745 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional activator MhpR YP_006780618.1 4046827 D 1133852 CDS YP_006780619.1 407483470 13702623 4047851..4048933 1 NC_018658.1 COG1609 Transcriptional regulators; lac repressor 4048933 lacI 13702623 lacI Escherichia coli O104:H4 str. 2011C-3493 lac repressor YP_006780619.1 4047851 D 1133852 CDS YP_006780620.1 407483471 13702624 4049056..4052130 1 NC_018658.1 COG3250 Beta-galactosidase/beta-glucuronidase; beta-D-galactosidase 4052130 lacZ 13702624 lacZ Escherichia coli O104:H4 str. 2011C-3493 beta-D-galactosidase YP_006780620.1 4049056 D 1133852 CDS YP_006780621.1 407483472 13702625 4052182..4053435 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; galactoside permease 4053435 lacY 13702625 lacY Escherichia coli O104:H4 str. 2011C-3493 galactoside permease YP_006780621.1 4052182 D 1133852 CDS YP_006780622.1 407483473 13702626 4053501..4054112 1 NC_018658.1 COG0110 Acetyltransferase (isoleucine patch superfamily); galactoside O-acetyltransferase 4054112 lacA 13702626 lacA Escherichia coli O104:H4 str. 2011C-3493 galactoside O-acetyltransferase YP_006780622.1 4053501 D 1133852 CDS YP_006780623.1 407483474 13702627 complement(4054215..4055369) 1 NC_018658.1 COG2807 Cyanate permease; putative cyanate transporter 4055369 cynX 13702627 cynX Escherichia coli O104:H4 str. 2011C-3493 putative cyanate transporter YP_006780623.1 4054215 R 1133852 CDS YP_006780624.1 407483475 13702628 complement(4055402..4055872) 1 NC_018658.1 COG1513 Cyanate lyase; cyanate hydratase 4055872 13702628 O3K_19775 Escherichia coli O104:H4 str. 2011C-3493 cyanate hydratase YP_006780624.1 4055402 R 1133852 CDS YP_006780625.1 407483476 13702629 complement(4055903..4056562) 1 NC_018658.1 COG0288 Carbonic anhydrase; carbonate dehydratase 4056562 13702629 O3K_19780 Escherichia coli O104:H4 str. 2011C-3493 carbonate dehydratase YP_006780625.1 4055903 R 1133852 CDS YP_006780626.1 407483477 13702630 4056672..4057571 1 NC_018658.1 COG0583 Transcriptional regulator; DNA-binding transcriptional regulator CynR 4057571 13702630 O3K_19785 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator CynR YP_006780626.1 4056672 D 1133852 CDS YP_006780627.1 407483478 13702631 complement(4057611..4058894) 1 NC_018658.1 COG0402 Cytosine deaminase and related metal-dependent hydrolases; cytosine deaminase 4058894 13702631 O3K_19790 Escherichia coli O104:H4 str. 2011C-3493 cytosine deaminase YP_006780627.1 4057611 R 1133852 CDS YP_006780628.1 407483479 13702632 complement(4058884..4060143) 1 NC_018658.1 COG1457 Purine-cytosine permease and related proteins; cytosine permease 4060143 codB 13702632 codB Escherichia coli O104:H4 str. 2011C-3493 cytosine permease YP_006780628.1 4058884 R 1133852 CDS YP_006780629.1 407483480 13702633 complement(4060569..4062455) 1 NC_018658.1 COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases; propionyl-CoA synthetase 4062455 prpE 13702633 prpE Escherichia coli O104:H4 str. 2011C-3493 propionyl-CoA synthetase YP_006780629.1 4060569 R 1133852 CDS YP_006780630.1 407483481 13702634 complement(4062495..4063946) 1 NC_018658.1 COG2079 Uncharacterized protein involved in propionate catabolism; 2-methylcitrate dehydratase 4063946 prpD 13702634 prpD Escherichia coli O104:H4 str. 2011C-3493 2-methylcitrate dehydratase YP_006780630.1 4062495 R 1133852 CDS YP_006780631.1 407483482 13702635 complement(4063980..4065149) 1 NC_018658.1 COG0372 Citrate synthase; methylcitrate synthase 4065149 13702635 O3K_19810 Escherichia coli O104:H4 str. 2011C-3493 methylcitrate synthase YP_006780631.1 4063980 R 1133852 CDS YP_006780632.1 407483483 13702636 complement(4065194..4066084) 1 NC_018658.1 COG2513 PEP phosphonomutase and related enzymes; 2-methylisocitrate lyase 4066084 prpB 13702636 prpB Escherichia coli O104:H4 str. 2011C-3493 2-methylisocitrate lyase YP_006780632.1 4065194 R 1133852 CDS YP_006780633.1 407483484 13702637 4066322..4067908 1 NC_018658.1 COG3829 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains; propionate catabolism operon regulatory protein PrpR 4067908 13702637 O3K_19820 Escherichia coli O104:H4 str. 2011C-3493 propionate catabolism operon regulatory protein PrpR YP_006780633.1 4066322 D 1133852 CDS YP_006780634.1 407483485 13702638 complement(4068009..4068284) 1 NC_018658.1 hypothetical protein 4068284 13702638 O3K_19825 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780634.1 4068009 R 1133852 CDS YP_006780635.1 407483486 13702639 4068470..4069102 1 NC_018658.1 COG1280 Putative threonine efflux protein; neutral amino-acid efflux system 4069102 13702639 O3K_19830 Escherichia coli O104:H4 str. 2011C-3493 neutral amino-acid efflux system YP_006780635.1 4068470 D 1133852 CDS YP_006780636.1 407483487 13702642 complement(4069776..4070591) 1 NC_018658.1 hypothetical protein 4070591 13702642 O3K_19840 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780636.1 4069776 R 1133852 CDS YP_006780637.1 407483488 13702643 complement(4070834..4071883) 1 NC_018658.1 COG1064 Zn-dependent alcohol dehydrogenases; oxidoreductase, Zn-dependent and NAD(P)-binding protein 4071883 13702643 O3K_19845 Escherichia coli O104:H4 str. 2011C-3493 oxidoreductase, Zn-dependent and NAD(P)-binding protein YP_006780637.1 4070834 R 1133852 CDS YP_006780638.1 407483489 13702644 complement(4071970..4072926) 1 NC_018658.1 COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components; sugar ABC transporter permease 4072926 13702644 O3K_19850 Escherichia coli O104:H4 str. 2011C-3493 sugar ABC transporter permease YP_006780638.1 4071970 R 1133852 CDS YP_006780639.1 407483490 13702645 complement(4072923..4073894) 1 NC_018658.1 COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components; permease of transporter probably ribose specific 4073894 13702645 O3K_19855 Escherichia coli O104:H4 str. 2011C-3493 permease of transporter probably ribose specific YP_006780639.1 4072923 R 1133852 CDS YP_006780640.1 407483491 13702646 complement(4073887..4075371) 1 NC_018658.1 COG1129 ABC-type sugar transport system, ATPase component; sugar ABC transporter ATP-binding protein 4075371 13702646 O3K_19860 Escherichia coli O104:H4 str. 2011C-3493 sugar ABC transporter ATP-binding protein YP_006780640.1 4073887 R 1133852 CDS YP_006780641.1 407483492 13702647 complement(4075420..4076406) 1 NC_018658.1 COG1879 ABC-type sugar transport system, periplasmic component; sugar-binding protein 4076406 13702647 O3K_19865 Escherichia coli O104:H4 str. 2011C-3493 sugar-binding protein YP_006780641.1 4075420 R 1133852 CDS YP_006780642.1 407483493 13702648 complement(4076657..4077097) 1 NC_018658.1 COG4405 Uncharacterized protein conserved in bacteria; hypothetical protein 4077097 13702648 O3K_19870 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780642.1 4076657 R 1133852 CDS YP_006780643.1 407483494 13702649 complement(4078758..4079708) 1 NC_018658.1 COG0549 Carbamate kinase; putative carbamate kinase 4079708 13702649 O3K_19885 Escherichia coli O104:H4 str. 2011C-3493 putative carbamate kinase YP_006780643.1 4078758 R 1133852 CDS YP_006780644.1 407483495 13702650 complement(4079851..4081269) 1 NC_018658.1 hypothetical protein 4081269 13702650 O3K_19890 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780644.1 4079851 R 1133852 CDS YP_006780645.1 407483496 13702651 complement(4081269..4082816) 1 NC_018658.1 bacterial FdrA protein; COG0074 Succinyl-CoA synthetase, alpha subunit; acyl-CoA synthetase 4082816 13702651 O3K_19895 Escherichia coli O104:H4 str. 2011C-3493 acyl-CoA synthetase YP_006780645.1 4081269 R 1133852 CDS YP_006780646.1 407483497 13702652 complement(4082806..4083669) 1 NC_018658.1 hypothetical protein 4083669 13702652 O3K_19900 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780646.1 4082806 R 1133852 CDS YP_006780647.1 407483498 13702653 complement(4083709..4084314) 1 NC_018658.1 COG0666 FOG: Ankyrin repeat; transcriptional regulator 4084314 13702653 O3K_19905 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator YP_006780647.1 4083709 R 1133852 CDS YP_006780648.1 407483499 13702654 4084572..4085069 1 NC_018658.1 inner membrane protein 4085069 13702654 O3K_19910 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006780648.1 4084572 D 1133852 CDS YP_006780649.1 407483500 13702655 4085161..4086093 1 NC_018658.1 COG0583 Transcriptional regulator; LysR family transcriptional regulator 4086093 13702655 O3K_19915 Escherichia coli O104:H4 str. 2011C-3493 LysR family transcriptional regulator YP_006780649.1 4085161 D 1133852 CDS YP_006780650.1 407483501 13703224 complement(4086135..4087223) 1 NC_018658.1 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; putative DNA-binding transcriptional regulator 4087223 13703224 O3K_19920 Escherichia coli O104:H4 str. 2011C-3493 putative DNA-binding transcriptional regulator YP_006780650.1 4086135 R 1133852 CDS YP_006780651.1 407483502 13703225 complement(4087365..4091348) 1 NC_018658.1 COG5295 Autotransporter adhesin; AidA-I adhesin-like protein 4091348 13703225 O3K_19925 Escherichia coli O104:H4 str. 2011C-3493 AidA-I adhesin-like protein YP_006780651.1 4087365 R 1133852 CDS YP_006780652.1 407483503 13703226 complement(4091921..4093954) 1 NC_018658.1 COG1292 Choline-glycine betaine transporter; choline transport protein BetT 4093954 13703226 O3K_19930 Escherichia coli O104:H4 str. 2011C-3493 choline transport protein BetT YP_006780652.1 4091921 R 1133852 CDS YP_006780653.1 407483504 13703227 4094083..4094670 1 NC_018658.1 COG1309 Transcriptional regulator; transcriptional regulator BetI 4094670 13703227 O3K_19935 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator BetI YP_006780653.1 4094083 D 1133852 CDS YP_006780654.1 407483505 13703228 4094684..4096156 1 NC_018658.1 COG1012 NAD-dependent aldehyde dehydrogenases; betaine aldehyde dehydrogenase 4096156 13703228 O3K_19940 Escherichia coli O104:H4 str. 2011C-3493 betaine aldehyde dehydrogenase YP_006780654.1 4094684 D 1133852 CDS YP_006780655.1 407483506 13703229 4096170..4097840 1 NC_018658.1 COG2303 Choline dehydrogenase and related flavoproteins; choline dehydrogenase 4097840 13703229 O3K_19945 Escherichia coli O104:H4 str. 2011C-3493 choline dehydrogenase YP_006780655.1 4096170 D 1133852 CDS YP_006780656.1 407483507 13703230 4098053..4098718 1 NC_018658.1 inner membrane protein 4098718 13703230 O3K_19950 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006780656.1 4098053 D 1133852 CDS YP_006780657.1 407483508 13703231 complement(4098964..4099659) 1 NC_018658.1 COG1556 Uncharacterized conserved protein; hypothetical protein 4099659 13703231 O3K_19955 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780657.1 4098964 R 1133852 CDS YP_006780658.1 407483509 13703232 complement(4099652..4101079) 1 NC_018658.1 COG1139 Uncharacterized conserved protein containing a ferredoxin-like domain; oxidoreductase subunit with NAD(P)-binding domain and ferredoxin-like domain 4101079 13703232 O3K_19960 Escherichia coli O104:H4 str. 2011C-3493 oxidoreductase subunit with NAD(P)-binding domain and ferredoxin-like domain YP_006780658.1 4099652 R 1133852 CDS YP_006780659.1 407483510 13703233 complement(4101090..4101809) 1 NC_018658.1 COG0247 Fe-S oxidoreductase; oxidoreductase 4101809 13703233 O3K_19965 Escherichia coli O104:H4 str. 2011C-3493 oxidoreductase YP_006780659.1 4101090 R 1133852 CDS YP_006780660.1 407483511 13703234 complement(4102336..4103190) 1 NC_018658.1 COG2207 AraC-type DNA-binding domain-containing proteins; DNA-binding transcriptional regulator, ARAC-type 4103190 13703234 O3K_19970 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator, ARAC-type YP_006780660.1 4102336 R 1133852 CDS YP_006780661.1 407483512 13703235 4103416..4104741 1 NC_018658.1 COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes; pyridine nucleotide-disulfide oxidoreductase 4104741 13703235 O3K_19975 Escherichia coli O104:H4 str. 2011C-3493 pyridine nucleotide-disulfide oxidoreductase YP_006780661.1 4103416 D 1133852 CDS YP_006780662.1 407483513 13703236 4104850..4105086 1 NC_018658.1 hypothetical protein 4105086 13703236 O3K_19980 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780662.1 4104850 D 1133852 CDS YP_006780663.1 407483514 13703237 4105098..4105691 1 NC_018658.1 COG3059 Predicted membrane protein; hypothetical protein 4105691 13703237 O3K_19985 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780663.1 4105098 D 1133852 CDS YP_006780664.1 407483515 13703238 4106281..4107138 1 NC_018658.1 COG2207 AraC-type DNA-binding domain-containing proteins; putative transcriptional regulator ykgA 4107138 13703238 O3K_19990 Escherichia coli O104:H4 str. 2011C-3493 putative transcriptional regulator ykgA YP_006780664.1 4106281 D 1133852 CDS YP_006780665.1 407483516 13703239 complement(4107259..4111512) 1 NC_018658.1 adhesin 4111512 13703239 O3K_19995 Escherichia coli O104:H4 str. 2011C-3493 adhesin YP_006780665.1 4107259 R 1133852 CDS YP_006780666.1 407483517 13703240 4112628..4112729 1 NC_018658.1 hypothetical protein 4112729 13703240 O3K_20000 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780666.1 4112628 D 1133852 CDS YP_006780667.1 407483518 13703241 4113093..4113356 1 NC_018658.1 COG0254 Ribosomal protein L31; 50S ribosomal protein L31 4113356 rpmE2 13703241 rpmE2 Escherichia coli O104:H4 str. 2011C-3493 50S ribosomal protein L31 YP_006780667.1 4113093 D 1133852 CDS YP_006780668.1 407483519 13703242 4113356..4113496 1 NC_018658.1 COG0257 Ribosomal protein L36; 50S ribosomal protein L36 4113496 rpmJ 13703242 rpmJ Escherichia coli O104:H4 str. 2011C-3493 50S ribosomal protein L36 YP_006780668.1 4113356 D 1133852 CDS YP_006780669.1 407483520 13703243 complement(4113531..4113758) 1 NC_018658.1 hypothetical protein 4113758 13703243 O3K_20015 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780669.1 4113531 R 1133852 CDS YP_006780670.1 407483521 13703244 4114533..4115123 1 NC_018658.1 COG2771 DNA-binding HTH domain-containing proteins; transcriptional regulator 4115123 13703244 O3K_20020 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator YP_006780670.1 4114533 D 1133852 CDS YP_006780671.1 407483522 13703245 4115198..4115785 1 NC_018658.1 hypothetical protein 4115785 13703245 O3K_20025 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780671.1 4115198 D 1133852 CDS YP_006780672.1 407483523 13703246 4115843..4116511 1 NC_018658.1 chaperone 4116511 13703246 O3K_20030 Escherichia coli O104:H4 str. 2011C-3493 chaperone YP_006780672.1 4115843 D 1133852 CDS YP_006780673.1 407483524 13703247 4116537..4119062 1 NC_018658.1 hypothetical protein 4119062 13703247 O3K_20035 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780673.1 4116537 D 1133852 CDS YP_006780674.1 407483525 13703248 4119052..4120695 1 NC_018658.1 hypothetical protein 4120695 13703248 O3K_20040 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780674.1 4119052 D 1133852 CDS YP_006780675.1 407483526 13703249 4120664..4121374 1 NC_018658.1 hypothetical protein 4121374 13703249 O3K_20045 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780675.1 4120664 D 1133852 CDS YP_006780676.1 407483527 13703250 4121687..4122016 1 NC_018658.1 COG0727 Predicted Fe-S-cluster oxidoreductase; putative ferredoxin 4122016 13703250 O3K_20050 Escherichia coli O104:H4 str. 2011C-3493 putative ferredoxin YP_006780676.1 4121687 D 1133852 CDS YP_006780677.1 407483528 13703251 complement(4122264..4122878) 1 NC_018658.1 COG3477 Predicted periplasmic/secreted protein; hypothetical protein 4122878 13703251 O3K_20055 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780677.1 4122264 R 1133852 CDS YP_006780678.1 407483529 13703252 4123296..4123985 1 NC_018658.1 COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs; aldehyde oxidoreductase 2Fe-2S subunit 4123985 13703252 O3K_20060 Escherichia coli O104:H4 str. 2011C-3493 aldehyde oxidoreductase 2Fe-2S subunit YP_006780678.1 4123296 D 1133852 CDS YP_006780679.1 407483530 13703253 4123982..4124938 1 NC_018658.1 COG1319 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs; oxidoreductase 4124938 13703253 O3K_20065 Escherichia coli O104:H4 str. 2011C-3493 oxidoreductase YP_006780679.1 4123982 D 1133852 CDS YP_006780680.1 407483531 13703254 4124935..4127133 1 NC_018658.1 COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs; oxidoreductase with molybdenum-binding domain 4127133 13703254 O3K_20070 Escherichia coli O104:H4 str. 2011C-3493 oxidoreductase with molybdenum-binding domain YP_006780680.1 4124935 D 1133852 CDS YP_006780681.1 407483532 13703255 4127143..4128099 1 NC_018658.1 COG1975 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family; hypothetical protein 4128099 13703255 O3K_20075 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780681.1 4127143 D 1133852 CDS YP_006780682.1 407483533 13703256 4128078..4128488 1 NC_018658.1 COG0583 Transcriptional regulator; transcriptional regulator 4128488 13703256 O3K_20080 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator YP_006780682.1 4128078 D 1133852 CDS YP_006780683.1 407483534 13703257 complement(4128948..4129928) 1 NC_018658.1 hypothetical protein 4129928 13703257 O3K_20085 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780683.1 4128948 R 1133852 CDS YP_006780684.1 407483535 13703258 complement(4129921..4130904) 1 NC_018658.1 COG1106 Predicted ATPases; hypothetical protein 4130904 13703258 O3K_20090 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780684.1 4129921 R 1133852 CDS YP_006780685.1 407483536 13703259 complement(4131520..4132047) 1 NC_018658.1 hypothetical protein 4132047 13703259 O3K_20095 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780685.1 4131520 R 1133852 CDS YP_006780686.1 407483537 13703260 complement(4132147..4132419) 1 NC_018658.1 hypothetical protein 4132419 13703260 O3K_20100 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780686.1 4132147 R 1133852 CDS YP_006780687.1 407483538 13703261 complement(4132416..4132583) 1 NC_018658.1 hypothetical protein 4132583 13703261 O3K_20105 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780687.1 4132416 R 1133852 CDS YP_006780688.1 407483539 13703262 4132599..4132799 1 NC_018658.1 hypothetical protein 4132799 13703262 O3K_20110 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780688.1 4132599 D 1133852 CDS YP_006780689.1 407483540 13703263 complement(4132862..4133185) 1 NC_018658.1 hypothetical protein 4133185 13703263 O3K_20115 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780689.1 4132862 R 1133852 CDS YP_006780690.1 407483541 13703264 complement(4133250..4134392) 1 NC_018658.1 hypothetical protein 4134392 13703264 O3K_20120 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780690.1 4133250 R 1133852 CDS YP_006780691.1 407483542 13703265 complement(4134527..4134814) 1 NC_018658.1 Protein perC (Protein bfpW) 4134814 13703265 O3K_20125 Escherichia coli O104:H4 str. 2011C-3493 Protein perC (Protein bfpW) YP_006780691.1 4134527 R 1133852 CDS YP_006780692.1 407483543 13703266 complement(4134811..4135341) 1 NC_018658.1 COG3109 Activator of osmoprotectant transporter ProP; Activator of ProP osmoprotectant transporter 4135341 13703266 O3K_20130 Escherichia coli O104:H4 str. 2011C-3493 Activator of ProP osmoprotectant transporter YP_006780692.1 4134811 R 1133852 CDS YP_006780693.1 407483544 13703267 complement(4135827..4137959) 1 NC_018658.1 COG5519 Superfamily II helicase and inactivated derivatives; hypothetical protein 4137959 13703267 O3K_20135 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780693.1 4135827 R 1133852 CDS YP_006780694.1 407483545 13703268 complement(4137956..4138246) 1 NC_018658.1 hypothetical protein 4138246 13703268 O3K_20140 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780694.1 4137956 R 1133852 CDS YP_006780695.1 407483546 13703269 complement(4138251..4138451) 1 NC_018658.1 hypothetical protein 4138451 13703269 O3K_20145 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780695.1 4138251 R 1133852 CDS YP_006780696.1 407483547 13703270 complement(4138444..4138809) 1 NC_018658.1 hypothetical protein 4138809 13703270 O3K_20150 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780696.1 4138444 R 1133852 CDS YP_006780697.1 407483548 13703271 complement(4138820..4139167) 1 NC_018658.1 hypothetical protein 4139167 13703271 O3K_20155 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780697.1 4138820 R 1133852 CDS YP_006780698.1 407483549 13703272 4139391..4139663 1 NC_018658.1 hypothetical protein 4139663 13703272 O3K_20160 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780698.1 4139391 D 1133852 CDS YP_006780699.1 407483550 13703273 complement(4140381..4141181) 1 NC_018658.1 COG3561 Phage anti-repressor protein; AntA/AntB antirepressor 4141181 13703273 O3K_20165 Escherichia coli O104:H4 str. 2011C-3493 AntA/AntB antirepressor YP_006780699.1 4140381 R 1133852 CDS YP_006780700.1 407483551 13703274 complement(4141260..4141382) 1 NC_018658.1 COG3311 Predicted transcriptional regulator; Phage transcriptional regulator, AlpA 4141382 13703274 O3K_20170 Escherichia coli O104:H4 str. 2011C-3493 Phage transcriptional regulator, AlpA YP_006780700.1 4141260 R 1133852 CDS YP_006780701.1 407483552 13703275 complement(4141652..4142449) 1 NC_018658.1 hypothetical protein 4142449 13703275 O3K_20175 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780701.1 4141652 R 1133852 CDS YP_006780702.1 407483553 13703276 complement(4142578..4143792) 1 NC_018658.1 COG0582 Integrase; prophage CPS-53 integrase 4143792 13703276 O3K_20180 Escherichia coli O104:H4 str. 2011C-3493 prophage CPS-53 integrase YP_006780702.1 4142578 R 1133852 CDS YP_006780703.1 407483554 13703277 4144120..4145397 1 NC_018658.1 COG0582 Integrase; integrase 4145397 13703277 O3K_20185 Escherichia coli O104:H4 str. 2011C-3493 integrase YP_006780703.1 4144120 D 1133852 CDS YP_006780704.1 407483555 13703278 complement(4145478..4146155) 1 NC_018658.1 hypothetical protein 4146155 13703278 O3K_20190 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780704.1 4145478 R 1133852 CDS YP_006780705.1 407483556 13703279 complement(4146203..4148044) 1 NC_018658.1 hypothetical protein 4148044 13703279 O3K_20195 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780705.1 4146203 R 1133852 CDS YP_006780706.1 407483557 13703280 complement(4148428..4149459) 1 NC_018658.1 hypothetical protein 4149459 13703280 O3K_20200 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780706.1 4148428 R 1133852 CDS YP_006780707.1 407483558 13703281 complement(4149474..4149857) 1 NC_018658.1 hypothetical protein 4149857 13703281 O3K_20205 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780707.1 4149474 R 1133852 CDS YP_006780708.1 407483559 13703282 complement(4149862..4150059) 1 NC_018658.1 hypothetical protein 4150059 13703282 O3K_20210 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780708.1 4149862 R 1133852 CDS YP_006780709.1 407483560 13703283 complement(4151050..4151349) 1 NC_018658.1 hypothetical protein 4151349 13703283 O3K_20215 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780709.1 4151050 R 1133852 CDS YP_006780710.1 407483561 13703284 complement(4151349..4151552) 1 NC_018658.1 hypothetical protein 4151552 13703284 O3K_20220 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780710.1 4151349 R 1133852 CDS YP_006780711.1 407483562 13703285 complement(4151610..4151993) 1 NC_018658.1 hypothetical protein 4151993 13703285 O3K_20225 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780711.1 4151610 R 1133852 CDS YP_006780712.1 407483563 13703286 complement(4152091..4152360) 1 NC_018658.1 hypothetical protein 4152360 13703286 O3K_20230 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780712.1 4152091 R 1133852 CDS YP_006780713.1 407483564 13703287 complement(4152370..4153038) 1 NC_018658.1 hypothetical protein 4153038 13703287 O3K_20235 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780713.1 4152370 R 1133852 CDS YP_006780714.1 407483565 13703288 4155043..4155594 1 NC_018658.1 COG1961 Site-specific recombinases, DNA invertase Pin homologs; resolvase domain-containing protein 4155594 13703288 O3K_20240 Escherichia coli O104:H4 str. 2011C-3493 resolvase domain-containing protein YP_006780714.1 4155043 D 1133852 CDS YP_006780715.1 407483566 13703289 complement(4156160..4156312) 1 NC_018658.1 hypothetical protein 4156312 13703289 O3K_20245 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780715.1 4156160 R 1133852 CDS YP_006780716.1 407483567 13703291 complement(4157109..4158362) 1 NC_018658.1 COG0014 Gamma-glutamyl phosphate reductase; gamma-glutamyl phosphate reductase 4158362 proA 13703291 proA Escherichia coli O104:H4 str. 2011C-3493 gamma-glutamyl phosphate reductase YP_006780716.1 4157109 R 1133852 CDS YP_006780717.1 407483568 13703292 complement(4158374..4159477) 1 NC_018658.1 COG0263 Glutamate 5-kinase; gamma-glutamyl kinase 4159477 13703292 O3K_20255 Escherichia coli O104:H4 str. 2011C-3493 gamma-glutamyl kinase YP_006780717.1 4158374 R 1133852 CDS YP_006780718.1 407483569 13703293 4159765..4160820 1 NC_018658.1 COG3203 Outer membrane protein (porin); outer membrane phosphoporin protein E 4160820 13703293 O3K_20260 Escherichia coli O104:H4 str. 2011C-3493 outer membrane phosphoporin protein E YP_006780718.1 4159765 D 1133852 CDS YP_006780719.1 407483570 13703294 complement(4160859..4161260) 1 NC_018658.1 DNA-binding transcriptional regulator Crl 4161260 13703294 O3K_20265 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator Crl YP_006780719.1 4160859 R 1133852 CDS YP_006780720.1 407483571 13703295 complement(4161318..4162562) 1 NC_018658.1 COG1073 Hydrolases of the alpha/beta superfamily; fermentation/respiration switch protein 4162562 frsA 13703295 frsA Escherichia coli O104:H4 str. 2011C-3493 fermentation/respiration switch protein YP_006780720.1 4161318 R 1133852 CDS YP_006780721.1 407483572 13703296 complement(4162654..4163112) 1 NC_018658.1 COG0503 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins; xanthine-guanine phosphoribosyltransferase 4163112 13703296 O3K_20275 Escherichia coli O104:H4 str. 2011C-3493 xanthine-guanine phosphoribosyltransferase YP_006780721.1 4162654 R 1133852 CDS YP_006780722.1 407483573 13703297 4163373..4164830 1 NC_018658.1 COG2195 Di- and tripeptidases; aminoacyl-histidine dipeptidase 4164830 13703297 O3K_20280 Escherichia coli O104:H4 str. 2011C-3493 aminoacyl-histidine dipeptidase YP_006780722.1 4163373 D 1133852 CDS YP_006780723.1 407483574 13703298 complement(4164887..4165501) 1 NC_018658.1 COG1186 Protein chain release factor B; peptide chain release factor-like protein 4165501 prfH 13703298 prfH Escherichia coli O104:H4 str. 2011C-3493 peptide chain release factor-like protein YP_006780723.1 4164887 R 1133852 CDS YP_006780724.1 407483575 13703299 complement(4165498..4166637) 1 NC_018658.1 COG1690 Uncharacterized conserved protein; hypothetical protein 4166637 13703299 O3K_20290 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780724.1 4165498 R 1133852 CDS YP_006780725.1 407483576 13703300 complement(4166883..4167335) 1 NC_018658.1 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; putative acyltransferase 4167335 13703300 O3K_20295 Escherichia coli O104:H4 str. 2011C-3493 putative acyltransferase YP_006780725.1 4166883 R 1133852 CDS YP_006780726.1 407483577 13703301 complement(4167332..4168387) 1 NC_018658.1 COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair; DNA polymerase IV 4168387 13703301 O3K_20300 Escherichia coli O104:H4 str. 2011C-3493 DNA polymerase IV YP_006780726.1 4167332 R 1133852 CDS YP_006780727.1 407483578 13703302 complement(4168458..4169243) 1 NC_018658.1 COG1360 Flagellar motor protein; hypothetical protein 4169243 13703302 O3K_20305 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780727.1 4168458 R 1133852 CDS YP_006780728.1 407483579 13703303 4169188..4170927 1 NC_018658.1 COG1298 Flagellar biosynthesis pathway, component FlhA; flagellar system protein 4170927 13703303 O3K_20310 Escherichia coli O104:H4 str. 2011C-3493 flagellar system protein YP_006780728.1 4169188 D 1133852 CDS YP_006780729.1 407483580 13703304 4171032..4171310 1 NC_018658.1 hypothetical protein 4171310 13703304 O3K_20315 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780729.1 4171032 D 1133852 CDS YP_006780730.1 407483581 13703305 4171303..4171659 1 NC_018658.1 COG4226 Uncharacterized protein encoded in hypervariable junctions of pilus gene clusters; putative HicB 4171659 13703305 O3K_20320 Escherichia coli O104:H4 str. 2011C-3493 putative HicB YP_006780730.1 4171303 D 1133852 CDS YP_006780731.1 407483582 13703306 complement(4171716..4172465) 1 NC_018658.1 COG0791 Cell wall-associated hydrolases (invasion-associated proteins); hydrolase 4172465 13703306 O3K_20325 Escherichia coli O104:H4 str. 2011C-3493 hydrolase YP_006780731.1 4171716 R 1133852 CDS YP_006780732.1 407483583 13703307 4172675..4172935 1 NC_018658.1 COG3077 DNA-damage-inducible protein J; DNA-damage-inducible protein J 4172935 13703307 O3K_20330 Escherichia coli O104:H4 str. 2011C-3493 DNA-damage-inducible protein J YP_006780732.1 4172675 D 1133852 CDS YP_006780733.1 407483584 13703308 4172938..4173216 1 NC_018658.1 COG3041 Uncharacterized protein conserved in bacteria; toxin of the YafQ-DinJ toxin-antitoxin system 4173216 13703308 O3K_20335 Escherichia coli O104:H4 str. 2011C-3493 toxin of the YafQ-DinJ toxin-antitoxin system YP_006780733.1 4172938 D 1133852 CDS YP_006780734.1 407483585 13703309 4173372..4174112 1 NC_018658.1 COG3034 Uncharacterized protein conserved in bacteria; hypothetical protein 4174112 13703309 O3K_20340 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780734.1 4173372 D 1133852 CDS YP_006780735.1 407483586 13703310 complement(4174083..4174850) 1 NC_018658.1 COG0121 Predicted glutamine amidotransferase; putative amidotransfease 4174850 13703310 O3K_20345 Escherichia coli O104:H4 str. 2011C-3493 putative amidotransfease YP_006780735.1 4174083 R 1133852 CDS YP_006780736.1 407483587 13703311 complement(4175056..4175634) 1 NC_018658.1 COG0279 Phosphoheptose isomerase; phosphoheptose isomerase 4175634 gmhA 13703311 gmhA Escherichia coli O104:H4 str. 2011C-3493 phosphoheptose isomerase YP_006780736.1 4175056 R 1133852 CDS YP_006780737.1 407483588 13703312 4175874..4178318 1 NC_018658.1 COG1960 Acyl-CoA dehydrogenases; acyl-CoA dehydrogenase 4178318 fadE 13703312 fadE Escherichia coli O104:H4 str. 2011C-3493 acyl-CoA dehydrogenase YP_006780737.1 4175874 D 1133852 CDS YP_006780738.1 407483589 13703313 complement(4178361..4178834) 1 NC_018658.1 C-lysozyme inhibitor 4178834 13703313 O3K_20360 Escherichia coli O104:H4 str. 2011C-3493 C-lysozyme inhibitor YP_006780738.1 4178361 R 1133852 CDS YP_006780739.1 407483590 13703314 4178988..4179758 1 NC_018658.1 COG0388 Predicted amidohydrolase; C-N hydrolase family amidase 4179758 13703314 O3K_20365 Escherichia coli O104:H4 str. 2011C-3493 C-N hydrolase family amidase YP_006780739.1 4178988 D 1133852 CDS YP_006780740.1 407483591 13703315 complement(4179800..4180843) 1 NC_018658.1 COG5433 Transposase; transposase 4180843 13703315 O3K_20370 Escherichia coli O104:H4 str. 2011C-3493 transposase YP_006780740.1 4179800 R 1133852 CDS YP_006780741.1 407483592 13703316 complement(4182346..4182828) 1 NC_018658.1 hypothetical protein 4182828 13703316 O3K_20385 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780741.1 4182346 R 1133852 CDS YP_006780742.1 407483593 13703317 complement(4182812..4184002) 1 NC_018658.1 COG3209 Rhs family protein; putative Rhs Core protein 4184002 13703317 O3K_20390 Escherichia coli O104:H4 str. 2011C-3493 putative Rhs Core protein YP_006780742.1 4182812 R 1133852 CDS YP_006780743.1 407483594 13703318 complement(4183971..4186475) 1 NC_018658.1 COG3209 Rhs family protein; Rhs core protein 4186475 13703318 O3K_20395 Escherichia coli O104:H4 str. 2011C-3493 Rhs core protein YP_006780743.1 4183971 R 1133852 CDS YP_006780744.1 407483595 13703319 complement(4186551..4188692) 1 NC_018658.1 COG3501 Uncharacterized protein conserved in bacteria; hypothetical protein 4188692 13703319 O3K_20400 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780744.1 4186551 R 1133852 CDS YP_006780745.1 407483596 13703320 complement(4188902..4189420) 1 NC_018658.1 COG3157 Hemolysin-coregulated protein (uncharacterized); hypothetical protein 4189420 13703320 O3K_20405 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780745.1 4188902 R 1133852 CDS YP_006780746.1 407483597 13703321 complement(4189547..4189690) 1 NC_018658.1 hypothetical protein 4189690 13703321 O3K_20410 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780746.1 4189547 R 1133852 CDS YP_006780747.1 407483598 13703322 4190117..4190617 1 NC_018658.1 COG3516 Uncharacterized protein conserved in bacteria; hypothetical protein 4190617 13703322 O3K_20415 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780747.1 4190117 D 1133852 CDS YP_006780748.1 407483599 13703323 4190652..4190876 1 NC_018658.1 COG3517 Uncharacterized protein conserved in bacteria; hypothetical protein 4190876 13703323 O3K_20420 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780748.1 4190652 D 1133852 CDS YP_006780749.1 407483600 13703324 4190927..4192402 1 NC_018658.1 COG3517 Uncharacterized protein conserved in bacteria; hypothetical protein 4192402 13703324 O3K_20425 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780749.1 4190927 D 1133852 CDS YP_006780750.1 407483601 13703325 4192409..4192822 1 NC_018658.1 COG3518 Uncharacterized protein conserved in bacteria; hypothetical protein 4192822 13703325 O3K_20430 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780750.1 4192409 D 1133852 CDS YP_006780751.1 407483602 13703326 4192826..4194676 1 NC_018658.1 COG3519 Uncharacterized protein conserved in bacteria; type VI secretion system protein ImpG 4194676 13703326 O3K_20435 Escherichia coli O104:H4 str. 2011C-3493 type VI secretion system protein ImpG YP_006780751.1 4192826 D 1133852 CDS YP_006780752.1 407483603 13703327 4194640..4195722 1 NC_018658.1 COG3520 Uncharacterized protein conserved in bacteria; hypothetical protein 4195722 13703327 O3K_20440 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780752.1 4194640 D 1133852 CDS YP_006780753.1 407483604 13703328 4195747..4197027 1 NC_018658.1 COG3456 Uncharacterized conserved protein, contains FHA domain; type VI secretion system protein ImpI 4197027 13703328 O3K_20445 Escherichia coli O104:H4 str. 2011C-3493 type VI secretion system protein ImpI YP_006780753.1 4195747 D 1133852 CDS YP_006780754.1 407483605 13703329 4197024..4197548 1 NC_018658.1 COG3521 Uncharacterized protein conserved in bacteria; lipoprotein 4197548 13703329 O3K_20450 Escherichia coli O104:H4 str. 2011C-3493 lipoprotein YP_006780754.1 4197024 D 1133852 CDS YP_006780755.1 407483606 13703330 4197551..4198882 1 NC_018658.1 COG3522 Uncharacterized protein conserved in bacteria; hypothetical protein 4198882 13703330 O3K_20455 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780755.1 4197551 D 1133852 CDS YP_006780756.1 407483607 13703331 4198887..4199648 1 NC_018658.1 COG3455 Uncharacterized protein conserved in bacteria; putative membrane protein Aec26 4199648 13703331 O3K_20460 Escherichia coli O104:H4 str. 2011C-3493 putative membrane protein Aec26 YP_006780756.1 4198887 D 1133852 CDS YP_006780757.1 407483608 13703332 4199657..4202416 1 NC_018658.1 COG0542 ATPases with chaperone activity, ATP-binding subunit; ATP-dependent Clp proteinase ATP-binding subunit 4202416 13703332 O3K_20465 Escherichia coli O104:H4 str. 2011C-3493 ATP-dependent Clp proteinase ATP-binding subunit YP_006780757.1 4199657 D 1133852 CDS YP_006780758.1 407483609 13703333 4202413..4203156 1 NC_018658.1 hypothetical protein 4203156 13703333 O3K_20470 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780758.1 4202413 D 1133852 CDS YP_006780759.1 407483610 13703334 4203161..4204576 1 NC_018658.1 COG3515 Uncharacterized protein conserved in bacteria; hypothetical protein 4204576 13703334 O3K_20475 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780759.1 4203161 D 1133852 CDS YP_006780760.1 407483611 13703335 4204595..4208119 1 NC_018658.1 COG3523 Uncharacterized protein conserved in bacteria; IcmF-like protein 4208119 13703335 O3K_20480 Escherichia coli O104:H4 str. 2011C-3493 IcmF-like protein YP_006780760.1 4204595 D 1133852 CDS YP_006780761.1 407483612 13703336 4208130..4209482 1 NC_018658.1 COG3515 Uncharacterized protein conserved in bacteria; hypothetical protein 4209482 13703336 O3K_20485 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780761.1 4208130 D 1133852 CDS YP_006780762.1 407483613 13703337 4209506..4209988 1 NC_018658.1 COG3157 Hemolysin-coregulated protein (uncharacterized); hypothetical protein 4209988 13703337 O3K_20490 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780762.1 4209506 D 1133852 CDS YP_006780763.1 407483614 13703338 4210032..4210946 1 NC_018658.1 hypothetical protein 4210946 13703338 O3K_20495 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780763.1 4210032 D 1133852 CDS YP_006780764.1 407483615 13703339 4210956..4211435 1 NC_018658.1 hypothetical protein 4211435 13703339 O3K_20500 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780764.1 4210956 D 1133852 CDS YP_006780765.1 407483616 13703340 complement(4211572..4212357) 1 NC_018658.1 aminopeptidase 4212357 13703340 O3K_20505 Escherichia coli O104:H4 str. 2011C-3493 aminopeptidase YP_006780765.1 4211572 R 1133852 CDS YP_006780766.1 407483617 13703342 complement(4212893..4213624) 1 NC_018658.1 COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases; DNA polymerase III subunit epsilon 4213624 13703342 O3K_20510 Escherichia coli O104:H4 str. 2011C-3493 DNA polymerase III subunit epsilon YP_006780766.1 4212893 R 1133852 CDS YP_006780767.1 407483618 13703343 4213689..4214156 1 NC_018658.1 COG0328 Ribonuclease HI; ribonuclease H 4214156 rnhA 13703343 rnhA Escherichia coli O104:H4 str. 2011C-3493 ribonuclease H YP_006780767.1 4213689 D 1133852 CDS YP_006780768.1 407483619 13703344 complement(4214153..4214875) 1 NC_018658.1 COG0500 SAM-dependent methyltransferases; S-adenosyl-L-methionine-dependent methyltransferase 4214875 13703344 O3K_20520 Escherichia coli O104:H4 str. 2011C-3493 S-adenosyl-L-methionine-dependent methyltransferase YP_006780768.1 4214153 R 1133852 CDS YP_006780769.1 407483620 13703345 4214909..4215664 1 NC_018658.1 COG0491 Zn-dependent hydrolases, including glyoxylases; hydroxyacylglutathione hydrolase 4215664 13703345 O3K_20525 Escherichia coli O104:H4 str. 2011C-3493 hydroxyacylglutathione hydrolase YP_006780769.1 4214909 D 1133852 CDS YP_006780770.1 407483621 13703346 4215736..4217094 1 NC_018658.1 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains); membrane-bound lytic murein transglycosylase D 4217094 mltD 13703346 mltD Escherichia coli O104:H4 str. 2011C-3493 membrane-bound lytic murein transglycosylase D YP_006780770.1 4215736 D 1133852 CDS YP_006780771.1 407483622 13703347 complement(4217142..4217912) 1 NC_018658.1 COG0500 SAM-dependent methyltransferases; S-adenosyl-L-methionine-dependent methyltransferase 4217912 13703347 O3K_20535 Escherichia coli O104:H4 str. 2011C-3493 S-adenosyl-L-methionine-dependent methyltransferase YP_006780771.1 4217142 R 1133852 CDS YP_006780772.1 407483623 13703348 complement(4217990..4218790) 1 NC_018658.1 COG3021 Uncharacterized protein conserved in bacteria; hypothetical protein 4218790 13703348 O3K_20540 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780772.1 4217990 R 1133852 CDS YP_006780773.1 407483624 13703349 4219031..4219945 1 NC_018658.1 COG0583 Transcriptional regulator; LysR family transcriptional regulator 4219945 13703349 O3K_20545 Escherichia coli O104:H4 str. 2011C-3493 LysR family transcriptional regulator YP_006780773.1 4219031 D 1133852 CDS YP_006780774.1 407483625 13703350 complement(4219942..4220745) 1 NC_018658.1 COG0656 Aldo/keto reductases, related to diketogulonate reductase; 2,5-diketo-D-gluconate reductase B 4220745 dkgB 13703350 dkgB Escherichia coli O104:H4 str. 2011C-3493 2,5-diketo-D-gluconate reductase B YP_006780774.1 4219942 R 1133852 CDS YP_006780775.1 407483626 13703357 complement(4226644..4227216) 1 NC_018658.1 COG0241 Histidinol phosphatase and related phosphatases; D,D-heptose 1,7-bisphosphate phosphatase 4227216 13703357 O3K_20555 Escherichia coli O104:H4 str. 2011C-3493 D,D-heptose 1,7-bisphosphate phosphatase YP_006780775.1 4226644 R 1133852 CDS YP_006780776.1 407483627 13703358 4227404..4228435 1 NC_018658.1 COG1135 ABC-type metal ion transport system, ATPase component; DL-methionine transporter ATP-binding subunit 4228435 metN 13703358 metN Escherichia coli O104:H4 str. 2011C-3493 DL-methionine transporter ATP-binding subunit YP_006780776.1 4227404 D 1133852 CDS YP_006780777.1 407483628 13703359 4228428..4229081 1 NC_018658.1 COG2011 ABC-type metal ion transport system, permease component; DL-methionine transporter permease 4229081 13703359 O3K_20565 Escherichia coli O104:H4 str. 2011C-3493 DL-methionine transporter permease YP_006780777.1 4228428 D 1133852 CDS YP_006780778.1 407483629 13703360 4229121..4229936 1 NC_018658.1 COG1464 ABC-type metal ion transport system, periplasmic component/surface antigen; DL-methionine transporter substrate-binding subunit 4229936 metQ 13703360 metQ Escherichia coli O104:H4 str. 2011C-3493 DL-methionine transporter substrate-binding subunit YP_006780778.1 4229121 D 1133852 CDS YP_006780779.1 407483630 13703361 4230054..4230458 1 NC_018658.1 outer membrane lipoprotein 4230458 rcsF 13703361 rcsF Escherichia coli O104:H4 str. 2011C-3493 outer membrane lipoprotein YP_006780779.1 4230054 D 1133852 CDS YP_006780780.1 407483631 13703362 4230455..4231162 1 NC_018658.1 COG1720 Uncharacterized conserved protein; hypothetical protein 4231162 13703362 O3K_20580 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780780.1 4230455 D 1133852 CDS YP_006780781.1 407483632 13703363 4231274..4232992 1 NC_018658.1 COG0442 Prolyl-tRNA synthetase; prolyl-tRNA synthetase 4232992 13703363 O3K_20585 Escherichia coli O104:H4 str. 2011C-3493 prolyl-tRNA synthetase YP_006780781.1 4231274 D 1133852 CDS YP_006780782.1 407483633 13703364 4233045..4233626 1 NC_018658.1 COG0791 Cell wall-associated hydrolases (invasion-associated proteins); hypothetical protein 4233626 13703364 O3K_20590 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780782.1 4233045 D 1133852 CDS YP_006780783.1 407483634 13703365 4233632..4233868 1 NC_018658.1 hypothetical protein 4233868 13703365 O3K_20595 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780783.1 4233632 D 1133852 CDS YP_006780784.1 407483635 13703366 complement(4234072..4235052) 1 NC_018658.1 COG3547 Transposase and inactivated derivatives; IS621 transposase 4235052 13703366 O3K_20600 Escherichia coli O104:H4 str. 2011C-3493 IS621 transposase YP_006780784.1 4234072 R 1133852 CDS YP_006780785.1 407483636 13703367 complement(4235302..4236012) 1 NC_018658.1 COG3015 Uncharacterized lipoprotein NlpE involved in copper resistance; copper homeostasis and adhesion lipoprotein 4236012 13703367 O3K_20605 Escherichia coli O104:H4 str. 2011C-3493 copper homeostasis and adhesion lipoprotein YP_006780785.1 4235302 R 1133852 CDS YP_006780786.1 407483637 13703368 complement(4236026..4236448) 1 NC_018658.1 COG1186 Protein chain release factor B; hypothetical protein 4236448 13703368 O3K_20610 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780786.1 4236026 R 1133852 CDS YP_006780787.1 407483638 13703369 complement(4236445..4236990) 1 NC_018658.1 COG4681 Uncharacterized protein conserved in bacteria; hypothetical protein 4236990 13703369 O3K_20615 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780787.1 4236445 R 1133852 CDS YP_006780788.1 407483639 13703370 4237156..4237356 1 NC_018658.1 hypothetical protein 4237356 13703370 O3K_20620 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780788.1 4237156 D 1133852 CDS YP_006780789.1 407483640 13703371 4237343..4237603 1 NC_018658.1 COG4568 Transcriptional antiterminator; Rho-binding antiterminator 4237603 13703371 O3K_20625 Escherichia coli O104:H4 str. 2011C-3493 Rho-binding antiterminator YP_006780789.1 4237343 D 1133852 CDS YP_006780790.1 407483641 13703372 complement(4237652..4238950) 1 NC_018658.1 COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control; tRNA(Ile)-lysidine synthetase 4238950 tilS 13703372 tilS Escherichia coli O104:H4 str. 2011C-3493 tRNA(Ile)-lysidine synthetase YP_006780790.1 4237652 R 1133852 CDS YP_006780791.1 407483642 13703373 complement(4239015..4239404) 1 NC_018658.1 COG0346 Lactoylglutathione lyase and related lyases; putative lyase 4239404 13703373 O3K_20635 Escherichia coli O104:H4 str. 2011C-3493 putative lyase YP_006780791.1 4239015 R 1133852 CDS YP_006780792.1 407483643 13703374 complement(4239461..4241602) 1 NC_018658.1 COG1982 Arginine/lysine/ornithine decarboxylases; lysine decarboxylase LdcC 4241602 13703374 O3K_20640 Escherichia coli O104:H4 str. 2011C-3493 lysine decarboxylase LdcC YP_006780792.1 4239461 R 1133852 CDS YP_006780793.1 407483644 13703375 complement(4241701..4242660) 1 NC_018658.1 COG0825 Acetyl-CoA carboxylase alpha subunit; acetyl-CoA carboxylase carboxyltransferase subunit alpha 4242660 13703375 O3K_20645 Escherichia coli O104:H4 str. 2011C-3493 acetyl-CoA carboxylase carboxyltransferase subunit alpha YP_006780793.1 4241701 R 1133852 CDS YP_006780794.1 407483645 13703376 complement(4242673..4246155) 1 NC_018658.1 COG0587 DNA polymerase III, alpha subunit; DNA polymerase III subunit alpha 4246155 dnaE 13703376 dnaE Escherichia coli O104:H4 str. 2011C-3493 DNA polymerase III subunit alpha YP_006780794.1 4242673 R 1133852 CDS YP_006780795.1 407483646 13703377 complement(4246192..4246788) 1 NC_018658.1 COG0164 Ribonuclease HII; ribonuclease HII 4246788 rnhB 13703377 rnhB Escherichia coli O104:H4 str. 2011C-3493 ribonuclease HII YP_006780795.1 4246192 R 1133852 CDS YP_006780796.1 407483647 13703378 complement(4246785..4247933) 1 NC_018658.1 COG0763 Lipid A disaccharide synthetase; lipid-A-disaccharide synthase 4247933 lpxB 13703378 lpxB Escherichia coli O104:H4 str. 2011C-3493 lipid-A-disaccharide synthase YP_006780796.1 4246785 R 1133852 CDS YP_006780797.1 407483648 13703379 complement(4247933..4248721) 1 NC_018658.1 COG1043 Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase; UDP-N-acetylglucosamine acyltransferase 4248721 13703379 O3K_20665 Escherichia coli O104:H4 str. 2011C-3493 UDP-N-acetylglucosamine acyltransferase YP_006780797.1 4247933 R 1133852 CDS YP_006780798.1 407483649 13703380 complement(4248725..4249180) 1 NC_018658.1 COG0764 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases; (3R)-hydroxymyristoyl-ACP dehydratase 4249180 fabZ 13703380 fabZ Escherichia coli O104:H4 str. 2011C-3493 (3R)-hydroxymyristoyl-ACP dehydratase YP_006780798.1 4248725 R 1133852 CDS YP_006780799.1 407483650 13703381 complement(4249285..4250310) 1 NC_018658.1 COG1044 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 4250310 lpxD 13703381 lpxD Escherichia coli O104:H4 str. 2011C-3493 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase YP_006780799.1 4249285 R 1133852 CDS YP_006780800.1 407483651 13703382 complement(4250314..4250799) 1 NC_018658.1 COG2825 Outer membrane protein; periplasmic chaperone 4250799 13703382 O3K_20680 Escherichia coli O104:H4 str. 2011C-3493 periplasmic chaperone YP_006780800.1 4250314 R 1133852 CDS YP_006780801.1 407483652 13703383 complement(4250921..4253353) 1 NC_018658.1 COG4775 Outer membrane protein/protective antigen OMA87; outer membrane protein assembly factor YaeT 4253353 13703383 O3K_20685 Escherichia coli O104:H4 str. 2011C-3493 outer membrane protein assembly factor YaeT YP_006780801.1 4250921 R 1133852 CDS YP_006780802.1 407483653 13703384 complement(4253383..4254735) 1 NC_018658.1 COG0750 Predicted membrane-associated Zn-dependent proteases 1; zinc metallopeptidase RseP 4254735 13703384 O3K_20690 Escherichia coli O104:H4 str. 2011C-3493 zinc metallopeptidase RseP YP_006780802.1 4253383 R 1133852 CDS YP_006780803.1 407483654 13703385 complement(4254747..4255604) 1 NC_018658.1 COG0575 CDP-diglyceride synthetase; CDP-diglyceride synthase 4255604 cdsA 13703385 cdsA Escherichia coli O104:H4 str. 2011C-3493 CDP-diglyceride synthase YP_006780803.1 4254747 R 1133852 CDS YP_006780804.1 407483655 13703386 complement(4255617..4256375) 1 NC_018658.1 COG0020 Undecaprenyl pyrophosphate synthase; undecaprenyl pyrophosphate synthase 4256375 13703386 O3K_20700 Escherichia coli O104:H4 str. 2011C-3493 undecaprenyl pyrophosphate synthase YP_006780804.1 4255617 R 1133852 CDS YP_006780805.1 407483656 13703387 complement(4256564..4257760) 1 NC_018658.1 COG0743 1-deoxy-D-xylulose 5-phosphate reductoisomerase; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 4257760 13703387 O3K_20705 Escherichia coli O104:H4 str. 2011C-3493 1-deoxy-D-xylulose 5-phosphate reductoisomerase YP_006780805.1 4256564 R 1133852 CDS YP_006780806.1 407483657 13703388 complement(4257852..4258409) 1 NC_018658.1 COG0233 Ribosome recycling factor; ribosome recycling factor 4258409 frr 13703388 frr Escherichia coli O104:H4 str. 2011C-3493 ribosome recycling factor YP_006780806.1 4257852 R 1133852 CDS YP_006780807.1 407483658 13703389 complement(4258701..4259426) 1 NC_018658.1 COG0528 Uridylate kinase; uridylate kinase 4259426 pyrH 13703389 pyrH Escherichia coli O104:H4 str. 2011C-3493 uridylate kinase YP_006780807.1 4258701 R 1133852 CDS YP_006780808.1 407483659 13703390 complement(4259573..4260424) 1 NC_018658.1 COG0264 Translation elongation factor Ts; elongation factor Ts 4260424 tsf 13703390 tsf Escherichia coli O104:H4 str. 2011C-3493 elongation factor Ts YP_006780808.1 4259573 R 1133852 CDS YP_006780809.1 407483660 13703391 complement(4260682..4261407) 1 NC_018658.1 COG0052 Ribosomal protein S2; 30S ribosomal protein S2 4261407 rpsB 13703391 rpsB Escherichia coli O104:H4 str. 2011C-3493 30S ribosomal protein S2 YP_006780809.1 4260682 R 1133852 CDS YP_006780810.1 407483661 13703392 4261775..4262569 1 NC_018658.1 COG0024 Methionine aminopeptidase; methionine aminopeptidase 4262569 13703392 O3K_20730 Escherichia coli O104:H4 str. 2011C-3493 methionine aminopeptidase YP_006780810.1 4261775 D 1133852 CDS YP_006780811.1 407483662 13703393 4262631..4265303 1 NC_018658.1 COG2844 UTP:GlnB (protein PII) uridylyltransferase; PII uridylyl-transferase 4265303 13703393 O3K_20735 Escherichia coli O104:H4 str. 2011C-3493 PII uridylyl-transferase YP_006780811.1 4262631 D 1133852 CDS YP_006780812.1 407483663 13703394 4265334..4266158 1 NC_018658.1 COG2171 Tetrahydrodipicolinate N-succinyltransferase; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 4266158 dapD 13703394 dapD Escherichia coli O104:H4 str. 2011C-3493 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase YP_006780812.1 4265334 D 1133852 CDS YP_006780813.1 407483664 13703395 4266473..4266859 1 NC_018658.1 hypothetical protein 4266859 13703395 O3K_20745 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780813.1 4266473 D 1133852 CDS YP_006780814.1 407483665 13703396 complement(4266948..4268105) 1 NC_018658.1 COG3835 Sugar diacid utilization regulator; carbohydrate diacid transcriptional activator CdaR 4268105 13703396 O3K_20750 Escherichia coli O104:H4 str. 2011C-3493 carbohydrate diacid transcriptional activator CdaR YP_006780814.1 4266948 R 1133852 CDS YP_006780815.1 407483666 13703397 complement(4268260..4269684) 1 NC_018658.1 COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain; serine endoprotease 4269684 13703397 O3K_20755 Escherichia coli O104:H4 str. 2011C-3493 serine endoprotease YP_006780815.1 4268260 R 1133852 CDS YP_006780816.1 407483667 13703398 complement(4269814..4271331) 1 NC_018658.1 COG0232 dGTP triphosphohydrolase; deoxyguanosinetriphosphate triphosphohydrolase 4271331 dgt 13703398 dgt Escherichia coli O104:H4 str. 2011C-3493 deoxyguanosinetriphosphate triphosphohydrolase YP_006780816.1 4269814 R 1133852 CDS YP_006780817.1 407483668 13703399 4271415..4272113 1 NC_018658.1 COG0775 Nucleoside phosphorylase; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 4272113 13703399 O3K_20765 Escherichia coli O104:H4 str. 2011C-3493 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase YP_006780817.1 4271415 D 1133852 CDS YP_006780818.1 407483669 13703400 4272106..4272906 1 NC_018658.1 COG0614 ABC-type Fe3+-hydroxamate transport system, periplasmic component; vitamin B12-transporter protein BtuF 4272906 13703400 O3K_20770 Escherichia coli O104:H4 str. 2011C-3493 vitamin B12-transporter protein BtuF YP_006780818.1 4272106 D 1133852 CDS YP_006780819.1 407483670 13703401 4272944..4273567 1 NC_018658.1 COG2860 Predicted membrane protein; hypothetical protein 4273567 13703401 O3K_20775 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780819.1 4272944 D 1133852 CDS YP_006780820.1 407483671 13703402 complement(4273614..4273958) 1 NC_018658.1 COG0316 Uncharacterized conserved protein; iron-sulfur cluster insertion protein ErpA 4273958 13703402 O3K_20780 Escherichia coli O104:H4 str. 2011C-3493 iron-sulfur cluster insertion protein ErpA YP_006780820.1 4273614 R 1133852 CDS YP_006780821.1 407483672 13703403 complement(4274040..4275461) 1 NC_018658.1 COG0038 Chloride channel protein EriC; chloride channel protein 4275461 13703403 O3K_20785 Escherichia coli O104:H4 str. 2011C-3493 chloride channel protein YP_006780821.1 4274040 R 1133852 CDS YP_006780822.1 407483673 13703404 4275686..4276966 1 NC_018658.1 COG0001 Glutamate-1-semialdehyde aminotransferase; glutamate-1-semialdehyde aminotransferase 4276966 13703404 O3K_20790 Escherichia coli O104:H4 str. 2011C-3493 glutamate-1-semialdehyde aminotransferase YP_006780822.1 4275686 D 1133852 CDS YP_006780823.1 407483674 13703405 complement(4277001..4278983) 1 NC_018658.1 COG0609 ABC-type Fe3+-siderophore transport system, permease component; iron-hydroxamate transporter permease subunit 4278983 13703405 O3K_20795 Escherichia coli O104:H4 str. 2011C-3493 iron-hydroxamate transporter permease subunit YP_006780823.1 4277001 R 1133852 CDS YP_006780824.1 407483675 13703406 complement(4278980..4279870) 1 NC_018658.1 COG0614 ABC-type Fe3+-hydroxamate transport system, periplasmic component; iron-hydroxamate transporter substrate-binding subunit 4279870 13703406 O3K_20800 Escherichia coli O104:H4 str. 2011C-3493 iron-hydroxamate transporter substrate-binding subunit YP_006780824.1 4278980 R 1133852 CDS YP_006780825.1 407483676 13703407 complement(4279870..4280667) 1 NC_018658.1 COG1120 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components; iron-hydroxamate transporter ATP-binding subunit 4280667 13703407 O3K_20805 Escherichia coli O104:H4 str. 2011C-3493 iron-hydroxamate transporter ATP-binding subunit YP_006780825.1 4279870 R 1133852 CDS YP_006780826.1 407483677 13703408 complement(4280718..4282961) 1 NC_018658.1 COG1629 Outer membrane receptor proteins, mostly Fe transport; ferrichrome outer membrane transporter 4282961 13703408 O3K_20810 Escherichia coli O104:H4 str. 2011C-3493 ferrichrome outer membrane transporter YP_006780826.1 4280718 R 1133852 CDS YP_006780827.1 407483678 13703409 complement(4283181..4285715) 1 NC_018658.1 COG0744 Membrane carboxypeptidase (penicillin-binding protein); bifunctional glycosyl transferase/transpeptidase 4285715 mrcB 13703409 mrcB Escherichia coli O104:H4 str. 2011C-3493 bifunctional glycosyl transferase/transpeptidase YP_006780827.1 4283181 R 1133852 CDS YP_006780828.1 407483679 13703410 complement(4285702..4285872) 1 NC_018658.1 hypothetical protein 4285872 13703410 O3K_20820 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780828.1 4285702 R 1133852 CDS YP_006780829.1 407483680 13703411 complement(4285911..4288340) 1 NC_018658.1 COG1643 HrpA-like helicases; ATP-dependent RNA helicase HrpB 4288340 13703411 O3K_20825 Escherichia coli O104:H4 str. 2011C-3493 ATP-dependent RNA helicase HrpB YP_006780829.1 4285911 R 1133852 CDS YP_006780830.1 407483681 13703412 4288414..4288944 1 NC_018658.1 COG1514 2'-5' RNA ligase; 2'-5' RNA ligase 4288944 13703412 O3K_20830 Escherichia coli O104:H4 str. 2011C-3493 2'-5' RNA ligase YP_006780830.1 4288414 D 1133852 CDS YP_006780831.1 407483682 13703413 4288959..4289663 1 NC_018658.1 COG1489 DNA-binding protein, stimulates sugar fermentation; putative DNA-binding transcriptional regulator 4289663 13703413 O3K_20835 Escherichia coli O104:H4 str. 2011C-3493 putative DNA-binding transcriptional regulator YP_006780831.1 4288959 D 1133852 CDS YP_006780832.1 407483683 13703414 4289841..4290296 1 NC_018658.1 COG1734 DnaK suppressor protein; RNA polymerase-binding transcription factor 4290296 dksA 13703414 dksA Escherichia coli O104:H4 str. 2011C-3493 RNA polymerase-binding transcription factor YP_006780832.1 4289841 D 1133852 CDS YP_006780833.1 407483684 13703415 4290333..4291259 1 NC_018658.1 COG0008 Glutamyl- and glutaminyl-tRNA synthetases; glutamyl-Q tRNA(Asp) synthetase 4291259 13703415 O3K_20845 Escherichia coli O104:H4 str. 2011C-3493 glutamyl-Q tRNA(Asp) synthetase YP_006780833.1 4290333 D 1133852 CDS YP_006780834.1 407483685 13703416 4291298..4292716 1 NC_018658.1 COG0617 tRNA nucleotidyltransferase/poly(A) polymerase; poly(A) polymerase I 4292716 pcnB 13703416 pcnB Escherichia coli O104:H4 str. 2011C-3493 poly(A) polymerase I YP_006780834.1 4291298 D 1133852 CDS YP_006780835.1 407483686 13703417 4292713..4293192 1 NC_018658.1 COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase 4293192 13703417 O3K_20855 Escherichia coli O104:H4 str. 2011C-3493 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase YP_006780835.1 4292713 D 1133852 CDS YP_006780836.1 407483687 13703418 4293562..4294146 1 NC_018658.1 COG3539 P pilus assembly protein, pilin FimA; putative fimbrial-like protein 4294146 13703418 O3K_20860 Escherichia coli O104:H4 str. 2011C-3493 putative fimbrial-like protein YP_006780836.1 4293562 D 1133852 CDS YP_006780837.1 407483688 13703419 4294251..4294991 1 NC_018658.1 COG3121 P pilus assembly protein, chaperone PapD; putative chaperone protein EcpD 4294991 13703419 O3K_20865 Escherichia coli O104:H4 str. 2011C-3493 putative chaperone protein EcpD YP_006780837.1 4294251 D 1133852 CDS YP_006780838.1 407483689 13703420 4295026..4297626 1 NC_018658.1 COG3188 P pilus assembly protein, porin PapC; putative fimbrial outer membrane usher protein 4297626 13703420 O3K_20870 Escherichia coli O104:H4 str. 2011C-3493 putative fimbrial outer membrane usher protein YP_006780838.1 4295026 D 1133852 CDS YP_006780839.1 407483690 13703421 4297643..4298212 1 NC_018658.1 putative fimbrial protein 4298212 13703421 O3K_20875 Escherichia coli O104:H4 str. 2011C-3493 putative fimbrial protein YP_006780839.1 4297643 D 1133852 CDS YP_006780840.1 407483691 13703422 4298227..4298829 1 NC_018658.1 putative fimbrial protein StaE 4298829 13703422 O3K_20880 Escherichia coli O104:H4 str. 2011C-3493 putative fimbrial protein StaE YP_006780840.1 4298227 D 1133852 CDS YP_006780841.1 407483692 13703423 4298856..4299452 1 NC_018658.1 putative fimbrial protein StaF 4299452 13703423 O3K_20885 Escherichia coli O104:H4 str. 2011C-3493 putative fimbrial protein StaF YP_006780841.1 4298856 D 1133852 CDS YP_006780842.1 407483693 13703424 4299505..4300779 1 NC_018658.1 putative fimbrial-like adhesin protein 4300779 13703424 O3K_20890 Escherichia coli O104:H4 str. 2011C-3493 putative fimbrial-like adhesin protein YP_006780842.1 4299505 D 1133852 CDS YP_006780843.1 407483694 13703425 4300892..4301686 1 NC_018658.1 COG0413 Ketopantoate hydroxymethyltransferase; 3-methyl-2-oxobutanoate hydroxymethyltransferase 4301686 panB 13703425 panB Escherichia coli O104:H4 str. 2011C-3493 3-methyl-2-oxobutanoate hydroxymethyltransferase YP_006780843.1 4300892 D 1133852 CDS YP_006780844.1 407483695 13703426 4301698..4302549 1 NC_018658.1 COG0414 Panthothenate synthetase; pantoate--beta-alanine ligase 4302549 panC 13703426 panC Escherichia coli O104:H4 str. 2011C-3493 pantoate--beta-alanine ligase YP_006780844.1 4301698 D 1133852 CDS YP_006780845.1 407483696 13703427 complement(4302623..4303525) 1 NC_018658.1 transposase 4303525 13703427 O3K_20905 Escherichia coli O104:H4 str. 2011C-3493 transposase YP_006780845.1 4302623 R 1133852 CDS YP_006780846.1 407483697 13703428 4303799..4304179 1 NC_018658.1 COG0853 Aspartate 1-decarboxylase; aspartate alpha-decarboxylase 4304179 13703428 O3K_20910 Escherichia coli O104:H4 str. 2011C-3493 aspartate alpha-decarboxylase YP_006780846.1 4303799 D 1133852 CDS YP_006780847.1 407483698 13703429 complement(4304183..4305412) 1 NC_018658.1 COG0726 Predicted xylanase/chitin deacetylase; polysaccharide deacetylase 4305412 13703429 O3K_20915 Escherichia coli O104:H4 str. 2011C-3493 polysaccharide deacetylase YP_006780847.1 4304183 R 1133852 CDS YP_006780848.1 407483699 13703430 complement(4305476..4305916) 1 NC_018658.1 COG2893 Phosphotransferase system, mannose/fructose-specific component IIA; PTS system transporter subunit IIA 4305916 13703430 O3K_20920 Escherichia coli O104:H4 str. 2011C-3493 PTS system transporter subunit IIA YP_006780848.1 4305476 R 1133852 CDS YP_006780849.1 407483700 13703431 complement(4306021..4306791) 1 NC_018658.1 COG0842 ABC-type multidrug transport system, permease component; inner membrane transport permease 4306791 13703431 O3K_20925 Escherichia coli O104:H4 str. 2011C-3493 inner membrane transport permease YP_006780849.1 4306021 R 1133852 CDS YP_006780850.1 407483701 13703432 complement(4306788..4307714) 1 NC_018658.1 COG1131 ABC-type multidrug transport system, ATPase component; putative transporter subunit 4307714 13703432 O3K_20930 Escherichia coli O104:H4 str. 2011C-3493 putative transporter subunit YP_006780850.1 4306788 R 1133852 CDS YP_006780851.1 407483702 13703433 4307823..4308485 1 NC_018658.1 COG0288 Carbonic anhydrase; carbonic anhydrase 4308485 13703433 O3K_20935 Escherichia coli O104:H4 str. 2011C-3493 carbonic anhydrase YP_006780851.1 4307823 D 1133852 CDS YP_006780852.1 407483703 13703434 complement(4308526..4309062) 1 NC_018658.1 COG0634 Hypoxanthine-guanine phosphoribosyltransferase; hypoxanthine phosphoribosyltransferase 4309062 13703434 O3K_20940 Escherichia coli O104:H4 str. 2011C-3493 hypoxanthine phosphoribosyltransferase YP_006780852.1 4308526 R 1133852 CDS YP_006780853.1 407483704 13703435 4309268..4311658 1 NC_018658.1 COG4993 Glucose dehydrogenase; glucose dehydrogenase 4311658 13703435 O3K_20945 Escherichia coli O104:H4 str. 2011C-3493 glucose dehydrogenase YP_006780853.1 4309268 D 1133852 CDS YP_006780854.1 407483705 13703436 complement(4311705..4313255) 1 NC_018658.1 COG2132 Putative multicopper oxidases; multicopper oxidase 4313255 13703436 O3K_20950 Escherichia coli O104:H4 str. 2011C-3493 multicopper oxidase YP_006780854.1 4311705 R 1133852 CDS YP_006780855.1 407483706 13703437 4313421..4313768 1 NC_018658.1 hypothetical protein 4313768 13703437 O3K_20955 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780855.1 4313421 D 1133852 CDS YP_006780856.1 407483707 13703438 4313874..4314740 1 NC_018658.1 COG0421 Spermidine synthase; spermidine synthase 4314740 13703438 O3K_20960 Escherichia coli O104:H4 str. 2011C-3493 spermidine synthase YP_006780856.1 4313874 D 1133852 CDS YP_006780857.1 407483708 13703439 4314756..4315550 1 NC_018658.1 COG1586 S-adenosylmethionine decarboxylase; S-adenosylmethionine decarboxylase 4315550 13703439 O3K_20965 Escherichia coli O104:H4 str. 2011C-3493 S-adenosylmethionine decarboxylase YP_006780857.1 4314756 D 1133852 CDS YP_006780858.1 407483709 13703440 complement(4315588..4315950) 1 NC_018658.1 COG3112 Uncharacterized protein conserved in bacteria; hypothetical protein 4315950 13703440 O3K_20970 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780858.1 4315588 R 1133852 CDS YP_006780859.1 407483710 13703441 complement(4316126..4318723) 1 NC_018658.1 COG1049 Aconitase B; bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase 4318723 13703441 O3K_20975 Escherichia coli O104:H4 str. 2011C-3493 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase YP_006780859.1 4316126 R 1133852 CDS YP_006780860.1 407483711 13703442 4319078..4320835 1 NC_018658.1 hypothetical protein 4320835 13703442 O3K_20980 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780860.1 4319078 D 1133852 CDS YP_006780861.1 407483712 13703443 complement(4320906..4322330) 1 NC_018658.1 COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes; dihydrolipoamide dehydrogenase 4322330 13703443 O3K_20985 Escherichia coli O104:H4 str. 2011C-3493 dihydrolipoamide dehydrogenase YP_006780861.1 4320906 R 1133852 CDS YP_006780862.1 407483713 13703444 complement(4322655..4324547) 1 NC_018658.1 COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes; pyruvate dehydrogenase dihydrolipoyltransacetylase 4324547 aceF 13703444 aceF Escherichia coli O104:H4 str. 2011C-3493 pyruvate dehydrogenase dihydrolipoyltransacetylase YP_006780862.1 4322655 R 1133852 CDS YP_006780863.1 407483714 13703445 complement(4324562..4327225) 1 NC_018658.1 COG2609 Pyruvate dehydrogenase complex, dehydrogenase (E1) component; pyruvate dehydrogenase subunit E1 4327225 aceE 13703445 aceE Escherichia coli O104:H4 str. 2011C-3493 pyruvate dehydrogenase subunit E1 YP_006780863.1 4324562 R 1133852 CDS YP_006780864.1 407483715 13703446 complement(4327386..4328150) 1 NC_018658.1 COG2186 Transcriptional regulators; transcriptional regulator PdhR 4328150 pdhR 13703446 pdhR Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator PdhR YP_006780864.1 4327386 R 1133852 CDS YP_006780865.1 407483716 13703447 4328694..4330064 1 NC_018658.1 COG1113 Gamma-aminobutyrate permease and related permeases; aromatic amino acid transporter 4330064 13703447 O3K_21005 Escherichia coli O104:H4 str. 2011C-3493 aromatic amino acid transporter YP_006780865.1 4328694 D 1133852 CDS YP_006780866.1 407483717 13703448 complement(4330107..4330961) 1 NC_018658.1 COG1270 Cobalamin biosynthesis protein CobD/CbiB; regulatory protein AmpE 4330961 13703448 O3K_21010 Escherichia coli O104:H4 str. 2011C-3493 regulatory protein AmpE YP_006780866.1 4330107 R 1133852 CDS YP_006780867.1 407483718 13703449 complement(4330958..4331509) 1 NC_018658.1 COG3023 Negative regulator of beta-lactamase expression; N-acetyl-anhydromuranmyl-L-alanine amidase 4331509 13703449 O3K_21015 Escherichia coli O104:H4 str. 2011C-3493 N-acetyl-anhydromuranmyl-L-alanine amidase YP_006780867.1 4330958 R 1133852 CDS YP_006780868.1 407483719 13703450 4331597..4332490 1 NC_018658.1 COG0157 Nicotinate-nucleotide pyrophosphorylase; quinolinate phosphoribosyltransferase 4332490 13703450 O3K_21020 Escherichia coli O104:H4 str. 2011C-3493 quinolinate phosphoribosyltransferase YP_006780868.1 4331597 D 1133852 CDS YP_006780869.1 407483720 13703451 4332693..4333133 1 NC_018658.1 COG4969 Tfp pilus assembly protein, major pilin PilA; putative major pilin subunit 4333133 13703451 O3K_21025 Escherichia coli O104:H4 str. 2011C-3493 putative major pilin subunit YP_006780869.1 4332693 D 1133852 CDS YP_006780870.1 407483721 13703452 4333143..4334528 1 NC_018658.1 COG2804 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB; hypothetical protein 4334528 13703452 O3K_21030 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780870.1 4333143 D 1133852 CDS YP_006780871.1 407483722 13703453 4334518..4335720 1 NC_018658.1 COG1459 Type II secretory pathway, component PulF; type IV pilin biogenesis protein 4335720 13703453 O3K_21035 Escherichia coli O104:H4 str. 2011C-3493 type IV pilin biogenesis protein YP_006780871.1 4334518 D 1133852 CDS YP_006780872.1 407483723 13703454 complement(4335755..4336798) 1 NC_018658.1 COG0516 IMP dehydrogenase/GMP reductase; guanosine 5'-monophosphate oxidoreductase 4336798 13703454 O3K_21040 Escherichia coli O104:H4 str. 2011C-3493 guanosine 5'-monophosphate oxidoreductase YP_006780872.1 4335755 R 1133852 CDS YP_006780873.1 407483724 13703455 4337023..4337643 1 NC_018658.1 COG0237 Dephospho-CoA kinase; dephospho-CoA kinase 4337643 coaE 13703455 coaE Escherichia coli O104:H4 str. 2011C-3493 dephospho-CoA kinase YP_006780873.1 4337023 D 1133852 CDS YP_006780874.1 407483725 13703456 4337643..4338386 1 NC_018658.1 COG4582 Uncharacterized protein conserved in bacteria; hypothetical protein 4338386 13703456 O3K_21050 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780874.1 4337643 D 1133852 CDS YP_006780875.1 407483726 13703457 4338396..4338593 1 NC_018658.1 COG3024 Uncharacterized protein conserved in bacteria; DNA gyrase inhibitor 4338593 13703457 O3K_21055 Escherichia coli O104:H4 str. 2011C-3493 DNA gyrase inhibitor YP_006780875.1 4338396 D 1133852 CDS YP_006780876.1 407483727 13703458 complement(4338693..4339082) 1 NC_018658.1 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; nucleoside triphosphate pyrophosphohydrolase 4339082 13703458 O3K_21060 Escherichia coli O104:H4 str. 2011C-3493 nucleoside triphosphate pyrophosphohydrolase YP_006780876.1 4338693 R 1133852 CDS YP_006780877.1 407483728 13703459 complement(4339142..4341847) 1 NC_018658.1 COG0653 Preprotein translocase subunit SecA (ATPase, RNA helicase); preprotein translocase subunit SecA 4341847 13703459 O3K_21065 Escherichia coli O104:H4 str. 2011C-3493 preprotein translocase subunit SecA YP_006780877.1 4339142 R 1133852 CDS YP_006780878.1 407483729 13703460 complement(4341909..4342421) 1 NC_018658.1 SecA regulator SecM 4342421 13703460 O3K_21070 Escherichia coli O104:H4 str. 2011C-3493 SecA regulator SecM YP_006780878.1 4341909 R 1133852 CDS YP_006780879.1 407483730 13703461 complement(4342652..4343569) 1 NC_018658.1 COG0774 UDP-3-O-acyl-N-acetylglucosamine deacetylase; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 4343569 lpxC 13703461 lpxC Escherichia coli O104:H4 str. 2011C-3493 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase YP_006780879.1 4342652 R 1133852 CDS YP_006780880.1 407483731 13703462 complement(4343670..4344821) 1 NC_018658.1 COG0206 Cell division GTPase; cell division protein FtsZ 4344821 13703462 O3K_21080 Escherichia coli O104:H4 str. 2011C-3493 cell division protein FtsZ YP_006780880.1 4343670 R 1133852 CDS YP_006780881.1 407483732 13703463 complement(4344882..4346144) 1 NC_018658.1 COG0849 Actin-like ATPase involved in cell division; cell division protein FtsA 4346144 ftsA 13703463 ftsA Escherichia coli O104:H4 str. 2011C-3493 cell division protein FtsA YP_006780881.1 4344882 R 1133852 CDS YP_006780882.1 407483733 13703464 complement(4346141..4346971) 1 NC_018658.1 COG1589 Cell division septal protein; cell division protein FtsQ 4346971 13703464 O3K_21090 Escherichia coli O104:H4 str. 2011C-3493 cell division protein FtsQ YP_006780882.1 4346141 R 1133852 CDS YP_006780883.1 407483734 13703465 complement(4346973..4347893) 1 NC_018658.1 COG1181 D-alanine-D-alanine ligase and related ATP-grasp enzymes; D-alanine--D-alanine ligase 4347893 ddl 13703465 ddl Escherichia coli O104:H4 str. 2011C-3493 D-alanine--D-alanine ligase YP_006780883.1 4346973 R 1133852 CDS YP_006780884.1 407483735 13703466 complement(4347886..4349361) 1 NC_018658.1 COG0773 UDP-N-acetylmuramate-alanine ligase; UDP-N-acetylmuramate--L-alanine ligase 4349361 murC 13703466 murC Escherichia coli O104:H4 str. 2011C-3493 UDP-N-acetylmuramate--L-alanine ligase YP_006780884.1 4347886 R 1133852 CDS YP_006780885.1 407483736 13703467 complement(4349415..4350482) 1 NC_018658.1 COG0707 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase; undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase 4350482 murG 13703467 murG Escherichia coli O104:H4 str. 2011C-3493 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase YP_006780885.1 4349415 R 1133852 CDS YP_006780886.1 407483737 13703468 complement(4350479..4351723) 1 NC_018658.1 COG0772 Bacterial cell division membrane protein; cell division protein FtsW 4351723 13703468 O3K_21110 Escherichia coli O104:H4 str. 2011C-3493 cell division protein FtsW YP_006780886.1 4350479 R 1133852 CDS YP_006780887.1 407483738 13703469 complement(4351723..4353039) 1 NC_018658.1 COG0771 UDP-N-acetylmuramoylalanine-D-glutamate ligase; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 4353039 murD 13703469 murD Escherichia coli O104:H4 str. 2011C-3493 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase YP_006780887.1 4351723 R 1133852 CDS YP_006780888.1 407483739 13703470 complement(4353042..4354124) 1 NC_018658.1 COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase; phospho-N-acetylmuramoyl-pentapeptide- transferase 4354124 mraY 13703470 mraY Escherichia coli O104:H4 str. 2011C-3493 phospho-N-acetylmuramoyl-pentapeptide- transferase YP_006780888.1 4353042 R 1133852 CDS YP_006780889.1 407483740 13703471 complement(4354118..4355476) 1 NC_018658.1 COG0770 UDP-N-acetylmuramyl pentapeptide synthase; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase 4355476 murF 13703471 murF Escherichia coli O104:H4 str. 2011C-3493 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase YP_006780889.1 4354118 R 1133852 CDS YP_006780890.1 407483741 13703472 complement(4355473..4356960) 1 NC_018658.1 COG0769 UDP-N-acetylmuramyl tripeptide synthase; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 4356960 murE 13703472 murE Escherichia coli O104:H4 str. 2011C-3493 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase YP_006780890.1 4355473 R 1133852 CDS YP_006780891.1 407483742 13703473 complement(4356947..4358713) 1 NC_018658.1 COG0768 Cell division protein FtsI/penicillin-binding protein 2; peptidoglycan synthase FtsI 4358713 13703473 O3K_21135 Escherichia coli O104:H4 str. 2011C-3493 peptidoglycan synthase FtsI YP_006780891.1 4356947 R 1133852 CDS YP_006780892.1 407483743 13703474 complement(4358729..4359094) 1 NC_018658.1 COG3116 Cell division protein; cell division protein FtsL 4359094 13703474 O3K_21140 Escherichia coli O104:H4 str. 2011C-3493 cell division protein FtsL YP_006780892.1 4358729 R 1133852 CDS YP_006780893.1 407483744 13703475 complement(4359091..4360032) 1 NC_018658.1 COG0275 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis; 16S rRNA m(4)C1402 methyltransferase 4360032 13703475 O3K_21145 Escherichia coli O104:H4 str. 2011C-3493 16S rRNA m(4)C1402 methyltransferase YP_006780893.1 4359091 R 1133852 CDS YP_006780894.1 407483745 13703476 complement(4360034..4360492) 1 NC_018658.1 COG2001 Uncharacterized protein conserved in bacteria; cell division protein MraZ 4360492 13703476 O3K_21150 Escherichia coli O104:H4 str. 2011C-3493 cell division protein MraZ YP_006780894.1 4360034 R 1133852 CDS YP_006780895.1 407483746 13703477 complement(4361094..4362098) 1 NC_018658.1 COG1609 Transcriptional regulators; DNA-binding transcriptional regulator FruR 4362098 13703477 O3K_21155 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator FruR YP_006780895.1 4361094 R 1133852 CDS YP_006780896.1 407483747 13703478 complement(4362278..4362769) 1 NC_018658.1 COG0440 Acetolactate synthase, small (regulatory) subunit; acetolactate synthase 3 regulatory subunit 4362769 ilvH 13703478 ilvH Escherichia coli O104:H4 str. 2011C-3493 acetolactate synthase 3 regulatory subunit YP_006780896.1 4362278 R 1133852 CDS YP_006780897.1 407483748 13703479 complement(4362772..4364496) 1 NC_018658.1 COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; acetolactate synthase 3 catalytic subunit 4364496 13703479 O3K_21165 Escherichia coli O104:H4 str. 2011C-3493 acetolactate synthase 3 catalytic subunit YP_006780897.1 4362772 R 1133852 CDS YP_006780898.1 407483749 13703480 complement(4364814..4365758) 1 NC_018658.1 COG0583 Transcriptional regulator; leucine transcriptional activator 4365758 leuO 13703480 leuO Escherichia coli O104:H4 str. 2011C-3493 leucine transcriptional activator YP_006780898.1 4364814 R 1133852 CDS YP_006780899.1 407483750 13703481 4366418..4366504 1 NC_018658.1 leu operon leader peptide 4366504 13703481 O3K_21175 Escherichia coli O104:H4 str. 2011C-3493 leu operon leader peptide YP_006780899.1 4366418 D 1133852 CDS YP_006780900.1 407483751 13703482 4366597..4368168 1 NC_018658.1 COG0119 Isopropylmalate/homocitrate/citramalate synthases; 2-isopropylmalate synthase 4368168 13703482 O3K_21180 Escherichia coli O104:H4 str. 2011C-3493 2-isopropylmalate synthase YP_006780900.1 4366597 D 1133852 CDS YP_006780901.1 407483752 13703483 4368168..4369259 1 NC_018658.1 COG0473 Isocitrate/isopropylmalate dehydrogenase; 3-isopropylmalate dehydrogenase 4369259 13703483 O3K_21185 Escherichia coli O104:H4 str. 2011C-3493 3-isopropylmalate dehydrogenase YP_006780901.1 4368168 D 1133852 CDS YP_006780902.1 407483753 13703484 4369262..4370662 1 NC_018658.1 COG0065 3-isopropylmalate dehydratase large subunit; isopropylmalate isomerase large subunit 4370662 13703484 O3K_21190 Escherichia coli O104:H4 str. 2011C-3493 isopropylmalate isomerase large subunit YP_006780902.1 4369262 D 1133852 CDS YP_006780903.1 407483754 13703485 4370673..4371278 1 NC_018658.1 COG0066 3-isopropylmalate dehydratase small subunit; isopropylmalate isomerase small subunit 4371278 leuD 13703485 leuD Escherichia coli O104:H4 str. 2011C-3493 isopropylmalate isomerase small subunit YP_006780903.1 4370673 D 1133852 CDS YP_006780904.1 407483755 13703486 complement(4371327..4372505) 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; broad specificity sugar efflux system SetA 4372505 13703486 O3K_21200 Escherichia coli O104:H4 str. 2011C-3493 broad specificity sugar efflux system SetA YP_006780904.1 4371327 R 1133852 CDS YP_006780905.1 407483756 13703487 complement(4372607..4372738) 1 NC_018658.1 hypothetical protein 4372738 13703487 O3K_21205 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780905.1 4372607 R 1133852 CDS YP_006780906.1 407483757 13703488 4372827..4374482 1 NC_018658.1 COG4533 ABC-type uncharacterized transport system, periplasmic component; transcriptional regulator SgrR 4374482 13703488 O3K_21210 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator SgrR YP_006780906.1 4372827 D 1133852 CDS YP_006780907.1 407483758 13703489 4374646..4375629 1 NC_018658.1 COG4143 ABC-type thiamine transport system, periplasmic component; thiamine transporter substrate binding subunit 4375629 tbpA 13703489 tbpA Escherichia coli O104:H4 str. 2011C-3493 thiamine transporter substrate binding subunit YP_006780907.1 4374646 D 1133852 CDS YP_006780908.1 407483759 13703490 4375605..4377215 1 NC_018658.1 COG0555 ABC-type sulfate transport system, permease component; thiamine transporter membrane protein 4377215 thiP 13703490 thiP Escherichia coli O104:H4 str. 2011C-3493 thiamine transporter membrane protein YP_006780908.1 4375605 D 1133852 CDS YP_006780909.1 407483760 13703491 4377199..4377897 1 NC_018658.1 COG3840 ABC-type thiamine transport system, ATPase component; thiamine transporter ATP-binding subunit 4377897 thiQ 13703491 thiQ Escherichia coli O104:H4 str. 2011C-3493 thiamine transporter ATP-binding subunit YP_006780909.1 4377199 D 1133852 CDS YP_006780910.1 407483761 13703492 complement(4378011..4378775) 1 NC_018658.1 COG0586 Uncharacterized membrane-associated protein; hypothetical protein 4378775 13703492 O3K_21230 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780910.1 4378011 R 1133852 CDS YP_006780911.1 407483762 13703493 complement(4378861..4379739) 1 NC_018658.1 COG2207 AraC-type DNA-binding domain-containing proteins; DNA-binding transcriptional regulator AraC 4379739 13703493 O3K_21235 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator AraC YP_006780911.1 4378861 R 1133852 CDS YP_006780912.1 407483763 13703494 4380078..4381778 1 NC_018658.1 COG1069 Ribulose kinase; ribulokinase 4381778 13703494 O3K_21240 Escherichia coli O104:H4 str. 2011C-3493 ribulokinase YP_006780912.1 4380078 D 1133852 CDS YP_006780913.1 407483764 13703495 4381789..4383291 1 NC_018658.1 COG2160 L-arabinose isomerase; L-arabinose isomerase 4383291 13703495 O3K_21245 Escherichia coli O104:H4 str. 2011C-3493 L-arabinose isomerase YP_006780913.1 4381789 D 1133852 CDS YP_006780914.1 407483765 13703496 4383460..4384155 1 NC_018658.1 COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases; L-ribulose-5-phosphate 4-epimerase 4384155 araD 13703496 araD Escherichia coli O104:H4 str. 2011C-3493 L-ribulose-5-phosphate 4-epimerase YP_006780914.1 4383460 D 1133852 CDS YP_006780915.1 407483766 13703497 4384230..4386581 1 NC_018658.1 COG0417 DNA polymerase elongation subunit (family B); DNA polymerase II 4386581 13703497 O3K_21255 Escherichia coli O104:H4 str. 2011C-3493 DNA polymerase II YP_006780915.1 4384230 D 1133852 CDS YP_006780916.1 407483767 13703498 4386746..4389652 1 NC_018658.1 COG0553 Superfamily II DNA/RNA helicases, SNF2 family; ATP-dependent helicase HepA 4389652 13703498 O3K_21260 Escherichia coli O104:H4 str. 2011C-3493 ATP-dependent helicase HepA YP_006780916.1 4386746 D 1133852 CDS YP_006780917.1 407483768 13703499 4389664..4390323 1 NC_018658.1 COG0564 Pseudouridylate synthases, 23S RNA-specific; 23S rRNA/tRNA pseudouridine synthase A 4390323 13703499 O3K_21265 Escherichia coli O104:H4 str. 2011C-3493 23S rRNA/tRNA pseudouridine synthase A YP_006780917.1 4389664 D 1133852 CDS YP_006780918.1 407483769 13703500 complement(4390440..4391255) 1 NC_018658.1 COG1076 DnaJ-domain-containing proteins 1; Dna-J like membrane chaperone protein 4391255 djlA 13703500 djlA Escherichia coli O104:H4 str. 2011C-3493 Dna-J like membrane chaperone protein YP_006780918.1 4390440 R 1133852 CDS YP_006780919.1 407483770 13703501 4391510..4393864 1 NC_018658.1 COG1452 Organic solvent tolerance protein OstA; LPS assembly outer membrane complex protein LptD 4393864 13703501 O3K_21275 Escherichia coli O104:H4 str. 2011C-3493 LPS assembly outer membrane complex protein LptD YP_006780919.1 4391510 D 1133852 CDS YP_006780920.1 407483771 13703502 4393917..4395203 1 NC_018658.1 COG0760 Parvulin-like peptidyl-prolyl isomerase; peptidyl-prolyl cis-trans isomerase SurA 4395203 13703502 O3K_21280 Escherichia coli O104:H4 str. 2011C-3493 peptidyl-prolyl cis-trans isomerase SurA YP_006780920.1 4393917 D 1133852 CDS YP_006780921.1 407483772 13703503 4395203..4396192 1 NC_018658.1 COG1995 Pyridoxal phosphate biosynthesis protein; 4-hydroxythreonine-4-phosphate dehydrogenase 4396192 pdxA 13703503 pdxA Escherichia coli O104:H4 str. 2011C-3493 4-hydroxythreonine-4-phosphate dehydrogenase YP_006780921.1 4395203 D 1133852 CDS YP_006780922.1 407483773 13703504 4396189..4397010 1 NC_018658.1 COG0030 Dimethyladenosine transferase (rRNA methylation); KsgA/Dim1 family 16S ribosomal RNA methyltransferase 4397010 ksgA 13703504 ksgA Escherichia coli O104:H4 str. 2011C-3493 KsgA/Dim1 family 16S ribosomal RNA methyltransferase YP_006780922.1 4396189 D 1133852 CDS YP_006780923.1 407483774 13703505 4397013..4397390 1 NC_018658.1 COG2967 Uncharacterized protein affecting Mg2+/Co2+ transport; CO2+/MG2+ efflux protein ApaG 4397390 apaG 13703505 apaG Escherichia coli O104:H4 str. 2011C-3493 CO2+/MG2+ efflux protein ApaG YP_006780923.1 4397013 D 1133852 CDS YP_006780924.1 407483775 13703506 4397397..4398239 1 NC_018658.1 COG0639 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases; diadenosine tetraphosphatase 4398239 apaH 13703506 apaH Escherichia coli O104:H4 str. 2011C-3493 diadenosine tetraphosphatase YP_006780924.1 4397397 D 1133852 CDS YP_006780925.1 407483776 13703507 complement(4398317..4398796) 1 NC_018658.1 COG0262 Dihydrofolate reductase; dihydrofolate reductase 4398796 folA 13703507 folA Escherichia coli O104:H4 str. 2011C-3493 dihydrofolate reductase YP_006780925.1 4398317 R 1133852 CDS YP_006780926.1 407483777 13703508 complement(4398988..4400850) 1 NC_018658.1 COG0475 Kef-type K+ transport systems, membrane components; glutathione-regulated potassium-efflux system protein KefC 4400850 13703508 O3K_21310 Escherichia coli O104:H4 str. 2011C-3493 glutathione-regulated potassium-efflux system protein KefC YP_006780926.1 4398988 R 1133852 CDS YP_006780927.1 407483778 13703509 complement(4400843..4401373) 1 NC_018658.1 COG2249 Putative NADPH-quinone reductase (modulator of drug activity B); glutathione-regulated potassium-efflux system ancillary protein KefF 4401373 13703509 O3K_21315 Escherichia coli O104:H4 str. 2011C-3493 glutathione-regulated potassium-efflux system ancillary protein KefF YP_006780927.1 4400843 R 1133852 CDS YP_006780928.1 407483779 13703510 complement(4401481..4402812) 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; transporter 4402812 13703510 O3K_21320 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006780928.1 4401481 R 1133852 CDS YP_006780929.1 407483780 13703511 complement(4402871..4403158) 1 NC_018658.1 COG2440 Ferredoxin-like protein; ferredoxin-like protein FixX 4403158 13703511 O3K_21325 Escherichia coli O104:H4 str. 2011C-3493 ferredoxin-like protein FixX YP_006780929.1 4402871 R 1133852 CDS YP_006780930.1 407483781 13703512 complement(4403155..4404441) 1 NC_018658.1 COG0644 Dehydrogenases (flavoproteins); putative oxidoreductase FixC 4404441 13703512 O3K_21330 Escherichia coli O104:H4 str. 2011C-3493 putative oxidoreductase FixC YP_006780930.1 4403155 R 1133852 CDS YP_006780931.1 407483782 13703513 complement(4404492..4405433) 1 NC_018658.1 COG2025 Electron transfer flavoprotein, alpha subunit; putative electron transfer flavoprotein FixB 4405433 fixB 13703513 fixB Escherichia coli O104:H4 str. 2011C-3493 putative electron transfer flavoprotein FixB YP_006780931.1 4404492 R 1133852 CDS YP_006780932.1 407483783 13703514 complement(4405448..4406218) 1 NC_018658.1 COG2086 Electron transfer flavoprotein, beta subunit; putative electron transfer flavoprotein FixA 4406218 13703514 O3K_21340 Escherichia coli O104:H4 str. 2011C-3493 putative electron transfer flavoprotein FixA YP_006780932.1 4405448 R 1133852 CDS YP_006780933.1 407483784 13703515 4406692..4408206 1 NC_018658.1 COG1292 Choline-glycine betaine transporter; L-carnitine/gamma-butyrobetaine antiporter 4408206 13703515 O3K_21345 Escherichia coli O104:H4 str. 2011C-3493 L-carnitine/gamma-butyrobetaine antiporter YP_006780933.1 4406692 D 1133852 CDS YP_006780934.1 407483785 13703516 4408237..4409379 1 NC_018658.1 COG1960 Acyl-CoA dehydrogenases; crotonobetainyl-CoA dehydrogenase 4409379 13703516 O3K_21350 Escherichia coli O104:H4 str. 2011C-3493 crotonobetainyl-CoA dehydrogenase YP_006780934.1 4408237 D 1133852 CDS YP_006780935.1 407483786 13703517 4409508..4410725 1 NC_018658.1 COG1804 Predicted acyl-CoA transferases/carnitine dehydratase; crotonobetainyl-CoA:carnitine CoA-transferase 4410725 13703517 O3K_21355 Escherichia coli O104:H4 str. 2011C-3493 crotonobetainyl-CoA:carnitine CoA-transferase YP_006780935.1 4409508 D 1133852 CDS YP_006780936.1 407483787 13703518 4410799..4412352 1 NC_018658.1 COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II; putative crotonobetaine/carnitine-CoA ligase 4412352 caiC 13703518 caiC Escherichia coli O104:H4 str. 2011C-3493 putative crotonobetaine/carnitine-CoA ligase YP_006780936.1 4410799 D 1133852 CDS YP_006780937.1 407483788 13703519 4412461..4413246 1 NC_018658.1 COG1024 Enoyl-CoA hydratase/carnithine racemase; carnitinyl-CoA dehydratase 4413246 13703519 O3K_21365 Escherichia coli O104:H4 str. 2011C-3493 carnitinyl-CoA dehydratase YP_006780937.1 4412461 D 1133852 CDS YP_006780938.1 407483789 13703520 4413252..4413842 1 NC_018658.1 COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily; carnitine operon protein CaiE 4413842 13703520 O3K_21370 Escherichia coli O104:H4 str. 2011C-3493 carnitine operon protein CaiE YP_006780938.1 4413252 D 1133852 CDS YP_006780939.1 407483790 13703521 complement(4413928..4414323) 1 NC_018658.1 DNA-binding transcriptional activator CaiF 4414323 13703521 O3K_21375 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional activator CaiF YP_006780939.1 4413928 R 1133852 CDS YP_006780940.1 407483791 13703522 complement(4414584..4417805) 1 NC_018658.1 COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); carbamoyl phosphate synthase large subunit 4417805 carB 13703522 carB Escherichia coli O104:H4 str. 2011C-3493 carbamoyl phosphate synthase large subunit YP_006780940.1 4414584 R 1133852 CDS YP_006780941.1 407483792 13703523 complement(4417823..4418971) 1 NC_018658.1 COG0505 Carbamoylphosphate synthase small subunit; carbamoyl phosphate synthase small subunit 4418971 13703523 O3K_21385 Escherichia coli O104:H4 str. 2011C-3493 carbamoyl phosphate synthase small subunit YP_006780941.1 4417823 R 1133852 CDS YP_006780942.1 407483793 13703524 4419089..4419184 1 NC_018658.1 hypothetical protein 4419184 13703524 O3K_21390 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780942.1 4419089 D 1133852 CDS YP_006780943.1 407483794 13703525 complement(4419427..4420248) 1 NC_018658.1 COG0289 Dihydrodipicolinate reductase; dihydrodipicolinate reductase 4420248 13703525 O3K_21395 Escherichia coli O104:H4 str. 2011C-3493 dihydrodipicolinate reductase YP_006780943.1 4419427 R 1133852 CDS YP_006780944.1 407483795 13703526 complement(4420415..4421329) 1 NC_018658.1 COG1957 Inosine-uridine nucleoside N-ribohydrolase; ribonucleoside hydrolase RihC 4421329 13703526 O3K_21400 Escherichia coli O104:H4 str. 2011C-3493 ribonucleoside hydrolase RihC YP_006780944.1 4420415 R 1133852 CDS YP_006780945.1 407483796 13703527 complement(4421395..4422345) 1 NC_018658.1 COG0761 Penicillin tolerance protein; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 4422345 ispH 13703527 ispH Escherichia coli O104:H4 str. 2011C-3493 4-hydroxy-3-methylbut-2-enyl diphosphate reductase YP_006780945.1 4421395 R 1133852 CDS YP_006780946.1 407483797 13703528 complement(4422347..4422796) 1 NC_018658.1 COG1047 FKBP-type peptidyl-prolyl cis-trans isomerases 2; FKBP-type peptidyl-prolyl cis-trans isomerase 4422796 13703528 O3K_21410 Escherichia coli O104:H4 str. 2011C-3493 FKBP-type peptidyl-prolyl cis-trans isomerase YP_006780946.1 4422347 R 1133852 CDS YP_006780947.1 407483798 13703529 complement(4422884..4423378) 1 NC_018658.1 COG0597 Lipoprotein signal peptidase; lipoprotein signal peptidase 4423378 lspA 13703529 lspA Escherichia coli O104:H4 str. 2011C-3493 lipoprotein signal peptidase YP_006780947.1 4422884 R 1133852 CDS YP_006780948.1 407483799 13703530 complement(4423378..4426194) 1 NC_018658.1 COG0060 Isoleucyl-tRNA synthetase; isoleucyl-tRNA synthetase 4426194 ileS 13703530 ileS Escherichia coli O104:H4 str. 2011C-3493 isoleucyl-tRNA synthetase YP_006780948.1 4423378 R 1133852 CDS YP_006780949.1 407483800 13703531 complement(4426237..4427178) 1 NC_018658.1 COG0196 FAD synthase; bifunctional riboflavin kinase/FMN adenylyltransferase 4427178 13703531 O3K_21425 Escherichia coli O104:H4 str. 2011C-3493 bifunctional riboflavin kinase/FMN adenylyltransferase YP_006780949.1 4426237 R 1133852 CDS YP_006780950.1 407483801 13703532 complement(4427186..4427404) 1 NC_018658.1 hypothetical protein 4427404 13703532 O3K_21430 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780950.1 4427186 R 1133852 CDS YP_006780951.1 407483802 13703533 4427507..4427770 1 NC_018658.1 COG0268 Ribosomal protein S20; 30S ribosomal protein S20 4427770 rpsT 13703533 rpsT Escherichia coli O104:H4 str. 2011C-3493 30S ribosomal protein S20 YP_006780951.1 4427507 D 1133852 CDS YP_006780952.1 407483803 13703534 4428553..4429674 1 NC_018658.1 COG1357 Uncharacterized low-complexity proteins; T3SS effector EspX 4429674 13703534 O3K_21440 Escherichia coli O104:H4 str. 2011C-3493 T3SS effector EspX YP_006780952.1 4428553 D 1133852 CDS YP_006780953.1 407483804 13703535 4430107..4431252 1 NC_018658.1 COG3188 P pilus assembly protein, porin PapC; hypothetical protein 4431252 13703535 O3K_21445 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780953.1 4430107 D 1133852 CDS YP_006780954.1 407483805 13703536 4431265..4432224 1 NC_018658.1 hypothetical protein 4432224 13703536 O3K_21450 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780954.1 4431265 D 1133852 CDS YP_006780955.1 407483806 13703537 complement(4432263..4433168) 1 NC_018658.1 COG0583 Transcriptional regulator; transcriptional activator NhaR 4433168 nhaR 13703537 nhaR Escherichia coli O104:H4 str. 2011C-3493 transcriptional activator NhaR YP_006780955.1 4432263 R 1133852 CDS YP_006780956.1 407483807 13703538 complement(4433228..4434394) 1 NC_018658.1 COG3004 Na+/H+ antiporter; pH-dependent sodium/proton antiporter 4434394 nhaA 13703538 nhaA Escherichia coli O104:H4 str. 2011C-3493 pH-dependent sodium/proton antiporter YP_006780956.1 4433228 R 1133852 CDS YP_006780957.1 407483808 13703539 4434923..4435132 1 NC_018658.1 regulatory protein MokC for HokC 4435132 13703539 O3K_21465 Escherichia coli O104:H4 str. 2011C-3493 regulatory protein MokC for HokC YP_006780957.1 4434923 D 1133852 CDS YP_006780958.1 407483809 13703540 complement(4435236..4436366) 1 NC_018658.1 COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain; chaperone protein DnaJ 4436366 13703540 O3K_21470 Escherichia coli O104:H4 str. 2011C-3493 chaperone protein DnaJ YP_006780958.1 4435236 R 1133852 CDS YP_006780959.1 407483810 13703541 complement(4436455..4438371) 1 NC_018658.1 COG0443 Molecular chaperone; molecular chaperone DnaK 4438371 dnaK 13703541 dnaK Escherichia coli O104:H4 str. 2011C-3493 molecular chaperone DnaK YP_006780959.1 4436455 R 1133852 CDS YP_006780960.1 407483811 13703542 4438748..4439152 1 NC_018658.1 hypothetical protein 4439152 13703542 O3K_21480 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780960.1 4438748 D 1133852 CDS YP_006780961.1 407483812 13703543 4439178..4439891 1 NC_018658.1 COG4735 Uncharacterized protein conserved in bacteria; hypothetical protein 4439891 13703543 O3K_21485 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780961.1 4439178 D 1133852 CDS YP_006780962.1 407483813 13703544 4440040..4440606 1 NC_018658.1 COG1584 Predicted membrane protein; hypothetical protein 4440606 13703544 O3K_21490 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780962.1 4440040 D 1133852 CDS YP_006780963.1 407483814 13703545 complement(4440641..4441228) 1 NC_018658.1 COG0521 Molybdopterin biosynthesis enzymes; molybdenum cofactor biosynthesis protein MogA 4441228 mogA 13703545 mogA Escherichia coli O104:H4 str. 2011C-3493 molybdenum cofactor biosynthesis protein MogA YP_006780963.1 4440641 R 1133852 CDS YP_006780964.1 407483815 13703546 complement(4441343..4442296) 1 NC_018658.1 COG0176 Transaldolase; transaldolase B 4442296 13703546 O3K_21500 Escherichia coli O104:H4 str. 2011C-3493 transaldolase B YP_006780964.1 4441343 R 1133852 CDS YP_006780965.1 407483816 13703547 4442575..4444005 1 NC_018658.1 COG1115 Na+/alanine symporter; transporter 4444005 13703547 O3K_21505 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006780965.1 4442575 D 1133852 CDS YP_006780966.1 407483817 13703548 4444075..4444851 1 NC_018658.1 COG3022 Uncharacterized protein conserved in bacteria; hypothetical protein 4444851 13703548 O3K_21510 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780966.1 4444075 D 1133852 CDS YP_006780967.1 407483818 13703549 complement(4445005..4445301) 1 NC_018658.1 hypothetical protein 4445301 13703549 O3K_21515 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780967.1 4445005 R 1133852 CDS YP_006780968.1 407483819 13703550 complement(4445515..4446801) 1 NC_018658.1 COG0498 Threonine synthase; threonine synthase 4446801 13703550 O3K_21520 Escherichia coli O104:H4 str. 2011C-3493 threonine synthase YP_006780968.1 4445515 R 1133852 CDS YP_006780969.1 407483820 13703551 complement(4446802..4447734) 1 NC_018658.1 COG0083 Homoserine kinase; homoserine kinase 4447734 13703551 O3K_21525 Escherichia coli O104:H4 str. 2011C-3493 homoserine kinase YP_006780969.1 4446802 R 1133852 CDS YP_006780970.1 407483821 13703552 complement(4447736..4450198) 1 NC_018658.1 COG0527 Aspartokinases; bifunctional aspartokinase I/homoserine dehydrogenase I 4450198 thrA 13703552 thrA Escherichia coli O104:H4 str. 2011C-3493 bifunctional aspartokinase I/homoserine dehydrogenase I YP_006780970.1 4447736 R 1133852 CDS YP_006780971.1 407483822 13703553 complement(4450558..4451244) 1 NC_018658.1 COG0565 rRNA methylase; putative RNA methyltransferase 4451244 13703553 O3K_21535 Escherichia coli O104:H4 str. 2011C-3493 putative RNA methyltransferase YP_006780971.1 4450558 R 1133852 CDS YP_006780972.1 407483823 13703554 4451880..4452596 1 NC_018658.1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; two-component response regulator 4452596 13703554 O3K_21540 Escherichia coli O104:H4 str. 2011C-3493 two-component response regulator YP_006780972.1 4451880 D 1133852 CDS YP_006780973.1 407483824 13703555 complement(4452656..4454008) 1 NC_018658.1 COG4452 Inner membrane protein involved in colicin E2 resistance; inner membrane protein 4454008 13703555 O3K_21545 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006780973.1 4452656 R 1133852 CDS YP_006780974.1 407483825 13703556 complement(4454066..4455490) 1 NC_018658.1 COG0642 Signal transduction histidine kinase; sensory histidine kinase CreC 4455490 13703556 O3K_21550 Escherichia coli O104:H4 str. 2011C-3493 sensory histidine kinase CreC YP_006780974.1 4454066 R 1133852 CDS YP_006780975.1 407483826 13703557 complement(4455490..4456179) 1 NC_018658.1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; DNA-binding response regulator CreB 4456179 13703557 O3K_21555 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding response regulator CreB YP_006780975.1 4455490 R 1133852 CDS YP_006780976.1 407483827 13703558 complement(4456192..4456665) 1 NC_018658.1 COG3045 Uncharacterized protein conserved in bacteria; hypothetical protein 4456665 13703558 O3K_21560 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780976.1 4456192 R 1133852 CDS YP_006780977.1 407483828 13703559 4456876..4457745 1 NC_018658.1 COG2207 AraC-type DNA-binding domain-containing proteins; right oriC-binding transcriptional activator 4457745 13703559 O3K_21565 Escherichia coli O104:H4 str. 2011C-3493 right oriC-binding transcriptional activator YP_006780977.1 4456876 D 1133852 CDS YP_006780978.1 407483829 13703560 complement(4457742..4458389) 1 NC_018658.1 COG0406 Fructose-2,6-bisphosphatase; phosphoglycerate mutase 4458389 13703560 O3K_21570 Escherichia coli O104:H4 str. 2011C-3493 phosphoglycerate mutase YP_006780978.1 4457742 R 1133852 CDS YP_006780979.1 407483830 13703561 4458441..4458953 1 NC_018658.1 COG1986 Uncharacterized conserved protein; inosine/xanthosine triphosphatase 4458953 13703561 O3K_21575 Escherichia coli O104:H4 str. 2011C-3493 inosine/xanthosine triphosphatase YP_006780979.1 4458441 D 1133852 CDS YP_006780980.1 407483831 13703562 complement(4458995..4459321) 1 NC_018658.1 COG2973 Trp operon repressor; Trp operon repressor 4459321 13703562 O3K_21580 Escherichia coli O104:H4 str. 2011C-3493 Trp operon repressor YP_006780980.1 4458995 R 1133852 CDS YP_006780981.1 407483832 13703563 complement(4459411..4461348) 1 NC_018658.1 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains); lytic murein transglycosylase 4461348 13703563 O3K_21585 Escherichia coli O104:H4 str. 2011C-3493 lytic murein transglycosylase YP_006780981.1 4459411 R 1133852 CDS YP_006780982.1 407483833 13703564 4461559..4463226 1 NC_018658.1 COG0488 ATPase components of ABC transporters with duplicated ATPase domains; ABC transporter ATP-binding protein 4463226 13703564 O3K_21590 Escherichia coli O104:H4 str. 2011C-3493 ABC transporter ATP-binding protein YP_006780982.1 4461559 D 1133852 CDS YP_006780983.1 407483834 13703565 complement(4463533..4464765) 1 NC_018658.1 COG1396 Predicted transcriptional regulators; bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase 4464765 13703565 O3K_21595 Escherichia coli O104:H4 str. 2011C-3493 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase YP_006780983.1 4463533 R 1133852 CDS YP_006780984.1 407483835 13703566 complement(4464786..4466168) 1 NC_018658.1 COG1066 Predicted ATP-dependent serine protease; DNA repair protein RadA 4466168 13703566 O3K_21600 Escherichia coli O104:H4 str. 2011C-3493 DNA repair protein RadA YP_006780984.1 4464786 R 1133852 CDS YP_006780985.1 407483836 13703567 complement(4466217..4467185) 1 NC_018658.1 COG0560 Phosphoserine phosphatase; phosphoserine phosphatase 4467185 serB 13703567 serB Escherichia coli O104:H4 str. 2011C-3493 phosphoserine phosphatase YP_006780985.1 4466217 R 1133852 CDS YP_006780986.1 407483837 13703568 4467291..4467935 1 NC_018658.1 COG3726 Uncharacterized membrane protein affecting hemolysin expression; hypothetical protein 4467935 13703568 O3K_21610 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780986.1 4467291 D 1133852 CDS YP_006780987.1 407483838 13703569 4467963..4468979 1 NC_018658.1 COG0095 Lipoate-protein ligase A; lipoate-protein ligase A 4468979 lplA 13703569 lplA Escherichia coli O104:H4 str. 2011C-3493 lipoate-protein ligase A YP_006780987.1 4467963 D 1133852 CDS YP_006780988.1 407483839 13703570 4469011..4469160 1 NC_018658.1 hypothetical protein 4469160 13703570 O3K_21620 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780988.1 4469011 D 1133852 CDS YP_006780989.1 407483840 13703571 complement(4469435..4470154) 1 NC_018658.1 COG0813 Purine-nucleoside phosphorylase; purine nucleoside phosphorylase 4470154 deoD 13703571 deoD Escherichia coli O104:H4 str. 2011C-3493 purine nucleoside phosphorylase YP_006780989.1 4469435 R 1133852 CDS YP_006780990.1 407483841 13703572 complement(4470234..4471457) 1 NC_018658.1 COG1015 Phosphopentomutase; phosphopentomutase 4471457 13703572 O3K_21630 Escherichia coli O104:H4 str. 2011C-3493 phosphopentomutase YP_006780990.1 4470234 R 1133852 CDS YP_006780991.1 407483842 13703573 complement(4471509..4472831) 1 NC_018658.1 COG0213 Thymidine phosphorylase; thymidine phosphorylase 4472831 deoA 13703573 deoA Escherichia coli O104:H4 str. 2011C-3493 thymidine phosphorylase YP_006780991.1 4471509 R 1133852 CDS YP_006780992.1 407483843 13703574 complement(4472909..4473688) 1 NC_018658.1 COG0274 Deoxyribose-phosphate aldolase; deoxyribose-phosphate aldolase 4473688 13703574 O3K_21640 Escherichia coli O104:H4 str. 2011C-3493 deoxyribose-phosphate aldolase YP_006780992.1 4472909 R 1133852 CDS YP_006780993.1 407483844 13703575 4473946..4475496 1 NC_018658.1 hypothetical protein 4475496 13703575 O3K_21645 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780993.1 4473946 D 1133852 CDS YP_006780994.1 407483845 13703576 4475468..4476331 1 NC_018658.1 COG1180 Pyruvate-formate lyase-activating enzyme; putative pyruvate formate lyase activating enzyme 4476331 13703576 O3K_21650 Escherichia coli O104:H4 str. 2011C-3493 putative pyruvate formate lyase activating enzyme YP_006780994.1 4475468 D 1133852 CDS YP_006780995.1 407483846 13703577 complement(4476561..4477343) 1 NC_018658.1 COG0084 Mg-dependent DNase; putative deoxyribonuclease YjjV 4477343 13703577 O3K_21655 Escherichia coli O104:H4 str. 2011C-3493 putative deoxyribonuclease YjjV YP_006780995.1 4476561 R 1133852 CDS YP_006780996.1 407483847 13703578 complement(4477340..4478413) 1 NC_018658.1 COG4667 Predicted esterase of the alpha-beta hydrolase superfamily; esterase 4478413 13703578 O3K_21660 Escherichia coli O104:H4 str. 2011C-3493 esterase YP_006780996.1 4477340 R 1133852 CDS YP_006780997.1 407483848 13703579 complement(4478535..4478696) 1 NC_018658.1 hypothetical protein 4478696 13703579 O3K_21665 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780997.1 4478535 R 1133852 CDS YP_006780998.1 407483849 13703580 complement(4478823..4479428) 1 NC_018658.1 COG2823 Predicted periplasmic or secreted lipoprotein; hypothetical protein 4479428 13703580 O3K_21670 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006780998.1 4478823 R 1133852 CDS YP_006780999.1 407483850 13703581 complement(4479821..4481410) 1 NC_018658.1 COG4108 Peptide chain release factor RF-3; peptide chain release factor 3 4481410 prfC 13703581 prfC Escherichia coli O104:H4 str. 2011C-3493 peptide chain release factor 3 YP_006780999.1 4479821 R 1133852 CDS YP_006781000.1 407483851 13703582 complement(4481501..4482178) 1 NC_018658.1 COG1011 Predicted hydrolase (HAD superfamily); dUMP phosphatase 4482178 13703582 O3K_21680 Escherichia coli O104:H4 str. 2011C-3493 dUMP phosphatase YP_006781000.1 4481501 R 1133852 CDS YP_006781001.1 407483852 13703583 complement(4482193..4482639) 1 NC_018658.1 COG0456 Acetyltransferases; ribosomal-protein-alanine N-acetyltransferase 4482639 rimI 13703583 rimI Escherichia coli O104:H4 str. 2011C-3493 ribosomal-protein-alanine N-acetyltransferase YP_006781001.1 4482193 R 1133852 CDS YP_006781002.1 407483853 13703584 complement(4482608..4483021) 1 NC_018658.1 COG3050 DNA polymerase III, psi subunit; DNA polymerase III subunit psi 4483021 13703584 O3K_21690 Escherichia coli O104:H4 str. 2011C-3493 DNA polymerase III subunit psi YP_006781002.1 4482608 R 1133852 CDS YP_006781003.1 407483854 13703585 4483124..4484155 1 NC_018658.1 COG2813 16S RNA G1207 methylase RsmC; 16S ribosomal RNA m2G1207 methyltransferase 4484155 rsmC 13703585 rsmC Escherichia coli O104:H4 str. 2011C-3493 16S ribosomal RNA m2G1207 methyltransferase YP_006781003.1 4483124 D 1133852 CDS YP_006781004.1 407483855 13703589 complement(4484825..4485061) 1 NC_018658.1 hypothetical protein 4485061 13703589 O3K_21700 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781004.1 4484825 R 1133852 CDS YP_006781005.1 407483856 13703590 4485202..4485990 1 NC_018658.1 COG4114 Uncharacterized Fe-S protein; ferric hydroximate transport ferric iron reductase 4485990 13703590 O3K_21705 Escherichia coli O104:H4 str. 2011C-3493 ferric hydroximate transport ferric iron reductase YP_006781005.1 4485202 D 1133852 CDS YP_006781006.1 407483857 13703591 complement(4486028..4486651) 1 NC_018658.1 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; DNA-binding transcriptional activator BglJ 4486651 13703591 O3K_21710 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional activator BglJ YP_006781006.1 4486028 R 1133852 CDS YP_006781007.1 407483858 13703592 complement(4486663..4487388) 1 NC_018658.1 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; DNA-binding transcriptional regulator 4487388 13703592 O3K_21715 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator YP_006781007.1 4486663 R 1133852 CDS YP_006781008.1 407483859 13703593 4488009..4488779 1 NC_018658.1 COG2966 Uncharacterized conserved protein; hypothetical protein 4488779 13703593 O3K_21720 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781008.1 4488009 D 1133852 CDS YP_006781009.1 407483860 13703594 4488770..4489243 1 NC_018658.1 COG3610 Uncharacterized conserved protein; hypothetical protein 4489243 13703594 O3K_21725 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781009.1 4488770 D 1133852 CDS YP_006781010.1 407483861 13703595 4489350..4489889 1 NC_018658.1 primosomal protein DnaI 4489889 13703595 O3K_21730 Escherichia coli O104:H4 str. 2011C-3493 primosomal protein DnaI YP_006781010.1 4489350 D 1133852 CDS YP_006781011.1 407483862 13703596 4489892..4490629 1 NC_018658.1 COG1484 DNA replication protein; DNA replication protein DnaC 4490629 13703596 O3K_21735 Escherichia coli O104:H4 str. 2011C-3493 DNA replication protein DnaC YP_006781011.1 4489892 D 1133852 CDS YP_006781012.1 407483863 13703597 4490675..4491172 1 NC_018658.1 hypothetical protein 4491172 13703597 O3K_21740 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781012.1 4490675 D 1133852 CDS YP_006781013.1 407483864 13703598 4491426..4493717 1 NC_018658.1 COG1368 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily; phosphoglycerol transferase I 4493717 13703598 O3K_21745 Escherichia coli O104:H4 str. 2011C-3493 phosphoglycerol transferase I YP_006781013.1 4491426 D 1133852 CDS YP_006781014.1 407483865 13703599 complement(4493858..4494880) 1 NC_018658.1 COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases; oxidoreductase, Zn-dependent and NAD(P)-binding protein 4494880 13703599 O3K_21750 Escherichia coli O104:H4 str. 2011C-3493 oxidoreductase, Zn-dependent and NAD(P)-binding protein YP_006781014.1 4493858 R 1133852 CDS YP_006781015.1 407483866 13703600 4495019..4495933 1 NC_018658.1 COG1802 Transcriptional regulators; GntR family transcriptional regulator 4495933 13703600 O3K_21755 Escherichia coli O104:H4 str. 2011C-3493 GntR family transcriptional regulator YP_006781015.1 4495019 D 1133852 CDS YP_006781016.1 407483867 13703601 4496148..4497509 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; transporter 4497509 13703601 O3K_21760 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006781016.1 4496148 D 1133852 CDS YP_006781017.1 407483868 13703602 complement(4497558..4499222) 1 NC_018658.1 COG0840 Methyl-accepting chemotaxis protein; methyl-accepting chemotaxis protein I 4499222 13703602 O3K_21765 Escherichia coli O104:H4 str. 2011C-3493 methyl-accepting chemotaxis protein I YP_006781017.1 4497558 R 1133852 CDS YP_006781018.1 407483869 13703603 4499599..4501749 1 NC_018658.1 COG1966 Carbon starvation protein, predicted membrane protein; inner membrane protein 4501749 13703603 O3K_21770 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006781018.1 4499599 D 1133852 CDS YP_006781019.1 407483870 13703604 4501880..4502083 1 NC_018658.1 COG2879 Uncharacterized small protein; hypothetical protein 4502083 13703604 O3K_21775 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781019.1 4501880 D 1133852 CDS YP_006781020.1 407483871 13703605 4502094..4503050 1 NC_018658.1 COG0523 Putative GTPases (G3E family); putative GTP-binding protein YjiA 4503050 13703605 O3K_21780 Escherichia coli O104:H4 str. 2011C-3493 putative GTP-binding protein YjiA YP_006781020.1 4502094 D 1133852 CDS YP_006781021.1 407483872 13703606 complement(4503119..4504771) 1 NC_018658.1 COG1479 Uncharacterized conserved protein; hypothetical protein 4504771 13703606 O3K_21785 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781021.1 4503119 R 1133852 CDS YP_006781022.1 407483873 13703607 4505049..4507481 1 NC_018658.1 COG4096 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases; Type I restriction enzyme EcoAI R protein (R.EcoAI) 4507481 13703607 O3K_21790 Escherichia coli O104:H4 str. 2011C-3493 Type I restriction enzyme EcoAI R protein (R.EcoAI) YP_006781022.1 4505049 D 1133852 CDS YP_006781023.1 407483874 13703608 4507548..4509017 1 NC_018658.1 COG0286 Type I restriction-modification system methyltransferase subunit; Type I restriction enzyme EcoEI M protein (M.EcoEI) 4509017 13703608 O3K_21795 Escherichia coli O104:H4 str. 2011C-3493 Type I restriction enzyme EcoEI M protein (M.EcoEI) YP_006781023.1 4507548 D 1133852 CDS YP_006781024.1 407483875 13703609 4509017..4510753 1 NC_018658.1 COG0732 Restriction endonuclease S subunits; Type I restriction enzyme EcoAI specificity protein (S protein, S.EcoAI) 4510753 13703609 O3K_21800 Escherichia coli O104:H4 str. 2011C-3493 Type I restriction enzyme EcoAI specificity protein (S protein, S.EcoAI) YP_006781024.1 4509017 D 1133852 CDS YP_006781025.1 407483876 13703610 4510974..4511315 1 NC_018658.1 endoribonuclease SymE 4511315 13703610 O3K_21805 Escherichia coli O104:H4 str. 2011C-3493 endoribonuclease SymE YP_006781025.1 4510974 D 1133852 CDS YP_006781026.1 407483877 13703611 complement(4513552..4513716) 1 NC_018658.1 hypothetical protein 4513716 13703611 O3K_21820 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781026.1 4513552 R 1133852 CDS YP_006781027.1 407483878 13703612 4513893..4515305 1 NC_018658.1 COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs; DNA-binding transcriptional regulator/aminotransferase 4515305 13703612 O3K_21825 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator/aminotransferase YP_006781027.1 4513893 D 1133852 CDS YP_006781028.1 407483879 13703613 complement(4515548..4516504) 1 NC_018658.1 transposase 4516504 13703613 O3K_21830 Escherichia coli O104:H4 str. 2011C-3493 transposase YP_006781028.1 4515548 R 1133852 CDS YP_006781029.1 407483880 13703614 4516971..4518203 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; multidrug efflux system protein MdtM 4518203 13703614 O3K_21835 Escherichia coli O104:H4 str. 2011C-3493 multidrug efflux system protein MdtM YP_006781029.1 4516971 D 1133852 CDS YP_006781030.1 407483881 13703615 4518277..4519524 1 NC_018658.1 COG2733 Predicted membrane protein; inner membrane protein 4519524 13703615 O3K_21840 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006781030.1 4518277 D 1133852 CDS YP_006781031.1 407483882 13703616 4519640..4520791 1 NC_018658.1 COG1775 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB; putative 2-hydroxyglutaryl-CoA dehydratase 4520791 13703616 O3K_21845 Escherichia coli O104:H4 str. 2011C-3493 putative 2-hydroxyglutaryl-CoA dehydratase YP_006781031.1 4519640 D 1133852 CDS YP_006781032.1 407483883 13703617 4520801..4521568 1 NC_018658.1 COG1924 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain); hypothetical protein 4521568 13703617 O3K_21850 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781032.1 4520801 D 1133852 CDS YP_006781033.1 407483884 13703618 4521565..4521822 1 NC_018658.1 hypothetical protein 4521822 13703618 O3K_21855 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781033.1 4521565 D 1133852 CDS YP_006781034.1 407483885 13703619 4521776..4522747 1 NC_018658.1 COG3204 Uncharacterized protein conserved in bacteria; hypothetical protein 4522747 13703619 O3K_21860 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781034.1 4521776 D 1133852 CDS YP_006781035.1 407483886 13703620 4522815..4523993 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; inner membrane protein 4523993 13703620 O3K_21865 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006781035.1 4522815 D 1133852 CDS YP_006781036.1 407483887 13703621 complement(4524006..4524560) 1 NC_018658.1 COG1859 RNA:NAD 2'-phosphotransferase; RNA 2'-phosphotransferase 4524560 13703621 O3K_21870 Escherichia coli O104:H4 str. 2011C-3493 RNA 2'-phosphotransferase YP_006781036.1 4524006 R 1133852 CDS YP_006781037.1 407483888 13703622 4524810..4525493 1 NC_018658.1 COG3314 Uncharacterized protein conserved in bacteria; hypothetical protein 4525493 13703622 O3K_21875 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781037.1 4524810 D 1133852 CDS YP_006781038.1 407483889 13703623 4525490..4525951 1 NC_018658.1 COG0700 Uncharacterized membrane protein; hypothetical protein 4525951 13703623 O3K_21880 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781038.1 4525490 D 1133852 CDS YP_006781039.1 407483890 13703624 4525964..4527136 1 NC_018658.1 COG0044 Dihydroorotase and related cyclic amidohydrolases; isoaspartyl dipeptidase 4527136 13703624 O3K_21885 Escherichia coli O104:H4 str. 2011C-3493 isoaspartyl dipeptidase YP_006781039.1 4525964 D 1133852 CDS YP_006781040.1 407483891 13703625 4527201..4528112 1 NC_018658.1 COG0583 Transcriptional regulator; cell density-dependent motility repressor 4528112 13703625 O3K_21890 Escherichia coli O104:H4 str. 2011C-3493 cell density-dependent motility repressor YP_006781040.1 4527201 D 1133852 CDS YP_006781041.1 407483892 13703626 complement(4528105..4528497) 1 NC_018658.1 DNA replication/recombination/repair protein 4528497 iraD 13703626 iraD Escherichia coli O104:H4 str. 2011C-3493 DNA replication/recombination/repair protein YP_006781041.1 4528105 R 1133852 CDS YP_006781042.1 407483893 13703627 4529169..4529999 1 NC_018658.1 hypothetical protein 4529999 13703627 O3K_21900 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781042.1 4529169 D 1133852 CDS YP_006781043.1 407483894 13703628 complement(4530140..4530913) 1 NC_018658.1 COG2186 Transcriptional regulators; DNA-binding transcriptional repressor UxuR 4530913 13703628 O3K_21905 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional repressor UxuR YP_006781043.1 4530140 R 1133852 CDS YP_006781044.1 407483895 13703629 4530912..4531106 1 NC_018658.1 hypothetical protein 4531106 13703629 O3K_21910 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781044.1 4530912 D 1133852 CDS YP_006781045.1 407483896 13703630 complement(4531128..4532588) 1 NC_018658.1 COG0246 Mannitol-1-phosphate/altronate dehydrogenases; D-mannonate oxidoreductase 4532588 13703630 O3K_21915 Escherichia coli O104:H4 str. 2011C-3493 D-mannonate oxidoreductase YP_006781045.1 4531128 R 1133852 CDS YP_006781046.1 407483897 13703631 complement(4532669..4533853) 1 NC_018658.1 COG1312 D-mannonate dehydratase; mannonate dehydratase 4533853 13703631 O3K_21920 Escherichia coli O104:H4 str. 2011C-3493 mannonate dehydratase YP_006781046.1 4532669 R 1133852 CDS YP_006781047.1 407483898 13703632 4534193..4535536 1 NC_018658.1 COG2610 H+/gluconate symporter and related permeases; fructuronate transporter 4535536 13703632 O3K_21925 Escherichia coli O104:H4 str. 2011C-3493 fructuronate transporter YP_006781047.1 4534193 D 1133852 CDS YP_006781048.1 407483899 13703633 4535935..4536210 1 NC_018658.1 COG3677 Transposase and inactivated derivatives; IS1 repressor protein insA 4536210 13703633 O3K_21930 Escherichia coli O104:H4 str. 2011C-3493 IS1 repressor protein insA YP_006781048.1 4535935 D 1133852 CDS YP_006781049.1 407483900 13703634 4536129..4536632 1 NC_018658.1 COG1662 Transposase and inactivated derivatives, IS1 family; putative IS1 transposase InsAB' 4536632 13703634 O3K_21935 Escherichia coli O104:H4 str. 2011C-3493 putative IS1 transposase InsAB' YP_006781049.1 4536129 D 1133852 CDS YP_006781050.1 407483901 13703635 complement(4536643..4537320) 1 NC_018658.1 hypothetical protein 4537320 13703635 O3K_21940 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781050.1 4536643 R 1133852 CDS YP_006781051.1 407483902 13703636 complement(4538521..4539129) 1 NC_018658.1 COG1960 Acyl-CoA dehydrogenases; hypothetical protein 4539129 13703636 O3K_21945 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781051.1 4538521 R 1133852 CDS YP_006781052.1 407483903 13703637 complement(4539218..4539424) 1 NC_018658.1 COG3311 Predicted transcriptional regulator; hypothetical protein 4539424 13703637 O3K_21950 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781052.1 4539218 R 1133852 CDS YP_006781053.1 407483904 13703638 4539565..4539831 1 NC_018658.1 hypothetical protein 4539831 13703638 O3K_21955 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781053.1 4539565 D 1133852 CDS YP_006781054.1 407483905 13703639 4540132..4540308 1 NC_018658.1 hemolysin expression modulating protein Hha 4540308 13703639 O3K_21960 Escherichia coli O104:H4 str. 2011C-3493 hemolysin expression modulating protein Hha YP_006781054.1 4540132 D 1133852 CDS YP_006781055.1 407483906 13703640 4541049..4541618 1 NC_018658.1 hypothetical protein 4541618 13703640 O3K_21965 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781055.1 4541049 D 1133852 CDS YP_006781056.1 407483907 13703641 4541872..4542279 1 NC_018658.1 COG0085 DNA-directed RNA polymerase, beta subunit/140 kD subunit; hypothetical protein 4542279 13703641 O3K_21970 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781056.1 4541872 D 1133852 CDS YP_006781057.1 407483908 13703642 4542267..4542701 1 NC_018658.1 hypothetical protein 4542701 13703642 O3K_21975 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781057.1 4542267 D 1133852 CDS YP_006781058.1 407483909 13703643 4543035..4543436 1 NC_018658.1 COG2963 Transposase and inactivated derivatives; transposase, IS3 family protein 4543436 13703643 O3K_21980 Escherichia coli O104:H4 str. 2011C-3493 transposase, IS3 family protein YP_006781058.1 4543035 D 1133852 CDS YP_006781059.1 407483910 13703644 4543433..4543780 1 NC_018658.1 COG3436 Transposase and inactivated derivatives; transposase 4543780 13703644 O3K_21985 Escherichia coli O104:H4 str. 2011C-3493 transposase YP_006781059.1 4543433 D 1133852 CDS YP_006781060.1 407483911 13703645 4543830..4545215 1 NC_018658.1 COG3436 Transposase and inactivated derivatives; transposase 4545215 13703645 O3K_21990 Escherichia coli O104:H4 str. 2011C-3493 transposase YP_006781060.1 4543830 D 1133852 CDS YP_006781061.1 407483912 13703646 complement(4545454..4546812) 1 NC_018658.1 COG4222 Uncharacterized protein conserved in bacteria; hypothetical protein 4546812 13703646 O3K_21995 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781061.1 4545454 R 1133852 CDS YP_006781062.1 407483913 13703647 4547191..4547400 1 NC_018658.1 hypothetical protein 4547400 13703647 O3K_22000 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781062.1 4547191 D 1133852 CDS YP_006781063.1 407483914 13703648 complement(4547563..4547820) 1 NC_018658.1 hypothetical protein 4547820 13703648 O3K_22005 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781063.1 4547563 R 1133852 CDS YP_006781064.1 407483915 13703649 4548738..4549259 1 NC_018658.1 COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; RNA polymerase sigma factor FecI 4549259 13703649 O3K_22010 Escherichia coli O104:H4 str. 2011C-3493 RNA polymerase sigma factor FecI YP_006781064.1 4548738 D 1133852 CDS YP_006781065.1 407483916 13703650 4549256..4550209 1 NC_018658.1 COG3712 Fe2+-dicitrate sensor, membrane component; fec operon regulator FecR 4550209 13703650 O3K_22015 Escherichia coli O104:H4 str. 2011C-3493 fec operon regulator FecR YP_006781065.1 4549256 D 1133852 CDS YP_006781066.1 407483917 13703651 4550296..4552620 1 NC_018658.1 COG4772 Outer membrane receptor for Fe3+-dicitrate; ferric citrate outer membrane transporter, KpLE2 phage-like element 4552620 13703651 O3K_22020 Escherichia coli O104:H4 str. 2011C-3493 ferric citrate outer membrane transporter, KpLE2 phage-like element YP_006781066.1 4550296 D 1133852 CDS YP_006781067.1 407483918 13703652 4552665..4553567 1 NC_018658.1 COG4594 ABC-type Fe3+-citrate transport system, periplasmic component; iron-dicitrate transporter substrate-binding subunit 4553567 fecB 13703652 fecB Escherichia coli O104:H4 str. 2011C-3493 iron-dicitrate transporter substrate-binding subunit YP_006781067.1 4552665 D 1133852 CDS YP_006781068.1 407483919 13703653 4553564..4554562 1 NC_018658.1 COG0609 ABC-type Fe3+-siderophore transport system, permease component; iron-dicitrate transporter permease subunit 4554562 fecC 13703653 fecC Escherichia coli O104:H4 str. 2011C-3493 iron-dicitrate transporter permease subunit YP_006781068.1 4553564 D 1133852 CDS YP_006781069.1 407483920 13703654 4554559..4555515 1 NC_018658.1 COG0609 ABC-type Fe3+-siderophore transport system, permease component; iron-dicitrate transporter subunit FecD 4555515 fecD 13703654 fecD Escherichia coli O104:H4 str. 2011C-3493 iron-dicitrate transporter subunit FecD YP_006781069.1 4554559 D 1133852 CDS YP_006781070.1 407483921 13703655 4555516..4556283 1 NC_018658.1 COG1120 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components; iron-dicitrate transporter ATP-binding subunit 4556283 fecE 13703655 fecE Escherichia coli O104:H4 str. 2011C-3493 iron-dicitrate transporter ATP-binding subunit YP_006781070.1 4555516 D 1133852 CDS YP_006781071.1 407483922 13703656 complement(4556841..4557254) 1 NC_018658.1 COG2085 Predicted dinucleotide-binding enzymes; KpLE2 phage-like element 4557254 13703656 O3K_22045 Escherichia coli O104:H4 str. 2011C-3493 KpLE2 phage-like element YP_006781071.1 4556841 R 1133852 CDS YP_006781072.1 407483923 13703657 complement(4557749..4559272) 1 NC_018658.1 COG3344 Retron-type reverse transcriptase; putative group II intron encoded reverse transcriptase/maturase 4559272 13703657 O3K_22055 Escherichia coli O104:H4 str. 2011C-3493 putative group II intron encoded reverse transcriptase/maturase YP_006781072.1 4557749 R 1133852 CDS YP_006781073.1 407483924 13703658 complement(4560345..4560647) 1 NC_018658.1 COG2963 Transposase and inactivated derivatives; IS911; transposase ORF A, IS911 4560647 13703658 O3K_22065 Escherichia coli O104:H4 str. 2011C-3493 transposase ORF A, IS911 YP_006781073.1 4560345 R 1133852 CDS YP_006781074.1 407483925 13703659 4560854..4561675 1 NC_018658.1 COG0726 Predicted xylanase/chitin deacetylase; polysaccharide deacetylase family protein 4561675 13703659 O3K_22070 Escherichia coli O104:H4 str. 2011C-3493 polysaccharide deacetylase family protein YP_006781074.1 4560854 D 1133852 CDS YP_006781075.1 407483926 13703660 4561678..4562766 1 NC_018658.1 COG0438 Glycosyltransferase; Glycosyl transferase 4562766 13703660 O3K_22075 Escherichia coli O104:H4 str. 2011C-3493 Glycosyl transferase YP_006781075.1 4561678 D 1133852 CDS YP_006781076.1 407483927 13703661 4562771..4563721 1 NC_018658.1 COG2990 Uncharacterized protein conserved in bacteria; regulator of virG protein 4563721 13703661 O3K_22080 Escherichia coli O104:H4 str. 2011C-3493 regulator of virG protein YP_006781076.1 4562771 D 1133852 CDS YP_006781077.1 407483928 13703662 4563786..4564730 1 NC_018658.1 COG1560 Lauroyl/myristoyl acyltransferase; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase 4564730 13703662 O3K_22085 Escherichia coli O104:H4 str. 2011C-3493 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase YP_006781077.1 4563786 D 1133852 CDS YP_006781078.1 407483929 13703663 4565337..4566050 1 NC_018658.1 COG2801 Transposase and inactivated derivatives; hypothetical protein 4566050 13703663 O3K_22090 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781078.1 4565337 D 1133852 CDS YP_006781079.1 407483930 13703664 4566198..4568201 1 NC_018658.1 COG1292 Choline-glycine betaine transporter; betaine-carnitine-choline transporter family member BetU 4568201 13703664 O3K_22095 Escherichia coli O104:H4 str. 2011C-3493 betaine-carnitine-choline transporter family member BetU YP_006781079.1 4566198 D 1133852 CDS YP_006781080.1 407483931 13703665 4568264..4569541 1 NC_018658.1 COG4325 Predicted membrane protein; hypothetical protein 4569541 13703665 O3K_22100 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781080.1 4568264 D 1133852 CDS YP_006781081.1 407483932 13703666 4569787..4570443 1 NC_018658.1 COG1309 Transcriptional regulator; HTH regulator, TetR family protein 4570443 13703666 O3K_22105 Escherichia coli O104:H4 str. 2011C-3493 HTH regulator, TetR family protein YP_006781081.1 4569787 D 1133852 CDS YP_006781082.1 407483933 13703667 4570891..4571316 1 NC_018658.1 COG2963 Transposase and inactivated derivatives; IS66 transposase 4571316 13703667 O3K_22115 Escherichia coli O104:H4 str. 2011C-3493 IS66 transposase YP_006781082.1 4570891 D 1133852 CDS YP_006781083.1 407483934 13703668 4571313..4571663 1 NC_018658.1 COG3436 Transposase and inactivated derivatives; IS66 transposase 4571663 13703668 O3K_22120 Escherichia coli O104:H4 str. 2011C-3493 IS66 transposase YP_006781083.1 4571313 D 1133852 CDS YP_006781084.1 407483935 13703669 4571694..4573307 1 NC_018658.1 COG3436 Transposase and inactivated derivatives; putative IS element transposase 4573307 13703669 O3K_22125 Escherichia coli O104:H4 str. 2011C-3493 putative IS element transposase YP_006781084.1 4571694 D 1133852 CDS YP_006781085.1 407483936 13703670 complement(4573383..4573646) 1 NC_018658.1 hypothetical protein 4573646 13703670 O3K_22130 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781085.1 4573383 R 1133852 CDS YP_006781086.1 407483937 13703671 4574274..4574390 1 NC_018658.1 hypothetical protein 4574390 13703671 O3K_22135 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781086.1 4574274 D 1133852 CDS YP_006781087.1 407483938 13703672 4574391..4574489 1 NC_018658.1 acetolactate synthase 1 regulatory subunit 4574489 13703672 O3K_22140 Escherichia coli O104:H4 str. 2011C-3493 acetolactate synthase 1 regulatory subunit YP_006781087.1 4574391 D 1133852 CDS YP_006781088.1 407483939 13703673 complement(4574491..4575273) 1 NC_018658.1 COG1349 Transcriptional regulators of sugar metabolism; transcriptional regulator 4575273 13703673 O3K_22145 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator YP_006781088.1 4574491 R 1133852 CDS YP_006781089.1 407483940 13703674 4575579..4576499 1 NC_018658.1 COG0524 Sugar kinases, ribokinase family; ribokinase sugar kinase 4576499 13703674 O3K_22150 Escherichia coli O104:H4 str. 2011C-3493 ribokinase sugar kinase YP_006781089.1 4575579 D 1133852 CDS YP_006781090.1 407483941 13703675 4576527..4577843 1 NC_018658.1 COG0738 Fucose permease; L-fucose permease 4577843 13703675 O3K_22155 Escherichia coli O104:H4 str. 2011C-3493 L-fucose permease YP_006781090.1 4576527 D 1133852 CDS YP_006781091.1 407483942 13703676 4577855..4578868 1 NC_018658.1 Deoxyribose specific mutarotase 4578868 13703676 O3K_22160 Escherichia coli O104:H4 str. 2011C-3493 Deoxyribose specific mutarotase YP_006781091.1 4577855 D 1133852 CDS YP_006781092.1 407483943 13703677 complement(4579791..4581047) 1 NC_018658.1 COG3037 Uncharacterized protein conserved in bacteria; PTS system ascorbate-specific transporter subunit IIC 4581047 13703677 O3K_22170 Escherichia coli O104:H4 str. 2011C-3493 PTS system ascorbate-specific transporter subunit IIC YP_006781092.1 4579791 R 1133852 CDS YP_006781093.1 407483944 13703678 complement(4581060..4581347) 1 NC_018658.1 COG3414 Phosphotransferase system, galactitol-specific IIB component; PTS system transporter subunit IIB 4581347 13703678 O3K_22175 Escherichia coli O104:H4 str. 2011C-3493 PTS system transporter subunit IIB YP_006781093.1 4581060 R 1133852 CDS YP_006781094.1 407483945 13703679 complement(4581363..4581806) 1 NC_018658.1 COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type); PTS system transporter subunit IIA 4581806 13703679 O3K_22180 Escherichia coli O104:H4 str. 2011C-3493 PTS system transporter subunit IIA YP_006781094.1 4581363 R 1133852 CDS YP_006781095.1 407483946 13703680 4582077..4583108 1 NC_018658.1 COG1609 Transcriptional regulators; transcriptional regulator 4583108 13703680 O3K_22185 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator YP_006781095.1 4582077 D 1133852 CDS YP_006781096.1 407483947 13703681 complement(4584288..4584446) 1 NC_018658.1 COG0207 Thymidylate synthase; hypothetical protein 4584446 13703681 O3K_22195 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781096.1 4584288 R 1133852 CDS YP_006781097.1 407483948 13703682 4584598..4584870 1 NC_018658.1 hypothetical protein 4584870 13703682 O3K_22200 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781097.1 4584598 D 1133852 CDS YP_006781098.1 407483949 13703683 complement(4584878..4585099) 1 NC_018658.1 hypothetical protein 4585099 13703683 O3K_22205 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781098.1 4584878 R 1133852 CDS YP_006781099.1 407483950 13703684 complement(4585078..4585242) 1 NC_018658.1 hypothetical protein 4585242 13703684 O3K_22210 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781099.1 4585078 R 1133852 CDS YP_006781100.1 407483951 13703685 complement(4585354..4586043) 1 NC_018658.1 COG3010 Putative N-acetylmannosamine-6-phosphate epimerase; N-acetylmannosamine-6-phosphate 2-epimerase 4586043 13703685 O3K_22215 Escherichia coli O104:H4 str. 2011C-3493 N-acetylmannosamine-6-phosphate 2-epimerase YP_006781100.1 4585354 R 1133852 CDS YP_006781101.1 407483952 13703686 complement(4586043..4587599) 1 NC_018658.1 COG1263 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific; PTS system glucose-specific transporter subunit IIABC 4587599 13703686 O3K_22220 Escherichia coli O104:H4 str. 2011C-3493 PTS system glucose-specific transporter subunit IIABC YP_006781101.1 4586043 R 1133852 CDS YP_006781102.1 407483953 13703687 4587765..4588589 1 NC_018658.1 COG1737 Transcriptional regulators; transcriptional regulator 4588589 13703687 O3K_22225 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator YP_006781102.1 4587765 D 1133852 CDS YP_006781103.1 407483954 13703688 complement(4588761..4589264) 1 NC_018658.1 COG1662 Transposase and inactivated derivatives, IS1 family; IS1; transposase ORF B, IS1 4589264 13703688 O3K_22230 Escherichia coli O104:H4 str. 2011C-3493 transposase ORF B, IS1 YP_006781103.1 4588761 R 1133852 CDS YP_006781104.1 407483955 13703689 complement(4589183..4589458) 1 NC_018658.1 COG3677 Transposase and inactivated derivatives; IS1 repressor protein InsA, KpLE2 phage-like element 4589458 13703689 O3K_22235 Escherichia coli O104:H4 str. 2011C-3493 IS1 repressor protein InsA, KpLE2 phage-like element YP_006781104.1 4589183 R 1133852 CDS YP_006781105.1 407483956 13703690 4589500..4590129 1 NC_018658.1 hypothetical protein 4590129 13703690 O3K_22240 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781105.1 4589500 D 1133852 CDS YP_006781106.1 407483957 13703691 complement(4590180..4591256) 1 NC_018658.1 COG3177 Uncharacterized conserved protein; Filamentation induced by cAMP protein Fic 4591256 13703691 O3K_22245 Escherichia coli O104:H4 str. 2011C-3493 Filamentation induced by cAMP protein Fic YP_006781106.1 4590180 R 1133852 CDS YP_006781107.1 407483958 13703692 complement(4591746..4592042) 1 NC_018658.1 COG1396 Predicted transcriptional regulators; transcriptional regulator 4592042 13703692 O3K_22250 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator YP_006781107.1 4591746 R 1133852 CDS YP_006781108.1 407483959 13703693 4592962..4593237 1 NC_018658.1 COG3677 Transposase and inactivated derivatives; InsA 4593237 13703693 O3K_22255 Escherichia coli O104:H4 str. 2011C-3493 InsA YP_006781108.1 4592962 D 1133852 CDS YP_006781109.1 407483960 13703694 4593156..4593659 1 NC_018658.1 COG1662 Transposase and inactivated derivatives, IS1 family; IS1 transposase InsAB' 4593659 13703694 O3K_22260 Escherichia coli O104:H4 str. 2011C-3493 IS1 transposase InsAB' YP_006781109.1 4593156 D 1133852 CDS YP_006781110.1 407483961 13703695 4593713..4594093 1 NC_018658.1 COG0064 Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog); hypothetical protein 4594093 13703695 O3K_22265 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781110.1 4593713 D 1133852 CDS YP_006781111.1 407483962 13703696 4594338..4595210 1 NC_018658.1 COG3440 Predicted restriction endonuclease; hypothetical protein 4595210 13703696 O3K_22270 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781111.1 4594338 D 1133852 CDS YP_006781112.1 407483963 13703697 4595578..4595871 1 NC_018658.1 hypothetical protein 4595871 13703697 O3K_22275 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781112.1 4595578 D 1133852 CDS YP_006781113.1 407483964 13703698 4595957..4597162 1 NC_018658.1 COG4227 Antirestriction protein; hypothetical protein 4597162 13703698 O3K_22280 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781113.1 4595957 D 1133852 CDS YP_006781114.1 407483965 13703699 4597172..4598791 1 NC_018658.1 COG3481 Predicted HD-superfamily hydrolase; hypothetical protein 4598791 13703699 O3K_22285 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781114.1 4597172 D 1133852 CDS YP_006781115.1 407483966 13703700 4598781..4599707 1 NC_018658.1 COG0582 Integrase; hypothetical protein 4599707 13703700 O3K_22290 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781115.1 4598781 D 1133852 CDS YP_006781116.1 407483967 13703702 4600137..4601156 1 NC_018658.1 COG1064 Zn-dependent alcohol dehydrogenases; alcohol dehydrogenase, Zn-dependent and NAD(P)-binding protein 4601156 13703702 O3K_22295 Escherichia coli O104:H4 str. 2011C-3493 alcohol dehydrogenase, Zn-dependent and NAD(P)-binding protein YP_006781116.1 4600137 D 1133852 CDS YP_006781117.1 407483968 13703703 complement(4601160..4601723) 1 NC_018658.1 COG3265 Gluconate kinase; D-gluconate kinase 4601723 idnK 13703703 idnK Escherichia coli O104:H4 str. 2011C-3493 D-gluconate kinase YP_006781117.1 4601160 R 1133852 CDS YP_006781118.1 407483969 13703704 4601940..4602971 1 NC_018658.1 COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases; L-idonate 5-dehydrogenase 4602971 13703704 O3K_22305 Escherichia coli O104:H4 str. 2011C-3493 L-idonate 5-dehydrogenase YP_006781118.1 4601940 D 1133852 CDS YP_006781119.1 407483970 13703705 4602995..4603759 1 NC_018658.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); gluconate 5-dehydrogenase 4603759 13703705 O3K_22310 Escherichia coli O104:H4 str. 2011C-3493 gluconate 5-dehydrogenase YP_006781119.1 4602995 D 1133852 CDS YP_006781120.1 407483971 13703706 4603824..4605143 1 NC_018658.1 COG2610 H+/gluconate symporter and related permeases; Gnt-II system L-idonate transporter 4605143 13703706 O3K_22315 Escherichia coli O104:H4 str. 2011C-3493 Gnt-II system L-idonate transporter YP_006781120.1 4603824 D 1133852 CDS YP_006781121.1 407483972 13703707 4605210..4606208 1 NC_018658.1 COG1609 Transcriptional regulators; DNA-binding transcriptional repressor, 5-gluconate-binding protein 4606208 13703707 O3K_22320 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional repressor, 5-gluconate-binding protein YP_006781121.1 4605210 D 1133852 CDS YP_006781122.1 407483973 13703708 4606286..4607788 1 NC_018658.1 COG0433 Predicted ATPase; ATPase 4607788 13703708 O3K_22325 Escherichia coli O104:H4 str. 2011C-3493 ATPase YP_006781122.1 4606286 D 1133852 CDS YP_006781123.1 407483974 13703709 complement(4607907..4608989) 1 NC_018658.1 COG0795 Predicted permeases; lipopolysaccharide ABC transporter permease 4608989 13703709 O3K_22330 Escherichia coli O104:H4 str. 2011C-3493 lipopolysaccharide ABC transporter permease YP_006781123.1 4607907 R 1133852 CDS YP_006781124.1 407483975 13703710 complement(4608989..4610089) 1 NC_018658.1 COG0795 Predicted permeases; lipopolysaccharide ABC transporter permease LptF 4610089 13703710 O3K_22335 Escherichia coli O104:H4 str. 2011C-3493 lipopolysaccharide ABC transporter permease LptF YP_006781124.1 4608989 R 1133852 CDS YP_006781125.1 407483976 13703711 4610356..4611867 1 NC_018658.1 COG0260 Leucyl aminopeptidase; multifunctional aminopeptidase A 4611867 13703711 O3K_22340 Escherichia coli O104:H4 str. 2011C-3493 multifunctional aminopeptidase A YP_006781125.1 4610356 D 1133852 CDS YP_006781126.1 407483977 13703712 4612001..4612444 1 NC_018658.1 COG2927 DNA polymerase III, chi subunit; DNA polymerase III subunit chi 4612444 13703712 O3K_22345 Escherichia coli O104:H4 str. 2011C-3493 DNA polymerase III subunit chi YP_006781126.1 4612001 D 1133852 CDS YP_006781127.1 407483978 13703713 4612444..4615299 1 NC_018658.1 COG0525 Valyl-tRNA synthetase; valyl-tRNA synthetase 4615299 valS 13703713 valS Escherichia coli O104:H4 str. 2011C-3493 valyl-tRNA synthetase YP_006781127.1 4612444 D 1133852 CDS YP_006781128.1 407483979 13703714 complement(4615355..4616551) 1 NC_018658.1 COG4269 Predicted membrane protein; hypothetical protein 4616551 13703714 O3K_22355 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781128.1 4615355 R 1133852 CDS YP_006781129.1 407483980 13703715 4616744..4617247 1 NC_018658.1 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; acetyltransferase 4617247 13703715 O3K_22360 Escherichia coli O104:H4 str. 2011C-3493 acetyltransferase YP_006781129.1 4616744 D 1133852 CDS YP_006781130.1 407483981 13703716 complement(4617293..4617709) 1 NC_018658.1 COG3076 Uncharacterized protein conserved in bacteria; RNase E inhibitor protein 4617709 13703716 O3K_22365 Escherichia coli O104:H4 str. 2011C-3493 RNase E inhibitor protein YP_006781130.1 4617293 R 1133852 CDS YP_006781131.1 407483982 13703717 4617871..4618875 1 NC_018658.1 COG0078 Ornithine carbamoyltransferase; ornithine carbamoyltransferase subunit I 4618875 13703717 O3K_22370 Escherichia coli O104:H4 str. 2011C-3493 ornithine carbamoyltransferase subunit I YP_006781131.1 4617871 D 1133852 CDS YP_006781132.1 407484562 13703718 complement(4619218..4620537) 1 NC_018658.1 Protein YjgL, putative CCAAT-box DNA binding protein 4620537 13703718 O3K_26527 Escherichia coli O104:H4 str. 2011C-3493 Protein YjgL, putative CCAAT-box DNA binding protein YP_006781132.1 4619218 R 1133852 CDS YP_006781133.1 407483983 13700922 complement(4620660..4621112) 1 NC_018658.1 COG2731 Beta-galactosidase, beta subunit; hypothetical protein 4621112 13700922 O3K_22385 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781133.1 4620660 R 1133852 CDS YP_006781134.1 407483984 13703719 complement(4621257..4621850) 1 NC_018658.1 COG1309 Transcriptional regulator; transcriptional regulator 4621850 13703719 O3K_22390 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator YP_006781134.1 4621257 R 1133852 CDS YP_006781135.1 407483985 13703720 4621921..4622634 1 NC_018658.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); oxidoreductase 4622634 13703720 O3K_22395 Escherichia coli O104:H4 str. 2011C-3493 oxidoreductase YP_006781135.1 4621921 D 1133852 CDS YP_006781136.1 407483986 13703721 4622765..4623160 1 NC_018658.1 COG0251 Putative translation initiation inhibitor, yjgF family; putative mRNA endoribonuclease 4623160 13703721 O3K_22400 Escherichia coli O104:H4 str. 2011C-3493 putative mRNA endoribonuclease YP_006781136.1 4622765 D 1133852 CDS YP_006781137.1 407483987 13703722 4623384..4623575 1 NC_018658.1 pyrBI operon leader peptide 4623575 13703722 O3K_22405 Escherichia coli O104:H4 str. 2011C-3493 pyrBI operon leader peptide YP_006781137.1 4623384 D 1133852 CDS YP_006781138.1 407483988 13703723 4623579..4624514 1 NC_018658.1 COG0540 Aspartate carbamoyltransferase, catalytic chain; aspartate carbamoyltransferase catalytic subunit 4624514 pyrB 13703723 pyrB Escherichia coli O104:H4 str. 2011C-3493 aspartate carbamoyltransferase catalytic subunit YP_006781138.1 4623579 D 1133852 CDS YP_006781139.1 407483989 13703724 4624527..4624988 1 NC_018658.1 COG1781 Aspartate carbamoyltransferase, regulatory subunit; aspartate carbamoyltransferase regulatory subunit 4624988 13703724 O3K_22415 Escherichia coli O104:H4 str. 2011C-3493 aspartate carbamoyltransferase regulatory subunit YP_006781139.1 4624527 D 1133852 CDS YP_006781140.1 407483990 13703725 4625061..4625447 1 NC_018658.1 COG0251 Putative translation initiation inhibitor, yjgF family; hypothetical protein 4625447 13703725 O3K_22420 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781140.1 4625061 D 1133852 CDS YP_006781141.1 407483991 13703726 4625724..4626704 1 NC_018658.1 COG3547 Transposase and inactivated derivatives; IS621 transposase 4626704 13703726 O3K_22425 Escherichia coli O104:H4 str. 2011C-3493 IS621 transposase YP_006781141.1 4625724 D 1133852 CDS YP_006781142.1 407483992 13703727 complement(4626932..4629628) 1 NC_018658.1 COG0474 Cation transport ATPase; magnesium-transporting ATPase MgtA 4629628 13703727 O3K_22430 Escherichia coli O104:H4 str. 2011C-3493 magnesium-transporting ATPase MgtA YP_006781142.1 4626932 R 1133852 CDS YP_006781143.1 407483993 13703728 4630007..4630954 1 NC_018658.1 COG1609 Transcriptional regulators; trehalose repressor 4630954 treR 13703728 treR Escherichia coli O104:H4 str. 2011C-3493 trehalose repressor YP_006781143.1 4630007 D 1133852 CDS YP_006781144.1 407483994 13703729 4631076..4632494 1 NC_018658.1 COG1264 Phosphotransferase system IIB components; PTS system trehalose(maltose)-specific transporter subunit IIBC 4632494 13703729 O3K_22440 Escherichia coli O104:H4 str. 2011C-3493 PTS system trehalose(maltose)-specific transporter subunit IIBC YP_006781144.1 4631076 D 1133852 CDS YP_006781145.1 407483995 13703730 4632544..4634199 1 NC_018658.1 COG0366 Glycosidases; trehalose-6-phosphate hydrolase 4634199 13703730 O3K_22445 Escherichia coli O104:H4 str. 2011C-3493 trehalose-6-phosphate hydrolase YP_006781145.1 4632544 D 1133852 CDS YP_006781146.1 407483996 13703731 4634602..4636740 1 NC_018658.1 COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase; anaerobic ribonucleoside triphosphate reductase 4636740 13703731 O3K_22450 Escherichia coli O104:H4 str. 2011C-3493 anaerobic ribonucleoside triphosphate reductase YP_006781146.1 4634602 D 1133852 CDS YP_006781147.1 407483997 13703732 4636898..4637362 1 NC_018658.1 COG0602 Organic radical activating enzymes; anaerobic ribonucleotide reductase-activating protein 4637362 nrdG 13703732 nrdG Escherichia coli O104:H4 str. 2011C-3493 anaerobic ribonucleotide reductase-activating protein YP_006781147.1 4636898 D 1133852 CDS YP_006781148.1 407483998 13703733 complement(4637407..4637793) 1 NC_018658.1 COG3783 Soluble cytochrome b562; cytochrome b562 4637793 13703733 O3K_22460 Escherichia coli O104:H4 str. 2011C-3493 cytochrome b562 YP_006781148.1 4637407 R 1133852 CDS YP_006781149.1 407483999 13703734 complement(4637976..4639316) 1 NC_018658.1 COG0312 Predicted Zn-dependent proteases and their inactivated homologs; peptidase PmbA 4639316 13703734 O3K_22465 Escherichia coli O104:H4 str. 2011C-3493 peptidase PmbA YP_006781149.1 4637976 R 1133852 CDS YP_006781150.1 407484000 13703735 4639422..4639973 1 NC_018658.1 COG3028 Uncharacterized protein conserved in bacteria; hypothetical protein 4639973 13703735 O3K_22470 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781150.1 4639422 D 1133852 CDS YP_006781151.1 407484001 13703736 complement(4640124..4641497) 1 NC_018658.1 COG0773 UDP-N-acetylmuramate-alanine ligase; UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase 4641497 13703736 O3K_22475 Escherichia coli O104:H4 str. 2011C-3493 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase YP_006781151.1 4640124 R 1133852 CDS YP_006781152.1 407484002 13703737 4641673..4642671 1 NC_018658.1 COG0158 Fructose-1,6-bisphosphatase; fructose-1,6-bisphosphatase 4642671 13703737 O3K_22480 Escherichia coli O104:H4 str. 2011C-3493 fructose-1,6-bisphosphatase YP_006781152.1 4641673 D 1133852 CDS YP_006781153.1 407484003 13703738 complement(4642704..4643699) 1 NC_018658.1 COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components; inner membrane ABC transporter permease YjfF 4643699 13703738 O3K_22485 Escherichia coli O104:H4 str. 2011C-3493 inner membrane ABC transporter permease YjfF YP_006781153.1 4642704 R 1133852 CDS YP_006781154.1 407484004 13703739 complement(4643686..4644708) 1 NC_018658.1 COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components; sugar ABC transporter permease 4644708 13703739 O3K_22490 Escherichia coli O104:H4 str. 2011C-3493 sugar ABC transporter permease YP_006781154.1 4643686 R 1133852 CDS YP_006781155.1 407484005 13703740 complement(4644722..4646224) 1 NC_018658.1 COG1129 ABC-type sugar transport system, ATPase component; sugar ABC transporter ATP-binding protein 4646224 13703740 O3K_22495 Escherichia coli O104:H4 str. 2011C-3493 sugar ABC transporter ATP-binding protein YP_006781155.1 4644722 R 1133852 CDS YP_006781156.1 407484006 13703741 complement(4646534..4647490) 1 NC_018658.1 COG1879 ABC-type sugar transport system, periplasmic component; putative sugar transporter subunit 4647490 13703741 O3K_22500 Escherichia coli O104:H4 str. 2011C-3493 putative sugar transporter subunit YP_006781156.1 4646534 R 1133852 CDS YP_006781157.1 407484007 13703742 4647800..4648330 1 NC_018658.1 COG0221 Inorganic pyrophosphatase; inorganic pyrophosphatase 4648330 13703742 O3K_22505 Escherichia coli O104:H4 str. 2011C-3493 inorganic pyrophosphatase YP_006781157.1 4647800 D 1133852 CDS YP_006781158.1 407484008 13703743 complement(4648410..4648760) 1 NC_018658.1 COG2337 Growth inhibitor; toxin ChpB 4648760 13703743 O3K_22510 Escherichia coli O104:H4 str. 2011C-3493 toxin ChpB YP_006781158.1 4648410 R 1133852 CDS YP_006781159.1 407484009 13703744 complement(4648754..4649005) 1 NC_018658.1 COG2336 Growth regulator; antitoxin ChpS 4649005 13703744 O3K_22515 Escherichia coli O104:H4 str. 2011C-3493 antitoxin ChpS YP_006781159.1 4648754 R 1133852 CDS YP_006781160.1 407484010 13703745 complement(4649217..4649558) 1 NC_018658.1 COG2105 Uncharacterized conserved protein; hypothetical protein 4649558 13703745 O3K_22520 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781160.1 4649217 R 1133852 CDS YP_006781161.1 407484011 13703746 complement(4649561..4653340) 1 NC_018658.1 COG2911 Uncharacterized protein conserved in bacteria; hypothetical protein 4653340 13703746 O3K_22525 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781161.1 4649561 R 1133852 CDS YP_006781162.1 407484012 13703747 complement(4653337..4655070) 1 NC_018658.1 COG0729 Outer membrane protein; surface antigen 4655070 13703747 O3K_22530 Escherichia coli O104:H4 str. 2011C-3493 surface antigen YP_006781162.1 4653337 R 1133852 CDS YP_006781163.1 407484013 13703748 complement(4655040..4655168) 1 NC_018658.1 COG1131 ABC-type multidrug transport system, ATPase component; hypothetical protein 4655168 13703748 O3K_22535 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781163.1 4655040 R 1133852 CDS YP_006781164.1 407484014 13703749 4655276..4655914 1 NC_018658.1 COG0225 Peptide methionine sulfoxide reductase; methionine sulfoxide reductase A 4655914 13703749 O3K_22540 Escherichia coli O104:H4 str. 2011C-3493 methionine sulfoxide reductase A YP_006781164.1 4655276 D 1133852 CDS YP_006781165.1 407484015 13703750 4656237..4657580 1 NC_018658.1 COG1253 Hemolysins and related proteins containing CBS domains; inner membrane protein 4657580 13703750 O3K_22545 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006781165.1 4656237 D 1133852 CDS YP_006781166.1 407484016 13703751 complement(4657642..4657848) 1 NC_018658.1 COG1117 ABC-type phosphate transport system, ATPase component; hypothetical protein 4657848 13703751 O3K_22550 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781166.1 4657642 R 1133852 CDS YP_006781167.1 407484017 13703752 4658173..4658730 1 NC_018658.1 COG3054 Predicted transcriptional regulator; transcriptional regulator 4658730 13703752 O3K_22555 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator YP_006781167.1 4658173 D 1133852 CDS YP_006781168.1 407484018 13703753 complement(4658720..4659460) 1 NC_018658.1 COG1218 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase; adenosine-3'(2'),5'-bisphosphate nucleotidase 4659460 13703753 O3K_22560 Escherichia coli O104:H4 str. 2011C-3493 adenosine-3'(2'),5'-bisphosphate nucleotidase YP_006781168.1 4658720 R 1133852 CDS YP_006781169.1 407484019 13703754 4659650..4661593 1 NC_018658.1 COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein 4661593 cpdB 13703754 cpdB Escherichia coli O104:H4 str. 2011C-3493 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein YP_006781169.1 4659650 D 1133852 CDS YP_006781170.1 407484020 13703755 complement(4661722..4662102) 1 NC_018658.1 COG1733 Predicted transcriptional regulators; hypothetical protein 4662102 13703755 O3K_22570 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781170.1 4661722 R 1133852 CDS YP_006781171.1 407484021 13703756 4662191..4663051 1 NC_018658.1 COG0702 Predicted nucleoside-diphosphate-sugar epimerases; NAD(P)H:quinone oxidoreductase 4663051 13703756 O3K_22575 Escherichia coli O104:H4 str. 2011C-3493 NAD(P)H:quinone oxidoreductase YP_006781171.1 4662191 D 1133852 CDS YP_006781172.1 407484022 13703757 4663159..4664124 1 NC_018658.1 COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; inner membrane protein 4664124 13703757 O3K_22580 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006781172.1 4663159 D 1133852 CDS YP_006781173.1 407484023 13703758 4664232..4664894 1 NC_018658.1 COG2846 Regulator of cell morphogenesis and NO signaling; iron-sulfur cluster repair di-iron protein 4664894 13703758 O3K_22585 Escherichia coli O104:H4 str. 2011C-3493 iron-sulfur cluster repair di-iron protein YP_006781173.1 4664232 D 1133852 CDS YP_006781174.1 407484024 13703759 complement(4664939..4666351) 1 NC_018658.1 COG1113 Gamma-aminobutyrate permease and related permeases; D-alanine/D-serine/glycine permease 4666351 13703759 O3K_22590 Escherichia coli O104:H4 str. 2011C-3493 D-alanine/D-serine/glycine permease YP_006781174.1 4664939 R 1133852 CDS YP_006781175.1 407484025 13703760 complement(4666660..4667280) 1 NC_018658.1 COG0545 FKBP-type peptidyl-prolyl cis-trans isomerases 1; peptidyl-prolyl cis-trans isomerase 4667280 13703760 O3K_22595 Escherichia coli O104:H4 str. 2011C-3493 peptidyl-prolyl cis-trans isomerase YP_006781175.1 4666660 R 1133852 CDS YP_006781176.1 407484026 13703761 4667499..4668137 1 NC_018658.1 COG3061 Cell envelope opacity-associated protein A; putative cell envelope opacity-associated protein 4668137 13703761 O3K_22600 Escherichia coli O104:H4 str. 2011C-3493 putative cell envelope opacity-associated protein YP_006781176.1 4667499 D 1133852 CDS YP_006781177.1 407484027 13703762 complement(4668272..4669480) 1 NC_018658.1 COG0675 Transposase and inactivated derivatives; transposase 4669480 13703762 O3K_22605 Escherichia coli O104:H4 str. 2011C-3493 transposase YP_006781177.1 4668272 R 1133852 CDS YP_006781178.1 407484028 13699784 4669488..4669919 1 NC_018658.1 COG1943 Transposase and inactivated derivatives; transposase 4669919 13699784 O3K_22610 Escherichia coli O104:H4 str. 2011C-3493 transposase YP_006781178.1 4669488 D 1133852 CDS YP_006781179.1 407484029 13699785 4670542..4671336 1 NC_018658.1 hypothetical protein 4671336 13699785 O3K_22615 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781179.1 4670542 D 1133852 CDS YP_006781180.1 407484030 13699786 complement(4671407..4671856) 1 NC_018658.1 COG0359 Ribosomal protein L9; 50S ribosomal protein L9 4671856 rplI 13699786 rplI Escherichia coli O104:H4 str. 2011C-3493 50S ribosomal protein L9 YP_006781180.1 4671407 R 1133852 CDS YP_006781181.1 407484031 13699787 complement(4671898..4672125) 1 NC_018658.1 COG0238 Ribosomal protein S18; 30S ribosomal protein S18 4672125 rpsR 13699787 rpsR Escherichia coli O104:H4 str. 2011C-3493 30S ribosomal protein S18 YP_006781181.1 4671898 R 1133852 CDS YP_006781182.1 407484032 13699788 complement(4672130..4672444) 1 NC_018658.1 COG2965 Primosomal replication protein N; primosomal replication protein N 4672444 13699788 O3K_22630 Escherichia coli O104:H4 str. 2011C-3493 primosomal replication protein N YP_006781182.1 4672130 R 1133852 CDS YP_006781183.1 407484033 13699789 complement(4672451..4672846) 1 NC_018658.1 COG0360 Ribosomal protein S6; 30S ribosomal protein S6 4672846 rpsF 13699789 rpsF Escherichia coli O104:H4 str. 2011C-3493 30S ribosomal protein S6 YP_006781183.1 4672451 R 1133852 CDS YP_006781184.1 407484034 13699790 4673173..4673448 1 NC_018658.1 hypothetical protein 4673448 13699790 O3K_22640 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781184.1 4673173 D 1133852 CDS YP_006781185.1 407484035 13699791 complement(4673523..4674074) 1 NC_018658.1 COG3477 Predicted periplasmic/secreted protein; Inner membrane protein yagU 4674074 13699791 O3K_22645 Escherichia coli O104:H4 str. 2011C-3493 Inner membrane protein yagU YP_006781185.1 4673523 R 1133852 CDS YP_006781186.1 407484036 13699792 complement(4674171..4674857) 1 NC_018658.1 COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases; L-ribulose-5-phosphate 4-epimerase 4674857 sgaE 13699792 sgaE Escherichia coli O104:H4 str. 2011C-3493 L-ribulose-5-phosphate 4-epimerase YP_006781186.1 4674171 R 1133852 CDS YP_006781187.1 407484037 13699793 complement(4674857..4675711) 1 NC_018658.1 COG3623 Putative L-xylulose-5-phosphate 3-epimerase; L-xylulose 5-phosphate 3-epimerase 4675711 13699793 O3K_22655 Escherichia coli O104:H4 str. 2011C-3493 L-xylulose 5-phosphate 3-epimerase YP_006781187.1 4674857 R 1133852 CDS YP_006781188.1 407484038 13699794 complement(4675721..4676371) 1 NC_018658.1 COG0269 3-hexulose-6-phosphate synthase and related proteins; 3-keto-L-gulonate-6-phosphate decarboxylase 4676371 ulaD 13699794 ulaD Escherichia coli O104:H4 str. 2011C-3493 3-keto-L-gulonate-6-phosphate decarboxylase YP_006781188.1 4675721 R 1133852 CDS YP_006781189.1 407484039 13699795 complement(4676385..4676849) 1 NC_018658.1 COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type); PTS system L-ascorbate-specific transporter subunit IIA 4676849 13699795 O3K_22665 Escherichia coli O104:H4 str. 2011C-3493 PTS system L-ascorbate-specific transporter subunit IIA YP_006781189.1 4676385 R 1133852 CDS YP_006781190.1 407484040 13699796 complement(4676859..4677164) 1 NC_018658.1 COG3414 Phosphotransferase system, galactitol-specific IIB component; PTS system L-ascorbate-specific transporter subunit IIB 4677164 13699796 O3K_22670 Escherichia coli O104:H4 str. 2011C-3493 PTS system L-ascorbate-specific transporter subunit IIB YP_006781190.1 4676859 R 1133852 CDS YP_006781191.1 407484041 13699797 complement(4677180..4678577) 1 NC_018658.1 COG3037 Uncharacterized protein conserved in bacteria; PTS system ascorbate-specific transporter subunit IIC 4678577 ulaA 13699797 ulaA Escherichia coli O104:H4 str. 2011C-3493 PTS system ascorbate-specific transporter subunit IIC YP_006781191.1 4677180 R 1133852 CDS YP_006781192.1 407484042 13699798 4678932..4679996 1 NC_018658.1 COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold; L-ascorbate 6-phosphate lactonase 4679996 13699798 O3K_22680 Escherichia coli O104:H4 str. 2011C-3493 L-ascorbate 6-phosphate lactonase YP_006781192.1 4678932 D 1133852 CDS YP_006781193.1 407484043 13699799 4680104..4680859 1 NC_018658.1 COG1349 Transcriptional regulators of sugar metabolism; transcriptional repressor UlaR 4680859 13699799 O3K_22685 Escherichia coli O104:H4 str. 2011C-3493 transcriptional repressor UlaR YP_006781193.1 4680104 D 1133852 CDS YP_006781194.1 407484044 13699800 complement(4680856..4681605) 1 NC_018658.1 COG1073 Hydrolases of the alpha/beta superfamily; esterase 4681605 13699800 O3K_22690 Escherichia coli O104:H4 str. 2011C-3493 esterase YP_006781194.1 4680856 R 1133852 CDS YP_006781195.1 407484045 13699801 4681787..4682116 1 NC_018658.1 putative biofilm stress and motility protein A 4682116 13699801 O3K_22695 Escherichia coli O104:H4 str. 2011C-3493 putative biofilm stress and motility protein A YP_006781195.1 4681787 D 1133852 CDS YP_006781196.1 407484046 13699802 4682265..4682540 1 NC_018658.1 hypothetical protein 4682540 13699802 O3K_22700 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781196.1 4682265 D 1133852 CDS YP_006781197.1 407484047 13699803 complement(4682657..4684282) 1 NC_018658.1 COG1960 Acyl-CoA dehydrogenases; isovaleryl CoA dehydrogenase 4684282 13699803 O3K_22705 Escherichia coli O104:H4 str. 2011C-3493 isovaleryl CoA dehydrogenase YP_006781197.1 4682657 R 1133852 CDS YP_006781198.1 407484048 13699804 complement(4684366..4685529) 1 NC_018658.1 COG0754 Glutathionylspermidine synthase; synthetase/amidase 4685529 13699804 O3K_22710 Escherichia coli O104:H4 str. 2011C-3493 synthetase/amidase YP_006781198.1 4684366 R 1133852 CDS YP_006781199.1 407484049 13699805 complement(4685532..4686170) 1 NC_018658.1 hypothetical protein 4686170 13699805 O3K_22715 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781199.1 4685532 R 1133852 CDS YP_006781200.1 407484050 13699806 complement(4686180..4686413) 1 NC_018658.1 COG3766 Predicted membrane protein; inner membrane protein 4686413 13699806 O3K_22720 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006781200.1 4686180 R 1133852 CDS YP_006781201.1 407484051 13699807 complement(4686468..4686578) 1 NC_018658.1 COG3766 Predicted membrane protein; inner membrane protein 4686578 13699807 O3K_22725 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006781201.1 4686468 R 1133852 CDS YP_006781202.1 407484052 13699808 complement(4686596..4687255) 1 NC_018658.1 hypothetical protein 4687255 13699808 O3K_22730 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781202.1 4686596 R 1133852 CDS YP_006781203.1 407484053 13699809 complement(4687306..4688004) 1 NC_018658.1 COG1842 Phage shock protein A (IM30), suppresses sigma54-dependent transcription; putative transcriptional regulator effector protein 4688004 13699809 O3K_22735 Escherichia coli O104:H4 str. 2011C-3493 putative transcriptional regulator effector protein YP_006781203.1 4687306 R 1133852 CDS YP_006781204.1 407484054 13699810 complement(4688023..4688424) 1 NC_018658.1 COG3789 Uncharacterized protein conserved in bacteria; putative cytoplasmic protein 4688424 13699810 O3K_22740 Escherichia coli O104:H4 str. 2011C-3493 putative cytoplasmic protein YP_006781204.1 4688023 R 1133852 CDS YP_006781205.1 407484055 13699811 complement(4688551..4689282) 1 NC_018658.1 COG0566 rRNA methylases; 23S rRNA (guanosine-2'-O-)-methyltransferase 4689282 13699811 O3K_22745 Escherichia coli O104:H4 str. 2011C-3493 23S rRNA (guanosine-2'-O-)-methyltransferase YP_006781205.1 4688551 R 1133852 CDS YP_006781206.1 407484056 13699812 complement(4689462..4691903) 1 NC_018658.1 COG0557 Exoribonuclease R; exoribonuclease R 4691903 13699812 O3K_22750 Escherichia coli O104:H4 str. 2011C-3493 exoribonuclease R YP_006781206.1 4689462 R 1133852 CDS YP_006781207.1 407484057 13699813 complement(4691942..4692367) 1 NC_018658.1 COG1959 Predicted transcriptional regulator; transcriptional repressor NsrR 4692367 13699813 O3K_22755 Escherichia coli O104:H4 str. 2011C-3493 transcriptional repressor NsrR YP_006781207.1 4691942 R 1133852 CDS YP_006781208.1 407484058 13699814 complement(4692572..4693870) 1 NC_018658.1 COG0104 Adenylosuccinate synthase; adenylosuccinate synthetase 4693870 13699814 O3K_22760 Escherichia coli O104:H4 str. 2011C-3493 adenylosuccinate synthetase YP_006781208.1 4692572 R 1133852 CDS YP_006781209.1 407484059 13699815 complement(4693974..4694171) 1 NC_018658.1 COG3242 Uncharacterized protein conserved in bacteria; hypothetical protein 4694171 13699815 O3K_22765 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781209.1 4693974 R 1133852 CDS YP_006781210.1 407484060 13699816 complement(4694253..4695257) 1 NC_018658.1 COG0330 Membrane protease subunits, stomatin/prohibitin homologs; FtsH protease regulator HflC 4695257 13699816 O3K_22770 Escherichia coli O104:H4 str. 2011C-3493 FtsH protease regulator HflC YP_006781210.1 4694253 R 1133852 CDS YP_006781211.1 407484061 13699817 complement(4695260..4696519) 1 NC_018658.1 COG0330 Membrane protease subunits, stomatin/prohibitin homologs; FtsH protease regulator HflK 4696519 13699817 O3K_22775 Escherichia coli O104:H4 str. 2011C-3493 FtsH protease regulator HflK YP_006781211.1 4695260 R 1133852 CDS YP_006781212.1 407484062 13699818 complement(4696605..4697885) 1 NC_018658.1 COG2262 GTPases; GTPase HflX 4697885 13699818 O3K_22780 Escherichia coli O104:H4 str. 2011C-3493 GTPase HflX YP_006781212.1 4696605 R 1133852 CDS YP_006781213.1 407484063 13699819 complement(4697962..4698270) 1 NC_018658.1 COG1923 Uncharacterized host factor I protein; RNA-binding protein Hfq 4698270 hfq 13699819 hfq Escherichia coli O104:H4 str. 2011C-3493 RNA-binding protein Hfq YP_006781213.1 4697962 R 1133852 CDS YP_006781214.1 407484064 13699820 complement(4698356..4699306) 1 NC_018658.1 COG0324 tRNA delta(2)-isopentenylpyrophosphate transferase; tRNA delta(2)-isopentenylpyrophosphate transferase 4699306 miaA 13699820 miaA Escherichia coli O104:H4 str. 2011C-3493 tRNA delta(2)-isopentenylpyrophosphate transferase YP_006781214.1 4698356 R 1133852 CDS YP_006781215.1 407484065 13699821 complement(4699299..4701146) 1 NC_018658.1 COG0323 DNA mismatch repair enzyme (predicted ATPase); DNA mismatch repair protein 4701146 mutL 13699821 mutL Escherichia coli O104:H4 str. 2011C-3493 DNA mismatch repair protein YP_006781215.1 4699299 R 1133852 CDS YP_006781216.1 407484066 13699822 complement(4701156..4702493) 1 NC_018658.1 COG0860 N-acetylmuramoyl-L-alanine amidase; N-acetylmuramoyl-l-alanine amidase II 4702493 13699822 O3K_22800 Escherichia coli O104:H4 str. 2011C-3493 N-acetylmuramoyl-l-alanine amidase II YP_006781216.1 4701156 R 1133852 CDS YP_006781217.1 407484067 13699823 complement(4702512..4702973) 1 NC_018658.1 COG0802 Predicted ATPase or kinase; ADP-binding protein 4702973 13699823 O3K_22805 Escherichia coli O104:H4 str. 2011C-3493 ADP-binding protein YP_006781217.1 4702512 R 1133852 CDS YP_006781218.1 407484068 13699824 complement(4702945..4704492) 1 NC_018658.1 COG0062 Uncharacterized conserved protein; putative carbohydrate kinase 4704492 13699824 O3K_22810 Escherichia coli O104:H4 str. 2011C-3493 putative carbohydrate kinase YP_006781218.1 4702945 R 1133852 CDS YP_006781219.1 407484069 13699825 4704491..4705630 1 NC_018658.1 COG1600 Uncharacterized Fe-S protein; Fe-S electron transport protein 4705630 13699825 O3K_22815 Escherichia coli O104:H4 str. 2011C-3493 Fe-S electron transport protein YP_006781219.1 4704491 D 1133852 CDS YP_006781220.1 407484070 13699827 complement(4706186..4706731) 1 NC_018658.1 COG1949 Oligoribonuclease (3'->5' exoribonuclease); oligoribonuclease 4706731 13699827 O3K_22820 Escherichia coli O104:H4 str. 2011C-3493 oligoribonuclease YP_006781220.1 4706186 R 1133852 CDS YP_006781221.1 407484071 13699828 4706826..4707878 1 NC_018658.1 COG1162 Predicted GTPases; GTPase RsgA 4707878 13699828 O3K_22825 Escherichia coli O104:H4 str. 2011C-3493 GTPase RsgA YP_006781221.1 4706826 D 1133852 CDS YP_006781222.1 407484072 13699829 4707975..4708943 1 NC_018658.1 COG0688 Phosphatidylserine decarboxylase; phosphatidylserine decarboxylase 4708943 psd 13699829 psd Escherichia coli O104:H4 str. 2011C-3493 phosphatidylserine decarboxylase YP_006781222.1 4707975 D 1133852 CDS YP_006781223.1 407484073 13699830 4708965..4712288 1 NC_018658.1 COG3264 Small-conductance mechanosensitive channel; putative mechanosensitive channel protein 4712288 13699830 O3K_22835 Escherichia coli O104:H4 str. 2011C-3493 putative mechanosensitive channel protein YP_006781223.1 4708965 D 1133852 CDS YP_006781224.1 407484074 13699831 complement(4712317..4712631) 1 NC_018658.1 hypothetical protein 4712631 13699831 O3K_22840 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781224.1 4712317 R 1133852 CDS YP_006781225.1 407484075 13699832 complement(4712628..4712942) 1 NC_018658.1 hypothetical protein 4712942 13699832 O3K_22845 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781225.1 4712628 R 1133852 CDS YP_006781226.1 407484076 13699833 complement(4712994..4714496) 1 NC_018658.1 COG0531 Amino acid transporters; inner membrane transporter YjeM 4714496 13699833 O3K_22850 Escherichia coli O104:H4 str. 2011C-3493 inner membrane transporter YjeM YP_006781226.1 4712994 R 1133852 CDS YP_006781227.1 407484077 13699834 complement(4714715..4715692) 1 NC_018658.1 COG2269 Truncated, possibly inactive, lysyl-tRNA synthetase (class II); poxB regulator PoxA 4715692 13699834 O3K_22855 Escherichia coli O104:H4 str. 2011C-3493 poxB regulator PoxA YP_006781227.1 4714715 R 1133852 CDS YP_006781228.1 407484078 13699835 4716017..4717825 1 NC_018658.1 COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; fumarate reductase flavoprotein subunit 4717825 13699835 O3K_22860 Escherichia coli O104:H4 str. 2011C-3493 fumarate reductase flavoprotein subunit YP_006781228.1 4716017 D 1133852 CDS YP_006781229.1 407484079 13699836 4717818..4718552 1 NC_018658.1 COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit; fumarate reductase iron-sulfur subunit 4718552 13699836 O3K_22865 Escherichia coli O104:H4 str. 2011C-3493 fumarate reductase iron-sulfur subunit YP_006781229.1 4717818 D 1133852 CDS YP_006781230.1 407484080 13699837 4718563..4718958 1 NC_018658.1 COG3029 Fumarate reductase subunit C; fumarate reductase subunit C 4718958 13699837 O3K_22870 Escherichia coli O104:H4 str. 2011C-3493 fumarate reductase subunit C YP_006781230.1 4718563 D 1133852 CDS YP_006781231.1 407484081 13699838 4718969..4719328 1 NC_018658.1 COG3080 Fumarate reductase subunit D; fumarate reductase subunit D 4719328 13699838 O3K_22875 Escherichia coli O104:H4 str. 2011C-3493 fumarate reductase subunit D YP_006781231.1 4718969 D 1133852 CDS YP_006781232.1 407484082 13699839 4719391..4720524 1 NC_018658.1 COG1680 Beta-lactamase class C and other penicillin binding proteins; beta-lactamase/D-alanine carboxypeptidase 4720524 ampC 13699839 ampC Escherichia coli O104:H4 str. 2011C-3493 beta-lactamase/D-alanine carboxypeptidase YP_006781232.1 4719391 D 1133852 CDS YP_006781233.1 407484083 13699840 4720613..4721146 1 NC_018658.1 COG3040 Bacterial lipocalin; outer membrane lipoprotein Blc 4721146 13699840 O3K_22885 Escherichia coli O104:H4 str. 2011C-3493 outer membrane lipoprotein Blc YP_006781233.1 4720613 D 1133852 CDS YP_006781234.1 407484084 13699841 complement(4721143..4721460) 1 NC_018658.1 COG2076 Membrane transporters of cations and cationic drugs; suppresser of groEL 4721460 13699841 O3K_22890 Escherichia coli O104:H4 str. 2011C-3493 suppresser of groEL YP_006781234.1 4721143 R 1133852 CDS YP_006781235.1 407484085 13699842 complement(4721635..4721781) 1 NC_018658.1 COG5510 Predicted small secreted protein; entericidin B membrane lipoprotein 4721781 13699842 O3K_22895 Escherichia coli O104:H4 str. 2011C-3493 entericidin B membrane lipoprotein YP_006781235.1 4721635 R 1133852 CDS YP_006781236.1 407484086 13699843 complement(4721892..4722017) 1 NC_018658.1 entericidin A 4722017 13699843 O3K_22900 Escherichia coli O104:H4 str. 2011C-3493 entericidin A YP_006781236.1 4721892 R 1133852 CDS YP_006781237.1 407484087 13699844 complement(4722069..4722635) 1 NC_018658.1 COG0231 Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A); elongation factor P 4722635 13699844 O3K_22905 Escherichia coli O104:H4 str. 2011C-3493 elongation factor P YP_006781237.1 4722069 R 1133852 CDS YP_006781238.1 407484088 13699845 4722677..4723705 1 NC_018658.1 COG1509 Lysine 2,3-aminomutase; putative lysine aminomutase 4723705 13699845 O3K_22910 Escherichia coli O104:H4 str. 2011C-3493 putative lysine aminomutase YP_006781238.1 4722677 D 1133852 CDS YP_006781239.1 407484089 13699846 4724095..4724964 1 NC_018658.1 COG5257 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase); hypothetical protein 4724964 13699846 O3K_22915 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781239.1 4724095 D 1133852 CDS YP_006781240.1 407484090 13699847 complement(4725167..4725520) 1 NC_018658.1 hypothetical protein 4725520 13699847 O3K_22920 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781240.1 4725167 R 1133852 CDS YP_006781241.1 407484091 13699848 complement(4725658..4727304) 1 NC_018658.1 COG0459 Chaperonin GroEL (HSP60 family); chaperonin GroEL 4727304 groEL 13699848 groEL Escherichia coli O104:H4 str. 2011C-3493 chaperonin GroEL YP_006781241.1 4725658 R 1133852 CDS YP_006781242.1 407484092 13699849 complement(4727348..4727641) 1 NC_018658.1 COG0234 Co-chaperonin GroES (HSP10); co-chaperonin GroES 4727641 groES 13699849 groES Escherichia coli O104:H4 str. 2011C-3493 co-chaperonin GroES YP_006781242.1 4727348 R 1133852 CDS YP_006781243.1 407484093 13699850 4727917..4729173 1 NC_018658.1 COG0531 Amino acid transporters; transporter 4729173 13699850 O3K_22935 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006781243.1 4727917 D 1133852 CDS YP_006781244.1 407484094 13699851 complement(4729189..4729665) 1 NC_018658.1 COG3030 Protein affecting phage T7 exclusion by the F plasmid; phage T7 F exclusion suppressor FxsA 4729665 fxsA 13699851 fxsA Escherichia coli O104:H4 str. 2011C-3493 phage T7 F exclusion suppressor FxsA YP_006781244.1 4729189 R 1133852 CDS YP_006781245.1 407484095 13699852 4730002..4731438 1 NC_018658.1 COG1027 Aspartate ammonia-lyase; aspartate ammonia-lyase 4731438 aspA 13699852 aspA Escherichia coli O104:H4 str. 2011C-3493 aspartate ammonia-lyase YP_006781245.1 4730002 D 1133852 CDS YP_006781246.1 407484096 13699853 4731556..4732857 1 NC_018658.1 COG2704 Anaerobic C4-dicarboxylate transporter; anaerobic C4-dicarboxylate transporter 4732857 13699853 O3K_22950 Escherichia coli O104:H4 str. 2011C-3493 anaerobic C4-dicarboxylate transporter YP_006781246.1 4731556 D 1133852 CDS YP_006781247.1 407484097 13699854 4732973..4733311 1 NC_018658.1 COG1324 Uncharacterized protein involved in tolerance to divalent cations; divalent-cation tolerance protein CutA 4733311 13699854 O3K_22955 Escherichia coli O104:H4 str. 2011C-3493 divalent-cation tolerance protein CutA YP_006781247.1 4732973 D 1133852 CDS YP_006781248.1 407484098 13699855 4733287..4734984 1 NC_018658.1 COG4232 Thiol:disulfide interchange protein; thiol:disulfide interchange protein 4734984 dipZ 13699855 dipZ Escherichia coli O104:H4 str. 2011C-3493 thiol:disulfide interchange protein YP_006781248.1 4733287 D 1133852 CDS YP_006781249.1 407484099 13699856 4735021..4735596 1 NC_018658.1 COG1309 Transcriptional regulator; transcriptional regulator 4735596 13699856 O3K_22965 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator YP_006781249.1 4735021 D 1133852 CDS YP_006781250.1 407484100 13699858 4735976..4737238 1 NC_018658.1 COG0582 Integrase; Prophage integrase 4737238 13699858 O3K_22970 Escherichia coli O104:H4 str. 2011C-3493 Prophage integrase YP_006781250.1 4735976 D 1133852 CDS YP_006781251.1 407484101 13699859 4741547..4741912 1 NC_018658.1 COG3547 Transposase and inactivated derivatives; hypothetical protein 4741912 13699859 O3K_22985 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781251.1 4741547 D 1133852 CDS YP_006781252.1 407484102 13699860 complement(4741909..4742163) 1 NC_018658.1 COG3436 Transposase and inactivated derivatives; truncated transposase 4742163 13699860 O3K_22990 Escherichia coli O104:H4 str. 2011C-3493 truncated transposase YP_006781252.1 4741909 R 1133852 CDS YP_006781253.1 407484103 13699861 complement(4742241..4742489) 1 NC_018658.1 hypothetical protein 4742489 13699861 O3K_22995 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781253.1 4742241 R 1133852 CDS YP_006781254.1 407484104 13699862 4742556..4743317 1 NC_018658.1 hypothetical protein 4743317 13699862 O3K_23000 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781254.1 4742556 D 1133852 CDS YP_006781255.1 407484105 13699863 4743678..4747535 1 NC_018658.1 COG3468 Type V secretory pathway, adhesin AidA; Serine protease pet precursor (Plasmid-encoded toxin pet) 4747535 13699863 O3K_23005 Escherichia coli O104:H4 str. 2011C-3493 Serine protease pet precursor (Plasmid-encoded toxin pet) YP_006781255.1 4743678 D 1133852 CDS YP_006781256.1 407484106 13699864 4747582..4748163 1 NC_018658.1 hypothetical protein 4748163 13699864 O3K_23010 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781256.1 4747582 D 1133852 CDS YP_006781257.1 407484107 13699865 complement(4748355..4749758) 1 NC_018658.1 COG3436 Transposase and inactivated derivatives; transposase 4749758 13699865 O3K_23015 Escherichia coli O104:H4 str. 2011C-3493 transposase YP_006781257.1 4748355 R 1133852 CDS YP_006781258.1 407484108 13699866 complement(4749857..4750264) 1 NC_018658.1 COG3436 Transposase and inactivated derivatives; protein encoded within IS 4750264 13699866 O3K_23020 Escherichia coli O104:H4 str. 2011C-3493 protein encoded within IS YP_006781258.1 4749857 R 1133852 CDS YP_006781259.1 407484109 13699867 4750330..4750833 1 NC_018658.1 COG3464 Transposase and inactivated derivatives; transposase 4750833 13699867 O3K_23025 Escherichia coli O104:H4 str. 2011C-3493 transposase YP_006781259.1 4750330 D 1133852 CDS YP_006781260.1 407484110 13699868 4752062..4752487 1 NC_018658.1 COG2963 Transposase and inactivated derivatives; transposase OrfA from plasmid origin 4752487 13699868 O3K_23035 Escherichia coli O104:H4 str. 2011C-3493 transposase OrfA from plasmid origin YP_006781260.1 4752062 D 1133852 CDS YP_006781261.1 407484111 13699869 4752484..4752735 1 NC_018658.1 COG3436 Transposase and inactivated derivatives; IS66 transposase 4752735 13699869 O3K_23040 Escherichia coli O104:H4 str. 2011C-3493 IS66 transposase YP_006781261.1 4752484 D 1133852 CDS YP_006781262.1 407484112 13699870 4752761..4753087 1 NC_018658.1 COG2963 Transposase and inactivated derivatives; IS629 orfA 4753087 13699870 O3K_23045 Escherichia coli O104:H4 str. 2011C-3493 IS629 orfA YP_006781262.1 4752761 D 1133852 CDS YP_006781263.1 407484113 13699871 4754157..4755680 1 NC_018658.1 COG3344 Retron-type reverse transcriptase; reverse transcriptase-like protein from prophage or plasmid 4755680 13699871 O3K_23055 Escherichia coli O104:H4 str. 2011C-3493 reverse transcriptase-like protein from prophage or plasmid YP_006781263.1 4754157 D 1133852 CDS YP_006781264.1 407484114 13699872 complement(4756645..4758840) 1 NC_018658.1 COG1629 Outer membrane receptor proteins, mostly Fe transport; Ferric aerobactin receptor 4758840 13699872 O3K_23065 Escherichia coli O104:H4 str. 2011C-3493 Ferric aerobactin receptor YP_006781264.1 4756645 R 1133852 CDS YP_006781265.1 407484115 13699873 complement(4758846..4760183) 1 NC_018658.1 COG3486 Lysine/ornithine N-monooxygenase; L-lysine 6-monooxygenase (Lysine N(6)-hydroxylase) 4760183 13699873 O3K_23070 Escherichia coli O104:H4 str. 2011C-3493 L-lysine 6-monooxygenase (Lysine N(6)-hydroxylase) YP_006781265.1 4758846 R 1133852 CDS YP_006781266.1 407484116 13699874 complement(4760180..4761922) 1 NC_018658.1 COG4264 Siderophore synthetase component; Aerobactin siderophore biosynthesis protein 4761922 13699874 O3K_23075 Escherichia coli O104:H4 str. 2011C-3493 Aerobactin siderophore biosynthesis protein YP_006781266.1 4760180 R 1133852 CDS YP_006781267.1 407484117 13699875 complement(4761922..4762869) 1 NC_018658.1 COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins; siderophore biosynthesis protein 4762869 13699875 O3K_23080 Escherichia coli O104:H4 str. 2011C-3493 siderophore biosynthesis protein YP_006781267.1 4761922 R 1133852 CDS YP_006781268.1 407484118 13699876 complement(4762870..4764651) 1 NC_018658.1 COG4264 Siderophore synthetase component; aerobactin siderophore biosynthesis protein 4764651 13699876 O3K_23085 Escherichia coli O104:H4 str. 2011C-3493 aerobactin siderophore biosynthesis protein YP_006781268.1 4762870 R 1133852 CDS YP_006781269.1 407484119 13699877 4764730..4765923 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; membrane transport protein, major facilitator superfamily 4765923 13699877 O3K_23090 Escherichia coli O104:H4 str. 2011C-3493 membrane transport protein, major facilitator superfamily YP_006781269.1 4764730 D 1133852 CDS YP_006781270.1 407484120 13699878 4767136..4767303 1 NC_018658.1 hypothetical protein 4767303 13699878 O3K_23095 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781270.1 4767136 D 1133852 CDS YP_006781271.1 407484121 13699879 complement(4767290..4767475) 1 NC_018658.1 COG3436 Transposase and inactivated derivatives; transposase 4767475 13699879 O3K_23100 Escherichia coli O104:H4 str. 2011C-3493 transposase YP_006781271.1 4767290 R 1133852 CDS YP_006781272.1 407484122 13699880 4767539..4768579 1 NC_018658.1 COG3547 Transposase and inactivated derivatives; transposase, IS110 family protein 4768579 13699880 O3K_23105 Escherichia coli O104:H4 str. 2011C-3493 transposase, IS110 family protein YP_006781272.1 4767539 D 1133852 CDS YP_006781273.1 407484123 13699881 4769094..4769621 1 NC_018658.1 hypothetical protein 4769621 13699881 O3K_23115 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781273.1 4769094 D 1133852 CDS YP_006781274.1 407484124 13699882 complement(4769978..4770331) 1 NC_018658.1 COG3436 Transposase and inactivated derivatives; IS66 family protein; transposase ORF1, IS66 family protein 4770331 13699882 O3K_23120 Escherichia coli O104:H4 str. 2011C-3493 transposase ORF1, IS66 family protein YP_006781274.1 4769978 R 1133852 CDS YP_006781275.1 407484125 13699883 complement(4770396..4771520) 1 NC_018658.1 COG4584 Transposase and inactivated derivatives; transposase 4771520 13699883 O3K_23125 Escherichia coli O104:H4 str. 2011C-3493 transposase YP_006781275.1 4770396 R 1133852 CDS YP_006781276.1 407484126 13699884 4771741..4772250 1 NC_018658.1 COG3436 Transposase and inactivated derivatives; hypothetical protein 4772250 13699884 O3K_23130 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781276.1 4771741 D 1133852 CDS YP_006781277.1 407484127 13699885 4772313..4772531 1 NC_018658.1 COG3328 Transposase and inactivated derivatives; transposase 4772531 13699885 O3K_23135 Escherichia coli O104:H4 str. 2011C-3493 transposase YP_006781277.1 4772313 D 1133852 CDS YP_006781278.1 407484128 13699886 complement(4772682..4776800) 1 NC_018658.1 COG3468 Type V secretory pathway, adhesin AidA; Serine protease pic precursor (ShMu) 4776800 13699886 O3K_23140 Escherichia coli O104:H4 str. 2011C-3493 Serine protease pic precursor (ShMu) YP_006781278.1 4772682 R 1133852 CDS YP_006781279.1 407484129 13699887 complement(4776965..4777351) 1 NC_018658.1 COG2801 Transposase and inactivated derivatives; IS629 ORF2; transposase 4777351 13699887 O3K_23145 Escherichia coli O104:H4 str. 2011C-3493 transposase YP_006781279.1 4776965 R 1133852 CDS YP_006781280.1 407484130 13699888 complement(4777528..4779051) 1 NC_018658.1 COG3344 Retron-type reverse transcriptase; reverse transcriptase-like protein from prophage or plasmid 4779051 13699888 O3K_23150 Escherichia coli O104:H4 str. 2011C-3493 reverse transcriptase-like protein from prophage or plasmid YP_006781280.1 4777528 R 1133852 CDS YP_006781281.1 407484131 13699889 complement(4780122..4780448) 1 NC_018658.1 COG2963 Transposase and inactivated derivatives; IS629, IS3 family protein; transposase ORF A, IS629, IS3 family protein 4780448 13699889 O3K_23160 Escherichia coli O104:H4 str. 2011C-3493 transposase ORF A, IS629, IS3 family protein YP_006781281.1 4780122 R 1133852 CDS YP_006781282.1 407484132 13699890 4780972..4781445 1 NC_018658.1 antirestriction protein 4781445 13699890 O3K_23165 Escherichia coli O104:H4 str. 2011C-3493 antirestriction protein YP_006781282.1 4780972 D 1133852 CDS YP_006781283.1 407484133 13699891 4781461..4781937 1 NC_018658.1 COG2003 DNA repair proteins; RADC family DNA repair protein 4781937 13699891 O3K_23170 Escherichia coli O104:H4 str. 2011C-3493 RADC family DNA repair protein YP_006781283.1 4781461 D 1133852 CDS YP_006781284.1 407484134 13699892 4782024..4782245 1 NC_018658.1 hypothetical protein 4782245 13699892 O3K_23175 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781284.1 4782024 D 1133852 CDS YP_006781285.1 407484135 13699893 4782325..4782702 1 NC_018658.1 antitoxin of the YeeV-YeeU toxin-antitoxin system, CP4-44 prophage 4782702 13699893 O3K_23180 Escherichia coli O104:H4 str. 2011C-3493 antitoxin of the YeeV-YeeU toxin-antitoxin system, CP4-44 prophage YP_006781285.1 4782325 D 1133852 CDS YP_006781286.1 407484136 13699894 4782749..4783126 1 NC_018658.1 hypothetical protein 4783126 13699894 O3K_23185 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781286.1 4782749 D 1133852 CDS YP_006781287.1 407484137 13699895 4783123..4783611 1 NC_018658.1 hypothetical protein 4783611 13699895 O3K_23190 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781287.1 4783123 D 1133852 CDS YP_006781288.1 407484138 13699896 4783631..4783828 1 NC_018658.1 hypothetical protein 4783828 13699896 O3K_23195 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781288.1 4783631 D 1133852 CDS YP_006781289.1 407484139 13699897 4783913..4784755 1 NC_018658.1 hypothetical protein 4784755 13699897 O3K_23200 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781289.1 4783913 D 1133852 CDS YP_006781290.1 407484140 13699898 4785504..4787042 1 NC_018658.1 COG3710 DNA-binding winged-HTH domains; DNA-binding transcriptional activator CadC 4787042 13699898 O3K_23205 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional activator CadC YP_006781290.1 4785504 D 1133852 CDS YP_006781291.1 407484141 13699899 4787408..4788742 1 NC_018658.1 COG0531 Amino acid transporters; lysine/cadaverine antiporter 4788742 cadB 13699899 cadB Escherichia coli O104:H4 str. 2011C-3493 lysine/cadaverine antiporter YP_006781291.1 4787408 D 1133852 CDS YP_006781292.1 407484142 13699900 4788822..4790969 1 NC_018658.1 COG1982 Arginine/lysine/ornithine decarboxylases; lysine decarboxylase CadA 4790969 13699900 O3K_23215 Escherichia coli O104:H4 str. 2011C-3493 lysine decarboxylase CadA YP_006781292.1 4788822 D 1133852 CDS YP_006781293.1 407484143 13699901 4791028..4792485 1 NC_018658.1 COG3104 Dipeptide/tripeptide permease; transporter 4792485 13699901 O3K_23220 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006781293.1 4791028 D 1133852 CDS YP_006781294.1 407484144 13699902 4792722..4794239 1 NC_018658.1 COG1190 Lysyl-tRNA synthetase (class II); lysyl-tRNA synthetase 4794239 13699902 O3K_23225 Escherichia coli O104:H4 str. 2011C-3493 lysyl-tRNA synthetase YP_006781294.1 4792722 D 1133852 CDS YP_006781295.1 407484145 13699903 complement(4794358..4794531) 1 NC_018658.1 hypothetical protein 4794531 13699903 O3K_23230 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781295.1 4794358 R 1133852 CDS YP_006781296.1 407484146 13699904 complement(4794559..4794855) 1 NC_018658.1 hypothetical protein 4794855 13699904 O3K_23235 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781296.1 4794559 R 1133852 CDS YP_006781297.1 407484147 13699905 complement(4795082..4795354) 1 NC_018658.1 COG2388 Predicted acetyltransferase; putative acyltransferase 4795354 13699905 O3K_23240 Escherichia coli O104:H4 str. 2011C-3493 putative acyltransferase YP_006781297.1 4795082 R 1133852 CDS YP_006781298.1 407484148 13699906 complement(4795366..4795596) 1 NC_018658.1 COG3592 Uncharacterized conserved protein; hypothetical protein 4795596 13699906 O3K_23245 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781298.1 4795366 R 1133852 CDS YP_006781299.1 407484149 13699907 4795777..4797408 1 NC_018658.1 COG3290 Signal transduction histidine kinase regulating citrate/malate metabolism; sensory histidine kinase DcuS 4797408 13699907 O3K_23250 Escherichia coli O104:H4 str. 2011C-3493 sensory histidine kinase DcuS YP_006781299.1 4795777 D 1133852 CDS YP_006781300.1 407484150 13699908 4797405..4798124 1 NC_018658.1 COG4565 Response regulator of citrate/malate metabolism; DNA-binding transcriptional activator DcuR 4798124 13699908 O3K_23255 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional activator DcuR YP_006781300.1 4797405 D 1133852 CDS YP_006781301.1 407484151 13699909 4798695..4800035 1 NC_018658.1 COG2704 Anaerobic C4-dicarboxylate transporter; anaerobic C4-dicarboxylate transporter 4800035 13699909 O3K_23260 Escherichia coli O104:H4 str. 2011C-3493 anaerobic C4-dicarboxylate transporter YP_006781301.1 4798695 D 1133852 CDS YP_006781302.1 407484152 13699910 4800113..4801759 1 NC_018658.1 COG1951 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain; fumarate hydratase FumB 4801759 13699910 O3K_23265 Escherichia coli O104:H4 str. 2011C-3493 fumarate hydratase FumB YP_006781302.1 4800113 D 1133852 CDS YP_006781303.1 407484153 13699911 4801882..4802511 1 NC_018658.1 COG3647 Predicted membrane protein; hypothetical protein 4802511 13699911 O3K_23270 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781303.1 4801882 D 1133852 CDS YP_006781304.1 407484154 13699912 complement(4802650..4804059) 1 NC_018658.1 COG2211 Na+/melibiose symporter and related transporters; melibiose:sodium symporter 4804059 13699912 O3K_23275 Escherichia coli O104:H4 str. 2011C-3493 melibiose:sodium symporter YP_006781304.1 4802650 R 1133852 CDS YP_006781305.1 407484155 13699913 complement(4804174..4805529) 1 NC_018658.1 COG1486 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases; alpha-galactosidase 4805529 13699913 O3K_23280 Escherichia coli O104:H4 str. 2011C-3493 alpha-galactosidase YP_006781305.1 4804174 R 1133852 CDS YP_006781306.1 407484156 13699914 4805812..4806720 1 NC_018658.1 COG2207 AraC-type DNA-binding domain-containing proteins; DNA-binding transcriptional regulator MelR 4806720 13699914 O3K_23285 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator MelR YP_006781306.1 4805812 D 1133852 CDS YP_006781307.1 407484157 13699915 4806916..4809186 1 NC_018658.1 COG1982 Arginine/lysine/ornithine decarboxylases; arginine decarboxylase 4809186 13699915 O3K_23290 Escherichia coli O104:H4 str. 2011C-3493 arginine decarboxylase YP_006781307.1 4806916 D 1133852 CDS YP_006781308.1 407484158 13699916 4809511..4810272 1 NC_018658.1 COG2207 AraC-type DNA-binding domain-containing proteins; AraC family transcriptional regulator 4810272 13699916 O3K_23295 Escherichia coli O104:H4 str. 2011C-3493 AraC family transcriptional regulator YP_006781308.1 4809511 D 1133852 CDS YP_006781309.1 407484159 13699917 4810409..4811746 1 NC_018658.1 COG0531 Amino acid transporters; arginine:agmatin antiporter 4811746 13699917 O3K_23300 Escherichia coli O104:H4 str. 2011C-3493 arginine:agmatin antiporter YP_006781309.1 4810409 D 1133852 CDS YP_006781310.1 407484160 13699918 4811850..4813493 1 NC_018658.1 COG2194 Predicted membrane-associated, metal-dependent hydrolase; putative metal dependent hydrolase 4813493 13699918 O3K_23305 Escherichia coli O104:H4 str. 2011C-3493 putative metal dependent hydrolase YP_006781310.1 4811850 D 1133852 CDS YP_006781311.1 407484161 13699919 4813490..4814158 1 NC_018658.1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; DNA-binding transcriptional regulator BasR 4814158 13699919 O3K_23310 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator BasR YP_006781311.1 4813490 D 1133852 CDS YP_006781312.1 407484162 13699920 4814168..4815259 1 NC_018658.1 COG0642 Signal transduction histidine kinase; sensor protein BasS/PmrB 4815259 13699920 O3K_23315 Escherichia coli O104:H4 str. 2011C-3493 sensor protein BasS/PmrB YP_006781312.1 4814168 D 1133852 CDS YP_006781313.1 407484163 13699921 complement(4815436..4816938) 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; proline/glycine betaine transporter 4816938 13699921 O3K_23320 Escherichia coli O104:H4 str. 2011C-3493 proline/glycine betaine transporter YP_006781313.1 4815436 R 1133852 CDS YP_006781314.1 407484164 13699922 complement(4817202..4818080) 1 NC_018658.1 hypothetical protein 4818080 13699922 O3K_23325 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781314.1 4817202 R 1133852 CDS YP_006781315.1 407484165 13699923 complement(4818077..4820305) 1 NC_018658.1 COG0699 Predicted GTPases (dynamin-related); hypothetical protein 4820305 13699923 O3K_23330 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781315.1 4818077 R 1133852 CDS YP_006781316.1 407484166 13699924 4820707..4821042 1 NC_018658.1 COG2824 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism; putative alkylphosphonate uptake protein in phosphonate metabolism 4821042 13699924 O3K_23335 Escherichia coli O104:H4 str. 2011C-3493 putative alkylphosphonate uptake protein in phosphonate metabolism YP_006781316.1 4820707 D 1133852 CDS YP_006781317.1 407484167 13699925 4821202..4821645 1 NC_018658.1 COG2764 Uncharacterized protein conserved in bacteria; hypothetical protein 4821645 13699925 O3K_23340 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781317.1 4821202 D 1133852 CDS YP_006781318.1 407484168 13699926 4821778..4822566 1 NC_018658.1 COG3638 ABC-type phosphate/phosphonate transport system, ATPase component; phosphonate/organophosphate ester transporter subunit 4822566 13699926 O3K_23345 Escherichia coli O104:H4 str. 2011C-3493 phosphonate/organophosphate ester transporter subunit YP_006781318.1 4821778 D 1133852 CDS YP_006781319.1 407484169 13699927 4822591..4823607 1 NC_018658.1 COG3221 ABC-type phosphate/phosphonate transport system, periplasmic component; phosphonate/organophosphate ester transporter subunit PhnD 4823607 13699927 O3K_23350 Escherichia coli O104:H4 str. 2011C-3493 phosphonate/organophosphate ester transporter subunit PhnD YP_006781319.1 4822591 D 1133852 CDS YP_006781320.1 407484170 13699928 4823713..4824492 1 NC_018658.1 COG3639 ABC-type phosphate/phosphonate transport system, permease component; Pn transporter membrane channel protein 4824492 13699928 O3K_23355 Escherichia coli O104:H4 str. 2011C-3493 Pn transporter membrane channel protein YP_006781320.1 4823713 D 1133852 CDS YP_006781321.1 407484171 13699929 4824513..4825238 1 NC_018658.1 COG2188 Transcriptional regulators; phosphonate metabolism transcriptional regulator PhnF 4825238 13699929 O3K_23360 Escherichia coli O104:H4 str. 2011C-3493 phosphonate metabolism transcriptional regulator PhnF YP_006781321.1 4824513 D 1133852 CDS YP_006781322.1 407484172 13699930 4825239..4825691 1 NC_018658.1 COG3624 Uncharacterized enzyme of phosphonate metabolism; carbon-phosphorus lyase complex subunit 4825691 13699930 O3K_23365 Escherichia coli O104:H4 str. 2011C-3493 carbon-phosphorus lyase complex subunit YP_006781322.1 4825239 D 1133852 CDS YP_006781323.1 407484173 13699931 4825688..4826272 1 NC_018658.1 COG3625 Uncharacterized enzyme of phosphonate metabolism; carbon-phosphorus lyase complex subunit 4826272 phnH 13699931 phnH Escherichia coli O104:H4 str. 2011C-3493 carbon-phosphorus lyase complex subunit YP_006781323.1 4825688 D 1133852 CDS YP_006781324.1 407484174 13699932 4826272..4827336 1 NC_018658.1 COG3626 Uncharacterized enzyme of phosphonate metabolism; carbon-phosphorus lyase complex subunit 4827336 13699932 O3K_23375 Escherichia coli O104:H4 str. 2011C-3493 carbon-phosphorus lyase complex subunit YP_006781324.1 4826272 D 1133852 CDS YP_006781325.1 407484175 13699933 4827329..4828174 1 NC_018658.1 COG3627 Uncharacterized enzyme of phosphonate metabolism; carbon-phosphorus lyase complex subunit PhnJ 4828174 13699933 O3K_23380 Escherichia coli O104:H4 str. 2011C-3493 carbon-phosphorus lyase complex subunit PhnJ YP_006781325.1 4827329 D 1133852 CDS YP_006781326.1 407484176 13699934 4828171..4828929 1 NC_018658.1 COG4107 ABC-type phosphonate transport system, ATPase component; phosphonate C-P lyase system protein PhnK 4828929 phnK 13699934 phnK Escherichia coli O104:H4 str. 2011C-3493 phosphonate C-P lyase system protein PhnK YP_006781326.1 4828171 D 1133852 CDS YP_006781327.1 407484177 13699935 4829106..4829786 1 NC_018658.1 COG4778 ABC-type phosphonate transport system, ATPase component; carbon-phosphorus lyase complex subunit PhnL 4829786 13699935 O3K_23390 Escherichia coli O104:H4 str. 2011C-3493 carbon-phosphorus lyase complex subunit PhnL YP_006781327.1 4829106 D 1133852 CDS YP_006781328.1 407484178 13699936 4829783..4830919 1 NC_018658.1 COG3454 Metal-dependent hydrolase involved in phosphonate metabolism; phosphonate metabolism protein PhnM 4830919 13699936 O3K_23395 Escherichia coli O104:H4 str. 2011C-3493 phosphonate metabolism protein PhnM YP_006781328.1 4829783 D 1133852 CDS YP_006781329.1 407484179 13699937 4830919..4831476 1 NC_018658.1 COG3709 Uncharacterized component of phosphonate metabolism; ribose 1,5-bisphosphokinase 4831476 13699937 O3K_23400 Escherichia coli O104:H4 str. 2011C-3493 ribose 1,5-bisphosphokinase YP_006781329.1 4830919 D 1133852 CDS YP_006781330.1 407484180 13699938 4831463..4831897 1 NC_018658.1 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; aminoalkylphosphonic acid N-acetyltransferase 4831897 13699938 O3K_23405 Escherichia coli O104:H4 str. 2011C-3493 aminoalkylphosphonic acid N-acetyltransferase YP_006781330.1 4831463 D 1133852 CDS YP_006781331.1 407484181 13699939 4831899..4832657 1 NC_018658.1 COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I; carbon-phosphorus lyase complex accessory protein 4832657 phnP 13699939 phnP Escherichia coli O104:H4 str. 2011C-3493 carbon-phosphorus lyase complex accessory protein YP_006781331.1 4831899 D 1133852 CDS YP_006781332.1 407484182 13699940 complement(4832804..4833133) 1 NC_018658.1 hypothetical protein 4833133 13699940 O3K_23415 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781332.1 4832804 R 1133852 CDS YP_006781333.1 407484183 13699941 complement(4833202..4833519) 1 NC_018658.1 COG0698 Ribose 5-phosphate isomerase RpiB; hypothetical protein 4833519 13699941 O3K_23420 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781333.1 4833202 R 1133852 CDS YP_006781334.1 407484184 13699942 4833772..4835757 1 NC_018658.1 COG2015 Alkyl sulfatase and related hydrolases; hypothetical protein 4835757 13699942 O3K_23425 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781334.1 4833772 D 1133852 CDS YP_006781335.1 407484185 13699943 4835966..4836241 1 NC_018658.1 formate dehydrogenase H 4836241 13699943 O3K_23430 Escherichia coli O104:H4 str. 2011C-3493 formate dehydrogenase H YP_006781335.1 4835966 D 1133852 CDS YP_006781336.1 407484186 13699944 4836260..4837291 1 NC_018658.1 COG1566 Multidrug resistance efflux pump; multidrug resistance protein MdtN 4837291 13699944 O3K_23435 Escherichia coli O104:H4 str. 2011C-3493 multidrug resistance protein MdtN YP_006781336.1 4836260 D 1133852 CDS YP_006781337.1 407484187 13699945 4837291..4839342 1 NC_018658.1 COG1289 Predicted membrane protein; multidrug efflux system protein MdtO 4839342 13699945 O3K_23440 Escherichia coli O104:H4 str. 2011C-3493 multidrug efflux system protein MdtO YP_006781337.1 4837291 D 1133852 CDS YP_006781338.1 407484188 13699946 4839339..4840805 1 NC_018658.1 COG1538 Outer membrane protein; putative outer membrane efflux protein MdtP 4840805 13699946 O3K_23445 Escherichia coli O104:H4 str. 2011C-3493 putative outer membrane efflux protein MdtP YP_006781338.1 4839339 D 1133852 CDS YP_006781339.1 407484189 13699947 4841003..4841422 1 NC_018658.1 COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; formate dehydrogenase-H, selenopolypeptide subunit 4841422 13699947 O3K_23450 Escherichia coli O104:H4 str. 2011C-3493 formate dehydrogenase-H, selenopolypeptide subunit YP_006781339.1 4841003 D 1133852 CDS YP_006781340.1 407484190 13699948 4841471..4843150 1 NC_018658.1 COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; formate dehydrogenase-H, selenopolypeptide subunit 4843150 13699948 O3K_23455 Escherichia coli O104:H4 str. 2011C-3493 formate dehydrogenase-H, selenopolypeptide subunit YP_006781340.1 4841471 D 1133852 CDS YP_006781341.1 407484191 13699949 4843244..4843933 1 NC_018658.1 COG0790 FOG: TPR repeat, SEL1 subfamily; hypothetical protein 4843933 13699949 O3K_23460 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781341.1 4843244 D 1133852 CDS YP_006781342.1 407484192 13699950 complement(4844011..4845324) 1 NC_018658.1 COG1301 Na+/H+-dicarboxylate symporters; glutamate/aspartate:proton symporter 4845324 gltP 13699950 gltP Escherichia coli O104:H4 str. 2011C-3493 glutamate/aspartate:proton symporter YP_006781342.1 4844011 R 1133852 CDS YP_006781343.1 407484193 13699951 complement(4845666..4846262) 1 NC_018658.1 COG4235 Cytochrome c biogenesis factor; formate-dependent nitrite reductase complex subunit NrfG 4846262 13699951 O3K_23470 Escherichia coli O104:H4 str. 2011C-3493 formate-dependent nitrite reductase complex subunit NrfG YP_006781343.1 4845666 R 1133852 CDS YP_006781344.1 407484194 13699952 complement(4846259..4846642) 1 NC_018658.1 COG3088 Uncharacterized protein involved in biosynthesis of c-type cytochromes; formate-dependent nitrite reductase complex subunit NrfF 4846642 13699952 O3K_23475 Escherichia coli O104:H4 str. 2011C-3493 formate-dependent nitrite reductase complex subunit NrfF YP_006781344.1 4846259 R 1133852 CDS YP_006781345.1 407484195 13699953 complement(4846635..4848293) 1 NC_018658.1 COG1138 Cytochrome c biogenesis factor; heme lyase subunit NrfE 4848293 13699953 O3K_23480 Escherichia coli O104:H4 str. 2011C-3493 heme lyase subunit NrfE YP_006781345.1 4846635 R 1133852 CDS YP_006781346.1 407484196 13699954 complement(4848373..4849329) 1 NC_018658.1 COG3301 Formate-dependent nitrite reductase, membrane component; formate-dependent nitrite reductase, membrane subunit 4849329 13699954 O3K_23485 Escherichia coli O104:H4 str. 2011C-3493 formate-dependent nitrite reductase, membrane subunit YP_006781346.1 4848373 R 1133852 CDS YP_006781347.1 407484197 13699955 complement(4849326..4849997) 1 NC_018658.1 COG0437 Fe-S-cluster-containing hydrogenase components 1; formate-dependent nitrite reductase, Fe-S center 4849997 13699955 O3K_23490 Escherichia coli O104:H4 str. 2011C-3493 formate-dependent nitrite reductase, Fe-S center YP_006781347.1 4849326 R 1133852 CDS YP_006781348.1 407484198 13699956 complement(4849994..4850560) 1 NC_018658.1 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; cytochrome c nitrite reductase pentaheme subunit 4850560 13699956 O3K_23495 Escherichia coli O104:H4 str. 2011C-3493 cytochrome c nitrite reductase pentaheme subunit YP_006781348.1 4849994 R 1133852 CDS YP_006781349.1 407484199 13699957 complement(4850605..4852041) 1 NC_018658.1 COG3303 Formate-dependent nitrite reductase, periplasmic cytochrome c552 subunit; cytochrome c nitrite reductase subunit c552 4852041 nrfA 13699957 nrfA Escherichia coli O104:H4 str. 2011C-3493 cytochrome c nitrite reductase subunit c552 YP_006781349.1 4850605 R 1133852 CDS YP_006781350.1 407484200 13699958 4852433..4854391 1 NC_018658.1 COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases; acetyl-CoA synthetase 4854391 13699958 O3K_23505 Escherichia coli O104:H4 str. 2011C-3493 acetyl-CoA synthetase YP_006781350.1 4852433 D 1133852 CDS YP_006781351.1 407484201 13699959 4854591..4854905 1 NC_018658.1 COG3162 Predicted membrane protein; hypothetical protein 4854905 13699959 O3K_23510 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781351.1 4854591 D 1133852 CDS YP_006781352.1 407484202 13699960 4854902..4856551 1 NC_018658.1 COG4147 Predicted symporter; acetate permease 4856551 actP 13699960 actP Escherichia coli O104:H4 str. 2011C-3493 acetate permease YP_006781352.1 4854902 D 1133852 CDS YP_006781353.1 407484203 13699961 4856729..4858021 1 NC_018658.1 COG1357 Uncharacterized low-complexity proteins; hypothetical protein 4858021 13699961 O3K_23520 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781353.1 4856729 D 1133852 CDS YP_006781354.1 407484204 13699962 complement(4858175..4859824) 1 NC_018658.1 COG0025 NhaP-type Na+/H+ and K+/H+ antiporters; putative cation/proton antiporter 4859824 13699962 O3K_23525 Escherichia coli O104:H4 str. 2011C-3493 putative cation/proton antiporter YP_006781354.1 4858175 R 1133852 CDS YP_006781355.1 407484205 13699963 complement(4859975..4861324) 1 NC_018658.1 COG2252 Permeases; permease 4861324 13699963 O3K_23530 Escherichia coli O104:H4 str. 2011C-3493 permease YP_006781355.1 4859975 R 1133852 CDS YP_006781356.1 407484206 13699964 complement(4861870..4862334) 1 NC_018658.1 COG0789 Predicted transcriptional regulators; redox-sensitivie transcriptional activator Soxr 4862334 13699964 O3K_23535 Escherichia coli O104:H4 str. 2011C-3493 redox-sensitivie transcriptional activator Soxr YP_006781356.1 4861870 R 1133852 CDS YP_006781357.1 407484207 13699965 4862420..4862743 1 NC_018658.1 COG2207 AraC-type DNA-binding domain-containing proteins; DNA-binding transcriptional regulator SoxS 4862743 13699965 O3K_23540 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator SoxS YP_006781357.1 4862420 D 1133852 CDS YP_006781358.1 407484208 13699966 complement(4862746..4864332) 1 NC_018658.1 COG4943 Predicted signal transduction protein containing sensor and EAL domains; signal transduction protein (EAL domain containing protein) 4864332 13699966 O3K_23545 Escherichia coli O104:H4 str. 2011C-3493 signal transduction protein (EAL domain containing protein) YP_006781358.1 4862746 R 1133852 CDS YP_006781359.1 407484209 13699967 4864762..4865043 1 NC_018658.1 hypothetical protein 4865043 13699967 O3K_23550 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781359.1 4864762 D 1133852 CDS YP_006781360.1 407484210 13699968 complement(4865142..4865678) 1 NC_018658.1 COG0629 Single-stranded DNA-binding protein; single-stranded DNA-binding protein 4865678 13699968 O3K_23555 Escherichia coli O104:H4 str. 2011C-3493 single-stranded DNA-binding protein YP_006781360.1 4865142 R 1133852 CDS YP_006781361.1 407484211 13699969 4865932..4868754 1 NC_018658.1 COG0178 Excinuclease ATPase subunit; excinuclease ABC subunit A 4868754 uvrA 13699969 uvrA Escherichia coli O104:H4 str. 2011C-3493 excinuclease ABC subunit A YP_006781361.1 4865932 D 1133852 CDS YP_006781362.1 407484212 13699970 complement(4868789..4869145) 1 NC_018658.1 COG2315 Uncharacterized protein conserved in bacteria; hypothetical protein 4869145 13699970 O3K_23565 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781362.1 4868789 R 1133852 CDS YP_006781363.1 407484213 13699971 complement(4869149..4869565) 1 NC_018658.1 COG0432 Uncharacterized conserved protein; hypothetical protein 4869565 13699971 O3K_23570 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781363.1 4869149 R 1133852 CDS YP_006781364.1 407484214 13699972 complement(4869676..4870389) 1 NC_018658.1 COG3700 Acid phosphatase (class B); acid phosphatase/phosphotransferase 4870389 aphA 13699972 aphA Escherichia coli O104:H4 str. 2011C-3493 acid phosphatase/phosphotransferase YP_006781364.1 4869676 R 1133852 CDS YP_006781365.1 407484215 13699973 4870791..4871294 1 NC_018658.1 hypothetical protein 4871294 13699973 O3K_23580 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781365.1 4870791 D 1133852 CDS YP_006781366.1 407484216 13699974 complement(4871516..4872709) 1 NC_018658.1 COG1448 Aspartate/tyrosine/aromatic aminotransferase; aromatic amino acid aminotransferase 4872709 13699974 O3K_23585 Escherichia coli O104:H4 str. 2011C-3493 aromatic amino acid aminotransferase YP_006781366.1 4871516 R 1133852 CDS YP_006781367.1 407484217 13699975 complement(4872962..4874041) 1 NC_018658.1 COG0787 Alanine racemase; alanine racemase 4874041 alr 13699975 alr Escherichia coli O104:H4 str. 2011C-3493 alanine racemase YP_006781367.1 4872962 R 1133852 CDS YP_006781368.1 407484218 13699976 complement(4874094..4875509) 1 NC_018658.1 COG0305 Replicative DNA helicase; replicative DNA helicase 4875509 13699976 O3K_23595 Escherichia coli O104:H4 str. 2011C-3493 replicative DNA helicase YP_006781368.1 4874094 R 1133852 CDS YP_006781369.1 407484219 13699977 4875592..4876575 1 NC_018658.1 COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases; quinone oxidoreductase 4876575 13699977 O3K_23600 Escherichia coli O104:H4 str. 2011C-3493 quinone oxidoreductase YP_006781369.1 4875592 D 1133852 CDS YP_006781370.1 407484220 13699978 complement(4876741..4876983) 1 NC_018658.1 phage shock protein G 4876983 pspG 13699978 pspG Escherichia coli O104:H4 str. 2011C-3493 phage shock protein G YP_006781370.1 4876741 R 1133852 CDS YP_006781371.1 407484221 13699979 complement(4877117..4878136) 1 NC_018658.1 COG0042 tRNA-dihydrouridine synthase; tRNA-dihydrouridine synthase A 4878136 13699979 O3K_23610 Escherichia coli O104:H4 str. 2011C-3493 tRNA-dihydrouridine synthase A YP_006781371.1 4877117 R 1133852 CDS YP_006781372.1 407484222 13699980 complement(4878518..4879231) 1 NC_018658.1 hypothetical protein 4879231 13699980 O3K_23615 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781372.1 4878518 R 1133852 CDS YP_006781373.1 407484223 13699981 complement(4879255..4879509) 1 NC_018658.1 hypothetical protein 4879509 13699981 O3K_23620 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781373.1 4879255 R 1133852 CDS YP_006781374.1 407484224 13699982 4879827..4880342 1 NC_018658.1 COG0735 Fe2+/Zn2+ uptake regulation proteins; zinc uptake transcriptional repressor 4880342 13699982 O3K_23625 Escherichia coli O104:H4 str. 2011C-3493 zinc uptake transcriptional repressor YP_006781374.1 4879827 D 1133852 CDS YP_006781375.1 407484225 13699983 complement(4880384..4880593) 1 NC_018658.1 COG3237 Uncharacterized protein conserved in bacteria; hypothetical protein 4880593 13699983 O3K_23630 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781375.1 4880384 R 1133852 CDS YP_006781376.1 407484226 13699984 complement(4880689..4882035) 1 NC_018658.1 COG0534 Na+-driven multidrug efflux pump; DNA-damage-inducible SOS response protein 4882035 13699984 O3K_23635 Escherichia coli O104:H4 str. 2011C-3493 DNA-damage-inducible SOS response protein YP_006781376.1 4880689 R 1133852 CDS YP_006781377.1 407484227 13699985 complement(4882108..4882716) 1 NC_018658.1 COG1974 SOS-response transcriptional repressors (RecA-mediated autopeptidases); LexA repressor 4882716 13699985 O3K_23640 Escherichia coli O104:H4 str. 2011C-3493 LexA repressor YP_006781377.1 4882108 R 1133852 CDS YP_006781378.1 407484228 13699986 complement(4882826..4883194) 1 NC_018658.1 COG0818 Diacylglycerol kinase; diacylglycerol kinase 4883194 13699986 O3K_23645 Escherichia coli O104:H4 str. 2011C-3493 diacylglycerol kinase YP_006781378.1 4882826 R 1133852 CDS YP_006781379.1 407484229 13699987 4883365..4885788 1 NC_018658.1 COG2937 Glycerol-3-phosphate O-acyltransferase; glycerol-3-phosphate acyltransferase 4885788 13699987 O3K_23650 Escherichia coli O104:H4 str. 2011C-3493 glycerol-3-phosphate acyltransferase YP_006781379.1 4883365 D 1133852 CDS YP_006781380.1 407484230 13699988 complement(4885943..4886815) 1 NC_018658.1 COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases; 4-hydroxybenzoate octaprenyltransferase 4886815 ubiA 13699988 ubiA Escherichia coli O104:H4 str. 2011C-3493 4-hydroxybenzoate octaprenyltransferase YP_006781380.1 4885943 R 1133852 CDS YP_006781381.1 407484231 13699989 complement(4886828..4887325) 1 NC_018658.1 COG3161 4-hydroxybenzoate synthetase (chorismate lyase); chorismate pyruvate lyase 4887325 ubiC 13699989 ubiC Escherichia coli O104:H4 str. 2011C-3493 chorismate pyruvate lyase YP_006781381.1 4886828 R 1133852 CDS YP_006781382.1 407484232 13699990 complement(4887548..4888876) 1 NC_018658.1 COG1357 Uncharacterized low-complexity proteins; hypothetical protein 4888876 13699990 O3K_23665 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781382.1 4887548 R 1133852 CDS YP_006781383.1 407484233 13699991 complement(4888934..4889128) 1 NC_018658.1 hypothetical protein 4889128 13699991 O3K_23670 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781383.1 4888934 R 1133852 CDS YP_006781384.1 407484234 13699992 complement(4889357..4890277) 1 NC_018658.1 maltose regulon periplasmic protein 4890277 13699992 O3K_23675 Escherichia coli O104:H4 str. 2011C-3493 maltose regulon periplasmic protein YP_006781384.1 4889357 R 1133852 CDS YP_006781385.1 407484235 13699993 complement(4890429..4891769) 1 NC_018658.1 COG4580 Maltoporin (phage lambda and maltose receptor); maltoporin 4891769 lamB 13699993 lamB Escherichia coli O104:H4 str. 2011C-3493 maltoporin YP_006781385.1 4890429 R 1133852 CDS YP_006781386.1 407484236 13699994 complement(4891841..4892956) 1 NC_018658.1 COG3839 ABC-type sugar transport systems, ATPase components; maltose/maltodextrin transporter ATP-binding protein 4892956 13699994 O3K_23685 Escherichia coli O104:H4 str. 2011C-3493 maltose/maltodextrin transporter ATP-binding protein YP_006781386.1 4891841 R 1133852 CDS YP_006781387.1 407484237 13699995 4893133..4893228 1 NC_018658.1 hypothetical protein 4893228 13699995 O3K_23690 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781387.1 4893133 D 1133852 CDS YP_006781388.1 407484238 13699996 4893321..4894511 1 NC_018658.1 COG2182 Maltose-binding periplasmic proteins/domains; maltose ABC transporter substrate-binding protein 4894511 malE 13699996 malE Escherichia coli O104:H4 str. 2011C-3493 maltose ABC transporter substrate-binding protein YP_006781388.1 4893321 D 1133852 CDS YP_006781389.1 407484239 13699997 4894665..4896209 1 NC_018658.1 COG1175 ABC-type sugar transport systems, permease components; maltose transporter membrane protein 4896209 malF 13699997 malF Escherichia coli O104:H4 str. 2011C-3493 maltose transporter membrane protein YP_006781389.1 4894665 D 1133852 CDS YP_006781390.1 407484240 13699998 4896224..4897114 1 NC_018658.1 COG3833 ABC-type maltose transport systems, permease component; maltose transporter permease 4897114 malG 13699998 malG Escherichia coli O104:H4 str. 2011C-3493 maltose transporter permease YP_006781390.1 4896224 D 1133852 CDS YP_006781391.1 407484241 13699999 4897486..4898961 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; D-xylose transporter XylE 4898961 xylE 13699999 xylE Escherichia coli O104:H4 str. 2011C-3493 D-xylose transporter XylE YP_006781391.1 4897486 D 1133852 CDS YP_006781392.1 407484242 13700000 complement(4899005..4899415) 1 NC_018658.1 COG3223 Predicted membrane protein; phosphate-starvation-inducible protein PsiE 4899415 13700000 O3K_23715 Escherichia coli O104:H4 str. 2011C-3493 phosphate-starvation-inducible protein PsiE YP_006781392.1 4899005 R 1133852 CDS YP_006781393.1 407484243 13700001 complement(4899541..4899684) 1 NC_018658.1 hypothetical protein 4899684 13700001 O3K_23720 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781393.1 4899541 R 1133852 CDS YP_006781394.1 407484244 13700002 complement(4900010..4902106) 1 NC_018658.1 porin 4902106 13700002 O3K_23725 Escherichia coli O104:H4 str. 2011C-3493 porin YP_006781394.1 4900010 R 1133852 CDS YP_006781395.1 407484245 13700003 complement(4902106..4902843) 1 NC_018658.1 hypothetical protein 4902843 13700003 O3K_23730 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781395.1 4902106 R 1133852 CDS YP_006781396.1 407484246 13700004 complement(4902840..4903478) 1 NC_018658.1 hypothetical protein 4903478 13700004 O3K_23735 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781396.1 4902840 R 1133852 CDS YP_006781397.1 407484247 13700005 complement(4904189..4905838) 1 NC_018658.1 COG0166 Glucose-6-phosphate isomerase; glucose-6-phosphate isomerase 4905838 pgi 13700005 pgi Escherichia coli O104:H4 str. 2011C-3493 glucose-6-phosphate isomerase YP_006781397.1 4904189 R 1133852 CDS YP_006781398.1 407484248 13700006 4906363..4907712 1 NC_018658.1 COG0527 Aspartokinases; aspartate kinase III 4907712 13700006 O3K_23745 Escherichia coli O104:H4 str. 2011C-3493 aspartate kinase III YP_006781398.1 4906363 D 1133852 CDS YP_006781399.1 407484249 13700007 4907857..4908783 1 NC_018658.1 COG0464 ATPases of the AAA+ class; hypothetical protein 4908783 13700007 O3K_23750 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781399.1 4907857 D 1133852 CDS YP_006781400.1 407484250 13700008 complement(4908819..4909583) 1 NC_018658.1 COG3541 Predicted nucleotidyltransferase; hypothetical protein 4909583 13700008 O3K_23755 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781400.1 4908819 R 1133852 CDS YP_006781401.1 407484251 13700009 complement(4909616..4910743) 1 NC_018658.1 COG0330 Membrane protease subunits, stomatin/prohibitin homologs; hypothetical protein 4910743 13700009 O3K_23760 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781401.1 4909616 R 1133852 CDS YP_006781402.1 407484252 13700010 4911272..4911544 1 NC_018658.1 hypothetical protein 4911544 13700010 O3K_23765 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781402.1 4911272 D 1133852 CDS YP_006781403.1 407484253 13700011 complement(4911545..4912417) 1 NC_018658.1 COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases; 23S rRNA pseudouridine synthase F 4912417 13700011 O3K_23770 Escherichia coli O104:H4 str. 2011C-3493 23S rRNA pseudouridine synthase F YP_006781403.1 4911545 R 1133852 CDS YP_006781404.1 407484254 13700012 4912629..4913318 1 NC_018658.1 COG3340 Peptidase E; (alpha)-aspartyl dipeptidase 4913318 13700012 O3K_23775 Escherichia coli O104:H4 str. 2011C-3493 (alpha)-aspartyl dipeptidase YP_006781404.1 4912629 D 1133852 CDS YP_006781405.1 407484255 13700013 complement(4913409..4915040) 1 NC_018658.1 COG1283 Na+/phosphate symporter; transporter 4915040 13700013 O3K_23780 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006781405.1 4913409 R 1133852 CDS YP_006781406.1 407484256 13700014 complement(4915260..4918943) 1 NC_018658.1 COG0646 Methionine synthase I (cobalamin-dependent), methyltransferase domain; B12-dependent methionine synthase 4918943 metH 13700014 metH Escherichia coli O104:H4 str. 2011C-3493 B12-dependent methionine synthase YP_006781406.1 4915260 R 1133852 CDS YP_006781407.1 407484257 13700015 4919143..4919967 1 NC_018658.1 COG1414 Transcriptional regulator; IclR family transcriptional regulator 4919967 13700015 O3K_23790 Escherichia coli O104:H4 str. 2011C-3493 IclR family transcriptional regulator YP_006781407.1 4919143 D 1133852 CDS YP_006781408.1 407484258 13700016 4920284..4921858 1 NC_018658.1 ShET2 enterotoxin domain-containing protein 4921858 13700016 O3K_23795 Escherichia coli O104:H4 str. 2011C-3493 ShET2 enterotoxin domain-containing protein YP_006781408.1 4920284 D 1133852 CDS YP_006781409.1 407484259 13700017 complement(4921827..4923563) 1 NC_018658.1 COG4579 Isocitrate dehydrogenase kinase/phosphatase; bifunctional isocitrate dehydrogenase kinase/phosphatase 4923563 aceK 13700017 aceK Escherichia coli O104:H4 str. 2011C-3493 bifunctional isocitrate dehydrogenase kinase/phosphatase YP_006781409.1 4921827 R 1133852 CDS YP_006781410.1 407484260 13700018 complement(4923844..4925148) 1 NC_018658.1 COG2224 Isocitrate lyase; isocitrate lyase 4925148 13700018 O3K_23805 Escherichia coli O104:H4 str. 2011C-3493 isocitrate lyase YP_006781410.1 4923844 R 1133852 CDS YP_006781411.1 407484261 13700019 complement(4925178..4926779) 1 NC_018658.1 COG2225 Malate synthase; malate synthase 4926779 13700019 O3K_23810 Escherichia coli O104:H4 str. 2011C-3493 malate synthase YP_006781411.1 4925178 R 1133852 CDS YP_006781412.1 407484262 13700020 complement(4927048..4927977) 1 NC_018658.1 COG1897 Homoserine trans-succinylase; homoserine O-succinyltransferase 4927977 13700020 O3K_23815 Escherichia coli O104:H4 str. 2011C-3493 homoserine O-succinyltransferase YP_006781412.1 4927048 R 1133852 CDS YP_006781413.1 407484263 13700021 4928134..4928577 1 NC_018658.1 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; acetyltransferase 4928577 13700021 O3K_23820 Escherichia coli O104:H4 str. 2011C-3493 acetyltransferase YP_006781413.1 4928134 D 1133852 CDS YP_006781414.1 407484264 13700027 4934411..4936000 1 NC_018658.1 COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 4936000 purH 13700027 purH Escherichia coli O104:H4 str. 2011C-3493 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase YP_006781414.1 4934411 D 1133852 CDS YP_006781415.1 407484265 13700028 4936012..4937301 1 NC_018658.1 COG0151 Phosphoribosylamine-glycine ligase; phosphoribosylamine--glycine ligase 4937301 13700028 O3K_23830 Escherichia coli O104:H4 str. 2011C-3493 phosphoribosylamine--glycine ligase YP_006781415.1 4936012 D 1133852 CDS YP_006781416.1 407484266 13700029 complement(4937298..4938623) 1 NC_018658.1 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains; transcriptional regulatory protein ZraR 4938623 13700029 O3K_23835 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulatory protein ZraR YP_006781416.1 4937298 R 1133852 CDS YP_006781417.1 407484267 13700030 complement(4938620..4939996) 1 NC_018658.1 COG0642 Signal transduction histidine kinase; sensor protein ZraS 4939996 13700030 O3K_23840 Escherichia coli O104:H4 str. 2011C-3493 sensor protein ZraS YP_006781417.1 4938620 R 1133852 CDS YP_006781418.1 407484268 13700031 4940234..4940659 1 NC_018658.1 COG3678 P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein; zinc resistance protein 4940659 zraP 13700031 zraP Escherichia coli O104:H4 str. 2011C-3493 zinc resistance protein YP_006781418.1 4940234 D 1133852 CDS YP_006781419.1 407484269 13700032 complement(4940661..4941356) 1 NC_018658.1 hypothetical protein 4941356 13700032 O3K_23850 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781419.1 4940661 R 1133852 CDS YP_006781420.1 407484270 13700033 complement(4941369..4941641) 1 NC_018658.1 COG0776 Bacterial nucleoid DNA-binding protein; transcriptional regulator HU subunit alpha 4941641 13700033 O3K_23855 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator HU subunit alpha YP_006781420.1 4941369 R 1133852 CDS YP_006781421.1 407484271 13700034 complement(4941828..4942418) 1 NC_018658.1 COG3068 Uncharacterized protein conserved in bacteria; hypothetical protein 4942418 13700034 O3K_23860 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781421.1 4941828 R 1133852 CDS YP_006781422.1 407484272 13700035 complement(4942461..4943132) 1 NC_018658.1 COG1515 Deoxyinosine 3'endonuclease (endonuclease V); endonuclease V 4943132 13700035 O3K_23865 Escherichia coli O104:H4 str. 2011C-3493 endonuclease V YP_006781422.1 4942461 R 1133852 CDS YP_006781423.1 407484273 13700036 complement(4943142..4944206) 1 NC_018658.1 COG0407 Uroporphyrinogen-III decarboxylase; uroporphyrinogen decarboxylase 4944206 hemE 13700036 hemE Escherichia coli O104:H4 str. 2011C-3493 uroporphyrinogen decarboxylase YP_006781423.1 4943142 R 1133852 CDS YP_006781424.1 407484274 13700037 complement(4944246..4945019) 1 NC_018658.1 COG2816 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding; NADH pyrophosphatase 4945019 nudC 13700037 nudC Escherichia coli O104:H4 str. 2011C-3493 NADH pyrophosphatase YP_006781424.1 4944246 R 1133852 CDS YP_006781425.1 407484275 13700038 4945114..4945590 1 NC_018658.1 COG3160 Regulator of sigma D; anti-RNA polymerase sigma 70 factor 4945590 13700038 O3K_23880 Escherichia coli O104:H4 str. 2011C-3493 anti-RNA polymerase sigma 70 factor YP_006781425.1 4945114 D 1133852 CDS YP_006781426.1 407484276 13700039 4945823..4947718 1 NC_018658.1 COG0422 Thiamine biosynthesis protein ThiC; thiamine biosynthesis protein ThiC 4947718 13700039 O3K_23885 Escherichia coli O104:H4 str. 2011C-3493 thiamine biosynthesis protein ThiC YP_006781426.1 4945823 D 1133852 CDS YP_006781427.1 407484277 13700040 4947718..4948353 1 NC_018658.1 COG0352 Thiamine monophosphate synthase; thiamine-phosphate pyrophosphorylase 4948353 13700040 O3K_23890 Escherichia coli O104:H4 str. 2011C-3493 thiamine-phosphate pyrophosphorylase YP_006781427.1 4947718 D 1133852 CDS YP_006781428.1 407484278 13700041 4948346..4949101 1 NC_018658.1 COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2; thiamin biosynthesis protein ThiF 4949101 13700041 O3K_23895 Escherichia coli O104:H4 str. 2011C-3493 thiamin biosynthesis protein ThiF YP_006781428.1 4948346 D 1133852 CDS YP_006781429.1 407484279 13700042 4949085..4949285 1 NC_018658.1 COG2104 Sulfur transfer protein involved in thiamine biosynthesis; sulfur carrier protein ThiS 4949285 13700042 O3K_23900 Escherichia coli O104:H4 str. 2011C-3493 sulfur carrier protein ThiS YP_006781429.1 4949085 D 1133852 CDS YP_006781430.1 407484280 13700043 4949287..4950057 1 NC_018658.1 COG2022 Uncharacterized enzyme of thiazole biosynthesis; thiazole synthase 4950057 thiG 13700043 thiG Escherichia coli O104:H4 str. 2011C-3493 thiazole synthase YP_006781430.1 4949287 D 1133852 CDS YP_006781431.1 407484281 13700044 4950054..4951187 1 NC_018658.1 COG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes; thiamine biosynthesis protein ThiH 4951187 thiH 13700044 thiH Escherichia coli O104:H4 str. 2011C-3493 thiamine biosynthesis protein ThiH YP_006781431.1 4950054 D 1133852 CDS YP_006781432.1 407484282 13700045 complement(4951597..4952136) 1 NC_018658.1 stationary phase growth adaptation protein 4952136 13700045 O3K_23915 Escherichia coli O104:H4 str. 2011C-3493 stationary phase growth adaptation protein YP_006781432.1 4951597 R 1133852 CDS YP_006781433.1 407484283 13700046 complement(4952349..4956572) 1 NC_018658.1 COG0086 DNA-directed RNA polymerase, beta' subunit/160 kD subunit; DNA-directed RNA polymerase subunit beta' 4956572 13700046 O3K_23920 Escherichia coli O104:H4 str. 2011C-3493 DNA-directed RNA polymerase subunit beta' YP_006781433.1 4952349 R 1133852 CDS YP_006781434.1 407484284 13700047 complement(4956649..4960677) 1 NC_018658.1 COG0085 DNA-directed RNA polymerase, beta subunit/140 kD subunit; DNA-directed RNA polymerase subunit beta 4960677 rpoB 13700047 rpoB Escherichia coli O104:H4 str. 2011C-3493 DNA-directed RNA polymerase subunit beta YP_006781434.1 4956649 R 1133852 CDS YP_006781435.1 407484285 13700048 complement(4960997..4961362) 1 NC_018658.1 COG0222 Ribosomal protein L7/L12; 50S ribosomal protein L7/L12 4961362 rplL 13700048 rplL Escherichia coli O104:H4 str. 2011C-3493 50S ribosomal protein L7/L12 YP_006781435.1 4960997 R 1133852 CDS YP_006781436.1 407484286 13700049 complement(4961429..4961926) 1 NC_018658.1 COG0244 Ribosomal protein L10; 50S ribosomal protein L10 4961926 rplJ 13700049 rplJ Escherichia coli O104:H4 str. 2011C-3493 50S ribosomal protein L10 YP_006781436.1 4961429 R 1133852 CDS YP_006781437.1 407484287 13700050 complement(4962339..4963043) 1 NC_018658.1 COG0081 Ribosomal protein L1; 50S ribosomal protein L1 4963043 rplA 13700050 rplA Escherichia coli O104:H4 str. 2011C-3493 50S ribosomal protein L1 YP_006781437.1 4962339 R 1133852 CDS YP_006781438.1 407484288 13700051 complement(4963047..4963475) 1 NC_018658.1 COG0080 Ribosomal protein L11; 50S ribosomal protein L11 4963475 rplK 13700051 rplK Escherichia coli O104:H4 str. 2011C-3493 50S ribosomal protein L11 YP_006781438.1 4963047 R 1133852 CDS YP_006781439.1 407484289 13700052 complement(4963634..4964179) 1 NC_018658.1 COG0250 Transcription antiterminator; transcription antitermination protein NusG 4964179 nusG 13700052 nusG Escherichia coli O104:H4 str. 2011C-3493 transcription antitermination protein NusG YP_006781439.1 4963634 R 1133852 CDS YP_006781440.1 407484290 13700053 complement(4964181..4964564) 1 NC_018658.1 COG0690 Preprotein translocase subunit SecE; preprotein translocase subunit SecE 4964564 secE 13700053 secE Escherichia coli O104:H4 str. 2011C-3493 preprotein translocase subunit SecE YP_006781440.1 4964181 R 1133852 CDS YP_006781441.1 407484291 13700054 complement(4964794..4965978) 1 NC_018658.1 COG0050 GTPases - translation elongation factors; elongation factor Tu 4965978 13700054 O3K_23960 Escherichia coli O104:H4 str. 2011C-3493 elongation factor Tu YP_006781441.1 4964794 R 1133852 CDS YP_006781442.1 407484292 13700059 4966896..4967846 1 NC_018658.1 COG1072 Panthothenate kinase; pantothenate kinase 4967846 13700059 O3K_23970 Escherichia coli O104:H4 str. 2011C-3493 pantothenate kinase YP_006781442.1 4966896 D 1133852 CDS YP_006781443.1 407484293 13700060 complement(4967875..4968840) 1 NC_018658.1 COG1654 Biotin operon repressor; bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor 4968840 13700060 O3K_23975 Escherichia coli O104:H4 str. 2011C-3493 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor YP_006781443.1 4967875 R 1133852 CDS YP_006781444.1 407484294 13700061 complement(4968837..4969865) 1 NC_018658.1 COG0812 UDP-N-acetylmuramate dehydrogenase; UDP-N-acetylenolpyruvoylglucosamine reductase 4969865 murB 13700061 murB Escherichia coli O104:H4 str. 2011C-3493 UDP-N-acetylenolpyruvoylglucosamine reductase YP_006781444.1 4968837 R 1133852 CDS YP_006781445.1 407484295 13700067 complement(4975644..4976501) 1 NC_018658.1 COG0796 Glutamate racemase; glutamate racemase 4976501 13700067 O3K_23985 Escherichia coli O104:H4 str. 2011C-3493 glutamate racemase YP_006781445.1 4975644 R 1133852 CDS YP_006781446.1 407484296 13700068 complement(4976446..4978290) 1 NC_018658.1 COG4206 Outer membrane cobalamin receptor protein; vitamin B12/cobalamin outer membrane transporter 4978290 btuB 13700068 btuB Escherichia coli O104:H4 str. 2011C-3493 vitamin B12/cobalamin outer membrane transporter YP_006781446.1 4976446 R 1133852 CDS YP_006781447.1 407484297 13700069 4978659..4979759 1 NC_018658.1 COG2265 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase; tRNA (uracil-5-)-methyltransferase 4979759 13700069 O3K_23995 Escherichia coli O104:H4 str. 2011C-3493 tRNA (uracil-5-)-methyltransferase YP_006781447.1 4978659 D 1133852 CDS YP_006781448.1 407484298 13700070 complement(4979799..4980158) 1 NC_018658.1 hypothetical protein 4980158 13700070 O3K_24000 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781448.1 4979799 R 1133852 CDS YP_006781449.1 407484299 13700071 complement(4980158..4980862) 1 NC_018658.1 COG1309 Transcriptional regulator; DNA-binding transcriptional repressor FabR 4980862 13700071 O3K_24005 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional repressor FabR YP_006781449.1 4980158 R 1133852 CDS YP_006781450.1 407484300 13700072 4981139..4982539 1 NC_018658.1 COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes; soluble pyridine nucleotide transhydrogenase 4982539 13700072 O3K_24010 Escherichia coli O104:H4 str. 2011C-3493 soluble pyridine nucleotide transhydrogenase YP_006781450.1 4981139 D 1133852 CDS YP_006781451.1 407484301 13700073 complement(4982522..4983439) 1 NC_018658.1 COG0583 Transcriptional regulator; DNA-binding transcriptional regulator OxyR 4983439 13700073 O3K_24015 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator OxyR YP_006781451.1 4982522 R 1133852 CDS YP_006781452.1 407484302 13700074 complement(4983690..4984973) 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; transporter 4984973 13700074 O3K_24020 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006781452.1 4983690 R 1133852 CDS YP_006781453.1 407484303 13700075 complement(4985040..4986254) 1 NC_018658.1 COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily; bifunctional D-altronate/D-mannonate dehydratase 4986254 13700075 O3K_24025 Escherichia coli O104:H4 str. 2011C-3493 bifunctional D-altronate/D-mannonate dehydratase YP_006781453.1 4985040 R 1133852 CDS YP_006781454.1 407484304 13700076 complement(4986752..4988125) 1 NC_018658.1 COG0165 Argininosuccinate lyase; argininosuccinate lyase 4988125 13700076 O3K_24030 Escherichia coli O104:H4 str. 2011C-3493 argininosuccinate lyase YP_006781454.1 4986752 R 1133852 CDS YP_006781455.1 407484305 13700077 complement(4988186..4988959) 1 NC_018658.1 COG0548 Acetylglutamate kinase; acetylglutamate kinase 4988959 13700077 O3K_24035 Escherichia coli O104:H4 str. 2011C-3493 acetylglutamate kinase YP_006781455.1 4988186 R 1133852 CDS YP_006781456.1 407484306 13700078 complement(4988970..4989974) 1 NC_018658.1 COG0002 Acetylglutamate semialdehyde dehydrogenase; N-acetyl-gamma-glutamyl-phosphate reductase 4989974 argC 13700078 argC Escherichia coli O104:H4 str. 2011C-3493 N-acetyl-gamma-glutamyl-phosphate reductase YP_006781456.1 4988970 R 1133852 CDS YP_006781457.1 407484307 13700079 4990128..4991279 1 NC_018658.1 COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases; acetylornithine deacetylase 4991279 13700079 O3K_24045 Escherichia coli O104:H4 str. 2011C-3493 acetylornithine deacetylase YP_006781457.1 4990128 D 1133852 CDS YP_006781458.1 407484308 13700080 4991631..4994282 1 NC_018658.1 COG2352 Phosphoenolpyruvate carboxylase; phosphoenolpyruvate carboxylase 4994282 13700080 O3K_24050 Escherichia coli O104:H4 str. 2011C-3493 phosphoenolpyruvate carboxylase YP_006781458.1 4991631 D 1133852 CDS YP_006781459.1 407484309 13700081 4994465..4996198 1 NC_018658.1 COG2194 Predicted membrane-associated, metal-dependent hydrolase; hypothetical protein 4996198 13700081 O3K_24055 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781459.1 4994465 D 1133852 CDS YP_006781460.1 407484310 13700082 4996413..4997264 1 NC_018658.1 COG2207 AraC-type DNA-binding domain-containing proteins; DNA-binding transcriptional regulator 4997264 13700082 O3K_24060 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator YP_006781460.1 4996413 D 1133852 CDS YP_006781461.1 407484311 13700083 complement(4997251..4997592) 1 NC_018658.1 COG1445 Phosphotransferase system fructose-specific component IIB; PTS system fructose-like transporter subunit EIIB 4997592 13700083 O3K_24065 Escherichia coli O104:H4 str. 2011C-3493 PTS system fructose-like transporter subunit EIIB YP_006781461.1 4997251 R 1133852 CDS YP_006781462.1 407484312 13700084 complement(4997594..4998472) 1 NC_018658.1 COG1180 Pyruvate-formate lyase-activating enzyme; pyruvate formate lyase II activase 4998472 13700084 O3K_24070 Escherichia coli O104:H4 str. 2011C-3493 pyruvate formate lyase II activase YP_006781462.1 4997594 R 1133852 CDS YP_006781463.1 407484313 13700085 complement(4998438..5000735) 1 NC_018658.1 COG1882 Pyruvate-formate lyase; putative formate acetyltransferase 2 5000735 pflD 13700085 pflD Escherichia coli O104:H4 str. 2011C-3493 putative formate acetyltransferase 2 YP_006781463.1 4998438 R 1133852 CDS YP_006781464.1 407484314 13700086 complement(5000786..5001106) 1 NC_018658.1 COG1445 Phosphotransferase system fructose-specific component IIB; PTS system fructose-like transporter subunit EIIB 5001106 13700086 O3K_24080 Escherichia coli O104:H4 str. 2011C-3493 PTS system fructose-like transporter subunit EIIB YP_006781464.1 5000786 R 1133852 CDS YP_006781465.1 407484315 13700087 complement(5001121..5002200) 1 NC_018658.1 COG1299 Phosphotransferase system, fructose-specific IIC component; PTS system fructose-like transporter subunit IIC 5002200 13700087 O3K_24085 Escherichia coli O104:H4 str. 2011C-3493 PTS system fructose-like transporter subunit IIC YP_006781465.1 5001121 R 1133852 CDS YP_006781466.1 407484316 13700088 5002509..5005010 1 NC_018658.1 COG1925 Phosphotransferase system, HPr-related proteins; PTS system transporter proteins Hpr/EI/IIA 5005010 13700088 O3K_24090 Escherichia coli O104:H4 str. 2011C-3493 PTS system transporter proteins Hpr/EI/IIA YP_006781466.1 5002509 D 1133852 CDS YP_006781467.1 407484317 13700089 5005022..5005684 1 NC_018658.1 COG0176 Transaldolase; fructose-6-phosphate aldolase 5005684 13700089 O3K_24095 Escherichia coli O104:H4 str. 2011C-3493 fructose-6-phosphate aldolase YP_006781467.1 5005022 D 1133852 CDS YP_006781468.1 407484318 13700090 5005695..5006798 1 NC_018658.1 COG0371 Glycerol dehydrogenase and related enzymes; glycerol dehydrogenase 5006798 gldA 13700090 gldA Escherichia coli O104:H4 str. 2011C-3493 glycerol dehydrogenase YP_006781468.1 5005695 D 1133852 CDS YP_006781469.1 407484319 13700091 5006830..5006961 1 NC_018658.1 hypothetical protein 5006961 13700091 O3K_24105 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781469.1 5006830 D 1133852 CDS YP_006781470.1 407484320 13700092 5007073..5007690 1 NC_018658.1 COG3738 Uncharacterized protein conserved in bacteria; hypothetical protein 5007690 13700092 O3K_24110 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781470.1 5007073 D 1133852 CDS YP_006781471.1 407484321 13700093 complement(5007717..5008622) 1 NC_018658.1 COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; hypothetical protein 5008622 13700093 O3K_24115 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781471.1 5007717 R 1133852 CDS YP_006781472.1 407484322 13700094 complement(5008716..5010896) 1 NC_018658.1 COG0376 Catalase (peroxidase I); catalase/hydroperoxidase HPI(I) 5010896 13700094 O3K_24120 Escherichia coli O104:H4 str. 2011C-3493 catalase/hydroperoxidase HPI(I) YP_006781472.1 5008716 R 1133852 CDS YP_006781473.1 407484323 13700095 complement(5011225..5012115) 1 NC_018658.1 COG0685 5,10-methylenetetrahydrofolate reductase; 5,10-methylenetetrahydrofolate reductase 5012115 metF 13700095 metF Escherichia coli O104:H4 str. 2011C-3493 5,10-methylenetetrahydrofolate reductase YP_006781473.1 5011225 R 1133852 CDS YP_006781474.1 407484324 13700096 5012191..5012325 1 NC_018658.1 hypothetical protein 5012325 13700096 O3K_24130 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781474.1 5012191 D 1133852 CDS YP_006781475.1 407484325 13700097 complement(5012464..5014896) 1 NC_018658.1 COG0527 Aspartokinases; bifunctional aspartate kinase II/homoserine dehydrogenase II 5014896 metL 13700097 metL Escherichia coli O104:H4 str. 2011C-3493 bifunctional aspartate kinase II/homoserine dehydrogenase II YP_006781475.1 5012464 R 1133852 CDS YP_006781476.1 407484326 13700098 complement(5014899..5016059) 1 NC_018658.1 COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases; cystathionine gamma-synthase 5016059 13700098 O3K_24140 Escherichia coli O104:H4 str. 2011C-3493 cystathionine gamma-synthase YP_006781476.1 5014899 R 1133852 CDS YP_006781477.1 407484327 13700099 5016336..5016653 1 NC_018658.1 COG3060 Transcriptional regulator of met regulon; transcriptional repressor protein MetJ 5016653 13700099 O3K_24145 Escherichia coli O104:H4 str. 2011C-3493 transcriptional repressor protein MetJ YP_006781477.1 5016336 D 1133852 CDS YP_006781478.1 407484328 13700100 5017465..5017737 1 NC_018658.1 COG3677 Transposase and inactivated derivatives; hypothetical protein 5017737 13700100 O3K_24160 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781478.1 5017465 D 1133852 CDS YP_006781479.1 407484329 13700101 5017764..5017949 1 NC_018658.1 COG1662 Transposase and inactivated derivatives, IS1 family; transposase 5017949 13700101 O3K_24165 Escherichia coli O104:H4 str. 2011C-3493 transposase YP_006781479.1 5017764 D 1133852 CDS YP_006781480.1 407484330 13700102 5017943..5018257 1 NC_018658.1 COG1662 Transposase and inactivated derivatives, IS1 family; iso-IS1 InsB protein, transposase 5018257 13700102 O3K_24170 Escherichia coli O104:H4 str. 2011C-3493 iso-IS1 InsB protein, transposase YP_006781480.1 5017943 D 1133852 CDS YP_006781481.1 407484331 13700103 complement(5018313..5018549) 1 NC_018658.1 hypothetical protein 5018549 13700103 O3K_24175 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781481.1 5018313 R 1133852 CDS YP_006781482.1 407484332 13700104 complement(5018551..5022735) 1 NC_018658.1 COG3209 Rhs family protein; rhsB element core protein RshB 5022735 13700104 O3K_24180 Escherichia coli O104:H4 str. 2011C-3493 rhsB element core protein RshB YP_006781482.1 5018551 R 1133852 CDS YP_006781483.1 407484333 13700105 complement(5022895..5023107) 1 NC_018658.1 COG0254 Ribosomal protein L31; 50S ribosomal protein L31 5023107 rpmE 13700105 rpmE Escherichia coli O104:H4 str. 2011C-3493 50S ribosomal protein L31 YP_006781483.1 5022895 R 1133852 CDS YP_006781484.1 407484334 13700106 5023310..5025508 1 NC_018658.1 COG1198 Primosomal protein N' (replication factor Y) - superfamily II helicase; primosome assembly protein PriA 5025508 13700106 O3K_24190 Escherichia coli O104:H4 str. 2011C-3493 primosome assembly protein PriA YP_006781484.1 5023310 D 1133852 CDS YP_006781485.1 407484335 13700107 5025664..5026689 1 NC_018658.1 COG1609 Transcriptional regulators; DNA-binding transcriptional regulator CytR 5026689 13700107 O3K_24195 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator CytR YP_006781485.1 5025664 D 1133852 CDS YP_006781486.1 407484336 13700108 5026781..5027740 1 NC_018658.1 COG3087 Cell division protein; cell division protein FtsN 5027740 13700108 O3K_24200 Escherichia coli O104:H4 str. 2011C-3493 cell division protein FtsN YP_006781486.1 5026781 D 1133852 CDS YP_006781487.1 407484337 13700109 5027833..5028363 1 NC_018658.1 COG5405 ATP-dependent protease HslVU (ClpYQ), peptidase subunit; ATP-dependent protease subunit HslV 5028363 13700109 O3K_24205 Escherichia coli O104:H4 str. 2011C-3493 ATP-dependent protease subunit HslV YP_006781487.1 5027833 D 1133852 CDS YP_006781488.1 407484338 13700110 5028373..5029704 1 NC_018658.1 COG1220 ATP-dependent protease HslVU (ClpYQ), ATPase subunit; ATP-dependent protease ATP-binding subunit HslU 5029704 hslU 13700110 hslU Escherichia coli O104:H4 str. 2011C-3493 ATP-dependent protease ATP-binding subunit HslU YP_006781488.1 5028373 D 1133852 CDS YP_006781489.1 407484339 13700111 5029771..5030697 1 NC_018658.1 COG1575 1,4-dihydroxy-2-naphthoate octaprenyltransferase; 1,4-dihydroxy-2-naphthoate octaprenyltransferase 5030697 13700111 O3K_24215 Escherichia coli O104:H4 str. 2011C-3493 1,4-dihydroxy-2-naphthoate octaprenyltransferase YP_006781489.1 5029771 D 1133852 CDS YP_006781490.1 407484340 13700112 5030790..5031275 1 NC_018658.1 COG0684 Demethylmenaquinone methyltransferase; ribonuclease activity regulator protein RraA 5031275 13700112 O3K_24220 Escherichia coli O104:H4 str. 2011C-3493 ribonuclease activity regulator protein RraA YP_006781490.1 5030790 D 1133852 CDS YP_006781491.1 407484341 13700113 complement(5031360..5031599) 1 NC_018658.1 COG3074 Uncharacterized protein conserved in bacteria; septal ring assembly protein ZapB 5031599 13700113 O3K_24225 Escherichia coli O104:H4 str. 2011C-3493 septal ring assembly protein ZapB YP_006781491.1 5031360 R 1133852 CDS YP_006781492.1 407484342 13700114 5032031..5032876 1 NC_018658.1 COG0580 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family); glycerol uptake facilitator protein 5032876 13700114 O3K_24230 Escherichia coli O104:H4 str. 2011C-3493 glycerol uptake facilitator protein YP_006781492.1 5032031 D 1133852 CDS YP_006781493.1 407484343 13700115 5032899..5034407 1 NC_018658.1 COG0554 Glycerol kinase; glycerol kinase 5034407 glpK 13700115 glpK Escherichia coli O104:H4 str. 2011C-3493 glycerol kinase YP_006781493.1 5032899 D 1133852 CDS YP_006781494.1 407484344 13700116 5034543..5035553 1 NC_018658.1 COG1494 Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins; fructose 1,6-bisphosphatase II 5035553 glpX 13700116 glpX Escherichia coli O104:H4 str. 2011C-3493 fructose 1,6-bisphosphatase II YP_006781494.1 5034543 D 1133852 CDS YP_006781495.1 407484345 13700117 5035650..5036396 1 NC_018658.1 COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1; ferredoxin-NADP reductase 5036396 13700117 O3K_24245 Escherichia coli O104:H4 str. 2011C-3493 ferredoxin-NADP reductase YP_006781495.1 5035650 D 1133852 CDS YP_006781496.1 407484346 13700118 complement(5036401..5036829) 1 NC_018658.1 COG0589 Universal stress protein UspA and related nucleotide-binding proteins; universal stress protein UspD 5036829 13700118 O3K_24250 Escherichia coli O104:H4 str. 2011C-3493 universal stress protein UspD YP_006781496.1 5036401 R 1133852 CDS YP_006781497.1 407484347 13700119 complement(5036856..5037155) 1 NC_018658.1 COG3691 Uncharacterized protein conserved in bacteria; hypothetical protein 5037155 13700119 O3K_24255 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781497.1 5036856 R 1133852 CDS YP_006781498.1 407484348 13700120 complement(5037367..5037807) 1 NC_018658.1 COG3152 Predicted membrane protein; inner membrane protein 5037807 13700120 O3K_24260 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006781498.1 5037367 R 1133852 CDS YP_006781499.1 407484349 13700121 5037908..5038507 1 NC_018658.1 hypothetical protein 5038507 13700121 O3K_24265 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781499.1 5037908 D 1133852 CDS YP_006781500.1 407484350 13700122 5038615..5039382 1 NC_018658.1 COG0149 Triosephosphate isomerase; triosephosphate isomerase 5039382 tpiA 13700122 tpiA Escherichia coli O104:H4 str. 2011C-3493 triosephosphate isomerase YP_006781500.1 5038615 D 1133852 CDS YP_006781501.1 407484351 13700123 complement(5039437..5040192) 1 NC_018658.1 COG2134 CDP-diacylglycerol pyrophosphatase; CDP-diacylglycerol pyrophosphatase 5040192 13700123 O3K_24275 Escherichia coli O104:H4 str. 2011C-3493 CDP-diacylglycerol pyrophosphatase YP_006781501.1 5039437 R 1133852 CDS YP_006781502.1 407484352 13700124 complement(5040299..5041288) 1 NC_018658.1 COG1613 ABC-type sulfate transport system, periplasmic component; sulfate transporter subunit 5041288 13700124 O3K_24280 Escherichia coli O104:H4 str. 2011C-3493 sulfate transporter subunit YP_006781502.1 5040299 R 1133852 CDS YP_006781503.1 407484353 13700125 complement(5041608..5042570) 1 NC_018658.1 COG0205 6-phosphofructokinase; 6-phosphofructokinase 5042570 13700125 O3K_24285 Escherichia coli O104:H4 str. 2011C-3493 6-phosphofructokinase YP_006781503.1 5041608 R 1133852 CDS YP_006781504.1 407484354 13700126 complement(5042751..5043653) 1 NC_018658.1 COG0053 Predicted Co/Zn/Cd cation transporters; ferrous iron efflux protein F 5043653 fieF 13700126 fieF Escherichia coli O104:H4 str. 2011C-3493 ferrous iron efflux protein F YP_006781504.1 5042751 R 1133852 CDS YP_006781505.1 407484355 13700127 complement(5043802..5044302) 1 NC_018658.1 COG3678 P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein; repressor CpxP 5044302 cpxP 13700127 cpxP Escherichia coli O104:H4 str. 2011C-3493 repressor CpxP YP_006781505.1 5043802 R 1133852 CDS YP_006781506.1 407484356 13700128 5044452..5045150 1 NC_018658.1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; DNA-binding transcriptional regulator CpxR 5045150 13700128 O3K_24300 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator CpxR YP_006781506.1 5044452 D 1133852 CDS YP_006781507.1 407484357 13700129 5045147..5046520 1 NC_018658.1 COG0642 Signal transduction histidine kinase; two-component sensor protein 5046520 cpxA 13700129 cpxA Escherichia coli O104:H4 str. 2011C-3493 two-component sensor protein YP_006781507.1 5045147 D 1133852 CDS YP_006781508.1 407484358 13700130 complement(5046626..5047300) 1 NC_018658.1 COG2258 Uncharacterized protein conserved in bacteria; 6-N-hydroxylaminopurine resistance protein 5047300 13700130 O3K_24310 Escherichia coli O104:H4 str. 2011C-3493 6-N-hydroxylaminopurine resistance protein YP_006781508.1 5046626 R 1133852 CDS YP_006781509.1 407484359 13700131 complement(5047449..5048432) 1 NC_018658.1 2-keto-3-deoxygluconate permease 5048432 13700131 O3K_24315 Escherichia coli O104:H4 str. 2011C-3493 2-keto-3-deoxygluconate permease YP_006781509.1 5047449 R 1133852 CDS YP_006781510.1 407484360 13700132 complement(5048692..5049312) 1 NC_018658.1 COG0605 Superoxide dismutase; superoxide dismutase 5049312 13700132 O3K_24320 Escherichia coli O104:H4 str. 2011C-3493 superoxide dismutase YP_006781510.1 5048692 R 1133852 CDS YP_006781511.1 407484361 13700133 5049597..5050631 1 NC_018658.1 rhamnose-proton symporter 5050631 13700133 O3K_24325 Escherichia coli O104:H4 str. 2011C-3493 rhamnose-proton symporter YP_006781511.1 5049597 D 1133852 CDS YP_006781512.1 407484362 13700134 complement(5050628..5051566) 1 NC_018658.1 COG2207 AraC-type DNA-binding domain-containing proteins; transcriptional activator RhaR 5051566 13700134 O3K_24330 Escherichia coli O104:H4 str. 2011C-3493 transcriptional activator RhaR YP_006781512.1 5050628 R 1133852 CDS YP_006781513.1 407484363 13700135 complement(5051550..5052386) 1 NC_018658.1 COG2207 AraC-type DNA-binding domain-containing proteins; transcriptional activator RhaS 5052386 13700135 O3K_24335 Escherichia coli O104:H4 str. 2011C-3493 transcriptional activator RhaS YP_006781513.1 5051550 R 1133852 CDS YP_006781514.1 407484364 13700136 complement(5052446..5052595) 1 NC_018658.1 hypothetical protein 5052595 13700136 O3K_24340 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781514.1 5052446 R 1133852 CDS YP_006781515.1 407484365 13700137 5052674..5054143 1 NC_018658.1 COG1070 Sugar (pentulose and hexulose) kinases; rhamnulokinase 5054143 rhaB 13700137 rhaB Escherichia coli O104:H4 str. 2011C-3493 rhamnulokinase YP_006781515.1 5052674 D 1133852 CDS YP_006781516.1 407484366 13700138 5054140..5055399 1 NC_018658.1 COG4806 L-rhamnose isomerase; L-rhamnose isomerase 5055399 13700138 O3K_24350 Escherichia coli O104:H4 str. 2011C-3493 L-rhamnose isomerase YP_006781516.1 5054140 D 1133852 CDS YP_006781517.1 407484367 13700139 5055641..5056465 1 NC_018658.1 COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases; rhamnulose-1-phosphate aldolase 5056465 13700139 O3K_24355 Escherichia coli O104:H4 str. 2011C-3493 rhamnulose-1-phosphate aldolase YP_006781517.1 5055641 D 1133852 CDS YP_006781518.1 407484368 13700140 5056475..5056789 1 NC_018658.1 COG3254 Uncharacterized conserved protein; L-rhamnose mutarotase 5056789 13700140 O3K_24360 Escherichia coli O104:H4 str. 2011C-3493 L-rhamnose mutarotase YP_006781518.1 5056475 D 1133852 CDS YP_006781519.1 407484369 13700141 5057102..5057548 1 NC_018658.1 COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type); putative fructose-like phosphotransferase system subunit EIIA 5057548 13700141 O3K_24365 Escherichia coli O104:H4 str. 2011C-3493 putative fructose-like phosphotransferase system subunit EIIA YP_006781519.1 5057102 D 1133852 CDS YP_006781520.1 407484370 13700142 5057559..5059010 1 NC_018658.1 COG1445 Phosphotransferase system fructose-specific component IIB; PTS system transporter subunits IIBC 5059010 13700142 O3K_24370 Escherichia coli O104:H4 str. 2011C-3493 PTS system transporter subunits IIBC YP_006781520.1 5057559 D 1133852 CDS YP_006781521.1 407484371 13700143 5059000..5060070 1 NC_018658.1 COG1363 Cellulase M and related proteins; peptidase 5060070 13700143 O3K_24375 Escherichia coli O104:H4 str. 2011C-3493 peptidase YP_006781521.1 5059000 D 1133852 CDS YP_006781522.1 407484372 13700144 5060070..5061818 1 NC_018658.1 COG3711 Transcriptional antiterminator; putative frv operon regulatory protein 5061818 13700144 O3K_24380 Escherichia coli O104:H4 str. 2011C-3493 putative frv operon regulatory protein YP_006781522.1 5060070 D 1133852 CDS YP_006781523.1 407484373 13700145 complement(5061868..5062908) 1 NC_018658.1 hypothetical protein 5062908 13700145 O3K_24385 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781523.1 5061868 R 1133852 CDS YP_006781524.1 407484374 13700146 complement(5063061..5063894) 1 NC_018658.1 COG1526 Uncharacterized protein required for formate dehydrogenase activity; formate dehydrogenase accessory protein 5063894 13700146 O3K_24390 Escherichia coli O104:H4 str. 2011C-3493 formate dehydrogenase accessory protein YP_006781524.1 5063061 R 1133852 CDS YP_006781525.1 407484375 13700147 5064088..5064675 1 NC_018658.1 COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; formate dehydrogenase-O, large subunit 5064675 13700147 O3K_24395 Escherichia coli O104:H4 str. 2011C-3493 formate dehydrogenase-O, large subunit YP_006781525.1 5064088 D 1133852 CDS YP_006781526.1 407484376 13700148 5064724..5067138 1 NC_018658.1 COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; formate dehydrogenase-O, major subunit 5067138 13700148 O3K_24400 Escherichia coli O104:H4 str. 2011C-3493 formate dehydrogenase-O, major subunit YP_006781526.1 5064724 D 1133852 CDS YP_006781527.1 407484377 13700149 5067151..5068053 1 NC_018658.1 COG0437 Fe-S-cluster-containing hydrogenase components 1; formate dehydrogenase-O, iron-sulfur subunit 5068053 13700149 O3K_24405 Escherichia coli O104:H4 str. 2011C-3493 formate dehydrogenase-O, iron-sulfur subunit YP_006781527.1 5067151 D 1133852 CDS YP_006781528.1 407484378 13700150 5068050..5068685 1 NC_018658.1 COG2864 Cytochrome b subunit of formate dehydrogenase; formate dehydrogenase-O subunit gamma 5068685 13700150 O3K_24410 Escherichia coli O104:H4 str. 2011C-3493 formate dehydrogenase-O subunit gamma YP_006781528.1 5068050 D 1133852 CDS YP_006781529.1 407484379 13700151 5068682..5069611 1 NC_018658.1 COG3058 Uncharacterized protein involved in formate dehydrogenase formation; formate dehydrogenase accessory protein FdhE 5069611 13700151 O3K_24415 Escherichia coli O104:H4 str. 2011C-3493 formate dehydrogenase accessory protein FdhE YP_006781529.1 5068682 D 1133852 CDS YP_006781530.1 407484380 13700152 5069791..5069925 1 NC_018658.1 hypothetical protein 5069925 13700152 O3K_24420 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781530.1 5069791 D 1133852 CDS YP_006781531.1 407484381 13700153 complement(5069941..5070183) 1 NC_018658.1 COG1219 ATP-dependent protease Clp, ATPase subunit; hypothetical protein 5070183 13700153 O3K_24425 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781531.1 5069941 R 1133852 CDS YP_006781532.1 407484382 13700154 complement(5070403..5070621) 1 NC_018658.1 COG3905 Predicted transcriptional regulator; transcriptional regulator 5070621 13700154 O3K_24430 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator YP_006781532.1 5070403 R 1133852 CDS YP_006781533.1 407484383 13700155 complement(5071207..5071497) 1 NC_018658.1 COG2944 Predicted transcriptional regulator; hypothetical protein 5071497 13700155 O3K_24435 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781533.1 5071207 R 1133852 CDS YP_006781534.1 407484384 13700156 complement(5071498..5071809) 1 NC_018658.1 hypothetical protein 5071809 13700156 O3K_24440 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781534.1 5071498 R 1133852 CDS YP_006781535.1 407484385 13700157 5072038..5072946 1 NC_018658.1 COG0657 Esterase/lipase; putative lipase 5072946 13700157 O3K_24445 Escherichia coli O104:H4 str. 2011C-3493 putative lipase YP_006781535.1 5072038 D 1133852 CDS YP_006781536.1 407484386 13700158 complement(5073010..5073999) 1 NC_018658.1 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; acetyltransferase 5073999 13700158 O3K_24450 Escherichia coli O104:H4 str. 2011C-3493 acetyltransferase YP_006781536.1 5073010 R 1133852 CDS YP_006781537.1 407484387 13700159 complement(5073996..5074433) 1 NC_018658.1 COG1490 D-Tyr-tRNAtyr deacylase; D-tyrosyl-tRNA(Tyr) deacylase 5074433 13700159 O3K_24455 Escherichia coli O104:H4 str. 2011C-3493 D-tyrosyl-tRNA(Tyr) deacylase YP_006781537.1 5073996 R 1133852 CDS YP_006781538.1 407484388 13700160 complement(5074430..5075302) 1 NC_018658.1 COG1295 Predicted membrane protein; hypothetical protein 5075302 13700160 O3K_24460 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781538.1 5074430 R 1133852 CDS YP_006781539.1 407484389 13700161 complement(5075296..5075895) 1 NC_018658.1 COG1011 Predicted hydrolase (HAD superfamily); alpha-D-glucose-1-phosphatase 5075895 13700161 O3K_24465 Escherichia coli O104:H4 str. 2011C-3493 alpha-D-glucose-1-phosphatase YP_006781539.1 5075296 R 1133852 CDS YP_006781540.1 407484390 13700162 complement(5076036..5076923) 1 NC_018658.1 COG2017 Galactose mutarotase and related enzymes; galactose mutarotase 5076923 13700162 O3K_24470 Escherichia coli O104:H4 str. 2011C-3493 galactose mutarotase YP_006781540.1 5076036 R 1133852 CDS YP_006781541.1 407484391 13700163 complement(5076913..5078262) 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; transporter 5078262 13700163 O3K_24475 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006781541.1 5076913 R 1133852 CDS YP_006781542.1 407484392 13700164 complement(5078361..5079794) 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; transporter 5079794 13700164 O3K_24480 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006781542.1 5078361 R 1133852 CDS YP_006781543.1 407484393 13700165 complement(5079864..5080874) 1 NC_018658.1 COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases; dehydrogenase, GroES-like protein 5080874 13700165 O3K_24485 Escherichia coli O104:H4 str. 2011C-3493 dehydrogenase, GroES-like protein YP_006781543.1 5079864 R 1133852 CDS YP_006781544.1 407484394 13700166 complement(5080907..5081794) 1 NC_018658.1 COG3684 Tagatose-1,6-bisphosphate aldolase; aldolase yihT 5081794 13700166 O3K_24490 Escherichia coli O104:H4 str. 2011C-3493 aldolase yihT YP_006781544.1 5080907 R 1133852 CDS YP_006781545.1 407484395 13700167 complement(5081819..5082697) 1 NC_018658.1 COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases; NADH-dependent gamma-hydroxybutyrate dehydrogenase 5082697 13700167 O3K_24495 Escherichia coli O104:H4 str. 2011C-3493 NADH-dependent gamma-hydroxybutyrate dehydrogenase YP_006781545.1 5081819 R 1133852 CDS YP_006781546.1 407484396 13700168 5082870..5083766 1 NC_018658.1 COG0524 Sugar kinases, ribokinase family; sugar kinase 5083766 13700168 O3K_24500 Escherichia coli O104:H4 str. 2011C-3493 sugar kinase YP_006781546.1 5082870 D 1133852 CDS YP_006781547.1 407484397 13700169 5083806..5084594 1 NC_018658.1 COG1349 Transcriptional regulators of sugar metabolism; DEOR-type transcriptional regulator 5084594 13700169 O3K_24505 Escherichia coli O104:H4 str. 2011C-3493 DEOR-type transcriptional regulator YP_006781547.1 5083806 D 1133852 CDS YP_006781548.1 407484398 13700170 complement(5084705..5085970) 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; transporter 5085970 13700170 O3K_24510 Escherichia coli O104:H4 str. 2011C-3493 transporter YP_006781548.1 5084705 R 1133852 CDS YP_006781549.1 407484399 13700171 complement(5086072..5087052) 1 NC_018658.1 COG1082 Sugar phosphate isomerases/epimerases; sugar phosphate isomerase 5087052 13700171 O3K_24515 Escherichia coli O104:H4 str. 2011C-3493 sugar phosphate isomerase YP_006781549.1 5086072 R 1133852 CDS YP_006781550.1 407484400 13700172 complement(5087060..5087770) 1 NC_018658.1 COG2188 Transcriptional regulators; putative DNA-binding transcriptional regulator 5087770 13700172 O3K_24520 Escherichia coli O104:H4 str. 2011C-3493 putative DNA-binding transcriptional regulator YP_006781550.1 5087060 R 1133852 CDS YP_006781551.1 407484401 13700173 complement(5087987..5089810) 1 NC_018658.1 COG1217 Predicted membrane GTPase involved in stress response; GTP-binding protein 5089810 13700173 O3K_24525 Escherichia coli O104:H4 str. 2011C-3493 GTP-binding protein YP_006781551.1 5087987 R 1133852 CDS YP_006781552.1 407484402 13700174 5090183..5091592 1 NC_018658.1 COG0174 Glutamine synthetase; glutamine synthetase 5091592 glnA 13700174 glnA Escherichia coli O104:H4 str. 2011C-3493 glutamine synthetase YP_006781552.1 5090183 D 1133852 CDS YP_006781553.1 407484403 13700175 5091878..5092927 1 NC_018658.1 COG3852 Signal transduction histidine kinase, nitrogen specific; nitrogen regulation protein NR(II) 5092927 glnL 13700175 glnL Escherichia coli O104:H4 str. 2011C-3493 nitrogen regulation protein NR(II) YP_006781553.1 5091878 D 1133852 CDS YP_006781554.1 407484404 13700176 5092939..5094348 1 NC_018658.1 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains; nitrogen regulation protein NR(I) 5094348 glnG 13700176 glnG Escherichia coli O104:H4 str. 2011C-3493 nitrogen regulation protein NR(I) YP_006781554.1 5092939 D 1133852 CDS YP_006781555.1 407484405 13700177 5094460..5094570 1 NC_018658.1 hypothetical protein 5094570 13700177 O3K_24545 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781555.1 5094460 D 1133852 CDS YP_006781556.1 407484406 13700178 complement(5094760..5096133) 1 NC_018658.1 COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases; coproporphyrinogen III oxidase 5096133 13700178 O3K_24550 Escherichia coli O104:H4 str. 2011C-3493 coproporphyrinogen III oxidase YP_006781556.1 5094760 R 1133852 CDS YP_006781557.1 407484407 13700179 complement(5096322..5096831) 1 NC_018658.1 COG3078 Uncharacterized protein conserved in bacteria; GTPase activator 5096831 13700179 O3K_24555 Escherichia coli O104:H4 str. 2011C-3493 GTPase activator YP_006781557.1 5096322 R 1133852 CDS YP_006781558.1 407484408 13700180 complement(5097039..5097116) 1 NC_018658.1 hypothetical protein 5097116 13700180 O3K_24560 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781558.1 5097039 R 1133852 CDS YP_006781559.1 407484409 13700181 5097413..5098045 1 NC_018658.1 COG0218 Predicted GTPase; GTP-binding protein YsxC 5098045 engB 13700181 engB Escherichia coli O104:H4 str. 2011C-3493 GTP-binding protein YsxC YP_006781559.1 5097413 D 1133852 CDS YP_006781560.1 407484410 13700182 complement(5098427..5101213) 1 NC_018658.1 COG0258 5'-3' exonuclease (including N-terminal domain of PolI); DNA polymerase I 5101213 13700182 O3K_24570 Escherichia coli O104:H4 str. 2011C-3493 DNA polymerase I YP_006781560.1 5098427 R 1133852 CDS YP_006781561.1 407484411 13700183 5101215..5101457 1 NC_018658.1 hypothetical protein 5101457 13700183 O3K_24575 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781561.1 5101215 D 1133852 CDS YP_006781562.1 407484412 13700184 5101577..5102509 1 NC_018658.1 COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase; putative acyltransferase 5102509 13700184 O3K_24580 Escherichia coli O104:H4 str. 2011C-3493 putative acyltransferase YP_006781562.1 5101577 D 1133852 CDS YP_006781563.1 407484413 13700185 complement(5102550..5103980) 1 NC_018658.1 COG5339 Uncharacterized protein conserved in bacteria; hypothetical protein 5103980 13700185 O3K_24585 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781563.1 5102550 R 1133852 CDS YP_006781564.1 407484414 13700186 complement(5104135..5104761) 1 NC_018658.1 COG0526 Thiol-disulfide isomerase and thioredoxins; protein disulfide isomerase I 5104761 13700186 O3K_24590 Escherichia coli O104:H4 str. 2011C-3493 protein disulfide isomerase I YP_006781564.1 5104135 R 1133852 CDS YP_006781565.1 407484415 13700187 complement(5104778..5105764) 1 NC_018658.1 COG2334 Putative homoserine kinase type II (protein kinase fold); serine/threonine protein kinase 5105764 13700187 O3K_24595 Escherichia coli O104:H4 str. 2011C-3493 serine/threonine protein kinase YP_006781565.1 5104778 R 1133852 CDS YP_006781566.1 407484416 13700188 complement(5105841..5106110) 1 NC_018658.1 COG3084 Uncharacterized protein conserved in bacteria; hypothetical protein 5106110 13700188 O3K_24600 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781566.1 5105841 R 1133852 CDS YP_006781567.1 407484417 13700189 5106180..5106764 1 NC_018658.1 COG0746 Molybdopterin-guanine dinucleotide biosynthesis protein A; molybdopterin-guanine dinucleotide biosynthesis protein MobA 5106764 mobA 13700189 mobA Escherichia coli O104:H4 str. 2011C-3493 molybdopterin-guanine dinucleotide biosynthesis protein MobA YP_006781567.1 5106180 D 1133852 CDS YP_006781568.1 407484418 13700190 5106746..5107273 1 NC_018658.1 COG1763 Molybdopterin-guanine dinucleotide biosynthesis protein; molybdopterin-guanine dinucleotide biosynthesis protein MobB 5107273 13700190 O3K_24610 Escherichia coli O104:H4 str. 2011C-3493 molybdopterin-guanine dinucleotide biosynthesis protein MobB YP_006781568.1 5106746 D 1133852 CDS YP_006781569.1 407484419 13700196 complement(5112859..5113404) 1 NC_018658.1 COG4635 Flavodoxin; protoporphyrinogen oxidase 5113404 hemG 13700196 hemG Escherichia coli O104:H4 str. 2011C-3493 protoporphyrinogen oxidase YP_006781569.1 5112859 R 1133852 CDS YP_006781570.1 407484420 13700197 complement(5113416..5114867) 1 NC_018658.1 COG0168 Trk-type K+ transport systems, membrane components; potassium transporter 5114867 13700197 O3K_24620 Escherichia coli O104:H4 str. 2011C-3493 potassium transporter YP_006781570.1 5113416 R 1133852 CDS YP_006781571.1 407484421 13700198 complement(5114906..5115520) 1 NC_018658.1 COG1739 Uncharacterized conserved protein; hypothetical protein 5115520 13700198 O3K_24625 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781571.1 5114906 R 1133852 CDS YP_006781572.1 407484422 13700199 complement(5115520..5116851) 1 NC_018658.1 COG0006 Xaa-Pro aminopeptidase; proline dipeptidase 5116851 13700199 O3K_24630 Escherichia coli O104:H4 str. 2011C-3493 proline dipeptidase YP_006781572.1 5115520 R 1133852 CDS YP_006781573.1 407484423 13700200 5117041..5119230 1 NC_018658.1 COG1024 Enoyl-CoA hydratase/carnithine racemase; multifunctional fatty acid oxidation complex subunit alpha 5119230 fadB 13700200 fadB Escherichia coli O104:H4 str. 2011C-3493 multifunctional fatty acid oxidation complex subunit alpha YP_006781573.1 5117041 D 1133852 CDS YP_006781574.1 407484424 13700201 5119240..5120403 1 NC_018658.1 COG0183 Acetyl-CoA acetyltransferase; 3-ketoacyl-CoA thiolase 5120403 fadA 13700201 fadA Escherichia coli O104:H4 str. 2011C-3493 3-ketoacyl-CoA thiolase YP_006781574.1 5119240 D 1133852 CDS YP_006781575.1 407484425 13700202 complement(5120595..5121296) 1 NC_018658.1 COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases; FMN reductase 5121296 fre 13700202 fre Escherichia coli O104:H4 str. 2011C-3493 FMN reductase YP_006781575.1 5120595 R 1133852 CDS YP_006781576.1 407484426 13700203 complement(5121342..5122835) 1 NC_018658.1 COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase 5122835 13700203 O3K_24650 Escherichia coli O104:H4 str. 2011C-3493 3-octaprenyl-4-hydroxybenzoate carboxy-lyase YP_006781576.1 5121342 R 1133852 CDS YP_006781577.1 407484427 13700204 5123002..5123490 1 NC_018658.1 COG0250 Transcription antiterminator; transcriptional activator RfaH 5123490 rfaH 13700204 rfaH Escherichia coli O104:H4 str. 2011C-3493 transcriptional activator RfaH YP_006781577.1 5123002 D 1133852 CDS YP_006781578.1 407484428 13700205 complement(5123487..5124269) 1 NC_018658.1 COG0084 Mg-dependent DNase; DNase TatD 5124269 13700205 O3K_24660 Escherichia coli O104:H4 str. 2011C-3493 DNase TatD YP_006781578.1 5123487 R 1133852 CDS YP_006781579.1 407484429 13700206 complement(5124311..5125087) 1 NC_018658.1 COG0805 Sec-independent protein secretion pathway component TatC; twin-arginine protein translocation system subunit TatC 5125087 13700206 O3K_24665 Escherichia coli O104:H4 str. 2011C-3493 twin-arginine protein translocation system subunit TatC YP_006781579.1 5124311 R 1133852 CDS YP_006781580.1 407484430 13700207 complement(5125090..5125605) 1 NC_018658.1 COG1826 Sec-independent protein secretion pathway components; sec-independent translocase 5125605 13700207 O3K_24670 Escherichia coli O104:H4 str. 2011C-3493 sec-independent translocase YP_006781580.1 5125090 R 1133852 CDS YP_006781581.1 407484431 13700208 complement(5125609..5125878) 1 NC_018658.1 COG1826 Sec-independent protein secretion pathway components; twin arginine translocase protein A 5125878 tatA 13700208 tatA Escherichia coli O104:H4 str. 2011C-3493 twin arginine translocase protein A YP_006781581.1 5125609 R 1133852 CDS YP_006781582.1 407484432 13700209 complement(5125957..5127597) 1 NC_018658.1 COG0661 Predicted unusual protein kinase; putative ubiquinone biosynthesis protein UbiB 5127597 ubiB 13700209 ubiB Escherichia coli O104:H4 str. 2011C-3493 putative ubiquinone biosynthesis protein UbiB YP_006781582.1 5125957 R 1133852 CDS YP_006781583.1 407484433 13700210 complement(5127594..5128199) 1 NC_018658.1 COG3165 Uncharacterized protein conserved in bacteria; hypothetical protein 5128199 13700210 O3K_24685 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781583.1 5127594 R 1133852 CDS YP_006781584.1 407484434 13700211 complement(5128213..5128968) 1 NC_018658.1 COG2226 Methylase involved in ubiquinone/menaquinone biosynthesis; ubiquinone/menaquinone biosynthesis methyltransferase 5128968 ubiE 13700211 ubiE Escherichia coli O104:H4 str. 2011C-3493 ubiquinone/menaquinone biosynthesis methyltransferase YP_006781584.1 5128213 R 1133852 CDS YP_006781585.1 407484435 13700212 complement(5129063..5130490) 1 NC_018658.1 COG1322 Uncharacterized protein conserved in bacteria; DNA recombination protein RmuC 5130490 13700212 O3K_24695 Escherichia coli O104:H4 str. 2011C-3493 DNA recombination protein RmuC YP_006781585.1 5129063 R 1133852 CDS YP_006781586.1 407484436 13700213 complement(5130631..5131392) 1 NC_018658.1 COG2820 Uridine phosphorylase; uridine phosphorylase 5131392 13700213 O3K_24700 Escherichia coli O104:H4 str. 2011C-3493 uridine phosphorylase YP_006781586.1 5130631 R 1133852 CDS YP_006781587.1 407484437 13700214 5131654..5132469 1 NC_018658.1 COG0412 Dienelactone hydrolase and related enzymes; hydrolase 5132469 13700214 O3K_24705 Escherichia coli O104:H4 str. 2011C-3493 hydrolase YP_006781587.1 5131654 D 1133852 CDS YP_006781588.1 407484438 13700215 complement(5132508..5134769) 1 NC_018658.1 COG0620 Methionine synthase II (cobalamin-independent); 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase 5134769 13700215 O3K_24710 Escherichia coli O104:H4 str. 2011C-3493 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase YP_006781588.1 5132508 R 1133852 CDS YP_006781589.1 407484439 13700216 5134887..5135840 1 NC_018658.1 COG0583 Transcriptional regulator; DNA-binding transcriptional regulator MetR 5135840 13700216 O3K_24715 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator MetR YP_006781589.1 5134887 D 1133852 CDS YP_006781590.1 407484440 13700217 complement(5135728..5136627) 1 NC_018658.1 COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; hypothetical protein 5136627 13700217 O3K_24720 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781590.1 5135728 R 1133852 CDS YP_006781591.1 407484441 13700218 complement(5136703..5137503) 1 NC_018658.1 COG0561 Predicted hydrolases of the HAD superfamily; hydrolase 5137503 13700218 O3K_24725 Escherichia coli O104:H4 str. 2011C-3493 hydrolase YP_006781591.1 5136703 R 1133852 CDS YP_006781592.1 407484442 13700219 complement(5137511..5138533) 1 NC_018658.1 COG2267 Lysophospholipase; lysophospholipase L2 5138533 13700219 O3K_24730 Escherichia coli O104:H4 str. 2011C-3493 lysophospholipase L2 YP_006781592.1 5137511 R 1133852 CDS YP_006781593.1 407484443 13700220 5138644..5139264 1 NC_018658.1 COG1280 Putative threonine efflux protein; homoserine/homoserine lactone efflux protein 5139264 rhtB 13700220 rhtB Escherichia coli O104:H4 str. 2011C-3493 homoserine/homoserine lactone efflux protein YP_006781593.1 5138644 D 1133852 CDS YP_006781594.1 407484444 13700221 complement(5139326..5139946) 1 NC_018658.1 COG1280 Putative threonine efflux protein; threonine efflux system 5139946 13700221 O3K_24740 Escherichia coli O104:H4 str. 2011C-3493 threonine efflux system YP_006781594.1 5139326 R 1133852 CDS YP_006781595.1 407484445 13700222 complement(5140010..5141839) 1 NC_018658.1 COG0514 Superfamily II DNA helicase; ATP-dependent DNA helicase RecQ 5141839 13700222 O3K_24745 Escherichia coli O104:H4 str. 2011C-3493 ATP-dependent DNA helicase RecQ YP_006781595.1 5140010 R 1133852 CDS YP_006781596.1 407484446 13700223 complement(5141972..5142841) 1 NC_018658.1 COG2829 Outer membrane phospholipase A; phospholipase A 5142841 13700223 O3K_24750 Escherichia coli O104:H4 str. 2011C-3493 phospholipase A YP_006781596.1 5141972 R 1133852 CDS YP_006781597.1 407484447 13700224 5143006..5143473 1 NC_018658.1 COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism; hypothetical protein 5143473 13700224 O3K_24755 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781597.1 5143006 D 1133852 CDS YP_006781598.1 407484448 13700225 5143525..5144412 1 NC_018658.1 COG2962 Predicted permeases; putative chloramphenical resistance permease RarD 5144412 13700225 O3K_24760 Escherichia coli O104:H4 str. 2011C-3493 putative chloramphenical resistance permease RarD YP_006781598.1 5143525 D 1133852 CDS YP_006781599.1 407484449 13700226 complement(5144459..5144758) 1 NC_018658.1 hypothetical protein 5144758 13700226 O3K_24765 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781599.1 5144459 R 1133852 CDS YP_006781600.1 407484450 13700227 complement(5145404..5145601) 1 NC_018658.1 COG0598 Mg2+ and Co2+ transporters; hypothetical protein 5145601 13700227 O3K_24770 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781600.1 5145404 R 1133852 CDS YP_006781601.1 407484451 13700228 5145737..5146585 1 NC_018658.1 hypothetical protein 5146585 13700228 O3K_24775 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781601.1 5145737 D 1133852 CDS YP_006781602.1 407484452 13700229 5146582..5147073 1 NC_018658.1 hypothetical protein 5147073 13700229 O3K_24780 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781602.1 5146582 D 1133852 CDS YP_006781603.1 407484453 13700230 complement(5147115..5148065) 1 NC_018658.1 COG0598 Mg2+ and Co2+ transporters; magnesium/nickel/cobalt transporter CorA 5148065 13700230 O3K_24785 Escherichia coli O104:H4 str. 2011C-3493 magnesium/nickel/cobalt transporter CorA YP_006781603.1 5147115 R 1133852 CDS YP_006781604.1 407484454 13700231 complement(5148309..5148443) 1 NC_018658.1 hypothetical protein 5148443 13700231 O3K_24790 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781604.1 5148309 R 1133852 CDS YP_006781605.1 407484455 13700232 5148435..5149199 1 NC_018658.1 COG3698 Predicted periplasmic protein; hypothetical protein 5149199 13700232 O3K_24795 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781605.1 5148435 D 1133852 CDS YP_006781606.1 407484456 13700233 complement(5149346..5151508) 1 NC_018658.1 COG0210 Superfamily I DNA and RNA helicases; DNA-dependent helicase II 5151508 uvrD 13700233 uvrD Escherichia coli O104:H4 str. 2011C-3493 DNA-dependent helicase II YP_006781606.1 5149346 R 1133852 CDS YP_006781607.1 407484457 13700234 complement(5151592..5152308) 1 NC_018658.1 COG1011 Predicted hydrolase (HAD superfamily); flavin mononucleotide phosphatase 5152308 13700234 O3K_24805 Escherichia coli O104:H4 str. 2011C-3493 flavin mononucleotide phosphatase YP_006781607.1 5151592 R 1133852 CDS YP_006781608.1 407484458 13700235 complement(5152308..5153204) 1 NC_018658.1 COG4973 Site-specific recombinase XerC; site-specific tyrosine recombinase XerC 5153204 xerC 13700235 xerC Escherichia coli O104:H4 str. 2011C-3493 site-specific tyrosine recombinase XerC YP_006781608.1 5152308 R 1133852 CDS YP_006781609.1 407484459 13700236 complement(5153201..5153908) 1 NC_018658.1 COG3159 Uncharacterized protein conserved in bacteria; hypothetical protein 5153908 13700236 O3K_24815 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781609.1 5153201 R 1133852 CDS YP_006781610.1 407484460 13700237 complement(5153905..5154729) 1 NC_018658.1 COG0253 Diaminopimelate epimerase; diaminopimelate epimerase 5154729 dapF 13700237 dapF Escherichia coli O104:H4 str. 2011C-3493 diaminopimelate epimerase YP_006781610.1 5153905 R 1133852 CDS YP_006781611.1 407484461 13700238 complement(5154766..5154969) 1 NC_018658.1 COG5567 Predicted small periplasmic lipoprotein; lipoprotein 5154969 13700238 O3K_24825 Escherichia coli O104:H4 str. 2011C-3493 lipoprotein YP_006781611.1 5154766 R 1133852 CDS YP_006781612.1 407484462 13700239 5155319..5155873 1 NC_018658.1 hypothetical protein 5155873 13700239 O3K_24830 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781612.1 5155319 D 1133852 CDS YP_006781613.1 407484463 13700240 5156241..5157719 1 NC_018658.1 hypothetical protein 5157719 13700240 O3K_24835 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781613.1 5156241 D 1133852 CDS YP_006781614.1 407484464 13700241 5157716..5159041 1 NC_018658.1 hypothetical protein 5159041 13700241 O3K_24840 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781614.1 5157716 D 1133852 CDS YP_006781615.1 407484465 13700242 5159089..5159409 1 NC_018658.1 COG1965 Protein implicated in iron transport, frataxin homolog; frataxin-like protein 5159409 cyaY 13700242 cyaY Escherichia coli O104:H4 str. 2011C-3493 frataxin-like protein YP_006781615.1 5159089 D 1133852 CDS YP_006781616.1 407484466 13700243 complement(5159449..5161995) 1 NC_018658.1 COG3072 Adenylate cyclase; adenylate cyclase 5161995 cyaA 13700243 cyaA Escherichia coli O104:H4 str. 2011C-3493 adenylate cyclase YP_006781616.1 5159449 R 1133852 CDS YP_006781617.1 407484467 13700244 5162382..5163323 1 NC_018658.1 COG0181 Porphobilinogen deaminase; porphobilinogen deaminase 5163323 hemC 13700244 hemC Escherichia coli O104:H4 str. 2011C-3493 porphobilinogen deaminase YP_006781617.1 5162382 D 1133852 CDS YP_006781618.1 407484468 13700245 5163320..5164060 1 NC_018658.1 COG1587 Uroporphyrinogen-III synthase; uroporphyrinogen-III synthase 5164060 hemD 13700245 hemD Escherichia coli O104:H4 str. 2011C-3493 uroporphyrinogen-III synthase YP_006781618.1 5163320 D 1133852 CDS YP_006781619.1 407484469 13700246 5164082..5165317 1 NC_018658.1 COG2959 Uncharacterized enzyme of heme biosynthesis; putative uroporphyrinogen III C-methyltransferase 5165317 13700246 O3K_24865 Escherichia coli O104:H4 str. 2011C-3493 putative uroporphyrinogen III C-methyltransferase YP_006781619.1 5164082 D 1133852 CDS YP_006781620.1 407484470 13700247 5165320..5166516 1 NC_018658.1 COG3071 Uncharacterized enzyme of heme biosynthesis; putative protoheme IX biogenesis protein 5166516 13700247 O3K_24870 Escherichia coli O104:H4 str. 2011C-3493 putative protoheme IX biogenesis protein YP_006781620.1 5165320 D 1133852 CDS YP_006781621.1 407484471 13700248 5167195..5167356 1 NC_018658.1 hypothetical protein 5167356 13700248 O3K_24875 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781621.1 5167195 D 1133852 CDS YP_006781622.1 407484472 13700249 complement(5167440..5168675) 1 NC_018658.1 COG0641 Arylsulfatase regulator (Fe-S oxidoreductase); regulator of arylsulfatase activity 5168675 13700249 O3K_24880 Escherichia coli O104:H4 str. 2011C-3493 regulator of arylsulfatase activity YP_006781622.1 5167440 R 1133852 CDS YP_006781623.1 407484473 13700254 complement(5169361..5170746) 1 NC_018658.1 COG1113 Gamma-aminobutyrate permease and related permeases; putative transport protein YifK 5170746 13700254 O3K_24885 Escherichia coli O104:H4 str. 2011C-3493 putative transport protein YifK YP_006781623.1 5169361 R 1133852 CDS YP_006781624.1 407484474 13700255 complement(5170937..5171677) 1 NC_018658.1 COG1922 Teichoic acid biosynthesis proteins; putative UDP-N-acetyl-D-mannosaminuronic acid transferase 5171677 13700255 O3K_24890 Escherichia coli O104:H4 str. 2011C-3493 putative UDP-N-acetyl-D-mannosaminuronic acid transferase YP_006781624.1 5170937 R 1133852 CDS YP_006781625.1 407484475 13700256 complement(5171680..5173032) 1 NC_018658.1 putative common antigen polymerase 5173032 13700256 O3K_24895 Escherichia coli O104:H4 str. 2011C-3493 putative common antigen polymerase YP_006781625.1 5171680 R 1133852 CDS YP_006781626.1 407484476 13700257 complement(5173029..5174108) 1 NC_018658.1 4-alpha-L-fucosyltransferase 5174108 13700257 O3K_24900 Escherichia coli O104:H4 str. 2011C-3493 4-alpha-L-fucosyltransferase YP_006781626.1 5173029 R 1133852 CDS YP_006781627.1 407484477 13700258 complement(5174105..5175355) 1 NC_018658.1 COG2244 Membrane protein involved in the export of O-antigen and teichoic acid; O-antigen translocase 5175355 13700258 O3K_24905 Escherichia coli O104:H4 str. 2011C-3493 O-antigen translocase YP_006781627.1 5174105 R 1133852 CDS YP_006781628.1 407484478 13700259 complement(5175357..5176487) 1 NC_018658.1 COG0399 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis; TDP-4-oxo-6-deoxy-D-glucose transaminase 5176487 13700259 O3K_24910 Escherichia coli O104:H4 str. 2011C-3493 TDP-4-oxo-6-deoxy-D-glucose transaminase YP_006781628.1 5175357 R 1133852 CDS YP_006781629.1 407484479 13700260 complement(5176492..5177166) 1 NC_018658.1 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; TDP-fucosamine acetyltransferase 5177166 13700260 O3K_24915 Escherichia coli O104:H4 str. 2011C-3493 TDP-fucosamine acetyltransferase YP_006781629.1 5176492 R 1133852 CDS YP_006781630.1 407484480 13700261 complement(5177144..5178025) 1 NC_018658.1 COG1209 dTDP-glucose pyrophosphorylase; glucose-1-phosphate thymidylyltransferase 5178025 13700261 O3K_24920 Escherichia coli O104:H4 str. 2011C-3493 glucose-1-phosphate thymidylyltransferase YP_006781630.1 5177144 R 1133852 CDS YP_006781631.1 407484481 13700262 complement(5178044..5179111) 1 NC_018658.1 COG1088 dTDP-D-glucose 4,6-dehydratase; dTDP-glucose 4,6-dehydratase 5179111 13700262 O3K_24925 Escherichia coli O104:H4 str. 2011C-3493 dTDP-glucose 4,6-dehydratase YP_006781631.1 5178044 R 1133852 CDS YP_006781632.1 407484482 13700263 complement(5179111..5180373) 1 NC_018658.1 COG0677 UDP-N-acetyl-D-mannosaminuronate dehydrogenase; UDP-N-acetyl-D-mannosamine dehydrogenase 5180373 wecC 13700263 wecC Escherichia coli O104:H4 str. 2011C-3493 UDP-N-acetyl-D-mannosamine dehydrogenase YP_006781632.1 5179111 R 1133852 CDS YP_006781633.1 407484483 13700264 complement(5180370..5181500) 1 NC_018658.1 COG0381 UDP-N-acetylglucosamine 2-epimerase; UDP-N-acetylglucosamine 2-epimerase 5181500 13700264 O3K_24935 Escherichia coli O104:H4 str. 2011C-3493 UDP-N-acetylglucosamine 2-epimerase YP_006781633.1 5180370 R 1133852 CDS YP_006781634.1 407484484 13700265 complement(5181556..5182602) 1 NC_018658.1 COG3765 Chain length determinant protein; lipopolysaccharide biosynthesis protein WzzE 5182602 13700265 O3K_24940 Escherichia coli O104:H4 str. 2011C-3493 lipopolysaccharide biosynthesis protein WzzE YP_006781634.1 5181556 R 1133852 CDS YP_006781635.1 407484485 13700266 complement(5182614..5183717) 1 NC_018658.1 COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase; undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase 5183717 13700266 O3K_24945 Escherichia coli O104:H4 str. 2011C-3493 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase YP_006781635.1 5182614 R 1133852 CDS YP_006781636.1 407484486 13700267 complement(5183729..5183947) 1 NC_018658.1 hypothetical protein 5183947 13700267 O3K_24950 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781636.1 5183729 R 1133852 CDS YP_006781637.1 407484487 13700268 complement(5183957..5185216) 1 NC_018658.1 COG1158 Transcription termination factor; transcription termination factor Rho 5185216 rho 13700268 rho Escherichia coli O104:H4 str. 2011C-3493 transcription termination factor Rho YP_006781637.1 5183957 R 1133852 CDS YP_006781638.1 407484488 13700269 complement(5185301..5185402) 1 NC_018658.1 putative rho operon leader peptide 5185402 13700269 O3K_24960 Escherichia coli O104:H4 str. 2011C-3493 putative rho operon leader peptide YP_006781638.1 5185301 R 1133852 CDS YP_006781639.1 407484489 13700270 complement(5185543..5185872) 1 NC_018658.1 COG0526 Thiol-disulfide isomerase and thioredoxins; thioredoxin 5185872 trxA 13700270 trxA Escherichia coli O104:H4 str. 2011C-3493 thioredoxin YP_006781639.1 5185543 R 1133852 CDS YP_006781640.1 407484490 13700271 5186003..5187268 1 NC_018658.1 COG0513 Superfamily II DNA and RNA helicases; ATP-dependent RNA helicase RhlB 5187268 13700271 O3K_24970 Escherichia coli O104:H4 str. 2011C-3493 ATP-dependent RNA helicase RhlB YP_006781640.1 5186003 D 1133852 CDS YP_006781641.1 407484491 13700272 5187402..5188886 1 NC_018658.1 COG0248 Exopolyphosphatase; guanosine pentaphosphate phosphohydrolase 5188886 13700272 O3K_24975 Escherichia coli O104:H4 str. 2011C-3493 guanosine pentaphosphate phosphohydrolase YP_006781641.1 5187402 D 1133852 CDS YP_006781642.1 407484492 13700273 complement(5188933..5190954) 1 NC_018658.1 COG0210 Superfamily I DNA and RNA helicases; ATP-dependent DNA helicase Rep 5190954 13700273 O3K_24980 Escherichia coli O104:H4 str. 2011C-3493 ATP-dependent DNA helicase Rep YP_006781642.1 5188933 R 1133852 CDS YP_006781643.1 407484493 13700274 5191171..5191620 1 NC_018658.1 COG3692 Uncharacterized protein conserved in bacteria; hypothetical protein 5191620 13700274 O3K_24985 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781643.1 5191171 D 1133852 CDS YP_006781644.1 407484494 13700275 5191819..5192100 1 NC_018658.1 COG0760 Parvulin-like peptidyl-prolyl isomerase; peptidyl-prolyl cis-trans isomerase C 5192100 13700275 O3K_24990 Escherichia coli O104:H4 str. 2011C-3493 peptidyl-prolyl cis-trans isomerase C YP_006781644.1 5191819 D 1133852 CDS YP_006781645.1 407484495 13700276 complement(5192187..5193662) 1 NC_018658.1 COG0059 Ketol-acid reductoisomerase; ketol-acid reductoisomerase 5193662 13700276 O3K_24995 Escherichia coli O104:H4 str. 2011C-3493 ketol-acid reductoisomerase YP_006781645.1 5192187 R 1133852 CDS YP_006781646.1 407484496 13700277 5193812..5194705 1 NC_018658.1 COG0583 Transcriptional regulator; DNA-binding transcriptional regulator IlvY 5194705 13700277 O3K_25000 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator IlvY YP_006781646.1 5193812 D 1133852 CDS YP_006781647.1 407484497 13700278 complement(5194757..5196301) 1 NC_018658.1 COG1171 Threonine dehydratase; threonine dehydratase 5196301 13700278 O3K_25005 Escherichia coli O104:H4 str. 2011C-3493 threonine dehydratase YP_006781647.1 5194757 R 1133852 CDS YP_006781648.1 407484498 13700279 complement(5196304..5198154) 1 NC_018658.1 COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; dihydroxy-acid dehydratase 5198154 13700279 O3K_25010 Escherichia coli O104:H4 str. 2011C-3493 dihydroxy-acid dehydratase YP_006781648.1 5196304 R 1133852 CDS YP_006781649.1 407484499 13700280 complement(5198219..5199148) 1 NC_018658.1 COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; branched-chain amino acid aminotransferase 5199148 13700280 O3K_25015 Escherichia coli O104:H4 str. 2011C-3493 branched-chain amino acid aminotransferase YP_006781649.1 5198219 R 1133852 CDS YP_006781650.1 407484500 13700281 complement(5199168..5199431) 1 NC_018658.1 COG3978 Acetolactate synthase (isozyme II), small (regulatory) subunit; acetolactate synthase 2 regulatory subunit 5199431 ilvM 13700281 ilvM Escherichia coli O104:H4 str. 2011C-3493 acetolactate synthase 2 regulatory subunit YP_006781650.1 5199168 R 1133852 CDS YP_006781651.1 407484501 13700282 complement(5199428..5201074) 1 NC_018658.1 COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; acetolactate synthase 2 catalytic subunit 5201074 13700282 O3K_25025 Escherichia coli O104:H4 str. 2011C-3493 acetolactate synthase 2 catalytic subunit YP_006781651.1 5199428 R 1133852 CDS YP_006781652.1 407484502 13700283 5201665..5203185 1 NC_018658.1 COG0606 Predicted ATPase with chaperone activity; putative ATP-dependent protease 5203185 13700283 O3K_25030 Escherichia coli O104:H4 str. 2011C-3493 putative ATP-dependent protease YP_006781652.1 5201665 D 1133852 CDS YP_006781653.1 407484503 13700284 complement(5203210..5203548) 1 NC_018658.1 COG3085 Uncharacterized protein conserved in bacteria; hypothetical protein 5203548 13700284 O3K_25035 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781653.1 5203210 R 1133852 CDS YP_006781654.1 407484504 13700285 5203667..5204506 1 NC_018658.1 COG0583 Transcriptional regulator; transcriptional regulator HdfR 5204506 13700285 O3K_25040 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator HdfR YP_006781654.1 5203667 D 1133852 CDS YP_006781655.1 407484505 13700293 5210400..5211092 1 NC_018658.1 COG2186 Transcriptional regulators; transcriptional regulator 5211092 13700293 O3K_25045 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator YP_006781655.1 5210400 D 1133852 CDS YP_006781656.1 407484506 13700295 5211115..5212542 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; multidrug or homocysteine efflux system 5212542 13700295 O3K_25050 Escherichia coli O104:H4 str. 2011C-3493 multidrug or homocysteine efflux system YP_006781656.1 5211115 D 1133852 CDS YP_006781657.1 407484507 13700296 complement(5212508..5213500) 1 NC_018658.1 COG1609 Transcriptional regulators; transcriptional repressor RbsR 5213500 13700296 O3K_25055 Escherichia coli O104:H4 str. 2011C-3493 transcriptional repressor RbsR YP_006781657.1 5212508 R 1133852 CDS YP_006781658.1 407484508 13700868 complement(5213504..5214433) 1 NC_018658.1 COG0524 Sugar kinases, ribokinase family; ribokinase 5214433 13700868 O3K_25060 Escherichia coli O104:H4 str. 2011C-3493 ribokinase YP_006781658.1 5213504 R 1133852 CDS YP_006781659.1 407484509 13700869 complement(5214559..5215449) 1 NC_018658.1 COG1879 ABC-type sugar transport system, periplasmic component; D-ribose transporter subunit RbsB 5215449 13700869 O3K_25065 Escherichia coli O104:H4 str. 2011C-3493 D-ribose transporter subunit RbsB YP_006781659.1 5214559 R 1133852 CDS YP_006781660.1 407484510 13700870 complement(5215474..5216439) 1 NC_018658.1 COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components; ribose ABC transporter permease 5216439 rbsC 13700870 rbsC Escherichia coli O104:H4 str. 2011C-3493 ribose ABC transporter permease YP_006781660.1 5215474 R 1133852 CDS YP_006781661.1 407484511 13700871 complement(5216444..5217949) 1 NC_018658.1 COG1129 ABC-type sugar transport system, ATPase component; D-ribose transporter ATP-binding protein 5217949 13700871 O3K_25075 Escherichia coli O104:H4 str. 2011C-3493 D-ribose transporter ATP-binding protein YP_006781661.1 5216444 R 1133852 CDS YP_006781662.1 407484512 13700872 complement(5217957..5218376) 1 NC_018658.1 COG1869 ABC-type ribose transport system, auxiliary component; D-ribose pyranase 5218376 13700872 O3K_25080 Escherichia coli O104:H4 str. 2011C-3493 D-ribose pyranase YP_006781662.1 5217957 R 1133852 CDS YP_006781663.1 407484513 13700873 complement(5218543..5220411) 1 NC_018658.1 COG3158 K+ transporter; potassium transport protein Kup 5220411 trkD 13700873 trkD Escherichia coli O104:H4 str. 2011C-3493 potassium transport protein Kup YP_006781663.1 5218543 R 1133852 CDS YP_006781664.1 407484514 13700874 5220634..5222130 1 NC_018658.1 COG0714 MoxR-like ATPases; regulatory ATPase RavA 5222130 13700874 O3K_25090 Escherichia coli O104:H4 str. 2011C-3493 regulatory ATPase RavA YP_006781664.1 5220634 D 1133852 CDS YP_006781665.1 407484515 13700875 5222124..5223575 1 NC_018658.1 COG2425 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain; hypothetical protein 5223575 13700875 O3K_25095 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781665.1 5222124 D 1133852 CDS YP_006781666.1 407484516 13700876 complement(5223580..5224572) 1 NC_018658.1 COG2502 Asparagine synthetase A; asparagine synthetase AsnA 5224572 13700876 O3K_25100 Escherichia coli O104:H4 str. 2011C-3493 asparagine synthetase AsnA YP_006781666.1 5223580 R 1133852 CDS YP_006781667.1 407484517 13700877 5224724..5225182 1 NC_018658.1 COG1522 Transcriptional regulators; DNA-binding transcriptional regulator AsnC 5225182 13700877 O3K_25105 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator AsnC YP_006781667.1 5224724 D 1133852 CDS YP_006781668.1 407484518 13700878 5225272..5225715 1 NC_018658.1 COG0716 Flavodoxins; FMN-binding protein MioC 5225715 13700878 O3K_25110 Escherichia coli O104:H4 str. 2011C-3493 FMN-binding protein MioC YP_006781668.1 5225272 D 1133852 CDS YP_006781669.1 407484519 13700879 5226094..5227983 1 NC_018658.1 COG0445 NAD/FAD-utilizing enzyme apparently involved in cell division; tRNA uridine 5-carboxymethylaminomethyl modification protein GidA 5227983 13700879 O3K_25115 Escherichia coli O104:H4 str. 2011C-3493 tRNA uridine 5-carboxymethylaminomethyl modification protein GidA YP_006781669.1 5226094 D 1133852 CDS YP_006781670.1 407484520 13700880 5228047..5228670 1 NC_018658.1 COG0357 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division; 16S rRNA methyltransferase GidB 5228670 gidB 13700880 gidB Escherichia coli O104:H4 str. 2011C-3493 16S rRNA methyltransferase GidB YP_006781670.1 5228047 D 1133852 CDS YP_006781671.1 407484521 13700881 5229287..5229667 1 NC_018658.1 F0F1 ATP synthase subunit I 5229667 13700881 O3K_25125 Escherichia coli O104:H4 str. 2011C-3493 F0F1 ATP synthase subunit I YP_006781671.1 5229287 D 1133852 CDS YP_006781672.1 407484522 13700882 5229676..5230491 1 NC_018658.1 COG0356 F0F1-type ATP synthase, subunit a; F0F1 ATP synthase subunit A 5230491 13700882 O3K_25130 Escherichia coli O104:H4 str. 2011C-3493 F0F1 ATP synthase subunit A YP_006781672.1 5229676 D 1133852 CDS YP_006781673.1 407484523 13700883 5230538..5230777 1 NC_018658.1 COG0636 F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K; F0F1 ATP synthase subunit C 5230777 13700883 O3K_25135 Escherichia coli O104:H4 str. 2011C-3493 F0F1 ATP synthase subunit C YP_006781673.1 5230538 D 1133852 CDS YP_006781674.1 407484524 13700884 5230839..5231309 1 NC_018658.1 COG0711 F0F1-type ATP synthase, subunit b; F0F1 ATP synthase subunit B 5231309 13700884 O3K_25140 Escherichia coli O104:H4 str. 2011C-3493 F0F1 ATP synthase subunit B YP_006781674.1 5230839 D 1133852 CDS YP_006781675.1 407484525 13700885 5231324..5231857 1 NC_018658.1 COG0712 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein); F0F1 ATP synthase subunit delta 5231857 13700885 O3K_25145 Escherichia coli O104:H4 str. 2011C-3493 F0F1 ATP synthase subunit delta YP_006781675.1 5231324 D 1133852 CDS YP_006781676.1 407484526 13700886 5231870..5233411 1 NC_018658.1 COG0056 F0F1-type ATP synthase, alpha subunit; F0F1 ATP synthase subunit alpha 5233411 13700886 O3K_25150 Escherichia coli O104:H4 str. 2011C-3493 F0F1 ATP synthase subunit alpha YP_006781676.1 5231870 D 1133852 CDS YP_006781677.1 407484527 13700887 5233462..5234325 1 NC_018658.1 COG0224 F0F1-type ATP synthase, gamma subunit; F0F1 ATP synthase subunit gamma 5234325 13700887 O3K_25155 Escherichia coli O104:H4 str. 2011C-3493 F0F1 ATP synthase subunit gamma YP_006781677.1 5233462 D 1133852 CDS YP_006781678.1 407484528 13700888 5234352..5235734 1 NC_018658.1 COG0055 F0F1-type ATP synthase, beta subunit; F0F1 ATP synthase subunit beta 5235734 13700888 O3K_25160 Escherichia coli O104:H4 str. 2011C-3493 F0F1 ATP synthase subunit beta YP_006781678.1 5234352 D 1133852 CDS YP_006781679.1 407484529 13700889 5235755..5236174 1 NC_018658.1 COG0355 F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit); F0F1 ATP synthase subunit epsilon 5236174 atpC 13700889 atpC Escherichia coli O104:H4 str. 2011C-3493 F0F1 ATP synthase subunit epsilon YP_006781679.1 5235755 D 1133852 CDS YP_006781680.1 407484530 13700890 5236525..5237895 1 NC_018658.1 COG1207 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains); bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 5237895 glmU 13700890 glmU Escherichia coli O104:H4 str. 2011C-3493 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase YP_006781680.1 5236525 D 1133852 CDS YP_006781681.1 407484531 13700891 5238057..5239886 1 NC_018658.1 COG0449 Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains; glucosamine--fructose-6-phosphate aminotransferase 5239886 13700891 O3K_25175 Escherichia coli O104:H4 str. 2011C-3493 glucosamine--fructose-6-phosphate aminotransferase YP_006781681.1 5238057 D 1133852 CDS YP_006781682.1 407484532 13700892 5240188..5240760 1 NC_018658.1 COG3539 P pilus assembly protein, pilin FimA; fimbrial protein 5240760 lpfA 13700892 lpfA Escherichia coli O104:H4 str. 2011C-3493 fimbrial protein YP_006781682.1 5240188 D 1133852 CDS YP_006781683.1 407484533 13700893 5240808..5241539 1 NC_018658.1 COG3121 P pilus assembly protein, chaperone PapD; fimbrial chaperone protein 5241539 lfpB 13700893 lfpB Escherichia coli O104:H4 str. 2011C-3493 fimbrial chaperone protein YP_006781683.1 5240808 D 1133852 CDS YP_006781684.1 407484534 13700894 5241564..5244086 1 NC_018658.1 COG3188 P pilus assembly protein, porin PapC; putative outer membrane usher protein 5244086 13700894 O3K_25190 Escherichia coli O104:H4 str. 2011C-3493 putative outer membrane usher protein YP_006781684.1 5241564 D 1133852 CDS YP_006781685.1 407484535 13700895 5244097..5245170 1 NC_018658.1 fimbrial protein 5245170 13700895 O3K_25195 Escherichia coli O104:H4 str. 2011C-3493 fimbrial protein YP_006781685.1 5244097 D 1133852 CDS YP_006781686.1 407484536 13700896 5245418..5246458 1 NC_018658.1 COG0226 ABC-type phosphate transport system, periplasmic component; phosphate ABC transporter substrate-binding protein 5246458 13700896 O3K_25200 Escherichia coli O104:H4 str. 2011C-3493 phosphate ABC transporter substrate-binding protein YP_006781686.1 5245418 D 1133852 CDS YP_006781687.1 407484537 13700897 5246545..5247504 1 NC_018658.1 COG0573 ABC-type phosphate transport system, permease component; phosphate transporter permease subunit PstC 5247504 pstC 13700897 pstC Escherichia coli O104:H4 str. 2011C-3493 phosphate transporter permease subunit PstC YP_006781687.1 5246545 D 1133852 CDS YP_006781688.1 407484538 13700898 5247504..5248394 1 NC_018658.1 COG0581 ABC-type phosphate transport system, permease component; phosphate transporter permease subunit PtsA 5248394 pstA 13700898 pstA Escherichia coli O104:H4 str. 2011C-3493 phosphate transporter permease subunit PtsA YP_006781688.1 5247504 D 1133852 CDS YP_006781689.1 407484539 13700899 5248485..5249258 1 NC_018658.1 COG1117 ABC-type phosphate transport system, ATPase component; phosphate transporter ATP-binding protein 5249258 pstB 13700899 pstB Escherichia coli O104:H4 str. 2011C-3493 phosphate transporter ATP-binding protein YP_006781689.1 5248485 D 1133852 CDS YP_006781690.1 407484540 13700900 5249273..5249998 1 NC_018658.1 COG0704 Phosphate uptake regulator; transcriptional regulator PhoU 5249998 13700900 O3K_25220 Escherichia coli O104:H4 str. 2011C-3493 transcriptional regulator PhoU YP_006781690.1 5249273 D 1133852 CDS YP_006781691.1 407484541 13700901 5251254..5253131 1 NC_018658.1 COG1264 Phosphotransferase system IIB components; PTS system beta-glucoside-specific transporter subunit IIABC 5253131 13700901 O3K_25235 Escherichia coli O104:H4 str. 2011C-3493 PTS system beta-glucoside-specific transporter subunit IIABC YP_006781691.1 5251254 D 1133852 CDS YP_006781692.1 407484542 13700902 5253150..5254544 1 NC_018658.1 COG2723 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase; cryptic phospho-beta-glucosidase B 5254544 13700902 O3K_25240 Escherichia coli O104:H4 str. 2011C-3493 cryptic phospho-beta-glucosidase B YP_006781692.1 5253150 D 1133852 CDS YP_006781693.1 407484543 13700903 5254630..5256246 1 NC_018658.1 COG4580 Maltoporin (phage lambda and maltose receptor); carbohydrate-specific outer membrane porin, cryptic 5256246 13700903 O3K_25245 Escherichia coli O104:H4 str. 2011C-3493 carbohydrate-specific outer membrane porin, cryptic YP_006781693.1 5254630 D 1133852 CDS YP_006781694.1 407484544 13700904 5256273..5257442 1 NC_018658.1 COG2382 Enterochelin esterase and related enzymes; xylanase 5257442 13700904 O3K_25250 Escherichia coli O104:H4 str. 2011C-3493 xylanase YP_006781694.1 5256273 D 1133852 CDS YP_006781695.1 407484545 13700905 5257457..5258179 1 NC_018658.1 COG0363 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase; putative 6-phosphogluconolactonase 5258179 13700905 O3K_25255 Escherichia coli O104:H4 str. 2011C-3493 putative 6-phosphogluconolactonase YP_006781695.1 5257457 D 1133852 CDS YP_006781696.1 407484546 13700906 complement(5258241..5258828) 1 NC_018658.1 COG3196 Uncharacterized protein conserved in bacteria; hypothetical protein 5258828 13700906 O3K_25260 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781696.1 5258241 R 1133852 CDS YP_006781697.1 407484547 13700907 complement(5258877..5259350) 1 NC_018658.1 inner membrane protein 5259350 13700907 O3K_25265 Escherichia coli O104:H4 str. 2011C-3493 inner membrane protein YP_006781697.1 5258877 R 1133852 CDS YP_006781698.1 407484548 13700908 complement(5259417..5260082) 1 NC_018658.1 COG0637 Predicted phosphatase/phosphohexomutase; 6-phosphogluconate phosphatase 5260082 13700908 O3K_25270 Escherichia coli O104:H4 str. 2011C-3493 6-phosphogluconate phosphatase YP_006781698.1 5259417 R 1133852 CDS YP_006781699.1 407484549 13700909 5260249..5261586 1 NC_018658.1 COG2252 Permeases; hypothetical protein 5261586 13700909 O3K_25275 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781699.1 5260249 D 1133852 CDS YP_006781700.1 407484550 13700910 complement(5261640..5262206) 1 NC_018658.1 COG0431 Predicted flavoprotein; hypothetical protein 5262206 13700910 O3K_25280 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781700.1 5261640 R 1133852 CDS YP_006781701.1 407484551 13700911 complement(5262228..5262977) 1 NC_018658.1 COG2091 Phosphopantetheinyl transferase; phosphopantetheinyl transferase 5262977 13700911 O3K_25285 Escherichia coli O104:H4 str. 2011C-3493 phosphopantetheinyl transferase YP_006781701.1 5262228 R 1133852 CDS YP_006781702.1 407484552 13700912 complement(5263134..5264093) 1 NC_018658.1 COG0583 Transcriptional regulator; DNA-binding transcriptional regulator YidZ 5264093 13700912 O3K_25290 Escherichia coli O104:H4 str. 2011C-3493 DNA-binding transcriptional regulator YidZ YP_006781702.1 5263134 R 1133852 CDS YP_006781703.1 407484553 13700913 complement(5264068..5265243) 1 NC_018658.1 COG0477 Permeases of the major facilitator superfamily; multidrug efflux system protein MdtL 5265243 13700913 O3K_25295 Escherichia coli O104:H4 str. 2011C-3493 multidrug efflux system protein MdtL YP_006781703.1 5264068 R 1133852 CDS YP_006781704.1 407484554 13700914 complement(5265376..5266623) 1 NC_018658.1 COG0814 Amino acid permeases; tryptophan permease TnaB 5266623 13700914 O3K_25300 Escherichia coli O104:H4 str. 2011C-3493 tryptophan permease TnaB YP_006781704.1 5265376 R 1133852 CDS YP_006781705.1 407484555 13700915 complement(5266714..5268129) 1 NC_018658.1 COG3033 Tryptophanase; tryptophanase/L-cysteine desulfhydrase, PLP-dependent 5268129 tnaA 13700915 tnaA Escherichia coli O104:H4 str. 2011C-3493 tryptophanase/L-cysteine desulfhydrase, PLP-dependent YP_006781705.1 5266714 R 1133852 CDS YP_006781706.1 407484556 13700916 complement(5268350..5268424) 1 NC_018658.1 tryptophanase leader peptide 5268424 13700916 O3K_25310 Escherichia coli O104:H4 str. 2011C-3493 tryptophanase leader peptide YP_006781706.1 5268350 R 1133852 CDS YP_006781707.1 407484557 13700917 complement(5268667..5270031) 1 NC_018658.1 COG0486 Predicted GTPase; tRNA modification GTPase TrmE 5270031 trmE 13700917 trmE Escherichia coli O104:H4 str. 2011C-3493 tRNA modification GTPase TrmE YP_006781707.1 5268667 R 1133852 CDS YP_006781708.1 407484558 13700918 complement(5270137..5271783) 1 NC_018658.1 COG0706 Preprotein translocase subunit YidC; membrane protein insertase 5271783 13700918 O3K_25320 Escherichia coli O104:H4 str. 2011C-3493 membrane protein insertase YP_006781708.1 5270137 R 1133852 CDS YP_006781709.1 407484559 13700919 complement(5271786..5272043) 1 NC_018658.1 COG0759 Uncharacterized conserved protein; hypothetical protein 5272043 13700919 O3K_25325 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781709.1 5271786 R 1133852 CDS YP_006781710.1 407484560 13700920 complement(5272007..5272366) 1 NC_018658.1 COG0594 RNase P protein component; ribonuclease P 5272366 rnpA 13700920 rnpA Escherichia coli O104:H4 str. 2011C-3493 ribonuclease P YP_006781710.1 5272007 R 1133852 CDS YP_006781711.1 407484561 13700921 complement(5272383..5272523) 1 NC_018658.1 COG0230 Ribosomal protein L34; 50S ribosomal protein L34 5272523 rpmH 13700921 rpmH Escherichia coli O104:H4 str. 2011C-3493 50S ribosomal protein L34 YP_006781711.1 5272383 R 1133852 CDS YP_006781712.1 407484676 13703856 complement(join(86977..88544,1..1477)) 1 NC_018659.1 TraU protein 1477 13703856 O3K_25572 Escherichia coli O104:H4 str. 2011C-3493 TraU protein YP_006781712.1 86977 R 1133852 CDS YP_006781713.1 407484677 13703764 complement(1567..2367) 1 NC_018659.1 TraT transfer protein 2367 13703764 O3K_25577 Escherichia coli O104:H4 str. 2011C-3493 TraT transfer protein YP_006781713.1 1567 R 1133852 CDS YP_006781714.1 407484678 13703857 complement(2351..2539) 1 NC_018659.1 TraS transfer protein 2539 13703857 O3K_25582 Escherichia coli O104:H4 str. 2011C-3493 TraS transfer protein YP_006781714.1 2351 R 1133852 CDS YP_006781715.1 407484679 13703765 complement(2603..3007) 1 NC_018659.1 hypothetical protein 3007 13703765 O3K_25587 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781715.1 2603 R 1133852 CDS YP_006781716.1 407484680 13703766 complement(3058..3585) 1 NC_018659.1 TraQ protein 3585 13703766 O3K_25592 Escherichia coli O104:H4 str. 2011C-3493 TraQ protein YP_006781716.1 3058 R 1133852 CDS YP_006781717.1 407484681 13703767 complement(3585..4289) 1 NC_018659.1 hypothetical protein 4289 13703767 O3K_25597 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781717.1 3585 R 1133852 CDS YP_006781718.1 407484682 13703768 complement(4289..5578) 1 NC_018659.1 hypothetical protein 5578 13703768 O3K_25602 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781718.1 4289 R 1133852 CDS YP_006781719.1 407484683 13703769 complement(5581..6564) 1 NC_018659.1 hypothetical protein 6564 13703769 O3K_25607 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781719.1 5581 R 1133852 CDS YP_006781720.1 407484684 13703770 complement(6575..7267) 1 NC_018659.1 TraM protein 7267 13703770 O3K_25612 Escherichia coli O104:H4 str. 2011C-3493 TraM protein YP_006781720.1 6575 R 1133852 CDS YP_006781721.1 407484685 13703771 complement(7264..7611) 1 NC_018659.1 F pilus assembly 7611 13703771 O3K_25617 Escherichia coli O104:H4 str. 2011C-3493 F pilus assembly YP_006781721.1 7264 R 1133852 CDS YP_006781722.1 407484686 13703772 complement(7629..11393) 1 NC_018659.1 COG4643 Uncharacterized protein conserved in bacteria; SogL protein 11393 13703772 O3K_25622 Escherichia coli O104:H4 str. 2011C-3493 SogL protein YP_006781722.1 7629 R 1133852 CDS YP_006781723.1 407484687 13703773 complement(11483..12034) 1 NC_018659.1 COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipi n synthases and related enzymes; EDTA-resistant nuclease 12034 13703773 O3K_25627 Escherichia coli O104:H4 str. 2011C-3493 EDTA-resistant nuclease YP_006781723.1 11483 R 1133852 CDS YP_006781724.1 407484688 13703774 complement(12336..13484) 1 NC_018659.1 COG2805 Tfp pilus assembly protein, pilus retraction ATPase PilT; TraJ transfer ATPase 13484 13703774 O3K_25632 Escherichia coli O104:H4 str. 2011C-3493 TraJ transfer ATPase YP_006781724.1 12336 R 1133852 CDS YP_006781725.1 407484689 13703775 complement(13481..14299) 1 NC_018659.1 lipoprotein 14299 13703775 O3K_25637 Escherichia coli O104:H4 str. 2011C-3493 lipoprotein YP_006781725.1 13481 R 1133852 CDS YP_006781726.1 407484690 13703776 complement(14296..14754) 1 NC_018659.1 TraH lipoprotein 14754 13703776 O3K_25642 Escherichia coli O104:H4 str. 2011C-3493 TraH lipoprotein YP_006781726.1 14296 R 1133852 CDS YP_006781727.1 407484691 13703777 complement(15149..15733) 1 NC_018659.1 lipopolysaccharide core heptose(II)-phosphate phosphatase 15733 13703777 O3K_25647 Escherichia coli O104:H4 str. 2011C-3493 lipopolysaccharide core heptose(II)-phosphate phosphatase YP_006781727.1 15149 R 1133852 CDS YP_006781728.1 407484692 13703778 complement(15793..16995) 1 NC_018659.1 F pilus assembly 16995 13703778 O3K_25652 Escherichia coli O104:H4 str. 2011C-3493 F pilus assembly YP_006781728.1 15793 R 1133852 CDS YP_006781729.1 407484693 13703779 complement(17081..17905) 1 NC_018659.1 COG0457 FOG: TPR repeat; F pilus assembly 17905 13703779 O3K_25657 Escherichia coli O104:H4 str. 2011C-3493 F pilus assembly YP_006781729.1 17081 R 1133852 CDS YP_006781730.1 407484694 13703780 complement(18056..19210) 1 NC_018659.1 COG0582 Integrase; shufflon-specific DNA recombinase 19210 13703780 O3K_25662 Escherichia coli O104:H4 str. 2011C-3493 shufflon-specific DNA recombinase YP_006781730.1 18056 R 1133852 CDS YP_006781731.1 407484695 13703781 20231..20350 1 NC_018659.1 putative PilVB C-terminal segment; hypothetical protein 20350 13703781 O3K_25667 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781731.1 20231 D 1133852 CDS YP_006781732.1 407484696 13703782 complement(20375..20581) 1 NC_018659.1 hypothetical protein 20581 13703782 O3K_25672 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781732.1 20375 R 1133852 CDS YP_006781733.1 407484697 13703783 complement(20844..22280) 1 NC_018659.1 shufflon protein A 22280 13703783 O3K_25677 Escherichia coli O104:H4 str. 2011C-3493 shufflon protein A YP_006781733.1 20844 R 1133852 CDS YP_006781734.1 407484698 13703784 complement(22268..22924) 1 NC_018659.1 COG1989 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases; PilU prepilin peptidase 22924 13703784 O3K_25682 Escherichia coli O104:H4 str. 2011C-3493 PilU prepilin peptidase YP_006781734.1 22268 R 1133852 CDS YP_006781735.1 407484699 13703785 complement(22909..23469) 1 NC_018659.1 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains); type IV prepilin cluster 23469 13703785 O3K_25687 Escherichia coli O104:H4 str. 2011C-3493 type IV prepilin cluster YP_006781735.1 22909 R 1133852 CDS YP_006781736.1 407484700 13703786 complement(23479..24093) 1 NC_018659.1 type IV prepilin cluster, prepilin 24093 13703786 O3K_25692 Escherichia coli O104:H4 str. 2011C-3493 type IV prepilin cluster, prepilin YP_006781736.1 23479 R 1133852 CDS YP_006781737.1 407484701 13703787 complement(24110..25195) 1 NC_018659.1 COG1459 Type II secretory pathway, component PulF; putative transmembrane protein 25195 13703787 O3K_25697 Escherichia coli O104:H4 str. 2011C-3493 putative transmembrane protein YP_006781737.1 24110 R 1133852 CDS YP_006781738.1 407484702 13703788 complement(25208..26761) 1 NC_018659.1 COG2804 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB; type IV prepilin cluster, ATP-binding protein 26761 13703788 O3K_25702 Escherichia coli O104:H4 str. 2011C-3493 type IV prepilin cluster, ATP-binding protein YP_006781738.1 25208 R 1133852 CDS YP_006781739.1 407484703 13703789 complement(26772..27224) 1 NC_018659.1 putative conjugative transfer PilP protein 27224 13703789 O3K_25707 Escherichia coli O104:H4 str. 2011C-3493 putative conjugative transfer PilP protein YP_006781739.1 26772 R 1133852 CDS YP_006781740.1 407484704 13703790 complement(27211..28506) 1 NC_018659.1 PilO protein 28506 13703790 O3K_25712 Escherichia coli O104:H4 str. 2011C-3493 PilO protein YP_006781740.1 27211 R 1133852 CDS YP_006781741.1 407484705 13703791 complement(28499..30181) 1 NC_018659.1 COG1450 Type II secretory pathway, component PulD; PilN type IV pilus secretin 30181 13703791 O3K_25717 Escherichia coli O104:H4 str. 2011C-3493 PilN type IV pilus secretin YP_006781741.1 28499 R 1133852 CDS YP_006781742.1 407484706 13703792 complement(30195..30632) 1 NC_018659.1 PilM type IV pilus biogenesis protein 30632 13703792 O3K_25722 Escherichia coli O104:H4 str. 2011C-3493 PilM type IV pilus biogenesis protein YP_006781742.1 30195 R 1133852 CDS YP_006781743.1 407484707 13703793 complement(30632..31699) 1 NC_018659.1 lipoprotein PilL 31699 13703793 O3K_25727 Escherichia coli O104:H4 str. 2011C-3493 lipoprotein PilL YP_006781743.1 30632 R 1133852 CDS YP_006781744.1 407484708 13703794 complement(32746..33045) 1 NC_018659.1 hypothetical protein 33045 13703794 O3K_25732 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781744.1 32746 R 1133852 CDS YP_006781745.1 407484709 13703795 complement(33172..33855) 1 NC_018659.1 TraC 33855 13703795 O3K_25737 Escherichia coli O104:H4 str. 2011C-3493 TraC YP_006781745.1 33172 R 1133852 CDS YP_006781746.1 407484710 13703796 complement(34109..34642) 1 NC_018659.1 COG0250 Transcription antiterminator; TraB protein 34642 13703796 O3K_25742 Escherichia coli O104:H4 str. 2011C-3493 TraB protein YP_006781746.1 34109 R 1133852 CDS YP_006781747.1 407484711 13703797 complement(35084..35371) 1 NC_018659.1 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; protein TraA 35371 13703797 O3K_25747 Escherichia coli O104:H4 str. 2011C-3493 protein TraA YP_006781747.1 35084 R 1133852 CDS YP_006781748.1 407484712 13703798 complement(35289..35552) 1 NC_018659.1 hypothetical protein 35552 13703798 O3K_25752 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781748.1 35289 R 1133852 CDS YP_006781749.1 407484713 13703799 36525..37556 1 NC_018659.1 COG1132 ABC-type multidrug transport system, ATPase and permease components; replication initiation protein 37556 13703799 O3K_25757 Escherichia coli O104:H4 str. 2011C-3493 replication initiation protein YP_006781749.1 36525 D 1133852 CDS YP_006781750.1 407484714 13703800 complement(38626..39135) 1 NC_018659.1 protein YafA 39135 13703800 O3K_25762 Escherichia coli O104:H4 str. 2011C-3493 protein YafA YP_006781750.1 38626 R 1133852 CDS YP_006781751.1 407484715 13703801 complement(39191..39793) 1 NC_018659.1 COG3109 Activator of osmoprotectant transporter ProP; hypothetical protein 39793 13703801 O3K_25767 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781751.1 39191 R 1133852 CDS YP_006781752.1 407484716 13703802 40146..41492 1 NC_018659.1 hypothetical protein 41492 13703802 O3K_25772 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781752.1 40146 D 1133852 CDS YP_006781753.1 407484717 13703803 complement(41980..44454) 1 NC_018659.1 COG4644 Transposase and inactivated derivatives, TnpA family; hypothetical protein 44454 13703803 O3K_25777 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781753.1 41980 R 1133852 CDS YP_006781754.1 407484718 13703804 44849..45121 1 NC_018659.1 hypothetical protein 45121 13703804 O3K_25782 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781754.1 44849 D 1133852 CDS YP_006781755.1 407484719 13703805 complement(45168..46043) 1 NC_018659.1 COG2367 Beta-lactamase class A; beta-lactamase 46043 13703805 O3K_25787 Escherichia coli O104:H4 str. 2011C-3493 beta-lactamase YP_006781755.1 45168 R 1133852 CDS YP_006781756.1 407484720 13703806 complement(46196..46318) 1 NC_018659.1 hypothetical protein 46318 13703806 O3K_25792 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781756.1 46196 R 1133852 CDS YP_006781757.1 407484721 13703807 complement(46299..47561) 1 NC_018659.1 ISEcp1 transposase 47561 13703807 O3K_25797 Escherichia coli O104:H4 str. 2011C-3493 ISEcp1 transposase YP_006781757.1 46299 R 1133852 CDS YP_006781758.1 407484722 13703808 complement(47743..47961) 1 NC_018659.1 COG4644 Transposase and inactivated derivatives, TnpA family; transposase 47961 13703808 O3K_25802 Escherichia coli O104:H4 str. 2011C-3493 transposase YP_006781758.1 47743 R 1133852 CDS YP_006781759.1 407484723 13703809 48125..48682 1 NC_018659.1 COG1961 Site-specific recombinases, DNA invertase Pin homologs; Tn3 resolvase 48682 13703809 O3K_25807 Escherichia coli O104:H4 str. 2011C-3493 Tn3 resolvase YP_006781759.1 48125 D 1133852 CDS YP_006781760.1 407484724 13703810 48865..49725 1 NC_018659.1 COG2367 Beta-lactamase class A; beta-lactamase TEM 49725 13703810 O3K_25812 Escherichia coli O104:H4 str. 2011C-3493 beta-lactamase TEM YP_006781760.1 48865 D 1133852 CDS YP_006781761.1 407484725 13703811 complement(49994..50296) 1 NC_018659.1 hypothetical protein 50296 13703811 O3K_25817 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781761.1 49994 R 1133852 CDS YP_006781762.1 407484726 13703812 complement(50293..50826) 1 NC_018659.1 COG1192 ATPases involved in chromosome partitioning; Type II plasmid partioning protein 50826 13703812 O3K_25822 Escherichia coli O104:H4 str. 2011C-3493 Type II plasmid partioning protein YP_006781762.1 50293 R 1133852 CDS YP_006781763.1 407484727 13703813 complement(51123..52394) 1 NC_018659.1 COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair; DNA polymerase V subunit UmuC 52394 umuC 13703813 umuC Escherichia coli O104:H4 str. 2011C-3493 DNA polymerase V subunit UmuC YP_006781763.1 51123 R 1133852 CDS YP_006781764.1 407484728 13703814 complement(52394..52831) 1 NC_018659.1 COG1974 SOS-response transcriptional repressors (RecA-mediated autopeptidases); DNA polymerase V subunit ImpA 52831 13703814 O3K_25832 Escherichia coli O104:H4 str. 2011C-3493 DNA polymerase V subunit ImpA YP_006781764.1 52394 R 1133852 CDS YP_006781765.1 407484729 13703815 complement(52828..53076) 1 NC_018659.1 hypothetical protein 53076 13703815 O3K_25837 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781765.1 52828 R 1133852 CDS YP_006781766.1 407484730 13703816 53471..54397 1 NC_018659.1 hypothetical protein 54397 13703816 O3K_25842 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781766.1 53471 D 1133852 CDS YP_006781767.1 407484731 13703817 54782..55465 1 NC_018659.1 COG0863 DNA modification methylase; putative methylase 55465 13703817 O3K_25847 Escherichia coli O104:H4 str. 2011C-3493 putative methylase YP_006781767.1 54782 D 1133852 CDS YP_006781768.1 407484732 13703818 55466..55687 1 NC_018659.1 hypothetical protein 55687 13703818 O3K_25852 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781768.1 55466 D 1133852 CDS YP_006781769.1 407484733 13703819 55701..56135 1 NC_018659.1 hypothetical protein 56135 13703819 O3K_25857 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781769.1 55701 D 1133852 CDS YP_006781770.1 407484734 13703820 56181..56957 1 NC_018659.1 YchA 56957 13703820 O3K_25862 Escherichia coli O104:H4 str. 2011C-3493 YchA YP_006781770.1 56181 D 1133852 CDS YP_006781771.1 407484735 13703821 57371..57796 1 NC_018659.1 COG0587 DNA polymerase III, alpha subunit; antirestriction protein 57796 13703821 O3K_25867 Escherichia coli O104:H4 str. 2011C-3493 antirestriction protein YP_006781771.1 57371 D 1133852 CDS YP_006781772.1 407484736 13703822 57843..58265 1 NC_018659.1 hypothetical protein 58265 13703822 O3K_25872 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781772.1 57843 D 1133852 CDS YP_006781773.1 407484737 13703823 58262..58453 1 NC_018659.1 hypothetical protein 58453 13703823 O3K_25877 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781773.1 58262 D 1133852 CDS YP_006781774.1 407484738 13703824 59222..59749 1 NC_018659.1 COG0629 Single-stranded DNA-binding protein; single-stranded DNA-binding protein 59749 13703824 O3K_25882 Escherichia coli O104:H4 str. 2011C-3493 single-stranded DNA-binding protein YP_006781774.1 59222 D 1133852 CDS YP_006781775.1 407484739 13703825 59807..60040 1 NC_018659.1 hypothetical protein 60040 13703825 O3K_25887 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781775.1 59807 D 1133852 CDS YP_006781776.1 407484740 13703826 60099..62057 1 NC_018659.1 COG1475 Predicted transcriptional regulators; Type II plasmid partioning protein 62057 13703826 O3K_25892 Escherichia coli O104:H4 str. 2011C-3493 Type II plasmid partioning protein YP_006781776.1 60099 D 1133852 CDS YP_006781777.1 407484741 13703827 62112..62546 1 NC_018659.1 plasmid SOS inhibition protein B 62546 psiB 13703827 psiB Escherichia coli O104:H4 str. 2011C-3493 plasmid SOS inhibition protein B YP_006781777.1 62112 D 1133852 CDS YP_006781778.1 407484742 13703828 62543..63262 1 NC_018659.1 plasmid SOS inhibition protein A 63262 13703828 O3K_25902 Escherichia coli O104:H4 str. 2011C-3493 plasmid SOS inhibition protein A YP_006781778.1 62543 D 1133852 CDS YP_006781779.1 407484743 13703829 63259..63855 1 NC_018659.1 YgaA 63855 13703829 O3K_25907 Escherichia coli O104:H4 str. 2011C-3493 YgaA YP_006781779.1 63259 D 1133852 CDS YP_006781780.1 407484744 13703830 64317..64817 1 NC_018659.1 COG4734 Antirestriction protein; anti-restriction protein 64817 13703830 O3K_25912 Escherichia coli O104:H4 str. 2011C-3493 anti-restriction protein YP_006781780.1 64317 D 1133852 CDS YP_006781781.1 407484745 13703831 65546..65980 1 NC_018659.1 hypothetical protein 65980 13703831 O3K_25917 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781781.1 65546 D 1133852 CDS YP_006781782.1 407484746 13703832 66074..66340 1 NC_018659.1 hypothetical protein 66340 13703832 O3K_25922 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781782.1 66074 D 1133852 CDS YP_006781783.1 407484747 13703833 66517..66906 1 NC_018659.1 hypothetical protein 66906 13703833 O3K_25927 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781783.1 66517 D 1133852 CDS YP_006781784.1 407484748 13703834 66903..67817 1 NC_018659.1 COG5464 Uncharacterized conserved protein; hypothetical protein 67817 13703834 O3K_25932 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781784.1 66903 D 1133852 CDS YP_006781785.1 407484749 13703835 67879..68085 1 NC_018659.1 COG5464 Uncharacterized conserved protein; hypothetical protein 68085 13703835 O3K_25937 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781785.1 67879 D 1133852 CDS YP_006781786.1 407484750 13703836 complement(68116..68367) 1 NC_018659.1 hypothetical protein 68367 13703836 O3K_25942 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781786.1 68116 R 1133852 CDS YP_006781787.1 407484751 13703837 68947..69795 1 NC_018659.1 hypothetical protein 69795 13703837 O3K_25947 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781787.1 68947 D 1133852 CDS YP_006781788.1 407484752 13703838 complement(69882..70217) 1 NC_018659.1 protein YggA 70217 13703838 O3K_25952 Escherichia coli O104:H4 str. 2011C-3493 protein YggA YP_006781788.1 69882 R 1133852 CDS YP_006781789.1 407484753 13703839 70451..70783 1 NC_018659.1 relaxosome component 70783 13703839 O3K_25957 Escherichia coli O104:H4 str. 2011C-3493 relaxosome component YP_006781789.1 70451 D 1133852 CDS YP_006781790.1 407484754 13703840 70794..73493 1 NC_018659.1 relaxase 73493 13703840 O3K_25962 Escherichia coli O104:H4 str. 2011C-3493 relaxase YP_006781790.1 70794 D 1133852 CDS YP_006781791.1 407484755 13703841 complement(73530..75821) 1 NC_018659.1 IcmO-like type IV secretion system protein 75821 13703841 O3K_25967 Escherichia coli O104:H4 str. 2011C-3493 IcmO-like type IV secretion system protein YP_006781791.1 73530 R 1133852 CDS YP_006781792.1 407484756 13703842 complement(75814..76884) 1 NC_018659.1 COG1651 Protein-disulfide isomerase; hypothetical protein 76884 13703842 O3K_25972 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781792.1 75814 R 1133852 CDS YP_006781793.1 407484757 13703843 complement(76903..78111) 1 NC_018659.1 hypothetical protein 78111 13703843 O3K_25977 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781793.1 76903 R 1133852 CDS YP_006781794.1 407484758 13703844 complement(78418..79503) 1 NC_018659.1 fertility inhibition protein 79503 13703844 O3K_25982 Escherichia coli O104:H4 str. 2011C-3493 fertility inhibition protein YP_006781794.1 78418 R 1133852 CDS YP_006781795.1 407484759 13703845 79821..79976 1 NC_018659.1 hypothetical protein 79976 13703845 O3K_25987 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781795.1 79821 D 1133852 CDS YP_006781796.1 407484760 13703846 complement(80048..80299) 1 NC_018659.1 hypothetical protein 80299 13703846 O3K_25992 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781796.1 80048 R 1133852 CDS YP_006781797.1 407484761 13703847 80599..80895 1 NC_018659.1 hypothetical protein 80895 13703847 O3K_25997 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781797.1 80599 D 1133852 CDS YP_006781798.1 407484762 13703848 complement(80960..81136) 1 NC_018659.1 hypothetical protein 81136 13703848 O3K_26002 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781798.1 80960 R 1133852 CDS YP_006781799.1 407484763 13703849 complement(81133..81276) 1 NC_018659.1 hypothetical protein 81276 13703849 O3K_26007 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006781799.1 81133 R 1133852 CDS YP_006781800.1 407484764 13703850 complement(81319..81528) 1 NC_018659.1 putative regulator protein 81528 13703850 O3K_26012 Escherichia coli O104:H4 str. 2011C-3493 putative regulator protein YP_006781800.1 81319 R 1133852 CDS YP_006781801.1 407484765 13703851 complement(81626..82240) 1 NC_018659.1 surface exclusion protein 82240 13703851 O3K_26017 Escherichia coli O104:H4 str. 2011C-3493 surface exclusion protein YP_006781801.1 81626 R 1133852 CDS YP_006781802.1 407484766 13703852 complement(82316..84553) 1 NC_018659.1 TraY integral membrane protein 84553 13703852 O3K_26022 Escherichia coli O104:H4 str. 2011C-3493 TraY integral membrane protein YP_006781802.1 82316 R 1133852 CDS YP_006781803.1 407484767 13703853 complement(84581..85165) 1 NC_018659.1 F pilin acetylation protein 85165 13703853 O3K_26027 Escherichia coli O104:H4 str. 2011C-3493 F pilin acetylation protein YP_006781803.1 84581 R 1133852 CDS YP_006781804.1 407484768 13703854 complement(85194..86396) 1 NC_018659.1 F pilus assembly 86396 13703854 O3K_26032 Escherichia coli O104:H4 str. 2011C-3493 F pilus assembly YP_006781804.1 85194 R 1133852 CDS YP_006781805.1 407484769 13703855 complement(86363..86977) 1 NC_018659.1 F pilus assembly 86977 13703855 O3K_26037 Escherichia coli O104:H4 str. 2011C-3493 F pilus assembly YP_006781805.1 86363 R 1133852 CDS YP_006781806.1 407484774 13703859 join(1313..1549,1..240) 1 NC_018660.1 plasmid replication protein 240 13703859 O3K_26522 Escherichia coli O104:H4 str. 2011C-3493 plasmid replication protein YP_006781806.1 1313 D 1133852 CDS YP_006792544.1 407484806 13715097 complement(757..1737) 1 NC_018666.1 COG3039 Transposase and inactivated derivatives, IS5 family; transposase 1737 13715097 O3K_26057 Escherichia coli O104:H4 str. 2011C-3493 transposase YP_006792544.1 757 R 1133852 CDS YP_006792545.1 407484807 13715016 1736..1870 1 NC_018666.1 hypothetical protein 1870 13715016 O3K_26062 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006792545.1 1736 D 1133852 CDS YP_006792546.1 407484808 13715017 complement(3211..4734) 1 NC_018666.1 COG3344 Retron-type reverse transcriptase; reverse transcriptase-like protein, CP4-6 prophage (modular protein) 4734 13715017 O3K_26077 Escherichia coli O104:H4 str. 2011C-3493 reverse transcriptase-like protein, CP4-6 prophage (modular protein) YP_006792546.1 3211 R 1133852 CDS YP_006792547.1 407484809 13715019 complement(5805..6131) 1 NC_018666.1 COG2963 Transposase and inactivated derivatives; IS629 protein 6131 13715019 O3K_26087 Escherichia coli O104:H4 str. 2011C-3493 IS629 protein YP_006792547.1 5805 R 1133852 CDS YP_006792548.1 407484810 13715020 6865..7662 1 NC_018666.1 COG2207 AraC-type DNA-binding domain-containing proteins; putative transcriptional activator aggR (AAF-III) regulatory protein 7662 13715020 O3K_26097 Escherichia coli O104:H4 str. 2011C-3493 putative transcriptional activator aggR (AAF-III) regulatory protein YP_006792548.1 6865 D 1133852 CDS YP_006792549.1 407484811 13715021 7763..8167 1 NC_018666.1 COG3677 Transposase and inactivated derivatives; IS1; transposase ORF A, IS1 8167 13715021 O3K_26102 Escherichia coli O104:H4 str. 2011C-3493 transposase ORF A, IS1 YP_006792549.1 7763 D 1133852 CDS YP_006792550.1 407484812 13715022 complement(8410..9234) 1 NC_018666.1 COG3547 Transposase and inactivated derivatives; transposase 9234 13715022 O3K_26107 Escherichia coli O104:H4 str. 2011C-3493 transposase YP_006792550.1 8410 R 1133852 CDS YP_006792551.1 407484813 13715023 complement(9596..10576) 1 NC_018666.1 COG3039 Transposase and inactivated derivatives, IS5 family; transposase 10576 13715023 O3K_26112 Escherichia coli O104:H4 str. 2011C-3493 transposase YP_006792551.1 9596 R 1133852 CDS YP_006792552.1 407484814 13715024 10575..10736 1 NC_018666.1 hypothetical protein 10736 13715024 O3K_26117 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006792552.1 10575 D 1133852 CDS YP_006792553.1 407484815 13715025 10736..10888 1 NC_018666.1 hypothetical protein 10888 13715025 O3K_26122 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006792553.1 10736 D 1133852 CDS YP_006792554.1 407484816 13715026 complement(11391..11678) 1 NC_018666.1 IPP:Isopentenyl pyrophosphate isomerase; IPP:DMAPP isomerase; COG1443 Isopentenyldiphosphate isomerase; putative Isopentenyl-diphosphate delta-isomerase 11678 13715026 O3K_26127 Escherichia coli O104:H4 str. 2011C-3493 putative Isopentenyl-diphosphate delta-isomerase YP_006792554.1 11391 R 1133852 CDS YP_006792555.1 407484817 13715027 complement(11687..11911) 1 NC_018666.1 hypothetical protein 11911 13715027 O3K_26132 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006792555.1 11687 R 1133852 CDS YP_006792556.1 407484818 13715028 complement(11934..12962) 1 NC_018666.1 hypothetical protein 12962 13715028 O3K_26137 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006792556.1 11934 R 1133852 CDS YP_006792557.1 407484819 13715029 13398..13898 1 NC_018666.1 COG2963 Transposase and inactivated derivatives; putative ISRSO11-transposase orfA protein 13898 13715029 O3K_26147 Escherichia coli O104:H4 str. 2011C-3493 putative ISRSO11-transposase orfA protein YP_006792557.1 13398 D 1133852 CDS YP_006792558.1 407484820 13715030 14141..14329 1 NC_018666.1 COG2801 Transposase and inactivated derivatives; IS150 ORF B; transposase 14329 13715030 O3K_26152 Escherichia coli O104:H4 str. 2011C-3493 transposase YP_006792558.1 14141 D 1133852 CDS YP_006792559.1 407484821 13715031 complement(14354..14578) 1 NC_018666.1 COG2801 Transposase and inactivated derivatives; hypothetical protein 14578 13715031 O3K_26157 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006792559.1 14354 R 1133852 CDS YP_006792560.1 407484822 13715032 14623..14880 1 NC_018666.1 COG2801 Transposase and inactivated derivatives; ISEhe3 orfB 14880 13715032 O3K_26162 Escherichia coli O104:H4 str. 2011C-3493 ISEhe3 orfB YP_006792560.1 14623 D 1133852 CDS YP_006792561.1 407484823 13715033 complement(16503..16850) 1 NC_018666.1 COG3436 Transposase and inactivated derivatives; putative transposase 16850 13715033 O3K_26177 Escherichia coli O104:H4 str. 2011C-3493 putative transposase YP_006792561.1 16503 R 1133852 CDS YP_006792562.1 407484824 13715034 complement(16847..17248) 1 NC_018666.1 COG2963 Transposase and inactivated derivatives; hypothetical protein 17248 13715034 O3K_26182 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006792562.1 16847 R 1133852 CDS YP_006792563.1 407484825 13715035 17434..17595 1 NC_018666.1 COG3464 Transposase and inactivated derivatives; hypothetical protein 17595 13715035 O3K_26187 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006792563.1 17434 D 1133852 CDS YP_006792564.1 407484826 13715036 complement(17564..17884) 1 NC_018666.1 COG4584 Transposase and inactivated derivatives; putative transposase 17884 13715036 O3K_26192 Escherichia coli O104:H4 str. 2011C-3493 putative transposase YP_006792564.1 17564 R 1133852 CDS YP_006792565.1 407484827 13715037 complement(18021..18524) 1 NC_018666.1 hypothetical protein 18524 13715037 O3K_26197 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006792565.1 18021 R 1133852 CDS YP_006792566.1 407484828 13715038 complement(18626..19063) 1 NC_018666.1 Protein Agg3B, putative invasin 19063 13715038 O3K_26202 Escherichia coli O104:H4 str. 2011C-3493 Protein Agg3B, putative invasin YP_006792566.1 18626 R 1133852 CDS YP_006792567.1 407484829 13715039 complement(19077..21461) 1 NC_018666.1 COG3188 P pilus assembly protein, porin PapC; Outer membrane usher protein Agg3C 21461 13715039 O3K_26207 Escherichia coli O104:H4 str. 2011C-3493 Outer membrane usher protein Agg3C YP_006792567.1 19077 R 1133852 CDS YP_006792568.1 407484830 13715040 complement(21619..22248) 1 NC_018666.1 COG3121 P pilus assembly protein, chaperone PapD; Chaperone protein Agg3D 22248 13715040 O3K_26212 Escherichia coli O104:H4 str. 2011C-3493 Chaperone protein Agg3D YP_006792568.1 21619 R 1133852 CDS YP_006792569.1 407484831 13715041 complement(22524..22727) 1 NC_018666.1 hypothetical protein 22727 13715041 O3K_26217 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006792569.1 22524 R 1133852 CDS YP_006792570.1 407484832 13715042 complement(23226..23837) 1 NC_018666.1 COG1961 Site-specific recombinases, DNA invertase Pin homologs; Resolvase 23837 13715042 O3K_26222 Escherichia coli O104:H4 str. 2011C-3493 Resolvase YP_006792570.1 23226 R 1133852 CDS YP_006792571.1 407484833 13715043 23924..24301 1 NC_018666.1 COG1974 SOS-response transcriptional repressors (RecA-mediated autopeptidases); putative UV protection protein 24301 13715043 O3K_26227 Escherichia coli O104:H4 str. 2011C-3493 putative UV protection protein YP_006792571.1 23924 D 1133852 CDS YP_006792572.1 407484834 13715044 24301..25497 1 NC_018666.1 COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair; DNA polymerase V subunit UmuC 25497 umuC 13715044 umuC Escherichia coli O104:H4 str. 2011C-3493 DNA polymerase V subunit UmuC YP_006792572.1 24301 D 1133852 CDS YP_006792573.1 407484835 13715045 complement(25577..25993) 1 NC_018666.1 hypothetical protein 25993 13715045 O3K_26237 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006792573.1 25577 R 1133852 CDS YP_006792574.1 407484836 13715046 complement(25986..26966) 1 NC_018666.1 COG0443 Molecular chaperone; Plasmid segregation protein (ParA locus) 26966 13715046 O3K_26242 Escherichia coli O104:H4 str. 2011C-3493 Plasmid segregation protein (ParA locus) YP_006792574.1 25986 R 1133852 CDS YP_006792575.1 407484837 13715047 complement(27380..27688) 1 NC_018666.1 putative chaperonin 27688 13715047 O3K_26247 Escherichia coli O104:H4 str. 2011C-3493 putative chaperonin YP_006792575.1 27380 R 1133852 CDS YP_006792576.1 407484838 13715048 complement(27775..28419) 1 NC_018666.1 COG1192 ATPases involved in chromosome partitioning; ATPase involved in chromosome partitioning 28419 13715048 O3K_26252 Escherichia coli O104:H4 str. 2011C-3493 ATPase involved in chromosome partitioning YP_006792576.1 27775 R 1133852 CDS YP_006792577.1 407484839 13715049 complement(28598..29404) 1 NC_018666.1 COG0582 Integrase; putative resolvase 29404 13715049 O3K_26257 Escherichia coli O104:H4 str. 2011C-3493 putative resolvase YP_006792577.1 28598 R 1133852 CDS YP_006792578.1 407484840 13715050 complement(29405..29710) 1 NC_018666.1 plasmid maintenance protein CcdB 29710 13715050 O3K_26262 Escherichia coli O104:H4 str. 2011C-3493 plasmid maintenance protein CcdB YP_006792578.1 29405 R 1133852 CDS YP_006792579.1 407484841 13715051 complement(29712..29930) 1 NC_018666.1 COG5302 Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid; plasmid maintenance protein CcdA 29930 13715051 O3K_26267 Escherichia coli O104:H4 str. 2011C-3493 plasmid maintenance protein CcdA YP_006792579.1 29712 R 1133852 CDS YP_006792580.1 407484842 13715052 30525..30755 1 NC_018666.1 COG4456 Virulence-associated protein and related proteins; hypothetical protein 30755 13715052 O3K_26272 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006792580.1 30525 D 1133852 CDS YP_006792581.1 407484843 13715053 30752..31180 1 NC_018666.1 COG1487 Predicted nucleic acid-binding protein, contains PIN domain; hypothetical protein 31180 13715053 O3K_26277 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006792581.1 30752 D 1133852 CDS YP_006792582.1 407484844 13715054 complement(31263..31418) 1 NC_018666.1 COG3436 Transposase and inactivated derivatives; hypothetical protein 31418 13715054 O3K_26282 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006792582.1 31263 R 1133852 CDS YP_006792583.1 407484845 13715055 32504..33481 1 NC_018666.1 putative RepFIB replication protein A 33481 13715055 O3K_26287 Escherichia coli O104:H4 str. 2011C-3493 putative RepFIB replication protein A YP_006792583.1 32504 D 1133852 CDS YP_006792584.1 407484846 13715056 complement(33760..34500) 1 NC_018666.1 COG0582 Integrase; putative resolvase (protein D) 34500 13715056 O3K_26292 Escherichia coli O104:H4 str. 2011C-3493 putative resolvase (protein D) YP_006792584.1 33760 R 1133852 CDS YP_006792585.1 407484847 13715057 complement(34869..34955) 1 NC_018666.1 hypothetical protein 34955 13715057 O3K_26297 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006792585.1 34869 R 1133852 CDS YP_006792586.1 407484848 13715058 complement(35232..35477) 1 NC_018666.1 COG3609 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain; hypothetical protein 35477 13715058 O3K_26302 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006792586.1 35232 R 1133852 CDS YP_006792587.1 407484849 13715059 complement(35483..35758) 1 NC_018666.1 COG3668 Plasmid stabilization system protein; hypothetical protein 35758 13715059 O3K_26307 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006792587.1 35483 R 1133852 CDS YP_006792588.1 407484850 13715060 complement(35758..36042) 1 NC_018666.1 hypothetical protein 36042 13715060 O3K_26312 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006792588.1 35758 R 1133852 CDS YP_006792589.1 407484851 13715061 complement(36950..37621) 1 NC_018666.1 replication protein 37621 13715061 O3K_26317 Escherichia coli O104:H4 str. 2011C-3493 replication protein YP_006792589.1 36950 R 1133852 CDS YP_006792590.1 407484852 13715062 complement(37590..37778) 1 NC_018666.1 replication protein 37778 13715062 O3K_26322 Escherichia coli O104:H4 str. 2011C-3493 replication protein YP_006792590.1 37590 R 1133852 CDS YP_006792591.1 407484853 13715063 complement(37771..37845) 1 NC_018666.1 leader peptide RepL 37845 13715063 O3K_26327 Escherichia coli O104:H4 str. 2011C-3493 leader peptide RepL YP_006792591.1 37771 R 1133852 CDS YP_006792592.1 407484854 13715064 complement(38083..38337) 1 NC_018666.1 replication protein 38337 13715064 O3K_26332 Escherichia coli O104:H4 str. 2011C-3493 replication protein YP_006792592.1 38083 R 1133852 CDS YP_006792593.1 407484855 13715065 38618..39598 1 NC_018666.1 COG3039 Transposase and inactivated derivatives, IS5 family; transposase 39598 13715065 O3K_26337 Escherichia coli O104:H4 str. 2011C-3493 transposase YP_006792593.1 38618 D 1133852 CDS YP_006792594.1 407484856 13715066 complement(40006..40176) 1 NC_018666.1 hypothetical protein 40176 13715066 O3K_26342 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006792594.1 40006 R 1133852 CDS YP_006792595.1 407484857 13715067 40326..41003 1 NC_018666.1 COG4584 Transposase and inactivated derivatives; IS66 family transposase orfA 41003 13715067 O3K_26347 Escherichia coli O104:H4 str. 2011C-3493 IS66 family transposase orfA YP_006792595.1 40326 D 1133852 CDS YP_006792596.1 407484858 13715068 41003..41350 1 NC_018666.1 COG3436 Transposase and inactivated derivatives; IS66 family element, orf2 41350 13715068 O3K_26352 Escherichia coli O104:H4 str. 2011C-3493 IS66 family element, orf2 YP_006792596.1 41003 D 1133852 CDS YP_006792597.1 407484859 13715069 41370..42941 1 NC_018666.1 COG3436 Transposase and inactivated derivatives; hypothetical protein 42941 13715069 O3K_26357 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006792597.1 41370 D 1133852 CDS YP_006792598.1 407484860 13715070 complement(42995..43180) 1 NC_018666.1 COG3436 Transposase and inactivated derivatives; putative transposase 43180 13715070 O3K_26362 Escherichia coli O104:H4 str. 2011C-3493 putative transposase YP_006792598.1 42995 R 1133852 CDS YP_006792599.1 407484861 13715071 complement(43254..43550) 1 NC_018666.1 COG3436 Transposase and inactivated derivatives; hypothetical protein 43550 13715071 O3K_26367 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006792599.1 43254 R 1133852 CDS YP_006792600.1 407484862 13715072 complement(43547..43981) 1 NC_018666.1 COG2963 Transposase and inactivated derivatives; hypothetical protein 43981 13715072 O3K_26372 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006792600.1 43547 R 1133852 CDS YP_006792601.1 407484863 13715073 complement(44210..44770) 1 NC_018666.1 conjugal transfer fertility inhibition protein FinO 44770 13715073 O3K_26377 Escherichia coli O104:H4 str. 2011C-3493 conjugal transfer fertility inhibition protein FinO YP_006792601.1 44210 R 1133852 CDS YP_006792602.1 407484864 13715074 complement(44825..45571) 1 NC_018666.1 conjugal transfer pilus acetylation protein TraX 45571 13715074 O3K_26382 Escherichia coli O104:H4 str. 2011C-3493 conjugal transfer pilus acetylation protein TraX YP_006792602.1 44825 R 1133852 CDS YP_006792603.1 407484865 13715075 complement(45591..45728) 1 NC_018666.1 conjugal transfer nickase/helicase TraI 45728 13715075 O3K_26387 Escherichia coli O104:H4 str. 2011C-3493 conjugal transfer nickase/helicase TraI YP_006792603.1 45591 R 1133852 CDS YP_006792604.1 407484866 13715076 complement(45804..49517) 1 NC_018666.1 COG0507 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member; conjugal transfer nickase/helicase TraI 49517 13715076 O3K_26392 Escherichia coli O104:H4 str. 2011C-3493 conjugal transfer nickase/helicase TraI YP_006792604.1 45804 R 1133852 CDS YP_006792605.1 407484867 13715077 complement(49522..50196) 1 NC_018666.1 COG0507 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member; conjugal transfer nickase/helicase TraI 50196 13715077 O3K_26397 Escherichia coli O104:H4 str. 2011C-3493 conjugal transfer nickase/helicase TraI YP_006792605.1 49522 R 1133852 CDS YP_006792606.1 407484868 13715078 50318..50617 1 NC_018666.1 COG3677 Transposase and inactivated derivatives; IS1 orfA 50617 13715078 O3K_26402 Escherichia coli O104:H4 str. 2011C-3493 IS1 orfA YP_006792606.1 50318 D 1133852 CDS YP_006792607.1 407484869 13715080 complement(51661..52044) 1 NC_018666.1 COG1082 Sugar phosphate isomerases/epimerases; conjugal transfer protein TraM 52044 13715080 O3K_26412 Escherichia coli O104:H4 str. 2011C-3493 conjugal transfer protein TraM YP_006792607.1 51661 R 1133852 CDS YP_006792608.1 407484870 13715081 52468..52977 1 NC_018666.1 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains); lytic transglycosylase 52977 13715081 O3K_26417 Escherichia coli O104:H4 str. 2011C-3493 lytic transglycosylase YP_006792608.1 52468 D 1133852 CDS YP_006792609.1 407484871 13715082 complement(53295..54095) 1 NC_018666.1 YubP 54095 13715082 O3K_26422 Escherichia coli O104:H4 str. 2011C-3493 YubP YP_006792609.1 53295 R 1133852 CDS YP_006792610.1 407484872 13715083 54890..55147 1 NC_018666.1 COG1961 Site-specific recombinases, DNA invertase Pin homologs; putative recombinase 55147 13715083 O3K_26427 Escherichia coli O104:H4 str. 2011C-3493 putative recombinase YP_006792610.1 54890 D 1133852 CDS YP_006792611.1 407484873 13715084 55669..59763 1 NC_018666.1 COG3468 Type V secretory pathway, adhesin AidA; protease IgA1 59763 13715084 O3K_26432 Escherichia coli O104:H4 str. 2011C-3493 protease IgA1 YP_006792611.1 55669 D 1133852 CDS YP_006792612.1 407484874 13715085 complement(60058..60243) 1 NC_018666.1 COG3436 Transposase and inactivated derivatives; hypothetical protein 60243 13715085 O3K_26437 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006792612.1 60058 R 1133852 CDS YP_006792613.1 407484875 13715086 60357..60791 1 NC_018666.1 COG2963 Transposase and inactivated derivatives; hypothetical protein 60791 13715086 O3K_26442 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006792613.1 60357 D 1133852 CDS YP_006792614.1 407484876 13715087 60788..61138 1 NC_018666.1 COG3436 Transposase and inactivated derivatives; hypothetical protein 61138 13715087 O3K_26447 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006792614.1 60788 D 1133852 CDS YP_006792615.1 407484877 13715088 61169..62668 1 NC_018666.1 COG3436 Transposase and inactivated derivatives; IS66 family protein; transposase ORF1, IS66 family protein 62668 13715088 O3K_26452 Escherichia coli O104:H4 str. 2011C-3493 transposase ORF1, IS66 family protein YP_006792615.1 61169 D 1133852 CDS YP_006792616.1 407484878 13715089 complement(62938..63978) 1 NC_018666.1 COG3547 Transposase and inactivated derivatives; transposase, IS110 family protein 63978 13715089 O3K_26457 Escherichia coli O104:H4 str. 2011C-3493 transposase, IS110 family protein YP_006792616.1 62938 R 1133852 CDS YP_006792617.1 407484879 13715090 complement(64953..66164) 1 NC_018666.1 COG0815 Apolipoprotein N-acyltransferase; AatD 66164 13715090 O3K_26462 Escherichia coli O104:H4 str. 2011C-3493 AatD YP_006792617.1 64953 R 1133852 CDS YP_006792618.1 407484880 13715091 complement(66181..66810) 1 NC_018666.1 COG1136 ABC-type antimicrobial peptide transport system, ATPase component; AatC ATB binding protein of ABC transporter 66810 13715091 O3K_26467 Escherichia coli O104:H4 str. 2011C-3493 AatC ATB binding protein of ABC transporter YP_006792618.1 66181 R 1133852 CDS YP_006792619.1 407484881 13715092 complement(66803..67441) 1 NC_018666.1 AatB 67441 13715092 O3K_26472 Escherichia coli O104:H4 str. 2011C-3493 AatB YP_006792619.1 66803 R 1133852 CDS YP_006792620.1 407484882 13715093 complement(67521..68759) 1 NC_018666.1 AatA outermembrane protein 68759 13715093 O3K_26477 Escherichia coli O104:H4 str. 2011C-3493 AatA outermembrane protein YP_006792620.1 67521 R 1133852 CDS YP_006792621.1 407484883 13715094 complement(68756..69886) 1 NC_018666.1 COG0577 ABC-type antimicrobial peptide transport system, permease component; AatP permease 69886 13715094 O3K_26482 Escherichia coli O104:H4 str. 2011C-3493 AatP permease YP_006792621.1 68756 R 1133852 CDS YP_006792622.1 407484884 13715095 70508..70600 1 NC_018666.1 ISSfl4 ORF3; transposase 70600 13715095 O3K_26492 Escherichia coli O104:H4 str. 2011C-3493 transposase YP_006792622.1 70508 D 1133852 CDS YP_006792623.1 407484885 13715096 70657..70893 1 NC_018666.1 COG2963 Transposase and inactivated derivatives; hypothetical protein 70893 13715096 O3K_26497 Escherichia coli O104:H4 str. 2011C-3493 hypothetical protein YP_006792623.1 70657 D 1133852 CDS