-- dump date 20140619_081423 -- class Genbank::CDS -- table cds_note -- id note YP_003043230.1 similar to b0001 YP_003043231.1 multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways YP_003043232.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate YP_003043233.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine YP_003043234.1 similar to b0005 YP_003043235.1 similar to b0006 YP_003043236.1 similar to b0007 YP_003043237.1 similar to b0008 YP_003043238.1 forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis YP_003043239.1 similar to b0010 YP_003043242.1 similar to b0013 YP_003043243.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_003043244.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_003043246.1 similar to b0018 YP_003043247.1 similar to b4412 YP_003043248.1 exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH YP_003043249.1 Na+/H+ antiporter regulatory protein; activates the genes nhaA and osmC YP_003043257.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase YP_003043258.1 similar to b0024 YP_003043259.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities YP_003043260.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme YP_003043261.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_003043262.1 similar to b0028 YP_003043263.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway YP_003043264.1 catalyzes the hydrolysis of both purine and pyrimidine ribonucleosides YP_003043265.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis YP_003043266.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_003043267.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity YP_003043268.1 regulator of carnitine metabolism; induces the caiTABCDE and fixABCX operons YP_003043269.1 involved in the synthesis of a cofactor required for carnitine dehydratase and carnitine racemase activities YP_003043270.1 catalyzes the dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA YP_003043271.1 similar to b0037 YP_003043272.1 catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA YP_003043273.1 catalyzes the exchange of L-carnitine for gamma-butyrobetaine in carnitine metabolism YP_003043274.1 required for anaerobic carnitine reduction, may act to transfer electrons to crotonobetaine reductase YP_003043275.1 involved in electron transfer during carnitine metabolism YP_003043276.1 FAD/NAD(P)-binding domain; possibly part of an electron transfer system required for anaerobic carnitine reduction YP_003043277.1 similar to b0044 YP_003043278.1 similar to b0045 YP_003043279.1 Required for full activity of KefC, a potassium-proton antiporter YP_003043280.1 transport system that facilitates potassium-efflux YP_003043281.1 catalyzes the reduction of dihydrofolate to tetrahydrofolate YP_003043282.1 hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP YP_003043283.1 protein associated with Co2+ and Mg2+ efflux YP_003043284.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_003043285.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate) YP_003043286.1 Chaperone involved in the folding of extracytoplasmic proteins, especially OmpA, OmpF and LamB YP_003043287.1 determines N-hexane tolerance and is involved in outer membrane permeability YP_003043288.1 functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system YP_003043289.1 catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs YP_003043290.1 transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA YP_003043291.1 Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95#C YP_003043292.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source YP_003043293.1 catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism YP_003043294.1 catalyzes the phosphorylation of ribulose to ribulose 5-phosphate YP_003043295.1 positive and negative regulator; regulates the araBAD and araFGH operons and other genes involved in the transport and catabolism of L-arabinose YP_003043296.1 similar to b0065 YP_003043297.1 with TbpA and ThiP is part of the thiamine and TPP transport system YP_003043298.1 permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine YP_003043299.1 part of the thiamine and TPP transport system tbpA-thiPQ YP_003043300.1 activates sgrS under glucose-phosphate stress conditions YP_003043301.1 similar to b0070 YP_003043302.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D YP_003043303.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate YP_003043304.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis YP_003043305.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis YP_003043306.1 involved in attenuation control of the leuABCD operon in leucine biosynthesis YP_003043307.1 activator for leuABCD operon; member of LysR family of transcriptional activators YP_003043308.1 catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive YP_003043309.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit YP_003043310.1 binds D-fructose as an inducer; involved in regulation of operons for central pathways of carbon metabolism YP_003043311.1 MraZ; UPF0040; crystal structure shows similarity to AbrB YP_003043312.1 similar to b0082 YP_003043313.1 membrane bound cell division protein at septum containing leucine zipper motif YP_003043314.1 similar to b0084 YP_003043315.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate YP_003043316.1 similar to b0086 YP_003043317.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_003043318.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation YP_003043319.1 integral membrane protein involved in stabilizing FstZ ring during cell division YP_003043320.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_003043321.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_003043322.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_003043323.1 involved in growth of wall at septum; involved in septum formation YP_003043324.1 ATP-binding involved in recruitment of FtsK to Z ring; essential cell division protein; colocalizes with FtsZ through direct interaction to the septal ring structure; structurally similar to eukaryotic actin; binds directly to the cell membrane YP_003043325.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_003043326.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis YP_003043327.1 secM translational pause allows for the initiation of secA translation YP_003043328.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins YP_003043329.1 similar to b0099 YP_003043330.1 similar to b0101 YP_003043331.1 similar to b0102 YP_003043332.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis YP_003043333.1 catalyzes the NADPH-dependent deamination of GMP to inosine monophosphate YP_003043334.1 similar to b0106 YP_003043335.1 similar to b0107 YP_003043336.1 similar to b0108 YP_003043337.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide YP_003043338.1 similar to b0110 YP_003043339.1 involved in regulation of beta-lactamase; putative signaling protein YP_003043340.1 similar to b0112 YP_003043341.1 activates lctPRD operon; autoregulates itself through repression of pdhR-aceEF-lpdA operon; regulates pyruvate dehydrogenase complex YP_003043342.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC YP_003043343.1 E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains YP_003043344.1 E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide YP_003043345.1 similar to b0117 YP_003043346.1 catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate YP_003043347.1 similar to b0119 YP_003043348.1 S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine YP_003043349.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine YP_003043350.1 similar to b0122 YP_003043351.1 laccase; copper-stimulated phenoloxidase and ferroxidase which may be involved in copper detoxification YP_003043352.1 similar to b0124 YP_003043353.1 similar to b0125 YP_003043354.1 catalyzes the interconversion of bicarbonate and carbon dioxide YP_003043355.1 similar to b0127 YP_003043356.1 similar to b0128 YP_003043357.1 similar to b0129 YP_003043358.1 similar to b0130 YP_003043359.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5) YP_003043360.1 similar to b0132 YP_003043361.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine YP_003043362.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate YP_003043363.1 similar to b0135 YP_003043364.1 similar to b0136 YP_003043365.1 similar to b0137 YP_003043366.1 similar to b0138 YP_003043367.1 similar to the fimbrial usher protein PapC YP_003043368.1 similar to b0140 YP_003043369.1 similar to b0141 YP_003043370.1 catalyzes the formation of 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine and ATP YP_003043371.1 Polymerase that creates the 3' poly(A) tail found in some mRNA's YP_003043372.1 this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu YP_003043373.1 similar to b0145 YP_003043374.1 Regulatory factor involved in maltose metabolism YP_003043375.1 similar to b0147 YP_003043376.1 similar in sequence to the ATP-dependent RNA helicase HrpA YP_003043377.1 bifunctional periplasmic enzyme; contains transglycosylase and transpeptidase activity; major enzyme for peptidoglycan biosynthesis in Escherichia coli; transmembrane protein; forms dimers; three variants, one of which may be a degradation product, while the other appears to result from an alternative initiation site, are found within the cell YP_003043378.1 involved with the transport of ferrichrome across the outer membrane; binds the ferrichrome-iron ligand and interacts with the TonB protein YP_003043379.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter YP_003043380.1 Part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; binds to all hydroxamate siderophores YP_003043381.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome YP_003043382.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway YP_003043383.1 Acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation YP_003043384.1 essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors YP_003043385.1 similar to b0157 YP_003043386.1 solute binding component of the vitamin B12 transport system BtuCDF YP_003043387.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine YP_003043388.1 forms a homotetramer; requires magnesium for activity; catalyzes the hydrolysis of dGTP to form deoxyguanosine and triphosphate YP_003043389.1 protease Do; required at high temperature; degrades damaged proteins YP_003043390.1 regulates the expression of the operons for the enzymes involved in galactarate, glucarate and glycerate utilization YP_003043391.1 similar to b0163 YP_003043392.1 similar to b0164 YP_003043393.1 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway YP_003043394.1 catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein YP_003043395.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn YP_003043396.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_003043397.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_003043398.1 Catalyzes the phosphorylation of UMP to UDP YP_003043399.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_003043400.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate YP_003043401.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate YP_003043402.1 catalyzes the synthesis of CDP-diglyceride from CTP and phosphatidate YP_003043403.1 catalyzes the cleavage of RseA which activates the sigmaE-mediated stress response YP_003043404.1 part of a complex with YfgL, YfiO, and NlpB involved in outer membrane protein biosynthesis; involved in the assembly of outer membrane proteins YP_003043405.1 similar to b0178 YP_003043406.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis YP_003043407.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP YP_003043408.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis YP_003043409.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM YP_003043410.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids YP_003043411.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase YP_003043412.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein YP_003043413.1 similar to b0186 YP_003043414.1 similar to b0187 YP_003043415.1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU; ATP-dependent; responsible for modifying the wobble-base of the CAU anticodon of tRNAIle such that it exhibits proper recognition of the AUA codon rather than the AUG codon and is in turn properly recognized by isoleucyl-tRNA synthetase YP_003043416.1 Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination YP_003043417.1 similar to b4406 YP_003043418.1 similar to b0190 YP_003043419.1 similar to b0191 YP_003043420.1 similar to b0192 YP_003043421.1 similar to b0193 YP_003043422.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_003043423.1 similar to b0195 YP_003043424.1 similar to b0196 YP_003043425.1 similar to b0197 YP_003043426.1 part of the MetNIQ methionine uptake system YP_003043427.1 part of the metNIQ transport system for methionine YP_003043428.1 Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate YP_003043429.1 catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid YP_003043430.1 similar to b0208 YP_003043431.1 similar to b0209 YP_003043432.1 similar to b0210 YP_003043433.1 catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; may play a role in recycling muropeptides during cell division and/or cell elongation; in Helicobacter pylori MltD is a endolytic transglycosylase involved mainly in the rearrangement of the peptidoglycan layer of the bacterial cell wall YP_003043434.1 catalyzes the hydrolysis of S-D-lactoylglutathione to D-lactic acid and reduced glutathione; plays an important role in cellular detoxification using glutathione YP_003043435.1 similar to b0213 YP_003043436.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids YP_003043437.1 3'-5' exonuclease of DNA polymerase III YP_003043438.1 similar to b0217 YP_003043442.1 similar to b3484 YP_003043443.1 similar to b0219 YP_003043444.1 inactivates vertebrate C-type lysozyme YP_003043445.1 functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA YP_003043446.1 catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate YP_003043447.1 similar to b0223 YP_003043448.1 similar to b0224 YP_003043449.1 similar to b0225 YP_003043450.1 similar to b0226 YP_003043451.1 similar to b0227 YP_003043452.1 similar to b0228 YP_003043453.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function YP_003043454.1 similar to b0232 YP_003043455.1 YafO overproduction induces toxicity; it is believed to be the toxin of a toxin-antitoxin pair; unknown function YP_003043456.1 similar to b0234 YP_003043457.1 similar to b0235 YP_003043458.1 similar to release factor 1 and 2 YP_003043459.1 similar to b0237 YP_003043460.1 catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively YP_003043461.1 forms a 1:1 complex with the unphosphorylated from of enzyme IIAGlc; FrsA may promote fermentation YP_003043462.1 involved in the expression of csgBA which is involved in curli formation; interacts with sigmaS YP_003043465.1 similar to b0241 YP_003043466.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis YP_003043467.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway YP_003043468.1 similar to b0282 YP_003043469.1 similar to b0283 YP_003043470.1 similar to b0284 YP_003043471.1 similar to b0285 YP_003043472.1 similar to b0286 YP_003043473.1 similar to b0287 YP_003043474.1 similar to b0288 YP_003043475.1 similar to b0289 YP_003043476.1 similar to b0290 YP_003043477.1 similar to b0291 YP_003043478.1 similar to b0292 YP_003043479.1 similar to b0293 YP_003043480.1 similar to b0294 YP_003043481.1 similar to b0295 YP_003043482.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_003043483.1 similar to b0297 YP_003043484.1 similar to b0300 YP_003043485.1 similar to b0301 YP_003043486.1 similar to b0303 YP_003043487.1 Involved in disulfide oxidoreductase activity and electron transport YP_003043488.1 similar to b0305 YP_003043489.1 similar to b0306 YP_003043490.1 similar to b0307 YP_003043491.1 similar to b0308 YP_003043492.1 similar to b0309; deleted entry from K-12 MG1655 YP_003043493.1 similar to b0310 YP_003043494.1 catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine YP_003043495.1 catalyzes the formation of betaine from betaine aldehyde YP_003043496.1 HTH-type; bet1; Repressor involved in choline regulation of the bet genes YP_003043497.1 proton-motive-force-driven choline transporter YP_003043498.1 similar to b0315 YP_003043499.1 similar to b0316 YP_003043500.1 similar to b0317 YP_003043501.1 similar to b0318 YP_003043502.1 similar to b0319 YP_003043503.1 similar to b0320 YP_003043504.1 similar to b0321 YP_003043505.1 similar to b0323 YP_003043506.1 metallo-dependent hydrolase superfamily; deaminase with metallo-dependent hydrolase domain YP_003043507.1 similar to b0325 YP_003043508.1 similar to b0326 YP_003043509.1 similar to b0327 YP_003043510.1 similar to b0328 YP_003043511.1 similar to b0329 YP_003043512.1 similar to b0330 YP_003043513.1 catalyzes the formation of pyruvate and succinate from 2-methylisocitrate YP_003043514.1 catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity YP_003043515.1 functions in propionate metabolism; involved in isomerization of (2S,3S)-methylcitrate to (2R,3S)-methylisocitrate; also encodes minor aconitase or dehydratase activity; aconitase C YP_003043516.1 catalyzes the formation of propionyl-CoA using propionate as a substrate; PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A; not expressed in Escherichia coli when grown on propionate/minimal media; ATP-dependent YP_003043517.1 similar to b0336 YP_003043518.1 Catalyzes the deamination of cytosine to uracil and ammonia YP_003043519.1 controls the expression of the cynTSX operon involved in degrading and using cyanate as a sole nitrogen source YP_003043520.1 similar to b0339 YP_003043521.1 catalyzes the reaction of cyanate and bicarbonate to produce ammonia and carbon dioxide YP_003043522.1 MFS transporter family member induced in the presence of cyanate as part of a 3 gene operon; not essential YP_003043523.1 transfers acetyl group from acetyl-CoA to the 6-hydroxyl of galactopyranosides; exact physiological role is unknown YP_003043524.1 lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments YP_003043525.1 forms a homotetramer; hydrolyzes lactose disaccharide to galactose and glucose; converts lactose to allolactose which is the natural inducer of the lac operon YP_003043526.1 transcriptional repressor of lac operon; forms a homotetramer as a dimer of dimers; binds specific sites in lac operon resulting in DNA looping between the operators; binds allolactose as inducer YP_003043527.1 activator of 3-phenylpropionic acid catabolism YP_003043528.1 catalyzes the formation of 3-(2,3-dihydroxyphenyl)propionate from 3-(3-hydroxyphenyl)propionate YP_003043529.1 catalyzes the cleavage of 3-(2,3-dihydroxyphenyl) propionate into 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate; part of the 3-phenylpropionic acid degradation pathway; member of the protocatechuate 4,5-dioxygenase family YP_003043530.1 similar to b0349 YP_003043531.1 catalyzes the formation of 2-keto-4-hydroxypentanoic acid from 2-hydroxypentadienoic acid YP_003043532.1 catalyzes the formation of acetyl-CoA from acetalaldehyde YP_003043533.1 catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate YP_003043534.1 similar to b0353 YP_003043535.1 similar to b0354 YP_003043536.1 similar to b0355 YP_003043537.1 similar to b0356 YP_003043538.1 formaldehyde-induced negative regulator of the frmRAB operon YP_003043539.1 similar to b0358 YP_003043542.1 with TauB and TauC is responsible for taurine uptake. YP_003043543.1 Part of the ABC transporter complex tauABC involved in taurine import YP_003043544.1 similar to b0367 YP_003043545.1 catalyzes the conversion of taurine (2-aminoethanesulfonate) to sulfite and aminoacetaldehyde concurrently with the conversion of alpha-ketoglutarate to succinate and carbon dioxide; non-heme iron oxidase; allows the use of taurine as an alternative sulfur source; forms homodimers YP_003043546.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_003043547.1 similar to b0370 YP_003043548.1 similar to b0371-b0374 YP_003043549.1 similar to b0375 YP_003043550.1 this protein has no known enzymatic function YP_003043551.1 in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA, TonB, and ExbB/D in this capacity; in Sinorhizobium meliloti, BacA is essential and required for symbiosis; defects appear to affect the cell envelope YP_003043552.1 similar to b0378 YP_003043553.1 similar to b0379 YP_003043554.1 similar to b0380 YP_003043555.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_003043556.1 similar to b0382 YP_003043557.1 similar to b0383 YP_003043558.1 similar to b0384 YP_003043559.1 catalyzes the conversion of 2 GTP into c-di-GMP; adrA overexpression induces cellulose biosynthesis, cell adherence to abiotic surfaces and swimming and swarming motility; AdrA acts post-transcriptionally on the bcsABZC operon activating cellulose biosynthesis YP_003043560.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate YP_003043561.1 similar to b0387 YP_003043562.1 type II enzyme similar to type I but differentially regulated and with a lower Km; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis YP_003043563.1 similar to b0389 YP_003043564.1 similar to b0390 YP_003043565.1 similar to b0391 YP_003043566.1 similar to b0392 YP_003043569.1 Required for efficient pilin antigenic variation YP_003043570.1 catalyzes phosphorylation of fructose; cytosolic enzyme YP_003043571.1 member of the major facilitator superfamily (MFS) of transporters; unknown function; may be associated with transport or processing of arabinose polymers YP_003043572.1 with SbcD cleaves DNA hairpin structures; also has 5' single-strand endonuclease activity YP_003043573.1 with SbcC cleaves DNA hairpin structure, also has 5' single-strand endonuclease activity YP_003043574.1 two component response regulator for the phosphate regulon; PhoR phosphorylates PhoB YP_003043575.1 membrane-associated histidine protein kinase that phosphorylates phoB in response to environmental signals as part of the two-component phosphate regulatory system phoR/phoB YP_003043576.1 similar to b0401 YP_003043577.1 cryptic permease that may be involved in the transport of proline across the inner membrane; in Salmonella typhimurium, the proY gene is silent unless overexpressed on a multicopy plasmid or activated by a proZ mutation YP_003043578.1 similar to b0403 YP_003043579.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step YP_003043580.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr) YP_003043581.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex YP_003043582.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane YP_003043583.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF YP_003043584.1 similar to b0410 YP_003043585.1 similar to b0411 YP_003043586.1 similar to b0412 YP_003043587.1 similar to b0413 YP_003043588.1 riboflavin biosynthesis protein which catalyzes the deamination and reduction steps in the riboflavin biosynthesis pathway; catalyzes the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 5-amino-6-(5-phosphoribitylamino)uracil YP_003043589.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not YP_003043590.1 Regulates rRNA biosynthesis by transcriptional antitermination YP_003043591.1 catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP YP_003043592.1 hydrolyzes phosphatidylglycerophosphate to produce phosphatidylglycerol and phosphate YP_003043593.1 similar to b0419 YP_003043594.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate YP_003043595.1 similar to b0421 YP_003043596.1 catalyzes the bidirectional exonucleolytic cleavage of DNA YP_003043597.1 Required for the synthesis of the thiazole moiety YP_003043598.1 similar to b0424 YP_003043599.1 ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis YP_003043600.1 putative nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription YP_003043601.1 similar to b0427 YP_003043605.1 converts protoheme IX and farnesyl diphosphate to heme O YP_003043606.1 similar to b0429 YP_003043607.1 similar to b0430 YP_003043608.1 similar to b0431 YP_003043609.1 similar to b0432 YP_003043610.1 in Escherichia coli this protein is a permease involved in peptidoglycan recycling; member of major facilitator superfamily; MFS; inner membrane protein YP_003043611.1 similar to b0434 YP_003043612.1 positive transcriptional regulator of morphogenetic pathway; controlling several genes involved in oxidative stress, acid stress, heat shock, osmotic shock, and carbon-starvation stress YP_003043613.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer YP_003043614.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_003043615.1 binds and unfolds substrates as part of the ClpXP protease YP_003043617.1 similar to b0439 YP_003043618.1 histone-like DNA-binding protein YP_003043619.1 similar to b0441 YP_003043620.1 similar to b0442 YP_003043621.1 similar to b0443 YP_003043622.1 YbaX; catalyzes the transformation of GTP to 7-cyano-7-deazaguanine (preQ0), as one of the early reactions of quenosine biosynthesis; quenosine is a modified nucleoside that occurs at the wobble position of GUN anticodons in tRNAs for Asn, Asp, Tyr, and His YP_003043623.1 similar to b0445 YP_003043624.1 similar to b0446 YP_003043625.1 similar to b0447 YP_003043626.1 similar to b0448 YP_003043627.1 similar to b0449 YP_003043628.1 indirectly regulates nitrogen metabolism; at high nitrogen levels P-II 2 prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II 2 is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; functionally it is equivalent to protein P-II (GlnB), but itsexpression is driven by the presence of uridylyltransferase, nitrogen regulator I, and the absence of ammonia. YP_003043629.1 similar to b0451 YP_003043630.1 similar to b0452 YP_003043631.1 similar to b0453 YP_003043632.1 similar to b0454 YP_003043633.1 similar to b0456 YP_003043634.1 similar to b0457 YP_003043635.1 similar to b0458 YP_003043636.1 similar to b0459 YP_003043637.1 with Hns involved in transcriptional regulation of hemolysin; non-specific DNA-binding protein which affects the production of multiple proteins YP_003043638.1 similar to b0461 YP_003043639.1 similar to b0462 YP_003043640.1 similar to b0463 YP_003043641.1 regulates the acrAB operon which is involved in susceptibility to dephalothin and cephaloridine YP_003043642.1 small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS YP_003043643.1 similar to b0466 YP_003043644.1 PriC; protein involved in DNA replication; part of the primosome, a protein complex required to restart stalled replication forks; binds the complex formed by PriA, PriB and DNA; PriC-dependent primosome requires a gap to restart DNA replication; stimulates Rep activity at stalled forks YP_003043645.1 similar to b0468 YP_003043646.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis YP_003043647.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA YP_003043648.1 similar to b0471 YP_003043649.1 involved in a recombinational process of DNA repair, independent of the recBC complex YP_003043650.1 molecular chaperone YP_003043651.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP YP_003043652.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic YP_003043653.1 similar to b0476 YP_003043654.1 similar to b0477 YP_003043655.1 YbaL; member of the CPA-2 family of antiporters; uncharacterized protein YP_003043656.1 similar to b0479 YP_003043657.1 catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides YP_003043658.1 similar to b0481 YP_003043659.1 similar to b0482 YP_003043660.1 similar to b0483 YP_003043661.1 similar to b0484 YP_003043662.1 catalyzes the formation of glutamate from glutamine YP_003043663.1 similar to b0486 YP_003043664.1 DNA-binding transcriptional activator of copper-responsive regulon genes YP_003043665.1 similar to b0488 YP_003043666.1 similar to b0489 YP_003043667.1 similar to b0490 YP_003043668.1 similar to b0491 YP_003043669.1 similar to b0492 YP_003043670.1 similar to b0493 YP_003043671.1 similar to b0494 YP_003043672.1 similar to b0495 YP_003043673.1 similar to b0496 YP_003043674.1 similar to b0497 YP_003043675.1 similar to b0498 YP_003043676.1 similar to b0499 YP_003043677.1 similar to b0500 YP_003043678.1 similar to b0502 YP_003043679.1 catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA YP_003043680.1 activator of the allDC-ylbA operon involved in allantoin utilization YP_003043681.1 catalyzes the formation of glyoxylate from (S)-ureidoglycolate YP_003043682.1 regulates operons involved in the utilization of allantoin YP_003043683.1 catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate YP_003043684.1 similar to b0508 YP_003043685.1 similar to b0509 YP_003043686.1 similar to b0510 YP_003043687.1 similar to b0511 YP_003043688.1 Plays a crucial role on both purine and pyrimidine metabolism YP_003043689.1 similar to b0513 YP_003043690.1 similar to b0514 YP_003043691.1 similar to b0515 YP_003043692.1 allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide YP_003043693.1 similar to b0517 YP_003043694.1 multicopy suppressor of dominant negative ftsH mutations YP_003043695.1 similar to b4507-b0519(b4582); pseudo in K-12 MG1655 (interrupted by frameshift) YP_003043696.1 similar to b0520 YP_003043697.1 similar to b0521 YP_003043698.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway YP_003043699.1 similar to b0523 YP_003043700.1 catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine YP_003043701.1 similar to b0525 YP_003043702.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_003043703.1 similar to b0527 YP_003043704.1 similar to b0528 YP_003043705.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate YP_003043706.1 similar to b0530 YP_003043707.1 similar to b0531 YP_003043708.1 similar to b0532 YP_003043709.1 similar to b0533 YP_003043710.1 similar to b0534 YP_003043711.1 activates the production of the major fimbrae protein FimA YP_003043712.1 similar to b0537 YP_003043717.1 similar to b0542 YP_003043718.1 member of the small MDR (multidrug resistance) family of transporters; in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin; proton-dependent secondary transporter which exchanges protons for compound translocation YP_003043719.1 similar to b0544 YP_003043720.1 DLP12 prophage; similar to PEBP/RK1P protein family in eukaryotes that inhibits MEK phosphorylation by Raf-1; crystal structure suggests similar properties but exact function is unknown YP_003043721.1 similar to b0546 YP_003043722.1 DLP12 prophage YP_003043723.1 DLP12 prophage; conserved protein similar to phage 82 and lambda proteins YP_003043724.1 similar to b0549 YP_003043725.1 DLP12 prophage; Holliday junction resolvase YP_003043726.1 similar to b4509 YP_003043727.1 similar to b0551 YP_003043730.1 similar to b0554 YP_003043731.1 similar to b0555 YP_003043732.1 similar to b0556 YP_003043733.1 similar to b0557 YP_003043735.1 similar to b0560 YP_003043742.1 similar to b0564 YP_003043743.1 outer membrane protease; involved in virulence in many organisms; OmpT; IcsP; SopA; Pla; PgtE; omptin; in Escherichia coli OmpT can degrade antimicrobial peptides; in Yersinia Pla activates plasminogen during infection; in Shigella flexneria SopA cleaves the autotransporter IcsA YP_003043744.1 similar to b0566 YP_003043745.1 similar to b0567 YP_003043746.1 similar to b0568 YP_003043748.1 similar to b3484 YP_003043754.1 similar to b0570 YP_003043755.1 response regulator in two-component regulatory system with CusS; regulates the copper efflux system YP_003043756.1 with CusA, CusB and CusF is part of a cation efflux system that mediates resistance to copper and silver YP_003043757.1 similar to b0573 YP_003043758.1 with CusA, CusC and CusF is part of a cation efflux system that mediates resistance to copper and silver YP_003043759.1 similar to b0575 YP_003043760.1 similar to b0576 YP_003043761.1 similar to b0577 YP_003043762.1 catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive YP_003043763.1 similar to b0579 YP_003043764.1 similar to b0580 YP_003043765.1 ATP-dependent; carboxylate-amine ligase with weak glutamate--cysteine ligase activity YP_003043769.1 similar to b4415 YP_003043771.1 similar to b0583 YP_003043772.1 Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space YP_003043773.1 similar to b0585 YP_003043774.1 similar to b4511 YP_003043775.1 with EntB, EntD, and EntE forms the multienzyme complex enterobactin synthase; EntF is the serine activating enzyme which catalyzes the formation of the amide and ester bonds of the cyclic enterobactin YP_003043776.1 part of the ferric enterobactin transport system; necessary for enetrobactin uptake YP_003043777.1 with FepBDE is involved in the transport of ferric enterobactin YP_003043778.1 with FepBCD is involved in the transport of ferric enterobactin YP_003043779.1 with FepBCG is involved in the transport of ferric enterobactin YP_003043780.1 protein p43; inner membrane protein that exports enterobactin to the periplasmic space; member of the major facilitator superfamily (MFS) of transporters YP_003043781.1 with FepCDG is involved in the transport of ferric enterobactin YP_003043782.1 similar to b0593 YP_003043783.1 bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate YP_003043784.1 similar to b0595 YP_003043785.1 catalyzes the formation of 2,3-dihydroxybenzoate from 2,3-dihydro-2,3-dihydroxybenzoate; involved in the biosynthesis of siderophores, enterobactin, bacillibactin or vibriobactin YP_003043786.1 similar to b0597 YP_003043787.1 similar to b4512 YP_003043788.1 member of the iron-containing alcohol dehydrogenase family; unknown function YP_003043789.1 catalyzes the transfer of an amino moiety YP_003043790.1 similar to b0601 YP_003043791.1 similar to b0602 YP_003043794.1 Involved in disulfide bond formation YP_003043795.1 with AhpF catalyzes the conversion of alkyl hydroperoxides to their corresponding alcohols; AhpC reduced the hydroperoxide substrate YP_003043796.1 similar to b0606 YP_003043797.1 similar to b0607 YP_003043798.1 similar to b0608 YP_003043799.1 Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation YP_003043800.1 similar to b0611 YP_003043801.1 similar to b0612 YP_003043802.1 catalyzes the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA from ATP and 3-dephospho-CoA YP_003043803.1 2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase; holo-citrate lyase synthase; CitG forms the prosthetic group precursor 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA which is then transferred to apo-ACP by CitX to produce holo-ACP and pyrophosphate YP_003043804.1 similar to b0615 YP_003043805.1 similar to b0616 YP_003043806.1 acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate YP_003043807.1 similar to b0618 YP_003043810.1 similar to b0619 YP_003043811.1 regulates the expression of citAB in citrate fermentation YP_003043812.1 responsible for the transport of C4-dicarboxylates during anaerobic growth YP_003043813.1 catalyzes the transfer of palmitate to lipid A YP_003043814.1 member of the CspA family; constitutively expressed RNA/ssDNA-binding protein; functions in helping cells adapt to low temperature; aids nucleic acid melting; participates in gene regulation; can act as a transcription antiterminator YP_003043815.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling YP_003043816.1 similar to b0625-b0626 YP_003043817.1 TatE; similar to TatA and found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes YP_003043818.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group YP_003043819.1 similar to b0629 YP_003043820.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein YP_003043821.1 similar to b0631 YP_003043822.1 penicillin-binding protein 5; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors YP_003043823.1 similar to b0633 YP_003043824.1 similar to b0634 YP_003043825.1 similar to b0635 YP_003043826.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA YP_003043827.1 similar to b0637 YP_003043828.1 similar to b0638 YP_003043829.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria YP_003043830.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA YP_003043831.1 rare lipoprotein B; involved in the assembly of LPS in the outer membrane YP_003043832.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_003043833.1 similar to b0643 YP_003043834.1 similar to b0645 YP_003043835.1 similar to b0649 YP_003043836.1 similar to b0650 YP_003043837.1 Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively; pyrimidine-specific YP_003043840.1 similar to b0653 YP_003043841.1 similar to b0654 YP_003043842.1 similar to b0655 YP_003043844.1 Transfers the fatty acyl group on membrane lipoproteins YP_003043845.1 similar to b0658 YP_003043846.1 similar to b0659 YP_003043847.1 similar to b0660 YP_003043848.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) YP_003043849.1 catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol; functions in the biosynthesis of ubiquinone or coenzyme Q YP_003043850.1 functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP YP_003043851.1 similar to b0675 YP_003043852.1 similar to b0676 YP_003043853.1 catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate YP_003043854.1 catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate YP_003043855.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_003043856.1 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_003043857.1 similar to b0681 YP_003043858.1 similar to b0682 YP_003043859.1 negatively regulates a number of operons that encode enzymes involved in iron transport; activated by manganese; forms a homodimer YP_003043860.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_003043861.1 similar to b0685 YP_003043862.1 similar to b0686 YP_003043863.1 negative modulator of the initiation of chromosome replication YP_003043864.1 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate YP_003043865.1 similar to b0689 YP_003043866.1 similar to b0690-b0691 YP_003043867.1 catalyzes the uptake of putrescine via a proton symport mechanism, as well as the efflux of putrescine by a putrescine/ornithine antiport system YP_003043868.1 similar to b0693 YP_003043870.1 response regulator in two-component regulatory system with KdpD; regulates the kdp operon involved in potassium transport YP_003043871.1 sensory histidine kinase in two-component regulatory system with KdpE; signal sensing protein YP_003043872.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex YP_003043873.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions YP_003043874.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions YP_003043875.1 one of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions YP_003043876.1 similar to b0699 YP_003043877.1 similar to b0700 YP_003043878.1 similar to b0702 YP_003043879.1 similar to b0703 YP_003043880.1 similar to b0704 YP_003043884.1 similar to b0706 YP_003043885.1 similar to b0707 YP_003043886.1 UV-induced DNA repair; converts cyclobutane-type pyrimidine dimers created during exposure to UV ratiation to monomers; light dependent YP_003043887.1 similar to b0709 YP_003043888.1 similar to b0710 YP_003043889.1 similar to b0711 YP_003043890.1 similar to b0712 YP_003043891.1 similar to b0713 YP_003043892.1 5-formyluracil/5-hydroxymethyluracil DNA glycosylase; involved in base excision repair of DNA damaged by oxidation or by mutagenic agents; acts as DNA glycosylase that recognizes and removes damaged bases with a preference for oxidized pyrimidines; has apurinic/apyrimidinic lyase activity YP_003043893.1 similar to b0715 YP_003043894.1 similar to b0716 YP_003043895.1 similar to b0717 YP_003043896.1 similar to b0718 YP_003043897.1 similar to b0719 YP_003043898.1 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH YP_003043899.1 similar to b0721 YP_003043900.1 similar to b0722 YP_003043901.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol YP_003043902.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase YP_003043903.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide YP_003043904.1 component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA YP_003043905.1 catalyzes the interconversion of succinyl-CoA and succinate YP_003043906.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle YP_003043907.1 regulates the succiny-lCoA synthetase operon YP_003043908.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake YP_003043909.1 similar to b0732 YP_003043910.1 similar to b0733 YP_003043911.1 similar to b0734 YP_003043912.1 similar to b4515 YP_003043913.1 similar to b0735 YP_003043914.1 catalyzes the hydrolysis of short chain aliphatic acyl-CoA thioesters; physiological role remains unknown; involved in phospholipid metabolism; part of the Tol/Pal system of proteins that are critical for maintaining the integrity of the cell envelope components YP_003043915.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins YP_003043916.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins YP_003043917.1 inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins YP_003043918.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA YP_003043919.1 similar to b0741 YP_003043920.1 periplasmic protein that interacts with TolA; the tol-pal system is probably involved in maintaining cell envelope integrity YP_003043921.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate YP_003043922.1 similar to b0751 YP_003043923.1 involved in zinc efflux across the cytoplasmic membrane YP_003043924.1 similar to b0753 YP_003043925.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive YP_003043926.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate YP_003043927.1 catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose YP_003043928.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism YP_003043929.1 catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P YP_003043930.1 similar to b0759 YP_003043931.1 contains 2 ATP-binding cassettes; involved in the transport of molybdenum YP_003043932.1 represses the modABCD operon and activates the moaABCD and napFDAGHBC operons YP_003043933.1 similar to b0762 YP_003043934.1 with ModCB is involved in the high-affinity transport of molybdate YP_003043935.1 part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE YP_003043936.1 Part of the ABC transporter complex modABC involved in molybdenum import YP_003043937.1 YbhA; catalyzes the dephosphorylation of pyridoxal phosphate, fructose 1,6-bisphosphate, erythrose 4-phosphate and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; phosphotransferase activity observed when using monophosphates as phosphate donor; member of the haloacid dehalogenase-like hydrolases superfamily YP_003043938.1 catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate YP_003043939.1 similar to b0768 YP_003043940.1 similar to b0769 YP_003043941.1 similar to b0770 YP_003043942.1 similar to b0771 YP_003043943.1 outer membrane lipoprotein that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; YbhC localizes to the cellular poles; member of pectinesterase family YP_003043958.1 YbhB; similar to rat and human kinase inhibitory proteins YP_003043959.1 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate YP_003043960.1 similar to b0775 YP_003043961.1 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine YP_003043962.1 putative methyltransferase; acyl carrier protein involved in an unidentified step in the synthesis of pimeloyl-CoA, a biotin precursor; member of the bio operon (bioABFCD); in Escherichia coli, bioC-null mutants require biotin for growth YP_003043963.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium YP_003043964.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_003043965.1 similar to b0780 YP_003043966.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z YP_003043967.1 similar to b0782 YP_003043968.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis YP_003043969.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin YP_003043970.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin YP_003043971.1 similar to b0786 YP_003043972.1 similar to b0787 YP_003043973.1 similar to b0788 YP_003043974.1 similar to b0789 YP_003043975.1 similar to b0790 YP_003043976.1 similar to b0791 YP_003043977.1 similar to b0792 YP_003043978.1 similar to b0793 YP_003043979.1 similar to b0794 YP_003043980.1 similar to b0795 YP_003043981.1 similar to b0796 YP_003043982.1 this helicase is not essential cell growth YP_003043983.1 similar to b0798 YP_003043984.1 helicase involved in DNA repair and perhaps also replication YP_003043985.1 similar to b0800 YP_003043986.1 similar to b0801 YP_003043987.1 similar to b0802 YP_003043988.1 similar to b0803 YP_003043989.1 similar to b0804 YP_003043990.1 Fiu; YbiL; porin involved in the uptake of iron complexed with catecholate siderophores (e.g. dihydroxybenzoylserine, dihydroxybenzoate) and beta lactam agents; Fiu interacts with TonB which provides the energy required for transport across the outer membrane; acts as a receptor for iron-siderophores and microcins E492, M, and H47; outer membrane protein YP_003043991.1 similar to b0806 YP_003043992.1 similar to b0807 YP_003043993.1 similar to b0808 YP_003043994.1 similar to ATP-binding component of ABC transporters YP_003043995.1 similar to permease component of ABC transporters; mutations impair ability of Escherichia coli to transport and utilize glutamine YP_003043996.1 similar to periplasmic-binding component of ABC transporters YP_003043997.1 DNA protection protein during starvation conditions; binds DNA in a non-sequence-specific manner and is abundant during stationary phase; forms a DNA-protein crystal that protects DNA from damage; required for normal starvation response and long-term stationary viability; forms a homododecameric complex and sequesters iron which provides protection against oxidative damage YP_003043998.1 similar to b0813 YP_003043999.1 OmpX; involved in cell adhesion; forms an eight-stranded antiparallel beta-barrel that protrudes from the cell surface; mutations in the gene increase cell-surface contact in fimbriated strains but decrease contact in nonfimbriated strains YP_003044000.1 similar to b0815 YP_003044001.1 similar to b0816 YP_003044002.1 Transcriptional regulator that represses the manganese transporter MntH when manganese is present YP_003044003.1 similar to b0818 YP_003044004.1 similar to b0819 YP_003044005.1 similar to b0820 YP_003044006.1 similar to b0821 YP_003044007.1 similar to b0822 YP_003044008.1 similar to b0823 YP_003044009.1 similar to b0824 YP_003044010.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies YP_003044011.1 ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase YP_003044012.1 is involved in the formation of active molybdenum cofactor and the chelation of molybdenum YP_003044013.1 similar to b0828 YP_003044014.1 with GsiBCD is involved in glutathione import; GsiA contains 2 ATP-binding domains YP_003044015.1 similar to b0830 YP_003044016.1 similar to b0831 YP_003044017.1 similar to b0832 YP_003044018.1 similar to b0833 YP_003044019.1 similar to b0834 YP_003044020.1 catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit YP_003044021.1 BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing YP_003044022.1 similar to b0837 YP_003044023.1 similar to b0838 YP_003044024.1 penicillin-binding protein 6a; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains YP_003044025.1 similar to b0840 YP_003044026.1 similar to b0841 YP_003044027.1 similar to b0842 YP_003044028.1 similar to b0843 YP_003044029.1 similar to b0844 YP_003044030.1 similar to b0845 YP_003044031.1 similar to b0846 YP_003044065.1 similar to b1156 YP_003044070.1 similar to b0847 YP_003044071.1 similar to b0848 YP_003044072.1 functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase YP_003044073.1 YbjC; located in the same operon as the nfsA gene; member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress; induced by paraquat; regulated by SoxS; unknown function YP_003044074.1 NADPH-dependent; oxygen-insensitive; catalyzes the reduction of nitroaromatic compounds YP_003044075.1 responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 YP_003044076.1 similar to b0853 YP_003044077.1 similar to b0854 YP_003044078.1 part of the PotFGHI ATP-dependent putrescine transporter YP_003044079.1 similar to b0856 YP_003044080.1 similar to b0857 YP_003044081.1 similar to b0858 YP_003044082.1 RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA YP_003044083.1 similar to b0860 YP_003044084.1 with ArtPQJI acts to transport arginine across the inner membrane YP_003044085.1 with ArtPMJI transports arginine across the inner membrane YP_003044086.1 similar to b0863 YP_003044087.1 With ArtMQJI transports arginine across the inner membrane YP_003044088.1 induced during stationary phase and by acivicin (a glutamine analog); regulated by Lrp and RpoS YP_003044089.1 similar to b0866 YP_003044090.1 similar to b0867 YP_003044091.1 similar to b0868 YP_003044092.1 similar to b0869 YP_003044093.1 low- specificity; catalyzes the formation of acetaldehyde and glycine from L-threonine; acts on L-threonine, L-allo-threonine, L-threo-phenylserine, and L-erythro-phenylserine YP_003044094.1 catalyzes the formation of acetate from pyruvate YP_003044095.1 similar to b0872 YP_003044096.1 catalyzes the reduction of hydroxylamine to ammonia and water YP_003044097.1 similar to b0874 YP_003044098.1 porin involved in osmoregulation allowing water to move into and out of the cell in response to osmotic pressure YP_003044099.1 similar to b0876 YP_003044100.1 similar to b0877 YP_003044101.1 confers macrolide resistance via active drug efflux YP_003044102.1 with MacA is involved in the export of macrolide YP_003044103.1 inhibits DNA replication at both initiation and elongation steps; stationary phase and starvation inducible YP_003044104.1 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA YP_003044105.1 similar to b0882 YP_003044106.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_003044107.1 leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys YP_003044108.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c YP_003044109.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c YP_003044110.1 catalyzes the transfer of electrons from NADPH to thioredoxin; FAD/NAD(P) binding YP_003044111.1 mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system YP_003044112.1 DNA-binding membrane protein required for chromosome resolution and partitioning YP_003044113.1 participates with LolB in the incorporation of lipoprotein into the outer membrane YP_003044114.1 similar to b0892 YP_003044115.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_003044116.1 similar to b0894 YP_003044117.1 similar to b0895 YP_003044118.1 similar to b0896 YP_003044119.1 similar to b0897 YP_003044120.1 similar to b0898 YP_003044121.1 similar to b0899 YP_003044122.1 similar to b0900 YP_003044123.1 similar to b0901 YP_003044124.1 activates pyruvate formate-lyase 1 under anaerobic conditions YP_003044125.1 similar to b0903 YP_003044126.1 similar to b0904 YP_003044127.1 similar to b0905 YP_003044128.1 similar to b0906 YP_003044129.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine YP_003044130.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis YP_003044131.1 similar to b0909 YP_003044132.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP YP_003044133.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_003044134.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control YP_003044135.1 similar to b0913 YP_003044136.1 involved in the transport of lipid A across the inner membrane YP_003044137.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate YP_003044138.1 similar to b0916 YP_003044139.1 similar to b0917 YP_003044140.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS YP_003044141.1 similar to b0919 YP_003044142.1 similar to b0920 YP_003044143.1 involved in cellular zinc and cadmium homeostasis by binding excess metal ions to its cysteine sulfurs and histidine nitrogens; expression of smtA in cyanobacteria is repressed by SmtB at low concentrations of zinc; NO elicits release of Zn ions from SmtA YP_003044144.1 acts with MukB and MukE to condense the chromosome and allow for segregation during cell division YP_003044145.1 acts with MukB and MukF to condense the chromosome and allow for segregation during cell division YP_003044146.1 SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects YP_003044147.1 similar to b0925 YP_003044148.1 similar to b0926 YP_003044149.1 similar to b0927 YP_003044150.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate YP_003044151.1 outer membrane porin F; 1a; Ia; b YP_003044152.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_003044153.1 catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate YP_003044154.1 similar to b0932 YP_003044155.1 part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic substrate-binding subunit, SsuB the ATP-binding subunit and SsuC the permease YP_003044156.1 part of the ABC type transport system for alkanesulfonate SsuABC; SsuB the ATP-binding subunit and SsuC the permease YP_003044157.1 catalyzes the release of sulfite from alkanesulfonates YP_003044158.1 part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic subunit SsuB the ATP-binding subunit and SsuC the permease YP_003044159.1 similar to b0937 YP_003044160.1 similar to b0938 YP_003044161.1 similar to b0939 YP_003044162.1 similar to b0940 YP_003044163.1 similar to b0941 YP_003044164.1 similar to b0942 YP_003044165.1 similar to b0943 YP_003044166.1 similar to b0944 YP_003044167.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors YP_003044168.1 similar to b0946 YP_003044169.1 similar to b0947 YP_003044170.1 catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA YP_003044171.1 Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth YP_003044172.1 similar to b0950 YP_003044173.1 similar to b0951 YP_003044174.1 similar to b0952 YP_003044175.1 similar to b0953 YP_003044176.1 catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP YP_003044177.1 similar to b0955 YP_003044178.1 similar to b0956 YP_003044179.1 OmpA is believed to be a porin, involved in diffusion of nonspecific small solutes across the outer membrane. It is the most abundant integral protein of the outer membrane of E. coli, and it is known to play a role as a phage receptor, a mediator of F-factor dependent conjugation, and in maintaining the structural shape of the outer membrane; 3a; II*; G; d YP_003044180.1 similar to b0958 YP_003044181.1 similar to b0959 YP_003044182.1 similar to b0960 YP_003044183.1 similar to b0961 YP_003044184.1 catalyzes the ATP-dependent unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand YP_003044185.1 catalyzes the formation of methylglyoxal from glycerone phosphate YP_003044186.1 similar to b0964 YP_003044187.1 similar to b0965 YP_003044188.1 similar to b0966 YP_003044189.1 similar to b0967 YP_003044190.1 catalyzes the hydrolysis of acylphosphate YP_003044191.1 transfers sulfur from TusBCD complex to MnmA; involved in thiouridation of U34 position of some tRNAs YP_003044192.1 similar to b0970 YP_003044193.1 similar to b0972 YP_003044194.1 involved in hydrogen cycling during fermentative growth YP_003044195.1 similar to b0974 YP_003044196.1 HyaD; endopeptidase involved in the cleavage of the C-terminus end of HyaB (the large subunit of hydrogenase 1) YP_003044197.1 involved in processing hydrogenase proteins HyaA and HyaB YP_003044198.1 similar to b0977; protein involved in nickel incorporation into hydrogenase-1 proteins YP_003044199.1 similar to b0978 YP_003044200.1 similar to b0979 YP_003044201.1 similar to b0980 YP_003044202.1 similar to b0981 YP_003044203.1 Etk and Etp are a tyrosine kinase-tyrosine phosphatase pair, etp dephosphorylates etk YP_003044204.1 similar to b0983 YP_003044205.1 similar to b0984 YP_003044206.1 similar to b0985 YP_003044207.1 similar to b0986 YP_003044208.1 similar to b0987 YP_003044209.1 similar to b0989 YP_003044210.1 similar to b0990 YP_003044211.1 similar to b0991 YP_003044212.1 similar to b4517 YP_003044213.1 similar to b0992 YP_003044214.1 Member of the two-component regulatory system torS/torR involved in the anaerobic utilization of trimethylamine-N-oxide YP_003044215.1 periplasmic sensory protein associated with the TorRS two-component regulatory system YP_003044216.1 response regulator in two-component regulatory system with TorS; involved in regulation of trimethylamine N-oxide reductase genes YP_003044217.1 similar to b0996 YP_003044218.1 similar to b0997 YP_003044219.1 TorD; involved in the biogenesis of torA; acts on torA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor YP_003044220.1 with CpbA modulates the activity of the dnaK chaperone system; interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA YP_003044221.1 functional analog of DnaJ; co-chaperone with DnaK, molecular chaperone in an adaptive response to environmental stresses other than heat shock YP_003044222.1 similar to b1001 YP_003044223.1 similar to b1002 YP_003044224.1 similar to b1003 YP_003044225.1 stationary phase protein that binds TrpR repressor YP_003044226.1 similar to b4518 YP_003044227.1 similar to b1006 YP_003044228.1 similar to b1007 YP_003044229.1 similar to b1008 YP_003044230.1 similar to b1009 YP_003044231.1 similar to b1010 YP_003044232.1 similar to b1011 YP_003044233.1 similar to b1012 YP_003044234.1 similar to b1013 YP_003044235.1 proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichai coli this protein also self-regulates transcription via a DNA-binding domain at the N-terminus; forms dimers and is a peripherally membrane-associated protein YP_003044236.1 similar to b1015 YP_003044237.1 similar to b1016-b1017(b4490) YP_003044238.1 similar to b1018 YP_003044239.1 similar to b1019 YP_003044240.1 similar to b1020 YP_003044241.1 in Yersinia this gene is involved in biofilm formation and hemin adsorption; in Escherichia coli it is involved in PGA biosynthesis and export YP_003044242.1 predicted polysaccharide polymerase involved in biofilm formation; required for the synthesis of the beta-1,6-N-acetylglucosamine polysaccharide; PgaC; in Yersinia the HmsR protein is an inner membrane protein YP_003044243.1 in Yersinia this protein is involved in biofilm formation and hemin adsorption; related protein PgaB in Escherichia coli is an outer membrane N-deacetylase involved in poly-beta-1,6-N-acetyl-D-glucosamine (PGA) export YP_003044244.1 outer membrane protein essential for the synthesis of poly-beta-1,6-N-acetyl-D-glucosamine (PGA); adhesin required for biofilm formation; PgaA (HmsH) seems to translocate and/or dock PGA to the cell surface; member of the hmsHFRS (ycdSRQP or pgaABCD in Escherichia coli) operon in Yersinia YP_003044245.1 similar to b1025 YP_003044248.1 similar to b1033 YP_003044249.1 similar to b1034 YP_003044250.1 similar to b1035 YP_003044251.1 similar to b1036 YP_003044252.1 similar to b1037 YP_003044253.1 nucleator protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex YP_003044254.1 chaperone-like protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex YP_003044255.1 activates the csgBA and csgDEFG operons involved in biofilm formation YP_003044256.1 CsgB; functions as a nucleator in the assembly of curli (coiled surface structures) on the cell surface YP_003044257.1 similar to b1042 YP_003044258.1 involved in autoagglutination of curliated cells; not involved in production of curli fibers YP_003044259.1 similar to b1044 YP_003044260.1 similar to b1045 YP_003044261.1 similar to b1046 YP_003044262.1 required for the transfer of succinyl residues to the glucan backbone YP_003044263.1 involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan YP_003044264.1 necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space YP_003044265.1 similar to b1050 YP_003044266.1 similar to b1051 YP_003044267.1 Confers resistance to fosfomycin and deoxycholate YP_003044268.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA YP_003044269.1 similar to b1055 YP_003044270.1 similar to b1056 YP_003044271.1 similar to b1057 YP_003044272.1 similar to b1058 YP_003044273.1 catalyzes the demethylation of N-methyl-L-tryptophan forming L-tryptophan and formaldehyde; FAD-binding; can also catalyze the demethylation of other N-methyl amino acids YP_003044274.1 BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing YP_003044275.1 similar to b1061 YP_003044276.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis YP_003044277.1 similar to b1063 YP_003044278.1 cofactor involved in the reduction of disulfides YP_003044279.1 Confers resistance to norfloxacin and enoxacin YP_003044280.1 similar to b1066 YP_003044281.1 similar to b1067 YP_003044282.1 similar to b1068 YP_003044283.1 similar to b1069 YP_003044284.1 similar to b1070 YP_003044285.1 regulates the flagellar specific sigma28 transcription factor YP_003044286.1 required for the assembly of the flagellar basal body P-ring YP_003044287.1 with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella YP_003044288.1 with FlgF and B makes up the proximal portion of the flagellar basal body rod YP_003044289.1 acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; in V. parahaemolyticus one set used for lateral flagella production and the other is used for the polar flagella production YP_003044290.1 the hook connects flagellar basal body to the flagellar filament YP_003044291.1 FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod YP_003044292.1 makes up the distal portion of the flagellar basal body rod YP_003044293.1 part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod YP_003044294.1 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum YP_003044295.1 Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space YP_003044296.1 with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook YP_003044297.1 with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of this and other flagellar genes YP_003044298.1 bifunctional ribonuclease E/endoribonuclease/RNA-binding protein/RNA degradosome binding protein; forms part of the membrane-associated degradosome complex along with PNPase, RhlB, and enolase YP_003044299.1 similar to b1085 YP_003044300.1 catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA YP_003044301.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell YP_003044302.1 similar to b1088 YP_003044303.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not YP_003044304.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY YP_003044305.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs YP_003044306.1 similar to b1092 YP_003044307.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_003044308.1 carries the fatty acid chain in fatty acid biosynthesis YP_003044309.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_003044310.1 catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate YP_003044311.1 similar to b1097 YP_003044312.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) YP_003044313.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA YP_003044314.1 similar to b1100 YP_003044315.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_003044316.1 similar to b1102 YP_003044317.1 similar to b1103 YP_003044318.1 similar to b1104 YP_003044319.1 similar to b1105 YP_003044320.1 catalyzes the phosphorylation of thiamine to thiamine phosphate YP_003044321.1 hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides YP_003044322.1 similar to b1108 YP_003044323.1 similar to b1109 YP_003044324.1 similar to b1110 YP_003044325.1 similar to b1111 YP_003044326.1 similar to b1112 YP_003044327.1 similar to b1113 YP_003044328.1 similar to b1114 YP_003044329.1 similar to b1115 YP_003044330.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane YP_003044331.1 outer membrane specific; part of transporter complex lolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone YP_003044332.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane YP_003044335.1 Modulates the activities of several enzymes which are inactive in their acetylated form YP_003044336.1 similar to b1121 YP_003044337.1 similar to b1122 YP_003044338.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotD is a periplasmic component that binds the substrate YP_003044339.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component YP_003044340.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component YP_003044341.1 functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase YP_003044342.1 catalyzes the release of the N-terminal amino acid from a tripeptide YP_003044343.1 similar to b1128 YP_003044344.1 similar to b1129 YP_003044345.1 response regulator in two-component regulatory system with PhoQ; involved in magnesium starvation and stress YP_003044346.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_003044347.1 HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis YP_003044348.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_003044349.1 similar to b1134 YP_003044350.1 catalyzes the formation of pseudouridine from uracil-2457 in 23S ribosomal RNA YP_003044351.1 Converts isocitrate to alpha ketoglutarate YP_003044352.1 similar to b1160 YP_003044353.1 similar to b1161 YP_003044354.1 similar to b1162 YP_003044355.1 similar to b1163 YP_003044356.1 similar to b1164 YP_003044357.1 similar to b1165 YP_003044358.1 similar to b1166 YP_003044359.1 similar to b1167 YP_003044360.1 similar to b1168 YP_003044361.1 similar to b4520 YP_003044362.1 similar to b1171 YP_003044363.1 similar to b1172 YP_003044364.1 similar to b1173 YP_003044365.1 works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell YP_003044366.1 ATPase; with MinC inhibits cell division by blocking formation of the polar Z ring septums YP_003044367.1 blocks the formation of polar Z-ring septums YP_003044368.1 similar to b1177 YP_003044369.1 similar to b1178 YP_003044370.1 similar to b1179 YP_003044371.1 similar to b1180 YP_003044372.1 similar to b1181 YP_003044373.1 binds with UmuC protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization YP_003044374.1 binds processed UmuD protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization YP_003044375.1 disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein YP_003044376.1 involved in regulation of intracellular pH under alkaline conditions YP_003044377.1 Multifunctional regulator of fatty acid metabolism YP_003044378.1 similar to b1188 YP_003044379.1 catalyzes the oxidative deamination of D-amino acids YP_003044380.1 catabolic enzyme, converts L-alanine to D-alanine which is then oxidized to pyruvate by dadA YP_003044381.1 the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli YP_003044382.1 catalyzes the release of D-alanine from L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanine YP_003044383.1 similar to b1193 YP_003044384.1 similar to b1194; protein involved in flagellar function YP_003044385.1 similar to b1195 YP_003044386.1 similar to b1196 YP_003044387.1 periplasmic; catalyzes the hydrolysis of trehalose to glucose which can then be imported into the cell YP_003044388.1 phosphotransferaese subunit; phosphorylates dihydroxyacetone along with DhaK/DhaL YP_003044389.1 with DhaK and DhaM catalyzes the phosphorylation of dihydroxyacetone YP_003044390.1 with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase YP_003044391.1 Positively regulates the dhaKLM operon from a sigma-70 promoter YP_003044392.1 similar to b1202 YP_003044393.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_003044394.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_003044395.1 YchH; transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria; ychH presents a class II promoter to bind CRP; unknown function YP_003044396.1 putative role in sulfate transport across the inner membrane; member of the SulP family of sulfate transporters; seems to mediate transport via sulfate/proton symport YP_003044397.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP YP_003044398.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis YP_003044399.1 Incorporates lipoproteins in the outer membrane after they are released by the LolA protein YP_003044400.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins YP_003044401.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_003044402.1 HemK; PrmC; transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB YP_003044403.1 similar to b1213 YP_003044404.1 similar to b1214 YP_003044405.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis YP_003044406.1 similar to b4419 YP_003044407.1 similar to b4421 YP_003044408.1 similar to b4423 YP_003044409.1 similar to b1216 YP_003044410.1 in Escherichia coli this protein putatively regulates the sodium/proton (also pH-independent calcium/proton) antiporter chaA; has weak affinity for calcium and magnesium ions YP_003044411.1 similar to b1218 YP_003044412.1 similar to b1219 YP_003044413.1 similar to b1220 YP_003044414.1 two-component response regulator NarL; phosphorylated by NarQ; activates transcription of nitrate and nitrite reductase genes and represses transcription of fumarate reductase YP_003044415.1 similar to b1222 YP_003044416.1 similar to b1223 YP_003044417.1 similar to b1224 YP_003044418.1 similar to b1225 YP_003044419.1 similar to b1226 YP_003044420.1 similar to b1227 YP_003044421.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine YP_003044422.1 similar to b1233 YP_003044423.1 similar to b1234 YP_003044424.1 similar to b1235 YP_003044425.1 together with GalF subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose YP_003044426.1 similar to b1237 YP_003044427.1 catalyzes the formation of thymidine 5'-phosphate from thymidine YP_003044428.1 similar to b1241 YP_003044429.1 similar to b1242 YP_003044430.1 similar to b1243 YP_003044431.1 similar to b1244 YP_003044432.1 similar to b1245 YP_003044433.1 similar to b1246 YP_003044434.1 similar to b1247 YP_003044435.1 highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein YP_003044436.1 catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol) YP_003044437.1 similar to b1250 YP_003044438.1 unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity YP_003044439.1 membrane spanning protein in TonB-ExbB-ExbD complex; transduces proton motive force of the cytoplasmic membrane to outer membrane transporters; involved in the transport of ron-siderophore complexes, vitamin B12 and colicins YP_003044440.1 YciA; hydrolase that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA; member of the the acyl coenzyme A hydrolase family of proteins YP_003044441.1 Involved in cell division; probably involved in intracellular septation YP_003044442.1 similar to b1255 YP_003044443.1 receptor for colicin S4 YP_003044444.1 similar to b1257 YP_003044445.1 similar to b1258 YP_003044446.1 similar to b1259 YP_003044447.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis YP_003044448.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_003044449.1 monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate YP_003044450.1 bifunctional anthranilate synthase II/anthranilate phosphoribosyltransferase; TrpD; forms a heterotetramer with Trp E and the complex catalyzes the formation of anthranilate from chorismate and glutamine; also catalyzes the formation of N-(5-phospho-D-ribosyl)-anthranilate from athranilate and 5-phospho-alpha-D-ribose 1-diphosphate; functions in tryptophan biosynthesis YP_003044451.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine YP_003044453.1 similar to b1266 YP_003044454.1 similar to b1267 YP_003044457.1 catalyzes the synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA YP_003044458.1 catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide YP_003044459.1 similar to b1271 YP_003044460.1 SohB; periplasmic protein; member of the peptidase S49 family YP_003044461.1 similar to b1273 YP_003044462.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity YP_003044463.1 LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation YP_003044464.1 Catalyzes the conversion of citrate to isocitrate YP_003044465.1 catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate YP_003044466.1 similar to b1278 YP_003044467.1 similar to b1279 YP_003044468.1 similar to b1280 YP_003044469.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase YP_003044470.1 involved in start site selection during the initiation of translation YP_003044471.1 similar to b1283 YP_003044472.1 similar to b1284 YP_003044473.1 c-di-GMP phosphodiesterase; probably degrades signalling molecule c-di-GMP YP_003044474.1 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction YP_003044475.1 similar to b1287 YP_003044476.1 Catalyzes a key regulatory step in fatty acid biosynthesis YP_003044477.1 similar to b1289 YP_003044478.1 similar to b1290 YP_003044479.1 similar to b1291 YP_003044480.1 similar to b1292 YP_003044481.1 similar to b1293 YP_003044482.1 similar to b1294 YP_003044483.1 similar to b1295 YP_003044484.1 similar to b1296 YP_003044485.1 similar to b1297 YP_003044486.1 catalyzes the degradation of gamma-glutamyl-gamma-aminobutyrate into glutamate and gamma-aminobutyrate YP_003044487.1 regulates genes involved in putrescine degradation YP_003044488.1 catalyzes the formation of gamma-glutamyl-gamma-aminobutyrate from Gamma-glutamyl-gamma-aminobutyraldehyde; involved in putrescine degradation YP_003044489.1 similar to b1301 YP_003044490.1 putrescine-inducible GABA aminotransferase; catalyzes the formation of glutamate and succinate semialdehyde from 4-aminobutyrate and 2-oxoglutarate YP_003044491.1 transcriptional activator for pspABCE which are induced in response to phage proteins, membrane altering stresses, and impaired proton expor YP_003044492.1 involved in maintaining membrane potential under membrane stress conditions; also acts as a negative transcriptional regulator of the phage shock protein (psp) operon(pspABCDE) by regulating the transcriptional activator PspF YP_003044493.1 acts together with PspC to induce psp operon during infection with phage, exposure to ethanol or osmotic shock; forms a complex with PspA and C; PspC is required for PspAB binding YP_003044494.1 with PsbB forms toxin/antitoxin pair; activates the psp operon in response to phage infection, exposure to ethanol or osmotic shock YP_003044495.1 similar to b1307 YP_003044496.1 rhodanese; catalyzes the formation of thiocyanate from thiosulfate and hydrogen cyanide YP_003044497.1 similar to b1309 YP_003044498.1 similar to b1310 YP_003044499.1 similar to b1311 YP_003044500.1 similar to b1312 YP_003044501.1 similar to b1313 YP_003044502.1 similar to b1314 YP_003044503.1 similar to b1315 YP_003044504.1 similar to b1316 YP_003044505.1 similar to b1317 YP_003044506.1 similar to b1318; extended C-terminal; pseudo in K-12MG1655 YP_003044507.1 similar to b1319 YP_003044508.1 similar to b1320 YP_003044509.1 similar to b1321 YP_003044510.1 similar to b1322 YP_003044511.1 regulates genes involved in the biosynthesis and transport of aromatic amino acids YP_003044512.1 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein YP_003044513.1 similar to b1325 YP_003044514.1 similar to b1326 YP_003044515.1 similar to b1327 YP_003044516.1 similar to b1328 YP_003044517.1 similar to b1329 YP_003044518.1 similar to b1330 YP_003044519.1 similar to b1332 YP_003044520.1 with UspC and UspD is involved in resistance to UV irradiation YP_003044521.1 Global transcription factor that controls the expression of over 100 target genes in response to anoxia YP_003044522.1 similar to b1335 YP_003044523.1 similar to b1336 YP_003044524.1 similar to b1337 YP_003044525.1 similar to b1338 YP_003044526.1 similar to b1339 YP_003044527.1 similar to b1340 YP_003044528.1 similar to b1341 YP_003044529.1 similar to b1342 YP_003044530.1 exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA YP_003044531.1 TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs YP_003044532.1 similar to b1345 YP_003044533.1 similar to b1346 YP_003044534.1 Rac prophage YP_003044535.1 seems to be involved in restriction alleviation and enhancement of modification by EcoKI, but not in restriction alleviation of type III restriction systems; Rac prophage YP_003044536.1 similar to b1349 YP_003044537.1 The RecE (also known as exonuclease VIII) pathway is an alternative pathway for the initiation of homologous recombination in Escherichia coli. The RecE pathway is activated in recB, recC sbcA (suppressors of recB and recC) mutants. Activation of the RecE pathway results in the production of at least two phage proteins relevant for recombinational repair. RecE is a duplex DNA-specific exonuclease which produces 3' overhangs in duplex DNA by preferentially degrading the 5'-ending strands. Recombinational repair of E.coli chromosomal DNA involves as well other proteins: RecA, RecF, RecJ, RecO, RecR, and RuvC. YP_003044538.1 Rac prophage hypothetical protein YP_003044539.1 similar to b4526 YP_003044540.1 Rac prophage Kil protein; Kil overexpression leads to morphological defects and inhibits cell division YP_003044541.1 similar to b1353 YP_003044542.1 similar to b4527 YP_003044543.1 similar to b1355 YP_003044547.1 similar to b1554 YP_003044548.1 similar to b1362 YP_003044549.1 similar to b1363 YP_003044550.1 similar to b1365 YP_003044555.1 similar to b1374 YP_003044556.1 similar to b1375 YP_003044557.1 similar to b1376 YP_003044558.1 similar to b1377 YP_003044559.1 similar to b1378 YP_003044560.1 similar to b4529 YP_003044561.1 similar to b1379 YP_003044562.1 similar to b1380 YP_003044563.1 similar to b1381 YP_003044564.1 similar to b1382 YP_003044565.1 similar to b1383 YP_003044566.1 activator of genes involved in phenylacetic acid catabolism YP_003044567.1 similar to b1385 YP_003044568.1 similar to b1386 YP_003044571.1 similar to b1406 YP_003044572.1 similar to b1407 YP_003044573.1 similar to b1408 YP_003044574.1 similar to b1409 YP_003044575.1 similar to b1410 YP_003044576.1 similar to b1411 YP_003044577.1 FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds YP_003044578.1 involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain YP_003044579.1 similar to b1414 YP_003044580.1 NAD-linked YP_003044581.1 similar to b1416-b1417(b4493); pseudo in K-12 MG1655 YP_003044584.1 B-type di-heme cytochrome with a major alpha-absorption peak at 561 nm and a minor peak at 555 nm YP_003044585.1 similar to b1419 YP_003044586.1 similar to b4428 YP_003044587.1 similar to b1420 YP_003044588.1 similar to b1421 YP_003044589.1 similar to b1422 YP_003044590.1 similar to b1423 YP_003044591.1 involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans YP_003044592.1 similar to b1425; deleted from K-12 MG1655 YP_003044593.1 similar to b1426 YP_003044594.1 similar to b1427 YP_003044595.1 similar to b1428 YP_003044596.1 similar to b1429 YP_003044597.1 with TehA confers resistance to tellurite YP_003044598.1 similar to b1431 YP_003044599.1 similar to b1432 YP_003044600.1 similar to b1433 YP_003044601.1 similar to b1434 YP_003044602.1 similar to b1435 YP_003044603.1 similar to b1436 YP_003044604.1 similar to b1438 YP_003044605.1 similar to b1439 YP_003044606.1 similar to b1440 YP_003044607.1 similar to b1441 YP_003044608.1 similar to b1442 YP_003044609.1 similar to b1443 YP_003044610.1 catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation YP_003044611.1 similar to b1445 YP_003044612.1 similar to b1446 YP_003044613.1 similar to b1447 YP_003044614.1 similar to b1448 YP_003044615.1 similar to b1449 YP_003044616.1 similar to b1450 YP_003044617.1 similar to b1451 YP_003044618.1 similar to b1452 YP_003044619.1 similar to b1453 YP_003044620.1 similar to b1454 YP_003044621.1 similar to b1455 YP_003044623.1 similar to b1456 YP_003044624.1 similar to b1457 YP_003044625.1 similar to b1458 YP_003044626.1 similar to b1459 YP_003044627.1 similar to b1460 YP_003044628.1 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown YP_003044629.1 similar to b1462 YP_003044630.1 similar to b1463 YP_003044631.1 similar to b1465 YP_003044632.1 similar to b1466 YP_003044633.1 similar to b1467 YP_003044634.1 similar to b1468 YP_003044635.1 similar to b1469 YP_003044636.1 similar to b1470 YP_003044637.1 similar to b1471 YP_003044638.1 similar to b1472 YP_003044639.1 similar to b1473 YP_003044640.1 similar to b1474; selenocysteine YP_003044641.1 similar to b1475 YP_003044642.1 nitrate-inducible, cytochrome b556(fdn) component of formate dehydrogenase YP_003044643.1 similar to b1477 YP_003044644.1 similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs YP_003044645.1 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate YP_003044646.1 protein D; stationary-phase-induced ribosome-associated; in Escherichia coli this protein becomes associated with the ribosome; expression increases during stationary phase YP_003044647.1 similar to b1481 YP_003044648.1 similar to b1482 YP_003044649.1 similar to b1483 YP_003044650.1 similar to b1484 YP_003044651.1 similar to b1485 YP_003044652.1 similar to b1486 YP_003044653.1 similar to b1487 YP_003044654.1 catalyzes the hydrolysis of D-alanyl-D-alanine dipeptide: Zn dependent; involved in peptidoglycan synthesis YP_003044655.1 heme-regulated phosphodiesterase with phosphodiesterase activity with cAMP but not with cGMP, bis(p-nitrophenyl) phosphate or p-nitrophenyl phosphate YP_003044656.1 similar to b1490 YP_003044657.1 similar to b1491 YP_003044658.1 similar to b1492 YP_003044659.1 similar to b1493 YP_003044660.1 similar to b1494 YP_003044661.1 similar to b1495 YP_003044662.1 similar to b1496 YP_003044663.1 similar to b1497 YP_003044664.1 similar to b1498 YP_003044665.1 regulates the cellular response to acid resistance YP_003044666.1 similar to b1500; deleted from K-12 MG1655 YP_003044667.1 in Escherichia coli it may be involved in repression of type III secretion system (TTSS) genes of the host cell; involved with increased resistance to low pH; member of the prokaryotic molybdopterin-containing oxidoreductase family YP_003044668.1 similar to b1502 YP_003044669.1 similar to b1503 YP_003044670.1 similar to b1504 YP_003044671.1 similar to b1505 YP_003044672.1 similar to b1506 YP_003044673.1 similar to b1507 YP_003044674.1 similar to b1508 YP_003044675.1 similar to b1515 YP_003044676.1 similar to b1516 YP_003044677.1 similar to b1517 YP_003044678.1 similar to b1518 YP_003044679.1 catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate YP_003044680.1 similar to b1520 YP_003044681.1 catalyzes the formation of D-tagaturonate from D-altronate YP_003044682.1 similar to b1522 YP_003044683.1 similar to b1523 YP_003044684.1 catalyzes the formation of glutamate from glutamine YP_003044685.1 in Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase YP_003044686.1 similar to b1526 YP_003044687.1 similar to b1527 YP_003044688.1 similar to b1528 YP_003044689.1 protein involved in resistance to different drugs (tetracycline, chloramphenicol, beta-lactams, and quinolones); part of the multiple antibiotic resistance (mar) locus, which is composed by the genes marC and marRAB; unknown function YP_003044692.1 Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes YP_003044693.1 transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype; also activates sodA, zwf and micF YP_003044694.1 similar to b1532 YP_003044695.1 similar to b1533 YP_003044696.1 YdeF; uncharacterized member of the major facilitator superfamily (MFS) of transporters YP_003044697.1 similar to b1535 YP_003044698.1 similar to b1536 YP_003044699.1 similar to b1537 YP_003044700.1 similar to b1538 YP_003044701.1 NADP(+)-dependent; catalyzes the formation of 2-aminomalonate-semialdehyde from L-serine; can also use 3-hydroxybutyrate, 3-hydroxy-isobutyrate, D-threonine, L-allo-threonine,D-serine YP_003044702.1 similar to b1540 YP_003044703.1 similar to b1541 YP_003044704.1 similar to b1542 YP_003044705.1 similar to b1543 YP_003044706.1 similar to b1544 YP_003044707.1 similar to b1545 YP_003044711.1 similar to b1372 YP_003044712.1 similar to b1369-b1370 YP_003044716.1 similar to b0559 YP_003044717.1 similar to b1550 YP_003044718.1 similar to b1551 YP_003044720.1 similar to b1552 YP_003044721.1 similar to b1553 YP_003044722.1 similar to b1554 YP_003044723.1 similar to b1555 YP_003044724.1 similar to b1556 YP_003044729.1 lipocalin; globomycin-sensitive outer membrane lipoprotein YP_003044730.1 from lambdoid prophage DLP12 YP_003044731.1 similar to b1560 YP_003044733.1 similar to b1561 YP_003044734.1 similar to b1562 YP_003044739.1 similar to b1568 YP_003044741.1 The transcriptional repressor of DicA (divison cell) has a hypothetical DNA binding domain. It represses the transcription of dicB and dicC, but its specific role in cellular replication and mode of action are still unknown. YP_003044745.1 similar to b1575 YP_003044746.1 similar to b1576 YP_003044747.1 similar to b1577 YP_003044749.1 similar to b1580 YP_003044750.1 similar to b1581 YP_003044751.1 similar to b1582 YP_003044752.1 similar to b1583 YP_003044753.1 similar to b1584 YP_003044754.1 similar to b1585 YP_003044755.1 similar to b1586 YP_003044756.1 similar to b1587 YP_003044757.1 similar to b1588 YP_003044758.1 similar to b1589 YP_003044759.1 similar to b1590 YP_003044760.1 binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane YP_003044761.1 similar to b1592 YP_003044762.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium YP_003044763.1 similar to b1594 YP_003044764.1 similar to b1595 YP_003044765.1 similar to b1596 YP_003044766.1 required for growth and survival under moderately acid conditions YP_003044767.1 similar to b1598 YP_003044768.1 with MdtJ is involved in resistance to deoxycholate, nalidixic acid, fosfomycin, and SDS YP_003044769.1 with MdtI is involved in resistance to deoxycholate , nalidixic acid, fosfomycin, and SDS YP_003044770.1 transport of quorum-sensing signal; mutations in this gene alters the transport of the quorum-sensing signal autoinducer 2 (AI-2) which affects expression of a large number of genes YP_003044771.1 catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme YP_003044772.1 forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm YP_003044773.1 similar to b1604 YP_003044774.1 similar to b1605 YP_003044775.1 similar to b1606 YP_003044776.1 similar to b1607 YP_003044777.1 response regulator in two-component regulatory system with RstB YP_003044778.1 similar to b1609 YP_003044779.1 binds to DNA replication terminator sequences to prevent passage of replication forks YP_003044780.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle YP_003044781.1 similar to b1612 YP_003044782.1 similar to b1613 YP_003044783.1 similar to b1614 YP_003044784.1 similar to b1615 YP_003044785.1 similar to b1616 YP_003044786.1 similar to b1617 YP_003044787.1 similar to b1618 YP_003044788.1 Acts on the hydroxyl group at position 7 of the steroid frame YP_003044789.1 regulates malXY which are involved in maltose-glucose transport YP_003044790.1 phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS); catalyzes the phosphorylation of maltose and glucose concomitant with their translocation across the cell membrane; component IIB catalyzes the phosphorylation of the sugar molecule; IIC forms the translocation channel and contains the substrate specific binding site YP_003044791.1 similar to b1622 YP_003044792.1 catalyzes the formation of inosine from adenosine YP_003044793.1 similar to b1624 YP_003044794.1 similar to b4409 YP_003044795.1 YdgT; in E. coli, when complexed with H-NS or StpA binds a 26 base-pair DNA sequence of oriC; seems to play a role in optimizing the activity of oriC; non-essential; Hha protein paralog; in an hha mutant background, cnu is overexpressed and can compensate hha-induced phenotypes YP_003044796.1 similar to b1626 YP_003044797.1 similar to b1627 YP_003044798.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen YP_003044799.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen YP_003044800.1 RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents YP_003044801.1 part of membrane-bound complex hought to be involved in electron transport to nitrogen YP_003044802.1 in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase YP_003044803.1 DNA-(apurinic or apyrimidinic site) lyase; has apurinic or apyrimidinic endonuclease activity and DNA N-glycosylase activity; removed damaged DNA at cytosines, thymines and guanines YP_003044804.1 mutations in this gene confer resistance to the toxic peptide alafosfalin in Salmonella typhimurium; member of proton-dependent oligopeptide transport (POT) system family; in Escherichia coli this gene is regulated by OmpR although not via osmoregulation YP_003044805.1 similar to b1635 YP_003044806.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal YP_003044807.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr) YP_003044808.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate YP_003044809.1 MliC; membrane-bound lysozyme inhibitor of c-type lysozyme YP_003044810.1 catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling YP_003044811.1 similar to b1641 YP_003044812.1 Transcription regulator that can both activate or repress expression YP_003044813.1 similar to b1643 YP_003044814.1 similar to b1644 YP_003044815.1 similar to b1645 YP_003044816.1 SodC; copper and zinc binding; converts superoxide radicals to hydrogen peroxide and water YP_003044817.1 similar to b1647 YP_003044818.1 similar to b1648 YP_003044819.1 similar to b1649 YP_003044820.1 FMN-linked; catalyzes the formation of N-ethylsuccinimide from N-ethylmaleimide YP_003044821.1 Ni-dependent; catalyzes the formation of S-lactoylglutathione from methylglyoxal and glutathione YP_003044822.1 Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A) YP_003044823.1 similar to the DNA and RNA helicase superfamily II and eukaryotic DEAD family of helicases; longest known protein in E. coli YP_003044824.1 similar to b1654 YP_003044825.1 similar to b1655 YP_003044826.1 SodB; iron binding; present under aerobic and anaerobic conditions; destroys free radicals YP_003044827.1 similar to b1657 YP_003044829.1 binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers YP_003044830.1 similar to b1659 YP_003044831.1 uncharacterized member of the major facilitator superfamily (MFS) YP_003044832.1 catalyzes the transfer of a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge YP_003044833.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine YP_003044834.1 NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones YP_003044835.1 similar to b1664 YP_003044836.1 similar to b1667 YP_003044837.1 similar to b1668 YP_003044838.1 similar to b1669 YP_003044839.1 similar to b1670 YP_003044840.1 similar to b1671 YP_003044841.1 similar to b1672 YP_003044842.1 similar to b1673 YP_003044843.1 similar to b1674 YP_003044844.1 similar to b1675 YP_003044845.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_003044846.1 similar to b1677 YP_003044847.1 similar to b1678 YP_003044848.1 Acts with SufS to catalyze the formation of L-alanine from L-cysteine YP_003044849.1 catalyzes the formation of L-alanine and selenide or sulfanylcysteine from selenocysteine or cysteine YP_003044850.1 with SufBC activates cysteine desulfurase SufS YP_003044851.1 part of SUF system involved in inserting iron-sulfur clusters into proteins; in Escherichia coli this protein forms a complex with SufBD; the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE YP_003044852.1 with SufCD activates cysteine desulfurase SufS YP_003044853.1 functions as a scaffold on which iron-sulfur clusters ([2Fe-2S]; [4Fe-4S]) are assembled; forms a homodimer; similar to IscA protein YP_003044854.1 similar to b1685 YP_003044855.1 similar to b1686 YP_003044856.1 similar to b1687 YP_003044857.1 YdiK; inner membrane protein; ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated; unknown function YP_003044858.1 similar to b1689 YP_003044859.1 similar to b1691 YP_003044860.1 YdiB; quinate/shikimate dehydrogenase from Escherichia coli uses both NAD and NAD(P) to convert quinate and shikimate to 3-dehydroquinate and 3-dehydroshikimate YP_003044861.1 catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis YP_003044862.1 similar to b1694 YP_003044863.1 may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain YP_003044864.1 similar to b1696 YP_003044865.1 YdiO, YdiQ, YdiR, YdiS, and YdiT may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain YP_003044866.1 May play a role in a redox process YP_003044867.1 similar to b1699 YP_003044868.1 similar to b1700 YP_003044869.1 acts in anaerobic beta-oxidation of fatty acids; possible ligase/synthase involved in anaerobic growth on fatty acids YP_003044870.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_003044871.1 similar to b1703 YP_003044872.1 tryptophan sensitive; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate YP_003044873.1 similar to b1705 YP_003044874.1 similar to b1706 YP_003044875.1 similar to b1707 YP_003044876.1 similar to b1708 YP_003044877.1 ATP-binding protein that acts with the transmembrane protein BtuC and the solute binding protein BtuF to transport vitamin B12 into the cell YP_003044878.1 similar to glutathione peroxidase; member of the btuCED operon which is required for vitamin B12 transport across the inner membrane YP_003044879.1 with BtuD and BtuF transports vitamin B12 into the cell YP_003044880.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control YP_003044881.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_003044882.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_003044884.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_003044885.1 similar to b1717 YP_003044886.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits YP_003044887.1 catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_003044888.1 similar to b4535 YP_003044889.1 similar to b1722 YP_003044890.1 similar to b1723 YP_003044891.1 similar to b1724 YP_003044892.1 similar to b1725 YP_003044893.1 similar to b1726 YP_003044894.1 YniC; catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate, mannose 6-phosphate and p-nitrophenyl phosphate YP_003044895.1 similar to b1728 YP_003044896.1 similar to b1729 YP_003044897.1 similar to b1730 YP_003044898.1 similar to b1731 YP_003044899.1 Catalase HPII; monofunctional catalase that decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide YP_003044900.1 similar to b1733 YP_003044901.1 similar to b1734 YP_003044902.1 represses the celABCDF-ydjC operon involved in carbon uptake YP_003044903.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake YP_003044904.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake YP_003044905.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake YP_003044906.1 osmotically-inducible lipoprotein E; activator of ntr-like gene protein YP_003044907.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers YP_003044908.1 3' incision activity; acts with UvrC YP_003044909.1 similar to b1742 YP_003044910.1 periplasmic protein induced by stress response via Cpx and BaeSR system; similar to CpxP YP_003044911.1 catalyzes the formation of succinate and glutamate from N(2)-succinylglutamate in arginine catabolism YP_003044912.1 catalyzes the hydrolysis of 2-N-succinylarginine into 2-N-succinylornithine, ammonia and carbon dioxide in arginine degradation YP_003044913.1 a high throughput screen identified this enzyme as an aldehyde dehydrogenase with broad substrate specificity; converts succinylglutamate semialdehyde and NAD to succinylglutamate and NADH YP_003044914.1 similar to b1747 YP_003044915.1 catalyzes the transamination of 2-N-succinylornithine and alpha-ketoglutarate into 2-N-succinylglutamate semialdehyde and glutamate; also functions as the catabolic acetylornithine aminotransferase catalyzing the formation of 2-N-acetylglutamate semialdehyde and glutamate from 2-N-acetylornithine and alpha-ketoglutarate YP_003044916.1 removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction YP_003044917.1 similar to b1750 YP_003044918.1 similar to b1752 YP_003044919.1 similar to b1753 YP_003044920.1 similar to b1754 YP_003044921.1 similar to b1755 YP_003044922.1 similar to b1756 YP_003044923.1 similar to b1757 YP_003044924.1 similar to b1758 YP_003044925.1 similar to b1759 YP_003044926.1 similar to b1760 YP_003044927.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer YP_003044928.1 similar to b1762 YP_003044929.1 decatenates replicating daughter chromosomes YP_003044930.1 catalyzes the formation of selenophosphate from selenide and ATP YP_003044931.1 similar to b1765 YP_003044932.1 SppA; catalyzes the degradation of cleaved signal peptides; essential to maintain secretion of mature proteins across the membrane YP_003044933.1 converts asparagine to aspartate and ammonia YP_003044934.1 catalyzes the formation of nicotinate from nicotinamide in NAD biosynthesis and the formation of pyrazinoate from pyrazinamide YP_003044935.1 similar to b1769 YP_003044936.1 similar to b1770 YP_003044937.1 similar to b1771 YP_003044938.1 similar to b1772 YP_003044939.1 similar to b1773 YP_003044940.1 similar to b1774 YP_003044941.1 similar to b1775 YP_003044942.1 similar to b1776 YP_003044943.1 similar to b1777 YP_003044944.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress YP_003044945.1 similar to b1779 YP_003044946.1 similar to b1780 YP_003044947.1 similar to b1781 YP_003044948.1 similar to b1782 YP_003044949.1 similar to b1783 YP_003044950.1 similar to b1784 YP_003044951.1 similar to b1785 YP_003044952.1 similar to b1786 YP_003044953.1 similar to b1787 YP_003044954.1 similar to b1788 YP_003044955.1 similar to b1789 YP_003044956.1 similar to b1790 YP_003044957.1 similar to b1791 YP_003044958.1 similar to b1792 YP_003044959.1 similar to b1793 YP_003044960.1 similar to b1794 YP_003044961.1 similar to b1795 YP_003044962.1 similar to b1796 YP_003044963.1 similar to b1797 YP_003044965.1 similar to b1798 YP_003044966.1 similar to b1799 YP_003044967.1 similar to b1800 YP_003044968.1 member of the betaine, carnitine, choline transporter (BCCT) family; unknown function YP_003044969.1 similar to b1802 YP_003044970.1 similar to b1803 YP_003044971.1 similar to b1804 YP_003044972.1 Activates fatty acids by binding to coenzyme A YP_003044973.1 similar to b1806 YP_003044974.1 similar to b1807 YP_003044975.1 similar to b1808 YP_003044976.1 similar to b1809 YP_003044977.1 similar to b1810 YP_003044978.1 similar to b1811 YP_003044979.1 similar to b1812 YP_003044980.1 similar to b1813 YP_003044981.1 similar to b1814 YP_003044982.1 similar to b1815 YP_003044983.1 similar to b1816 YP_003044984.1 similar to b1817 YP_003044985.1 similar to b1818 YP_003044986.1 hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel YP_003044987.1 similar to b1820 YP_003044988.1 membrane protein YebN YP_003044989.1 methylates the guanosine in position 745 of 23S rRNA; required for translation and cell growth YP_003044990.1 similar to b1823 YP_003044991.1 similar to b1824 YP_003044992.1 similar to b1825 YP_003044993.1 similar to b1826 YP_003044994.1 similar to b4536 YP_003044995.1 similar to b1827 YP_003044996.1 similar to b1828 YP_003044997.1 putative metalloprotease YP_003044998.1 Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3 YP_003044999.1 affects solute and DNA transport through an unknown mechanism YP_003045000.1 similar to b1832 YP_003045001.1 similar to b1833 YP_003045002.1 similar to b1834 YP_003045003.1 in Escherichia coli this enzyme specifically methylates C1407 of the 16S rRNA YP_003045004.1 similar to b1836 YP_003045005.1 similar to b1837 YP_003045006.1 Plays a key role in signaling protein misfolding via the cpxR/cpxA transducing system; modulates the phosphorylated status of many phosphoproteins YP_003045007.1 similar to b1839 YP_003045008.1 similar to b1840 YP_003045009.1 similar to b1841 YP_003045010.1 similar to b1842 YP_003045011.1 similar to b1843 YP_003045012.1 3'-5' exonuclease activity on single or double-strand DNA YP_003045013.1 PtrB; oligopeptidase that cleaves peptide bonds following arginine and lysine residues YP_003045014.1 similar to b1846 YP_003045015.1 secreted protein; unknown function YP_003045016.1 similar to b1848 YP_003045017.1 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis YP_003045018.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate YP_003045019.1 catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate YP_003045020.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_003045021.1 Represses the expression of the zwf, eda, glp and gap YP_003045022.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_003045023.1 Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA YP_003045024.1 similar to b1856 YP_003045025.1 involved in transport of zinc(II) with ZnuA and C YP_003045026.1 involved in transport of zinc(II) with ZnuA and C YP_003045027.1 involved in transport of zinc(II) with ZnuA and C YP_003045028.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_003045029.1 plays an essential role in ATP-dependent branch migration of the Holliday junction YP_003045030.1 similar to b1862 YP_003045031.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity YP_003045032.1 similar to b1864 YP_003045033.1 converts dATP to dAMP and pyrophosphate YP_003045034.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_003045035.1 similar to b1867 YP_003045036.1 similar to b1868 YP_003045037.1 similar to b1869 YP_003045038.1 similar to b1870 YP_003045039.1 similar to b1871 YP_003045040.1 similar to b1872 YP_003045041.1 similar to b1873 YP_003045042.1 similar to b1874 YP_003045043.1 similar to b1875 YP_003045044.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_003045045.1 similar to b1877 YP_003045046.1 similar to b1878 YP_003045047.1 membrane protein involved in the flagellar export apparatus YP_003045048.1 membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export YP_003045049.1 cytosolic phosphatase which functions in the chemotaxis signal transduction complex by controlling the level of phosphorylated CheY through dephosphorylation YP_003045050.1 chemotaxis regulator that, when phosphorylated, interacts with the flagellar motor causing the flagella to spin clockwise which causes the cell to tumble YP_003045051.1 regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins YP_003045052.1 methylates the MCP YP_003045053.1 mediates taxis toward dipeptides YP_003045054.1 similar to b1886 YP_003045055.1 similar to b1887 YP_003045056.1 chemotactic sensory histidine kinase in two-component regulatory system with CheB and CheY; sensory histidine kinase/signal sensing protein; CheA is the histidine kinase component YP_003045057.1 with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine YP_003045058.1 With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine YP_003045059.1 With FlhD is involved in the activation of class 2 flagellar genes and as well as a number of other genetic systems YP_003045060.1 with FlhC is involved in the activation of class 2 flagellar genes and is involved in the regulation of a number of other genetic systems YP_003045061.1 ppGpp-dependent; membrane-associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress YP_003045062.1 similar to b1896 YP_003045063.1 biosynthetic; catalyzes the formation of trehalose and phosphate from trehalose-6-phosphate; expression is increased under osmotic stress and induced during the transition to stationary phase and by decreased temperature YP_003045064.1 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose YP_003045065.1 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose YP_003045066.1 similar to b1901 YP_003045067.1 similar to b1902 YP_003045068.1 similar to b4537 YP_003045069.1 similar to b1904 YP_003045070.1 cytoplasmic iron storage protein YP_003045071.1 similar to b1906 YP_003045072.1 similar to b1907 YP_003045073.1 similar to b1908 YP_003045074.1 similar to b1912 YP_003045075.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_003045076.1 similar to b1914 YP_003045079.1 Hsp31 stabilizes early unfolding protein intermediates under severe heat stress YP_003045080.1 similar to b1968 YP_003045081.1 induced by CusR in the presence of copper; YedW induces the expression of the upstream gene yedV (encoding a sensor kinase) as well as yedW; yedVW is one of four copper regulons found in E. coli; part of the copper homeostasis mechanism; confers resistance to copper and several drugs when induced YP_003045082.1 similar to b1970 YP_003045083.1 in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ YP_003045084.1 in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme YP_003045085.1 similar to b1973 YP_003045086.1 similar to b1974 YP_003045087.1 similar to b1976 YP_003045088.1 similar to b1978 YP_003045089.1 similar to b1981 YP_003045090.1 Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile YP_003045091.1 similar to b1983 YP_003045092.1 similar to b1985 YP_003045093.1 LysR-type transcriptional regulator similar to CysB; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates two operons consisting of ABC transporters that are part of the cys regulon; regulated by CysB YP_003045094.1 Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation YP_003045095.1 similar to b1990 YP_003045096.1 catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole YP_003045097.1 catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole YP_003045098.1 catalyzes ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphate and the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP YP_003045099.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats YP_003045104.1 similar to b2007 YP_003045105.1 similar to b2008 YP_003045106.1 similar to b2009 YP_003045107.1 removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; penicillin-binding protein 6B; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains YP_003045108.1 Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates YP_003045109.1 similar to b2012 YP_003045110.1 similar to b2013 YP_003045111.1 similar to b2014 YP_003045112.1 similar to b2015 YP_003045113.1 similar to b2016 YP_003045115.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors YP_003045116.1 similar to b2020 YP_003045117.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_003045118.1 catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate YP_003045119.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide YP_003045120.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide YP_003045121.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase YP_003045122.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis YP_003045123.1 similar to b2027 YP_003045124.1 similar to b2028 YP_003045125.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate YP_003045135.1 involved in dTDP-N-acetylviosamine synthesis YP_003045136.1 involved in dTDP-N-acetylviosamine synthesis YP_003045139.1 similar to b2039 YP_003045140.1 with dTDP-4-dehydrorhamnose 3,5-epimerase forms a complex known as dTDP-L-rhamnose synthetase; catalyzes the reduction of dTDP-4-dehydro-6-deoxy-L-mannose to dTDP-L-rhamnose YP_003045141.1 NAD(P) binding; catalyzes the formation of dTDP-4-dehydro-6-deoxy-D-glucose from dTDP-glucose YP_003045142.1 together with GalU subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose YP_003045143.1 WcaM from Salmonella enterica is essential for biofilm formation on HEp-2 cells and chicken intestinal tissue but not on a plastic surface; may be involved in the biosynthesis of colanic acid YP_003045144.1 similar to b2044 YP_003045145.1 similar to b2045 YP_003045146.1 similar to b2046 YP_003045147.1 WcaJ; glucose-1-phosphate transferase responsible for the addition of the first glucose-1-phosphate from UDP-glucose to the lipid carrier undecaprenyl phosphate in the biosynthesis of colanic acid YP_003045148.1 similar to b2048 YP_003045149.1 similar to b2049 YP_003045150.1 similar to b2050 YP_003045151.1 similar to b2051 YP_003045152.1 similar to b2052 YP_003045153.1 similar to b2053 YP_003045154.1 acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit) YP_003045155.1 similar to b2055 YP_003045156.1 essential for colanic acid biosynthesis; colanic acid is an exopolysaccharide produced under stress conditions that confers acid and heat tolerance YP_003045157.1 similar to b2057 YP_003045158.1 acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); wcaB is induced in sessile bacteria and by osmotic shock, and repressed when grown in rich medium YP_003045159.1 similar to b2059 YP_003045160.1 Wzc; catalyzes the autophosphorylation on tyrosine residues which downregulates the biosynthesis of colonic acid (an extracellular polysaccharide) YP_003045161.1 Wzb shows phosphatase activity towards the autophosphorylated Wzc protein, which induces colanic acid biosynthesis; catalyzes the phosphorylation of UDP-glucose dehydrogenase, an enzyme involved in colanic acid biosynthesis YP_003045162.1 similar to b2062 YP_003045163.1 similar to b2063 YP_003045164.1 YegA; inner membrane protein involved in the assembly of outer membrane proteins (OMPs); asmA-null mutants show low lipopolysaccharide (LPS) levels, suggesting a role in LPS biogenesis and/or in restricting outer membrane fluidity, resulting on altered assembly of OMPs YP_003045165.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis YP_003045166.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor YP_003045167.1 contains a MASE1 (Membrane-Associated Sensor) domain; potentially involved in signal transduction YP_003045168.1 inducible, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine YP_003045169.1 similar to b2069 YP_003045170.1 similar to b2070 YP_003045171.1 similar to b2072 YP_003045172.1 similar to b2073 YP_003045173.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate YP_003045174.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate YP_003045175.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC; confers resistance against novobiocin and deoxycholate YP_003045176.1 similar to b2077 YP_003045177.1 similar to b2078 YP_003045178.1 response regulator in two-component regulatory system with BaeS; regulator of RNA synthesis, flagellar biosynthesis, chemotaxis and transport YP_003045179.1 similar to b2080 YP_003045180.1 similar to b2081 YP_003045181.1 in E. coli K-12 this is in prophage P2 remnant YP_003045182.1 similar to b2083; pseudo in K-12 MG1655 YP_003045208.1 similar to b2085 YP_003045209.1 cytosolic protein with phosphatidylglycerol kinase activity; undetermined physiological role YP_003045210.1 similar to b2089-b2090(b4498); interrupted by IS3 in K-12 MG1655 YP_003045211.1 Zn-dependent; NAD(P)-binding; catalyzes the formation of tagatose-6-phosphate from galactitol-1-phosphate YP_003045212.1 similar to b2092 YP_003045213.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_003045214.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_003045217.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway YP_003045218.1 catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate YP_003045219.1 similar to b2098 YP_003045220.1 similar to b2099 YP_003045221.1 similar to b2100 YP_003045222.1 similar to b2101 YP_003045223.1 similar to b2102 YP_003045224.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine YP_003045225.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP YP_003045235.1 similar to b2112 YP_003045236.1 similar to b2113 YP_003045237.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content YP_003045238.1 similar to b2115-b2116-21174(b4499) YP_003045239.1 similar to b2118 YP_003045240.1 similar to b4541 YP_003045241.1 similar to b2119 YP_003045242.1 similar to b2120 YP_003045243.1 similar to b2121 YP_003045244.1 similar to b2122 YP_003045245.1 similar to b2123 YP_003045246.1 similar to b2124 YP_003045247.1 unknown function; when overproduced it confers drug-resistance YP_003045248.1 similar to b2126 YP_003045249.1 similar to b2127 YP_003045250.1 similar to b4542 YP_003045251.1 similar to b2128 YP_003045252.1 similar to b2129 YP_003045253.1 similar to b2130 YP_003045254.1 similar to b2131 YP_003045255.1 similar to b2132 YP_003045256.1 component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent YP_003045257.1 specifically hydrolyze the DD-diaminopimelate-alanine bonds in high-molecular-mass murein sacculi; Penicillin-binding protein 7 YP_003045258.1 similar to b2135 YP_003045259.1 similar to b2136 YP_003045260.1 similar to b2137 YP_003045261.1 may be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride YP_003045262.1 similar to b2140 YP_003045263.1 similar to b2141 YP_003045264.1 similar to b2142 YP_003045265.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis YP_003045266.1 similar to b2144 YP_003045267.1 similar to b2145 YP_003045268.1 function undetermined; similar to glutamate synthase beta subunit and related oxidoreductases which transfer electrons from NADPH to an acceptor protein or protein domain YP_003045269.1 catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines YP_003045270.1 ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex YP_003045271.1 with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains YP_003045272.1 similar to b2150 YP_003045273.1 negative regulator of the mglBAC operon for galactose utilization YP_003045274.1 similar to b2152 YP_003045275.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer YP_003045276.1 similar to b2154 YP_003045277.1 Cir; FeuA; CirA; receptor protein for siderophores (colicin IA, IB and V) and microcins (E492, H47, and M); TonB-dependent; able to transport monomers, dimer, and linear trimers of 2,3-dihydorxybenzoylserine; outer membrane protein YP_003045278.1 similar to b2156 YP_003045279.1 similar to b2157 YP_003045280.1 similar to b2158 YP_003045281.1 Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues YP_003045282.1 similar to b2160 YP_003045283.1 similar to b2161 YP_003045284.1 Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively YP_003045285.1 activator of nucleoside metabolism YP_003045286.1 similar to b2164 YP_003045287.1 similar to b2165 YP_003045288.1 similar to b2166 YP_003045289.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_003045290.1 converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers YP_003045291.1 phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr YP_003045292.1 similar to b2170 YP_003045293.1 similar to b4502 YP_003045294.1 Stimulates the peptidyltransferase activity of the 70S ribosome and enhances dipeptide synthesis with N-formylmethionyl-tRNA and puromycin in vitro, suggesting its involvement in the formation of the first peptide bond of a protein YP_003045295.1 similar to b2172 YP_003045296.1 similar to b2173 YP_003045297.1 similar to b2174 YP_003045298.1 by similarity, Spr seems to have peptidase activity; involved in thermoresistance YP_003045299.1 similar to b2176 YP_003045300.1 similar to b2177 YP_003045301.1 similar to b2178 YP_003045302.1 similar to b2179 YP_003045303.1 similar to b2180 YP_003045304.1 similar to b2181 YP_003045305.1 Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance YP_003045306.1 catalyzes the synthesis pseudouridine from uracil-516 in 16S ribosomal RNA YP_003045307.1 similar to b2184 YP_003045308.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response YP_003045309.1 similar to b2186 YP_003045310.1 similar to b2187 YP_003045311.1 similar to b2188 YP_003045312.1 similar to b2190 YP_003045313.1 nitrate/nitrite response regulator NarP; NarP is phosphorylated by NarX and NarQ and can activate fdnG and nitrite or nitrate reductase systems; represses expression of other anaerobic genes YP_003045314.1 similar to b2194 YP_003045315.1 similar to b2195 YP_003045316.1 similar to b2196 YP_003045317.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane YP_003045318.1 similar to b2198 YP_003045319.1 similar to b2199 YP_003045320.1 similar to b2200 YP_003045321.1 ATP-binding protein; required for proper cytochrome c maturation YP_003045322.1 with NapABDFGH functions as a nitrate reductase; NapC functions as an electron shuttle between NapAB and NapGH or quinone YP_003045323.1 small subunit of periplasmic nitrate reductase; receives electrons from the membrane-bound NapC and passes them to NapA YP_003045324.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA YP_003045325.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway YP_003045326.1 periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC YP_003045327.1 similar to b2207 YP_003045328.1 Predicted role in electron transfer to the periplasmic nitrate reductase protein NapA. YP_003045329.1 serine protease inhibitor, inhibits trypsin and other proteases YP_003045330.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate YP_003045331.1 efflux pump for the antibacterial peptide microcin J25 YP_003045332.1 similar to b2212 YP_003045333.1 similar to b2213 YP_003045334.1 catalyzes the conversion of aminoimidazole ribotide to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine moiety of thiamine; involved in the maintenance and/or assembly of sulfur clusters; periplasmic lipoporotein anchored to the inner membrane; part of the thiamine pyrophosphate biosynthesis pathway YP_003045335.1 similar to b2215 YP_003045338.1 similar to b2218 YP_003045339.1 with AtoC is a member of a two-component regulatory system involved in the transcriptional regulation of the ato genes for acetoacetate metabolism YP_003045340.1 with AtoS is a two-component regulatory system involved in the transcriptional regulation of the ato genes for acetoacetate metabolism YP_003045341.1 similar to b2221 YP_003045342.1 similar to b2222 YP_003045343.1 similar to b2223 YP_003045344.1 similar to b2224 YP_003045345.1 similar to b2225 YP_003045346.1 similar to b2226 YP_003045347.1 similar to b2227-b2228(b4500); pseudo in K-12 MG1655 YP_003045348.1 similar to b2229 YP_003045349.1 similar to b2230 YP_003045350.1 negatively supercoils closed circular double-stranded DNA YP_003045351.1 Involved in ubiquinone biosynthesis YP_003045352.1 similar to b2233 YP_003045353.1 Catalyzes the rate-limiting step in dNTP synthesis YP_003045354.1 B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA YP_003045355.1 plays a role in maintenance and possibly the biosynthesis of diferric-tyrosyl radical cofactor, essential for nucleotide reduction catalyzed by ribonucleotide reductases YP_003045356.1 similar to b2237 YP_003045357.1 similar to b2238 YP_003045358.1 hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic YP_003045359.1 catalyzes the uptake of glycerol-3-phosphate into the cell with the simultaneous export of inorganic phosphate from the cell YP_003045360.1 anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor YP_003045361.1 sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters YP_003045362.1 anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate YP_003045363.1 similar to b2244 YP_003045364.1 similar to b2245 YP_003045365.1 similar to b2246 YP_003045366.1 similar to b2247 YP_003045367.1 similar to b2248 YP_003045368.1 similar to b2249 YP_003045369.1 similar to b2250 YP_003045370.1 similar to b2251 YP_003045371.1 similar to b2252 YP_003045372.1 catalyzes the conversion of UDP-4-keto-arabinose to UDP-4-amino-4-deoxy-L-arabinose YP_003045373.1 catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate YP_003045374.1 Bifunctional polymyxin resistance arnA protein; catalyzes the decarboxylation of UDP-glucuronic acid to UDP-4-keto-arabinose and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose to form UDP-L-4-formamido-arabinose; active in certain mutant strains YP_003045375.1 similar to b2256 YP_003045376.1 catalyzes the addition of 4-amino-4-deoxy-L-arabinose to lipid A YP_003045377.1 similar to b4544 YP_003045378.1 similar to b2258 YP_003045379.1 similar to b2259 YP_003045380.1 similar to b2260 YP_003045381.1 catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate YP_003045382.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA YP_003045383.1 catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA YP_003045384.1 SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis YP_003045385.1 similar to b2265 YP_003045386.1 similar to b2266 YP_003045387.1 similar to b2267 YP_003045388.1 member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions YP_003045389.1 ElaD; specific cysteine protease which targets ubiquitin and ubiquitin-like proteins covalently bound to target proteins; SseL in Salmonella is required for macrophage killing and virulence, and it is secreted by the salmonella pathogenicity island 2 type III secretion system YP_003045390.1 similar to b2272 YP_003045393.1 Catalyzes the transfer of electrons from NADH to quinone YP_003045394.1 Catalyzes the transfer of electrons from NADH to quinone YP_003045395.1 Catalyzes the transfer of electrons from NADH to ubiquinone YP_003045396.1 Catalyzes the transfer of electrons from NADH to quinone YP_003045397.1 Catalyzes the transfer of electrons from NADH to quinone YP_003045398.1 Catalyzes the transfer of electrons from NADH to quinone YP_003045399.1 Catalyzes the transfer of electrons from NADH to quinone YP_003045400.1 Catalyzes the transfer of electrons from NADH to quinone YP_003045401.1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase YP_003045402.1 Catalyzes the transfer of electrons from NADH to quinone YP_003045403.1 NuoCD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunits NuoCD, E, F, and G constitute the peripheral sector of the complex; in Escherichia coli this gene encodes a fusion protein of NuoC and NuoD that are found separate in other organisms YP_003045404.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen YP_003045405.1 Catalyzes the transfer of electrons from NADH to quinone YP_003045406.1 DNA-binding transcriptional repressor of flagellar, motility and chemotaxis genes; similar to b2289 YP_003045407.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor YP_003045408.1 similar to b2291 YP_003045409.1 similar to b2292 YP_003045410.1 similar to b2293 YP_003045411.1 similar to b2294 YP_003045412.1 similar to b2295 YP_003045413.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA YP_003045414.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate YP_003045415.1 similar to b2298 YP_003045416.1 similar to b2299 YP_003045417.1 similar to b2300 YP_003045418.1 similar to b2301 YP_003045419.1 similar to b2302 YP_003045420.1 catalyzes the formation of dihydromonapterin triphosphate from dihydroneopterin triphosphate YP_003045421.1 similar to b2304 YP_003045422.1 similar to b2305 YP_003045423.1 similar to b2306 YP_003045424.1 similar to b2307 YP_003045425.1 similar to b2308 YP_003045426.1 similar to b2309 YP_003045427.1 similar to b2310 YP_003045428.1 catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate YP_003045429.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway YP_003045430.1 membrane protein required for colicin V production YP_003045431.1 similar to b2314 YP_003045432.1 similar to b2315 YP_003045433.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits YP_003045434.1 similar to b2317 YP_003045435.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability YP_003045436.1 similar to b2319 YP_003045437.1 similar to b2320 YP_003045438.1 in Salmonella typhimurium Flk regulates flagellar biosynthesis by inhibition of the flagellar-associated type III secretion system; lowers secretion levels of the anti-sigma28 factor FlgM to the periplasm; inner membrane-anchored protein YP_003045439.1 similar to b2322 YP_003045440.1 FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_003045441.1 catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules YP_003045442.1 similar to b2325 YP_003045443.1 similar to b2326 YP_003045444.1 similar to b2327 YP_003045445.1 D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm YP_003045446.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis YP_003045447.1 involved in methylation of ribosomal protein L3 YP_003045448.1 similar to b2331 YP_003045449.1 similar to b2332 YP_003045450.1 similar to b2333 YP_003045451.1 similar to b2334 YP_003045452.1 similar to b2335 YP_003045453.1 similar to b2336 YP_003045454.1 similar to b2337-b2338 YP_003045455.1 similar to b2339 YP_003045456.1 similar to b2340 YP_003045457.1 multifunctional enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities: forms a heterotetramer with FadI; similar to FadA2B2 complex; involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate YP_003045458.1 FadI; fatty acid oxidation complex component beta; functions in a heterotetramer with FadJ; similar to FadA2B2 complex; functions in beta-oxidation of fatty acids during anaerobic growth YP_003045459.1 similar to b2343 YP_003045460.1 similar to b2344 YP_003045463.1 similar to b2346 YP_003045464.1 similar to b2347 YP_003045465.1 regulates the synthesis and expression of the dsdXA operon and dadA gene YP_003045466.1 member of the Gnt family of gluconate transporters; not involved in gluconate transport; unknown function YP_003045467.1 catalyzes the formation of pyruvate from serine YP_003045468.1 similar to b2367 YP_003045469.1 similar to b2368 YP_003045470.1 response regulator in two-component regulatory system with EvgS; phosphorylated EvgA activates ompC, emrKY, gadABC, hdeAB and others genes; involved in acid resistance, osmotic adaption, and drug resistance YP_003045471.1 similar to b2370 YP_003045472.1 similar to b2371 YP_003045473.1 member of the AEC family of auxin efflux transporters; unknown function YP_003045474.1 catalyzes the formation of formyl-CoA from oxalyl-CoA YP_003045475.1 catalyzes the formation of oxalyl-CoA from oxalate and Formyl-CoA YP_003045476.1 similar to b2375 YP_003045477.1 similar to b2376 YP_003045478.1 similar to b2377 YP_003045479.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(palmitoleoyl)-lipid IVA in cells subjected to cold shock YP_003045480.1 similar to b2379 YP_003045481.1 similar to b2380 YP_003045482.1 similar to b2381 YP_003045483.1 similar to b2382 YP_003045484.1 similar to b2383 YP_003045485.1 metalloprotein YP_003045486.1 Xaa-Pro aminopeptidase; limited methionine aminopeptidase YP_003045487.1 similar to b2386 YP_003045488.1 similar to b2387 YP_003045489.1 catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate YP_003045490.1 similar to b2389 YP_003045491.1 similar to b2390 YP_003045492.1 similar to b2392 YP_003045493.1 similar to b2393 YP_003045494.1 similar to b2395 YP_003045495.1 similar to b2398 YP_003045496.1 similar to b2399 YP_003045497.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_003045499.1 similar to b2409 YP_003045500.1 similar to b2410 YP_003045501.1 similar to b4546 YP_003045502.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB YP_003045503.1 interacts with cell division protein FitsZ and may be required to anchor septal ring structure YP_003045504.1 putative role in sulfur assimilation YP_003045505.1 CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis YP_003045506.1 similar to b2415 YP_003045507.1 Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system YP_003045508.1 functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose YP_003045509.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal YP_003045510.1 similar to b2419 YP_003045511.1 similar to b2420 YP_003045512.1 catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide YP_003045513.1 similar to b2422 YP_003045514.1 similar to b2423 YP_003045515.1 similar to b2424 YP_003045516.1 similar to b2425 YP_003045517.1 similar to b2426 YP_003045518.1 similar to b2427 YP_003045519.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway YP_003045520.1 belongs to PEP-dependent PTS system; contains the PTS EIIBC domains; involved in uptake of exogenous N-acetylmuramic acid (MurNAc); requires crr-encoded enzyme IIA-glucose component YP_003045521.1 similar to b2430 YP_003045522.1 similar to b2431 YP_003045523.1 similar to b2432 YP_003045524.1 similar to b2433 YP_003045525.1 similar to b2434 YP_003045526.1 similar to b2435 YP_003045527.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis YP_003045528.1 activates the transcription of the ethanolamine utilization operon YP_003045529.1 similar to b2438 YP_003045530.1 similar to b2439 YP_003045531.1 catalyzes the formation of acetaldehyde from ethanolamine YP_003045532.1 similar to b2441 YP_003045533.1 ethanolamine utilization protein EutA YP_003045534.1 similar to b2452 YP_003045535.1 similar to b2453 YP_003045536.1 similar to b2454 YP_003045537.1 similar to b2455 YP_003045538.1 similar to b2456 YP_003045539.1 similar to b2457 YP_003045540.1 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta YP_003045541.1 similar to b2459 YP_003045542.1 similar to b2460 YP_003045543.1 similar to b2461 YP_003045544.1 similar to b2462 YP_003045545.1 NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate YP_003045546.1 similar to b2464 YP_003045547.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase YP_003045548.1 similar to b2466 YP_003045549.1 similar to b2467 YP_003045550.1 unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic) YP_003045551.1 similar to b2469 YP_003045552.1 similar to b2470 YP_003045553.1 similar to b2471 YP_003045554.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica. YP_003045555.1 similar to b4547 YP_003045556.1 Displays esterase activity toward palmitoyl-CoA and pNP-butyrate YP_003045557.1 similar to b2474 YP_003045558.1 similar to b2475 YP_003045559.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_003045560.1 similar to b2477 YP_003045561.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis YP_003045562.1 negative transcriptional regulator of the gcvTHP operon YP_003045563.1 bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine YP_003045564.1 similar to b2481 YP_003045565.1 similar to b2482 YP_003045566.1 similar to b2484 YP_003045567.1 interacts with formate dehydrogenase to produce an active formate hydrogenlyase complex which cleaves formate to dihydrogen and carbon dioxide YP_003045568.1 similar to b2486 YP_003045569.1 similar to b2487 YP_003045570.1 probable electron transfer protein for hydrogenase 4; hydrogenase 4 is believed to be silent in E. coli under conditions tested so far YP_003045571.1 similar to b2489 YP_003045572.1 similar to b2490 YP_003045573.1 similar to b2491 YP_003045574.1 inner membrane protein presumed to act as a formate transporter; member of the hyf operon YP_003045575.1 similar to b2493 YP_003045576.1 similar to b2494 YP_003045577.1 similar to b2495 YP_003045578.1 controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP YP_003045579.1 similar to b2497 YP_003045580.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate YP_003045581.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis YP_003045582.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate YP_003045583.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate YP_003045584.1 similar to b2502 YP_003045585.1 similar to b2503 YP_003045586.1 similar to b2504 YP_003045587.1 similar to b2505 YP_003045588.1 similar to b2506 YP_003045589.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_003045590.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate YP_003045591.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides YP_003045592.1 similar to b2510 YP_003045593.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_003045594.1 with YaeT, YfiO, and NlpB forms a complex involved in outer membrane protein biogenesis YP_003045595.1 similar to b2513 YP_003045596.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG YP_003045597.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis YP_003045598.1 similar to b2516 YP_003045599.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance YP_003045600.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate YP_003045601.1 penicillin-insensitive transglycosylase/transpeptidase YP_003045602.1 similar to b2520 YP_003045603.1 catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds YP_003045604.1 enhances serine sensitivity caused by inhibition of homoserine dehydrogenase I YP_003045605.1 catalyzes the removal of an N-terminal amino acid from a peptide or arylamide YP_003045606.1 similar to b2524 YP_003045607.1 similar to b2525 YP_003045608.1 involved in the maturation of iron-sulfur cluster-containing proteins YP_003045609.1 J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins YP_003045610.1 forms iron-sulfur clusters of ferredoxin [2FE-2S]; binds iron in the presence of the thioredoxin reductase system; forms homodimers and tetramers; similar to SufA protein YP_003045611.1 similar to b2529 YP_003045612.1 catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis YP_003045613.1 regulates the expression of the iscRSUA operon YP_003045614.1 similar to b2532 YP_003045615.1 similar to b2533 YP_003045616.1 similar to b2534 YP_003045617.1 similar to b2535 YP_003045618.1 putative transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters YP_003045619.1 activator of 3-phenylpropionic acid catabolism YP_003045620.1 similar to b2538 YP_003045621.1 similar to b2539 YP_003045622.1 similar to b2540 YP_003045623.1 Converts cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol) into 3-(2,3-dihydroxylphenyl)propionate YP_003045624.1 similar to b2542 YP_003045625.1 similar to b2543 YP_003045626.1 similar to b2544 YP_003045627.1 similar to b2545 YP_003045628.1 similar to b2546 YP_003045629.1 similar to b2547 YP_003045630.1 similar to b2548 YP_003045631.1 similar to b2549 YP_003045632.1 similar to b2550 YP_003045633.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_003045634.1 flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine YP_003045635.1 indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA YP_003045636.1 similar to b2554 YP_003045637.1 similar to b2555 YP_003045638.1 similar to b2556 YP_003045639.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_003045642.1 similar to b2559 YP_003045643.1 similar to b2560 YP_003045644.1 similar to b2561 YP_003045645.1 similar to b2562 YP_003045646.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids YP_003045647.1 involved in the de novo synthesis of pyridoxine (Vitamin B6) YP_003045648.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA YP_003045649.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_003045650.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity YP_003045651.1 catalyzes the cleavage of the amino-terminal leader peptide from secretory proteins YP_003045652.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_003045653.1 involved in the reduction of the SoxR iron-sulfur cluster YP_003045654.1 periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP YP_003045655.1 similar to b2572 YP_003045656.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response YP_003045657.1 catalyzes the formation of oxaloacetate from L-aspartate YP_003045658.1 similar to b2575 YP_003045659.1 facilitates an early step in the assembly of the 50S subunit of the ribosome YP_003045660.1 similar to b2577 YP_003045661.1 similar to b2578 YP_003045662.1 stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit YP_003045663.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine YP_003045664.1 similar to b2581 YP_003045665.1 similar to b2582 YP_003045666.1 similar to b2583 YP_003045667.1 similar to b2584 YP_003045668.1 catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome YP_003045669.1 similar to b2586 YP_003045670.1 similar to b2587 YP_003045671.1 similar to b2592 YP_003045672.1 similar to b2593 YP_003045673.1 responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA YP_003045674.1 with YaeT, NlpB and YfgL forms a complex involved in the proper assembly and/or targeting of OMPs to the outer membrane; involved in resistance to ampicillin and tetracycline YP_003045675.1 associated with 30S ribosomal subunit; interferes with translation elongation YP_003045677.1 catalyzing the formation of prephenate from chorismate and the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis YP_003045678.1 catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis YP_003045679.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive YP_003045680.1 similar to b2602 YP_003045681.1 similar to b2603 YP_003045682.1 similar to b2604 YP_003045683.1 similar to b2605 YP_003045684.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_003045685.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA YP_003045686.1 Essential for efficient processing of 16S rRNA YP_003045687.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_003045688.1 with 4.5S RNA forms a signal recognition particle involved in targeting and integration of inner membrane proteins YP_003045689.1 similar to b2611 YP_003045690.1 similar to b4461 YP_003045691.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor YP_003045692.1 catalyzes the phosphorylation of NAD to NADP YP_003045693.1 similar to b2616 YP_003045694.1 similar to b2617 YP_003045695.1 similar to b2618 YP_003045696.1 similar to b2619 YP_003045697.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_003045704.1 in Escherichia coli this gene is induced by carbon starvation and depends on sigma S and cAMP-CRP; the structure of the Gab protein shows it is a member of non-heme iron (II)-dependent oxygenase superfamily which includes clavamini acid synthases; forms homotetramers in solution YP_003045705.1 catalyzed the formation of 2-ketoglutarate from 2-hydroxyglutarate YP_003045706.1 catalyzes the formation of succinate from succinate semialdehyde; NADP dependent YP_003045707.1 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate YP_003045708.1 similar to b2663 YP_003045709.1 regulator of gab gene expression YP_003045710.1 similar to b2665 YP_003045711.1 similar to b2666 YP_003045712.1 similar to b2667 YP_003045713.1 similar to b2668 YP_003045714.1 similar to b2669 YP_003045715.1 similar to b2670 YP_003045716.1 similar to b2671 YP_003045717.1 similar to b2672 YP_003045718.1 similar to b2673 YP_003045719.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF YP_003045720.1 Catalyzes the rate-limiting step in dNTP synthesis YP_003045721.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE YP_003045722.1 with ProWX is involved in the high-affinity uptake of glycine betaine YP_003045723.1 with ProVX is involved in the high-affinity uptake of glycine betaine YP_003045724.1 with ProVW, part of the high-affinity transport system for the osmoprotectant glycine betaine YP_003045725.1 similar to b2680-b2681 YP_003045726.1 similar to b2682 YP_003045727.1 similar to b2683 YP_003045728.1 DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux; negative regulator of the multidrug operon emrAB YP_003045729.1 similar to b2685 YP_003045730.1 similar to b2686 YP_003045731.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2 YP_003045732.1 involved in the first step of glutathione biosynthesis YP_003045733.1 similar to b2689 YP_003045734.1 YqaB; catalyzes the dephosphorylation of fructose 1-phosphate, 6-phosphogluconate and p-nitrophenyl phosphate (pNPP); presents beta-phosphoglucomutase activity at a lower extent YP_003045735.1 affects carbohydrate metabolism; has regulatory role in many processes YP_003045736.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_003045737.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities YP_003045738.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs YP_003045739.1 similar to b2700 YP_003045740.1 membrane-bound lytic murein transglycosylase B; catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan YP_003045741.1 similar to b2702 YP_003045742.1 similar to b2703 YP_003045743.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_003045744.1 catalyzes the conversion of sorbitol 6-phosphate into fructose 6-phosphate YP_003045745.1 regulator for glucitol utilization YP_003045746.1 regulates genes involved in glucitol utilization YP_003045747.1 catalyzes the conversion of D-arabinose 5-phosphate to D-ribulose-5-phosphate YP_003045748.1 Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon YP_003045749.1 detoxifies nitric oxide using NADH YP_003045750.1 catalyzes the reduction of the rubredoxin moiety of nitric oxide reductase YP_003045751.1 carbamoyl phosphate phosphatase and maturation protein for [NiFe] hydrogenases; similar to b2712 YP_003045752.1 involved in electron transport from formate to hydrogen YP_003045753.1 similar to b2714 YP_003045754.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_003045755.1 similar to b2716 YP_003045756.1 involved in processing C-terminal end of HycE; involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE YP_003045757.1 similar to b2718; protein required for maturation of hydrogenase 3 YP_003045758.1 similar to b2719 YP_003045759.1 electron transfer protein for hydrogenase-3; the formate hydrogenlyase complex comprises of a formate dehydrogenase, unidentified electron carriers and hydrogenase-3; in this non-energy conserving pathway, molecular hydrogen and carbodioxide are released from formate YP_003045760.1 similar to b2721 YP_003045761.1 similar to b2722 YP_003045762.1 catalyzes the oxidation of formate to carbon dioxide and molecular hydrogen; formate hydrogenlyase comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (subunit 3) YP_003045763.1 similar to b2724 YP_003045764.1 regulates several genes involved in the formate hydrogenlyase system; seems to prevent binding of FhlA transcriptional activator to the activator sequence of hyc operon YP_003045765.1 plays a role in hydrogenase nickel cofactor insertion YP_003045766.1 GTP hydrolase involved in nickel liganding into hydrogenases YP_003045767.1 HypC; accessory protein necessary for maturation of the hydrogenase isoforms 1, 2 and 3; forms a complex with HypD, HypE, and HypF proteins, which is the site of ligand biosynthesis and attachment to the iron atom of the NiFe site in the hydrogenase YP_003045768.1 similar to b2729; protein required for maturation of hydrogenase isozymes YP_003045769.1 similar to b2730 YP_003045770.1 similar to b2731 YP_003045771.1 similar to b2732 YP_003045772.1 This protein performs the mismatch recognition step during the DNA repair process YP_003045773.1 similar to b2734 YP_003045774.1 similar to b2735 YP_003045775.1 similar to b2736 YP_003045776.1 similar to b2737 YP_003045777.1 similar to b2738 YP_003045778.1 similar to b2739 YP_003045779.1 member of the Gnt family of gluconate transporters; not involved in gluconate transport; unknown function YP_003045780.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor controls a regulon of genes required for protection against external stresses YP_003045781.1 outer membrane lipoprotein involved in stationary-phase cell survival; similar to LppB virulence determinant from Haemophilus somnus YP_003045782.1 catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins YP_003045783.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate YP_003045784.1 catalyzes the modification of U13 in tRNA(Glu) YP_003045785.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate YP_003045786.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers YP_003045787.1 forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein YP_003045788.1 similar to b2749 YP_003045789.1 converts ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis YP_003045790.1 may be GTPase that regulates ATP sulfurylase activity that is involved in converting ATP and sulfate to diphosphate and adenylylsulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis in the first step; forms a heterodimer with CysD; part of the GTP-binding elongation factor family CysN/NodQ YP_003045791.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP YP_003045792.1 catalyzes the sequential removal of 2 amino-terminal arginines from alkaline phosphatase isozyme 1 to form isozymes 2 and 3 YP_003045796.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite YP_003045797.1 hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide YP_003045798.1 catalyzes the reduction of sulfite to sulfide in the biosynthesis of L-cysteine from sulfate; a flavoprotein with flavin reductase activity YP_003045799.1 similar to b2765 YP_003045800.1 similar to b2766 YP_003045801.1 similar to b2767 YP_003045802.1 similar to b2768 YP_003045803.1 similar to b2769 YP_003045804.1 similar to b2770 YP_003045805.1 similar to b2771 YP_003045806.1 similar to b4463 YP_003045807.1 similar to b2774 YP_003045808.1 similar to b2775 YP_003045809.1 similar to b2776 YP_003045811.1 similar to b2777 YP_003045812.1 similar to b2778 YP_003045813.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_003045814.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_003045815.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era YP_003045816.1 MazF; endoribonuclease; toxin of the ChpA-ChpR toxin-antitoxin system YP_003045817.1 part of the MazF-MazE toxin-antitoxin system; conteracts MazF YP_003045818.1 (p)ppGpp synthetase; catalyzes the formation of pppGpp and ppGpp from ATP and GTP or GDP YP_003045819.1 in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S] YP_003045820.1 part of the two-component regulatory system with UvrY; involved in the regulation of carbon metabolism via the csrA/csrB regulatory system YP_003045821.1 similar to b2787 YP_003045822.1 similar to b2788 YP_003045823.1 similar to b2789 YP_003045824.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_003045825.1 catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp YP_003045826.1 similar to b2792 YP_003045827.1 putative SecY regulator that either chelates excess SecY or negatively regulates the SecYE translocase function YP_003045828.1 catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis YP_003045829.1 similar to b2795 YP_003045830.1 similar to b2796 YP_003045831.1 similar to b2797 YP_003045832.1 has 3'-5' exonuclease activity that preferentially acts on ssDNA; also 3'-phosphodiesterase activity at sites with 3' incised apurinic/apyrimidinic sites; can remove 3' phosphoglycolate groups YP_003045833.1 similar to b2799 YP_003045841.1 catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose YP_003045842.1 similar to b2803 YP_003045843.1 similar to b2804 YP_003045844.1 regulates expression of genes involved in L-fucose utilization YP_003045845.1 similar to b2806 YP_003045846.1 similar to b2807 YP_003045847.1 Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence YP_003045848.1 similar to b2809 YP_003045849.1 similar to b2810 YP_003045850.1 similar to b2811 YP_003045851.1 similar to b2812 YP_003045852.1 membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues YP_003045853.1 similar to b2817 YP_003045854.1 catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis YP_003045855.1 helicase/nuclease; with RecBC catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity YP_003045856.1 helicase/nuclease; with RecCD catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity YP_003045857.1 similar to b2821 YP_003045858.1 catalyzes ATP-dependent exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides; component of the RecBCD (Exo V) helicase/nuclease complex that is essential for recombination YP_003045859.1 similar to b2823 YP_003045860.1 similar to b2824 YP_003045861.1 similar to b2825 YP_003045862.1 similar to b2826 YP_003045863.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived YP_003045864.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein YP_003045865.1 member of a second PTS chain involved in nitrogen metabolism; PtsP phosphorylates NPr YP_003045866.1 hydrolyzes diadenosine polyphosphate YP_003045867.1 MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair YP_003045868.1 similar to b2832 YP_003045869.1 similar to b2833 YP_003045870.1 complements the prephenate dehydrogenase dysfunction of an Escherichia coli tyrosine auxotroph strain; member of the aldo/keto reductase 2 family; crystal structure of purified Escherichia coli protein shows bound NADPH YP_003045871.1 similar to b2835 YP_003045872.1 Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1 YP_003045873.1 controls transcription of galETKM YP_003045874.1 catalyzes the decarboxylation of diaminopimelate into lysine; pyridoxal phosphate(PLP)-binding YP_003045875.1 activates the transcription of the lysA gene encoding diaminopimelate decarboxylase YP_003045876.1 similar to b2840 YP_003045877.1 similar to b2841 YP_003045878.1 catalyzes the formation of 3-dehydro-2-deoxy-D-gluconate from 2-deoxy-D-gluconate YP_003045879.1 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; catalyzes the interconversion of 4-deoxy-L-threo-5-hexosulose uronate to 3-deoxy-D-glycero-2,5-hexodiulosonate YP_003045880.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis YP_003045881.1 similar to b2845 YP_003045882.1 similar to b2846 YP_003045885.1 similar to b2863 YP_003045886.1 similar to b2865 YP_003045887.1 putative molybdenum cofactor-binding protein; participates in purine salvage YP_003045888.1 FAD-binding subunit; with XdhA and XdhC participates in purine salvage YP_003045889.1 iron-sulfur-binding subunit; with XdhA and XdhB participates in purine salvage YP_003045890.1 similar to b2869 YP_003045891.1 similar to b2870 YP_003045892.1 catalyzes the formation of pyruvate from 2,3-diaminopropionate YP_003045893.1 Zn-dependent extracellular dipeptidase; similar to succinyl-diaminopimelate desuccinylases YP_003045894.1 catalyzes the hydrolytic cleavage of hydantoin with aromatic side chains at the 5'position YP_003045895.1 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP YP_003045896.1 similar to b2875 YP_003045897.1 similar to b2876 YP_003045898.1 similar to b2877 YP_003045899.1 with YgfM and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfK mutants are unable to reduce selenate; involved in purine salvage process; seems to act as an oxidoreductase, but sequence similarity suggests it is a dihydrothymine dehydrogenase YP_003045900.1 in Escherichia coli expression is induced in response to phase-specific signals and controlled by RpoS YP_003045901.1 with YgfK and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfM contains a FAD domain YP_003045902.1 with YgfK and YgfM forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; molybdopterin-containing enzyme; oxidase activity toward hypoxanthine and xanthine can be detected if these substrates are present at high concentration YP_003045903.1 similar to b2882 YP_003045904.1 Catalyzes the deamination of guanine YP_003045905.1 similar to b4464 YP_003045906.1 similar to b2886 YP_003045907.1 unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic) YP_003045908.1 similar to b2888 YP_003045909.1 catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate YP_003045910.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 YP_003045911.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1 YP_003045912.1 5'-3' single-stranded-DNA-specific exonuclease YP_003045913.1 DsbC; periplasmic protein with protein disulfide isomerase activity; this protein also shows disulfide oxidoreductase activity YP_003045914.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_003045915.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic YP_003045916.1 similar to b2896 YP_003045917.1 similar to b2897 YP_003045918.1 physiological role is not clear; not essential for growth but mutants grow poorly; mutations suppress hda null mutations; may be involved in regulation of ATP-DnaA levels; may also be involved in regulation of tRNA modifications; can bind folic acid and tetrahydrofolate; forms a three domain ring-like structure with a central channel; structurally similar to DMGO protein from A. globiformis; shows sequence similarity to yeast CAF17 transcriptional regulator YP_003045919.1 similar to b2899 YP_003045920.1 similar to b2900 YP_003045921.1 similar to b2901 YP_003045922.1 similar to b2902 YP_003045923.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine YP_003045924.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor YP_003045925.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein YP_003045926.1 similar to b2906 YP_003045927.1 Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone YP_003045928.1 exopeptidase able to cleave the peptide bond of the last amino acid if linked to a proline residue; substrate can be as short as a dipeptide YP_003045929.1 the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown YP_003045930.1 similar to b2910 YP_003045931.1 ygfA expression increases five to eight fold in Escherichia coli cells growing as biofilms; unknown function YP_003045932.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate YP_003045933.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway YP_003045934.1 similar to b2915 YP_003045935.1 specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport YP_003045936.1 MDM; functions in conversion of succinate to propionate YP_003045937.1 functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins YP_003045938.1 catalyzes the formation of propanoyl-CoA from methylmalonyl-CoA YP_003045939.1 similar to b2920 YP_003045940.1 similar to b2921 YP_003045941.1 similar to b2922 YP_003045942.1 Involved in the export of arginine YP_003045943.1 participates in the regulation of osmotic pressure changes within the cel YP_003045944.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate YP_003045945.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_003045946.1 NAD-dependent; catalyzes the formation of 4-phosphoerythronate from erythrose 4-phosphate in the biosynthesis of pyridoxine 5'-phosphate YP_003045947.1 similar to b2928 YP_003045948.1 similar to b2929 YP_003045949.1 similar to b2930 YP_003045950.1 similar to b4465 YP_003045951.1 similar to b2933 YP_003045952.1 TolM; with CmtA (IIBC), CmtB possibly forms the mannitol-like permease component of the cryptic mannitol phosphotransferase system, which phosphorylates and transports various carbohydrates and polyhydric alcohols in Escherichia coli; cytoplasmic protein YP_003045953.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase YP_003045954.1 similar to b2936 YP_003045955.1 catalyzes the formation of putrescine from agmatine YP_003045956.1 catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis YP_003045957.1 similar to b2939 YP_003045958.1 similar to b2940 YP_003045959.1 similar to b2941 YP_003045960.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_003045961.1 similar to b2943 YP_003045962.1 similar to b2944 YP_003045963.1 similar to b2945 YP_003045964.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_003045965.1 catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione YP_003045966.1 similar to b2948 YP_003045967.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function YP_003045968.1 similar to b2950 YP_003045969.1 similar to b2951 YP_003045970.1 similar to b2952 YP_003045971.1 similar to b2953 YP_003045972.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine YP_003045973.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_003045974.1 similar to b2956 YP_003045975.1 catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis YP_003045976.1 similar to b2958 YP_003045977.1 similar to b2959 YP_003045978.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine YP_003045979.1 similar to b2961 YP_003045980.1 similar to b2962 YP_003045981.1 Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues YP_003045982.1 similar to b2964 YP_003045983.1 similar to b2965 YP_003045984.1 similar to b2966 YP_003045987.1 similar to b2000 YP_003045988.1 similar to b2001 YP_003045990.1 similar to b0252 YP_003045992.1 similar to b2002 YP_003045993.1 similar to b2003 YP_003045994.1 similar to b2004 YP_003045995.1 similar to b2005 YP_003045996.1 similar to b2006 YP_003046004.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS YP_003046016.1 similar to b2968 YP_003046025.1 part of the general (type II) secretion pathway (GSP), a signal sequence-dependent process responsible for protein export; involved in trans-location of exoproteins from the cytoplasm to the periplasm YP_003046026.1 similar to b2971 YP_003046027.1 similar to b2972 YP_003046028.1 similar to b4466 YP_003046029.1 similar to b2975 YP_003046030.1 catalyzes the formation of malate from glyoxylate and acetyl-CoA YP_003046031.1 similar to b2977 YP_003046032.1 similar to b4467 YP_003046033.1 similar to b4468 YP_003046034.1 similar to b2979 YP_003046035.1 similar to b2980 YP_003046036.1 similar to b2981 YP_003046037.1 activates fatty acids by binding to coenzyme A YP_003046045.1 similar to b2983 YP_003046046.1 similar to b2984 YP_003046047.1 similar to b2985 YP_003046048.1 similar to b2986 YP_003046049.1 similar to b2987 YP_003046050.1 catalyzes the formation of glutathionylspermidine from glutathione and spermidine; also catalyzes the reverse reaction YP_003046051.1 YghU; B2989; one of eight putative glutathione transferase proteins from E. coli YP_003046052.1 similar to b2990 YP_003046053.1 plays a role in hydrogenase nickel cofactor insertion YP_003046054.1 similar to b2992 YP_003046055.1 protease responsible for the cleavage of a 15 amino acid peptide from the C-terminal end of the large subunit of hydrogenase 2 (HybC) YP_003046056.1 involved in hydrogen uptake YP_003046057.1 HybB; cytochrome b subunit of the hydrogenase 2 enzyme, composed of HybA, B, C, and O subunits YP_003046058.1 Fe-S ferrodoxin type component; participates in the periplasmic electron-transferring activity of hydrogenase 2 YP_003046059.1 similar to b2998 YP_003046060.1 similar to b2999-b3000 YP_003046061.1 similar to b3001 YP_003046062.1 similar to b3002 YP_003046063.1 similar to b3003 YP_003046064.1 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell YP_003046065.1 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell YP_003046066.1 catalyzes the formation of L-homocysteine from cystathionine YP_003046067.1 similar to b3009 YP_003046068.1 similar to b3010 YP_003046069.1 similar to b3011 YP_003046070.1 methylglyoxal reductase/#-keto ester reductase; catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; also catalyzes the reduction of methylglyoxal, ethyl-2-methylacetoacetate and ethyl-acetoacetate YP_003046071.1 similar to b3013 YP_003046072.1 similar to b3014 YP_003046073.1 similar to b4469 YP_003046074.1 similar to b3017 YP_003046075.1 similar to b3018 YP_003046076.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_003046077.1 YgiS; uncharacterized periplasmic protein that seems to be part of a binding-protein-dependent transport system YP_003046078.1 similar to b3021 YP_003046079.1 similar to b3022 YP_003046080.1 similar to b3023 YP_003046081.1 similar to b3024 YP_003046082.1 response regulator in two-component regulatory system with QseC; regulates FlhCD which is the master regulator for flagella and motility genes YP_003046083.1 similar to b3026 YP_003046084.1 similar to b3027 YP_003046085.1 similar to b3028 YP_003046086.1 similar to b3029 YP_003046087.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_003046088.1 Displays esterase activity toward palmitoyl-CoA and pNP-butyrate YP_003046089.1 similar to b3032 YP_003046090.1 similar to b3033 YP_003046091.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose YP_003046092.1 trimeric outer membrane protein involved in efflux of hydrophobic/amphipathic molecules; functions with a number of efflux systems in the inner membrane to transport molecules out of the cell YP_003046093.1 similar to b3036 YP_003046094.1 similar to b3037 YP_003046095.1 similar to b3038 YP_003046096.1 seems to be involved in biofilm formation; in asymptomatic bacteriuria E. coli strains 83972 and VR50, the ygiD gene is upregulated during biofilm formation in urine YP_003046097.1 similar to b3040 YP_003046098.1 DHBP synthase; functions during riboflavin biosynthesis YP_003046099.1 similar to b3042 YP_003046100.1 similar to b3043 YP_003046101.1 similar to b3046 YP_003046102.1 similar to b3047 YP_003046103.1 similar to b3048 YP_003046104.1 Involved in glycogen synthesis. May be involved in glycogen priming YP_003046105.1 similar to b3050 YP_003046106.1 similar to b3051 YP_003046107.1 catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose YP_003046108.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme YP_003046109.1 similar to b3054 YP_003046110.1 similar to b3055 YP_003046111.1 catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases YP_003046112.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell YP_003046113.1 catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin and can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin YP_003046114.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX YP_003046115.1 activates expression of genes required for L-tartrate-dependent anaerobic growth on glycerol YP_003046116.1 Involved in the tartrate degradation pathway YP_003046117.1 Involved in the tartrate degradation pathway YP_003046118.1 similar to b3063 YP_003046119.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity YP_003046120.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA YP_003046121.1 synthesizes RNA primers at the replication forks YP_003046122.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria YP_003046123.1 similar to b3068 YP_003046124.1 similar to b3070 YP_003046125.1 similar to b3071 YP_003046126.1 similar to b3072 YP_003046127.1 catalyzes the formation of 4-aminobutyraldehyde from putrescine and 2-oxoglutarate YP_003046128.1 similar to b3074 YP_003046129.1 similar to b3075 YP_003046130.1 in Escherichia coli this is the second beta-galactosidase system YP_003046131.1 in Escherichia coli this is the second beta-galactosidase system YP_003046132.1 similar to b3078 YP_003046133.1 similar to b3079 YP_003046134.1 similar to b3080 YP_003046135.1 similar to b3081 YP_003046136.1 similar to b3082 YP_003046137.1 similar to b3083 YP_003046138.1 similar to b3084 YP_003046139.1 similar to b3085 YP_003046140.1 similar to b3086 YP_003046141.1 similar to b3087 YP_003046142.1 similar to b3088 YP_003046143.1 involved in the import of serine and threonine coupled with the import of sodium YP_003046144.1 similar to b3090 YP_003046145.1 similar to b3091 YP_003046146.1 catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism YP_003046147.1 similar to b3093 YP_003046148.1 regulates the exuT, uxaCA and uxuRAB operons which encode genes involved in hexuronate utilization. YP_003046149.1 similar to b3095 YP_003046150.1 similar to b3096 YP_003046151.1 similar to b3097 YP_003046152.1 similar to b3098 YP_003046153.1 similar to b3099 YP_003046154.1 similar to b3100 YP_003046155.1 similar to b3101 YP_003046156.1 similar to b3102 YP_003046157.1 similar to b3103 YP_003046158.1 similar to b3104 YP_003046159.1 similar to b3105 YP_003046160.1 similar to b3106 YP_003046161.1 similar to b3107 YP_003046162.1 similar to b4470 YP_003046163.1 similar to b3110 YP_003046164.1 similar to b4471 YP_003046165.1 similar to b3113 YP_003046166.1 similar to b3114 YP_003046167.1 catalyzes the formation of propanoyl phosphate from propanoate and ATP; TdcD also has acetate kinase activities and functions in anaerobic threonine catabolism YP_003046168.1 involved in the import of threonine and serine in combination with the import of a proton YP_003046169.1 catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic YP_003046170.1 regulates the tdcABCDEFG operon which is involved in amino acid degradation YP_003046171.1 participates in controlling the expression of several structural genes for the enzyme threonine dehydratase; TdcR activates the tdcABCDEFG operon YP_003046172.1 similar to b3120 YP_003046173.1 similar to b3121 YP_003046174.1 similar to b3124 YP_003046175.1 catalyzes the reduction of tartronate semialdehyde to glycerate YP_003046176.1 cleaves 5-dehydro-4-deoxy-glucarate and 2-dehydro-3-deoxy-D-glucarate YP_003046177.1 similar to b3127 YP_003046178.1 similar to b3128 YP_003046179.1 SohA; PrlF; involved in protein secretion; when overproduced or mutated, it induces growth defect and increased export of a reporter protein; a PrlF mutation induces the activity of the Lon protease, and a Lon-deficient strain suppresses the phenotype conferred by the PrlF mutation YP_003046180.1 similar to b3130 YP_003046181.1 transcriptional repressor for the agaZVWA and agaSYBCDI operons YP_003046182.1 similar to b3132 YP_003046183.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake;involved in N-acetylgalactosamine transport YP_003046184.1 similar to b3134 YP_003046187.1 similar to b3135 YP_003046188.1 similar to b3136 YP_003046189.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway YP_003046190.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; involved in N-acetylgalactosamine transport YP_003046191.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane;protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; involved in N-acetylgalactosamine transport YP_003046192.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N-acetylgalactosamine transport YP_003046193.1 similar to b3141 YP_003046194.1 similar to b3142 YP_003046195.1 similar to b3143 YP_003046196.1 similar to b3144 YP_003046197.1 similar to b3145 YP_003046198.1 similar to b3146 YP_003046199.1 similar to b3147 YP_003046200.1 similar to b3148 YP_003046201.1 Required for the timely initiation of chromosomal replication via direct interactions with the dnaA initiator protein YP_003046202.1 similar to b3150 YP_003046203.1 similar to b3151 YP_003046204.1 similar to b3152 YP_003046205.1 similar to b3153 YP_003046206.1 similar to b3154 YP_003046207.1 similar to b3155 YP_003046208.1 similar to b3156 YP_003046209.1 similar to b3157 YP_003046210.1 similar to b3158 YP_003046211.1 similar to b3159 YP_003046212.1 similar to b3160 YP_003046213.1 tryptophan transporter of high affinity YP_003046214.1 participates in the assembly of the large subunit of the ribosome; plays a key role in optimal cell growth at low temperature and is required for normal cell division YP_003046215.1 lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing YP_003046216.1 similar to b3164 YP_003046217.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence YP_003046218.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs YP_003046219.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock YP_003046220.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_003046221.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_003046222.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins YP_003046223.1 catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis YP_003046224.1 similar to b3173 YP_003046225.1 similar to b3175 YP_003046226.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate YP_003046227.1 catalyzes the formation of dihydropteroate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate YP_003046228.1 inner membrane metalloprotease; may be involved in degradation of aberrant cytoplasmic and membrane proteins YP_003046229.1 Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit YP_003046230.1 RNA binding protein found associated to pre-50S subunit of the ribosome; putative role in ribosome assembly; necessary for optimal growth but not cell viability YP_003046231.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_003046232.1 penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains YP_003046233.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_003046234.1 similar to b3184 YP_003046235.1 involved in the peptidyltransferase reaction during translation YP_003046236.1 similar to b3186 YP_003046237.1 similar to b3187 YP_003046238.1 activator of maltose metabolism genes YP_003046239.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_003046240.1 similar to b3190 YP_003046241.1 similar to b3191 YP_003046242.1 similar to b3192 YP_003046243.1 similar to b3193 YP_003046244.1 similar to b3194 YP_003046245.1 ATP-binding subunit of a putative ABC toluene efflux transporter YP_003046246.1 YrbG; inner membrane protein involved in cell envelope integrity; putative sodium ion/calcium ion exchanger; in E. coli it is non essential for cell viability; member of the YRBG family of cation/Ca2+ exchangers YP_003046247.1 similar to b3197 YP_003046248.1 forms homotetramers; catalyzes hydrolysis of KDO 8-P to KDO and inorganic phosphate; functions in lipopolysaccharide biosynthesis YP_003046249.1 similar to b3199 YP_003046250.1 LptA; periplasmic binding protein part of a putative ABC superfamily of uptake transporters; interacts with LptB protein, the ATP binding component of the uptake system YP_003046251.1 similar to b3201 YP_003046252.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen YP_003046253.1 YhbH; resting ribosome-binding protein involved in ribosome stabilization and preservation in stationary phase; binds specifically 100S ribosomes (an inactive ribosome product of a 70S ribosome dimerization); seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing YP_003046254.1 similar to b3204 YP_003046255.1 similar to b3205 YP_003046256.1 similar to b3206 YP_003046257.1 similar to b3207 YP_003046258.1 glycosyltransferase; polymerizes glycan strands in the peptidoglycan YP_003046259.1 similar to b3209 YP_003046260.1 sensor-regulator protein which regulates the expression of many genes in response to respiratory growth conditions including anaerobic repression of the arc modulon; hybrid sensory histidine kinase in two-component regulatory system with ArcA YP_003046261.1 similar to b3211 YP_003046262.1 catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate YP_003046263.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate YP_003046264.1 similar to b3220 YP_003046266.1 similar to b3221 YP_003046267.1 catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein YP_003046268.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate YP_003046269.1 similar to b3224 YP_003046270.1 catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid YP_003046271.1 Transcriptional repressor of the nan operon that encodes proteins involved in sialic acid utilization YP_003046272.1 YhcL; uncharacterized member of the DcuC family of anaerobic dicarboxylate transporters; probable role in transport of carboxylates across the inner membrane from the periplasm; its encoding gene is not essential for growth and is probably cryptic YP_003046273.1 similar to b3228 YP_003046274.1 transcriptional activator; required for activation of bacteriophage P1 late promoter; induced by starvation YP_003046275.1 forms a direct contact with the tRNA during translation YP_003046276.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_003046277.1 similar to b3232 YP_003046278.1 similar to b3233 YP_003046279.1 similar to b3234 YP_003046280.1 similar to b3235 YP_003046281.1 oxidizes malate to oxaloacetate YP_003046282.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes YP_003046283.1 similar to b3238 YP_003046284.1 similar to b3239 YP_003046285.1 with AaeA forms an efflux pump whose substrates are p-hydroxybenzoic acid 6-hydroxy-2-naphthoic and 2-hydroxycinnamate YP_003046286.1 with AaeB forms an efflux pump whose substrates are p-hydroxybenzoic acid, 6-hydroxy-2-naphthoic and 2-hydroxycinnamate YP_003046287.1 membrane protein AaeX; the gene is a member of the aaeXAB operon YP_003046288.1 similar to b3243 YP_003046289.1 responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase; degrades the E. coli plasmid F-encoded CcdA YP_003046290.1 similar to b4472 YP_003046291.1 involved in the processing of the 5'end of 16S rRNA YP_003046292.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell YP_003046293.1 part of cell wall structural complex MreBCD; transmembrane component YP_003046294.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall YP_003046295.1 functions in MreBCD complex in some organisms YP_003046296.1 regulates the degradation of the small RNAs CsrB and CsrC; may function to targate RNase E to specific RNA molecules YP_003046297.1 similar to b3253 YP_003046298.1 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_003046299.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_003046300.1 similar to b3257 YP_003046301.1 mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase YP_003046302.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype YP_003046303.1 similar to b3260 YP_003046304.1 Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription YP_003046305.1 similar to b3262 YP_003046306.1 similar to b3263 YP_003046307.1 similar to b3264 YP_003046308.1 similar to b3265 YP_003046309.1 similar to b3266 YP_003046310.1 similar to b3267 YP_003046311.1 similar to b3268 YP_003046312.1 similar to b3269 YP_003046313.1 similar to b3270 YP_003046314.1 similar to b3271 YP_003046315.1 similar to b3279 YP_003046316.1 similar to b3280 YP_003046317.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate YP_003046318.1 RimN; YrdC; required for maturation of 16s RNA; binds preferentially double stranded RNA YP_003046319.1 similar to b3283 YP_003046320.1 similar to b3284 YP_003046321.1 similar to b4473 YP_003046322.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_003046323.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth YP_003046324.1 catalyzes the methylation of cytosine at position 967 (m5C967) of 16S rRNA; SAM-dependent methyltransferase YP_003046325.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain YP_003046326.1 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock YP_003046327.1 similar to b4550 YP_003046328.1 mediates expression of the zinc export protein ZntA in response to high levels of zinc; member of MerR family of transcriptional regulators YP_003046329.1 similar to b3293 YP_003046330.1 is a component of the macrolide binding site in the peptidyl transferase center YP_003046331.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_003046332.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_003046333.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_003046334.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA YP_003046335.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif YP_003046336.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_003046337.1 late assembly protein YP_003046338.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 YP_003046339.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_003046340.1 binds 5S rRNA along with protein L5 and L25 YP_003046341.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_003046342.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_003046343.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif YP_003046344.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_003046345.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_003046346.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase YP_003046347.1 primary binding protein; helps mediate assembly; involved in translation fidelity YP_003046348.1 one of the stabilizing components for the large ribosomal subunit YP_003046349.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_003046350.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_003046351.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_003046352.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_003046353.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_003046354.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_003046355.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_003046356.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_003046357.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex YP_003046358.1 calcium-binding protein that may be required for the initiation of chromosome replication YP_003046359.1 similar to b3323 YP_003046360.1 similar to b3324 YP_003046361.1 similar to b3325 YP_003046362.1 similar to b3326 YP_003046363.1 similar to b3327 YP_003046364.1 similar to b3328 YP_003046365.1 similar to b3329 YP_003046366.1 similar to b3330 YP_003046367.1 similar to b3331 YP_003046368.1 similar to b3332 YP_003046369.1 similar to b3333 YP_003046370.1 similar to b3334 YP_003046371.1 similar to b3335 YP_003046372.1 iron storage protein YP_003046373.1 similar to b3337 YP_003046374.1 similar to b3338 YP_003046375.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_003046376.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_003046377.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_003046378.1 similar to b3342 YP_003046379.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs YP_003046380.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs YP_003046381.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs YP_003046382.1 similar to b3346 YP_003046383.1 rotamase YP_003046384.1 similar to b3348 YP_003046385.1 rotamase YP_003046386.1 involved in potassium efflux YP_003046387.1 required for KefB activity YP_003046388.1 similar to b3352 YP_003046389.1 similar to b3353 YP_003046390.1 similar to b3354 YP_003046391.1 similar to b3355 YP_003046392.1 similar to b3356 YP_003046393.1 complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons YP_003046394.1 similar to b3358 YP_003046395.1 DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate YP_003046396.1 aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity YP_003046397.1 similar to b3361 YP_003046398.1 similar to b3362 YP_003046399.1 similar to b3363 YP_003046400.1 similar to b3364 YP_003046401.1 similar to b3365 YP_003046402.1 involved in reducing nitrite to ammonium to detoxify nitrite accumulation in anaerobic nitrate-respiring cells and regenerate NAD+; bounds to NirB, the cytoplasmic subunit, whose expression is induced at high nitrate concentrations YP_003046403.1 member of the FNT family of formate and nitrite transporters YP_003046404.1 multifunction enzyme consisting of uroporphyrin-III C-methyltransferase, precorrin-2 dehydrogenase and sirohydrochlorin ferrochelatase; catalyzes the methylation of uroporphyrinogen III to form precorrin-2, then catalyzes formation of sirohydrochlorin from precorrin-2 and finally catalyzed the formation of siroheme from sirohydrochlorin YP_003046405.1 similar to b3369 YP_003046406.1 inner membrane protein possibly involved in fructoselysine transport; member of the flr operon YP_003046407.1 catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine YP_003046408.1 YhfOP; YhfP; YhfO; FrlC; catalyzes the interconversion of fructoselysine and psicoselysine YP_003046409.1 similar to b3374 YP_003046410.1 may act as a transcriptional regulator of a putative fructoselysine-induced operon containing the yhfM, yhfN, yhfO, yhfP, yhfQ, and yhfR genes YP_003046413.1 similar to b3377 YP_003046414.1 similar to b3378 YP_003046415.1 phosphotriesterase homology protein; PhP; YhfV; member of a family of proteins related to phosphotriesterase (PTE) YP_003046416.1 similar to b3380 YP_003046417.1 similar to b3381 YP_003046418.1 similar to b3382 YP_003046419.1 similar to b3383 YP_003046420.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_003046421.1 catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate YP_003046422.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate YP_003046423.1 similar to b3387 YP_003046424.1 similar to b3388 YP_003046425.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis YP_003046426.1 type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis YP_003046427.1 outer membrane porin probably involved in uptake of extracellular double-stranded DNA; similar to outer membrane competence protein ComE from Haemophilus influenzae and outer membrane protein PilQ involved in type IV pilus production from Pseudomonas aeruginosa YP_003046428.1 similar to b3392 YP_003046429.1 similar to b3393 YP_003046430.1 similar to b3394 YP_003046431.1 similar to b3395 YP_003046432.1 bifunctional murein transglycosylase/murein transpeptidase; penicillin-binding protein 1A; involved in the synthesis of cross-linked peptidoglycan from the lipid intermediates in cell wall formation; penicillin-insensitive transglycosylase catalyzes the formation of linear glycan strands and the penicillin-sensitive transpeptidase catalyzes the cross-linking of the peptide subunits YP_003046433.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose YP_003046434.1 similar to b3398 YP_003046435.1 similar to b3399 YP_003046436.1 similar to b3400 YP_003046437.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers YP_003046438.1 similar to b3402 YP_003046439.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP YP_003046440.1 membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR YP_003046441.1 part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation YP_003046442.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_003046443.1 similar to b3407 YP_003046444.1 similar to b3408 YP_003046445.1 cytoplasmic membrane ferrous uptake system permease; mutations disrupt the ability of Escherichia coli to take up ferrous iron; GTP-binding protein which requires GTP for efficient iron(II) uptake YP_003046446.1 similar to b3410 YP_003046447.1 similar to b3411 YP_003046448.1 Shows carboxylesterase activity with a preference for short chain fatty acid esters; involved in pimeloyl-CoA synthesis YP_003046449.1 involved in high-affinity gluconate transport YP_003046450.1 cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source YP_003046451.1 similar to b3415 YP_003046452.1 amylomaltase; acts to release glucose from maltodextrins YP_003046453.1 similar to b3417 YP_003046454.1 Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides YP_003046455.1 catalyzes the conversion of terminal3'-phosphate of RNA to the 2',3'-cyclicphosphodiester YP_003046456.1 similar to b3421 YP_003046457.1 similar to b3422 YP_003046458.1 represses the glpD, glpFK, glpTQ, and glpACB operons involved in glycerol-3-phosphate metabolism YP_003046459.1 protease responsible for the cleavage between Ser and Asp residues of proteins in regions of high local hydrophilicity YP_003046460.1 belongs to rhodanese family; thiosulfate thiotransferase; in Escherichia coli this enzyme catalyzes the formation of thiocyanate from thiosulfate and cyanide with low efficiency; contains an active site cysteine YP_003046461.1 in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane YP_003046463.1 similar to b3428 YP_003046464.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose YP_003046465.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate YP_003046466.1 catalyzes the hydrolysis of the alpha-1,6-glucosidic linkages in partially depolymerized glycogen YP_003046467.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain YP_003046468.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde YP_003046469.1 YhgN; Ec0197; hydrolyzes nucleoside triphosphates with an O6 atom-containing purine base to nucleoside monophosphate and pyrophosphate; seems to play a role in the elimination of aberrant purine-derived nucleotides containing the 6-keto group; shows preference for deoxyinosine triphosphate and xanthosine triphosphate over standard nucleoside triphosphates (dATP, dCTP, dGTP, and dTTP) YP_003046470.1 similar to b4476 YP_003046471.1 thermoresistant; catalyzes the formation of 6-phospho-D-gluconate from gluconate YP_003046472.1 similar to b3438 YP_003046473.1 similar to b3439 YP_003046474.1 similar to b3440 YP_003046475.1 YhhY; regulated by the fur regulator; unknown function YP_003046476.1 similar to b3442 YP_003046477.1 similar to b3443 YP_003046478.1 similar to b3446 YP_003046479.1 periplasmic enzyme; post-translationally processed into two subunits which are required for wild-type enzyme activity; cleaves the gammaglutamyl linkages of compounds such as glutathione and transfer the gammaglutamyl group to other amino acids and peptides YP_003046480.1 similar to b3448 YP_003046481.1 hydrolyzes diesters during transport at the inner face of the cytoplasmic membrane to glycerol-3-phosphate and alcohol; induced when cells are starved for inorganic phosphate YP_003046482.1 part of the UgpABCE glycerol-3-phosphate uptake system YP_003046483.1 with UgpABC is involved in uptake of glycerol-3-phosphate YP_003046484.1 with UgpEC is involved in the uptake of glycerol-3-phosphate YP_003046485.1 with UgpACE is involved in the uptake of glycerol-3-phosphate YP_003046486.1 with LivGHMJ and LivGHMK is part of the high-affinity branched-chain amino acid transport system; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine YP_003046487.1 Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine YP_003046488.1 Part of the ABC transporter complex LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine YP_003046489.1 LivHMGF is the membrane component of the LIV-I/LS branched-chain amino acid transporter YP_003046490.1 similar to b3458 YP_003046491.1 similar to b3459 YP_003046492.1 similar to b3460 YP_003046493.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters YP_003046494.1 putative ABC transporter, membrane protein YP_003046495.1 putative ATP-binding protein of an ATP-binding cassette transporter; when bound to FtsX, FtsEX localizes to the cell division site and plays a role in the assembly or stability of the septal ring under low-salt growth conditions YP_003046496.1 signal recognition protein receptor; functions in the targeting and insertion of membrane proteins YP_003046497.1 catalyzes the methylation of 16S rRNA at position G966 YP_003046498.1 similar to b3466 YP_003046499.1 similar to b3467 YP_003046500.1 similar to b3468 YP_003046501.1 P-type ATPase involved in the export of lead, cadmium, zinc and mercury YP_003046502.1 TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs YP_003046503.1 similar to b3471 YP_003046504.1 similar to b3472 YP_003046505.1 similar to b3473 YP_003046506.1 similar to b3474 YP_003046507.1 similar to b3475 YP_003046508.1 similar to b3476 YP_003046509.1 with NikACDE is involved in nickel transport into the cell YP_003046510.1 with NikABDE is involved in nickel transport into the cell YP_003046511.1 with NikABCE is involved in nickel transport into the cell YP_003046512.1 with NikABCD is involved with nickel transport into the cell YP_003046513.1 Inhibits transcription at high concentrations of nickel YP_003046514.1 similar to b3482 YP_003046515.1 similar to b3483 YP_003046516.1 similar to b3484 YP_003046517.1 similar to b3485 YP_003046518.1 similar to b3486 YP_003046519.1 similar to b3487 YP_003046520.1 similar to b3488 YP_003046521.1 similar to b3489-b3490 YP_003046522.1 similar to b3491 YP_003046523.1 similar to b3492 YP_003046524.1 similar to b3493 YP_003046525.1 ppGpp-dependent, membrane associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress YP_003046526.1 similar to b3495 YP_003046527.1 member of the POT family of peptide transporters; probable proton-dependent peptide transporter function YP_003046528.1 predicted SAM-dependent methyltransferase YP_003046529.1 similar to b3498 YP_003046530.1 similar to b3499 YP_003046531.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense YP_003046532.1 regulates the expression of of the arsRBC involved in resistance to arsenic YP_003046533.1 similar to b3502 YP_003046534.1 similar to b3503 YP_003046535.1 similar to b3504 YP_003046536.1 similar to b3506 YP_003046537.1 similar to b3507 YP_003046538.1 inner membrane protein involved in cell density-dependent acid resistance; part of the acid fitness island (AFI) of E. coli YP_003046539.1 similar to b3509 YP_003046540.1 inactive form YP_003046541.1 similar to b3511 YP_003046542.1 similar to b3512 YP_003046543.1 with MdtF and tolC is involved in resistance to rhodamine 6G, erythromycin, doxorubicin and other compounds YP_003046544.1 similar to b3514 YP_003046545.1 similar to b3515 YP_003046546.1 regulates genes in response to acid and/or during stationary phase YP_003046547.1 similar to b3517 YP_003046548.1 similar to b3518 YP_003046549.1 cytoplasmic; catalyzes the hydrolysis of trehalose to glucose YP_003046550.1 similar to b3520 YP_003046551.1 similar to b3521 YP_003046552.1 similar to b3522 YP_003046553.1 similar to b3523 YP_003046554.1 similar to b3524 YP_003046555.1 in Escherichia coli this protein is involved in flagellar function YP_003046556.1 similar to b3526 YP_003046557.1 similar to b3527 YP_003046558.1 involved in the transport of C4-dicarboxylates across the membrane YP_003046559.1 HmsP in Yersinia pestis plays a role in invasion of epithelial cells; the EAL-domain portion of HmsP from Y. pestis shows phosphodiesterase activity which is required for the inhibition of biofilm formation; inner membrane protein; similar to a putative phosphodiesterase protein from E. coli YP_003046560.1 cellulose is produced by the multicellular morphotypes of E. coli and Salmonella typhimurium; the cellulose biosynthesis genes bcsA, bcsB, bcsZ and bcsC are constitutively transcribed, however, cellulose synthesis is dependent on the expression of adrA YP_003046561.1 catalyzes the hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans YP_003046562.1 binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP) YP_003046563.1 polymerizes uridine 5'-diphosphate glucose to cellulose; acts with BcsB, BcsZ and BcsC in cellulose biosynthesis YP_003046564.1 similar to b3535 YP_003046565.1 similar to b3536 YP_003046566.1 similar to b3537 YP_003046567.1 similar to b3538 YP_003046568.1 similar to b4453 YP_003046569.1 similar to b4453 YP_003046570.1 similar to b4453 YP_003046571.1 similar to b3539 YP_003046572.1 Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides YP_003046573.1 DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF YP_003046574.1 similar to b3542 YP_003046575.1 transports peptides consisting of two or three amino acids YP_003046576.1 similar to b3544 YP_003046577.1 catalyzes the addition of a phosphoethanolamine group to the outer Kdo residue of lipopolysaccharide YP_003046578.1 similar to b3547 YP_003046579.1 similar to b3548 YP_003046580.1 constitutive, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine YP_003046581.1 similar to b3550 YP_003046582.1 similar to b3551 YP_003046583.1 similar to b3552 YP_003046584.1 similar to b3553 YP_003046585.1 similar to b3554 YP_003046586.1 similar to b3555 YP_003046587.1 similar to b3556 YP_003046588.1 similar to b4455 YP_003046591.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_003046592.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_003046593.1 similar to b4553 YP_003046594.1 similar to b3561 YP_003046595.1 similar to b3562 YP_003046596.1 similar to b3563 YP_003046597.1 similar to b3564 YP_003046598.1 catalyzes the interconversion of D-xylose to D-xylulose YP_003046599.1 periplasmic substrate-binding component of the ATP-dependent xylose transport system; high affinity YP_003046600.1 similar to b3568 YP_003046601.1 similar to b3569 YP_003046602.1 similar to b3570 YP_003046603.1 periplasmic enzyme that degrades maltodextrins that enter via the outer membrane porin LamB; hydrolyzes alpha-(1,4) glycosidic linkages; contains internal disulfide bonds YP_003046604.1 transaminase C; catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids; also catalyzes terminal step in valine biosynthesis YP_003046605.1 similar to b3573 YP_003046606.1 similar to b3574 YP_003046607.1 NAD(P)H-dependent; catalyzes the reduction of 2,3-diketo-L-gulonate to 3-keto-L-gulonate YP_003046608.1 similar to b3576 YP_003046609.1 membrane-spanning protein involved in uptake of 2,3-diketo-L-gulonate; part of the tri-partite ATP-independent periplasmic transport system (TRAP) YiaMNO YP_003046610.1 similar to b3578 YP_003046611.1 similar to b3579 YP_003046612.1 similar to b3580 YP_003046613.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate YP_003046614.1 L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate YP_003046615.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source YP_003046619.1 similar to b3584 YP_003046620.1 similar to b3585 YP_003046621.1 similar to b3586 YP_003046622.1 similar to b3587 YP_003046623.1 similar to b3588 YP_003046624.1 similar to b3589 YP_003046625.1 similar to b3590 YP_003046626.1 catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis YP_003046627.1 similar to b3592 YP_003046628.1 similar to b3593 YP_003046629.1 similar to b3594 YP_003046630.1 similar to b3595 YP_003046631.1 similar to b3596 YP_003046632.1 similar to b3597 YP_003046633.1 similar to b3598 YP_003046634.1 similar to b3599 YP_003046635.1 similar to b3600 YP_003046636.1 Acts as a repressor of the mtlAD operon YP_003046637.1 similar to b4554 YP_003046638.1 similar to b3602 YP_003046641.1 similar to b3603 YP_003046642.1 represses the lctPRD operon YP_003046643.1 flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration YP_003046644.1 member of the SPOUT superfamily of RNA methyltransferases; no methyltransferase activity observed with certain tRNA substrates YP_003046645.1 catalyzes the O-acetylation of serine YP_003046646.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate YP_003046647.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA YP_003046648.1 similar to b3610 YP_003046649.1 similar to b3611 YP_003046650.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate YP_003046651.1 similar to b3613 YP_003046652.1 similar to b3614 YP_003046653.1 similar to b3615 YP_003046654.1 converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism YP_003046655.1 catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine YP_003046656.1 catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose YP_003046657.1 catalyzes the transfer of the second heptose to the heptosyl-KDO2 moiety of the lipopolysaccharide inner core YP_003046658.1 similar to b3621 YP_003046666.1 similar to b3630 YP_003046667.1 similar to b3631 YP_003046668.1 similar to b3632 YP_003046669.1 catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A YP_003046670.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA YP_003046671.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases YP_003046672.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif YP_003046673.1 required for 70S ribosome assembly YP_003046674.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase YP_003046675.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine YP_003046676.1 catalyzes the formation of dUMP from dUTP YP_003046677.1 FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly YP_003046678.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate YP_003046679.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs YP_003046680.1 similar to b3644 YP_003046681.1 similar to b3645 YP_003046682.1 similar to b3646 YP_003046683.1 this ligase is similar to LigA but it lacks the C-terminal BRCT domain; catalyzes strand joining of nicked DNA in the presence of a divalent cation and NAD+ YP_003046684.1 Essential for recycling GMP and indirectly, cGMP YP_003046685.1 promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits YP_003046686.1 similar to b3650 YP_003046687.1 specifically modifies tRNA at position G18 YP_003046688.1 catalyzes branch migration in Holliday junction intermediates YP_003046690.1 similar to b3653 YP_003046691.1 similar to b3654 YP_003046692.1 similar to b3655 YP_003046693.1 catalyzes the transfer of alpha-xylosyl residue from alpha-xyloside to xylose, glucose, mannose, fructose, maltose, isomaltose, nigerose, kojibiose, sucrose, and trehalose; shows higher activity against alpha-xylosyl fluoride, isoprimeverose (6-O-alpha-xylopyranosyl-glucopyranose), and alpha-xyloside in xyloglucan oligosaccharides YP_003046694.1 may be involved in the transport of galactosides-pentoses-hexuronides YP_003046712.1 similar to b4505 YP_003046719.1 similar to b3659 YP_003046720.1 similar to b3660 YP_003046721.1 similar to b3661 YP_003046722.1 similar to b4555 YP_003046723.1 experimental results in Escherichia coli suggest that this gene encodes an inosine export protein; member of major facilitator superfamily; MFS YP_003046724.1 similar to b3663 YP_003046725.1 similar to b3664 YP_003046726.1 catalyzes the formation of hypoxanthine from adenine; in E. coli this activity has been detected in mutant strains but not in wild type YP_003046727.1 cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate YP_003046728.1 membrane protein regulates uhpT expression YP_003046729.1 Member of the two-component regulatory system UhpB/UhpA involved in the regulation of the uptake of hexose ph YP_003046730.1 response regulator in two-component regulatory system wtih UhpB; phosphorylated UhpA is a positive activator uhpT, a hexose phosphates transporter YP_003046731.1 with IlvB catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase small subunit YP_003046732.1 similar to b3671 YP_003046733.1 similar to b3672 YP_003046734.1 multidrug efflux protein involved in adaptation to low energy shock YP_003046735.1 similar to b3674 YP_003046736.1 similar to b3675 YP_003046737.1 similar to b3676 YP_003046738.1 similar to b3677 YP_003046739.1 similar to b3678 YP_003046740.1 uncharacterized member of the SSS superfamily of sodium-dependent solute transporters; unknown function YP_003046741.1 similar to b3680 YP_003046742.1 similar to b3681; truncated in K-12 MG1655 YP_003046743.1 similar to b3682-b3683 YP_003046744.1 similar to b3685 YP_003046745.1 16 kDa heat shock protein B; associates with aggregated proteins, together with ibpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; ATP-independent YP_003046746.1 with IbpB associates with aggregated proteins to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress YP_003046747.1 similar to b3688 YP_003046748.1 similar to b3689 YP_003046749.1 FAD/NAD(P)-binding domain YP_003046750.1 similar to b3691 YP_003046751.1 similar to b4478 YP_003046752.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-galactonate 6-phosphate; functions in galactonate metabolism YP_003046753.1 similar to b3693 YP_003046754.1 similar to b4479 YP_003046755.1 similar to b3696 YP_003046756.1 YidA; catalyzes the dephosphorylation of erythrose 4-phosphate (preferred substrate), mannose 1-phosphate and p-nitrophenyl phosphate; hydrolyzes the alpha-D-glucose-1-phosphate but not the beta form; member of the haloacid dehalogenase-like hydrolases superfamily and Cof family of proteins YP_003046757.1 similar to b3698 YP_003046758.1 negatively supercoils closed circular double-stranded DNA YP_003046759.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA YP_003046760.1 binds the polymerase to DNA and acts as a sliding clamp YP_003046761.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. YP_003046762.1 in Escherichia coli transcription of this gene is enhanced by polyamines YP_003046763.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates YP_003046764.1 similar to b4557 YP_003046765.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria YP_003046766.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE YP_003046767.1 similar to b3707 YP_003046768.1 tryptophan indole-lyase; catalyzes the formation of indole and pyruvate from tryptophan YP_003046769.1 tryptophan transporter of low affinity YP_003046770.1 Confers resistance to chloramphenicol YP_003046771.1 Involved in anaerobic NO protection YP_003046772.1 similar to b3712 YP_003046773.1 similar to b3713 YP_003046774.1 similar to b3714 YP_003046775.1 YieH; catalyzes the dephosphorylation of phosphoenolpyruvate, AMP and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; member of the haloacid dehalogenase-like hydrolases superfamily YP_003046776.1 might be involved in hypersensitivity to nitrofurzone YP_003046777.1 similar to b3717 YP_003046778.1 similar to b3718 YP_003046779.1 similar to b3719 YP_003046780.1 similar to b3720 YP_003046781.1 similar to b3721 YP_003046782.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_003046783.1 positive regulator of the beta-glucoside operon; transcriptional antiterminator YP_003046784.1 regulates several genes involved in high affinity phosphate uptake; under conditions of high phosphate concentrations downregulates the PHO regulon YP_003046785.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_003046786.1 Part of the ABC transporter complex PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions YP_003046787.1 part of the ATP-dependent phosphate uptake system PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions YP_003046788.1 similar to b3728 YP_003046789.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source YP_003046790.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis YP_003046791.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane YP_003046792.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_003046793.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit YP_003046794.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_003046795.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex YP_003046796.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel. YP_003046797.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0 YP_003046798.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_003046799.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation YP_003046800.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs YP_003046801.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_003046802.1 transcriptional repressor of asnA which codes for aspartate-ammonia ligase YP_003046803.1 catalyzes the formation of asparagine from aspartate and ammonia YP_003046804.1 contains a von Willibrand factor type A domain; stimulates the ATPase activity of RavA YP_003046805.1 interacts with LdcI, lysine decarboxylase; may be active in late log/ early stationary phase YP_003046806.1 Responsible for the low-affinity transport of potassium into the cell; involved in potassium ion uptake under hyper-osmotic stress at a low pH YP_003046809.1 cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source YP_003046810.1 with RbsBCD acts to import ribose into the cell; RbsA contains 2 ATP-binding domain YP_003046811.1 functions to transport ribose at high affinity; forms a complex with RbsA2C2B YP_003046812.1 periplasmic substrate-binding component of the ATP-dependent ribose transport system YP_003046813.1 catalyzes the formation of D-ribose 5-phosphate from ribose YP_003046814.1 DNA-binding transcriptional repressor of ribose metabolism YP_003046815.1 similar to b3754 YP_003046816.1 similar to b3755 YP_003046817.1 Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon YP_003046818.1 similar to b3764 YP_003046819.1 among the AAA+ ATPases, the YifB protease family belongs to the Helix 2 insert clade; unknown function YP_003046820.1 similar to b3766 YP_003046821.1 catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit YP_003046822.1 similar to b3769 YP_003046823.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids YP_003046824.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis YP_003046825.1 threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway YP_003046826.1 participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate YP_003046827.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis YP_003046828.1 similar to b3775 YP_003046829.1 similar to b3776 YP_003046830.1 single-stranded DNA-dependent ATPase; initiates unwinding at a nick in the DNA; involved in DNA replication YP_003046831.1 catalyzes the conversion of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) to guanosine 5'-diphosphate,3'-diphosphate (ppGpp); pppGpp and ppGpp control the stringent response during amino acid starvation YP_003046832.1 enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation YP_003046833.1 similar to b3781 YP_003046834.1 similar to b3782 YP_003046835.1 similar to b3783 YP_003046836.1 similar to b3784 YP_003046837.1 Enterobacterial Common Antigen (ECA) polysaccharide chain length modulation protein YP_003046838.1 similar to b3786 YP_003046839.1 catalyzes the oxidation of UDP-N-acetyl-D-mannosamine to UDP-N-acetylmannosaminuronic acid YP_003046840.1 similar to b3788 YP_003046841.1 similar to b3789 YP_003046842.1 similar to b3790 YP_003046843.1 catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis YP_003046844.1 similar to b3792 YP_003046845.1 catalyzes the synthesis of a lipid-linked intermediate involved in ECA synthesis YP_003046846.1 enterobacterial common antigen polymerase YP_003046847.1 similar to b3794 YP_003046848.1 uncharacterized member of the amino acid-polyamine-organocation (APC) superfamily of amino acid transporters; unknown function YP_003046849.1 similar to b3800 YP_003046850.1 similar to b3801 YP_003046851.1 similar to b3802 YP_003046852.1 similar to b3803 YP_003046853.1 catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis YP_003046854.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis YP_003046855.1 catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP YP_003046856.1 defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly YP_003046857.1 similar to b3808 YP_003046858.1 similar to b4558 YP_003046859.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate YP_003046860.1 similar to b3810 YP_003046861.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_003046862.1 YigB; member of the haloacid dehalogenase (HAD)-like hydrolases superfamily of protein; unknown function YP_003046863.1 unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair. YP_003046865.1 similar to b4482 YP_003046866.1 responsible for the influx of magnesium ions YP_003046870.1 similar to b3817 YP_003046871.1 similar to b3818 YP_003046872.1 similar to b3819 YP_003046873.1 similar to b3820 YP_003046874.1 catalyzes the hydrolysis of phosphatidylcholine YP_003046875.1 functions in blocking illegitimate recombination, enhancing topoisomerase activity, initiating SOS signaling and clearing blocked replication forks; component of the RecF recombinational pathway YP_003046876.1 similar to b3823 YP_003046877.1 similar to b3824 YP_003046878.1 lecithinase B; catalyzes the conversion of 1-lysophosphatidylcholine to glycerophosphocholine; can also hydrolyze 2-acyl glycerophosphoethanolamine and other substrates YP_003046879.1 purine and pyrimidine nucleotides are secondary substrates; yigL expression is regulated by heat shock, osmotic shock and starvation of glucose, phosphate or ammonium YP_003046880.1 similar to b3827 YP_003046881.1 similar to b3828 YP_003046882.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine YP_003046886.1 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP YP_003046891.1 similar to b3830 YP_003046892.1 catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway YP_003046896.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-galactonate 6-phosphate; functions in galactonate metabolism YP_003046899.1 YigN; nuclease that may cleave DNA structures arising during the recombination of short-inverted repeats and thereby prevents the inversion of the internal sequence; transcription is induced by DNA-damaging agents such as nalidixic acid or mitomycin C in a LexA-dependent manner YP_003046900.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone YP_003046901.1 similar to b3834 YP_003046902.1 an Escherichia coli mutant results in accumulation of octaprenylphenol and no ubiquinone; functions in the formation of 2-octaprenyl-6-hydroxy-phenol from 2-octaprenylphenol in ubiquinone (coenzyme Q) biosynthesis; similar to eukaryotic proteins that exhibit kinase functions YP_003046903.1 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes YP_003046904.1 mediates the export of protein precursors bearing twin-arginine signal peptides YP_003046905.1 with TatABE forms the twin-arginine translocation complex which is involved in the transport of proteins across the cytoplasmic membrane YP_003046906.1 magnesium dependent; not involved in the Sec-independent protein export system YP_003046907.1 similar to b3842 YP_003046908.1 catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol YP_003046909.1 NAD(P)H-flavin reductase; catalyzes the reversible oxidation/reduction of NAD(P) and flavine mononucleotide; in Salmonella and E. coli this protein also reduces aquacob(III)alamin to cob(II)alamin YP_003046910.1 FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids YP_003046911.1 includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids YP_003046912.1 catalyzes the hydrolysis of dipeptides with a proline at the C-terminal; also catalyzes the low efficiency hydrolysis of organophosphate di- and tri-esters YP_003046913.1 similar to b3848 YP_003046914.1 similar to b3849 YP_003046915.1 catalyzes the oxidation of protoporphyrinogen IX to form protoporphyrin IX YP_003046916.1 in Escherichia coli the MobB protein is not essential but has been found to interact with multiple proteins involved in the molybdopterin guanine dinucleotide cofactor biosynthesis pathway YP_003046917.1 in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis YP_003046918.1 similar to b3858 YP_003046919.1 catalyzes the phosphorylation of protein substrates at serine and threonine residues in vitro; specific substrate in vivo has not been identified yet; plays a role in long-term cell survival and expression of surface appendages YP_003046920.1 similar to b3860 YP_003046921.1 similar to b3861 YP_003046922.1 similar to b3862 YP_003046923.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair YP_003046924.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential YP_003046925.1 similar to b3866 YP_003046926.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_003046927.1 response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes; interacts with sigma-54 YP_003046928.1 sensory histidine kinase in two-component regulatory system with GlnG; acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of ntrC by phosphorylation/dephosphorylation YP_003046929.1 forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme YP_003046930.1 similar to b3871 YP_003046931.1 similar to b3872 YP_003046932.1 similar to b3873 YP_003046933.1 similar to b3874 YP_003046934.1 porin involved in the transport of small molecular weight solutes (up to 600 Daltons) across the cell wall; specific substrate still unknown YP_003046935.1 similar to b3876 YP_003046936.1 similar to b3877 YP_003046937.1 similar to b3878 YP_003046938.1 similar to b3879 YP_003046939.1 similar to b3880 YP_003046940.1 similar to b3881 YP_003046941.1 similar to b3882 YP_003046942.1 similar to b3883 YP_003046943.1 similar to b3884 YP_003046944.1 similar to b3885 YP_003046945.1 RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease YP_003046946.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine YP_003046947.1 similar to b3889 YP_003046948.1 similar to b3890 YP_003046949.1 required for the formation of active formate dehydrogenase YP_003046950.1 cytochrome b556(FDO) component; heme containing YP_003046951.1 similar to b3893 YP_003046952.1 similar to b3894; selenocysteine YP_003046953.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth YP_003046954.1 similar to b3896 YP_003046955.1 putative repressor of the frv operon, involved in phosphoenolpyruvate:sugar phosphotransferase system YP_003046956.1 with FrvABR is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system which may be involved in the transport and phosphorylation of sugars YP_003046957.1 similar to b3899 YP_003046958.1 with FrvBRX is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system involved in the transport and phosphorylation of sugars; possibly responsible for the sugar specificity of the system YP_003046960.1 similar to b3901 YP_003046961.1 similar to b3902 YP_003046962.1 catalyzes the formation of L-rhamnulose from L-rhamnose YP_003046963.1 catalyzes the ATP-dependent phosphorylation of rhamnulose YP_003046964.1 activates the expression of the rhaBAD operon and rhaT gene YP_003046965.1 activates the expression of rhaRS in response to L-rhamnose YP_003046966.1 transports L-rhamnose and L-lyxose into the cell YP_003046967.1 SodA; manganese binding; only present under aerobic conditions; destroys free radicals YP_003046968.1 transports degraded pectin products into the bacterial cell YP_003046969.1 similar to b3910 YP_003046970.1 part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors YP_003046971.1 response regulator in two-component regulatory system with CpxA; part of the envelope stress response system YP_003046972.1 repressor of the Cpx envelope stress response pathway which occurs via periplasmic interactions with CpxA; CpxP is degraded by DegP protease especially in the presence of misfolded substrates YP_003046973.1 member of cation diffusion facilitator family; CDF; membrane-bound; induced by both zinc and iron, but does not induce resistance to zinc; can transport zinc(II) in a proton-dependent manner; instead this protein induces iron resistance; forms dimers YP_003046974.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis YP_003046975.1 similar to b3917 YP_003046976.1 similar to b3918 YP_003046977.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate YP_003046978.1 similar to b3920 YP_003046979.1 similar to b3921 YP_003046980.1 similar to b3922 YP_003046981.1 with UspC and Usp E is involved in resistance to UV radiation YP_003046982.1 similar to b3924 YP_003046983.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese YP_003046984.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP YP_003046985.1 similar to b3927 YP_003046986.1 similar to b3928 YP_003046987.1 regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity YP_003046988.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate YP_003046989.1 heat shock protein involved in degradation of misfolded proteins YP_003046990.1 heat shock protein involved in degradation of misfolded proteins YP_003046991.1 similar to b3933 YP_003046992.1 negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins YP_003046993.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity YP_003046994.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_003046996.1 member of the NlpC/P60 superfamily of peptidases YP_003046997.1 when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis YP_003046998.1 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine YP_003046999.1 multifunctional homodimeric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways YP_003047000.1 MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor YP_003047001.1 similar to b3942 YP_003047002.1 similar to b3943 YP_003047003.1 similar to b3944 YP_003047004.1 forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone YP_003047005.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies YP_003047006.1 similar to b3947 YP_003047007.1 FrwC with FrwB, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; forms translocation channel and contains the specific substrate-binding site YP_003047008.1 FrwB with FrwC, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system (PTS) permease which may phosphorylate and transport sugars into the cell; cytoplasmic protein that interacts with complex EIIA; contains the second phosphorylation site of the PTS YP_003047009.1 involved in production of D-lactate from glucose under microaerobic conditions; cytoplasmic protein YP_003047010.1 similar to b3952 YP_003047011.1 FrwD with FrwB, FrwC and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; phosphorylated by EIIA; FrwB homolog YP_003047012.1 similar to b3954 YP_003047013.1 similar to b3955 YP_003047014.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate YP_003047015.1 catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis YP_003047016.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate YP_003047017.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate YP_003047018.1 catalyzes the formation of arginine from (N-L-arginino)succinate YP_003047019.1 Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA YP_003047020.1 catalyzes the conversion of NADPH to NADH YP_003047021.1 negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis YP_003047022.1 similar to b3964 YP_003047023.1 catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs YP_003047024.1 involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space YP_003047025.1 converts L-glutamate to D-glutamate, a component of peptidoglycan YP_003047026.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis YP_003047027.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon YP_003047028.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis YP_003047029.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_003047030.1 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force YP_003047031.1 Modulates Rho-dependent transcription termination YP_003047032.1 binds directly to 23S ribosomal RNA YP_003047033.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_003047034.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_003047035.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors YP_003047036.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_003047037.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_003047038.1 similar to b3989 YP_003047039.1 in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center YP_003047040.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate YP_003047041.1 with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate YP_003047042.1 similar to b3992 YP_003047043.1 catalyzes the formation of thiamine monophosphate from 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate YP_003047044.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine YP_003047045.1 binds specifically to the major sigma factor sigma 70; active in stationary phase YP_003047046.1 can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates YP_003047047.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III YP_003047048.1 Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA; cleaves DNA containing urea residues, AP sites, base mismatches, insertion/deletion mismatches, flaps, and pseudo-Y structures YP_003047049.1 similar to b3999 YP_003047050.1 histone-like DNA-binding protein YP_003047051.1 similar to b4001 YP_003047052.1 similar to b4002 YP_003047053.1 similar to b4003 YP_003047054.1 DNA-binding response regulator in two-component regulatory system with ZraS; response regulator/sigma54 interaction protein YP_003047055.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis YP_003047056.1 involved in de novo purine biosynthesis YP_003047057.1 similar to b4012 YP_003047058.1 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis YP_003047059.1 Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle YP_003047060.1 similar to b4015 YP_003047061.1 catalyzes the phosphorylation/dephosphorylation of the enzyme isocitrate dehydrogenase on a specific serine which regulates activity; unphosphorylated IDH is fully active when cells are grown on glucose while the enzyme becomes phosphorylated and inactive in the presence of acetate or ethanol YP_003047062.1 regulates the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase and isocitrate dehydrogenase kinase/phosphorylase YP_003047063.1 one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity YP_003047064.1 similar to b4020 YP_003047065.1 alpha-aspartyl dipeptidase; catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue; belongs to peptidase S51 family YP_003047066.1 catalyzes the synthesis of pseudouridine from U-2604 in the 23S ribosomal RNA YP_003047067.1 similar to b4023 YP_003047068.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive YP_003047069.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family YP_003047070.1 similar to b4026 YP_003047071.1 similar to b4027 YP_003047072.1 similar to b4028 YP_003047073.1 similar to b4029 YP_003047074.1 similar to b4030 YP_003047075.1 xylose/proton symporter; member of the major facilitator superfamily (MFS) of transporter YP_003047076.1 with MalKFE is involved in the transport of maltose into the cell YP_003047077.1 with MalKGE is involved in maltose transport into the cell YP_003047078.1 functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis YP_003047079.1 with malEFG is involved in import of maltose/maltodextrin YP_003047080.1 porin involved in the transport of maltose and maltodextrins YP_003047081.1 similar to b4037 YP_003047082.1 in E. coli, some yjbl mutations have been reported as suppressors of dnaG mutations YP_003047083.1 catalyzes the formation of 4-hydroxybenzoate from chorismate YP_003047084.1 catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway YP_003047085.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA YP_003047086.1 similar to b4042 YP_003047087.1 Represses a number of genes involved in the response to DNA damage YP_003047088.1 similar to b4044 YP_003047089.1 unknown function; highly abundant protein in vivo; overexpressed under high NaCl concentrations; part of the sigma S regulon; non-essential YP_003047090.1 Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes znuACB YP_003047091.1 similar to b4047 YP_003047092.1 similar to b4048 YP_003047093.1 similar to b4049 YP_003047094.1 coordinately regulated along with pspA; PspF-dependent induction in response to secretin overexpression in Yersinia YP_003047095.1 similar to b4051 YP_003047096.1 unwinds double stranded DNA YP_003047097.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer YP_003047098.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate YP_003047099.1 Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity YP_003047100.1 similar to b4056 YP_003047101.1 similar to b4057 YP_003047102.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate YP_003047103.1 binds to single stranded DNA and PriA helcase facilitate replication restart YP_003047104.1 similar to b4060 YP_003047105.1 regulates genes involved in response to oxidative stress YP_003047106.1 similar to b4063 YP_003047107.1 similar to b4064 YP_003047108.1 similar to b4065 YP_003047109.1 similar to b4066 YP_003047110.1 member of the sodium:solute symporter family; cotranscribed with the acs gene which encodes acetyl coenzyme A synthase; mutations affect acetate uptake YP_003047111.1 similar to b4068 YP_003047112.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA YP_003047113.1 catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552 YP_003047114.1 part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia YP_003047115.1 similar to b4072 YP_003047116.1 similar to b4073 YP_003047117.1 with NrfF and NrfG catalyzes the insertion of heme into cytochrome c552 YP_003047118.1 similar to b4075 YP_003047119.1 similar to b4076 YP_003047120.1 carrier protein part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system YP_003047121.1 similar to b4078 YP_003047122.1 similar to b4079; selenocysteine YP_003047123.1 part of a multidrug efflux system involved in resistance to acriflavin, puromycin, erytjhromycin and tetraphenylarsonium chloride; member of the outer membrane factor (OMF) family YP_003047124.1 possibly part of a tripartite efflux system composed of MdtN, MdtO and MdtP which could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride YP_003047125.1 with MdtO and MdtP is involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride YP_003047126.1 similar to b4083 YP_003047127.1 similar to b4084 YP_003047128.1 similar to b4085 YP_003047129.1 similar to b4086 YP_003047130.1 with AlsBC acts to import allose into the cell; AlsA contain 2 ATP-binding domains YP_003047131.1 similar to b4088 YP_003047132.1 involved in rpiB and als operon repression YP_003047133.1 catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity YP_003047134.1 similar to b4487 YP_003047135.1 required for the use of phosphonates and phosphite as phosphorus sources YP_003047136.1 PhnO in Salmonella enterica catalyzes the acetylation of a range of aminoalkylphosphonic acids; part of the biochemical pathway that enables the cell to use phosphonates as a phosphorus source; Escherichia coli uses a different mechanism of phosphonate catabolism where PhnO is not essential and seems to play a regulatory role YP_003047137.1 similar to b4094 YP_003047138.1 similar to b4095 YP_003047139.1 similar to b4096 YP_003047140.1 similar to b4097 YP_003047141.1 similar to b4098 YP_003047142.1 similar to b4099 YP_003047143.1 similar to b4100 YP_003047144.1 similar to b4101 YP_003047145.1 may be involved in phosphonate uptake and biodegradation YP_003047146.1 similar to b4103-b4104 YP_003047147.1 similar to b4105 YP_003047148.1 similar to b4106 YP_003047149.1 similar to b4107 YP_003047150.1 similar to b4108 YP_003047151.1 similar to b4109 YP_003047152.1 similar to b4110 YP_003047153.1 similar to b4111 YP_003047154.1 similar to b4112 YP_003047155.1 response regulator in two-component regulatory system with BasS YP_003047156.1 with ZipA and an unidentified 24 kDa protein forms a complex involved in cell division YP_003047157.1 similar to b4115 YP_003047158.1 similar to b4116 YP_003047159.1 similar to b4117 YP_003047160.1 similar to b4118 YP_003047161.1 similar to b4119 YP_003047162.1 similar to b4120 YP_003047163.1 similar to b4121 YP_003047164.1 similar to b4122 YP_003047165.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters YP_003047166.1 response regulator in two-component regulatory system with DcuS; phosphorylated DcuR activates transcription of genes involved in anaerobic fumarate respiration YP_003047167.1 similar to b4126 YP_003047168.1 similar to b4127 YP_003047169.1 similar to b4128 YP_003047170.1 class II; inducible; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; induced by high temperature, anaerobiosis, and low pH; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 YP_003047171.1 similar to b4130 YP_003047172.1 similar to b4131 YP_003047173.1 antiporter protein responsible for lysine import and cadaverine export; member of the lysine-dependent acid resistance system 4 (AR4); inner membrane protein YP_003047174.1 regulates the cadBA operon YP_003047175.1 similar to b4135 YP_003047176.1 two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm YP_003047177.1 copper binding protein required for copper tolerance; involved in resistance toward heavy metals YP_003047178.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB YP_003047179.1 catalyzes the formation of fumarate from aspartate YP_003047180.1 F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein YP_003047181.1 uncharacterized member of the APC superfamily of amino acid transporters; unknown function YP_003047182.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring YP_003047183.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth YP_003047184.1 similar to b4144 YP_003047185.1 similar to b4145 YP_003047186.1 similar to b4146 YP_003047187.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA YP_003047188.1 acts as and antidote to the bacteriolytic entericidin B in the EcnAB toxin-antitoxin complex YP_003047189.1 similar to b4411 YP_003047190.1 member of the SMR family of proton-dependent drug efflux transporters; quaternary ammonium compound efflux pump; confers resistance to cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations YP_003047191.1 lipocalin; globomycin-sensitive outer membrane lipoprotein YP_003047192.1 similar to b4150 YP_003047193.1 in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane YP_003047194.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB YP_003047195.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB YP_003047196.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB YP_003047197.1 lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_003047198.1 similar to b4156 YP_003047199.1 similar to b4159 YP_003047200.1 catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine YP_003047201.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity YP_003047202.1 3'-5' exoribonuclease specific for small oligoribonuclotides YP_003047203.1 similar to b4166 YP_003047204.1 similar to b4167 YP_003047205.1 possibly involved in cell wall synthesis YP_003047206.1 similar to b4169 YP_003047207.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex YP_003047208.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity YP_003047209.1 Stimulates the elongation of poly(A) tails YP_003047210.1 involved in modulation of proteins HflK and HflC; part of the hflA locus (high frequency of lysogenization) which governs the lysis-lysogeny decision of bacteriophage lambda by controlling stability of the phage cII protein YP_003047211.1 with HflC inhibits proteolysis of lambda cII protein by FtsH YP_003047212.1 with HflK inhibits proteolysis of lambda cII protein by FtsH YP_003047213.1 similar to b4176 YP_003047214.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis YP_003047215.1 negatively regulates the transcription of genes upregulated by nitrosative stress YP_003047216.1 3'-5'exoribonuclease that acts nonspecifically on poly(A), poly(U) and ribosomal RNAs YP_003047217.1 Specifically methylates the ribose of guanosine 2251 in 23S rRNA YP_003047218.1 similar to b4181 YP_003047219.1 similar to b4182 YP_003047220.1 similar to b4183 YP_003047221.1 similar to b4184 YP_003047222.1 similar to b4185 YP_003047223.1 similar to b4186 YP_003047224.1 catalyzes the formation of 3-methylcrotonyl-CoA from isovaleryl-CoA YP_003047225.1 similar to b4188 YP_003047226.1 in Escherichia coli, mutation of this gene affects biofilm maturation, stress response, and motility YP_003047227.1 YjfP; esterase activity towards palmitoyl-CoA and pNP-butyrate in vitro; unknown function and substrate in vivo YP_003047228.1 negative regulator of ulaG and ulaABCDEF YP_003047229.1 similar to b4192 YP_003047230.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr YP_003047231.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake YP_003047232.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake YP_003047233.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization YP_003047234.1 UlaE; catalyzes the epimerization of L-ribulose-5-phosphate into L-xylulose-5-phosphate; part of the anaerobic L-ascorbate degradation pathway YP_003047235.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source YP_003047236.1 similar to b4199 YP_003047237.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_003047238.1 binds single-stranded DNA at the primosome assembly site YP_003047239.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_003047240.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_003047246.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_003047247.1 similar to b4205 YP_003047248.1 similar to b4206 YP_003047249.1 FKBP-type; rotamase; catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides YP_003047250.1 involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine YP_003047251.1 Involved in anaerobic NO protection and iron metabolism YP_003047252.1 similar to b4210 YP_003047253.1 similar to b4211 YP_003047254.1 similar to b4212 YP_003047255.1 periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate YP_003047256.1 catalyzes the formation of AMP from adenosine-3',5'-bisphosphate YP_003047257.1 similar to b4216 YP_003047258.1 similar to b4217 YP_003047259.1 similar to b4218 YP_003047260.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress YP_003047261.1 similar to b4220 YP_003047262.1 similar to b4221 YP_003047265.1 catalyzes the hydrolysis of pyrophosphate to phosphate YP_003047266.1 similar to b4227 YP_003047267.1 similar to b4485 YP_003047268.1 similar to b4230 YP_003047269.1 membrane component of a putative sugar ABC transporter system YP_003047270.1 catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate YP_003047271.1 similar to b4233 YP_003047272.1 similar to b4234 YP_003047273.1 protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD YP_003047274.1 activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions YP_003047275.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates YP_003047276.1 similar to b4239 YP_003047277.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_003047278.1 regulates genes involved in trehalose metabolism; binds the intermediate trehalose-6-phosphate; binds a dimer; regulates treBC operon YP_003047279.1 P-type ATPase involved in magnesium influx YP_003047280.1 similar to b4243 YP_003047281.1 involved in the allosteric regulation of aspartate carbamoyltransferase YP_003047282.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis YP_003047283.1 similar to b4246 YP_003047284.1 similar to b4248 YP_003047285.1 similar to b4249 YP_003047286.1 similar to b4251 YP_003047287.1 similar to b4252 YP_003047288.1 similar to b4253 YP_003047289.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; E. coli K12 has two genes, argF and argI, capable of producing functional ornithine carbamoyltransferase. When both are active in the same cell, the two gene products form a family of four hybrid trimeric isoenzymes designated, FFF, FFI, FII, and III. YP_003047290.1 similar to b4255 YP_003047291.1 similar to b4256 YP_003047292.1 similar to b4257 YP_003047293.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_003047294.1 binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB YP_003047295.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides YP_003047296.1 similar to b4261 YP_003047297.1 similar to b4262 YP_003047298.1 similar to b4263 YP_003047299.1 similar to b4264 YP_003047300.1 similar to b4265 YP_003047301.1 Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate YP_003047302.1 NAD-binding YP_003047303.1 similar to b4268 YP_003047304.1 similar to b4269 YP_003047305.1 similar to b4271 YP_003047306.1 similar to b4274 YP_003047307.1 similar to b4277 YP_003047308.1 similar to b4278 YP_003047309.1 similar to b4279 YP_003047310.1 similar to b4280 YP_003047317.1 similar to b4286 YP_003047318.1 Part of the FecBCDE citrate-dependent iron (III) transport system YP_003047319.1 Ferric citrate binds FecA and is transported across the outer membrane while transmits a signal across the cytoplasmic membrane protein FecR. FecR transmits a signal across the membrane and activates the cytoplasmic FecI that directs the RNA polymerase to express the fecABCDE operon (which encodes the ferric citrate outer membrane receptor and the ferric citrate ABC transporter), as well as fecIR. FecD is one of two (along with FecC) integral membrane protein components of the iron dicitrate ABC transporter. YP_003047320.1 part of the FecBCDE citrate-dependent iron (III) transport system YP_003047321.1 part of the ABC transporter involved in the uptake of citrate-dependent Fe(3+) YP_003047322.1 similar to b4291 YP_003047323.1 with FecA forms the FecAR signal transduction system; ferric citrate binds FecA and transmits a signal across the outer membrane to FecR. FecR transmits a signal across the cytoplasmic membrane and activates the sigma 70 protein FecI that directs the RNA polymerase to express the fecABCDE operon YP_003047324.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor regulates the genes for iron dicitrate transport YP_003047329.1 similar to b4300 YP_003047330.1 similar to b4301 YP_003047331.1 similar to b4302 YP_003047332.1 similar to b4303 YP_003047333.1 similar to b4304 YP_003047334.1 similar to b4565 YP_003047335.1 similar to b4305 YP_003047336.1 similar to b4306 YP_003047337.1 similar to b4307 YP_003047338.1 similar to b4566 YP_003047339.1 similar to b4309 YP_003047340.1 similar to b4310 YP_003047341.1 similar to b4311 YP_003047344.1 inversion of on/off regulator of fimA YP_003047345.1 similar to b4314 YP_003047346.1 similar to b4315 YP_003047347.1 similar to b4316 YP_003047348.1 similar to b4317 YP_003047349.1 similar to b4318 YP_003047350.1 similar to b4319 YP_003047351.1 similar to b4320 YP_003047352.1 similar to b4321 YP_003047353.1 catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate YP_003047354.1 similar to b4323 YP_003047355.1 regulates the expression of uxuBA YP_003047356.1 similar to b4325 YP_003047357.1 inhibitor of RssB activity in response to DNA damage; blocks degradation of stationary phase sigma factor RpoS YP_003047358.1 similar to b4327 YP_003047359.1 similar to b4328 YP_003047360.1 similar to b4329 YP_003047361.1 similar to b4330 YP_003047362.1 in yeast cells this enzyme removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate; functions in tRNA splicing; the function and substrate of bacterial enzymes in organisms that do not perform splicing is unknown YP_003047363.1 similar to b4332 YP_003047364.1 similar to b4333 YP_003047365.1 similar to b4334 YP_003047366.1 similar to b4335 YP_003047367.1 similar to b4336 YP_003047368.1 similar to b4337 YP_003047369.1 similar to b4338-b4339 YP_003047372.1 McrC protein together with McrB forms the McrBC restriction system; recognizes N4- and C5-methylcytosine (and 5-hydroxy-methylcytosines); appears to act against 5-methylcytosine preceded by a purine residue; MrcC modulates the specificty of McrB and has DNA cleavage activity YP_003047373.1 McrB protein together with McrC forms the McrBC restriction system; recognizes N4- and C5-methylcytosine (and 5-hydroxy-methylcytosines); appears to act against 5-methylcytosine preceded by a purine residue YP_003047374.1 involved in the degradation of RNA; may be involved in the recycling of RNA during the SOS response YP_003047375.1 similar to b4348 YP_003047376.1 similar to b4349 YP_003047377.1 restriction endonuclease; the EcoKI enzyme recognizes 5'-AACN(6)GTGC-3'; subunit R is required for both nuclease and ATPase activities YP_003047378.1 similar to b4351 YP_003047379.1 similar to b4352 YP_003047380.1 similar to b4353 YP_003047381.1 similar to b4354 YP_003047393.1 similar to b4355 YP_003047394.1 similar to b4356 YP_003047395.1 similar to b4358 YP_003047396.1 catalyzes the transfer of phosphoglycerol to the glucan backbone YP_003047397.1 similar to b4360 YP_003047398.1 acts to load the DnaB helicase onto the initiation site during DNA replication YP_003047399.1 This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with dnaB protein and other prepriming proteins dnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' YP_003047400.1 similar to b4363 YP_003047401.1 similar to b4364 YP_003047402.1 similar to b4365 YP_003047403.1 regulator for the transport and utilization of the aromatic beta-glucosides arbutin and silicin YP_003047404.1 similar to b4367 YP_003047405.1 similar to b4567 YP_003047406.1 16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit YP_003047407.1 with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB YP_003047408.1 alanine acetyltransferase that specifically acetylates ribosomal protein S18 YP_003047409.1 manganese-dependent 5'-nucleotidase; specific for 5'-UMP, 5'-dUMP, and 5'-dTMP; member of haloacid dehalogenase (HAD)-like hydrolase superfamily YP_003047410.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein YP_003047411.1 similar to b4376 YP_003047412.1 similar to b4568 YP_003047413.1 similar to b4377 YP_003047414.1 similar to b4378 YP_003047415.1 similar to b4379 YP_003047416.1 similar to b4380 YP_003047417.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate YP_003047418.1 Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate YP_003047419.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose YP_003047420.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate YP_003047422.1 Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl on the lipoate-dependent enzymes. Creates an amide linkage that joins the free carboxyl group of lipoic acid to the epsilon-amino group of a specific lysine residue in lipoyl domain of apoproteins YP_003047423.1 similar to b4387 YP_003047424.1 catalyzes the formation of serine from O-phosphoserine YP_003047425.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_003047426.1 catalyzes the formation of NAD(+) from nicotinamide ribonucleotide YP_003047427.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence YP_003047428.1 catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan YP_003047429.1 When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription YP_003047430.1 pyrophosphatase; has activity against dUTP and dITP; the crystal structure of the Vibrio protein showed similarity to Methanococcus janaschii Mj0226; in Vibrio cholerae this gene is part of the Mba operon that is involved in regulation and maintenance of biofilms; in Escherichia coli overexpression of this gene leads to resistance to an HMP analog YP_003047431.1 catalyzes reactions involving the transfer of phospho groups between the three carbon atoms of phosphoglycerate YP_003047432.1 similar to b4396 YP_003047433.1 similar to b4397 YP_003047434.1 response regulator in two-component regulatory system with CreC; CreB protein is phosphorylated by sensor protein phospho-CreC; involved in catabolic regulation YP_003047435.1 part of a two-component regulatory system with CreB or PhoB; involved in catabolic regulation YP_003047436.1 similar to b4401 YP_003047437.1 similar to b4402 YP_003047438.1 member of the SPOUT superfamily of methyltransferases