-- dump date 20140619_075728 -- class Genbank::misc_feature -- table misc_feature_note -- id note 314225000001 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 314225000002 flagellin; Validated; Region: PRK08026 314225000003 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 314225000004 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 314225000005 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 314225000006 DNA binding residues [nucleotide binding] 314225000007 dimerization interface [polypeptide binding]; other site 314225000008 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 314225000009 Ligand binding site; other site 314225000010 Putative Catalytic site; other site 314225000011 DXD motif; other site 314225000012 Predicted membrane protein [Function unknown]; Region: COG2246 314225000013 GtrA-like protein; Region: GtrA; pfam04138 314225000014 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 314225000015 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 314225000016 active site 314225000017 acetyl-CoA acetyltransferase; Provisional; Region: PRK06025 314225000018 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 314225000019 dimer interface [polypeptide binding]; other site 314225000020 active site 314225000021 enoyl-CoA hydratase; Provisional; Region: PRK08252 314225000022 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 314225000023 substrate binding site [chemical binding]; other site 314225000024 oxyanion hole (OAH) forming residues; other site 314225000025 trimer interface [polypeptide binding]; other site 314225000026 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 314225000027 CoA-transferase family III; Region: CoA_transf_3; pfam02515 314225000028 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 314225000029 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 314225000030 active site 314225000031 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 314225000032 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 314225000033 23S rRNA interface [nucleotide binding]; other site 314225000034 L7/L12 interface [polypeptide binding]; other site 314225000035 putative thiostrepton binding site; other site 314225000036 L25 interface [polypeptide binding]; other site 314225000037 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 314225000038 mRNA/rRNA interface [nucleotide binding]; other site 314225000039 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u9; cd10933 314225000040 putative active site [active] 314225000041 putative catalytic site [active] 314225000042 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 314225000043 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 314225000044 putative MPT binding site; other site 314225000045 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 314225000046 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 314225000047 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 314225000048 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 314225000049 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 314225000050 Cytochrome P450; Region: p450; pfam00067 314225000051 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 314225000052 Flavodoxin; Region: Flavodoxin_1; pfam00258 314225000053 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 314225000054 FAD binding pocket [chemical binding]; other site 314225000055 FAD binding motif [chemical binding]; other site 314225000056 catalytic residues [active] 314225000057 NAD binding pocket [chemical binding]; other site 314225000058 phosphate binding motif [ion binding]; other site 314225000059 beta-alpha-beta structure motif; other site 314225000060 integrase; Provisional; Region: PRK09692 314225000061 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 314225000062 active site 314225000063 Int/Topo IB signature motif; other site 314225000064 Protein of unknown function (DUF1134); Region: DUF1134; pfam06577 314225000065 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 314225000066 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 314225000067 pyridoxal 5'-phosphate binding site [chemical binding]; other site 314225000068 homodimer interface [polypeptide binding]; other site 314225000069 catalytic residue [active] 314225000070 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 314225000071 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 314225000072 Lumazine binding domain; Region: Lum_binding; pfam00677 314225000073 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 314225000074 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 314225000075 catalytic motif [active] 314225000076 Zn binding site [ion binding]; other site 314225000077 RibD C-terminal domain; Region: RibD_C; pfam01872 314225000078 Protein of unknown function DUF45; Region: DUF45; pfam01863 314225000079 hypothetical protein; Provisional; Region: PRK05170 314225000080 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 314225000081 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 314225000082 Cu(I) binding site [ion binding]; other site 314225000083 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 314225000084 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 314225000085 rpsU-divergently transcribed protein; Region: diverge_rpsU; TIGR02396 314225000086 COQ9; Region: COQ9; pfam08511 314225000087 FeoA domain; Region: FeoA; pfam04023 314225000088 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 314225000089 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 314225000090 G1 box; other site 314225000091 GTP/Mg2+ binding site [chemical binding]; other site 314225000092 Switch I region; other site 314225000093 G2 box; other site 314225000094 G3 box; other site 314225000095 Switch II region; other site 314225000096 G4 box; other site 314225000097 G5 box; other site 314225000098 Nucleoside recognition; Region: Gate; pfam07670 314225000099 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 314225000100 Nucleoside recognition; Region: Gate; pfam07670 314225000101 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 314225000102 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 314225000103 dimer interface [polypeptide binding]; other site 314225000104 ssDNA binding site [nucleotide binding]; other site 314225000105 tetramer (dimer of dimers) interface [polypeptide binding]; other site 314225000106 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 314225000107 Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045 314225000108 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 314225000109 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 314225000110 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 314225000111 active site 314225000112 HslU subunit interaction site [polypeptide binding]; other site 314225000113 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 314225000114 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 314225000115 Walker A motif; other site 314225000116 ATP binding site [chemical binding]; other site 314225000117 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 314225000118 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 314225000119 ACT domain; Region: ACT_3; pfam10000 314225000120 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 314225000121 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 314225000122 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 314225000123 Sulfate transporter family; Region: Sulfate_transp; pfam00916 314225000124 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 314225000125 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 314225000126 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 314225000127 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 314225000128 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 314225000129 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 314225000130 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 314225000131 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 314225000132 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 314225000133 Walker A/P-loop; other site 314225000134 ATP binding site [chemical binding]; other site 314225000135 Q-loop/lid; other site 314225000136 ABC transporter signature motif; other site 314225000137 Walker B; other site 314225000138 D-loop; other site 314225000139 H-loop/switch region; other site 314225000140 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 314225000141 catalytic motif [active] 314225000142 Catalytic residue [active] 314225000143 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 314225000144 catalytic motif [active] 314225000145 Catalytic residue [active] 314225000146 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 314225000147 colanic acid exporter; Provisional; Region: PRK10459 314225000148 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 314225000149 active site 314225000150 substrate binding sites [chemical binding]; other site 314225000151 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 314225000152 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 314225000153 catalytic residue [active] 314225000154 TIR domain; Region: TIR_2; pfam13676 314225000155 Predicted integral membrane protein [Function unknown]; Region: COG5616 314225000156 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 314225000157 binding surface 314225000158 TPR motif; other site 314225000159 Tetratricopeptide repeat; Region: TPR_16; pfam13432 314225000160 Tetratricopeptide repeat; Region: TPR_16; pfam13432 314225000161 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 314225000162 Ion channel; Region: Ion_trans_2; pfam07885 314225000163 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 314225000164 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 314225000165 active site 314225000166 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 314225000167 MFS/sugar transport protein; Region: MFS_2; pfam13347 314225000168 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 314225000169 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 314225000170 active site 314225000171 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 314225000172 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 314225000173 active site 314225000174 Major Facilitator Superfamily; Region: MFS_1; pfam07690 314225000175 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 314225000176 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 314225000177 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 314225000178 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 314225000179 acyl-activating enzyme (AAE) consensus motif; other site 314225000180 acyl-activating enzyme (AAE) consensus motif; other site 314225000181 putative AMP binding site [chemical binding]; other site 314225000182 putative active site [active] 314225000183 putative CoA binding site [chemical binding]; other site 314225000184 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 314225000185 Beta-lactamase; Region: Beta-lactamase; pfam00144 314225000186 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 314225000187 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 314225000188 substrate binding site [chemical binding]; other site 314225000189 oxyanion hole (OAH) forming residues; other site 314225000190 trimer interface [polypeptide binding]; other site 314225000191 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 314225000192 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 314225000193 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 314225000194 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 314225000195 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 314225000196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 314225000197 Major Facilitator Superfamily; Region: MFS_1; pfam07690 314225000198 putative substrate translocation pore; other site 314225000199 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 314225000200 glutathionine S-transferase; Provisional; Region: PRK10542 314225000201 C-terminal domain interface [polypeptide binding]; other site 314225000202 GSH binding site (G-site) [chemical binding]; other site 314225000203 dimer interface [polypeptide binding]; other site 314225000204 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 314225000205 dimer interface [polypeptide binding]; other site 314225000206 substrate binding pocket (H-site) [chemical binding]; other site 314225000207 N-terminal domain interface [polypeptide binding]; other site 314225000208 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 314225000209 Radical SAM superfamily; Region: Radical_SAM; pfam04055 314225000210 FeS/SAM binding site; other site 314225000211 mercuric reductase; Validated; Region: PRK06370 314225000212 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 314225000213 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 314225000214 Methyltransferase domain; Region: Methyltransf_31; pfam13847 314225000215 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 314225000216 S-adenosylmethionine binding site [chemical binding]; other site 314225000217 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 314225000218 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 314225000219 putative NAD(P) binding site [chemical binding]; other site 314225000220 active site 314225000221 putative substrate binding site [chemical binding]; other site 314225000222 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 314225000223 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 314225000224 Probable Catalytic site; other site 314225000225 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 314225000226 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 314225000227 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 314225000228 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 314225000229 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 314225000230 catalytic loop [active] 314225000231 iron binding site [ion binding]; other site 314225000232 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 314225000233 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 314225000234 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 314225000235 N-terminal plug; other site 314225000236 ligand-binding site [chemical binding]; other site 314225000237 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 314225000238 ArsC family; Region: ArsC; pfam03960 314225000239 catalytic residues [active] 314225000240 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 314225000241 Major Facilitator Superfamily; Region: MFS_1; pfam07690 314225000242 putative substrate translocation pore; other site 314225000243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 314225000244 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 314225000245 S-adenosylmethionine binding site [chemical binding]; other site 314225000246 lipoate-protein ligase B; Provisional; Region: PRK14341 314225000247 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 314225000248 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 314225000249 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 314225000250 FMN binding site [chemical binding]; other site 314225000251 active site 314225000252 substrate binding site [chemical binding]; other site 314225000253 catalytic residue [active] 314225000254 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 314225000255 Predicted membrane protein [Function unknown]; Region: COG4325 314225000256 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 314225000257 quinolinate synthetase; Provisional; Region: PRK09375 314225000258 AMP-binding domain protein; Validated; Region: PRK08315 314225000259 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 314225000260 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 314225000261 acyl-activating enzyme (AAE) consensus motif; other site 314225000262 acyl-activating enzyme (AAE) consensus motif; other site 314225000263 putative AMP binding site [chemical binding]; other site 314225000264 putative active site [active] 314225000265 putative CoA binding site [chemical binding]; other site 314225000266 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 314225000267 Tetratricopeptide repeat; Region: TPR_16; pfam13432 314225000268 binding surface 314225000269 TPR motif; other site 314225000270 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 314225000271 TPR motif; other site 314225000272 binding surface 314225000273 TPR repeat; Region: TPR_11; pfam13414 314225000274 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 314225000275 TPR motif; other site 314225000276 binding surface 314225000277 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 314225000278 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 314225000279 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 314225000280 BCCT family transporter; Region: BCCT; pfam02028 314225000281 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 314225000282 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 314225000283 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 314225000284 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 314225000285 N- and C-terminal domain interface [polypeptide binding]; other site 314225000286 active site 314225000287 MgATP binding site [chemical binding]; other site 314225000288 catalytic site [active] 314225000289 metal binding site [ion binding]; metal-binding site 314225000290 glycerol binding site [chemical binding]; other site 314225000291 homotetramer interface [polypeptide binding]; other site 314225000292 homodimer interface [polypeptide binding]; other site 314225000293 FBP binding site [chemical binding]; other site 314225000294 protein IIAGlc interface [polypeptide binding]; other site 314225000295 Protein of unknown function (DUF1465); Region: DUF1465; pfam07323 314225000296 Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481 314225000297 Protein of unknown function (DUF465); Region: DUF465; cl01070 314225000298 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 314225000299 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 314225000300 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 314225000301 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 314225000302 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 314225000303 Helix-turn-helix domain; Region: HTH_25; pfam13413 314225000304 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 314225000305 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 314225000306 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 314225000307 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 314225000308 Ligand Binding Site [chemical binding]; other site 314225000309 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 314225000310 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 314225000311 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 314225000312 active site 314225000313 intersubunit interface [polypeptide binding]; other site 314225000314 catalytic residue [active] 314225000315 Glucokinase; Region: Glucokinase; pfam02685 314225000316 glucokinase, proteobacterial type; Region: glk; TIGR00749 314225000317 phosphogluconate dehydratase; Validated; Region: PRK09054 314225000318 6-phosphogluconate dehydratase; Region: edd; TIGR01196 314225000319 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 314225000320 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 314225000321 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 314225000322 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 314225000323 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 314225000324 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 314225000325 trimer interface [polypeptide binding]; other site 314225000326 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 314225000327 trimer interface [polypeptide binding]; other site 314225000328 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 314225000329 trimer interface [polypeptide binding]; other site 314225000330 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 314225000331 trimer interface [polypeptide binding]; other site 314225000332 Haemagglutinin; Region: HIM; pfam05662 314225000333 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 314225000334 trimer interface [polypeptide binding]; other site 314225000335 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 314225000336 trimer interface [polypeptide binding]; other site 314225000337 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 314225000338 trimer interface [polypeptide binding]; other site 314225000339 YadA-like C-terminal region; Region: YadA; pfam03895 314225000340 Anti-sigma-K factor rskA; Region: RskA; pfam10099 314225000341 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 314225000342 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 314225000343 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 314225000344 DNA binding residues [nucleotide binding] 314225000345 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 314225000346 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 314225000347 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 314225000348 FeS/SAM binding site; other site 314225000349 Protein of unknown function (DUF1761); Region: DUF1761; pfam08570 314225000350 Ion channel; Region: Ion_trans_2; pfam07885 314225000351 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 314225000352 TrkA-N domain; Region: TrkA_N; pfam02254 314225000353 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 314225000354 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 314225000355 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 314225000356 Peptidase family M23; Region: Peptidase_M23; pfam01551 314225000357 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 314225000358 seryl-tRNA synthetase; Provisional; Region: PRK05431 314225000359 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 314225000360 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 314225000361 dimer interface [polypeptide binding]; other site 314225000362 active site 314225000363 motif 1; other site 314225000364 motif 2; other site 314225000365 motif 3; other site 314225000366 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 314225000367 DNA binding site [nucleotide binding] 314225000368 Int/Topo IB signature motif; other site 314225000369 active site 314225000370 catalytic residues [active] 314225000371 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 314225000372 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 314225000373 N-acetyl-D-glucosamine binding site [chemical binding]; other site 314225000374 catalytic residue [active] 314225000375 Toprim domain; Region: Toprim_3; pfam13362 314225000376 Methyltransferase domain; Region: Methyltransf_26; pfam13659 314225000377 P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872 314225000378 Helicase_C-like; Region: Helicase_C_4; pfam13871 314225000379 ParB-like nuclease domain; Region: ParB; smart00470 314225000380 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 314225000381 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 314225000382 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 314225000383 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 314225000384 RES domain; Region: RES; smart00953 314225000385 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 314225000386 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 314225000387 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 314225000388 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 314225000389 dimer interface [polypeptide binding]; other site 314225000390 ssDNA binding site [nucleotide binding]; other site 314225000391 tetramer (dimer of dimers) interface [polypeptide binding]; other site 314225000392 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 314225000393 active site 314225000394 DNA binding site [nucleotide binding] 314225000395 Int/Topo IB signature motif; other site 314225000396 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 314225000397 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 314225000398 active site 314225000399 DNA binding site [nucleotide binding] 314225000400 Int/Topo IB signature motif; other site 314225000401 putative acetyltransferase; Provisional; Region: PRK03624 314225000402 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 314225000403 Coenzyme A binding pocket [chemical binding]; other site 314225000404 Methyltransferase domain; Region: Methyltransf_26; pfam13659 314225000405 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 314225000406 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 314225000407 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 314225000408 HTH-like domain; Region: HTH_21; pfam13276 314225000409 Integrase core domain; Region: rve; pfam00665 314225000410 Integrase core domain; Region: rve_3; pfam13683 314225000411 Transposase; Region: HTH_Tnp_1; pfam01527 314225000412 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 314225000413 Walker A/P-loop; other site 314225000414 ATP binding site [chemical binding]; other site 314225000415 Transposase; Region: HTH_Tnp_1; pfam01527 314225000416 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 314225000417 HTH-like domain; Region: HTH_21; pfam13276 314225000418 Integrase core domain; Region: rve; pfam00665 314225000419 Integrase core domain; Region: rve_3; pfam13683 314225000420 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 314225000421 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 314225000422 Walker A motif; other site 314225000423 ATP binding site [chemical binding]; other site 314225000424 Walker B motif; other site 314225000425 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 314225000426 TrwC relaxase; Region: TrwC; pfam08751 314225000427 AAA domain; Region: AAA_30; pfam13604 314225000428 Family description; Region: UvrD_C_2; pfam13538 314225000429 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 314225000430 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 314225000431 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 314225000432 substrate binding site [chemical binding]; other site 314225000433 ATP binding site [chemical binding]; other site 314225000434 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 314225000435 Predicted transcriptional regulator [Transcription]; Region: COG2932 314225000436 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 314225000437 Catalytic site [active] 314225000438 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 314225000439 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 314225000440 Catalytic site; other site 314225000441 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 314225000442 Conjugative relaxosome accessory transposon protein; Region: TraH; pfam06122 314225000443 F plasmid transfer operon protein; Region: TraF; pfam13728 314225000444 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 314225000445 catalytic residues [active] 314225000446 conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355 314225000447 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673 314225000448 TraU protein; Region: TraU; pfam06834 314225000449 Sex factor F TraW protein N terminal; Region: TraW_N; cl10149 314225000450 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 314225000451 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 314225000452 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 314225000453 type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746 314225000454 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 314225000455 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 314225000456 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 314225000457 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 314225000458 dimerization domain [polypeptide binding]; other site 314225000459 dimer interface [polypeptide binding]; other site 314225000460 catalytic residues [active] 314225000461 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 314225000462 TraK protein; Region: TraK; pfam06586 314225000463 conjugal transfer protein TraK; Provisional; Region: PRK13736; cl05878 314225000464 TraE protein; Region: TraE; pfam05309 314225000465 TraL protein; Region: TraL; pfam07178 314225000466 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 314225000467 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 314225000468 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 314225000469 dimerization interface [polypeptide binding]; other site 314225000470 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 314225000471 CoenzymeA binding site [chemical binding]; other site 314225000472 subunit interaction site [polypeptide binding]; other site 314225000473 PHB binding site; other site 314225000474 Protein of unknown function (DUF2855); Region: DUF2855; pfam11017 314225000475 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 314225000476 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 314225000477 N-terminal plug; other site 314225000478 ligand-binding site [chemical binding]; other site 314225000479 PhoD-like phosphatase; Region: PhoD; pfam09423 314225000480 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 314225000481 putative active site [active] 314225000482 putative metal binding site [ion binding]; other site 314225000483 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 314225000484 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 314225000485 CoA-transferase family III; Region: CoA_transf_3; pfam02515 314225000486 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 314225000487 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 314225000488 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 314225000489 acyl-activating enzyme (AAE) consensus motif; other site 314225000490 acyl-activating enzyme (AAE) consensus motif; other site 314225000491 putative AMP binding site [chemical binding]; other site 314225000492 putative active site [active] 314225000493 putative CoA binding site [chemical binding]; other site 314225000494 enoyl-CoA hydratase; Provisional; Region: PRK06688 314225000495 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 314225000496 substrate binding site [chemical binding]; other site 314225000497 oxyanion hole (OAH) forming residues; other site 314225000498 trimer interface [polypeptide binding]; other site 314225000499 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 314225000500 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 314225000501 active site 314225000502 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 314225000503 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 314225000504 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 314225000505 active site 314225000506 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 314225000507 homodimer interface [polypeptide binding]; other site 314225000508 short chain dehydrogenase; Provisional; Region: PRK07791 314225000509 NAD binding site [chemical binding]; other site 314225000510 active site 314225000511 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 314225000512 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 314225000513 N-terminal plug; other site 314225000514 ligand-binding site [chemical binding]; other site 314225000515 Transcriptional regulator [Transcription]; Region: LysR; COG0583 314225000516 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 314225000517 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 314225000518 dimerization interface [polypeptide binding]; other site 314225000519 Helix-turn-helix domain; Region: HTH_28; pfam13518 314225000520 Winged helix-turn helix; Region: HTH_29; pfam13551 314225000521 Homeodomain-like domain; Region: HTH_32; pfam13565 314225000522 Integrase core domain; Region: rve; pfam00665 314225000523 Integrase core domain; Region: rve_3; pfam13683 314225000524 Transposase; Region: HTH_Tnp_1; pfam01527 314225000525 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 314225000526 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 314225000527 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 314225000528 oligomer interface [polypeptide binding]; other site 314225000529 tandem repeat interface [polypeptide binding]; other site 314225000530 active site residues [active] 314225000531 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 314225000532 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 314225000533 tandem repeat interface [polypeptide binding]; other site 314225000534 oligomer interface [polypeptide binding]; other site 314225000535 active site residues [active] 314225000536 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 314225000537 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 314225000538 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 314225000539 dihydroorotase; Validated; Region: pyrC; PRK09357 314225000540 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 314225000541 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 314225000542 active site 314225000543 PilZ domain; Region: PilZ; pfam07238 314225000544 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 314225000545 TPR motif; other site 314225000546 binding surface 314225000547 Sporulation related domain; Region: SPOR; pfam05036 314225000548 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 314225000549 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 314225000550 P-loop; other site 314225000551 Magnesium ion binding site [ion binding]; other site 314225000552 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 314225000553 Sel1-like repeats; Region: SEL1; smart00671 314225000554 Sporulation related domain; Region: SPOR; pfam05036 314225000555 Predicted membrane protein [Function unknown]; Region: COG2311 314225000556 Protein of unknown function (DUF418); Region: DUF418; cl12135 314225000557 Protein of unknown function (DUF418); Region: DUF418; pfam04235 314225000558 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 314225000559 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 314225000560 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 314225000561 heme binding site [chemical binding]; other site 314225000562 ferroxidase pore; other site 314225000563 ferroxidase diiron center [ion binding]; other site 314225000564 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 314225000565 GTP-binding protein Der; Reviewed; Region: PRK00093 314225000566 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 314225000567 G1 box; other site 314225000568 GTP/Mg2+ binding site [chemical binding]; other site 314225000569 Switch I region; other site 314225000570 G2 box; other site 314225000571 Switch II region; other site 314225000572 G3 box; other site 314225000573 G4 box; other site 314225000574 G5 box; other site 314225000575 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 314225000576 G1 box; other site 314225000577 GTP/Mg2+ binding site [chemical binding]; other site 314225000578 Switch I region; other site 314225000579 G2 box; other site 314225000580 G3 box; other site 314225000581 Switch II region; other site 314225000582 G4 box; other site 314225000583 G5 box; other site 314225000584 Surface antigen [General function prediction only]; Region: COG3942 314225000585 CHAP domain; Region: CHAP; cl17642 314225000586 Protein of unknown function (DUF3297); Region: DUF3297; pfam11730 314225000587 autotransport protein MisL; Provisional; Region: PRK15313 314225000588 trigger factor; Provisional; Region: tig; PRK01490 314225000589 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 314225000590 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 314225000591 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 314225000592 Amidase; Region: Amidase; cl11426 314225000593 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 314225000594 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 314225000595 Clp protease; Region: CLP_protease; pfam00574 314225000596 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 314225000597 oligomer interface [polypeptide binding]; other site 314225000598 active site residues [active] 314225000599 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 314225000600 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 314225000601 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 314225000602 Walker A motif; other site 314225000603 ATP binding site [chemical binding]; other site 314225000604 Walker B motif; other site 314225000605 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 314225000606 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 314225000607 Fasciclin domain; Region: Fasciclin; pfam02469 314225000608 Anti-sigma-K factor rskA; Region: RskA; pfam10099 314225000609 RNA polymerase sigma factor; Provisional; Region: PRK12514 314225000610 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 314225000611 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 314225000612 DNA binding residues [nucleotide binding] 314225000613 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 314225000614 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 314225000615 Transglycosylase; Region: Transgly; cl17702 314225000616 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 314225000617 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 314225000618 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 314225000619 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 314225000620 DNA binding residues [nucleotide binding] 314225000621 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 314225000622 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 314225000623 RNA binding surface [nucleotide binding]; other site 314225000624 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 314225000625 active site 314225000626 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 314225000627 MPN+ (JAMM) motif; other site 314225000628 Zinc-binding site [ion binding]; other site 314225000629 Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090 314225000630 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 314225000631 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 314225000632 amidase catalytic site [active] 314225000633 Zn binding residues [ion binding]; other site 314225000634 substrate binding site [chemical binding]; other site 314225000635 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 314225000636 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 314225000637 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 314225000638 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 314225000639 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 314225000640 active site 314225000641 Autotransporter beta-domain; Region: Autotransporter; smart00869 314225000642 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 314225000643 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 314225000644 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 314225000645 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 314225000646 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 314225000647 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 314225000648 active site 314225000649 metal binding site [ion binding]; metal-binding site 314225000650 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; pfam09694 314225000651 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 314225000652 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 314225000653 dimer interface [polypeptide binding]; other site 314225000654 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 314225000655 active site 314225000656 metal binding site [ion binding]; metal-binding site 314225000657 glutathione binding site [chemical binding]; other site 314225000658 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 314225000659 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 314225000660 active site 314225000661 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 314225000662 Predicted permeases [General function prediction only]; Region: COG0730 314225000663 Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; pfam09608 314225000664 Domain of unknown function DUF87; Region: DUF87; pfam01935 314225000665 AAA-like domain; Region: AAA_10; pfam12846 314225000666 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 314225000667 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 314225000668 FeS/SAM binding site; other site 314225000669 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 314225000670 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 314225000671 tRNA synthetases class I (I, L, M and V); Region: tRNA-synt_1; pfam00133 314225000672 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 314225000673 active site 314225000674 HIGH motif; other site 314225000675 nucleotide binding site [chemical binding]; other site 314225000676 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 314225000677 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 314225000678 active site 314225000679 KMSKS motif; other site 314225000680 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 314225000681 tRNA binding surface [nucleotide binding]; other site 314225000682 anticodon binding site; other site 314225000683 Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264 314225000684 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 314225000685 Permease; Region: Permease; pfam02405 314225000686 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 314225000687 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 314225000688 Walker A/P-loop; other site 314225000689 ATP binding site [chemical binding]; other site 314225000690 Q-loop/lid; other site 314225000691 ABC transporter signature motif; other site 314225000692 Walker B; other site 314225000693 D-loop; other site 314225000694 H-loop/switch region; other site 314225000695 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 314225000696 mce related protein; Region: MCE; pfam02470 314225000697 Protein of unknown function (DUF330); Region: DUF330; cl01135 314225000698 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 314225000699 RNA binding site [nucleotide binding]; other site 314225000700 ATP12 chaperone protein; Region: ATP12; pfam07542 314225000701 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 314225000702 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 314225000703 motif II; other site 314225000704 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 314225000705 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 314225000706 active site 314225000707 camphor resistance protein CrcB; Provisional; Region: PRK14195 314225000708 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 314225000709 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 314225000710 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 314225000711 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 314225000712 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 314225000713 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 314225000714 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 314225000715 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 314225000716 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 314225000717 GatB domain; Region: GatB_Yqey; smart00845 314225000718 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 314225000719 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 314225000720 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 314225000721 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 314225000722 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 314225000723 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 314225000724 Penicillin amidase; Region: Penicil_amidase; pfam01804 314225000725 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 314225000726 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 314225000727 active site 314225000728 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 314225000729 Domain of unknown function DUF87; Region: DUF87; pfam01935 314225000730 HerA helicase [Replication, recombination, and repair]; Region: COG0433 314225000731 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 314225000732 Clp amino terminal domain; Region: Clp_N; pfam02861 314225000733 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 314225000734 Walker A motif; other site 314225000735 ATP binding site [chemical binding]; other site 314225000736 Walker B motif; other site 314225000737 arginine finger; other site 314225000738 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 314225000739 Walker A motif; other site 314225000740 ATP binding site [chemical binding]; other site 314225000741 Walker B motif; other site 314225000742 arginine finger; other site 314225000743 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 314225000744 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 314225000745 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 314225000746 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 314225000747 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 314225000748 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 314225000749 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 314225000750 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 314225000751 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 314225000752 S-adenosylmethionine binding site [chemical binding]; other site 314225000753 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 314225000754 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 314225000755 binding surface 314225000756 TPR motif; other site 314225000757 Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; pfam13759 314225000758 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 314225000759 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 314225000760 acetyl-CoA acetyltransferase; Provisional; Region: PRK06504 314225000761 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 314225000762 dimer interface [polypeptide binding]; other site 314225000763 active site 314225000764 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 314225000765 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 314225000766 NAD(P) binding site [chemical binding]; other site 314225000767 active site 314225000768 enoyl-CoA hydratase; Provisional; Region: PRK08260 314225000769 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 314225000770 substrate binding site [chemical binding]; other site 314225000771 oxyanion hole (OAH) forming residues; other site 314225000772 trimer interface [polypeptide binding]; other site 314225000773 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 314225000774 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 314225000775 MarR family; Region: MarR_2; pfam12802 314225000776 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 314225000777 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 314225000778 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 314225000779 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 314225000780 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 314225000781 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 314225000782 Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476 314225000783 Type IV pili component [Cell motility and secretion]; Region: COG5461 314225000784 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 314225000785 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 314225000786 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 314225000787 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 314225000788 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 314225000789 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 314225000790 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 314225000791 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 314225000792 hydroxyglutarate oxidase; Provisional; Region: PRK11728 314225000793 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 314225000794 Uncharacterized conserved protein [Function unknown]; Region: COG3422 314225000795 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 314225000796 RNA/DNA hybrid binding site [nucleotide binding]; other site 314225000797 active site 314225000798 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 314225000799 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 314225000800 putative active site [active] 314225000801 putative substrate binding site [chemical binding]; other site 314225000802 ATP binding site [chemical binding]; other site 314225000803 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 314225000804 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 314225000805 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 314225000806 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 314225000807 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 314225000808 active site 314225000809 HIGH motif; other site 314225000810 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 314225000811 KMSK motif region; other site 314225000812 tRNA binding surface [nucleotide binding]; other site 314225000813 DALR anticodon binding domain; Region: DALR_1; smart00836 314225000814 anticodon binding site; other site 314225000815 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 314225000816 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 314225000817 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 314225000818 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 314225000819 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 314225000820 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 314225000821 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 314225000822 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 314225000823 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 314225000824 active site 314225000825 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 314225000826 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 314225000827 threonine dehydratase; Provisional; Region: PRK07334 314225000828 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 314225000829 tetramer interface [polypeptide binding]; other site 314225000830 pyridoxal 5'-phosphate binding site [chemical binding]; other site 314225000831 catalytic residue [active] 314225000832 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 314225000833 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 314225000834 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 314225000835 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 314225000836 Surface antigen; Region: Bac_surface_Ag; pfam01103 314225000837 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 314225000838 Family of unknown function (DUF490); Region: DUF490; pfam04357 314225000839 Fasciclin domain; Region: Fasciclin; pfam02469 314225000840 glutamine synthetase; Provisional; Region: glnA; PRK09469 314225000841 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 314225000842 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 314225000843 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 314225000844 Nitrogen regulatory protein P-II; Region: P-II; smart00938 314225000845 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 314225000846 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 314225000847 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 314225000848 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 314225000849 interface (dimer of trimers) [polypeptide binding]; other site 314225000850 Substrate-binding/catalytic site; other site 314225000851 Zn-binding sites [ion binding]; other site 314225000852 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 314225000853 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 314225000854 active site 314225000855 CcmB protein; Region: CcmB; cl17444 314225000856 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 314225000857 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 314225000858 Walker A/P-loop; other site 314225000859 ATP binding site [chemical binding]; other site 314225000860 Q-loop/lid; other site 314225000861 ABC transporter signature motif; other site 314225000862 Walker B; other site 314225000863 D-loop; other site 314225000864 H-loop/switch region; other site 314225000865 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 314225000866 aromatic arch; other site 314225000867 DCoH dimer interaction site [polypeptide binding]; other site 314225000868 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 314225000869 DCoH tetramer interaction site [polypeptide binding]; other site 314225000870 substrate binding site [chemical binding]; other site 314225000871 short chain dehydrogenase; Provisional; Region: PRK08267 314225000872 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 314225000873 NAD(P) binding site [chemical binding]; other site 314225000874 active site 314225000875 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 314225000876 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 314225000877 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 314225000878 endonuclease III; Region: ENDO3c; smart00478 314225000879 minor groove reading motif; other site 314225000880 helix-hairpin-helix signature motif; other site 314225000881 active site 314225000882 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 314225000883 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 314225000884 catalytic loop [active] 314225000885 iron binding site [ion binding]; other site 314225000886 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 314225000887 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 314225000888 dimer interface [polypeptide binding]; other site 314225000889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 314225000890 catalytic residue [active] 314225000891 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 314225000892 cell division protein MraZ; Reviewed; Region: PRK00326 314225000893 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 314225000894 MraW methylase family; Region: Methyltransf_5; cl17771 314225000895 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 314225000896 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 314225000897 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 314225000898 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 314225000899 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 314225000900 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 314225000901 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 314225000902 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 314225000903 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 314225000904 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 314225000905 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 314225000906 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 314225000907 Mg++ binding site [ion binding]; other site 314225000908 putative catalytic motif [active] 314225000909 putative substrate binding site [chemical binding]; other site 314225000910 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 314225000911 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 314225000912 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 314225000913 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 314225000914 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 314225000915 active site 314225000916 homodimer interface [polypeptide binding]; other site 314225000917 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 314225000918 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 314225000919 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 314225000920 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 314225000921 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 314225000922 FAD binding domain; Region: FAD_binding_4; pfam01565 314225000923 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 314225000924 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 314225000925 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 314225000926 ATP-grasp domain; Region: ATP-grasp_4; cl17255 314225000927 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 314225000928 Cell division protein FtsQ; Region: FtsQ; pfam03799 314225000929 Cell division protein FtsA; Region: FtsA; smart00842 314225000930 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 314225000931 Cell division protein FtsA; Region: FtsA; pfam14450 314225000932 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 314225000933 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 314225000934 nucleotide binding site [chemical binding]; other site 314225000935 SulA interaction site; other site 314225000936 TPR repeat; Region: TPR_11; pfam13414 314225000937 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 314225000938 binding surface 314225000939 TPR motif; other site 314225000940 Sporulation related domain; Region: SPOR; pfam05036 314225000941 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 314225000942 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 314225000943 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 314225000944 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 314225000945 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 314225000946 GTPase CgtA; Reviewed; Region: obgE; PRK12299 314225000947 GTP1/OBG; Region: GTP1_OBG; pfam01018 314225000948 Obg GTPase; Region: Obg; cd01898 314225000949 G1 box; other site 314225000950 GTP/Mg2+ binding site [chemical binding]; other site 314225000951 Switch I region; other site 314225000952 G2 box; other site 314225000953 G3 box; other site 314225000954 Switch II region; other site 314225000955 G4 box; other site 314225000956 G5 box; other site 314225000957 gamma-glutamyl kinase; Provisional; Region: PRK05429 314225000958 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 314225000959 nucleotide binding site [chemical binding]; other site 314225000960 homotetrameric interface [polypeptide binding]; other site 314225000961 putative phosphate binding site [ion binding]; other site 314225000962 putative allosteric binding site; other site 314225000963 PUA domain; Region: PUA; cl00607 314225000964 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 314225000965 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 314225000966 putative NAD(P) binding site [chemical binding]; other site 314225000967 active site 314225000968 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 314225000969 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 314225000970 Active Sites [active] 314225000971 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 314225000972 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 314225000973 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 314225000974 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 314225000975 Protein of unknown function (DUF2849); Region: DUF2849; pfam11011 314225000976 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 314225000977 active site 314225000978 SAM binding site [chemical binding]; other site 314225000979 homodimer interface [polypeptide binding]; other site 314225000980 Mechanosensitive ion channel; Region: MS_channel; pfam00924 314225000981 cystathionine beta-lyase; Provisional; Region: PRK09028 314225000982 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 314225000983 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 314225000984 catalytic residue [active] 314225000985 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 314225000986 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 314225000987 active site residue [active] 314225000988 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 314225000989 active site residue [active] 314225000990 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 314225000991 Domain of unknown function (DUF4403); Region: DUF4403; pfam14356 314225000992 recombination factor protein RarA; Reviewed; Region: PRK13342 314225000993 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 314225000994 Walker A motif; other site 314225000995 ATP binding site [chemical binding]; other site 314225000996 Walker B motif; other site 314225000997 arginine finger; other site 314225000998 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 314225000999 Predicted transcriptional regulators [Transcription]; Region: COG1695 314225001000 Transcriptional regulator PadR-like family; Region: PadR; cl17335 314225001001 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 314225001002 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 314225001003 phosphoserine aminotransferase; Provisional; Region: PRK03080 314225001004 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 314225001005 catalytic residue [active] 314225001006 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 314225001007 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 314225001008 ligand binding site [chemical binding]; other site 314225001009 NAD binding site [chemical binding]; other site 314225001010 dimerization interface [polypeptide binding]; other site 314225001011 catalytic site [active] 314225001012 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 314225001013 putative L-serine binding site [chemical binding]; other site 314225001014 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 314225001015 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 314225001016 motif 1; other site 314225001017 dimer interface [polypeptide binding]; other site 314225001018 active site 314225001019 motif 2; other site 314225001020 motif 3; other site 314225001021 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 314225001022 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 314225001023 active site 314225001024 catalytic tetrad [active] 314225001025 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 314225001026 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 314225001027 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 314225001028 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 314225001029 GDP-binding site [chemical binding]; other site 314225001030 ACT binding site; other site 314225001031 IMP binding site; other site 314225001032 acyl-CoA synthetase; Validated; Region: PRK07798 314225001033 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 314225001034 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 314225001035 acyl-activating enzyme (AAE) consensus motif; other site 314225001036 acyl-activating enzyme (AAE) consensus motif; other site 314225001037 putative AMP binding site [chemical binding]; other site 314225001038 putative active site [active] 314225001039 putative CoA binding site [chemical binding]; other site 314225001040 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 314225001041 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 314225001042 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 314225001043 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 314225001044 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 314225001045 diaminopimelate decarboxylase; Region: lysA; TIGR01048 314225001046 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 314225001047 active site 314225001048 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 314225001049 substrate binding site [chemical binding]; other site 314225001050 catalytic residues [active] 314225001051 dimer interface [polypeptide binding]; other site 314225001052 argininosuccinate lyase; Provisional; Region: PRK00855 314225001053 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 314225001054 active sites [active] 314225001055 tetramer interface [polypeptide binding]; other site 314225001056 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 314225001057 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 314225001058 catalytic residues [active] 314225001059 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 314225001060 Methyltransferase domain; Region: Methyltransf_11; pfam08241 314225001061 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 314225001062 active site 314225001063 homodimer interface [polypeptide binding]; other site 314225001064 homotetramer interface [polypeptide binding]; other site 314225001065 2-enoyl thioester reductase (ETR) like proteins, child 1; Region: ETR_like_1; cd08291 314225001066 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 314225001067 NADP binding site [chemical binding]; other site 314225001068 dimer interface [polypeptide binding]; other site 314225001069 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 314225001070 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 314225001071 dimerization interface 3.5A [polypeptide binding]; other site 314225001072 active site 314225001073 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 314225001074 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 314225001075 putative active site [active] 314225001076 substrate binding site [chemical binding]; other site 314225001077 putative cosubstrate binding site; other site 314225001078 catalytic site [active] 314225001079 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 314225001080 substrate binding site [chemical binding]; other site 314225001081 recombination protein RecR; Reviewed; Region: recR; PRK00076 314225001082 RecR protein; Region: RecR; pfam02132 314225001083 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 314225001084 putative active site [active] 314225001085 putative metal-binding site [ion binding]; other site 314225001086 tetramer interface [polypeptide binding]; other site 314225001087 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 314225001088 active site 314225001089 catalytic residues [active] 314225001090 metal binding site [ion binding]; metal-binding site 314225001091 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 314225001092 dimerization interface [polypeptide binding]; other site 314225001093 RmuC family; Region: RmuC; pfam02646 314225001094 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 314225001095 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 314225001096 ligand binding site [chemical binding]; other site 314225001097 flexible hinge region; other site 314225001098 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 314225001099 putative switch regulator; other site 314225001100 non-specific DNA interactions [nucleotide binding]; other site 314225001101 DNA binding site [nucleotide binding] 314225001102 sequence specific DNA binding site [nucleotide binding]; other site 314225001103 putative cAMP binding site [chemical binding]; other site 314225001104 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 314225001105 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 314225001106 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 314225001107 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 314225001108 dimerization domain swap beta strand [polypeptide binding]; other site 314225001109 regulatory protein interface [polypeptide binding]; other site 314225001110 active site 314225001111 regulatory phosphorylation site [posttranslational modification]; other site 314225001112 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 314225001113 active pocket/dimerization site; other site 314225001114 active site 314225001115 phosphorylation site [posttranslational modification] 314225001116 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 314225001117 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 314225001118 Hpr binding site; other site 314225001119 active site 314225001120 homohexamer subunit interaction site [polypeptide binding]; other site 314225001121 Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755 314225001122 Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756 314225001123 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 314225001124 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 314225001125 dimerization interface [polypeptide binding]; other site 314225001126 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 314225001127 dimer interface [polypeptide binding]; other site 314225001128 phosphorylation site [posttranslational modification] 314225001129 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 314225001130 ATP binding site [chemical binding]; other site 314225001131 Mg2+ binding site [ion binding]; other site 314225001132 G-X-G motif; other site 314225001133 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 314225001134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 314225001135 active site 314225001136 phosphorylation site [posttranslational modification] 314225001137 intermolecular recognition site; other site 314225001138 dimerization interface [polypeptide binding]; other site 314225001139 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 314225001140 DNA binding site [nucleotide binding] 314225001141 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 314225001142 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 314225001143 active site 314225001144 substrate-binding site [chemical binding]; other site 314225001145 metal-binding site [ion binding] 314225001146 ATP binding site [chemical binding]; other site 314225001147 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 314225001148 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 314225001149 ligand binding site [chemical binding]; other site 314225001150 flexible hinge region; other site 314225001151 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 314225001152 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 314225001153 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 314225001154 Domain of unknown function (DUF3597); Region: DUF3597; pfam12200 314225001155 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 314225001156 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 314225001157 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 314225001158 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 314225001159 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 314225001160 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 314225001161 catalytic residue [active] 314225001162 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 314225001163 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 314225001164 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 314225001165 catalytic residue [active] 314225001166 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 314225001167 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 314225001168 catalytic loop [active] 314225001169 iron binding site [ion binding]; other site 314225001170 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 314225001171 DNA binding residues [nucleotide binding] 314225001172 dimerization interface [polypeptide binding]; other site 314225001173 Predicted membrane protein [Function unknown]; Region: COG3817 314225001174 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 314225001175 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 314225001176 intracellular protease, PfpI family; Region: PfpI; TIGR01382 314225001177 proposed catalytic triad [active] 314225001178 conserved cys residue [active] 314225001179 translocation protein TolB; Provisional; Region: tolB; PRK04043 314225001180 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 314225001181 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 314225001182 CAP-like domain; other site 314225001183 active site 314225001184 primary dimer interface [polypeptide binding]; other site 314225001185 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 314225001186 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 314225001187 active site 314225001188 NTP binding site [chemical binding]; other site 314225001189 metal binding triad [ion binding]; metal-binding site 314225001190 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 314225001191 putative active site [active] 314225001192 putative CoA binding site [chemical binding]; other site 314225001193 nudix motif; other site 314225001194 metal binding site [ion binding]; metal-binding site 314225001195 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 314225001196 Predicted acetyltransferase [General function prediction only]; Region: COG3153 314225001197 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 314225001198 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 314225001199 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 314225001200 RNA/DNA hybrid binding site [nucleotide binding]; other site 314225001201 active site 314225001202 short chain dehydrogenase; Provisional; Region: PRK06197 314225001203 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 314225001204 putative NAD(P) binding site [chemical binding]; other site 314225001205 active site 314225001206 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 314225001207 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 314225001208 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 314225001209 dimerization interface [polypeptide binding]; other site 314225001210 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 314225001211 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 314225001212 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 314225001213 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 314225001214 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 314225001215 DNA methylase; Region: N6_N4_Mtase; pfam01555 314225001216 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 314225001217 Beta-lactamase; Region: Beta-lactamase; pfam00144 314225001218 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 314225001219 dihydropteroate synthase; Region: DHPS; TIGR01496 314225001220 substrate binding pocket [chemical binding]; other site 314225001221 dimer interface [polypeptide binding]; other site 314225001222 inhibitor binding site; inhibition site 314225001223 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 314225001224 putative active site [active] 314225001225 putative metal binding site [ion binding]; other site 314225001226 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 314225001227 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 314225001228 NAD(P) binding site [chemical binding]; other site 314225001229 active site 314225001230 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 314225001231 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 314225001232 active site 314225001233 phosphorylation site [posttranslational modification] 314225001234 intermolecular recognition site; other site 314225001235 dimerization interface [polypeptide binding]; other site 314225001236 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 314225001237 Walker A motif; other site 314225001238 ATP binding site [chemical binding]; other site 314225001239 Walker B motif; other site 314225001240 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 314225001241 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 314225001242 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 314225001243 ligand binding site [chemical binding]; other site 314225001244 homodimer interface [polypeptide binding]; other site 314225001245 NAD(P) binding site [chemical binding]; other site 314225001246 trimer interface B [polypeptide binding]; other site 314225001247 trimer interface A [polypeptide binding]; other site 314225001248 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 314225001249 Fasciclin domain; Region: Fasciclin; pfam02469 314225001250 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 314225001251 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 314225001252 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 314225001253 parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805 314225001254 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 314225001255 conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806 314225001256 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 314225001257 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 314225001258 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 314225001259 aspartate racemase; Region: asp_race; TIGR00035 314225001260 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 314225001261 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 314225001262 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 314225001263 Zn2+ binding site [ion binding]; other site 314225001264 Mg2+ binding site [ion binding]; other site 314225001265 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 314225001266 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 314225001267 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 314225001268 NAD(P) binding site [chemical binding]; other site 314225001269 active site 314225001270 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 314225001271 Entericidin EcnA/B family; Region: Entericidin; cl02322 314225001272 Entericidin EcnA/B family; Region: Entericidin; cl02322 314225001273 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 314225001274 EamA-like transporter family; Region: EamA; pfam00892 314225001275 EamA-like transporter family; Region: EamA; cl17759 314225001276 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 314225001277 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 314225001278 ATP binding site [chemical binding]; other site 314225001279 Walker A motif; other site 314225001280 hexamer interface [polypeptide binding]; other site 314225001281 Walker B motif; other site 314225001282 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 314225001283 oligomeric interface; other site 314225001284 putative active site [active] 314225001285 homodimer interface [polypeptide binding]; other site 314225001286 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 314225001287 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 314225001288 glutaminase active site [active] 314225001289 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 314225001290 dimer interface [polypeptide binding]; other site 314225001291 active site 314225001292 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 314225001293 dimer interface [polypeptide binding]; other site 314225001294 active site 314225001295 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 314225001296 PAS domain; Region: PAS_9; pfam13426 314225001297 putative active site [active] 314225001298 heme pocket [chemical binding]; other site 314225001299 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 314225001300 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 314225001301 metal binding site [ion binding]; metal-binding site 314225001302 active site 314225001303 I-site; other site 314225001304 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 314225001305 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 314225001306 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 314225001307 putative active site [active] 314225001308 catalytic triad [active] 314225001309 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 314225001310 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 314225001311 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 314225001312 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 314225001313 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 314225001314 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 314225001315 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 314225001316 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 314225001317 ATP binding site [chemical binding]; other site 314225001318 active site 314225001319 substrate binding site [chemical binding]; other site 314225001320 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 314225001321 AAA domain; Region: AAA_17; pfam13207 314225001322 Domain of unknown function (DUF329); Region: DUF329; cl01144 314225001323 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 314225001324 Maf-like protein; Provisional; Region: PRK14361 314225001325 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 314225001326 active site 314225001327 dimer interface [polypeptide binding]; other site 314225001328 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 314225001329 rRNA binding site [nucleotide binding]; other site 314225001330 predicted 30S ribosome binding site; other site 314225001331 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 314225001332 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 314225001333 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 314225001334 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 314225001335 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14671 314225001336 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 314225001337 GIY-YIG motif/motif A; other site 314225001338 active site 314225001339 catalytic site [active] 314225001340 putative DNA binding site [nucleotide binding]; other site 314225001341 metal binding site [ion binding]; metal-binding site 314225001342 UvrB/uvrC motif; Region: UVR; pfam02151 314225001343 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 314225001344 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 314225001345 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 314225001346 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 314225001347 ligand binding site [chemical binding]; other site 314225001348 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 314225001349 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 314225001350 active site 314225001351 phosphorylation site [posttranslational modification] 314225001352 intermolecular recognition site; other site 314225001353 dimerization interface [polypeptide binding]; other site 314225001354 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 314225001355 DNA binding site [nucleotide binding] 314225001356 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 314225001357 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 314225001358 dimer interface [polypeptide binding]; other site 314225001359 phosphorylation site [posttranslational modification] 314225001360 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 314225001361 ATP binding site [chemical binding]; other site 314225001362 Mg2+ binding site [ion binding]; other site 314225001363 G-X-G motif; other site 314225001364 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_3; cd13148 314225001365 putative efflux protein, MATE family; Region: matE; TIGR00797 314225001366 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 314225001367 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 314225001368 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 314225001369 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 314225001370 active site 314225001371 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 314225001372 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 314225001373 catalytic triad [active] 314225001374 dimer interface [polypeptide binding]; other site 314225001375 Cupin-like domain; Region: Cupin_8; pfam13621 314225001376 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 314225001377 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 314225001378 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 314225001379 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 314225001380 Fatty acid desaturase; Region: FA_desaturase; pfam00487 314225001381 putative di-iron ligands [ion binding]; other site 314225001382 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 314225001383 thiamine-monophosphate kinase; Region: thiL; TIGR01379 314225001384 ATP binding site [chemical binding]; other site 314225001385 dimerization interface [polypeptide binding]; other site 314225001386 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 314225001387 histidinol dehydrogenase; Region: hisD; TIGR00069 314225001388 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 314225001389 NAD binding site [chemical binding]; other site 314225001390 dimerization interface [polypeptide binding]; other site 314225001391 product binding site; other site 314225001392 substrate binding site [chemical binding]; other site 314225001393 zinc binding site [ion binding]; other site 314225001394 catalytic residues [active] 314225001395 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 314225001396 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 314225001397 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 314225001398 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 314225001399 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs; Region: 11beta-HSD1_like_SDR_c; cd05332 314225001400 short chain dehydrogenase; Provisional; Region: PRK06181 314225001401 NADP binding site [chemical binding]; other site 314225001402 homodimer interface [polypeptide binding]; other site 314225001403 substrate binding site [chemical binding]; other site 314225001404 active site 314225001405 Pirin-related protein [General function prediction only]; Region: COG1741 314225001406 Pirin; Region: Pirin; pfam02678 314225001407 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 314225001408 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 314225001409 nudix motif; other site 314225001410 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 314225001411 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 314225001412 HSP70 interaction site [polypeptide binding]; other site 314225001413 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 314225001414 dimer interface [polypeptide binding]; other site 314225001415 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 314225001416 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 314225001417 putative C-terminal domain interface [polypeptide binding]; other site 314225001418 putative GSH binding site (G-site) [chemical binding]; other site 314225001419 putative dimer interface [polypeptide binding]; other site 314225001420 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 314225001421 dimer interface [polypeptide binding]; other site 314225001422 N-terminal domain interface [polypeptide binding]; other site 314225001423 putative substrate binding pocket (H-site) [chemical binding]; other site 314225001424 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 314225001425 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 314225001426 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 314225001427 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 314225001428 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 314225001429 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 314225001430 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 314225001431 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 314225001432 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 314225001433 Transglycosylase; Region: Transgly; pfam00912 314225001434 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 314225001435 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 314225001436 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 314225001437 CoenzymeA binding site [chemical binding]; other site 314225001438 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 314225001439 subunit interaction site [polypeptide binding]; other site 314225001440 PHB binding site; other site 314225001441 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 314225001442 CoenzymeA binding site [chemical binding]; other site 314225001443 subunit interaction site [polypeptide binding]; other site 314225001444 PHB binding site; other site 314225001445 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 314225001446 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 314225001447 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 314225001448 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 314225001449 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 314225001450 Catalytic site [active] 314225001451 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 314225001452 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 314225001453 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 314225001454 active site 314225001455 hydrophilic channel; other site 314225001456 dimerization interface [polypeptide binding]; other site 314225001457 catalytic residues [active] 314225001458 active site lid [active] 314225001459 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 314225001460 active site 314225001461 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140 314225001462 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 314225001463 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 314225001464 cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007 314225001465 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 314225001466 Subunit I/III interface [polypeptide binding]; other site 314225001467 D-pathway; other site 314225001468 Subunit I/VIIc interface [polypeptide binding]; other site 314225001469 Subunit I/IV interface [polypeptide binding]; other site 314225001470 Subunit I/II interface [polypeptide binding]; other site 314225001471 Low-spin heme (heme a) binding site [chemical binding]; other site 314225001472 Subunit I/VIIa interface [polypeptide binding]; other site 314225001473 Subunit I/VIa interface [polypeptide binding]; other site 314225001474 Dimer interface; other site 314225001475 Putative water exit pathway; other site 314225001476 Binuclear center (heme a3/CuB) [ion binding]; other site 314225001477 K-pathway; other site 314225001478 Subunit I/Vb interface [polypeptide binding]; other site 314225001479 Putative proton exit pathway; other site 314225001480 Subunit I/VIb interface; other site 314225001481 Subunit I/VIc interface [polypeptide binding]; other site 314225001482 Electron transfer pathway; other site 314225001483 Subunit I/VIIIb interface [polypeptide binding]; other site 314225001484 Subunit I/VIIb interface [polypeptide binding]; other site 314225001485 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 314225001486 UbiA prenyltransferase family; Region: UbiA; pfam01040 314225001487 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 314225001488 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 314225001489 Subunit III/VIIa interface [polypeptide binding]; other site 314225001490 Phospholipid binding site [chemical binding]; other site 314225001491 Subunit I/III interface [polypeptide binding]; other site 314225001492 Subunit III/VIb interface [polypeptide binding]; other site 314225001493 Subunit III/VIa interface; other site 314225001494 Subunit III/Vb interface [polypeptide binding]; other site 314225001495 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 314225001496 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 314225001497 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 314225001498 pyridoxal 5'-phosphate binding site [chemical binding]; other site 314225001499 catalytic residue [active] 314225001500 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 314225001501 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 314225001502 S-adenosylmethionine binding site [chemical binding]; other site 314225001503 Dihydroneopterin aldolase; Region: FolB; pfam02152 314225001504 active site 314225001505 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 314225001506 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 314225001507 FeS/SAM binding site; other site 314225001508 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 314225001509 Ubiquitin-like proteins; Region: UBQ; cl00155 314225001510 charged pocket; other site 314225001511 hydrophobic patch; other site 314225001512 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 314225001513 MoaE homodimer interface [polypeptide binding]; other site 314225001514 MoaD interaction [polypeptide binding]; other site 314225001515 active site residues [active] 314225001516 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 314225001517 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 314225001518 ligand binding site [chemical binding]; other site 314225001519 flexible hinge region; other site 314225001520 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 314225001521 putative switch regulator; other site 314225001522 non-specific DNA interactions [nucleotide binding]; other site 314225001523 DNA binding site [nucleotide binding] 314225001524 sequence specific DNA binding site [nucleotide binding]; other site 314225001525 putative cAMP binding site [chemical binding]; other site 314225001526 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 314225001527 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 314225001528 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 314225001529 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 314225001530 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 314225001531 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 314225001532 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 314225001533 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 314225001534 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 314225001535 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 314225001536 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 314225001537 Patatin-like phospholipase; Region: Patatin; pfam01734 314225001538 ATP-grasp domain; Region: ATP-grasp_4; cl17255 314225001539 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 314225001540 active site 314225001541 substrate binding pocket [chemical binding]; other site 314225001542 dimer interface [polypeptide binding]; other site 314225001543 Predicted permeases [General function prediction only]; Region: RarD; COG2962 314225001544 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 314225001545 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 314225001546 NAD(P) binding site [chemical binding]; other site 314225001547 catalytic residues [active] 314225001548 hypothetical protein; Validated; Region: PRK00029 314225001549 Uncharacterized conserved protein [Function unknown]; Region: COG0397 314225001550 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 314225001551 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 314225001552 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 314225001553 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 314225001554 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 314225001555 Trp docking motif [polypeptide binding]; other site 314225001556 active site 314225001557 PQQ-like domain; Region: PQQ_2; pfam13360 314225001558 PQQ-like domain; Region: PQQ_2; pfam13360 314225001559 Phospholipid methyltransferase; Region: PEMT; cl17370 314225001560 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 314225001561 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 314225001562 Uncharacterized conserved protein [Function unknown]; Region: COG1359 314225001563 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 314225001564 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 314225001565 RNA methyltransferase, RsmE family; Region: TIGR00046 314225001566 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878 314225001567 UbiA prenyltransferase family; Region: UbiA; pfam01040 314225001568 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 314225001569 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 314225001570 catalytic core [active] 314225001571 Domain of unknown function (DUF4402); Region: DUF4402; pfam14352 314225001572 Domain of unknown function (DUF4402); Region: DUF4402; pfam14352 314225001573 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 314225001574 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 314225001575 DNA binding residues [nucleotide binding] 314225001576 dimer interface [polypeptide binding]; other site 314225001577 [2Fe-2S] cluster binding site [ion binding]; other site 314225001578 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 314225001579 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 314225001580 active site 314225001581 metal binding site [ion binding]; metal-binding site 314225001582 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 314225001583 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 314225001584 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 314225001585 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 314225001586 active site 314225001587 nucleotide binding site [chemical binding]; other site 314225001588 HIGH motif; other site 314225001589 KMSKS motif; other site 314225001590 hypothetical protein; Provisional; Region: PRK13559 314225001591 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 314225001592 putative active site [active] 314225001593 heme pocket [chemical binding]; other site 314225001594 HWE histidine kinase; Region: HWE_HK; smart00911 314225001595 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 314225001596 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 314225001597 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 314225001598 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 314225001599 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 314225001600 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 314225001601 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 314225001602 ATP binding site [chemical binding]; other site 314225001603 putative Mg++ binding site [ion binding]; other site 314225001604 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 314225001605 nucleotide binding region [chemical binding]; other site 314225001606 ATP-binding site [chemical binding]; other site 314225001607 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 314225001608 RNA binding site [nucleotide binding]; other site 314225001609 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 314225001610 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 314225001611 Walker A/P-loop; other site 314225001612 ATP binding site [chemical binding]; other site 314225001613 Q-loop/lid; other site 314225001614 ABC transporter signature motif; other site 314225001615 Walker B; other site 314225001616 D-loop; other site 314225001617 H-loop/switch region; other site 314225001618 ABC transporter; Region: ABC_tran_2; pfam12848 314225001619 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 314225001620 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 314225001621 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 314225001622 metal binding site [ion binding]; metal-binding site 314225001623 active site 314225001624 I-site; other site 314225001625 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 314225001626 PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815 314225001627 PA/protease or protease-like domain interface [polypeptide binding]; other site 314225001628 M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883 314225001629 Peptidase family M28; Region: Peptidase_M28; pfam04389 314225001630 metal binding site [ion binding]; metal-binding site 314225001631 RNA polymerase sigma factor; Provisional; Region: PRK12547 314225001632 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 314225001633 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 314225001634 DNA binding residues [nucleotide binding] 314225001635 Peptidase S8 family domain, uncharacterized subfamily 4; Region: Peptidases_S8_4; cd05561 314225001636 active site 314225001637 catalytic triad [active] 314225001638 Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935 314225001639 putative active site [active] 314225001640 putative catalytic site [active] 314225001641 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 314225001642 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 314225001643 phosphorylation site [posttranslational modification] 314225001644 dimer interface [polypeptide binding]; other site 314225001645 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 314225001646 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 314225001647 putative DNA binding site [nucleotide binding]; other site 314225001648 putative Zn2+ binding site [ion binding]; other site 314225001649 AsnC family; Region: AsnC_trans_reg; pfam01037 314225001650 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 314225001651 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 314225001652 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 314225001653 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 314225001654 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 314225001655 carboxyltransferase (CT) interaction site; other site 314225001656 biotinylation site [posttranslational modification]; other site 314225001657 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 314225001658 Dehydroquinase class II; Region: DHquinase_II; pfam01220 314225001659 trimer interface [polypeptide binding]; other site 314225001660 active site 314225001661 dimer interface [polypeptide binding]; other site 314225001662 Protein of unknown function (DUF3154); Region: DUF3154; pfam11351 314225001663 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 314225001664 putative active site [active] 314225001665 putative catalytic site [active] 314225001666 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 314225001667 GIY-YIG motif/motif A; other site 314225001668 putative active site [active] 314225001669 putative metal binding site [ion binding]; other site 314225001670 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 314225001671 Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313 314225001672 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 314225001673 active site 314225001674 catalytic site [active] 314225001675 GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301 314225001676 Transcriptional regulators [Transcription]; Region: PurR; COG1609 314225001677 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 314225001678 DNA binding site [nucleotide binding] 314225001679 domain linker motif; other site 314225001680 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 314225001681 putative dimerization interface [polypeptide binding]; other site 314225001682 putative ligand binding site [chemical binding]; other site 314225001683 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 314225001684 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 314225001685 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 314225001686 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 314225001687 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 314225001688 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 314225001689 active site 314225001690 catalytic site [active] 314225001691 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 314225001692 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 314225001693 active site 314225001694 catalytic site [active] 314225001695 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 314225001696 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 314225001697 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 314225001698 Transcriptional regulators [Transcription]; Region: PurR; COG1609 314225001699 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 314225001700 DNA binding site [nucleotide binding] 314225001701 domain linker motif; other site 314225001702 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 314225001703 putative dimerization interface [polypeptide binding]; other site 314225001704 putative ligand binding site [chemical binding]; other site 314225001705 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 314225001706 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 314225001707 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 314225001708 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 314225001709 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 314225001710 N-acetyl-D-glucosamine binding site [chemical binding]; other site 314225001711 catalytic residue [active] 314225001712 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 314225001713 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 314225001714 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 314225001715 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 314225001716 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 314225001717 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 314225001718 VirB7 interaction site; other site 314225001719 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 314225001720 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 314225001721 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 314225001722 Walker A motif; other site 314225001723 hexamer interface [polypeptide binding]; other site 314225001724 ATP binding site [chemical binding]; other site 314225001725 Walker B motif; other site 314225001726 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 314225001727 polyphosphate kinase 1; Region: poly_P_kin; TIGR03705 314225001728 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 314225001729 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 314225001730 putative domain interface [polypeptide binding]; other site 314225001731 putative active site [active] 314225001732 catalytic site [active] 314225001733 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 314225001734 putative active site [active] 314225001735 catalytic site [active] 314225001736 exopolyphosphatase; Region: exo_poly_only; TIGR03706 314225001737 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 314225001738 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 314225001739 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 314225001740 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 314225001741 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 314225001742 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 314225001743 nudix motif; other site 314225001744 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 314225001745 putative GSH binding site [chemical binding]; other site 314225001746 catalytic residues [active] 314225001747 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 314225001748 Domain of unknown function (DUF1476); Region: DUF1476; pfam07345 314225001749 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 314225001750 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 314225001751 NAD(P) binding site [chemical binding]; other site 314225001752 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 314225001753 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 314225001754 substrate binding site [chemical binding]; other site 314225001755 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 314225001756 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 314225001757 substrate binding site [chemical binding]; other site 314225001758 ligand binding site [chemical binding]; other site 314225001759 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 314225001760 active site 314225001761 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 314225001762 Fatty acid desaturase; Region: FA_desaturase; pfam00487 314225001763 putative di-iron ligands [ion binding]; other site 314225001764 beta-carotene hydroxylase; Region: PLN02601 314225001765 Proteolipid membrane potential modulator; Region: Pmp3; cl00431 314225001766 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 314225001767 Fe-S metabolism associated domain; Region: SufE; cl00951 314225001768 phage shock protein C; Region: phageshock_pspC; TIGR02978 314225001769 phage shock protein C; Region: phageshock_pspC; TIGR02978 314225001770 PspC domain; Region: PspC; pfam04024 314225001771 phage shock protein B; Region: phageshock_pspB; TIGR02976 314225001772 phage shock protein A; Region: phageshock_pspA; TIGR02977 314225001773 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 314225001774 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 314225001775 Walker A motif; other site 314225001776 ATP binding site [chemical binding]; other site 314225001777 Walker B motif; other site 314225001778 arginine finger; other site 314225001779 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 314225001780 PemK-like protein; Region: PemK; pfam02452 314225001781 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 314225001782 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 314225001783 hypothetical protein; Provisional; Region: PRK14636 314225001784 Sm and related proteins; Region: Sm_like; cl00259 314225001785 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 314225001786 putative oligomer interface [polypeptide binding]; other site 314225001787 putative RNA binding site [nucleotide binding]; other site 314225001788 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 314225001789 NusA N-terminal domain; Region: NusA_N; pfam08529 314225001790 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 314225001791 RNA binding site [nucleotide binding]; other site 314225001792 homodimer interface [polypeptide binding]; other site 314225001793 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 314225001794 G-X-X-G motif; other site 314225001795 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 314225001796 G-X-X-G motif; other site 314225001797 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 314225001798 hypothetical protein; Provisional; Region: PRK09190 314225001799 Protein of unknown function (DUF448); Region: DUF448; pfam04296 314225001800 putative RNA binding cleft [nucleotide binding]; other site 314225001801 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 314225001802 translation initiation factor IF-2; Region: IF-2; TIGR00487 314225001803 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 314225001804 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 314225001805 G1 box; other site 314225001806 putative GEF interaction site [polypeptide binding]; other site 314225001807 GTP/Mg2+ binding site [chemical binding]; other site 314225001808 Switch I region; other site 314225001809 G2 box; other site 314225001810 G3 box; other site 314225001811 Switch II region; other site 314225001812 G4 box; other site 314225001813 G5 box; other site 314225001814 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 314225001815 Translation-initiation factor 2; Region: IF-2; pfam11987 314225001816 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 314225001817 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 314225001818 CoenzymeA binding site [chemical binding]; other site 314225001819 subunit interaction site [polypeptide binding]; other site 314225001820 PHB binding site; other site 314225001821 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 314225001822 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 314225001823 enoyl-CoA hydratase; Provisional; Region: PRK08290 314225001824 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 314225001825 substrate binding site [chemical binding]; other site 314225001826 oxyanion hole (OAH) forming residues; other site 314225001827 trimer interface [polypeptide binding]; other site 314225001828 haloalkane dehalogenase; Provisional; Region: PRK00870 314225001829 YceI-like domain; Region: YceI; pfam04264 314225001830 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 314225001831 AbgT putative transporter family; Region: ABG_transport; cl17431 314225001832 thymidine kinase; Provisional; Region: PRK04296 314225001833 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 314225001834 Peptidase family M50; Region: Peptidase_M50; pfam02163 314225001835 active site 314225001836 putative substrate binding region [chemical binding]; other site 314225001837 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 314225001838 galactokinase; Region: gal_kin; TIGR00131 314225001839 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 314225001840 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 314225001841 nucleotide binding site/active site [active] 314225001842 HIT family signature motif; other site 314225001843 catalytic residue [active] 314225001844 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 314225001845 Melibiase; Region: Melibiase; pfam02065 314225001846 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 314225001847 Na binding site [ion binding]; other site 314225001848 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 314225001849 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 314225001850 RNA binding site [nucleotide binding]; other site 314225001851 active site 314225001852 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 314225001853 16S/18S rRNA binding site [nucleotide binding]; other site 314225001854 S13e-L30e interaction site [polypeptide binding]; other site 314225001855 25S rRNA binding site [nucleotide binding]; other site 314225001856 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 314225001857 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 314225001858 RNase E interface [polypeptide binding]; other site 314225001859 trimer interface [polypeptide binding]; other site 314225001860 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 314225001861 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 314225001862 RNase E interface [polypeptide binding]; other site 314225001863 trimer interface [polypeptide binding]; other site 314225001864 active site 314225001865 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 314225001866 putative nucleic acid binding region [nucleotide binding]; other site 314225001867 G-X-X-G motif; other site 314225001868 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 314225001869 RNA binding site [nucleotide binding]; other site 314225001870 domain interface; other site 314225001871 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 314225001872 Protein of unknown function, DUF481; Region: DUF481; pfam04338 314225001873 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 314225001874 GcrA cell cycle regulator; Region: GcrA; cl11564 314225001875 GcrA cell cycle regulator; Region: GcrA; cl11564 314225001876 ABC-2 type transporter; Region: ABC2_membrane; cl17235 314225001877 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 314225001878 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755 314225001879 glutamate dehydrogenase; Provisional; Region: PRK09414 314225001880 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 314225001881 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 314225001882 NAD(P) binding site [chemical binding]; other site 314225001883 Protein of unknown function, DUF393; Region: DUF393; pfam04134 314225001884 putative transporter; Provisional; Region: PRK10484 314225001885 Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; Region: SLC5sbd_vSGLT; cd10325 314225001886 Na binding site [ion binding]; other site 314225001887 substrate binding site [chemical binding]; other site 314225001888 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 314225001889 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 314225001890 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 314225001891 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 314225001892 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 314225001893 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 314225001894 Protein export membrane protein; Region: SecD_SecF; pfam02355 314225001895 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 314225001896 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 314225001897 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 314225001898 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 314225001899 non-specific DNA binding site [nucleotide binding]; other site 314225001900 salt bridge; other site 314225001901 sequence-specific DNA binding site [nucleotide binding]; other site 314225001902 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 314225001903 putative uracil binding site [chemical binding]; other site 314225001904 putative active site [active] 314225001905 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 314225001906 ABC transporter ATPase component; Reviewed; Region: PRK11147 314225001907 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 314225001908 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 314225001909 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 314225001910 Amidohydrolase; Region: Amidohydro_4; pfam13147 314225001911 active site 314225001912 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 314225001913 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 314225001914 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 314225001915 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 314225001916 active site 314225001917 phosphorylation site [posttranslational modification] 314225001918 intermolecular recognition site; other site 314225001919 dimerization interface [polypeptide binding]; other site 314225001920 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 314225001921 DNA binding site [nucleotide binding] 314225001922 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 314225001923 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 314225001924 ATP binding site [chemical binding]; other site 314225001925 Mg2+ binding site [ion binding]; other site 314225001926 G-X-G motif; other site 314225001927 chorismate mutase; Provisional; Region: PRK09239 314225001928 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 314225001929 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 314225001930 substrate binding pocket [chemical binding]; other site 314225001931 chain length determination region; other site 314225001932 substrate-Mg2+ binding site; other site 314225001933 catalytic residues [active] 314225001934 aspartate-rich region 1; other site 314225001935 active site lid residues [active] 314225001936 aspartate-rich region 2; other site 314225001937 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 314225001938 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 314225001939 ATP binding site [chemical binding]; other site 314225001940 putative Mg++ binding site [ion binding]; other site 314225001941 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 314225001942 nucleotide binding region [chemical binding]; other site 314225001943 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 314225001944 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 314225001945 DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111 314225001946 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 314225001947 Walker A motif; other site 314225001948 ATP binding site [chemical binding]; other site 314225001949 Walker B motif; other site 314225001950 arginine finger; other site 314225001951 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 314225001952 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 314225001953 hypothetical protein; Validated; Region: PRK00153 314225001954 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 314225001955 Found in ATP-dependent protease La (LON); Region: LON; smart00464 314225001956 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 314225001957 Walker A motif; other site 314225001958 ATP binding site [chemical binding]; other site 314225001959 Walker B motif; other site 314225001960 arginine finger; other site 314225001961 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 314225001962 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 314225001963 IHF dimer interface [polypeptide binding]; other site 314225001964 IHF - DNA interface [nucleotide binding]; other site 314225001965 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 314225001966 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 314225001967 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 314225001968 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 314225001969 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 314225001970 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 314225001971 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 314225001972 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 314225001973 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 314225001974 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 314225001975 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 314225001976 active site 314225001977 catalytic tetrad [active] 314225001978 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 314225001979 active site 314225001980 iron coordination sites [ion binding]; other site 314225001981 substrate binding pocket [chemical binding]; other site 314225001982 putative transporter; Provisional; Region: PRK10484 314225001983 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 314225001984 Na binding site [ion binding]; other site 314225001985 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 314225001986 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 314225001987 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 314225001988 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 314225001989 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 314225001990 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 314225001991 dimer interface [polypeptide binding]; other site 314225001992 active site 314225001993 CoA binding pocket [chemical binding]; other site 314225001994 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 314225001995 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 314225001996 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 314225001997 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 314225001998 rRNA interaction site [nucleotide binding]; other site 314225001999 S8 interaction site; other site 314225002000 putative laminin-1 binding site; other site 314225002001 elongation factor Ts; Provisional; Region: tsf; PRK09377 314225002002 UBA/TS-N domain; Region: UBA; pfam00627 314225002003 Elongation factor TS; Region: EF_TS; pfam00889 314225002004 Elongation factor TS; Region: EF_TS; pfam00889 314225002005 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 314225002006 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 314225002007 putative nucleotide binding site [chemical binding]; other site 314225002008 uridine monophosphate binding site [chemical binding]; other site 314225002009 homohexameric interface [polypeptide binding]; other site 314225002010 ribosome recycling factor; Reviewed; Region: frr; PRK00083 314225002011 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 314225002012 hinge region; other site 314225002013 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 314225002014 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 314225002015 catalytic residue [active] 314225002016 putative FPP diphosphate binding site; other site 314225002017 putative FPP binding hydrophobic cleft; other site 314225002018 dimer interface [polypeptide binding]; other site 314225002019 putative IPP diphosphate binding site; other site 314225002020 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 314225002021 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 314225002022 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 314225002023 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 314225002024 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 314225002025 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 314225002026 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 314225002027 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 314225002028 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 314225002029 protein binding site [polypeptide binding]; other site 314225002030 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 314225002031 putative substrate binding region [chemical binding]; other site 314225002032 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 314225002033 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 314225002034 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 314225002035 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 314225002036 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 314225002037 Surface antigen; Region: Bac_surface_Ag; pfam01103 314225002038 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 314225002039 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 314225002040 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 314225002041 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 314225002042 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 314225002043 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 314225002044 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 314225002045 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 314225002046 NAD binding site [chemical binding]; other site 314225002047 Phe binding site; other site 314225002048 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 314225002049 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 314225002050 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 314225002051 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 314225002052 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 314225002053 catalytic residues [active] 314225002054 central insert; other site 314225002055 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 314225002056 TPR repeat; Region: TPR_11; pfam13414 314225002057 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 314225002058 binding surface 314225002059 TPR motif; other site 314225002060 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 314225002061 potassium uptake protein; Region: kup; TIGR00794 314225002062 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 314225002063 GIY-YIG motif/motif A; other site 314225002064 putative active site [active] 314225002065 putative metal binding site [ion binding]; other site 314225002066 Intracellular septation protein A; Region: IspA; pfam04279 314225002067 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 314225002068 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 314225002069 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 314225002070 P loop; other site 314225002071 GTP binding site [chemical binding]; other site 314225002072 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 314225002073 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 314225002074 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 314225002075 FeS/SAM binding site; other site 314225002076 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 314225002077 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 314225002078 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 314225002079 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 314225002080 metal binding site [ion binding]; metal-binding site 314225002081 active site 314225002082 I-site; other site 314225002083 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 314225002084 EVE domain; Region: EVE; pfam01878 314225002085 thiamine pyrophosphate protein; Validated; Region: PRK08199 314225002086 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 314225002087 PYR/PP interface [polypeptide binding]; other site 314225002088 dimer interface [polypeptide binding]; other site 314225002089 TPP binding site [chemical binding]; other site 314225002090 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 314225002091 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 314225002092 TPP-binding site [chemical binding]; other site 314225002093 acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814 314225002094 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 314225002095 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 314225002096 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 314225002097 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 314225002098 dimerization interface [polypeptide binding]; other site 314225002099 ribonuclease D; Region: rnd; TIGR01388 314225002100 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 314225002101 catalytic site [active] 314225002102 putative active site [active] 314225002103 putative substrate binding site [chemical binding]; other site 314225002104 HRDC domain; Region: HRDC; pfam00570 314225002105 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 314225002106 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 314225002107 dimer interface [polypeptide binding]; other site 314225002108 anticodon binding site; other site 314225002109 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 314225002110 homodimer interface [polypeptide binding]; other site 314225002111 motif 1; other site 314225002112 active site 314225002113 motif 2; other site 314225002114 GAD domain; Region: GAD; pfam02938 314225002115 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 314225002116 active site 314225002117 motif 3; other site 314225002118 Domain of unknown function (DUF2383); Region: DUF2383; pfam09537 314225002119 acyl carrier protein; Provisional; Region: acpP; PRK00982 314225002120 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 314225002121 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 314225002122 dimer interface [polypeptide binding]; other site 314225002123 active site 314225002124 YceG-like family; Region: YceG; pfam02618 314225002125 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 314225002126 dimerization interface [polypeptide binding]; other site 314225002127 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 314225002128 integrase; Provisional; Region: PRK09692 314225002129 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 314225002130 active site 314225002131 Int/Topo IB signature motif; other site 314225002132 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 314225002133 N-acetyl-D-glucosamine binding site [chemical binding]; other site 314225002134 catalytic residue [active] 314225002135 CHC2 zinc finger; Region: zf-CHC2; cl17510 314225002136 DNA primase (bacterial type) [DNA replication, recombination, and repair]; Region: DnaG; COG0358 314225002137 Toprim domain; Region: Toprim_3; pfam13362 314225002138 Methyltransferase domain; Region: Methyltransf_26; pfam13659 314225002139 P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872 314225002140 Helicase_C-like; Region: Helicase_C_4; pfam13871 314225002141 Helicase_C-like; Region: Helicase_C_4; pfam13871 314225002142 ParB-like nuclease domain; Region: ParBc; pfam02195 314225002143 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 314225002144 Prokaryotic E2 family B; Region: Prok-E2_B; pfam14461 314225002145 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 314225002146 ATP binding site [chemical binding]; other site 314225002147 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 314225002148 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 314225002149 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 314225002150 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 314225002151 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 314225002152 dimer interface [polypeptide binding]; other site 314225002153 ssDNA binding site [nucleotide binding]; other site 314225002154 tetramer (dimer of dimers) interface [polypeptide binding]; other site 314225002155 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 314225002156 active site 314225002157 Int/Topo IB signature motif; other site 314225002158 DNA binding site [nucleotide binding] 314225002159 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 314225002160 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 314225002161 Phage integrase family; Region: Phage_integrase; pfam00589 314225002162 active site 314225002163 DNA binding site [nucleotide binding] 314225002164 Int/Topo IB signature motif; other site 314225002165 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 314225002166 HTH-like domain; Region: HTH_21; pfam13276 314225002167 Integrase core domain; Region: rve; pfam00665 314225002168 Integrase core domain; Region: rve_3; pfam13683 314225002169 Transposase; Region: HTH_Tnp_1; pfam01527 314225002170 Protein of unknown function (DUF983); Region: DUF983; pfam06170 314225002171 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 314225002172 DNA-binding site [nucleotide binding]; DNA binding site 314225002173 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 314225002174 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 314225002175 pyridoxal 5'-phosphate binding site [chemical binding]; other site 314225002176 homodimer interface [polypeptide binding]; other site 314225002177 catalytic residue [active] 314225002178 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 314225002179 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 314225002180 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 314225002181 active site 314225002182 DNA binding site [nucleotide binding] 314225002183 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 314225002184 DNA binding site [nucleotide binding] 314225002185 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 314225002186 nucleotide binding site [chemical binding]; other site 314225002187 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 314225002188 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 314225002189 putative DNA binding site [nucleotide binding]; other site 314225002190 putative homodimer interface [polypeptide binding]; other site 314225002191 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 314225002192 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 314225002193 protein binding site [polypeptide binding]; other site 314225002194 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 314225002195 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 314225002196 putative dimer interface [polypeptide binding]; other site 314225002197 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 314225002198 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 314225002199 putative dimer interface [polypeptide binding]; other site 314225002200 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 314225002201 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 314225002202 ring oligomerisation interface [polypeptide binding]; other site 314225002203 ATP/Mg binding site [chemical binding]; other site 314225002204 stacking interactions; other site 314225002205 hinge regions; other site 314225002206 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 314225002207 oligomerisation interface [polypeptide binding]; other site 314225002208 mobile loop; other site 314225002209 roof hairpin; other site 314225002210 Usg-like family; Region: Usg; pfam06233 314225002211 PAS domain; Region: PAS_9; pfam13426 314225002212 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 314225002213 putative active site [active] 314225002214 heme pocket [chemical binding]; other site 314225002215 hypothetical protein; Provisional; Region: PRK13559 314225002216 HWE histidine kinase; Region: HWE_HK; smart00911 314225002217 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 314225002218 GAF domain; Region: GAF; pfam01590 314225002219 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 314225002220 Histidine kinase; Region: HisKA_2; pfam07568 314225002221 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 314225002222 Mg2+ binding site [ion binding]; other site 314225002223 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 314225002224 active site 314225002225 catalytic residues [active] 314225002226 DNA binding site [nucleotide binding] 314225002227 Int/Topo IB signature motif; other site 314225002228 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 314225002229 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 314225002230 dimer interface [polypeptide binding]; other site 314225002231 ssDNA binding site [nucleotide binding]; other site 314225002232 tetramer (dimer of dimers) interface [polypeptide binding]; other site 314225002233 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 314225002234 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 314225002235 Walker A motif; other site 314225002236 ATP binding site [chemical binding]; other site 314225002237 Walker B motif; other site 314225002238 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 314225002239 TrwC relaxase; Region: TrwC; pfam08751 314225002240 AAA domain; Region: AAA_30; pfam13604 314225002241 Myosin N-terminal SH3-like domain; Region: Myosin_N; pfam02736 314225002242 HipA N-terminal domain; Region: Couple_hipA; pfam13657 314225002243 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 314225002244 HipA-like N-terminal domain; Region: HipA_N; pfam07805 314225002245 HipA-like C-terminal domain; Region: HipA_C; pfam07804 314225002246 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 314225002247 non-specific DNA binding site [nucleotide binding]; other site 314225002248 salt bridge; other site 314225002249 sequence-specific DNA binding site [nucleotide binding]; other site 314225002250 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 314225002251 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 314225002252 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 314225002253 active site 314225002254 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 314225002255 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 314225002256 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 314225002257 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 314225002258 putative substrate translocation pore; other site 314225002259 Major Facilitator Superfamily; Region: MFS_1; pfam07690 314225002260 Transcriptional regulators [Transcription]; Region: PurR; COG1609 314225002261 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 314225002262 DNA binding site [nucleotide binding] 314225002263 domain linker motif; other site 314225002264 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 314225002265 putative dimerization interface [polypeptide binding]; other site 314225002266 putative ligand binding site [chemical binding]; other site 314225002267 Restriction endonuclease; Region: Mrr_cat; pfam04471 314225002268 Predicted transcriptional regulator [Transcription]; Region: COG2932 314225002269 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 314225002270 Catalytic site [active] 314225002271 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 314225002272 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 314225002273 Catalytic site; other site 314225002274 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 314225002275 Conjugative relaxosome accessory transposon protein; Region: TraH; pfam06122 314225002276 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 314225002277 F plasmid transfer operon protein; Region: TraF; pfam13728 314225002278 conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355 314225002279 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673 314225002280 TraU protein; Region: TraU; pfam06834 314225002281 Sex factor F TraW protein N terminal; Region: TraW_N; cl10149 314225002282 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 314225002283 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 314225002284 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 314225002285 type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746 314225002286 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 314225002287 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 314225002288 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 314225002289 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 314225002290 dimerization domain [polypeptide binding]; other site 314225002291 dimer interface [polypeptide binding]; other site 314225002292 catalytic residues [active] 314225002293 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 314225002294 TraK protein; Region: TraK; pfam06586 314225002295 TraE protein; Region: TraE; pfam05309 314225002296 TraL protein; Region: TraL; pfam07178 314225002297 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 314225002298 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 314225002299 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 314225002300 DNA binding residues [nucleotide binding] 314225002301 dimer interface [polypeptide binding]; other site 314225002302 putative metal binding site [ion binding]; other site 314225002303 Protein of unknown function (DUF3703); Region: DUF3703; pfam12487 314225002304 Methyltransferase domain; Region: Methyltransf_31; pfam13847 314225002305 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 314225002306 S-adenosylmethionine binding site [chemical binding]; other site 314225002307 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 314225002308 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 314225002309 dimer interface [polypeptide binding]; other site 314225002310 decamer (pentamer of dimers) interface [polypeptide binding]; other site 314225002311 catalytic triad [active] 314225002312 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 314225002313 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 314225002314 N-terminal plug; other site 314225002315 ligand-binding site [chemical binding]; other site 314225002316 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 314225002317 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 314225002318 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 314225002319 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 314225002320 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 314225002321 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 314225002322 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 314225002323 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 314225002324 HlyD family secretion protein; Region: HlyD_3; pfam13437 314225002325 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 314225002326 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 314225002327 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 314225002328 Iron permease FTR1 family; Region: FTR1; cl00475 314225002329 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 314225002330 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 314225002331 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 314225002332 DNA binding residues [nucleotide binding] 314225002333 dimer interface [polypeptide binding]; other site 314225002334 putative metal binding site [ion binding]; other site 314225002335 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 314225002336 lipoprotein signal peptidase; Provisional; Region: PRK14787 314225002337 acetolactate synthase; Reviewed; Region: PRK08322 314225002338 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 314225002339 PYR/PP interface [polypeptide binding]; other site 314225002340 dimer interface [polypeptide binding]; other site 314225002341 TPP binding site [chemical binding]; other site 314225002342 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 314225002343 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 314225002344 TPP-binding site [chemical binding]; other site 314225002345 dimer interface [polypeptide binding]; other site 314225002346 Uncharacterized ALDH ( RL0313) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_RL0313; cd07148 314225002347 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 314225002348 NAD(P) binding site [chemical binding]; other site 314225002349 catalytic residues [active] 314225002350 FOG: CBS domain [General function prediction only]; Region: COG0517 314225002351 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 314225002352 Outer membrane efflux protein; Region: OEP; pfam02321 314225002353 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 314225002354 HlyD family secretion protein; Region: HlyD_3; pfam13437 314225002355 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 314225002356 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 314225002357 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 314225002358 multicopper oxidase; Provisional; Region: PRK10965 314225002359 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 314225002360 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 314225002361 Uncharacterized conserved protein [Function unknown]; Region: COG3350 314225002362 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 314225002363 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 314225002364 Soluble P-type ATPase [General function prediction only]; Region: COG4087 314225002365 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 314225002366 dimerization interface [polypeptide binding]; other site 314225002367 putative DNA binding site [nucleotide binding]; other site 314225002368 putative Zn2+ binding site [ion binding]; other site 314225002369 Putative phosphatase (DUF442); Region: DUF442; cl17385 314225002370 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 314225002371 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 314225002372 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 314225002373 active site residue [active] 314225002374 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 314225002375 active site residue [active] 314225002376 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 314225002377 NADH(P)-binding; Region: NAD_binding_10; pfam13460 314225002378 NAD(P) binding site [chemical binding]; other site 314225002379 active site 314225002380 Domain of unknown function (DUF305); Region: DUF305; cl17794 314225002381 Ion channel; Region: Ion_trans_2; pfam07885 314225002382 Glutaredoxin and related proteins [Posttranslational modification, protein turnover, chaperones]; Region: GrxC; COG0695 314225002383 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 314225002384 Protein of unknown function, DUF; Region: DUF411; cl01142 314225002385 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 314225002386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 314225002387 S-adenosylmethionine binding site [chemical binding]; other site 314225002388 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 314225002389 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 314225002390 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 314225002391 DNA binding residues [nucleotide binding] 314225002392 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 314225002393 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 314225002394 Multicopper oxidase; Region: Cu-oxidase; pfam00394 314225002395 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 314225002396 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 314225002397 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 314225002398 SnoaL-like domain; Region: SnoaL_3; pfam13474 314225002399 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 314225002400 putative solute:sodium symporter small subunit; Region: Na_symport_sm; TIGR03647 314225002401 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 314225002402 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 314225002403 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 314225002404 Na binding site [ion binding]; other site 314225002405 acetyl-CoA synthetase; Provisional; Region: PRK00174 314225002406 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 314225002407 active site 314225002408 CoA binding site [chemical binding]; other site 314225002409 acyl-activating enzyme (AAE) consensus motif; other site 314225002410 AMP binding site [chemical binding]; other site 314225002411 acetate binding site [chemical binding]; other site 314225002412 enoyl-CoA hydratase; Provisional; Region: PRK09245 314225002413 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 314225002414 substrate binding site [chemical binding]; other site 314225002415 oxyanion hole (OAH) forming residues; other site 314225002416 trimer interface [polypeptide binding]; other site 314225002417 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 314225002418 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 314225002419 active site 314225002420 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 314225002421 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 314225002422 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 314225002423 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 314225002424 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 314225002425 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 314225002426 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 314225002427 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 314225002428 active site 314225002429 homotetramer interface [polypeptide binding]; other site 314225002430 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 314225002431 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 314225002432 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 314225002433 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 314225002434 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 314225002435 MAPEG family; Region: MAPEG; pfam01124 314225002436 MAPEG family; Region: MAPEG; pfam01124 314225002437 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 314225002438 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 314225002439 tetramer interface [polypeptide binding]; other site 314225002440 pyridoxal 5'-phosphate binding site [chemical binding]; other site 314225002441 catalytic residue [active] 314225002442 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 314225002443 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 314225002444 GxxExxY protein; Region: GxxExxY; TIGR04256 314225002445 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 314225002446 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 314225002447 dimer interface [polypeptide binding]; other site 314225002448 active site 314225002449 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 314225002450 catalytic residues [active] 314225002451 substrate binding site [chemical binding]; other site 314225002452 Protein of unknown function (DUF3137); Region: DUF3137; pfam11335 314225002453 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 314225002454 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 314225002455 dimer interface [polypeptide binding]; other site 314225002456 active site 314225002457 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 314225002458 catalytic residues [active] 314225002459 substrate binding site [chemical binding]; other site 314225002460 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 314225002461 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 314225002462 PAS domain; Region: PAS_9; pfam13426 314225002463 putative active site [active] 314225002464 heme pocket [chemical binding]; other site 314225002465 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 314225002466 DNA binding residues [nucleotide binding] 314225002467 dimerization interface [polypeptide binding]; other site 314225002468 PAS domain; Region: PAS_9; pfam13426 314225002469 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 314225002470 putative active site [active] 314225002471 heme pocket [chemical binding]; other site 314225002472 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 314225002473 metal binding site [ion binding]; metal-binding site 314225002474 active site 314225002475 I-site; other site 314225002476 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 314225002477 PilZ domain; Region: PilZ; pfam07238 314225002478 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 314225002479 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 314225002480 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 314225002481 putative FMN binding site [chemical binding]; other site 314225002482 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 314225002483 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 314225002484 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 314225002485 substrate-cofactor binding pocket; other site 314225002486 pyridoxal 5'-phosphate binding site [chemical binding]; other site 314225002487 catalytic residue [active] 314225002488 glutamate racemase; Provisional; Region: PRK00865 314225002489 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 314225002490 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 314225002491 DNA protecting protein DprA; Region: dprA; TIGR00732 314225002492 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 314225002493 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 314225002494 active site 314225002495 interdomain interaction site; other site 314225002496 putative metal-binding site [ion binding]; other site 314225002497 nucleotide binding site [chemical binding]; other site 314225002498 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 314225002499 domain I; other site 314225002500 DNA binding groove [nucleotide binding] 314225002501 phosphate binding site [ion binding]; other site 314225002502 domain II; other site 314225002503 domain III; other site 314225002504 nucleotide binding site [chemical binding]; other site 314225002505 catalytic site [active] 314225002506 domain IV; other site 314225002507 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 314225002508 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 314225002509 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 314225002510 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 314225002511 Response regulator receiver domain; Region: Response_reg; pfam00072 314225002512 active site 314225002513 phosphorylation site [posttranslational modification] 314225002514 intermolecular recognition site; other site 314225002515 dimerization interface [polypeptide binding]; other site 314225002516 GTPase Era; Reviewed; Region: era; PRK00089 314225002517 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 314225002518 G1 box; other site 314225002519 GTP/Mg2+ binding site [chemical binding]; other site 314225002520 Switch I region; other site 314225002521 G2 box; other site 314225002522 Switch II region; other site 314225002523 G3 box; other site 314225002524 G4 box; other site 314225002525 G5 box; other site 314225002526 KH domain; Region: KH_2; pfam07650 314225002527 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 314225002528 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 314225002529 dimerization interface [polypeptide binding]; other site 314225002530 active site 314225002531 metal binding site [ion binding]; metal-binding site 314225002532 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 314225002533 dsRNA binding site [nucleotide binding]; other site 314225002534 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 314225002535 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 314225002536 Catalytic site [active] 314225002537 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 314225002538 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 314225002539 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 314225002540 active site 314225002541 dimer interface [polypeptide binding]; other site 314225002542 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 314225002543 dimer interface [polypeptide binding]; other site 314225002544 active site 314225002545 PAS domain; Region: PAS_9; pfam13426 314225002546 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 314225002547 putative active site [active] 314225002548 heme pocket [chemical binding]; other site 314225002549 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 314225002550 Histidine kinase; Region: HisKA_2; pfam07568 314225002551 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 314225002552 ATP binding site [chemical binding]; other site 314225002553 Mg2+ binding site [ion binding]; other site 314225002554 G-X-G motif; other site 314225002555 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 314225002556 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 314225002557 ATP binding site [chemical binding]; other site 314225002558 Mg++ binding site [ion binding]; other site 314225002559 motif III; other site 314225002560 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 314225002561 nucleotide binding region [chemical binding]; other site 314225002562 ATP-binding site [chemical binding]; other site 314225002563 glutathione reductase; Validated; Region: PRK06116 314225002564 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 314225002565 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 314225002566 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 314225002567 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 314225002568 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 314225002569 NADP binding site [chemical binding]; other site 314225002570 putative substrate binding site [chemical binding]; other site 314225002571 active site 314225002572 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 314225002573 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 314225002574 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 314225002575 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 314225002576 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 314225002577 dimer interface [polypeptide binding]; other site 314225002578 substrate binding site [chemical binding]; other site 314225002579 metal binding site [ion binding]; metal-binding site 314225002580 enoyl-CoA hydratase; Provisional; Region: PRK05981 314225002581 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 314225002582 substrate binding site [chemical binding]; other site 314225002583 oxyanion hole (OAH) forming residues; other site 314225002584 trimer interface [polypeptide binding]; other site 314225002585 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 314225002586 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 314225002587 putative C-terminal domain interface [polypeptide binding]; other site 314225002588 putative GSH binding site (G-site) [chemical binding]; other site 314225002589 putative dimer interface [polypeptide binding]; other site 314225002590 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 314225002591 N-terminal domain interface [polypeptide binding]; other site 314225002592 dimer interface [polypeptide binding]; other site 314225002593 substrate binding pocket (H-site) [chemical binding]; other site 314225002594 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 314225002595 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 314225002596 active site 314225002597 substrate binding site [chemical binding]; other site 314225002598 coenzyme B12 binding site [chemical binding]; other site 314225002599 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 314225002600 B12 binding site [chemical binding]; other site 314225002601 cobalt ligand [ion binding]; other site 314225002602 biotin synthase; Region: bioB; TIGR00433 314225002603 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 314225002604 FeS/SAM binding site; other site 314225002605 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 314225002606 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 314225002607 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 314225002608 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 314225002609 ATP-grasp domain; Region: ATP-grasp_4; cl17255 314225002610 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 314225002611 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 314225002612 carboxyltransferase (CT) interaction site; other site 314225002613 biotinylation site [posttranslational modification]; other site 314225002614 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 314225002615 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 314225002616 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 314225002617 dimer interface [polypeptide binding]; other site 314225002618 putative tRNA-binding site [nucleotide binding]; other site 314225002619 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 314225002620 Coenzyme A binding pocket [chemical binding]; other site 314225002621 Putative cyclase; Region: Cyclase; pfam04199 314225002622 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 314225002623 active site 314225002624 dimer interface [polypeptide binding]; other site 314225002625 metal binding site [ion binding]; metal-binding site 314225002626 shikimate kinase; Provisional; Region: PRK13946 314225002627 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 314225002628 ADP binding site [chemical binding]; other site 314225002629 magnesium binding site [ion binding]; other site 314225002630 putative shikimate binding site; other site 314225002631 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 314225002632 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 314225002633 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 314225002634 active site 314225002635 DNA binding site [nucleotide binding] 314225002636 Int/Topo IB signature motif; other site 314225002637 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 314225002638 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 314225002639 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 314225002640 Peptidase family M48; Region: Peptidase_M48; pfam01435 314225002641 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 314225002642 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 314225002643 Flp/Fap pilin component; Region: Flp_Fap; cl01585 314225002644 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 314225002645 active site 314225002646 8-oxo-dGMP binding site [chemical binding]; other site 314225002647 nudix motif; other site 314225002648 metal binding site [ion binding]; metal-binding site 314225002649 Hemerythrin family; Region: Hemerythrin-like; cl15774 314225002650 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 314225002651 GTP cyclohydrolase I; Provisional; Region: PLN03044 314225002652 active site 314225002653 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 314225002654 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 314225002655 WHG domain; Region: WHG; pfam13305 314225002656 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 314225002657 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 314225002658 N-terminal plug; other site 314225002659 ligand-binding site [chemical binding]; other site 314225002660 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 314225002661 catalytic triad [active] 314225002662 dimer interface [polypeptide binding]; other site 314225002663 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 314225002664 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 314225002665 homotetramer interface [polypeptide binding]; other site 314225002666 ligand binding site [chemical binding]; other site 314225002667 catalytic site [active] 314225002668 NAD binding site [chemical binding]; other site 314225002669 PAS fold; Region: PAS_7; pfam12860 314225002670 PAS fold; Region: PAS_7; pfam12860 314225002671 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 314225002672 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 314225002673 dimer interface [polypeptide binding]; other site 314225002674 phosphorylation site [posttranslational modification] 314225002675 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 314225002676 ATP binding site [chemical binding]; other site 314225002677 Mg2+ binding site [ion binding]; other site 314225002678 G-X-G motif; other site 314225002679 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 314225002680 Phosphotransferase enzyme family; Region: APH; pfam01636 314225002681 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 314225002682 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 314225002683 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 314225002684 Substrate binding site; other site 314225002685 metal-binding site 314225002686 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 314225002687 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 314225002688 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 314225002689 Family description; Region: UvrD_C_2; pfam13538 314225002690 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 314225002691 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 314225002692 catalytic residues [active] 314225002693 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 314225002694 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 314225002695 active site 314225002696 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 314225002697 heterotetramer interface [polypeptide binding]; other site 314225002698 active site pocket [active] 314225002699 cleavage site 314225002700 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 314225002701 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 314225002702 SEC-C motif; Region: SEC-C; pfam02810 314225002703 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 314225002704 ATP-NAD kinase; Region: NAD_kinase; pfam01513 314225002705 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 314225002706 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 314225002707 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 314225002708 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 314225002709 ATP binding site [chemical binding]; other site 314225002710 putative Mg++ binding site [ion binding]; other site 314225002711 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 314225002712 nucleotide binding region [chemical binding]; other site 314225002713 ATP-binding site [chemical binding]; other site 314225002714 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 314225002715 Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937 314225002716 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 314225002717 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 314225002718 generic binding surface II; other site 314225002719 ssDNA binding site; other site 314225002720 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 314225002721 ATP binding site [chemical binding]; other site 314225002722 putative Mg++ binding site [ion binding]; other site 314225002723 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 314225002724 nucleotide binding region [chemical binding]; other site 314225002725 ATP-binding site [chemical binding]; other site 314225002726 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 314225002727 Low molecular weight phosphatase family; Region: LMWPc; cd00115 314225002728 active site 314225002729 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 314225002730 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 314225002731 ABC1 family; Region: ABC1; pfam03109 314225002732 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; cl17526 314225002733 Protein of unknown function (DUF3429); Region: DUF3429; pfam11911 314225002734 thymidylate synthase; Reviewed; Region: thyA; PRK01827 314225002735 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 314225002736 dimerization interface [polypeptide binding]; other site 314225002737 active site 314225002738 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 314225002739 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 314225002740 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 314225002741 tetramer interface [polypeptide binding]; other site 314225002742 TPP-binding site [chemical binding]; other site 314225002743 heterodimer interface [polypeptide binding]; other site 314225002744 phosphorylation loop region [posttranslational modification] 314225002745 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 314225002746 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 314225002747 alpha subunit interface [polypeptide binding]; other site 314225002748 TPP binding site [chemical binding]; other site 314225002749 heterodimer interface [polypeptide binding]; other site 314225002750 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 314225002751 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 314225002752 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 314225002753 E3 interaction surface; other site 314225002754 lipoyl attachment site [posttranslational modification]; other site 314225002755 e3 binding domain; Region: E3_binding; pfam02817 314225002756 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 314225002757 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 314225002758 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 314225002759 FMN binding site [chemical binding]; other site 314225002760 substrate binding site [chemical binding]; other site 314225002761 putative catalytic residue [active] 314225002762 MFS/sugar transport protein; Region: MFS_2; pfam13347 314225002763 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 314225002764 Protein of unknown function (DUF2842); Region: DUF2842; pfam11003 314225002765 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 314225002766 Cell division protein ZapA; Region: ZapA; pfam05164 314225002767 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 314225002768 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 314225002769 TPP-binding site [chemical binding]; other site 314225002770 dimer interface [polypeptide binding]; other site 314225002771 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 314225002772 PYR/PP interface [polypeptide binding]; other site 314225002773 dimer interface [polypeptide binding]; other site 314225002774 TPP binding site [chemical binding]; other site 314225002775 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 314225002776 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 314225002777 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 314225002778 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 314225002779 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 314225002780 Phosphoglycerate kinase; Region: PGK; pfam00162 314225002781 substrate binding site [chemical binding]; other site 314225002782 hinge regions; other site 314225002783 ADP binding site [chemical binding]; other site 314225002784 catalytic site [active] 314225002785 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 314225002786 CoenzymeA binding site [chemical binding]; other site 314225002787 subunit interaction site [polypeptide binding]; other site 314225002788 PHB binding site; other site 314225002789 Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; pfam13759 314225002790 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 314225002791 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 314225002792 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 314225002793 catalytic residue [active] 314225002794 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 314225002795 thiamine phosphate binding site [chemical binding]; other site 314225002796 active site 314225002797 pyrophosphate binding site [ion binding]; other site 314225002798 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 314225002799 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 314225002800 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 314225002801 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 314225002802 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 314225002803 Peptidase family M23; Region: Peptidase_M23; pfam01551 314225002804 elongation factor P; Validated; Region: PRK00529 314225002805 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 314225002806 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 314225002807 RNA binding site [nucleotide binding]; other site 314225002808 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 314225002809 RNA binding site [nucleotide binding]; other site 314225002810 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 314225002811 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 314225002812 active site 314225002813 dimerization interface [polypeptide binding]; other site 314225002814 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 314225002815 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 314225002816 transmembrane helices; other site 314225002817 TrkA-C domain; Region: TrkA_C; pfam02080 314225002818 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 314225002819 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 314225002820 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 314225002821 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 314225002822 metal binding site [ion binding]; metal-binding site 314225002823 putative dimer interface [polypeptide binding]; other site 314225002824 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 314225002825 tetramer interface [polypeptide binding]; other site 314225002826 active site 314225002827 Mg2+/Mn2+ binding site [ion binding]; other site 314225002828 isocitrate lyase; Region: PLN02892 314225002829 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 314225002830 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 314225002831 non-specific DNA binding site [nucleotide binding]; other site 314225002832 salt bridge; other site 314225002833 sequence-specific DNA binding site [nucleotide binding]; other site 314225002834 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 314225002835 Domain of unknown function (DUF955); Region: DUF955; pfam06114 314225002836 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 314225002837 sugar transferase, PEP-CTERM system associated; Region: EpsB_2; TIGR03013 314225002838 Bacterial sugar transferase; Region: Bac_transf; pfam02397 314225002839 putative PEP-CTERM system histidine kinase; Region: PEP_his_kin; TIGR02916 314225002840 GAF domain; Region: GAF_3; pfam13492 314225002841 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 314225002842 ATP binding site [chemical binding]; other site 314225002843 Mg2+ binding site [ion binding]; other site 314225002844 G-X-G motif; other site 314225002845 PEP-CTERM-box response regulator transcription factor; Region: PEP_resp_reg; TIGR02915 314225002846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 314225002847 active site 314225002848 phosphorylation site [posttranslational modification] 314225002849 intermolecular recognition site; other site 314225002850 dimerization interface [polypeptide binding]; other site 314225002851 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 314225002852 Walker A motif; other site 314225002853 ATP binding site [chemical binding]; other site 314225002854 Walker B motif; other site 314225002855 arginine finger; other site 314225002856 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 314225002857 TPR repeat; Region: TPR_11; pfam13414 314225002858 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 314225002859 TPR motif; other site 314225002860 binding surface 314225002861 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 314225002862 binding surface 314225002863 TPR motif; other site 314225002864 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 314225002865 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 314225002866 hypothetical protein; Provisional; Region: PRK14013 314225002867 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 314225002868 oligomerization interface [polypeptide binding]; other site 314225002869 active site 314225002870 metal binding site [ion binding]; metal-binding site 314225002871 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 314225002872 Na2 binding site [ion binding]; other site 314225002873 putative substrate binding site 1 [chemical binding]; other site 314225002874 Na binding site 1 [ion binding]; other site 314225002875 putative substrate binding site 2 [chemical binding]; other site 314225002876 amino acid transporter; Region: 2A0306; TIGR00909 314225002877 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 314225002878 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 314225002879 Uncharacterized conserved protein [Function unknown]; Region: COG4544 314225002880 DNA Polymerase Y-family; Region: PolY_like; cd03468 314225002881 active site 314225002882 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 314225002883 DNA binding site [nucleotide binding] 314225002884 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4337 314225002885 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 314225002886 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 314225002887 FeS/SAM binding site; other site 314225002888 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 314225002889 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 314225002890 Fe-S cluster binding site [ion binding]; other site 314225002891 active site 314225002892 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 314225002893 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 314225002894 putative active site [active] 314225002895 putative PHP Thumb interface [polypeptide binding]; other site 314225002896 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 314225002897 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 314225002898 generic binding surface I; other site 314225002899 generic binding surface II; other site 314225002900 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 314225002901 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 314225002902 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 314225002903 active site 314225002904 phosphorylation site [posttranslational modification] 314225002905 intermolecular recognition site; other site 314225002906 dimerization interface [polypeptide binding]; other site 314225002907 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 314225002908 DNA binding site [nucleotide binding] 314225002909 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 314225002910 PhoU domain; Region: PhoU; pfam01895 314225002911 PhoU domain; Region: PhoU; pfam01895 314225002912 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 314225002913 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 314225002914 Walker A/P-loop; other site 314225002915 ATP binding site [chemical binding]; other site 314225002916 Q-loop/lid; other site 314225002917 ABC transporter signature motif; other site 314225002918 Walker B; other site 314225002919 D-loop; other site 314225002920 H-loop/switch region; other site 314225002921 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 314225002922 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 314225002923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 314225002924 dimer interface [polypeptide binding]; other site 314225002925 conserved gate region; other site 314225002926 putative PBP binding loops; other site 314225002927 ABC-ATPase subunit interface; other site 314225002928 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 314225002929 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 314225002930 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 314225002931 dimer interface [polypeptide binding]; other site 314225002932 conserved gate region; other site 314225002933 putative PBP binding loops; other site 314225002934 ABC-ATPase subunit interface; other site 314225002935 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 314225002936 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 314225002937 dimer interface [polypeptide binding]; other site 314225002938 phosphorylation site [posttranslational modification] 314225002939 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 314225002940 ATP binding site [chemical binding]; other site 314225002941 Mg2+ binding site [ion binding]; other site 314225002942 G-X-G motif; other site 314225002943 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 314225002944 DHH family; Region: DHH; pfam01368 314225002945 DHHA1 domain; Region: DHHA1; pfam02272 314225002946 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 314225002947 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 314225002948 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 314225002949 FMN binding site [chemical binding]; other site 314225002950 substrate binding site [chemical binding]; other site 314225002951 putative catalytic residue [active] 314225002952 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 314225002953 Amidohydrolase; Region: Amidohydro_2; pfam04909 314225002954 aldolase II superfamily protein; Provisional; Region: PRK07044 314225002955 intersubunit interface [polypeptide binding]; other site 314225002956 active site 314225002957 Zn2+ binding site [ion binding]; other site 314225002958 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 314225002959 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 314225002960 active site 314225002961 2-isopropylmalate synthase; Validated; Region: PRK03739 314225002962 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 314225002963 active site 314225002964 catalytic residues [active] 314225002965 metal binding site [ion binding]; metal-binding site 314225002966 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 314225002967 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 314225002968 CoenzymeA binding site [chemical binding]; other site 314225002969 subunit interaction site [polypeptide binding]; other site 314225002970 PHB binding site; other site 314225002971 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 314225002972 Epoxide hydrolase N terminus; Region: EHN; pfam06441 314225002973 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 314225002974 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 314225002975 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 314225002976 phosphate binding site [ion binding]; other site 314225002977 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 314225002978 Uncharacterized conserved protein [Function unknown]; Region: COG2353 314225002979 ketol-acid reductoisomerase; Provisional; Region: PRK05479 314225002980 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 314225002981 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 314225002982 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 314225002983 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 314225002984 putative valine binding site [chemical binding]; other site 314225002985 dimer interface [polypeptide binding]; other site 314225002986 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 314225002987 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 314225002988 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 314225002989 PYR/PP interface [polypeptide binding]; other site 314225002990 dimer interface [polypeptide binding]; other site 314225002991 TPP binding site [chemical binding]; other site 314225002992 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 314225002993 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 314225002994 TPP-binding site [chemical binding]; other site 314225002995 dimer interface [polypeptide binding]; other site 314225002996 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 314225002997 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 314225002998 phosphoserine phosphatase SerB; Region: serB; TIGR00338 314225002999 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 314225003000 motif II; other site 314225003001 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 314225003002 Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney, using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers; Region: iodotyrosine_dehalogenase; cd02144 314225003003 putative FMN binding site [chemical binding]; other site 314225003004 putative dimer interface [polypeptide binding]; other site 314225003005 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 314225003006 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 314225003007 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 314225003008 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 314225003009 dimerization interface [polypeptide binding]; other site 314225003010 ATP binding site [chemical binding]; other site 314225003011 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 314225003012 dimerization interface [polypeptide binding]; other site 314225003013 ATP binding site [chemical binding]; other site 314225003014 Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945 314225003015 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 314225003016 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 314225003017 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 314225003018 substrate binding pocket [chemical binding]; other site 314225003019 chain length determination region; other site 314225003020 substrate-Mg2+ binding site; other site 314225003021 catalytic residues [active] 314225003022 aspartate-rich region 1; other site 314225003023 active site lid residues [active] 314225003024 aspartate-rich region 2; other site 314225003025 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 314225003026 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 314225003027 active site 314225003028 (T/H)XGH motif; other site 314225003029 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 314225003030 active site 314225003031 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 314225003032 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 314225003033 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 314225003034 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 314225003035 Walker A/P-loop; other site 314225003036 ATP binding site [chemical binding]; other site 314225003037 Q-loop/lid; other site 314225003038 ABC transporter signature motif; other site 314225003039 Walker B; other site 314225003040 D-loop; other site 314225003041 H-loop/switch region; other site 314225003042 ABC-2 type transporter; Region: ABC2_membrane; cl17235 314225003043 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 314225003044 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 314225003045 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 314225003046 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 314225003047 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 314225003048 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 314225003049 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 314225003050 RNA binding surface [nucleotide binding]; other site 314225003051 Chorismate mutase type II; Region: CM_2; cl00693 314225003052 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 314225003053 GIY-YIG motif/motif A; other site 314225003054 putative active site [active] 314225003055 putative metal binding site [ion binding]; other site 314225003056 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 314225003057 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 314225003058 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 314225003059 ATP cone domain; Region: ATP-cone; pfam03477 314225003060 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 314225003061 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 314225003062 dimer interface [polypeptide binding]; other site 314225003063 active site 314225003064 glycine-pyridoxal phosphate binding site [chemical binding]; other site 314225003065 folate binding site [chemical binding]; other site 314225003066 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 314225003067 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 314225003068 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 314225003069 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 314225003070 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 314225003071 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 314225003072 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 314225003073 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 314225003074 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 314225003075 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 314225003076 DNA binding residues [nucleotide binding] 314225003077 DNA primase, catalytic core; Region: dnaG; TIGR01391 314225003078 CHC2 zinc finger; Region: zf-CHC2; pfam01807 314225003079 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 314225003080 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 314225003081 active site 314225003082 metal binding site [ion binding]; metal-binding site 314225003083 interdomain interaction site; other site 314225003084 Yqey-like protein; Region: YqeY; pfam09424 314225003085 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 314225003086 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 314225003087 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 314225003088 catalytic site [active] 314225003089 subunit interface [polypeptide binding]; other site 314225003090 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 314225003091 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 314225003092 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 314225003093 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 314225003094 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 314225003095 ATP-grasp domain; Region: ATP-grasp_4; cl17255 314225003096 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 314225003097 IMP binding site; other site 314225003098 dimer interface [polypeptide binding]; other site 314225003099 partial ornithine binding site; other site 314225003100 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 314225003101 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 314225003102 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 314225003103 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 314225003104 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 314225003105 Coenzyme A binding pocket [chemical binding]; other site 314225003106 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 314225003107 enolase; Provisional; Region: eno; PRK00077 314225003108 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 314225003109 dimer interface [polypeptide binding]; other site 314225003110 metal binding site [ion binding]; metal-binding site 314225003111 substrate binding pocket [chemical binding]; other site 314225003112 MarR family; Region: MarR_2; cl17246 314225003113 Phosphotransferase enzyme family; Region: APH; pfam01636 314225003114 Ecdysteroid kinase; Region: EcKinase; cl17738 314225003115 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 314225003116 homopentamer interface [polypeptide binding]; other site 314225003117 active site 314225003118 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 314225003119 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 314225003120 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 314225003121 dimerization interface [polypeptide binding]; other site 314225003122 active site 314225003123 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 314225003124 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 314225003125 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 314225003126 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 314225003127 rod shape-determining protein MreC; Provisional; Region: PRK13922 314225003128 rod shape-determining protein MreC; Region: MreC; pfam04085 314225003129 rod shape-determining protein MreB; Provisional; Region: PRK13927 314225003130 MreB and similar proteins; Region: MreB_like; cd10225 314225003131 nucleotide binding site [chemical binding]; other site 314225003132 Mg binding site [ion binding]; other site 314225003133 putative protofilament interaction site [polypeptide binding]; other site 314225003134 RodZ interaction site [polypeptide binding]; other site 314225003135 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 314225003136 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 314225003137 ATP binding site [chemical binding]; other site 314225003138 Mg2+ binding site [ion binding]; other site 314225003139 G-X-G motif; other site 314225003140 DNA mismatch repair protein, C-terminal domain; Region: DNA_mis_repair; pfam01119 314225003141 ATP binding site [chemical binding]; other site 314225003142 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 314225003143 Glutaredoxin and related proteins [Posttranslational modification, protein turnover, chaperones]; Region: GrxC; COG0695 314225003144 Methylamine utilisation protein MauE; Region: MauE; pfam07291 314225003145 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 314225003146 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 314225003147 GTP-binding protein YchF; Reviewed; Region: PRK09601 314225003148 YchF GTPase; Region: YchF; cd01900 314225003149 G1 box; other site 314225003150 GTP/Mg2+ binding site [chemical binding]; other site 314225003151 Switch I region; other site 314225003152 G2 box; other site 314225003153 Switch II region; other site 314225003154 G3 box; other site 314225003155 G4 box; other site 314225003156 G5 box; other site 314225003157 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 314225003158 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 314225003159 NADP binding site [chemical binding]; other site 314225003160 active site 314225003161 steroid binding site; other site 314225003162 AAA domain; Region: AAA_17; pfam13207 314225003163 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 314225003164 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 314225003165 putative active site [active] 314225003166 catalytic residue [active] 314225003167 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 314225003168 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 314225003169 5S rRNA interface [nucleotide binding]; other site 314225003170 CTC domain interface [polypeptide binding]; other site 314225003171 L16 interface [polypeptide binding]; other site 314225003172 TraB family; Region: TraB; pfam01963 314225003173 TraB family; Region: TraB; pfam01963 314225003174 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 314225003175 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 314225003176 putative [Fe4-S4] binding site [ion binding]; other site 314225003177 putative molybdopterin cofactor binding site [chemical binding]; other site 314225003178 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 314225003179 putative molybdopterin cofactor binding site; other site 314225003180 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 314225003181 dimer interface [polypeptide binding]; other site 314225003182 motif 1; other site 314225003183 active site 314225003184 motif 2; other site 314225003185 motif 3; other site 314225003186 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 314225003187 pyruvate phosphate dikinase; Provisional; Region: PRK09279 314225003188 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 314225003189 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 314225003190 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 314225003191 Methyltransferase domain; Region: Methyltransf_23; pfam13489 314225003192 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 314225003193 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 314225003194 active site 314225003195 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 314225003196 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 314225003197 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 314225003198 DNA binding residues [nucleotide binding] 314225003199 putative dimer interface [polypeptide binding]; other site 314225003200 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 314225003201 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 314225003202 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 314225003203 FAD binding site [chemical binding]; other site 314225003204 substrate binding site [chemical binding]; other site 314225003205 catalytic residues [active] 314225003206 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 314225003207 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 314225003208 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 314225003209 dimer interface [polypeptide binding]; other site 314225003210 pyridoxal 5'-phosphate binding site [chemical binding]; other site 314225003211 catalytic residue [active] 314225003212 H+ Antiporter protein; Region: 2A0121; TIGR00900 314225003213 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 314225003214 putative substrate translocation pore; other site 314225003215 PilZ domain; Region: PilZ; pfam07238 314225003216 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 314225003217 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 314225003218 active site 314225003219 HIGH motif; other site 314225003220 dimer interface [polypeptide binding]; other site 314225003221 KMSKS motif; other site 314225003222 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 314225003223 putative ligand binding site [chemical binding]; other site 314225003224 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 314225003225 Protein of unknown function (DUF817); Region: DUF817; pfam05675 314225003226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 314225003227 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 314225003228 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 314225003229 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 314225003230 dimer interface [polypeptide binding]; other site 314225003231 putative CheW interface [polypeptide binding]; other site 314225003232 hypothetical protein; Provisional; Region: PRK06132 314225003233 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 314225003234 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 314225003235 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 314225003236 Walker A motif; other site 314225003237 ATP binding site [chemical binding]; other site 314225003238 Walker B motif; other site 314225003239 arginine finger; other site 314225003240 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 314225003241 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 314225003242 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 314225003243 OsmC-like protein; Region: OsmC; pfam02566 314225003244 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 314225003245 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 314225003246 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 314225003247 Mg2+ binding site [ion binding]; other site 314225003248 G-X-G motif; other site 314225003249 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 314225003250 anchoring element; other site 314225003251 dimer interface [polypeptide binding]; other site 314225003252 ATP binding site [chemical binding]; other site 314225003253 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 314225003254 active site 314225003255 putative metal-binding site [ion binding]; other site 314225003256 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 314225003257 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 314225003258 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 314225003259 putative ligand binding site [chemical binding]; other site 314225003260 Predicted methyltransferases [General function prediction only]; Region: COG0313 314225003261 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 314225003262 putative SAM binding site [chemical binding]; other site 314225003263 putative homodimer interface [polypeptide binding]; other site 314225003264 hypothetical protein; Reviewed; Region: PRK12497 314225003265 glutathione synthetase; Provisional; Region: PRK05246 314225003266 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 314225003267 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 314225003268 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 314225003269 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 314225003270 active site 314225003271 DNA binding site [nucleotide binding] 314225003272 Int/Topo IB signature motif; other site 314225003273 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 314225003274 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 314225003275 FeS/SAM binding site; other site 314225003276 HemN C-terminal domain; Region: HemN_C; pfam06969 314225003277 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 314225003278 active site 314225003279 dimerization interface [polypeptide binding]; other site 314225003280 ribonuclease PH; Reviewed; Region: rph; PRK00173 314225003281 Ribonuclease PH; Region: RNase_PH_bact; cd11362 314225003282 hexamer interface [polypeptide binding]; other site 314225003283 active site 314225003284 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 314225003285 GrpE; Region: GrpE; pfam01025 314225003286 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 314225003287 dimer interface [polypeptide binding]; other site 314225003288 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 314225003289 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 314225003290 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 314225003291 substrate binding site [chemical binding]; other site 314225003292 oxyanion hole (OAH) forming residues; other site 314225003293 trimer interface [polypeptide binding]; other site 314225003294 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 314225003295 alanyl-tRNA synthetase; Region: PLN02900 314225003296 Indoleamine 2,3-dioxygenase; Region: IDO; pfam01231 314225003297 Protein of unknown function (DUF461); Region: DUF461; pfam04314 314225003298 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 314225003299 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 314225003300 nucleotide binding site [chemical binding]; other site 314225003301 NEF interaction site [polypeptide binding]; other site 314225003302 SBD interface [polypeptide binding]; other site 314225003303 chaperone protein DnaJ; Provisional; Region: PRK10767 314225003304 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 314225003305 HSP70 interaction site [polypeptide binding]; other site 314225003306 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 314225003307 Zn binding sites [ion binding]; other site 314225003308 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 314225003309 dimer interface [polypeptide binding]; other site 314225003310 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 314225003311 patatin-related protein; Region: TIGR03607 314225003312 DNA repair protein RadA; Provisional; Region: PRK11823 314225003313 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 314225003314 Walker A motif/ATP binding site; other site 314225003315 ATP binding site [chemical binding]; other site 314225003316 Walker B motif; other site 314225003317 Colicin V production protein; Region: Colicin_V; pfam02674 314225003318 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 314225003319 trimerization site [polypeptide binding]; other site 314225003320 active site 314225003321 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 314225003322 putative substrate translocation pore; other site 314225003323 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 314225003324 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 314225003325 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 314225003326 catalytic residue [active] 314225003327 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 314225003328 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 314225003329 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 314225003330 prolyl-tRNA synthetase; Provisional; Region: PRK08661 314225003331 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 314225003332 dimer interface [polypeptide binding]; other site 314225003333 motif 1; other site 314225003334 active site 314225003335 motif 2; other site 314225003336 motif 3; other site 314225003337 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 314225003338 anticodon binding site; other site 314225003339 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase (AAP)-like; Region: M28_AAP_like; cd05642 314225003340 Peptidase family M28; Region: Peptidase_M28; pfam04389 314225003341 putative metal binding site [ion binding]; other site 314225003342 ribonuclease R; Region: RNase_R; TIGR02063 314225003343 RNB domain; Region: RNB; pfam00773 314225003344 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 314225003345 RNA binding site [nucleotide binding]; other site 314225003346 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 314225003347 putative catalytic residues [active] 314225003348 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 314225003349 Ligand Binding Site [chemical binding]; other site 314225003350 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 314225003351 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 314225003352 E3 interaction surface; other site 314225003353 lipoyl attachment site [posttranslational modification]; other site 314225003354 e3 binding domain; Region: E3_binding; pfam02817 314225003355 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 314225003356 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 314225003357 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 314225003358 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 314225003359 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 314225003360 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 314225003361 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 314225003362 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 314225003363 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 314225003364 active site 314225003365 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 314225003366 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 314225003367 TrkA-N domain; Region: TrkA_N; pfam02254 314225003368 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 314225003369 Domain of unknown function DUF11; Region: DUF11; cl17728 314225003370 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4719 314225003371 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 314225003372 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 314225003373 homodimer interface [polypeptide binding]; other site 314225003374 substrate-cofactor binding pocket; other site 314225003375 pyridoxal 5'-phosphate binding site [chemical binding]; other site 314225003376 catalytic residue [active] 314225003377 Transglycosylase SLT domain; Region: SLT_2; pfam13406 314225003378 murein hydrolase B; Provisional; Region: PRK10760; cl17906 314225003379 Sporulation related domain; Region: SPOR; pfam05036 314225003380 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 314225003381 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 314225003382 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 314225003383 thymidylate kinase; Validated; Region: tmk; PRK00698 314225003384 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 314225003385 TMP-binding site; other site 314225003386 ATP-binding site [chemical binding]; other site 314225003387 DNA polymerase III subunit delta'; Validated; Region: PRK07471 314225003388 DNA polymerase III subunit delta'; Validated; Region: PRK08485 314225003389 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 314225003390 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 314225003391 active site 314225003392 HIGH motif; other site 314225003393 KMSKS motif; other site 314225003394 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 314225003395 tRNA binding surface [nucleotide binding]; other site 314225003396 anticodon binding site; other site 314225003397 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 314225003398 active site 314225003399 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 314225003400 putative hydrolase; Provisional; Region: PRK02113 314225003401 acetylornithine deacetylase; Provisional; Region: PRK07522 314225003402 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 314225003403 metal binding site [ion binding]; metal-binding site 314225003404 putative dimer interface [polypeptide binding]; other site 314225003405 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 314225003406 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 314225003407 homodimer interface [polypeptide binding]; other site 314225003408 metal binding site [ion binding]; metal-binding site 314225003409 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 314225003410 homodimer interface [polypeptide binding]; other site 314225003411 active site 314225003412 putative chemical substrate binding site [chemical binding]; other site 314225003413 metal binding site [ion binding]; metal-binding site 314225003414 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 314225003415 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 314225003416 HflX GTPase family; Region: HflX; cd01878 314225003417 G1 box; other site 314225003418 GTP/Mg2+ binding site [chemical binding]; other site 314225003419 Switch I region; other site 314225003420 G2 box; other site 314225003421 G3 box; other site 314225003422 Switch II region; other site 314225003423 G4 box; other site 314225003424 G5 box; other site 314225003425 RNA-binding protein Hfq; Provisional; Region: PRK14091 314225003426 bacterial Hfq-like; Region: Hfq; cd01716 314225003427 hexamer interface [polypeptide binding]; other site 314225003428 Sm1 motif; other site 314225003429 RNA binding site [nucleotide binding]; other site 314225003430 Sm2 motif; other site 314225003431 bacterial Hfq-like; Region: Hfq; cd01716 314225003432 hexamer interface [polypeptide binding]; other site 314225003433 Sm1 motif; other site 314225003434 RNA binding site [nucleotide binding]; other site 314225003435 Sm2 motif; other site 314225003436 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 314225003437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 314225003438 active site 314225003439 phosphorylation site [posttranslational modification] 314225003440 intermolecular recognition site; other site 314225003441 dimerization interface [polypeptide binding]; other site 314225003442 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 314225003443 Walker A motif; other site 314225003444 ATP binding site [chemical binding]; other site 314225003445 Walker B motif; other site 314225003446 arginine finger; other site 314225003447 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 314225003448 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 314225003449 dimerization interface [polypeptide binding]; other site 314225003450 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 314225003451 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 314225003452 dimer interface [polypeptide binding]; other site 314225003453 phosphorylation site [posttranslational modification] 314225003454 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 314225003455 ATP binding site [chemical binding]; other site 314225003456 Mg2+ binding site [ion binding]; other site 314225003457 G-X-G motif; other site 314225003458 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 314225003459 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 314225003460 active site 314225003461 phosphorylation site [posttranslational modification] 314225003462 intermolecular recognition site; other site 314225003463 dimerization interface [polypeptide binding]; other site 314225003464 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 314225003465 Walker A motif; other site 314225003466 ATP binding site [chemical binding]; other site 314225003467 Walker B motif; other site 314225003468 arginine finger; other site 314225003469 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 314225003470 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 314225003471 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 314225003472 putative active site [active] 314225003473 heme pocket [chemical binding]; other site 314225003474 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 314225003475 dimer interface [polypeptide binding]; other site 314225003476 phosphorylation site [posttranslational modification] 314225003477 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 314225003478 ATP binding site [chemical binding]; other site 314225003479 Mg2+ binding site [ion binding]; other site 314225003480 G-X-G motif; other site 314225003481 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 314225003482 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 314225003483 FMN binding site [chemical binding]; other site 314225003484 active site 314225003485 catalytic residues [active] 314225003486 substrate binding site [chemical binding]; other site 314225003487 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 314225003488 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 314225003489 substrate binding site; other site 314225003490 dimer interface; other site 314225003491 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 314225003492 homotrimer interaction site [polypeptide binding]; other site 314225003493 zinc binding site [ion binding]; other site 314225003494 CDP-binding sites; other site 314225003495 Competence-damaged protein; Region: CinA; pfam02464 314225003496 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 314225003497 putative coenzyme Q binding site [chemical binding]; other site 314225003498 lipoyl synthase; Provisional; Region: PRK05481 314225003499 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 314225003500 FeS/SAM binding site; other site 314225003501 Domain of unknown function (DUF897); Region: DUF897; pfam05982 314225003502 CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cl09827 314225003503 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 314225003504 active site clefts [active] 314225003505 zinc binding site [ion binding]; other site 314225003506 dimer interface [polypeptide binding]; other site 314225003507 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 314225003508 putative metal binding site [ion binding]; other site 314225003509 Uncharacterized conserved protein [Function unknown]; Region: COG1432 314225003510 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 314225003511 DNA gyrase subunit A; Validated; Region: PRK05560 314225003512 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 314225003513 CAP-like domain; other site 314225003514 active site 314225003515 primary dimer interface [polypeptide binding]; other site 314225003516 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 314225003517 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 314225003518 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 314225003519 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 314225003520 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 314225003521 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 314225003522 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 314225003523 active site 314225003524 iron coordination sites [ion binding]; other site 314225003525 substrate binding pocket [chemical binding]; other site 314225003526 YhhN-like protein; Region: YhhN; pfam07947 314225003527 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 314225003528 Glucose inhibited division protein A; Region: GIDA; pfam01134 314225003529 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 314225003530 Ca2+ binding site [ion binding]; other site 314225003531 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 314225003532 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 314225003533 TadE-like protein; Region: TadE; pfam07811 314225003534 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 314225003535 TadE-like protein; Region: TadE; pfam07811 314225003536 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 314225003537 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 314225003538 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 314225003539 metal ion-dependent adhesion site (MIDAS); other site 314225003540 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 314225003541 TadE-like protein; Region: TadE; pfam07811 314225003542 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 314225003543 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 314225003544 E3 interaction surface; other site 314225003545 lipoyl attachment site [posttranslational modification]; other site 314225003546 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 314225003547 alpha subunit interface [polypeptide binding]; other site 314225003548 TPP binding site [chemical binding]; other site 314225003549 heterodimer interface [polypeptide binding]; other site 314225003550 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 314225003551 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 314225003552 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 314225003553 tetramer interface [polypeptide binding]; other site 314225003554 TPP-binding site [chemical binding]; other site 314225003555 heterodimer interface [polypeptide binding]; other site 314225003556 phosphorylation loop region [posttranslational modification] 314225003557 Septum formation initiator; Region: DivIC; pfam04977 314225003558 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 314225003559 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 314225003560 dimer interface [polypeptide binding]; other site 314225003561 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 314225003562 active site 314225003563 Fe binding site [ion binding]; other site 314225003564 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 314225003565 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 314225003566 Zn binding site [ion binding]; other site 314225003567 mechanosensitive channel MscS; Provisional; Region: PRK10334 314225003568 Conserved TM helix; Region: TM_helix; pfam05552 314225003569 Mechanosensitive ion channel; Region: MS_channel; pfam00924 314225003570 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 314225003571 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 314225003572 putative substrate translocation pore; other site 314225003573 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 314225003574 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 314225003575 nitrilase; Region: PLN02798 314225003576 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 314225003577 putative active site [active] 314225003578 catalytic triad [active] 314225003579 dimer interface [polypeptide binding]; other site 314225003580 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 314225003581 GSH binding site [chemical binding]; other site 314225003582 catalytic residues [active] 314225003583 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 314225003584 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 314225003585 putative dimer interface [polypeptide binding]; other site 314225003586 CTP synthetase; Validated; Region: pyrG; PRK05380 314225003587 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 314225003588 Catalytic site [active] 314225003589 active site 314225003590 UTP binding site [chemical binding]; other site 314225003591 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 314225003592 active site 314225003593 putative oxyanion hole; other site 314225003594 catalytic triad [active] 314225003595 protein translocase, SecG subunit; Region: secG; TIGR00810 314225003596 triosephosphate isomerase; Provisional; Region: PRK14565 314225003597 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 314225003598 substrate binding site [chemical binding]; other site 314225003599 dimer interface [polypeptide binding]; other site 314225003600 catalytic triad [active] 314225003601 SurA N-terminal domain; Region: SurA_N_3; cl07813 314225003602 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 314225003603 anthranilate synthase component I; Provisional; Region: PRK13573 314225003604 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 314225003605 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 314225003606 Predicted periplasmic protein [Function unknown]; Region: COG3698 314225003607 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 314225003608 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 314225003609 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 314225003610 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 314225003611 glutamine binding [chemical binding]; other site 314225003612 catalytic triad [active] 314225003613 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 314225003614 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 314225003615 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 314225003616 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 314225003617 active site 314225003618 ribulose/triose binding site [chemical binding]; other site 314225003619 phosphate binding site [ion binding]; other site 314225003620 substrate (anthranilate) binding pocket [chemical binding]; other site 314225003621 product (indole) binding pocket [chemical binding]; other site 314225003622 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 314225003623 trimer interface [polypeptide binding]; other site 314225003624 dimer interface [polypeptide binding]; other site 314225003625 putative active site [active] 314225003626 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 314225003627 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 314225003628 dimer interface [polypeptide binding]; other site 314225003629 putative functional site; other site 314225003630 putative MPT binding site; other site 314225003631 LexA repressor; Validated; Region: PRK00215 314225003632 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 314225003633 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 314225003634 Catalytic site [active] 314225003635 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 314225003636 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 314225003637 Competence protein; Region: Competence; pfam03772 314225003638 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 314225003639 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 314225003640 active site 314225003641 HIGH motif; other site 314225003642 nucleotide binding site [chemical binding]; other site 314225003643 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 314225003644 active site 314225003645 KMSKS motif; other site 314225003646 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 314225003647 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 314225003648 dimer interface [polypeptide binding]; other site 314225003649 active site 314225003650 citrylCoA binding site [chemical binding]; other site 314225003651 NADH binding [chemical binding]; other site 314225003652 cationic pore residues; other site 314225003653 oxalacetate/citrate binding site [chemical binding]; other site 314225003654 coenzyme A binding site [chemical binding]; other site 314225003655 catalytic triad [active] 314225003656 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 314225003657 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 314225003658 dimer interface [polypeptide binding]; other site 314225003659 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 314225003660 ATP binding site [chemical binding]; other site 314225003661 Mg2+ binding site [ion binding]; other site 314225003662 G-X-G motif; other site 314225003663 Protein of unknown function (DUF3632); Region: DUF3632; pfam12311 314225003664 chromosome segregation protein; Provisional; Region: PRK02224 314225003665 Protein of unknown function (DUF1467); Region: DUF1467; pfam07330 314225003666 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 314225003667 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 314225003668 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 314225003669 pantothenate kinase; Reviewed; Region: PRK13318 314225003670 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 314225003671 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 314225003672 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 314225003673 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 314225003674 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 314225003675 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 314225003676 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 314225003677 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 314225003678 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 314225003679 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 314225003680 NADH dehydrogenase subunit 5 C-terminus; Region: NADH5_C; pfam06455 314225003681 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 314225003682 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 314225003683 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 314225003684 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 314225003685 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 314225003686 4Fe-4S binding domain; Region: Fer4; pfam00037 314225003687 4Fe-4S binding domain; Region: Fer4; pfam00037 314225003688 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 314225003689 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 314225003690 NADH dehydrogenase subunit G; Validated; Region: PRK09130 314225003691 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 314225003692 catalytic loop [active] 314225003693 iron binding site [ion binding]; other site 314225003694 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 314225003695 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 314225003696 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 314225003697 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 314225003698 SLBB domain; Region: SLBB; pfam10531 314225003699 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 314225003700 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 314225003701 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 314225003702 putative dimer interface [polypeptide binding]; other site 314225003703 [2Fe-2S] cluster binding site [ion binding]; other site 314225003704 NADH dehydrogenase subunit D; Validated; Region: PRK06075 314225003705 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 314225003706 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 314225003707 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 314225003708 NADH dehydrogenase subunit B; Validated; Region: PRK06411 314225003709 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 314225003710 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 314225003711 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 314225003712 NAD(P) binding site [chemical binding]; other site 314225003713 catalytic residues [active] 314225003714 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 314225003715 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 314225003716 dimer interface [polypeptide binding]; other site 314225003717 active site 314225003718 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 314225003719 Bacterial SH3 domain; Region: SH3_4; pfam06347 314225003720 Bacterial SH3 domain; Region: SH3_4; pfam06347 314225003721 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 314225003722 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 314225003723 dimerization interface [polypeptide binding]; other site 314225003724 ligand binding site [chemical binding]; other site 314225003725 NADP binding site [chemical binding]; other site 314225003726 catalytic site [active] 314225003727 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 314225003728 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 314225003729 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 314225003730 NAD binding site [chemical binding]; other site 314225003731 homotetramer interface [polypeptide binding]; other site 314225003732 homodimer interface [polypeptide binding]; other site 314225003733 substrate binding site [chemical binding]; other site 314225003734 active site 314225003735 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 314225003736 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 314225003737 dimer interface [polypeptide binding]; other site 314225003738 active site 314225003739 3-hydroxydecanoyl-(acyl carrier protein) dehydratase; Validated; Region: PRK05174 314225003740 active site 2 [active] 314225003741 active site 1 [active] 314225003742 Methyltransferase domain; Region: Methyltransf_31; pfam13847 314225003743 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 314225003744 S-adenosylmethionine binding site [chemical binding]; other site 314225003745 peptide chain release factor 2; Validated; Region: prfB; PRK00578 314225003746 This domain is found in peptide chain release factors; Region: PCRF; smart00937 314225003747 RF-1 domain; Region: RF-1; pfam00472 314225003748 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 314225003749 Transglycosylase; Region: Transgly; pfam00912 314225003750 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 314225003751 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 314225003752 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 314225003753 active site 314225003754 metal binding site [ion binding]; metal-binding site 314225003755 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 314225003756 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 314225003757 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 314225003758 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 314225003759 Methyltransferase domain; Region: Methyltransf_31; pfam13847 314225003760 S-adenosylmethionine binding site [chemical binding]; other site 314225003761 ATP-grasp domain; Region: ATP-grasp_4; cl17255 314225003762 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 314225003763 C factor cell-cell signaling protein; Provisional; Region: PRK09009 314225003764 NADP binding site [chemical binding]; other site 314225003765 homodimer interface [polypeptide binding]; other site 314225003766 active site 314225003767 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 314225003768 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 314225003769 catalytic loop [active] 314225003770 iron binding site [ion binding]; other site 314225003771 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 314225003772 CoenzymeA binding site [chemical binding]; other site 314225003773 subunit interaction site [polypeptide binding]; other site 314225003774 PHB binding site; other site 314225003775 Predicted ATPase [General function prediction only]; Region: COG1485 314225003776 enoyl-CoA hydratase; Validated; Region: PRK08788 314225003777 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 314225003778 substrate binding site [chemical binding]; other site 314225003779 oxyanion hole (OAH) forming residues; other site 314225003780 trimer interface [polypeptide binding]; other site 314225003781 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 314225003782 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 314225003783 active site 314225003784 dimer interface [polypeptide binding]; other site 314225003785 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 314225003786 Ligand Binding Site [chemical binding]; other site 314225003787 Molecular Tunnel; other site 314225003788 exosortase A; Region: exosortase_1; TIGR03109 314225003789 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 314225003790 EpsI family protein; Region: EpsI_fam; TIGR02914 314225003791 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 314225003792 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 314225003793 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 314225003794 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941 314225003795 polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006 314225003796 putative active site [active] 314225003797 putative catalytic site [active] 314225003798 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 314225003799 AAA ATPase domain; Region: AAA_16; pfam13191 314225003800 Preprotein translocase subunit; Region: YajC; cl00806 314225003801 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 314225003802 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 314225003803 Chain length determinant protein; Region: Wzz; cl15801 314225003804 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 314225003805 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 314225003806 SLBB domain; Region: SLBB; pfam10531 314225003807 pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099 314225003808 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 314225003809 dimer interface [polypeptide binding]; other site 314225003810 active site 314225003811 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 314225003812 catalytic residues [active] 314225003813 substrate binding site [chemical binding]; other site 314225003814 acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098 314225003815 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 314225003816 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_6; cd05922 314225003817 acyl-activating enzyme (AAE) consensus motif; other site 314225003818 acyl-activating enzyme (AAE) consensus motif; other site 314225003819 putative AMP binding site [chemical binding]; other site 314225003820 putative active site [active] 314225003821 putative CoA binding site [chemical binding]; other site 314225003822 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 314225003823 exosortase A system-associated hydrolase 2; Region: hydr2_PEP; TIGR03101 314225003824 exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100 314225003825 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 314225003826 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 314225003827 putative carbohydrate kinase; Provisional; Region: PRK10565 314225003828 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 314225003829 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 314225003830 putative substrate binding site [chemical binding]; other site 314225003831 putative ATP binding site [chemical binding]; other site 314225003832 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 314225003833 N-formylglutamate amidohydrolase; Region: FGase; cl01522 314225003834 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 314225003835 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 314225003836 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 314225003837 putative active site [active] 314225003838 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 314225003839 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 314225003840 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 314225003841 active site 314225003842 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 314225003843 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 314225003844 N-acetyl-D-glucosamine binding site [chemical binding]; other site 314225003845 catalytic residue [active] 314225003846 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 314225003847 MPT binding site; other site 314225003848 trimer interface [polypeptide binding]; other site 314225003849 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 314225003850 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 314225003851 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 314225003852 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 314225003853 FeS/SAM binding site; other site 314225003854 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 314225003855 putative acyl-CoA synthetase; Provisional; Region: PRK06018 314225003856 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 314225003857 dimer interface [polypeptide binding]; other site 314225003858 acyl-activating enzyme (AAE) consensus motif; other site 314225003859 putative active site [active] 314225003860 AMP binding site [chemical binding]; other site 314225003861 putative CoA binding site [chemical binding]; other site 314225003862 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 314225003863 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 314225003864 putative active site [active] 314225003865 putative PHP Thumb interface [polypeptide binding]; other site 314225003866 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 314225003867 generic binding surface I; other site 314225003868 generic binding surface II; other site 314225003869 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 314225003870 catalytic residues [active] 314225003871 dimer interface [polypeptide binding]; other site 314225003872 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 314225003873 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 314225003874 Walker A/P-loop; other site 314225003875 ATP binding site [chemical binding]; other site 314225003876 Q-loop/lid; other site 314225003877 ABC transporter signature motif; other site 314225003878 Walker B; other site 314225003879 D-loop; other site 314225003880 H-loop/switch region; other site 314225003881 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 314225003882 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 314225003883 FtsX-like permease family; Region: FtsX; pfam02687 314225003884 amidophosphoribosyltransferase; Provisional; Region: PRK09123 314225003885 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 314225003886 active site 314225003887 tetramer interface [polypeptide binding]; other site 314225003888 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 314225003889 active site 314225003890 short chain dehydrogenase; Provisional; Region: PRK08703 314225003891 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 314225003892 NAD(P) binding site [chemical binding]; other site 314225003893 active site 314225003894 PilZ domain; Region: PilZ; pfam07238 314225003895 Beta-lactamase; Region: Beta-lactamase; pfam00144 314225003896 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 314225003897 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 314225003898 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 314225003899 S-adenosylmethionine binding site [chemical binding]; other site 314225003900 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 314225003901 DNA photolyase; Region: DNA_photolyase; pfam00875 314225003902 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 314225003903 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 314225003904 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 314225003905 TPP-binding site [chemical binding]; other site 314225003906 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 314225003907 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 314225003908 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 314225003909 dimer interface [polypeptide binding]; other site 314225003910 PYR/PP interface [polypeptide binding]; other site 314225003911 TPP binding site [chemical binding]; other site 314225003912 substrate binding site [chemical binding]; other site 314225003913 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 314225003914 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 314225003915 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 314225003916 putative active site [active] 314225003917 Ap4A binding site [chemical binding]; other site 314225003918 nudix motif; other site 314225003919 putative metal binding site [ion binding]; other site 314225003920 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 314225003921 binding surface 314225003922 Tetratricopeptide repeat; Region: TPR_16; pfam13432 314225003923 TPR motif; other site 314225003924 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 314225003925 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 314225003926 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 314225003927 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 314225003928 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 314225003929 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 314225003930 active site 314225003931 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 314225003932 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 314225003933 Peptidase family M28; Region: Peptidase_M28; pfam04389 314225003934 metal binding site [ion binding]; metal-binding site 314225003935 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 314225003936 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 314225003937 NAD(P) binding site [chemical binding]; other site 314225003938 active site 314225003939 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 314225003940 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 314225003941 Penicillinase repressor; Region: Pencillinase_R; pfam03965 314225003942 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 314225003943 active site 314225003944 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 314225003945 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 314225003946 L-aspartate oxidase; Provisional; Region: PRK06175 314225003947 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 314225003948 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 314225003949 putative SdhC subunit interface [polypeptide binding]; other site 314225003950 putative proximal heme binding site [chemical binding]; other site 314225003951 putative Iron-sulfur protein interface [polypeptide binding]; other site 314225003952 putative proximal quinone binding site; other site 314225003953 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 314225003954 Iron-sulfur protein interface; other site 314225003955 proximal quinone binding site [chemical binding]; other site 314225003956 SdhD (CybS) interface [polypeptide binding]; other site 314225003957 proximal heme binding site [chemical binding]; other site 314225003958 classical (c) SDRs; Region: SDR_c; cd05233 314225003959 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 314225003960 NAD(P) binding site [chemical binding]; other site 314225003961 active site 314225003962 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 314225003963 GIY-YIG motif/motif A; other site 314225003964 putative active site [active] 314225003965 putative metal binding site [ion binding]; other site 314225003966 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 314225003967 Protein of unknown function (DUF2459); Region: DUF2459; pfam09601 314225003968 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 314225003969 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 314225003970 substrate binding site [chemical binding]; other site 314225003971 oxyanion hole (OAH) forming residues; other site 314225003972 trimer interface [polypeptide binding]; other site 314225003973 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 314225003974 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 314225003975 NAD(P) binding site [chemical binding]; other site 314225003976 active site 314225003977 Competence-damaged protein; Region: CinA; pfam02464 314225003978 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 314225003979 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 314225003980 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 314225003981 nucleotide binding pocket [chemical binding]; other site 314225003982 K-X-D-G motif; other site 314225003983 catalytic site [active] 314225003984 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 314225003985 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 314225003986 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 314225003987 Dimer interface [polypeptide binding]; other site 314225003988 BRCT sequence motif; other site 314225003989 WYL domain; Region: WYL; pfam13280 314225003990 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 314225003991 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 314225003992 Walker A/P-loop; other site 314225003993 ATP binding site [chemical binding]; other site 314225003994 Q-loop/lid; other site 314225003995 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 314225003996 ABC transporter signature motif; other site 314225003997 Walker B; other site 314225003998 D-loop; other site 314225003999 H-loop/switch region; other site 314225004000 Outer membrane lipoprotein; Region: YfiO; pfam13525 314225004001 gamma-glutamyl kinase; Provisional; Region: PRK05429 314225004002 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 314225004003 nucleotide binding site [chemical binding]; other site 314225004004 homotetrameric interface [polypeptide binding]; other site 314225004005 putative phosphate binding site [ion binding]; other site 314225004006 putative allosteric binding site; other site 314225004007 PUA domain; Region: PUA; pfam01472 314225004008 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 314225004009 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 314225004010 putative catalytic cysteine [active] 314225004011 Transposase; Region: HTH_Tnp_1; pfam01527 314225004012 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 314225004013 HTH-like domain; Region: HTH_21; pfam13276 314225004014 Integrase core domain; Region: rve; pfam00665 314225004015 Integrase core domain; Region: rve_3; pfam13683 314225004016 GTP-binding protein LepA; Provisional; Region: PRK05433 314225004017 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 314225004018 G1 box; other site 314225004019 putative GEF interaction site [polypeptide binding]; other site 314225004020 GTP/Mg2+ binding site [chemical binding]; other site 314225004021 Switch I region; other site 314225004022 G2 box; other site 314225004023 G3 box; other site 314225004024 Switch II region; other site 314225004025 G4 box; other site 314225004026 G5 box; other site 314225004027 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 314225004028 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 314225004029 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 314225004030 Electron transfer DM13; Region: DM13; pfam10517 314225004031 PAS domain; Region: PAS_9; pfam13426 314225004032 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 314225004033 putative active site [active] 314225004034 heme pocket [chemical binding]; other site 314225004035 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 314225004036 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 314225004037 metal binding site [ion binding]; metal-binding site 314225004038 active site 314225004039 I-site; other site 314225004040 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 314225004041 PAS domain; Region: PAS_9; pfam13426 314225004042 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 314225004043 putative active site [active] 314225004044 heme pocket [chemical binding]; other site 314225004045 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 314225004046 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 314225004047 metal binding site [ion binding]; metal-binding site 314225004048 active site 314225004049 I-site; other site 314225004050 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 314225004051 PilZ domain; Region: PilZ; pfam07238 314225004052 ferredoxin-NADP+ reductase; Region: PLN02852 314225004053 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 314225004054 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 314225004055 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 314225004056 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 314225004057 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 314225004058 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 314225004059 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 314225004060 active site 314225004061 putative substrate binding pocket [chemical binding]; other site 314225004062 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 314225004063 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 314225004064 NAD(P) binding site [chemical binding]; other site 314225004065 active site 314225004066 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 314225004067 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 314225004068 putative NAD(P) binding site [chemical binding]; other site 314225004069 Protein of unknown function (DUF2855); Region: DUF2855; pfam11017 314225004070 DNA polymerase III subunit beta; Validated; Region: PRK05643 314225004071 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 314225004072 putative DNA binding surface [nucleotide binding]; other site 314225004073 dimer interface [polypeptide binding]; other site 314225004074 beta-clamp/clamp loader binding surface; other site 314225004075 beta-clamp/translesion DNA polymerase binding surface; other site 314225004076 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 314225004077 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 314225004078 NAD(P) binding site [chemical binding]; other site 314225004079 homotetramer interface [polypeptide binding]; other site 314225004080 homodimer interface [polypeptide binding]; other site 314225004081 active site 314225004082 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 314225004083 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 314225004084 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 314225004085 dimer interface [polypeptide binding]; other site 314225004086 catalytic triad [active] 314225004087 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 314225004088 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 314225004089 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 314225004090 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 314225004091 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 314225004092 putative C-terminal domain interface [polypeptide binding]; other site 314225004093 putative GSH binding site (G-site) [chemical binding]; other site 314225004094 putative dimer interface [polypeptide binding]; other site 314225004095 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 314225004096 N-terminal domain interface [polypeptide binding]; other site 314225004097 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 314225004098 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 314225004099 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 314225004100 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 314225004101 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 314225004102 AMP nucleosidase; Provisional; Region: PRK08292 314225004103 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 314225004104 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 314225004105 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 314225004106 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 314225004107 NAD(P) binding site [chemical binding]; other site 314225004108 active site 314225004109 Abortive infection C-terminus; Region: Abi_C; pfam14355 314225004110 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 314225004111 ATP-grasp domain; Region: ATP-grasp_4; cl17255 314225004112 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 314225004113 Uncharacterized conserved protein [Function unknown]; Region: COG3391 314225004114 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 314225004115 Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461 314225004116 active site 314225004117 Zn binding site [ion binding]; other site 314225004118 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 314225004119 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 314225004120 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 314225004121 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 314225004122 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 314225004123 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 314225004124 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 314225004125 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 314225004126 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 314225004127 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 314225004128 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 314225004129 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 314225004130 Predicted amidohydrolase [General function prediction only]; Region: COG0388 314225004131 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 314225004132 putative active site [active] 314225004133 catalytic triad [active] 314225004134 putative dimer interface [polypeptide binding]; other site 314225004135 16S rRNA processing protein RimM; Region: 16S_RimM; TIGR02273 314225004136 RimM N-terminal domain; Region: RimM; pfam01782 314225004137 PRC-barrel domain; Region: PRC; pfam05239 314225004138 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 314225004139 signal recognition particle protein; Provisional; Region: PRK10867 314225004140 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 314225004141 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 314225004142 P loop; other site 314225004143 GTP binding site [chemical binding]; other site 314225004144 Signal peptide binding domain; Region: SRP_SPB; pfam02978 314225004145 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 314225004146 TIGR02300 family protein; Region: FYDLN_acid 314225004147 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 314225004148 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 314225004149 hinge; other site 314225004150 active site 314225004151 cytidylate kinase; Provisional; Region: cmk; PRK00023 314225004152 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 314225004153 CMP-binding site; other site 314225004154 The sites determining sugar specificity; other site 314225004155 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 314225004156 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 314225004157 RNA binding site [nucleotide binding]; other site 314225004158 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 314225004159 RNA binding site [nucleotide binding]; other site 314225004160 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 314225004161 RNA binding site [nucleotide binding]; other site 314225004162 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 314225004163 RNA binding site [nucleotide binding]; other site 314225004164 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 314225004165 RNA binding site [nucleotide binding]; other site 314225004166 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 314225004167 RNA binding site [nucleotide binding]; other site 314225004168 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 314225004169 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 314225004170 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 314225004171 NAD(P) binding site [chemical binding]; other site 314225004172 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 314225004173 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 314225004174 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 314225004175 ATP synthase subunit C; Region: ATP-synt_C; cl00466 314225004176 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 314225004177 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 314225004178 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 314225004179 Protein of unknown function (DUF1318); Region: DUF1318; pfam07027 314225004180 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 314225004181 Dicarboxylate transport; Region: DctA-YdbH; pfam11739 314225004182 hypothetical protein; Reviewed; Region: PRK00024 314225004183 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 314225004184 MPN+ (JAMM) motif; other site 314225004185 Zinc-binding site [ion binding]; other site 314225004186 adenylosuccinate lyase; Provisional; Region: PRK07492 314225004187 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 314225004188 tetramer interface [polypeptide binding]; other site 314225004189 active site 314225004190 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 314225004191 active site 314225004192 dimer interface [polypeptide binding]; other site 314225004193 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 314225004194 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 314225004195 active site 314225004196 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 314225004197 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 314225004198 pyridoxal 5'-phosphate binding site [chemical binding]; other site 314225004199 catalytic residue [active] 314225004200 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 314225004201 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 314225004202 substrate binding site [chemical binding]; other site 314225004203 active site 314225004204 catalytic residues [active] 314225004205 heterodimer interface [polypeptide binding]; other site 314225004206 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 314225004207 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 314225004208 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 314225004209 muropeptide transporter; Validated; Region: ampG; cl17669 314225004210 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 314225004211 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 314225004212 RNA binding surface [nucleotide binding]; other site 314225004213 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 314225004214 active site 314225004215 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 314225004216 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 314225004217 S-adenosylmethionine binding site [chemical binding]; other site 314225004218 Uncharacterized conserved protein [Function unknown]; Region: COG3791 314225004219 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 314225004220 Family description; Region: UvrD_C_2; pfam13538 314225004221 hypothetical protein; Provisional; Region: PRK13559 314225004222 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 314225004223 putative active site [active] 314225004224 heme pocket [chemical binding]; other site 314225004225 HWE histidine kinase; Region: HWE_HK; smart00911 314225004226 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 314225004227 phosphorylation site [posttranslational modification] 314225004228 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 314225004229 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 314225004230 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 314225004231 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 314225004232 ATP binding site [chemical binding]; other site 314225004233 Mg++ binding site [ion binding]; other site 314225004234 motif III; other site 314225004235 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 314225004236 nucleotide binding region [chemical binding]; other site 314225004237 ATP-binding site [chemical binding]; other site 314225004238 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 314225004239 FAD binding domain; Region: FAD_binding_4; pfam01565 314225004240 SapC; Region: SapC; pfam07277 314225004241 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 314225004242 Response regulator receiver domain; Region: Response_reg; pfam00072 314225004243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 314225004244 active site 314225004245 phosphorylation site [posttranslational modification] 314225004246 intermolecular recognition site; other site 314225004247 dimerization interface [polypeptide binding]; other site 314225004248 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 314225004249 NADH(P)-binding; Region: NAD_binding_10; pfam13460 314225004250 NAD binding site [chemical binding]; other site 314225004251 substrate binding site [chemical binding]; other site 314225004252 putative active site [active] 314225004253 isocitrate dehydrogenase; Validated; Region: PRK08299 314225004254 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 314225004255 Predicted amidohydrolase [General function prediction only]; Region: COG0388 314225004256 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 314225004257 putative active site [active] 314225004258 catalytic triad [active] 314225004259 putative dimer interface [polypeptide binding]; other site 314225004260 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 314225004261 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 314225004262 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 314225004263 TrkA-N domain; Region: TrkA_N; pfam02254 314225004264 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 314225004265 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 314225004266 motif 1; other site 314225004267 active site 314225004268 motif 2; other site 314225004269 motif 3; other site 314225004270 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 314225004271 DHHA1 domain; Region: DHHA1; pfam02272 314225004272 Methyltransferase domain; Region: Methyltransf_31; pfam13847 314225004273 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 314225004274 S-adenosylmethionine binding site [chemical binding]; other site 314225004275 recombinase A; Provisional; Region: recA; PRK09354 314225004276 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 314225004277 hexamer interface [polypeptide binding]; other site 314225004278 Walker A motif; other site 314225004279 ATP binding site [chemical binding]; other site 314225004280 Walker B motif; other site 314225004281 PAS domain; Region: PAS; smart00091 314225004282 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 314225004283 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 314225004284 dimer interface [polypeptide binding]; other site 314225004285 phosphorylation site [posttranslational modification] 314225004286 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 314225004287 ATP binding site [chemical binding]; other site 314225004288 Mg2+ binding site [ion binding]; other site 314225004289 G-X-G motif; other site 314225004290 Response regulator receiver domain; Region: Response_reg; pfam00072 314225004291 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 314225004292 active site 314225004293 phosphorylation site [posttranslational modification] 314225004294 intermolecular recognition site; other site 314225004295 dimerization interface [polypeptide binding]; other site 314225004296 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 314225004297 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 314225004298 SmpB-tmRNA interface; other site 314225004299 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 314225004300 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 314225004301 putative active site [active] 314225004302 Zn binding site [ion binding]; other site 314225004303 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 314225004304 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 314225004305 dimer interface [polypeptide binding]; other site 314225004306 active site 314225004307 catalytic residue [active] 314225004308 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 314225004309 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 314225004310 N-acetyl-D-glucosamine binding site [chemical binding]; other site 314225004311 catalytic residue [active] 314225004312 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 314225004313 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 314225004314 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 314225004315 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 314225004316 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 314225004317 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 314225004318 FeS/SAM binding site; other site 314225004319 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 314225004320 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 314225004321 Methyltransferase domain; Region: Methyltransf_23; pfam13489 314225004322 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 314225004323 S-adenosylmethionine binding site [chemical binding]; other site 314225004324 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 314225004325 MOSC domain; Region: MOSC; pfam03473 314225004326 amino acid transporter; Region: 2A0306; TIGR00909 314225004327 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 314225004328 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 314225004329 NAD(P) binding site [chemical binding]; other site 314225004330 active site 314225004331 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 314225004332 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 314225004333 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 314225004334 Moco binding site; other site 314225004335 metal coordination site [ion binding]; other site 314225004336 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 314225004337 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 314225004338 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 314225004339 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 314225004340 S-adenosylmethionine binding site [chemical binding]; other site 314225004341 argininosuccinate synthase; Provisional; Region: PRK13820 314225004342 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 314225004343 ANP binding site [chemical binding]; other site 314225004344 Substrate Binding Site II [chemical binding]; other site 314225004345 Substrate Binding Site I [chemical binding]; other site 314225004346 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 314225004347 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 314225004348 A domain in the BMP inhibitor chordin and in microbial proteins; Region: CHRD; smart00754 314225004349 WYL domain; Region: WYL; pfam13280 314225004350 Transposase; Region: HTH_Tnp_1; pfam01527 314225004351 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 314225004352 HTH-like domain; Region: HTH_21; pfam13276 314225004353 Integrase core domain; Region: rve; pfam00665 314225004354 Integrase core domain; Region: rve_3; pfam13683 314225004355 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 314225004356 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 314225004357 putative active site [active] 314225004358 putative metal-binding site [ion binding]; other site 314225004359 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 314225004360 H-loop/switch region; other site 314225004361 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 314225004362 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 314225004363 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 314225004364 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 314225004365 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 314225004366 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 314225004367 metal binding site [ion binding]; metal-binding site 314225004368 active site 314225004369 I-site; other site 314225004370 Ras GTPase Activating Domain; Region: RasGAP; cl02569 314225004371 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 314225004372 catalytic residue [active] 314225004373 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 314225004374 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 314225004375 active site 314225004376 Zn binding site [ion binding]; other site 314225004377 Protein of unknown function (DUF3380); Region: DUF3380; pfam11860 314225004378 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 314225004379 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 314225004380 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 314225004381 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 314225004382 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 314225004383 Walker A/P-loop; other site 314225004384 ATP binding site [chemical binding]; other site 314225004385 Q-loop/lid; other site 314225004386 ABC transporter signature motif; other site 314225004387 Walker B; other site 314225004388 D-loop; other site 314225004389 H-loop/switch region; other site 314225004390 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 314225004391 ABC-ATPase subunit interface; other site 314225004392 dimer interface [polypeptide binding]; other site 314225004393 putative PBP binding regions; other site 314225004394 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 314225004395 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 314225004396 intersubunit interface [polypeptide binding]; other site 314225004397 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 314225004398 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 314225004399 N-terminal plug; other site 314225004400 ligand-binding site [chemical binding]; other site 314225004401 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 314225004402 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 314225004403 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 314225004404 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 314225004405 metal binding site [ion binding]; metal-binding site 314225004406 active site 314225004407 I-site; other site 314225004408 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 314225004409 malate dehydrogenase; Reviewed; Region: PRK06223 314225004410 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 314225004411 NAD(P) binding site [chemical binding]; other site 314225004412 dimer interface [polypeptide binding]; other site 314225004413 tetramer (dimer of dimers) interface [polypeptide binding]; other site 314225004414 substrate binding site [chemical binding]; other site 314225004415 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 314225004416 CoA binding domain; Region: CoA_binding; smart00881 314225004417 CoA-ligase; Region: Ligase_CoA; pfam00549 314225004418 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 314225004419 GIY-YIG motif/motif A; other site 314225004420 putative active site [active] 314225004421 putative metal binding site [ion binding]; other site 314225004422 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 314225004423 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 314225004424 TPP-binding site [chemical binding]; other site 314225004425 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 314225004426 PYR/PP interface [polypeptide binding]; other site 314225004427 dimer interface [polypeptide binding]; other site 314225004428 TPP binding site [chemical binding]; other site 314225004429 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 314225004430 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 314225004431 E3 interaction surface; other site 314225004432 lipoyl attachment site [posttranslational modification]; other site 314225004433 e3 binding domain; Region: E3_binding; pfam02817 314225004434 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 314225004435 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06115 314225004436 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 314225004437 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 314225004438 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 314225004439 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 314225004440 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 314225004441 putative metal binding site [ion binding]; other site 314225004442 amidase; Provisional; Region: PRK06170 314225004443 Amidase; Region: Amidase; cl11426 314225004444 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 314225004445 Predicted membrane protein [Function unknown]; Region: COG2860 314225004446 UPF0126 domain; Region: UPF0126; pfam03458 314225004447 UPF0126 domain; Region: UPF0126; pfam03458 314225004448 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 314225004449 Beta-lactamase; Region: Beta-lactamase; pfam00144 314225004450 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 314225004451 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 314225004452 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 314225004453 alphaNTD homodimer interface [polypeptide binding]; other site 314225004454 alphaNTD - beta interaction site [polypeptide binding]; other site 314225004455 alphaNTD - beta' interaction site [polypeptide binding]; other site 314225004456 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 314225004457 30S ribosomal protein S11; Validated; Region: PRK05309 314225004458 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 314225004459 30S ribosomal protein S13; Region: bact_S13; TIGR03631 314225004460 adenylate kinase; Reviewed; Region: adk; PRK00279 314225004461 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 314225004462 AMP-binding site [chemical binding]; other site 314225004463 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 314225004464 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 314225004465 SecY translocase; Region: SecY; pfam00344 314225004466 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 314225004467 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 314225004468 23S rRNA binding site [nucleotide binding]; other site 314225004469 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 314225004470 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 314225004471 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 314225004472 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 314225004473 23S rRNA interface [nucleotide binding]; other site 314225004474 L21e interface [polypeptide binding]; other site 314225004475 5S rRNA interface [nucleotide binding]; other site 314225004476 L27 interface [polypeptide binding]; other site 314225004477 L5 interface [polypeptide binding]; other site 314225004478 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 314225004479 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 314225004480 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 314225004481 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 314225004482 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 314225004483 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 314225004484 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 314225004485 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 314225004486 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 314225004487 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 314225004488 RNA binding site [nucleotide binding]; other site 314225004489 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 314225004490 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 314225004491 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 314225004492 putative translocon interaction site; other site 314225004493 23S rRNA interface [nucleotide binding]; other site 314225004494 signal recognition particle (SRP54) interaction site; other site 314225004495 L23 interface [polypeptide binding]; other site 314225004496 trigger factor interaction site; other site 314225004497 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 314225004498 23S rRNA interface [nucleotide binding]; other site 314225004499 5S rRNA interface [nucleotide binding]; other site 314225004500 putative antibiotic binding site [chemical binding]; other site 314225004501 L25 interface [polypeptide binding]; other site 314225004502 L27 interface [polypeptide binding]; other site 314225004503 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 314225004504 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 314225004505 G-X-X-G motif; other site 314225004506 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 314225004507 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 314225004508 putative translocon binding site; other site 314225004509 protein-rRNA interface [nucleotide binding]; other site 314225004510 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 314225004511 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 314225004512 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 314225004513 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 314225004514 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 314225004515 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 314225004516 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 314225004517 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 314225004518 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 314225004519 elongation factor Tu; Reviewed; Region: PRK00049 314225004520 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 314225004521 G1 box; other site 314225004522 GEF interaction site [polypeptide binding]; other site 314225004523 GTP/Mg2+ binding site [chemical binding]; other site 314225004524 Switch I region; other site 314225004525 G2 box; other site 314225004526 G3 box; other site 314225004527 Switch II region; other site 314225004528 G4 box; other site 314225004529 G5 box; other site 314225004530 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 314225004531 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 314225004532 Antibiotic Binding Site [chemical binding]; other site 314225004533 elongation factor G; Reviewed; Region: PRK00007 314225004534 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 314225004535 G1 box; other site 314225004536 putative GEF interaction site [polypeptide binding]; other site 314225004537 GTP/Mg2+ binding site [chemical binding]; other site 314225004538 Switch I region; other site 314225004539 G2 box; other site 314225004540 G3 box; other site 314225004541 Switch II region; other site 314225004542 G4 box; other site 314225004543 G5 box; other site 314225004544 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 314225004545 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 314225004546 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 314225004547 30S ribosomal protein S7; Validated; Region: PRK05302 314225004548 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 314225004549 S17 interaction site [polypeptide binding]; other site 314225004550 S8 interaction site; other site 314225004551 16S rRNA interaction site [nucleotide binding]; other site 314225004552 streptomycin interaction site [chemical binding]; other site 314225004553 23S rRNA interaction site [nucleotide binding]; other site 314225004554 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 314225004555 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 314225004556 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 314225004557 Coenzyme A binding pocket [chemical binding]; other site 314225004558 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 314225004559 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 314225004560 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 314225004561 dimerization interface [polypeptide binding]; other site 314225004562 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 314225004563 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 314225004564 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 314225004565 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 314225004566 TadE-like protein; Region: TadE; pfam07811 314225004567 TadE-like protein; Region: TadE; pfam07811 314225004568 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; cl17260 314225004569 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 314225004570 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 314225004571 putative catalytic residue [active] 314225004572 MgtC family; Region: MgtC; pfam02308 314225004573 O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504 314225004574 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 314225004575 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 314225004576 catalytic residue [active] 314225004577 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 314225004578 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 314225004579 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 314225004580 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 314225004581 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 314225004582 Ligand binding site; other site 314225004583 Putative Catalytic site; other site 314225004584 DXD motif; other site 314225004585 GtrA-like protein; Region: GtrA; pfam04138 314225004586 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 314225004587 tartrate dehydrogenase; Region: TTC; TIGR02089 314225004588 Recombination protein O N terminal; Region: RecO_N; pfam11967 314225004589 Membrane fusogenic activity; Region: BMFP; pfam04380 314225004590 TspO/MBR family; Region: TspO_MBR; pfam03073 314225004591 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 314225004592 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 314225004593 RNA binding surface [nucleotide binding]; other site 314225004594 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 314225004595 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 314225004596 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 314225004597 homodimer interface [polypeptide binding]; other site 314225004598 substrate-cofactor binding pocket; other site 314225004599 catalytic residue [active] 314225004600 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 314225004601 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 314225004602 active site residue [active] 314225004603 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 314225004604 GST_N family, Omega-like subfamily; composed of uncharacterized proteins with similarity to class Omega GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_Omega_like; cd03060 314225004605 putative GSH binding site (G-site) [chemical binding]; other site 314225004606 active site cysteine [active] 314225004607 putative C-terminal domain interface [polypeptide binding]; other site 314225004608 putative dimer interface [polypeptide binding]; other site 314225004609 C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196 314225004610 putative N-terminal domain interface [polypeptide binding]; other site 314225004611 putative dimer interface [polypeptide binding]; other site 314225004612 putative substrate binding pocket (H-site) [chemical binding]; other site 314225004613 Transcriptional regulator [Transcription]; Region: LysR; COG0583 314225004614 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 314225004615 LysR substrate binding domain; Region: LysR_substrate; pfam03466 314225004616 dimerization interface [polypeptide binding]; other site 314225004617 Pirin-related protein [General function prediction only]; Region: COG1741 314225004618 Pirin; Region: Pirin; pfam02678 314225004619 KduI/IolB family; Region: KduI; cl01508 314225004620 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 314225004621 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 314225004622 EamA-like transporter family; Region: EamA; pfam00892 314225004623 NAD synthetase; Reviewed; Region: nadE; PRK02628 314225004624 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 314225004625 active site 314225004626 catalytic triad [active] 314225004627 multimer interface [polypeptide binding]; other site 314225004628 protein interface 1 [polypeptide binding]; other site 314225004629 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 314225004630 homodimer interface [polypeptide binding]; other site 314225004631 NAD binding pocket [chemical binding]; other site 314225004632 ATP binding pocket [chemical binding]; other site 314225004633 Mg binding site [ion binding]; other site 314225004634 active-site loop [active] 314225004635 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 314225004636 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 314225004637 active site 314225004638 DNA binding site [nucleotide binding] 314225004639 Int/Topo IB signature motif; other site 314225004640 catalytic residues [active] 314225004641 putative S-transferase; Provisional; Region: PRK11752 314225004642 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 314225004643 C-terminal domain interface [polypeptide binding]; other site 314225004644 GSH binding site (G-site) [chemical binding]; other site 314225004645 dimer interface [polypeptide binding]; other site 314225004646 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 314225004647 N-terminal domain interface [polypeptide binding]; other site 314225004648 dimer interface [polypeptide binding]; other site 314225004649 substrate binding pocket (H-site) [chemical binding]; other site 314225004650 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 314225004651 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 314225004652 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 314225004653 catalytic motif [active] 314225004654 Catalytic residue [active] 314225004655 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 314225004656 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 314225004657 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 314225004658 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 314225004659 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 314225004660 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 314225004661 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 314225004662 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 314225004663 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 314225004664 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 314225004665 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 314225004666 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 314225004667 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 314225004668 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 314225004669 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 314225004670 putative FMN binding site [chemical binding]; other site 314225004671 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 314225004672 Glycoprotease family; Region: Peptidase_M22; pfam00814 314225004673 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 314225004674 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 314225004675 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 314225004676 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 314225004677 metal binding site 2 [ion binding]; metal-binding site 314225004678 putative DNA binding helix; other site 314225004679 metal binding site 1 [ion binding]; metal-binding site 314225004680 dimer interface [polypeptide binding]; other site 314225004681 structural Zn2+ binding site [ion binding]; other site 314225004682 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 314225004683 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 314225004684 putative acyl-acceptor binding pocket; other site 314225004685 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 314225004686 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 314225004687 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 314225004688 FeS/SAM binding site; other site 314225004689 TRAM domain; Region: TRAM; pfam01938 314225004690 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 314225004691 PhoH-like protein; Region: PhoH; pfam02562 314225004692 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 314225004693 FOG: CBS domain [General function prediction only]; Region: COG0517 314225004694 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 314225004695 Transporter associated domain; Region: CorC_HlyC; smart01091 314225004696 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 314225004697 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 314225004698 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 314225004699 dimerization interface [polypeptide binding]; other site 314225004700 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 314225004701 nucleophilic elbow; other site 314225004702 catalytic triad; other site 314225004703 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 314225004704 active site 314225004705 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 314225004706 MgtE intracellular N domain; Region: MgtE_N; smart00924 314225004707 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 314225004708 Divalent cation transporter; Region: MgtE; pfam01769 314225004709 Putative cyclase; Region: Cyclase; pfam04199 314225004710 Protein of unknown function (DUF1489); Region: DUF1489; pfam07370 314225004711 short chain dehydrogenase; Provisional; Region: PRK06181 314225004712 classical (c) SDRs; Region: SDR_c; cd05233 314225004713 NAD(P) binding site [chemical binding]; other site 314225004714 active site 314225004715 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 314225004716 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 314225004717 catalytic residues [active] 314225004718 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 314225004719 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 314225004720 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 314225004721 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 314225004722 putative NADH binding site [chemical binding]; other site 314225004723 putative active site [active] 314225004724 nudix motif; other site 314225004725 putative metal binding site [ion binding]; other site 314225004726 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 314225004727 Beta-lactamase; Region: Beta-lactamase; pfam00144 314225004728 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 314225004729 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 314225004730 minor groove reading motif; other site 314225004731 helix-hairpin-helix signature motif; other site 314225004732 substrate binding pocket [chemical binding]; other site 314225004733 active site 314225004734 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 314225004735 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 314225004736 DNA binding and oxoG recognition site [nucleotide binding] 314225004737 Protein of unknown function (DUF721); Region: DUF721; pfam05258 314225004738 Thioredoxin; Region: Thioredoxin_4; cl17273 314225004739 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 314225004740 Thioredoxin; Region: Thioredoxin_4; pfam13462 314225004741 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 314225004742 AAA domain; Region: AAA_23; pfam13476 314225004743 Walker A/P-loop; other site 314225004744 ATP binding site [chemical binding]; other site 314225004745 Q-loop/lid; other site 314225004746 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 314225004747 Q-loop/lid; other site 314225004748 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 314225004749 ABC transporter signature motif; other site 314225004750 ABC transporter signature motif; other site 314225004751 Walker B; other site 314225004752 Walker B; other site 314225004753 D-loop; other site 314225004754 D-loop; other site 314225004755 H-loop/switch region; other site 314225004756 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 314225004757 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 314225004758 DNA binding residues [nucleotide binding] 314225004759 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 314225004760 IHF dimer interface [polypeptide binding]; other site 314225004761 IHF - DNA interface [nucleotide binding]; other site 314225004762 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 314225004763 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 314225004764 dimer interface [polypeptide binding]; other site 314225004765 active site 314225004766 CoA binding pocket [chemical binding]; other site 314225004767 putative phosphate acyltransferase; Provisional; Region: PRK05331 314225004768 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 314225004769 MAPEG family; Region: MAPEG; pfam01124 314225004770 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 314225004771 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 314225004772 Predicted transcriptional regulator [Transcription]; Region: COG2932 314225004773 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 314225004774 Catalytic site [active] 314225004775 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 314225004776 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 314225004777 NAD binding site [chemical binding]; other site 314225004778 ligand binding site [chemical binding]; other site 314225004779 catalytic site [active] 314225004780 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 314225004781 RES domain; Region: RES; pfam08808 314225004782 cysteinyl-tRNA synthetase; Provisional; Region: cysS; PRK14536 314225004783 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 314225004784 active site 314225004785 HIGH motif; other site 314225004786 nucleotide binding site [chemical binding]; other site 314225004787 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 314225004788 active site 314225004789 KMSKS motif; other site 314225004790 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 314225004791 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 314225004792 putative FMN binding site [chemical binding]; other site 314225004793 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 314225004794 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 314225004795 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 314225004796 metal ion-dependent adhesion site (MIDAS); other site 314225004797 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 314225004798 active site 314225004799 intersubunit interactions; other site 314225004800 catalytic residue [active] 314225004801 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 314225004802 primosome assembly protein PriA; Validated; Region: PRK05580 314225004803 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 314225004804 ATP binding site [chemical binding]; other site 314225004805 putative Mg++ binding site [ion binding]; other site 314225004806 helicase superfamily c-terminal domain; Region: HELICc; smart00490 314225004807 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 314225004808 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 314225004809 putative C-terminal domain interface [polypeptide binding]; other site 314225004810 putative GSH binding site (G-site) [chemical binding]; other site 314225004811 putative dimer interface [polypeptide binding]; other site 314225004812 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 314225004813 N-terminal domain interface [polypeptide binding]; other site 314225004814 dimer interface [polypeptide binding]; other site 314225004815 substrate binding pocket (H-site) [chemical binding]; other site 314225004816 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 314225004817 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 314225004818 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 314225004819 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 314225004820 NAD(P) binding site [chemical binding]; other site 314225004821 catalytic residues [active] 314225004822 SnoaL-like domain; Region: SnoaL_2; pfam12680 314225004823 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 314225004824 homotrimer interaction site [polypeptide binding]; other site 314225004825 putative active site [active] 314225004826 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 314225004827 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 314225004828 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 314225004829 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 314225004830 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 314225004831 DNA binding site [nucleotide binding] 314225004832 active site 314225004833 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 314225004834 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 314225004835 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 314225004836 active site 314225004837 iron coordination sites [ion binding]; other site 314225004838 substrate binding pocket [chemical binding]; other site 314225004839 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 314225004840 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 314225004841 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 314225004842 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 314225004843 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 314225004844 beta subunit interaction interface [polypeptide binding]; other site 314225004845 Walker A motif; other site 314225004846 ATP binding site [chemical binding]; other site 314225004847 Walker B motif; other site 314225004848 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 314225004849 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 314225004850 core domain interface [polypeptide binding]; other site 314225004851 delta subunit interface [polypeptide binding]; other site 314225004852 epsilon subunit interface [polypeptide binding]; other site 314225004853 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 314225004854 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 314225004855 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 314225004856 alpha subunit interaction interface [polypeptide binding]; other site 314225004857 Walker A motif; other site 314225004858 ATP binding site [chemical binding]; other site 314225004859 Walker B motif; other site 314225004860 inhibitor binding site; inhibition site 314225004861 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 314225004862 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 314225004863 gamma subunit interface [polypeptide binding]; other site 314225004864 LBP interface [polypeptide binding]; other site 314225004865 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 314225004866 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 314225004867 SOUL heme-binding protein; Region: SOUL; pfam04832 314225004868 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 314225004869 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 314225004870 Substrate binding site; other site 314225004871 Mg++ binding site; other site 314225004872 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 314225004873 active site 314225004874 substrate binding site [chemical binding]; other site 314225004875 CoA binding site [chemical binding]; other site 314225004876 phosphoglycolate phosphatase; Provisional; Region: PRK13222 314225004877 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 314225004878 motif II; other site 314225004879 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 314225004880 short chain dehydrogenase; Provisional; Region: PRK07791 314225004881 NAD binding site [chemical binding]; other site 314225004882 homodimer interface [polypeptide binding]; other site 314225004883 active site 314225004884 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 314225004885 serine O-acetyltransferase; Region: cysE; TIGR01172 314225004886 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 314225004887 trimer interface [polypeptide binding]; other site 314225004888 active site 314225004889 substrate binding site [chemical binding]; other site 314225004890 CoA binding site [chemical binding]; other site 314225004891 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 314225004892 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 314225004893 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 314225004894 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 314225004895 dimerization interface [polypeptide binding]; other site 314225004896 putative ATP binding site [chemical binding]; other site 314225004897 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 314225004898 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 314225004899 active site 314225004900 substrate binding site [chemical binding]; other site 314225004901 cosubstrate binding site; other site 314225004902 catalytic site [active] 314225004903 Protein of unknown function (DUF419); Region: DUF419; pfam04237 314225004904 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 314225004905 active site 314225004906 multimer interface [polypeptide binding]; other site 314225004907 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 314225004908 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 314225004909 multifunctional aminopeptidase A; Provisional; Region: PRK00913 314225004910 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 314225004911 interface (dimer of trimers) [polypeptide binding]; other site 314225004912 Substrate-binding/catalytic site; other site 314225004913 Zn-binding sites [ion binding]; other site 314225004914 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 314225004915 Organic solvent tolerance protein; Region: OstA_C; pfam04453 314225004916 SurA N-terminal domain; Region: SurA_N; pfam09312 314225004917 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 314225004918 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 314225004919 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 314225004920 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 314225004921 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 314225004922 S-adenosylmethionine binding site [chemical binding]; other site 314225004923 malate synthase G; Provisional; Region: PRK02999 314225004924 active site 314225004925 hypothetical protein; Provisional; Region: PRK07338 314225004926 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 314225004927 metal binding site [ion binding]; metal-binding site 314225004928 dimer interface [polypeptide binding]; other site 314225004929 Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958 314225004930 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 314225004931 succinylarginine dihydrolase; Provisional; Region: PRK13281 314225004932 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 314225004933 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 314225004934 LemA family; Region: LemA; cl00742 314225004935 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 314225004936 Repair protein; Region: Repair_PSII; pfam04536 314225004937 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 314225004938 Repair protein; Region: Repair_PSII; pfam04536 314225004939 Repair protein; Region: Repair_PSII; cl01535 314225004940 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 314225004941 dimer interface [polypeptide binding]; other site 314225004942 active site 314225004943 ADP-ribose binding site [chemical binding]; other site 314225004944 nudix motif; other site 314225004945 metal binding site [ion binding]; metal-binding site 314225004946 short chain dehydrogenase; Validated; Region: PRK07069 314225004947 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 314225004948 NAD(P) binding site [chemical binding]; other site 314225004949 active site 314225004950 PspC domain; Region: PspC; pfam04024 314225004951 recombination protein F; Reviewed; Region: recF; PRK00064 314225004952 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 314225004953 Walker A/P-loop; other site 314225004954 ATP binding site [chemical binding]; other site 314225004955 Q-loop/lid; other site 314225004956 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 314225004957 ABC transporter signature motif; other site 314225004958 Walker B; other site 314225004959 D-loop; other site 314225004960 H-loop/switch region; other site 314225004961 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 314225004962 active site 314225004963 catalytic triad [active] 314225004964 oxyanion hole [active] 314225004965 switch loop; other site 314225004966 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 314225004967 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 314225004968 Walker A/P-loop; other site 314225004969 ATP binding site [chemical binding]; other site 314225004970 Q-loop/lid; other site 314225004971 ABC transporter signature motif; other site 314225004972 Walker B; other site 314225004973 D-loop; other site 314225004974 H-loop/switch region; other site 314225004975 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 314225004976 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 314225004977 Protein of unknown function (DUF805); Region: DUF805; pfam05656 314225004978 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 314225004979 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 314225004980 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 314225004981 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 314225004982 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 314225004983 G1 box; other site 314225004984 putative GEF interaction site [polypeptide binding]; other site 314225004985 GTP/Mg2+ binding site [chemical binding]; other site 314225004986 Switch I region; other site 314225004987 G2 box; other site 314225004988 G3 box; other site 314225004989 Switch II region; other site 314225004990 G4 box; other site 314225004991 G5 box; other site 314225004992 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 314225004993 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 314225004994 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 314225004995 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 314225004996 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 314225004997 Walker A/P-loop; other site 314225004998 ATP binding site [chemical binding]; other site 314225004999 Q-loop/lid; other site 314225005000 ABC transporter signature motif; other site 314225005001 Walker B; other site 314225005002 D-loop; other site 314225005003 H-loop/switch region; other site 314225005004 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 314225005005 ATP-grasp domain; Region: ATP-grasp_4; cl17255 314225005006 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 314225005007 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 314225005008 Na binding site [ion binding]; other site 314225005009 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 314225005010 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 314225005011 active site 314225005012 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 314225005013 classical (c) SDRs; Region: SDR_c; cd05233 314225005014 NAD(P) binding site [chemical binding]; other site 314225005015 active site 314225005016 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 314225005017 response regulator FixJ; Provisional; Region: fixJ; PRK09390 314225005018 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 314225005019 active site 314225005020 dimerization interface [polypeptide binding]; other site 314225005021 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 314225005022 DNA binding residues [nucleotide binding] 314225005023 dimerization interface [polypeptide binding]; other site 314225005024 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 314225005025 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 314225005026 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 314225005027 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 314225005028 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 314225005029 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 314225005030 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 314225005031 Uncharacterized conserved protein [Function unknown]; Region: COG2308 314225005032 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 314225005033 PGAP1-like protein; Region: PGAP1; pfam07819 314225005034 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 314225005035 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 314225005036 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 314225005037 excinuclease ABC subunit B; Provisional; Region: PRK05298 314225005038 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 314225005039 ATP binding site [chemical binding]; other site 314225005040 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 314225005041 nucleotide binding region [chemical binding]; other site 314225005042 ATP-binding site [chemical binding]; other site 314225005043 Ultra-violet resistance protein B; Region: UvrB; pfam12344 314225005044 UvrB/uvrC motif; Region: UVR; pfam02151 314225005045 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 314225005046 HTH-like domain; Region: HTH_21; pfam13276 314225005047 Integrase core domain; Region: rve; pfam00665 314225005048 Integrase core domain; Region: rve_3; pfam13683 314225005049 Transposase; Region: HTH_Tnp_1; pfam01527 314225005050 YcfA-like protein; Region: YcfA; pfam07927 314225005051 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 314225005052 serine/threonine kinase US3; Provisional; Region: PHA03212 314225005053 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 314225005054 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 314225005055 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 314225005056 DsbD alpha interface [polypeptide binding]; other site 314225005057 catalytic residues [active] 314225005058 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 314225005059 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 314225005060 Mitochondrial inner membrane protein; Region: Mitofilin; pfam09731 314225005061 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 314225005062 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 314225005063 active site 314225005064 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 314225005065 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 314225005066 domain interfaces; other site 314225005067 active site 314225005068 UGMP family protein; Validated; Region: PRK09604 314225005069 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 314225005070 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 314225005071 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 314225005072 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 314225005073 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 314225005074 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 314225005075 von Willebrand factor; Region: vWF_A; pfam12450 314225005076 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 314225005077 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 314225005078 metal ion-dependent adhesion site (MIDAS); other site 314225005079 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 314225005080 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 314225005081 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 314225005082 ligand binding site [chemical binding]; other site 314225005083 Uncharacterized conserved protein [Function unknown]; Region: COG3743 314225005084 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 314225005085 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 314225005086 active site 314225005087 phosphorylation site [posttranslational modification] 314225005088 intermolecular recognition site; other site 314225005089 dimerization interface [polypeptide binding]; other site 314225005090 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 314225005091 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 314225005092 FAD binding site [chemical binding]; other site 314225005093 substrate binding pocket [chemical binding]; other site 314225005094 catalytic base [active] 314225005095 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 314225005096 maleylacetoacetate isomerase; Region: maiA; TIGR01262 314225005097 C-terminal domain interface [polypeptide binding]; other site 314225005098 GSH binding site (G-site) [chemical binding]; other site 314225005099 putative dimer interface [polypeptide binding]; other site 314225005100 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 314225005101 dimer interface [polypeptide binding]; other site 314225005102 N-terminal domain interface [polypeptide binding]; other site 314225005103 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 314225005104 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 314225005105 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 314225005106 Protein of unknown function (DUF421); Region: DUF421; pfam04239 314225005107 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 314225005108 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 314225005109 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 314225005110 NAD(P) binding site [chemical binding]; other site 314225005111 catalytic residues [active] 314225005112 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 314225005113 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 314225005114 GTP binding site; other site 314225005115 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 314225005116 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 314225005117 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 314225005118 active site 314225005119 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 314225005120 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 314225005121 active site 314225005122 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 314225005123 Predicted membrane protein [Function unknown]; Region: COG3817 314225005124 Protein of unknown function (DUF979); Region: DUF979; pfam06166 314225005125 Protein of unknown function (DUF969); Region: DUF969; pfam06149 314225005126 5-oxoprolinase; Region: PLN02666 314225005127 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 314225005128 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 314225005129 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 314225005130 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 314225005131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 314225005132 active site 314225005133 phosphorylation site [posttranslational modification] 314225005134 intermolecular recognition site; other site 314225005135 dimerization interface [polypeptide binding]; other site 314225005136 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 314225005137 DNA binding residues [nucleotide binding] 314225005138 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 314225005139 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 314225005140 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 314225005141 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 314225005142 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 314225005143 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 314225005144 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 314225005145 Phage protein D [General function prediction only]; Region: COG3500 314225005146 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 314225005147 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 314225005148 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 314225005149 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 314225005150 phage tail protein domain; Region: tail_TIGR02242 314225005151 IPT/TIG domain; Region: TIG; pfam01833 314225005152 large tegument protein UL36; Provisional; Region: PHA03247 314225005153 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 314225005154 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 314225005155 Walker A motif; other site 314225005156 ATP binding site [chemical binding]; other site 314225005157 Walker B motif; other site 314225005158 arginine finger; other site 314225005159 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 314225005160 Phage-related protein [Function unknown]; Region: COG5412 314225005161 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 314225005162 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 314225005163 HIGH motif; other site 314225005164 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 314225005165 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 314225005166 active site 314225005167 KMSKS motif; other site 314225005168 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 314225005169 tRNA binding surface [nucleotide binding]; other site 314225005170 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 314225005171 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 314225005172 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 314225005173 active site 314225005174 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 314225005175 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 314225005176 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 314225005177 Zn2+ binding site [ion binding]; other site 314225005178 Mg2+ binding site [ion binding]; other site 314225005179 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 314225005180 synthetase active site [active] 314225005181 NTP binding site [chemical binding]; other site 314225005182 metal binding site [ion binding]; metal-binding site 314225005183 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 314225005184 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 314225005185 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 314225005186 active site 314225005187 nucleophile elbow; other site 314225005188 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 314225005189 iron-sulfur cluster [ion binding]; other site 314225005190 [2Fe-2S] cluster binding site [ion binding]; other site 314225005191 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 314225005192 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 314225005193 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 314225005194 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 314225005195 putative active site [active] 314225005196 putative metal binding site [ion binding]; other site 314225005197 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 314225005198 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 314225005199 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 314225005200 Protein of unknown function, DUF547; Region: DUF547; pfam04784 314225005201 Protein of unknown function, DUF547; Region: DUF547; pfam04784 314225005202 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 314225005203 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 314225005204 transmembrane helices; other site 314225005205 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 314225005206 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 314225005207 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 314225005208 methionine gamma-lyase; Validated; Region: PRK07049 314225005209 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 314225005210 homodimer interface [polypeptide binding]; other site 314225005211 substrate-cofactor binding pocket; other site 314225005212 pyridoxal 5'-phosphate binding site [chemical binding]; other site 314225005213 catalytic residue [active] 314225005214 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 314225005215 ATP-grasp domain; Region: ATP-grasp; pfam02222 314225005216 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06077 314225005217 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 314225005218 NAD(P) binding site [chemical binding]; other site 314225005219 active site 314225005220 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 314225005221 HSP70 interaction site [polypeptide binding]; other site 314225005222 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 314225005223 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 314225005224 ligand binding site [chemical binding]; other site 314225005225 translocation protein TolB; Provisional; Region: tolB; PRK05137 314225005226 TolB amino-terminal domain; Region: TolB_N; pfam04052 314225005227 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 314225005228 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 314225005229 Gram-negative bacterial tonB protein; Region: TonB; cl10048 314225005230 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 314225005231 TolR protein; Region: tolR; TIGR02801 314225005232 TolQ protein; Region: tolQ; TIGR02796 314225005233 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 314225005234 active site 314225005235 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 314225005236 nucleotide binding site/active site [active] 314225005237 HIT family signature motif; other site 314225005238 catalytic residue [active] 314225005239 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 314225005240 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 314225005241 metal binding site [ion binding]; metal-binding site 314225005242 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 314225005243 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 314225005244 substrate binding site [chemical binding]; other site 314225005245 glutamase interaction surface [polypeptide binding]; other site 314225005246 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 314225005247 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 314225005248 catalytic residues [active] 314225005249 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 314225005250 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 314225005251 putative active site [active] 314225005252 oxyanion strand; other site 314225005253 catalytic triad [active] 314225005254 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 314225005255 putative active site pocket [active] 314225005256 4-fold oligomerization interface [polypeptide binding]; other site 314225005257 metal binding residues [ion binding]; metal-binding site 314225005258 3-fold/trimer interface [polypeptide binding]; other site 314225005259 Stringent starvation protein B; Region: SspB; pfam04386 314225005260 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 314225005261 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 314225005262 catalytic site [active] 314225005263 G-X2-G-X-G-K; other site 314225005264 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 314225005265 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 314225005266 putative di-iron ligands [ion binding]; other site 314225005267 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 314225005268 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 314225005269 NAD(P) binding site [chemical binding]; other site 314225005270 active site 314225005271 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 314225005272 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 314225005273 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 314225005274 active site 314225005275 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 314225005276 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 314225005277 active site 314225005278 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 314225005279 classical (c) SDRs; Region: SDR_c; cd05233 314225005280 NAD(P) binding site [chemical binding]; other site 314225005281 active site 314225005282 MFS/sugar transport protein; Region: MFS_2; pfam13347 314225005283 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 314225005284 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 314225005285 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 314225005286 active site 314225005287 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 314225005288 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 314225005289 NAD binding site [chemical binding]; other site 314225005290 catalytic Zn binding site [ion binding]; other site 314225005291 substrate binding site [chemical binding]; other site 314225005292 structural Zn binding site [ion binding]; other site 314225005293 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 314225005294 putative active site [active] 314225005295 putative substrate binding site [chemical binding]; other site 314225005296 ATP binding site [chemical binding]; other site 314225005297 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 314225005298 catalytic triad [active] 314225005299 putative active site [active] 314225005300 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 314225005301 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 314225005302 trimer interface [polypeptide binding]; other site 314225005303 active site 314225005304 substrate binding site [chemical binding]; other site 314225005305 CoA binding site [chemical binding]; other site 314225005306 Protein of unknwon function (DUF3008); Region: DUF3008; pfam11450 314225005307 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 314225005308 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 314225005309 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 314225005310 active site 314225005311 dimer interface [polypeptide binding]; other site 314225005312 Predicted membrane protein [Function unknown]; Region: COG4270 314225005313 SWIB/MDM2 domain; Region: SWIB; pfam02201 314225005314 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 314225005315 substrate binding site [chemical binding]; other site 314225005316 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 314225005317 protein binding site [polypeptide binding]; other site 314225005318 C-terminal processing peptidase-like; serine protease family S41; Region: Peptidase_S41_CPP_like; cd07561 314225005319 Catalytic dyad [active] 314225005320 Protein of unknown function (DUF962); Region: DUF962; pfam06127 314225005321 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 314225005322 Fasciclin domain; Region: Fasciclin; pfam02469 314225005323 Domain of unknown function (DUF427); Region: DUF427; pfam04248 314225005324 Predicted membrane protein [Function unknown]; Region: COG3650 314225005325 Uncharacterized conserved protein [Function unknown]; Region: COG3791 314225005326 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 314225005327 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 314225005328 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 314225005329 EthD domain; Region: EthD; pfam07110 314225005330 FeoC like transcriptional regulator; Region: FeoC; cl17677 314225005331 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 314225005332 30S subunit binding site; other site 314225005333 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 314225005334 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 314225005335 DNA-binding site [nucleotide binding]; DNA binding site 314225005336 RNA-binding motif; other site 314225005337 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 314225005338 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 314225005339 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 314225005340 ThiC-associated domain; Region: ThiC-associated; pfam13667 314225005341 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 314225005342 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 314225005343 EF-hand domain pair; Region: EF_hand_5; pfam13499 314225005344 Ca2+ binding site [ion binding]; other site 314225005345 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 314225005346 Ca2+ binding site [ion binding]; other site 314225005347 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 314225005348 Cytochrome P450; Region: p450; cl12078 314225005349 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 314225005350 Glutathione S-transferase, C-terminal domain; Region: GST_C_2; pfam13410 314225005351 N-terminal domain interface [polypeptide binding]; other site 314225005352 Nitronate monooxygenase; Region: NMO; pfam03060 314225005353 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 314225005354 FMN binding site [chemical binding]; other site 314225005355 substrate binding site [chemical binding]; other site 314225005356 putative catalytic residue [active] 314225005357 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 314225005358 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 314225005359 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 314225005360 CoenzymeA binding site [chemical binding]; other site 314225005361 subunit interaction site [polypeptide binding]; other site 314225005362 PHB binding site; other site 314225005363 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 314225005364 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 314225005365 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 314225005366 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 314225005367 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 314225005368 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 314225005369 active site 314225005370 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 314225005371 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 314225005372 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 314225005373 Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834 314225005374 lycopene cyclase; Region: lycopene_cycl; TIGR01789 314225005375 phytoene desaturase; Region: crtI_fam; TIGR02734 314225005376 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 314225005377 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 314225005378 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 314225005379 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 314225005380 active site lid residues [active] 314225005381 substrate binding pocket [chemical binding]; other site 314225005382 catalytic residues [active] 314225005383 substrate-Mg2+ binding site; other site 314225005384 aspartate-rich region 1; other site 314225005385 aspartate-rich region 2; other site 314225005386 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 314225005387 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 314225005388 ATP-grasp domain; Region: ATP-grasp_4; cl17255 314225005389 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 314225005390 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 314225005391 carboxyltransferase (CT) interaction site; other site 314225005392 biotinylation site [posttranslational modification]; other site 314225005393 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 314225005394 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 314225005395 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 314225005396 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 314225005397 putative substrate translocation pore; other site 314225005398 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 314225005399 active site 314225005400 DNA polymerase IV; Validated; Region: PRK02406 314225005401 DNA binding site [nucleotide binding] 314225005402 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 314225005403 nudix motif; other site 314225005404 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 314225005405 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 314225005406 putative active site [active] 314225005407 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 314225005408 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 314225005409 dimerization interface [polypeptide binding]; other site 314225005410 DPS ferroxidase diiron center [ion binding]; other site 314225005411 ion pore; other site 314225005412 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 314225005413 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 314225005414 NAD(P) binding site [chemical binding]; other site 314225005415 active site 314225005416 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 314225005417 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 314225005418 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 314225005419 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 314225005420 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 314225005421 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 314225005422 catalytic tetrad [active] 314225005423 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 314225005424 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 314225005425 DNA binding residues [nucleotide binding] 314225005426 dimer interface [polypeptide binding]; other site 314225005427 putative metal binding site [ion binding]; other site 314225005428 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 314225005429 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 314225005430 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 314225005431 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 314225005432 integrase; Provisional; Region: PRK09692 314225005433 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 314225005434 active site 314225005435 Int/Topo IB signature motif; other site 314225005436 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 314225005437 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 314225005438 tetrameric interface [polypeptide binding]; other site 314225005439 NAD binding site [chemical binding]; other site 314225005440 catalytic residues [active] 314225005441 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 314225005442 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 314225005443 homotrimer interaction site [polypeptide binding]; other site 314225005444 putative active site [active] 314225005445 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 314225005446 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 314225005447 active site 314225005448 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 314225005449 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 314225005450 substrate binding site [chemical binding]; other site 314225005451 oxyanion hole (OAH) forming residues; other site 314225005452 trimer interface [polypeptide binding]; other site 314225005453 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 314225005454 enoyl-CoA hydratase; Provisional; Region: PRK05862 314225005455 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 314225005456 substrate binding site [chemical binding]; other site 314225005457 oxyanion hole (OAH) forming residues; other site 314225005458 trimer interface [polypeptide binding]; other site 314225005459 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 314225005460 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 314225005461 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 314225005462 active site 314225005463 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 314225005464 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 314225005465 glycine dehydrogenase subunit 2; Validated; Region: PRK04366 314225005466 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 314225005467 catalytic residue [active] 314225005468 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 314225005469 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 314225005470 tetramer interface [polypeptide binding]; other site 314225005471 pyridoxal 5'-phosphate binding site [chemical binding]; other site 314225005472 catalytic residue [active] 314225005473 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 314225005474 lipoyl attachment site [posttranslational modification]; other site 314225005475 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 314225005476 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 314225005477 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 314225005478 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 314225005479 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 314225005480 substrate binding pocket [chemical binding]; other site 314225005481 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 314225005482 B12 binding site [chemical binding]; other site 314225005483 cobalt ligand [ion binding]; other site 314225005484 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 314225005485 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 314225005486 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 314225005487 Coenzyme A binding pocket [chemical binding]; other site 314225005488 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 314225005489 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 314225005490 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 314225005491 FAD binding site [chemical binding]; other site 314225005492 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 314225005493 putative DNA binding site [nucleotide binding]; other site 314225005494 dimerization interface [polypeptide binding]; other site 314225005495 putative Zn2+ binding site [ion binding]; other site 314225005496 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 314225005497 S-adenosylmethionine binding site [chemical binding]; other site 314225005498 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 314225005499 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 314225005500 active site 314225005501 catalytic tetrad [active] 314225005502 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 314225005503 Domain of unknown function (DUF4402); Region: DUF4402; pfam14352 314225005504 Domain of unknown function (DUF4402); Region: DUF4402; pfam14352 314225005505 Domain of unknown function (DUF4402); Region: DUF4402; pfam14352 314225005506 Domain of unknown function (DUF4402); Region: DUF4402; pfam14352 314225005507 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 314225005508 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 314225005509 active site 2 [active] 314225005510 active site 1 [active] 314225005511 enoyl-CoA hydratase; Provisional; Region: PRK07509 314225005512 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 314225005513 substrate binding site [chemical binding]; other site 314225005514 oxyanion hole (OAH) forming residues; other site 314225005515 trimer interface [polypeptide binding]; other site 314225005516 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 314225005517 MPN+ (JAMM) motif; other site 314225005518 Zinc-binding site [ion binding]; other site 314225005519 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 314225005520 DNA binding residues [nucleotide binding] 314225005521 dimerization interface [polypeptide binding]; other site 314225005522 aminotransferase; Validated; Region: PRK09148 314225005523 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 314225005524 pyridoxal 5'-phosphate binding site [chemical binding]; other site 314225005525 homodimer interface [polypeptide binding]; other site 314225005526 catalytic residue [active] 314225005527 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 314225005528 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 314225005529 Phasin protein; Region: Phasin_2; pfam09361 314225005530 Uncharacterized conserved protein [Function unknown]; Region: COG2127 314225005531 Predicted permeases [General function prediction only]; Region: COG0795 314225005532 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 314225005533 Predicted permeases [General function prediction only]; Region: COG0795 314225005534 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 314225005535 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 314225005536 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 314225005537 Coenzyme A binding pocket [chemical binding]; other site 314225005538 Fatty acid desaturase; Region: FA_desaturase; pfam00487 314225005539 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 314225005540 two-component response regulator; Provisional; Region: PRK09191 314225005541 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 314225005542 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 314225005543 active site 314225005544 phosphorylation site [posttranslational modification] 314225005545 intermolecular recognition site; other site 314225005546 dimerization interface [polypeptide binding]; other site 314225005547 CHASE domain; Region: CHASE; pfam03924 314225005548 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 314225005549 HWE histidine kinase; Region: HWE_HK; pfam07536 314225005550 RNA polymerase sigma factor; Provisional; Region: PRK12547 314225005551 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 314225005552 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 314225005553 DNA binding residues [nucleotide binding] 314225005554 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 314225005555 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 314225005556 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 314225005557 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 314225005558 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 314225005559 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 314225005560 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 314225005561 active site 314225005562 substrate binding site [chemical binding]; other site 314225005563 metal binding site [ion binding]; metal-binding site 314225005564 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 314225005565 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 314225005566 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 314225005567 dimer interface [polypeptide binding]; other site 314225005568 substrate binding site [chemical binding]; other site 314225005569 ATP binding site [chemical binding]; other site 314225005570 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 314225005571 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 314225005572 exopolyphosphatase; Region: exo_poly_only; TIGR03706 314225005573 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 314225005574 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 314225005575 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 314225005576 Cytochrome c2 [Energy production and conversion]; Region: COG3474 314225005577 prephenate dehydratase; Provisional; Region: PRK11899 314225005578 Prephenate dehydratase; Region: PDT; pfam00800 314225005579 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 314225005580 putative L-Phe binding site [chemical binding]; other site 314225005581 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 314225005582 MoxR-like ATPases [General function prediction only]; Region: COG0714 314225005583 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 314225005584 Walker A motif; other site 314225005585 ATP binding site [chemical binding]; other site 314225005586 Walker B motif; other site 314225005587 arginine finger; other site 314225005588 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 314225005589 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 314225005590 metal ion-dependent adhesion site (MIDAS); other site 314225005591 Integral membrane protein DUF95; Region: DUF95; pfam01944 314225005592 RDD family; Region: RDD; pfam06271 314225005593 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 314225005594 Fatty acid desaturase; Region: FA_desaturase; pfam00487 314225005595 putative di-iron ligands [ion binding]; other site 314225005596 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 314225005597 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 314225005598 catalytic nucleophile [active] 314225005599 Conserved TM helix; Region: TM_helix; pfam05552 314225005600 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 314225005601 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 314225005602 Coenzyme A binding pocket [chemical binding]; other site 314225005603 oxidoreductase; Provisional; Region: PRK06196 314225005604 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 314225005605 putative NAD(P) binding site [chemical binding]; other site 314225005606 active site 314225005607 RNA polymerase sigma factor; Provisional; Region: PRK12539 314225005608 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 314225005609 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 314225005610 DNA binding residues [nucleotide binding] 314225005611 Protein of unknown function (DUF1109); Region: DUF1109; pfam06532 314225005612 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 314225005613 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 314225005614 Cl binding site [ion binding]; other site 314225005615 oligomer interface [polypeptide binding]; other site 314225005616 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 314225005617 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 314225005618 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 314225005619 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 314225005620 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 314225005621 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 314225005622 putative active site [active] 314225005623 Zn binding site [ion binding]; other site 314225005624 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 314225005625 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 314225005626 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 314225005627 aconitate hydratase; Validated; Region: PRK09277 314225005628 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 314225005629 substrate binding site [chemical binding]; other site 314225005630 ligand binding site [chemical binding]; other site 314225005631 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 314225005632 substrate binding site [chemical binding]; other site 314225005633 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 314225005634 active site residue [active] 314225005635 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 314225005636 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 314225005637 Walker A motif; other site 314225005638 ATP binding site [chemical binding]; other site 314225005639 Walker B motif; other site 314225005640 arginine finger; other site 314225005641 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 314225005642 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 314225005643 GIY-YIG motif/motif A; other site 314225005644 putative active site [active] 314225005645 putative metal binding site [ion binding]; other site 314225005646 DsrE/DsrF-like family; Region: DrsE; pfam02635 314225005647 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 314225005648 RuvA N terminal domain; Region: RuvA_N; pfam01330 314225005649 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 314225005650 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 314225005651 Tetramer interface [polypeptide binding]; other site 314225005652 active site 314225005653 FMN-binding site [chemical binding]; other site 314225005654 peroxiredoxin; Region: AhpC; TIGR03137 314225005655 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 314225005656 dimer interface [polypeptide binding]; other site 314225005657 decamer (pentamer of dimers) interface [polypeptide binding]; other site 314225005658 catalytic triad [active] 314225005659 peroxidatic and resolving cysteines [active] 314225005660 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 314225005661 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 314225005662 catalytic residue [active] 314225005663 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 314225005664 catalytic residues [active] 314225005665 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 314225005666 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 314225005667 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 314225005668 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 314225005669 heme binding site [chemical binding]; other site 314225005670 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 314225005671 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 314225005672 LytTr DNA-binding domain; Region: LytTR; pfam04397 314225005673 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 314225005674 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 314225005675 Smr domain; Region: Smr; pfam01713 314225005676 MltA specific insert domain; Region: MltA; smart00925 314225005677 3D domain; Region: 3D; pfam06725 314225005678 Tim44-like domain; Region: Tim44; pfam04280 314225005679 Preprotein translocase subunit SecB; Region: SecB; pfam02556 314225005680 SecA binding site; other site 314225005681 Preprotein binding site; other site 314225005682 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 314225005683 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 314225005684 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 314225005685 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 314225005686 active site 314225005687 HIGH motif; other site 314225005688 dimer interface [polypeptide binding]; other site 314225005689 KMSKS motif; other site 314225005690 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 314225005691 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 314225005692 trimer interface [polypeptide binding]; other site 314225005693 active site 314225005694 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 314225005695 Flavoprotein; Region: Flavoprotein; pfam02441 314225005696 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 314225005697 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 314225005698 ABC1 family; Region: ABC1; pfam03109 314225005699 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 314225005700 active site 314225005701 ATP binding site [chemical binding]; other site 314225005702 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 314225005703 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 314225005704 S-adenosylmethionine binding site [chemical binding]; other site 314225005705 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 314225005706 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 314225005707 DNA binding site [nucleotide binding] 314225005708 catalytic residue [active] 314225005709 H2TH interface [polypeptide binding]; other site 314225005710 putative catalytic residues [active] 314225005711 turnover-facilitating residue; other site 314225005712 intercalation triad [nucleotide binding]; other site 314225005713 8OG recognition residue [nucleotide binding]; other site 314225005714 putative reading head residues; other site 314225005715 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 314225005716 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 314225005717 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 314225005718 DnaA N-terminal domain; Region: DnaA_N; pfam11638 314225005719 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 314225005720 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 314225005721 Walker A motif; other site 314225005722 ATP binding site [chemical binding]; other site 314225005723 Walker B motif; other site 314225005724 arginine finger; other site 314225005725 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 314225005726 DnaA box-binding interface [nucleotide binding]; other site 314225005727 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 314225005728 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 314225005729 ATP binding site [chemical binding]; other site 314225005730 substrate interface [chemical binding]; other site 314225005731 NAD-dependent deacetylase; Provisional; Region: PRK00481 314225005732 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 314225005733 NAD+ binding site [chemical binding]; other site 314225005734 substrate binding site [chemical binding]; other site 314225005735 Zn binding site [ion binding]; other site 314225005736 dihydrodipicolinate reductase; Provisional; Region: PRK00048 314225005737 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 314225005738 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 314225005739 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 314225005740 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 314225005741 minor groove reading motif; other site 314225005742 helix-hairpin-helix signature motif; other site 314225005743 substrate binding pocket [chemical binding]; other site 314225005744 active site 314225005745 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 314225005746 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 314225005747 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 314225005748 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 314225005749 metal binding site [ion binding]; metal-binding site 314225005750 dimer interface [polypeptide binding]; other site 314225005751 Cupin domain; Region: Cupin_2; cl17218 314225005752 S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010 314225005753 active site 314225005754 Zn binding site [ion binding]; other site 314225005755 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 314225005756 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 314225005757 putative C-terminal domain interface [polypeptide binding]; other site 314225005758 putative GSH binding site (G-site) [chemical binding]; other site 314225005759 putative dimer interface [polypeptide binding]; other site 314225005760 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 314225005761 putative N-terminal domain interface [polypeptide binding]; other site 314225005762 putative dimer interface [polypeptide binding]; other site 314225005763 putative substrate binding pocket (H-site) [chemical binding]; other site 314225005764 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 314225005765 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 314225005766 substrate binding pocket [chemical binding]; other site 314225005767 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 314225005768 G1 box; other site 314225005769 GTP/Mg2+ binding site [chemical binding]; other site 314225005770 Switch I region; other site 314225005771 G2 box; other site 314225005772 G3 box; other site 314225005773 Switch II region; other site 314225005774 G4 box; other site 314225005775 G5 box; other site 314225005776 membrane protein insertase; Provisional; Region: PRK01318 314225005777 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 314225005778 Haemolytic domain; Region: Haemolytic; pfam01809 314225005779 Ribonuclease P; Region: Ribonuclease_P; pfam00825 314225005780 Predicted periplasmic protein [Function unknown]; Region: COG3904 314225005781 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 314225005782 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 314225005783 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 314225005784 Helix-turn-helix domain; Region: HTH_28; pfam13518 314225005785 putative transposase OrfB; Reviewed; Region: PHA02517 314225005786 Homeodomain-like domain; Region: HTH_32; pfam13565 314225005787 Integrase core domain; Region: rve; pfam00665 314225005788 Integrase core domain; Region: rve_3; pfam13683 314225005789 Transposase; Region: HTH_Tnp_1; pfam01527 314225005790 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 314225005791 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 314225005792 Putative cyclase; Region: Cyclase; pfam04199 314225005793 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 314225005794 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 314225005795 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 314225005796 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 314225005797 NAD(P) binding site [chemical binding]; other site 314225005798 catalytic residues [active] 314225005799 choline dehydrogenase; Validated; Region: PRK02106 314225005800 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 314225005801 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 314225005802 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 314225005803 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 314225005804 acyl-activating enzyme (AAE) consensus motif; other site 314225005805 acyl-activating enzyme (AAE) consensus motif; other site 314225005806 putative AMP binding site [chemical binding]; other site 314225005807 putative active site [active] 314225005808 putative CoA binding site [chemical binding]; other site 314225005809 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 314225005810 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 314225005811 substrate binding site [chemical binding]; other site 314225005812 oxyanion hole (OAH) forming residues; other site 314225005813 trimer interface [polypeptide binding]; other site 314225005814 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 314225005815 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 314225005816 active site 314225005817 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 314225005818 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 314225005819 active site 314225005820 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 314225005821 homodimer interface [polypeptide binding]; other site 314225005822 NAD binding site [chemical binding]; other site 314225005823 short chain dehydrogenase; Provisional; Region: PRK06172 314225005824 active site 314225005825 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 314225005826 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 314225005827 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 314225005828 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 314225005829 Transcriptional regulator [Transcription]; Region: LysR; COG0583 314225005830 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 314225005831 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 314225005832 dimerization interface [polypeptide binding]; other site 314225005833 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 314225005834 CoA-transferase family III; Region: CoA_transf_3; pfam02515 314225005835 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 314225005836 dimerization interface [polypeptide binding]; other site 314225005837 putative DNA binding site [nucleotide binding]; other site 314225005838 putative Zn2+ binding site [ion binding]; other site 314225005839 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 314225005840 HTH-like domain; Region: HTH_21; pfam13276 314225005841 Integrase core domain; Region: rve; pfam00665 314225005842 Integrase core domain; Region: rve_3; pfam13683 314225005843 Transposase; Region: HTH_Tnp_1; pfam01527 314225005844 Predicted permease; Region: DUF318; cl17795 314225005845 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 314225005846 Transposase; Region: DDE_Tnp_ISL3; pfam01610 314225005847 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 314225005848 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 314225005849 cobalamin binding residues [chemical binding]; other site 314225005850 putative BtuC binding residues; other site 314225005851 dimer interface [polypeptide binding]; other site 314225005852 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 314225005853 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 314225005854 N-terminal plug; other site 314225005855 ligand-binding site [chemical binding]; other site 314225005856 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 314225005857 active site 314225005858 Int/Topo IB signature motif; other site 314225005859 DNA binding site [nucleotide binding] 314225005860 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 314225005861 Chromate transporter; Region: Chromate_transp; pfam02417 314225005862 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 314225005863 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 314225005864 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 314225005865 ABC1 family; Region: ABC1; cl17513 314225005866 TniQ; Region: TniQ; pfam06527 314225005867 Bacterial TniB protein; Region: TniB; pfam05621 314225005868 AAA domain; Region: AAA_22; pfam13401 314225005869 Winged helix-turn helix; Region: HTH_29; pfam13551 314225005870 Integrase core domain; Region: rve; pfam00665 314225005871 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 314225005872 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 314225005873 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 314225005874 PRC-barrel domain; Region: PRC; pfam05239 314225005875 Predicted transcriptional regulators [Transcription]; Region: COG1733 314225005876 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 314225005877 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 314225005878 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 314225005879 motif II; other site 314225005880 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 314225005881 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 314225005882 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 314225005883 NAD binding site [chemical binding]; other site 314225005884 homodimer interface [polypeptide binding]; other site 314225005885 active site 314225005886 substrate binding site [chemical binding]; other site 314225005887 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 314225005888 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 314225005889 active site 314225005890 Zn binding site [ion binding]; other site 314225005891 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 314225005892 putative catalytic site [active] 314225005893 putative metal binding site [ion binding]; other site 314225005894 putative phosphate binding site [ion binding]; other site 314225005895 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 314225005896 active site 314225005897 catalytic motif [active] 314225005898 Zn binding site [ion binding]; other site 314225005899 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 314225005900 GIY-YIG motif/motif A; other site 314225005901 putative active site [active] 314225005902 putative metal binding site [ion binding]; other site 314225005903 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 314225005904 active site 314225005905 hypothetical protein; Provisional; Region: PRK02853 314225005906 replicative DNA helicase; Provisional; Region: PRK09165 314225005907 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 314225005908 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 314225005909 Walker A motif; other site 314225005910 ATP binding site [chemical binding]; other site 314225005911 Walker B motif; other site 314225005912 DNA binding loops [nucleotide binding] 314225005913 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 314225005914 PLD-like domain; Region: PLDc_2; pfam13091 314225005915 putative active site [active] 314225005916 catalytic site [active] 314225005917 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 314225005918 PLD-like domain; Region: PLDc_2; pfam13091 314225005919 putative active site [active] 314225005920 catalytic site [active] 314225005921 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 314225005922 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 314225005923 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 314225005924 P-loop; other site 314225005925 Magnesium ion binding site [ion binding]; other site 314225005926 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 314225005927 Magnesium ion binding site [ion binding]; other site 314225005928 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 314225005929 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 314225005930 Double zinc ribbon; Region: DZR; pfam12773 314225005931 Protein of unknown function (DUF3667); Region: DUF3667; pfam12412 314225005932 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 314225005933 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 314225005934 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 314225005935 Walker A motif; other site 314225005936 ATP binding site [chemical binding]; other site 314225005937 Walker B motif; other site 314225005938 arginine finger; other site 314225005939 Peptidase family M41; Region: Peptidase_M41; pfam01434 314225005940 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 314225005941 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 314225005942 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 314225005943 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 314225005944 hydrophobic ligand binding site; other site 314225005945 Protein of unknown function (DUF1761); Region: DUF1761; pfam08570 314225005946 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 314225005947 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 314225005948 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 314225005949 DevC protein; Region: devC; TIGR01185 314225005950 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 314225005951 FtsX-like permease family; Region: FtsX; pfam02687 314225005952 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 314225005953 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 314225005954 Walker A/P-loop; other site 314225005955 ATP binding site [chemical binding]; other site 314225005956 Q-loop/lid; other site 314225005957 ABC transporter signature motif; other site 314225005958 Walker B; other site 314225005959 D-loop; other site 314225005960 H-loop/switch region; other site 314225005961 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 314225005962 HlyD family secretion protein; Region: HlyD_3; pfam13437 314225005963 Outer membrane efflux protein; Region: OEP; pfam02321 314225005964 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 314225005965 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 314225005966 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 314225005967 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 314225005968 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 314225005969 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 314225005970 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 314225005971 active site 314225005972 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 314225005973 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 314225005974 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 314225005975 catalytic site [active] 314225005976 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 314225005977 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 314225005978 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 314225005979 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 314225005980 putative homodimer interface [polypeptide binding]; other site 314225005981 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 314225005982 heterodimer interface [polypeptide binding]; other site 314225005983 homodimer interface [polypeptide binding]; other site 314225005984 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 314225005985 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 314225005986 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 314225005987 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 314225005988 Peptidase family M23; Region: Peptidase_M23; pfam01551 314225005989 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 314225005990 Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; pfam09923 314225005991 NADH dehydrogenase; Validated; Region: PRK08183 314225005992 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 314225005993 RecX family; Region: RecX; pfam02631 314225005994 acyl-CoA synthetase; Validated; Region: PRK09192 314225005995 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 314225005996 acyl-activating enzyme (AAE) consensus motif; other site 314225005997 active site 314225005998 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 314225005999 Uncharacterized conserved protein CG6151-P; Region: Cg6151-P; cl10918 314225006000 Gram-negative bacterial tonB protein; Region: TonB; cl10048 314225006001 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 314225006002 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 314225006003 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 314225006004 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 314225006005 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 314225006006 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 314225006007 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 314225006008 Nucleoside recognition; Region: Gate; pfam07670 314225006009 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 314225006010 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 314225006011 PilZ domain; Region: PilZ; pfam07238 314225006012 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 314225006013 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 314225006014 non-specific DNA binding site [nucleotide binding]; other site 314225006015 salt bridge; other site 314225006016 sequence-specific DNA binding site [nucleotide binding]; other site 314225006017 PAS fold; Region: PAS_4; pfam08448 314225006018 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 314225006019 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 314225006020 metal binding site [ion binding]; metal-binding site 314225006021 active site 314225006022 I-site; other site 314225006023 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 314225006024 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 314225006025 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 314225006026 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 314225006027 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 314225006028 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 314225006029 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 314225006030 active site 314225006031 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 314225006032 metal-binding site 314225006033 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 314225006034 XdhC Rossmann domain; Region: XdhC_C; pfam13478 314225006035 Cytochrome c; Region: Cytochrom_C; cl11414 314225006036 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 314225006037 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 314225006038 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 314225006039 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 314225006040 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 314225006041 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 314225006042 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 314225006043 catalytic loop [active] 314225006044 iron binding site [ion binding]; other site 314225006045 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 314225006046 HAMP domain; Region: HAMP; pfam00672 314225006047 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 314225006048 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 314225006049 dimer interface [polypeptide binding]; other site 314225006050 putative CheW interface [polypeptide binding]; other site 314225006051 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 314225006052 metal binding site [ion binding]; metal-binding site 314225006053 active site 314225006054 I-site; other site 314225006055 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 314225006056 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 314225006057 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 314225006058 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 314225006059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 314225006060 active site 314225006061 phosphorylation site [posttranslational modification] 314225006062 intermolecular recognition site; other site 314225006063 CheB methylesterase; Region: CheB_methylest; pfam01339 314225006064 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 314225006065 Response regulator receiver domain; Region: Response_reg; pfam00072 314225006066 active site 314225006067 phosphorylation site [posttranslational modification] 314225006068 intermolecular recognition site; other site 314225006069 dimerization interface [polypeptide binding]; other site 314225006070 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 314225006071 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 314225006072 putative binding surface; other site 314225006073 active site 314225006074 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 314225006075 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 314225006076 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 314225006077 ATP binding site [chemical binding]; other site 314225006078 Mg2+ binding site [ion binding]; other site 314225006079 G-X-G motif; other site 314225006080 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 314225006081 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); Region: HPPK; pfam01288 314225006082 catalytic center binding site [active] 314225006083 ATP binding site [chemical binding]; other site 314225006084 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 314225006085 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 314225006086 putative active site; other site 314225006087 catalytic triad [active] 314225006088 putative dimer interface [polypeptide binding]; other site 314225006089 Uncharacterized conserved protein [Function unknown]; Region: COG2968 314225006090 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 314225006091 Predicted methyltransferase [General function prediction only]; Region: COG4798 314225006092 methionine sulfoxide reductase A; Provisional; Region: PRK14054 314225006093 NusB family; Region: NusB; pfam01029 314225006094 putative RNA binding site [nucleotide binding]; other site 314225006095 16S rRNA methyltransferase B; Provisional; Region: PRK10901 314225006096 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 314225006097 S-adenosylmethionine binding site [chemical binding]; other site 314225006098 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 314225006099 Uncharacterized conserved small protein [Function unknown]; Region: COG5508 314225006100 Cytochrome P450; Region: p450; cl12078 314225006101 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 314225006102 ferrochelatase; Reviewed; Region: hemH; PRK00035 314225006103 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 314225006104 C-terminal domain interface [polypeptide binding]; other site 314225006105 active site 314225006106 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 314225006107 active site 314225006108 N-terminal domain interface [polypeptide binding]; other site 314225006109 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 314225006110 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 314225006111 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 314225006112 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 314225006113 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 314225006114 Walker A motif; other site 314225006115 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 314225006116 HflK protein; Region: hflK; TIGR01933 314225006117 HflC protein; Region: hflC; TIGR01932 314225006118 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 314225006119 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 314225006120 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 314225006121 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 314225006122 protein binding site [polypeptide binding]; other site 314225006123 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 314225006124 protein binding site [polypeptide binding]; other site 314225006125 Transglycosylase; Region: Transgly; pfam00912 314225006126 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 314225006127 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 314225006128 methionine sulfoxide reductase B; Provisional; Region: PRK00222 314225006129 SelR domain; Region: SelR; pfam01641 314225006130 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 314225006131 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 314225006132 C-terminal domain interface [polypeptide binding]; other site 314225006133 GSH binding site (G-site) [chemical binding]; other site 314225006134 dimer interface [polypeptide binding]; other site 314225006135 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 314225006136 N-terminal domain interface [polypeptide binding]; other site 314225006137 dimer interface [polypeptide binding]; other site 314225006138 substrate binding pocket (H-site) [chemical binding]; other site 314225006139 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 314225006140 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 314225006141 tetramerization interface [polypeptide binding]; other site 314225006142 NAD(P) binding site [chemical binding]; other site 314225006143 catalytic residues [active] 314225006144 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 314225006145 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 314225006146 substrate binding site [chemical binding]; other site 314225006147 catalytic Zn binding site [ion binding]; other site 314225006148 NAD binding site [chemical binding]; other site 314225006149 structural Zn binding site [ion binding]; other site 314225006150 dimer interface [polypeptide binding]; other site 314225006151 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 314225006152 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 314225006153 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 314225006154 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 314225006155 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 314225006156 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 314225006157 putative deacylase active site [active] 314225006158 S-formylglutathione hydrolase; Region: PLN02442 314225006159 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 314225006160 Methyltransferase domain; Region: Methyltransf_23; pfam13489 314225006161 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 314225006162 S-adenosylmethionine binding site [chemical binding]; other site 314225006163 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 314225006164 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 314225006165 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 314225006166 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 314225006167 pyridoxal 5'-phosphate binding site [chemical binding]; other site 314225006168 homodimer interface [polypeptide binding]; other site 314225006169 catalytic residue [active] 314225006170 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 314225006171 prephenate dehydrogenase; Validated; Region: PRK08507 314225006172 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 314225006173 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 314225006174 putative acyl-acceptor binding pocket; other site 314225006175 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 314225006176 putative active site [active] 314225006177 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 314225006178 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 314225006179 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 314225006180 Walker A/P-loop; other site 314225006181 ATP binding site [chemical binding]; other site 314225006182 Q-loop/lid; other site 314225006183 ABC transporter signature motif; other site 314225006184 Walker B; other site 314225006185 D-loop; other site 314225006186 H-loop/switch region; other site 314225006187 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 314225006188 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 314225006189 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 314225006190 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 314225006191 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 314225006192 short chain dehydrogenase; Provisional; Region: PRK07677 314225006193 NAD(P) binding site [chemical binding]; other site 314225006194 substrate binding site [chemical binding]; other site 314225006195 homotetramer interface [polypeptide binding]; other site 314225006196 active site 314225006197 homodimer interface [polypeptide binding]; other site 314225006198 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 314225006199 Proline dehydrogenase; Region: Pro_dh; pfam01619 314225006200 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 314225006201 Glutamate binding site [chemical binding]; other site 314225006202 NAD binding site [chemical binding]; other site 314225006203 catalytic residues [active] 314225006204 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 314225006205 trimer interface [polypeptide binding]; other site 314225006206 active site 314225006207 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 314225006208 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 314225006209 catalytic triad [active] 314225006210 dimer interface [polypeptide binding]; other site 314225006211 Ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding domain of the alpha/beta class and a discrete (usually N-terminal) domain which varies in orientation with respect to the NAD(P) binding domain. The N-terminal region...; Region: FNR_like_1; cd06196 314225006212 FAD binding pocket [chemical binding]; other site 314225006213 FAD binding motif [chemical binding]; other site 314225006214 phosphate binding motif [ion binding]; other site 314225006215 beta-alpha-beta structure motif; other site 314225006216 NAD binding pocket [chemical binding]; other site 314225006217 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 314225006218 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 314225006219 active site 314225006220 Uncharacterized conserved protein [Function unknown]; Region: COG3268 314225006221 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 314225006222 NAD(P) binding site [chemical binding]; other site 314225006223 Predicted membrane protein [Function unknown]; Region: COG2259 314225006224 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 314225006225 N-terminal plug; other site 314225006226 ligand-binding site [chemical binding]; other site 314225006227 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 314225006228 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 314225006229 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 314225006230 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 314225006231 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 314225006232 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 314225006233 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 314225006234 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 314225006235 homodimer interface [polypeptide binding]; other site 314225006236 NADP binding site [chemical binding]; other site 314225006237 substrate binding site [chemical binding]; other site 314225006238 YGGT family; Region: YGGT; cl00508 314225006239 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 314225006240 feedback inhibition sensing region; other site 314225006241 homohexameric interface [polypeptide binding]; other site 314225006242 nucleotide binding site [chemical binding]; other site 314225006243 N-acetyl-L-glutamate binding site [chemical binding]; other site 314225006244 Staphylococcal nuclease homologues; Region: SNc; smart00318 314225006245 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 314225006246 putative active site [active] 314225006247 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 314225006248 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 314225006249 dimer interface [polypeptide binding]; other site 314225006250 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 314225006251 putative radical transfer pathway; other site 314225006252 diiron center [ion binding]; other site 314225006253 tyrosyl radical; other site 314225006254 Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; pfam09939 314225006255 Citrate transporter; Region: CitMHS; pfam03600 314225006256 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 314225006257 putative active site [active] 314225006258 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102 314225006259 Class I ribonucleotide reductase; Region: RNR_I; cd01679 314225006260 active site 314225006261 dimer interface [polypeptide binding]; other site 314225006262 catalytic residues [active] 314225006263 effector binding site; other site 314225006264 R2 peptide binding site; other site 314225006265 acyl transferase; Provisional; Region: luxD; PRK13604 314225006266 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 314225006267 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 314225006268 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 314225006269 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 314225006270 L-aspartate oxidase; Provisional; Region: PRK09077 314225006271 L-aspartate oxidase; Provisional; Region: PRK06175 314225006272 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 314225006273 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 314225006274 S-adenosylmethionine binding site [chemical binding]; other site 314225006275 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 314225006276 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 314225006277 Walker A/P-loop; other site 314225006278 ATP binding site [chemical binding]; other site 314225006279 Q-loop/lid; other site 314225006280 ABC transporter signature motif; other site 314225006281 Walker B; other site 314225006282 D-loop; other site 314225006283 H-loop/switch region; other site 314225006284 Zinc-finger domain; Region: zf-CHCC; pfam10276 314225006285 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 314225006286 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 314225006287 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 314225006288 minor groove reading motif; other site 314225006289 helix-hairpin-helix signature motif; other site 314225006290 substrate binding pocket [chemical binding]; other site 314225006291 active site 314225006292 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 314225006293 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 314225006294 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 314225006295 minor groove reading motif; other site 314225006296 helix-hairpin-helix signature motif; other site 314225006297 substrate binding pocket [chemical binding]; other site 314225006298 active site 314225006299 GMP synthase; Reviewed; Region: guaA; PRK00074 314225006300 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 314225006301 AMP/PPi binding site [chemical binding]; other site 314225006302 candidate oxyanion hole; other site 314225006303 catalytic triad [active] 314225006304 potential glutamine specificity residues [chemical binding]; other site 314225006305 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 314225006306 ATP Binding subdomain [chemical binding]; other site 314225006307 Ligand Binding sites [chemical binding]; other site 314225006308 Dimerization subdomain; other site 314225006309 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 314225006310 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 314225006311 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 314225006312 acyl-activating enzyme (AAE) consensus motif; other site 314225006313 acyl-activating enzyme (AAE) consensus motif; other site 314225006314 putative AMP binding site [chemical binding]; other site 314225006315 putative active site [active] 314225006316 putative CoA binding site [chemical binding]; other site 314225006317 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 314225006318 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 314225006319 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 314225006320 Mg2+ binding site [ion binding]; other site 314225006321 G-X-G motif; other site 314225006322 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 314225006323 anchoring element; other site 314225006324 dimer interface [polypeptide binding]; other site 314225006325 ATP binding site [chemical binding]; other site 314225006326 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 314225006327 active site 314225006328 putative metal-binding site [ion binding]; other site 314225006329 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 314225006330 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 314225006331 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 314225006332 Domain of unknown function DUF20; Region: UPF0118; pfam01594 314225006333 HI0933-like protein; Region: HI0933_like; pfam03486 314225006334 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 314225006335 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 314225006336 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 314225006337 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 314225006338 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 314225006339 putative acyl-acceptor binding pocket; other site 314225006340 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 314225006341 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 314225006342 Uncharacterized protein family (UPF0167); Region: UPF0167; cl01252 314225006343 isovaleryl-CoA dehydrogenase; Region: PLN02519 314225006344 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 314225006345 active site 314225006346 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 314225006347 GAF domain; Region: GAF; pfam01590 314225006348 PAS domain S-box; Region: sensory_box; TIGR00229 314225006349 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 314225006350 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 314225006351 HWE histidine kinase; Region: HWE_HK; smart00911 314225006352 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 314225006353 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 314225006354 Walker A/P-loop; other site 314225006355 ATP binding site [chemical binding]; other site 314225006356 Q-loop/lid; other site 314225006357 ABC transporter signature motif; other site 314225006358 Walker B; other site 314225006359 D-loop; other site 314225006360 H-loop/switch region; other site 314225006361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 314225006362 dimer interface [polypeptide binding]; other site 314225006363 conserved gate region; other site 314225006364 putative PBP binding loops; other site 314225006365 ABC-ATPase subunit interface; other site 314225006366 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 314225006367 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 314225006368 Uncharacterized conserved protein [Function unknown]; Region: COG1565 314225006369 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 314225006370 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 314225006371 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 314225006372 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 314225006373 acyl-activating enzyme (AAE) consensus motif; other site 314225006374 acyl-activating enzyme (AAE) consensus motif; other site 314225006375 putative AMP binding site [chemical binding]; other site 314225006376 putative active site [active] 314225006377 putative CoA binding site [chemical binding]; other site 314225006378 PII uridylyl-transferase; Provisional; Region: PRK05092 314225006379 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 314225006380 metal binding triad; other site 314225006381 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 314225006382 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 314225006383 Zn2+ binding site [ion binding]; other site 314225006384 Mg2+ binding site [ion binding]; other site 314225006385 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 314225006386 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 314225006387 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 314225006388 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 314225006389 ligand binding site [chemical binding]; other site 314225006390 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 314225006391 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 314225006392 catalytic residue [active] 314225006393 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 314225006394 thiamine phosphate binding site [chemical binding]; other site 314225006395 active site 314225006396 pyrophosphate binding site [ion binding]; other site 314225006397 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 314225006398 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 314225006399 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 314225006400 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 314225006401 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 314225006402 Domain of unknown function (DUF389); Region: DUF389; pfam04087 314225006403 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 314225006404 Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746 314225006405 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 314225006406 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 314225006407 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 314225006408 hexamer interface [polypeptide binding]; other site 314225006409 ligand binding site [chemical binding]; other site 314225006410 putative active site [active] 314225006411 NAD(P) binding site [chemical binding]; other site 314225006412 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 314225006413 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 314225006414 putative active site [active] 314225006415 putative FMN binding site [chemical binding]; other site 314225006416 putative substrate binding site [chemical binding]; other site 314225006417 putative catalytic residue [active] 314225006418 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 314225006419 active site 314225006420 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 314225006421 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 314225006422 motif II; other site 314225006423 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 314225006424 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 314225006425 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 314225006426 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 314225006427 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 314225006428 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 314225006429 active site 314225006430 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 314225006431 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 314225006432 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 314225006433 active site 314225006434 phosphorylation site [posttranslational modification] 314225006435 intermolecular recognition site; other site 314225006436 dimerization interface [polypeptide binding]; other site 314225006437 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 314225006438 DNA binding site [nucleotide binding] 314225006439 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 314225006440 dimer interface [polypeptide binding]; other site 314225006441 phosphorylation site [posttranslational modification] 314225006442 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 314225006443 ATP binding site [chemical binding]; other site 314225006444 Mg2+ binding site [ion binding]; other site 314225006445 G-X-G motif; other site 314225006446 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 314225006447 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 314225006448 Glutathione S-transferase, C-terminal domain; Region: GST_C_2; pfam13410 314225006449 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 314225006450 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 314225006451 Walker A motif; other site 314225006452 ATP binding site [chemical binding]; other site 314225006453 aminodeoxychorismate synthase; Provisional; Region: PRK07508 314225006454 chorismate binding enzyme; Region: Chorismate_bind; cl10555 314225006455 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 314225006456 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 314225006457 substrate-cofactor binding pocket; other site 314225006458 homodimer interface [polypeptide binding]; other site 314225006459 pyridoxal 5'-phosphate binding site [chemical binding]; other site 314225006460 catalytic residue [active] 314225006461 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 314225006462 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 314225006463 active site 314225006464 hypothetical protein; Provisional; Region: PRK09256 314225006465 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 314225006466 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 314225006467 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 314225006468 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 314225006469 dimer interface [polypeptide binding]; other site 314225006470 Alkaline phosphatase homologues; Region: alkPPc; smart00098 314225006471 active site 314225006472 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 314225006473 putative catalytic site [active] 314225006474 putative phosphate binding site [ion binding]; other site 314225006475 active site 314225006476 metal binding site A [ion binding]; metal-binding site 314225006477 DNA binding site [nucleotide binding] 314225006478 putative AP binding site [nucleotide binding]; other site 314225006479 putative metal binding site B [ion binding]; other site 314225006480 GTP cyclohydrolase; Provisional; Region: PRK08815 314225006481 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 314225006482 dimerization interface [polypeptide binding]; other site 314225006483 active site 314225006484 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 314225006485 Coenzyme A binding pocket [chemical binding]; other site 314225006486 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 314225006487 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 314225006488 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 314225006489 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 314225006490 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 314225006491 ATP binding site [chemical binding]; other site 314225006492 putative Mg++ binding site [ion binding]; other site 314225006493 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 314225006494 nucleotide binding region [chemical binding]; other site 314225006495 ATP-binding site [chemical binding]; other site 314225006496 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 314225006497 HRDC domain; Region: HRDC; pfam00570 314225006498 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 314225006499 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 314225006500 active site 314225006501 mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253 314225006502 CoA-transferase family III; Region: CoA_transf_3; pfam02515 314225006503 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 314225006504 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 314225006505 dimer interface [polypeptide binding]; other site 314225006506 active site 314225006507 Uncharacterized conserved protein [Function unknown]; Region: COG3777 314225006508 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 314225006509 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 314225006510 active site 2 [active] 314225006511 active site 1 [active] 314225006512 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 314225006513 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 314225006514 cofactor binding site; other site 314225006515 metal binding site [ion binding]; metal-binding site 314225006516 Bacitracin resistance protein BacA; Region: BacA; pfam02673 314225006517 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 314225006518 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 314225006519 active site 314225006520 Zn binding site [ion binding]; other site 314225006521 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 314225006522 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 314225006523 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 314225006524 Walker A/P-loop; other site 314225006525 ATP binding site [chemical binding]; other site 314225006526 Q-loop/lid; other site 314225006527 ABC transporter signature motif; other site 314225006528 Walker B; other site 314225006529 D-loop; other site 314225006530 H-loop/switch region; other site 314225006531 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 314225006532 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 314225006533 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 314225006534 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 314225006535 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 314225006536 dimer interface [polypeptide binding]; other site 314225006537 active site 314225006538 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 314225006539 putative active site [active] 314225006540 putative catalytic site [active] 314225006541 Sulfatase; Region: Sulfatase; cl17466 314225006542 O-Antigen ligase; Region: Wzy_C; cl04850 314225006543 PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063 314225006544 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 314225006545 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 314225006546 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 314225006547 active site 314225006548 dimer interface [polypeptide binding]; other site 314225006549 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 314225006550 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 314225006551 active site 314225006552 FMN binding site [chemical binding]; other site 314225006553 substrate binding site [chemical binding]; other site 314225006554 3Fe-4S cluster binding site [ion binding]; other site 314225006555 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 314225006556 domain interface; other site 314225006557 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 314225006558 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 314225006559 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 314225006560 enoyl-CoA hydratase; Provisional; Region: PRK06190 314225006561 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 314225006562 substrate binding site [chemical binding]; other site 314225006563 oxyanion hole (OAH) forming residues; other site 314225006564 trimer interface [polypeptide binding]; other site 314225006565 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 314225006566 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 314225006567 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 314225006568 ligand binding site [chemical binding]; other site 314225006569 active site 314225006570 UGI interface [polypeptide binding]; other site 314225006571 catalytic site [active] 314225006572 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 314225006573 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 314225006574 catalytic site [active] 314225006575 putative active site [active] 314225006576 putative substrate binding site [chemical binding]; other site 314225006577 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 314225006578 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 314225006579 OstA-like protein; Region: OstA; pfam03968 314225006580 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 314225006581 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 314225006582 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 314225006583 SLBB domain; Region: SLBB; pfam10531 314225006584 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 314225006585 Chain length determinant protein; Region: Wzz; cl15801 314225006586 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 314225006587 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 314225006588 putative trimer interface [polypeptide binding]; other site 314225006589 putative active site [active] 314225006590 putative substrate binding site [chemical binding]; other site 314225006591 putative CoA binding site [chemical binding]; other site 314225006592 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 314225006593 active site 314225006594 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 314225006595 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 314225006596 putative metal binding site; other site 314225006597 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 314225006598 active site 314225006599 oxyanion hole [active] 314225006600 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 314225006601 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 314225006602 putative ADP-binding pocket [chemical binding]; other site 314225006603 putative glycosyl transferase; Provisional; Region: PRK10307 314225006604 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 314225006605 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 314225006606 Bacterial sugar transferase; Region: Bac_transf; pfam02397 314225006607 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 314225006608 Lipopolysaccharide-assembly; Region: LptE; pfam04390 314225006609 Domain of unknown function (DUF3576); Region: DUF3576; pfam12100 314225006610 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 314225006611 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 314225006612 NAD(P) binding site [chemical binding]; other site 314225006613 homotetramer interface [polypeptide binding]; other site 314225006614 homodimer interface [polypeptide binding]; other site 314225006615 active site 314225006616 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 314225006617 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 314225006618 DNA binding residues [nucleotide binding] 314225006619 dimerization interface [polypeptide binding]; other site 314225006620 Protein of unknown function (DUF4019); Region: DUF4019; pfam13211 314225006621 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 314225006622 putative acetyltransferase; Provisional; Region: PRK03624 314225006623 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 314225006624 Coenzyme A binding pocket [chemical binding]; other site 314225006625 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 314225006626 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 314225006627 hinge; other site 314225006628 active site 314225006629 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 314225006630 active site 314225006631 tetramer interface; other site 314225006632 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 314225006633 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 314225006634 NAD(P) binding site [chemical binding]; other site 314225006635 active site 314225006636 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 314225006637 Cytochrome P450; Region: p450; cl12078 314225006638 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 314225006639 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 314225006640 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 314225006641 acyl-activating enzyme (AAE) consensus motif; other site 314225006642 acyl-activating enzyme (AAE) consensus motif; other site 314225006643 putative AMP binding site [chemical binding]; other site 314225006644 putative active site [active] 314225006645 putative CoA binding site [chemical binding]; other site 314225006646 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 314225006647 Peptidase family M23; Region: Peptidase_M23; pfam01551 314225006648 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 314225006649 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 314225006650 catalytic triad [active] 314225006651 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 314225006652 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 314225006653 metal binding triad; other site 314225006654 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 314225006655 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 314225006656 metal binding triad; other site 314225006657 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 314225006658 PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821 314225006659 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 314225006660 PA/protease or protease-like domain interface [polypeptide binding]; other site 314225006661 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660 314225006662 metal binding site [ion binding]; metal-binding site 314225006663 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 314225006664 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 314225006665 Protein of unknown function (DUF1223); Region: DUF1223; pfam06764 314225006666 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 314225006667 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 314225006668 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 314225006669 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 314225006670 active site 314225006671 dimer interface [polypeptide binding]; other site 314225006672 motif 1; other site 314225006673 motif 2; other site 314225006674 motif 3; other site 314225006675 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 314225006676 anticodon binding site; other site 314225006677 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 314225006678 PhoD-like phosphatase; Region: PhoD; pfam09423 314225006679 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 314225006680 putative active site [active] 314225006681 putative metal binding site [ion binding]; other site 314225006682 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 314225006683 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 314225006684 non-specific DNA binding site [nucleotide binding]; other site 314225006685 salt bridge; other site 314225006686 sequence-specific DNA binding site [nucleotide binding]; other site 314225006687 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 314225006688 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 314225006689 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 314225006690 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 314225006691 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 314225006692 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 314225006693 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 314225006694 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 314225006695 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 314225006696 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 314225006697 CoA-transferase family III; Region: CoA_transf_3; pfam02515 314225006698 epoxyqueuosine reductase; Region: TIGR00276 314225006699 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 314225006700 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 314225006701 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 314225006702 Walker A/P-loop; other site 314225006703 ATP binding site [chemical binding]; other site 314225006704 Q-loop/lid; other site 314225006705 ABC transporter signature motif; other site 314225006706 Walker B; other site 314225006707 D-loop; other site 314225006708 H-loop/switch region; other site 314225006709 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 314225006710 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 314225006711 Cytochrome P450; Region: p450; cl12078 314225006712 methionine sulfoxide reductase B; Provisional; Region: PRK00222 314225006713 SelR domain; Region: SelR; pfam01641 314225006714 Predicted membrane protein [Function unknown]; Region: COG2246 314225006715 GtrA-like protein; Region: GtrA; pfam04138 314225006716 hypothetical protein; Provisional; Region: PRK07208 314225006717 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 314225006718 PilZ domain; Region: PilZ; pfam07238 314225006719 PilZ domain; Region: PilZ; pfam07238 314225006720 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 314225006721 IHF dimer interface [polypeptide binding]; other site 314225006722 IHF - DNA interface [nucleotide binding]; other site 314225006723 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 314225006724 DNA-binding site [nucleotide binding]; DNA binding site 314225006725 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 314225006726 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 314225006727 putative substrate translocation pore; other site 314225006728 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 314225006729 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 314225006730 active site 314225006731 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 314225006732 Amidohydrolase; Region: Amidohydro_4; pfam13147 314225006733 active site 314225006734 NnrU protein; Region: NnrU; pfam07298 314225006735 Predicted transcriptional regulators [Transcription]; Region: COG1733 314225006736 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 314225006737 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 314225006738 CoenzymeA binding site [chemical binding]; other site 314225006739 subunit interaction site [polypeptide binding]; other site 314225006740 PHB binding site; other site 314225006741 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 314225006742 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 314225006743 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 314225006744 TPP-binding site; other site 314225006745 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 314225006746 PYR/PP interface [polypeptide binding]; other site 314225006747 dimer interface [polypeptide binding]; other site 314225006748 TPP binding site [chemical binding]; other site 314225006749 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 314225006750 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 314225006751 metal binding site 2 [ion binding]; metal-binding site 314225006752 putative DNA binding helix; other site 314225006753 metal binding site 1 [ion binding]; metal-binding site 314225006754 dimer interface [polypeptide binding]; other site 314225006755 structural Zn2+ binding site [ion binding]; other site 314225006756 methionine sulfoxide reductase A; Provisional; Region: PRK13014 314225006757 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 314225006758 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 314225006759 purine monophosphate binding site [chemical binding]; other site 314225006760 dimer interface [polypeptide binding]; other site 314225006761 putative catalytic residues [active] 314225006762 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 314225006763 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 314225006764 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 314225006765 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 314225006766 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 314225006767 substrate binding site [chemical binding]; other site 314225006768 hexamer interface [polypeptide binding]; other site 314225006769 metal binding site [ion binding]; metal-binding site 314225006770 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 314225006771 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 314225006772 Ligand Binding Site [chemical binding]; other site 314225006773 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 314225006774 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 314225006775 Walker A/P-loop; other site 314225006776 ATP binding site [chemical binding]; other site 314225006777 Q-loop/lid; other site 314225006778 ABC transporter signature motif; other site 314225006779 Walker B; other site 314225006780 D-loop; other site 314225006781 H-loop/switch region; other site 314225006782 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 314225006783 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 314225006784 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 314225006785 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 314225006786 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 314225006787 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 314225006788 acyl-activating enzyme (AAE) consensus motif; other site 314225006789 acyl-activating enzyme (AAE) consensus motif; other site 314225006790 putative AMP binding site [chemical binding]; other site 314225006791 putative active site [active] 314225006792 putative CoA binding site [chemical binding]; other site 314225006793 TIGR02677 family protein; Region: TIGR02677 314225006794 Protein of unknown function (DUF1052); Region: DUF1052; cl02197 314225006795 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 314225006796 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 314225006797 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 314225006798 Uncharacterized conserved protein [Function unknown]; Region: COG4850 314225006799 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 314225006800 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 314225006801 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 314225006802 substrate binding pocket [chemical binding]; other site 314225006803 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 314225006804 Peptidase family M48; Region: Peptidase_M48; cl12018 314225006805 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 314225006806 binding surface 314225006807 TPR motif; other site 314225006808 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 314225006809 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 314225006810 catalytic residues [active] 314225006811 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 314225006812 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 314225006813 Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564 314225006814 Histidine kinase; Region: His_kinase; pfam06580 314225006815 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 314225006816 ATP binding site [chemical binding]; other site 314225006817 Mg2+ binding site [ion binding]; other site 314225006818 G-X-G motif; other site 314225006819 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 314225006820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 314225006821 active site 314225006822 phosphorylation site [posttranslational modification] 314225006823 intermolecular recognition site; other site 314225006824 dimerization interface [polypeptide binding]; other site 314225006825 LytTr DNA-binding domain; Region: LytTR; smart00850 314225006826 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 314225006827 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 314225006828 NAD(P) binding site [chemical binding]; other site 314225006829 catalytic residues [active] 314225006830 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 314225006831 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 314225006832 dimerization interface [polypeptide binding]; other site 314225006833 active site 314225006834 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 314225006835 B1 nucleotide binding pocket [chemical binding]; other site 314225006836 B2 nucleotide binding pocket [chemical binding]; other site 314225006837 CAS motifs; other site 314225006838 active site 314225006839 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 314225006840 nucleoside/Zn binding site; other site 314225006841 dimer interface [polypeptide binding]; other site 314225006842 catalytic motif [active] 314225006843 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 314225006844 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 314225006845 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 314225006846 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 314225006847 Peptidase family M23; Region: Peptidase_M23; pfam01551 314225006848 Uncharacterized protein conserved in bacteria (DUF2093); Region: DUF2093; pfam09866 314225006849 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 314225006850 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 314225006851 generic binding surface II; other site 314225006852 generic binding surface I; other site 314225006853 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 314225006854 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 314225006855 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 314225006856 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 314225006857 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 314225006858 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 314225006859 substrate binding site [chemical binding]; other site 314225006860 ATP binding site [chemical binding]; other site 314225006861 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 314225006862 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 314225006863 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 314225006864 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 314225006865 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 314225006866 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 314225006867 catalytic residue [active] 314225006868 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 314225006869 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 314225006870 FeS assembly ATPase SufC; Region: sufC; TIGR01978 314225006871 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 314225006872 Walker A/P-loop; other site 314225006873 ATP binding site [chemical binding]; other site 314225006874 Q-loop/lid; other site 314225006875 ABC transporter signature motif; other site 314225006876 Walker B; other site 314225006877 D-loop; other site 314225006878 H-loop/switch region; other site 314225006879 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 314225006880 putative active site [active] 314225006881 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 314225006882 putative ABC transporter; Region: ycf24; CHL00085 314225006883 Rrf2 family protein; Region: rrf2_super; TIGR00738 314225006884 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 314225006885 putative Zn2+ binding site [ion binding]; other site 314225006886 putative DNA binding site [nucleotide binding]; other site 314225006887 dimerization interface [polypeptide binding]; other site 314225006888 Helix-turn-helix domain; Region: HTH_18; pfam12833 314225006889 Helix-turn-helix domain; Region: HTH_18; pfam12833 314225006890 Helix-turn-helix domain; Region: HTH_18; pfam12833 314225006891 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 314225006892 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 314225006893 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 314225006894 quinone interaction residues [chemical binding]; other site 314225006895 active site 314225006896 catalytic residues [active] 314225006897 FMN binding site [chemical binding]; other site 314225006898 substrate binding site [chemical binding]; other site 314225006899 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 314225006900 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 314225006901 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 314225006902 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 314225006903 acyl-activating enzyme (AAE) consensus motif; other site 314225006904 putative AMP binding site [chemical binding]; other site 314225006905 putative active site [active] 314225006906 putative CoA binding site [chemical binding]; other site 314225006907 bifunctional sulfur carrier protein/thiazole synthase protein; Provisional; Region: PRK11840 314225006908 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 314225006909 thiS-thiF/thiG interaction site; other site 314225006910 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 314225006911 ThiS interaction site; other site 314225006912 putative active site [active] 314225006913 tetramer interface [polypeptide binding]; other site 314225006914 MerC mercury resistance protein; Region: MerC; pfam03203 314225006915 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 314225006916 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 314225006917 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 314225006918 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 314225006919 23S rRNA interface [nucleotide binding]; other site 314225006920 L3 interface [polypeptide binding]; other site 314225006921 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 314225006922 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 314225006923 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 314225006924 putative active site [active] 314225006925 putative metal binding site [ion binding]; other site 314225006926 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 314225006927 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 314225006928 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 314225006929 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 314225006930 active site 314225006931 phosphorylation site [posttranslational modification] 314225006932 intermolecular recognition site; other site 314225006933 dimerization interface [polypeptide binding]; other site 314225006934 LytTr DNA-binding domain; Region: LytTR; smart00850 314225006935 Histidine kinase; Region: His_kinase; pfam06580 314225006936 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 314225006937 ATP binding site [chemical binding]; other site 314225006938 Mg2+ binding site [ion binding]; other site 314225006939 G-X-G motif; other site 314225006940 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 314225006941 Fumarase C-terminus; Region: Fumerase_C; pfam05683 314225006942 protein-L-isoaspartate(D-aspartate) O-methyltransferase; Region: pimt; TIGR00080 314225006943 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 314225006944 Protein of unknown function (DUF2497); Region: DUF2497; pfam10691 314225006945 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 314225006946 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 314225006947 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 314225006948 dimer interface [polypeptide binding]; other site 314225006949 [2Fe-2S] cluster binding site [ion binding]; other site 314225006950 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 314225006951 FOG: CBS domain [General function prediction only]; Region: COG0517 314225006952 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 314225006953 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 314225006954 putative catalytic site [active] 314225006955 putative phosphate binding site [ion binding]; other site 314225006956 active site 314225006957 metal binding site A [ion binding]; metal-binding site 314225006958 DNA binding site [nucleotide binding] 314225006959 putative AP binding site [nucleotide binding]; other site 314225006960 putative metal binding site B [ion binding]; other site 314225006961 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 314225006962 Protein of unknown function (DUF1491); Region: DUF1491; pfam07372 314225006963 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 314225006964 CoenzymeA binding site [chemical binding]; other site 314225006965 subunit interaction site [polypeptide binding]; other site 314225006966 PHB binding site; other site 314225006967 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 314225006968 active site 314225006969 phosphorylation site [posttranslational modification] 314225006970 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 314225006971 30S subunit binding site; other site 314225006972 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 314225006973 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 314225006974 active site 314225006975 catalytic site [active] 314225006976 substrate binding site [chemical binding]; other site 314225006977 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 314225006978 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 314225006979 CoA-binding site [chemical binding]; other site 314225006980 ATP-binding [chemical binding]; other site 314225006981 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 314225006982 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 314225006983 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 314225006984 shikimate binding site; other site 314225006985 NAD(P) binding site [chemical binding]; other site 314225006986 Maf-like protein; Region: Maf; pfam02545 314225006987 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 314225006988 putative active site [active] 314225006989 PEP synthetase regulatory protein; Provisional; Region: PRK05339 314225006990 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 314225006991 substrate binding site [chemical binding]; other site 314225006992 active site 314225006993 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 314225006994 transcription termination factor Rho; Provisional; Region: rho; PRK09376 314225006995 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 314225006996 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 314225006997 RNA binding site [nucleotide binding]; other site 314225006998 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 314225006999 multimer interface [polypeptide binding]; other site 314225007000 Walker A motif; other site 314225007001 ATP binding site [chemical binding]; other site 314225007002 Walker B motif; other site 314225007003 Predicted ATPase [General function prediction only]; Region: COG3911 314225007004 AAA domain; Region: AAA_28; pfam13521 314225007005 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 314225007006 PAS domain; Region: PAS_9; pfam13426 314225007007 putative active site [active] 314225007008 heme pocket [chemical binding]; other site 314225007009 PAS domain S-box; Region: sensory_box; TIGR00229 314225007010 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 314225007011 Histidine kinase; Region: HisKA_2; pfam07568 314225007012 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 314225007013 ATP binding site [chemical binding]; other site 314225007014 Mg2+ binding site [ion binding]; other site 314225007015 G-X-G motif; other site 314225007016 SnoaL-like domain; Region: SnoaL_2; pfam12680 314225007017 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 314225007018 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 314225007019 active site 314225007020 FMN binding site [chemical binding]; other site 314225007021 substrate binding site [chemical binding]; other site 314225007022 3Fe-4S cluster binding site [ion binding]; other site 314225007023 Dienelactone hydrolase family; Region: DLH; pfam01738 314225007024 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cl00248 314225007025 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 314225007026 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 314225007027 trmE is a tRNA modification GTPase; Region: trmE; cd04164 314225007028 G1 box; other site 314225007029 GTP/Mg2+ binding site [chemical binding]; other site 314225007030 Switch I region; other site 314225007031 G2 box; other site 314225007032 Switch II region; other site 314225007033 G3 box; other site 314225007034 G4 box; other site 314225007035 G5 box; other site 314225007036 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 314225007037 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 314225007038 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 314225007039 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 314225007040 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 314225007041 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 314225007042 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 314225007043 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 314225007044 P-loop; other site 314225007045 Magnesium ion binding site [ion binding]; other site 314225007046 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 314225007047 Magnesium ion binding site [ion binding]; other site 314225007048 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 314225007049 ParB-like nuclease domain; Region: ParBc; pfam02195 314225007050 KorB domain; Region: KorB; pfam08535 314225007051 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 314225007052 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 314225007053 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 314225007054 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 314225007055 Walker A motif; other site 314225007056 ATP binding site [chemical binding]; other site 314225007057 Walker B motif; other site 314225007058 arginine finger; other site 314225007059 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 314225007060 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 314225007061 active site 314225007062 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 314225007063 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 314225007064 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 314225007065 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 314225007066 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 314225007067 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 314225007068 Ferredoxin [Energy production and conversion]; Region: COG1146 314225007069 4Fe-4S binding domain; Region: Fer4; cl02805 314225007070 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 314225007071 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 314225007072 RNA binding surface [nucleotide binding]; other site 314225007073 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 314225007074 ATP binding site [chemical binding]; other site 314225007075 putative Mg++ binding site [ion binding]; other site 314225007076 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 314225007077 nucleotide binding region [chemical binding]; other site 314225007078 ATP-binding site [chemical binding]; other site 314225007079 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 314225007080 Peptidase family M23; Region: Peptidase_M23; pfam01551 314225007081 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 314225007082 dimer interface [polypeptide binding]; other site 314225007083 active site 314225007084 aspartate-rich active site metal binding site; other site 314225007085 allosteric magnesium binding site [ion binding]; other site 314225007086 Schiff base residues; other site 314225007087 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 314225007088 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 314225007089 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 314225007090 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 314225007091 Coenzyme A binding pocket [chemical binding]; other site 314225007092 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 314225007093 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 314225007094 trimer interface [polypeptide binding]; other site 314225007095 putative metal binding site [ion binding]; other site 314225007096 ATP-dependent DNA ligase; Validated; Region: PRK09247 314225007097 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 314225007098 active site 314225007099 DNA binding site [nucleotide binding] 314225007100 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 314225007101 DNA binding site [nucleotide binding] 314225007102 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 314225007103 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 314225007104 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 314225007105 Clp amino terminal domain; Region: Clp_N; pfam02861 314225007106 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 314225007107 Walker A motif; other site 314225007108 ATP binding site [chemical binding]; other site 314225007109 Walker B motif; other site 314225007110 arginine finger; other site 314225007111 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 314225007112 Walker A motif; other site 314225007113 ATP binding site [chemical binding]; other site 314225007114 Walker B motif; other site 314225007115 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 314225007116 Protein of unknown function (DUF1192); Region: DUF1192; pfam06698 314225007117 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 314225007118 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 314225007119 NAD(P) binding site [chemical binding]; other site 314225007120 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 314225007121 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 314225007122 putative C-terminal domain interface [polypeptide binding]; other site 314225007123 putative GSH binding site (G-site) [chemical binding]; other site 314225007124 putative dimer interface [polypeptide binding]; other site 314225007125 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 314225007126 N-terminal domain interface [polypeptide binding]; other site 314225007127 dimer interface [polypeptide binding]; other site 314225007128 substrate binding pocket (H-site) [chemical binding]; other site 314225007129 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 314225007130 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 314225007131 putative active site [active] 314225007132 putative metal binding site [ion binding]; other site 314225007133 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 314225007134 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 314225007135 Protein of unknown function (DUF1013); Region: DUF1013; pfam06242 314225007136 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 314225007137 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 314225007138 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 314225007139 AMP binding site [chemical binding]; other site 314225007140 active site 314225007141 acyl-activating enzyme (AAE) consensus motif; other site 314225007142 CoA binding site [chemical binding]; other site 314225007143 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 314225007144 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 314225007145 Peptidase family M23; Region: Peptidase_M23; pfam01551 314225007146 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 314225007147 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 314225007148 active site 314225007149 (T/H)XGH motif; other site 314225007150 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 314225007151 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 314225007152 Peptidase family M23; Region: Peptidase_M23; pfam01551 314225007153 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 314225007154 C-terminal peptidase (prc); Region: prc; TIGR00225 314225007155 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 314225007156 protein binding site [polypeptide binding]; other site 314225007157 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 314225007158 Catalytic dyad [active] 314225007159 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 314225007160 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 314225007161 diiron binding motif [ion binding]; other site 314225007162 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 314225007163 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 314225007164 active site 314225007165 homodimer interface [polypeptide binding]; other site 314225007166 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 314225007167 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 314225007168 putative NAD(P) binding site [chemical binding]; other site 314225007169 active site 314225007170 putative substrate binding site [chemical binding]; other site 314225007171 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 314225007172 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 314225007173 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 314225007174 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 314225007175 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 314225007176 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 314225007177 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 314225007178 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 314225007179 trimer interface [polypeptide binding]; other site 314225007180 active site 314225007181 UDP-GlcNAc binding site [chemical binding]; other site 314225007182 lipid binding site [chemical binding]; lipid-binding site 314225007183 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 314225007184 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 314225007185 inhibitor-cofactor binding pocket; inhibition site 314225007186 pyridoxal 5'-phosphate binding site [chemical binding]; other site 314225007187 catalytic residue [active] 314225007188 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 314225007189 TrkA-N domain; Region: TrkA_N; pfam02254 314225007190 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 314225007191 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 314225007192 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 314225007193 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 314225007194 inhibitor-cofactor binding pocket; inhibition site 314225007195 pyridoxal 5'-phosphate binding site [chemical binding]; other site 314225007196 catalytic residue [active] 314225007197 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 314225007198 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 314225007199 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_III; cd01996 314225007200 Ligand Binding Site [chemical binding]; other site 314225007201 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 314225007202 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 314225007203 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 314225007204 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 314225007205 putative trimer interface [polypeptide binding]; other site 314225007206 putative CoA binding site [chemical binding]; other site 314225007207 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 314225007208 Ligand Binding Site [chemical binding]; other site 314225007209 imidazole glycerol phosphate synthase subunit HisF; Provisional; Region: PRK01033 314225007210 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 314225007211 substrate binding site [chemical binding]; other site 314225007212 glutamase interaction surface [polypeptide binding]; other site 314225007213 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 314225007214 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 314225007215 putative active site [active] 314225007216 oxyanion strand; other site 314225007217 catalytic triad [active] 314225007218 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 314225007219 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 314225007220 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 314225007221 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 314225007222 putative trimer interface [polypeptide binding]; other site 314225007223 putative active site [active] 314225007224 putative substrate binding site [chemical binding]; other site 314225007225 putative CoA binding site [chemical binding]; other site 314225007226 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 314225007227 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 314225007228 inhibitor-cofactor binding pocket; inhibition site 314225007229 pyridoxal 5'-phosphate binding site [chemical binding]; other site 314225007230 catalytic residue [active] 314225007231 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 314225007232 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 314225007233 Bacterial sugar transferase; Region: Bac_transf; pfam02397 314225007234 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 314225007235 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 314225007236 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 314225007237 NAD(P) binding site [chemical binding]; other site 314225007238 homodimer interface [polypeptide binding]; other site 314225007239 substrate binding site [chemical binding]; other site 314225007240 active site 314225007241 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 314225007242 Chain length determinant protein; Region: Wzz; cl15801 314225007243 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 314225007244 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 314225007245 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 314225007246 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 314225007247 SLBB domain; Region: SLBB; pfam10531 314225007248 O-Antigen ligase; Region: Wzy_C; pfam04932 314225007249 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 314225007250 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 314225007251 NAD binding site [chemical binding]; other site 314225007252 homotetramer interface [polypeptide binding]; other site 314225007253 homodimer interface [polypeptide binding]; other site 314225007254 substrate binding site [chemical binding]; other site 314225007255 active site 314225007256 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 314225007257 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 314225007258 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 314225007259 HSP70 interaction site [polypeptide binding]; other site 314225007260 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 314225007261 substrate binding site [polypeptide binding]; other site 314225007262 dimer interface [polypeptide binding]; other site 314225007263 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 314225007264 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 314225007265 homotetramer interface [polypeptide binding]; other site 314225007266 NADP-binding site; other site 314225007267 substrate binding site [chemical binding]; other site 314225007268 homodimer interface [polypeptide binding]; other site 314225007269 active site 314225007270 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 314225007271 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 314225007272 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 314225007273 Substrate binding site; other site 314225007274 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 314225007275 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 314225007276 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 314225007277 Cation efflux family; Region: Cation_efflux; cl00316 314225007278 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 314225007279 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 314225007280 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 314225007281 Beta-lactamase; Region: Beta-lactamase; pfam00144 314225007282 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 314225007283 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 314225007284 NADP binding site [chemical binding]; other site 314225007285 active site 314225007286 putative substrate binding site [chemical binding]; other site 314225007287 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 314225007288 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 314225007289 Ligand Binding Site [chemical binding]; other site 314225007290 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 314225007291 Predicted membrane protein [Function unknown]; Region: COG2261 314225007292 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 314225007293 HlyD family secretion protein; Region: HlyD_3; pfam13437 314225007294 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 314225007295 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 314225007296 Protein of unknown function (DUF445); Region: DUF445; pfam04286 314225007297 Erp protein C-terminus; Region: Erp_C; pfam06780 314225007298 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 314225007299 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 314225007300 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 314225007301 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 314225007302 Ligand binding site [chemical binding]; other site 314225007303 Electron transfer flavoprotein domain; Region: ETF; pfam01012 314225007304 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 314225007305 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 314225007306 CoA-ligase; Region: Ligase_CoA; pfam00549 314225007307 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 314225007308 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 314225007309 active site 314225007310 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 314225007311 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 314225007312 ligand binding site [chemical binding]; other site 314225007313 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 314225007314 Domain of unknown function DUF21; Region: DUF21; pfam01595 314225007315 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 314225007316 Transporter associated domain; Region: CorC_HlyC; smart01091 314225007317 Protein of unknown function (DUF3035); Region: DUF3035; pfam11233 314225007318 lipoprotein signal peptidase; Provisional; Region: PRK14787 314225007319 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 314225007320 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 314225007321 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 314225007322 active site 314225007323 HIGH motif; other site 314225007324 nucleotide binding site [chemical binding]; other site 314225007325 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 314225007326 active site 314225007327 KMSKS motif; other site 314225007328 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 314225007329 tRNA binding surface [nucleotide binding]; other site 314225007330 anticodon binding site; other site 314225007331 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 314225007332 EcsC protein family; Region: EcsC; pfam12787 314225007333 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 314225007334 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 314225007335 active site 314225007336 Riboflavin kinase; Region: Flavokinase; smart00904 314225007337 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 314225007338 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 314225007339 active site 314225007340 dimer interface [polypeptide binding]; other site 314225007341 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 314225007342 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 314225007343 folate binding site [chemical binding]; other site 314225007344 NADP+ binding site [chemical binding]; other site 314225007345 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 314225007346 ATP-grasp domain; Region: ATP-grasp; pfam02222 314225007347 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 314225007348 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 314225007349 catalytic core [active] 314225007350 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 314225007351 Uncharacterized conserved protein [Function unknown]; Region: COG3402 314225007352 Predicted membrane protein [Function unknown]; Region: COG3428 314225007353 Bacterial PH domain; Region: DUF304; pfam03703 314225007354 Bacterial PH domain; Region: DUF304; pfam03703 314225007355 Predicted acetyltransferase [General function prediction only]; Region: COG2388 314225007356 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 314225007357 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 314225007358 tetramer interface [polypeptide binding]; other site 314225007359 pyridoxal 5'-phosphate binding site [chemical binding]; other site 314225007360 catalytic residue [active] 314225007361 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 314225007362 EamA-like transporter family; Region: EamA; pfam00892 314225007363 EamA-like transporter family; Region: EamA; pfam00892 314225007364 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 314225007365 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 314225007366 putative NAD(P) binding site [chemical binding]; other site 314225007367 aminopeptidase N; Provisional; Region: pepN; PRK14015 314225007368 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 314225007369 active site 314225007370 Zn binding site [ion binding]; other site 314225007371 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 314225007372 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 314225007373 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 314225007374 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 314225007375 [2Fe-2S] cluster binding site [ion binding]; other site 314225007376 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 314225007377 cytochrome b; Provisional; Region: CYTB; MTH00156 314225007378 interchain domain interface [polypeptide binding]; other site 314225007379 intrachain domain interface; other site 314225007380 heme bH binding site [chemical binding]; other site 314225007381 Qi binding site; other site 314225007382 heme bL binding site [chemical binding]; other site 314225007383 Qo binding site; other site 314225007384 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 314225007385 interchain domain interface [polypeptide binding]; other site 314225007386 intrachain domain interface; other site 314225007387 Qi binding site; other site 314225007388 Qo binding site; other site 314225007389 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 314225007390 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 314225007391 active site 314225007392 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 314225007393 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 314225007394 TrkA-N domain; Region: TrkA_N; pfam02254 314225007395 putative outer membrane lipoprotein; Provisional; Region: PRK09967 314225007396 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 314225007397 ligand binding site [chemical binding]; other site 314225007398 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 314225007399 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 314225007400 active site 314225007401 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 314225007402 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 314225007403 CysD dimerization site [polypeptide binding]; other site 314225007404 G1 box; other site 314225007405 putative GEF interaction site [polypeptide binding]; other site 314225007406 GTP/Mg2+ binding site [chemical binding]; other site 314225007407 Switch I region; other site 314225007408 G2 box; other site 314225007409 G3 box; other site 314225007410 Switch II region; other site 314225007411 G4 box; other site 314225007412 G5 box; other site 314225007413 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 314225007414 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 314225007415 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 314225007416 ligand-binding site [chemical binding]; other site 314225007417 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 314225007418 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 314225007419 Active Sites [active] 314225007420 Peptidase family M48; Region: Peptidase_M48; cl12018 314225007421 CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080 314225007422 pantoate--beta-alanine ligase; Region: panC; TIGR00018 314225007423 Pantoate-beta-alanine ligase; Region: PanC; cd00560 314225007424 active site 314225007425 ATP-binding site [chemical binding]; other site 314225007426 pantoate-binding site; other site 314225007427 HXXH motif; other site 314225007428 ATPase MipZ; Region: MipZ; pfam09140 314225007429 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 314225007430 P-loop; other site 314225007431 Magnesium ion binding site [ion binding]; other site 314225007432 DnaJ domain; Region: DnaJ; pfam00226 314225007433 HSP70 interaction site [polypeptide binding]; other site 314225007434 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 314225007435 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 314225007436 active site 314225007437 substrate binding site [chemical binding]; other site 314225007438 metal binding site [ion binding]; metal-binding site 314225007439 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 314225007440 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 314225007441 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 314225007442 ATP binding site [chemical binding]; other site 314225007443 putative Mg++ binding site [ion binding]; other site 314225007444 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 314225007445 nucleotide binding region [chemical binding]; other site 314225007446 ATP-binding site [chemical binding]; other site 314225007447 DEAD/H associated; Region: DEAD_assoc; pfam08494 314225007448 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 314225007449 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 314225007450 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 314225007451 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 314225007452 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 314225007453 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 314225007454 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 314225007455 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 314225007456 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 314225007457 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 314225007458 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 314225007459 active site 314225007460 homoserine dehydrogenase; Provisional; Region: PRK06349 314225007461 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 314225007462 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 314225007463 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 314225007464 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 314225007465 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 314225007466 putative active site [active] 314225007467 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 314225007468 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 314225007469 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 314225007470 active site 314225007471 Helix-turn-helix domain; Region: HTH_18; pfam12833 314225007472 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 314225007473 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 314225007474 active site 314225007475 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 314225007476 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 314225007477 NAD(P) binding site [chemical binding]; other site 314225007478 active site 314225007479 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 314225007480 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 314225007481 23S rRNA binding site [nucleotide binding]; other site 314225007482 L21 binding site [polypeptide binding]; other site 314225007483 L13 binding site [polypeptide binding]; other site 314225007484 Helix-turn-helix domain; Region: HTH_18; pfam12833 314225007485 Bacterial SH3 domain homologues; Region: SH3b; smart00287 314225007486 Helix-turn-helix domain; Region: HTH_18; pfam12833 314225007487 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 314225007488 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 314225007489 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 314225007490 dimer interface [polypeptide binding]; other site 314225007491 motif 1; other site 314225007492 active site 314225007493 motif 2; other site 314225007494 motif 3; other site 314225007495 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 314225007496 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 314225007497 putative tRNA-binding site [nucleotide binding]; other site 314225007498 B3/4 domain; Region: B3_4; pfam03483 314225007499 tRNA synthetase B5 domain; Region: B5; smart00874 314225007500 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 314225007501 dimer interface [polypeptide binding]; other site 314225007502 motif 1; other site 314225007503 motif 3; other site 314225007504 motif 2; other site 314225007505 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 314225007506 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 314225007507 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 314225007508 G1 box; other site 314225007509 putative GEF interaction site [polypeptide binding]; other site 314225007510 GTP/Mg2+ binding site [chemical binding]; other site 314225007511 Switch I region; other site 314225007512 G2 box; other site 314225007513 G3 box; other site 314225007514 Switch II region; other site 314225007515 G4 box; other site 314225007516 G5 box; other site 314225007517 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 314225007518 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 314225007519 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 314225007520 putative catalytic site [active] 314225007521 putative metal binding site [ion binding]; other site 314225007522 putative phosphate binding site [ion binding]; other site 314225007523 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 314225007524 Nitrogen regulatory protein P-II; Region: P-II; smart00938 314225007525 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 314225007526 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 314225007527 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 314225007528 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 314225007529 choline dehydrogenase; Validated; Region: PRK02106 314225007530 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 314225007531 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 314225007532 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 314225007533 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 314225007534 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 314225007535 putative metal binding site [ion binding]; other site 314225007536 Putative phosphatase (DUF442); Region: DUF442; cl17385 314225007537 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 314225007538 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 314225007539 DNA-binding site [nucleotide binding]; DNA binding site 314225007540 RNA-binding motif; other site 314225007541 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 314225007542 DNA-binding site [nucleotide binding]; DNA binding site 314225007543 RNA-binding motif; other site 314225007544 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 314225007545 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 314225007546 inhibitor-cofactor binding pocket; inhibition site 314225007547 pyridoxal 5'-phosphate binding site [chemical binding]; other site 314225007548 catalytic residue [active] 314225007549 ornithine carbamoyltransferase; Provisional; Region: PRK00779 314225007550 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 314225007551 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 314225007552 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 314225007553 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 314225007554 dimerization interface [polypeptide binding]; other site 314225007555 domain crossover interface; other site 314225007556 redox-dependent activation switch; other site 314225007557 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 314225007558 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 314225007559 Ligand Binding Site [chemical binding]; other site 314225007560 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 314225007561 putative substrate translocation pore; other site 314225007562 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 314225007563 E-class dimer interface [polypeptide binding]; other site 314225007564 P-class dimer interface [polypeptide binding]; other site 314225007565 active site 314225007566 Cu2+ binding site [ion binding]; other site 314225007567 Zn2+ binding site [ion binding]; other site 314225007568 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 314225007569 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 314225007570 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 314225007571 ligand binding site [chemical binding]; other site 314225007572 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 314225007573 Putative phage tail protein; Region: Phage-tail_3; pfam13550 314225007574 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 314225007575 NlpC/P60 family; Region: NLPC_P60; cl17555 314225007576 Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931 314225007577 phage conserved hypothetical protein BR0599; Region: phg_TIGR02218 314225007578 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 314225007579 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343 314225007580 Conserved hypothetical phage protein (DUF2376); Region: DUF2376; pfam09550 314225007581 Protein of unknown function (DUF3356); Region: DUF3356; pfam11836 314225007582 Phage major tail protein 2; Region: Phage_tail_2; pfam06199 314225007583 phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215 314225007584 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 314225007585 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 314225007586 oligomerization interface [polypeptide binding]; other site 314225007587 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 314225007588 Phage capsid family; Region: Phage_capsid; pfam05065 314225007589 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 314225007590 Phage-related protein [Function unknown]; Region: COG4695 314225007591 Phage portal protein; Region: Phage_portal; pfam04860 314225007592 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 314225007593 GIY-YIG motif/motif A; other site 314225007594 putative active site [active] 314225007595 putative metal binding site [ion binding]; other site 314225007596 Uncharacterized conserved protein [Function unknown]; Region: COG5323 314225007597 Terminase-like family; Region: Terminase_6; pfam03237 314225007598 Predicted membrane protein [Function unknown]; Region: COG1238 314225007599 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 314225007600 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 314225007601 ligand binding site [chemical binding]; other site 314225007602 flexible hinge region; other site 314225007603 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 314225007604 putative switch regulator; other site 314225007605 non-specific DNA interactions [nucleotide binding]; other site 314225007606 DNA binding site [nucleotide binding] 314225007607 sequence specific DNA binding site [nucleotide binding]; other site 314225007608 putative cAMP binding site [chemical binding]; other site 314225007609 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 314225007610 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 314225007611 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 314225007612 amphipathic channel; other site 314225007613 Asn-Pro-Ala signature motifs; other site 314225007614 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 314225007615 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 314225007616 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 314225007617 substrate-cofactor binding pocket; other site 314225007618 pyridoxal 5'-phosphate binding site [chemical binding]; other site 314225007619 catalytic residue [active] 314225007620 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 314225007621 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 314225007622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 314225007623 active site 314225007624 phosphorylation site [posttranslational modification] 314225007625 intermolecular recognition site; other site 314225007626 dimerization interface [polypeptide binding]; other site 314225007627 Protein of unknown function (DUF3572); Region: DUF3572; pfam12096 314225007628 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 314225007629 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 314225007630 homotrimer interaction site [polypeptide binding]; other site 314225007631 putative active site [active] 314225007632 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 314225007633 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 314225007634 active site 314225007635 catalytic site [active] 314225007636 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 314225007637 Protein of unknown function, DUF482; Region: DUF482; pfam04339 314225007638 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 314225007639 Sel1 repeat; Region: Sel1; cl02723 314225007640 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 314225007641 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 314225007642 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 314225007643 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 314225007644 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 314225007645 Putative cyclase; Region: Cyclase; cl00814 314225007646 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 314225007647 kynureninase; Region: kynureninase; TIGR01814 314225007648 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 314225007649 catalytic residue [active] 314225007650 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 314225007651 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 314225007652 active site 314225007653 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 314225007654 active site 314225007655 HIGH motif; other site 314225007656 nucleotide binding site [chemical binding]; other site 314225007657 active site 314225007658 KMSKS motif; other site 314225007659 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 314225007660 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 314225007661 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 314225007662 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 314225007663 Domain of unknown function (DUF202); Region: DUF202; pfam02656 314225007664 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 314225007665 MutS domain I; Region: MutS_I; pfam01624 314225007666 MutS domain II; Region: MutS_II; pfam05188 314225007667 MutS domain III; Region: MutS_III; pfam05192 314225007668 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 314225007669 Walker A/P-loop; other site 314225007670 ATP binding site [chemical binding]; other site 314225007671 Q-loop/lid; other site 314225007672 ABC transporter signature motif; other site 314225007673 Walker B; other site 314225007674 D-loop; other site 314225007675 H-loop/switch region; other site 314225007676 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 314225007677 Malic enzyme, N-terminal domain; Region: malic; pfam00390 314225007678 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 314225007679 putative NAD(P) binding site [chemical binding]; other site 314225007680 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 314225007681 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 314225007682 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 314225007683 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 314225007684 catalytic residue [active] 314225007685 Domain of unknown function (DUF892); Region: DUF892; pfam05974 314225007686 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 314225007687 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 314225007688 Active site serine [active] 314225007689 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 314225007690 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 314225007691 active site 314225007692 phosphorylation site [posttranslational modification] 314225007693 intermolecular recognition site; other site 314225007694 dimerization interface [polypeptide binding]; other site 314225007695 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 314225007696 DNA binding site [nucleotide binding] 314225007697 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 314225007698 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 314225007699 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 314225007700 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 314225007701 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 314225007702 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 314225007703 Walker A/P-loop; other site 314225007704 ATP binding site [chemical binding]; other site 314225007705 Q-loop/lid; other site 314225007706 ABC transporter signature motif; other site 314225007707 Walker B; other site 314225007708 D-loop; other site 314225007709 H-loop/switch region; other site 314225007710 BON domain; Region: BON; pfam04972 314225007711 Mechanosensitive ion channel; Region: MS_channel; pfam00924 314225007712 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 314225007713 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 314225007714 dimer interface [polypeptide binding]; other site 314225007715 substrate binding site [chemical binding]; other site 314225007716 metal binding sites [ion binding]; metal-binding site 314225007717 histidyl-tRNA synthetase; Region: hisS; TIGR00442 314225007718 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 314225007719 dimer interface [polypeptide binding]; other site 314225007720 motif 1; other site 314225007721 active site 314225007722 motif 2; other site 314225007723 motif 3; other site 314225007724 peptide chain release factor 1; Validated; Region: prfA; PRK00591 314225007725 This domain is found in peptide chain release factors; Region: PCRF; smart00937 314225007726 RF-1 domain; Region: RF-1; pfam00472 314225007727 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 314225007728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 314225007729 S-adenosylmethionine binding site [chemical binding]; other site 314225007730 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 314225007731 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 314225007732 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 314225007733 putative active site [active] 314225007734 catalytic triad [active] 314225007735 putative dimer interface [polypeptide binding]; other site 314225007736 S-adenosylmethionine synthetase; Validated; Region: PRK05250 314225007737 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 314225007738 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 314225007739 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 314225007740 Predicted membrane protein [Function unknown]; Region: COG2311 314225007741 Protein of unknown function (DUF418); Region: DUF418; cl12135 314225007742 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 314225007743 CoA-transferase family III; Region: CoA_transf_3; pfam02515 314225007744 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 314225007745 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 314225007746 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 314225007747 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 314225007748 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 314225007749 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 314225007750 Cell division protein 48 (CDC48), domain 2; Region: CDC48_2; pfam02933 314225007751 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 314225007752 Walker A motif; other site 314225007753 ATP binding site [chemical binding]; other site 314225007754 Walker B motif; other site 314225007755 arginine finger; other site 314225007756 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 314225007757 Walker A motif; other site 314225007758 ATP binding site [chemical binding]; other site 314225007759 Walker B motif; other site 314225007760 arginine finger; other site 314225007761 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 314225007762 Mechanosensitive ion channel; Region: MS_channel; pfam00924 314225007763 DNA polymerase I; Provisional; Region: PRK05755 314225007764 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 314225007765 active site 314225007766 metal binding site 1 [ion binding]; metal-binding site 314225007767 putative 5' ssDNA interaction site; other site 314225007768 metal binding site 3; metal-binding site 314225007769 metal binding site 2 [ion binding]; metal-binding site 314225007770 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 314225007771 putative DNA binding site [nucleotide binding]; other site 314225007772 putative metal binding site [ion binding]; other site 314225007773 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 314225007774 active site 314225007775 catalytic site [active] 314225007776 substrate binding site [chemical binding]; other site 314225007777 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 314225007778 active site 314225007779 DNA binding site [nucleotide binding] 314225007780 catalytic site [active] 314225007781 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 314225007782 Protein required for attachment to host cells; Region: Host_attach; pfam10116 314225007783 Phosphotransferase enzyme family; Region: APH; pfam01636 314225007784 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 314225007785 putative active site [active] 314225007786 putative substrate binding site [chemical binding]; other site 314225007787 ATP binding site [chemical binding]; other site 314225007788 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 314225007789 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 314225007790 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 314225007791 active site 314225007792 Domain of unknown function (DUF305); Region: DUF305; pfam03713 314225007793 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 314225007794 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 314225007795 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 314225007796 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 314225007797 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 314225007798 Multicopper oxidase; Region: Cu-oxidase; pfam00394 314225007799 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 314225007800 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 314225007801 putative homodimer interface [polypeptide binding]; other site 314225007802 putative homotetramer interface [polypeptide binding]; other site 314225007803 putative allosteric switch controlling residues; other site 314225007804 putative metal binding site [ion binding]; other site 314225007805 putative homodimer-homodimer interface [polypeptide binding]; other site 314225007806 Domain of unknown function (DUF305); Region: DUF305; cl17794 314225007807 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 314225007808 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 314225007809 ring oligomerisation interface [polypeptide binding]; other site 314225007810 ATP/Mg binding site [chemical binding]; other site 314225007811 stacking interactions; other site 314225007812 hinge regions; other site 314225007813 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 314225007814 oligomerisation interface [polypeptide binding]; other site 314225007815 mobile loop; other site 314225007816 roof hairpin; other site 314225007817 Mechanosensitive ion channel; Region: MS_channel; pfam00924 314225007818 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 314225007819 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 314225007820 cation binding site [ion binding]; other site 314225007821 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 314225007822 core dimer interface [polypeptide binding]; other site 314225007823 peripheral dimer interface [polypeptide binding]; other site 314225007824 L10 interface [polypeptide binding]; other site 314225007825 L11 interface [polypeptide binding]; other site 314225007826 putative EF-Tu interaction site [polypeptide binding]; other site 314225007827 putative EF-G interaction site [polypeptide binding]; other site 314225007828 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 314225007829 23S rRNA interface [nucleotide binding]; other site 314225007830 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 314225007831 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 314225007832 non-specific DNA binding site [nucleotide binding]; other site 314225007833 salt bridge; other site 314225007834 sequence-specific DNA binding site [nucleotide binding]; other site 314225007835 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 314225007836 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 314225007837 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 314225007838 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 314225007839 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 314225007840 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 314225007841 RPB1 interaction site [polypeptide binding]; other site 314225007842 RNA polymerase Rpb2, domain 7; Region: RNA_pol_Rpb2_7; pfam04560 314225007843 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 314225007844 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 314225007845 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 314225007846 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 314225007847 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 314225007848 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 314225007849 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 314225007850 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 314225007851 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 314225007852 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 314225007853 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 314225007854 DNA binding site [nucleotide binding] 314225007855 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 314225007856 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 314225007857 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 314225007858 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 314225007859 active site 314225007860 KMSKS motif; other site 314225007861 pyruvate kinase; Provisional; Region: PRK06247 314225007862 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 314225007863 domain interfaces; other site 314225007864 active site 314225007865 Protein of unknown function (DUF1244); Region: DUF1244; pfam06844 314225007866 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 314225007867 short chain dehydrogenase; Provisional; Region: PRK06701 314225007868 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 314225007869 NAD(P) binding site [chemical binding]; other site 314225007870 active site 314225007871 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 314225007872 hypothetical protein; Validated; Region: PRK00110 314225007873 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 314225007874 active site 314225007875 putative DNA-binding cleft [nucleotide binding]; other site 314225007876 dimer interface [polypeptide binding]; other site 314225007877 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 314225007878 ArsC family; Region: ArsC; pfam03960 314225007879 putative catalytic residues [active] 314225007880 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 314225007881 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 314225007882 active site 314225007883 catalytic site [active] 314225007884 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 314225007885 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 314225007886 S-adenosylmethionine binding site [chemical binding]; other site 314225007887 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 314225007888 aspartate kinase; Reviewed; Region: PRK06635 314225007889 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 314225007890 putative nucleotide binding site [chemical binding]; other site 314225007891 putative catalytic residues [active] 314225007892 putative Mg ion binding site [ion binding]; other site 314225007893 putative aspartate binding site [chemical binding]; other site 314225007894 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 314225007895 putative allosteric regulatory site; other site 314225007896 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 314225007897 putative allosteric regulatory residue; other site 314225007898 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 314225007899 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 314225007900 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 314225007901 putative active site [active] 314225007902 putative substrate binding site [chemical binding]; other site 314225007903 putative cosubstrate binding site; other site 314225007904 catalytic site [active] 314225007905 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 314225007906 short chain dehydrogenase; Provisional; Region: PRK06949 314225007907 classical (c) SDRs; Region: SDR_c; cd05233 314225007908 NAD(P) binding site [chemical binding]; other site 314225007909 active site 314225007910 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 314225007911 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 314225007912 PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); Region: PQQ_ADH_II; cd10279 314225007913 Trp docking motif [polypeptide binding]; other site 314225007914 cytochrome domain interface [polypeptide binding]; other site 314225007915 active site 314225007916 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 314225007917 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 314225007918 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 314225007919 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 314225007920 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 314225007921 NADH(P)-binding; Region: NAD_binding_10; pfam13460 314225007922 putative NAD(P) binding site [chemical binding]; other site 314225007923 active site 314225007924 integrase; Provisional; Region: PRK09692 314225007925 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 314225007926 active site 314225007927 Int/Topo IB signature motif; other site 314225007928 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 314225007929 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 314225007930 Catalytic site; other site 314225007931 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 314225007932 N-acetyl-D-glucosamine binding site [chemical binding]; other site 314225007933 catalytic residue [active] 314225007934 Toprim domain; Region: Toprim_3; pfam13362 314225007935 Methyltransferase domain; Region: Methyltransf_26; pfam13659 314225007936 P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872 314225007937 Helicase_C-like; Region: Helicase_C_4; pfam13871 314225007938 ParB-like nuclease domain; Region: ParBc; pfam02195 314225007939 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 314225007940 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 314225007941 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 314225007942 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 314225007943 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 314225007944 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 314225007945 dimer interface [polypeptide binding]; other site 314225007946 ssDNA binding site [nucleotide binding]; other site 314225007947 tetramer (dimer of dimers) interface [polypeptide binding]; other site 314225007948 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 314225007949 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 314225007950 Walker A motif; other site 314225007951 ATP binding site [chemical binding]; other site 314225007952 Walker B motif; other site 314225007953 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 314225007954 AAA domain; Region: AAA_30; pfam13604 314225007955 Predicted transcriptional regulator [Transcription]; Region: COG2932 314225007956 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 314225007957 Catalytic site [active] 314225007958 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 314225007959 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 314225007960 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 314225007961 Walker A/P-loop; other site 314225007962 ATP binding site [chemical binding]; other site 314225007963 AAA domain; Region: AAA_21; pfam13304 314225007964 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 314225007965 Walker B; other site 314225007966 D-loop; other site 314225007967 H-loop/switch region; other site 314225007968 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 314225007969 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 314225007970 TIGR02687 family protein; Region: TIGR02687 314225007971 PglZ domain; Region: PglZ; pfam08665 314225007972 Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337 314225007973 MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and Trafficking molecules) domains, as well as in some bacterial proteins. The function of this domain is unknown; Region: MIT_C; cd02685 314225007974 Protein of unknown function DUF91; Region: DUF91; cl00709 314225007975 Domain of unknown function (DUF4268); Region: DUF4268; pfam14088 314225007976 HipA N-terminal domain; Region: Couple_hipA; pfam13657 314225007977 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 314225007978 HipA-like N-terminal domain; Region: HipA_N; pfam07805 314225007979 HipA-like C-terminal domain; Region: HipA_C; pfam07804 314225007980 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 314225007981 Conjugative relaxosome accessory transposon protein; Region: TraH; pfam06122 314225007982 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 314225007983 F plasmid transfer operon protein; Region: TraF; pfam13728 314225007984 conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355 314225007985 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 314225007986 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673 314225007987 TraU protein; Region: TraU; pfam06834 314225007988 Sex factor F TraW protein N terminal; Region: TraW_N; cl10149 314225007989 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 314225007990 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 314225007991 type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746 314225007992 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 314225007993 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 314225007994 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 314225007995 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 314225007996 dimerization domain [polypeptide binding]; other site 314225007997 dimer interface [polypeptide binding]; other site 314225007998 catalytic residues [active] 314225007999 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 314225008000 TraK protein; Region: TraK; pfam06586 314225008001 TraE protein; Region: TraE; pfam05309 314225008002 TraL protein; Region: TraL; pfam07178 314225008003 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 314225008004 Transposase; Region: HTH_Tnp_1; pfam01527 314225008005 putative transposase OrfB; Reviewed; Region: PHA02517 314225008006 HTH-like domain; Region: HTH_21; pfam13276 314225008007 Integrase core domain; Region: rve; pfam00665 314225008008 Integrase core domain; Region: rve_3; pfam13683 314225008009 ABC1 family; Region: ABC1; cl17513 314225008010 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 314225008011 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 314225008012 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 314225008013 dimerization interface [polypeptide binding]; other site 314225008014 putative Zn2+ binding site [ion binding]; other site 314225008015 putative DNA binding site [nucleotide binding]; other site 314225008016 MarR family; Region: MarR_2; cl17246 314225008017 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 314225008018 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 314225008019 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 314225008020 CoenzymeA binding site [chemical binding]; other site 314225008021 subunit interaction site [polypeptide binding]; other site 314225008022 PHB binding site; other site 314225008023 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 314225008024 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 314225008025 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 314225008026 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 314225008027 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 314225008028 active site 314225008029 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 314225008030 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 314225008031 active site 314225008032 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 314225008033 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 314225008034 catalytic loop [active] 314225008035 iron binding site [ion binding]; other site 314225008036 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 314225008037 Cytochrome P450; Region: p450; cl12078 314225008038 Transcriptional regulators [Transcription]; Region: FadR; COG2186 314225008039 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 314225008040 DNA-binding site [nucleotide binding]; DNA binding site 314225008041 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 314225008042 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 314225008043 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 314225008044 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 314225008045 FMN binding site [chemical binding]; other site 314225008046 substrate binding site [chemical binding]; other site 314225008047 putative catalytic residue [active] 314225008048 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 314225008049 lipid-transfer protein; Provisional; Region: PRK07855 314225008050 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 314225008051 active site 314225008052 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 314225008053 DUF35 OB-fold domain; Region: DUF35; pfam01796 314225008054 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 314225008055 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 314225008056 active site 314225008057 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 314225008058 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 314225008059 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 314225008060 active site 314225008061 acyl-CoA synthetase; Validated; Region: PRK07798 314225008062 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 314225008063 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 314225008064 acyl-activating enzyme (AAE) consensus motif; other site 314225008065 acyl-activating enzyme (AAE) consensus motif; other site 314225008066 putative active site [active] 314225008067 putative AMP binding site [chemical binding]; other site 314225008068 putative CoA binding site [chemical binding]; other site 314225008069 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 314225008070 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 314225008071 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 314225008072 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 314225008073 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 314225008074 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 314225008075 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 314225008076 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 314225008077 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 314225008078 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 314225008079 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 314225008080 putative substrate translocation pore; other site 314225008081 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 314225008082 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 314225008083 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 314225008084 HlyD family secretion protein; Region: HlyD_3; pfam13437 314225008085 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 314225008086 mce related protein; Region: MCE; pfam02470 314225008087 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 314225008088 Catalytic domain of Protein Kinases; Region: PKc; cd00180 314225008089 active site 314225008090 ATP binding site [chemical binding]; other site 314225008091 substrate binding site [chemical binding]; other site 314225008092 activation loop (A-loop); other site 314225008093 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 314225008094 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 314225008095 DNA binding residues [nucleotide binding] 314225008096 Autotransporter beta-domain; Region: Autotransporter; pfam03797 314225008097 Autotransporter beta-domain; Region: Autotransporter; pfam03797