-- dump date 20140619_075141 -- class Genbank::misc_feature -- table misc_feature_note -- id note 716540000001 FMN-binding protein MioC; Provisional; Region: PRK09004 716540000002 HMMPfam hit to PF00258, Flavodoxin, score 9.2e-36 716540000003 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 716540000004 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 716540000005 putative DNA binding site [nucleotide binding]; other site 716540000006 putative Zn2+ binding site [ion binding]; other site 716540000007 AsnC family; Region: AsnC_trans_reg; pfam01037 716540000008 HMMPfam hit to PF01037, AsnC family, score 1e-19 716540000009 PS00519 Bacterial regulatory proteins, asnC family signature. 716540000010 Predicted helix-turn-helix motif with score 1631.000, SD 4.74 at aa 24-45, sequence TAYAELAKQFNVSPGTIHVRVE 716540000011 5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344 716540000012 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 716540000013 Methyltransferase domain; Region: Methyltransf_23; pfam13489 716540000014 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716540000015 S-adenosylmethionine binding site [chemical binding]; other site 716540000016 HMMPfam hit to PF08241, Methyltransferase domain, score 9.7e-10 716540000017 HMMPfam hit to PF08242, Methyltransferase domain, score 3e-14 716540000018 HMMPfam hit to PF03781, Domain of unknown function (DUF323), score 6.1e-12 716540000019 PS00017 ATP/GTP-binding site motif A (P-loop). 716540000020 hypothetical protein; Provisional; Region: yieM; PRK10997 716540000021 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 716540000022 metal ion-dependent adhesion site (MIDAS); other site 716540000023 regulatory ATPase RavA; Provisional; Region: PRK13531 716540000024 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716540000025 Walker A motif; other site 716540000026 ATP binding site [chemical binding]; other site 716540000027 Walker B motif; other site 716540000028 arginine finger; other site 716540000029 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 716540000030 HMMPfam hit to PF07728, ATPase family associated with various cellul, score 1.8e-41 716540000031 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 716540000032 potassium uptake protein; Region: kup; TIGR00794 716540000033 Signal peptide predicted for EAM_0006 by SignalP 2.0 HMM (Signal peptide probability 0.979) with cleavage site probability 0.977 between residues 22 and 23 716540000034 12 transmembrane helices predicted for EAM_0006 by TMHMM2.0 at aa 7-29, 49-71, 100-119, 134-156, 168-190, 210-232, 245-267, 287-309, 334-356, 366-388, 395-417 and 422-440 716540000035 HMMPfam hit to PF02705, K+ potassium transporter, score 4.6e-298 716540000036 PS00017 ATP/GTP-binding site motif A (P-loop). 716540000037 PS01159 WW/rsp5/WWP domain signature. 716540000038 PS00141 Eukaryotic and viral aspartyl proteases active site. 716540000039 PS01159 WW/rsp5/WWP domain signature. 716540000040 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 716540000041 HMMPfam hit to PF04076, Domain unknown function (DUF388), score 1.8e-51 716540000042 Signal peptide predicted for EAM_0010 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.990 between residues 20 and 21 716540000043 HMMPfam hit to PF01336, OB-fold nucleic acid binding domain, score 0.055 716540000044 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716540000045 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716540000046 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 716540000047 putative dimerization interface [polypeptide binding]; other site 716540000048 putative substrate binding pocket [chemical binding]; other site 716540000049 HMMPfam hit to PF03466, LysR substrate binding domain, score 2.4e-38 716540000050 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 5.6e-23 716540000051 PS00044 Bacterial regulatory proteins, lysR family signature. 716540000052 Predicted helix-turn-helix motif with score 1936.000, SD 5.78 at aa 16-37, sequence RHFTRAAEMLGISQPPLSQQIK 716540000053 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 716540000054 HMMPfam hit to PF03306, Alpha-acetolactate decarboxylase, score 1.8e-129 716540000055 acetolactate synthase; Reviewed; Region: PRK08617 716540000056 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 716540000057 PYR/PP interface [polypeptide binding]; other site 716540000058 dimer interface [polypeptide binding]; other site 716540000059 TPP binding site [chemical binding]; other site 716540000060 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 716540000061 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 716540000062 TPP-binding site [chemical binding]; other site 716540000063 HMMPfam hit to PF02776, Thiamine pyrophosphate enzyme, N-termina, score 2.9e-74 716540000064 HMMPfam hit to PF00205, Thiamine pyrophosphate enzyme, central d, score 2.1e-46 716540000065 HMMPfam hit to PF02775, Thiamine pyrophosphate enzyme, C-termina, score 3.1e-51 716540000066 PS00187 Thiamine pyrophosphate enzymes signature. 716540000067 D-ribose pyranase; Provisional; Region: PRK11797 716540000068 HMMPfam hit to PF05025, RbsD / FucU transport protein family, score 4.9e-72 716540000069 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 716540000070 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 716540000071 Walker A/P-loop; other site 716540000072 ATP binding site [chemical binding]; other site 716540000073 Q-loop/lid; other site 716540000074 ABC transporter signature motif; other site 716540000075 Walker B; other site 716540000076 D-loop; other site 716540000077 H-loop/switch region; other site 716540000078 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 716540000079 HMMPfam hit to PF00005, ABC transporter, score 1.6e-42 716540000080 PS00017 ATP/GTP-binding site motif A (P-loop). 716540000081 HMMPfam hit to PF00005, ABC transporter, score 3.6e-29 716540000082 PS00211 ABC transporters family signature. 716540000083 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 716540000084 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 716540000085 TM-ABC transporter signature motif; other site 716540000086 Signal peptide predicted for EAM_0017 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.556 between residues 42 and 43 716540000087 7 transmembrane helices predicted for EAM_0017 by TMHMM2.0 at aa 22-44, 65-87, 97-119, 126-148, 168-190, 221-243 and 275-297 716540000088 HMMPfam hit to PF02653, Branched-chain amino acid transport syst, score 5e-73 716540000089 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 716540000090 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 716540000091 ligand binding site [chemical binding]; other site 716540000092 dimerization interface [polypeptide binding]; other site 716540000093 Signal peptide predicted for EAM_0018 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 23 and 24 716540000094 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 4.5e-13 716540000095 PS00017 ATP/GTP-binding site motif A (P-loop). 716540000096 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 716540000097 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 716540000098 substrate binding site [chemical binding]; other site 716540000099 dimer interface [polypeptide binding]; other site 716540000100 ATP binding site [chemical binding]; other site 716540000101 HMMPfam hit to PF00294, pfkB family carbohydrate kinase, score 2.6e-90 716540000102 PS00583 pfkB family of carbohydrate kinases signature 1. 716540000103 HMMPfam hit to PF08543, Phosphomethylpyrimidine kinase, score 6.1e-05 716540000104 PS00584 pfkB family of carbohydrate kinases signature 2. 716540000105 transcriptional repressor RbsR; Provisional; Region: PRK10423 716540000106 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 716540000107 DNA binding site [nucleotide binding] 716540000108 domain linker motif; other site 716540000109 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 716540000110 dimerization interface [polypeptide binding]; other site 716540000111 ligand binding site [chemical binding]; other site 716540000112 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 3.5e-13 716540000113 Predicted helix-turn-helix motif with score 2162.000, SD 6.55 at aa 2-23, sequence ATMKDVARLAGVSTSTVSYVIN 716540000114 PS00356 Bacterial regulatory proteins, lacI family signature. 716540000115 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 2.6e-17 716540000116 putative transporter; Provisional; Region: PRK10504 716540000117 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540000118 putative substrate translocation pore; other site 716540000119 14 transmembrane helices predicted for EAM_0021 by TMHMM2.0 at aa 13-35, 45-67, 80-102, 106-124, 133-155, 160-182, 195-217, 221-243, 263-285, 290-312, 324-346, 351-373, 394-416 and 426-448 716540000120 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 8.1e-47 716540000121 Signal peptide predicted for EAM_0021 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.641 between residues 23 and 24 716540000122 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 716540000123 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 716540000124 GTP binding site; other site 716540000125 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 716540000126 HMMPfam hit to PF06288, Protein of unknown function (DUF1040), score 2.6e-36 716540000127 serine/threonine protein kinase; Provisional; Region: PRK11768 716540000128 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 716540000129 HMMPfam hit to PF01636, Phosphotransferase enzyme family, score 5.6e-39 716540000130 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 716540000131 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 716540000132 catalytic residues [active] 716540000133 hinge region; other site 716540000134 alpha helical domain; other site 716540000135 Signal peptide predicted for EAM_0025 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.986 between residues 19 and 20 716540000136 HMMPfam hit to PF01323, DSBA-like thioredoxin domain, score 6e-43 716540000137 PS00194 Thioredoxin family active site. 716540000138 DNA polymerase I; Provisional; Region: PRK05755 716540000139 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 716540000140 active site 716540000141 metal binding site 1 [ion binding]; metal-binding site 716540000142 putative 5' ssDNA interaction site; other site 716540000143 metal binding site 3; metal-binding site 716540000144 metal binding site 2 [ion binding]; metal-binding site 716540000145 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 716540000146 putative DNA binding site [nucleotide binding]; other site 716540000147 putative metal binding site [ion binding]; other site 716540000148 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 716540000149 active site 716540000150 catalytic site [active] 716540000151 substrate binding site [chemical binding]; other site 716540000152 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 716540000153 active site 716540000154 DNA binding site [nucleotide binding] 716540000155 catalytic site [active] 716540000156 HMMPfam hit to PF02739, 5'-3' exonuclease, N-terminal resolvase-, score 9.6e-93 716540000157 HMMPfam hit to PF01367, 5'-3' exonuclease, C-terminal SAM fold, score 1.1e-49 716540000158 HMMPfam hit to PF01612, 3'-5' exonuclease, score 2.1e-56 716540000159 HMMPfam hit to PF00476, DNA polymerase family A, score 9.5e-209 716540000160 PS00447 DNA polymerase family A signature. 716540000161 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 716540000162 G1 box; other site 716540000163 GTP/Mg2+ binding site [chemical binding]; other site 716540000164 Switch I region; other site 716540000165 G2 box; other site 716540000166 G3 box; other site 716540000167 Switch II region; other site 716540000168 G4 box; other site 716540000169 G5 box; other site 716540000170 HMMPfam hit to PF01926, GTPase of unknown function, score 3.4e-26 716540000171 PS00017 ATP/GTP-binding site motif A (P-loop). 716540000172 Der GTPase activator; Provisional; Region: PRK05244 716540000173 HMMPfam hit to PF04220, Protein of unknown function, DUF414, score 3.7e-54 716540000174 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 716540000175 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 716540000176 FeS/SAM binding site; other site 716540000177 HemN C-terminal domain; Region: HemN_C; pfam06969 716540000178 HMMPfam hit to PF04055, Radical SAM superfamily, score 4.5e-22 716540000179 HMMPfam hit to PF06969, HemN C-terminal region, score 6.5e-53 716540000180 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 716540000181 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716540000182 active site 716540000183 phosphorylation site [posttranslational modification] 716540000184 intermolecular recognition site; other site 716540000185 dimerization interface [polypeptide binding]; other site 716540000186 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716540000187 Walker A motif; other site 716540000188 ATP binding site [chemical binding]; other site 716540000189 Walker B motif; other site 716540000190 arginine finger; other site 716540000191 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 716540000192 HMMPfam hit to PF02954, Bacterial regulatory protein, Fis fam, score 3.6e-16 716540000193 Predicted helix-turn-helix motif with score 1763.000, SD 5.19 at aa 443-464, sequence GHKQEAARLLGWGRNTLTRKLK 716540000194 HMMPfam hit to PF00158, Sigma-54 interaction domain, score 2.6e-144 716540000195 HMMPfam hit to PF07728, ATPase family associated with various, score 0.0004 716540000196 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 716540000197 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 716540000198 HMMPfam hit to PF00072, Response regulator receiver domain, score 6e-41 716540000199 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 716540000200 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 716540000201 dimer interface [polypeptide binding]; other site 716540000202 phosphorylation site [posttranslational modification] 716540000203 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716540000204 ATP binding site [chemical binding]; other site 716540000205 Mg2+ binding site [ion binding]; other site 716540000206 G-X-G motif; other site 716540000207 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 5.4e-28 716540000208 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 3.8e-15 716540000209 glutamine synthetase; Provisional; Region: glnA; PRK09469 716540000210 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 716540000211 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 716540000212 PS00182 Glutamine synthetase class-I adenylation site. 716540000213 HMMPfam hit to PF00120, Glutamine synthetase, catalytic domain, score 9.5e-176 716540000214 PS00181 Glutamine synthetase ATP-binding region signature. 716540000215 HMMPfam hit to PF03951, Glutamine synthetase, beta-Grasp domain, score 4.7e-49 716540000216 PS00180 Glutamine synthetase signature 1. 716540000217 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 716540000218 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 716540000219 G1 box; other site 716540000220 putative GEF interaction site [polypeptide binding]; other site 716540000221 GTP/Mg2+ binding site [chemical binding]; other site 716540000222 Switch I region; other site 716540000223 G2 box; other site 716540000224 G3 box; other site 716540000225 Switch II region; other site 716540000226 G4 box; other site 716540000227 G5 box; other site 716540000228 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 716540000229 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 716540000230 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 2.4e-74 716540000231 PS00017 ATP/GTP-binding site motif A (P-loop). 716540000232 PS00301 GTP-binding elongation factors signature. 716540000233 HMMPfam hit to PF03144, Elongation factor Tu domain, score 3.5e-14 716540000234 HMMPfam hit to PF00679, Elongation factor G C-terminus, score 3.9e-20 716540000235 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 716540000236 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716540000237 motif II; other site 716540000238 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 8.4e-18 716540000239 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 716540000240 hypothetical protein; Reviewed; Region: PRK01637 716540000241 HMMPfam hit to PF03631, Ribonuclease BN-like family, score 2.8e-67 716540000242 6 transmembrane helices predicted for EAM_0035 by TMHMM2.0 at aa 37-59, 96-118, 138-160, 175-197, 210-232 and 242-264 716540000243 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 716540000244 putative active site [active] 716540000245 dimerization interface [polypeptide binding]; other site 716540000246 putative tRNAtyr binding site [nucleotide binding]; other site 716540000247 HMMPfam hit to PF02580, D-Tyr-tRNA(Tyr) deacylase, score 1.2e-75 716540000248 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 716540000249 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716540000250 Coenzyme A binding pocket [chemical binding]; other site 716540000251 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 716540000252 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 2.8e-14 716540000253 Predicted helix-turn-helix motif with score 1005.000, SD 2.61 at aa 91-112, sequence MTLESVARQEGVKRVVCSARED 716540000254 1 transmembrane helix predicted for EAM_0037 by TMHMM2.0 at aa 202-224 716540000255 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 716540000256 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 716540000257 RNA binding surface [nucleotide binding]; other site 716540000258 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 716540000259 probable active site [active] 716540000260 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 1.4e-26 716540000261 PS01149 Rsu family of pseudouridine synthase signature. 716540000262 HMMPfam hit to PF01479, S4 domain, score 3.1e-10 716540000263 AsmA family; Region: AsmA; pfam05170 716540000264 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 716540000265 HMMPfam hit to PF05170, AsmA family, score 1.6e-131 716540000266 PS00340 Growth factor and cytokines receptors family signature 2. 716540000267 1 transmembrane helix predicted for EAM_0039 by TMHMM2.0 at aa 7-29 716540000268 Signal peptide predicted for EAM_0039 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.271 between residues 21 and 22 716540000269 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 716540000270 10 transmembrane helices predicted for EAM_0040 by TMHMM2.0 at aa 43-65, 127-149, 156-178, 193-212, 219-241, 261-283, 346-368, 378-400, 407-429 and 439-458 716540000271 HMMPfam hit to PF00860, Permease family, score 1.4e-154 716540000272 PS01116 Xanthine/uracil permeases family signature. 716540000273 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 716540000274 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 716540000275 generic binding surface II; other site 716540000276 ssDNA binding site; other site 716540000277 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 716540000278 ATP binding site [chemical binding]; other site 716540000279 putative Mg++ binding site [ion binding]; other site 716540000280 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 716540000281 nucleotide binding region [chemical binding]; other site 716540000282 ATP-binding site [chemical binding]; other site 716540000283 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 9.1e-23 716540000284 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 1.8e-32 716540000285 PS00017 ATP/GTP-binding site motif A (P-loop). 716540000286 HMMPfam hit to PF01336, OB-fold nucleic acid binding domain, score 1.6e-12 716540000287 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 716540000288 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 716540000289 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 716540000290 HMMPfam hit to PF00588, SpoU rRNA Methylase family, score 7.3e-51 716540000291 PS00196 Type-1 copper (blue) proteins signature. 716540000292 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 716540000293 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 716540000294 Zn2+ binding site [ion binding]; other site 716540000295 Mg2+ binding site [ion binding]; other site 716540000296 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 716540000297 synthetase active site [active] 716540000298 NTP binding site [chemical binding]; other site 716540000299 metal binding site [ion binding]; metal-binding site 716540000300 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 716540000301 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 716540000302 HMMPfam hit to PF02824, TGS domain, score 3.6e-27 716540000303 HMMPfam hit to PF04607, Region found in RelA / SpoT proteins, score 2.1e-46 716540000304 HMMPfam hit to PF01966, HD domain, score 2e-19 716540000305 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 716540000306 HMMPfam hit to PF01192, RNA polymerase Rpb6, score 2e-23 716540000307 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 716540000308 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 716540000309 catalytic site [active] 716540000310 G-X2-G-X-G-K; other site 716540000311 HMMPfam hit to PF00625, Guanylate kinase, score 3.1e-59 716540000312 PS00856 Guanylate kinase signature. 716540000313 PS00017 ATP/GTP-binding site motif A (P-loop). 716540000314 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 716540000315 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 716540000316 nucleotide binding pocket [chemical binding]; other site 716540000317 K-X-D-G motif; other site 716540000318 catalytic site [active] 716540000319 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 716540000320 Signal peptide predicted for EAM_0046 by SignalP 2.0 HMM (Signal peptide probability 0.840) with cleavage site probability 0.756 between residues 17 and 18 716540000321 HMMPfam hit to PF01653, NAD-dependent DNA ligase adenylation, score 1.2e-47 716540000322 PS01055 NAD-dependent DNA ligase signature 1. 716540000323 HMMPfam hit to PF03120, NAD-dependent DNA ligase OB-fold doma, score 1.3e-11 716540000324 PS01056 NAD-dependent DNA ligase signature 2. 716540000325 Predicted membrane protein [Function unknown]; Region: COG2860 716540000326 UPF0126 domain; Region: UPF0126; pfam03458 716540000327 UPF0126 domain; Region: UPF0126; pfam03458 716540000328 7 transmembrane helices predicted for EAM_0047 by TMHMM2.0 at aa 4-23, 30-49, 64-81, 88-107, 111-133, 140-162 and 167-189 716540000329 HMMPfam hit to PF03458, UPF0126 domain, score 2e-35 716540000330 HMMPfam hit to PF03458, UPF0126 domain, score 4.3e-38 716540000331 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 716540000332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716540000333 active site 716540000334 phosphorylation site [posttranslational modification] 716540000335 intermolecular recognition site; other site 716540000336 dimerization interface [polypeptide binding]; other site 716540000337 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 716540000338 DNA binding residues [nucleotide binding] 716540000339 dimerization interface [polypeptide binding]; other site 716540000340 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.6e-08 716540000341 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR fami, score 5.7e-15 716540000342 Predicted helix-turn-helix motif with score 1248.000, SD 3.44 at aa 169-190, sequence YTLSEIARRQNRTISTVSTQKY 716540000343 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540000344 Major Facilitator Superfamily; Region: MFS_1; pfam07690 716540000345 putative substrate translocation pore; other site 716540000346 12 transmembrane helices predicted for EAM_0049 by TMHMM2.0 at aa 7-29, 44-66, 73-92, 97-119, 131-153, 158-177, 203-225, 235-257, 264-283, 288-310, 323-345 and 355-374 716540000347 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 8.5e-31 716540000348 Signal peptide predicted for EAM_0049 by SignalP 2.0 HMM (Signal peptide probability 0.769) with cleavage site probability 0.257 between residues 38 and 39 716540000349 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 716540000350 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 716540000351 PhnA protein; Region: PhnA; pfam03831 716540000352 HMMPfam hit to PF03831, PhnA protein, score 3.6e-36 716540000353 HMMPfam hit to PF08274, PhnA Zinc-Ribbon, score 1.5e-11 716540000354 2 transmembrane helices predicted for EAM_0053 by TMHMM2.0 at aa 7-29 and 68-90 716540000355 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 716540000356 possible degenerate mobile element 716540000357 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 716540000358 Transposase; Region: HTH_Tnp_1; pfam01527 716540000359 HMMPfam hit to PF01527, Transposase, score 2.2e-16 716540000360 Predicted helix-turn-helix motif with score 1288.000, SD 3.57 at aa 26-47, sequence YTVAAAATAMNVGKSTMDKWVR 716540000361 1 transmembrane helix predicted for EAM_0056 by TMHMM2.0 at aa 111-133 716540000362 HTH-like domain; Region: HTH_21; pfam13276 716540000363 Integrase core domain; Region: rve; pfam00665 716540000364 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 716540000365 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 716540000366 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 716540000367 cofactor binding site; other site 716540000368 DNA binding site [nucleotide binding] 716540000369 substrate interaction site [chemical binding]; other site 716540000370 HMMPfam hit to PF00145, C-5 cytosine-specific DNA methylase, score 3.5e-80 716540000371 PS00094 C-5 cytosine-specific DNA methylases active site. 716540000372 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. 716540000373 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 716540000374 Walker A motif; other site 716540000375 ATP binding site [chemical binding]; other site 716540000376 Walker B motif; other site 716540000377 arginine finger; other site 716540000378 HMMPfam hit to PF07728, ATPase family associated with various cellul, score 1.2e-12 716540000379 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 716540000380 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 716540000381 active site 716540000382 Int/Topo IB signature motif; other site 716540000383 HMMPfam hit to PF00589, Phage integrase family, score 3.8e-06 716540000384 hypothetical protein; Provisional; Region: PRK11820 716540000385 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 716540000386 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 716540000387 HMMPfam hit to PF08340, Domain of unknown function (DUF1732), score 4.3e-57 716540000388 HMMPfam hit to PF03755, YicC-like family, N-terminal region, score 2.7e-79 716540000389 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 716540000390 Signal peptide predicted for EAM_0065 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.309 between residues 24 and 25 716540000391 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540000392 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 716540000393 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 716540000394 Nucleoside recognition; Region: Gate; pfam07670 716540000395 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 716540000396 HMMPfam hit to PF07662, Na+ dependent nucleoside transporter C, score 9.8e-95 716540000397 8 transmembrane helices predicted for EAM_0066 by TMHMM2.0 at aa 4-23, 32-54, 86-108, 193-212, 248-270, 282-304, 336-358 and 371-393 716540000398 HMMPfam hit to PF07670, Nucleoside recognition, score 3e-13 716540000399 HMMPfam hit to PF01773, Na+ dependent nucleoside transporter N, score 5.9e-21 716540000400 Signal peptide predicted for EAM_0066 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.425 between residues 23 and 24 716540000401 ribonuclease PH; Reviewed; Region: rph; PRK00173 716540000402 Ribonuclease PH; Region: RNase_PH_bact; cd11362 716540000403 hexamer interface [polypeptide binding]; other site 716540000404 active site 716540000405 HMMPfam hit to PF01138, 3' exoribonuclease family, domain, score 1.6e-55 716540000406 PS01277 Ribonuclease PH signature. 716540000407 HMMPfam hit to PF03725, 3' exoribonuclease family, domain, score 5.5e-23 716540000408 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 716540000409 active site 716540000410 HMMPfam hit to PF00156, Phosphoribosyl transferase domain, score 8.1e-29 716540000411 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 716540000412 division inhibitor protein; Provisional; Region: slmA; PRK09480 716540000413 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 716540000414 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 7e-10 716540000415 PS01081 Bacterial regulatory proteins, tetR family signature. 716540000416 Predicted helix-turn-helix motif with score 1937.000, SD 5.78 at aa 32-53, sequence ITTAKLAASVGVSEAALYRHFP 716540000417 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 716540000418 trimer interface [polypeptide binding]; other site 716540000419 active site 716540000420 HMMPfam hit to PF00692, dUTPase, score 3.2e-52 716540000421 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 716540000422 Flavoprotein; Region: Flavoprotein; pfam02441 716540000423 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 716540000424 HMMPfam hit to PF04127, DNA / pantothenate metabolism flavoprote, score 1.2e-35 716540000425 HMMPfam hit to PF02441, Flavoprotein, score 4.6e-50 716540000426 hypothetical protein; Reviewed; Region: PRK00024 716540000427 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 716540000428 MPN+ (JAMM) motif; other site 716540000429 Zinc-binding site [ion binding]; other site 716540000430 HMMPfam hit to PF04002, RadC, DNA repair protein, score 2.1e-70 716540000431 PS01302 DNA repair protein radC family signature. 716540000432 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 716540000433 HMMPfam hit to PF00830, Ribosomal L28 family, score 7.8e-37 716540000434 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 716540000435 HMMPfam hit to PF00471, Ribosomal protein L33, score 1.5e-24 716540000436 PS00582 Ribosomal protein L33 signature. 716540000437 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 716540000438 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 716540000439 DNA binding site [nucleotide binding] 716540000440 catalytic residue [active] 716540000441 H2TH interface [polypeptide binding]; other site 716540000442 putative catalytic residues [active] 716540000443 turnover-facilitating residue; other site 716540000444 intercalation triad [nucleotide binding]; other site 716540000445 8OG recognition residue [nucleotide binding]; other site 716540000446 putative reading head residues; other site 716540000447 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 716540000448 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 716540000449 HMMPfam hit to PF01149, Formamidopyrimidine-DNA glycosylase N-, score 4.4e-58 716540000450 HMMPfam hit to PF06831, Formamidopyrimidine-DNA glycosylase H2, score 2e-45 716540000451 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 716540000452 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 716540000453 active site 716540000454 (T/H)XGH motif; other site 716540000455 HMMPfam hit to PF01467, Cytidylyltransferase, score 1e-34 716540000456 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 716540000457 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 716540000458 putative metal binding site; other site 716540000459 HMMPfam hit to PF00535, Glycosyl transferase family, score 4.3e-17 716540000460 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 716540000461 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 716540000462 Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534 716540000463 HMMPfam hit to PF00534, Glycosyl transferases group, score 7e-05 716540000464 HMMPfam hit to PF04413, 3-Deoxy-D-manno-octulosonic-acid tran, score 4.8e-102 716540000465 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 716540000466 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 716540000467 putative active site [active] 716540000468 HMMPfam hit to PF01075, Glycosyltransferase family, score 9.3e-10 716540000469 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 716540000470 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 716540000471 putative ADP-binding pocket [chemical binding]; other site 716540000472 HMMPfam hit to PF00534, Glycosyl transferases group, score 2e-25 716540000473 PS00017 ATP/GTP-binding site motif A (P-loop). 716540000474 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 716540000475 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 716540000476 HMMPfam hit to PF00534, Glycosyl transferases group, score 4.9e-29 716540000477 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 716540000478 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 716540000479 putative active site [active] 716540000480 HMMPfam hit to PF01075, Glycosyltransferase family, score 2e-49 716540000481 Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935 716540000482 putative active site [active] 716540000483 putative catalytic site [active] 716540000484 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 716540000485 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 716540000486 putative active site [active] 716540000487 HMMPfam hit to PF01075, Glycosyltransferase family, score 3.7e-09 716540000488 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 716540000489 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 716540000490 active site 716540000491 HMMPfam hit to PF00535, Glycosyl transferase family, score 5.9e-32 716540000492 10 transmembrane helices predicted for EAM_0086 by TMHMM2.0 at aa 9-26, 36-55, 62-81, 91-113, 122-144, 159-178, 185-207, 231-248, 338-360 and 380-402 716540000493 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 716540000494 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 716540000495 HMMPfam hit to PF00534, Glycosyl transferases group, score 8.8e-13 716540000496 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 716540000497 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 716540000498 putative active site [active] 716540000499 HMMPfam hit to PF01075, Glycosyltransferase family, score 4.4e-91 716540000500 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 716540000501 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 716540000502 putative active site [active] 716540000503 HMMPfam hit to PF01075, Glycosyltransferase family, score 6.4e-109 716540000504 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 716540000505 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 716540000506 NADP binding site [chemical binding]; other site 716540000507 homopentamer interface [polypeptide binding]; other site 716540000508 substrate binding site [chemical binding]; other site 716540000509 active site 716540000510 HMMPfam hit to PF04321, RmlD substrate binding domain, score 0.001 716540000511 HMMPfam hit to PF01073, 3-beta hydroxysteroid dehydrogenase/iso, score 3e-06 716540000512 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase fam, score 6.2e-51 716540000513 HMMPfam hit to PF07993, Male sterility protein, score 0.0022 716540000514 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 716540000515 NodB motif; other site 716540000516 putative active site [active] 716540000517 putative catalytic site [active] 716540000518 Zn binding site [ion binding]; other site 716540000519 HMMPfam hit to PF04748, Divergent polysaccharide deacetylase, score 6.1e-107 716540000520 Signal peptide predicted for EAM_0091 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.964 between residues 22 and 23 716540000521 AmiB activator; Provisional; Region: PRK11637 716540000522 Peptidase family M23; Region: Peptidase_M23; pfam01551 716540000523 HMMPfam hit to PF01551, Peptidase family M23, score 6.3e-41 716540000524 1 transmembrane helix predicted for EAM_0092 by TMHMM2.0 at aa 21-43 716540000525 Signal peptide predicted for EAM_0092 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 42 and 43 716540000526 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 716540000527 active site residue [active] 716540000528 1 transmembrane helix predicted for EAM_0093 by TMHMM2.0 at aa 7-29 716540000529 HMMPfam hit to PF00581, Rhodanese-like domain, score 3.5e-14 716540000530 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 716540000531 GSH binding site [chemical binding]; other site 716540000532 catalytic residues [active] 716540000533 HMMPfam hit to PF00462, Glutaredoxin, score 5.7e-28 716540000534 PS00195 Glutaredoxin active site. 716540000535 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 716540000536 SecA binding site; other site 716540000537 Preprotein binding site; other site 716540000538 HMMPfam hit to PF02556, Preprotein translocase subunit SecB, score 5.2e-93 716540000539 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 716540000540 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 716540000541 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 716540000542 Signal peptide predicted for EAM_0096 by SignalP 2.0 HMM (Signal peptide probability 0.974) with cleavage site probability 0.943 between residues 21 and 22 716540000543 HMMPfam hit to PF01210, NAD-dependent glycerol-3-phosphate deh, score 1.6e-73 716540000544 HMMPfam hit to PF02558, Ketopantoate reductase PanE/ApbA, score 0.00039 716540000545 HMMPfam hit to PF07479, NAD-dependent glycerol-3-phosphate deh, score 2.6e-78 716540000546 PS00957 NAD-dependent glycerol-3-phosphate dehydrogenase signature. 716540000547 serine acetyltransferase; Provisional; Region: cysE; PRK11132 716540000548 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 716540000549 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 716540000550 trimer interface [polypeptide binding]; other site 716540000551 active site 716540000552 substrate binding site [chemical binding]; other site 716540000553 CoA binding site [chemical binding]; other site 716540000554 HMMPfam hit to PF06426, Serine acetyltransferase, N-terminal, score 3.2e-61 716540000555 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.8 716540000556 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 9.7 716540000557 PS00101 Hexapeptide-repeat containing-transferases signature. 716540000558 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 2.1 716540000559 putative rRNA methylase; Provisional; Region: PRK10358 716540000560 HMMPfam hit to PF00588, SpoU rRNA Methylase family, score 4.2e-39 716540000561 two-component sensor protein; Provisional; Region: cpxA; PRK09470 716540000562 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 716540000563 dimerization interface [polypeptide binding]; other site 716540000564 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 716540000565 dimer interface [polypeptide binding]; other site 716540000566 phosphorylation site [posttranslational modification] 716540000567 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716540000568 ATP binding site [chemical binding]; other site 716540000569 Mg2+ binding site [ion binding]; other site 716540000570 G-X-G motif; other site 716540000571 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 3.9e-37 716540000572 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 1.1e-17 716540000573 HMMPfam hit to PF00672, HAMP domain, score 3.6e-14 716540000574 2 transmembrane helices predicted for EAM_0099 by TMHMM2.0 at aa 5-27 and 165-187 716540000575 Signal peptide predicted for EAM_0099 by SignalP 2.0 HMM (Signal peptide probability 0.850) with cleavage site probability 0.365 between residues 26 and 27 716540000576 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 716540000577 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716540000578 active site 716540000579 phosphorylation site [posttranslational modification] 716540000580 intermolecular recognition site; other site 716540000581 dimerization interface [polypeptide binding]; other site 716540000582 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 716540000583 DNA binding site [nucleotide binding] 716540000584 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 7e-23 716540000585 HMMPfam hit to PF00072, Response regulator receiver domain, score 3.1e-40 716540000586 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 716540000587 dimer interface [polypeptide binding]; other site 716540000588 Signal peptide predicted for EAM_0101 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.566 between residues 25 and 26 716540000589 1 transmembrane helix predicted for EAM_0101 by TMHMM2.0 at aa 7-29 716540000590 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 716540000591 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 716540000592 Signal peptide predicted for EAM_0102 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.952 between residues 41 and 42 716540000593 6 transmembrane helices predicted for EAM_0102 by TMHMM2.0 at aa 12-34, 38-60, 80-102, 117-139, 158-175 and 180-199 716540000594 HMMPfam hit to PF01545, Cation efflux family, score 9.8e-100 716540000595 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 716540000596 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 716540000597 active site 716540000598 ADP/pyrophosphate binding site [chemical binding]; other site 716540000599 dimerization interface [polypeptide binding]; other site 716540000600 allosteric effector site; other site 716540000601 fructose-1,6-bisphosphate binding site; other site 716540000602 HMMPfam hit to PF00365, Phosphofructokinase, score 1.2e-181 716540000603 PS00433 Phosphofructokinase signature. 716540000604 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 716540000605 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 716540000606 membrane-bound complex binding site; other site 716540000607 hinge residues; other site 716540000608 Signal peptide predicted for EAM_0104 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 19 and 20 716540000609 HMMPfam hit to PF01547, Bacterial extracellular solute-binding prot, score 1.2e-10 716540000610 PS00757 Prokaryotic sulfate-binding proteins signature 2. 716540000611 CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471 716540000612 HMMPfam hit to PF02611, CDP-diacylglycerol pyrophosphatase, score 2e-76 716540000613 1 transmembrane helix predicted for EAM_0105 by TMHMM2.0 at aa 7-29 716540000614 inner membrane protein YhjD; Region: TIGR00766 716540000615 HMMPfam hit to PF03631, Ribonuclease BN-like family, score 2e-27 716540000616 6 transmembrane helices predicted for EAM_0106 by TMHMM2.0 at aa 74-96, 133-155, 185-207, 227-249, 261-283 and 298-320 716540000617 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 716540000618 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 716540000619 HMMPfam hit to PF02567, Phenazine biosynthesis-like protein, score 6.6e-64 716540000620 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 716540000621 malate:quinone oxidoreductase; Validated; Region: PRK05257 716540000622 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 716540000623 HMMPfam hit to PF06039, Malate:quinone oxidoreductase (Mqo), score 0 716540000624 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 3.8e-05 716540000625 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 716540000626 triosephosphate isomerase; Provisional; Region: PRK14567 716540000627 substrate binding site [chemical binding]; other site 716540000628 dimer interface [polypeptide binding]; other site 716540000629 catalytic triad [active] 716540000630 HMMPfam hit to PF00121, Triosephosphate isomerase, score 1.1e-136 716540000631 PS00171 Triosephosphate isomerase active site. 716540000632 PS00017 ATP/GTP-binding site motif A (P-loop). 716540000633 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 716540000634 HMMPfam hit to PF07305, Protein of unknown function (DUF1454), score 1.3e-99 716540000635 Signal peptide predicted for EAM_0112 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.737 between residues 22 and 23 716540000636 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540000637 Predicted membrane protein [Function unknown]; Region: COG3152 716540000638 Signal peptide predicted for EAM_0113 by SignalP 2.0 HMM (Signal peptide probability 0.944) with cleavage site probability 0.595 between residues 42 and 43 716540000639 HMMPfam hit to PF05656, Protein of unknown function (DUF805), score 1.2e-32 716540000640 4 transmembrane helices predicted for EAM_0113 by TMHMM2.0 at aa 20-42, 46-63, 75-94 and 99-121 716540000641 ferredoxin-NADP reductase; Provisional; Region: PRK10926 716540000642 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 716540000643 FAD binding pocket [chemical binding]; other site 716540000644 FAD binding motif [chemical binding]; other site 716540000645 phosphate binding motif [ion binding]; other site 716540000646 beta-alpha-beta structure motif; other site 716540000647 NAD binding pocket [chemical binding]; other site 716540000648 HMMPfam hit to PF00175, Oxidoreductase NAD-binding domain, score 1.3e-18 716540000649 HMMPfam hit to PF00970, Oxidoreductase FAD-binding domain, score 1.5e-06 716540000650 PS00430 TonB-dependent receptor proteins signature 1. 716540000651 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 716540000652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540000653 putative substrate translocation pore; other site 716540000654 Signal peptide predicted for EAM_0115 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.844 between residues 23 and 24 716540000655 10 transmembrane helices predicted for EAM_0115 by TMHMM2.0 at aa 9-31, 69-91, 98-120, 135-157, 164-183, 212-234, 241-263, 273-295, 302-324 and 362-384 716540000656 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.8e-42 716540000657 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 716540000658 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 716540000659 putative active site [active] 716540000660 HMMPfam hit to PF03320, Bacterial fructose-1,6-bisphosphatase, gl, score 2.3e-225 716540000661 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 716540000662 Signal peptide predicted for EAM_0117 by SignalP 2.0 HMM (Signal peptide probability 0.875) with cleavage site probability 0.808 between residues 45 and 46 716540000663 9 transmembrane helices predicted for EAM_0117 by TMHMM2.0 at aa 21-38, 43-65, 78-100, 106-128, 135-157, 172-194, 206-228, 238-260 and 281-303 716540000664 HMMPfam hit to PF01758, Sodium Bile acid symporter family, score 0.0014 716540000665 glycerol kinase; Provisional; Region: glpK; PRK00047 716540000666 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 716540000667 N- and C-terminal domain interface [polypeptide binding]; other site 716540000668 active site 716540000669 MgATP binding site [chemical binding]; other site 716540000670 catalytic site [active] 716540000671 metal binding site [ion binding]; metal-binding site 716540000672 glycerol binding site [chemical binding]; other site 716540000673 homotetramer interface [polypeptide binding]; other site 716540000674 homodimer interface [polypeptide binding]; other site 716540000675 FBP binding site [chemical binding]; other site 716540000676 protein IIAGlc interface [polypeptide binding]; other site 716540000677 HMMPfam hit to PF02782, FGGY family of carbohydrate kinases, C-termi, score 2.6e-102 716540000678 PS00445 FGGY family of carbohydrate kinases signature 2. 716540000679 HMMPfam hit to PF00370, FGGY family of carbohydrate kinases, N-termi, score 3.2e-128 716540000680 PS00933 FGGY family of carbohydrate kinases signature 1. 716540000681 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 716540000682 amphipathic channel; other site 716540000683 Asn-Pro-Ala signature motifs; other site 716540000684 6 transmembrane helices predicted for EAM_0119 by TMHMM2.0 at aa 13-35, 45-67, 87-109, 144-166, 179-201 and 234-256 716540000685 HMMPfam hit to PF00230, Major intrinsic protein, score 2.9e-96 716540000686 PS00221 MIP family signature. 716540000687 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540000688 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3074 716540000689 HMMPfam hit to PF06005, Protein of unknown function (DUF904), score 3.6e-42 716540000690 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 716540000691 HMMPfam hit to PF03737, Demethylmenaquinone methyltransferase, score 7.1e-74 716540000692 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 716540000693 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716540000694 Walker A motif; other site 716540000695 ATP binding site [chemical binding]; other site 716540000696 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 716540000697 Walker B motif; other site 716540000698 arginine finger; other site 716540000699 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 716540000700 HMMPfam hit to PF07724, ATPase family associated with various cellul, score 1.8e-55 716540000701 PS00017 ATP/GTP-binding site motif A (P-loop). 716540000702 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 716540000703 active site 716540000704 HslU subunit interaction site [polypeptide binding]; other site 716540000705 HMMPfam hit to PF00227, Proteasome A-type and B-type, score 7.7e-35 716540000706 essential cell division protein FtsN; Provisional; Region: PRK10927 716540000707 cell division protein FtsN; Provisional; Region: PRK12757 716540000708 HMMPfam hit to PF05036, Sporulation related domain, score 7.1e-18 716540000709 1 transmembrane helix predicted for EAM_0124 by TMHMM2.0 at aa 33-55 716540000710 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 716540000711 DNA binding site [nucleotide binding] 716540000712 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 716540000713 domain linker motif; other site 716540000714 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 716540000715 dimerization interface [polypeptide binding]; other site 716540000716 ligand binding site [chemical binding]; other site 716540000717 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 1.1e-16 716540000718 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 7.6e-12 716540000719 Predicted helix-turn-helix motif with score 1739.000, SD 5.11 at aa 10-31, sequence ATMKDVANKAGVSTATVSRALM 716540000720 PS00356 Bacterial regulatory proteins, lacI family signature. 716540000721 primosome assembly protein PriA; Validated; Region: PRK05580 716540000722 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 716540000723 ATP binding site [chemical binding]; other site 716540000724 putative Mg++ binding site [ion binding]; other site 716540000725 helicase superfamily c-terminal domain; Region: HELICc; smart00490 716540000726 nucleotide binding region [chemical binding]; other site 716540000727 ATP-binding site [chemical binding]; other site 716540000728 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 0.00047 716540000729 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 4.2e-28 716540000730 HMMPfam hit to PF04851, Type III restriction enzyme, res subunit, score 4.8e-08 716540000731 PS00017 ATP/GTP-binding site motif A (P-loop). 716540000732 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 716540000733 HMMPfam hit to PF01197, Ribosomal protein L31, score 4.5e-43 716540000734 PS00190 Cytochrome c family heme-binding site signature. 716540000735 PS01143 Ribosomal protein L31 signature. 716540000736 unique vs ECA 716540000737 Signal peptide predicted for EAM_0129 by SignalP 2.0 HMM (Signal peptide probability 0.968) with cleavage site probability 0.896 between residues 45 and 46 716540000738 1 transmembrane helix predicted for EAM_0129 by TMHMM2.0 at aa 12-34 716540000739 1 transmembrane helix predicted for EAM_0131 by TMHMM2.0 at aa 7-26 716540000740 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540000741 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 716540000742 dimerization interface [polypeptide binding]; other site 716540000743 DNA binding site [nucleotide binding] 716540000744 corepressor binding sites; other site 716540000745 HMMPfam hit to PF01340, Met Apo-repressor, MetJ, score 1.2e-84 716540000746 cystathionine gamma-synthase; Provisional; Region: PRK08045 716540000747 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 716540000748 homodimer interface [polypeptide binding]; other site 716540000749 substrate-cofactor binding pocket; other site 716540000750 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716540000751 catalytic residue [active] 716540000752 HMMPfam hit to PF01053, Cys/Met metabolism PLP-dependent enzy, score 1.8e-203 716540000753 PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. 716540000754 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 716540000755 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 716540000756 putative catalytic residues [active] 716540000757 putative nucleotide binding site [chemical binding]; other site 716540000758 putative aspartate binding site [chemical binding]; other site 716540000759 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 716540000760 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 716540000761 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 716540000762 HMMPfam hit to PF00696, Amino acid kinase family, score 3.8e-39 716540000763 PS00324 Aspartokinase signature. 716540000764 Predicted helix-turn-helix motif with score 1009.000, SD 2.62 at aa 213-234, sequence YSATQIGALAGVTRVTIWSDVA 716540000765 HMMPfam hit to PF03447, Homoserine dehydrogenase, NAD binding d, score 2.5e-36 716540000766 HMMPfam hit to PF00742, Homoserine dehydrogenase, score 3e-99 716540000767 PS01042 Homoserine dehydrogenase signature. 716540000768 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 716540000769 FAD binding site [chemical binding]; other site 716540000770 HMMPfam hit to PF02219, Methylenetetrahydrofolate reductase, score 2.5e-162 716540000771 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 716540000772 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 716540000773 HMMPfam hit to PF00311, Phosphoenolpyruvate carboxylase, score 1.5e-222 716540000774 PS00393 Phosphoenolpyruvate carboxylase active site 2. 716540000775 PS00781 Phosphoenolpyruvate carboxylase active site 1. 716540000776 acetylornithine deacetylase; Provisional; Region: PRK05111 716540000777 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 716540000778 metal binding site [ion binding]; metal-binding site 716540000779 putative dimer interface [polypeptide binding]; other site 716540000780 HMMPfam hit to PF01546, Peptidase family M20/M25/M40, score 1.3e-41 716540000781 HMMPfam hit to PF07687, Peptidase dimerisation domain, score 1e-32 716540000782 PS00759 ArgE / dapE / ACY1 / CPG2 / yscS family signature 2. 716540000783 PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 716540000784 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 716540000785 nucleotide binding site [chemical binding]; other site 716540000786 N-acetyl-L-glutamate binding site [chemical binding]; other site 716540000787 HMMPfam hit to PF00696, Amino acid kinase family, score 1.1e-41 716540000788 argininosuccinate synthase; Provisional; Region: PRK13820 716540000789 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 716540000790 ANP binding site [chemical binding]; other site 716540000791 Substrate Binding Site II [chemical binding]; other site 716540000792 Substrate Binding Site I [chemical binding]; other site 716540000793 HMMPfam hit to PF00764, Arginosuccinate synthase, score 1.6e-174 716540000794 PS00564 Argininosuccinate synthase signature 1. 716540000795 PS00565 Argininosuccinate synthase signature 2. 716540000796 argininosuccinate lyase; Provisional; Region: PRK04833 716540000797 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 716540000798 active sites [active] 716540000799 tetramer interface [polypeptide binding]; other site 716540000800 HMMPfam hit to PF00206, Lyase, score 3.8e-137 716540000801 PS00163 Fumarate lyases signature. 716540000802 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 716540000803 catalytic triad [active] 716540000804 dimer interface [polypeptide binding]; other site 716540000805 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 716540000806 HMMPfam hit to PF00462, Glutaredoxin, score 8.6e-22 716540000807 PS00195 Glutaredoxin active site. 716540000808 HMMPfam hit to PF08534, Redoxin, score 1.1e-39 716540000809 HMMPfam hit to PF00578, AhpC/TSA family, score 5.2e-05 716540000810 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 716540000811 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716540000812 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 716540000813 dimerization interface [polypeptide binding]; other site 716540000814 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 9.8e-22 716540000815 Predicted helix-turn-helix motif with score 1816.000, SD 5.37 at aa 16-37, sequence RHFRRAADACHVSQPTLSGQIR 716540000816 PS00044 Bacterial regulatory proteins, lysR family signature. 716540000817 HMMPfam hit to PF03466, LysR substrate binding domain, score 4.5e-58 716540000818 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 716540000819 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 716540000820 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 716540000821 HMMPfam hit to PF02852, Pyridine nucleotide-disulphide oxidored, score 4.4e-39 716540000822 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidored, score 5.2e-44 716540000823 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidored, score 3.5e-27 716540000824 Predicted helix-turn-helix motif with score 1019.000, SD 2.66 at aa 78-99, sequence LLRSSFADILKHTENVISQQTH 716540000825 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 716540000826 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 716540000827 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 1e-10 716540000828 Predicted helix-turn-helix motif with score 1615.000, SD 4.69 at aa 32-53, sequence LSLREVSREAGIAPTSFYRHFR 716540000829 hypothetical protein; Provisional; Region: PRK11056 716540000830 Signal peptide predicted for EAM_0145 by SignalP 2.0 HMM (Signal peptide probability 0.991) with cleavage site probability 0.947 between residues 27 and 28 716540000831 HMMPfam hit to PF07226, Protein of unknown function (DUF1422), score 1.9e-46 716540000832 3 transmembrane helices predicted for EAM_0145 by TMHMM2.0 at aa 13-44, 64-83 and 90-109 716540000833 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 716540000834 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716540000835 S-adenosylmethionine binding site [chemical binding]; other site 716540000836 HMMPfam hit to PF05958, tRNA (Uracil-5-)-methyltransferase, score 7.6e-270 716540000837 PS01231 RNA methyltransferase trmA family signature 2. 716540000838 PS01230 RNA methyltransferase trmA family signature 1. 716540000839 glutamate racemase; Provisional; Region: PRK00865 716540000840 HMMPfam hit to PF01177, Asp/Glu/Hydantoin racemase, score 1.3e-88 716540000841 PS00923 Aspartate and glutamate racemases signature 1. 716540000842 PS00924 Aspartate and glutamate racemases signature 2. 716540000843 transcriptional regulator HdfR; Provisional; Region: PRK03601 716540000844 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716540000845 LysR substrate binding domain; Region: LysR_substrate; pfam03466 716540000846 dimerization interface [polypeptide binding]; other site 716540000847 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.2e-11 716540000848 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 4.1e-20 716540000849 PS00044 Bacterial regulatory proteins, lysR family signature. 716540000850 Predicted helix-turn-helix motif with score 1427.000, SD 4.05 at aa 16-37, sequence RHFGRAAEALYLTQSAVSFRIR 716540000851 hypothetical protein; Provisional; Region: PRK11027 716540000852 HMMPfam hit to PF04219, Protein of unknown function, DUF, score 5.4e-50 716540000853 putative ATP-dependent protease; Provisional; Region: PRK09862 716540000854 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 716540000855 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716540000856 Walker A motif; other site 716540000857 ATP binding site [chemical binding]; other site 716540000858 Walker B motif; other site 716540000859 arginine finger; other site 716540000860 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 716540000861 Predicted helix-turn-helix motif with score 1158.000, SD 3.13 at aa 445-466, sequence EWLERVMIQLGLSVRAWQRILK 716540000862 HMMPfam hit to PF01078, Magnesium chelatase, subunit ChlI, score 1.6e-137 716540000863 HMMPfam hit to PF07728, ATPase family associated with various ce, score 2.3e-05 716540000864 PS00017 ATP/GTP-binding site motif A (P-loop). 716540000865 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 716540000866 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 716540000867 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 716540000868 PYR/PP interface [polypeptide binding]; other site 716540000869 dimer interface [polypeptide binding]; other site 716540000870 TPP binding site [chemical binding]; other site 716540000871 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 716540000872 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 716540000873 TPP-binding site [chemical binding]; other site 716540000874 dimer interface [polypeptide binding]; other site 716540000875 HMMPfam hit to PF02776, Thiamine pyrophosphate enzyme, N-termina, score 5.3e-101 716540000876 PS00044 Bacterial regulatory proteins, lysR family signature. 716540000877 HMMPfam hit to PF00205, Thiamine pyrophosphate enzyme, central d, score 1.5e-60 716540000878 HMMPfam hit to PF02775, Thiamine pyrophosphate enzyme, C-termina, score 7.6e-73 716540000879 PS00187 Thiamine pyrophosphate enzymes signature. 716540000880 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 716540000881 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 716540000882 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 716540000883 homodimer interface [polypeptide binding]; other site 716540000884 substrate-cofactor binding pocket; other site 716540000885 catalytic residue [active] 716540000886 HMMPfam hit to PF01063, Aminotransferase class IV, score 2.3e-136 716540000887 PS00770 Aminotransferases class-IV signature. 716540000888 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 716540000889 HMMPfam hit to PF00920, Dehydratase family, score 0 716540000890 PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1. 716540000891 PS00017 ATP/GTP-binding site motif A (P-loop). 716540000892 PS00887 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 2. 716540000893 threonine dehydratase; Reviewed; Region: PRK09224 716540000894 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 716540000895 tetramer interface [polypeptide binding]; other site 716540000896 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716540000897 catalytic residue [active] 716540000898 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 716540000899 putative Ile/Val binding site [chemical binding]; other site 716540000900 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 716540000901 putative Ile/Val binding site [chemical binding]; other site 716540000902 HMMPfam hit to PF00291, Pyridoxal-phosphate dependent enzyme, score 6.1e-98 716540000903 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 716540000904 HMMPfam hit to PF00585, C-terminal regulatory domain of Threon, score 7.5e-43 716540000905 HMMPfam hit to PF00585, C-terminal regulatory domain of Threon, score 4.1e-42 716540000906 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716540000907 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 716540000908 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 716540000909 putative dimerization interface [polypeptide binding]; other site 716540000910 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.7e-31 716540000911 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 2.7e-21 716540000912 PS00044 Bacterial regulatory proteins, lysR family signature. 716540000913 Predicted helix-turn-helix motif with score 1925.000, SD 5.74 at aa 16-37, sequence RHFGRSARAMHVSPSTLSRQIQ 716540000914 ketol-acid reductoisomerase; Validated; Region: PRK05225 716540000915 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 716540000916 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 716540000917 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 716540000918 HMMPfam hit to PF07991, Acetohydroxy acid isomeroreductase, catalyti, score 8.5e-85 716540000919 HMMPfam hit to PF01450, Acetohydroxy acid isomeroreductase, catalyti, score 2.1e-130 716540000920 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 716540000921 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 716540000922 HMMPfam hit to PF00639, PPIC-type PPIASE domain, score 4.8e-37 716540000923 PS01096 PpiC-type peptidyl-prolyl cis-trans isomerase signature. 716540000924 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 716540000925 Part of AAA domain; Region: AAA_19; pfam13245 716540000926 Family description; Region: UvrD_C_2; pfam13538 716540000927 HMMPfam hit to PF00580, UvrD/REP helicase, score 2.6e-220 716540000928 PS00017 ATP/GTP-binding site motif A (P-loop). 716540000929 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 716540000930 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 716540000931 HMMPfam hit to PF02541, Ppx/GppA phosphatase family, score 1.9e-122 716540000932 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 716540000933 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 716540000934 ATP binding site [chemical binding]; other site 716540000935 Mg++ binding site [ion binding]; other site 716540000936 motif III; other site 716540000937 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 716540000938 nucleotide binding region [chemical binding]; other site 716540000939 ATP-binding site [chemical binding]; other site 716540000940 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 9.8e-34 716540000941 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 6.6e-59 716540000942 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 716540000943 PS00017 ATP/GTP-binding site motif A (P-loop). 716540000944 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 716540000945 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 716540000946 catalytic residues [active] 716540000947 HMMPfam hit to PF00085, Thioredoxin, score 2.7e-52 716540000948 PS00194 Thioredoxin family active site. 716540000949 transcription termination factor Rho; Provisional; Region: rho; PRK09376 716540000950 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 716540000951 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 716540000952 RNA binding site [nucleotide binding]; other site 716540000953 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 716540000954 multimer interface [polypeptide binding]; other site 716540000955 Walker A motif; other site 716540000956 ATP binding site [chemical binding]; other site 716540000957 Walker B motif; other site 716540000958 HMMPfam hit to PF07498, Rho termination factor, N-terminal domai, score 2.8e-20 716540000959 HMMPfam hit to PF07497, Rho termination factor, RNA-binding doma, score 4.1e-58 716540000960 HMMPfam hit to PF08206, Ribonuclease B OB domain, score 0.00098 716540000961 PS00464 Ribosomal protein L22 signature. 716540000962 HMMPfam hit to PF00006, ATP synthase alpha/beta family, nucleoti, score 6.5e-76 716540000963 PS00017 ATP/GTP-binding site motif A (P-loop). 716540000964 LPS biosynthesis locus 716540000965 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 716540000966 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 716540000967 Mg++ binding site [ion binding]; other site 716540000968 putative catalytic motif [active] 716540000969 substrate binding site [chemical binding]; other site 716540000970 Signal peptide predicted for EAM_0164 by SignalP 2.0 HMM (Signal peptide probability 0.961) with cleavage site probability 0.430 between residues 27 and 28 716540000971 11 transmembrane helices predicted for EAM_0164 by TMHMM2.0 at aa 10-24, 45-65, 70-89, 105-127, 131-153, 160-179, 184-206, 213-232, 242-261, 294-316 and 321-338 716540000972 HMMPfam hit to PF00953, Glycosyl transferase family, score 1.2e-09 716540000973 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 716540000974 Chain length determinant protein; Region: Wzz; pfam02706 716540000975 HMMPfam hit to PF02706, Chain length determinant protein, score 0.00011 716540000976 2 transmembrane helices predicted for EAM_0165 by TMHMM2.0 at aa 20-42 and 318-337 716540000977 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 716540000978 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 716540000979 active site 716540000980 homodimer interface [polypeptide binding]; other site 716540000981 HMMPfam hit to PF02350, UDP-N-acetylglucosamine 2-epimerase, score 1.2e-189 716540000982 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 716540000983 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 716540000984 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 716540000985 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 716540000986 Signal peptide predicted for EAM_0167 by SignalP 2.0 HMM (Signal peptide probability 0.942) with cleavage site probability 0.701 between residues 23 and 24 716540000987 HMMPfam hit to PF03721, UDP-glucose/GDP-mannose dehydrogenase, score 7.9e-86 716540000988 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540000989 HMMPfam hit to PF00984, UDP-glucose/GDP-mannose dehydrogenase, score 2.9e-46 716540000990 HMMPfam hit to PF03720, UDP-glucose/GDP-mannose dehydrogenase, score 8.3e-21 716540000991 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 716540000992 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 716540000993 NAD binding site [chemical binding]; other site 716540000994 substrate binding site [chemical binding]; other site 716540000995 homodimer interface [polypeptide binding]; other site 716540000996 active site 716540000997 HMMPfam hit to PF00106, short chain dehydrogenase, score 1.8e-05 716540000998 HMMPfam hit to PF04321, RmlD substrate binding domain, score 7.6e-07 716540000999 HMMPfam hit to PF02719, Polysaccharide biosynthesis protein, score 1.4e-06 716540001000 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase f, score 7.7e-90 716540001001 HMMPfam hit to PF01073, 3-beta hydroxysteroid dehydrogenase/i, score 5.9e-08 716540001002 HMMPfam hit to PF07993, Male sterility protein, score 1.7e-08 716540001003 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 716540001004 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 716540001005 substrate binding site; other site 716540001006 tetramer interface; other site 716540001007 HMMPfam hit to PF00483, Nucleotidyl transferase, score 5e-107 716540001008 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716540001009 Coenzyme A binding pocket [chemical binding]; other site 716540001010 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 6.8e-15 716540001011 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 716540001012 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 716540001013 inhibitor-cofactor binding pocket; inhibition site 716540001014 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716540001015 catalytic residue [active] 716540001016 HMMPfam hit to PF00155, Aminotransferase class I and II, score 0.00011 716540001017 HMMPfam hit to PF01041, DegT/DnrJ/EryC1/StrS aminotransferase, score 2.2e-83 716540001018 HMMPfam hit to PF01212, Beta-eliminating lyase, score 0.0027 716540001019 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 716540001020 12 transmembrane helices predicted for EAM_0172 by TMHMM2.0 at aa 13-35, 45-67, 80-102, 117-139, 146-168, 173-195, 216-238, 264-283, 296-318, 333-355, 362-384 and 389-411 716540001021 4-alpha-L-fucosyltransferase; Provisional; Region: PRK02797 716540001022 HMMPfam hit to PF07429, 4-alpha-L-fucosyltransferase (Fuc4NAc, score 7e-176 716540001023 putative common antigen polymerase; Provisional; Region: PRK02975 716540001024 HMMPfam hit to PF06899, WzyE protein, score 0 716540001025 Signal peptide predicted for EAM_0174 by SignalP 2.0 HMM (Signal peptide probability 0.846) with cleavage site probability 0.616 between residues 60 and 61 716540001026 11 transmembrane helices predicted for EAM_0174 by TMHMM2.0 at aa 4-26, 38-60, 70-89, 110-132, 152-174, 181-200, 204-223, 225-244, 337-359, 380-397 and 407-429 716540001027 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540001028 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 716540001029 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 716540001030 HMMPfam hit to PF03808, Glycosyl transferase WecB/TagA/CpsF f, score 9.3e-80 716540001031 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 716540001032 HemY protein N-terminus; Region: HemY_N; pfam07219 716540001033 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 716540001034 TPR motif; other site 716540001035 binding surface 716540001036 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 2.5e-05 716540001037 PS00215 Mitochondrial energy transfer proteins signature. 716540001038 HMMPfam hit to PF07219, HemY protein N-terminus, score 2.9e-61 716540001039 2 transmembrane helices predicted for EAM_0177 by TMHMM2.0 at aa 5-27 and 40-62 716540001040 Signal peptide predicted for EAM_0177 by SignalP 2.0 HMM (Signal peptide probability 0.945) with cleavage site probability 0.315 between residues 23 and 24 716540001041 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 716540001042 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 716540001043 HMMPfam hit to PF04375, HemX, score 1.2e-151 716540001044 1 transmembrane helix predicted for EAM_0178 by TMHMM2.0 at aa 35-57 716540001045 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 716540001046 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 716540001047 active site 716540001048 HMMPfam hit to PF02602, Uroporphyrinogen-III synthase HemD, score 3e-40 716540001049 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 716540001050 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 716540001051 domain interfaces; other site 716540001052 active site 716540001053 HMMPfam hit to PF03900, Porphobilinogen deaminase, C-terminal, score 1.1e-33 716540001054 PS00533 Porphobilinogen deaminase cofactor-binding site. 716540001055 HMMPfam hit to PF01379, Porphobilinogen deaminase, dipyrometh, score 4.2e-133 716540001056 adenylate cyclase; Provisional; Region: cyaA; PRK09450 716540001057 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 716540001058 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 716540001059 HMMPfam hit to PF01295, Adenylate cyclase, class-I, score 0 716540001060 PS01092 Adenylate cyclases class-I signature 1. 716540001061 PS01093 Adenylate cyclases class-I signature 2. 716540001062 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 716540001063 Signal peptide predicted for EAM_0182 by SignalP 2.0 HMM (Signal peptide probability 0.663) with cleavage site probability 0.245 between residues 23 and 24 716540001064 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540001065 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 716540001066 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 716540001067 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 716540001068 HMMPfam hit to PF01678, Diaminopimelate epimerase, score 4.1e-51 716540001069 PS01326 Diaminopimelate epimerase signature. 716540001070 HMMPfam hit to PF01678, Diaminopimelate epimerase, score 3e-51 716540001071 hypothetical protein; Provisional; Region: PRK10963 716540001072 HMMPfam hit to PF04340, Protein of unknown function, DUF484, score 2.4e-91 716540001073 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 716540001074 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 716540001075 active site 716540001076 DNA binding site [nucleotide binding] 716540001077 Int/Topo IB signature motif; other site 716540001078 HMMPfam hit to PF02899, Phage integrase, N-terminal SAM-like, score 5.4e-27 716540001079 HMMPfam hit to PF00589, Phage integrase family, score 1.2e-55 716540001080 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 716540001081 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716540001082 motif II; other site 716540001083 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 1.5e-22 716540001084 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 716540001085 Part of AAA domain; Region: AAA_19; pfam13245 716540001086 Family description; Region: UvrD_C_2; pfam13538 716540001087 HMMPfam hit to PF00580, UvrD/REP helicase, score 3.6e-221 716540001088 PS00017 ATP/GTP-binding site motif A (P-loop). 716540001089 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 716540001090 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 716540001091 Cl binding site [ion binding]; other site 716540001092 oligomer interface [polypeptide binding]; other site 716540001093 HMMPfam hit to PF01544, CorA-like Mg2+ transporter protein, score 7.4e-88 716540001094 2 transmembrane helices predicted for EAM_0188 by TMHMM2.0 at aa 258-276 and 291-313 716540001095 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 716540001096 CoenzymeA binding site [chemical binding]; other site 716540001097 subunit interaction site [polypeptide binding]; other site 716540001098 PHB binding site; other site 716540001099 HMMPfam hit to PF03061, Thioesterase superfamily, score 6.7e-11 716540001100 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 716540001101 dimerization interface [polypeptide binding]; other site 716540001102 substrate binding site [chemical binding]; other site 716540001103 active site 716540001104 calcium binding site [ion binding]; other site 716540001105 Signal peptide predicted for EAM_0190 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 20 and 21 716540001106 HMMPfam hit to PF02253, Phospholipase A1, score 3e-154 716540001107 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 716540001108 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 716540001109 ATP binding site [chemical binding]; other site 716540001110 putative Mg++ binding site [ion binding]; other site 716540001111 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 716540001112 nucleotide binding region [chemical binding]; other site 716540001113 ATP-binding site [chemical binding]; other site 716540001114 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 716540001115 Helicase and RNase D C-terminal; Region: HRDC; smart00341 716540001116 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 4.4e-34 716540001117 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 1.1e-29 716540001118 HMMPfam hit to PF00570, HRDC domain, score 3.5e-32 716540001119 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 716540001120 5 transmembrane helices predicted for EAM_0192 by TMHMM2.0 at aa 7-29, 44-66, 115-137, 147-169 and 189-206 716540001121 HMMPfam hit to PF01810, LysE type translocator, score 4.1e-54 716540001122 Signal peptide predicted for EAM_0192 by SignalP 2.0 HMM (Signal peptide probability 0.848) with cleavage site probability 0.479 between residues 24 and 25 716540001123 lysophospholipase L2; Provisional; Region: PRK10749 716540001124 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 716540001125 HMMPfam hit to PF00561, alpha/beta hydrolase fold, score 1.2e-30 716540001126 putative hydrolase; Provisional; Region: PRK10976 716540001127 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716540001128 active site 716540001129 motif I; other site 716540001130 motif II; other site 716540001131 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 716540001132 HMMPfam hit to PF05116, Sucrose-6F-phosphate phosphohydrolase, score 8e-05 716540001133 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 3.4e-05 716540001134 PS01228 Hypothetical cof family signature 1. 716540001135 HMMPfam hit to PF08282, haloacid dehalogenase-like hydrolase, score 4.1e-69 716540001136 PS01229 Hypothetical cof family signature 2. 716540001137 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 716540001138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540001139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540001140 12 transmembrane helices predicted for EAM_0195 by TMHMM2.0 at aa 27-44, 64-86, 93-115, 119-141, 160-182, 187-206, 253-272, 292-311, 318-340, 350-372, 384-406 and 410-432 716540001141 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.4e-51 716540001142 PS00942 glpT family of transporters signature. 716540001143 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 716540001144 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 716540001145 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 716540001146 HMMPfam hit to PF07308, Protein of unknown function (DUF1456), score 1.4e-30 716540001147 HMMPfam hit to PF07308, Protein of unknown function (DUF1456), score 5.5e-34 716540001148 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 716540001149 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716540001150 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 716540001151 putative dimerization interface [polypeptide binding]; other site 716540001152 HMMPfam hit to PF03466, LysR substrate binding domain, score 3.2e-46 716540001153 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 4.4e-17 716540001154 PS00044 Bacterial regulatory proteins, lysR family signature. 716540001155 Predicted helix-turn-helix motif with score 1726.000, SD 5.07 at aa 17-38, sequence GSLAAAAAQLHQTQSALSHQFS 716540001156 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 716540001157 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 716540001158 THF binding site; other site 716540001159 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 716540001160 substrate binding site [chemical binding]; other site 716540001161 THF binding site; other site 716540001162 zinc-binding site [ion binding]; other site 716540001163 HMMPfam hit to PF08267, Cobalamin-independent synthase, N-termina, score 3.4e-199 716540001164 HMMPfam hit to PF01717, Cobalamin-independent synthase, Catalytic, score 7.1e-230 716540001165 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 716540001166 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 716540001167 HMMPfam hit to PF01738, Dienelactone hydrolase family, score 4e-98 716540001168 uridine phosphorylase; Provisional; Region: PRK11178 716540001169 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 716540001170 HMMPfam hit to PF01048, Phosphorylase family, score 5.6e-101 716540001171 PS01232 Purine and other phosphorylases family 1 signature. 716540001172 RmuC family; Region: RmuC; pfam02646 716540001173 Signal peptide predicted for EAM_0201 by SignalP 2.0 HMM (Signal peptide probability 0.917) with cleavage site probability 0.892 between residues 32 and 33 716540001174 1 transmembrane helix predicted for EAM_0201 by TMHMM2.0 at aa 5-24 716540001175 HMMPfam hit to PF02646, RmuC family, score 4.9e-146 716540001176 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 716540001177 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716540001178 S-adenosylmethionine binding site [chemical binding]; other site 716540001179 HMMPfam hit to PF01209, ubiE/COQ5 methyltransferase family, score 2.3e-158 716540001180 PS01183 ubiE/COQ5 methyltransferase family signature 1. 716540001181 HMMPfam hit to PF08241, Methyltransferase domain, score 1.2e-27 716540001182 HMMPfam hit to PF08242, Methyltransferase domain, score 1.8e-12 716540001183 PS01184 ubiE/COQ5 methyltransferase family signature 2. 716540001184 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 716540001185 SCP-2 sterol transfer family; Region: SCP2; pfam02036 716540001186 HMMPfam hit to PF06843, Protein of unknown function (DUF1243), score 1.4e-72 716540001187 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 716540001188 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 716540001189 HMMPfam hit to PF03109, ABC1 family, score 1e-52 716540001190 2 transmembrane helices predicted for EAM_0204 by TMHMM2.0 at aa 498-517 and 524-541 716540001191 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 716540001192 HMMPfam hit to PF02416, mttA/Hcf106 family, score 4.1e-13 716540001193 1 transmembrane helix predicted for EAM_0205 by TMHMM2.0 at aa 4-21 716540001194 sec-independent translocase; Provisional; Region: PRK01770 716540001195 1 transmembrane helix predicted for EAM_0206 by TMHMM2.0 at aa 4-21 716540001196 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 716540001197 HMMPfam hit to PF00902, Sec-independent protein translocase, score 5.5e-98 716540001198 6 transmembrane helices predicted for EAM_0207 by TMHMM2.0 at aa 20-42, 74-96, 116-138, 158-180, 193-212 and 216-238 716540001199 PS01218 Uncharacterized protein family UPF0032 signature. 716540001200 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 716540001201 active site 716540001202 HMMPfam hit to PF01026, TatD related DNase, score 2.2e-95 716540001203 PS01090 Uncharacterized protein family UPF0006 signature 2. 716540001204 PS01091 Uncharacterized protein family UPF0006 signature 3. 716540001205 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 716540001206 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 716540001207 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 716540001208 HMMPfam hit to PF02357, Transcription termination factor nusG, score 6.9e-25 716540001209 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 716540001210 HMMPfam hit to PF01977, 3-octaprenyl-4-hydroxybenzoate carboxy-lyase, score 1.4e-241 716540001211 FMN reductase; Validated; Region: fre; PRK08051 716540001212 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 716540001213 FAD binding pocket [chemical binding]; other site 716540001214 FAD binding motif [chemical binding]; other site 716540001215 phosphate binding motif [ion binding]; other site 716540001216 beta-alpha-beta structure motif; other site 716540001217 NAD binding pocket [chemical binding]; other site 716540001218 HMMPfam hit to PF00970, Oxidoreductase FAD-binding domain, score 5.8e-05 716540001219 HMMPfam hit to PF00175, Oxidoreductase NAD-binding domain, score 2.8e-31 716540001220 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 716540001221 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 716540001222 dimer interface [polypeptide binding]; other site 716540001223 active site 716540001224 HMMPfam hit to PF02803, Thiolase, C-terminal domain, score 4.3e-80 716540001225 PS00099 Thiolases active site. 716540001226 PS00737 Thiolases signature 2. 716540001227 HMMPfam hit to PF00108, Thiolase, N-terminal domain, score 9.3e-138 716540001228 PS00098 Thiolases acyl-enzyme intermediate signature. 716540001229 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 716540001230 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 716540001231 substrate binding site [chemical binding]; other site 716540001232 oxyanion hole (OAH) forming residues; other site 716540001233 trimer interface [polypeptide binding]; other site 716540001234 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 716540001235 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 716540001236 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 716540001237 HMMPfam hit to PF00725, 3-hydroxyacyl-CoA dehydrogenase, C-terminal, score 0.0008 716540001238 HMMPfam hit to PF00725, 3-hydroxyacyl-CoA dehydrogenase, C-terminal, score 1.6e-31 716540001239 PS00067 3-hydroxyacyl-CoA dehydrogenase signature. 716540001240 HMMPfam hit to PF02737, 3-hydroxyacyl-CoA dehydrogenase, NAD binding, score 4.5e-84 716540001241 HMMPfam hit to PF00378, Enoyl-CoA hydratase/isomerase family, score 2.2e-79 716540001242 PS00166 Enoyl-CoA hydratase/isomerase signature. 716540001243 proline dipeptidase; Provisional; Region: PRK13607 716540001244 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 716540001245 active site 716540001246 HMMPfam hit to PF00557, metallopeptidase family M24, score 7.8e-79 716540001247 PS00491 Aminopeptidase P and proline dipeptidase signature. 716540001248 hypothetical protein; Provisional; Region: PRK11568 716540001249 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 716540001250 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 716540001251 HMMPfam hit to PF01205, Uncharacterized protein family UPF0029, score 4.6e-59 716540001252 PS00910 Uncharacterized protein family UPF0029 signature. 716540001253 potassium transporter; Provisional; Region: PRK10750 716540001254 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 716540001255 Signal peptide predicted for EAM_0216 by SignalP 2.0 HMM (Signal peptide probability 0.824) with cleavage site probability 0.455 between residues 28 and 29 716540001256 11 transmembrane helices predicted for EAM_0216 by TMHMM2.0 at aa 9-31, 35-57, 69-91, 133-155, 185-207, 238-260, 273-295, 332-354, 396-418, 423-444 and 456-478 716540001257 HMMPfam hit to PF02386, Cation transport protein, score 3.4e-117 716540001258 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 716540001259 PS00201 Flavodoxin signature. 716540001260 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 716540001261 FAD binding domain; Region: FAD_binding_4; pfam01565 716540001262 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 716540001263 HMMPfam hit to PF01565, FAD binding domain, score 9.9e-16 716540001264 HMMPfam hit to PF02873, UDP-N-acetylenolpyruvoylglucosamine red, score 9.4e-60 716540001265 Biotin operon repressor [Transcription]; Region: BirA; COG1654 716540001266 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 716540001267 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 716540001268 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 716540001269 HMMPfam hit to PF08279, HTH domain, score 7.2e-11 716540001270 Predicted helix-turn-helix motif with score 1593.000, SD 4.61 at aa 20-41, sequence HSGEQLGEQMGMSRAAINKHVH 716540001271 HMMPfam hit to PF03099, Biotin/lipoate A/B protein ligase famil, score 1.7e-24 716540001272 HMMPfam hit to PF02237, Biotin protein ligase C terminal domain, score 4.4e-10 716540001273 pantothenate kinase; Provisional; Region: PRK05439 716540001274 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 716540001275 ATP-binding site [chemical binding]; other site 716540001276 CoA-binding site [chemical binding]; other site 716540001277 Mg2+-binding site [ion binding]; other site 716540001278 HMMPfam hit to PF00485, Phosphoribulokinase / Uridine kinase family, score 7.8e-07 716540001279 PS00017 ATP/GTP-binding site motif A (P-loop). 716540001280 elongation factor Tu; Reviewed; Region: PRK00049 716540001281 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 716540001282 G1 box; other site 716540001283 GEF interaction site [polypeptide binding]; other site 716540001284 GTP/Mg2+ binding site [chemical binding]; other site 716540001285 Switch I region; other site 716540001286 G2 box; other site 716540001287 G3 box; other site 716540001288 Switch II region; other site 716540001289 G4 box; other site 716540001290 G5 box; other site 716540001291 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 716540001292 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 716540001293 Antibiotic Binding Site [chemical binding]; other site 716540001294 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 4.8e-96 716540001295 PS00017 ATP/GTP-binding site motif A (P-loop). 716540001296 PS00301 GTP-binding elongation factors signature. 716540001297 HMMPfam hit to PF03144, Elongation factor Tu domain, score 1.6e-26 716540001298 HMMPfam hit to PF03143, Elongation factor Tu C-terminal domain, score 2.6e-60 716540001299 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 716540001300 3 transmembrane helices predicted for EAM_0222 by TMHMM2.0 at aa 21-41, 46-68 and 99-121 716540001301 HMMPfam hit to PF00584, SecE/Sec61-gamma subunits of protein translo, score 3.7e-26 716540001302 PS01067 Protein secE/sec61-gamma signature. 716540001303 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 716540001304 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 716540001305 putative homodimer interface [polypeptide binding]; other site 716540001306 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 716540001307 heterodimer interface [polypeptide binding]; other site 716540001308 homodimer interface [polypeptide binding]; other site 716540001309 HMMPfam hit to PF02357, Transcription termination factor nusG, score 5.9e-57 716540001310 HMMPfam hit to PF00467, KOW motif, score 1.5e-11 716540001311 PS01014 Transcription termination factor nusG signature. 716540001312 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 716540001313 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 716540001314 23S rRNA interface [nucleotide binding]; other site 716540001315 L7/L12 interface [polypeptide binding]; other site 716540001316 putative thiostrepton binding site; other site 716540001317 L25 interface [polypeptide binding]; other site 716540001318 HMMPfam hit to PF03946, Ribosomal protein L11, N-terminal dom, score 1.2e-38 716540001319 HMMPfam hit to PF00298, Ribosomal protein L11, RNA binding do, score 1.4e-38 716540001320 PS00359 Ribosomal protein L11 signature. 716540001321 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 716540001322 mRNA/rRNA interface [nucleotide binding]; other site 716540001323 HMMPfam hit to PF00687, Ribosomal protein L1p/L10e family, score 1.5e-135 716540001324 PS01199 Ribosomal protein L1 signature. 716540001325 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 716540001326 23S rRNA interface [nucleotide binding]; other site 716540001327 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 716540001328 HMMPfam hit to PF00466, Ribosomal protein L10, score 1.6e-36 716540001329 PS01109 Ribosomal protein L10 signature. 716540001330 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 716540001331 core dimer interface [polypeptide binding]; other site 716540001332 peripheral dimer interface [polypeptide binding]; other site 716540001333 L10 interface [polypeptide binding]; other site 716540001334 L11 interface [polypeptide binding]; other site 716540001335 putative EF-Tu interaction site [polypeptide binding]; other site 716540001336 putative EF-G interaction site [polypeptide binding]; other site 716540001337 HMMPfam hit to PF00542, Ribosomal protein L7/L12 C-terminal dom, score 7.3e-36 716540001338 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 716540001339 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 716540001340 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 716540001341 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 716540001342 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 716540001343 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 716540001344 RPB3 interaction site [polypeptide binding]; other site 716540001345 RPB1 interaction site [polypeptide binding]; other site 716540001346 RPB11 interaction site [polypeptide binding]; other site 716540001347 RPB10 interaction site [polypeptide binding]; other site 716540001348 HMMPfam hit to PF04563, RNA polymerase beta subunit, score 3e-35 716540001349 HMMPfam hit to PF04561, RNA polymerase Rpb2, domain, score 2.3e-06 716540001350 HMMPfam hit to PF04565, RNA polymerase Rpb2, domain, score 1.8e-43 716540001351 HMMPfam hit to PF00562, RNA polymerase Rpb2, domain, score 3.5e-187 716540001352 PS01166 RNA polymerases beta chain signature. 716540001353 HMMPfam hit to PF04560, RNA polymerase Rpb2, domain, score 4.1e-52 716540001354 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 716540001355 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 716540001356 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 716540001357 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 716540001358 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 716540001359 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 716540001360 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 716540001361 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 716540001362 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 716540001363 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 716540001364 DNA binding site [nucleotide binding] 716540001365 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 716540001366 HMMPfam hit to PF04997, RNA polymerase Rpb1, domain, score 3.4e-159 716540001367 HMMPfam hit to PF00623, RNA polymerase Rpb1, domain, score 2.9e-83 716540001368 HMMPfam hit to PF04983, RNA polymerase Rpb1, domain, score 7e-51 716540001369 HMMPfam hit to PF05000, RNA polymerase Rpb1, domain, score 4e-31 716540001370 HMMPfam hit to PF04998, RNA polymerase Rpb1, domain, score 3.7e-105 716540001371 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 716540001372 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 716540001373 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 716540001374 HMMPfam hit to PF00805, Pentapeptide repeats (8 copies), score 3.7e-08 716540001375 HMMPfam hit to PF00805, Pentapeptide repeats (8 copies), score 0.084 716540001376 Fimbrial operon 1. Unique vs ECA 716540001377 fimbrial protein PefA; Provisional; Region: PRK15214 716540001378 Signal peptide predicted for EAM_0231 by SignalP 2.0 HMM (Signal peptide probability 0.977) with cleavage site probability 0.586 between residues 20 and 21 716540001379 1 transmembrane helix predicted for EAM_0231 by TMHMM2.0 at aa 5-27 716540001380 fimbrial outer membrane usher protein PefC; Provisional; Region: PRK15213 716540001381 PapC N-terminal domain; Region: PapC_N; pfam13954 716540001382 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 716540001383 Signal peptide predicted for EAM_0232 by SignalP 2.0 HMM (Signal peptide probability 0.924) with cleavage site probability 0.866 between residues 35 and 36 716540001384 1 transmembrane helix predicted for EAM_0232 by TMHMM2.0 at aa 13-35 716540001385 HMMPfam hit to PF00577, Fimbrial Usher protein, score 2.5e-220 716540001386 PS00017 ATP/GTP-binding site motif A (P-loop). 716540001387 PS01151 Fimbrial biogenesis outer membrane usher protein signature. 716540001388 fimbrial chaperone protein PefD; Provisional; Region: PRK15211 716540001389 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 716540001390 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 716540001391 Signal peptide predicted for EAM_0233 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.729 between residues 37 and 38 716540001392 HMMPfam hit to PF00345, Gram-negative pili assembly chaperone, score 1e-55 716540001393 PS00635 Gram-negative pili assembly chaperone signature. 716540001394 HMMPfam hit to PF02753, Gram-negative pili assembly chaperone, score 2.1e-08 716540001395 Signal peptide predicted for EAM_0234 by SignalP 2.0 HMM (Signal peptide probability 0.985) with cleavage site probability 0.954 between residues 25 and 26 716540001396 1 transmembrane helix predicted for EAM_0234 by TMHMM2.0 at aa 5-24 716540001397 Fimbrial, major and minor subunit; Region: Fimbrial_K88; pfam02432 716540001398 Signal peptide predicted for EAM_0235 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.762 between residues 21 and 22 716540001399 HMMPfam hit to PF02432, Fimbrial, major and minor subunit, score 1.2e-27 716540001400 Fimbrial, major and minor subunit; Region: Fimbrial_K88; pfam02432 716540001401 Signal peptide predicted for EAM_0236 by SignalP 2.0 HMM (Signal peptide probability 0.981) with cleavage site probability 0.744 between residues 24 and 25 716540001402 HMMPfam hit to PF02432, Fimbrial, major and minor subunit, score 1.6e-80 716540001403 Fimbrial, major and minor subunit; Region: Fimbrial_K88; pfam02432 716540001404 Signal peptide predicted for EAM_0237 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.733 between residues 20 and 21 716540001405 HMMPfam hit to PF02432, Fimbrial, major and minor subunit, score 2.7e-74 716540001406 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 716540001407 outer membrane protease; Reviewed; Region: PRK10993 716540001408 HMMPfam hit to PF01278, Omptin family, score 6.5e-145 716540001409 PS00017 ATP/GTP-binding site motif A (P-loop). 716540001410 Signal peptide predicted for EAM_0238 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.795 between residues 20 and 21 716540001411 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 716540001412 thiamine phosphate binding site [chemical binding]; other site 716540001413 active site 716540001414 pyrophosphate binding site [ion binding]; other site 716540001415 HMMPfam hit to PF02581, Thiamine monophosphate synthase/TENI, score 2.1e-72 716540001416 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 716540001417 ThiC-associated domain; Region: ThiC-associated; pfam13667 716540001418 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 716540001419 HMMPfam hit to PF01964, ThiC family, score 0 716540001420 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 716540001421 HMMPfam hit to PF04353, Regulator of RNA polymerase sigma(70) subuni, score 9.3e-57 716540001422 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 716540001423 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 716540001424 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 716540001425 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 716540001426 putative NADH binding site [chemical binding]; other site 716540001427 putative active site [active] 716540001428 nudix motif; other site 716540001429 putative metal binding site [ion binding]; other site 716540001430 HMMPfam hit to PF00293, NUDIX domain, score 2e-24 716540001431 PS00893 mutT domain signature. 716540001432 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 716540001433 substrate binding site [chemical binding]; other site 716540001434 active site 716540001435 HMMPfam hit to PF01208, Uroporphyrinogen decarboxylase (URO-D), score 6.6e-206 716540001436 PS00906 Uroporphyrinogen decarboxylase signature 1. 716540001437 PS00907 Uroporphyrinogen decarboxylase signature 2. 716540001438 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 716540001439 Active_site [active] 716540001440 HMMPfam hit to PF04493, Endonuclease V, score 2e-91 716540001441 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 716540001442 HMMPfam hit to PF04222, Protein of unknown function, DUF, score 1.6e-149 716540001443 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 716540001444 IHF dimer interface [polypeptide binding]; other site 716540001445 IHF - DNA interface [nucleotide binding]; other site 716540001446 HMMPfam hit to PF00216, Bacterial DNA-binding protein, score 2e-49 716540001447 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 716540001448 HMMPfam hit to PF07356, Protein of unknown function (DUF1481), score 3.2e-68 716540001449 Signal peptide predicted for EAM_0247 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.836 between residues 26 and 27 716540001450 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540001451 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 716540001452 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 716540001453 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 716540001454 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 716540001455 HMMPfam hit to PF02843, Phosphoribosylglycinamide synthetase, C d, score 5.2e-49 716540001456 PS00184 Phosphoribosylglycinamide synthetase signature. 716540001457 HMMPfam hit to PF01071, Phosphoribosylglycinamide synthetase, ATP, score 4.5e-130 716540001458 HMMPfam hit to PF02655, ATP-grasp domain, score 0.0008 716540001459 HMMPfam hit to PF02844, Phosphoribosylglycinamide synthetase, N d, score 3.7e-61 716540001460 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 716540001461 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 716540001462 purine monophosphate binding site [chemical binding]; other site 716540001463 dimer interface [polypeptide binding]; other site 716540001464 putative catalytic residues [active] 716540001465 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 716540001466 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 716540001467 HMMPfam hit to PF01808, AICARFT/IMPCHase bienzyme, score 1.8e-216 716540001468 HMMPfam hit to PF02142, MGS-like domain, score 9.3e-64 716540001469 homoserine O-succinyltransferase; Provisional; Region: PRK05368 716540001470 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 716540001471 proposed active site lysine [active] 716540001472 conserved cys residue [active] 716540001473 HMMPfam hit to PF04204, Homoserine O-succinyltransferase, score 1.1e-200 716540001474 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 716540001475 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 716540001476 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 716540001477 PhoU domain; Region: PhoU; pfam01895 716540001478 8 transmembrane helices predicted for EAM_0252 by TMHMM2.0 at aa 4-26, 46-68, 99-121, 133-155, 175-197, 202-224, 239-261 and 274-296 716540001479 HMMPfam hit to PF02690, Na+/Pi-cotransporter, score 1.4e-57 716540001480 aspartate kinase III; Validated; Region: PRK09084 716540001481 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 716540001482 nucleotide binding site [chemical binding]; other site 716540001483 substrate binding site [chemical binding]; other site 716540001484 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 716540001485 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 716540001486 dimer interface [polypeptide binding]; other site 716540001487 HMMPfam hit to PF01842, ACT domain, score 0.00026 716540001488 HMMPfam hit to PF00696, Amino acid kinase family, score 3.9e-59 716540001489 PS00237 G-protein coupled receptors signature. 716540001490 PS00324 Aspartokinase signature. 716540001491 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 716540001492 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 716540001493 active site 716540001494 dimer interface [polypeptide binding]; other site 716540001495 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 716540001496 dimer interface [polypeptide binding]; other site 716540001497 active site 716540001498 HMMPfam hit to PF00342, Phosphoglucose isomerase, score 0 716540001499 PS00765 Phosphoglucose isomerase signature 1. 716540001500 PS00174 Phosphoglucose isomerase signature 2. 716540001501 Signal peptide predicted for EAM_0255 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 22 and 23 716540001502 2 transmembrane helices predicted for EAM_0255 by TMHMM2.0 at aa 5-27 and 42-64 716540001503 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 716540001504 Signal peptide predicted for EAM_0256 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.695 between residues 15 and 16 716540001505 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540001506 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 716540001507 Signal peptide predicted for EAM_0257 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.987 between residues 21 and 22 716540001508 HMMPfam hit to PF06251, Protein of unknown function (DUF1017), score 1.5e-65 716540001509 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 716540001510 Signal peptide predicted for EAM_0258 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.898 between residues 22 and 23 716540001511 HMMPfam hit to PF06082, Bacterial lipoprotein (DUF940), score 0 716540001512 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540001513 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 716540001514 HMMPfam hit to PF06146, Phosphate-starvation-inducible E, score 2.9e-57 716540001515 4 transmembrane helices predicted for EAM_0259 by TMHMM2.0 at aa 13-35, 57-79, 86-105 and 115-132 716540001516 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540001517 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 716540001518 HMMPfam hit to PF04345, Chorismate lyase, score 4e-27 716540001519 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 716540001520 UbiA prenyltransferase family; Region: UbiA; pfam01040 716540001521 7 transmembrane helices predicted for EAM_0261 by TMHMM2.0 at aa 21-43, 48-70, 98-120, 140-162, 167-189, 229-251 and 264-286 716540001522 HMMPfam hit to PF01040, UbiA prenyltransferase family, score 1.4e-77 716540001523 PS00943 UbiA prenyltransferase family signature. 716540001524 PS00217 Sugar transport proteins signature 2. 716540001525 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 716540001526 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 716540001527 putative acyl-acceptor binding pocket; other site 716540001528 PS00626 Regulator of chromosome condensation (RCC1) signature 2. 716540001529 HMMPfam hit to PF01553, Acyltransferase, score 4.8e-41 716540001530 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 716540001531 HMMPfam hit to PF01219, Prokaryotic diacylglycerol kinase, score 4.1e-55 716540001532 3 transmembrane helices predicted for EAM_0263 by TMHMM2.0 at aa 30-49, 54-76 and 97-119 716540001533 PS01069 Prokaryotic diacylglycerol kinase signature. 716540001534 LexA repressor; Validated; Region: PRK00215 716540001535 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 716540001536 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 716540001537 Catalytic site [active] 716540001538 HMMPfam hit to PF01726, LexA DNA binding domain, score 8.2e-38 716540001539 HMMPfam hit to PF00717, Peptidase S24-like, score 3.7e-21 716540001540 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 716540001541 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 716540001542 12 transmembrane helices predicted for EAM_0265 by TMHMM2.0 at aa 12-31, 41-63, 83-105, 136-155, 162-181, 185-207, 241-263, 267-289, 319-341, 356-378, 385-404 and 409-428 716540001543 HMMPfam hit to PF01554, MatE, score 6.2e-36 716540001544 hypothetical protein; Provisional; Region: PRK10428 716540001545 HMMPfam hit to PF05532, CsbD-like, score 1.3e-21 716540001546 ferric uptake regulator; Provisional; Region: fur; PRK09462 716540001547 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 716540001548 metal binding site 2 [ion binding]; metal-binding site 716540001549 putative DNA binding helix; other site 716540001550 metal binding site 1 [ion binding]; metal-binding site 716540001551 dimer interface [polypeptide binding]; other site 716540001552 structural Zn2+ binding site [ion binding]; other site 716540001553 HMMPfam hit to PF01475, Ferric uptake regulator family, score 2e-06 716540001554 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 716540001555 Signal peptide predicted for EAM_0268 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 29 and 30 716540001556 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 716540001557 Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112 716540001558 Protein of unknown function (DUF968); Region: DUF968; pfam06147 716540001559 HMMPfam hit to PF06914, Protein of unknown function (DUF1277), score 2.2e-29 716540001560 PS00190 Cytochrome c family heme-binding site signature. 716540001561 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 716540001562 HMMPfam hit to PF06530, Phage antitermination protein Q, score 1.2e-46 716540001563 PS00228 Tubulin-beta mRNA autoregulation signal. 716540001564 Predicted helix-turn-helix motif with score 1524.000, SD 4.38 at aa 79-100, sequence ISKRALGRKLKLSEGMIRIKFQ 716540001565 3 transmembrane helices predicted for EAM_0275 by TMHMM2.0 at aa 7-29, 49-71 and 106-128 716540001566 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 716540001567 Signal peptide predicted for EAM_0275 by SignalP 2.0 HMM (Signal peptide probability 0.982) with cleavage site probability 0.892 between residues 30 and 31 716540001568 3 transmembrane helices predicted for EAM_0276 by TMHMM2.0 at aa 39-61, 82-101 and 138-160 716540001569 2 transmembrane helices predicted for EAM_0277 by TMHMM2.0 at aa 22-44 and 79-101 716540001570 2 transmembrane helices predicted for EAM_0278 by TMHMM2.0 at aa 272-294 and 301-323 716540001571 DNA methylase; Region: N6_N4_Mtase; pfam01555 716540001572 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 716540001573 HMMPfam hit to PF01555, DNA methylase, score 1.3e-12 716540001574 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 716540001575 HMMPfam hit to PF03681, Uncharacterised protein family (UPF0150), score 1.1e-15 716540001576 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 716540001577 HMMPfam hit to PF05106, Phage holin family (Lysis protein S), score 1.7e-12 716540001578 3 transmembrane helices predicted for EAM_0282 by TMHMM2.0 at aa 20-42, 75-97 and 112-129 716540001579 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 716540001580 PS00294 Prenyl group binding site (CAAX box). 716540001581 HMMPfam hit to PF06890, Bacteriophage Mu Gp45 protein, score 5.3e-50 716540001582 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 716540001583 8 transmembrane helices predicted for EAM_0286 by TMHMM2.0 at aa 9-31, 70-89, 118-140, 160-182, 195-214, 254-276, 283-305 and 320-342 716540001584 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 716540001585 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 716540001586 Ligand binding site; other site 716540001587 Putative Catalytic site; other site 716540001588 DXD motif; other site 716540001589 2 transmembrane helices predicted for EAM_0287 by TMHMM2.0 at aa 227-249 and 264-286 716540001590 PS00017 ATP/GTP-binding site motif A (P-loop). 716540001591 HMMPfam hit to PF00535, Glycosyl transferase family, score 1.2e-28 716540001592 Predicted membrane protein [Function unknown]; Region: COG2246 716540001593 GtrA-like protein; Region: GtrA; pfam04138 716540001594 4 transmembrane helices predicted for EAM_0288 by TMHMM2.0 at aa 7-29, 34-53, 66-84 and 94-116 716540001595 HMMPfam hit to PF04138, GtrA-like protein, score 6.7e-13 716540001596 HMMPfam hit to PF06183, DinI-like family, score 9.6e-21 716540001597 Signal peptide predicted for EAM_0290 by SignalP 2.0 HMM (Signal peptide probability 0.768) with cleavage site probability 0.732 between residues 21 and 22 716540001598 HMMPfam hit to PF00589, Phage integrase family, score 5.1e-09 716540001599 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 716540001600 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 716540001601 FMN binding site [chemical binding]; other site 716540001602 active site 716540001603 catalytic residues [active] 716540001604 substrate binding site [chemical binding]; other site 716540001605 HMMPfam hit to PF01207, Dihydrouridine synthase (Dus), score 4e-131 716540001606 PS01136 Uncharacterized protein family UPF0034 signature. 716540001607 Phage shock protein G (Phageshock_PspG); Region: Phageshock_PspG; cl11511 716540001608 Signal peptide predicted for EAM_0293 by SignalP 2.0 HMM (Signal peptide probability 0.942) with cleavage site probability 0.378 between residues 42 and 43 716540001609 2 transmembrane helices predicted for EAM_0293 by TMHMM2.0 at aa 7-29 and 39-61 716540001610 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 716540001611 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 716540001612 NADP binding site [chemical binding]; other site 716540001613 dimer interface [polypeptide binding]; other site 716540001614 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 6.8e-32 716540001615 PS01162 Quinone oxidoreductase / zeta-crystallin signature. 716540001616 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like domain, score 3.8e-15 716540001617 replicative DNA helicase; Provisional; Region: PRK08006 716540001618 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 716540001619 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 716540001620 Walker A motif; other site 716540001621 ATP binding site [chemical binding]; other site 716540001622 Walker B motif; other site 716540001623 DNA binding loops [nucleotide binding] 716540001624 HMMPfam hit to PF00772, DnaB-like helicase N terminal domain, score 2.3e-53 716540001625 HMMPfam hit to PF03796, DnaB-like helicase C terminal domain, score 4.2e-137 716540001626 PS00017 ATP/GTP-binding site motif A (P-loop). 716540001627 Predicted helix-turn-helix motif with score 1279.000, SD 3.54 at aa 366-387, sequence RSLKALAKELQVPVVALSQLNR 716540001628 HMMPfam hit to PF02588, Uncharacterized BCR, YitT family COG1284, score 1.1e-07 716540001629 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 716540001630 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 716540001631 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716540001632 homodimer interface [polypeptide binding]; other site 716540001633 catalytic residue [active] 716540001634 HMMPfam hit to PF00155, Aminotransferase class I and II, score 1.9e-113 716540001635 PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 716540001636 Uncharacterized conserved protein [Function unknown]; Region: COG0432 716540001637 HMMPfam hit to PF01894, Uncharacterised protein family UPF0047, score 7.5e-51 716540001638 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 716540001639 HMMPfam hit to PF04237, Protein of unknown function (DUF419), score 1.4e-22 716540001640 unique vs ECA 716540001641 LysM domain; Region: LysM; pfam01476 716540001642 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 716540001643 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 716540001644 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 716540001645 PS00017 ATP/GTP-binding site motif A (P-loop). 716540001646 HMMPfam hit to PF02368, no description, score 0.29 716540001647 HMMPfam hit to PF02368, no description, score 0.029 716540001648 HMMPfam hit to PF02369, Bacterial Ig-like domain (group 1), score 0.0081 716540001649 Predicted helix-turn-helix motif with score 1133.000, SD 3.05 at aa 66-87, sequence ETSASVAKKFHITPEALRKLNL 716540001650 Signal peptide predicted for EAM_0301 by SignalP 2.0 HMM (Signal peptide probability 0.810) with cleavage site probability 0.549 between residues 38 and 39 716540001651 1 transmembrane helix predicted for EAM_0302 by TMHMM2.0 at aa 43-60 716540001652 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 716540001653 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 716540001654 putative NAD(P) binding site [chemical binding]; other site 716540001655 putative substrate binding site [chemical binding]; other site 716540001656 catalytic Zn binding site [ion binding]; other site 716540001657 structural Zn binding site [ion binding]; other site 716540001658 dimer interface [polypeptide binding]; other site 716540001659 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 1.5e-35 716540001660 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 716540001661 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like domain, score 5e-31 716540001662 PS00190 Cytochrome c family heme-binding site signature. 716540001663 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 716540001664 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 716540001665 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 716540001666 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 716540001667 HMMPfam hit to PF00005, ABC transporter, score 1.3e-42 716540001668 PS00211 ABC transporters family signature. 716540001669 PS00017 ATP/GTP-binding site motif A (P-loop). 716540001670 PS00211 ABC transporters family signature. 716540001671 PS00190 Cytochrome c family heme-binding site signature. 716540001672 PS00017 ATP/GTP-binding site motif A (P-loop). 716540001673 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 716540001674 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 716540001675 dimer interface [polypeptide binding]; other site 716540001676 ssDNA binding site [nucleotide binding]; other site 716540001677 tetramer (dimer of dimers) interface [polypeptide binding]; other site 716540001678 HMMPfam hit to PF00436, Single-strand binding protein family, score 5.9e-36 716540001679 PS00735 Single-strand binding protein family signature 1. 716540001680 PS00736 Single-strand binding protein family signature 2. 716540001681 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 716540001682 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 716540001683 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 716540001684 HMMPfam hit to PF08479, POTRA domain, ShlB-type, score 0.00075 716540001685 HMMPfam hit to PF03865, Haemolysin secretion/activation protein ShlB, score 1.8e-08 716540001686 unique vs ECA 716540001687 1 transmembrane helix predicted for EAM_0311 by TMHMM2.0 at aa 13-35 716540001688 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 716540001689 Signal peptide predicted for EAM_0312 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.846 between residues 19 and 20 716540001690 Transposase; Region: HTH_Tnp_1; pfam01527 716540001691 HMMPfam hit to PF01527, Transposase, score 8.7e-13 716540001692 Predicted helix-turn-helix motif with score 1290.000, SD 3.58 at aa 22-43, sequence TRVNVICDALGISAATLYSWKK 716540001693 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 716540001694 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716540001695 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 8.3e-14 716540001696 PS00041 Bacterial regulatory proteins, araC family signature. 716540001697 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 4.9e-09 716540001698 Predicted helix-turn-helix motif with score 1570.000, SD 4.53 at aa 21-42, sequence LSIEEVAAKSGYSKWHLQRMFR 716540001699 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 716540001700 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 716540001701 DNA binding residues [nucleotide binding] 716540001702 dimer interface [polypeptide binding]; other site 716540001703 [2Fe-2S] cluster binding site [ion binding]; other site 716540001704 Predicted helix-turn-helix motif with score 1453.000, SD 4.14 at aa 13-34, sequence LTPGDVAQRCGVAVSTLHFYES 716540001705 HMMPfam hit to PF00376, MerR family regulatory protein, score 1.9e-11 716540001706 PS00552 Bacterial regulatory proteins, merR family signature. 716540001707 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 716540001708 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 716540001709 putative C-terminal domain interface [polypeptide binding]; other site 716540001710 putative GSH binding site (G-site) [chemical binding]; other site 716540001711 putative dimer interface [polypeptide binding]; other site 716540001712 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 716540001713 putative N-terminal domain interface [polypeptide binding]; other site 716540001714 putative dimer interface [polypeptide binding]; other site 716540001715 putative substrate binding pocket (H-site) [chemical binding]; other site 716540001716 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal domain, score 6.6e-13 716540001717 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 716540001718 HMMPfam hit to PF00860, Permease family, score 2.3e-99 716540001719 12 transmembrane helices predicted for EAM_0319 by TMHMM2.0 at aa 29-51, 56-78, 85-107, 112-134, 146-165, 175-197, 202-224, 244-266, 335-357, 361-378, 391-413 and 428-447 716540001720 HMMPfam hit to PF00916, Sulfate transporter family, score 0.00014 716540001721 PS00017 ATP/GTP-binding site motif A (P-loop). 716540001722 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 716540001723 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 716540001724 Signal peptide predicted for EAM_0320 by SignalP 2.0 HMM (Signal peptide probability 0.960) with cleavage site probability 0.744 between residues 20 and 21 716540001725 11 transmembrane helices predicted for EAM_0320 by TMHMM2.0 at aa 4-26, 28-50, 85-107, 114-136, 159-181, 188-210, 230-252, 271-293, 313-335, 361-383 and 398-420 716540001726 HMMPfam hit to PF00999, Sodium/hydrogen exchanger family, score 1.5e-77 716540001727 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716540001728 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716540001729 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 716540001730 putative dimerization interface [polypeptide binding]; other site 716540001731 HMMPfam hit to PF03466, LysR substrate binding domain, score 2.9e-46 716540001732 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.9e-22 716540001733 PS00044 Bacterial regulatory proteins, lysR family signature. 716540001734 Predicted helix-turn-helix motif with score 1900.000, SD 5.66 at aa 16-37, sequence QSFTRAAEKLYVTQPTISKMLR 716540001735 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 716540001736 4 transmembrane helices predicted for EAM_0322 by TMHMM2.0 at aa 13-32, 42-64, 71-93 and 103-122 716540001737 HMMPfam hit to PF03788, LrgA family, score 9.9e-38 716540001738 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 716540001739 6 transmembrane helices predicted for EAM_0323 by TMHMM2.0 at aa 4-19, 31-53, 63-85, 90-112, 149-171 and 203-225 716540001740 HMMPfam hit to PF04172, LrgB-like family, score 1.4e-103 716540001741 YfaZ precursor; Region: YfaZ; pfam07437 716540001742 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 716540001743 HMMPfam hit to PF07437, YfaZ precursor, score 7.4e-47 716540001744 Signal peptide predicted for EAM_0324 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.995 between residues 22 and 23 716540001745 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 716540001746 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 716540001747 Na binding site [ion binding]; other site 716540001748 13 transmembrane helices predicted for EAM_0325 by TMHMM2.0 at aa 35-57, 78-100, 105-127, 148-170, 185-207, 214-236, 266-288, 309-331, 364-386, 407-426, 431-453, 465-487 and 497-519 716540001749 PS00457 Sodium:solute symporter family signature 2. 716540001750 HMMPfam hit to PF00474, Sodium:solute symporter family, score 2.9e-185 716540001751 PS00456 Sodium:solute symporter family signature 1. 716540001752 Signal peptide predicted for EAM_0325 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 20 and 21 716540001753 Predicted membrane protein [Function unknown]; Region: COG3162 716540001754 HMMPfam hit to PF04341, Protein of unknown function, DUF485, score 1e-52 716540001755 2 transmembrane helices predicted for EAM_0326 by TMHMM2.0 at aa 25-47 and 62-84 716540001756 acetyl-CoA synthetase; Provisional; Region: PRK00174 716540001757 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 716540001758 active site 716540001759 CoA binding site [chemical binding]; other site 716540001760 acyl-activating enzyme (AAE) consensus motif; other site 716540001761 AMP binding site [chemical binding]; other site 716540001762 acetate binding site [chemical binding]; other site 716540001763 HMMPfam hit to PF00501, AMP-binding enzyme, score 1.7e-138 716540001764 PS00455 AMP-binding domain signature. 716540001765 PS00018 EF-hand calcium-binding domain. 716540001766 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 716540001767 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 716540001768 Signal peptide predicted for EAM_0328 by SignalP 2.0 HMM (Signal peptide probability 0.915) with cleavage site probability 0.601 between residues 28 and 29 716540001769 8 transmembrane helices predicted for EAM_0328 by TMHMM2.0 at aa 7-29, 49-71, 84-106, 160-179, 206-228, 233-255, 326-348 and 363-385 716540001770 HMMPfam hit to PF00375, Sodium:dicarboxylate symporter family, score 5.4e-216 716540001771 PS00713 Sodium:dicarboxylate symporter family signature 1. 716540001772 PS00714 Sodium:dicarboxylate symporter family signature 2. 716540001773 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 716540001774 PAS domain; Region: PAS_9; pfam13426 716540001775 putative active site [active] 716540001776 heme pocket [chemical binding]; other site 716540001777 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 716540001778 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 716540001779 dimer interface [polypeptide binding]; other site 716540001780 putative CheW interface [polypeptide binding]; other site 716540001781 HMMPfam hit to PF00989, PAS fold, score 2.3e-05 716540001782 HMMPfam hit to PF08447, PAS fold, score 8.4e-16 716540001783 2 transmembrane helices predicted for EAM_0329 by TMHMM2.0 at aa 167-189 and 193-212 716540001784 HMMPfam hit to PF00672, HAMP domain, score 0.00041 716540001785 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 1.7e-74 716540001786 Predicted helix-turn-helix motif with score 1049.000, SD 2.76 at aa 80-101, sequence VGLSDIAQLSNLTRQSIAMLKD 716540001787 ATPase involved in DNA repair; Region: DUF3686; pfam12458 716540001788 microcin B17 transporter; Reviewed; Region: PRK11098 716540001789 8 transmembrane helices predicted for EAM_0334 by TMHMM2.0 at aa 9-31, 61-83, 90-112, 146-168, 211-233, 243-265, 313-331 and 335-357 716540001790 HMMPfam hit to PF05992, SbmA/BacA-like family, score 1.9e-60 716540001791 Signal peptide predicted for EAM_0334 by SignalP 2.0 HMM (Signal peptide probability 0.992) with cleavage site probability 0.681 between residues 25 and 26 716540001792 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 716540001793 putative active site [active] 716540001794 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 716540001795 heme pocket [chemical binding]; other site 716540001796 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 716540001797 putative active site [active] 716540001798 heme pocket [chemical binding]; other site 716540001799 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 716540001800 putative active site [active] 716540001801 heme pocket [chemical binding]; other site 716540001802 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 716540001803 metal binding site [ion binding]; metal-binding site 716540001804 active site 716540001805 I-site; other site 716540001806 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 716540001807 HMMPfam hit to PF00989, PAS fold, score 6.7e-08 716540001808 HMMPfam hit to PF00989, PAS fold, score 3.6e-05 716540001809 HMMPfam hit to PF00990, GGDEF domain, score 2.4e-64 716540001810 HMMPfam hit to PF00563, EAL domain, score 7.3e-116 716540001811 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 716540001812 Signal peptide predicted for EAM_0336 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.785 between residues 42 and 43 716540001813 1 transmembrane helix predicted for EAM_0336 by TMHMM2.0 at aa 20-42 716540001814 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 716540001815 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 716540001816 Signal peptide predicted for EAM_0337 by SignalP 2.0 HMM (Signal peptide probability 0.732) with cleavage site probability 0.731 between residues 23 and 24 716540001817 HMMPfam hit to PF00732, GMC oxidoreductase, score 5e-05 716540001818 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 716540001819 PTS system arbutin-specific transporter subunit IIB; Provisional; Region: PRK09702 716540001820 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 716540001821 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 716540001822 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 716540001823 Signal peptide predicted for EAM_0338 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.988 between residues 20 and 21 716540001824 PS00190 Cytochrome c family heme-binding site signature. 716540001825 PS00190 Cytochrome c family heme-binding site signature. 716540001826 HMMPfam hit to PF00034, Cytochrome c, score 2.5e-08 716540001827 PS00190 Cytochrome c family heme-binding site signature. 716540001828 Acyltransferase family; Region: Acyl_transf_3; pfam01757 716540001829 Signal peptide predicted for EAM_0339 by SignalP 2.0 HMM (Signal peptide probability 0.713) with cleavage site probability 0.698 between residues 36 and 37 716540001830 HMMPfam hit to PF01757, Acyltransferase family, score 1.8e-15 716540001831 10 transmembrane helices predicted for EAM_0339 by TMHMM2.0 at aa 12-31, 46-68, 88-107, 135-157, 162-182, 197-219, 228-250, 255-272, 284-306 and 326-348 716540001832 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 716540001833 DNA binding site [nucleotide binding] 716540001834 active site 716540001835 Int/Topo IB signature motif; other site 716540001836 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716540001837 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716540001838 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 716540001839 putative effector binding pocket; other site 716540001840 putative dimerization interface [polypeptide binding]; other site 716540001841 HMMPfam hit to PF03466, LysR substrate binding domain, score 5.5e-51 716540001842 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 2e-17 716540001843 PS00044 Bacterial regulatory proteins, lysR family signature. 716540001844 Predicted helix-turn-helix motif with score 1380.000, SD 3.89 at aa 21-42, sequence GSFTAAAGRLHLTCSAVSKSIA 716540001845 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 716540001846 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 716540001847 NAD(P) binding site [chemical binding]; other site 716540001848 active site 716540001849 Signal peptide predicted for EAM_0343 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.990 between residues 19 and 20 716540001850 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase family, score 5.4e-06 716540001851 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 716540001852 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716540001853 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716540001854 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 716540001855 putative effector binding pocket; other site 716540001856 dimerization interface [polypeptide binding]; other site 716540001857 HMMPfam hit to PF03466, LysR substrate binding domain, score 6.2e-42 716540001858 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 7e-14 716540001859 PS00044 Bacterial regulatory proteins, lysR family signature. 716540001860 Predicted helix-turn-helix motif with score 1718.000, SD 5.04 at aa 20-41, sequence LSYTEAAKALGLAKSSVSKEIS 716540001861 LysE type translocator; Region: LysE; cl00565 716540001862 6 transmembrane helices predicted for EAM_0347 by TMHMM2.0 at aa 5-27, 40-62, 67-89, 118-140, 150-172 and 185-207 716540001863 HMMPfam hit to PF01810, LysE type translocator, score 1.2e-32 716540001864 1 transmembrane helix predicted for EAM_0348 by TMHMM2.0 at aa 12-34 716540001865 trehalase; Provisional; Region: treF; PRK13270 716540001866 Trehalase; Region: Trehalase; cl17346 716540001867 HMMPfam hit to PF01204, Trehalase, score 4.8e-218 716540001868 PS00927 Trehalase signature 1. 716540001869 PS00928 Trehalase signature 2. 716540001870 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 716540001871 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 716540001872 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 716540001873 HMMPfam hit to PF00756, esterase, score 2.4e-07 716540001874 HMMPfam hit to PF02922, Isoamylase N-terminal domain, score 0.03 716540001875 1 transmembrane helix predicted for EAM_0350 by TMHMM2.0 at aa 7-29 716540001876 Signal peptide predicted for EAM_0350 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.991 between residues 23 and 24 716540001877 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 716540001878 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 716540001879 HMMPfam hit to PF07063, Protein of unknown function (DUF1338), score 2e-47 716540001880 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 716540001881 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716540001882 active site 716540001883 motif I; other site 716540001884 motif II; other site 716540001885 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716540001886 HMMPfam hit to PF08282, haloacid dehalogenase-like hydrolase, score 4.4e-64 716540001887 HMMPfam hit to PF05116, Sucrose-6F-phosphate phosphohydrolase, score 2.8e-05 716540001888 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 5.9e-08 716540001889 PS01229 Hypothetical cof family signature 2. 716540001890 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 716540001891 chaperone protein HchA; Provisional; Region: PRK04155 716540001892 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 716540001893 conserved cys residue [active] 716540001894 HMMPfam hit to PF01965, DJ-1/PfpI family, score 0.0013 716540001895 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 716540001896 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 716540001897 FMN binding site [chemical binding]; other site 716540001898 active site 716540001899 substrate binding site [chemical binding]; other site 716540001900 catalytic residue [active] 716540001901 HMMPfam hit to PF00724, NADH:flavin oxidoreductase / NADH oxidas, score 9.5e-89 716540001902 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 716540001903 dimerization interface [polypeptide binding]; other site 716540001904 putative DNA binding site [nucleotide binding]; other site 716540001905 putative Zn2+ binding site [ion binding]; other site 716540001906 glucose-1-dehydrogenase; Provisional; Region: PRK08936 716540001907 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 716540001908 NAD(P) binding site [chemical binding]; other site 716540001909 active site 716540001910 HMMPfam hit to PF00106, short chain dehydrogenase, score 3.4e-26 716540001911 PS00061 Short-chain dehydrogenases/reductases family signature. 716540001912 Domain of unknown function (DUF4354); Region: DUF4354; pfam14263 716540001913 Signal peptide predicted for EAM_0357 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 21 and 22 716540001914 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 716540001915 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 716540001916 N-terminal plug; other site 716540001917 ligand-binding site [chemical binding]; other site 716540001918 PS00430 TonB-dependent receptor proteins signature 1. 716540001919 1 transmembrane helix predicted for EAM_0358 by TMHMM2.0 at aa 70-92 716540001920 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 2e-23 716540001921 HMMPfam hit to PF00593, TonB dependent receptor, score 6.6e-24 716540001922 PS01156 TonB-dependent receptor proteins signature 2. 716540001923 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 716540001924 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 716540001925 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 716540001926 IucA / IucC family; Region: IucA_IucC; pfam04183 716540001927 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 716540001928 HMMPfam hit to PF04183, IucA / IucC family, score 5.8e-175 716540001929 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540001930 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 716540001931 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 716540001932 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540001933 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 716540001934 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716540001935 catalytic residue [active] 716540001936 HMMPfam hit to PF00282, Pyridoxal-dependent decarboxylase conse, score 1.3e-38 716540001937 Type 6 secretion system 1 716540001938 Clostridium P-47 protein; Region: Clostridium_P47; pfam06597 716540001939 2 transmembrane helices predicted for EAM_0362 by TMHMM2.0 at aa 389-411 and 468-490 716540001940 Clostridium P-47 protein; Region: Clostridium_P47; pfam06597 716540001941 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 716540001942 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 716540001943 HMMPfam hit to PF05593, RHS Repeat, score 2.8 716540001944 HMMPfam hit to PF05593, RHS Repeat, score 6.4 716540001945 HMMPfam hit to PF05593, RHS Repeat, score 0.017 716540001946 HMMPfam hit to PF05593, RHS Repeat, score 0.11 716540001947 HMMPfam hit to PF05593, RHS Repeat, score 6.9 716540001948 HMMPfam hit to PF05593, RHS Repeat, score 0.91 716540001949 HMMPfam hit to PF05593, RHS Repeat, score 0.045 716540001950 HMMPfam hit to PF05593, RHS Repeat, score 1.2 716540001951 HMMPfam hit to PF05593, RHS Repeat, score 1.9 716540001952 PS00237 G-protein coupled receptors signature. 716540001953 PS00583 pfkB family of carbohydrate kinases signature 1. 716540001954 3 transmembrane helices predicted for EAM_0366 by TMHMM2.0 at aa 1367-1389, 1396-1418 and 1433-1452 716540001955 Protein of unknown function (DUF770); Region: DUF770; pfam05591 716540001956 HMMPfam hit to PF05591, Protein of unknown function (DUF770), score 3.9e-74 716540001957 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 716540001958 Protein of unknown function (DUF877); Region: DUF877; pfam05943 716540001959 HMMPfam hit to PF05943, Protein of unknown function (DUF877), score 5.3e-293 716540001960 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 716540001961 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 716540001962 HMMPfam hit to PF05936, Bacterial protein of unknown function (DUF87, score 2.5e-127 716540001963 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 716540001964 1 transmembrane helix predicted for EAM_0370 by TMHMM2.0 at aa 190-212 716540001965 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 716540001966 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 716540001967 ligand binding site [chemical binding]; other site 716540001968 3 transmembrane helices predicted for EAM_0371 by TMHMM2.0 at aa 7-29, 33-51 and 316-338 716540001969 HMMPfam hit to PF00691, OmpA family, score 1.8e-20 716540001970 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 716540001971 HMMPfam hit to PF05638, Protein of unknown function (DUF796), score 1.2e-61 716540001972 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 716540001973 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716540001974 Walker A motif; other site 716540001975 ATP binding site [chemical binding]; other site 716540001976 Walker B motif; other site 716540001977 arginine finger; other site 716540001978 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716540001979 Walker A motif; other site 716540001980 ATP binding site [chemical binding]; other site 716540001981 Walker B motif; other site 716540001982 arginine finger; other site 716540001983 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 716540001984 HMMPfam hit to PF02861, Clp amino terminal domain, score 0.0074 716540001985 Predicted helix-turn-helix motif with score 1321.000, SD 3.69 at aa 127-148, sequence LRCDDLWPLFSLSESQISRLKP 716540001986 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 1.2e-07 716540001987 PS00017 ATP/GTP-binding site motif A (P-loop). 716540001988 PS00870 Chaperonins clpA/B signature 1. 716540001989 HMMPfam hit to PF07724, ATPase family associated with various cellul, score 3.8e-80 716540001990 HMMPfam hit to PF07728, ATPase family associated with various cellul, score 4e-05 716540001991 PS00017 ATP/GTP-binding site motif A (P-loop). 716540001992 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 716540001993 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 716540001994 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 716540001995 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 716540001996 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 716540001997 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 716540001998 HMMPfam hit to PF04524, Protein of unknown function, DUF586, score 2.3e-10 716540001999 PS00307 Legume lectins beta-chain signature. 716540002000 PAAR motif; Region: PAAR_motif; pfam05488 716540002001 2 transmembrane helices predicted for EAM_0378 by TMHMM2.0 at aa 21-43 and 48-67 716540002002 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 716540002003 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 716540002004 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 716540002005 Signal peptide predicted for EAM_0379 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.974 between residues 35 and 36 716540002006 3 transmembrane helices predicted for EAM_0379 by TMHMM2.0 at aa 9-31, 46-68 and 366-388 716540002007 HMMPfam hit to PF06761, ImcF-related, score 8.7e-71 716540002008 PS00017 ATP/GTP-binding site motif A (P-loop). 716540002009 HMMPfam hit to PF06744, Protein of unknown function (DUF1215), score 2.3e-37 716540002010 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 716540002011 HMMPfam hit to PF06812, ImpA-related N-terminal, score 3.2e-16 716540002012 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 716540002013 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 716540002014 HMMPfam hit to PF05947, Bacterial protein of unknown function (DUF87, score 2.9e-197 716540002015 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 716540002016 HMMPfam hit to PF06996, Protein of unknown function (DUF1305), score 5.1e-49 716540002017 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 716540002018 Signal peptide predicted for EAM_0383 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.921 between residues 26 and 27 716540002019 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540002020 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 716540002021 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 716540002022 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 716540002023 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 716540002024 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 716540002025 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 716540002026 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 716540002027 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 716540002028 Signal peptide predicted for EAM_0393 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.858 between residues 32 and 33 716540002029 1 transmembrane helix predicted for EAM_0393 by TMHMM2.0 at aa 10-32 716540002030 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 716540002031 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 716540002032 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 716540002033 HMMPfam hit to PF07025, Protein of unknown function (DUF1316), score 8.5e-29 716540002034 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 716540002035 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 716540002036 ImpA domain protein; Region: DUF3702; pfam12486 716540002037 HMMPfam hit to PF06812, ImpA-related N-terminal, score 3.3e-20 716540002038 Predicted helix-turn-helix motif with score 1049.000, SD 2.76 at aa 113-134, sequence QRIQQLMRRLPLNYSDLSQLYR 716540002039 PS00217 Sugar transport proteins signature 2. 716540002040 PS01159 WW/rsp5/WWP domain signature. 716540002041 PS00017 ATP/GTP-binding site motif A (P-loop). 716540002042 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 716540002043 Methyltransferase domain; Region: Methyltransf_31; pfam13847 716540002044 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716540002045 S-adenosylmethionine binding site [chemical binding]; other site 716540002046 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 716540002047 HMMPfam hit to PF08242, Methyltransferase domain, score 1.4e-08 716540002048 HMMPfam hit to PF08241, Methyltransferase domain, score 1.4e-05 716540002049 histidyl-tRNA synthetase; Region: hisS; TIGR00442 716540002050 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 716540002051 motif 1; other site 716540002052 dimer interface [polypeptide binding]; other site 716540002053 active site 716540002054 motif 2; other site 716540002055 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 716540002056 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 716540002057 Signal peptide predicted for EAM_0405 by SignalP 2.0 HMM (Signal peptide probability 0.822) with cleavage site probability 0.257 between residues 19 and 20 716540002058 HMMPfam hit to PF02558, Ketopantoate reductase PanE/ApbA, score 8.3e-06 716540002059 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540002060 HMMPfam hit to PF08546, Ketopantoate reductase PanE/ApbA C terminal, score 3.7e-05 716540002061 histidyl-tRNA synthetase; Region: hisS; TIGR00442 716540002062 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 716540002063 dimer interface [polypeptide binding]; other site 716540002064 motif 1; other site 716540002065 active site 716540002066 motif 2; other site 716540002067 motif 3; other site 716540002068 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 716540002069 anticodon binding site; other site 716540002070 HMMPfam hit to PF00587, tRNA synthetase class II core domain (G,, score 2.8e-25 716540002071 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 716540002072 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 716540002073 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 716540002074 ATP-grasp domain; Region: ATP-grasp_4; cl17255 716540002075 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 716540002076 HMMPfam hit to PF01071, Phosphoribosylglycinamide synthetase, ATP-gr, score 2.4e-35 716540002077 pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380 716540002078 active site 716540002079 nucleotide binding site [chemical binding]; other site 716540002080 HIGH motif; other site 716540002081 KMSKS motif; other site 716540002082 HMMPfam hit to PF02569, Pantoate-beta-alanine ligase, score 2.9e-13 716540002083 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 716540002084 active site 716540002085 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 716540002086 dimer interface [polypeptide binding]; other site 716540002087 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 716540002088 Ligand Binding Site [chemical binding]; other site 716540002089 Molecular Tunnel; other site 716540002090 PS00017 ATP/GTP-binding site motif A (P-loop). 716540002091 HMMPfam hit to PF00733, Asparagine synthase, score 1.8e-37 716540002092 HMMPfam hit to PF00310, Glutamine amidotransferases class-II, score 6.1e-08 716540002093 Cupin domain; Region: Cupin_2; pfam07883 716540002094 HMMPfam hit to PF07883, Cupin domain, score 6e-08 716540002095 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 716540002096 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540002097 putative transporter; Provisional; Region: PRK10054 716540002098 putative substrate translocation pore; other site 716540002099 12 transmembrane helices predicted for EAM_0411 by TMHMM2.0 at aa 25-47, 57-79, 91-108, 112-129, 150-172, 182-204, 225-247, 267-289, 301-316, 326-348, 360-379 and 389-406 716540002100 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.6e-41 716540002101 PS00216 Sugar transport proteins signature 1. 716540002102 putative transcriptional regulator; Provisional; Region: PRK11640 716540002103 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 716540002104 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 716540002105 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 716540002106 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 716540002107 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 716540002108 DsbD alpha interface [polypeptide binding]; other site 716540002109 catalytic residues [active] 716540002110 PS00194 Thioredoxin family active site. 716540002111 7 transmembrane helices predicted for EAM_0414 by TMHMM2.0 at aa 171-193, 213-235, 247-269, 300-322, 329-351, 361-383 and 390-412 716540002112 HMMPfam hit to PF02683, Cytochrome C biogenesis protein transmembran, score 6.8e-08 716540002113 Signal peptide predicted for EAM_0414 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.958 between residues 23 and 24 716540002114 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 716540002115 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 716540002116 11 transmembrane helices predicted for EAM_0415 by TMHMM2.0 at aa 20-39, 46-68, 88-110, 131-153, 163-185, 226-245, 260-277, 284-306, 329-346, 359-381 and 410-432 716540002117 HMMPfam hit to PF03605, Anaerobic c4-dicarboxylate membrane transpo, score 5.1e-217 716540002118 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 716540002119 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 716540002120 Aspartase; Region: Aspartase; cd01357 716540002121 active sites [active] 716540002122 tetramer interface [polypeptide binding]; other site 716540002123 HMMPfam hit to PF00206, Lyase, score 4.4e-163 716540002124 PS00163 Fumarate lyases signature. 716540002125 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 716540002126 3 transmembrane helices predicted for EAM_0417 by TMHMM2.0 at aa 4-21, 26-48 and 79-101 716540002127 HMMPfam hit to PF04186, FxsA cytoplasmic membrane protein, score 4.5e-47 716540002128 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 716540002129 oligomerisation interface [polypeptide binding]; other site 716540002130 mobile loop; other site 716540002131 roof hairpin; other site 716540002132 HMMPfam hit to PF00166, Chaperonin 10 Kd subunit, score 5.3e-41 716540002133 PS00681 Chaperonins cpn10 signature. 716540002134 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 716540002135 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 716540002136 ring oligomerisation interface [polypeptide binding]; other site 716540002137 ATP/Mg binding site [chemical binding]; other site 716540002138 stacking interactions; other site 716540002139 hinge regions; other site 716540002140 HMMPfam hit to PF00118, TCP-1/cpn60 chaperonin family, score 9.3e-187 716540002141 PS00296 Chaperonins cpn60 signature. 716540002142 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 716540002143 Signal peptide predicted for EAM_0420 by SignalP 2.0 HMM (Signal peptide probability 0.878) with cleavage site probability 0.511 between residues 37 and 38 716540002144 1 transmembrane helix predicted for EAM_0420 by TMHMM2.0 at aa 15-37 716540002145 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540002146 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 716540002147 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 716540002148 FeS/SAM binding site; other site 716540002149 HMMPfam hit to PF04055, Radical SAM superfamily, score 1.4e-10 716540002150 elongation factor P; Validated; Region: PRK00529 716540002151 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 716540002152 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 716540002153 RNA binding site [nucleotide binding]; other site 716540002154 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 716540002155 RNA binding site [nucleotide binding]; other site 716540002156 HMMPfam hit to PF08207, Elongation factor P (EF-P) KOW-like domain, score 1e-29 716540002157 HMMPfam hit to PF01132, Elongation factor P (EF-P) OB domain, score 1.3e-29 716540002158 PS01275 Elongation factor P signature. 716540002159 Papain-like cysteine protease AvrRpt2; Region: Peptidase_C70; pfam12385 716540002160 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540002161 Entericidin EcnA/B family; Region: Entericidin; cl02322 716540002162 Signal peptide predicted for EAM_0424 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.991 between residues 22 and 23 716540002163 HMMPfam hit to PF08085, Entericidin EcnA/B family, score 3.3e-20 716540002164 1 transmembrane helix predicted for EAM_0424 by TMHMM2.0 at aa 7-29 716540002165 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540002166 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 716540002167 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 716540002168 HMMPfam hit to PF00061, Lipocalin / cytosolic fatty-acid binding, score 0.0019 716540002169 HMMPfam hit to PF08212, Lipocalin-like domain, score 3.6e-66 716540002170 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 716540002171 PS00213 Lipocalin signature. 716540002172 Signal peptide predicted for EAM_0425 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.306 between residues 27 and 28 716540002173 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540002174 poxB regulator PoxA; Provisional; Region: PRK09350 716540002175 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 716540002176 motif 1; other site 716540002177 dimer interface [polypeptide binding]; other site 716540002178 active site 716540002179 motif 2; other site 716540002180 motif 3; other site 716540002181 HMMPfam hit to PF00152, tRNA synthetases class II (D, K and N), score 1.6e-76 716540002182 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 716540002183 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 716540002184 putative mechanosensitive channel protein; Provisional; Region: PRK10929 716540002185 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 716540002186 Mechanosensitive ion channel; Region: MS_channel; pfam00924 716540002187 HMMPfam hit to PF00924, Mechanosensitive ion channel, score 5.8e-70 716540002188 11 transmembrane helices predicted for EAM_0427 by TMHMM2.0 at aa 479-496, 525-547, 557-579, 600-622, 632-652, 673-695, 700-722, 788-810, 830-852, 883-902 and 912-934 716540002189 Signal peptide predicted for EAM_0427 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.979 between residues 20 and 21 716540002190 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 716540002191 HMMPfam hit to PF02666, Phosphatidylserine decarboxylase, score 2.7e-105 716540002192 GTPase RsgA; Reviewed; Region: PRK12288 716540002193 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 716540002194 RNA binding site [nucleotide binding]; other site 716540002195 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 716540002196 GTPase/Zn-binding domain interface [polypeptide binding]; other site 716540002197 GTP/Mg2+ binding site [chemical binding]; other site 716540002198 G4 box; other site 716540002199 G5 box; other site 716540002200 G1 box; other site 716540002201 Switch I region; other site 716540002202 G2 box; other site 716540002203 G3 box; other site 716540002204 Switch II region; other site 716540002205 HMMPfam hit to PF03193, Protein of unknown function, DUF258, score 1.6e-142 716540002206 PS00017 ATP/GTP-binding site motif A (P-loop). 716540002207 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 716540002208 catalytic site [active] 716540002209 putative active site [active] 716540002210 putative substrate binding site [chemical binding]; other site 716540002211 dimer interface [polypeptide binding]; other site 716540002212 HMMPfam hit to PF00929, Exonuclease, score 7.4e-38 716540002213 putative carbohydrate kinase; Provisional; Region: PRK10565 716540002214 Uncharacterized conserved protein [Function unknown]; Region: COG0062 716540002215 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 716540002216 putative substrate binding site [chemical binding]; other site 716540002217 putative ATP binding site [chemical binding]; other site 716540002218 HMMPfam hit to PF03853, YjeF-related protein N-terminus, score 7.5e-56 716540002219 HMMPfam hit to PF01256, Carbohydrate kinase, score 3.2e-93 716540002220 PS00147 Arginase family signature 1. 716540002221 PS01050 Uncharacterized protein family UPF0031 signature 2. 716540002222 ADP-binding protein; Provisional; Region: PRK10646 716540002223 HMMPfam hit to PF02367, Uncharacterised P-loop hydrolase UPF0079, score 1.6e-59 716540002224 PS00017 ATP/GTP-binding site motif A (P-loop). 716540002225 Signal peptide predicted for EAM_0433 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.994 between residues 22 and 23 716540002226 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 716540002227 AMIN domain; Region: AMIN; pfam11741 716540002228 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 716540002229 active site 716540002230 metal binding site [ion binding]; metal-binding site 716540002231 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 716540002232 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 716540002233 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 716540002234 HMMPfam hit to PF01520, N-acetylmuramoyl-L-alanine amidase, score 3.3e-100 716540002235 HMMPfam hit to PF01476, LysM domain, score 1.9e-17 716540002236 HMMPfam hit to PF01476, LysM domain, score 6.2e-16 716540002237 Predicted helix-turn-helix motif with score 1474.000, SD 4.21 at aa 514-535, sequence DSLTAIAAHYGVSPQAVQQANK 716540002238 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 716540002239 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716540002240 ATP binding site [chemical binding]; other site 716540002241 Mg2+ binding site [ion binding]; other site 716540002242 G-X-G motif; other site 716540002243 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 716540002244 ATP binding site [chemical binding]; other site 716540002245 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 716540002246 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and, score 2.6e-06 716540002247 PS00058 DNA mismatch repair proteins mutL / hexB / PMS1 signature. 716540002248 HMMPfam hit to PF01119, DNA mismatch repair protein, C-termina, score 8e-40 716540002249 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 716540002250 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 716540002251 PS00017 ATP/GTP-binding site motif A (P-loop). 716540002252 HMMPfam hit to PF01715, IPP transferase, score 2.4e-150 716540002253 bacterial Hfq-like; Region: Hfq; cd01716 716540002254 hexamer interface [polypeptide binding]; other site 716540002255 Sm1 motif; other site 716540002256 RNA binding site [nucleotide binding]; other site 716540002257 Sm2 motif; other site 716540002258 HMMPfam hit to PF01423, LSM domain, score 1.2e-11 716540002259 GTPase HflX; Provisional; Region: PRK11058 716540002260 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 716540002261 HflX GTPase family; Region: HflX; cd01878 716540002262 G1 box; other site 716540002263 GTP/Mg2+ binding site [chemical binding]; other site 716540002264 Switch I region; other site 716540002265 G2 box; other site 716540002266 G3 box; other site 716540002267 Switch II region; other site 716540002268 G4 box; other site 716540002269 G5 box; other site 716540002270 HMMPfam hit to PF01926, GTPase of unknown function, score 1.2e-39 716540002271 PS00017 ATP/GTP-binding site motif A (P-loop). 716540002272 FtsH protease regulator HflK; Provisional; Region: PRK10930 716540002273 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 716540002274 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 716540002275 1 transmembrane helix predicted for EAM_0438 by TMHMM2.0 at aa 75-97 716540002276 HMMPfam hit to PF01145, SPFH domain / Band, score 8.2e-49 716540002277 FtsH protease regulator HflC; Provisional; Region: PRK11029 716540002278 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 716540002279 Signal peptide predicted for EAM_0439 by SignalP 2.0 HMM (Signal peptide probability 0.984) with cleavage site probability 0.628 between residues 23 and 24 716540002280 1 transmembrane helix predicted for EAM_0439 by TMHMM2.0 at aa 5-24 716540002281 HMMPfam hit to PF01145, SPFH domain / Band, score 4.6e-60 716540002282 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 716540002283 1 transmembrane helix predicted for EAM_0440 by TMHMM2.0 at aa 21-43 716540002284 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 716540002285 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 716540002286 GDP-binding site [chemical binding]; other site 716540002287 ACT binding site; other site 716540002288 IMP binding site; other site 716540002289 HMMPfam hit to PF00709, Adenylosuccinate synthetase, score 0 716540002290 PS01266 Adenylosuccinate synthetase GTP-binding site. 716540002291 PS00513 Adenylosuccinate synthetase active site. 716540002292 exoribonuclease R; Provisional; Region: PRK11642 716540002293 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 716540002294 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 716540002295 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 716540002296 RNB domain; Region: RNB; pfam00773 716540002297 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 716540002298 RNA binding site [nucleotide binding]; other site 716540002299 HMMPfam hit to PF08461, Ribonuclease R winged-helix domain, score 1.9e-23 716540002300 HMMPfam hit to PF08206, Ribonuclease B OB domain, score 6.5e-27 716540002301 HMMPfam hit to PF08206, Ribonuclease B OB domain, score 0.00021 716540002302 HMMPfam hit to PF00773, RNB-like protein, score 2e-106 716540002303 PS01175 Ribonuclease II family signature. 716540002304 HMMPfam hit to PF00575, S1 RNA binding domain, score 5e-19 716540002305 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 716540002306 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 716540002307 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 716540002308 HMMPfam hit to PF08032, RNA 2'-O ribose methyltransferase subs, score 2.2e-20 716540002309 HMMPfam hit to PF00588, SpoU rRNA Methylase family, score 8.9e-63 716540002310 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 716540002311 HMMPfam hit to PF07338, Protein of unknown function (DUF1471), score 1.3e-07 716540002312 Signal peptide predicted for EAM_0445 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.976 between residues 47 and 48 716540002313 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540002314 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 716540002315 dimerization interface [polypeptide binding]; other site 716540002316 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 716540002317 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 716540002318 dimer interface [polypeptide binding]; other site 716540002319 putative CheW interface [polypeptide binding]; other site 716540002320 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 1.5e-68 716540002321 HMMPfam hit to PF00672, HAMP domain, score 3.3e-13 716540002322 2 transmembrane helices predicted for EAM_0446 by TMHMM2.0 at aa 15-37 and 318-340 716540002323 Signal peptide predicted for EAM_0446 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.781 between residues 38 and 39 716540002324 esterase; Provisional; Region: PRK10566 716540002325 Bacterial sugar transferase; Region: Bac_transf; cl00939 716540002326 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 716540002327 HMMPfam hit to PF02230, Phospholipase/Carboxylesterase, score 1.5e-05 716540002328 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 716540002329 HMMPfam hit to PF01250, Ribosomal protein S6, score 8.3e-48 716540002330 PS01048 Ribosomal protein S6 signature. 716540002331 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 716540002332 dimer interface [polypeptide binding]; other site 716540002333 ssDNA binding site [nucleotide binding]; other site 716540002334 tetramer (dimer of dimers) interface [polypeptide binding]; other site 716540002335 HMMPfam hit to PF00436, Single-strand binding protein family, score 6e-17 716540002336 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 716540002337 HMMPfam hit to PF01084, Ribosomal protein S18, score 1.3e-32 716540002338 PS00057 Ribosomal protein S18 signature. 716540002339 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 716540002340 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 716540002341 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 716540002342 HMMPfam hit to PF01281, Ribosomal protein L9, N-terminal domai, score 1.3e-27 716540002343 PS00651 Ribosomal protein L9 signature. 716540002344 HMMPfam hit to PF03948, Ribosomal protein L9, C-terminal domai, score 1.5e-44 716540002345 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 716540002346 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 716540002347 HMMPfam hit to PF04225, Opacity-associated protein A LysM-like domai, score 3.1e-49 716540002348 HMMPfam hit to PF08525, Opacity-associated protein A N-terminal moti, score 1e-08 716540002349 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 716540002350 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 716540002351 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 716540002352 HMMPfam hit to PF00254, FKBP-type peptidyl-prolyl cis-trans isomeras, score 1.9e-45 716540002353 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. 716540002354 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 716540002355 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 716540002356 active site 716540002357 metal binding site [ion binding]; metal-binding site 716540002358 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 716540002359 HMMPfam hit to PF02872, 5'-nucleotidase, C-terminal domain, score 8.7e-61 716540002360 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 1.5e-15 716540002361 PS00786 5'-nucleotidase signature 2. 716540002362 Signal peptide predicted for EAM_0454 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 19 and 20 716540002363 PS00435 Peroxidases proximal heme-ligand signature. 716540002364 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 716540002365 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 716540002366 active site 716540002367 HMMPfam hit to PF00459, Inositol monophosphatase family, score 7.5e-66 716540002368 PS00629 Inositol monophosphatase family signature 1. 716540002369 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 716540002370 HMMPfam hit to PF06526, Protein of unknown function (DUF1107), score 7.8e-44 716540002371 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 716540002372 Domain of unknown function DUF21; Region: DUF21; pfam01595 716540002373 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 716540002374 Transporter associated domain; Region: CorC_HlyC; smart01091 716540002375 HMMPfam hit to PF03471, Transporter associated domain, score 2.3e-21 716540002376 HMMPfam hit to PF00571, CBS domain pair, score 2.2e-16 716540002377 HMMPfam hit to PF01595, Domain of unknown function DUF21, score 1.9e-66 716540002378 4 transmembrane helices predicted for EAM_0458 by TMHMM2.0 at aa 5-27, 57-79, 99-121 and 142-164 716540002379 Signal peptide predicted for EAM_0458 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.500 between residues 26 and 27 716540002380 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 716540002381 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 716540002382 Surface antigen; Region: Bac_surface_Ag; pfam01103 716540002383 Signal peptide predicted for EAM_0459 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.984 between residues 25 and 26 716540002384 HMMPfam hit to PF07244, Surface antigen variable number repeat, score 1.7e-09 716540002385 HMMPfam hit to PF01103, Surface antigen, score 1.4e-80 716540002386 PS00213 Lipocalin signature. 716540002387 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 716540002388 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 716540002389 Family of unknown function (DUF490); Region: DUF490; pfam04357 716540002390 Signal peptide predicted for EAM_0460 by SignalP 2.0 HMM (Signal peptide probability 0.936) with cleavage site probability 0.400 between residues 40 and 41 716540002391 1 transmembrane helix predicted for EAM_0460 by TMHMM2.0 at aa 7-29 716540002392 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540002393 PS00213 Lipocalin signature. 716540002394 HMMPfam hit to PF04357, Family of unknown function (DUF490), score 2.6e-155 716540002395 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 716540002396 putative active site pocket [active] 716540002397 dimerization interface [polypeptide binding]; other site 716540002398 putative catalytic residue [active] 716540002399 HMMPfam hit to PF03674, Uncharacterised protein family (UPF0131), score 2e-37 716540002400 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 716540002401 dimer interface [polypeptide binding]; other site 716540002402 substrate binding site [chemical binding]; other site 716540002403 metal binding sites [ion binding]; metal-binding site 716540002404 HMMPfam hit to PF00719, Inorganic pyrophosphatase, score 3.4e-57 716540002405 PS00387 Inorganic pyrophosphatase signature. 716540002406 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 716540002407 dimer interface [polypeptide binding]; other site 716540002408 ligand binding site [chemical binding]; other site 716540002409 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 716540002410 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 716540002411 dimerization interface [polypeptide binding]; other site 716540002412 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 716540002413 dimer interface [polypeptide binding]; other site 716540002414 putative CheW interface [polypeptide binding]; other site 716540002415 Signal peptide predicted for EAM_0463 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.811 between residues 29 and 30 716540002416 2 transmembrane helices predicted for EAM_0463 by TMHMM2.0 at aa 10-32 and 191-213 716540002417 HMMPfam hit to PF00672, HAMP domain, score 1.8e-14 716540002418 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 2.1e-97 716540002419 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 716540002420 AMP binding site [chemical binding]; other site 716540002421 metal binding site [ion binding]; metal-binding site 716540002422 active site 716540002423 HMMPfam hit to PF00316, Fructose-1-6-bisphosphatase, score 2.9e-207 716540002424 PS00124 Fructose-1-6-bisphosphatase active site. 716540002425 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 716540002426 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 716540002427 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 716540002428 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 716540002429 Signal peptide predicted for EAM_0465 by SignalP 2.0 HMM (Signal peptide probability 0.970) with cleavage site probability 0.849 between residues 24 and 25 716540002430 HMMPfam hit to PF01225, Mur ligase family, catalytic domain, score 5.1e-30 716540002431 HMMPfam hit to PF08245, Mur ligase middle domain, score 2.4e-08 716540002432 HMMPfam hit to PF02875, Mur ligase family, glutamate ligase doma, score 2.8e-06 716540002433 hypothetical protein; Provisional; Region: PRK05255 716540002434 HMMPfam hit to PF04751, Protein of unknown function (DUF615), score 5.5e-108 716540002435 peptidase PmbA; Provisional; Region: PRK11040 716540002436 HMMPfam hit to PF01523, modulator of DNA gyrase, score 2.1e-94 716540002437 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 716540002438 HMMPfam hit to PF00874, PRD domain, score 7.5e-10 716540002439 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; pfam14272 716540002440 Domain of unknown function (DUF4312); Region: DUF4312; pfam14189 716540002441 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 716540002442 Signal peptide predicted for EAM_0472 by SignalP 2.0 HMM (Signal peptide probability 0.907) with cleavage site probability 0.515 between residues 30 and 31 716540002443 6 transmembrane helices predicted for EAM_0472 by TMHMM2.0 at aa 2-24, 55-77, 111-133, 143-165, 177-199 and 214-232 716540002444 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 716540002445 6 transmembrane helices predicted for EAM_0473 by TMHMM2.0 at aa 15-37, 58-75, 85-107, 112-134, 161-183 and 188-210 716540002446 dihydroorotase; Provisional; Region: PRK09237 716540002447 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 716540002448 active site 716540002449 HMMPfam hit to PF01979, Amidohydrolase family, score 0.0023 716540002450 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 716540002451 catalytic residue [active] 716540002452 HMMPfam hit to PF03841, L-seryl-tRNA selenium transferase, score 7.6e-07 716540002453 HMMPfam hit to PF01212, Beta-eliminating lyase, score 0.00013 716540002454 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 716540002455 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 716540002456 HMMPfam hit to PF07071, Protein of unknown function (DUF1341), score 5e-147 716540002457 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 716540002458 HTH domain; Region: HTH_11; pfam08279 716540002459 Mga helix-turn-helix domain; Region: Mga; pfam05043 716540002460 PRD domain; Region: PRD; pfam00874 716540002461 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 716540002462 active site 716540002463 P-loop; other site 716540002464 phosphorylation site [posttranslational modification] 716540002465 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 716540002466 active site 716540002467 phosphorylation site [posttranslational modification] 716540002468 HMMPfam hit to PF08279, HTH domain, score 4.2e-13 716540002469 Predicted helix-turn-helix motif with score 1799.000, SD 5.31 at aa 20-41, sequence LPQDELARRLNVSTRTVRTDIN 716540002470 Predicted helix-turn-helix motif with score 1799.000, SD 5.31 at aa 107-41, sequence NVLNELLADYAARFVLSRSTGYQLKIDDADRFQQLIQQSPCHLRVPRNSAERINYLL TRFLTSAFSL 716540002471 HMMPfam hit to PF05043, Mga helix-turn-helix domain, score 0.00015 716540002472 HMMPfam hit to PF08279, HTH domain, score 0.0019 716540002473 Predicted helix-turn-helix motif with score 1391.000, SD 3.92 at aa 107-128, sequence LKLEDLADEWFVSRSTLQNDMA 716540002474 HMMPfam hit to PF00874, PRD domain, score 2.4e-13 716540002475 HMMPfam hit to PF00359, Phosphoenolpyruvate-dependent sugar phosph, score 0.00023 716540002476 outer membrane lipoprotein; Provisional; Region: PRK11023 716540002477 BON domain; Region: BON; pfam04972 716540002478 BON domain; Region: BON; pfam04972 716540002479 HMMPfam hit to PF04972, phospholipid-binding domain, score 5.1e-13 716540002480 HMMPfam hit to PF04972, phospholipid-binding domain, score 9e-09 716540002481 1 transmembrane helix predicted for EAM_0478 by TMHMM2.0 at aa 7-29 716540002482 Signal peptide predicted for EAM_0478 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.273 between residues 21 and 22 716540002483 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540002484 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 716540002485 dimer interface [polypeptide binding]; other site 716540002486 active site 716540002487 hypothetical protein; Reviewed; Region: PRK12497 716540002488 HMMPfam hit to PF02021, Uncharacterised protein family UPF0102, score 2.9e-35 716540002489 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 716540002490 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 716540002491 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 716540002492 putative ligand binding site [chemical binding]; other site 716540002493 HMMPfam hit to PF04348, LppC lipoprotein, score 4.6e-122 716540002494 Signal peptide predicted for EAM_0481 by SignalP 2.0 HMM (Signal peptide probability 0.991) with cleavage site probability 0.362 between residues 30 and 31 716540002495 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540002496 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 716540002497 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 716540002498 putative SAM binding site [chemical binding]; other site 716540002499 putative homodimer interface [polypeptide binding]; other site 716540002500 HMMPfam hit to PF00590, Tetrapyrrole (Corrin/Porphyrin) Methylas, score 2.6e-65 716540002501 PS01296 Uncharacterized protein family UPF0011 signature. 716540002502 Pirin-related protein [General function prediction only]; Region: COG1741 716540002503 Pirin; Region: Pirin; pfam02678 716540002504 HMMPfam hit to PF02678, Pirin, score 5.8e-31 716540002505 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716540002506 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 716540002507 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 716540002508 dimerization interface [polypeptide binding]; other site 716540002509 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 3.2e-15 716540002510 Predicted helix-turn-helix motif with score 1071.000, SD 2.83 at aa 22-43, sequence GSFAAAADELGRVPSALSYTMQ 716540002511 PS00044 Bacterial regulatory proteins, lysR family signature. 716540002512 HMMPfam hit to PF03466, LysR substrate binding domain, score 2.7e-13 716540002513 1 transmembrane helix predicted for EAM_0488 by TMHMM2.0 at aa 20-42 716540002514 Predicted membrane protein [Function unknown]; Region: COG2259 716540002515 4 transmembrane helices predicted for EAM_0490 by TMHMM2.0 at aa 9-26, 41-63, 70-88 and 103-122 716540002516 HMMPfam hit to PF07681, DoxX, score 3.5e-37 716540002517 YqjK-like protein; Region: YqjK; pfam13997 716540002518 Predicted membrane protein [Function unknown]; Region: COG5393 716540002519 2 transmembrane helices predicted for EAM_0492 by TMHMM2.0 at aa 51-73 and 83-105 716540002520 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 716540002521 HMMPfam hit to PF05957, Bacterial protein of unknown function (DUF88, score 2e-44 716540002522 1 transmembrane helix predicted for EAM_0493 by TMHMM2.0 at aa 81-98 716540002523 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 716540002524 HMMPfam hit to PF06476, Protein of unknown function (DUF1090), score 2.8e-33 716540002525 Signal peptide predicted for EAM_0494 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.970 between residues 20 and 21 716540002526 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 716540002527 Signal peptide predicted for EAM_0495 by SignalP 2.0 HMM (Signal peptide probability 0.973) with cleavage site probability 0.725 between residues 37 and 38 716540002528 1 transmembrane helix predicted for EAM_0495 by TMHMM2.0 at aa 13-35 716540002529 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 716540002530 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 716540002531 5 transmembrane helices predicted for EAM_0496 by TMHMM2.0 at aa 24-46, 53-75, 126-148, 155-175 and 190-212 716540002532 serine/threonine transporter SstT; Provisional; Region: PRK13628 716540002533 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 716540002534 HMMPfam hit to PF00375, Sodium:dicarboxylate symporter family, score 5.4e-137 716540002535 8 transmembrane helices predicted for EAM_0498 by TMHMM2.0 at aa 12-34, 49-71, 83-105, 140-162, 183-205, 215-237, 297-319 and 329-351 716540002536 PS00435 Peroxidases proximal heme-ligand signature. 716540002537 Signal peptide predicted for EAM_0498 by SignalP 2.0 HMM (Signal peptide probability 0.888) with cleavage site probability 0.565 between residues 39 and 40 716540002538 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 716540002539 9 transmembrane helices predicted for EAM_0499 by TMHMM2.0 at aa 10-29, 42-64, 88-110, 115-137, 142-161, 198-220, 235-257, 264-286 and 290-312 716540002540 HMMPfam hit to PF03741, Integral membrane protein TerC family, score 5.9e-57 716540002541 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 716540002542 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 716540002543 Cl- selectivity filter; other site 716540002544 Cl- binding residues [ion binding]; other site 716540002545 pore gating glutamate residue; other site 716540002546 dimer interface [polypeptide binding]; other site 716540002547 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 716540002548 9 transmembrane helices predicted for EAM_0500 by TMHMM2.0 at aa 13-35, 55-77, 194-216, 231-253, 265-287, 292-314, 327-349, 359-381 and 388-410 716540002549 HMMPfam hit to PF00654, Voltage gated chloride channel, score 1.2e-12 716540002550 HMMPfam hit to PF00571, CBS domain pair, score 0.00013 716540002551 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 716540002552 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 716540002553 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 716540002554 NAD(P) binding site [chemical binding]; other site 716540002555 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like domain, score 2e-39 716540002556 PS00059 Zinc-containing alcohol dehydrogenases signature. 716540002557 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 2.5e-05 716540002558 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 716540002559 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716540002560 active site 716540002561 motif I; other site 716540002562 motif II; other site 716540002563 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 2.6e-17 716540002564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540002565 Major Facilitator Superfamily; Region: MFS_1; pfam07690 716540002566 putative substrate translocation pore; other site 716540002567 12 transmembrane helices predicted for EAM_0504 by TMHMM2.0 at aa 35-52, 65-87, 94-111, 116-138, 151-173, 183-202, 214-236, 256-275, 287-304, 308-330, 343-365 and 369-391 716540002568 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 3.6e-25 716540002569 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 716540002570 HMMPfam hit to PF01863, Protein of unknown function DUF45, score 1.8e-05 716540002571 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 716540002572 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716540002573 S-adenosylmethionine binding site [chemical binding]; other site 716540002574 HMMPfam hit to PF05175, Methyltransferase small domain, score 4.2e-71 716540002575 PS00092 N-6 Adenine-specific DNA methylases signature. 716540002576 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 716540002577 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 716540002578 active site 716540002579 FMN binding site [chemical binding]; other site 716540002580 2,4-decadienoyl-CoA binding site; other site 716540002581 catalytic residue [active] 716540002582 4Fe-4S cluster binding site [ion binding]; other site 716540002583 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 716540002584 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 716540002585 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 0.0013 716540002586 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidoredu, score 0.00019 716540002587 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoredu, score 0.0052 716540002588 HMMPfam hit to PF00724, NADH:flavin oxidoreductase / NADH oxidas, score 1e-115 716540002589 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 716540002590 active site clefts [active] 716540002591 zinc binding site [ion binding]; other site 716540002592 dimer interface [polypeptide binding]; other site 716540002593 HMMPfam hit to PF00484, Carbonic anhydrase, score 1.7e-31 716540002594 PS00704 Prokaryotic-type carbonic anhydrases signature 1. 716540002595 PS00705 Prokaryotic-type carbonic anhydrases signature 2. 716540002596 high affinity sulphate transporter 1; Region: sulP; TIGR00815 716540002597 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 716540002598 Sulfate transporter family; Region: Sulfate_transp; pfam00916 716540002599 Signal peptide predicted for EAM_0511 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.978 between residues 30 and 31 716540002600 HMMPfam hit to PF00860, Permease family, score 0.0025 716540002601 9 transmembrane helices predicted for EAM_0511 by TMHMM2.0 at aa 10-29, 36-58, 78-100, 105-127, 147-169, 181-203, 287-309, 322-344 and 385-407 716540002602 HMMPfam hit to PF00916, Sulfate transporter family, score 8.8e-26 716540002603 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 716540002604 active site 716540002605 dimer interface [polypeptide binding]; other site 716540002606 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 716540002607 HMMPfam hit to PF01244, Membrane dipeptidase (Peptidase family, score 4.6e-121 716540002608 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 716540002609 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 716540002610 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 716540002611 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 716540002612 HMMPfam hit to PF03070, TENA/THI-4/PQQC family, score 1.7e-72 716540002613 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 716540002614 HMMPfam hit to PF05402, Coenzyme PQQ synthesis protein D (PqqD), score 1.4e-44 716540002615 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 716540002616 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 716540002617 FeS/SAM binding site; other site 716540002618 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 716540002619 HMMPfam hit to PF04055, Radical SAM superfamily, score 4.8e-33 716540002620 PS01305 moaA / nifB / pqqE family signature. 716540002621 coenzyme PQQ biosynthesis probable peptidase PqqF; Region: PQQ_syn_pqqF; TIGR02110 716540002622 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 716540002623 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 716540002624 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 716540002625 HMMPfam hit to PF00675, Insulinase (Peptidase family M16), score 2.2e-32 716540002626 PS00143 Insulinase family, zinc-binding region signature. 716540002627 HMMPfam hit to PF05193, Peptidase M16 inactive domain, score 8.6e-08 716540002628 PS00196 Type-1 copper (blue) proteins signature. 716540002629 Signal peptide predicted for EAM_0518 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.991 between residues 31 and 32 716540002630 1 transmembrane helix predicted for EAM_0518 by TMHMM2.0 at aa 5-27 716540002631 1 transmembrane helix predicted for EAM_0520 by TMHMM2.0 at aa 21-43 716540002632 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 716540002633 HMMPfam hit to PF03608, PTS system enzyme II sorbitol-specific facto, score 4.1e-134 716540002634 3 transmembrane helices predicted for EAM_0521 by TMHMM2.0 at aa 26-48, 68-87 and 134-156 716540002635 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 716540002636 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 716540002637 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 716540002638 HMMPfam hit to PF03612, Sorbitol phosphotransferase enzyme II N-t, score 1.4e-121 716540002639 PS00107 Protein kinases ATP-binding region signature. 716540002640 5 transmembrane helices predicted for EAM_0522 by TMHMM2.0 at aa 191-210, 214-236, 243-265, 275-297 and 309-331 716540002641 HMMPfam hit to PF07663, Sorbitol phosphotransferase enzyme II C-t, score 9.2e-54 716540002642 PTS system, glucitol/sorbitol-specific IIA component; Region: gutA; TIGR00849 716540002643 HMMPfam hit to PF03829, PTS system glucitol/sorbitol-specific IIA, score 5.1e-72 716540002644 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540002645 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 716540002646 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 716540002647 putative NAD(P) binding site [chemical binding]; other site 716540002648 active site 716540002649 HMMPfam hit to PF00106, short chain dehydrogenase, score 2e-22 716540002650 PS00061 Short-chain dehydrogenases/reductases family signature. 716540002651 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 716540002652 HMMPfam hit to PF06923, Glucitol operon activator protein (GutM), score 4.5e-64 716540002653 1 transmembrane helix predicted for EAM_0525 by TMHMM2.0 at aa 7-26 716540002654 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 716540002655 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 716540002656 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 716540002657 HMMPfam hit to PF08220, DeoR-like helix-turn-helix domain, score 2.5e-14 716540002658 HMMPfam hit to PF08279, HTH domain, score 0.00021 716540002659 PS00894 Bacterial regulatory proteins, deoR family signature. 716540002660 HMMPfam hit to PF00455, Bacterial regulatory proteins, deoR family, score 1.1e-70 716540002661 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 716540002662 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 716540002663 putative active site [active] 716540002664 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 716540002665 HMMPfam hit to PF01380, SIS domain, score 6.6e-33 716540002666 HMMPfam hit to PF00571, CBS domain pair, score 1.3e-22 716540002667 Predicted transcriptional regulator [Transcription]; Region: COG2932 716540002668 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 716540002669 HMMPfam hit to PF07022, Bacteriophage CI repressor helix-turn-h, score 3.4e-34 716540002670 Predicted helix-turn-helix motif with score 1635.000, SD 4.76 at aa 36-57, sequence TTRQALCDHLGVSQSTMANRWM 716540002671 PS00294 Prenyl group binding site (CAAX box). 716540002672 1 transmembrane helix predicted for EAM_0536 by TMHMM2.0 at aa 15-34 716540002673 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 716540002674 PLD-like domain; Region: PLDc_2; pfam13091 716540002675 putative active site [active] 716540002676 catalytic site [active] 716540002677 Signal peptide predicted for EAM_0538 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.975 between residues 18 and 19 716540002678 Cholesterol oxidase, substrate-binding; Region: Chol_subst-bind; pfam09129 716540002679 Signal peptide predicted for EAM_0544 by SignalP 2.0 HMM (Signal peptide probability 0.902) with cleavage site probability 0.677 between residues 23 and 24 716540002680 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 716540002681 HMMPfam hit to PF04606, Ogr/Delta-like zinc finger, score 2.6e-26 716540002682 PAAR motif; Region: PAAR_motif; pfam05488 716540002683 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 716540002684 PS00017 ATP/GTP-binding site motif A (P-loop). 716540002685 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 716540002686 Signal peptide predicted for EAM_0549 by SignalP 2.0 HMM (Signal peptide probability 0.991) with cleavage site probability 0.954 between residues 20 and 21 716540002687 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540002688 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 716540002689 Signal peptide predicted for EAM_0551 by SignalP 2.0 HMM (Signal peptide probability 0.991) with cleavage site probability 0.948 between residues 20 and 21 716540002690 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540002691 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 716540002692 Signal peptide predicted for EAM_0553 by SignalP 2.0 HMM (Signal peptide probability 0.991) with cleavage site probability 0.948 between residues 20 and 21 716540002693 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540002694 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 716540002695 Signal peptide predicted for EAM_0555 by SignalP 2.0 HMM (Signal peptide probability 0.991) with cleavage site probability 0.954 between residues 20 and 21 716540002696 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540002697 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540002698 metabolite-proton symporter; Region: 2A0106; TIGR00883 716540002699 putative substrate translocation pore; other site 716540002700 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.4e-20 716540002701 12 transmembrane helices predicted for EAM_0557 by TMHMM2.0 at aa 40-62, 77-99, 108-130, 140-162, 175-197, 207-226, 274-296, 306-328, 335-352, 362-384, 405-424 and 428-450 716540002702 HMMPfam hit to PF00083, Sugar (and other) transporter, score 1.7e-10 716540002703 Transcriptional regulators [Transcription]; Region: PurR; COG1609 716540002704 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 716540002705 DNA binding site [nucleotide binding] 716540002706 domain linker motif; other site 716540002707 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 716540002708 dimerization interface [polypeptide binding]; other site 716540002709 ligand binding site [chemical binding]; other site 716540002710 Predicted helix-turn-helix motif with score 1497.000, SD 4.29 at aa 9-30, sequence ATRADVAQEAGTSVAVVSYVVN 716540002711 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 1.1e-09 716540002712 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 716540002713 active site 716540002714 HMMPfam hit to PF01156, Inosine-uridine preferring nucleoside hy, score 1.5e-42 716540002715 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 716540002716 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 716540002717 6 transmembrane helices predicted for EAM_0560 by TMHMM2.0 at aa 30-52, 168-190, 211-233, 248-267, 379-401 and 432-454 716540002718 HMMPfam hit to PF03929, PepSY-associated TM helix, score 0.0032 716540002719 HMMPfam hit to PF03929, PepSY-associated TM helix, score 0.017 716540002720 HMMPfam hit to PF03929, PepSY-associated TM helix, score 0.062 716540002721 PS00017 ATP/GTP-binding site motif A (P-loop). 716540002722 Signal peptide predicted for EAM_0561 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.870 between residues 36 and 37 716540002723 1 transmembrane helix predicted for EAM_0561 by TMHMM2.0 at aa 13-35 716540002724 4 transmembrane helices predicted for EAM_0562 by TMHMM2.0 at aa 4-25, 42-64, 84-103 and 115-137 716540002725 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 716540002726 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 716540002727 metal binding site [ion binding]; metal-binding site 716540002728 active site 716540002729 I-site; other site 716540002730 HMMPfam hit to PF00990, GGDEF domain, score 1.5e-53 716540002731 5 transmembrane helices predicted for EAM_0564 by TMHMM2.0 at aa 15-37, 44-63, 73-90, 102-124 and 144-166 716540002732 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 716540002733 HMMPfam hit to PF07256, Protein of unknown function (DUF1435), score 9e-25 716540002734 Signal peptide predicted for EAM_0565 by SignalP 2.0 HMM (Signal peptide probability 0.852) with cleavage site probability 0.446 between residues 64 and 65 716540002735 3 transmembrane helices predicted for EAM_0565 by TMHMM2.0 at aa 7-24, 28-47 and 54-76 716540002736 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 716540002737 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 716540002738 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716540002739 S-adenosylmethionine binding site [chemical binding]; other site 716540002740 HMMPfam hit to PF05175, Methyltransferase small domain, score 1.3e-95 716540002741 HMMPfam hit to PF08242, Methyltransferase domain, score 8.3e-06 716540002742 HMMPfam hit to PF08468, Methyltransferase small domain N-term, score 4.2e-91 716540002743 DNA polymerase III subunit psi; Validated; Region: PRK06856 716540002744 HMMPfam hit to PF03603, DNA polymerase III psi subunit, score 2e-39 716540002745 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 716540002746 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 716540002747 HMMPfam hit to PF08445, FR47-like protein, score 9e-05 716540002748 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 6.3e-21 716540002749 dUMP phosphatase; Provisional; Region: PRK09449 716540002750 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716540002751 motif II; other site 716540002752 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 1.8e-33 716540002753 PS00761 Signal peptidases I signature 3. 716540002754 1 transmembrane helix predicted for EAM_0570 by TMHMM2.0 at aa 44-66 716540002755 Type 6 seretion system 2 716540002756 Signal peptide predicted for EAM_0571 by SignalP 2.0 HMM (Signal peptide probability 0.959) with cleavage site probability 0.506 between residues 18 and 19 716540002757 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540002758 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 716540002759 Signal peptide predicted for EAM_0572 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.420 between residues 34 and 35 716540002760 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540002761 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 716540002762 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 716540002763 HMMPfam hit to PF05936, Bacterial protein of unknown function (DUF87, score 2e-146 716540002764 hypothetical protein; Provisional; Region: PRK07033 716540002765 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 716540002766 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 716540002767 ligand binding site [chemical binding]; other site 716540002768 1 transmembrane helix predicted for EAM_0574 by TMHMM2.0 at aa 201-223 716540002769 HMMPfam hit to PF00691, OmpA family, score 1.2e-16 716540002770 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 716540002771 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 716540002772 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 716540002773 3 transmembrane helices predicted for EAM_0575 by TMHMM2.0 at aa 13-35, 50-72 and 477-499 716540002774 PS00017 ATP/GTP-binding site motif A (P-loop). 716540002775 HMMPfam hit to PF06761, ImcF-related, score 1.4e-60 716540002776 HMMPfam hit to PF06744, Protein of unknown function (DUF1215), score 3.2e-27 716540002777 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 716540002778 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 716540002779 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 716540002780 HMMPfam hit to PF06812, ImpA-related N-terminal, score 1.7e-17 716540002781 Protein of unknown function (DUF770); Region: DUF770; pfam05591 716540002782 HMMPfam hit to PF05591, Protein of unknown function (DUF770), score 1.8e-92 716540002783 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 716540002784 Protein of unknown function (DUF877); Region: DUF877; pfam05943 716540002785 HMMPfam hit to PF05943, Protein of unknown function (DUF877), score 0 716540002786 PS00213 Lipocalin signature. 716540002787 Protein of unknown function (DUF796); Region: DUF796; pfam05638 716540002788 HMMPfam hit to PF05638, Protein of unknown function (DUF796), score 5.6e-38 716540002789 Domain of unknown function (DUF4285); Region: DUF4285; pfam14113 716540002790 Signal peptide predicted for EAM_0582 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.919 between residues 22 and 23 716540002791 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 716540002792 Signal peptide predicted for EAM_0583 by SignalP 2.0 HMM (Signal peptide probability 0.818) with cleavage site probability 0.719 between residues 24 and 25 716540002793 HMMPfam hit to PF07007, Protein of unknown function (DUF1311), score 2.8e-12 716540002794 Signal peptide predicted for EAM_0584 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.850 between residues 22 and 23 716540002795 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 716540002796 phosphopeptide binding site; other site 716540002797 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 716540002798 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 716540002799 active site 716540002800 HMMPfam hit to PF00481, Protein phosphatase 2C, score 0.00018 716540002801 Signal peptide predicted for EAM_0587 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 19 and 20 716540002802 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 716540002803 ImpE protein; Region: ImpE; pfam07024 716540002804 HMMPfam hit to PF07024, ImpE protein, score 1.4e-68 716540002805 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 716540002806 HMMPfam hit to PF07025, Protein of unknown function (DUF1316), score 2.1e-33 716540002807 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 716540002808 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 716540002809 HMMPfam hit to PF05947, Bacterial protein of unknown function (DUF87, score 4e-257 716540002810 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 716540002811 HMMPfam hit to PF06996, Protein of unknown function (DUF1305), score 2.6e-101 716540002812 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 716540002813 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 716540002814 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716540002815 Walker A motif; other site 716540002816 ATP binding site [chemical binding]; other site 716540002817 Walker B motif; other site 716540002818 arginine finger; other site 716540002819 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716540002820 Walker A motif; other site 716540002821 ATP binding site [chemical binding]; other site 716540002822 Walker B motif; other site 716540002823 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 716540002824 HMMPfam hit to PF02861, Clp amino terminal domain, score 9.8e-05 716540002825 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 3.3e-08 716540002826 PS00017 ATP/GTP-binding site motif A (P-loop). 716540002827 PS00870 Chaperonins clpA/B signature 1. 716540002828 HMMPfam hit to PF07724, ATPase family associated with various cellul, score 1.1e-87 716540002829 HMMPfam hit to PF07728, ATPase family associated with various cellul, score 0.00012 716540002830 PS00017 ATP/GTP-binding site motif A (P-loop). 716540002831 Protein kinase domain; Region: Pkinase; pfam00069 716540002832 Catalytic domain of Protein Kinases; Region: PKc; cd00180 716540002833 active site 716540002834 ATP binding site [chemical binding]; other site 716540002835 substrate binding site [chemical binding]; other site 716540002836 activation loop (A-loop); other site 716540002837 HMMPfam hit to PF00069, Protein kinase domain, score 5.3e-10 716540002838 PS00107 Protein kinases ATP-binding region signature. 716540002839 PS00107 Protein kinases ATP-binding region signature. 716540002840 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 716540002841 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 716540002842 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 716540002843 HMMPfam hit to PF04524, Protein of unknown function, DUF586, score 1.1e-52 716540002844 PAAR motif; Region: PAAR_motif; pfam05488 716540002845 HMMPfam hit to PF05488, PAAR motif, score 1.1e-06 716540002846 HMMPfam hit to PF05488, PAAR motif, score 3.6e-05 716540002847 4 transmembrane helices predicted for EAM_0596 by TMHMM2.0 at aa 3-18, 28-50, 71-93 and 121-143 716540002848 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 716540002849 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 716540002850 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 716540002851 HMMPfam hit to PF04524, Protein of unknown function, DUF586, score 1.1e-52 716540002852 Domain of unknown function (DUF1795); Region: DUF1795; cl02256 716540002853 PAAR motif; Region: PAAR_motif; pfam05488 716540002854 RHS Repeat; Region: RHS_repeat; pfam05593 716540002855 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 716540002856 RHS Repeat; Region: RHS_repeat; pfam05593 716540002857 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 716540002858 RHS Repeat; Region: RHS_repeat; cl11982 716540002859 RHS Repeat; Region: RHS_repeat; pfam05593 716540002860 RHS Repeat; Region: RHS_repeat; cl11982 716540002861 RHS Repeat; Region: RHS_repeat; cl11982 716540002862 RHS protein; Region: RHS; pfam03527 716540002863 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 716540002864 2 transmembrane helices predicted for EAM_0600 by TMHMM2.0 at aa 15-37 and 44-66 716540002865 HMMPfam hit to PF05488, PAAR motif, score 0.92 716540002866 HMMPfam hit to PF05488, PAAR motif, score 5.6e-05 716540002867 HMMPfam hit to PF05593, RHS Repeat, score 0.17 716540002868 HMMPfam hit to PF05593, RHS Repeat, score 0.0093 716540002869 HMMPfam hit to PF05593, RHS Repeat, score 0.058 716540002870 HMMPfam hit to PF05593, RHS Repeat, score 0.54 716540002871 HMMPfam hit to PF05593, RHS Repeat, score 2.7e-06 716540002872 HMMPfam hit to PF05593, RHS Repeat, score 0.00019 716540002873 HMMPfam hit to PF05593, RHS Repeat, score 2.2 716540002874 HMMPfam hit to PF05593, RHS Repeat, score 9.5e-07 716540002875 HMMPfam hit to PF05593, RHS Repeat, score 0.089 716540002876 HMMPfam hit to PF05593, RHS Repeat, score 7.3 716540002877 HMMPfam hit to PF05593, RHS Repeat, score 0.00011 716540002878 HMMPfam hit to PF05593, RHS Repeat, score 3.7 716540002879 HMMPfam hit to PF05593, RHS Repeat, score 0.11 716540002880 HMMPfam hit to PF05593, RHS Repeat, score 0.0062 716540002881 HMMPfam hit to PF05593, RHS Repeat, score 0.0028 716540002882 PS00175 Phosphoglycerate mutase family phosphohistidine signature. 716540002883 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 716540002884 HMMPfam hit to PF00593, TonB dependent receptor, score 9.1e-09 716540002885 PS00017 ATP/GTP-binding site motif A (P-loop). 716540002886 C-terminal region of Pasteurella multocida toxin residues 569-1285; Region: PMT_C; pfam11647 716540002887 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 716540002888 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 716540002889 HMMPfam hit to PF03747, ADP-ribosylglycohydrolase, score 2.1e-50 716540002890 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 716540002891 HMMPfam hit to PF03352, Methyladenine glycosylase, score 9.1e-77 716540002892 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 716540002893 HMMPfam hit to PF01757, Acyltransferase family, score 3.8e-17 716540002894 7 transmembrane helices predicted for EAM_0609 by TMHMM2.0 at aa 72-94, 107-129, 159-181, 188-206, 248-267, 274-296 and 349-366 716540002895 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 716540002896 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 716540002897 G1 box; other site 716540002898 putative GEF interaction site [polypeptide binding]; other site 716540002899 GTP/Mg2+ binding site [chemical binding]; other site 716540002900 Switch I region; other site 716540002901 G2 box; other site 716540002902 G3 box; other site 716540002903 Switch II region; other site 716540002904 G4 box; other site 716540002905 G5 box; other site 716540002906 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 716540002907 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 4.7e-62 716540002908 PS00301 GTP-binding elongation factors signature. 716540002909 HMMPfam hit to PF03144, Elongation factor Tu domain, score 1.1e-12 716540002910 periplasmic protein; Provisional; Region: PRK10568 716540002911 BON domain; Region: BON; pfam04972 716540002912 Signal peptide predicted for EAM_0611 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 26 and 27 716540002913 HMMPfam hit to PF04972, phospholipid-binding domain, score 9.4e-15 716540002914 HMMPfam hit to PF04972, phospholipid-binding domain, score 3.1e-16 716540002915 Signal peptide predicted for EAM_0612 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.926 between residues 30 and 31 716540002916 HMMPfam hit to PF07043, Protein of unknown function (DUF1328), score 1.6e-19 716540002917 2 transmembrane helices predicted for EAM_0612 by TMHMM2.0 at aa 5-23 and 27-49 716540002918 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 716540002919 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 716540002920 active site 716540002921 nucleophile elbow; other site 716540002922 HMMPfam hit to PF01734, Patatin-like phospholipase, score 1.3e-22 716540002923 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 716540002924 active site 716540002925 HMMPfam hit to PF01026, TatD related DNase, score 3.4e-93 716540002926 PS01137 Uncharacterized protein family UPF0006 signature 1. 716540002927 PS01090 Uncharacterized protein family UPF0006 signature 2. 716540002928 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 716540002929 intersubunit interface [polypeptide binding]; other site 716540002930 active site 716540002931 catalytic residue [active] 716540002932 HMMPfam hit to PF01791, DeoC/LacD family aldolase, score 8e-76 716540002933 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 716540002934 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 716540002935 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 716540002936 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 716540002937 HMMPfam hit to PF02885, Glycosyl transferase family, helical, score 1e-25 716540002938 HMMPfam hit to PF00591, Glycosyl transferase family, a/b doma, score 2.8e-70 716540002939 PS00647 Thymidine and pyrimidine-nucleoside phosphorylases signature. 716540002940 HMMPfam hit to PF07831, Pyrimidine nucleoside phosphorylase C, score 2.2e-29 716540002941 phosphopentomutase; Provisional; Region: PRK05362 716540002942 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 716540002943 HMMPfam hit to PF08342, Phosphopentomutase N-terminal, score 5.1e-69 716540002944 HMMPfam hit to PF01676, Metalloenzyme superfamily, score 7.1e-40 716540002945 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 716540002946 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 716540002947 HMMPfam hit to PF01048, Phosphorylase family, score 2.8e-113 716540002948 PS01232 Purine and other phosphorylases family 1 signature. 716540002949 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 716540002950 HipA-like C-terminal domain; Region: HipA_C; pfam07804 716540002951 Predicted helix-turn-helix motif with score 1530.000, SD 4.40 at aa 13-34, sequence LDAASLQARLGVSQATLSRLIK 716540002952 HMMPfam hit to PF07805, HipA-like N-terminal domain, score 1.4e-20 716540002953 HMMPfam hit to PF07804, HipA-like C-terminal domain, score 2.7e-08 716540002954 hypothetical protein; Provisional; Region: PRK11246 716540002955 2 transmembrane helices predicted for EAM_0620 by TMHMM2.0 at aa 13-35 and 162-184 716540002956 Signal peptide predicted for EAM_0620 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.564 between residues 41 and 42 716540002957 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 716540002958 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716540002959 motif II; other site 716540002960 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 8.9e-27 716540002961 HMMPfam hit to PF08282, haloacid dehalogenase-like hydrolase, score 0.00085 716540002962 DNA repair protein RadA; Region: sms; TIGR00416 716540002963 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 716540002964 Walker A motif/ATP binding site; other site 716540002965 ATP binding site [chemical binding]; other site 716540002966 Walker B motif; other site 716540002967 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 716540002968 PS00190 Cytochrome c family heme-binding site signature. 716540002969 PS00017 ATP/GTP-binding site motif A (P-loop). 716540002970 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 716540002971 non-specific DNA binding site [nucleotide binding]; other site 716540002972 salt bridge; other site 716540002973 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 716540002974 sequence-specific DNA binding site [nucleotide binding]; other site 716540002975 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 716540002976 active site 716540002977 (T/H)XGH motif; other site 716540002978 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 716540002979 HMMPfam hit to PF01381, Helix-turn-helix, score 1.2e-07 716540002980 Predicted helix-turn-helix motif with score 1877.000, SD 5.58 at aa 16-37, sequence CTLQQVADASGMTKGYLSQLLN 716540002981 PS00017 ATP/GTP-binding site motif A (P-loop). 716540002982 PS00687 Aldehyde dehydrogenases glutamic acid active site. 716540002983 Signal peptide predicted for EAM_0624 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.276 between residues 33 and 34 716540002984 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540002985 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 716540002986 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 716540002987 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 716540002988 Signal peptide predicted for EAM_0625 by SignalP 2.0 HMM (Signal peptide probability 0.909) with cleavage site probability 0.842 between residues 25 and 26 716540002989 HMMPfam hit to PF08479, POTRA domain, ShlB-type, score 8.7e-13 716540002990 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 716540002991 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 716540002992 putative NAD(P) binding site [chemical binding]; other site 716540002993 dimer interface [polypeptide binding]; other site 716540002994 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 8.2e-09 716540002995 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like domain, score 1.8e-08 716540002996 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716540002997 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716540002998 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 716540002999 putative effector binding pocket; other site 716540003000 dimerization interface [polypeptide binding]; other site 716540003001 Signal peptide predicted for EAM_0627 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.244 between residues 24 and 25 716540003002 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 4.5e-18 716540003003 Predicted helix-turn-helix motif with score 1558.000, SD 4.49 at aa 19-40, sequence GSFTAAATRAGLPKSSVSQRIN 716540003004 PS00044 Bacterial regulatory proteins, lysR family signature. 716540003005 HMMPfam hit to PF03466, LysR substrate binding domain, score 5.6e-41 716540003006 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 716540003007 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 716540003008 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 716540003009 ABC transporter; Region: ABC_tran_2; pfam12848 716540003010 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 716540003011 HMMPfam hit to PF00005, ABC transporter, score 4.3e-55 716540003012 PS00017 ATP/GTP-binding site motif A (P-loop). 716540003013 HMMPfam hit to PF00005, ABC transporter, score 7e-59 716540003014 PS00211 ABC transporters family signature. 716540003015 PS00017 ATP/GTP-binding site motif A (P-loop). 716540003016 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540003017 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 716540003018 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 716540003019 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 716540003020 HMMPfam hit to PF00455, Bacterial regulatory proteins, deoR family, score 2.6e-48 716540003021 HMMPfam hit to PF08220, DeoR-like helix-turn-helix domain, score 8.6e-11 716540003022 Predicted helix-turn-helix motif with score 1809.000, SD 5.35 at aa 22-43, sequence MHLKEAARLLAVSEMTIRRDLN 716540003023 PS00894 Bacterial regulatory proteins, deoR family signature. 716540003024 Amidase; Region: Amidase; cl11426 716540003025 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540003026 lytic murein transglycosylase; Provisional; Region: PRK11619 716540003027 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 716540003028 N-acetyl-D-glucosamine binding site [chemical binding]; other site 716540003029 catalytic residue [active] 716540003030 Signal peptide predicted for EAM_0633 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.986 between residues 27 and 28 716540003031 HMMPfam hit to PF01464, Transglycosylase SLT domain, score 3e-40 716540003032 PS00922 Prokaryotic transglycosylases signature. 716540003033 Trp operon repressor; Provisional; Region: PRK01381 716540003034 HMMPfam hit to PF01371, Trp repressor protein, score 4.2e-40 716540003035 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 716540003036 HMMPfam hit to PF01931, Protein of unknown function DUF84, score 1.3e-65 716540003037 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 716540003038 catalytic core [active] 716540003039 HMMPfam hit to PF00300, Phosphoglycerate mutase family, score 4.4e-50 716540003040 PS00175 Phosphoglycerate mutase family phosphohistidine signature. 716540003041 1 transmembrane helix predicted for EAM_0636 by TMHMM2.0 at aa 146-168 716540003042 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 716540003043 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716540003044 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 716540003045 HMMPfam hit to PF06445, Bacterial transcription activator, effect, score 7.1e-20 716540003046 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix pro, score 1e-09 716540003047 PS00041 Bacterial regulatory proteins, araC family signature. 716540003048 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix pro, score 6.4e-12 716540003049 Predicted helix-turn-helix motif with score 1159.000, SD 3.13 at aa 22-43, sequence LSLDNVAAKAGYSKWHLQRMFK 716540003050 hypothetical protein; Provisional; Region: PRK10756 716540003051 CreA protein; Region: CreA; pfam05981 716540003052 Signal peptide predicted for EAM_0639 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.582 between residues 21 and 22 716540003053 HMMPfam hit to PF05981, CreA protein, score 1.2e-87 716540003054 two-component response regulator; Provisional; Region: PRK11173 716540003055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716540003056 active site 716540003057 phosphorylation site [posttranslational modification] 716540003058 intermolecular recognition site; other site 716540003059 dimerization interface [polypeptide binding]; other site 716540003060 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 716540003061 DNA binding site [nucleotide binding] 716540003062 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 4.1e-18 716540003063 HMMPfam hit to PF00072, Response regulator receiver domain, score 1e-32 716540003064 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 716540003065 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 716540003066 putative catalytic residues [active] 716540003067 putative nucleotide binding site [chemical binding]; other site 716540003068 putative aspartate binding site [chemical binding]; other site 716540003069 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 716540003070 dimer interface [polypeptide binding]; other site 716540003071 putative threonine allosteric regulatory site; other site 716540003072 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 716540003073 putative threonine allosteric regulatory site; other site 716540003074 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 716540003075 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 716540003076 HMMPfam hit to PF00696, Amino acid kinase family, score 4.6e-61 716540003077 PS00324 Aspartokinase signature. 716540003078 HMMPfam hit to PF01842, ACT domain, score 2.2e-08 716540003079 HMMPfam hit to PF01842, ACT domain, score 5.2e-08 716540003080 HMMPfam hit to PF03447, Homoserine dehydrogenase, NAD binding d, score 1.6e-37 716540003081 HMMPfam hit to PF00742, Homoserine dehydrogenase, score 4e-98 716540003082 PS01042 Homoserine dehydrogenase signature. 716540003083 homoserine kinase; Provisional; Region: PRK01212 716540003084 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 716540003085 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 716540003086 HMMPfam hit to PF00288, GHMP kinases N terminal domain, score 4.6e-21 716540003087 PS00627 GHMP kinases ATP-binding domain. 716540003088 HMMPfam hit to PF08544, GHMP kinases C terminal, score 4.5e-08 716540003089 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 716540003090 threonine synthase; Validated; Region: PRK09225 716540003091 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 716540003092 catalytic residue [active] 716540003093 HMMPfam hit to PF00291, Pyridoxal-phosphate dependent enzyme, score 3e-35 716540003094 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 716540003095 hypothetical protein; Validated; Region: PRK02101 716540003096 HMMPfam hit to PF03883, Protein of unknown function (DUF328), score 6.6e-171 716540003097 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 716540003098 transaldolase-like protein; Provisional; Region: PTZ00411 716540003099 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 716540003100 active site 716540003101 dimer interface [polypeptide binding]; other site 716540003102 catalytic residue [active] 716540003103 HMMPfam hit to PF00923, Transaldolase, score 5.6e-182 716540003104 PS01054 Transaldolase signature 1. 716540003105 PS00958 Transaldolase active site. 716540003106 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 716540003107 MPT binding site; other site 716540003108 trimer interface [polypeptide binding]; other site 716540003109 HMMPfam hit to PF00994, molybdopterin binding domain, score 1.9e-31 716540003110 PS01078 Molybdenum cofactor biosynthesis proteins signature 1. 716540003111 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 716540003112 HMMPfam hit to PF01757, Acyltransferase family, score 2.8e-20 716540003113 10 transmembrane helices predicted for EAM_0648 by TMHMM2.0 at aa 13-35, 40-62, 83-105, 152-174, 179-198, 208-225, 232-251, 256-273, 305-327 and 337-359 716540003114 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 716540003115 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 716540003116 nucleotide binding site [chemical binding]; other site 716540003117 HMMPfam hit to PF00012, Hsp70 protein, score 0 716540003118 PS00297 Heat shock hsp70 proteins family signature 1. 716540003119 PS00329 Heat shock hsp70 proteins family signature 2. 716540003120 PS01036 Heat shock hsp70 proteins family signature 3. 716540003121 chaperone protein DnaJ; Provisional; Region: PRK10767 716540003122 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 716540003123 HSP70 interaction site [polypeptide binding]; other site 716540003124 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 716540003125 substrate binding site [polypeptide binding]; other site 716540003126 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 716540003127 Zn binding sites [ion binding]; other site 716540003128 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 716540003129 dimer interface [polypeptide binding]; other site 716540003130 HMMPfam hit to PF00226, DnaJ domain, score 9.3e-37 716540003131 PS00636 Nt-dnaJ domain signature. 716540003132 HMMPfam hit to PF00684, DnaJ central domain (4 repeats), score 6.5e-46 716540003133 PS00637 CXXCXGXG dnaJ domain signature. 716540003134 PS00190 Cytochrome c family heme-binding site signature. 716540003135 PS00190 Cytochrome c family heme-binding site signature. 716540003136 PS00190 Cytochrome c family heme-binding site signature. 716540003137 HMMPfam hit to PF01556, DnaJ C terminal region, score 1.3e-76 716540003138 1 transmembrane helix predicted for EAM_0651 by TMHMM2.0 at aa 15-37 716540003139 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 716540003140 Signal peptide predicted for EAM_0652 by SignalP 2.0 HMM (Signal peptide probability 0.981) with cleavage site probability 0.519 between residues 32 and 33 716540003141 HMMPfam hit to PF06965, Na+/H+ antiporter, score 1e-226 716540003142 11 transmembrane helices predicted for EAM_0652 by TMHMM2.0 at aa 13-30, 60-77, 97-116, 126-148, 155-177, 181-203, 216-238, 258-280, 285-307, 329-351 and 358-380 716540003143 PS00044 Bacterial regulatory proteins, lysR family signature. 716540003144 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 716540003145 HMMPfam hit to PF01649, Ribosomal protein S20, score 1.6e-44 716540003146 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 716540003147 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 716540003148 active site 716540003149 Riboflavin kinase; Region: Flavokinase; smart00904 716540003150 HMMPfam hit to PF06574, FAD synthetase, score 2.9e-81 716540003151 HMMPfam hit to PF01467, Cytidylyltransferase, score 0.0082 716540003152 HMMPfam hit to PF01687, Riboflavin kinase, score 4.7e-66 716540003153 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 716540003154 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 716540003155 active site 716540003156 HIGH motif; other site 716540003157 nucleotide binding site [chemical binding]; other site 716540003158 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 716540003159 active site 716540003160 KMSKS motif; other site 716540003161 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 716540003162 tRNA binding surface [nucleotide binding]; other site 716540003163 anticodon binding site; other site 716540003164 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 716540003165 HMMPfam hit to PF00133, tRNA synthetases class I (I, L, M and V), score 0 716540003166 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 716540003167 HMMPfam hit to PF08264, Anticodon-binding domain, score 1.4e-58 716540003168 HMMPfam hit to PF06827, Zinc finger found in FPG and IleRS, score 3e-11 716540003169 Signal peptide predicted for EAM_0656 by SignalP 2.0 HMM (Signal peptide probability 0.615) with cleavage site probability 0.396 between residues 26 and 27 716540003170 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 716540003171 lipoprotein signal peptidase; Provisional; Region: PRK14787 716540003172 HMMPfam hit to PF01252, Signal peptidase (SPase) II, score 5.1e-74 716540003173 4 transmembrane helices predicted for EAM_0656 by TMHMM2.0 at aa 13-32, 68-87, 100-122 and 137-159 716540003174 PS00855 Signal peptidases II signature. 716540003175 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 716540003176 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 716540003177 HMMPfam hit to PF00254, FKBP-type peptidyl-prolyl cis-trans isomeras, score 2.3e-05 716540003178 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. 716540003179 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 716540003180 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 716540003181 HMMPfam hit to PF02401, LytB protein, score 1.6e-178 716540003182 dihydrodipicolinate reductase; Provisional; Region: PRK00048 716540003183 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 716540003184 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 716540003185 HMMPfam hit to PF01113, Dihydrodipicolinate reductase, N-terminus, score 1.1e-66 716540003186 HMMPfam hit to PF05173, Dihydrodipicolinate reductase, C-terminus, score 8.5e-78 716540003187 PS01298 Dihydrodipicolinate reductase signature. 716540003188 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 716540003189 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 716540003190 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 716540003191 catalytic site [active] 716540003192 subunit interface [polypeptide binding]; other site 716540003193 HMMPfam hit to PF00988, Carbamoyl-phosphate synthase small ch, score 1.6e-92 716540003194 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 4.9e-74 716540003195 PS00442 Glutamine amidotransferases class-I active site. 716540003196 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 716540003197 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 716540003198 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 716540003199 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 716540003200 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 716540003201 ATP-grasp domain; Region: ATP-grasp_4; cl17255 716540003202 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 716540003203 IMP binding site; other site 716540003204 dimer interface [polypeptide binding]; other site 716540003205 interdomain contacts; other site 716540003206 partial ornithine binding site; other site 716540003207 Signal peptide predicted for EAM_0661 by SignalP 2.0 HMM (Signal peptide probability 0.767) with cleavage site probability 0.700 between residues 23 and 24 716540003208 HMMPfam hit to PF00289, Carbamoyl-phosphate synthase L chain,, score 5.6e-64 716540003209 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540003210 HMMPfam hit to PF02786, Carbamoyl-phosphate synthase L chain,, score 7.3e-144 716540003211 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 716540003212 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 716540003213 HMMPfam hit to PF02787, Carbamoyl-phosphate synthetase large c, score 2.4e-63 716540003214 HMMPfam hit to PF00289, Carbamoyl-phosphate synthase L chain,, score 1.3e-26 716540003215 HMMPfam hit to PF02655, ATP-grasp domain, score 0.0013 716540003216 HMMPfam hit to PF02786, Carbamoyl-phosphate synthase L chain,, score 3.7e-27 716540003217 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 716540003218 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 716540003219 PS00017 ATP/GTP-binding site motif A (P-loop). 716540003220 HMMPfam hit to PF02142, MGS-like domain, score 1.2e-34 716540003221 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 716540003222 HMMPfam hit to PF01810, LysE type translocator, score 9.9e-32 716540003223 5 transmembrane helices predicted for EAM_0662 by TMHMM2.0 at aa 5-27, 43-65, 69-91, 117-139 and 149-171 716540003224 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 716540003225 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 716540003226 folate binding site [chemical binding]; other site 716540003227 NADP+ binding site [chemical binding]; other site 716540003228 HMMPfam hit to PF00186, Dihydrofolate reductase, score 2.9e-61 716540003229 PS00075 Dihydrofolate reductase signature. 716540003230 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 716540003231 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 716540003232 active site 716540003233 metal binding site [ion binding]; metal-binding site 716540003234 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 1.6e-17 716540003235 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 716540003236 HMMPfam hit to PF04379, Protein of unknown function (DUF525), score 6.7e-66 716540003237 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 716540003238 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716540003239 S-adenosylmethionine binding site [chemical binding]; other site 716540003240 HMMPfam hit to PF00398, Ribosomal RNA adenine dimethylase, score 2.1e-95 716540003241 PS01131 Ribosomal RNA adenine dimethylases signature. 716540003242 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 716540003243 HMMPfam hit to PF04166, Pyridoxal phosphate biosynthetic protein Pdx, score 3.5e-163 716540003244 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 716540003245 SurA N-terminal domain; Region: SurA_N; pfam09312 716540003246 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 716540003247 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 716540003248 HMMPfam hit to PF00639, PPIC-type PPIASE domain, score 3e-39 716540003249 PS01096 PpiC-type peptidyl-prolyl cis-trans isomerase signature. 716540003250 HMMPfam hit to PF00639, PPIC-type PPIASE domain, score 2.8e-37 716540003251 PS01096 PpiC-type peptidyl-prolyl cis-trans isomerase signature. 716540003252 Signal peptide predicted for EAM_0668 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 20 and 21 716540003253 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 716540003254 OstA-like protein; Region: OstA; pfam03968 716540003255 Organic solvent tolerance protein; Region: OstA_C; pfam04453 716540003256 HMMPfam hit to PF04453, Organic solvent tolerance protein, score 4.6e-127 716540003257 HMMPfam hit to PF03968, OstA-like protein, score 1.4e-54 716540003258 Signal peptide predicted for EAM_0669 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.987 between residues 24 and 25 716540003259 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 716540003260 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 716540003261 putative metal binding site [ion binding]; other site 716540003262 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 716540003263 HSP70 interaction site [polypeptide binding]; other site 716540003264 Signal peptide predicted for EAM_0670 by SignalP 2.0 HMM (Signal peptide probability 0.745) with cleavage site probability 0.441 between residues 22 and 23 716540003265 1 transmembrane helix predicted for EAM_0670 by TMHMM2.0 at aa 7-29 716540003266 Predicted helix-turn-helix motif with score 988.000, SD 2.55 at aa 153-174, sequence QVLYVIAEELGISRTQFDQFLR 716540003267 HMMPfam hit to PF00226, DnaJ domain, score 1.2e-05 716540003268 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 716540003269 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 716540003270 active site 716540003271 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 6e-58 716540003272 PS01129 Rlu family of pseudouridine synthase signature. 716540003273 ATP-dependent helicase HepA; Validated; Region: PRK04914 716540003274 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 716540003275 ATP binding site [chemical binding]; other site 716540003276 putative Mg++ binding site [ion binding]; other site 716540003277 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 716540003278 nucleotide binding region [chemical binding]; other site 716540003279 ATP-binding site [chemical binding]; other site 716540003280 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 9.5e-19 716540003281 HMMPfam hit to PF00176, SNF2 family N-terminal domain, score 3.6e-71 716540003282 HMMPfam hit to PF04851, Type III restriction enzyme, res subunit, score 1.8e-06 716540003283 DNA polymerase II; Reviewed; Region: PRK05762 716540003284 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 716540003285 active site 716540003286 catalytic site [active] 716540003287 substrate binding site [chemical binding]; other site 716540003288 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 716540003289 active site 716540003290 metal-binding site 716540003291 HMMPfam hit to PF00136, DNA polymerase family B, score 2e-27 716540003292 PS00116 DNA polymerase family B signature. 716540003293 HMMPfam hit to PF03104, DNA polymerase family B, exonuclease do, score 2.7e-36 716540003294 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 716540003295 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 716540003296 5 transmembrane helices predicted for EAM_0674 by TMHMM2.0 at aa 13-35, 55-77, 144-166, 176-198 and 219-241 716540003297 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 716540003298 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716540003299 Walker A/P-loop; other site 716540003300 ATP binding site [chemical binding]; other site 716540003301 Q-loop/lid; other site 716540003302 ABC transporter signature motif; other site 716540003303 Walker B; other site 716540003304 D-loop; other site 716540003305 H-loop/switch region; other site 716540003306 HMMPfam hit to PF00005, ABC transporter, score 4.3e-64 716540003307 PS00211 ABC transporters family signature. 716540003308 PS00017 ATP/GTP-binding site motif A (P-loop). 716540003309 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 716540003310 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540003311 dimer interface [polypeptide binding]; other site 716540003312 conserved gate region; other site 716540003313 putative PBP binding loops; other site 716540003314 ABC-ATPase subunit interface; other site 716540003315 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540003316 dimer interface [polypeptide binding]; other site 716540003317 conserved gate region; other site 716540003318 putative PBP binding loops; other site 716540003319 ABC-ATPase subunit interface; other site 716540003320 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 0.0012 716540003321 11 transmembrane helices predicted for EAM_0676 by TMHMM2.0 at aa 13-35, 60-82, 95-117, 137-159, 196-218, 238-260, 289-311, 331-353, 373-395, 462-484 and 504-526 716540003322 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 4.3e-06 716540003323 Predicted helix-turn-helix motif with score 1137.000, SD 3.06 at aa 167-188, sequence TEQRQLAAQLGLSGWWHFRIVE 716540003324 Signal peptide predicted for EAM_0676 by SignalP 2.0 HMM (Signal peptide probability 0.916) with cleavage site probability 0.305 between residues 40 and 41 716540003325 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 716540003326 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 716540003327 Signal peptide predicted for EAM_0677 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.901 between residues 18 and 19 716540003328 transcriptional regulator SgrR; Provisional; Region: PRK13626 716540003329 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 716540003330 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 716540003331 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 6.2e-42 716540003332 Predicted helix-turn-helix motif with score 1469.000, SD 4.19 at aa 24-45, sequence TTLSDLAVQLSCSRRHMRNLLN 716540003333 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540003334 sugar efflux transporter; Region: 2A0120; TIGR00899 716540003335 putative substrate translocation pore; other site 716540003336 Signal peptide predicted for EAM_0679 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.671 between residues 30 and 31 716540003337 12 transmembrane helices predicted for EAM_0679 by TMHMM2.0 at aa 13-32, 47-69, 81-100, 105-127, 148-166, 170-192, 220-242, 252-274, 281-303, 307-329, 342-361 and 365-387 716540003338 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 3.8e-32 716540003339 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 716540003340 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 716540003341 substrate binding site [chemical binding]; other site 716540003342 HMMPfam hit to PF00694, Aconitase C-terminal domain, score 8.8e-53 716540003343 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 716540003344 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 716540003345 substrate binding site [chemical binding]; other site 716540003346 ligand binding site [chemical binding]; other site 716540003347 HMMPfam hit to PF00330, Aconitase family (aconitate hydratase), score 4.8e-263 716540003348 PS01244 Aconitase family signature 2. 716540003349 PS00450 Aconitase family signature 1. 716540003350 PS00017 ATP/GTP-binding site motif A (P-loop). 716540003351 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 716540003352 tartrate dehydrogenase; Provisional; Region: PRK08194 716540003353 HMMPfam hit to PF00180, Isocitrate/isopropylmalate dehydrogenase, score 1.8e-219 716540003354 PS00470 Isocitrate and isopropylmalate dehydrogenases signature. 716540003355 2-isopropylmalate synthase; Validated; Region: PRK00915 716540003356 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 716540003357 active site 716540003358 catalytic residues [active] 716540003359 metal binding site [ion binding]; metal-binding site 716540003360 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 716540003361 HMMPfam hit to PF08502, LeuA allosteric (dimerisation) domain, score 2.1e-59 716540003362 HMMPfam hit to PF00682, HMGL-like, score 2.1e-146 716540003363 PS00816 Alpha-isopropylmalate and homocitrate synthases signature 2. 716540003364 PS00815 Alpha-isopropylmalate and homocitrate synthases signature 1. 716540003365 HMMPfam hit to PF08054, Leucine operon leader peptide, score 1.9e-06 716540003366 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 716540003367 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 716540003368 PYR/PP interface [polypeptide binding]; other site 716540003369 dimer interface [polypeptide binding]; other site 716540003370 TPP binding site [chemical binding]; other site 716540003371 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 716540003372 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 716540003373 TPP-binding site [chemical binding]; other site 716540003374 dimer interface [polypeptide binding]; other site 716540003375 HMMPfam hit to PF02776, Thiamine pyrophosphate enzyme, N-termina, score 2e-101 716540003376 PS00044 Bacterial regulatory proteins, lysR family signature. 716540003377 HMMPfam hit to PF00205, Thiamine pyrophosphate enzyme, central d, score 8.7e-73 716540003378 HMMPfam hit to PF02775, Thiamine pyrophosphate enzyme, C-termina, score 3.8e-75 716540003379 PS00187 Thiamine pyrophosphate enzymes signature. 716540003380 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 716540003381 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 716540003382 putative valine binding site [chemical binding]; other site 716540003383 dimer interface [polypeptide binding]; other site 716540003384 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 716540003385 PS00430 TonB-dependent receptor proteins signature 1. 716540003386 HMMPfam hit to PF01842, ACT domain, score 1.1e-16 716540003387 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 716540003388 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 716540003389 DNA binding site [nucleotide binding] 716540003390 domain linker motif; other site 716540003391 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 716540003392 dimerization interface [polypeptide binding]; other site 716540003393 ligand binding site [chemical binding]; other site 716540003394 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 1.6e-08 716540003395 Predicted helix-turn-helix motif with score 1821.000, SD 5.39 at aa 1-22, sequence MKLDEIARLAGVSRTTASYVIN 716540003396 PS00356 Bacterial regulatory proteins, lacI family signature. 716540003397 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 7.1e-07 716540003398 cell division protein MraZ; Reviewed; Region: PRK00326 716540003399 MraZ protein; Region: MraZ; pfam02381 716540003400 MraZ protein; Region: MraZ; pfam02381 716540003401 HMMPfam hit to PF02381, MraZ protein, score 8.1e-27 716540003402 HMMPfam hit to PF02381, MraZ protein, score 1.3e-24 716540003403 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 716540003404 MraW methylase family; Region: Methyltransf_5; pfam01795 716540003405 HMMPfam hit to PF01795, MraW methylase family, score 2.8e-185 716540003406 cell division protein FtsL; Provisional; Region: PRK10772 716540003407 HMMPfam hit to PF04999, Cell division protein FtsL, score 1.1e-54 716540003408 1 transmembrane helix predicted for EAM_0691 by TMHMM2.0 at aa 20-42 716540003409 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 716540003410 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 716540003411 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 716540003412 Signal peptide predicted for EAM_0692 by SignalP 2.0 HMM (Signal peptide probability 0.909) with cleavage site probability 0.506 between residues 45 and 46 716540003413 1 transmembrane helix predicted for EAM_0692 by TMHMM2.0 at aa 21-43 716540003414 HMMPfam hit to PF03717, Penicillin-binding Protein dimerisatio, score 2e-65 716540003415 HMMPfam hit to PF00905, Penicillin binding protein transpeptid, score 1.2e-109 716540003416 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 716540003417 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 716540003418 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 716540003419 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 716540003420 HMMPfam hit to PF01225, Mur ligase family, catalytic domain, score 1.8e-15 716540003421 HMMPfam hit to PF08245, Mur ligase middle domain, score 1.7e-72 716540003422 HMMPfam hit to PF02875, Mur ligase family, glutamate ligase doma, score 2.1e-37 716540003423 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 716540003424 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 716540003425 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 716540003426 HMMPfam hit to PF01225, Mur ligase family, catalytic domain, score 2.5e-21 716540003427 HMMPfam hit to PF08245, Mur ligase middle domain, score 9.8e-70 716540003428 HMMPfam hit to PF02875, Mur ligase family, glutamate ligase doma, score 8.6e-12 716540003429 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 716540003430 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 716540003431 Mg++ binding site [ion binding]; other site 716540003432 putative catalytic motif [active] 716540003433 putative substrate binding site [chemical binding]; other site 716540003434 10 transmembrane helices predicted for EAM_0695 by TMHMM2.0 at aa 15-37, 75-92, 97-114, 134-151, 171-193, 200-219, 234-256, 263-285, 289-311 and 338-357 716540003435 HMMPfam hit to PF00953, Glycosyl transferase family, score 5.7e-88 716540003436 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 716540003437 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 716540003438 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 716540003439 1 transmembrane helix predicted for EAM_0696 by TMHMM2.0 at aa 9-31 716540003440 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540003441 HMMPfam hit to PF08245, Mur ligase middle domain, score 7e-59 716540003442 PS00012 Phosphopantetheine attachment site. 716540003443 HMMPfam hit to PF02875, Mur ligase family, glutamate ligase doma, score 1.3e-15 716540003444 cell division protein FtsW; Provisional; Region: PRK10774 716540003445 HMMPfam hit to PF01098, Cell cycle protein, score 9.5e-177 716540003446 8 transmembrane helices predicted for EAM_0697 by TMHMM2.0 at aa 39-61, 76-93, 100-122, 174-196, 209-231, 297-319, 331-353 and 363-385 716540003447 PS00428 Cell cycle proteins ftsW / rodA / spoVE signature. 716540003448 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 716540003449 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 716540003450 active site 716540003451 homodimer interface [polypeptide binding]; other site 716540003452 HMMPfam hit to PF03033, Glycosyltransferase family, score 5.6e-55 716540003453 HMMPfam hit to PF04101, Glycosyltransferase family, score 1.2e-52 716540003454 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 716540003455 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 716540003456 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 716540003457 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 716540003458 HMMPfam hit to PF01225, Mur ligase family, catalytic domain, score 5.6e-47 716540003459 HMMPfam hit to PF08245, Mur ligase middle domain, score 1.9e-35 716540003460 HMMPfam hit to PF02875, Mur ligase family, glutamate ligase doma, score 4e-24 716540003461 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 716540003462 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 716540003463 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 716540003464 HMMPfam hit to PF01820, D-ala D-ala ligase N-terminus, score 3.2e-45 716540003465 PS00843 D-alanine--D-alanine ligase signature 1. 716540003466 HMMPfam hit to PF07478, D-ala D-ala ligase C-terminus, score 3.8e-101 716540003467 PS00844 D-alanine--D-alanine ligase signature 2. 716540003468 cell division protein FtsQ; Provisional; Region: PRK10775 716540003469 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 716540003470 Cell division protein FtsQ; Region: FtsQ; pfam03799 716540003471 1 transmembrane helix predicted for EAM_0701 by TMHMM2.0 at aa 26-48 716540003472 HMMPfam hit to PF08478, POTRA domain, FtsQ-type, score 2.5e-23 716540003473 HMMPfam hit to PF03799, Cell division protein FtsQ, score 3.1e-27 716540003474 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 716540003475 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 716540003476 Cell division protein FtsA; Region: FtsA; pfam14450 716540003477 HMMPfam hit to PF02491, Cell division protein FtsA, score 4.2e-79 716540003478 HMMPfam hit to PF02491, Cell division protein FtsA, score 1.1e-77 716540003479 cell division protein FtsZ; Validated; Region: PRK09330 716540003480 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 716540003481 nucleotide binding site [chemical binding]; other site 716540003482 SulA interaction site; other site 716540003483 HMMPfam hit to PF00091, Tubulin/FtsZ family, GTPase domain, score 2.3e-93 716540003484 PS01134 FtsZ protein signature 1. 716540003485 PS01135 FtsZ protein signature 2. 716540003486 HMMPfam hit to PF03953, Tubulin/FtsZ family, C-terminal domain, score 1e-42 716540003487 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 716540003488 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 716540003489 HMMPfam hit to PF03331, UDP-3-O-acyl N-acetylglycosamine deacetylase, score 2.1e-187 716540003490 Protein of unknown function (DUF721); Region: DUF721; cl02324 716540003491 SecA regulator SecM; Provisional; Region: PRK02943 716540003492 Signal peptide predicted for EAM_0706 by SignalP 2.0 HMM (Signal peptide probability 0.990) with cleavage site probability 0.967 between residues 36 and 37 716540003493 HMMPfam hit to PF06558, Secretion monitor precursor protein (SecM), score 2.5e-49 716540003494 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 716540003495 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 716540003496 SEC-C motif; Region: SEC-C; pfam02810 716540003497 HMMPfam hit to PF07517, SecA DEAD-like domain, score 7.5e-215 716540003498 HMMPfam hit to PF01043, SecA preprotein cross-linking domain, score 1.7e-81 716540003499 PS01312 Protein secA signatures. 716540003500 HMMPfam hit to PF07516, SecA Wing and Scaffold domain, score 2.3e-120 716540003501 HMMPfam hit to PF02810, SEC-C motif, score 3.9e-11 716540003502 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 716540003503 Chitin binding domain; Region: Chitin_bind_3; pfam03067 716540003504 HMMPfam hit to PF03067, Chitin binding domain, score 7.1e-33 716540003505 1 transmembrane helix predicted for EAM_0709 by TMHMM2.0 at aa 7-26 716540003506 Signal peptide predicted for EAM_0709 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.990 between residues 22 and 23 716540003507 Type II secretion system 716540003508 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 716540003509 Signal peptide predicted for EAM_0710 by SignalP 2.0 HMM (Signal peptide probability 0.913) with cleavage site probability 0.517 between residues 24 and 25 716540003510 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540003511 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 716540003512 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 716540003513 6 transmembrane helices predicted for EAM_0711 by TMHMM2.0 at aa 5-27, 94-116, 136-155, 162-184, 204-226 and 239-261 716540003514 HMMPfam hit to PF01478, Type IV leader peptidase family, score 2.6e-24 716540003515 HMMPfam hit to PF06750, Bacterial Peptidase A24 N-terminal doma, score 6.7e-36 716540003516 Signal peptide predicted for EAM_0712 by SignalP 2.0 HMM (Signal peptide probability 0.961) with cleavage site probability 0.593 between residues 35 and 36 716540003517 1 transmembrane helix predicted for EAM_0712 by TMHMM2.0 at aa 18-35 716540003518 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 716540003519 GspL periplasmic domain; Region: GspL_C; cl14909 716540003520 HMMPfam hit to PF05134, General secretion pathway protein L (GspL), score 8.5e-19 716540003521 1 transmembrane helix predicted for EAM_0713 by TMHMM2.0 at aa 216-238 716540003522 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 716540003523 1 transmembrane helix predicted for EAM_0714 by TMHMM2.0 at aa 7-29 716540003524 Signal peptide predicted for EAM_0714 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.375 between residues 26 and 27 716540003525 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 716540003526 type II secretion system protein J; Region: gspJ; TIGR01711 716540003527 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 716540003528 1 transmembrane helix predicted for EAM_0715 by TMHMM2.0 at aa 7-29 716540003529 HMMPfam hit to PF07963, Prokaryotic N-terminal methylation motif, score 2.1e-09 716540003530 PS00409 Prokaryotic N-terminal methylation site. 716540003531 type II secretion system protein I; Region: gspI; TIGR01707 716540003532 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 716540003533 HMMPfam hit to PF02501, Bacterial type II secretion system protein I, score 6.4e-34 716540003534 HMMPfam hit to PF07963, Prokaryotic N-terminal methylation motif, score 3.3e-07 716540003535 Signal peptide predicted for EAM_0716 by SignalP 2.0 HMM (Signal peptide probability 0.959) with cleavage site probability 0.726 between residues 26 and 27 716540003536 1 transmembrane helix predicted for EAM_0716 by TMHMM2.0 at aa 7-26 716540003537 PS00409 Prokaryotic N-terminal methylation site. 716540003538 PS00017 ATP/GTP-binding site motif A (P-loop). 716540003539 1 transmembrane helix predicted for EAM_0717 by TMHMM2.0 at aa 7-29 716540003540 Signal peptide predicted for EAM_0717 by SignalP 2.0 HMM (Signal peptide probability 0.983) with cleavage site probability 0.573 between residues 28 and 29 716540003541 HMMPfam hit to PF07963, Prokaryotic N-terminal methylation motif, score 0.007 716540003542 PS00409 Prokaryotic N-terminal methylation site. 716540003543 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 716540003544 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 716540003545 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 716540003546 HMMPfam hit to PF08334, Bacterial type II secretion system protein G, score 1e-62 716540003547 HMMPfam hit to PF07963, Prokaryotic N-terminal methylation motif, score 7.4e-08 716540003548 1 transmembrane helix predicted for EAM_0718 by TMHMM2.0 at aa 12-34 716540003549 PS00409 Prokaryotic N-terminal methylation site. 716540003550 type II secretion system protein F; Region: GspF; TIGR02120 716540003551 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 716540003552 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 716540003553 3 transmembrane helices predicted for EAM_0719 by TMHMM2.0 at aa 167-189, 217-239 and 372-394 716540003554 HMMPfam hit to PF00482, Bacterial type II secretion system protein F, score 2.2e-19 716540003555 HMMPfam hit to PF00482, Bacterial type II secretion system protein F, score 3.5e-21 716540003556 PS00874 Bacterial type II secretion system protein F signature. 716540003557 type II secretion system protein E; Region: type_II_gspE; TIGR02533 716540003558 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 716540003559 Walker A motif; other site 716540003560 ATP binding site [chemical binding]; other site 716540003561 Walker B motif; other site 716540003562 HMMPfam hit to PF00437, Type II/IV secretion system protein, score 6.5e-148 716540003563 PS00662 Bacterial type II secretion system protein E signature. 716540003564 PS00017 ATP/GTP-binding site motif A (P-loop). 716540003565 type II secretion system protein D; Region: type_II_gspD; TIGR02517 716540003566 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 716540003567 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 716540003568 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 716540003569 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 716540003570 HMMPfam hit to PF00263, Bacterial type II and III secretion system, score 1.9e-83 716540003571 PS00875 Bacterial type II secretion system protein D signature. 716540003572 HMMPfam hit to PF03958, Bacterial type II/III secretion system sho, score 6.8e-07 716540003573 HMMPfam hit to PF03958, Bacterial type II/III secretion system sho, score 5.4e-08 716540003574 HMMPfam hit to PF03958, Bacterial type II/III secretion system sho, score 6.1e-10 716540003575 Signal peptide predicted for EAM_0721 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 31 and 32 716540003576 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 716540003577 Signal peptide predicted for EAM_0722 by SignalP 2.0 HMM (Signal peptide probability 0.829) with cleavage site probability 0.429 between residues 26 and 27 716540003578 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 716540003579 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 716540003580 active site 716540003581 8-oxo-dGMP binding site [chemical binding]; other site 716540003582 nudix motif; other site 716540003583 metal binding site [ion binding]; metal-binding site 716540003584 HMMPfam hit to PF00293, NUDIX domain, score 3.1e-27 716540003585 PS00893 mutT domain signature. 716540003586 Domain of unknown function (DUF329); Region: DUF329; cl01144 716540003587 HMMPfam hit to PF03884, Domain of unknown function (DUF329), score 1.1e-33 716540003588 hypothetical protein; Provisional; Region: PRK05287 716540003589 HMMPfam hit to PF07072, Protein of unknown function (DUF1342), score 5e-138 716540003590 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 716540003591 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 716540003592 CoA-binding site [chemical binding]; other site 716540003593 ATP-binding [chemical binding]; other site 716540003594 HMMPfam hit to PF01121, Dephospho-CoA kinase, score 1.4e-96 716540003595 PS01294 Uncharacterized protein family UPF0038 signature. 716540003596 PS00017 ATP/GTP-binding site motif A (P-loop). 716540003597 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 716540003598 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 716540003599 active site 716540003600 HMMPfam hit to PF00478, IMP dehydrogenase / GMP reductase domain, score 6.8e-151 716540003601 PS00487 IMP dehydrogenase / GMP reductase signature. 716540003602 type IV pilin biogenesis protein; Provisional; Region: PRK10573 716540003603 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 716540003604 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 716540003605 2 transmembrane helices predicted for EAM_0729 by TMHMM2.0 at aa 164-186 and 370-392 716540003606 HMMPfam hit to PF00482, Bacterial type II secretion system protein F, score 1.8e-16 716540003607 HMMPfam hit to PF00482, Bacterial type II secretion system protein F, score 2.2e-21 716540003608 PS00874 Bacterial type II secretion system protein F signature. 716540003609 hypothetical protein; Provisional; Region: PRK10436 716540003610 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 716540003611 Walker A motif; other site 716540003612 ATP binding site [chemical binding]; other site 716540003613 Walker B motif; other site 716540003614 PS00124 Fructose-1-6-bisphosphatase active site. 716540003615 HMMPfam hit to PF00437, Type II/IV secretion system protein, score 2.2e-117 716540003616 PS00662 Bacterial type II secretion system protein E signature. 716540003617 PS00017 ATP/GTP-binding site motif A (P-loop). 716540003618 putative major pilin subunit; Provisional; Region: PRK10574 716540003619 1 transmembrane helix predicted for EAM_0731 by TMHMM2.0 at aa 7-29 716540003620 HMMPfam hit to PF07963, Prokaryotic N-terminal methylation motif, score 1.9e-09 716540003621 PS00409 Prokaryotic N-terminal methylation site. 716540003622 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 716540003623 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 716540003624 amidase catalytic site [active] 716540003625 Zn binding residues [ion binding]; other site 716540003626 substrate binding site [chemical binding]; other site 716540003627 HMMPfam hit to PF01510, N-acetylmuramoyl-L-alanine amidase, score 6.8e-64 716540003628 regulatory protein AmpE; Provisional; Region: PRK10987 716540003629 4 transmembrane helices predicted for EAM_0736 by TMHMM2.0 at aa 44-66, 71-93, 146-168 and 266-283 716540003630 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 716540003631 outer membrane protease; Reviewed; Region: PRK10993 716540003632 HMMPfam hit to PF01278, Omptin family, score 1.7e-87 716540003633 Signal peptide predicted for EAM_0740 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.662 between residues 22 and 23 716540003634 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 716540003635 outer membrane protease; Reviewed; Region: PRK10993 716540003636 HMMPfam hit to PF01278, Omptin family, score 1.6e-86 716540003637 Signal peptide predicted for EAM_0742 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.662 between residues 22 and 23 716540003638 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 716540003639 active site 716540003640 HMMPfam hit to PF04616, Glycosyl hydrolases family, score 6.3e-88 716540003641 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 716540003642 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540003643 putative substrate translocation pore; other site 716540003644 12 transmembrane helices predicted for EAM_0744 by TMHMM2.0 at aa 12-34, 39-61, 82-99, 109-131, 152-174, 184-201, 234-256, 266-288, 295-317, 322-344, 365-387 and 407-429 716540003645 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.1e-08 716540003646 aromatic amino acid transporter; Provisional; Region: PRK10238 716540003647 HMMPfam hit to PF00324, Amino acid permease, score 3.4e-165 716540003648 12 transmembrane helices predicted for EAM_0745 by TMHMM2.0 at aa 20-42, 46-65, 85-107, 117-139, 152-174, 197-219, 239-261, 281-303, 330-352, 356-378, 398-420 and 425-444 716540003649 PS00218 Amino acid permeases signature. 716540003650 Signal peptide predicted for EAM_0745 by SignalP 2.0 HMM (Signal peptide probability 0.840) with cleavage site probability 0.403 between residues 41 and 42 716540003651 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 716540003652 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 716540003653 DNA-binding site [nucleotide binding]; DNA binding site 716540003654 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 716540003655 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR family, score 1.4e-26 716540003656 PS00043 Bacterial regulatory proteins, gntR family signature. 716540003657 Predicted helix-turn-helix motif with score 1302.000, SD 3.62 at aa 35-56, sequence LPERELALQFDVSRPSLREAIQ 716540003658 HMMPfam hit to PF07729, FCD domain, score 3.6e-34 716540003659 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 716540003660 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 716540003661 dimer interface [polypeptide binding]; other site 716540003662 TPP-binding site [chemical binding]; other site 716540003663 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 716540003664 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 716540003665 E3 interaction surface; other site 716540003666 lipoyl attachment site [posttranslational modification]; other site 716540003667 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 716540003668 E3 interaction surface; other site 716540003669 lipoyl attachment site [posttranslational modification]; other site 716540003670 e3 binding domain; Region: E3_binding; pfam02817 716540003671 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 716540003672 HMMPfam hit to PF00364, Biotin-requiring enzyme, score 7.1e-26 716540003673 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 716540003674 HMMPfam hit to PF00364, Biotin-requiring enzyme, score 6.2e-28 716540003675 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 716540003676 HMMPfam hit to PF02817, e3 binding domain, score 1.2e-15 716540003677 HMMPfam hit to PF00198, 2-oxoacid dehydrogenases acyltransferas, score 1.3e-109 716540003678 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 716540003679 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 716540003680 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 716540003681 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 716540003682 Signal peptide predicted for EAM_0749 by SignalP 2.0 HMM (Signal peptide probability 0.782) with cleavage site probability 0.617 between residues 25 and 26 716540003683 HMMPfam hit to PF01134, Glucose inhibited division protein A, score 0.00035 716540003684 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidored, score 2.9e-74 716540003685 PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 716540003686 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidored, score 3.6e-25 716540003687 HMMPfam hit to PF02852, Pyridine nucleotide-disulphide oxidored, score 2.1e-52 716540003688 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 716540003689 classical (c) SDRs; Region: SDR_c; cd05233 716540003690 NAD(P) binding site [chemical binding]; other site 716540003691 active site 716540003692 HMMPfam hit to PF00106, short chain dehydrogenase, score 9.2e-30 716540003693 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase family, score 0.00058 716540003694 PS00061 Short-chain dehydrogenases/reductases family signature. 716540003695 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 716540003696 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 716540003697 Walker A/P-loop; other site 716540003698 ATP binding site [chemical binding]; other site 716540003699 Q-loop/lid; other site 716540003700 ABC transporter signature motif; other site 716540003701 Walker B; other site 716540003702 D-loop; other site 716540003703 H-loop/switch region; other site 716540003704 HMMPfam hit to PF00005, ABC transporter, score 4.5e-47 716540003705 PS00017 ATP/GTP-binding site motif A (P-loop). 716540003706 PS00211 ABC transporters family signature. 716540003707 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 716540003708 HMMPfam hit to PF02361, Cobalt transport protein, score 5.6e-21 716540003709 5 transmembrane helices predicted for EAM_0752 by TMHMM2.0 at aa 10-32, 39-57, 67-84, 89-111 and 131-153 716540003710 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 716540003711 Signal peptide predicted for EAM_0753 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.848 between residues 31 and 32 716540003712 5 transmembrane helices predicted for EAM_0753 by TMHMM2.0 at aa 10-32, 53-75, 80-102, 115-137 and 147-169 716540003713 HMMPfam hit to PF02632, BioY family, score 2.2e-31 716540003714 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 716540003715 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 716540003716 NADP binding site [chemical binding]; other site 716540003717 dimer interface [polypeptide binding]; other site 716540003718 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 1.2e-06 716540003719 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like domain, score 3.4e-15 716540003720 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 716540003721 active site 716540003722 HMMPfam hit to PF03061, Thioesterase superfamily, score 1.3e-07 716540003723 acyl-CoA synthetase; Validated; Region: PRK07638 716540003724 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 716540003725 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 716540003726 acyl-activating enzyme (AAE) consensus motif; other site 716540003727 acyl-activating enzyme (AAE) consensus motif; other site 716540003728 AMP binding site [chemical binding]; other site 716540003729 active site 716540003730 CoA binding site [chemical binding]; other site 716540003731 HMMPfam hit to PF00501, AMP-binding enzyme, score 1.9e-60 716540003732 PS00455 AMP-binding domain signature. 716540003733 Predicted helix-turn-helix motif with score 1014.000, SD 2.64 at aa 446-467, sequence LPQQSAARLAKYKRPRHYYQIT 716540003734 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 716540003735 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 716540003736 dimer interface [polypeptide binding]; other site 716540003737 active site 716540003738 HMMPfam hit to PF00108, Thiolase, N-terminal domain, score 4.4e-70 716540003739 PS00139 Eukaryotic thiol (cysteine) proteases cysteine active site. 716540003740 HMMPfam hit to PF02803, Thiolase, C-terminal domain, score 8.1e-30 716540003741 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 716540003742 PS00737 Thiolases signature 2. 716540003743 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 716540003744 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 716540003745 substrate binding site [chemical binding]; other site 716540003746 oxyanion hole (OAH) forming residues; other site 716540003747 trimer interface [polypeptide binding]; other site 716540003748 HMMPfam hit to PF00378, Enoyl-CoA hydratase/isomerase family, score 1.7e-40 716540003749 PS00166 Enoyl-CoA hydratase/isomerase signature. 716540003750 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 716540003751 HMMPfam hit to PF00975, Thioesterase domain, score 9.2e-07 716540003752 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716540003753 Coenzyme A binding pocket [chemical binding]; other site 716540003754 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1.6e-07 716540003755 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 716540003756 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 716540003757 active site 716540003758 iron coordination sites [ion binding]; other site 716540003759 substrate binding pocket [chemical binding]; other site 716540003760 HMMPfam hit to PF02668, Taurine catabolism dioxygenase TauD, TfdA fa, score 3e-39 716540003761 CRISPR-associated protein 716540003762 helicase Cas3; Provisional; Region: PRK09694 716540003763 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 716540003764 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 716540003765 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 6.4e-05 716540003766 PS00017 ATP/GTP-binding site motif A (P-loop). 716540003767 Cascade antiviral complex protein; Validated; Region: PRK09693 716540003768 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09670 716540003769 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 716540003770 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 716540003771 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 716540003772 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 716540003773 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 716540003774 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540003775 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 716540003776 1 transmembrane helix predicted for EAM_0770 by TMHMM2.0 at aa 5-27 716540003777 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540003778 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 716540003779 DNA binding site [nucleotide binding] 716540003780 1 transmembrane helix predicted for EAM_0771 by TMHMM2.0 at aa 134-156 716540003781 HMMPfam hit to PF00486, Transcriptional regulatory protein, C ter, score 5.6e-11 716540003782 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 716540003783 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 716540003784 substrate binding site [chemical binding]; other site 716540003785 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 716540003786 substrate binding site [chemical binding]; other site 716540003787 ligand binding site [chemical binding]; other site 716540003788 HMMPfam hit to PF06434, Aconitate hydratase, score 6.8e-283 716540003789 HMMPfam hit to PF00330, Aconitase family (aconitate hydratase), score 1.1e-10 716540003790 PS00450 Aconitase family signature 1. 716540003791 PS01244 Aconitase family signature 2. 716540003792 hypothetical protein; Provisional; Region: PRK05248 716540003793 HMMPfam hit to PF06062, Uncharacterised protein family (UPF0231), score 5.6e-67 716540003794 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 716540003795 HMMPfam hit to PF02675, S-adenosylmethionine decarboxylase, score 6.9e-78 716540003796 spermidine synthase; Provisional; Region: PRK00811 716540003797 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716540003798 S-adenosylmethionine binding site [chemical binding]; other site 716540003799 HMMPfam hit to PF01564, Spermine/spermidine synthase, score 2.2e-124 716540003800 PS01330 Spermidine/spermine synthases family signature. 716540003801 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 716540003802 Signal peptide predicted for EAM_0776 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.804 between residues 22 and 23 716540003803 multicopper oxidase; Provisional; Region: PRK10965 716540003804 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 716540003805 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 716540003806 Signal peptide predicted for EAM_0777 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.990 between residues 28 and 29 716540003807 HMMPfam hit to PF07732, Multicopper oxidase, score 1.1e-37 716540003808 HMMPfam hit to PF07731, Multicopper oxidase, score 7.5e-22 716540003809 PS00080 Multicopper oxidases signature 2. 716540003810 2 transmembrane helices predicted for EAM_0779 by TMHMM2.0 at aa 20-42 and 52-74 716540003811 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 716540003812 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 716540003813 DNA binding residues [nucleotide binding] 716540003814 dimerization interface [polypeptide binding]; other site 716540003815 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR family, score 1.9e-06 716540003816 methionine gamma-lyase; Validated; Region: PRK07049 716540003817 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 716540003818 homodimer interface [polypeptide binding]; other site 716540003819 substrate-cofactor binding pocket; other site 716540003820 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716540003821 catalytic residue [active] 716540003822 HMMPfam hit to PF01053, Cys/Met metabolism PLP-dependent enzy, score 9.2e-103 716540003823 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 716540003824 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 716540003825 active site 716540003826 HMMPfam hit to PF00156, Phosphoribosyl transferase domain, score 4.3e-37 716540003827 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 716540003828 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 716540003829 active site clefts [active] 716540003830 zinc binding site [ion binding]; other site 716540003831 dimer interface [polypeptide binding]; other site 716540003832 HMMPfam hit to PF00484, Carbonic anhydrase, score 1.4e-58 716540003833 PS00705 Prokaryotic-type carbonic anhydrases signature 2. 716540003834 PS00704 Prokaryotic-type carbonic anhydrases signature 1. 716540003835 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 716540003836 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 716540003837 Walker A/P-loop; other site 716540003838 ATP binding site [chemical binding]; other site 716540003839 Q-loop/lid; other site 716540003840 ABC transporter signature motif; other site 716540003841 Walker B; other site 716540003842 D-loop; other site 716540003843 H-loop/switch region; other site 716540003844 HMMPfam hit to PF00005, ABC transporter, score 7.9e-53 716540003845 PS00017 ATP/GTP-binding site motif A (P-loop). 716540003846 PS00211 ABC transporters family signature. 716540003847 inner membrane transport permease; Provisional; Region: PRK15066 716540003848 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 716540003849 HMMPfam hit to PF01061, ABC-2 type transporter, score 1.6e-48 716540003850 6 transmembrane helices predicted for EAM_0786 by TMHMM2.0 at aa 20-42, 62-84, 105-127, 142-164, 171-193 and 226-248 716540003851 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 716540003852 tetramerization interface [polypeptide binding]; other site 716540003853 active site 716540003854 HMMPfam hit to PF02261, Aspartate decarboxylase, score 1.7e-78 716540003855 Pantoate-beta-alanine ligase; Region: PanC; cd00560 716540003856 pantoate--beta-alanine ligase; Region: panC; TIGR00018 716540003857 active site 716540003858 ATP-binding site [chemical binding]; other site 716540003859 pantoate-binding site; other site 716540003860 HXXH motif; other site 716540003861 HMMPfam hit to PF02569, Pantoate-beta-alanine ligase, score 4.3e-146 716540003862 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 716540003863 oligomerization interface [polypeptide binding]; other site 716540003864 active site 716540003865 metal binding site [ion binding]; metal-binding site 716540003866 HMMPfam hit to PF02548, Ketopantoate hydroxymethyltransferase, score 3.7e-166 716540003867 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 716540003868 catalytic center binding site [active] 716540003869 ATP binding site [chemical binding]; other site 716540003870 HMMPfam hit to PF01288, 7,8-dihydro-6-hydroxymethylpterin-pyrophosph, score 4.6e-65 716540003871 PS00794 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature. 716540003872 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 716540003873 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 716540003874 active site 716540003875 NTP binding site [chemical binding]; other site 716540003876 metal binding triad [ion binding]; metal-binding site 716540003877 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 716540003878 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 716540003879 HMMPfam hit to PF01743, Poly A polymerase family, score 3e-68 716540003880 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 716540003881 glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838 716540003882 active site 716540003883 nucleotide binding site [chemical binding]; other site 716540003884 HIGH motif; other site 716540003885 KMSKS motif; other site 716540003886 HMMPfam hit to PF00749, tRNA synthetases class I (E and Q), cata, score 3.3e-29 716540003887 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 716540003888 HMMPfam hit to PF01258, Prokaryotic dksA/traR C4-type zinc finge, score 6.2e-36 716540003889 PS01102 Prokaryotic dksA/traR C4-type zinc finger. 716540003890 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 716540003891 HMMPfam hit to PF03749, Sugar fermentation stimulation protein, score 2.9e-111 716540003892 2'-5' RNA ligase; Provisional; Region: PRK15124 716540003893 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 716540003894 HMMPfam hit to PF02834, 2',5' RNA ligase family, score 1.2e-09 716540003895 HMMPfam hit to PF02834, 2',5' RNA ligase family, score 8.5e-14 716540003896 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 716540003897 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 716540003898 ATP binding site [chemical binding]; other site 716540003899 putative Mg++ binding site [ion binding]; other site 716540003900 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 716540003901 nucleotide binding region [chemical binding]; other site 716540003902 ATP-binding site [chemical binding]; other site 716540003903 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 716540003904 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 716540003905 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 2.3e-08 716540003906 PS00017 ATP/GTP-binding site motif A (P-loop). 716540003907 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 4.8e-12 716540003908 HMMPfam hit to PF04408, Helicase associated domain (HA2), score 6.8e-06 716540003909 HMMPfam hit to PF08482, ATP-dependent helicase C-terminal, score 3.2e-88 716540003910 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 716540003911 Transglycosylase; Region: Transgly; pfam00912 716540003912 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 716540003913 1 transmembrane helix predicted for EAM_0797 by TMHMM2.0 at aa 65-87 716540003914 HMMPfam hit to PF00912, Transglycosylase, score 1.7e-82 716540003915 HMMPfam hit to PF00905, Penicillin binding protein transpeptid, score 5.3e-16 716540003916 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 716540003917 PAAR motif; Region: PAAR_motif; pfam05488 716540003918 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 716540003919 RHS Repeat; Region: RHS_repeat; pfam05593 716540003920 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 716540003921 RHS Repeat; Region: RHS_repeat; pfam05593 716540003922 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 716540003923 RHS Repeat; Region: RHS_repeat; cl11982 716540003924 RHS protein; Region: RHS; pfam03527 716540003925 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 716540003926 2 transmembrane helices predicted for EAM_0799 by TMHMM2.0 at aa 15-37 and 42-64 716540003927 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540003928 HMMPfam hit to PF05488, PAAR motif, score 6.7e-05 716540003929 HMMPfam hit to PF05488, PAAR motif, score 5e-08 716540003930 HMMPfam hit to PF05593, RHS Repeat, score 0.0071 716540003931 HMMPfam hit to PF05593, RHS Repeat, score 3.7e-05 716540003932 HMMPfam hit to PF05593, RHS Repeat, score 1.6e-05 716540003933 HMMPfam hit to PF05593, RHS Repeat, score 1.9e-08 716540003934 HMMPfam hit to PF05593, RHS Repeat, score 0.33 716540003935 HMMPfam hit to PF05593, RHS Repeat, score 6.5e-07 716540003936 HMMPfam hit to PF05593, RHS Repeat, score 0.0025 716540003937 HMMPfam hit to PF05593, RHS Repeat, score 0.014 716540003938 HMMPfam hit to PF05593, RHS Repeat, score 0.023 716540003939 HMMPfam hit to PF05593, RHS Repeat, score 0.027 716540003940 HMMPfam hit to PF05593, RHS Repeat, score 0.028 716540003941 HMMPfam hit to PF05593, RHS Repeat, score 0.29 716540003942 HMMPfam hit to PF05593, RHS Repeat, score 0.98 716540003943 Uncharacterized protein At1g47420; Region: PLN02749 716540003944 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 716540003945 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 716540003946 HMMPfam hit to PF04221, RelB antitoxin, score 1.3e-05 716540003947 PS00215 Mitochondrial energy transfer proteins signature. 716540003948 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 716540003949 HMMPfam hit to PF05016, Plasmid stabilisation system protein, score 2.1e-07 716540003950 Signal peptide predicted for EAM_0805 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 36 and 37 716540003951 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 3.6e-23 716540003952 HMMPfam hit to PF00593, TonB dependent receptor, score 4.3e-18 716540003953 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 716540003954 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 716540003955 Walker A/P-loop; other site 716540003956 ATP binding site [chemical binding]; other site 716540003957 Q-loop/lid; other site 716540003958 ABC transporter signature motif; other site 716540003959 Walker B; other site 716540003960 D-loop; other site 716540003961 H-loop/switch region; other site 716540003962 HMMPfam hit to PF00005, ABC transporter, score 5.2e-57 716540003963 PS00017 ATP/GTP-binding site motif A (P-loop). 716540003964 PS00211 ABC transporters family signature. 716540003965 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 716540003966 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 716540003967 siderophore binding site; other site 716540003968 Signal peptide predicted for EAM_0807 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 28 and 29 716540003969 HMMPfam hit to PF01497, Periplasmic binding protein, score 1.8e-06 716540003970 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 716540003971 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 716540003972 ABC-ATPase subunit interface; other site 716540003973 dimer interface [polypeptide binding]; other site 716540003974 putative PBP binding regions; other site 716540003975 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 716540003976 ABC-ATPase subunit interface; other site 716540003977 dimer interface [polypeptide binding]; other site 716540003978 putative PBP binding regions; other site 716540003979 Signal peptide predicted for EAM_0808 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.791 between residues 21 and 22 716540003980 18 transmembrane helices predicted for EAM_0808 by TMHMM2.0 at aa 5-27, 56-78, 90-112, 116-138, 145-167, 192-214, 235-257, 272-290, 302-324, 348-370, 395-417, 421-443, 448-470, 480-502, 532-554, 569-591, 612-634 and 638-656 716540003981 HMMPfam hit to PF01032, FecCD transport family, score 1.1e-53 716540003982 HMMPfam hit to PF01032, FecCD transport family, score 2.3e-47 716540003983 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 716540003984 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 716540003985 inhibitor-cofactor binding pocket; inhibition site 716540003986 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716540003987 catalytic residue [active] 716540003988 HMMPfam hit to PF00202, Aminotransferase class-III, score 2.2e-86 716540003989 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 716540003990 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 716540003991 HMMPfam hit to PF01521, Iron-sulphur cluster biosynthesis, score 7e-41 716540003992 PS01152 Hypothetical hesB/yadR/yfhF family signature. 716540003993 1 transmembrane helix predicted for EAM_0811 by TMHMM2.0 at aa 10-32 716540003994 Signal peptide predicted for EAM_0811 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 18 and 19 716540003995 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 716540003996 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 716540003997 HMMPfam hit to PF01048, Phosphorylase family, score 7.8e-96 716540003998 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 716540003999 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 716540004000 Zn2+ binding site [ion binding]; other site 716540004001 Mg2+ binding site [ion binding]; other site 716540004002 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 716540004003 HMMPfam hit to PF01966, HD domain, score 6.6e-06 716540004004 serine endoprotease; Provisional; Region: PRK10942 716540004005 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 716540004006 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 716540004007 protein binding site [polypeptide binding]; other site 716540004008 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 716540004009 Signal peptide predicted for EAM_0814 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.975 between residues 26 and 27 716540004010 HMMPfam hit to PF00089, Trypsin, score 1.4e-25 716540004011 HMMPfam hit to PF00595, PDZ domain (Also known as DHR or GLGF), score 7.7e-16 716540004012 HMMPfam hit to PF00595, PDZ domain (Also known as DHR or GLGF), score 1.3e-08 716540004013 hypothetical protein; Provisional; Region: PRK13677 716540004014 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 716540004015 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 716540004016 trimer interface [polypeptide binding]; other site 716540004017 active site 716540004018 substrate binding site [chemical binding]; other site 716540004019 CoA binding site [chemical binding]; other site 716540004020 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.37 716540004021 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 3.1 716540004022 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.74 716540004023 PS00101 Hexapeptide-repeat containing-transferases signature. 716540004024 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 22 716540004025 PII uridylyl-transferase; Provisional; Region: PRK05007 716540004026 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 716540004027 metal binding triad; other site 716540004028 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 716540004029 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 716540004030 Zn2+ binding site [ion binding]; other site 716540004031 Mg2+ binding site [ion binding]; other site 716540004032 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 716540004033 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 716540004034 HMMPfam hit to PF01842, ACT domain, score 6.9e-09 716540004035 HMMPfam hit to PF01842, ACT domain, score 2.2e-07 716540004036 HMMPfam hit to PF01966, HD domain, score 2.8e-22 716540004037 HMMPfam hit to PF08335, GlnD PII-uridylyltransferase, score 1.6e-111 716540004038 HMMPfam hit to PF01909, Nucleotidyltransferase domain, score 2.6e-10 716540004039 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 716540004040 active site 716540004041 HMMPfam hit to PF00557, metallopeptidase family M24, score 1.5e-104 716540004042 PS00680 Methionine aminopeptidase subfamily 1 signature. 716540004043 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 716540004044 rRNA interaction site [nucleotide binding]; other site 716540004045 S8 interaction site; other site 716540004046 putative laminin-1 binding site; other site 716540004047 PS00962 Ribosomal protein S2 signature 1. 716540004048 HMMPfam hit to PF00318, Ribosomal protein S2, score 6.2e-126 716540004049 PS00963 Ribosomal protein S2 signature 2. 716540004050 elongation factor Ts; Provisional; Region: tsf; PRK09377 716540004051 UBA/TS-N domain; Region: UBA; pfam00627 716540004052 Elongation factor TS; Region: EF_TS; pfam00889 716540004053 Elongation factor TS; Region: EF_TS; pfam00889 716540004054 HMMPfam hit to PF00627, UBA/TS-N domain, score 6.1e-13 716540004055 PS01126 Elongation factor Ts signature 1. 716540004056 HMMPfam hit to PF00889, Elongation factor TS, score 3.3e-107 716540004057 PS01127 Elongation factor Ts signature 2. 716540004058 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 716540004059 putative nucleotide binding site [chemical binding]; other site 716540004060 uridine monophosphate binding site [chemical binding]; other site 716540004061 homohexameric interface [polypeptide binding]; other site 716540004062 HMMPfam hit to PF00696, Amino acid kinase family, score 2.5e-62 716540004063 ribosome recycling factor; Reviewed; Region: frr; PRK00083 716540004064 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 716540004065 hinge region; other site 716540004066 HMMPfam hit to PF01765, Ribosome recycling factor, score 1.9e-101 716540004067 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 716540004068 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 716540004069 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 716540004070 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 716540004071 Signal peptide predicted for EAM_0823 by SignalP 2.0 HMM (Signal peptide probability 0.929) with cleavage site probability 0.408 between residues 19 and 20 716540004072 HMMPfam hit to PF02670, 1-deoxy-D-xylulose 5-phosphate reduct, score 4.1e-73 716540004073 HMMPfam hit to PF08436, 1-deoxy-D-xylulose 5-phosphate reduct, score 6.7e-62 716540004074 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 716540004075 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 716540004076 catalytic residue [active] 716540004077 putative FPP diphosphate binding site; other site 716540004078 putative FPP binding hydrophobic cleft; other site 716540004079 dimer interface [polypeptide binding]; other site 716540004080 putative IPP diphosphate binding site; other site 716540004081 HMMPfam hit to PF01255, undecaprenyl diphosphate syntha, score 1.2e-134 716540004082 PS01066 Undecaprenyl pyrophosphate synthetase family signature. 716540004083 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 716540004084 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 716540004085 Signal peptide predicted for EAM_0825 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.914 between residues 29 and 30 716540004086 HMMPfam hit to PF01148, Cytidylyltransferase family, score 8.8e-91 716540004087 8 transmembrane helices predicted for EAM_0825 by TMHMM2.0 at aa 7-24, 28-50, 57-76, 91-113, 120-139, 149-171, 192-211 and 215-234 716540004088 PS01315 Phosphatidate cytidylyltransferase signature. 716540004089 zinc metallopeptidase RseP; Provisional; Region: PRK10779 716540004090 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 716540004091 active site 716540004092 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 716540004093 protein binding site [polypeptide binding]; other site 716540004094 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 716540004095 protein binding site [polypeptide binding]; other site 716540004096 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 716540004097 putative substrate binding region [chemical binding]; other site 716540004098 4 transmembrane helices predicted for EAM_0826 by TMHMM2.0 at aa 2-21, 98-120, 375-397 and 425-444 716540004099 HMMPfam hit to PF02163, Peptidase family M50, score 2.5e-96 716540004100 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 716540004101 HMMPfam hit to PF00595, PDZ domain (Also known as DHR or GLGF), score 2.8e-07 716540004102 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 716540004103 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 716540004104 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 716540004105 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 716540004106 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 716540004107 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 716540004108 Surface antigen; Region: Bac_surface_Ag; pfam01103 716540004109 Signal peptide predicted for EAM_0827 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.962 between residues 20 and 21 716540004110 HMMPfam hit to PF07244, Surface antigen variable number repeat, score 4.9e-11 716540004111 HMMPfam hit to PF07244, Surface antigen variable number repeat, score 6.7e-16 716540004112 HMMPfam hit to PF07244, Surface antigen variable number repeat, score 1.6e-18 716540004113 HMMPfam hit to PF07244, Surface antigen variable number repeat, score 1.3e-16 716540004114 HMMPfam hit to PF07244, Surface antigen variable number repeat, score 1.9e-21 716540004115 HMMPfam hit to PF01103, Surface antigen, score 2e-82 716540004116 periplasmic chaperone; Provisional; Region: PRK10780 716540004117 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 716540004118 Signal peptide predicted for EAM_0828 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.984 between residues 22 and 23 716540004119 HMMPfam hit to PF03938, Outer membrane protein (OmpH-like), score 3.4e-54 716540004120 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 716540004121 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 716540004122 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 716540004123 trimer interface [polypeptide binding]; other site 716540004124 active site 716540004125 UDP-GlcNAc binding site [chemical binding]; other site 716540004126 lipid binding site [chemical binding]; lipid-binding site 716540004127 HMMPfam hit to PF04613, UDP-3-O-[3-hydroxymyristoyl] glucosamine N-a, score 3.2e-49 716540004128 PS00101 Hexapeptide-repeat containing-transferases signature. 716540004129 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.16 716540004130 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.0012 716540004131 PS00101 Hexapeptide-repeat containing-transferases signature. 716540004132 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 1.3 716540004133 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.1 716540004134 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.25 716540004135 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.033 716540004136 PS00101 Hexapeptide-repeat containing-transferases signature. 716540004137 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 1 716540004138 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 16 716540004139 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 716540004140 HMMPfam hit to PF07977, FabA-like domain, score 4.5e-69 716540004141 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 716540004142 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 716540004143 active site 716540004144 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.00031 716540004145 PS00101 Hexapeptide-repeat containing-transferases signature. 716540004146 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 1 716540004147 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.44 716540004148 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 7.4 716540004149 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 31 716540004150 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.27 716540004151 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 26 716540004152 PS00101 Hexapeptide-repeat containing-transferases signature. 716540004153 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 10 716540004154 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 716540004155 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 716540004156 HMMPfam hit to PF02684, Lipid-A-disaccharide synthetase, score 6.9e-191 716540004157 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 716540004158 RNA/DNA hybrid binding site [nucleotide binding]; other site 716540004159 active site 716540004160 HMMPfam hit to PF01351, Ribonuclease HII, score 2.1e-89 716540004161 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 716540004162 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 716540004163 putative active site [active] 716540004164 putative PHP Thumb interface [polypeptide binding]; other site 716540004165 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 716540004166 generic binding surface II; other site 716540004167 generic binding surface I; other site 716540004168 HMMPfam hit to PF02811, PHP domain, score 3.9e-50 716540004169 HMMPfam hit to PF07733, Bacterial DNA polymerase III alpha sub, score 6.5e-303 716540004170 HMMPfam hit to PF01336, OB-fold nucleic acid binding domain, score 2.6e-13 716540004171 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 716540004172 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 716540004173 HMMPfam hit to PF03255, Acetyl co-enzyme A carboxylase carboxyltrans, score 4.9e-98 716540004174 lysine decarboxylase LdcC; Provisional; Region: PRK15399 716540004175 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 716540004176 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 716540004177 homodimer interface [polypeptide binding]; other site 716540004178 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716540004179 catalytic residue [active] 716540004180 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 716540004181 HMMPfam hit to PF03709, Orn/Lys/Arg decarboxylase, N-terminal doma, score 3.6e-34 716540004182 HMMPfam hit to PF01276, Orn/Lys/Arg decarboxylase, major domain, score 1.9e-264 716540004183 PS00703 Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site. 716540004184 HMMPfam hit to PF03711, Orn/Lys/Arg decarboxylase, C-terminal doma, score 3.9e-77 716540004185 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 716540004186 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 716540004187 putative metal binding site [ion binding]; other site 716540004188 HMMPfam hit to PF00903, Glyoxalase/Bleomycin resistance protein/Di, score 1.7e-31 716540004189 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 716540004190 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 716540004191 Ligand Binding Site [chemical binding]; other site 716540004192 TilS substrate binding domain; Region: TilS; pfam09179 716540004193 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 716540004194 HMMPfam hit to PF01171, PP-loop family, score 5.8e-86 716540004195 Signal peptide predicted for EAM_0839 by SignalP 2.0 HMM (Signal peptide probability 0.731) with cleavage site probability 0.673 between residues 19 and 20 716540004196 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210 716540004197 HMMPfam hit to PF07073, Modulator of Rho-dependent transcription ter, score 1.7e-31 716540004198 YaeQ protein; Region: YaeQ; pfam07152 716540004199 HMMPfam hit to PF07152, YaeQ protein, score 3e-110 716540004200 hypothetical protein; Provisional; Region: PRK09256 716540004201 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 716540004202 HMMPfam hit to PF00472, Peptidyl-tRNA hydrolase domain, score 1e-24 716540004203 PS00745 Prokaryotic-type class I peptide chain release factors signature. 716540004204 9 transmembrane helices predicted for EAM_0843 by TMHMM2.0 at aa 7-26, 41-63, 95-117, 127-149, 156-178, 233-250, 255-274, 279-296 and 309-331 716540004205 Signal peptide predicted for EAM_0843 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.978 between residues 20 and 21 716540004206 prolyl-tRNA synthetase; Provisional; Region: PRK09194 716540004207 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 716540004208 dimer interface [polypeptide binding]; other site 716540004209 motif 1; other site 716540004210 active site 716540004211 motif 2; other site 716540004212 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 716540004213 putative deacylase active site [active] 716540004214 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 716540004215 active site 716540004216 motif 3; other site 716540004217 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 716540004218 anticodon binding site; other site 716540004219 HMMPfam hit to PF03129, Anticodon binding domain, score 1.7e-26 716540004220 HMMPfam hit to PF04073, YbaK / prolyl-tRNA synthetases associa, score 4.7e-07 716540004221 HMMPfam hit to PF00587, tRNA synthetase class II core domain (, score 1.3e-61 716540004222 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 716540004223 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 716540004224 homodimer interaction site [polypeptide binding]; other site 716540004225 cofactor binding site; other site 716540004226 HMMPfam hit to PF01980, Uncharacterised protein family UPF0066, score 3.7e-55 716540004227 PS01318 Uncharacterized protein family UPF0066 signature. 716540004228 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 716540004229 Signal peptide predicted for EAM_0846 by SignalP 2.0 HMM (Signal peptide probability 0.969) with cleavage site probability 0.658 between residues 20 and 21 716540004230 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540004231 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 716540004232 lipoprotein, YaeC family; Region: TIGR00363 716540004233 HMMPfam hit to PF03180, NLPA lipoprotein, score 9e-145 716540004234 HMMPfam hit to PF04069, Substrate binding domain of ABC-type gl, score 0.0027 716540004235 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540004236 Signal peptide predicted for EAM_0847 by SignalP 2.0 HMM (Signal peptide probability 0.967) with cleavage site probability 0.881 between residues 22 and 23 716540004237 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540004238 dimer interface [polypeptide binding]; other site 716540004239 conserved gate region; other site 716540004240 ABC-ATPase subunit interface; other site 716540004241 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 4.8e-20 716540004242 5 transmembrane helices predicted for EAM_0848 by TMHMM2.0 at aa 20-42, 55-77, 82-104, 144-166 and 181-203 716540004243 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 716540004244 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 716540004245 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 716540004246 Walker A/P-loop; other site 716540004247 ATP binding site [chemical binding]; other site 716540004248 Q-loop/lid; other site 716540004249 ABC transporter signature motif; other site 716540004250 Walker B; other site 716540004251 D-loop; other site 716540004252 H-loop/switch region; other site 716540004253 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 716540004254 HMMPfam hit to PF00005, ABC transporter, score 9.5e-76 716540004255 PS00211 ABC transporters family signature. 716540004256 PS00017 ATP/GTP-binding site motif A (P-loop). 716540004257 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 716540004258 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716540004259 active site 716540004260 motif I; other site 716540004261 motif II; other site 716540004262 hypothetical protein; Provisional; Region: PRK05421 716540004263 putative catalytic site [active] 716540004264 putative phosphate binding site [ion binding]; other site 716540004265 putative metal binding site [ion binding]; other site 716540004266 HMMPfam hit to PF03372, Endonuclease/Exonuclease/phosphatase fa, score 4.2e-20 716540004267 HMMPfam hit to PF08242, Methyltransferase domain, score 3.1e-06 716540004268 HMMPfam hit to PF08241, Methyltransferase domain, score 2.6e-11 716540004269 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 716540004270 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 716540004271 N-acetyl-D-glucosamine binding site [chemical binding]; other site 716540004272 catalytic residue [active] 716540004273 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 716540004274 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 716540004275 HMMPfam hit to PF01476, LysM domain, score 1.4e-12 716540004276 HMMPfam hit to PF01476, LysM domain, score 1e-13 716540004277 HMMPfam hit to PF01464, Transglycosylase SLT domain, score 4.7e-32 716540004278 PS00922 Prokaryotic transglycosylases signature. 716540004279 HMMPfam hit to PF06474, MLTD_N, score 8.6e-30 716540004280 Signal peptide predicted for EAM_0853 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.971 between residues 20 and 21 716540004281 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540004282 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 716540004283 HMMPfam hit to PF00753, Metallo-beta-lactamase superfamily, score 2.6e-34 716540004284 Methyltransferase domain; Region: Methyltransf_11; pfam08241 716540004285 HMMPfam hit to PF08241, Methyltransferase domain, score 0.00015 716540004286 1 transmembrane helix predicted for EAM_0855 by TMHMM2.0 at aa 121-143 716540004287 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 716540004288 RNA/DNA hybrid binding site [nucleotide binding]; other site 716540004289 active site 716540004290 HMMPfam hit to PF00075, RNase H, score 9.7e-63 716540004291 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 716540004292 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 716540004293 active site 716540004294 catalytic site [active] 716540004295 substrate binding site [chemical binding]; other site 716540004296 HMMPfam hit to PF00929, Exonuclease, score 1.9e-45 716540004297 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 716540004298 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 716540004299 Na binding site [ion binding]; other site 716540004300 putative substrate binding site [chemical binding]; other site 716540004301 12 transmembrane helices predicted for EAM_0858 by TMHMM2.0 at aa 41-63, 67-89, 108-130, 158-180, 193-211, 233-255, 275-297, 317-339, 352-374, 378-400, 434-456 and 460-477 716540004302 HMMPfam hit to PF02133, Permease for cytosine/purines, uracil,, score 4.9e-68 716540004303 Transcriptional regulators [Transcription]; Region: GntR; COG1802 716540004304 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 716540004305 DNA-binding site [nucleotide binding]; DNA binding site 716540004306 FCD domain; Region: FCD; pfam07729 716540004307 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR family, score 2.9e-15 716540004308 Predicted helix-turn-helix motif with score 1185.000, SD 3.22 at aa 39-60, sequence LPEEALSEVFGVSRTGIRKVLQ 716540004309 HMMPfam hit to PF07729, FCD domain, score 1.3e-05 716540004310 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 716540004311 Signal peptide predicted for EAM_0860 by SignalP 2.0 HMM (Signal peptide probability 0.641) with cleavage site probability 0.614 between residues 30 and 31 716540004312 HMMPfam hit to PF01177, Asp/Glu/Hydantoin racemase, score 3.2e-11 716540004313 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 716540004314 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 716540004315 active site 716540004316 catalytic site [active] 716540004317 tetramer interface [polypeptide binding]; other site 716540004318 HMMPfam hit to PF01522, Polysaccharide deacetylase, score 4.1e-11 716540004319 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 716540004320 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 716540004321 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 716540004322 HMMPfam hit to PF04851, Type III restriction enzyme, res subunit, score 1.6e-12 716540004323 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 716540004324 DNA methylase; Region: N6_N4_Mtase; pfam01555 716540004325 DNA methylase; Region: N6_N4_Mtase; pfam01555 716540004326 HMMPfam hit to PF01555, DNA methylase, score 2e-53 716540004327 PS00092 N-6 Adenine-specific DNA methylases signature. 716540004328 Uncharacterized conserved protein [Function unknown]; Region: COG4127 716540004329 Restriction endonuclease; Region: Mrr_cat; pfam04471 716540004330 HMMPfam hit to PF04471, Restriction endonuclease, score 7.4e-11 716540004331 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 716540004332 amidase; Provisional; Region: PRK09201 716540004333 Amidase; Region: Amidase; cl11426 716540004334 HMMPfam hit to PF01425, Amidase, score 1e-107 716540004335 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 716540004336 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 716540004337 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 716540004338 HMMPfam hit to PF01019, Gamma-glutamyltranspeptidase, score 4e-168 716540004339 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 716540004340 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 716540004341 HMMPfam hit to PF01418, Helix-turn-helix domain, rpiR family, score 3e-05 716540004342 Predicted helix-turn-helix motif with score 2101.000, SD 6.34 at aa 36-57, sequence YNSAELARLSGVSKATVSRLFK 716540004343 HMMPfam hit to PF01380, SIS domain, score 0.00058 716540004344 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 716540004345 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 716540004346 substrate binding pocket [chemical binding]; other site 716540004347 membrane-bound complex binding site; other site 716540004348 hinge residues; other site 716540004349 Signal peptide predicted for EAM_0872 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.967 between residues 23 and 24 716540004350 HMMPfam hit to PF00497, Bacterial extracellular solute-binding prot, score 4.1e-44 716540004351 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 716540004352 PS00017 ATP/GTP-binding site motif A (P-loop). 716540004353 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540004354 dimer interface [polypeptide binding]; other site 716540004355 conserved gate region; other site 716540004356 putative PBP binding loops; other site 716540004357 ABC-ATPase subunit interface; other site 716540004358 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 3e-21 716540004359 5 transmembrane helices predicted for EAM_0873 by TMHMM2.0 at aa 22-44, 56-78, 88-105, 147-169 and 179-201 716540004360 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 716540004361 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 716540004362 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540004363 dimer interface [polypeptide binding]; other site 716540004364 conserved gate region; other site 716540004365 putative PBP binding loops; other site 716540004366 ABC-ATPase subunit interface; other site 716540004367 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 4.2e-10 716540004368 5 transmembrane helices predicted for EAM_0874 by TMHMM2.0 at aa 20-39, 59-81, 86-108, 142-164 and 179-201 716540004369 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 716540004370 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 716540004371 Walker A/P-loop; other site 716540004372 ATP binding site [chemical binding]; other site 716540004373 Q-loop/lid; other site 716540004374 ABC transporter signature motif; other site 716540004375 Walker B; other site 716540004376 D-loop; other site 716540004377 H-loop/switch region; other site 716540004378 HMMPfam hit to PF00005, ABC transporter, score 9.9e-68 716540004379 PS00017 ATP/GTP-binding site motif A (P-loop). 716540004380 PS00211 ABC transporters family signature. 716540004381 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 716540004382 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 716540004383 catalytic residue [active] 716540004384 HMMPfam hit to PF00266, Aminotransferase class-V, score 1.7e-11 716540004385 allantoate amidohydrolase; Reviewed; Region: PRK09290 716540004386 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 716540004387 active site 716540004388 metal binding site [ion binding]; metal-binding site 716540004389 dimer interface [polypeptide binding]; other site 716540004390 Signal peptide predicted for EAM_0877 by SignalP 2.0 HMM (Signal peptide probability 0.753) with cleavage site probability 0.442 between residues 20 and 21 716540004391 PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 716540004392 HMMPfam hit to PF01546, Peptidase family M20/M25/M40, score 1e-39 716540004393 HMMPfam hit to PF07687, Peptidase dimerisation domain, score 0.0023 716540004394 OHCU decarboxylase; Region: UraD_2; TIGR03180 716540004395 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 716540004396 active site 716540004397 homotetramer interface [polypeptide binding]; other site 716540004398 HMMPfam hit to PF00576, Transthyretin precursor (formerly preal, score 4.7e-41 716540004399 PS00768 Transthyretin signature 1. 716540004400 xanthine permease; Region: pbuX; TIGR03173 716540004401 HMMPfam hit to PF00860, Permease family, score 1e-90 716540004402 12 transmembrane helices predicted for EAM_0880 by TMHMM2.0 at aa 21-43, 48-70, 77-99, 103-125, 132-154, 169-186, 193-215, 235-252, 316-338, 343-365, 374-396 and 406-425 716540004403 HMMPfam hit to PF00916, Sulfate transporter family, score 0.004 716540004404 PS01116 Xanthine/uracil permeases family signature. 716540004405 C-N hydrolase family amidase; Provisional; Region: PRK10438 716540004406 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 716540004407 active site 716540004408 catalytic triad [active] 716540004409 dimer interface [polypeptide binding]; other site 716540004410 HMMPfam hit to PF00795, Carbon-nitrogen hydrolase, score 8.8e-10 716540004411 methionine aminotransferase; Validated; Region: PRK09082 716540004412 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 716540004413 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716540004414 homodimer interface [polypeptide binding]; other site 716540004415 catalytic residue [active] 716540004416 HMMPfam hit to PF00155, Aminotransferase class I and II, score 3.8e-51 716540004417 PS00017 ATP/GTP-binding site motif A (P-loop). 716540004418 Signal peptide predicted for EAM_0882 by SignalP 2.0 HMM (Signal peptide probability 0.835) with cleavage site probability 0.766 between residues 27 and 28 716540004419 Toxin YafO, type II toxin-antitoxin system; Region: YafO_toxin; cl08066 716540004420 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 716540004421 intersubunit interface [polypeptide binding]; other site 716540004422 active site 716540004423 Zn2+ binding site [ion binding]; other site 716540004424 HMMPfam hit to PF00596, Class II Aldolase and Adducin N-terminal, score 2.2e-33 716540004425 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691 716540004426 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 716540004427 motif II; other site 716540004428 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 2.9e-11 716540004429 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 716540004430 Cupin domain; Region: Cupin_2; cl17218 716540004431 HMMPfam hit to PF03079, ARD/ARD' family, score 7.7e-43 716540004432 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 716540004433 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 716540004434 HMMPfam hit to PF01008, Initiation factor 2 subunit family, score 4.5e-84 716540004435 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 716540004436 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 716540004437 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 716540004438 active site 716540004439 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 716540004440 HMMPfam hit to PF00441, Acyl-CoA dehydrogenase, C-terminal doma, score 1.5e-07 716540004441 HMMPfam hit to PF02771, Acyl-CoA dehydrogenase, N-terminal doma, score 9.8e-06 716540004442 2 transmembrane helices predicted for EAM_0890 by TMHMM2.0 at aa 4-21 and 28-50 716540004443 Signal peptide predicted for EAM_0890 by SignalP 2.0 HMM (Signal peptide probability 0.938) with cleavage site probability 0.802 between residues 25 and 26 716540004444 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 716540004445 dimer interface [polypeptide binding]; other site 716540004446 active site 716540004447 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 716540004448 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 716540004449 putative active site [active] 716540004450 putative dimer interface [polypeptide binding]; other site 716540004451 HMMPfam hit to PF00310, Glutamine amidotransferases class-II, score 1.7e-28 716540004452 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 716540004453 HMMPfam hit to PF06104, Bacterial protein of unknown function (DUF94, score 1.8e-126 716540004454 Signal peptide predicted for EAM_0893 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.962 between residues 19 and 20 716540004455 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 716540004456 active site 716540004457 DNA polymerase IV; Validated; Region: PRK02406 716540004458 DNA binding site [nucleotide binding] 716540004459 HMMPfam hit to PF00817, impB/mucB/samB family, score 7e-126 716540004460 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 716540004461 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 716540004462 metal binding site [ion binding]; metal-binding site 716540004463 dimer interface [polypeptide binding]; other site 716540004464 HMMPfam hit to PF01546, Peptidase family M20/M25/M40, score 1e-08 716540004465 HMMPfam hit to PF07687, Peptidase dimerisation domain, score 8.3e-09 716540004466 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 716540004467 active site 716540004468 HMMPfam hit to PF00156, Phosphoribosyl transferase domain, score 8.1e-17 716540004469 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 716540004470 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 716540004471 HMMPfam hit to PF06500, Alpha/beta hydrolase of unknown function (DU, score 2.6e-223 716540004472 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 716540004473 HMMPfam hit to PF07417, Transcriptional regulator Crl, score 8e-72 716540004474 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 716540004475 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 716540004476 eyelet of channel; other site 716540004477 trimer interface [polypeptide binding]; other site 716540004478 HMMPfam hit to PF00267, Gram-negative porin, score 2.5e-154 716540004479 1 transmembrane helix predicted for EAM_0901 by TMHMM2.0 at aa 7-26 716540004480 Signal peptide predicted for EAM_0901 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 22 and 23 716540004481 gamma-glutamyl kinase; Provisional; Region: PRK05429 716540004482 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 716540004483 nucleotide binding site [chemical binding]; other site 716540004484 homotetrameric interface [polypeptide binding]; other site 716540004485 putative phosphate binding site [ion binding]; other site 716540004486 putative allosteric binding site; other site 716540004487 PUA domain; Region: PUA; pfam01472 716540004488 HMMPfam hit to PF00696, Amino acid kinase family, score 1.7e-56 716540004489 PS00902 Glutamate 5-kinase signature. 716540004490 HMMPfam hit to PF01472, PUA domain, score 2.6e-27 716540004491 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 716540004492 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 716540004493 putative catalytic cysteine [active] 716540004494 HMMPfam hit to PF00171, Aldehyde dehydrogenase family, score 5.5e-07 716540004495 PS01223 Gamma-glutamyl phosphate reductase signature. 716540004496 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 716540004497 HMMPfam hit to PF04304, Protein of unknown function (DUF454), score 1.1e-12 716540004498 3 transmembrane helices predicted for EAM_0904 by TMHMM2.0 at aa 21-43, 94-111 and 116-133 716540004499 chromosome condensation membrane protein; Provisional; Region: PRK14196 716540004500 HMMPfam hit to PF02537, CrcB-like protein, score 1.7e-32 716540004501 4 transmembrane helices predicted for EAM_0905 by TMHMM2.0 at aa 5-23, 36-58, 68-90 and 97-119 716540004502 2 transmembrane helices predicted for EAM_0906 by TMHMM2.0 at aa 36-58 and 89-111 716540004503 anti-RssB factor; Provisional; Region: PRK10244 716540004504 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540004505 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716540004506 S-adenosylmethionine binding site [chemical binding]; other site 716540004507 HMMPfam hit to PF08241, Methyltransferase domain, score 0.0022 716540004508 HMMPfam hit to PF08242, Methyltransferase domain, score 6.4e-05 716540004509 Acyltransferase family; Region: Acyl_transf_3; pfam01757 716540004510 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 716540004511 10 transmembrane helices predicted for EAM_0912 by TMHMM2.0 at aa 7-29, 33-52, 64-86, 106-128, 135-152, 167-186, 198-220, 230-252, 264-286 and 296-318 716540004512 Signal peptide predicted for EAM_0913 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.551 between residues 32 and 33 716540004513 KTSC domain; Region: KTSC; pfam13619 716540004514 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 716540004515 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 716540004516 Walker A/P-loop; other site 716540004517 ATP binding site [chemical binding]; other site 716540004518 Q-loop/lid; other site 716540004519 ABC transporter signature motif; other site 716540004520 Walker B; other site 716540004521 D-loop; other site 716540004522 H-loop/switch region; other site 716540004523 HMMPfam hit to PF00005, ABC transporter, score 3.7e-55 716540004524 PS00211 ABC transporters family signature. 716540004525 PS00017 ATP/GTP-binding site motif A (P-loop). 716540004526 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 716540004527 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 716540004528 Walker A/P-loop; other site 716540004529 ATP binding site [chemical binding]; other site 716540004530 Q-loop/lid; other site 716540004531 ABC transporter signature motif; other site 716540004532 Walker B; other site 716540004533 D-loop; other site 716540004534 H-loop/switch region; other site 716540004535 HMMPfam hit to PF00005, ABC transporter, score 3.8e-46 716540004536 PS00017 ATP/GTP-binding site motif A (P-loop). 716540004537 Signal peptide predicted for EAM_0917 by SignalP 2.0 HMM (Signal peptide probability 0.706) with cleavage site probability 0.699 between residues 21 and 22 716540004538 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 716540004539 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540004540 dimer interface [polypeptide binding]; other site 716540004541 conserved gate region; other site 716540004542 ABC-ATPase subunit interface; other site 716540004543 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 2e-41 716540004544 5 transmembrane helices predicted for EAM_0918 by TMHMM2.0 at aa 20-42, 86-108, 131-153, 206-228 and 248-270 716540004545 Signal peptide predicted for EAM_0918 by SignalP 2.0 HMM (Signal peptide probability 0.712) with cleavage site probability 0.534 between residues 42 and 43 716540004546 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 716540004547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540004548 dimer interface [polypeptide binding]; other site 716540004549 conserved gate region; other site 716540004550 putative PBP binding loops; other site 716540004551 ABC-ATPase subunit interface; other site 716540004552 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.4e-43 716540004553 6 transmembrane helices predicted for EAM_0919 by TMHMM2.0 at aa 21-43, 116-138, 151-173, 217-239, 265-287 and 320-342 716540004554 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 716540004555 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 716540004556 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 2.7e-59 716540004557 Signal peptide predicted for EAM_0920 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.842 between residues 21 and 22 716540004558 CAAX protease self-immunity; Region: Abi; pfam02517 716540004559 HMMPfam hit to PF02517, CAAX amino terminal protease family, score 7.4e-16 716540004560 6 transmembrane helices predicted for EAM_0921 by TMHMM2.0 at aa 12-31, 41-59, 79-96, 116-138, 150-167 and 172-191 716540004561 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 716540004562 Signal peptide predicted for EAM_0922 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.548 between residues 22 and 23 716540004563 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540004564 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 716540004565 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 716540004566 DNA-binding site [nucleotide binding]; DNA binding site 716540004567 RNA-binding motif; other site 716540004568 HMMPfam hit to PF00313, 'Cold-shock' DNA-binding domain, score 1.7e-42 716540004569 PS00352 'Cold-shock' DNA-binding domain signature. 716540004570 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 716540004571 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 716540004572 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 716540004573 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 716540004574 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 716540004575 HMMPfam hit to PF02929, Beta galactosidase small chain, score 8.7e-106 716540004576 HMMPfam hit to PF02836, Glycosyl hydrolases family 2, TIM bar, score 6.4e-173 716540004577 PS00608 Glycosyl hydrolases family 2 acid/base catalyst. 716540004578 PS00719 Glycosyl hydrolases family 2 signature 1. 716540004579 HMMPfam hit to PF00703, Glycosyl hydrolases family 2, immunog, score 5.1e-29 716540004580 HMMPfam hit to PF02837, Glycosyl hydrolases family 2, sugar b, score 4e-82 716540004581 psiF repeat; Region: PsiF_repeat; pfam07769 716540004582 psiF repeat; Region: PsiF_repeat; pfam07769 716540004583 Signal peptide predicted for EAM_0927 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 22 and 23 716540004584 1 transmembrane helix predicted for EAM_0927 by TMHMM2.0 at aa 5-23 716540004585 HMMPfam hit to PF07769, psiF repeat, score 3e-16 716540004586 HMMPfam hit to PF07769, psiF repeat, score 6e-21 716540004587 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 716540004588 2 transmembrane helices predicted for EAM_0928 by TMHMM2.0 at aa 4-22 and 280-302 716540004589 HMMPfam hit to PF05118, Aspartyl/Asparaginyl beta-hydroxylase, score 3.6e-87 716540004590 Predicted helix-turn-helix motif with score 1009.000, SD 2.62 at aa 264-285, sequence NRIRDVGQNLKKRNRTLYYWVK 716540004591 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 716540004592 pyrroline-5-carboxylate reductase; Region: PLN02688 716540004593 HMMPfam hit to PF03807, NADP oxidoreductase coenzyme F420-depe, score 8.9e-82 716540004594 PS00521 Delta 1-pyrroline-5-carboxylate reductase signature. 716540004595 HMMPfam hit to PF01210, NAD-dependent glycerol-3-phosphate deh, score 0.003 716540004596 hypothetical protein; Validated; Region: PRK00124 716540004597 HMMPfam hit to PF02639, Uncharacterized BCR, YaiI/YqxD family COG167, score 1.3e-75 716540004598 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 716540004599 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 716540004600 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 716540004601 ADP binding site [chemical binding]; other site 716540004602 magnesium binding site [ion binding]; other site 716540004603 putative shikimate binding site; other site 716540004604 PS00017 ATP/GTP-binding site motif A (P-loop). 716540004605 HMMPfam hit to PF01202, Shikimate kinase, score 3.2e-61 716540004606 PS01128 Shikimate kinase signature. 716540004607 hypothetical protein; Provisional; Region: PRK10380 716540004608 Transcriptional regulator [Transcription]; Region: IclR; COG1414 716540004609 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 716540004610 putative DNA binding site [nucleotide binding]; other site 716540004611 putative Zn2+ binding site [ion binding]; other site 716540004612 Bacterial transcriptional regulator; Region: IclR; pfam01614 716540004613 HMMPfam hit to PF01022, Bacterial regulatory protein, arsR family, score 0.0049 716540004614 Predicted helix-turn-helix motif with score 1760.000, SD 5.18 at aa 26-47, sequence LTFSAVVEALGLPKSTVSRLLS 716540004615 HMMPfam hit to PF01614, Bacterial transcriptional regulator, score 1.1e-06 716540004616 OPT oligopeptide transporter protein; Region: OPT; cl14607 716540004617 HMMPfam hit to PF03169, OPT oligopeptide transporter protein, score 5.8e-10 716540004618 14 transmembrane helices predicted for EAM_0935 by TMHMM2.0 at aa 12-31, 35-54, 75-97, 102-124, 152-171, 176-198, 210-232, 256-278, 285-307, 317-339, 381-403, 425-447, 454-476 and 491-513 716540004619 Protein of unknown function (DUF1177); Region: DUF1177; pfam06675 716540004620 HMMPfam hit to PF06675, Protein of unknown function (DUF1177), score 1.7e-144 716540004621 hypothetical protein; Provisional; Region: PRK10481 716540004622 HMMPfam hit to PF07302, AroM protein, score 2.8e-73 716540004623 hypothetical protein; Provisional; Region: PRK10579 716540004624 HMMPfam hit to PF06865, Protein of unknown function (DUF1255), score 7.1e-55 716540004625 recombination associated protein; Reviewed; Region: rdgC; PRK00321 716540004626 HMMPfam hit to PF04381, exonuclease, RdgC, score 6.4e-200 716540004627 ethanolamine permease; Region: 2A0305; TIGR00908 716540004628 HMMPfam hit to PF00324, Amino acid permease, score 1.8e-07 716540004629 12 transmembrane helices predicted for EAM_0940 by TMHMM2.0 at aa 12-34, 38-60, 86-108, 123-140, 147-169, 184-206, 227-249, 276-298, 328-347, 357-379, 392-414 and 418-437 716540004630 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 716540004631 active site 716540004632 substrate binding site [chemical binding]; other site 716540004633 Phosphotransferase enzyme family; Region: APH; pfam01636 716540004634 ATP binding site [chemical binding]; other site 716540004635 HMMPfam hit to PF01636, Phosphotransferase enzyme family, score 3.4e-24 716540004636 PS00109 Tyrosine protein kinases specific active-site signature. 716540004637 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 716540004638 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 716540004639 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716540004640 Predicted helix-turn-helix motif with score 1134.000, SD 3.05 at aa 268-289, sequence PLLEEVAEKMGLTSWSLQRRLR 716540004641 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 1.4e-11 716540004642 TolA C-terminal; Region: TolA; pfam06519 716540004643 Signal peptide predicted for EAM_0943 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.539 between residues 24 and 25 716540004644 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540004645 Curli production assembly/transport component CsgG; Region: CsgG; pfam03783 716540004646 Signal peptide predicted for EAM_0944 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.660 between residues 29 and 30 716540004647 HMMPfam hit to PF03783, Curli production assembly/transport componen, score 3.7e-74 716540004648 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540004649 PS00017 ATP/GTP-binding site motif A (P-loop). 716540004650 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 716540004651 Signal peptide predicted for EAM_0945 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.605 between residues 22 and 23 716540004652 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540004653 Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813 716540004654 HMMPfam hit to PF05643, bacterial lipoprotein (DUF799), score 4.1e-67 716540004655 Signal peptide predicted for EAM_0946 by SignalP 2.0 HMM (Signal peptide probability 0.982) with cleavage site probability 0.583 between residues 21 and 22 716540004656 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540004657 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716540004658 Walker A/P-loop; other site 716540004659 ATP binding site [chemical binding]; other site 716540004660 Q-loop/lid; other site 716540004661 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716540004662 ABC transporter signature motif; other site 716540004663 Walker B; other site 716540004664 D-loop; other site 716540004665 H-loop/switch region; other site 716540004666 HMMPfam hit to PF02463, RecF/RecN/SMC N terminal domain, score 5.9e-07 716540004667 PS00017 ATP/GTP-binding site motif A (P-loop). 716540004668 HMMPfam hit to PF00904, no description, score 59 716540004669 HMMPfam hit to PF00904, no description, score 1.9e+02 716540004670 HMMPfam hit to PF00904, no description, score 2e+02 716540004671 HMMPfam hit to PF00904, no description, score 2.7e+02 716540004672 HMMPfam hit to PF00904, no description, score 1.3e+02 716540004673 HMMPfam hit to PF00904, no description, score 3.7e+02 716540004674 HMMPfam hit to PF00904, no description, score 1.7e+02 716540004675 PS00017 ATP/GTP-binding site motif A (P-loop). 716540004676 exonuclease subunit SbcD; Provisional; Region: PRK10966 716540004677 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 716540004678 active site 716540004679 metal binding site [ion binding]; metal-binding site 716540004680 DNA binding site [nucleotide binding] 716540004681 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 716540004682 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 5.8e-14 716540004683 transcriptional regulator PhoB; Provisional; Region: PRK10161 716540004684 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716540004685 active site 716540004686 phosphorylation site [posttranslational modification] 716540004687 intermolecular recognition site; other site 716540004688 dimerization interface [polypeptide binding]; other site 716540004689 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 716540004690 DNA binding site [nucleotide binding] 716540004691 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.6e-37 716540004692 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 1.5e-21 716540004693 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 716540004694 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 716540004695 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 716540004696 putative active site [active] 716540004697 heme pocket [chemical binding]; other site 716540004698 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 716540004699 dimer interface [polypeptide binding]; other site 716540004700 phosphorylation site [posttranslational modification] 716540004701 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716540004702 ATP binding site [chemical binding]; other site 716540004703 Mg2+ binding site [ion binding]; other site 716540004704 G-X-G motif; other site 716540004705 1 transmembrane helix predicted for EAM_0950 by TMHMM2.0 at aa 13-35 716540004706 HMMPfam hit to PF00989, PAS fold, score 2.3e-11 716540004707 HMMPfam hit to PF08448, PAS fold, score 0.0019 716540004708 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 1.6e-24 716540004709 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 2.8e-38 716540004710 PBP superfamily domain; Region: PBP_like_2; cl17296 716540004711 Signal peptide predicted for EAM_0951 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.849 between residues 18 and 19 716540004712 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 716540004713 substrate binding site [chemical binding]; other site 716540004714 THF binding site; other site 716540004715 zinc-binding site [ion binding]; other site 716540004716 HMMPfam hit to PF01717, Cobalamin-independent synthase, Catalytic, score 8.8e-07 716540004717 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 716540004718 Signal peptide predicted for EAM_0953 by SignalP 2.0 HMM (Signal peptide probability 0.961) with cleavage site probability 0.884 between residues 24 and 25 716540004719 HMMPfam hit to PF05525, Branched-chain amino acid transport p, score 1.5e-225 716540004720 12 transmembrane helices predicted for EAM_0953 by TMHMM2.0 at aa 13-35, 41-63, 76-98, 118-140, 147-169, 189-211, 223-245, 275-297, 317-339, 344-363, 370-387 and 409-426 716540004721 putative proline-specific permease; Provisional; Region: proY; PRK10580 716540004722 Signal peptide predicted for EAM_0954 by SignalP 2.0 HMM (Signal peptide probability 0.990) with cleavage site probability 0.303 between residues 33 and 34 716540004723 12 transmembrane helices predicted for EAM_0954 by TMHMM2.0 at aa 13-30, 35-57, 81-103, 123-145, 152-174, 197-219, 240-262, 277-299, 328-350, 355-377, 399-421 and 426-445 716540004724 HMMPfam hit to PF00324, Amino acid permease, score 4.8e-123 716540004725 PS00218 Amino acid permeases signature. 716540004726 peroxidase; Provisional; Region: PRK15000 716540004727 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 716540004728 dimer interface [polypeptide binding]; other site 716540004729 decamer (pentamer of dimers) interface [polypeptide binding]; other site 716540004730 catalytic triad [active] 716540004731 peroxidatic and resolving cysteines [active] 716540004732 HMMPfam hit to PF00578, AhpC/TSA family, score 2e-81 716540004733 HMMPfam hit to PF08534, Redoxin, score 3.3e-10 716540004734 Protein of unknown function, DUF479; Region: DUF479; cl01203 716540004735 HMMPfam hit to PF04336, Protein of unknown function, DUF479, score 1.1e-76 716540004736 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 716540004737 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 716540004738 HMMPfam hit to PF02547, Queuosine biosynthesis protein, score 3.6e-137 716540004739 Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304 716540004740 9 transmembrane helices predicted for EAM_0958 by TMHMM2.0 at aa 19-41, 87-109, 136-158, 173-195, 207-229, 272-294, 301-323, 327-346 and 353-375 716540004741 Signal peptide predicted for EAM_0958 by SignalP 2.0 HMM (Signal peptide probability 0.990) with cleavage site probability 0.495 between residues 44 and 45 716540004742 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 716540004743 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 716540004744 Ligand binding site; other site 716540004745 Putative Catalytic site; other site 716540004746 DXD motif; other site 716540004747 2 transmembrane helices predicted for EAM_0959 by TMHMM2.0 at aa 225-247 and 262-284 716540004748 HMMPfam hit to PF00535, Glycosyl transferase family, score 4.4e-26 716540004749 Predicted membrane protein [Function unknown]; Region: COG2246 716540004750 GtrA-like protein; Region: GtrA; pfam04138 716540004751 4 transmembrane helices predicted for EAM_0960 by TMHMM2.0 at aa 7-29, 33-55, 68-85 and 95-117 716540004752 HMMPfam hit to PF04138, GtrA-like protein, score 9.5e-18 716540004753 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 716540004754 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 716540004755 HMMPfam hit to PF01702, Queuine tRNA-ribosyltransferase, score 4.4e-167 716540004756 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 716540004757 HMMPfam hit to PF02699, Preprotein translocase subunit, score 2.7e-44 716540004758 1 transmembrane helix predicted for EAM_0962 by TMHMM2.0 at aa 20-38 716540004759 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 716540004760 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 716540004761 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 716540004762 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 716540004763 Signal peptide predicted for EAM_0963 by SignalP 2.0 HMM (Signal peptide probability 0.954) with cleavage site probability 0.576 between residues 30 and 31 716540004764 6 transmembrane helices predicted for EAM_0963 by TMHMM2.0 at aa 7-29, 450-472, 475-497, 502-524, 548-570 and 580-602 716540004765 HMMPfam hit to PF07549, SecD/SecF GG Motif, score 1.5e-05 716540004766 PS00761 Signal peptidases I signature 3. 716540004767 HMMPfam hit to PF02355, Protein export membrane protein, score 3.3e-06 716540004768 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 716540004769 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 716540004770 Protein export membrane protein; Region: SecD_SecF; pfam02355 716540004771 6 transmembrane helices predicted for EAM_0964 by TMHMM2.0 at aa 25-47, 142-161, 168-190, 194-211, 247-269 and 274-296 716540004772 HMMPfam hit to PF07549, SecD/SecF GG Motif, score 1.4e-05 716540004773 HMMPfam hit to PF02355, Protein export membrane protein, score 1.6e-85 716540004774 hypothetical protein; Provisional; Region: PRK11530 716540004775 Signal peptide predicted for EAM_0965 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.499 between residues 26 and 27 716540004776 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540004777 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 716540004778 BON domain; Region: BON; pfam04972 716540004779 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 716540004780 HMMPfam hit to PF01476, LysM domain, score 1.7e-13 716540004781 HMMPfam hit to PF04972, phospholipid-binding domain, score 2.9e-09 716540004782 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 716540004783 ATP cone domain; Region: ATP-cone; pfam03477 716540004784 PS00190 Cytochrome c family heme-binding site signature. 716540004785 HMMPfam hit to PF03477, ATP cone domain, score 2.3e-32 716540004786 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 716540004787 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 716540004788 catalytic motif [active] 716540004789 Zn binding site [ion binding]; other site 716540004790 RibD C-terminal domain; Region: RibD_C; cl17279 716540004791 HMMPfam hit to PF00383, Cytidine and deoxycytidylate deaminas, score 1.9e-44 716540004792 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 716540004793 HMMPfam hit to PF01872, RibD C-terminal domain, score 1.3e-71 716540004794 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 716540004795 homopentamer interface [polypeptide binding]; other site 716540004796 active site 716540004797 HMMPfam hit to PF00885, 6,7-dimethyl-8-ribityllumazine synthase, score 3.3e-89 716540004798 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 716540004799 putative RNA binding site [nucleotide binding]; other site 716540004800 HMMPfam hit to PF01029, NusB family, score 9.9e-50 716540004801 thiamine monophosphate kinase; Provisional; Region: PRK05731 716540004802 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 716540004803 ATP binding site [chemical binding]; other site 716540004804 dimerization interface [polypeptide binding]; other site 716540004805 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal dom, score 3.4e-05 716540004806 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 716540004807 tetramer interfaces [polypeptide binding]; other site 716540004808 binuclear metal-binding site [ion binding]; other site 716540004809 Signal peptide predicted for EAM_0972 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.670 between residues 35 and 36 716540004810 HMMPfam hit to PF04608, Phosphatidylglycerophosphatase A, score 6.9e-88 716540004811 4 transmembrane helices predicted for EAM_0972 by TMHMM2.0 at aa 13-35, 50-67, 87-109 and 129-151 716540004812 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 716540004813 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 716540004814 TPP-binding site; other site 716540004815 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 716540004816 PYR/PP interface [polypeptide binding]; other site 716540004817 dimer interface [polypeptide binding]; other site 716540004818 TPP binding site [chemical binding]; other site 716540004819 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 716540004820 HMMPfam hit to PF02780, Transketolase, C-terminal domain, score 9.3e-36 716540004821 HMMPfam hit to PF02779, Transketolase, pyridine binding domai, score 8.9e-60 716540004822 PS00802 Transketolase signature 2. 716540004823 PS00017 ATP/GTP-binding site motif A (P-loop). 716540004824 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 716540004825 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 716540004826 substrate binding pocket [chemical binding]; other site 716540004827 chain length determination region; other site 716540004828 substrate-Mg2+ binding site; other site 716540004829 catalytic residues [active] 716540004830 aspartate-rich region 1; other site 716540004831 active site lid residues [active] 716540004832 aspartate-rich region 2; other site 716540004833 HMMPfam hit to PF00348, Polyprenyl synthetase, score 3.5e-115 716540004834 PS00678 Trp-Asp (WD) repeats signature. 716540004835 PS00017 ATP/GTP-binding site motif A (P-loop). 716540004836 PS00444 Polyprenyl synthetases signature 2. 716540004837 PS00723 Polyprenyl synthetases signature 1. 716540004838 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 716540004839 HMMPfam hit to PF02609, Exonuclease VII small subunit, score 8.4e-30 716540004840 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 716540004841 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 716540004842 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 716540004843 Ligand Binding Site [chemical binding]; other site 716540004844 thiazole biosynthesis domain; Region: ThiI_C_thiazole; TIGR04271 716540004845 active site residue [active] 716540004846 HMMPfam hit to PF02926, THUMP domain, score 4.7e-22 716540004847 HMMPfam hit to PF02568, Thiamine biosynthesis protein (ThiI), score 7.3e-108 716540004848 HMMPfam hit to PF06508, ExsB, score 0.003 716540004849 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 716540004850 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 716540004851 conserved cys residue [active] 716540004852 HMMPfam hit to PF01965, DJ-1/PfpI family, score 1.2e-43 716540004853 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 716540004854 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 716540004855 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 716540004856 HMMPfam hit to PF08546, Ketopantoate reductase PanE/ApbA C terminal, score 3.9e-52 716540004857 HMMPfam hit to PF02558, Ketopantoate reductase PanE/ApbA, score 2.9e-33 716540004858 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 716540004859 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 716540004860 HMMPfam hit to PF04461, Protein of unknown function (DUF520), score 2.4e-108 716540004861 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 716540004862 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540004863 Major Facilitator Superfamily; Region: MFS_1; pfam07690 716540004864 putative substrate translocation pore; other site 716540004865 12 transmembrane helices predicted for EAM_0980 by TMHMM2.0 at aa 13-35, 50-72, 79-101, 105-124, 137-159, 164-186, 217-239, 249-271, 280-302, 306-328, 340-362 and 367-386 716540004866 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 3.7e-49 716540004867 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 716540004868 UbiA prenyltransferase family; Region: UbiA; pfam01040 716540004869 9 transmembrane helices predicted for EAM_0981 by TMHMM2.0 at aa 5-27, 37-59, 79-101, 106-125, 132-154, 159-181, 208-230, 234-251 and 263-285 716540004870 HMMPfam hit to PF01040, UbiA prenyltransferase family, score 2.3e-83 716540004871 PS00943 UbiA prenyltransferase family signature. 716540004872 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 716540004873 HMMPfam hit to PF03626, Prokaryotic Cytochrome C oxidase subunit IV, score 8.9e-50 716540004874 3 transmembrane helices predicted for EAM_0982 by TMHMM2.0 at aa 15-37, 44-66 and 76-98 716540004875 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 716540004876 Subunit I/III interface [polypeptide binding]; other site 716540004877 Subunit III/IV interface [polypeptide binding]; other site 716540004878 HMMPfam hit to PF00510, Cytochrome c oxidase subunit III, score 2.4e-06 716540004879 5 transmembrane helices predicted for EAM_0983 by TMHMM2.0 at aa 29-51, 66-88, 97-118, 138-160 and 181-203 716540004880 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 716540004881 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 716540004882 D-pathway; other site 716540004883 Putative ubiquinol binding site [chemical binding]; other site 716540004884 Low-spin heme (heme b) binding site [chemical binding]; other site 716540004885 Putative water exit pathway; other site 716540004886 Binuclear center (heme o3/CuB) [ion binding]; other site 716540004887 K-pathway; other site 716540004888 Putative proton exit pathway; other site 716540004889 14 transmembrane helices predicted for EAM_0984 by TMHMM2.0 at aa 15-37, 57-79, 102-124, 144-166, 190-212, 233-255, 275-297, 310-332, 347-369, 382-404, 414-436, 457-479, 494-516 and 590-612 716540004890 HMMPfam hit to PF00115, Cytochrome C and Quinol oxidase polypeptide, score 2.1e-257 716540004891 PS00077 Heme-copper oxidase catalytic subunit, copper B binding region signature. 716540004892 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 716540004893 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 716540004894 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 716540004895 HMMPfam hit to PF06481, COX Aromatic Rich Motif, score 7e-14 716540004896 HMMPfam hit to PF00116, Cytochrome C oxidase subunit II, periplasmic, score 1.1e-05 716540004897 3 transmembrane helices predicted for EAM_0985 by TMHMM2.0 at aa 12-30, 45-67 and 88-108 716540004898 Signal peptide predicted for EAM_0985 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.672 between residues 28 and 29 716540004899 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540004900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540004901 putative substrate translocation pore; other site 716540004902 14 transmembrane helices predicted for EAM_0986 by TMHMM2.0 at aa 13-35, 50-69, 82-104, 109-131, 144-166, 171-193, 228-250, 260-282, 287-309, 319-341, 354-376, 380-402, 435-457 and 462-484 716540004903 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.3e-26 716540004904 Signal peptide predicted for EAM_0986 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.403 between residues 37 and 38 716540004905 hypothetical protein; Provisional; Region: PRK11627 716540004906 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 716540004907 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 716540004908 HMMPfam hit to PF03923, Uncharacterized lipoprotein, score 1.8e-10 716540004909 Signal peptide predicted for EAM_0987 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.681 between residues 24 and 25 716540004910 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540004911 transcriptional regulator BolA; Provisional; Region: PRK11628 716540004912 HMMPfam hit to PF01722, BolA-like protein, score 2.7e-32 716540004913 trigger factor; Provisional; Region: tig; PRK01490 716540004914 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 716540004915 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 716540004916 HMMPfam hit to PF05697, Bacterial trigger factor protein (TF), score 4.7e-69 716540004917 HMMPfam hit to PF00254, FKBP-type peptidyl-prolyl cis-trans isomera, score 5.3e-28 716540004918 HMMPfam hit to PF05698, Bacterial trigger factor protein (TF) C-ter, score 3.7e-61 716540004919 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 716540004920 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 716540004921 oligomer interface [polypeptide binding]; other site 716540004922 active site residues [active] 716540004923 HMMPfam hit to PF00574, Clp protease, score 1.4e-137 716540004924 PS00381 Endopeptidase Clp serine active site. 716540004925 PS00382 Endopeptidase Clp histidine active site. 716540004926 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 716540004927 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 716540004928 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716540004929 Walker A motif; other site 716540004930 ATP binding site [chemical binding]; other site 716540004931 Walker B motif; other site 716540004932 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 716540004933 HMMPfam hit to PF06689, ClpX C4-type zinc finger, score 6.9e-26 716540004934 HMMPfam hit to PF07724, ATPase family associated with various cell, score 1.1e-79 716540004935 HMMPfam hit to PF00004, ATPase family associated with various cell, score 1.7e-05 716540004936 PS00017 ATP/GTP-binding site motif A (P-loop). 716540004937 Clp protease; Region: CLP_protease; pfam00574 716540004938 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 716540004939 oligomer interface [polypeptide binding]; other site 716540004940 active site residues [active] 716540004941 HMMPfam hit to PF00574, Clp protease, score 9.2e-84 716540004942 PS00382 Endopeptidase Clp histidine active site. 716540004943 1 transmembrane helix predicted for EAM_0992 by TMHMM2.0 at aa 88-107 716540004944 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 716540004945 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 716540004946 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716540004947 Walker A motif; other site 716540004948 ATP binding site [chemical binding]; other site 716540004949 Walker B motif; other site 716540004950 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 716540004951 HMMPfam hit to PF06689, ClpX C4-type zinc finger, score 4.9e-27 716540004952 HMMPfam hit to PF07724, ATPase family associated with various cell, score 1.1e-79 716540004953 PS00017 ATP/GTP-binding site motif A (P-loop). 716540004954 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 716540004955 Found in ATP-dependent protease La (LON); Region: LON; smart00464 716540004956 Found in ATP-dependent protease La (LON); Region: LON; smart00464 716540004957 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716540004958 Walker A motif; other site 716540004959 ATP binding site [chemical binding]; other site 716540004960 Walker B motif; other site 716540004961 arginine finger; other site 716540004962 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 716540004963 HMMPfam hit to PF02190, ATP-dependent protease La (LON) domain, score 2.5e-78 716540004964 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 3.8e-44 716540004965 HMMPfam hit to PF07728, ATPase family associated with various cellul, score 1.1e-05 716540004966 PS00017 ATP/GTP-binding site motif A (P-loop). 716540004967 HMMPfam hit to PF05362, Lon protease (S16) C-terminal proteolytic do, score 6.3e-157 716540004968 PS01046 ATP-dependent serine proteases, lon family, serine active site. 716540004969 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 716540004970 IHF dimer interface [polypeptide binding]; other site 716540004971 IHF - DNA interface [nucleotide binding]; other site 716540004972 HMMPfam hit to PF00216, Bacterial DNA-binding protein, score 1e-48 716540004973 PS00045 Bacterial histone-like DNA-binding proteins signature. 716540004974 periplasmic folding chaperone; Provisional; Region: PRK10788 716540004975 SurA N-terminal domain; Region: SurA_N_3; cl07813 716540004976 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 716540004977 1 transmembrane helix predicted for EAM_0996 by TMHMM2.0 at aa 12-34 716540004978 HMMPfam hit to PF00639, PPIC-type PPIASE domain, score 2.4e-17 716540004979 PS01096 PpiC-type peptidyl-prolyl cis-trans isomerase signature. 716540004980 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 716540004981 Signal peptide predicted for EAM_0997 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.787 between residues 23 and 24 716540004982 PS00017 ATP/GTP-binding site motif A (P-loop). 716540004983 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 716540004984 active site 716540004985 HMMPfam hit to PF03061, Thioesterase superfamily, score 5.3e-19 716540004986 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 716540004987 Ligand Binding Site [chemical binding]; other site 716540004988 PS00190 Cytochrome c family heme-binding site signature. 716540004989 HMMPfam hit to PF06508, ExsB, score 1.8e-106 716540004990 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 716540004991 EamA-like transporter family; Region: EamA; pfam00892 716540004992 10 transmembrane helices predicted for EAM_1000 by TMHMM2.0 at aa 5-27, 42-59, 72-91, 101-120, 127-144, 154-173, 180-202, 217-239, 246-264 and 269-291 716540004993 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 6.5e-15 716540004994 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 1.3e-26 716540004995 Signal peptide predicted for EAM_1000 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.568 between residues 34 and 35 716540004996 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 716540004997 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 716540004998 putative DNA binding site [nucleotide binding]; other site 716540004999 putative Zn2+ binding site [ion binding]; other site 716540005000 AsnC family; Region: AsnC_trans_reg; pfam01037 716540005001 Predicted helix-turn-helix motif with score 1170.000, SD 3.17 at aa 23-44, sequence LSLQILADAVNLTTTPCWKRLK 716540005002 HMMPfam hit to PF01037, AsnC family, score 5.8e-26 716540005003 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 716540005004 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 716540005005 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716540005006 Walker A/P-loop; other site 716540005007 ATP binding site [chemical binding]; other site 716540005008 Q-loop/lid; other site 716540005009 ABC transporter signature motif; other site 716540005010 Walker B; other site 716540005011 D-loop; other site 716540005012 H-loop/switch region; other site 716540005013 Signal peptide predicted for EAM_1002 by SignalP 2.0 HMM (Signal peptide probability 0.864) with cleavage site probability 0.406 between residues 40 and 41 716540005014 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 4.8e-30 716540005015 6 transmembrane helices predicted for EAM_1002 by TMHMM2.0 at aa 21-40, 55-77, 129-151, 156-178, 246-268 and 278-300 716540005016 HMMPfam hit to PF00005, ABC transporter, score 9.7e-55 716540005017 PS00017 ATP/GTP-binding site motif A (P-loop). 716540005018 PS00211 ABC transporters family signature. 716540005019 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 716540005020 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 716540005021 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 716540005022 Walker A/P-loop; other site 716540005023 ATP binding site [chemical binding]; other site 716540005024 Q-loop/lid; other site 716540005025 ABC transporter signature motif; other site 716540005026 Walker B; other site 716540005027 D-loop; other site 716540005028 H-loop/switch region; other site 716540005029 Signal peptide predicted for EAM_1003 by SignalP 2.0 HMM (Signal peptide probability 0.990) with cleavage site probability 0.617 between residues 37 and 38 716540005030 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 1.9e-30 716540005031 5 transmembrane helices predicted for EAM_1003 by TMHMM2.0 at aa 25-47, 62-84, 138-160, 165-185 and 249-271 716540005032 HMMPfam hit to PF00005, ABC transporter, score 1.6e-49 716540005033 PS00017 ATP/GTP-binding site motif A (P-loop). 716540005034 PS00211 ABC transporters family signature. 716540005035 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 716540005036 Nitrogen regulatory protein P-II; Region: P-II; smart00938 716540005037 HMMPfam hit to PF00543, Nitrogen regulatory protein P-II, score 6.2e-64 716540005038 PS00496 P-II protein urydylation site. 716540005039 PS00638 P-II protein C-terminal region signature. 716540005040 ammonium transporter; Provisional; Region: PRK10666 716540005041 Signal peptide predicted for EAM_1005 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.616 between residues 26 and 27 716540005042 12 transmembrane helices predicted for EAM_1005 by TMHMM2.0 at aa 9-31, 41-63, 68-90, 125-147, 154-176, 191-210, 223-242, 252-274, 286-308, 312-329, 342-364 and 379-401 716540005043 HMMPfam hit to PF00909, Ammonium Transporter Family, score 9.2e-180 716540005044 PS01219 Ammonium transporters signature. 716540005045 acyl-CoA thioesterase II; Provisional; Region: PRK10526 716540005046 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 716540005047 active site 716540005048 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 716540005049 catalytic triad [active] 716540005050 dimer interface [polypeptide binding]; other site 716540005051 HMMPfam hit to PF02551, Acyl-CoA thioesterase, score 1.6e-67 716540005052 HMMPfam hit to PF02551, Acyl-CoA thioesterase, score 1.7e-42 716540005053 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 716540005054 Signal peptide predicted for EAM_1007 by SignalP 2.0 HMM (Signal peptide probability 0.983) with cleavage site probability 0.439 between residues 20 and 21 716540005055 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540005056 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 716540005057 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 716540005058 DNA binding site [nucleotide binding] 716540005059 active site 716540005060 HMMPfam hit to PF01035, 6-O-methylguanine DNA methyltransferase, score 6.9e-33 716540005061 2 transmembrane helices predicted for EAM_1008 by TMHMM2.0 at aa 7-29 and 39-61 716540005062 gene expression modulator; Provisional; Region: PRK10945 716540005063 HMMPfam hit to PF05321, Haemolysin expression modulating protein, score 4.5e-35 716540005064 Hha toxicity attenuator; Provisional; Region: PRK10667 716540005065 PS00014 Endoplasmic reticulum targeting sequence. 716540005066 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 716540005067 HMMPfam hit to PF00444, Ribosomal protein L36, score 3.5e-06 716540005068 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 716540005069 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 716540005070 Protein export membrane protein; Region: SecD_SecF; cl14618 716540005071 Protein export membrane protein; Region: SecD_SecF; cl14618 716540005072 HMMPfam hit to PF00873, AcrB/AcrD/AcrF family, score 0 716540005073 11 transmembrane helices predicted for EAM_1016 by TMHMM2.0 at aa 10-32, 340-359, 369-391, 438-460, 470-492, 541-563, 872-891, 898-920, 925-947, 974-996 and 1006-1028 716540005074 PS00017 ATP/GTP-binding site motif A (P-loop). 716540005075 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 716540005076 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 716540005077 HlyD family secretion protein; Region: HlyD_3; pfam13437 716540005078 HMMPfam hit to PF00529, HlyD family secretion protein, score 2.1e-83 716540005079 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540005080 Signal peptide predicted for EAM_1017 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.931 between residues 24 and 25 716540005081 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 716540005082 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 716540005083 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 716540005084 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 6.4e-21 716540005085 PS01081 Bacterial regulatory proteins, tetR family signature. 716540005086 Predicted helix-turn-helix motif with score 1915.000, SD 5.71 at aa 32-53, sequence TSLADIAAGAGVTRGAIYWHFK 716540005087 HMMPfam hit to PF08361, MAATS-type transcriptional repressor, C-term, score 2.3e-89 716540005088 hypothetical protein; Provisional; Region: PRK11038 716540005089 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 716540005090 3 transmembrane helices predicted for EAM_1020 by TMHMM2.0 at aa 4-21, 28-45 and 60-79 716540005091 Signal peptide predicted for EAM_1020 by SignalP 2.0 HMM (Signal peptide probability 0.719) with cleavage site probability 0.405 between residues 35 and 36 716540005092 Primosomal replication protein priB and priC; Region: priB_priC; cl11483 716540005093 HMMPfam hit to PF07445, Primosomal replication protein priB and pri, score 2.8e-61 716540005094 hypothetical protein; Provisional; Region: PRK10527 716540005095 Signal peptide predicted for EAM_1022 by SignalP 2.0 HMM (Signal peptide probability 0.941) with cleavage site probability 0.546 between residues 35 and 36 716540005096 3 transmembrane helices predicted for EAM_1022 by TMHMM2.0 at aa 5-27, 78-97 and 99-118 716540005097 HMMPfam hit to PF04304, Protein of unknown function (DUF454), score 6.4e-26 716540005098 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 716540005099 active site 716540005100 HMMPfam hit to PF00156, Phosphoribosyl transferase domain, score 4e-47 716540005101 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 716540005102 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 716540005103 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716540005104 Walker A motif; other site 716540005105 ATP binding site [chemical binding]; other site 716540005106 Walker B motif; other site 716540005107 arginine finger; other site 716540005108 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 716540005109 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 716540005110 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 716540005111 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 2.2e-09 716540005112 PS00017 ATP/GTP-binding site motif A (P-loop). 716540005113 PS00215 Mitochondrial energy transfer proteins signature. 716540005114 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 716540005115 hypothetical protein; Validated; Region: PRK00153 716540005116 HMMPfam hit to PF02575, Uncharacterised BCR, YbaB family COG0718, score 3.9e-47 716540005117 recombination protein RecR; Reviewed; Region: recR; PRK00076 716540005118 RecR protein; Region: RecR; pfam02132 716540005119 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 716540005120 putative active site [active] 716540005121 putative metal-binding site [ion binding]; other site 716540005122 tetramer interface [polypeptide binding]; other site 716540005123 HMMPfam hit to PF02132, RecR protein, score 2.2e-17 716540005124 PS01300 RecR protein signature. 716540005125 HMMPfam hit to PF01751, Toprim domain, score 2.6e-21 716540005126 heat shock protein 90; Provisional; Region: PRK05218 716540005127 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716540005128 ATP binding site [chemical binding]; other site 716540005129 Mg2+ binding site [ion binding]; other site 716540005130 G-X-G motif; other site 716540005131 PS00298 Heat shock hsp90 proteins family signature. 716540005132 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 3.1e-14 716540005133 HMMPfam hit to PF00183, Hsp90 protein, score 3.4e-82 716540005134 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 716540005135 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716540005136 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 716540005137 dimerization interface [polypeptide binding]; other site 716540005138 HMMPfam hit to PF03466, LysR substrate binding domain, score 6.3e-14 716540005139 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 6.7e-21 716540005140 PS00044 Bacterial regulatory proteins, lysR family signature. 716540005141 Predicted helix-turn-helix motif with score 1791.000, SD 5.29 at aa 20-41, sequence QSFSRAAQSLNVTHSAVSHQIK 716540005142 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 716540005143 Ligand Binding Site [chemical binding]; other site 716540005144 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 716540005145 nudix motif; other site 716540005146 HMMPfam hit to PF00293, NUDIX domain, score 1.7e-09 716540005147 PS00893 mutT domain signature. 716540005148 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 716540005149 10 transmembrane helices predicted for EAM_1032 by TMHMM2.0 at aa 7-29, 35-57, 74-91, 96-118, 125-147, 151-173, 180-202, 212-234, 241-260 and 265-287 716540005150 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 4.7e-05 716540005151 adenylate kinase; Reviewed; Region: adk; PRK00279 716540005152 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 716540005153 AMP-binding site [chemical binding]; other site 716540005154 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 716540005155 HMMPfam hit to PF00406, Adenylate kinase, score 1.7e-98 716540005156 PS00113 Adenylate kinase signature. 716540005157 HMMPfam hit to PF05191, Adenylate kinase, active site lid, score 4.7e-20 716540005158 ferrochelatase; Reviewed; Region: hemH; PRK00035 716540005159 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 716540005160 C-terminal domain interface [polypeptide binding]; other site 716540005161 active site 716540005162 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 716540005163 active site 716540005164 N-terminal domain interface [polypeptide binding]; other site 716540005165 HMMPfam hit to PF00762, Ferrochelatase, score 9.7e-135 716540005166 PS00534 Ferrochelatase signature. 716540005167 inosine/guanosine kinase; Provisional; Region: PRK15074 716540005168 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 716540005169 HMMPfam hit to PF00294, pfkB family carbohydrate kinase, score 1.8e-17 716540005170 PS00584 pfkB family of carbohydrate kinases signature 2. 716540005171 putative cation:proton antiport protein; Provisional; Region: PRK10669 716540005172 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 716540005173 TrkA-N domain; Region: TrkA_N; pfam02254 716540005174 HMMPfam hit to PF02254, TrkA-N domain, score 3e-32 716540005175 11 transmembrane helices predicted for EAM_1037 by TMHMM2.0 at aa 4-26, 33-52, 56-78, 87-109, 114-136, 149-171, 184-206, 226-248, 302-324, 336-358 and 368-387 716540005176 HMMPfam hit to PF00999, Sodium/hydrogen exchanger family, score 3.8e-87 716540005177 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540005178 Major Facilitator Superfamily; Region: MFS_1; pfam07690 716540005179 putative substrate translocation pore; other site 716540005180 10 transmembrane helices predicted for EAM_1038 by TMHMM2.0 at aa 59-81, 96-130, 151-173, 178-200, 230-252, 267-286, 293-312, 316-338, 350-372 and 376-398 716540005181 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 3.7e-41 716540005182 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 716540005183 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 716540005184 active site 716540005185 metal binding site [ion binding]; metal-binding site 716540005186 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 716540005187 Signal peptide predicted for EAM_1039 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.512 between residues 25 and 26 716540005188 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 3.5e-19 716540005189 PS00786 5'-nucleotidase signature 2. 716540005190 HMMPfam hit to PF02872, 5'-nucleotidase, C-terminal domain, score 1.2e-46 716540005191 Predicted membrane protein [Function unknown]; Region: COG4125 716540005192 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 716540005193 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 716540005194 HMMPfam hit to PF05232, Bacterial Transmembrane Pair family, score 5.2e-29 716540005195 4 transmembrane helices predicted for EAM_1040 by TMHMM2.0 at aa 13-30, 35-57, 78-97 and 107-129 716540005196 HMMPfam hit to PF05232, Bacterial Transmembrane Pair family, score 7.1e-33 716540005197 Signal peptide predicted for EAM_1040 by SignalP 2.0 HMM (Signal peptide probability 0.900) with cleavage site probability 0.896 between residues 31 and 32 716540005198 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716540005199 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716540005200 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 716540005201 dimerization interface [polypeptide binding]; other site 716540005202 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 4.8e-19 716540005203 Predicted helix-turn-helix motif with score 1436.000, SD 4.08 at aa 18-39, sequence GSFSAAARALRKSQSTISTAVA 716540005204 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.5e-26 716540005205 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 716540005206 putative deacylase active site [active] 716540005207 HMMPfam hit to PF04073, YbaK / prolyl-tRNA synthetases associated do, score 8.7e-67 716540005208 TraB family; Region: TraB; cl12050 716540005209 HMMPfam hit to PF07446, GumN protein, score 2.5e-05 716540005210 copper exporting ATPase; Provisional; Region: copA; PRK10671 716540005211 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 716540005212 metal-binding site [ion binding] 716540005213 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 716540005214 metal-binding site [ion binding] 716540005215 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 716540005216 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716540005217 motif II; other site 716540005218 8 transmembrane helices predicted for EAM_1044 by TMHMM2.0 at aa 186-205, 220-242, 255-274, 284-303, 437-459, 464-486, 779-798 and 803-825 716540005219 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 7.9e-40 716540005220 PS01229 Hypothetical cof family signature 2. 716540005221 PS00154 E1-E2 ATPases phosphorylation site. 716540005222 HMMPfam hit to PF00122, E1-E2 ATPase, score 7.7e-89 716540005223 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 716540005224 HMMPfam hit to PF00403, Heavy-metal-associated domain, score 5.3e-12 716540005225 PS01047 Heavy-metal-associated domain. 716540005226 HMMPfam hit to PF00403, Heavy-metal-associated domain, score 3.1e-07 716540005227 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 716540005228 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 716540005229 DNA binding residues [nucleotide binding] 716540005230 dimer interface [polypeptide binding]; other site 716540005231 copper binding site [ion binding]; other site 716540005232 Predicted helix-turn-helix motif with score 1386.000, SD 3.91 at aa 1-22, sequence MNIGDVAKKTGLTSKAIRFYEE 716540005233 HMMPfam hit to PF00376, MerR family regulatory protein, score 7.8e-14 716540005234 PS00552 Bacterial regulatory proteins, merR family signature. 716540005235 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 716540005236 HMMPfam hit to PF01957, Nodulation efficiency protein D (NfeD), score 2.2e-37 716540005237 3 transmembrane helices predicted for EAM_1046 by TMHMM2.0 at aa 10-27, 32-51 and 55-72 716540005238 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 716540005239 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 716540005240 HMMPfam hit to PF01145, SPFH domain / Band, score 3.4e-84 716540005241 PS01270 Band 7 protein family signature. 716540005242 1 transmembrane helix predicted for EAM_1047 by TMHMM2.0 at aa 7-29 716540005243 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 716540005244 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 716540005245 HMMPfam hit to PF00085, Thioredoxin, score 5.6e-20 716540005246 oxidoreductase; Provisional; Region: PRK08017 716540005247 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 716540005248 NADP binding site [chemical binding]; other site 716540005249 active site 716540005250 steroid binding site; other site 716540005251 HMMPfam hit to PF00106, short chain dehydrogenase, score 2.6e-22 716540005252 PS00061 Short-chain dehydrogenases/reductases family signature. 716540005253 Signal peptide predicted for EAM_1049 by SignalP 2.0 HMM (Signal peptide probability 0.949) with cleavage site probability 0.893 between residues 19 and 20 716540005254 Colicin immunity protein; Region: Colicin_im; pfam03857 716540005255 PS00228 Tubulin-beta mRNA autoregulation signal. 716540005256 4 transmembrane helices predicted for EAM_1051 by TMHMM2.0 at aa 20-37, 72-89, 102-124 and 144-166 716540005257 HMMPfam hit to PF03857, Colicin immunity protein, score 4.8e-31 716540005258 Colicin pore forming domain; Region: Colicin; pfam01024 716540005259 HMMPfam hit to PF01024, Colicin pore forming domain, score 1.1e-77 716540005260 2 transmembrane helices predicted for EAM_1052 by TMHMM2.0 at aa 148-170 and 174-196 716540005261 PS00276 Channel forming colicins signature. 716540005262 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 716540005263 active site 716540005264 catalytic triad [active] 716540005265 oxyanion hole [active] 716540005266 switch loop; other site 716540005267 HMMPfam hit to PF00657, GDSL-like Lipase/Acylhydrolase, score 7.7e-36 716540005268 PS01098 Lipolytic enzymes ''G-D-S-L'' family, serine active site. 716540005269 1 transmembrane helix predicted for EAM_1056 by TMHMM2.0 at aa 12-34 716540005270 Signal peptide predicted for EAM_1056 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.982 between residues 26 and 27 716540005271 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 716540005272 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 716540005273 Walker A/P-loop; other site 716540005274 ATP binding site [chemical binding]; other site 716540005275 Q-loop/lid; other site 716540005276 ABC transporter signature motif; other site 716540005277 Walker B; other site 716540005278 D-loop; other site 716540005279 H-loop/switch region; other site 716540005280 HMMPfam hit to PF00005, ABC transporter, score 3.2e-56 716540005281 PS00017 ATP/GTP-binding site motif A (P-loop). 716540005282 PS00211 ABC transporters family signature. 716540005283 FtsX-like permease family; Region: FtsX; pfam02687 716540005284 Signal peptide predicted for EAM_1058 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.366 between residues 33 and 34 716540005285 10 transmembrane helices predicted for EAM_1058 by TMHMM2.0 at aa 13-35, 243-262, 291-313, 333-355, 376-398, 408-430, 451-473, 676-698, 731-753 and 768-790 716540005286 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540005287 HMMPfam hit to PF02687, Predicted permease, score 3.9e-10 716540005288 HMMPfam hit to PF02687, Predicted permease, score 9.9e-11 716540005289 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 716540005290 ATP-grasp domain; Region: ATP-grasp; pfam02222 716540005291 HMMPfam hit to PF02222, ATP-grasp domain, score 2.2e-84 716540005292 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 716540005293 HMMPfam hit to PF00731, AIR carboxylase, score 3.2e-99 716540005294 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 716540005295 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 716540005296 putative active site [active] 716540005297 putative metal binding site [ion binding]; other site 716540005298 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 1e-13 716540005299 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 716540005300 substrate binding site [chemical binding]; other site 716540005301 HMMPfam hit to PF00160, Cyclophilin type peptidyl-prolyl cis-tr, score 9.4e-54 716540005302 PS00170 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. 716540005303 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 716540005304 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 716540005305 active site 716540005306 HIGH motif; other site 716540005307 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 716540005308 KMSKS motif; other site 716540005309 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 716540005310 tRNA binding surface [nucleotide binding]; other site 716540005311 anticodon binding site; other site 716540005312 HMMPfam hit to PF01406, tRNA synthetases class I (C) catalytic d, score 2.1e-208 716540005313 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 716540005314 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 716540005315 NAD binding site [chemical binding]; other site 716540005316 substrate binding site [chemical binding]; other site 716540005317 catalytic Zn binding site [ion binding]; other site 716540005318 tetramer interface [polypeptide binding]; other site 716540005319 structural Zn binding site [ion binding]; other site 716540005320 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 1.7e-43 716540005321 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like domain, score 4.8e-41 716540005322 PS00059 Zinc-containing alcohol dehydrogenases signature. 716540005323 PS00190 Cytochrome c family heme-binding site signature. 716540005324 ribosome-associated protein; Provisional; Region: PRK11507 716540005325 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 716540005326 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 716540005327 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 716540005328 homodimer interface [polypeptide binding]; other site 716540005329 NADP binding site [chemical binding]; other site 716540005330 substrate binding site [chemical binding]; other site 716540005331 HMMPfam hit to PF02882, Tetrahydrofolate dehydrogenase/cyclohyd, score 4.4e-111 716540005332 PS00767 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 2. 716540005333 HMMPfam hit to PF00763, Tetrahydrofolate dehydrogenase/cyclohyd, score 2.2e-66 716540005334 PS00766 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 1. 716540005335 PS00017 ATP/GTP-binding site motif A (P-loop). 716540005336 Signal peptide predicted for EAM_1073 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.915 between residues 22 and 23 716540005337 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540005338 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 716540005339 HMMPfam hit to PF02566, OsmC-like protein, score 1.3e-27 716540005340 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 716540005341 Signal peptide predicted for EAM_1077 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 25 and 26 716540005342 2 transmembrane helices predicted for EAM_1077 by TMHMM2.0 at aa 5-22 and 122-144 716540005343 1 transmembrane helix predicted for EAM_1078 by TMHMM2.0 at aa 20-42 716540005344 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540005345 HMMPfam hit to PF07665, M penetrans paralogue family, score 0.0011 716540005346 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040 716540005347 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 716540005348 HMMPfam hit to PF02574, Homocysteine S-methyltransferase, score 1.3e-27 716540005349 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 716540005350 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 716540005351 Signal peptide predicted for EAM_1081 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 29 and 30 716540005352 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540005353 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 1.6e-63 716540005354 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 716540005355 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540005356 dimer interface [polypeptide binding]; other site 716540005357 conserved gate region; other site 716540005358 putative PBP binding loops; other site 716540005359 ABC-ATPase subunit interface; other site 716540005360 Signal peptide predicted for EAM_1082 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.623 between residues 48 and 49 716540005361 6 transmembrane helices predicted for EAM_1082 by TMHMM2.0 at aa 21-43, 112-134, 154-176, 191-208, 249-271 and 300-322 716540005362 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.1e-31 716540005363 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 716540005364 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540005365 dimer interface [polypeptide binding]; other site 716540005366 conserved gate region; other site 716540005367 ABC-ATPase subunit interface; other site 716540005368 Signal peptide predicted for EAM_1083 by SignalP 2.0 HMM (Signal peptide probability 0.986) with cleavage site probability 0.729 between residues 24 and 25 716540005369 5 transmembrane helices predicted for EAM_1083 by TMHMM2.0 at aa 6-28, 72-94, 109-140, 196-218 and 233-255 716540005370 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 3.2e-43 716540005371 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 716540005372 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 716540005373 Walker A/P-loop; other site 716540005374 ATP binding site [chemical binding]; other site 716540005375 Q-loop/lid; other site 716540005376 ABC transporter signature motif; other site 716540005377 Walker B; other site 716540005378 D-loop; other site 716540005379 H-loop/switch region; other site 716540005380 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 716540005381 Walker A/P-loop; other site 716540005382 ATP binding site [chemical binding]; other site 716540005383 Q-loop/lid; other site 716540005384 ABC transporter signature motif; other site 716540005385 Walker B; other site 716540005386 D-loop; other site 716540005387 H-loop/switch region; other site 716540005388 HMMPfam hit to PF00005, ABC transporter, score 2.6e-46 716540005389 PS00017 ATP/GTP-binding site motif A (P-loop). 716540005390 PS00211 ABC transporters family signature. 716540005391 HMMPfam hit to PF00005, ABC transporter, score 2.1e-58 716540005392 PS00017 ATP/GTP-binding site motif A (P-loop). 716540005393 PS00211 ABC transporters family signature. 716540005394 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 716540005395 HMMPfam hit to PF00560, Leucine Rich Repeat, score 8 716540005396 HMMPfam hit to PF00560, Leucine Rich Repeat, score 9.3 716540005397 HMMPfam hit to PF00560, Leucine Rich Repeat, score 3 716540005398 Signal peptide predicted for EAM_1086 by SignalP 2.0 HMM (Signal peptide probability 0.872) with cleavage site probability 0.283 between residues 35 and 36 716540005399 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540005400 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 716540005401 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 716540005402 N-terminal plug; other site 716540005403 ligand-binding site [chemical binding]; other site 716540005404 Signal peptide predicted for EAM_1087 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.535 between residues 25 and 26 716540005405 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 4.3e-24 716540005406 HMMPfam hit to PF00593, TonB dependent receptor, score 2.1e-32 716540005407 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 716540005408 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 716540005409 Trp docking motif [polypeptide binding]; other site 716540005410 putative active site [active] 716540005411 Signal peptide predicted for EAM_1088 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.960 between residues 26 and 27 716540005412 5 transmembrane helices predicted for EAM_1088 by TMHMM2.0 at aa 9-31, 35-54, 61-78, 93-110 and 115-137 716540005413 HMMPfam hit to PF01011, PQQ enzyme repeat, score 5.6e-08 716540005414 HMMPfam hit to PF01011, PQQ enzyme repeat, score 2e-05 716540005415 PS00364 Bacterial quinoprotein dehydrogenases signature 2. 716540005416 HMMPfam hit to PF01011, PQQ enzyme repeat, score 1.6e-05 716540005417 HMMPfam hit to PF01011, PQQ enzyme repeat, score 2.2e-07 716540005418 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 716540005419 HMMPfam hit to PF01243, Pyridoxamine 5'-phosphate oxidase, score 0.0041 716540005420 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 716540005421 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 716540005422 inhibitor-cofactor binding pocket; inhibition site 716540005423 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716540005424 catalytic residue [active] 716540005425 HMMPfam hit to PF01053, Cys/Met metabolism PLP-dependent enzy, score 0.00067 716540005426 HMMPfam hit to PF01041, DegT/DnrJ/EryC1/StrS aminotransferase, score 2.1e-176 716540005427 HMMPfam hit to PF01212, Beta-eliminating lyase, score 9e-06 716540005428 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 716540005429 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 716540005430 Ligand binding site; other site 716540005431 Putative Catalytic site; other site 716540005432 DXD motif; other site 716540005433 HMMPfam hit to PF00535, Glycosyl transferase family, score 3.3e-33 716540005434 2 transmembrane helices predicted for EAM_1091 by TMHMM2.0 at aa 237-259 and 274-296 716540005435 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 716540005436 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 716540005437 active site 716540005438 substrate binding site [chemical binding]; other site 716540005439 cosubstrate binding site; other site 716540005440 catalytic site [active] 716540005441 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 716540005442 active site 716540005443 hexamer interface [polypeptide binding]; other site 716540005444 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 716540005445 NAD binding site [chemical binding]; other site 716540005446 substrate binding site [chemical binding]; other site 716540005447 active site 716540005448 HMMPfam hit to PF00551, Formyl transferase, score 2e-12 716540005449 HMMPfam hit to PF02911, Formyl transferase, C-terminal domain, score 4e-28 716540005450 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase fa, score 5.2e-43 716540005451 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 716540005452 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 716540005453 putative active site [active] 716540005454 putative catalytic site [active] 716540005455 putative Zn binding site [ion binding]; other site 716540005456 HMMPfam hit to PF01522, Polysaccharide deacetylase, score 0.0028 716540005457 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 716540005458 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 716540005459 HMMPfam hit to PF02366, Dolichyl-phosphate-mannose-protein mannosylt, score 2.5e-44 716540005460 11 transmembrane helices predicted for EAM_1094 by TMHMM2.0 at aa 7-29, 81-103, 112-134, 175-197, 204-226, 257-279, 292-309, 313-335, 347-369, 384-403 and 408-427 716540005461 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 716540005462 HMMPfam hit to PF00893, Small Multidrug Resistance protein, score 6.3e-05 716540005463 Signal peptide predicted for EAM_1095 by SignalP 2.0 HMM (Signal peptide probability 0.983) with cleavage site probability 0.481 between residues 20 and 21 716540005464 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540005465 3 transmembrane helices predicted for EAM_1095 by TMHMM2.0 at aa 32-54, 58-80 and 85-107 716540005466 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 716540005467 Signal peptide predicted for EAM_1096 by SignalP 2.0 HMM (Signal peptide probability 0.815) with cleavage site probability 0.655 between residues 16 and 17 716540005468 4 transmembrane helices predicted for EAM_1096 by TMHMM2.0 at aa 2-24, 44-66, 73-95 and 100-122 716540005469 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 716540005470 1 transmembrane helix predicted for EAM_1097 by TMHMM2.0 at aa 62-81 716540005471 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 716540005472 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 716540005473 HMMPfam hit to PF02322, Cytochrome oxidase subunit II, score 6e-146 716540005474 8 transmembrane helices predicted for EAM_1098 by TMHMM2.0 at aa 5-23, 74-96, 117-139, 154-176, 197-216, 231-248, 260-282 and 302-324 716540005475 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 716540005476 HMMPfam hit to PF01654, Bacterial Cytochrome Ubiquinol Oxidase, score 5.7e-226 716540005477 9 transmembrane helices predicted for EAM_1099 by TMHMM2.0 at aa 20-42, 55-77, 97-119, 126-148, 186-208, 221-238, 323-345, 358-380 and 407-429 716540005478 Signal peptide predicted for EAM_1101 by SignalP 2.0 HMM (Signal peptide probability 0.811) with cleavage site probability 0.488 between residues 31 and 32 716540005479 1 transmembrane helix predicted for EAM_1101 by TMHMM2.0 at aa 13-35 716540005480 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540005481 2 transmembrane helices predicted for EAM_1102 by TMHMM2.0 at aa 275-297 and 312-334 716540005482 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 716540005483 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 716540005484 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 716540005485 HMMPfam hit to PF00455, Bacterial regulatory proteins, deoR family, score 3.1e-35 716540005486 HMMPfam hit to PF08220, DeoR-like helix-turn-helix domain, score 7.7e-17 716540005487 HMMPfam hit to PF08279, HTH domain, score 9e-11 716540005488 Predicted helix-turn-helix motif with score 1648.000, SD 4.80 at aa 20-41, sequence VSIAELSERLAVSHMTIRRDLQ 716540005489 PS00894 Bacterial regulatory proteins, deoR family signature. 716540005490 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 716540005491 Signal peptide predicted for EAM_1106 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.583 between residues 20 and 21 716540005492 HMMPfam hit to PF03446, NAD binding domain of 6-phosphogluconat, score 2.8e-10 716540005493 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 716540005494 HMMPfam hit to PF07005, Protein of unknown function, DUF1537, score 6.1e-91 716540005495 putative aldolase; Validated; Region: PRK08130 716540005496 intersubunit interface [polypeptide binding]; other site 716540005497 active site 716540005498 Zn2+ binding site [ion binding]; other site 716540005499 HMMPfam hit to PF00596, Class II Aldolase and Adducin N-terminal, score 2.1e-59 716540005500 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 716540005501 HMMPfam hit to PF01261, Xylose isomerase-like TIM barrel, score 4.8e-50 716540005502 2 transmembrane helices predicted for EAM_1110 by TMHMM2.0 at aa 22-44 and 51-73 716540005503 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 716540005504 Signal peptide predicted for EAM_1115 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.984 between residues 23 and 24 716540005505 HMMPfam hit to PF07017, Antimicrobial peptide resistance and lipid A, score 2.4e-107 716540005506 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 716540005507 DNA-binding site [nucleotide binding]; DNA binding site 716540005508 RNA-binding motif; other site 716540005509 HMMPfam hit to PF00313, 'Cold-shock' DNA-binding domain, score 2.9e-44 716540005510 PS00352 'Cold-shock' DNA-binding domain signature. 716540005511 Predicted amidohydrolase [General function prediction only]; Region: COG0388 716540005512 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 716540005513 putative active site [active] 716540005514 catalytic triad [active] 716540005515 putative dimer interface [polypeptide binding]; other site 716540005516 HMMPfam hit to PF00795, Carbon-nitrogen hydrolase, score 3.9e-33 716540005517 PS01227 Uncharacterized protein family UPF0012 signature. 716540005518 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 716540005519 HMMPfam hit to PF02416, mttA/Hcf106 family, score 2.4e-07 716540005520 1 transmembrane helix predicted for EAM_1118 by TMHMM2.0 at aa 4-21 716540005521 lipoyl synthase; Provisional; Region: PRK05481 716540005522 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 716540005523 FeS/SAM binding site; other site 716540005524 HMMPfam hit to PF04055, Radical SAM superfamily, score 2.5e-23 716540005525 lipoate-protein ligase B; Provisional; Region: PRK14342 716540005526 HMMPfam hit to PF03099, Biotin/lipoate A/B protein ligase famil, score 7e-15 716540005527 PS01313 Lipoate-protein ligase B signature. 716540005528 hypothetical protein; Provisional; Region: PRK04998 716540005529 HMMPfam hit to PF04359, Protein of unknown function (DUF493), score 2.3e-53 716540005530 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 716540005531 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 716540005532 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 716540005533 HMMPfam hit to PF07943, Penicillin-binding protein 5, C-termina, score 2.3e-38 716540005534 HMMPfam hit to PF00768, D-alanyl-D-alanine carboxypeptidase, score 8.5e-147 716540005535 Signal peptide predicted for EAM_1122 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.783 between residues 29 and 30 716540005536 rare lipoprotein A; Provisional; Region: PRK10672 716540005537 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 716540005538 Sporulation related domain; Region: SPOR; pfam05036 716540005539 HMMPfam hit to PF05036, Sporulation related domain, score 2.6e-16 716540005540 HMMPfam hit to PF03330, Rare lipoprotein A (RlpA)-like double-psi be, score 1.5e-35 716540005541 Signal peptide predicted for EAM_1123 by SignalP 2.0 HMM (Signal peptide probability 0.981) with cleavage site probability 0.321 between residues 22 and 23 716540005542 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540005543 cell wall shape-determining protein; Provisional; Region: PRK10794 716540005544 HMMPfam hit to PF01098, Cell cycle protein, score 7.4e-173 716540005545 9 transmembrane helices predicted for EAM_1124 by TMHMM2.0 at aa 15-37, 50-67, 77-96, 139-156, 160-177, 184-203, 272-294, 306-328 and 338-360 716540005546 PS00428 Cell cycle proteins ftsW / rodA / spoVE signature. 716540005547 Signal peptide predicted for EAM_1124 by SignalP 2.0 HMM (Signal peptide probability 0.987) with cleavage site probability 0.921 between residues 40 and 41 716540005548 penicillin-binding protein 2; Provisional; Region: PRK10795 716540005549 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 716540005550 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 716540005551 HMMPfam hit to PF00905, Penicillin binding protein transpeptid, score 1.1e-93 716540005552 HMMPfam hit to PF03717, Penicillin-binding Protein dimerisatio, score 3.4e-65 716540005553 1 transmembrane helix predicted for EAM_1125 by TMHMM2.0 at aa 21-43 716540005554 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 716540005555 HMMPfam hit to PF02590, Uncharacterized ACR, COG1576, score 2e-77 716540005556 ribosome-associated protein; Provisional; Region: PRK11538 716540005557 HMMPfam hit to PF02410, Domain of unknown function DUF143, score 5.8e-47 716540005558 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 716540005559 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 716540005560 active site 716540005561 (T/H)XGH motif; other site 716540005562 HMMPfam hit to PF01467, Cytidylyltransferase, score 1e-54 716540005563 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 716540005564 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 716540005565 HMMPfam hit to PF06144, DNA polymerase III, delta subunit, score 1.1e-117 716540005566 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 716540005567 HMMPfam hit to PF04390, Rare lipoprotein B family, score 4e-63 716540005568 1 transmembrane helix predicted for EAM_1130 by TMHMM2.0 at aa 10-29 716540005569 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540005570 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 716540005571 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 716540005572 HIGH motif; other site 716540005573 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 716540005574 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 716540005575 active site 716540005576 KMSKS motif; other site 716540005577 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 716540005578 tRNA binding surface [nucleotide binding]; other site 716540005579 HMMPfam hit to PF08264, Anticodon-binding domain, score 7e-07 716540005580 PS00216 Sugar transport proteins signature 1. 716540005581 HMMPfam hit to PF00133, tRNA synthetases class I (I, L, M and V), score 9.5e-14 716540005582 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 716540005583 hypothetical protein; Provisional; Region: PRK11032 716540005584 HMMPfam hit to PF07295, Protein of unknown function (DUF1451), score 7.1e-84 716540005585 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 716540005586 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 716540005587 Walker A/P-loop; other site 716540005588 ATP binding site [chemical binding]; other site 716540005589 Q-loop/lid; other site 716540005590 ABC transporter signature motif; other site 716540005591 Walker B; other site 716540005592 D-loop; other site 716540005593 H-loop/switch region; other site 716540005594 HMMPfam hit to PF00005, ABC transporter, score 7.6e-62 716540005595 PS00211 ABC transporters family signature. 716540005596 PS00017 ATP/GTP-binding site motif A (P-loop). 716540005597 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 716540005598 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540005599 dimer interface [polypeptide binding]; other site 716540005600 conserved gate region; other site 716540005601 putative PBP binding loops; other site 716540005602 ABC-ATPase subunit interface; other site 716540005603 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 2.4e-31 716540005604 5 transmembrane helices predicted for EAM_1134 by TMHMM2.0 at aa 15-37, 58-80, 95-112, 155-177 and 197-219 716540005605 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 716540005606 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540005607 dimer interface [polypeptide binding]; other site 716540005608 conserved gate region; other site 716540005609 putative PBP binding loops; other site 716540005610 ABC-ATPase subunit interface; other site 716540005611 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 716540005612 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.9e-37 716540005613 4 transmembrane helices predicted for EAM_1135 by TMHMM2.0 at aa 31-53, 66-88, 108-127 and 211-233 716540005614 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 716540005615 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 716540005616 substrate binding pocket [chemical binding]; other site 716540005617 membrane-bound complex binding site; other site 716540005618 hinge residues; other site 716540005619 HMMPfam hit to PF00497, Bacterial extracellular solute-binding prot, score 8.7e-57 716540005620 Signal peptide predicted for EAM_1136 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 22 and 23 716540005621 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 716540005622 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 716540005623 putative active site [active] 716540005624 catalytic triad [active] 716540005625 putative dimer interface [polypeptide binding]; other site 716540005626 8 transmembrane helices predicted for EAM_1137 by TMHMM2.0 at aa 12-29, 33-50, 57-79, 89-111, 124-143, 163-185, 187-206 and 486-503 716540005627 HMMPfam hit to PF00795, Carbon-nitrogen hydrolase, score 2.2e-36 716540005628 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 716540005629 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 716540005630 Transporter associated domain; Region: CorC_HlyC; smart01091 716540005631 HMMPfam hit to PF03471, Transporter associated domain, score 1.2e-28 716540005632 HMMPfam hit to PF00571, CBS domain pair, score 4.5e-30 716540005633 metal-binding heat shock protein; Provisional; Region: PRK00016 716540005634 HMMPfam hit to PF02130, Uncharacterized protein family UPF0054, score 2.2e-51 716540005635 PS01306 Uncharacterized protein family UPF0054 signature. 716540005636 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 716540005637 PhoH-like protein; Region: PhoH; pfam02562 716540005638 HMMPfam hit to PF02562, PhoH-like protein, score 2.1e-150 716540005639 PS00017 ATP/GTP-binding site motif A (P-loop). 716540005640 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 716540005641 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 716540005642 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 716540005643 FeS/SAM binding site; other site 716540005644 TRAM domain; Region: TRAM; pfam01938 716540005645 HMMPfam hit to PF01938, TRAM domain, score 1.5e-18 716540005646 HMMPfam hit to PF04055, Radical SAM superfamily, score 5e-31 716540005647 PS01278 Uncharacterized protein family UPF0004 signature. 716540005648 HMMPfam hit to PF00919, Uncharacterized protein family UPF0004, score 2.4e-50 716540005649 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 716540005650 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 716540005651 Signal peptide predicted for EAM_1142 by SignalP 2.0 HMM (Signal peptide probability 0.921) with cleavage site probability 0.729 between residues 23 and 24 716540005652 HMMPfam hit to PF01494, FAD binding domain, score 3.1e-09 716540005653 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 2e-07 716540005654 asparagine synthetase B; Provisional; Region: asnB; PRK09431 716540005655 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 716540005656 active site 716540005657 dimer interface [polypeptide binding]; other site 716540005658 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 716540005659 Ligand Binding Site [chemical binding]; other site 716540005660 Molecular Tunnel; other site 716540005661 HMMPfam hit to PF00733, Asparagine synthase, score 9.2e-113 716540005662 HMMPfam hit to PF00310, Glutamine amidotransferases class-II, score 3e-21 716540005663 PS00443 Glutamine amidotransferases class-II active site. 716540005664 UMP phosphatase; Provisional; Region: PRK10444 716540005665 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716540005666 active site 716540005667 motif I; other site 716540005668 motif II; other site 716540005669 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716540005670 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 1.1e-10 716540005671 MarR family; Region: MarR; pfam01047 716540005672 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 716540005673 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 716540005674 nucleotide binding site [chemical binding]; other site 716540005675 HMMPfam hit to PF00480, ROK family, score 5.6e-74 716540005676 PS01125 ROK family signature. 716540005677 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 716540005678 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 716540005679 active site 716540005680 dimer interface [polypeptide binding]; other site 716540005681 HMMPfam hit to PF01979, Amidohydrolase family, score 6.4e-41 716540005682 HMMPfam hit to PF07969, Amidohydrolase family, score 0.0012 716540005683 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 716540005684 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 716540005685 active site 716540005686 trimer interface [polypeptide binding]; other site 716540005687 allosteric site; other site 716540005688 active site lid [active] 716540005689 hexamer (dimer of trimers) interface [polypeptide binding]; other site 716540005690 HMMPfam hit to PF01182, Glucosamine-6-phosphate isomerases/6-, score 3.1e-190 716540005691 PS01161 Glucosamine/galactosamine-6-phosphate isomerases signature. 716540005692 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 716540005693 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 716540005694 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 716540005695 active site turn [active] 716540005696 phosphorylation site [posttranslational modification] 716540005697 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 716540005698 HPr interaction site; other site 716540005699 glycerol kinase (GK) interaction site [polypeptide binding]; other site 716540005700 active site 716540005701 phosphorylation site [posttranslational modification] 716540005702 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 1.4e-97 716540005703 11 transmembrane helices predicted for EAM_1148 by TMHMM2.0 at aa 13-30, 40-62, 69-91, 96-118, 131-153, 163-185, 192-214, 229-251, 258-280, 295-317 and 337-359 716540005704 PS00044 Bacterial regulatory proteins, lysR family signature. 716540005705 HMMPfam hit to PF00367, phosphotransferase system, EIIB, score 2.6e-14 716540005706 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 716540005707 HMMPfam hit to PF00358, phosphoenolpyruvate-dependent sugar phosph, score 1.6e-70 716540005708 PS00371 PTS EIIA domains phosphorylation site signature 1. 716540005709 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 716540005710 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 716540005711 active site 716540005712 HIGH motif; other site 716540005713 nucleotide binding site [chemical binding]; other site 716540005714 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 716540005715 KMSKS motif; other site 716540005716 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 716540005717 HMMPfam hit to PF00749, tRNA synthetases class I (E and Q), ca, score 3.1e-171 716540005718 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 716540005719 HMMPfam hit to PF03950, tRNA synthetases class I (E and Q), an, score 1.1e-101 716540005720 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 716540005721 aromatic amino acid transport protein; Region: araaP; TIGR00837 716540005722 Signal peptide predicted for EAM_1150 by SignalP 2.0 HMM (Signal peptide probability 0.720) with cleavage site probability 0.383 between residues 62 and 63 716540005723 HMMPfam hit to PF03222, Tryptophan/tyrosine permease family, score 2.4e-183 716540005724 11 transmembrane helices predicted for EAM_1150 by TMHMM2.0 at aa 13-35, 40-62, 91-113, 123-145, 152-174, 194-216, 228-250, 283-305, 318-340, 345-367 and 387-409 716540005725 PS00594 Aromatic amino acids permeases signature. 716540005726 ferric uptake regulator; Provisional; Region: fur; PRK09462 716540005727 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 716540005728 metal binding site 2 [ion binding]; metal-binding site 716540005729 putative DNA binding helix; other site 716540005730 metal binding site 1 [ion binding]; metal-binding site 716540005731 dimer interface [polypeptide binding]; other site 716540005732 structural Zn2+ binding site [ion binding]; other site 716540005733 HMMPfam hit to PF01475, Ferric uptake regulator family, score 1.4e-71 716540005734 flavodoxin FldA; Validated; Region: PRK09267 716540005735 HMMPfam hit to PF00258, Flavodoxin, score 1.6e-45 716540005736 PS00201 Flavodoxin signature. 716540005737 LexA regulated protein; Provisional; Region: PRK11675 716540005738 HMMPfam hit to PF01402, Ribbon-helix-helix protein, copG family, score 5.7e-07 716540005739 acyl-CoA esterase; Provisional; Region: PRK10673 716540005740 PGAP1-like protein; Region: PGAP1; pfam07819 716540005741 HMMPfam hit to PF00561, alpha/beta hydrolase fold, score 7.7e-19 716540005742 HMMPfam hit to PF07819, PGAP1-like protein, score 5.6e-06 716540005743 replication initiation regulator SeqA; Provisional; Region: PRK11187 716540005744 HMMPfam hit to PF03925, SeqA protein, score 4.8e-109 716540005745 phosphoglucomutase; Validated; Region: PRK07564 716540005746 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 716540005747 active site 716540005748 substrate binding site [chemical binding]; other site 716540005749 metal binding site [ion binding]; metal-binding site 716540005750 HMMPfam hit to PF02878, Phosphoglucomutase/phosphomannomutase, al, score 6.3e-40 716540005751 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 716540005752 HMMPfam hit to PF02879, Phosphoglucomutase/phosphomannomutase, al, score 1.8e-19 716540005753 HMMPfam hit to PF02880, Phosphoglucomutase/phosphomannomutase, al, score 8.7e-30 716540005754 HMMPfam hit to PF00408, Phosphoglucomutase/phosphomannomutase, C-, score 6.2e-12 716540005755 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 716540005756 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716540005757 active site 716540005758 phosphorylation site [posttranslational modification] 716540005759 intermolecular recognition site; other site 716540005760 dimerization interface [polypeptide binding]; other site 716540005761 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 716540005762 DNA binding site [nucleotide binding] 716540005763 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 3.4e-15 716540005764 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.9e-38 716540005765 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 716540005766 1 transmembrane helix predicted for EAM_1158 by TMHMM2.0 at aa 12-34 716540005767 Protein of unknown function (DUF523); Region: DUF523; pfam04463 716540005768 Uncharacterized conserved protein [Function unknown]; Region: COG3272 716540005769 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 716540005770 HMMPfam hit to PF04463, Protein of unknown function (DUF523), score 6.1e-46 716540005771 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 716540005772 HMMPfam hit to PF08349, Protein of unknown function (DUF1722), score 1.4e-62 716540005773 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 716540005774 DNA photolyase; Region: DNA_photolyase; pfam00875 716540005775 HMMPfam hit to PF00875, DNA photolyase, score 7.9e-61 716540005776 HMMPfam hit to PF03441, FAD binding domain of DNA photolyase, score 1.7e-143 716540005777 PS00394 DNA photolyases class 1 signature 1. 716540005778 PS00691 DNA photolyases class 1 signature 2. 716540005779 Uncharacterized conserved protein [Function unknown]; Region: COG0327 716540005780 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 716540005781 HMMPfam hit to PF01784, NIF3 (NGG1p interacting factor 3), score 1.4e-109 716540005782 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 716540005783 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 716540005784 HMMPfam hit to PF02682, Allophanate hydrolase subunit, score 5.8e-98 716540005785 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 716540005786 HMMPfam hit to PF02626, Allophanate hydrolase subunit, score 2.8e-136 716540005787 LamB/YcsF family protein; Provisional; Region: PRK05406 716540005788 HMMPfam hit to PF03746, LamB/YcsF family, score 3e-135 716540005789 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 716540005790 putative substrate binding pocket [chemical binding]; other site 716540005791 AC domain interface; other site 716540005792 catalytic triad [active] 716540005793 AB domain interface; other site 716540005794 interchain disulfide; other site 716540005795 HMMPfam hit to PF01470, Pyroglutamyl peptidase, score 1.5e-69 716540005796 PS01333 Pyrrolidone-carboxylate peptidase glutamic acid active site. 716540005797 endonuclease VIII; Provisional; Region: PRK10445 716540005798 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 716540005799 DNA binding site [nucleotide binding] 716540005800 catalytic residue [active] 716540005801 H2TH interface [polypeptide binding]; other site 716540005802 putative catalytic residues [active] 716540005803 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 716540005804 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 716540005805 HMMPfam hit to PF01149, Formamidopyrimidine-DNA glycosylase N-, score 1.6e-27 716540005806 HMMPfam hit to PF06831, Formamidopyrimidine-DNA glycosylase H2, score 2.5e-26 716540005807 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 716540005808 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 716540005809 dimer interface [polypeptide binding]; other site 716540005810 active site 716540005811 citrylCoA binding site [chemical binding]; other site 716540005812 NADH binding [chemical binding]; other site 716540005813 cationic pore residues; other site 716540005814 oxalacetate/citrate binding site [chemical binding]; other site 716540005815 coenzyme A binding site [chemical binding]; other site 716540005816 catalytic triad [active] 716540005817 HMMPfam hit to PF00285, Citrate synthase, score 4.5e-231 716540005818 PS00480 Citrate synthase signature. 716540005819 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 716540005820 Iron-sulfur protein interface; other site 716540005821 proximal quinone binding site [chemical binding]; other site 716540005822 SdhD (CybS) interface [polypeptide binding]; other site 716540005823 proximal heme binding site [chemical binding]; other site 716540005824 HMMPfam hit to PF01127, Succinate dehydrogenase cytochrome b subunit, score 2e-38 716540005825 PS01000 Succinate dehydrogenase cytochrome b subunit signature 1. 716540005826 3 transmembrane helices predicted for EAM_1168 by TMHMM2.0 at aa 28-50, 65-87 and 108-127 716540005827 PS01001 Succinate dehydrogenase cytochrome b subunit signature 2. 716540005828 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 716540005829 SdhC subunit interface [polypeptide binding]; other site 716540005830 proximal heme binding site [chemical binding]; other site 716540005831 cardiolipin binding site; other site 716540005832 Iron-sulfur protein interface; other site 716540005833 proximal quinone binding site [chemical binding]; other site 716540005834 3 transmembrane helices predicted for EAM_1169 by TMHMM2.0 at aa 17-39, 59-81 and 93-115 716540005835 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 716540005836 L-aspartate oxidase; Provisional; Region: PRK06175 716540005837 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 716540005838 HMMPfam hit to PF00890, FAD binding domain, score 2.7e-172 716540005839 PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site. 716540005840 HMMPfam hit to PF02910, Fumarate reductase/succinate dehydroge, score 1.6e-67 716540005841 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 716540005842 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 716540005843 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 716540005844 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 716540005845 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 716540005846 TPP-binding site [chemical binding]; other site 716540005847 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 716540005848 dimer interface [polypeptide binding]; other site 716540005849 PYR/PP interface [polypeptide binding]; other site 716540005850 TPP binding site [chemical binding]; other site 716540005851 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 716540005852 HMMPfam hit to PF00676, Dehydrogenase E1 component, score 3.1e-30 716540005853 HMMPfam hit to PF02779, Transketolase, pyridine binding domain, score 1.2e-73 716540005854 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 716540005855 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 716540005856 E3 interaction surface; other site 716540005857 lipoyl attachment site [posttranslational modification]; other site 716540005858 e3 binding domain; Region: E3_binding; pfam02817 716540005859 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 716540005860 HMMPfam hit to PF00364, Biotin-requiring enzyme, score 1.4e-22 716540005861 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 716540005862 HMMPfam hit to PF02817, e3 binding domain, score 1.1e-16 716540005863 HMMPfam hit to PF00198, 2-oxoacid dehydrogenases acyltransferas, score 7.3e-143 716540005864 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 716540005865 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 716540005866 CoA-ligase; Region: Ligase_CoA; pfam00549 716540005867 HMMPfam hit to PF08442, ATP-grasp domain, score 2.5e-133 716540005868 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540005869 HMMPfam hit to PF00549, CoA-ligase, score 5.5e-77 716540005870 PS01217 ATP-citrate lyase / succinyl-CoA ligases family signature 3. 716540005871 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 716540005872 CoA binding domain; Region: CoA_binding; pfam02629 716540005873 CoA-ligase; Region: Ligase_CoA; pfam00549 716540005874 HMMPfam hit to PF02629, CoA binding domain, score 3e-49 716540005875 HMMPfam hit to PF00549, CoA-ligase, score 2.5e-63 716540005876 PS01216 ATP-citrate lyase / succinyl-CoA ligases family signature 1. 716540005877 PS00399 ATP-citrate lyase / succinyl-CoA ligases family active site. 716540005878 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 716540005879 active site 716540005880 PS01328 4-hydroxybenzoyl-CoA thioesterase family active site. 716540005881 HMMPfam hit to PF03061, Thioesterase superfamily, score 1.9e-17 716540005882 colicin uptake protein TolQ; Provisional; Region: PRK10801 716540005883 Signal peptide predicted for EAM_1177 by SignalP 2.0 HMM (Signal peptide probability 0.736) with cleavage site probability 0.640 between residues 33 and 34 716540005884 3 transmembrane helices predicted for EAM_1177 by TMHMM2.0 at aa 15-37, 133-155 and 170-192 716540005885 HMMPfam hit to PF01618, MotA/TolQ/ExbB proton channel family, score 9.3e-63 716540005886 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 716540005887 colicin uptake protein TolR; Provisional; Region: PRK11024 716540005888 HMMPfam hit to PF02472, Biopolymer transport protein ExbD/TolR, score 5.7e-17 716540005889 1 transmembrane helix predicted for EAM_1178 by TMHMM2.0 at aa 17-39 716540005890 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 716540005891 TolA C-terminal; Region: TolA; pfam06519 716540005892 HMMPfam hit to PF06519, TolA protein, score 9.1e-144 716540005893 1 transmembrane helix predicted for EAM_1179 by TMHMM2.0 at aa 13-35 716540005894 PS00017 ATP/GTP-binding site motif A (P-loop). 716540005895 translocation protein TolB; Provisional; Region: tolB; PRK03629 716540005896 TolB amino-terminal domain; Region: TolB_N; pfam04052 716540005897 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 716540005898 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 716540005899 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 716540005900 Signal peptide predicted for EAM_1180 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.986 between residues 21 and 22 716540005901 HMMPfam hit to PF04052, TolB amino-terminal domain, score 1.1e-78 716540005902 HMMPfam hit to PF07676, WD40-like Beta Propeller Repeat, score 1e-06 716540005903 HMMPfam hit to PF07676, WD40-like Beta Propeller Repeat, score 9.3e-07 716540005904 HMMPfam hit to PF07676, WD40-like Beta Propeller Repeat, score 0.0054 716540005905 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 716540005906 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 716540005907 ligand binding site [chemical binding]; other site 716540005908 Signal peptide predicted for EAM_1181 by SignalP 2.0 HMM (Signal peptide probability 0.992) with cleavage site probability 0.669 between residues 26 and 27 716540005909 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540005910 HMMPfam hit to PF00691, OmpA family, score 1.1e-47 716540005911 PS01068 OmpA-like domain. 716540005912 tol-pal system protein YbgF; Provisional; Region: PRK10803 716540005913 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 716540005914 TPR motif; other site 716540005915 binding surface 716540005916 Signal peptide predicted for EAM_1182 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.743 between residues 26 and 27 716540005917 HMMPfam hit to PF00515, Tetratricopeptide repeat, score 0.21 716540005918 HMMPfam hit to PF00515, Tetratricopeptide repeat, score 0.0048 716540005919 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 716540005920 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 716540005921 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716540005922 AlkA N-terminal domain; Region: AlkA_N; pfam06029 716540005923 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 716540005924 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 716540005925 minor groove reading motif; other site 716540005926 helix-hairpin-helix signature motif; other site 716540005927 substrate binding pocket [chemical binding]; other site 716540005928 active site 716540005929 HMMPfam hit to PF00730, HhH-GPD superfamily base excision DNA, score 1e-05 716540005930 HMMPfam hit to PF06029, AlkA N-terminal domain, score 9.1e-43 716540005931 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix, score 5.8e-08 716540005932 PS00041 Bacterial regulatory proteins, araC family signature. 716540005933 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix, score 0.00015 716540005934 Predicted helix-turn-helix motif with score 1289.000, SD 3.58 at aa 101-122, sequence DSLEQIAAEFQLSLRQLRRIVK 716540005935 HMMPfam hit to PF02805, Metal binding domain of Ada, score 9.8e-37 716540005936 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 716540005937 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 716540005938 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 716540005939 DNA binding site [nucleotide binding] 716540005940 active site 716540005941 HMMPfam hit to PF02870, 6-O-methylguanine DNA methyltransfera, score 0.001 716540005942 HMMPfam hit to PF01035, 6-O-methylguanine DNA methyltransfera, score 5.3e-48 716540005943 Quinolinate synthetase A protein; Region: NadA; cl00420 716540005944 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 716540005945 HMMPfam hit to PF04973, Nicotinamide mononucleotide transport, score 2.9e-81 716540005946 7 transmembrane helices predicted for EAM_1188 by TMHMM2.0 at aa 20-42, 45-67, 71-88, 109-127, 159-176, 181-200 and 204-226 716540005947 zinc transporter ZitB; Provisional; Region: PRK03557 716540005948 HMMPfam hit to PF01545, Cation efflux family, score 1.7e-109 716540005949 PS00511 Corticotropin-releasing factor family signature. 716540005950 5 transmembrane helices predicted for EAM_1189 by TMHMM2.0 at aa 13-35, 45-64, 77-99, 114-136 and 149-171 716540005951 Signal peptide predicted for EAM_1189 by SignalP 2.0 HMM (Signal peptide probability 0.988) with cleavage site probability 0.584 between residues 31 and 32 716540005952 YbgS-like protein; Region: YbgS; pfam13985 716540005953 Signal peptide predicted for EAM_1190 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.892 between residues 23 and 24 716540005954 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 716540005955 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 716540005956 HMMPfam hit to PF00793, DAHP synthetase I family, score 6.9e-171 716540005957 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 716540005958 PS00422 Granins signature 1. 716540005959 RHS Repeat; Region: RHS_repeat; pfam05593 716540005960 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 716540005961 HMMPfam hit to PF05593, RHS Repeat, score 0.0052 716540005962 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 716540005963 catalytic core [active] 716540005964 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 716540005965 HMMPfam hit to PF00300, Phosphoglycerate mutase family, score 5.9e-45 716540005966 PS00175 Phosphoglycerate mutase family phosphohistidine signature. 716540005967 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 716540005968 active site 716540005969 catalytic residues [active] 716540005970 HMMPfam hit to PF01263, Aldose 1-epimerase, score 7.5e-115 716540005971 PS00545 Aldose 1-epimerase active site. 716540005972 galactokinase; Provisional; Region: PRK05101 716540005973 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 716540005974 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 716540005975 HMMPfam hit to PF08544, GHMP kinases C terminal, score 2e-12 716540005976 PS00017 ATP/GTP-binding site motif A (P-loop). 716540005977 HMMPfam hit to PF00288, GHMP kinases N terminal domain, score 1.2e-18 716540005978 PS00627 GHMP kinases ATP-binding domain. 716540005979 PS00106 Galactokinase signature. 716540005980 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 716540005981 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 716540005982 dimer interface [polypeptide binding]; other site 716540005983 active site 716540005984 HMMPfam hit to PF02744, Galactose-1-phosphate uridyl transfer, score 3.9e-95 716540005985 HMMPfam hit to PF01087, Galactose-1-phosphate uridyl transfer, score 9.1e-96 716540005986 PS00117 Galactose-1-phosphate uridyl transferase family 1 active site signature. 716540005987 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 716540005988 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716540005989 Walker A/P-loop; other site 716540005990 ATP binding site [chemical binding]; other site 716540005991 ABC transporter signature motif; other site 716540005992 Walker B; other site 716540005993 D-loop; other site 716540005994 H-loop/switch region; other site 716540005995 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716540005996 Walker A/P-loop; other site 716540005997 ATP binding site [chemical binding]; other site 716540005998 Q-loop/lid; other site 716540005999 ABC transporter signature motif; other site 716540006000 Walker B; other site 716540006001 D-loop; other site 716540006002 H-loop/switch region; other site 716540006003 HMMPfam hit to PF00005, ABC transporter, score 2e-47 716540006004 PS00017 ATP/GTP-binding site motif A (P-loop). 716540006005 HMMPfam hit to PF00005, ABC transporter, score 8.4e-30 716540006006 PS00017 ATP/GTP-binding site motif A (P-loop). 716540006007 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 716540006008 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 716540006009 molybdenum-pterin binding domain; Region: Mop; TIGR00638 716540006010 HMMPfam hit to PF03459, TOBE domain, score 1.1e-06 716540006011 HMMPfam hit to PF03459, TOBE domain, score 3.5e-14 716540006012 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix protei, score 4.1e-16 716540006013 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 716540006014 Signal peptide predicted for EAM_1200 by SignalP 2.0 HMM (Signal peptide probability 0.879) with cleavage site probability 0.800 between residues 20 and 21 716540006015 1 transmembrane helix predicted for EAM_1200 by TMHMM2.0 at aa 7-29 716540006016 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540006017 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 716540006018 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 716540006019 Signal peptide predicted for EAM_1202 by SignalP 2.0 HMM (Signal peptide probability 0.958) with cleavage site probability 0.881 between residues 24 and 25 716540006020 HMMPfam hit to PF01547, Bacterial extracellular solute-binding prot, score 0.002 716540006021 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 716540006022 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540006023 dimer interface [polypeptide binding]; other site 716540006024 conserved gate region; other site 716540006025 putative PBP binding loops; other site 716540006026 ABC-ATPase subunit interface; other site 716540006027 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.2e-23 716540006028 5 transmembrane helices predicted for EAM_1203 by TMHMM2.0 at aa 15-37, 49-71, 86-108, 136-158 and 197-219 716540006029 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 716540006030 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 716540006031 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716540006032 Walker A/P-loop; other site 716540006033 ATP binding site [chemical binding]; other site 716540006034 Q-loop/lid; other site 716540006035 ABC transporter signature motif; other site 716540006036 Walker B; other site 716540006037 D-loop; other site 716540006038 H-loop/switch region; other site 716540006039 TOBE domain; Region: TOBE; cl01440 716540006040 HMMPfam hit to PF00005, ABC transporter, score 1.3e-59 716540006041 PS00017 ATP/GTP-binding site motif A (P-loop). 716540006042 PS00211 ABC transporters family signature. 716540006043 HMMPfam hit to PF03459, TOBE domain, score 1.2e-12 716540006044 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 716540006045 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716540006046 active site 716540006047 motif I; other site 716540006048 motif II; other site 716540006049 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 716540006050 HMMPfam hit to PF05116, Sucrose-6F-phosphate phosphohydrolase, score 0.0033 716540006051 HMMPfam hit to PF08282, haloacid dehalogenase-like hydrolase, score 6.8e-68 716540006052 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 2.6e-11 716540006053 PS01229 Hypothetical cof family signature 2. 716540006054 PS01228 Hypothetical cof family signature 1. 716540006055 6-phosphogluconolactonase; Provisional; Region: PRK11028 716540006056 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 716540006057 substrate binding site [chemical binding]; other site 716540006058 HMMPfam hit to PF01161, Phosphatidylethanolamine-binding protein, score 3e-07 716540006059 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 716540006060 Prostaglandin dehydrogenases; Region: PGDH; cd05288 716540006061 NAD(P) binding site [chemical binding]; other site 716540006062 substrate binding site [chemical binding]; other site 716540006063 dimer interface [polypeptide binding]; other site 716540006064 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 5.9e-29 716540006065 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 716540006066 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 716540006067 inhibitor-cofactor binding pocket; inhibition site 716540006068 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716540006069 catalytic residue [active] 716540006070 HMMPfam hit to PF00202, Aminotransferase class-III, score 2.6e-149 716540006071 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 716540006072 biotin synthase; Provisional; Region: PRK15108 716540006073 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 716540006074 FeS/SAM binding site; other site 716540006075 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 716540006076 HMMPfam hit to PF04055, Radical SAM superfamily, score 4.2e-22 716540006077 HMMPfam hit to PF06968, Biotin and Thiamin Synthesis associated d, score 3.8e-53 716540006078 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 716540006079 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 716540006080 substrate-cofactor binding pocket; other site 716540006081 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716540006082 catalytic residue [active] 716540006083 HMMPfam hit to PF00202, Aminotransferase class-III, score 0.07 716540006084 HMMPfam hit to PF00155, Aminotransferase class I and II, score 5.2e-72 716540006085 HMMPfam hit to PF01212, Beta-eliminating lyase, score 0.00097 716540006086 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 716540006087 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 716540006088 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716540006089 S-adenosylmethionine binding site [chemical binding]; other site 716540006090 HMMPfam hit to PF01209, ubiE/COQ5 methyltransferase family, score 5e-06 716540006091 HMMPfam hit to PF08241, Methyltransferase domain, score 5.5e-35 716540006092 HMMPfam hit to PF08242, Methyltransferase domain, score 1.3e-14 716540006093 AAA domain; Region: AAA_26; pfam13500 716540006094 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 716540006095 HMMPfam hit to PF01656, CobQ/CobB/MinD/ParA nucleotide binding domai, score 3.2e-17 716540006096 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 716540006097 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 716540006098 Walker A/P-loop; other site 716540006099 ATP binding site [chemical binding]; other site 716540006100 Q-loop/lid; other site 716540006101 ABC transporter signature motif; other site 716540006102 Walker B; other site 716540006103 D-loop; other site 716540006104 H-loop/switch region; other site 716540006105 HMMPfam hit to PF00005, ABC transporter, score 6.2e-31 716540006106 PS00017 ATP/GTP-binding site motif A (P-loop). 716540006107 excinuclease ABC subunit B; Provisional; Region: PRK05298 716540006108 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 716540006109 ATP binding site [chemical binding]; other site 716540006110 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 716540006111 nucleotide binding region [chemical binding]; other site 716540006112 ATP-binding site [chemical binding]; other site 716540006113 Ultra-violet resistance protein B; Region: UvrB; pfam12344 716540006114 UvrB/uvrC motif; Region: UVR; pfam02151 716540006115 HMMPfam hit to PF04851, Type III restriction enzyme, res subunit, score 1.4e-05 716540006116 PS00017 ATP/GTP-binding site motif A (P-loop). 716540006117 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 4.7e-19 716540006118 HMMPfam hit to PF02151, UvrB/uvrC motif, score 1e-13 716540006119 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 716540006120 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 716540006121 phosphate binding site [ion binding]; other site 716540006122 putative substrate binding pocket [chemical binding]; other site 716540006123 dimer interface [polypeptide binding]; other site 716540006124 HMMPfam hit to PF01933, Uncharacterised protein family UPF0052, score 3.6e-112 716540006125 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 716540006126 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 716540006127 FeS/SAM binding site; other site 716540006128 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 716540006129 HMMPfam hit to PF04055, Radical SAM superfamily, score 5.6e-39 716540006130 PS01305 moaA / nifB / pqqE family signature. 716540006131 HMMPfam hit to PF06463, Molybdenum Cofactor Synthesis C, score 2.1e-47 716540006132 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 716540006133 MPT binding site; other site 716540006134 trimer interface [polypeptide binding]; other site 716540006135 HMMPfam hit to PF00994, molybdopterin binding domain, score 3.8e-33 716540006136 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 716540006137 trimer interface [polypeptide binding]; other site 716540006138 dimer interface [polypeptide binding]; other site 716540006139 putative active site [active] 716540006140 HMMPfam hit to PF01967, MoaC family, score 1.2e-90 716540006141 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 716540006142 MoaE interaction surface [polypeptide binding]; other site 716540006143 MoeB interaction surface [polypeptide binding]; other site 716540006144 thiocarboxylated glycine; other site 716540006145 HMMPfam hit to PF02597, ThiS family, score 3.1e-24 716540006146 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 716540006147 MoaE homodimer interface [polypeptide binding]; other site 716540006148 MoaD interaction [polypeptide binding]; other site 716540006149 active site residues [active] 716540006150 HMMPfam hit to PF02391, MoaE protein, score 9.8e-58 716540006151 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 716540006152 Signal peptide predicted for EAM_1223 by SignalP 2.0 HMM (Signal peptide probability 0.992) with cleavage site probability 0.603 between residues 26 and 27 716540006153 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540006154 HMMPfam hit to PF07759, Protein of unknown function (DUF1615), score 1.3e-216 716540006155 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 716540006156 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 716540006157 HMMPfam hit to PF01027, Uncharacterised protein family UPF0005, score 4.4e-49 716540006158 7 transmembrane helices predicted for EAM_1224 by TMHMM2.0 at aa 21-43, 58-80, 87-109, 114-133, 140-162, 167-186 and 211-233 716540006159 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 716540006160 4 transmembrane helices predicted for EAM_1225 by TMHMM2.0 at aa 13-32, 36-58, 78-95 and 99-118 716540006161 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 716540006162 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 716540006163 ATP binding site [chemical binding]; other site 716540006164 Mg++ binding site [ion binding]; other site 716540006165 motif III; other site 716540006166 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 716540006167 nucleotide binding region [chemical binding]; other site 716540006168 ATP-binding site [chemical binding]; other site 716540006169 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 4.7e-69 716540006170 PS00017 ATP/GTP-binding site motif A (P-loop). 716540006171 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 716540006172 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 8.1e-34 716540006173 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 716540006174 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 716540006175 FMN binding site [chemical binding]; other site 716540006176 active site 716540006177 catalytic residues [active] 716540006178 substrate binding site [chemical binding]; other site 716540006179 HMMPfam hit to PF01207, Dihydrouridine synthase (Dus), score 3.6e-125 716540006180 PS01136 Uncharacterized protein family UPF0034 signature. 716540006181 L,D-transpeptidase; Provisional; Region: PRK10260 716540006182 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 716540006183 HMMPfam hit to PF03734, ErfK/YbiS/YcfS/YnhG, score 7.3e-64 716540006184 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 716540006185 1 transmembrane helix predicted for EAM_1228 by TMHMM2.0 at aa 7-29 716540006186 Signal peptide predicted for EAM_1228 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 24 and 25 716540006187 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 716540006188 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 716540006189 HMMPfam hit to PF00723, Glycosyl hydrolases family, score 6.2e-85 716540006190 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 716540006191 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 716540006192 5 transmembrane helices predicted for EAM_1230 by TMHMM2.0 at aa 13-35, 45-67, 95-117, 130-152 and 165-182 716540006193 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 716540006194 HMMPfam hit to PF06930, Protein of unknown function (DUF1282), score 6.6e-114 716540006195 5 transmembrane helices predicted for EAM_1231 by TMHMM2.0 at aa 33-55, 65-87, 108-130, 135-157 and 170-192 716540006196 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 716540006197 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 716540006198 Signal peptide predicted for EAM_1232 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.403 between residues 29 and 30 716540006199 HMMPfam hit to PF00768, D-alanyl-D-alanine carboxypeptidase, score 2.2e-101 716540006200 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 716540006201 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 716540006202 Mechanosensitive ion channel; Region: MS_channel; pfam00924 716540006203 Signal peptide predicted for EAM_1233 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 25 and 26 716540006204 10 transmembrane helices predicted for EAM_1233 by TMHMM2.0 at aa 214-236, 257-279, 299-316, 328-350, 365-387, 408-430, 434-456, 492-514, 543-565 and 585-607 716540006205 HMMPfam hit to PF00924, Mechanosensitive ion channel, score 6.7e-47 716540006206 D-lactate dehydrogenase; Provisional; Region: PRK11183 716540006207 FAD binding domain; Region: FAD_binding_4; pfam01565 716540006208 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 716540006209 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 716540006210 HMMPfam hit to PF01565, FAD binding domain, score 1e-09 716540006211 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 716540006212 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 716540006213 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 716540006214 Signal peptide predicted for EAM_1236 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 20 and 21 716540006215 HMMPfam hit to PF00933, Glycosyl hydrolase family 3 N termina, score 1.4e-101 716540006216 HMMPfam hit to PF01915, Glycosyl hydrolase family 3 C termina, score 5.3e-96 716540006217 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 716540006218 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 716540006219 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 716540006220 active site 716540006221 metal binding site [ion binding]; metal-binding site 716540006222 nudix motif; other site 716540006223 HMMPfam hit to PF00293, NUDIX domain, score 1.6e-19 716540006224 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 716540006225 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 716540006226 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 716540006227 hypothetical protein; Provisional; Region: PRK13681 716540006228 1 transmembrane helix predicted for EAM_1240 by TMHMM2.0 at aa 10-32 716540006229 Signal peptide predicted for EAM_1240 by SignalP 2.0 HMM (Signal peptide probability 0.960) with cleavage site probability 0.749 between residues 25 and 26 716540006230 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 716540006231 Signal peptide predicted for EAM_1241 by SignalP 2.0 HMM (Signal peptide probability 0.979) with cleavage site probability 0.515 between residues 22 and 23 716540006232 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540006233 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 716540006234 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716540006235 S-adenosylmethionine binding site [chemical binding]; other site 716540006236 HMMPfam hit to PF02353, Cyclopropane-fatty-acyl-phospholipid, score 1.4e-102 716540006237 HMMPfam hit to PF08241, Methyltransferase domain, score 5.3e-17 716540006238 HMMPfam hit to PF08242, Methyltransferase domain, score 1.8e-10 716540006239 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 716540006240 HMMPfam hit to PF07103, Protein of unknown function (DUF1365), score 2.6e-112 716540006241 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 716540006242 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 716540006243 HMMPfam hit to PF01593, Flavin containing amine oxidoreductase, score 0.00087 716540006244 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 0.00084 716540006245 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540006246 short chain dehydrogenase; Provisional; Region: PRK06101 716540006247 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 716540006248 NAD(P) binding site [chemical binding]; other site 716540006249 active site 716540006250 HMMPfam hit to PF00106, short chain dehydrogenase, score 7.4e-21 716540006251 PS00061 Short-chain dehydrogenases/reductases family signature. 716540006252 Signal peptide predicted for EAM_1245 by SignalP 2.0 HMM (Signal peptide probability 0.861) with cleavage site probability 0.667 between residues 22 and 23 716540006253 SnoaL-like domain; Region: SnoaL_2; pfam12680 716540006254 transcriptional regulator MirA; Provisional; Region: PRK15043 716540006255 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 716540006256 DNA binding residues [nucleotide binding] 716540006257 HMMPfam hit to PF00376, MerR family regulatory protein, score 2.3e-11 716540006258 PS00552 Bacterial regulatory proteins, merR family signature. 716540006259 Predicted helix-turn-helix motif with score 1997.000, SD 5.99 at aa 4-25, sequence YSIGDVAEKCGINPVTLRAWQR 716540006260 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716540006261 Coenzyme A binding pocket [chemical binding]; other site 716540006262 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1.4e-09 716540006263 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 716540006264 DEAD_2; Region: DEAD_2; pfam06733 716540006265 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 716540006266 PS00017 ATP/GTP-binding site motif A (P-loop). 716540006267 glycosyl transferase family protein; Provisional; Region: PRK08136 716540006268 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 716540006269 HMMPfam hit to PF02885, Glycosyl transferase family, helical, score 9.5e-18 716540006270 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 716540006271 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 716540006272 metal binding site [ion binding]; metal-binding site 716540006273 putative dimer interface [polypeptide binding]; other site 716540006274 HMMPfam hit to PF01546, Peptidase family M20/M25/M40, score 2.4e-59 716540006275 HMMPfam hit to PF07687, Peptidase dimerisation domain, score 3.4e-09 716540006276 urocanate hydratase; Provisional; Region: PRK05414 716540006277 HMMPfam hit to PF01175, Urocanase, score 0 716540006278 PS01233 Urocanase active site. 716540006279 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 716540006280 active sites [active] 716540006281 tetramer interface [polypeptide binding]; other site 716540006282 PS00139 Eukaryotic thiol (cysteine) proteases cysteine active site. 716540006283 HMMPfam hit to PF00221, Phenylalanine and histidine ammonia-lyase, score 2e-207 716540006284 PS00488 Phenylalanine and histidine ammonia-lyases signature. 716540006285 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 716540006286 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 716540006287 DNA-binding site [nucleotide binding]; DNA binding site 716540006288 UTRA domain; Region: UTRA; pfam07702 716540006289 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR family, score 1.1e-25 716540006290 PS00043 Bacterial regulatory proteins, gntR family signature. 716540006291 Predicted helix-turn-helix motif with score 1467.000, SD 4.18 at aa 45-66, sequence PSESELVNELGVSRMTINRALR 716540006292 HMMPfam hit to PF07702, UTRA domain, score 1.1e-41 716540006293 HutD; Region: HutD; cl01532 716540006294 HMMPfam hit to PF05962, Bacterial protein of unknown function (DUF88, score 4.8e-42 716540006295 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 716540006296 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 716540006297 active site 716540006298 HMMPfam hit to PF01979, Amidohydrolase family, score 3.1e-13 716540006299 imidazolonepropionase; Validated; Region: PRK09356 716540006300 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 716540006301 active site 716540006302 HMMPfam hit to PF01979, Amidohydrolase family, score 7.8e-07 716540006303 HMMPfam hit to PF07969, Amidohydrolase family, score 5.6e-07 716540006304 N-formylglutamate amidohydrolase; Region: FGase; cl01522 716540006305 HMMPfam hit to PF05013, N-formylglutamate amidohydrolase, score 6.1e-93 716540006306 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 716540006307 HMMPfam hit to PF06941, 5' nucleotidase, deoxy (Pyrimidine), cytosol, score 1.1e-05 716540006308 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 716540006309 Aspartyl protease; Region: Asp_protease_2; pfam13650 716540006310 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 716540006311 inhibitor binding site; inhibition site 716540006312 catalytic motif [active] 716540006313 Catalytic residue [active] 716540006314 Active site flap [active] 716540006315 PS00141 Eukaryotic and viral aspartyl proteases active site. 716540006316 Signal peptide predicted for EAM_1263 by SignalP 2.0 HMM (Signal peptide probability 0.764) with cleavage site probability 0.375 between residues 26 and 27 716540006317 1 transmembrane helix predicted for EAM_1263 by TMHMM2.0 at aa 7-26 716540006318 HMMPfam hit to PF04055, Radical SAM superfamily, score 0.012 716540006319 PS01305 moaA / nifB / pqqE family signature. 716540006320 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 716540006321 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 716540006322 HMMPfam hit to PF05971, Protein of unknown function (DUF890), score 1.7e-182 716540006323 PS00237 G-protein coupled receptors signature. 716540006324 putative mechanosensitive channel protein; Provisional; Region: PRK11465 716540006325 Mechanosensitive ion channel; Region: MS_channel; pfam00924 716540006326 HMMPfam hit to PF00924, Mechanosensitive ion channel, score 2.3e-55 716540006327 11 transmembrane helices predicted for EAM_1266 by TMHMM2.0 at aa 11-33, 151-173, 194-216, 231-253, 274-296, 306-328, 348-370, 385-407, 442-464, 479-501 and 522-544 716540006328 Signal peptide predicted for EAM_1266 by SignalP 2.0 HMM (Signal peptide probability 0.965) with cleavage site probability 0.373 between residues 32 and 33 716540006329 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 716540006330 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 716540006331 Walker A/P-loop; other site 716540006332 ATP binding site [chemical binding]; other site 716540006333 Q-loop/lid; other site 716540006334 ABC transporter signature motif; other site 716540006335 Walker B; other site 716540006336 D-loop; other site 716540006337 H-loop/switch region; other site 716540006338 HMMPfam hit to PF00005, ABC transporter, score 1.2e-67 716540006339 PS00211 ABC transporters family signature. 716540006340 PS00017 ATP/GTP-binding site motif A (P-loop). 716540006341 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 716540006342 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540006343 dimer interface [polypeptide binding]; other site 716540006344 conserved gate region; other site 716540006345 putative PBP binding loops; other site 716540006346 ABC-ATPase subunit interface; other site 716540006347 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 5.9e-36 716540006348 5 transmembrane helices predicted for EAM_1269 by TMHMM2.0 at aa 20-42, 55-77, 92-114, 155-177 and 187-209 716540006349 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 716540006350 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 716540006351 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 716540006352 substrate binding pocket [chemical binding]; other site 716540006353 membrane-bound complex binding site; other site 716540006354 hinge residues; other site 716540006355 HMMPfam hit to PF00497, Bacterial extracellular solute-binding prot, score 2.6e-88 716540006356 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 716540006357 Signal peptide predicted for EAM_1270 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.921 between residues 23 and 24 716540006358 hypothetical protein; Provisional; Region: PRK11019 716540006359 HMMPfam hit to PF01258, Prokaryotic dksA/traR C4-type zinc finge, score 5.5e-21 716540006360 PS01102 Prokaryotic dksA/traR C4-type zinc finger. 716540006361 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 716540006362 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 716540006363 dimerization interface [polypeptide binding]; other site 716540006364 DPS ferroxidase diiron center [ion binding]; other site 716540006365 ion pore; other site 716540006366 HMMPfam hit to PF00210, Ferritin-like domain, score 4.5e-20 716540006367 PS00818 Dps protein family signature 1. 716540006368 threonine and homoserine efflux system; Provisional; Region: PRK10532 716540006369 EamA-like transporter family; Region: EamA; pfam00892 716540006370 10 transmembrane helices predicted for EAM_1273 by TMHMM2.0 at aa 9-31, 37-59, 72-90, 94-113, 120-138, 148-167, 179-198, 203-225, 238-257 and 262-281 716540006371 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 1.3e-18 716540006372 Signal peptide predicted for EAM_1273 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.981 between residues 31 and 32 716540006373 outer membrane protein X; Provisional; Region: ompX; PRK09408 716540006374 HMMPfam hit to PF06316, Enterobacterial Ail/Lom protein, score 3.9e-14 716540006375 Signal peptide predicted for EAM_1274 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 23 and 24 716540006376 PS00694 Enterobacterial virulence outer membrane protein signature 1. 716540006377 manganese transport regulator MntR; Provisional; Region: PRK11050 716540006378 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 716540006379 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 716540006380 HMMPfam hit to PF01325, Iron dependent repressor, N-terminal D, score 2.9e-08 716540006381 HMMPfam hit to PF01047, MarR family, score 0.0017 716540006382 Predicted helix-turn-helix motif with score 1524.000, SD 4.38 at aa 52-73, sequence ARQVDMAARLGVSQPTVAKMLK 716540006383 HMMPfam hit to PF02742, Iron dependent repressor, metal bindin, score 6.6e-05 716540006384 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 716540006385 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 716540006386 HlyD family secretion protein; Region: HlyD_3; pfam13437 716540006387 1 transmembrane helix predicted for EAM_1276 by TMHMM2.0 at aa 39-61 716540006388 HMMPfam hit to PF00529, HlyD family secretion protein, score 5.5e-37 716540006389 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 716540006390 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540006391 putative substrate translocation pore; other site 716540006392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540006393 13 transmembrane helices predicted for EAM_1277 by TMHMM2.0 at aa 13-35, 55-77, 82-104, 140-162, 171-190, 205-224, 237-259, 274-296, 308-330, 340-359, 372-394, 404-426 and 486-508 716540006394 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.1e-53 716540006395 PS00092 N-6 Adenine-specific DNA methylases signature. 716540006396 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 716540006397 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540006398 HMMPfam hit to PF02321, Outer membrane efflux protein, score 1.5e-20 716540006399 HMMPfam hit to PF02321, Outer membrane efflux protein, score 2.5e-40 716540006400 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 716540006401 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 716540006402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540006403 putative substrate translocation pore; other site 716540006404 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540006405 HMMPfam hit to PF00083, Sugar (and other) transporter, score 5.5e-116 716540006406 12 transmembrane helices predicted for EAM_1281 by TMHMM2.0 at aa 28-50, 65-87, 94-113, 118-140, 152-174, 184-206, 267-289, 304-326, 335-357, 372-394, 406-428 and 432-454 716540006407 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.4e-37 716540006408 PS00217 Sugar transport proteins signature 2. 716540006409 PS00017 ATP/GTP-binding site motif A (P-loop). 716540006410 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 716540006411 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 716540006412 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716540006413 Walker A/P-loop; other site 716540006414 ATP binding site [chemical binding]; other site 716540006415 ABC transporter signature motif; other site 716540006416 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 716540006417 Walker B; other site 716540006418 ABC transporter; Region: ABC_tran_2; pfam12848 716540006419 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 716540006420 HMMPfam hit to PF00005, ABC transporter, score 3e-41 716540006421 PS00017 ATP/GTP-binding site motif A (P-loop). 716540006422 HMMPfam hit to PF00005, ABC transporter, score 1.3e-49 716540006423 PS00017 ATP/GTP-binding site motif A (P-loop). 716540006424 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 716540006425 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 716540006426 ATP binding site [chemical binding]; other site 716540006427 substrate interface [chemical binding]; other site 716540006428 HMMPfam hit to PF05237, MoeZ/MoeB domain, score 2e-37 716540006429 HMMPfam hit to PF00899, ThiF family, score 1.9e-58 716540006430 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 716540006431 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 716540006432 dimer interface [polypeptide binding]; other site 716540006433 putative functional site; other site 716540006434 putative MPT binding site; other site 716540006435 HMMPfam hit to PF03454, MoeA C-terminal region (domain IV), score 5.4e-21 716540006436 HMMPfam hit to PF00994, molybdopterin binding domain, score 2.5e-51 716540006437 PS01079 Molybdenum cofactor biosynthesis proteins signature 2. 716540006438 HMMPfam hit to PF03453, MoeA N-terminal region (domain I and II, score 1.5e-71 716540006439 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 716540006440 catalytic nucleophile [active] 716540006441 HMMPfam hit to PF01112, Asparaginase, score 5.3e-124 716540006442 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 716540006443 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 716540006444 Walker A/P-loop; other site 716540006445 ATP binding site [chemical binding]; other site 716540006446 Q-loop/lid; other site 716540006447 ABC transporter signature motif; other site 716540006448 Walker B; other site 716540006449 D-loop; other site 716540006450 H-loop/switch region; other site 716540006451 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 716540006452 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 716540006453 Walker A/P-loop; other site 716540006454 ATP binding site [chemical binding]; other site 716540006455 Q-loop/lid; other site 716540006456 ABC transporter signature motif; other site 716540006457 Walker B; other site 716540006458 D-loop; other site 716540006459 H-loop/switch region; other site 716540006460 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 716540006461 HMMPfam hit to PF00005, ABC transporter, score 2.4e-57 716540006462 PS00017 ATP/GTP-binding site motif A (P-loop). 716540006463 PS00211 ABC transporters family signature. 716540006464 HMMPfam hit to PF08352, Oligopeptide/dipeptide transporter, C-termi, score 2.2e-06 716540006465 HMMPfam hit to PF00005, ABC transporter, score 2.8e-63 716540006466 PS00017 ATP/GTP-binding site motif A (P-loop). 716540006467 PS00211 ABC transporters family signature. 716540006468 HMMPfam hit to PF08352, Oligopeptide/dipeptide transporter, C-termi, score 1.3e-08 716540006469 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 716540006470 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 716540006471 Signal peptide predicted for EAM_1287 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.869 between residues 26 and 27 716540006472 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540006473 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 1.6e-85 716540006474 PS01040 Bacterial extracellular solute-binding proteins, family 5 signature. 716540006475 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 716540006476 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540006477 dimer interface [polypeptide binding]; other site 716540006478 conserved gate region; other site 716540006479 putative PBP binding loops; other site 716540006480 ABC-ATPase subunit interface; other site 716540006481 Signal peptide predicted for EAM_1288 by SignalP 2.0 HMM (Signal peptide probability 0.862) with cleavage site probability 0.474 between residues 29 and 30 716540006482 6 transmembrane helices predicted for EAM_1288 by TMHMM2.0 at aa 9-31, 101-123, 135-157, 172-191, 227-249 and 278-300 716540006483 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 4.5e-51 716540006484 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 716540006485 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 716540006486 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540006487 dimer interface [polypeptide binding]; other site 716540006488 conserved gate region; other site 716540006489 putative PBP binding loops; other site 716540006490 ABC-ATPase subunit interface; other site 716540006491 Signal peptide predicted for EAM_1289 by SignalP 2.0 HMM (Signal peptide probability 0.889) with cleavage site probability 0.319 between residues 55 and 56 716540006492 6 transmembrane helices predicted for EAM_1289 by TMHMM2.0 at aa 39-61, 105-127, 134-156, 161-183, 223-245 and 265-287 716540006493 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 2.2e-46 716540006494 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 716540006495 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 716540006496 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 716540006497 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 716540006498 Signal peptide predicted for EAM_1293 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.560 between residues 30 and 31 716540006499 1 transmembrane helix predicted for EAM_1293 by TMHMM2.0 at aa 7-26 716540006500 HMMPfam hit to PF00768, D-alanyl-D-alanine carboxypeptidase, score 2.2e-131 716540006501 HMMPfam hit to PF07943, Penicillin-binding protein 5, C-termina, score 4e-39 716540006502 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 716540006503 serine transporter; Region: stp; TIGR00814 716540006504 11 transmembrane helices predicted for EAM_1294 by TMHMM2.0 at aa 26-48, 52-74, 103-122, 137-156, 169-191, 211-233, 254-273, 301-323, 347-364, 369-391 and 404-426 716540006505 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 716540006506 active site 716540006507 6 transmembrane helices predicted for EAM_1295 by TMHMM2.0 at aa 21-43, 79-101, 108-130, 162-181, 188-210 and 220-239 716540006508 putative transporter; Provisional; Region: PRK04972 716540006509 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 716540006510 TrkA-C domain; Region: TrkA_C; pfam02080 716540006511 TrkA-C domain; Region: TrkA_C; pfam02080 716540006512 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 716540006513 9 transmembrane helices predicted for EAM_1296 by TMHMM2.0 at aa 13-35, 64-86, 93-115, 159-181, 383-405, 409-426, 447-464, 474-496 and 535-557 716540006514 HMMPfam hit to PF06826, Predicted Permease Membrane Region, score 1.6e-63 716540006515 HMMPfam hit to PF02080, TrkA-C domain, score 7e-12 716540006516 HMMPfam hit to PF02080, TrkA-C domain, score 1e-10 716540006517 HMMPfam hit to PF06826, Predicted Permease Membrane Region, score 9.4e-62 716540006518 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 716540006519 GSH binding site [chemical binding]; other site 716540006520 catalytic residues [active] 716540006521 HMMPfam hit to PF00462, Glutaredoxin, score 3e-12 716540006522 PS00195 Glutaredoxin active site. 716540006523 hypothetical protein; Provisional; Region: PRK10591 716540006524 2 transmembrane helices predicted for EAM_1298 by TMHMM2.0 at aa 7-29 and 44-63 716540006525 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 716540006526 dimer interface [polypeptide binding]; other site 716540006527 FMN binding site [chemical binding]; other site 716540006528 NADPH bind site [chemical binding]; other site 716540006529 HMMPfam hit to PF00881, Nitroreductase family, score 6.1e-38 716540006530 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 716540006531 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 716540006532 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 716540006533 Signal peptide predicted for EAM_1301 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.748 between residues 26 and 27 716540006534 HMMPfam hit to PF01547, Bacterial extracellular solute-binding prot, score 2.6e-11 716540006535 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 716540006536 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716540006537 Walker A/P-loop; other site 716540006538 ATP binding site [chemical binding]; other site 716540006539 Q-loop/lid; other site 716540006540 ABC transporter signature motif; other site 716540006541 Walker B; other site 716540006542 D-loop; other site 716540006543 H-loop/switch region; other site 716540006544 TOBE domain; Region: TOBE_2; pfam08402 716540006545 HMMPfam hit to PF00005, ABC transporter, score 5.9e-66 716540006546 PS00017 ATP/GTP-binding site motif A (P-loop). 716540006547 PS00211 ABC transporters family signature. 716540006548 HMMPfam hit to PF08402, TOBE domain, score 8.9e-24 716540006549 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540006550 dimer interface [polypeptide binding]; other site 716540006551 conserved gate region; other site 716540006552 putative PBP binding loops; other site 716540006553 ABC-ATPase subunit interface; other site 716540006554 6 transmembrane helices predicted for EAM_1303 by TMHMM2.0 at aa 34-55, 103-125, 138-160, 188-210, 231-253 and 287-309 716540006555 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 9.1e-26 716540006556 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 716540006557 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 716540006558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540006559 dimer interface [polypeptide binding]; other site 716540006560 conserved gate region; other site 716540006561 putative PBP binding loops; other site 716540006562 ABC-ATPase subunit interface; other site 716540006563 Signal peptide predicted for EAM_1304 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.600 between residues 41 and 42 716540006564 6 transmembrane helices predicted for EAM_1304 by TMHMM2.0 at aa 13-35, 68-90, 103-125, 140-162, 183-205 and 241-263 716540006565 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 0.0013 716540006566 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 716540006567 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 716540006568 Signal peptide predicted for EAM_1306 by SignalP 2.0 HMM (Signal peptide probability 0.894) with cleavage site probability 0.506 between residues 42 and 43 716540006569 4 transmembrane helices predicted for EAM_1306 by TMHMM2.0 at aa 21-43, 58-80, 93-115 and 130-152 716540006570 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 716540006571 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 716540006572 substrate binding pocket [chemical binding]; other site 716540006573 membrane-bound complex binding site; other site 716540006574 hinge residues; other site 716540006575 HMMPfam hit to PF00497, Bacterial extracellular solute-binding prot, score 1.4e-85 716540006576 PS00213 Lipocalin signature. 716540006577 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 716540006578 Signal peptide predicted for EAM_1307 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.784 between residues 19 and 20 716540006579 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540006580 dimer interface [polypeptide binding]; other site 716540006581 conserved gate region; other site 716540006582 putative PBP binding loops; other site 716540006583 ABC-ATPase subunit interface; other site 716540006584 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 2.1e-16 716540006585 5 transmembrane helices predicted for EAM_1308 by TMHMM2.0 at aa 15-37, 50-72, 92-114, 155-174 and 189-211 716540006586 Signal peptide predicted for EAM_1308 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.891 between residues 38 and 39 716540006587 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 716540006588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540006589 dimer interface [polypeptide binding]; other site 716540006590 conserved gate region; other site 716540006591 putative PBP binding loops; other site 716540006592 ABC-ATPase subunit interface; other site 716540006593 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.6e-15 716540006594 4 transmembrane helices predicted for EAM_1309 by TMHMM2.0 at aa 10-32, 53-75, 101-118 and 201-223 716540006595 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 716540006596 Signal peptide predicted for EAM_1309 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.925 between residues 33 and 34 716540006597 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 716540006598 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 716540006599 substrate binding pocket [chemical binding]; other site 716540006600 membrane-bound complex binding site; other site 716540006601 hinge residues; other site 716540006602 HMMPfam hit to PF00497, Bacterial extracellular solute-binding prot, score 1.9e-96 716540006603 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 716540006604 Signal peptide predicted for EAM_1310 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.899 between residues 24 and 25 716540006605 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 716540006606 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716540006607 Walker A/P-loop; other site 716540006608 ATP binding site [chemical binding]; other site 716540006609 Q-loop/lid; other site 716540006610 ABC transporter signature motif; other site 716540006611 Walker B; other site 716540006612 D-loop; other site 716540006613 H-loop/switch region; other site 716540006614 HMMPfam hit to PF00005, ABC transporter, score 9.8e-72 716540006615 PS00211 ABC transporters family signature. 716540006616 PS00017 ATP/GTP-binding site motif A (P-loop). 716540006617 putative lipoprotein; Provisional; Region: PRK10533 716540006618 Signal peptide predicted for EAM_1312 by SignalP 2.0 HMM (Signal peptide probability 0.984) with cleavage site probability 0.406 between residues 21 and 22 716540006619 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540006620 hypothetical protein; Provisional; Region: PRK02877 716540006621 HMMPfam hit to PF01906, Domain of unknown function DUF74, score 4.2e-62 716540006622 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 716540006623 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 716540006624 amidase catalytic site [active] 716540006625 Zn binding residues [ion binding]; other site 716540006626 substrate binding site [chemical binding]; other site 716540006627 HMMPfam hit to PF01510, N-acetylmuramoyl-L-alanine amidase, score 1.1e-29 716540006628 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 716540006629 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 716540006630 tetramer interface [polypeptide binding]; other site 716540006631 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716540006632 catalytic residue [active] 716540006633 HMMPfam hit to PF01212, Beta-eliminating lyase, score 1.4e-143 716540006634 pyruvate dehydrogenase; Provisional; Region: PRK09124 716540006635 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 716540006636 PYR/PP interface [polypeptide binding]; other site 716540006637 dimer interface [polypeptide binding]; other site 716540006638 tetramer interface [polypeptide binding]; other site 716540006639 TPP binding site [chemical binding]; other site 716540006640 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 716540006641 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 716540006642 TPP-binding site [chemical binding]; other site 716540006643 HMMPfam hit to PF02775, Thiamine pyrophosphate enzyme, C-termina, score 2.5e-57 716540006644 PS00187 Thiamine pyrophosphate enzymes signature. 716540006645 HMMPfam hit to PF00205, Thiamine pyrophosphate enzyme, central d, score 3e-47 716540006646 HMMPfam hit to PF02776, Thiamine pyrophosphate enzyme, N-termina, score 8e-71 716540006647 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 716540006648 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 716540006649 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 716540006650 putative active site [active] 716540006651 putative metal-binding site [ion binding]; other site 716540006652 PS00017 ATP/GTP-binding site motif A (P-loop). 716540006653 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 716540006654 DNA-binding site [nucleotide binding]; DNA binding site 716540006655 RNA-binding motif; other site 716540006656 HMMPfam hit to PF00313, 'Cold-shock' DNA-binding domain, score 3e-39 716540006657 PS00352 'Cold-shock' DNA-binding domain signature. 716540006658 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 716540006659 HMMPfam hit to PF02617, ATP-dependent Clp protease adaptor protein C, score 3.5e-48 716540006660 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 716540006661 Clp amino terminal domain; Region: Clp_N; pfam02861 716540006662 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716540006663 Walker A motif; other site 716540006664 ATP binding site [chemical binding]; other site 716540006665 Walker B motif; other site 716540006666 arginine finger; other site 716540006667 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716540006668 Walker A motif; other site 716540006669 ATP binding site [chemical binding]; other site 716540006670 Walker B motif; other site 716540006671 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 716540006672 HMMPfam hit to PF02861, Clp amino terminal domain, score 1.8e-16 716540006673 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 2.7e-18 716540006674 PS00017 ATP/GTP-binding site motif A (P-loop). 716540006675 PS00870 Chaperonins clpA/B signature 1. 716540006676 HMMPfam hit to PF07724, ATPase family associated with various cellul, score 1e-89 716540006677 HMMPfam hit to PF07728, ATPase family associated with various cellul, score 1.6e-05 716540006678 PS00017 ATP/GTP-binding site motif A (P-loop). 716540006679 PS00871 Chaperonins clpA/B signature 2. 716540006680 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 716540006681 rRNA binding site [nucleotide binding]; other site 716540006682 predicted 30S ribosome binding site; other site 716540006683 HMMPfam hit to PF00575, S1 RNA binding domain, score 1.6e-10 716540006684 HMMPfam hit to PF01176, Translation initiation factor 1A / IF-1, score 1.5e-36 716540006685 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 716540006686 HMMPfam hit to PF03588, Leucyl/phenylalanyl-tRNA protein transf, score 6.9e-105 716540006687 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 716540006688 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716540006689 Walker A/P-loop; other site 716540006690 ATP binding site [chemical binding]; other site 716540006691 Q-loop/lid; other site 716540006692 ABC transporter signature motif; other site 716540006693 Walker B; other site 716540006694 D-loop; other site 716540006695 H-loop/switch region; other site 716540006696 HMMPfam hit to PF00005, ABC transporter, score 2.1e-61 716540006697 PS00211 ABC transporters family signature. 716540006698 PS00017 ATP/GTP-binding site motif A (P-loop). 716540006699 5 transmembrane helices predicted for EAM_1325 by TMHMM2.0 at aa 21-43, 133-155, 162-184, 250-272 and 279-301 716540006700 Signal peptide predicted for EAM_1325 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.838 between residues 49 and 50 716540006701 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 716540006702 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 716540006703 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 716540006704 Walker A/P-loop; other site 716540006705 ATP binding site [chemical binding]; other site 716540006706 Q-loop/lid; other site 716540006707 ABC transporter signature motif; other site 716540006708 Walker B; other site 716540006709 D-loop; other site 716540006710 H-loop/switch region; other site 716540006711 HMMPfam hit to PF00005, ABC transporter, score 5.1e-61 716540006712 PS00211 ABC transporters family signature. 716540006713 PS00017 ATP/GTP-binding site motif A (P-loop). 716540006714 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 1.8e-33 716540006715 6 transmembrane helices predicted for EAM_1326 by TMHMM2.0 at aa 23-45, 60-82, 137-159, 163-185, 246-268 and 278-297 716540006716 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 716540006717 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540006718 Signal peptide predicted for EAM_1326 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.235 between residues 42 and 43 716540006719 thioredoxin reductase; Provisional; Region: PRK10262 716540006720 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 716540006721 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 716540006722 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidoreduc, score 2.2e-52 716540006723 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreduc, score 2.2e-24 716540006724 PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site. 716540006725 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 716540006726 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 716540006727 putative DNA binding site [nucleotide binding]; other site 716540006728 putative Zn2+ binding site [ion binding]; other site 716540006729 AsnC family; Region: AsnC_trans_reg; pfam01037 716540006730 PS00519 Bacterial regulatory proteins, asnC family signature. 716540006731 HMMPfam hit to PF01037, AsnC family, score 2.9e-29 716540006732 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 716540006733 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 716540006734 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 716540006735 5 transmembrane helices predicted for EAM_1329 by TMHMM2.0 at aa 22-44, 75-97, 110-132, 137-159 and 164-186 716540006736 HMMPfam hit to PF01580, FtsK/SpoIIIE family, score 2.2e-99 716540006737 PS00017 ATP/GTP-binding site motif A (P-loop). 716540006738 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 716540006739 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 716540006740 Signal peptide predicted for EAM_1330 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.978 between residues 21 and 22 716540006741 HMMPfam hit to PF03548, Outer membrane lipoprotein carrier protein L, score 1.5e-74 716540006742 recombination factor protein RarA; Reviewed; Region: PRK13342 716540006743 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716540006744 Walker A motif; other site 716540006745 ATP binding site [chemical binding]; other site 716540006746 Walker B motif; other site 716540006747 arginine finger; other site 716540006748 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 716540006749 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 2.3e-19 716540006750 PS00017 ATP/GTP-binding site motif A (P-loop). 716540006751 seryl-tRNA synthetase; Provisional; Region: PRK05431 716540006752 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 716540006753 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 716540006754 dimer interface [polypeptide binding]; other site 716540006755 active site 716540006756 motif 1; other site 716540006757 motif 2; other site 716540006758 motif 3; other site 716540006759 HMMPfam hit to PF02403, Seryl-tRNA synthetase N-terminal domain, score 4.3e-46 716540006760 HMMPfam hit to PF00587, tRNA synthetase class II core domain (G,, score 6.7e-69 716540006761 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 716540006762 putative MFS family transporter protein; Provisional; Region: PRK03633 716540006763 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540006764 putative substrate translocation pore; other site 716540006765 Signal peptide predicted for EAM_1333 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.473 between residues 25 and 26 716540006766 12 transmembrane helices predicted for EAM_1333 by TMHMM2.0 at aa 7-29, 44-66, 73-92, 97-119, 132-151, 161-183, 205-227, 237-259, 266-288, 292-314, 327-349 and 353-370 716540006767 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.1e-26 716540006768 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 716540006769 PS00017 ATP/GTP-binding site motif A (P-loop). 716540006770 uncharacterized domain; Region: TIGR00702 716540006771 YcaO-like family; Region: YcaO; pfam02624 716540006772 HMMPfam hit to PF02624, YcaO-like family, score 7.8e-156 716540006773 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 716540006774 homodimer interface [polypeptide binding]; other site 716540006775 substrate-cofactor binding pocket; other site 716540006776 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716540006777 catalytic residue [active] 716540006778 HMMPfam hit to PF00266, Aminotransferase class-V, score 5.4e-68 716540006779 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 716540006780 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 716540006781 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 716540006782 hinge; other site 716540006783 active site 716540006784 HMMPfam hit to PF00275, EPSP synthase (3-phosphoshikimate 1-car, score 5.6e-211 716540006785 PS00104 EPSP synthase signature 1. 716540006786 PS00885 EPSP synthase signature 2. 716540006787 cytidylate kinase; Provisional; Region: cmk; PRK00023 716540006788 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 716540006789 CMP-binding site; other site 716540006790 The sites determining sugar specificity; other site 716540006791 HMMPfam hit to PF02224, Cytidylate kinase, score 1.5e-82 716540006792 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 716540006793 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 716540006794 RNA binding site [nucleotide binding]; other site 716540006795 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 716540006796 RNA binding site [nucleotide binding]; other site 716540006797 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 716540006798 RNA binding site [nucleotide binding]; other site 716540006799 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 716540006800 RNA binding site [nucleotide binding]; other site 716540006801 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 716540006802 RNA binding site [nucleotide binding]; other site 716540006803 HMMPfam hit to PF00575, S1 RNA binding domain, score 2.4e-12 716540006804 HMMPfam hit to PF00575, S1 RNA binding domain, score 1.2e-17 716540006805 HMMPfam hit to PF00575, S1 RNA binding domain, score 3.8e-32 716540006806 HMMPfam hit to PF00575, S1 RNA binding domain, score 4.1e-30 716540006807 HMMPfam hit to PF00575, S1 RNA binding domain, score 1.5e-26 716540006808 HMMPfam hit to PF00575, S1 RNA binding domain, score 2.8e-22 716540006809 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 716540006810 IHF dimer interface [polypeptide binding]; other site 716540006811 IHF - DNA interface [nucleotide binding]; other site 716540006812 HMMPfam hit to PF00216, Bacterial DNA-binding protein, score 5.7e-46 716540006813 PS00045 Bacterial histone-like DNA-binding proteins signature. 716540006814 ComEC family competence protein; Provisional; Region: PRK11539 716540006815 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 716540006816 Competence protein; Region: Competence; pfam03772 716540006817 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 716540006818 8 transmembrane helices predicted for EAM_1342 by TMHMM2.0 at aa 5-22, 27-44, 51-73, 223-245, 258-280, 329-351, 364-386 and 396-418 716540006819 HMMPfam hit to PF03772, Competence protein, score 2.2e-56 716540006820 HMMPfam hit to PF00753, Metallo-beta-lactamase superfamily, score 1.1e-16 716540006821 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 716540006822 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 716540006823 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 716540006824 Walker A/P-loop; other site 716540006825 ATP binding site [chemical binding]; other site 716540006826 Q-loop/lid; other site 716540006827 ABC transporter signature motif; other site 716540006828 Walker B; other site 716540006829 D-loop; other site 716540006830 H-loop/switch region; other site 716540006831 6 transmembrane helices predicted for EAM_1343 by TMHMM2.0 at aa 21-43, 63-80, 144-163, 167-186, 245-267 and 272-294 716540006832 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 8.8e-62 716540006833 HMMPfam hit to PF00005, ABC transporter, score 2e-61 716540006834 PS00017 ATP/GTP-binding site motif A (P-loop). 716540006835 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 716540006836 PS00211 ABC transporters family signature. 716540006837 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 716540006838 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 716540006839 HMMPfam hit to PF02606, Tetraacyldisaccharide-1-P 4'-kinase, score 1.3e-142 716540006840 1 transmembrane helix predicted for EAM_1344 by TMHMM2.0 at aa 12-34 716540006841 Trm112p-like protein; Region: Trm112p; cl01066 716540006842 HMMPfam hit to PF03966, Trm112p-like protein, score 3.3e-22 716540006843 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 716540006844 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 716540006845 Ligand binding site; other site 716540006846 oligomer interface; other site 716540006847 HMMPfam hit to PF02348, Cytidylyltransferase, score 3.9e-86 716540006848 hypothetical protein; Provisional; Region: PRK10593 716540006849 Uncharacterized conserved protein [Function unknown]; Region: COG1434 716540006850 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 716540006851 putative active site [active] 716540006852 HMMPfam hit to PF02698, DUF218 domain, score 4.2e-42 716540006853 2 transmembrane helices predicted for EAM_1348 by TMHMM2.0 at aa 13-35 and 42-59 716540006854 Signal peptide predicted for EAM_1348 by SignalP 2.0 HMM (Signal peptide probability 0.969) with cleavage site probability 0.516 between residues 36 and 37 716540006855 Methyltransferase domain; Region: Methyltransf_23; pfam13489 716540006856 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716540006857 S-adenosylmethionine binding site [chemical binding]; other site 716540006858 HMMPfam hit to PF08241, Methyltransferase domain, score 1.3e-21 716540006859 HMMPfam hit to PF08242, Methyltransferase domain, score 4.9e-19 716540006860 condesin subunit F; Provisional; Region: PRK05260 716540006861 HMMPfam hit to PF03882, KicB killing factor, score 0 716540006862 PS00430 TonB-dependent receptor proteins signature 1. 716540006863 condesin subunit E; Provisional; Region: PRK05256 716540006864 HMMPfam hit to PF04288, MukE-like family, score 5.3e-146 716540006865 cell division protein MukB; Provisional; Region: mukB; PRK04863 716540006866 P-loop containing region of AAA domain; Region: AAA_29; cl17516 716540006867 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 716540006868 HMMPfam hit to PF04310, MukB N-terminal, score 7.9e-171 716540006869 PS00017 ATP/GTP-binding site motif A (P-loop). 716540006870 murein L,D-transpeptidase; Provisional; Region: PRK10594 716540006871 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 716540006872 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 716540006873 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 716540006874 Signal peptide predicted for EAM_1353 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.792 between residues 30 and 31 716540006875 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540006876 HMMPfam hit to PF01471, peptidoglycan binding domain, score 7.3e-06 716540006877 PS00092 N-6 Adenine-specific DNA methylases signature. 716540006878 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 716540006879 Peptidase M15; Region: Peptidase_M15_3; cl01194 716540006880 Signal peptide predicted for EAM_1354 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 30 and 31 716540006881 1 transmembrane helix predicted for EAM_1354 by TMHMM2.0 at aa 12-34 716540006882 HMMPfam hit to PF05951, Bacterial protein of unknown function, score 1.4e-102 716540006883 HMMPfam hit to PF08291, Peptidase M15, score 3.4e-07 716540006884 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 716540006885 HMMPfam hit to PF00753, Metallo-beta-lactamase superfamily, score 7.7e-37 716540006886 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 716540006887 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 716540006888 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716540006889 homodimer interface [polypeptide binding]; other site 716540006890 catalytic residue [active] 716540006891 HMMPfam hit to PF00155, Aminotransferase class I and II, score 1.1e-128 716540006892 PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 716540006893 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 716540006894 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 716540006895 trimer interface [polypeptide binding]; other site 716540006896 eyelet of channel; other site 716540006897 HMMPfam hit to PF00267, Gram-negative porin, score 7.5e-178 716540006898 Signal peptide predicted for EAM_1357 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 22 and 23 716540006899 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 716540006900 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 716540006901 putative dimer interface [polypeptide binding]; other site 716540006902 putative anticodon binding site; other site 716540006903 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 716540006904 homodimer interface [polypeptide binding]; other site 716540006905 motif 1; other site 716540006906 motif 2; other site 716540006907 active site 716540006908 motif 3; other site 716540006909 HMMPfam hit to PF00152, tRNA synthetases class II (D, K and N), score 2.6e-81 716540006910 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 716540006911 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 716540006912 HMMPfam hit to PF01336, OB-fold nucleic acid binding domain, score 6.4e-20 716540006913 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 716540006914 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 716540006915 active site 716540006916 HMMPfam hit to PF04095, Nicotinate phosphoribosyltransferase (NAPRTa, score 3.2e-119 716540006917 aminopeptidase N; Provisional; Region: pepN; PRK14015 716540006918 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 716540006919 active site 716540006920 Zn binding site [ion binding]; other site 716540006921 HMMPfam hit to PF01433, Peptidase family M1, score 9e-65 716540006922 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 716540006923 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 716540006924 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 716540006925 Walker A/P-loop; other site 716540006926 ATP binding site [chemical binding]; other site 716540006927 Q-loop/lid; other site 716540006928 ABC transporter signature motif; other site 716540006929 Walker B; other site 716540006930 D-loop; other site 716540006931 H-loop/switch region; other site 716540006932 HMMPfam hit to PF00005, ABC transporter, score 1.6e-55 716540006933 PS00211 ABC transporters family signature. 716540006934 PS00017 ATP/GTP-binding site motif A (P-loop). 716540006935 PS00017 ATP/GTP-binding site motif A (P-loop). 716540006936 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 716540006937 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540006938 dimer interface [polypeptide binding]; other site 716540006939 conserved gate region; other site 716540006940 putative PBP binding loops; other site 716540006941 ABC-ATPase subunit interface; other site 716540006942 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 4.1e-36 716540006943 7 transmembrane helices predicted for EAM_1362 by TMHMM2.0 at aa 12-34, 64-86, 106-123, 128-150, 163-185, 189-211 and 223-245 716540006944 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 716540006945 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 716540006946 active site 716540006947 dimer interface [polypeptide binding]; other site 716540006948 non-prolyl cis peptide bond; other site 716540006949 insertion regions; other site 716540006950 HMMPfam hit to PF00296, Luciferase-like monooxygenase, score 5.9e-05 716540006951 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 716540006952 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 716540006953 substrate binding pocket [chemical binding]; other site 716540006954 membrane-bound complex binding site; other site 716540006955 hinge residues; other site 716540006956 HMMPfam hit to PF04069, Substrate binding domain of ABC-type glycine, score 0.0016 716540006957 Signal peptide predicted for EAM_1364 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.988 between residues 24 and 25 716540006958 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 716540006959 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 716540006960 HMMPfam hit to PF03358, NADPH-dependent FMN reductase, score 1.4e-46 716540006961 HMMPfam hit to PF02525, Flavodoxin-like fold, score 9.4e-05 716540006962 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 716540006963 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 716540006964 quinone interaction residues [chemical binding]; other site 716540006965 active site 716540006966 catalytic residues [active] 716540006967 FMN binding site [chemical binding]; other site 716540006968 substrate binding site [chemical binding]; other site 716540006969 HMMPfam hit to PF01180, Dihydroorotate dehydrogenase, score 3.5e-107 716540006970 PS00911 Dihydroorotate dehydrogenase signature 1. 716540006971 PS00912 Dihydroorotate dehydrogenase signature 2. 716540006972 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 716540006973 HMMPfam hit to PF07126, Protein of unknown function (DUF1379), score 2.6e-96 716540006974 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 716540006975 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 716540006976 MOSC domain; Region: MOSC; pfam03473 716540006977 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 716540006978 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 716540006979 catalytic loop [active] 716540006980 iron binding site [ion binding]; other site 716540006981 HMMPfam hit to PF00111, 2Fe-2S iron-sulfur cluster binding domain, score 1.9e-15 716540006982 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 716540006983 HMMPfam hit to PF03473, MOSC domain, score 2.2e-39 716540006984 HMMPfam hit to PF03476, MOSC N-terminal beta barrel domain, score 1.5e-40 716540006985 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 716540006986 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 716540006987 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 716540006988 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 716540006989 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716540006990 S-adenosylmethionine binding site [chemical binding]; other site 716540006991 HMMPfam hit to PF02926, THUMP domain, score 3.2e-16 716540006992 HMMPfam hit to PF01170, RNA methylase family UPF0020, score 5e-86 716540006993 PS01261 Uncharacterized protein family UPF0020 signature. 716540006994 PS00092 N-6 Adenine-specific DNA methylases signature. 716540006995 ABC transporter ATPase component; Reviewed; Region: PRK11147 716540006996 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 716540006997 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 716540006998 ABC transporter; Region: ABC_tran_2; pfam12848 716540006999 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 716540007000 HMMPfam hit to PF00005, ABC transporter, score 6.9e-48 716540007001 PS00017 ATP/GTP-binding site motif A (P-loop). 716540007002 PS00211 ABC transporters family signature. 716540007003 HMMPfam hit to PF00005, ABC transporter, score 4e-44 716540007004 PS00017 ATP/GTP-binding site motif A (P-loop). 716540007005 PS00211 ABC transporters family signature. 716540007006 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 716540007007 Paraquat-inducible protein A; Region: PqiA; pfam04403 716540007008 Paraquat-inducible protein A; Region: PqiA; pfam04403 716540007009 HMMPfam hit to PF04403, Paraquat-inducible protein A, score 3.6e-68 716540007010 8 transmembrane helices predicted for EAM_1371 by TMHMM2.0 at aa 53-75, 103-125, 138-160, 164-183, 256-278, 293-315, 352-374 and 379-401 716540007011 HMMPfam hit to PF04403, Paraquat-inducible protein A, score 6.9e-87 716540007012 paraquat-inducible protein B; Provisional; Region: PRK10807 716540007013 mce related protein; Region: MCE; pfam02470 716540007014 mce related protein; Region: MCE; pfam02470 716540007015 mce related protein; Region: MCE; pfam02470 716540007016 1 transmembrane helix predicted for EAM_1372 by TMHMM2.0 at aa 7-29 716540007017 HMMPfam hit to PF02470, mce related protein, score 1.3e-22 716540007018 HMMPfam hit to PF02470, mce related protein, score 1e-14 716540007019 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 716540007020 Protein of unknown function (DUF330); Region: DUF330; pfam03886 716540007021 Signal peptide predicted for EAM_1373 by SignalP 2.0 HMM (Signal peptide probability 0.987) with cleavage site probability 0.514 between residues 17 and 18 716540007022 HMMPfam hit to PF03886, Protein of unknown function (DUF330), score 1.5e-57 716540007023 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540007024 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 716540007025 active site 1 [active] 716540007026 dimer interface [polypeptide binding]; other site 716540007027 active site 2 [active] 716540007028 HMMPfam hit to PF07977, FabA-like domain, score 4e-78 716540007029 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 716540007030 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 716540007031 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 716540007032 HMMPfam hit to PF06303, Protein of unknown function (DUF1047), score 4.6e-112 716540007033 outer membrane protein A; Reviewed; Region: PRK10808 716540007034 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 716540007035 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 716540007036 ligand binding site [chemical binding]; other site 716540007037 HMMPfam hit to PF00691, OmpA family, score 3e-46 716540007038 PS01068 OmpA-like domain. 716540007039 HMMPfam hit to PF01389, OmpA-like transmembrane domain, score 6.6e-111 716540007040 Signal peptide predicted for EAM_1377 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.993 between residues 21 and 22 716540007041 SOS cell division inhibitor; Provisional; Region: PRK10595 716540007042 HMMPfam hit to PF03846, Cell division inhibitor SulA, score 3.4e-55 716540007043 TfoX N-terminal domain; Region: TfoX_N; pfam04993 716540007044 TfoX C-terminal domain; Region: TfoX_C; pfam04994 716540007045 HMMPfam hit to PF04993, TfoX N-terminal domain, score 1.3e-09 716540007046 HMMPfam hit to PF04994, TfoX C-terminal domain, score 6.3e-16 716540007047 TIGR01666 family membrane protein; Region: YCCS 716540007048 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 716540007049 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 716540007050 HMMPfam hit to PF05976, Bacterial membrane protein of unknown functi, score 0 716540007051 9 transmembrane helices predicted for EAM_1380 by TMHMM2.0 at aa 13-35, 39-56, 69-87, 91-110, 117-139, 143-165, 440-462, 482-504 and 511-533 716540007052 hypothetical protein; Provisional; Region: PRK11770 716540007053 Domain of unknown function (DUF307); Region: DUF307; pfam03733 716540007054 Domain of unknown function (DUF307); Region: DUF307; pfam03733 716540007055 HMMPfam hit to PF03733, Domain of unknown function (DUF307), score 4.6e-31 716540007056 3 transmembrane helices predicted for EAM_1381 by TMHMM2.0 at aa 15-37, 77-99 and 104-126 716540007057 HMMPfam hit to PF03733, Domain of unknown function (DUF307), score 1.1e-17 716540007058 DNA helicase IV; Provisional; Region: helD; PRK11054 716540007059 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 716540007060 Part of AAA domain; Region: AAA_19; pfam13245 716540007061 Family description; Region: UvrD_C_2; pfam13538 716540007062 HMMPfam hit to PF00580, UvrD/REP helicase, score 4.6e-10 716540007063 PS00017 ATP/GTP-binding site motif A (P-loop). 716540007064 HMMPfam hit to PF02142, MGS-like domain, score 5.5e-25 716540007065 PS01335 Methylglyoxal synthase active site. 716540007066 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437 716540007067 Signal peptide predicted for EAM_1384 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.950 between residues 21 and 22 716540007068 heat shock protein HspQ; Provisional; Region: PRK14129 716540007069 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 716540007070 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 716540007071 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 716540007072 putative RNA binding site [nucleotide binding]; other site 716540007073 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716540007074 S-adenosylmethionine binding site [chemical binding]; other site 716540007075 PS00294 Prenyl group binding site (CAAX box). 716540007076 PS01109 Ribosomal protein L10 signature. 716540007077 Acylphosphatase; Region: Acylphosphatase; cl00551 716540007078 HMMPfam hit to PF00708, Acylphosphatase, score 4.4e-07 716540007079 PS00150 Acylphosphatase signature 1. 716540007080 PS00151 Acylphosphatase signature 2. 716540007081 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 716540007082 sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342 716540007083 HMMPfam hit to PF04358, DsrC like protein, score 1.8e-73 716540007084 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 716540007085 YccA-like proteins; Region: YccA_like; cd10433 716540007086 HMMPfam hit to PF01027, Uncharacterised protein family UPF0005, score 5.8e-50 716540007087 7 transmembrane helices predicted for EAM_1390 by TMHMM2.0 at aa 24-46, 51-68, 75-97, 102-124, 131-153, 158-177 and 190-212 716540007088 PS01243 Uncharacterized protein family UPF0005 signature. 716540007089 Signal peptide predicted for EAM_1390 by SignalP 2.0 HMM (Signal peptide probability 0.982) with cleavage site probability 0.646 between residues 45 and 46 716540007090 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 716540007091 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 716540007092 catalytic core [active] 716540007093 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 716540007094 Signal peptide predicted for EAM_1391 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.888 between residues 23 and 24 716540007095 HMMPfam hit to PF00328, Histidine acid phosphatase, score 1.4e-47 716540007096 PS00616 Histidine acid phosphatases phosphohistidine signature. 716540007097 PS00778 Histidine acid phosphatases active site signature. 716540007098 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 716540007099 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 716540007100 NAD(P) binding site [chemical binding]; other site 716540007101 catalytic residues [active] 716540007102 HMMPfam hit to PF00171, Aldehyde dehydrogenase family, score 8.7e-151 716540007103 PS00070 Aldehyde dehydrogenases cysteine active site. 716540007104 PS00687 Aldehyde dehydrogenases glutamic acid active site. 716540007105 hypothetical protein; Provisional; Region: PRK10174 716540007106 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 716540007107 EamA-like transporter family; Region: EamA; pfam00892 716540007108 8 transmembrane helices predicted for EAM_1395 by TMHMM2.0 at aa 17-39, 43-65, 78-97, 102-121, 126-148, 158-179, 186-203 and 263-285 716540007109 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 1.1e-17 716540007110 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 5.5e-05 716540007111 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 716540007112 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 716540007113 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 716540007114 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 5.6e-20 716540007115 Predicted helix-turn-helix motif with score 1347.000, SD 3.77 at aa 42-63, sequence TTLDKVAERAGVSKTNLLYYFP 716540007116 HMMPfam hit to PF08362, YcdC-like protein, C-terminal region, score 1.1e-79 716540007117 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 716540007118 HMMPfam hit to PF04307, Predicted membrane-bound metal-dependent hyd, score 1.6e-14 716540007119 4 transmembrane helices predicted for EAM_1397 by TMHMM2.0 at aa 62-81, 94-116, 126-148 and 160-182 716540007120 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 716540007121 HMMPfam hit to PF00324, Amino acid permease, score 8.5e-135 716540007122 12 transmembrane helices predicted for EAM_1398 by TMHMM2.0 at aa 27-44, 48-70, 107-129, 134-156, 161-183, 213-235, 248-270, 285-307, 342-364, 374-396, 416-434 and 439-458 716540007123 PS00218 Amino acid permeases signature. 716540007124 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 716540007125 Autoinducer binding domain; Region: Autoind_bind; pfam03472 716540007126 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 716540007127 DNA binding residues [nucleotide binding] 716540007128 dimerization interface [polypeptide binding]; other site 716540007129 HMMPfam hit to PF03472, Autoinducer binding domain, score 3.4e-18 716540007130 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR fami, score 5.4e-19 716540007131 Predicted helix-turn-helix motif with score 1230.000, SD 3.38 at aa 195-216, sequence KTSAEISLILSISQNTVNFHQK 716540007132 Autoinducer synthetase; Region: Autoind_synth; cl17404 716540007133 GlpM protein; Region: GlpM; pfam06942 716540007134 HMMPfam hit to PF06942, GlpM protein, score 3.6e-66 716540007135 4 transmembrane helices predicted for EAM_1402 by TMHMM2.0 at aa 2-21, 25-47, 59-81 and 85-107 716540007136 hypothetical protein; Provisional; Region: PRK10613 716540007137 response regulator; Provisional; Region: PRK09483 716540007138 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716540007139 active site 716540007140 phosphorylation site [posttranslational modification] 716540007141 intermolecular recognition site; other site 716540007142 dimerization interface [polypeptide binding]; other site 716540007143 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 716540007144 DNA binding residues [nucleotide binding] 716540007145 dimerization interface [polypeptide binding]; other site 716540007146 HMMPfam hit to PF00072, Response regulator receiver domain, score 3.6e-41 716540007147 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR fami, score 6.7e-22 716540007148 PS00622 Bacterial regulatory proteins, luxR family signature. 716540007149 Predicted helix-turn-helix motif with score 1026.000, SD 2.68 at aa 165-186, sequence QKVTEISEQLNLSPKTVNSYRY 716540007150 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 716540007151 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 716540007152 GIY-YIG motif/motif A; other site 716540007153 active site 716540007154 catalytic site [active] 716540007155 putative DNA binding site [nucleotide binding]; other site 716540007156 metal binding site [ion binding]; metal-binding site 716540007157 UvrB/uvrC motif; Region: UVR; pfam02151 716540007158 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 716540007159 HMMPfam hit to PF01541, GIY-YIG catalytic domain, score 4.6e-32 716540007160 HMMPfam hit to PF02151, UvrB/uvrC motif, score 1.1e-11 716540007161 PS00216 Sugar transport proteins signature 1. 716540007162 HMMPfam hit to PF08459, UvrC Helix-hairpin-helix N-terminal, score 6.7e-89 716540007163 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 0.00055 716540007164 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 716540007165 Signal peptide predicted for EAM_1406 by SignalP 2.0 HMM (Signal peptide probability 0.605) with cleavage site probability 0.501 between residues 23 and 24 716540007166 4 transmembrane helices predicted for EAM_1406 by TMHMM2.0 at aa 7-26, 30-52, 121-143 and 147-169 716540007167 HMMPfam hit to PF01066, CDP-alcohol phosphatidyltransferase, score 6.3e-46 716540007168 PS00379 CDP-alcohol phosphatidyltransferases signature. 716540007169 Transposase; Region: HTH_Tnp_1; cl17663 716540007170 HMMPfam hit to PF01527, Transposase, score 0.0028 716540007171 Predicted helix-turn-helix motif with score 1530.000, SD 4.40 at aa 117-138, sequence ESVTGLARKYDIPYSTIWNWVK 716540007172 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 716540007173 MarR family; Region: MarR; pfam01047 716540007174 HMMPfam hit to PF01047, MarR family, score 3.1e-18 716540007175 Predicted helix-turn-helix motif with score 1192.000, SD 3.25 at aa 50-71, sequence MNQKELAQALGLEDASVVPLID 716540007176 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540007177 Major Facilitator Superfamily; Region: MFS_1; pfam07690 716540007178 putative substrate translocation pore; other site 716540007179 14 transmembrane helices predicted for EAM_1409 by TMHMM2.0 at aa 38-60, 75-94, 101-123, 128-150, 163-183, 193-215, 228-250, 254-276, 288-310, 330-352, 357-376, 391-413, 420-442 and 513-535 716540007180 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.6e-07 716540007181 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 716540007182 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 716540007183 HlyD family secretion protein; Region: HlyD_3; pfam13437 716540007184 1 transmembrane helix predicted for EAM_1410 by TMHMM2.0 at aa 20-42 716540007185 HMMPfam hit to PF00529, HlyD family secretion protein, score 1.1e-27 716540007186 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 716540007187 Signal peptide predicted for EAM_1411 by SignalP 2.0 HMM (Signal peptide probability 0.856) with cleavage site probability 0.513 between residues 26 and 27 716540007188 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540007189 HMMPfam hit to PF02321, Outer membrane efflux protein, score 8.4e-32 716540007190 HMMPfam hit to PF02321, Outer membrane efflux protein, score 2.9e-29 716540007191 1 transmembrane helix predicted for EAM_1414 by TMHMM2.0 at aa 47-69 716540007192 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 716540007193 PLD-like domain; Region: PLDc_2; pfam13091 716540007194 putative active site [active] 716540007195 catalytic site [active] 716540007196 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 716540007197 PLD-like domain; Region: PLDc_2; pfam13091 716540007198 putative active site [active] 716540007199 catalytic site [active] 716540007200 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 0.02 716540007201 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 0.0033 716540007202 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 716540007203 Acyltransferase family; Region: Acyl_transf_3; pfam01757 716540007204 HMMPfam hit to PF01757, Acyltransferase family, score 8.2e-25 716540007205 10 transmembrane helices predicted for EAM_1416 by TMHMM2.0 at aa 17-39, 54-76, 88-110, 137-159, 171-193, 208-230, 237-259, 274-293, 306-328 and 338-355 716540007206 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 716540007207 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 716540007208 Signal peptide predicted for EAM_1417 by SignalP 2.0 HMM (Signal peptide probability 0.992) with cleavage site probability 0.787 between residues 21 and 22 716540007209 HMMPfam hit to PF04349, Periplasmic glucan biosynthesis protein, Mdo, score 0 716540007210 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 716540007211 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 716540007212 Ligand binding site; other site 716540007213 DXD motif; other site 716540007214 6 transmembrane helices predicted for EAM_1418 by TMHMM2.0 at aa 148-165, 203-225, 521-543, 577-599, 612-634 and 689-711 716540007215 HMMPfam hit to PF00535, Glycosyl transferase family, score 6e-10 716540007216 lipoprotein; Provisional; Region: PRK10175 716540007217 HMMPfam hit to PF07119, Protein of unknown function (DUF1375), score 5.1e-25 716540007218 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540007219 secY/secA suppressor protein; Provisional; Region: PRK11467 716540007220 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 716540007221 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 716540007222 putative acyl-acceptor binding pocket; other site 716540007223 HMMPfam hit to PF03279, Bacterial lipid A biosynthesis acyltr, score 2.1e-140 716540007224 1 transmembrane helix predicted for EAM_1421 by TMHMM2.0 at aa 23-45 716540007225 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 716540007226 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 716540007227 active site residue [active] 716540007228 PS00017 ATP/GTP-binding site motif A (P-loop). 716540007229 HMMPfam hit to PF00581, Rhodanese-like domain, score 6.2e-25 716540007230 hypothetical protein; Provisional; Region: PRK03757 716540007231 HMMPfam hit to PF04264, YceI like family, score 5.9e-76 716540007232 Signal peptide predicted for EAM_1423 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.931 between residues 23 and 24 716540007233 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 716540007234 HMMPfam hit to PF01292, Cytochrome b561 family, score 1.3e-63 716540007235 4 transmembrane helices predicted for EAM_1424 by TMHMM2.0 at aa 13-35, 55-72, 92-114 and 147-169 716540007236 Signal peptide predicted for EAM_1424 by SignalP 2.0 HMM (Signal peptide probability 0.718) with cleavage site probability 0.315 between residues 35 and 36 716540007237 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 716540007238 hydroxyglutarate oxidase; Provisional; Region: PRK11728 716540007239 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 1.9e-53 716540007240 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 716540007241 DNA damage-inducible protein I; Provisional; Region: PRK10597 716540007242 HMMPfam hit to PF06183, DinI-like family, score 1.7e-30 716540007243 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 716540007244 active site 716540007245 substrate binding pocket [chemical binding]; other site 716540007246 dimer interface [polypeptide binding]; other site 716540007247 HMMPfam hit to PF01979, Amidohydrolase family, score 1.6e-64 716540007248 PS00483 Dihydroorotase signature 2. 716540007249 PS00482 Dihydroorotase signature 1. 716540007250 lipoprotein; Provisional; Region: PRK10598 716540007251 HMMPfam hit to PF07273, Protein of unknown function (DUF1439), score 3.5e-100 716540007252 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540007253 Signal peptide predicted for EAM_1431 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.506 between residues 19 and 20 716540007254 glutaredoxin 2; Provisional; Region: PRK10387 716540007255 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 716540007256 C-terminal domain interface [polypeptide binding]; other site 716540007257 GSH binding site (G-site) [chemical binding]; other site 716540007258 catalytic residues [active] 716540007259 putative dimer interface [polypeptide binding]; other site 716540007260 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 716540007261 N-terminal domain interface [polypeptide binding]; other site 716540007262 HMMPfam hit to PF04399, Glutaredoxin 2, C terminal domain, score 6.7e-62 716540007263 PS00195 Glutaredoxin active site. 716540007264 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 716540007265 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 716540007266 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 9.1e-10 716540007267 Signal peptide predicted for EAM_1434 by SignalP 2.0 HMM (Signal peptide probability 0.890) with cleavage site probability 0.888 between residues 26 and 27 716540007268 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540007269 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 716540007270 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 716540007271 Signal peptide predicted for EAM_1435 by SignalP 2.0 HMM (Signal peptide probability 0.964) with cleavage site probability 0.769 between residues 23 and 24 716540007272 13 transmembrane helices predicted for EAM_1435 by TMHMM2.0 at aa 26-45, 82-104, 128-150, 157-179, 184-203, 237-259, 274-296, 316-338, 353-375, 380-402, 407-429, 442-464 and 479-501 716540007273 HMMPfam hit to PF03023, MviN-like protein, score 1.1e-194 716540007274 Predicted helix-turn-helix motif with score 996.000, SD 2.58 at aa 229-250, sequence VMRQMGPAILGVSVSQISLIIN 716540007275 FlgN protein; Region: FlgN; cl09176 716540007276 HMMPfam hit to PF05130, FlgN protein, score 1.4e-26 716540007277 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 716540007278 HMMPfam hit to PF04316, Anti-sigma-28 factor, FlgM, score 1.8e-18 716540007279 SAF-like; Region: SAF_2; pfam13144 716540007280 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 716540007281 HMMPfam hit to PF03240, FlgA family, score 2.5e-61 716540007282 Signal peptide predicted for EAM_1438 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.987 between residues 21 and 22 716540007283 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 716540007284 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 716540007285 HMMPfam hit to PF00460, Flagella basal body rod protein, score 1.2e-11 716540007286 PS00588 Flagella basal body rod proteins signature. 716540007287 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 716540007288 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 716540007289 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 716540007290 HMMPfam hit to PF00460, Flagella basal body rod protein, score 1.1e-09 716540007291 PS00588 Flagella basal body rod proteins signature. 716540007292 HMMPfam hit to PF06429, Domain of unknown function (DUF1078), score 2.5e-06 716540007293 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 716540007294 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 716540007295 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 716540007296 HMMPfam hit to PF03963, Flagellar hook capping protein, score 7.4e-41 716540007297 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 716540007298 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 716540007299 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 716540007300 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 716540007301 HMMPfam hit to PF00460, Flagella basal body rod protein, score 2.3e-11 716540007302 PS00588 Flagella basal body rod proteins signature. 716540007303 HMMPfam hit to PF07559, Flagellar basal body protein FlaE, score 2.2e-26 716540007304 HMMPfam hit to PF06429, Domain of unknown function (DUF1078), score 6.8e-20 716540007305 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 716540007306 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 716540007307 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 716540007308 HMMPfam hit to PF00460, Flagella basal body rod protein, score 6e-11 716540007309 PS00588 Flagella basal body rod proteins signature. 716540007310 HMMPfam hit to PF06429, Domain of unknown function (DUF1078), score 0.0073 716540007311 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 716540007312 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 716540007313 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 716540007314 HMMPfam hit to PF00460, Flagella basal body rod protein, score 5.3e-15 716540007315 PS00588 Flagella basal body rod proteins signature. 716540007316 HMMPfam hit to PF06429, Domain of unknown function (DUF1078), score 4.3e-19 716540007317 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 716540007318 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 716540007319 HMMPfam hit to PF02107, Flagellar L-ring protein, score 5.7e-88 716540007320 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 716540007321 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 716540007322 Signal peptide predicted for EAM_1446 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.923 between residues 22 and 23 716540007323 HMMPfam hit to PF02119, Flagellar P-ring protein, score 5.4e-200 716540007324 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 716540007325 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 716540007326 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 716540007327 HMMPfam hit to PF01832, Mannosyl-glycoprotein endo-beta-N-ace, score 2.7e-55 716540007328 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 716540007329 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 716540007330 Signal peptide predicted for EAM_1448 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.349 between residues 20 and 21 716540007331 HMMPfam hit to PF00460, Flagella basal body rod protein, score 1.6e-07 716540007332 HMMPfam hit to PF06429, Domain of unknown function (DUF1078), score 1.4e-14 716540007333 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 716540007334 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 716540007335 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 716540007336 HMMPfam hit to PF00669, Bacterial flagellin N-terminus, score 7.1e-17 716540007337 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 716540007338 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 716540007339 homodimer interface [polypeptide binding]; other site 716540007340 oligonucleotide binding site [chemical binding]; other site 716540007341 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 716540007342 HMMPfam hit to PF00575, S1 RNA binding domain, score 1.9e-19 716540007343 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 716540007344 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 716540007345 RNA binding surface [nucleotide binding]; other site 716540007346 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 716540007347 active site 716540007348 HMMPfam hit to PF01479, S4 domain, score 2e-11 716540007349 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 4.1e-53 716540007350 PS01129 Rlu family of pseudouridine synthase signature. 716540007351 Maf-like protein; Region: Maf; pfam02545 716540007352 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 716540007353 active site 716540007354 dimer interface [polypeptide binding]; other site 716540007355 HMMPfam hit to PF02545, Maf-like protein, score 2.2e-69 716540007356 hypothetical protein; Provisional; Region: PRK11193 716540007357 HMMPfam hit to PF02620, Uncharacterized ACR, COG1399, score 8.1e-50 716540007358 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 716540007359 HMMPfam hit to PF01783, Ribosomal L32p protein family, score 2.1e-22 716540007360 putative phosphate acyltransferase; Provisional; Region: PRK05331 716540007361 HMMPfam hit to PF02504, Fatty acid synthesis protein, score 1.7e-154 716540007362 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 716540007363 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 716540007364 dimer interface [polypeptide binding]; other site 716540007365 active site 716540007366 CoA binding pocket [chemical binding]; other site 716540007367 HMMPfam hit to PF08545, 3-Oxoacyl-[acyl-carrier-protein (ACP)], score 2.1e-44 716540007368 HMMPfam hit to PF08541, 3-Oxoacyl-[acyl-carrier-protein (ACP)], score 2e-54 716540007369 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 716540007370 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 716540007371 HMMPfam hit to PF00698, Acyl transferase domain, score 2.8e-12 716540007372 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 716540007373 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 716540007374 NAD(P) binding site [chemical binding]; other site 716540007375 homotetramer interface [polypeptide binding]; other site 716540007376 homodimer interface [polypeptide binding]; other site 716540007377 active site 716540007378 HMMPfam hit to PF00106, short chain dehydrogenase, score 7.1e-40 716540007379 PS00061 Short-chain dehydrogenases/reductases family signature. 716540007380 acyl carrier protein; Provisional; Region: acpP; PRK00982 716540007381 HMMPfam hit to PF00550, Phosphopantetheine attachment site, score 9.1e-23 716540007382 PS00012 Phosphopantetheine attachment site. 716540007383 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 716540007384 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 716540007385 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 716540007386 dimer interface [polypeptide binding]; other site 716540007387 active site 716540007388 Signal peptide predicted for EAM_1460 by SignalP 2.0 HMM (Signal peptide probability 0.921) with cleavage site probability 0.749 between residues 20 and 21 716540007389 HMMPfam hit to PF00109, Beta-ketoacyl synthase, N-terminal do, score 3.4e-84 716540007390 PS00606 Beta-ketoacyl synthases active site. 716540007391 HMMPfam hit to PF02801, Beta-ketoacyl synthase, C-terminal do, score 8.7e-77 716540007392 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 716540007393 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 716540007394 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 716540007395 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716540007396 catalytic residue [active] 716540007397 HMMPfam hit to PF01063, Aminotransferase class IV, score 4.1e-35 716540007398 PS00770 Aminotransferases class-IV signature. 716540007399 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 716540007400 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 716540007401 dimerization interface [polypeptide binding]; other site 716540007402 Signal peptide predicted for EAM_1462 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.809 between residues 22 and 23 716540007403 1 transmembrane helix predicted for EAM_1462 by TMHMM2.0 at aa 7-24 716540007404 HMMPfam hit to PF02618, Aminodeoxychorismate lyase, score 9e-130 716540007405 thymidylate kinase; Validated; Region: tmk; PRK00698 716540007406 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 716540007407 TMP-binding site; other site 716540007408 ATP-binding site [chemical binding]; other site 716540007409 HMMPfam hit to PF02223, Thymidylate kinase, score 1.6e-75 716540007410 PS00017 ATP/GTP-binding site motif A (P-loop). 716540007411 PS01331 Thymidylate kinase signature. 716540007412 DNA polymerase III subunit delta'; Validated; Region: PRK07993 716540007413 DNA polymerase III subunit delta'; Validated; Region: PRK08485 716540007414 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 716540007415 PS00190 Cytochrome c family heme-binding site signature. 716540007416 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 716540007417 active site 716540007418 HMMPfam hit to PF01026, TatD related DNase, score 5.6e-119 716540007419 PS01137 Uncharacterized protein family UPF0006 signature 1. 716540007420 PS01090 Uncharacterized protein family UPF0006 signature 2. 716540007421 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 716540007422 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 716540007423 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 716540007424 active site turn [active] 716540007425 phosphorylation site [posttranslational modification] 716540007426 Signal peptide predicted for EAM_1466 by SignalP 2.0 HMM (Signal peptide probability 0.892) with cleavage site probability 0.701 between residues 49 and 50 716540007427 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 2.5e-107 716540007428 9 transmembrane helices predicted for EAM_1466 by TMHMM2.0 at aa 15-37, 49-71, 81-103, 116-138, 153-175, 250-272, 282-304, 309-331 and 354-376 716540007429 HMMPfam hit to PF00367, phosphotransferase system, EIIB, score 1.2e-16 716540007430 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 716540007431 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 716540007432 nucleotide binding site/active site [active] 716540007433 HIT family signature motif; other site 716540007434 catalytic residue [active] 716540007435 HMMPfam hit to PF01230, HIT domain, score 4.4e-47 716540007436 PS00892 HIT family signature. 716540007437 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 716540007438 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 716540007439 putative dimer interface [polypeptide binding]; other site 716540007440 Signal peptide predicted for EAM_1468 by SignalP 2.0 HMM (Signal peptide probability 0.892) with cleavage site probability 0.243 between residues 19 and 20 716540007441 HMMPfam hit to PF07233, Protein of unknown function (DUF1425), score 3.6e-28 716540007442 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540007443 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 716540007444 Signal peptide predicted for EAM_1469 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.560 between residues 24 and 25 716540007445 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540007446 thiamine kinase; Region: ycfN_thiK; TIGR02721 716540007447 active site 716540007448 substrate binding site [chemical binding]; other site 716540007449 ATP binding site [chemical binding]; other site 716540007450 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 716540007451 HMMPfam hit to PF01636, Phosphotransferase enzyme family, score 2.8e-18 716540007452 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 716540007453 beta-hexosaminidase; Provisional; Region: PRK05337 716540007454 HMMPfam hit to PF00933, Glycosyl hydrolase family 3 N terminal, score 7e-83 716540007455 PS00775 Glycosyl hydrolases family 3 active site. 716540007456 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 716540007457 HMMPfam hit to PF04303, Protein of unknown function (DUF453), score 1e-33 716540007458 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 716540007459 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 716540007460 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidoreduc, score 1.3e-30 716540007461 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreduc, score 0.0019 716540007462 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreduc, score 2.1e-20 716540007463 hypothetical protein; Provisional; Region: PRK11280 716540007464 Signal peptide predicted for EAM_1474 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.636 between residues 35 and 36 716540007465 1 transmembrane helix predicted for EAM_1474 by TMHMM2.0 at aa 7-29 716540007466 HMMPfam hit to PF05433, Rickettsia 17 kDa surface antigen, score 2.8e-13 716540007467 transcription-repair coupling factor; Provisional; Region: PRK10689 716540007468 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 716540007469 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 716540007470 ATP binding site [chemical binding]; other site 716540007471 putative Mg++ binding site [ion binding]; other site 716540007472 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 716540007473 nucleotide binding region [chemical binding]; other site 716540007474 ATP-binding site [chemical binding]; other site 716540007475 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 716540007476 HMMPfam hit to PF03461, TRCF domain, score 1.8e-52 716540007477 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 1.2e-20 716540007478 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 5.2e-40 716540007479 HMMPfam hit to PF04851, Type III restriction enzyme, res subunit, score 9.7e-07 716540007480 PS00017 ATP/GTP-binding site motif A (P-loop). 716540007481 HMMPfam hit to PF02559, CarD-like/TRCF domain, score 5.2e-50 716540007482 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 716540007483 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 716540007484 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716540007485 active site 716540007486 motif I; other site 716540007487 motif II; other site 716540007488 HMMPfam hit to PF05116, Sucrose-6F-phosphate phosphohydrolase, score 0.0011 716540007489 HMMPfam hit to PF08282, haloacid dehalogenase-like hydrolase, score 1.2e-06 716540007490 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 716540007491 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 716540007492 HMMPfam hit to PF01679, Uncharacterized protein family UPF0057, score 9.2e-21 716540007493 Signal peptide predicted for EAM_1480 by SignalP 2.0 HMM (Signal peptide probability 0.925) with cleavage site probability 0.738 between residues 24 and 25 716540007494 2 transmembrane helices predicted for EAM_1480 by TMHMM2.0 at aa 7-24 and 28-50 716540007495 PS01309 Uncharacterized protein family UPF0057 signature. 716540007496 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 716540007497 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 716540007498 DNA binding residues [nucleotide binding] 716540007499 dimerization interface [polypeptide binding]; other site 716540007500 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR family, score 1.3e-17 716540007501 PS00622 Bacterial regulatory proteins, luxR family signature. 716540007502 2 transmembrane helices predicted for EAM_1483 by TMHMM2.0 at aa 9-31 and 41-59 716540007503 Signal peptide predicted for EAM_1483 by SignalP 2.0 HMM (Signal peptide probability 0.680) with cleavage site probability 0.675 between residues 33 and 34 716540007504 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 716540007505 HMMPfam hit to PF01311, Bacterial export proteins, family, score 1.1e-85 716540007506 6 transmembrane helices predicted for EAM_1484 by TMHMM2.0 at aa 10-32, 44-63, 73-95, 125-147, 186-204 and 211-233 716540007507 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 716540007508 HMMPfam hit to PF01313, Bacterial export proteins, family, score 2.5e-36 716540007509 2 transmembrane helices predicted for EAM_1485 by TMHMM2.0 at aa 15-37 and 50-72 716540007510 Signal peptide predicted for EAM_1485 by SignalP 2.0 HMM (Signal peptide probability 0.908) with cleavage site probability 0.893 between residues 40 and 41 716540007511 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 716540007512 HMMPfam hit to PF00813, FliP family, score 3.2e-124 716540007513 5 transmembrane helices predicted for EAM_1486 by TMHMM2.0 at aa 7-26, 46-68, 88-105, 185-207 and 214-236 716540007514 PS01061 Flagella transport protein fliP family signature 2. 716540007515 PS01060 Flagella transport protein fliP family signature 1. 716540007516 Signal peptide predicted for EAM_1486 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 21 and 22 716540007517 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 716540007518 HMMPfam hit to PF04347, Flagellar biosynthesis protein, FliO, score 3.9e-30 716540007519 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540007520 1 transmembrane helix predicted for EAM_1487 by TMHMM2.0 at aa 20-42 716540007521 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 716540007522 HMMPfam hit to PF01052, Surface presentation of antigens (SPOA) prot, score 3.5e-37 716540007523 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 716540007524 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 716540007525 HMMPfam hit to PF02154, Flagellar motor switch protein FliM, score 9.1e-119 716540007526 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 716540007527 HMMPfam hit to PF03748, Flagellar basal body-associated protein FliL, score 1.2e-34 716540007528 1 transmembrane helix predicted for EAM_1490 by TMHMM2.0 at aa 13-35 716540007529 Signal peptide predicted for EAM_1490 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.326 between residues 31 and 32 716540007530 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540007531 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 716540007532 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 716540007533 HMMPfam hit to PF02120, Flagellar hook-length control protein, score 3.1e-29 716540007534 PS00017 ATP/GTP-binding site motif A (P-loop). 716540007535 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 716540007536 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 716540007537 HMMPfam hit to PF02050, Flagellar FliJ protein, score 1.4e-63 716540007538 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 716540007539 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 716540007540 Walker A motif/ATP binding site; other site 716540007541 Walker B motif; other site 716540007542 HMMPfam hit to PF00006, ATP synthase alpha/beta family, nucleotid, score 2.8e-121 716540007543 PS00152 ATP synthase alpha and beta subunits signature. 716540007544 PS00017 ATP/GTP-binding site motif A (P-loop). 716540007545 PS00136 Serine proteases, subtilase family, aspartic acid active site. 716540007546 flagellar assembly protein H; Validated; Region: fliH; PRK05687 716540007547 Flagellar assembly protein FliH; Region: FliH; pfam02108 716540007548 HMMPfam hit to PF02108, Flagellar assembly protein FliH, score 6.3e-77 716540007549 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 716540007550 FliG C-terminal domain; Region: FliG_C; pfam01706 716540007551 HMMPfam hit to PF01706, FliG C-terminal domain, score 2.5e-57 716540007552 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 716540007553 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 716540007554 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 716540007555 PS00014 Endoplasmic reticulum targeting sequence. 716540007556 HMMPfam hit to PF08345, Flagellar M-ring protein C-terminal, score 8.2e-85 716540007557 HMMPfam hit to PF01514, Secretory protein of YscJ/FliF family, score 4.7e-91 716540007558 1 transmembrane helix predicted for EAM_1496 by TMHMM2.0 at aa 28-47 716540007559 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 716540007560 HMMPfam hit to PF02049, Flagellar hook-basal body complex protein Fl, score 1.5e-30 716540007561 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 716540007562 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 716540007563 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716540007564 active site 716540007565 phosphorylation site [posttranslational modification] 716540007566 intermolecular recognition site; other site 716540007567 dimerization interface [polypeptide binding]; other site 716540007568 HMMPfam hit to PF01584, CheW-like domain, score 2.7e-28 716540007569 HMMPfam hit to PF00072, Response regulator receiver domain, score 6e-10 716540007570 Signal peptide predicted for EAM_1500 by SignalP 2.0 HMM (Signal peptide probability 0.810) with cleavage site probability 0.442 between residues 20 and 21 716540007571 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 716540007572 HMMPfam hit to PF06530, Phage antitermination protein Q, score 4.6e-37 716540007573 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 716540007574 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 716540007575 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 716540007576 metal binding site [ion binding]; metal-binding site 716540007577 active site 716540007578 I-site; other site 716540007579 HMMPfam hit to PF00990, GGDEF domain, score 1.6e-45 716540007580 6 transmembrane helices predicted for EAM_1504 by TMHMM2.0 at aa 7-26, 78-100, 113-135, 192-214, 221-243 and 263-285 716540007581 Signal peptide predicted for EAM_1504 by SignalP 2.0 HMM (Signal peptide probability 0.897) with cleavage site probability 0.552 between residues 25 and 26 716540007582 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 716540007583 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 716540007584 FtsX-like permease family; Region: FtsX; pfam02687 716540007585 4 transmembrane helices predicted for EAM_1505 by TMHMM2.0 at aa 25-47, 267-289, 310-332 and 360-382 716540007586 HMMPfam hit to PF02687, Predicted permease, score 9.1e-46 716540007587 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 716540007588 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 716540007589 Walker A/P-loop; other site 716540007590 ATP binding site [chemical binding]; other site 716540007591 Q-loop/lid; other site 716540007592 ABC transporter signature motif; other site 716540007593 Walker B; other site 716540007594 D-loop; other site 716540007595 H-loop/switch region; other site 716540007596 HMMPfam hit to PF00005, ABC transporter, score 2.8e-67 716540007597 PS00017 ATP/GTP-binding site motif A (P-loop). 716540007598 PS00211 ABC transporters family signature. 716540007599 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 716540007600 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 716540007601 FtsX-like permease family; Region: FtsX; pfam02687 716540007602 4 transmembrane helices predicted for EAM_1507 by TMHMM2.0 at aa 21-43, 270-292, 318-340 and 380-399 716540007603 HMMPfam hit to PF02687, Predicted permease, score 1.2e-52 716540007604 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 716540007605 NAD-dependent deacetylase; Provisional; Region: PRK00481 716540007606 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 716540007607 NAD+ binding site [chemical binding]; other site 716540007608 substrate binding site [chemical binding]; other site 716540007609 Zn binding site [ion binding]; other site 716540007610 HMMPfam hit to PF02146, Sir2 family, score 3.8e-78 716540007611 benzoate transporter; Region: benE; TIGR00843 716540007612 Benzoate membrane transport protein; Region: BenE; pfam03594 716540007613 HMMPfam hit to PF03594, Benzoate membrane transport protein, score 3.9e-183 716540007614 10 transmembrane helices predicted for EAM_1510 by TMHMM2.0 at aa 15-34, 47-69, 98-120, 127-149, 169-191, 204-226, 249-271, 291-313, 317-339 and 352-374 716540007615 HMMPfam hit to PF00860, Permease family, score 0.011 716540007616 Predicted helix-turn-helix motif with score 975.000, SD 2.51 at aa 49-70, sequence GWITVLGLAMGVTTLALSLWYR 716540007617 Signal peptide predicted for EAM_1510 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.561 between residues 39 and 40 716540007618 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 716540007619 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 716540007620 non-specific DNA binding site [nucleotide binding]; other site 716540007621 salt bridge; other site 716540007622 sequence-specific DNA binding site [nucleotide binding]; other site 716540007623 Cupin domain; Region: Cupin_2; pfam07883 716540007624 HMMPfam hit to PF01381, Helix-turn-helix, score 9.8e-14 716540007625 Predicted helix-turn-helix motif with score 1582.000, SD 4.58 at aa 21-42, sequence WSLAQAAQITGVSKAMLGQIER 716540007626 PS00133 Zinc carboxypeptidases, zinc-binding region 2 signature. 716540007627 HMMPfam hit to PF07883, Cupin domain, score 2.9e-12 716540007628 Uncharacterized conserved protein [Function unknown]; Region: COG2850 716540007629 Cupin-like domain; Region: Cupin_8; pfam13621 716540007630 HMMPfam hit to PF08007, Cupin superfamily protein, score 9.6e-147 716540007631 sensor protein PhoQ; Provisional; Region: PRK10815 716540007632 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 716540007633 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 716540007634 dimer interface [polypeptide binding]; other site 716540007635 phosphorylation site [posttranslational modification] 716540007636 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716540007637 ATP binding site [chemical binding]; other site 716540007638 Mg2+ binding site [ion binding]; other site 716540007639 G-X-G motif; other site 716540007640 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 5.2e-28 716540007641 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 8.9e-05 716540007642 HMMPfam hit to PF00672, HAMP domain, score 8e-08 716540007643 2 transmembrane helices predicted for EAM_1513 by TMHMM2.0 at aa 20-42 and 190-212 716540007644 Signal peptide predicted for EAM_1513 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.541 between residues 34 and 35 716540007645 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 716540007646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716540007647 active site 716540007648 phosphorylation site [posttranslational modification] 716540007649 intermolecular recognition site; other site 716540007650 dimerization interface [polypeptide binding]; other site 716540007651 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 716540007652 DNA binding site [nucleotide binding] 716540007653 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 2.7e-19 716540007654 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.2e-32 716540007655 adenylosuccinate lyase; Provisional; Region: PRK09285 716540007656 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 716540007657 tetramer interface [polypeptide binding]; other site 716540007658 active site 716540007659 HMMPfam hit to PF08328, Adenylosuccinate lyase C-terminal, score 7.2e-87 716540007660 HMMPfam hit to PF00206, Lyase, score 1.9e-92 716540007661 PS00163 Fumarate lyases signature. 716540007662 putative lysogenization regulator; Reviewed; Region: PRK00218 716540007663 HMMPfam hit to PF04356, Protein of unknown function (DUF489), score 2.8e-119 716540007664 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 716540007665 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 716540007666 HMMPfam hit to PF03054, tRNA methyl transferase, score 2.4e-218 716540007667 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 716540007668 nudix motif; other site 716540007669 HMMPfam hit to PF00293, NUDIX domain, score 2.5e-20 716540007670 PS00893 mutT domain signature. 716540007671 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 716540007672 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 716540007673 active site 716540007674 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 3.8e-17 716540007675 PS01149 Rsu family of pseudouridine synthase signature. 716540007676 isocitrate dehydrogenase; Validated; Region: PRK07362 716540007677 isocitrate dehydrogenase; Reviewed; Region: PRK07006 716540007678 HMMPfam hit to PF00180, Isocitrate/isopropylmalate dehydrogenase, score 7.1e-161 716540007679 PS00470 Isocitrate and isopropylmalate dehydrogenases signature. 716540007680 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 716540007681 Mig-14; Region: Mig-14; pfam07395 716540007682 HMMPfam hit to PF07395, Mig-14, score 2.3e-64 716540007683 Signal peptide predicted for EAM_1524 by SignalP 2.0 HMM (Signal peptide probability 0.954) with cleavage site probability 0.483 between residues 20 and 21 716540007684 3 transmembrane helices predicted for EAM_1524 by TMHMM2.0 at aa 29-48, 55-74 and 89-107 716540007685 Protein of unknown function (DUF754); Region: DUF754; pfam05449 716540007686 HMMPfam hit to PF05449, Protein of unknown function (DUF754), score 4.1e-26 716540007687 3 transmembrane helices predicted for EAM_1525 by TMHMM2.0 at aa 2-19, 29-50 and 57-74 716540007688 DinI-like family; Region: DinI; cl11630 716540007689 HMMPfam hit to PF06183, DinI-like family, score 1.1e-21 716540007690 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 716540007691 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 716540007692 dimer interface [polypeptide binding]; other site 716540007693 catalytic triad [active] 716540007694 HMMPfam hit to PF02016, LD-carboxypeptidase, score 1.5e-49 716540007695 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 716540007696 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 716540007697 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 716540007698 N-acetyl-D-glucosamine binding site [chemical binding]; other site 716540007699 catalytic residue [active] 716540007700 Signal peptide predicted for EAM_1530 by SignalP 2.0 HMM (Signal peptide probability 0.950) with cleavage site probability 0.681 between residues 22 and 23 716540007701 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540007702 HMMPfam hit to PF01464, Transglycosylase SLT domain, score 2e-31 716540007703 PS00922 Prokaryotic transglycosylases signature. 716540007704 hypothetical protein; Provisional; Region: PRK10457 716540007705 3 transmembrane helices predicted for EAM_1532 by TMHMM2.0 at aa 2-21, 31-53 and 60-77 716540007706 HMMPfam hit to PF04226, Transglycosylase associated protein, score 5.8e-20 716540007707 Trehalase; Region: Trehalase; cl17346 716540007708 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 716540007709 PS00017 ATP/GTP-binding site motif A (P-loop). 716540007710 HMMPfam hit to PF01204, Trehalase, score 7.3e-234 716540007711 PS00928 Trehalase signature 2. 716540007712 PS00927 Trehalase signature 1. 716540007713 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 716540007714 Signal peptide predicted for EAM_1533 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.994 between residues 31 and 32 716540007715 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540007716 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 716540007717 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 716540007718 HMMPfam hit to PF01118, Semialdehyde dehydrogenase, NAD bindin, score 4.8e-15 716540007719 fumarate hydratase; Provisional; Region: PRK15389 716540007720 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 716540007721 Fumarase C-terminus; Region: Fumerase_C; pfam05683 716540007722 HMMPfam hit to PF05683, Fumarase C-terminus, score 1.8e-115 716540007723 PS00163 Fumarate lyases signature. 716540007724 HMMPfam hit to PF05681, Fumarate hydratase (Fumerase), score 6e-137 716540007725 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 716540007726 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 716540007727 transmembrane helices; other site 716540007728 HMMPfam hit to PF00939, Sodium:sulfate symporter transmembrane, score 4.5e-211 716540007729 12 transmembrane helices predicted for EAM_1538 by TMHMM2.0 at aa 25-44, 49-66, 69-91, 111-133, 209-231, 251-273, 305-324, 328-345, 358-380, 395-417, 438-460 and 480-502 716540007730 HMMPfam hit to PF06808, DctM-like transporters, score 0.0014 716540007731 Signal peptide predicted for EAM_1538 by SignalP 2.0 HMM (Signal peptide probability 0.773) with cleavage site probability 0.694 between residues 45 and 46 716540007732 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 716540007733 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 716540007734 putative active site [active] 716540007735 putative FMN binding site [chemical binding]; other site 716540007736 putative substrate binding site [chemical binding]; other site 716540007737 putative catalytic residue [active] 716540007738 FMN-binding domain; Region: FMN_bind; cl01081 716540007739 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 716540007740 L-aspartate oxidase; Provisional; Region: PRK06175 716540007741 HMMPfam hit to PF00724, NADH:flavin oxidoreductase / NADH oxida, score 2.1e-81 716540007742 HMMPfam hit to PF03486, HI0933-like protein, score 0.00015 716540007743 HMMPfam hit to PF01134, Glucose inhibited division protein A, score 0.0021 716540007744 HMMPfam hit to PF00890, FAD binding domain, score 5.1e-103 716540007745 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidored, score 0.00026 716540007746 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 1e-06 716540007747 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 716540007748 ApbE family; Region: ApbE; pfam02424 716540007749 HMMPfam hit to PF02424, ApbE family, score 8.5e-53 716540007750 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 716540007751 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716540007752 active site 716540007753 phosphorylation site [posttranslational modification] 716540007754 intermolecular recognition site; other site 716540007755 dimerization interface [polypeptide binding]; other site 716540007756 Predicted helix-turn-helix motif with score 1129.000, SD 3.03 at aa 179-200, sequence FSTDDLAAAVNISRVSCRKYLI 716540007757 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.9e-25 716540007758 sensory histidine kinase DcuS; Provisional; Region: PRK11086 716540007759 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716540007760 ATP binding site [chemical binding]; other site 716540007761 Mg2+ binding site [ion binding]; other site 716540007762 G-X-G motif; other site 716540007763 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 1.8e-27 716540007764 HMMPfam hit to PF00989, PAS fold, score 1.2e-05 716540007765 2 transmembrane helices predicted for EAM_1542 by TMHMM2.0 at aa 20-42 and 183-202 716540007766 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 716540007767 HMMPfam hit to PF06004, Bacterial protein of unknown function (DUF90, score 8.8e-25 716540007768 Signal peptide predicted for EAM_1543 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.611 between residues 27 and 28 716540007769 1 transmembrane helix predicted for EAM_1543 by TMHMM2.0 at aa 5-27 716540007770 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540007771 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 716540007772 HMMPfam hit to PF06004, Bacterial protein of unknown function (DUF90, score 1.4e-30 716540007773 Signal peptide predicted for EAM_1544 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.547 between residues 25 and 26 716540007774 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 716540007775 1 transmembrane helix predicted for EAM_1548 by TMHMM2.0 at aa 5-27 716540007776 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 716540007777 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 716540007778 DNA binding site [nucleotide binding] 716540007779 HMMPfam hit to PF00486, Transcriptional regulatory protein, C ter, score 2.5e-10 716540007780 1 transmembrane helix predicted for EAM_1549 by TMHMM2.0 at aa 170-192 716540007781 Type III secretion system 1 716540007782 Bacterial type III secretion apparatus protein (OrgA_MxiK); Region: OrgA_MxiK; cl09716 716540007783 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 716540007784 1 transmembrane helix predicted for EAM_1552 by TMHMM2.0 at aa 209-231 716540007785 HMMPfam hit to PF01514, Secretory protein of YscJ/FliF family, score 4.9e-34 716540007786 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540007787 Signal peptide predicted for EAM_1552 by SignalP 2.0 HMM (Signal peptide probability 0.806) with cleavage site probability 0.621 between residues 20 and 21 716540007788 Type III secretion needle MxiH like; Region: MxiH; cl09641 716540007789 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480 716540007790 type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327; cl12363 716540007791 1 transmembrane helix predicted for EAM_1555 by TMHMM2.0 at aa 155-177 716540007792 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 716540007793 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 1.5e-05 716540007794 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 716540007795 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 716540007796 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 716540007797 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 716540007798 Signal peptide predicted for EAM_1557 by SignalP 2.0 HMM (Signal peptide probability 0.786) with cleavage site probability 0.754 between residues 28 and 29 716540007799 HMMPfam hit to PF03958, Bacterial type II/III secretion system sho, score 2.9e-08 716540007800 HMMPfam hit to PF03958, Bacterial type II/III secretion system sho, score 1.1e-12 716540007801 HMMPfam hit to PF00263, Bacterial type II and III secretion system, score 3.1e-43 716540007802 HrpJ-like domain; Region: HrpJ; pfam07201 716540007803 type III secretion system regulator InvE; Provisional; Region: PRK15338 716540007804 HMMPfam hit to PF02523, InvE invasion protein, score 9.8e-07 716540007805 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 716540007806 type III secretion system protein InvA; Provisional; Region: PRK15337 716540007807 8 transmembrane helices predicted for EAM_1559 by TMHMM2.0 at aa 13-35, 40-62, 69-91, 106-128, 198-217, 232-254, 275-294 and 298-315 716540007808 HMMPfam hit to PF00771, FHIPEP family, score 1.4e-273 716540007809 PS00994 Bacterial export FHIPEP family signature. 716540007810 Invasion protein B family; Region: Invas_SpaK; cl04129 716540007811 HMMPfam hit to PF03519, Invasion protein B family, score 4.7e-10 716540007812 ATP synthase SpaL; Validated; Region: PRK08149 716540007813 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 716540007814 Walker A motif; other site 716540007815 ATP binding site [chemical binding]; other site 716540007816 Walker B motif; other site 716540007817 HMMPfam hit to PF00006, ATP synthase alpha/beta family, nucleotid, score 2.1e-113 716540007818 PS00017 ATP/GTP-binding site motif A (P-loop). 716540007819 PS00152 ATP synthase alpha and beta subunits signature. 716540007820 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 716540007821 HMMPfam hit to PF01052, Surface presentation of antigens (SPOA) prot, score 1.1e-11 716540007822 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 716540007823 Signal peptide predicted for EAM_1565 by SignalP 2.0 HMM (Signal peptide probability 0.844) with cleavage site probability 0.614 between residues 43 and 44 716540007824 4 transmembrane helices predicted for EAM_1565 by TMHMM2.0 at aa 7-29, 44-66, 161-183 and 193-215 716540007825 HMMPfam hit to PF00813, FliP family, score 1.5e-95 716540007826 PS01061 Flagella transport protein fliP family signature 2. 716540007827 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 716540007828 Signal peptide predicted for EAM_1566 by SignalP 2.0 HMM (Signal peptide probability 0.923) with cleavage site probability 0.801 between residues 26 and 27 716540007829 HMMPfam hit to PF01313, Bacterial export proteins, family, score 3.7e-24 716540007830 2 transmembrane helices predicted for EAM_1566 by TMHMM2.0 at aa 13-35 and 45-67 716540007831 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 716540007832 HMMPfam hit to PF01311, Bacterial export proteins, family, score 4e-37 716540007833 6 transmembrane helices predicted for EAM_1567 by TMHMM2.0 at aa 13-35, 42-64, 79-101, 128-150, 182-204 and 211-233 716540007834 type III secretion system protein SpaS; Validated; Region: PRK08156 716540007835 HMMPfam hit to PF01312, FlhB HrpN YscU SpaS Family, score 3.7e-84 716540007836 4 transmembrane helices predicted for EAM_1568 by TMHMM2.0 at aa 30-47, 75-97, 136-155 and 183-205 716540007837 chaperone protein SicA; Provisional; Region: PRK15331 716540007838 Tetratricopeptide repeat; Region: TPR_3; pfam07720 716540007839 Tetratricopeptide repeat; Region: TPR_3; pfam07720 716540007840 HMMPfam hit to PF07720, Tetratricopeptide repeat, score 5e-09 716540007841 HMMPfam hit to PF07720, Tetratricopeptide repeat, score 3.3e-08 716540007842 Secretion system effector C (SseC) like family; Region: SseC; pfam04888 716540007843 HMMPfam hit to PF03518, Salmonella/Shigella invasin protein B, score 1.1e-16 716540007844 2 transmembrane helices predicted for EAM_1570 by TMHMM2.0 at aa 372-394 and 461-483 716540007845 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 716540007846 Invasion plasmid antigen IpaD; Region: IpaD; cl05827 716540007847 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 716540007848 1 transmembrane helix predicted for EAM_1575 by TMHMM2.0 at aa 126-148 716540007849 PS00017 ATP/GTP-binding site motif A (P-loop). 716540007850 GTP-binding protein YchF; Reviewed; Region: PRK09601 716540007851 YchF GTPase; Region: YchF; cd01900 716540007852 G1 box; other site 716540007853 GTP/Mg2+ binding site [chemical binding]; other site 716540007854 Switch I region; other site 716540007855 G2 box; other site 716540007856 Switch II region; other site 716540007857 G3 box; other site 716540007858 G4 box; other site 716540007859 G5 box; other site 716540007860 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 716540007861 HMMPfam hit to PF06071, Protein of unknown function (DUF933), score 1.4e-59 716540007862 HMMPfam hit to PF01926, GTPase of unknown function, score 1.9e-33 716540007863 PS00017 ATP/GTP-binding site motif A (P-loop). 716540007864 PS00443 Glutamine amidotransferases class-II active site. 716540007865 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 716540007866 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 716540007867 Sulfate transporter family; Region: Sulfate_transp; pfam00916 716540007868 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 716540007869 Signal peptide predicted for EAM_1577 by SignalP 2.0 HMM (Signal peptide probability 0.631) with cleavage site probability 0.459 between residues 38 and 39 716540007870 HMMPfam hit to PF00860, Permease family, score 0.0018 716540007871 12 transmembrane helices predicted for EAM_1577 by TMHMM2.0 at aa 17-39, 43-60, 65-82, 86-108, 120-139, 143-160, 167-186, 218-240, 260-282, 292-309, 311-333 and 348-380 716540007872 HMMPfam hit to PF00916, Sulfate transporter family, score 1.3e-77 716540007873 HMMPfam hit to PF01740, STAS domain, score 0.00027 716540007874 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 716540007875 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 716540007876 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 716540007877 putative active site [active] 716540007878 catalytic residue [active] 716540007879 HMMPfam hit to PF01195, Peptidyl-tRNA hydrolase, score 5.3e-105 716540007880 PS01196 Peptidyl-tRNA hydrolase signature 2. 716540007881 Signal peptide predicted for EAM_1580 by SignalP 2.0 HMM (Signal peptide probability 0.779) with cleavage site probability 0.773 between residues 18 and 19 716540007882 hypothetical protein; Provisional; Region: PRK10692 716540007883 Signal peptide predicted for EAM_1581 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.857 between residues 28 and 29 716540007884 2 transmembrane helices predicted for EAM_1581 by TMHMM2.0 at aa 7-29 and 39-61 716540007885 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 716540007886 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 716540007887 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 716540007888 active site 716540007889 HMMPfam hit to PF00156, Phosphoribosyl transferase domain, score 3.7e-37 716540007890 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 716540007891 PS00114 Phosphoribosyl pyrophosphate synthetase signature. 716540007892 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 716540007893 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 716540007894 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 716540007895 HMMPfam hit to PF08544, GHMP kinases C terminal, score 9.8e-05 716540007896 HMMPfam hit to PF00288, GHMP kinases N terminal domain, score 1.4e-15 716540007897 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 716540007898 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 716540007899 HMMPfam hit to PF03550, Outer membrane lipoprotein LolB, score 2.5e-66 716540007900 Signal peptide predicted for EAM_1584 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.995 between residues 26 and 27 716540007901 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540007902 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 716540007903 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 716540007904 tRNA; other site 716540007905 putative tRNA binding site [nucleotide binding]; other site 716540007906 putative NADP binding site [chemical binding]; other site 716540007907 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 716540007908 HMMPfam hit to PF05201, Glutamyl-tRNAGlu reductase, N-terminal d, score 8.3e-84 716540007909 PS00747 Glutamyl-tRNA reductase signature. 716540007910 HMMPfam hit to PF01488, Shikimate / quinate 5-dehydrogenase, score 6e-69 716540007911 HMMPfam hit to PF00745, Glutamyl-tRNAGlu reductase, dimerisation, score 1.4e-31 716540007912 peptide chain release factor 1; Validated; Region: prfA; PRK00591 716540007913 This domain is found in peptide chain release factors; Region: PCRF; smart00937 716540007914 RF-1 domain; Region: RF-1; pfam00472 716540007915 HMMPfam hit to PF03462, PCRF domain, score 9.3e-72 716540007916 HMMPfam hit to PF00472, Peptidyl-tRNA hydrolase domain, score 7.5e-74 716540007917 PS00745 Prokaryotic-type class I peptide chain release factors signature. 716540007918 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 716540007919 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716540007920 S-adenosylmethionine binding site [chemical binding]; other site 716540007921 HMMPfam hit to PF05175, Methyltransferase small domain, score 7.6e-09 716540007922 PS00092 N-6 Adenine-specific DNA methylases signature. 716540007923 Invasion gene expression up-regulator, SirB; Region: SirB; cl01184 716540007924 3 transmembrane helices predicted for EAM_1588 by TMHMM2.0 at aa 12-30, 70-92 and 104-123 716540007925 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 716540007926 hypothetical protein; Provisional; Region: PRK10941 716540007927 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 716540007928 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 716540007929 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 716540007930 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 716540007931 HMMPfam hit to PF00793, DAHP synthetase I family, score 1.4e-120 716540007932 META domain; Region: META; cl01245 716540007933 Signal peptide predicted for EAM_1591 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.625 between residues 23 and 24 716540007934 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540007935 HMMPfam hit to PF03724, Domain of unknown function (306), score 2e-19 716540007936 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 716540007937 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 716540007938 11 transmembrane helices predicted for EAM_1592 by TMHMM2.0 at aa 16-33, 37-59, 72-94, 109-128, 135-157, 167-189, 221-243, 258-280, 289-311, 316-338 and 345-364 716540007939 HMMPfam hit to PF01699, Sodium/calcium exchanger protein, score 7.8e-11 716540007940 Signal peptide predicted for EAM_1592 by SignalP 2.0 HMM (Signal peptide probability 0.963) with cleavage site probability 0.397 between residues 62 and 63 716540007941 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 716540007942 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 716540007943 DNA binding site [nucleotide binding] 716540007944 domain linker motif; other site 716540007945 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 716540007946 dimerization interface [polypeptide binding]; other site 716540007947 ligand binding site [chemical binding]; other site 716540007948 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 2.3e-06 716540007949 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 1.3e-11 716540007950 Predicted helix-turn-helix motif with score 1793.000, SD 5.29 at aa 7-28, sequence ITINDIARLAGVSKSTASLVLN 716540007951 PS00356 Bacterial regulatory proteins, lacI family signature. 716540007952 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 716540007953 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 716540007954 substrate binding [chemical binding]; other site 716540007955 active site 716540007956 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 716540007957 PS00294 Prenyl group binding site (CAAX box). 716540007958 HMMPfam hit to PF08244, Glycosyl hydrolases family 32 C termi, score 5.5e-08 716540007959 HMMPfam hit to PF00251, Glycosyl hydrolases family 32 N termi, score 5.8e-163 716540007960 PS00609 Glycosyl hydrolases family 32 active site. 716540007961 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 716540007962 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 716540007963 active site turn [active] 716540007964 phosphorylation site [posttranslational modification] 716540007965 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 716540007966 10 transmembrane helices predicted for EAM_1596 by TMHMM2.0 at aa 108-130, 145-167, 174-196, 206-228, 248-270, 285-307, 328-350, 360-382, 395-417 and 427-449 716540007967 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 1.5e-65 716540007968 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 716540007969 HMMPfam hit to PF00367, phosphotransferase system, EIIB, score 2.1e-18 716540007970 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 716540007971 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 716540007972 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 716540007973 trimer interface; other site 716540007974 sugar binding site [chemical binding]; other site 716540007975 HMMPfam hit to PF02264, LamB porin, score 2.8e-170 716540007976 1 transmembrane helix predicted for EAM_1597 by TMHMM2.0 at aa 5-27 716540007977 Signal peptide predicted for EAM_1597 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.868 between residues 23 and 24 716540007978 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 716540007979 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 716540007980 putative substrate binding site [chemical binding]; other site 716540007981 putative ATP binding site [chemical binding]; other site 716540007982 HMMPfam hit to PF00294, pfkB family carbohydrate kinase, score 5e-78 716540007983 PS00584 pfkB family of carbohydrate kinases signature 2. 716540007984 PS00583 pfkB family of carbohydrate kinases signature 1. 716540007985 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 716540007986 putative active site pocket [active] 716540007987 dimerization interface [polypeptide binding]; other site 716540007988 putative catalytic residue [active] 716540007989 HMMPfam hit to PF04752, ChaC-like protein, score 2.3e-75 716540007990 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 716540007991 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 716540007992 phosphopeptide binding site; other site 716540007993 HMMPfam hit to PF00498, FHA domain, score 1.5e-09 716540007994 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 716540007995 Predicted helix-turn-helix motif with score 1197.000, SD 3.26 at aa 167-188, sequence LKWPEVARRFNPLQYTSYWWTN 716540007996 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 716540007997 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 716540007998 3 transmembrane helices predicted for EAM_1602 by TMHMM2.0 at aa 13-35, 50-72 and 465-487 716540007999 PS00017 ATP/GTP-binding site motif A (P-loop). 716540008000 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 716540008001 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 716540008002 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 716540008003 ligand binding site [chemical binding]; other site 716540008004 HMMPfam hit to PF00691, OmpA family, score 4.2e-05 716540008005 putative invasin; Provisional; Region: PRK10177 716540008006 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 716540008007 Signal peptide predicted for EAM_1604 by SignalP 2.0 HMM (Signal peptide probability 0.873) with cleavage site probability 0.443 between residues 30 and 31 716540008008 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 716540008009 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 716540008010 trimer interface [polypeptide binding]; other site 716540008011 eyelet of channel; other site 716540008012 HMMPfam hit to PF00267, Gram-negative porin, score 3.4e-147 716540008013 Signal peptide predicted for EAM_1605 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.992 between residues 22 and 23 716540008014 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 716540008015 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 716540008016 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 716540008017 catalytic residue [active] 716540008018 HMMPfam hit to PF00202, Aminotransferase class-III, score 2.2e-11 716540008019 arginine succinyltransferase; Provisional; Region: PRK10456 716540008020 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 716540008021 HMMPfam hit to PF04958, Arginine N-succinyltransferase beta subunit, score 2.1e-190 716540008022 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 716540008023 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 716540008024 NAD(P) binding site [chemical binding]; other site 716540008025 catalytic residues [active] 716540008026 HMMPfam hit to PF00171, Aldehyde dehydrogenase family, score 3.1e-122 716540008027 PS00687 Aldehyde dehydrogenases glutamic acid active site. 716540008028 PS00070 Aldehyde dehydrogenases cysteine active site. 716540008029 succinylarginine dihydrolase; Provisional; Region: PRK13281 716540008030 HMMPfam hit to PF04996, Succinylarginine dihydrolase, score 1.3e-279 716540008031 succinylglutamate desuccinylase; Provisional; Region: PRK05324 716540008032 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 716540008033 active site 716540008034 Zn binding site [ion binding]; other site 716540008035 HMMPfam hit to PF04952, Succinylglutamate desuccinylase / Aspartoac, score 2.4e-74 716540008036 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 716540008037 dimer interface [polypeptide binding]; other site 716540008038 Signal peptide predicted for EAM_1612 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.982 between residues 23 and 24 716540008039 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 716540008040 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 716540008041 GIY-YIG motif/motif A; other site 716540008042 active site 716540008043 catalytic site [active] 716540008044 putative DNA binding site [nucleotide binding]; other site 716540008045 metal binding site [ion binding]; metal-binding site 716540008046 HMMPfam hit to PF01541, GIY-YIG catalytic domain, score 1.4e-14 716540008047 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 716540008048 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 716540008049 homodimer interface [polypeptide binding]; other site 716540008050 NAD binding pocket [chemical binding]; other site 716540008051 ATP binding pocket [chemical binding]; other site 716540008052 Mg binding site [ion binding]; other site 716540008053 active-site loop [active] 716540008054 HMMPfam hit to PF02540, NAD synthase, score 7.9e-116 716540008055 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 716540008056 HMMPfam hit to PF00083, Sugar (and other) transporter, score 0.00025 716540008057 12 transmembrane helices predicted for EAM_1615 by TMHMM2.0 at aa 9-31, 46-68, 75-97, 101-123, 135-157, 161-183, 218-240, 255-277, 284-306, 310-332, 339-358 and 368-390 716540008058 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 9.1e-47 716540008059 Signal peptide predicted for EAM_1615 by SignalP 2.0 HMM (Signal peptide probability 0.814) with cleavage site probability 0.756 between residues 37 and 38 716540008060 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 716540008061 Signal peptide predicted for EAM_1616 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.702 between residues 26 and 27 716540008062 1 transmembrane helix predicted for EAM_1616 by TMHMM2.0 at aa 4-23 716540008063 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540008064 HMMPfam hit to PF04355, SmpA / OmlA family, score 3.3e-09 716540008065 2 transmembrane helices predicted for EAM_1617 by TMHMM2.0 at aa 5-24 and 56-78 716540008066 Signal peptide predicted for EAM_1617 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.742 between residues 21 and 22 716540008067 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 716540008068 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 716540008069 HMMPfam hit to PF00375, Sodium:dicarboxylate symporter family, score 1.5e-100 716540008070 9 transmembrane helices predicted for EAM_1618 by TMHMM2.0 at aa 5-20, 32-50, 70-92, 105-127, 185-204, 225-244, 259-281, 370-389 and 394-416 716540008071 Signal peptide predicted for EAM_1618 by SignalP 2.0 HMM (Signal peptide probability 0.953) with cleavage site probability 0.479 between residues 20 and 21 716540008072 inner membrane protein; Provisional; Region: PRK11648 716540008073 HMMPfam hit to PF04307, Predicted membrane-bound metal-dependent hyd, score 2.5e-31 716540008074 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 716540008075 YniB-like protein; Region: YniB; pfam14002 716540008076 4 transmembrane helices predicted for EAM_1621 by TMHMM2.0 at aa 15-36, 53-72, 87-106 and 150-172 716540008077 Phosphotransferase enzyme family; Region: APH; pfam01636 716540008078 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 716540008079 active site 716540008080 ATP binding site [chemical binding]; other site 716540008081 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 716540008082 HMMPfam hit to PF03881, Fructosamine kinase, score 1.2e-156 716540008083 HMMPfam hit to PF01636, Phosphotransferase enzyme family, score 9.6e-33 716540008084 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 716540008085 Protein of unknown function, DUF481; Region: DUF481; cl01213 716540008086 Signal peptide predicted for EAM_1624 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 24 and 25 716540008087 HMMPfam hit to PF04338, Protein of unknown function, DUF481, score 7e-86 716540008088 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 716540008089 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 716540008090 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 716540008091 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 716540008092 active site 716540008093 dimer interface [polypeptide binding]; other site 716540008094 motif 1; other site 716540008095 motif 2; other site 716540008096 motif 3; other site 716540008097 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 716540008098 anticodon binding site; other site 716540008099 HMMPfam hit to PF02824, TGS domain, score 1.4e-13 716540008100 HMMPfam hit to PF07973, Threonyl and Alanyl tRNA synthetase se, score 1.8e-23 716540008101 HMMPfam hit to PF00587, tRNA synthetase class II core domain (, score 2.2e-64 716540008102 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 716540008103 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 716540008104 HMMPfam hit to PF03129, Anticodon binding domain, score 3e-32 716540008105 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 716540008106 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 716540008107 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 716540008108 HMMPfam hit to PF05198, Translation initiation factor IF-3, N-termin, score 3.2e-48 716540008109 PS00938 Initiation factor 3 signature. 716540008110 HMMPfam hit to PF00707, Translation initiation factor IF-3, C-termin, score 4.4e-54 716540008111 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 716540008112 HMMPfam hit to PF01632, Ribosomal protein L35, score 1.3e-34 716540008113 PS00936 Ribosomal protein L35 signature. 716540008114 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 716540008115 23S rRNA binding site [nucleotide binding]; other site 716540008116 L21 binding site [polypeptide binding]; other site 716540008117 L13 binding site [polypeptide binding]; other site 716540008118 HMMPfam hit to PF00453, Ribosomal protein L20, score 4.1e-68 716540008119 PS00937 Ribosomal protein L20 signature. 716540008120 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 716540008121 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 716540008122 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 716540008123 dimer interface [polypeptide binding]; other site 716540008124 motif 1; other site 716540008125 active site 716540008126 motif 2; other site 716540008127 motif 3; other site 716540008128 Signal peptide predicted for EAM_1631 by SignalP 2.0 HMM (Signal peptide probability 0.772) with cleavage site probability 0.697 between residues 18 and 19 716540008129 HMMPfam hit to PF02912, Aminoacyl tRNA synthetase class II, N, score 4e-36 716540008130 HMMPfam hit to PF01409, tRNA synthetases class II core domain, score 6.1e-168 716540008131 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 716540008132 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 716540008133 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 716540008134 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 716540008135 putative tRNA-binding site [nucleotide binding]; other site 716540008136 B3/4 domain; Region: B3_4; pfam03483 716540008137 tRNA synthetase B5 domain; Region: B5; smart00874 716540008138 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 716540008139 dimer interface [polypeptide binding]; other site 716540008140 motif 1; other site 716540008141 motif 3; other site 716540008142 motif 2; other site 716540008143 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 716540008144 HMMPfam hit to PF01588, tRNA binding domain, score 7.2e-40 716540008145 HMMPfam hit to PF03483, B3/4 domain, score 4.9e-110 716540008146 HMMPfam hit to PF03484, tRNA synthetase B5 domain, score 1.2e-29 716540008147 HMMPfam hit to PF03147, Ferredoxin-fold anticodon binding domain, score 3e-44 716540008148 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 716540008149 IHF dimer interface [polypeptide binding]; other site 716540008150 IHF - DNA interface [nucleotide binding]; other site 716540008151 HMMPfam hit to PF00216, Bacterial DNA-binding protein, score 1.2e-46 716540008152 PS00045 Bacterial histone-like DNA-binding proteins signature. 716540008153 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 716540008154 catalytic residues [active] 716540008155 dimer interface [polypeptide binding]; other site 716540008156 HMMPfam hit to PF00255, Glutathione peroxidase, score 4.1e-53 716540008157 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 716540008158 NlpC/P60 family; Region: NLPC_P60; pfam00877 716540008159 Signal peptide predicted for EAM_1636 by SignalP 2.0 HMM (Signal peptide probability 0.983) with cleavage site probability 0.744 between residues 19 and 20 716540008160 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540008161 HMMPfam hit to PF00877, NlpC/P60 family, score 7.2e-45 716540008162 1 transmembrane helix predicted for EAM_1637 by TMHMM2.0 at aa 37-59 716540008163 Uncharacterized conserved protein [Function unknown]; Region: COG0397 716540008164 hypothetical protein; Validated; Region: PRK00029 716540008165 HMMPfam hit to PF02696, Uncharacterized ACR, YdiU/UPF0061 family, score 2.4e-190 716540008166 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 716540008167 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 716540008168 Walker A/P-loop; other site 716540008169 ATP binding site [chemical binding]; other site 716540008170 Q-loop/lid; other site 716540008171 ABC transporter signature motif; other site 716540008172 Walker B; other site 716540008173 D-loop; other site 716540008174 H-loop/switch region; other site 716540008175 HMMPfam hit to PF00005, ABC transporter, score 8e-42 716540008176 PS00211 ABC transporters family signature. 716540008177 PS00017 ATP/GTP-binding site motif A (P-loop). 716540008178 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 716540008179 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 716540008180 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 716540008181 ABC-ATPase subunit interface; other site 716540008182 dimer interface [polypeptide binding]; other site 716540008183 putative PBP binding regions; other site 716540008184 HMMPfam hit to PF01032, FecCD transport family, score 5.1e-128 716540008185 9 transmembrane helices predicted for EAM_1640 by TMHMM2.0 at aa 7-29, 58-80, 87-109, 114-136, 143-165, 185-207, 239-261, 276-293 and 306-325 716540008186 Signal peptide predicted for EAM_1640 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.340 between residues 29 and 30 716540008187 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 716540008188 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 716540008189 putative hemin binding site; other site 716540008190 HMMPfam hit to PF01497, Periplasmic binding protein, score 1.4e-36 716540008191 Signal peptide predicted for EAM_1641 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.972 between residues 19 and 20 716540008192 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 716540008193 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 716540008194 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 716540008195 HMMPfam hit to PF05171, Haemin-degrading family, score 4e-85 716540008196 PEP synthetase regulatory protein; Provisional; Region: PRK05339 716540008197 HMMPfam hit to PF03618, Domain of unknown function (DUF299), score 6.9e-141 716540008198 PS00017 ATP/GTP-binding site motif A (P-loop). 716540008199 phosphoenolpyruvate synthase; Validated; Region: PRK06464 716540008200 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 716540008201 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 716540008202 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 716540008203 HMMPfam hit to PF01326, Pyruvate phosphate dikinase, PEP/pyru, score 2.6e-157 716540008204 HMMPfam hit to PF00391, PEP-utilising enzyme, mobile domain, score 1.4e-44 716540008205 PS00370 PEP-utilizing enzymes phosphorylation site signature. 716540008206 HMMPfam hit to PF02896, PEP-utilising enzyme, TIM barrel doma, score 6.1e-54 716540008207 PS00742 PEP-utilizing enzymes signature 2. 716540008208 putative inner membrane protein; Provisional; Region: PRK10983 716540008209 Domain of unknown function DUF20; Region: UPF0118; pfam01594 716540008210 HMMPfam hit to PF01594, Domain of unknown function DUF20, score 3.2e-47 716540008211 9 transmembrane helices predicted for EAM_1647 by TMHMM2.0 at aa 13-30, 34-51, 64-86, 159-181, 202-224, 228-250, 252-271, 276-295 and 308-330 716540008212 Signal peptide predicted for EAM_1647 by SignalP 2.0 HMM (Signal peptide probability 0.899) with cleavage site probability 0.521 between residues 41 and 42 716540008213 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540008214 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 716540008215 FAD binding domain; Region: FAD_binding_4; pfam01565 716540008216 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 716540008217 HMMPfam hit to PF01565, FAD binding domain, score 1.2e-43 716540008218 PS00017 ATP/GTP-binding site motif A (P-loop). 716540008219 HMMPfam hit to PF02913, FAD linked oxidases, C-terminal domain, score 2.5e-68 716540008220 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 716540008221 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 716540008222 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 716540008223 HMMPfam hit to PF01521, Iron-sulphur cluster biosynthesis, score 8.3e-32 716540008224 PS01152 Hypothetical hesB/yadR/yfhF family signature. 716540008225 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 716540008226 putative ABC transporter; Region: ycf24; CHL00085 716540008227 HMMPfam hit to PF01458, Uncharacterized protein family (UPF0051), score 2.7e-141 716540008228 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 716540008229 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 716540008230 Walker A/P-loop; other site 716540008231 ATP binding site [chemical binding]; other site 716540008232 Q-loop/lid; other site 716540008233 ABC transporter signature motif; other site 716540008234 Walker B; other site 716540008235 D-loop; other site 716540008236 H-loop/switch region; other site 716540008237 HMMPfam hit to PF00005, ABC transporter, score 3e-30 716540008238 PS00017 ATP/GTP-binding site motif A (P-loop). 716540008239 PS00211 ABC transporters family signature. 716540008240 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 716540008241 FeS assembly protein SufD; Region: sufD; TIGR01981 716540008242 HMMPfam hit to PF01458, Uncharacterized protein family (UPF0051), score 1.5e-80 716540008243 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 716540008244 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 716540008245 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 716540008246 catalytic residue [active] 716540008247 HMMPfam hit to PF00266, Aminotransferase class-V, score 1.3e-221 716540008248 HMMPfam hit to PF01212, Beta-eliminating lyase, score 1.5e-05 716540008249 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 716540008250 cysteine desufuration protein SufE; Provisional; Region: PRK09296 716540008251 HMMPfam hit to PF02657, Fe-S metabolism associated domain, score 1.6e-55 716540008252 murein lipoprotein; Provisional; Region: PRK15396 716540008253 HMMPfam hit to PF04728, Repeated sequence found in lipoprotein LPP, score 0.013 716540008254 HMMPfam hit to PF04728, Repeated sequence found in lipoprotein LPP, score 0.015 716540008255 Signal peptide predicted for EAM_1656 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.923 between residues 25 and 26 716540008256 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540008257 pyruvate kinase; Provisional; Region: PRK09206 716540008258 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 716540008259 domain interfaces; other site 716540008260 active site 716540008261 HMMPfam hit to PF02887, Pyruvate kinase, alpha/beta domain, score 4.6e-27 716540008262 HMMPfam hit to PF00224, Pyruvate kinase, barrel domain, score 1.5e-210 716540008263 PS00110 Pyruvate kinase active site signature. 716540008264 multidrug efflux protein; Reviewed; Region: PRK01766 716540008265 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 716540008266 cation binding site [ion binding]; other site 716540008267 12 transmembrane helices predicted for EAM_1658 by TMHMM2.0 at aa 12-34, 44-66, 91-113, 128-147, 160-182, 187-209, 241-263, 278-300, 313-335, 350-367, 387-409 and 419-438 716540008268 HMMPfam hit to PF01554, MatE, score 7.7e-50 716540008269 HMMPfam hit to PF01554, MatE, score 1.5e-41 716540008270 Signal peptide predicted for EAM_1658 by SignalP 2.0 HMM (Signal peptide probability 0.978) with cleavage site probability 0.555 between residues 41 and 42 716540008271 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 716540008272 Lumazine binding domain; Region: Lum_binding; pfam00677 716540008273 Lumazine binding domain; Region: Lum_binding; pfam00677 716540008274 HMMPfam hit to PF00677, Lumazine binding domain, score 8.4e-38 716540008275 PS00693 Riboflavin synthase alpha chain family signature. 716540008276 HMMPfam hit to PF00677, Lumazine binding domain, score 1.1e-37 716540008277 PS00693 Riboflavin synthase alpha chain family signature. 716540008278 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 716540008279 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716540008280 S-adenosylmethionine binding site [chemical binding]; other site 716540008281 HMMPfam hit to PF02353, Cyclopropane-fatty-acyl-phospholipid, score 1.1e-151 716540008282 HMMPfam hit to PF08241, Methyltransferase domain, score 1.7e-17 716540008283 HMMPfam hit to PF08242, Methyltransferase domain, score 4.9e-11 716540008284 putative transporter; Provisional; Region: PRK11043 716540008285 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540008286 putative substrate translocation pore; other site 716540008287 11 transmembrane helices predicted for EAM_1661 by TMHMM2.0 at aa 5-27, 42-64, 71-93, 97-119, 131-153, 158-177, 210-232, 271-290, 297-319, 334-356 and 363-380 716540008288 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.3e-53 716540008289 Signal peptide predicted for EAM_1661 by SignalP 2.0 HMM (Signal peptide probability 0.979) with cleavage site probability 0.405 between residues 32 and 33 716540008290 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 716540008291 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716540008292 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 716540008293 dimerization interface [polypeptide binding]; other site 716540008294 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 8e-19 716540008295 Predicted helix-turn-helix motif with score 1079.000, SD 2.86 at aa 17-38, sequence GSFTAAAAELHRVPSAISYTVR 716540008296 PS00044 Bacterial regulatory proteins, lysR family signature. 716540008297 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.1e-25 716540008298 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 716540008299 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 716540008300 DNA binding site [nucleotide binding] 716540008301 domain linker motif; other site 716540008302 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 716540008303 dimerization interface [polypeptide binding]; other site 716540008304 ligand binding site [chemical binding]; other site 716540008305 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 2.2e-29 716540008306 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 3.9e-12 716540008307 Predicted helix-turn-helix motif with score 2093.000, SD 6.32 at aa 2-23, sequence ATIKDVAKRAGVSTTTVSHVIN 716540008308 PS00356 Bacterial regulatory proteins, lacI family signature. 716540008309 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 716540008310 NlpC/P60 family; Region: NLPC_P60; pfam00877 716540008311 HMMPfam hit to PF00877, NlpC/P60 family, score 4.3e-49 716540008312 Signal peptide predicted for EAM_1664 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.994 between residues 25 and 26 716540008313 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 716540008314 putative GSH binding site [chemical binding]; other site 716540008315 catalytic residues [active] 716540008316 HMMPfam hit to PF00462, Glutaredoxin, score 2.4e-26 716540008317 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 716540008318 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 716540008319 dimer interface [polypeptide binding]; other site 716540008320 catalytic site [active] 716540008321 putative active site [active] 716540008322 putative substrate binding site [chemical binding]; other site 716540008323 HMMPfam hit to PF00929, Exonuclease, score 1.3e-33 716540008324 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 716540008325 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 716540008326 dimer interface [polypeptide binding]; other site 716540008327 active site 716540008328 metal binding site [ion binding]; metal-binding site 716540008329 glutathione binding site [chemical binding]; other site 716540008330 HMMPfam hit to PF00903, Glyoxalase/Bleomycin resistance protein/Di, score 1.4e-40 716540008331 PS00934 Glyoxalase I signature 1. 716540008332 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 716540008333 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 716540008334 FMN binding site [chemical binding]; other site 716540008335 active site 716540008336 substrate binding site [chemical binding]; other site 716540008337 catalytic residue [active] 716540008338 HMMPfam hit to PF00724, NADH:flavin oxidoreductase / NADH oxidas, score 1e-94 716540008339 putative metal dependent hydrolase; Provisional; Region: PRK11598 716540008340 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 716540008341 Sulfatase; Region: Sulfatase; pfam00884 716540008342 HMMPfam hit to PF00884, Sulfatase, score 2.8e-72 716540008343 HMMPfam hit to PF08019, Domain of unknown function (DUF1705), score 6.1e-70 716540008344 5 transmembrane helices predicted for EAM_1670 by TMHMM2.0 at aa 13-33, 48-70, 77-99, 119-141 and 153-175 716540008345 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 716540008346 HMMPfam hit to PF06945, Protein of unknown function (DUF1289), score 1.2e-18 716540008347 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 716540008348 Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442 716540008349 1 transmembrane helix predicted for EAM_1676 by TMHMM2.0 at aa 123-145 716540008350 transcriptional regulator SlyA; Provisional; Region: PRK03573 716540008351 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 716540008352 HMMPfam hit to PF01047, MarR family, score 4.4e-20 716540008353 Predicted helix-turn-helix motif with score 1097.000, SD 2.92 at aa 47-68, sequence QSQIQLAKAIGIEQPSLVRTLD 716540008354 PS01117 Bacterial regulatory proteins, marR family signature. 716540008355 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 716540008356 HMMPfam hit to PF05433, Rickettsia 17 kDa surface antigen, score 6.1e-10 716540008357 Signal peptide predicted for EAM_1678 by SignalP 2.0 HMM (Signal peptide probability 0.905) with cleavage site probability 0.388 between residues 23 and 24 716540008358 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540008359 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 716540008360 HMMPfam hit to PF03702, Uncharacterised protein family (UPF0075), score 4.8e-231 716540008361 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 716540008362 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 716540008363 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 716540008364 HMMPfam hit to PF01243, Pyridoxamine 5'-phosphate oxidase, score 5.9e-32 716540008365 PS01064 Pyridoxamine 5'-phosphate oxidase signature. 716540008366 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 716540008367 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 716540008368 active site 716540008369 HIGH motif; other site 716540008370 dimer interface [polypeptide binding]; other site 716540008371 KMSKS motif; other site 716540008372 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 716540008373 RNA binding surface [nucleotide binding]; other site 716540008374 HMMPfam hit to PF00579, tRNA synthetases class I (W and Y), score 3.5e-131 716540008375 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 716540008376 HMMPfam hit to PF01479, S4 domain, score 1.5e-07 716540008377 glutathionine S-transferase; Provisional; Region: PRK10542 716540008378 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 716540008379 C-terminal domain interface [polypeptide binding]; other site 716540008380 GSH binding site (G-site) [chemical binding]; other site 716540008381 dimer interface [polypeptide binding]; other site 716540008382 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 716540008383 dimer interface [polypeptide binding]; other site 716540008384 N-terminal domain interface [polypeptide binding]; other site 716540008385 substrate binding pocket (H-site) [chemical binding]; other site 716540008386 HMMPfam hit to PF00043, Glutathione S-transferase, C-terminal domain, score 4.4e-15 716540008387 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal domain, score 1.9e-08 716540008388 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 716540008389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540008390 putative substrate translocation pore; other site 716540008391 POT family; Region: PTR2; pfam00854 716540008392 14 transmembrane helices predicted for EAM_1684 by TMHMM2.0 at aa 21-43, 58-80, 89-106, 111-130, 151-173, 177-199, 220-239, 243-260, 273-295, 320-339, 352-373, 388-410, 417-439 and 459-481 716540008393 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 4.4e-16 716540008394 HMMPfam hit to PF00854, POT family, score 1.6e-98 716540008395 PS01023 PTR2 family proton/oligopeptide symporters signature 2. 716540008396 PS01022 PTR2 family proton/oligopeptide symporters signature 1. 716540008397 transcriptional regulator BetI; Validated; Region: PRK00767 716540008398 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 716540008399 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 716540008400 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 7.6e-12 716540008401 PS01081 Bacterial regulatory proteins, tetR family signature. 716540008402 Predicted helix-turn-helix motif with score 1330.000, SD 3.72 at aa 30-51, sequence ASLALIAKEAGVSTGIVSHYFG 716540008403 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 716540008404 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 716540008405 tetrameric interface [polypeptide binding]; other site 716540008406 NAD binding site [chemical binding]; other site 716540008407 catalytic residues [active] 716540008408 HMMPfam hit to PF00171, Aldehyde dehydrogenase family, score 7e-241 716540008409 PS00687 Aldehyde dehydrogenases glutamic acid active site. 716540008410 PS00070 Aldehyde dehydrogenases cysteine active site. 716540008411 choline dehydrogenase; Validated; Region: PRK02106 716540008412 lycopene cyclase; Region: lycopene_cycl; TIGR01789 716540008413 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 716540008414 HMMPfam hit to PF00732, GMC oxidoreductase, score 1.1e-139 716540008415 PS00623 GMC oxidoreductases signature 1. 716540008416 PS00624 GMC oxidoreductases signature 2. 716540008417 HMMPfam hit to PF05199, GMC oxidoreductase, score 2.9e-71 716540008418 endonuclease III; Provisional; Region: PRK10702 716540008419 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 716540008420 minor groove reading motif; other site 716540008421 helix-hairpin-helix signature motif; other site 716540008422 substrate binding pocket [chemical binding]; other site 716540008423 active site 716540008424 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 716540008425 PS00764 Endonuclease III iron-sulfur binding region signature. 716540008426 HMMPfam hit to PF00730, HhH-GPD superfamily base excision DNA repair, score 4.5e-20 716540008427 PS01155 Endonuclease III family signature. 716540008428 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 1.2e-06 716540008429 electron transport complex RsxE subunit; Provisional; Region: PRK12405 716540008430 5 transmembrane helices predicted for EAM_1689 by TMHMM2.0 at aa 27-49, 69-87, 91-113, 126-148 and 184-206 716540008431 HMMPfam hit to PF02508, Rnf-Nqr subunit, membrane protein, score 1.8e-108 716540008432 Signal peptide predicted for EAM_1689 by SignalP 2.0 HMM (Signal peptide probability 0.748) with cleavage site probability 0.355 between residues 38 and 39 716540008433 electron transport complex protein RnfG; Validated; Region: PRK01908 716540008434 HMMPfam hit to PF04205, FMN-binding domain, score 7e-26 716540008435 1 transmembrane helix predicted for EAM_1690 by TMHMM2.0 at aa 10-29 716540008436 Signal peptide predicted for EAM_1690 by SignalP 2.0 HMM (Signal peptide probability 0.917) with cleavage site probability 0.489 between residues 28 and 29 716540008437 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 716540008438 HMMPfam hit to PF03116, NQR2, RnfD, RnfE family, score 3.1e-166 716540008439 8 transmembrane helices predicted for EAM_1691 by TMHMM2.0 at aa 20-39, 44-64, 85-107, 214-236, 243-262, 266-288, 301-318 and 323-342 716540008440 Signal peptide predicted for EAM_1691 by SignalP 2.0 HMM (Signal peptide probability 0.975) with cleavage site probability 0.763 between residues 34 and 35 716540008441 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 716540008442 SLBB domain; Region: SLBB; pfam10531 716540008443 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.00031 716540008444 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 716540008445 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 716540008446 HMMPfam hit to PF01512, Respiratory-chain NADH dehydrogenase, score 3.2e-82 716540008447 electron transport complex protein RnfB; Provisional; Region: PRK05113 716540008448 Putative Fe-S cluster; Region: FeS; cl17515 716540008449 4Fe-4S binding domain; Region: Fer4; cl02805 716540008450 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 6.2e-05 716540008451 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 716540008452 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 4.5e-07 716540008453 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 716540008454 HMMPfam hit to PF04060, Fe-S cluster, score 4.3e-13 716540008455 Signal peptide predicted for EAM_1693 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.922 between residues 30 and 31 716540008456 1 transmembrane helix predicted for EAM_1693 by TMHMM2.0 at aa 4-26 716540008457 electron transport complex protein RsxA; Provisional; Region: PRK05151 716540008458 HMMPfam hit to PF02508, Rnf-Nqr subunit, membrane protein, score 4.2e-107 716540008459 6 transmembrane helices predicted for EAM_1694 by TMHMM2.0 at aa 5-27, 42-64, 69-88, 103-125, 132-154 and 169-191 716540008460 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 716540008461 4 transmembrane helices predicted for EAM_1695 by TMHMM2.0 at aa 13-35, 55-77, 90-109 and 114-133 716540008462 Signal peptide predicted for EAM_1695 by SignalP 2.0 HMM (Signal peptide probability 0.687) with cleavage site probability 0.465 between residues 32 and 33 716540008463 L-arabinose isomerase; Provisional; Region: PRK02929 716540008464 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 716540008465 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 716540008466 trimer interface [polypeptide binding]; other site 716540008467 putative substrate binding site [chemical binding]; other site 716540008468 putative metal binding site [ion binding]; other site 716540008469 HMMPfam hit to PF02610, L-arabinose isomerase, score 0 716540008470 ribulokinase; Provisional; Region: PRK04123 716540008471 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 716540008472 N- and C-terminal domain interface [polypeptide binding]; other site 716540008473 active site 716540008474 MgATP binding site [chemical binding]; other site 716540008475 catalytic site [active] 716540008476 metal binding site [ion binding]; metal-binding site 716540008477 carbohydrate binding site [chemical binding]; other site 716540008478 homodimer interface [polypeptide binding]; other site 716540008479 HMMPfam hit to PF02782, FGGY family of carbohydrate kinases, C-termi, score 2.5e-06 716540008480 HMMPfam hit to PF00370, FGGY family of carbohydrate kinases, N-termi, score 1.4e-05 716540008481 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 716540008482 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 716540008483 ligand binding site [chemical binding]; other site 716540008484 Signal peptide predicted for EAM_1698 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.995 between residues 23 and 24 716540008485 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 1.3e-113 716540008486 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 716540008487 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 716540008488 Walker A/P-loop; other site 716540008489 ATP binding site [chemical binding]; other site 716540008490 Q-loop/lid; other site 716540008491 ABC transporter signature motif; other site 716540008492 Walker B; other site 716540008493 D-loop; other site 716540008494 H-loop/switch region; other site 716540008495 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 716540008496 HMMPfam hit to PF00005, ABC transporter, score 4.5e-61 716540008497 PS00017 ATP/GTP-binding site motif A (P-loop). 716540008498 PS00211 ABC transporters family signature. 716540008499 HMMPfam hit to PF00005, ABC transporter, score 1.7e-19 716540008500 PS00211 ABC transporters family signature. 716540008501 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 716540008502 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 716540008503 TM-ABC transporter signature motif; other site 716540008504 9 transmembrane helices predicted for EAM_1700 by TMHMM2.0 at aa 21-43, 53-72, 79-98, 102-124, 131-150, 170-192, 222-241, 256-288 and 295-317 716540008505 HMMPfam hit to PF02653, Branched-chain amino acid transport syst, score 3.2e-58 716540008506 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 716540008507 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 716540008508 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716540008509 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716540008510 HMMPfam hit to PF02311, AraC-like ligand binding domain, score 4.4e-24 716540008511 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix pr, score 5.4e-09 716540008512 Predicted helix-turn-helix motif with score 1598.000, SD 4.63 at aa 199-220, sequence VKIDQVARHVCLSPSRLAHLFR 716540008513 PS00041 Bacterial regulatory proteins, araC family signature. 716540008514 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix pr, score 3.4e-12 716540008515 putative oxidoreductase; Provisional; Region: PRK11579 716540008516 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 716540008517 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 716540008518 HMMPfam hit to PF01408, Oxidoreductase family, NAD-binding Ros, score 1.3e-33 716540008519 HMMPfam hit to PF01118, Semialdehyde dehydrogenase, NAD bindin, score 0.00065 716540008520 HMMPfam hit to PF02894, Oxidoreductase family, C-terminal alph, score 2.6e-23 716540008521 adenosine deaminase; Provisional; Region: PRK09358 716540008522 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 716540008523 active site 716540008524 HMMPfam hit to PF00962, Adenosine/AMP deaminase, score 9e-112 716540008525 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 716540008526 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 716540008527 HMMPfam hit to PF06097, Bacterial protein of unknown function (DUF94, score 2.4e-178 716540008528 PS00017 ATP/GTP-binding site motif A (P-loop). 716540008529 1 transmembrane helix predicted for EAM_1704 by TMHMM2.0 at aa 7-26 716540008530 Signal peptide predicted for EAM_1704 by SignalP 2.0 HMM (Signal peptide probability 0.967) with cleavage site probability 0.645 between residues 19 and 20 716540008531 fumarate hydratase; Reviewed; Region: fumC; PRK00485 716540008532 Class II fumarases; Region: Fumarase_classII; cd01362 716540008533 active site 716540008534 tetramer interface [polypeptide binding]; other site 716540008535 HMMPfam hit to PF00206, Lyase, score 3.5e-182 716540008536 PS00163 Fumarate lyases signature. 716540008537 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 716540008538 HMMPfam hit to PF05472, DNA replication terminus site-binding protei, score 1.3e-140 716540008539 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 716540008540 Signal peptide predicted for EAM_1707 by SignalP 2.0 HMM (Signal peptide probability 0.991) with cleavage site probability 0.922 between residues 37 and 38 716540008541 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540008542 HMMPfam hit to PF07313, Protein of unknown function (DUF1460), score 3e-126 716540008543 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540008544 Major Facilitator Superfamily; Region: MFS_1; pfam07690 716540008545 putative substrate translocation pore; other site 716540008546 12 transmembrane helices predicted for EAM_1708 by TMHMM2.0 at aa 40-59, 74-96, 108-130, 134-156, 163-185, 195-217, 246-268, 278-297, 310-332, 336-358, 370-389 and 393-415 716540008547 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.5e-43 716540008548 PS00216 Sugar transport proteins signature 1. 716540008549 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 716540008550 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716540008551 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 716540008552 dimerization interface [polypeptide binding]; other site 716540008553 substrate binding pocket [chemical binding]; other site 716540008554 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 8.4e-21 716540008555 Predicted helix-turn-helix motif with score 1496.000, SD 4.28 at aa 18-39, sequence LHFGRAALRLNISQPPLSQQIQ 716540008556 PS00044 Bacterial regulatory proteins, lysR family signature. 716540008557 HMMPfam hit to PF03466, LysR substrate binding domain, score 5.6e-51 716540008558 MarR family; Region: MarR_2; cl17246 716540008559 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 716540008560 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 716540008561 Predicted helix-turn-helix motif with score 1334.000, SD 3.73 at aa 31-52, sequence VSRIDLSKKASLSPASITKIVR 716540008562 HMMPfam hit to PF00480, ROK family, score 1.5e-27 716540008563 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 716540008564 AAA domain; Region: AAA_26; pfam13500 716540008565 HMMPfam hit to PF01656, CobQ/CobB/MinD/ParA nucleotide binding domai, score 1.2e-21 716540008566 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 716540008567 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540008568 putative substrate translocation pore; other site 716540008569 Signal peptide predicted for EAM_1712 by SignalP 2.0 HMM (Signal peptide probability 0.977) with cleavage site probability 0.575 between residues 32 and 33 716540008570 14 transmembrane helices predicted for EAM_1712 by TMHMM2.0 at aa 9-31, 46-68, 75-97, 101-123, 136-158, 162-184, 197-216, 221-240, 261-283, 293-315, 322-344, 354-376, 397-419 and 453-475 716540008571 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 5.7e-60 716540008572 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 716540008573 HMMPfam hit to PF06649, Protein of unknown function (DUF1161), score 4.4e-32 716540008574 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540008575 Signal peptide predicted for EAM_1713 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.616 between residues 22 and 23 716540008576 hypothetical protein; Provisional; Region: PRK13659 716540008577 HMMPfam hit to PF06932, Protein of unknown function (DUF1283), score 8.5e-51 716540008578 Signal peptide predicted for EAM_1714 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 30 and 31 716540008579 malonic semialdehyde reductase; Provisional; Region: PRK10538 716540008580 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 716540008581 putative NAD(P) binding site [chemical binding]; other site 716540008582 homodimer interface [polypeptide binding]; other site 716540008583 homotetramer interface [polypeptide binding]; other site 716540008584 active site 716540008585 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase family, score 0.00018 716540008586 HMMPfam hit to PF00106, short chain dehydrogenase, score 3.1e-30 716540008587 PS00061 Short-chain dehydrogenases/reductases family signature. 716540008588 guanine deaminase; Provisional; Region: PRK09228 716540008589 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 716540008590 active site 716540008591 HMMPfam hit to PF01979, Amidohydrolase family, score 4.1e-67 716540008592 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 716540008593 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 716540008594 active site 716540008595 Zn binding site [ion binding]; other site 716540008596 HMMPfam hit to PF01432, Peptidase family M3, score 9.7e-165 716540008597 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 716540008598 hypothetical protein; Provisional; Region: PRK06847 716540008599 hypothetical protein; Provisional; Region: PRK07236 716540008600 HMMPfam hit to PF01494, FAD binding domain, score 1.1e-08 716540008601 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 716540008602 Predicted membrane protein [Function unknown]; Region: COG2707 716540008603 HMMPfam hit to PF04284, Protein of unknown function (DUF441), score 1.2e-68 716540008604 Signal peptide predicted for EAM_1721 by SignalP 2.0 HMM (Signal peptide probability 0.988) with cleavage site probability 0.341 between residues 21 and 22 716540008605 4 transmembrane helices predicted for EAM_1721 by TMHMM2.0 at aa 10-32, 52-71, 86-105 and 112-134 716540008606 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 716540008607 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 716540008608 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 716540008609 NAD(P) binding site [chemical binding]; other site 716540008610 HMMPfam hit to PF00208, Glutamate/Leucine/Phenylalanine/Valin, score 2.3e-105 716540008611 PS00137 Serine proteases, subtilase family, histidine active site. 716540008612 HMMPfam hit to PF02812, Glu/Leu/Phe/Val dehydrogenase, dimeri, score 8.8e-66 716540008613 PS00074 Glu / Leu / Phe / Val dehydrogenases active site. 716540008614 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 716540008615 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 716540008616 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 716540008617 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 716540008618 HMMPfam hit to PF07055, Short-chain alcohol dehydrogenase, score 7.4e-282 716540008619 PS00017 ATP/GTP-binding site motif A (P-loop). 716540008620 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 716540008621 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 716540008622 N-terminal plug; other site 716540008623 ligand-binding site [chemical binding]; other site 716540008624 Signal peptide predicted for EAM_1726 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.991 between residues 32 and 33 716540008625 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 9e-14 716540008626 HMMPfam hit to PF00593, TonB dependent receptor, score 9.6e-27 716540008627 Rdx family; Region: Rdx; cl01407 716540008628 HMMPfam hit to PF05169, Selenoprotein W-related family, score 1.5e-45 716540008629 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 716540008630 HMMPfam hit to PF07077, Protein of unknown function (DUF1345), score 2.2e-64 716540008631 6 transmembrane helices predicted for EAM_1728 by TMHMM2.0 at aa 15-34, 41-60, 80-102, 115-137, 163-185 and 198-220 716540008632 Signal peptide predicted for EAM_1728 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.969 between residues 38 and 39 716540008633 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 716540008634 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 716540008635 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 716540008636 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 1.3e-20 716540008637 Predicted helix-turn-helix motif with score 1711.000, SD 5.01 at aa 28-49, sequence ASMNELAKRLGGSKGTLYNYFP 716540008638 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 716540008639 Signal peptide predicted for EAM_1730 by SignalP 2.0 HMM (Signal peptide probability 0.978) with cleavage site probability 0.465 between residues 31 and 32 716540008640 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540008641 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 716540008642 active site 716540008643 catalytic site [active] 716540008644 putative metal binding site [ion binding]; other site 716540008645 HMMPfam hit to PF00388, Phosphatidylinositol-specific phospholipase, score 1.9e-11 716540008646 lipoprotein; Provisional; Region: PRK10540 716540008647 Signal peptide predicted for EAM_1733 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.928 between residues 21 and 22 716540008648 2 transmembrane helices predicted for EAM_1733 by TMHMM2.0 at aa 7-26 and 41-63 716540008649 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540008650 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 716540008651 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 716540008652 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716540008653 Coenzyme A binding pocket [chemical binding]; other site 716540008654 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 4e-09 716540008655 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 716540008656 Signal peptide predicted for EAM_1735 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.807 between residues 21 and 22 716540008657 HMMPfam hit to PF03767, HAD superfamily, subfamily IIIB (Acid, score 5e-38 716540008658 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540008659 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 716540008660 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 716540008661 tetramer interface [polypeptide binding]; other site 716540008662 heme binding pocket [chemical binding]; other site 716540008663 NADPH binding site [chemical binding]; other site 716540008664 HMMPfam hit to PF00199, Catalase, score 9.4e-258 716540008665 PS00437 Catalase proximal heme-ligand signature. 716540008666 PS00438 Catalase proximal active site signature. 716540008667 Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910 716540008668 HMMPfam hit to PF02604, Phd_YefM, score 3.3e-08 716540008669 Fic/DOC family; Region: Fic; cl00960 716540008670 HMMPfam hit to PF05012, Prophage maintenance system killer protein, score 6.4e-35 716540008671 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 716540008672 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 716540008673 dimer interface [polypeptide binding]; other site 716540008674 putative CheW interface [polypeptide binding]; other site 716540008675 Signal peptide predicted for EAM_1741 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.567 between residues 31 and 32 716540008676 2 transmembrane helices predicted for EAM_1741 by TMHMM2.0 at aa 15-33 and 320-342 716540008677 HMMPfam hit to PF00672, HAMP domain, score 1e-13 716540008678 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 5.6e-69 716540008679 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 716540008680 active site clefts [active] 716540008681 zinc binding site [ion binding]; other site 716540008682 dimer interface [polypeptide binding]; other site 716540008683 HMMPfam hit to PF00484, Carbonic anhydrase, score 2.1e-74 716540008684 PS00704 Prokaryotic-type carbonic anhydrases signature 1. 716540008685 PS00705 Prokaryotic-type carbonic anhydrases signature 2. 716540008686 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 716540008687 malate:quinone oxidoreductase; Validated; Region: PRK05257 716540008688 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 716540008689 Signal peptide predicted for EAM_1744 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 24 and 25 716540008690 HMMPfam hit to PF06039, Malate:quinone oxidoreductase (Mqo), score 0 716540008691 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 0.00016 716540008692 Signal peptide predicted for EAM_1745 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.354 between residues 22 and 23 716540008693 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540008694 Virulence factor SrfB; Region: SrfB; pfam07520 716540008695 HMMPfam hit to PF07520, Virulence factor SrfB, score 0 716540008696 PS00017 ATP/GTP-binding site motif A (P-loop). 716540008697 Putative bacterial virulence factor; Region: Virul_Fac; pfam10139 716540008698 PS00017 ATP/GTP-binding site motif A (P-loop). 716540008699 hypothetical protein; Provisional; Region: PRK07190 716540008700 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 716540008701 HMMPfam hit to PF01494, FAD binding domain, score 4.6e-38 716540008702 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 716540008703 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 716540008704 substrate binding pocket [chemical binding]; other site 716540008705 active site 716540008706 iron coordination sites [ion binding]; other site 716540008707 HMMPfam hit to PF02668, Taurine catabolism dioxygenase TauD, TfdA fa, score 1.9e-56 716540008708 Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141 716540008709 HMMPfam hit to PF05141, Pyoverdine/dityrosine biosynthesis protein, score 1.1e-101 716540008710 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 716540008711 RNAase interaction site [polypeptide binding]; other site 716540008712 HMMPfam hit to PF01337, Barstar (barnase inhibitor), score 0.00036 716540008713 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 716540008714 active site 716540008715 HMMPfam hit to PF00545, ribonuclease, score 3.6e-13 716540008716 Signal peptide predicted for EAM_1753 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.616 between residues 20 and 21 716540008717 Domain of unknown function DUF20; Region: UPF0118; pfam01594 716540008718 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 716540008719 8 transmembrane helices predicted for EAM_1754 by TMHMM2.0 at aa 9-28, 32-54, 61-83, 151-173, 207-226, 236-253, 258-280 and 307-329 716540008720 Rrf2 family protein; Region: rrf2_super; TIGR00738 716540008721 Transcriptional regulator; Region: Rrf2; pfam02082 716540008722 Transcriptional regulator; Region: Rrf2; cl17282 716540008723 HMMPfam hit to PF02082, Transcriptional regulator, score 4.3e-16 716540008724 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 716540008725 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716540008726 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 7.3e-11 716540008727 Predicted helix-turn-helix motif with score 1005.000, SD 2.61 at aa 22-43, sequence MDLDTVADRAGYSKWHLQRMFK 716540008728 PS00041 Bacterial regulatory proteins, araC family signature. 716540008729 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 9.6e-09 716540008730 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 716540008731 glutaminase; Provisional; Region: PRK00971 716540008732 HMMPfam hit to PF04960, Glutaminase, score 4.7e-178 716540008733 putative arabinose transporter; Provisional; Region: PRK03545 716540008734 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540008735 putative substrate translocation pore; other site 716540008736 Signal peptide predicted for EAM_1758 by SignalP 2.0 HMM (Signal peptide probability 0.792) with cleavage site probability 0.192 between residues 44 and 45 716540008737 12 transmembrane helices predicted for EAM_1758 by TMHMM2.0 at aa 13-35, 50-72, 79-99, 109-131, 138-160, 170-189, 210-232, 247-269, 276-295, 299-321, 334-356 and 360-382 716540008738 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.1e-40 716540008739 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 716540008740 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 716540008741 Flavin binding site [chemical binding]; other site 716540008742 HMMPfam hit to PF08028, Acyl-CoA dehydrogenase, C-terminal doma, score 0.00045 716540008743 3 transmembrane helices predicted for EAM_1760 by TMHMM2.0 at aa 20-42, 49-66 and 70-89 716540008744 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 716540008745 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 716540008746 active site 716540008747 non-prolyl cis peptide bond; other site 716540008748 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 716540008749 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 716540008750 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidoreduc, score 0.00037 716540008751 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 0.00029 716540008752 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 716540008753 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 716540008754 active site 716540008755 dimer interface [polypeptide binding]; other site 716540008756 non-prolyl cis peptide bond; other site 716540008757 insertion regions; other site 716540008758 HMMPfam hit to PF00296, Luciferase-like monooxygenase, score 6e-05 716540008759 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 716540008760 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 716540008761 active site 716540008762 dimer interface [polypeptide binding]; other site 716540008763 non-prolyl cis peptide bond; other site 716540008764 insertion regions; other site 716540008765 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 716540008766 HMMPfam hit to PF00296, Luciferase-like monooxygenase, score 3.2e-05 716540008767 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 716540008768 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716540008769 Walker A motif; other site 716540008770 ATP binding site [chemical binding]; other site 716540008771 Walker B motif; other site 716540008772 arginine finger; other site 716540008773 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 716540008774 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 716540008775 substrate binding pocket [chemical binding]; other site 716540008776 membrane-bound complex binding site; other site 716540008777 hinge residues; other site 716540008778 HMMPfam hit to PF00158, Sigma-54 interaction domain, score 5.3e-143 716540008779 HMMPfam hit to PF07728, ATPase family associated with various, score 0.00047 716540008780 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 716540008781 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 716540008782 PS00688 Sigma-54 interaction domain C-terminal part signature. 716540008783 Predicted helix-turn-helix motif with score 1449.000, SD 4.12 at aa 298-319, sequence GNQLQAAALLGISRHTLRTHLG 716540008784 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 716540008785 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 716540008786 peptide binding site [polypeptide binding]; other site 716540008787 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 3.2e-91 716540008788 Signal peptide predicted for EAM_1766 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 23 and 24 716540008789 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 716540008790 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 716540008791 metal binding site [ion binding]; metal-binding site 716540008792 dimer interface [polypeptide binding]; other site 716540008793 HMMPfam hit to PF05343, M42 glutamyl aminopeptidase, score 0.00034 716540008794 PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 716540008795 HMMPfam hit to PF01546, Peptidase family M20/M25/M40, score 0.00018 716540008796 PS00759 ArgE / dapE / ACY1 / CPG2 / yscS family signature 2. 716540008797 HMMPfam hit to PF07687, Peptidase dimerisation domain, score 6.9e-12 716540008798 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 716540008799 dimerization interface [polypeptide binding]; other site 716540008800 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 716540008801 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 716540008802 dimer interface [polypeptide binding]; other site 716540008803 putative CheW interface [polypeptide binding]; other site 716540008804 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 2.4e-106 716540008805 PS00538 Bacterial chemotaxis sensory transducers signature. 716540008806 HMMPfam hit to PF00672, HAMP domain, score 1.1e-06 716540008807 2 transmembrane helices predicted for EAM_1769 by TMHMM2.0 at aa 13-35 and 181-203 716540008808 Signal peptide predicted for EAM_1769 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.680 between residues 36 and 37 716540008809 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 716540008810 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 716540008811 substrate binding pocket [chemical binding]; other site 716540008812 catalytic triad [active] 716540008813 HMMPfam hit to PF00135, Carboxylesterase, score 8.1e-104 716540008814 PS00122 Carboxylesterases type-B serine active site. 716540008815 PS00941 Carboxylesterases type-B signature 2. 716540008816 benzoate transport; Region: 2A0115; TIGR00895 716540008817 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540008818 putative substrate translocation pore; other site 716540008819 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540008820 putative substrate translocation pore; other site 716540008821 HMMPfam hit to PF00083, Sugar (and other) transporter, score 2.1e-06 716540008822 10 transmembrane helices predicted for EAM_1771 by TMHMM2.0 at aa 24-46, 61-83, 90-112, 116-138, 150-172, 177-199, 254-276, 291-313, 320-342 and 409-431 716540008823 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 3e-48 716540008824 PS00217 Sugar transport proteins signature 2. 716540008825 PS00216 Sugar transport proteins signature 1. 716540008826 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 716540008827 Acyltransferase family; Region: Acyl_transf_3; pfam01757 716540008828 HMMPfam hit to PF01757, Acyltransferase family, score 4.2e-05 716540008829 10 transmembrane helices predicted for EAM_1772 by TMHMM2.0 at aa 5-27, 42-59, 80-102, 122-144, 151-173, 183-205, 212-234, 249-268, 281-300 and 313-335 716540008830 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 716540008831 Signal peptide predicted for EAM_1773 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.991 between residues 21 and 22 716540008832 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540008833 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 716540008834 Smr domain; Region: Smr; pfam01713 716540008835 HMMPfam hit to PF01713, Smr domain, score 5.6e-22 716540008836 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 716540008837 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 716540008838 ligand binding site [chemical binding]; other site 716540008839 flexible hinge region; other site 716540008840 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 716540008841 putative switch regulator; other site 716540008842 non-specific DNA interactions [nucleotide binding]; other site 716540008843 DNA binding site [nucleotide binding] 716540008844 sequence specific DNA binding site [nucleotide binding]; other site 716540008845 putative cAMP binding site [chemical binding]; other site 716540008846 HMMPfam hit to PF00027, Cyclic nucleotide-binding domain, score 1e-20 716540008847 HMMPfam hit to PF00325, Bacterial regulatory proteins, crp famil, score 5.7e-15 716540008848 PS00042 Bacterial regulatory proteins, crp family signature. 716540008849 Predicted helix-turn-helix motif with score 1941.000, SD 5.80 at aa 196-217, sequence MTRSDIGNYLGLTVETISRLLG 716540008850 universal stress protein UspE; Provisional; Region: PRK11175 716540008851 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 716540008852 Ligand Binding Site [chemical binding]; other site 716540008853 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 716540008854 Ligand Binding Site [chemical binding]; other site 716540008855 HMMPfam hit to PF00582, Universal stress protein family, score 5.2e-16 716540008856 HMMPfam hit to PF00582, Universal stress protein family, score 5.8e-11 716540008857 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 716540008858 Signal peptide predicted for EAM_1777 by SignalP 2.0 HMM (Signal peptide probability 0.703) with cleavage site probability 0.573 between residues 43 and 44 716540008859 2 transmembrane helices predicted for EAM_1777 by TMHMM2.0 at aa 24-46 and 117-139 716540008860 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 716540008861 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 716540008862 N-terminal plug; other site 716540008863 ligand-binding site [chemical binding]; other site 716540008864 Signal peptide predicted for EAM_1778 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.968 between residues 23 and 24 716540008865 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540008866 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 2.5e-13 716540008867 HMMPfam hit to PF00593, TonB dependent receptor, score 2.4e-22 716540008868 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 716540008869 Signal peptide predicted for EAM_1779 by SignalP 2.0 HMM (Signal peptide probability 0.700) with cleavage site probability 0.352 between residues 29 and 30 716540008870 2 transmembrane helices predicted for EAM_1779 by TMHMM2.0 at aa 13-35 and 57-79 716540008871 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 716540008872 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 716540008873 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 716540008874 HMMPfam hit to PF07338, Protein of unknown function (DUF1471), score 5.9e-10 716540008875 Signal peptide predicted for EAM_1781 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.990 between residues 22 and 23 716540008876 HMMPfam hit to PF07338, Protein of unknown function (DUF1471), score 3.4e-06 716540008877 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 716540008878 Signal peptide predicted for EAM_1782 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.419 between residues 34 and 35 716540008879 13 transmembrane helices predicted for EAM_1782 by TMHMM2.0 at aa 5-24, 39-61, 90-112, 127-149, 161-183, 203-222, 234-256, 276-298, 331-353, 358-380, 387-406, 410-428 and 440-462 716540008880 HMMPfam hit to PF00324, Amino acid permease, score 1.6e-05 716540008881 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 716540008882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716540008883 active site 716540008884 phosphorylation site [posttranslational modification] 716540008885 intermolecular recognition site; other site 716540008886 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 716540008887 DNA binding site [nucleotide binding] 716540008888 HMMPfam hit to PF00072, Response regulator receiver domain, score 3.8e-18 716540008889 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 9.1e-17 716540008890 YcfA-like protein; Region: YcfA; pfam07927 716540008891 HMMPfam hit to PF07927, YcfA-like protein, score 1.3e-20 716540008892 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 716540008893 HMMPfam hit to PF03681, Uncharacterised protein family (UPF0150), score 4.7e-16 716540008894 Acyltransferase family; Region: Acyl_transf_3; pfam01757 716540008895 HMMPfam hit to PF01757, Acyltransferase family, score 1.2e-24 716540008896 8 transmembrane helices predicted for EAM_1788 by TMHMM2.0 at aa 35-57, 78-95, 124-146, 151-168, 178-197, 204-223, 233-252 and 296-318 716540008897 HMMPfam hit to PF03335, Phage tail fibre repeat, score 0.76 716540008898 HMMPfam hit to PF03335, Phage tail fibre repeat, score 36 716540008899 HMMPfam hit to PF03335, Phage tail fibre repeat, score 12 716540008900 HMMPfam hit to PF03335, Phage tail fibre repeat, score 8.1 716540008901 B12 binding domain; Region: B12-binding_2; cl03653 716540008902 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 716540008903 active site 716540008904 substrate binding site [chemical binding]; other site 716540008905 trimer interface [polypeptide binding]; other site 716540008906 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 716540008907 CoA binding site [chemical binding]; other site 716540008908 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 21 716540008909 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 8.3 716540008910 PS00101 Hexapeptide-repeat containing-transferases signature. 716540008911 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.7 716540008912 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 716540008913 HMMPfam hit to PF03335, Phage tail fibre repeat, score 0.021 716540008914 HMMPfam hit to PF03335, Phage tail fibre repeat, score 29 716540008915 HMMPfam hit to PF03335, Phage tail fibre repeat, score 8.1 716540008916 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 716540008917 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 716540008918 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 716540008919 Int/Topo IB signature motif; other site 716540008920 HMMPfam hit to PF00589, Phage integrase family, score 1.4e-09 716540008921 sensor protein RstB; Provisional; Region: PRK10604 716540008922 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 716540008923 dimerization interface [polypeptide binding]; other site 716540008924 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 716540008925 dimer interface [polypeptide binding]; other site 716540008926 phosphorylation site [posttranslational modification] 716540008927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716540008928 ATP binding site [chemical binding]; other site 716540008929 Mg2+ binding site [ion binding]; other site 716540008930 G-X-G motif; other site 716540008931 Signal peptide predicted for EAM_1802 by SignalP 2.0 HMM (Signal peptide probability 0.975) with cleavage site probability 0.334 between residues 28 and 29 716540008932 2 transmembrane helices predicted for EAM_1802 by TMHMM2.0 at aa 5-27 and 139-156 716540008933 HMMPfam hit to PF00672, HAMP domain, score 4.1e-08 716540008934 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 5.8e-10 716540008935 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 4.9e-40 716540008936 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 716540008937 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 716540008938 active site 716540008939 Zn binding site [ion binding]; other site 716540008940 HMMPfam hit to PF02074, Carboxypeptidase Taq (M32) metallopepti, score 2.8e-138 716540008941 Signal peptide predicted for EAM_1805 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.992 between residues 21 and 22 716540008942 HMMPfam hit to PF06392, Acid shock protein repeat, score 0.04 716540008943 HMMPfam hit to PF06392, Acid shock protein repeat, score 2.6 716540008944 HMMPfam hit to PF06392, Acid shock protein repeat, score 2.6 716540008945 HMMPfam hit to PF06392, Acid shock protein repeat, score 2.6 716540008946 HMMPfam hit to PF06392, Acid shock protein repeat, score 2.6 716540008947 1 transmembrane helix predicted for EAM_1806 by TMHMM2.0 at aa 30-49 716540008948 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 716540008949 Signal peptide predicted for EAM_1807 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 20 and 21 716540008950 HMMPfam hit to PF00089, Trypsin, score 0.00013 716540008951 PS00134 Serine proteases, trypsin family, histidine active site. 716540008952 PS00135 Serine proteases, trypsin family, serine active site. 716540008953 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 716540008954 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 716540008955 amidase catalytic site [active] 716540008956 Zn binding residues [ion binding]; other site 716540008957 substrate binding site [chemical binding]; other site 716540008958 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 716540008959 Signal peptide predicted for EAM_1808 by SignalP 2.0 HMM (Signal peptide probability 0.986) with cleavage site probability 0.547 between residues 18 and 19 716540008960 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540008961 HMMPfam hit to PF01510, N-acetylmuramoyl-L-alanine amidase, score 3.6e-34 716540008962 HMMPfam hit to PF01471, peptidoglycan binding domain, score 7.2e-11 716540008963 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 716540008964 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 716540008965 ATP binding site [chemical binding]; other site 716540008966 putative Mg++ binding site [ion binding]; other site 716540008967 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 716540008968 nucleotide binding region [chemical binding]; other site 716540008969 ATP-binding site [chemical binding]; other site 716540008970 Helicase associated domain (HA2); Region: HA2; pfam04408 716540008971 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 716540008972 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 716540008973 HMMPfam hit to PF07717, Domain of unknown function (DUF1605), score 3.9e-15 716540008974 HMMPfam hit to PF04408, Helicase associated domain (HA2), score 8.3e-26 716540008975 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 8.5e-11 716540008976 PS00017 ATP/GTP-binding site motif A (P-loop). 716540008977 azoreductase; Reviewed; Region: PRK00170 716540008978 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 716540008979 HMMPfam hit to PF02525, Flavodoxin-like fold, score 9e-60 716540008980 short chain dehydrogenase; Provisional; Region: PRK09291 716540008981 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 716540008982 NAD(P) binding site [chemical binding]; other site 716540008983 active site 716540008984 HMMPfam hit to PF00106, short chain dehydrogenase, score 1.8e-12 716540008985 PS00061 Short-chain dehydrogenases/reductases family signature. 716540008986 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 716540008987 HMMPfam hit to PF07027, Protein of unknown function (DUF1318), score 1.2e-51 716540008988 Signal peptide predicted for EAM_1813 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 21 and 22 716540008989 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 716540008990 Signal peptide predicted for EAM_1814 by SignalP 2.0 HMM (Signal peptide probability 0.979) with cleavage site probability 0.952 between residues 26 and 27 716540008991 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540008992 hypothetical protein; Provisional; Region: PRK10695 716540008993 1 transmembrane helix predicted for EAM_1815 by TMHMM2.0 at aa 5-27 716540008994 Signal peptide predicted for EAM_1815 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.515 between residues 26 and 27 716540008995 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 716540008996 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 716540008997 putative ligand binding site [chemical binding]; other site 716540008998 putative NAD binding site [chemical binding]; other site 716540008999 catalytic site [active] 716540009000 HMMPfam hit to PF00389, D-isomer specific 2-hydroxyacid dehydrog, score 1e-39 716540009001 HMMPfam hit to PF02826, D-isomer specific 2-hydroxyacid dehydrog, score 1.7e-69 716540009002 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 716540009003 PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. 716540009004 PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 716540009005 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 716540009006 Domain of unknown function (DUF333); Region: DUF333; pfam03891 716540009007 Signal peptide predicted for EAM_1817 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.786 between residues 22 and 23 716540009008 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540009009 Uncharacterized conserved protein [Function unknown]; Region: COG1359 716540009010 HMMPfam hit to PF03992, Antibiotic biosynthesis monooxygenase, score 6.9e-19 716540009011 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 716540009012 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 716540009013 ATP binding site [chemical binding]; other site 716540009014 Mg++ binding site [ion binding]; other site 716540009015 motif III; other site 716540009016 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 716540009017 nucleotide binding region [chemical binding]; other site 716540009018 ATP-binding site [chemical binding]; other site 716540009019 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 716540009020 putative RNA binding site [nucleotide binding]; other site 716540009021 HMMPfam hit to PF03880, DbpA RNA binding domain, score 1.4e-27 716540009022 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 3.1e-30 716540009023 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 3.2e-66 716540009024 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 716540009025 PS00017 ATP/GTP-binding site motif A (P-loop). 716540009026 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 716540009027 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 716540009028 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 716540009029 Ligand Binding Site [chemical binding]; other site 716540009030 HMMPfam hit to PF01171, PP-loop family, score 3.4e-06 716540009031 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 716540009032 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 716540009033 Ca binding site [ion binding]; other site 716540009034 active site 716540009035 catalytic site [active] 716540009036 HMMPfam hit to PF00128, Alpha amylase, catalytic domain, score 2.6e-117 716540009037 PS00017 ATP/GTP-binding site motif A (P-loop). 716540009038 Signal peptide predicted for EAM_1823 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.978 between residues 27 and 28 716540009039 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 716540009040 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 716540009041 Cl binding site [ion binding]; other site 716540009042 oligomer interface [polypeptide binding]; other site 716540009043 HMMPfam hit to PF01544, CorA-like Mg2+ transporter protein, score 2.3e-05 716540009044 2 transmembrane helices predicted for EAM_1824 by TMHMM2.0 at aa 272-294 and 299-321 716540009045 Fimbrial operon 2 716540009046 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 716540009047 Signal peptide predicted for EAM_1825 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.961 between residues 22 and 23 716540009048 HMMPfam hit to PF06551, Protein of unknown function (DUF1120), score 1.8e-25 716540009049 putative fimbrial chaperone protein; Provisional; Region: PRK09918 716540009050 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 716540009051 Signal peptide predicted for EAM_1826 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.739 between residues 23 and 24 716540009052 HMMPfam hit to PF00345, Gram-negative pili assembly chaperone, score 1.3e-13 716540009053 PS00017 ATP/GTP-binding site motif A (P-loop). 716540009054 putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304 716540009055 PapC N-terminal domain; Region: PapC_N; pfam13954 716540009056 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 716540009057 PapC C-terminal domain; Region: PapC_C; pfam13953 716540009058 Signal peptide predicted for EAM_1827 by SignalP 2.0 HMM (Signal peptide probability 0.684) with cleavage site probability 0.605 between residues 31 and 32 716540009059 HMMPfam hit to PF00577, Fimbrial Usher protein, score 1.1e-86 716540009060 hypothetical protein; Provisional; Region: PRK15301 716540009061 Signal peptide predicted for EAM_1828 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.873 between residues 21 and 22 716540009062 PS00017 ATP/GTP-binding site motif A (P-loop). 716540009063 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540009064 AAA domain; Region: AAA_33; pfam13671 716540009065 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 716540009066 active site 716540009067 PS00017 ATP/GTP-binding site motif A (P-loop). 716540009068 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 716540009069 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 716540009070 peptide binding site [polypeptide binding]; other site 716540009071 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 8e-75 716540009072 Signal peptide predicted for EAM_1831 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 22 and 23 716540009073 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 716540009074 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 716540009075 active site 716540009076 PS00909 Mandelate racemase / muconate lactonizing enzyme family signature 2. 716540009077 HMMPfam hit to PF02746, Mandelate racemase / muconate lactonizing en, score 9.2e-21 716540009078 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 716540009079 dimer interface [polypeptide binding]; other site 716540009080 catalytic triad [active] 716540009081 peroxidatic and resolving cysteines [active] 716540009082 HMMPfam hit to PF08534, Redoxin, score 3.4e-45 716540009083 HMMPfam hit to PF00578, AhpC/TSA family, score 0.00044 716540009084 PS01265 Tpx family signature. 716540009085 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 716540009086 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 716540009087 putative aromatic amino acid binding site; other site 716540009088 PAS domain; Region: PAS; smart00091 716540009089 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716540009090 Walker A motif; other site 716540009091 ATP binding site [chemical binding]; other site 716540009092 Walker B motif; other site 716540009093 arginine finger; other site 716540009094 Predicted helix-turn-helix motif with score 1684.000, SD 4.92 at aa 488-509, sequence PSTRKLAKRLGVSHTAIANKLR 716540009095 PS00688 Sigma-54 interaction domain C-terminal part signature. 716540009096 HMMPfam hit to PF00158, Sigma-54 interaction domain, score 1.5e-121 716540009097 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 716540009098 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 716540009099 HMMPfam hit to PF01842, ACT domain, score 3.6e-06 716540009100 hypothetical protein; Provisional; Region: PRK05415 716540009101 Domain of unknown function (DUF697); Region: DUF697; cl12064 716540009102 HMMPfam hit to PF05128, Family of unknown function (DUF697), score 2.1e-168 716540009103 3 transmembrane helices predicted for EAM_1835 by TMHMM2.0 at aa 72-94, 98-120 and 210-232 716540009104 Predicted ATPase [General function prediction only]; Region: COG3106 716540009105 HMMPfam hit to PF04317, YcjX-like family, DUF463, score 0 716540009106 PS00017 ATP/GTP-binding site motif A (P-loop). 716540009107 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 716540009108 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 716540009109 phage shock protein C; Region: phageshock_pspC; TIGR02978 716540009110 HMMPfam hit to PF04024, PspC domain, score 2.3e-25 716540009111 1 transmembrane helix predicted for EAM_1838 by TMHMM2.0 at aa 35-57 716540009112 phage shock protein B; Provisional; Region: pspB; PRK09458 716540009113 HMMPfam hit to PF06667, Phage shock protein B, score 1.1e-44 716540009114 1 transmembrane helix predicted for EAM_1839 by TMHMM2.0 at aa 4-26 716540009115 phage shock protein PspA; Provisional; Region: PRK10698 716540009116 HMMPfam hit to PF04012, PspA/IM30 family, score 4.4e-54 716540009117 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 716540009118 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716540009119 Walker A motif; other site 716540009120 ATP binding site [chemical binding]; other site 716540009121 Walker B motif; other site 716540009122 arginine finger; other site 716540009123 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 716540009124 HMMPfam hit to PF00158, Sigma-54 interaction domain, score 1.3e-122 716540009125 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 716540009126 PS00688 Sigma-54 interaction domain C-terminal part signature. 716540009127 Predicted helix-turn-helix motif with score 1229.000, SD 3.37 at aa 300-321, sequence FNQRRAADLLVVTYHQLRAMLK 716540009128 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 716540009129 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 716540009130 peptide binding site [polypeptide binding]; other site 716540009131 Signal peptide predicted for EAM_1842 by SignalP 2.0 HMM (Signal peptide probability 0.965) with cleavage site probability 0.717 between residues 16 and 17 716540009132 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 6.8e-79 716540009133 PS01040 Bacterial extracellular solute-binding proteins, family 5 signature. 716540009134 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 716540009135 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540009136 dimer interface [polypeptide binding]; other site 716540009137 conserved gate region; other site 716540009138 putative PBP binding loops; other site 716540009139 ABC-ATPase subunit interface; other site 716540009140 Signal peptide predicted for EAM_1843 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.787 between residues 37 and 38 716540009141 5 transmembrane helices predicted for EAM_1843 by TMHMM2.0 at aa 9-31, 80-102, 114-136, 251-273 and 286-308 716540009142 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 3.1e-51 716540009143 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 716540009144 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540009145 dimer interface [polypeptide binding]; other site 716540009146 conserved gate region; other site 716540009147 putative PBP binding loops; other site 716540009148 ABC-ATPase subunit interface; other site 716540009149 4 transmembrane helices predicted for EAM_1844 by TMHMM2.0 at aa 31-53, 96-118, 131-153 and 261-283 716540009150 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 3.4e-31 716540009151 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 716540009152 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 716540009153 Walker A/P-loop; other site 716540009154 ATP binding site [chemical binding]; other site 716540009155 Q-loop/lid; other site 716540009156 ABC transporter signature motif; other site 716540009157 Walker B; other site 716540009158 D-loop; other site 716540009159 H-loop/switch region; other site 716540009160 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 716540009161 HMMPfam hit to PF00005, ABC transporter, score 1.4e-64 716540009162 PS00017 ATP/GTP-binding site motif A (P-loop). 716540009163 HMMPfam hit to PF08352, Oligopeptide/dipeptide transporter, C-termi, score 3e-25 716540009164 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 716540009165 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 716540009166 Walker A/P-loop; other site 716540009167 ATP binding site [chemical binding]; other site 716540009168 Q-loop/lid; other site 716540009169 ABC transporter signature motif; other site 716540009170 Walker B; other site 716540009171 D-loop; other site 716540009172 H-loop/switch region; other site 716540009173 HMMPfam hit to PF00005, ABC transporter, score 3e-60 716540009174 PS00017 ATP/GTP-binding site motif A (P-loop). 716540009175 PS00211 ABC transporters family signature. 716540009176 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 716540009177 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 716540009178 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 716540009179 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 716540009180 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716540009181 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716540009182 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 716540009183 dimerization interface [polypeptide binding]; other site 716540009184 HMMPfam hit to PF03466, LysR substrate binding domain, score 8.7e-24 716540009185 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1e-15 716540009186 PS00044 Bacterial regulatory proteins, lysR family signature. 716540009187 Predicted helix-turn-helix motif with score 1297.000, SD 3.60 at aa 16-37, sequence RHFGRAAEASFVSQPTLSMRLK 716540009188 PAAR motif; Region: PAAR_motif; pfam05488 716540009189 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 716540009190 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 716540009191 Signal peptide predicted for EAM_1851 by SignalP 2.0 HMM (Signal peptide probability 0.950) with cleavage site probability 0.543 between residues 21 and 22 716540009192 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 716540009193 Signal peptide predicted for EAM_1852 by SignalP 2.0 HMM (Signal peptide probability 0.864) with cleavage site probability 0.361 between residues 18 and 19 716540009194 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 716540009195 Signal peptide predicted for EAM_1853 by SignalP 2.0 HMM (Signal peptide probability 0.748) with cleavage site probability 0.326 between residues 21 and 22 716540009196 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 716540009197 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 716540009198 putative molybdopterin cofactor binding site [chemical binding]; other site 716540009199 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 716540009200 putative molybdopterin cofactor binding site; other site 716540009201 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 5.3e-10 716540009202 HMMPfam hit to PF01568, Molydopterin dinucleotide binding dom, score 1.6e-10 716540009203 exoribonuclease II; Provisional; Region: PRK05054 716540009204 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 716540009205 RNB domain; Region: RNB; pfam00773 716540009206 S1 RNA binding domain; Region: S1; pfam00575 716540009207 HMMPfam hit to PF08206, Ribonuclease B OB domain, score 3.4e-20 716540009208 HMMPfam hit to PF00773, RNB-like protein, score 2.2e-88 716540009209 PS01175 Ribonuclease II family signature. 716540009210 HMMPfam hit to PF00575, S1 RNA binding domain, score 0.0001 716540009211 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 716540009212 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 716540009213 intersubunit interface [polypeptide binding]; other site 716540009214 active site 716540009215 Zn2+ binding site [ion binding]; other site 716540009216 HMMPfam hit to PF00596, Class II Aldolase and Adducin N-terminal, score 2e-87 716540009217 lipoprotein; Provisional; Region: PRK10540 716540009218 Signal peptide predicted for EAM_1857 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.486 between residues 23 and 24 716540009219 2 transmembrane helices predicted for EAM_1857 by TMHMM2.0 at aa 10-28 and 35-57 716540009220 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540009221 translation initiation factor Sui1; Validated; Region: PRK06824 716540009222 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 716540009223 putative rRNA binding site [nucleotide binding]; other site 716540009224 HMMPfam hit to PF01253, Translation initiation factor SUI1, score 2.1e-33 716540009225 PS01118 Translation initiation factor SUI1 signature. 716540009226 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 716540009227 active site 716540009228 dimer interface [polypeptide binding]; other site 716540009229 HMMPfam hit to PF00215, Orotidine 5'-phosphate decarboxylase / HUMP, score 6.4e-86 716540009230 PS00156 Orotidine 5'-phosphate decarboxylase active site. 716540009231 tetratricopeptide repeat protein; Provisional; Region: PRK11788 716540009232 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 716540009233 TPR motif; other site 716540009234 binding surface 716540009235 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 716540009236 binding surface 716540009237 TPR motif; other site 716540009238 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 0.0014 716540009239 Predicted membrane protein [Function unknown]; Region: COG3771 716540009240 HMMPfam hit to PF06305, Protein of unknown function (DUF1049), score 6.4e-48 716540009241 2 transmembrane helices predicted for EAM_1863 by TMHMM2.0 at aa 5-23 and 43-65 716540009242 Signal peptide predicted for EAM_1863 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.563 between residues 24 and 25 716540009243 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 716540009244 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 716540009245 active site 716540009246 HMMPfam hit to PF01569, PAP2 superfamily, score 3.5e-18 716540009247 6 transmembrane helices predicted for EAM_1864 by TMHMM2.0 at aa 7-29, 49-68, 75-92, 157-179, 186-208 and 212-229 716540009248 Signal peptide predicted for EAM_1864 by SignalP 2.0 HMM (Signal peptide probability 0.984) with cleavage site probability 0.520 between residues 24 and 25 716540009249 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 716540009250 dimerization interface [polypeptide binding]; other site 716540009251 active site 716540009252 HMMPfam hit to PF00925, GTP cyclohydrolase II, score 5.3e-119 716540009253 aconitate hydratase; Validated; Region: PRK09277 716540009254 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 716540009255 substrate binding site [chemical binding]; other site 716540009256 ligand binding site [chemical binding]; other site 716540009257 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 716540009258 substrate binding site [chemical binding]; other site 716540009259 HMMPfam hit to PF00694, Aconitase C-terminal domain, score 9.6e-63 716540009260 HMMPfam hit to PF00330, Aconitase family (aconitate hydratase), score 9.1e-255 716540009261 PS01244 Aconitase family signature 2. 716540009262 PS00450 Aconitase family signature 1. 716540009263 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 716540009264 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716540009265 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 716540009266 substrate binding site [chemical binding]; other site 716540009267 putative dimerization interface [polypeptide binding]; other site 716540009268 HMMPfam hit to PF03466, LysR substrate binding domain, score 4.5e-45 716540009269 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 716540009270 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 8.6e-15 716540009271 PS00044 Bacterial regulatory proteins, lysR family signature. 716540009272 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 716540009273 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 716540009274 active site 716540009275 interdomain interaction site; other site 716540009276 putative metal-binding site [ion binding]; other site 716540009277 nucleotide binding site [chemical binding]; other site 716540009278 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 716540009279 domain I; other site 716540009280 DNA binding groove [nucleotide binding] 716540009281 phosphate binding site [ion binding]; other site 716540009282 domain II; other site 716540009283 domain III; other site 716540009284 nucleotide binding site [chemical binding]; other site 716540009285 catalytic site [active] 716540009286 domain IV; other site 716540009287 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 716540009288 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 716540009289 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 716540009290 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 716540009291 HMMPfam hit to PF08272, Topoisomerase I zinc-ribbon-like, score 5.9e-23 716540009292 HMMPfam hit to PF08272, Topoisomerase I zinc-ribbon-like, score 2e-15 716540009293 HMMPfam hit to PF01396, Topoisomerase DNA binding C4 zinc fing, score 5e-14 716540009294 HMMPfam hit to PF01396, Topoisomerase DNA binding C4 zinc fing, score 0.0025 716540009295 HMMPfam hit to PF01131, DNA topoisomerase, score 1.7e-179 716540009296 PS00396 Prokaryotic DNA topoisomerase I active site. 716540009297 HMMPfam hit to PF01751, Toprim domain, score 1.2e-35 716540009298 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 716540009299 putative inner membrane peptidase; Provisional; Region: PRK11778 716540009300 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 716540009301 tandem repeat interface [polypeptide binding]; other site 716540009302 oligomer interface [polypeptide binding]; other site 716540009303 active site residues [active] 716540009304 HMMPfam hit to PF01343, Peptidase family S49, score 1.4e-61 716540009305 HMMPfam hit to PF08496, Peptidase family S49 N-terminal, score 4.6e-91 716540009306 1 transmembrane helix predicted for EAM_1871 by TMHMM2.0 at aa 7-29 716540009307 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 716540009308 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 716540009309 NAD(P) binding site [chemical binding]; other site 716540009310 active site 716540009311 HMMPfam hit to PF00106, short chain dehydrogenase, score 2.1e-27 716540009312 PS00061 Short-chain dehydrogenases/reductases family signature. 716540009313 PS00017 ATP/GTP-binding site motif A (P-loop). 716540009314 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 716540009315 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 716540009316 RNA binding surface [nucleotide binding]; other site 716540009317 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 716540009318 probable active site [active] 716540009319 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 2.3e-11 716540009320 PS01149 Rsu family of pseudouridine synthase signature. 716540009321 HMMPfam hit to PF01479, S4 domain, score 5.6e-09 716540009322 hypothetical protein; Provisional; Region: PRK11630 716540009323 HMMPfam hit to PF01300, yrdC domain, score 7.3e-69 716540009324 PS01147 SUA5/yciO/yrdC family signature. 716540009325 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 716540009326 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 716540009327 active site 716540009328 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 716540009329 HMMPfam hit to PF02811, PHP domain, score 1.8e-29 716540009330 anthranilate synthase component I; Provisional; Region: PRK13564 716540009331 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 716540009332 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 716540009333 HMMPfam hit to PF04715, Anthranilate synthase component I, N, score 1.4e-26 716540009334 PS00012 Phosphopantetheine attachment site. 716540009335 HMMPfam hit to PF00425, chorismate binding enzyme, score 2.4e-152 716540009336 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 716540009337 Glutamine amidotransferase class-I; Region: GATase; pfam00117 716540009338 glutamine binding [chemical binding]; other site 716540009339 catalytic triad [active] 716540009340 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 3.2e-69 716540009341 PS00442 Glutamine amidotransferases class-I active site. 716540009342 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 716540009343 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 716540009344 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 716540009345 HMMPfam hit to PF02885, Glycosyl transferase family, helical, score 2.6e-23 716540009346 HMMPfam hit to PF00591, Glycosyl transferase family, a/b doma, score 1.1e-150 716540009347 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 716540009348 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 716540009349 active site 716540009350 ribulose/triose binding site [chemical binding]; other site 716540009351 phosphate binding site [ion binding]; other site 716540009352 substrate (anthranilate) binding pocket [chemical binding]; other site 716540009353 product (indole) binding pocket [chemical binding]; other site 716540009354 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 716540009355 active site 716540009356 HMMPfam hit to PF00218, Indole-3-glycerol phosphate synthase, score 4.3e-146 716540009357 PS00614 Indole-3-glycerol phosphate synthase signature. 716540009358 HMMPfam hit to PF00697, N-(5'phosphoribosyl)anthranilate (PRA) isome, score 1.6e-77 716540009359 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 716540009360 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 716540009361 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716540009362 catalytic residue [active] 716540009363 HMMPfam hit to PF00291, Pyridoxal-phosphate dependent enzyme, score 1.7e-120 716540009364 PS00168 Tryptophan synthase beta chain pyridoxal-phosphate attachment site. 716540009365 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 716540009366 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 716540009367 substrate binding site [chemical binding]; other site 716540009368 active site 716540009369 catalytic residues [active] 716540009370 heterodimer interface [polypeptide binding]; other site 716540009371 HMMPfam hit to PF00290, Tryptophan synthase alpha chain, score 6.9e-138 716540009372 PS00167 Tryptophan synthase alpha chain signature. 716540009373 BON domain; Region: BON; pfam04972 716540009374 Signal peptide predicted for EAM_1883 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.640 between residues 22 and 23 716540009375 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540009376 HMMPfam hit to PF04972, phospholipid-binding domain, score 1.5e-12 716540009377 outer membrane protein W; Provisional; Region: PRK10959 716540009378 HMMPfam hit to PF03922, OmpW family, score 4e-85 716540009379 PS00695 Enterobacterial virulence outer membrane protein signature 2. 716540009380 PS00327 Bacterial rhodopsins retinal binding site. 716540009381 Signal peptide predicted for EAM_1884 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.920 between residues 20 and 21 716540009382 hypothetical protein; Provisional; Region: PRK02868 716540009383 HMMPfam hit to PF06790, Uncharacterised protein family (UPF0259), score 1.1e-101 716540009384 6 transmembrane helices predicted for EAM_1885 by TMHMM2.0 at aa 20-42, 84-106, 127-149, 153-175, 188-210 and 220-242 716540009385 intracellular septation protein A; Reviewed; Region: PRK00259 716540009386 HMMPfam hit to PF04279, Intracellular septation protein A, score 1.3e-101 716540009387 Signal peptide predicted for EAM_1886 by SignalP 2.0 HMM (Signal peptide probability 0.640) with cleavage site probability 0.518 between residues 38 and 39 716540009388 5 transmembrane helices predicted for EAM_1886 by TMHMM2.0 at aa 22-44, 51-68, 78-95, 119-141 and 151-173 716540009389 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 716540009390 HMMPfam hit to PF03061, Thioesterase superfamily, score 4.9e-22 716540009391 transport protein TonB; Provisional; Region: PRK10819 716540009392 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 716540009393 HMMPfam hit to PF03544, Gram-negative bacterial tonB protein, score 3.5e-17 716540009394 1 transmembrane helix predicted for EAM_1888 by TMHMM2.0 at aa 13-35 716540009395 YciI-like protein; Reviewed; Region: PRK11370 716540009396 HMMPfam hit to PF03795, YCII-related domain, score 5.6e-37 716540009397 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 716540009398 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 716540009399 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 716540009400 putative active site [active] 716540009401 catalytic site [active] 716540009402 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 716540009403 putative active site [active] 716540009404 catalytic site [active] 716540009405 2 transmembrane helices predicted for EAM_1891 by TMHMM2.0 at aa 10-29 and 36-58 716540009406 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 4.5e-07 716540009407 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 2.3e-06 716540009408 dsDNA-mimic protein; Reviewed; Region: PRK05094 716540009409 HMMPfam hit to PF04269, Protein of unknown function, DUF440, score 2.9e-39 716540009410 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 716540009411 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 716540009412 Walker A/P-loop; other site 716540009413 ATP binding site [chemical binding]; other site 716540009414 Q-loop/lid; other site 716540009415 ABC transporter signature motif; other site 716540009416 Walker B; other site 716540009417 D-loop; other site 716540009418 H-loop/switch region; other site 716540009419 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 716540009420 HMMPfam hit to PF08352, Oligopeptide/dipeptide transporter, C-termi, score 6.7e-34 716540009421 HMMPfam hit to PF00005, ABC transporter, score 2.5e-63 716540009422 PS00211 ABC transporters family signature. 716540009423 PS00017 ATP/GTP-binding site motif A (P-loop). 716540009424 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 716540009425 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 716540009426 Walker A/P-loop; other site 716540009427 ATP binding site [chemical binding]; other site 716540009428 Q-loop/lid; other site 716540009429 ABC transporter signature motif; other site 716540009430 Walker B; other site 716540009431 D-loop; other site 716540009432 H-loop/switch region; other site 716540009433 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 716540009434 HMMPfam hit to PF08352, Oligopeptide/dipeptide transporter, C-termi, score 7e-28 716540009435 HMMPfam hit to PF00005, ABC transporter, score 4e-63 716540009436 PS00211 ABC transporters family signature. 716540009437 PS00017 ATP/GTP-binding site motif A (P-loop). 716540009438 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 716540009439 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 716540009440 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540009441 dimer interface [polypeptide binding]; other site 716540009442 conserved gate region; other site 716540009443 putative PBP binding loops; other site 716540009444 ABC-ATPase subunit interface; other site 716540009445 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1e-39 716540009446 6 transmembrane helices predicted for EAM_1895 by TMHMM2.0 at aa 40-62, 109-131, 143-160, 164-183, 214-236 and 268-290 716540009447 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 716540009448 PS00017 ATP/GTP-binding site motif A (P-loop). 716540009449 Signal peptide predicted for EAM_1895 by SignalP 2.0 HMM (Signal peptide probability 0.663) with cleavage site probability 0.530 between residues 63 and 64 716540009450 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 716540009451 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 716540009452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540009453 dimer interface [polypeptide binding]; other site 716540009454 conserved gate region; other site 716540009455 putative PBP binding loops; other site 716540009456 ABC-ATPase subunit interface; other site 716540009457 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 9.9e-55 716540009458 6 transmembrane helices predicted for EAM_1896 by TMHMM2.0 at aa 5-27, 99-121, 134-156, 166-188, 228-250 and 278-300 716540009459 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 716540009460 Signal peptide predicted for EAM_1896 by SignalP 2.0 HMM (Signal peptide probability 0.893) with cleavage site probability 0.405 between residues 32 and 33 716540009461 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 716540009462 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 716540009463 peptide binding site [polypeptide binding]; other site 716540009464 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 1.2e-84 716540009465 Signal peptide predicted for EAM_1897 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 25 and 26 716540009466 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 716540009467 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 716540009468 peptide binding site [polypeptide binding]; other site 716540009469 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 2.6e-81 716540009470 Signal peptide predicted for EAM_1898 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 24 and 25 716540009471 hypothetical protein; Provisional; Region: PRK11111 716540009472 6 transmembrane helices predicted for EAM_1899 by TMHMM2.0 at aa 10-32, 52-74, 78-97, 118-140, 150-168 and 189-211 716540009473 HMMPfam hit to PF01914, MarC family integral membrane protein, score 2.4e-97 716540009474 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 716540009475 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 716540009476 putative catalytic cysteine [active] 716540009477 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 716540009478 putative active site [active] 716540009479 metal binding site [ion binding]; metal-binding site 716540009480 HMMPfam hit to PF00171, Aldehyde dehydrogenase family, score 3.5e-07 716540009481 HMMPfam hit to PF00465, Iron-containing alcohol dehydrogenase, score 1.2e-199 716540009482 PS00060 Iron-containing alcohol dehydrogenases signature 2. 716540009483 PS00041 Bacterial regulatory proteins, araC family signature. 716540009484 benzoate transport; Region: 2A0115; TIGR00895 716540009485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540009486 putative substrate translocation pore; other site 716540009487 HMMPfam hit to PF00083, Sugar (and other) transporter, score 6.6e-06 716540009488 10 transmembrane helices predicted for EAM_1901 by TMHMM2.0 at aa 24-46, 56-78, 91-110, 115-137, 150-172, 177-199, 259-278, 293-315, 322-344 and 407-429 716540009489 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 9.1e-50 716540009490 PS00216 Sugar transport proteins signature 1. 716540009491 PS00217 Sugar transport proteins signature 2. 716540009492 protocatechuate 4,5-dioxygenase; Provisional; Region: PRK13367 716540009493 The N-terminal domain of the Class III extradiol dioxygenase, Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_Doxase_N; cd07950 716540009494 putative active site [active] 716540009495 Fe(II) binding site [ion binding]; other site 716540009496 putative dimer interface [polypeptide binding]; other site 716540009497 The C-terminal domain of Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_dioxygenase_C; cd07923 716540009498 putative dimer interface [polypeptide binding]; other site 716540009499 putative N- and C-terminal domain interface [polypeptide binding]; other site 716540009500 HMMPfam hit to PF02900, Catalytic LigB subunit of aromatic ring-open, score 2.7e-62 716540009501 HMMPfam hit to PF07746, Aromatic-ring-opening dioxygenase LigAB, Lig, score 8.2e-41 716540009502 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 716540009503 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 716540009504 active site 716540009505 HMMPfam hit to PF04909, Amidohydrolase, score 3.1e-43 716540009506 Dehydroquinase class II; Region: DHquinase_II; pfam01220 716540009507 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 716540009508 trimer interface [polypeptide binding]; other site 716540009509 active site 716540009510 dimer interface [polypeptide binding]; other site 716540009511 HMMPfam hit to PF01220, Dehydroquinase class II, score 1.3e-78 716540009512 PS01029 Dehydroquinase class II signature. 716540009513 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716540009514 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716540009515 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 716540009516 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716540009517 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 716540009518 putative dimerization interface [polypeptide binding]; other site 716540009519 HMMPfam hit to PF03466, LysR substrate binding domain, score 7.1e-40 716540009520 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 6.5e-15 716540009521 PS00044 Bacterial regulatory proteins, lysR family signature. 716540009522 Predicted helix-turn-helix motif with score 1784.000, SD 5.26 at aa 25-146, sequence GSVSKAADELFRTQSAITRSIRDLELTLAVPLFERHAGGMMLTDFGKCVLPRAHRAV DELLQIPLQLAKLQGRASPRGDIEPLWLFNVRRLQIFITLCQTRHMQSVAARLGLSQ PAVSAALK 716540009523 Predicted helix-turn-helix motif with score 1784.000, SD 5.26 at aa 125-146, sequence RHMQSVAARLGLSQPAVSAALK 716540009524 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 8.5e-20 716540009525 PS00044 Bacterial regulatory proteins, lysR family signature. 716540009526 Predicted helix-turn-helix motif with score 1784.000, SD 5.26 at aa 25-46, sequence GSVSKAADELFRTQSAITRSIR 716540009527 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 716540009528 HMMPfam hit to PF02585, GlcNAc-PI de-N-acetylase, score 1.4e-36 716540009529 hypothetical protein; Provisional; Region: PRK09262 716540009530 HMMPfam hit to PF03737, Demethylmenaquinone methyltransferase, score 1.2e-18 716540009531 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 716540009532 Signal peptide predicted for EAM_1908 by SignalP 2.0 HMM (Signal peptide probability 0.876) with cleavage site probability 0.821 between residues 23 and 24 716540009533 HMMPfam hit to PF04303, Protein of unknown function (DUF453), score 2.6e-167 716540009534 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 716540009535 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 716540009536 HMMPfam hit to PF03446, NAD binding domain of 6-phosphogluconat, score 2.4e-06 716540009537 Domain of unknown function (DUF336); Region: DUF336; pfam03928 716540009538 Signal peptide predicted for EAM_1910 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 21 and 22 716540009539 HMMPfam hit to PF03928, Domain of unknown function (DUF336), score 1.3e-20 716540009540 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 716540009541 Signal peptide predicted for EAM_1911 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.603 between residues 38 and 39 716540009542 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 716540009543 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 716540009544 HMMPfam hit to PF00732, GMC oxidoreductase, score 0.0038 716540009545 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 716540009546 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 716540009547 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 716540009548 Signal peptide predicted for EAM_1913 by SignalP 2.0 HMM (Signal peptide probability 0.953) with cleavage site probability 0.755 between residues 22 and 23 716540009549 PS00190 Cytochrome c family heme-binding site signature. 716540009550 PS00190 Cytochrome c family heme-binding site signature. 716540009551 HMMPfam hit to PF00034, Cytochrome c, score 2.9e-05 716540009552 PS00190 Cytochrome c family heme-binding site signature. 716540009553 thymidine kinase; Provisional; Region: PRK04296 716540009554 HMMPfam hit to PF00265, Thymidine kinase, score 7.2e-94 716540009555 PS00603 Thymidine kinase cellular-type signature. 716540009556 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 716540009557 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 716540009558 HMMPfam hit to PF00816, H-NS histone family, score 2e-49 716540009559 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 716540009560 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 716540009561 putative NAD(P) binding site [chemical binding]; other site 716540009562 active site 716540009563 putative substrate binding site [chemical binding]; other site 716540009564 HMMPfam hit to PF04321, RmlD substrate binding domain, score 4e-05 716540009565 HMMPfam hit to PF01073, 3-beta hydroxysteroid dehydrogenase/iso, score 1.7e-08 716540009566 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase fam, score 2.6e-58 716540009567 HMMPfam hit to PF07993, Male sterility protein, score 2.2e-05 716540009568 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 716540009569 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 716540009570 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 716540009571 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 716540009572 HMMPfam hit to PF03720, UDP-glucose/GDP-mannose dehydrogenase, score 1e-31 716540009573 PS00017 ATP/GTP-binding site motif A (P-loop). 716540009574 HMMPfam hit to PF00984, UDP-glucose/GDP-mannose dehydrogenase, score 8.6e-52 716540009575 HMMPfam hit to PF03721, UDP-glucose/GDP-mannose dehydrogenase, score 1.2e-82 716540009576 Signal peptide predicted for EAM_1917 by SignalP 2.0 HMM (Signal peptide probability 0.602) with cleavage site probability 0.312 between residues 16 and 17 716540009577 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 716540009578 active site 716540009579 tetramer interface; other site 716540009580 HMMPfam hit to PF00483, Nucleotidyl transferase, score 3.7e-12 716540009581 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716540009582 active site 716540009583 response regulator of RpoS; Provisional; Region: PRK10693 716540009584 phosphorylation site [posttranslational modification] 716540009585 intermolecular recognition site; other site 716540009586 dimerization interface [polypeptide binding]; other site 716540009587 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.6e-34 716540009588 SEC-C motif; Region: SEC-C; pfam02810 716540009589 hypothetical protein; Provisional; Region: PRK04233 716540009590 HMMPfam hit to PF02810, SEC-C motif, score 8.6e-06 716540009591 HMMPfam hit to PF02810, SEC-C motif, score 0.0016 716540009592 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 716540009593 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 716540009594 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 716540009595 putative active site [active] 716540009596 putative substrate binding site [chemical binding]; other site 716540009597 putative cosubstrate binding site; other site 716540009598 catalytic site [active] 716540009599 HMMPfam hit to PF01842, ACT domain, score 1.4e-05 716540009600 HMMPfam hit to PF00551, Formyl transferase, score 3e-73 716540009601 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 716540009602 putative catalytic site [active] 716540009603 putative phosphate binding site [ion binding]; other site 716540009604 active site 716540009605 metal binding site A [ion binding]; metal-binding site 716540009606 DNA binding site [nucleotide binding] 716540009607 putative AP binding site [nucleotide binding]; other site 716540009608 putative metal binding site B [ion binding]; other site 716540009609 HMMPfam hit to PF03372, Endonuclease/Exonuclease/phosphatase fa, score 4.1e-51 716540009610 PS00726 AP endonucleases family 1 signature 1. 716540009611 PS00728 AP endonucleases family 1 signature 3. 716540009612 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 716540009613 HMMPfam hit to PF07383, Protein of unknown function (DUF1496), score 5.1e-26 716540009614 Signal peptide predicted for EAM_1923 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 19 and 20 716540009615 DNA topoisomerase III; Provisional; Region: PRK07726 716540009616 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 716540009617 active site 716540009618 putative interdomain interaction site [polypeptide binding]; other site 716540009619 putative metal-binding site [ion binding]; other site 716540009620 putative nucleotide binding site [chemical binding]; other site 716540009621 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 716540009622 domain I; other site 716540009623 DNA binding groove [nucleotide binding] 716540009624 phosphate binding site [ion binding]; other site 716540009625 domain II; other site 716540009626 domain III; other site 716540009627 nucleotide binding site [chemical binding]; other site 716540009628 catalytic site [active] 716540009629 domain IV; other site 716540009630 HMMPfam hit to PF01131, DNA topoisomerase, score 5e-171 716540009631 PS00396 Prokaryotic DNA topoisomerase I active site. 716540009632 HMMPfam hit to PF01751, Toprim domain, score 3.4e-33 716540009633 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 716540009634 putative FMN binding site [chemical binding]; other site 716540009635 HMMPfam hit to PF00881, Nitroreductase family, score 1.1e-34 716540009636 protease 4; Provisional; Region: PRK10949 716540009637 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 716540009638 tandem repeat interface [polypeptide binding]; other site 716540009639 oligomer interface [polypeptide binding]; other site 716540009640 active site residues [active] 716540009641 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 716540009642 tandem repeat interface [polypeptide binding]; other site 716540009643 oligomer interface [polypeptide binding]; other site 716540009644 active site residues [active] 716540009645 Signal peptide predicted for EAM_1926 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.624 between residues 47 and 48 716540009646 1 transmembrane helix predicted for EAM_1926 by TMHMM2.0 at aa 21-43 716540009647 HMMPfam hit to PF01343, Peptidase family S49, score 4.5e-49 716540009648 HMMPfam hit to PF01343, Peptidase family S49, score 1.7e-70 716540009649 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 716540009650 active site 716540009651 homodimer interface [polypeptide binding]; other site 716540009652 HMMPfam hit to PF00710, Asparaginase, score 6.4e-137 716540009653 PS00144 Asparaginase / glutaminase active site signature 1. 716540009654 PS00917 Asparaginase / glutaminase active site signature 2. 716540009655 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 716540009656 Isochorismatase family; Region: Isochorismatase; pfam00857 716540009657 catalytic triad [active] 716540009658 metal binding site [ion binding]; metal-binding site 716540009659 conserved cis-peptide bond; other site 716540009660 HMMPfam hit to PF00857, Isochorismatase family, score 1.1e-45 716540009661 Protein of unknown function (DUF1315); Region: DUF1315; cl01215 716540009662 Predicted helix-turn-helix motif with score 1210.000, SD 3.31 at aa 71-92, sequence KSKKQLKEEFGISDETVTRIRL 716540009663 HMMPfam hit to PF07023, Protein of unknown function (DUF1315), score 1.1e-46 716540009664 methionine sulfoxide reductase B; Provisional; Region: PRK00222 716540009665 SelR domain; Region: SelR; pfam01641 716540009666 HMMPfam hit to PF01641, SelR domain, score 4.9e-69 716540009667 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 716540009668 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 716540009669 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 716540009670 HMMPfam hit to PF00044, Glyceraldehyde 3-phosphate dehydrogenase, NA, score 1.7e-100 716540009671 PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site. 716540009672 HMMPfam hit to PF02800, Glyceraldehyde 3-phosphate dehydrogenase, C-, score 2.2e-116 716540009673 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 716540009674 active site 716540009675 phosphate binding residues; other site 716540009676 catalytic residues [active] 716540009677 HMMPfam hit to PF01263, Aldose 1-epimerase, score 4.8e-34 716540009678 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 716540009679 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 716540009680 active site 716540009681 catalytic tetrad [active] 716540009682 HMMPfam hit to PF00248, Aldo/keto reductase family, score 2.5e-54 716540009683 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 716540009684 HMMPfam hit to PF06629, MltA-interacting protein MipA, score 1.5e-71 716540009685 Signal peptide predicted for EAM_1934 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.994 between residues 24 and 25 716540009686 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540009687 PrkA family serine protein kinase; Provisional; Region: PRK15455 716540009688 AAA ATPase domain; Region: AAA_16; pfam13191 716540009689 Walker A motif; other site 716540009690 ATP binding site [chemical binding]; other site 716540009691 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 716540009692 HMMPfam hit to PF08298, PrkA AAA domain, score 2.5e-263 716540009693 PS00017 ATP/GTP-binding site motif A (P-loop). 716540009694 HMMPfam hit to PF06798, PrkA serine protein kinase C-terminal domain, score 1.7e-178 716540009695 hypothetical protein; Provisional; Region: PRK05325 716540009696 HMMPfam hit to PF04285, Protein of unknown function (DUF444), score 3.1e-272 716540009697 Signal peptide predicted for EAM_1939 by SignalP 2.0 HMM (Signal peptide probability 0.910) with cleavage site probability 0.519 between residues 16 and 17 716540009698 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540009699 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 716540009700 TrkA-C domain; Region: TrkA_C; pfam02080 716540009701 Transporter associated domain; Region: CorC_HlyC; smart01091 716540009702 Signal peptide predicted for EAM_1940 by SignalP 2.0 HMM (Signal peptide probability 0.713) with cleavage site probability 0.173 between residues 29 and 30 716540009703 12 transmembrane helices predicted for EAM_1940 by TMHMM2.0 at aa 5-27, 32-54, 61-78, 93-115, 120-142, 187-209, 216-235, 239-261, 273-290, 300-322, 335-357 and 361-383 716540009704 HMMPfam hit to PF00999, Sodium/hydrogen exchanger family, score 3.2e-64 716540009705 HMMPfam hit to PF02080, TrkA-C domain, score 1.5e-09 716540009706 HMMPfam hit to PF03471, Transporter associated domain, score 1.4e-21 716540009707 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 716540009708 Bacterial sugar transferase; Region: Bac_transf; pfam02397 716540009709 Signal peptide predicted for EAM_1941 by SignalP 2.0 HMM (Signal peptide probability 0.839) with cleavage site probability 0.367 between residues 48 and 49 716540009710 5 transmembrane helices predicted for EAM_1941 by TMHMM2.0 at aa 20-42, 62-81, 94-116, 126-145 and 298-320 716540009711 HMMPfam hit to PF02397, Bacterial sugar transferase, score 9.4e-140 716540009712 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540009713 putative substrate translocation pore; other site 716540009714 Major Facilitator Superfamily; Region: MFS_1; pfam07690 716540009715 Signal peptide predicted for EAM_1942 by SignalP 2.0 HMM (Signal peptide probability 0.919) with cleavage site probability 0.450 between residues 30 and 31 716540009716 12 transmembrane helices predicted for EAM_1942 by TMHMM2.0 at aa 7-24, 39-61, 70-92, 97-116, 129-151, 161-178, 206-228, 238-260, 272-294, 304-326, 339-361 and 366-383 716540009717 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 8.1e-43 716540009718 PS00216 Sugar transport proteins signature 1. 716540009719 alanine racemase; Reviewed; Region: dadX; PRK03646 716540009720 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 716540009721 active site 716540009722 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 716540009723 substrate binding site [chemical binding]; other site 716540009724 catalytic residues [active] 716540009725 dimer interface [polypeptide binding]; other site 716540009726 HMMPfam hit to PF00842, Alanine racemase, C-terminal domain, score 3.8e-62 716540009727 HMMPfam hit to PF01168, Alanine racemase, N-terminal domain, score 1.1e-86 716540009728 PS00395 Alanine racemase pyridoxal-phosphate attachment site. 716540009729 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 716540009730 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 716540009731 hydroxyglutarate oxidase; Provisional; Region: PRK11728 716540009732 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 1e-108 716540009733 SpoVR family protein; Provisional; Region: PRK11767 716540009734 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 716540009735 HMMPfam hit to PF04293, SpoVR like protein, score 0 716540009736 fatty acid metabolism regulator; Provisional; Region: PRK04984 716540009737 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 716540009738 DNA-binding site [nucleotide binding]; DNA binding site 716540009739 FadR C-terminal domain; Region: FadR_C; pfam07840 716540009740 HMMPfam hit to PF07840, FadR C-terminal domain, score 3.2e-101 716540009741 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR family, score 3.8e-23 716540009742 PS00043 Bacterial regulatory proteins, gntR family signature. 716540009743 disulfide bond formation protein B; Provisional; Region: PRK01749 716540009744 Signal peptide predicted for EAM_1947 by SignalP 2.0 HMM (Signal peptide probability 0.953) with cleavage site probability 0.888 between residues 24 and 25 716540009745 HMMPfam hit to PF02600, Disulfide bond formation protein DsbB, score 2.5e-65 716540009746 2 transmembrane helices predicted for EAM_1947 by TMHMM2.0 at aa 13-35 and 145-167 716540009747 hypothetical protein; Provisional; Region: PRK05170 716540009748 HMMPfam hit to PF05779, Bacterial protein of unknown function (DUF83, score 7.3e-104 716540009749 hypothetical protein; Provisional; Region: PRK10691 716540009750 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 716540009751 HMMPfam hit to PF01557, Fumarylacetoacetate (FAA) hydrolase fam, score 1.3e-79 716540009752 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 716540009753 HMMPfam hit to PF05166, Family of unknown function (DUF709), score 1.3e-48 716540009754 septum formation inhibitor; Reviewed; Region: minC; PRK03511 716540009755 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 716540009756 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 716540009757 HMMPfam hit to PF05209, Septum formation inhibitor MinC, N-terminal, score 4.6e-37 716540009758 HMMPfam hit to PF03775, Septum formation inhibitor MinC, C-terminal, score 1.9e-56 716540009759 cell division inhibitor MinD; Provisional; Region: PRK10818 716540009760 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 716540009761 Switch I; other site 716540009762 Switch II; other site 716540009763 HMMPfam hit to PF01656, CobQ/CobB/MinD/ParA nucleotide binding domai, score 6.1e-27 716540009764 PS00017 ATP/GTP-binding site motif A (P-loop). 716540009765 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 716540009766 HMMPfam hit to PF03776, Septum formation topological specificity fac, score 6e-51 716540009767 ribonuclease D; Provisional; Region: PRK10829 716540009768 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 716540009769 catalytic site [active] 716540009770 putative active site [active] 716540009771 putative substrate binding site [chemical binding]; other site 716540009772 Helicase and RNase D C-terminal; Region: HRDC; smart00341 716540009773 HMMPfam hit to PF00570, HRDC domain, score 5.3e-17 716540009774 HMMPfam hit to PF01612, 3'-5' exonuclease, score 2.6e-55 716540009775 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 716540009776 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 716540009777 acyl-activating enzyme (AAE) consensus motif; other site 716540009778 putative AMP binding site [chemical binding]; other site 716540009779 putative active site [active] 716540009780 putative CoA binding site [chemical binding]; other site 716540009781 HMMPfam hit to PF00501, AMP-binding enzyme, score 5.1e-127 716540009782 PS00455 AMP-binding domain signature. 716540009783 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 716540009784 Outer membrane lipoprotein Slp family; Region: Slp; cl01164 716540009785 HMMPfam hit to PF03843, Outer membrane lipoprotein Slp family, score 4e-63 716540009786 Signal peptide predicted for EAM_1957 by SignalP 2.0 HMM (Signal peptide probability 0.991) with cleavage site probability 0.322 between residues 29 and 30 716540009787 1 transmembrane helix predicted for EAM_1957 by TMHMM2.0 at aa 7-29 716540009788 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540009789 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 716540009790 Glycoprotease family; Region: Peptidase_M22; pfam00814 716540009791 HMMPfam hit to PF00814, Glycoprotease family, score 1.2e-55 716540009792 1 transmembrane helix predicted for EAM_1958 by TMHMM2.0 at aa 75-97 716540009793 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 716540009794 DEAD/DEAH box helicase; Region: DEAD; pfam00270 716540009795 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 716540009796 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 716540009797 PS00017 ATP/GTP-binding site motif A (P-loop). 716540009798 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 716540009799 homotrimer interaction site [polypeptide binding]; other site 716540009800 putative active site [active] 716540009801 HMMPfam hit to PF01042, Endoribonuclease L-PSP, score 5.5e-26 716540009802 hypothetical protein; Provisional; Region: PRK05114 716540009803 HMMPfam hit to PF03701, Uncharacterised protein family (UPF0181), score 4.6e-25 716540009804 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 716540009805 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 716540009806 chorismate binding enzyme; Region: Chorismate_bind; cl10555 716540009807 HMMPfam hit to PF04715, Anthranilate synthase component I, N, score 1.2e-27 716540009808 HMMPfam hit to PF00425, chorismate binding enzyme, score 9e-125 716540009809 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 716540009810 putative active site [active] 716540009811 putative CoA binding site [chemical binding]; other site 716540009812 nudix motif; other site 716540009813 metal binding site [ion binding]; metal-binding site 716540009814 HMMPfam hit to PF00293, NUDIX domain, score 9.8e-14 716540009815 PS01293 Uncharacterized protein family UPF0035 signature. 716540009816 PS00024 Hemopexin domain signature. 716540009817 L-serine deaminase; Provisional; Region: PRK15023 716540009818 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 716540009819 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 716540009820 HMMPfam hit to PF03315, Serine dehydratase beta chain, score 7.3e-93 716540009821 HMMPfam hit to PF03313, Serine dehydratase alpha chain, score 1.3e-196 716540009822 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 716540009823 FOG: CBS domain [General function prediction only]; Region: COG0517 716540009824 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 716540009825 Transporter associated domain; Region: CorC_HlyC; smart01091 716540009826 HMMPfam hit to PF03471, Transporter associated domain, score 4.8e-15 716540009827 HMMPfam hit to PF00571, CBS domain pair, score 3.1e-18 716540009828 7 transmembrane helices predicted for EAM_1965 by TMHMM2.0 at aa 13-35, 48-70, 85-102, 123-145, 155-172, 185-207 and 212-231 716540009829 HMMPfam hit to PF03741, Integral membrane protein TerC family, score 6e-36 716540009830 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 716540009831 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716540009832 S-adenosylmethionine binding site [chemical binding]; other site 716540009833 HMMPfam hit to PF08241, Methyltransferase domain, score 2e-12 716540009834 HMMPfam hit to PF08242, Methyltransferase domain, score 1.5e-09 716540009835 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 716540009836 DNA-binding site [nucleotide binding]; DNA binding site 716540009837 RNA-binding motif; other site 716540009838 HMMPfam hit to PF00313, 'Cold-shock' DNA-binding domain, score 3.1e-43 716540009839 PS00352 'Cold-shock' DNA-binding domain signature. 716540009840 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 716540009841 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 716540009842 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 716540009843 YebO-like protein; Region: YebO; pfam13974 716540009844 Signal peptide predicted for EAM_1970 by SignalP 2.0 HMM (Signal peptide probability 0.774) with cleavage site probability 0.259 between residues 38 and 39 716540009845 1 transmembrane helix predicted for EAM_1970 by TMHMM2.0 at aa 10-32 716540009846 YobH-like protein; Region: YobH; pfam13996 716540009847 Signal peptide predicted for EAM_1971 by SignalP 2.0 HMM (Signal peptide probability 0.964) with cleavage site probability 0.279 between residues 22 and 23 716540009848 1 transmembrane helix predicted for EAM_1971 by TMHMM2.0 at aa 7-29 716540009849 heat shock protein HtpX; Provisional; Region: PRK05457 716540009850 HMMPfam hit to PF01435, Peptidase family M48, score 1.2e-38 716540009851 PS00017 ATP/GTP-binding site motif A (P-loop). 716540009852 4 transmembrane helices predicted for EAM_1972 by TMHMM2.0 at aa 5-27, 32-54, 158-180 and 195-217 716540009853 HMMPfam hit to PF06509, HtpX N-terminus, score 1.1e-50 716540009854 Signal peptide predicted for EAM_1972 by SignalP 2.0 HMM (Signal peptide probability 0.990) with cleavage site probability 0.558 between residues 63 and 64 716540009855 carboxy-terminal protease; Provisional; Region: PRK11186 716540009856 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 716540009857 protein binding site [polypeptide binding]; other site 716540009858 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 716540009859 Catalytic dyad [active] 716540009860 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 716540009861 HMMPfam hit to PF03572, Peptidase family S41, score 1.2e-64 716540009862 HMMPfam hit to PF00595, PDZ domain (Also known as DHR or GLGF), score 6.4e-14 716540009863 Signal peptide predicted for EAM_1973 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 21 and 22 716540009864 ProP expression regulator; Provisional; Region: PRK04950 716540009865 ProQ/FINO family; Region: ProQ; pfam04352 716540009866 HMMPfam hit to PF04352, ProQ activator of osmoprotectant transporter, score 2.8e-80 716540009867 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 716540009868 GAF domain; Region: GAF_2; pfam13185 716540009869 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 716540009870 Paraquat-inducible protein A; Region: PqiA; pfam04403 716540009871 Paraquat-inducible protein A; Region: PqiA; pfam04403 716540009872 HMMPfam hit to PF04403, Paraquat-inducible protein A, score 1.8e-71 716540009873 8 transmembrane helices predicted for EAM_1976 by TMHMM2.0 at aa 64-86, 114-136, 157-179, 183-205, 263-285, 311-333, 354-373 and 378-400 716540009874 HMMPfam hit to PF04403, Paraquat-inducible protein A, score 1e-92 716540009875 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 716540009876 mce related protein; Region: MCE; pfam02470 716540009877 mce related protein; Region: MCE; pfam02470 716540009878 mce related protein; Region: MCE; pfam02470 716540009879 mce related protein; Region: MCE; pfam02470 716540009880 mce related protein; Region: MCE; pfam02470 716540009881 1 transmembrane helix predicted for EAM_1977 by TMHMM2.0 at aa 20-39 716540009882 HMMPfam hit to PF02470, mce related protein, score 5.9e-30 716540009883 HMMPfam hit to PF02470, mce related protein, score 2.4e-05 716540009884 HMMPfam hit to PF02470, mce related protein, score 2.4e-10 716540009885 HMMPfam hit to PF02470, mce related protein, score 0.0018 716540009886 HMMPfam hit to PF02470, mce related protein, score 0.00015 716540009887 HMMPfam hit to PF02470, mce related protein, score 8.3e-21 716540009888 HMMPfam hit to PF02470, mce related protein, score 7.7e-17 716540009889 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 716540009890 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 716540009891 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 716540009892 PS01153 NOL1/NOP2/sun family signature. 716540009893 HMMPfam hit to PF01189, NOL1/NOP2/sun family, score 1.9e-46 716540009894 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716540009895 Domain of unknown function DUF20; Region: UPF0118; pfam01594 716540009896 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 716540009897 Signal peptide predicted for EAM_1981 by SignalP 2.0 HMM (Signal peptide probability 0.926) with cleavage site probability 0.890 between residues 36 and 37 716540009898 HMMPfam hit to PF01594, Domain of unknown function DUF20, score 2.3e-48 716540009899 7 transmembrane helices predicted for EAM_1981 by TMHMM2.0 at aa 10-43, 64-86, 154-176, 216-238, 248-270, 277-299 and 321-343 716540009900 Membrane protein of unknown function (DUF340); Region: DUF340; pfam03956 716540009901 8 transmembrane helices predicted for EAM_1982 by TMHMM2.0 at aa 4-21, 33-55, 65-87, 100-122, 137-155, 162-181, 191-213 and 273-295 716540009902 HMMPfam hit to PF03956, Membrane protein of unknown function (DUF340, score 1e-22 716540009903 Signal peptide predicted for EAM_1982 by SignalP 2.0 HMM (Signal peptide probability 0.957) with cleavage site probability 0.615 between residues 22 and 23 716540009904 Biofilm formation and stress response factor; Region: BsmA; pfam10014 716540009905 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 716540009906 4 transmembrane helices predicted for EAM_1984 by TMHMM2.0 at aa 13-35, 55-77, 90-112 and 313-335 716540009907 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 716540009908 Signal peptide predicted for EAM_1985 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.990 between residues 19 and 20 716540009909 3 transmembrane helices predicted for EAM_1986 by TMHMM2.0 at aa 23-45, 80-102 and 123-140 716540009910 Signal peptide predicted for EAM_1988 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.593 between residues 23 and 24 716540009911 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 716540009912 HMMPfam hit to PF06440, DNA polymerase III, theta subunit, score 1.9e-49 716540009913 exodeoxyribonuclease X; Provisional; Region: PRK07983 716540009914 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 716540009915 active site 716540009916 catalytic site [active] 716540009917 substrate binding site [chemical binding]; other site 716540009918 HMMPfam hit to PF00929, Exonuclease, score 5.3e-24 716540009919 protease 2; Provisional; Region: PRK10115 716540009920 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 716540009921 HMMPfam hit to PF00326, Prolyl oligopeptidase family, score 8.2e-101 716540009922 HMMPfam hit to PF02897, Prolyl oligopeptidase, N-terminal beta, score 8.4e-131 716540009923 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 716540009924 HMMPfam hit to PF01261, Xylose isomerase-like TIM barrel, score 1.1e-27 716540009925 YebG protein; Region: YebG; pfam07130 716540009926 HMMPfam hit to PF07130, YebG protein, score 1.7e-45 716540009927 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 716540009928 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 716540009929 ATP-grasp domain; Region: ATP-grasp; pfam02222 716540009930 HMMPfam hit to PF02222, ATP-grasp domain, score 2.1e-93 716540009931 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 716540009932 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 716540009933 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 716540009934 HMMPfam hit to PF02781, Glucose-6-phosphate dehydrogenase, C-termina, score 7.9e-197 716540009935 HMMPfam hit to PF00479, Glucose-6-phosphate dehydrogenase, NAD bindi, score 1e-93 716540009936 PS00069 Glucose-6-phosphate dehydrogenase active site. 716540009937 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 716540009938 pyruvate kinase; Provisional; Region: PRK05826 716540009939 active site 716540009940 domain interfaces; other site 716540009941 HMMPfam hit to PF00224, Pyruvate kinase, barrel domain, score 1.5e-208 716540009942 PS00110 Pyruvate kinase active site signature. 716540009943 HMMPfam hit to PF02887, Pyruvate kinase, alpha/beta domain, score 1e-55 716540009944 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 716540009945 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540009946 putative substrate translocation pore; other site 716540009947 12 transmembrane helices predicted for EAM_1997 by TMHMM2.0 at aa 13-32, 52-71, 83-102, 107-129, 141-163, 173-190, 224-246, 256-275, 288-307, 312-334, 347-366 and 376-398 716540009948 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.6e-28 716540009949 PS00216 Sugar transport proteins signature 1. 716540009950 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 716540009951 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 716540009952 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 716540009953 putative acyl-acceptor binding pocket; other site 716540009954 HMMPfam hit to PF03279, Bacterial lipid A biosynthesis acyltr, score 1e-131 716540009955 1 transmembrane helix predicted for EAM_1998 by TMHMM2.0 at aa 20-42 716540009956 putative peptidase; Provisional; Region: PRK11649 716540009957 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 716540009958 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 716540009959 Peptidase family M23; Region: Peptidase_M23; pfam01551 716540009960 HMMPfam hit to PF01551, Peptidase family M23, score 6.5e-55 716540009961 HMMPfam hit to PF04225, Opacity-associated protein A LysM-like, score 0.00035 716540009962 HMMPfam hit to PF01476, LysM domain, score 0.00032 716540009963 HMMPfam hit to PF08525, Opacity-associated protein A N-terminal, score 4e-05 716540009964 1 transmembrane helix predicted for EAM_1999 by TMHMM2.0 at aa 21-40 716540009965 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 716540009966 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 716540009967 metal binding site [ion binding]; metal-binding site 716540009968 HMMPfam hit to PF01297, Periplasmic solute binding protein family, score 1.9e-24 716540009969 Signal peptide predicted for EAM_2000 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 27 and 28 716540009970 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 716540009971 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 716540009972 HMMPfam hit to PF00005, ABC transporter, score 1.2e-46 716540009973 PS00017 ATP/GTP-binding site motif A (P-loop). 716540009974 PS00211 ABC transporters family signature. 716540009975 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 716540009976 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 716540009977 ABC-ATPase subunit interface; other site 716540009978 dimer interface [polypeptide binding]; other site 716540009979 putative PBP binding regions; other site 716540009980 HMMPfam hit to PF00950, ABC 3 transport family, score 2.3e-110 716540009981 Signal peptide predicted for EAM_2002 by SignalP 2.0 HMM (Signal peptide probability 0.970) with cleavage site probability 0.892 between residues 18 and 19 716540009982 7 transmembrane helices predicted for EAM_2002 by TMHMM2.0 at aa 5-27, 42-73, 85-107, 127-149, 170-192, 212-234 and 239-256 716540009983 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 716540009984 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716540009985 Walker A motif; other site 716540009986 ATP binding site [chemical binding]; other site 716540009987 Walker B motif; other site 716540009988 arginine finger; other site 716540009989 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 716540009990 HMMPfam hit to PF05491, Holliday junction DNA helicase ruvB C-termin, score 9e-55 716540009991 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 1.1e-34 716540009992 HMMPfam hit to PF07728, ATPase family associated with various cellul, score 4.2e-05 716540009993 PS00017 ATP/GTP-binding site motif A (P-loop). 716540009994 HMMPfam hit to PF05496, Holliday junction DNA helicase ruvB N-termin, score 1.5e-26 716540009995 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 716540009996 RuvA N terminal domain; Region: RuvA_N; pfam01330 716540009997 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 716540009998 HMMPfam hit to PF07499, RuvA, C-terminal domain, score 2.6e-17 716540009999 HMMPfam hit to PF01330, RuvA N terminal domain, score 7.2e-28 716540010000 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 716540010001 active site 716540010002 putative DNA-binding cleft [nucleotide binding]; other site 716540010003 dimer interface [polypeptide binding]; other site 716540010004 HMMPfam hit to PF02075, Crossover junction endodeoxyribonuclease Ruv, score 1.7e-102 716540010005 PS01321 Crossover junction endodeoxyribonuclease ruvC signature. 716540010006 hypothetical protein; Validated; Region: PRK00110 716540010007 HMMPfam hit to PF01709, Domain of unknown function DUF28, score 9.7e-144 716540010008 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 716540010009 nudix motif; other site 716540010010 HMMPfam hit to PF00293, NUDIX domain, score 1.8e-24 716540010011 PS00893 mutT domain signature. 716540010012 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 716540010013 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 716540010014 dimer interface [polypeptide binding]; other site 716540010015 anticodon binding site; other site 716540010016 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 716540010017 homodimer interface [polypeptide binding]; other site 716540010018 motif 1; other site 716540010019 active site 716540010020 motif 2; other site 716540010021 GAD domain; Region: GAD; pfam02938 716540010022 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 716540010023 active site 716540010024 motif 3; other site 716540010025 HMMPfam hit to PF00152, tRNA synthetases class II (D, K and N), score 4.6e-213 716540010026 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 716540010027 HMMPfam hit to PF02938, GAD domain, score 2.2e-43 716540010028 HMMPfam hit to PF00587, tRNA synthetase class II core domain (G,, score 0.0049 716540010029 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 716540010030 HMMPfam hit to PF01336, OB-fold nucleic acid binding domain, score 1.5e-27 716540010031 hypothetical protein; Provisional; Region: PRK10302 716540010032 HMMPfam hit to PF01904, Protein of unknown function DUF72, score 1.5e-72 716540010033 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 716540010034 3 transmembrane helices predicted for EAM_2010 by TMHMM2.0 at aa 2-24, 70-92 and 105-127 716540010035 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716540010036 S-adenosylmethionine binding site [chemical binding]; other site 716540010037 HMMPfam hit to PF08241, Methyltransferase domain, score 2.4e-15 716540010038 HMMPfam hit to PF08242, Methyltransferase domain, score 8.7e-13 716540010039 Methyltransferase domain; Region: Methyltransf_31; pfam13847 716540010040 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716540010041 S-adenosylmethionine binding site [chemical binding]; other site 716540010042 HMMPfam hit to PF08003, Protein of unknown function (DUF1698), score 3.6e-236 716540010043 HMMPfam hit to PF08241, Methyltransferase domain, score 1.8e-08 716540010044 HMMPfam hit to PF08242, Methyltransferase domain, score 2.9e-06 716540010045 copper homeostasis protein CutC; Provisional; Region: PRK11572 716540010046 HMMPfam hit to PF03932, CutC family, score 6e-97 716540010047 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 716540010048 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 716540010049 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716540010050 homodimer interface [polypeptide binding]; other site 716540010051 catalytic residue [active] 716540010052 HMMPfam hit to PF00155, Aminotransferase class I and II, score 9.6e-14 716540010053 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 716540010054 putative metal binding site [ion binding]; other site 716540010055 HMMPfam hit to PF06185, YecM protein, score 3.8e-87 716540010056 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 716540010057 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 716540010058 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 716540010059 active site 716540010060 HIGH motif; other site 716540010061 KMSK motif region; other site 716540010062 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 716540010063 tRNA binding surface [nucleotide binding]; other site 716540010064 anticodon binding site; other site 716540010065 HMMPfam hit to PF03485, Arginyl tRNA synthetase N terminal do, score 1.8e-28 716540010066 HMMPfam hit to PF00750, tRNA synthetases class I (R), score 7e-194 716540010067 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 716540010068 HMMPfam hit to PF05746, DALR anticodon binding domain, score 3.7e-51 716540010069 Flagellar protein FlhE; Region: FlhE; pfam06366 716540010070 HMMPfam hit to PF06366, Flagellar protein FlhE, score 3.7e-50 716540010071 Signal peptide predicted for EAM_2019 by SignalP 2.0 HMM (Signal peptide probability 0.969) with cleavage site probability 0.537 between residues 17 and 18 716540010072 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 716540010073 FHIPEP family; Region: FHIPEP; pfam00771 716540010074 HMMPfam hit to PF00771, FHIPEP family, score 0 716540010075 7 transmembrane helices predicted for EAM_2020 by TMHMM2.0 at aa 21-38, 42-64, 76-98, 118-140, 209-231, 251-273 and 294-327 716540010076 PS00994 Bacterial export FHIPEP family signature. 716540010077 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK12468 716540010078 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 716540010079 HMMPfam hit to PF01312, FlhB HrpN YscU SpaS Family, score 9.4e-164 716540010080 4 transmembrane helices predicted for EAM_2021 by TMHMM2.0 at aa 33-55, 96-118, 146-165 and 180-202 716540010081 chemotaxis regulator CheZ; Provisional; Region: PRK11166 716540010082 HMMPfam hit to PF04344, Chemotaxis phosphatase, CheZ, score 2.3e-114 716540010083 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 716540010084 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716540010085 active site 716540010086 phosphorylation site [posttranslational modification] 716540010087 intermolecular recognition site; other site 716540010088 dimerization interface [polypeptide binding]; other site 716540010089 HMMPfam hit to PF00072, Response regulator receiver domain, score 6.3e-42 716540010090 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 716540010091 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716540010092 active site 716540010093 phosphorylation site [posttranslational modification] 716540010094 intermolecular recognition site; other site 716540010095 dimerization interface [polypeptide binding]; other site 716540010096 CheB methylesterase; Region: CheB_methylest; pfam01339 716540010097 HMMPfam hit to PF01339, CheB methylesterase, score 9.8e-122 716540010098 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.1e-31 716540010099 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 716540010100 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 716540010101 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716540010102 S-adenosylmethionine binding site [chemical binding]; other site 716540010103 HMMPfam hit to PF01739, CheR methyltransferase, SAM binding d, score 8.3e-86 716540010104 HMMPfam hit to PF08242, Methyltransferase domain, score 0.0014 716540010105 HMMPfam hit to PF03705, CheR methyltransferase, all-alpha dom, score 1e-14 716540010106 methyl-accepting protein IV; Provisional; Region: PRK09793 716540010107 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 716540010108 dimer interface [polypeptide binding]; other site 716540010109 ligand binding site [chemical binding]; other site 716540010110 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 716540010111 dimerization interface [polypeptide binding]; other site 716540010112 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 716540010113 dimer interface [polypeptide binding]; other site 716540010114 putative CheW interface [polypeptide binding]; other site 716540010115 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 2.7e-108 716540010116 PS00538 Bacterial chemotaxis sensory transducers signature. 716540010117 HMMPfam hit to PF00672, HAMP domain, score 2.8e-14 716540010118 2 transmembrane helices predicted for EAM_2026 by TMHMM2.0 at aa 10-32 and 190-209 716540010119 HMMPfam hit to PF02203, Tar ligand binding domain homologue, score 2e-23 716540010120 Signal peptide predicted for EAM_2026 by SignalP 2.0 HMM (Signal peptide probability 0.971) with cleavage site probability 0.426 between residues 34 and 35 716540010121 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 716540010122 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 716540010123 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 716540010124 dimer interface [polypeptide binding]; other site 716540010125 ligand binding site [chemical binding]; other site 716540010126 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 716540010127 dimerization interface [polypeptide binding]; other site 716540010128 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 716540010129 dimer interface [polypeptide binding]; other site 716540010130 putative CheW interface [polypeptide binding]; other site 716540010131 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 2.2e-118 716540010132 PS00538 Bacterial chemotaxis sensory transducers signature. 716540010133 HMMPfam hit to PF00672, HAMP domain, score 2e-15 716540010134 2 transmembrane helices predicted for EAM_2028 by TMHMM2.0 at aa 7-29 and 192-214 716540010135 Signal peptide predicted for EAM_2028 by SignalP 2.0 HMM (Signal peptide probability 0.965) with cleavage site probability 0.467 between residues 25 and 26 716540010136 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 716540010137 putative CheA interaction surface; other site 716540010138 HMMPfam hit to PF01584, CheW-like domain, score 1.1e-34 716540010139 chemotaxis protein CheA; Provisional; Region: PRK10547 716540010140 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 716540010141 putative binding surface; other site 716540010142 active site 716540010143 CheY binding; Region: CheY-binding; pfam09078 716540010144 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 716540010145 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716540010146 ATP binding site [chemical binding]; other site 716540010147 Mg2+ binding site [ion binding]; other site 716540010148 G-X-G motif; other site 716540010149 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 716540010150 HMMPfam hit to PF01584, CheW-like domain, score 1.2e-26 716540010151 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 2e-29 716540010152 HMMPfam hit to PF02895, Signal transducing histidine kinase, hom, score 5.3e-27 716540010153 HMMPfam hit to PF01627, Hpt domain, score 2.5e-15 716540010154 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 716540010155 flagellar motor protein MotB; Validated; Region: motB; PRK09041 716540010156 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 716540010157 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 716540010158 ligand binding site [chemical binding]; other site 716540010159 HMMPfam hit to PF00691, OmpA family, score 7.9e-31 716540010160 1 transmembrane helix predicted for EAM_2031 by TMHMM2.0 at aa 28-50 716540010161 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 716540010162 flagellar motor protein MotA; Validated; Region: PRK09110 716540010163 4 transmembrane helices predicted for EAM_2032 by TMHMM2.0 at aa 2-24, 34-51, 171-190 and 205-227 716540010164 PS01307 Flagellar motor protein motA family signature. 716540010165 transcriptional activator FlhC; Provisional; Region: PRK12722 716540010166 HMMPfam hit to PF05280, Flagellar transcriptional activator (FlhC), score 5.9e-148 716540010167 transcriptional activator FlhD; Provisional; Region: PRK02909 716540010168 HMMPfam hit to PF05247, Flagellar transcriptional activator (FlhD), score 6.7e-67 716540010169 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 716540010170 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 716540010171 active site 716540010172 homotetramer interface [polypeptide binding]; other site 716540010173 HMMPfam hit to PF00982, Glycosyltransferase family, score 4.5e-178 716540010174 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 716540010175 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 716540010176 HMMPfam hit to PF08282, haloacid dehalogenase-like hydrolase, score 0.0013 716540010177 HMMPfam hit to PF02358, Trehalose-phosphatase, score 1.1e-56 716540010178 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 716540010179 Signal peptide predicted for EAM_2038 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.328 between residues 50 and 51 716540010180 HMMPfam hit to PF06912, Protein of unknown function (DUF1275), score 4.2e-20 716540010181 6 transmembrane helices predicted for EAM_2038 by TMHMM2.0 at aa 20-42, 68-90, 97-119, 154-176, 189-211 and 216-238 716540010182 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 716540010183 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 716540010184 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 716540010185 Catalytic site [active] 716540010186 HMMPfam hit to PF00717, Peptidase S24-like, score 5.3e-15 716540010187 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 716540010188 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 716540010189 active site 716540010190 DNA binding site [nucleotide binding] 716540010191 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 716540010192 HMMPfam hit to PF00817, impB/mucB/samB family, score 1.5e-147 716540010193 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 716540010194 dimer interface [polypeptide binding]; other site 716540010195 active site 716540010196 Schiff base residues; other site 716540010197 HMMPfam hit to PF00490, Delta-aminolevulinic acid dehydratase, score 3.1e-216 716540010198 PS00169 Delta-aminolevulinic acid dehydratase active site. 716540010199 Predicted flavoprotein [General function prediction only]; Region: COG0431 716540010200 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 716540010201 Signal peptide predicted for EAM_2042 by SignalP 2.0 HMM (Signal peptide probability 0.950) with cleavage site probability 0.290 between residues 23 and 24 716540010202 HMMPfam hit to PF03358, NADPH-dependent FMN reductase, score 8.9e-34 716540010203 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 716540010204 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 716540010205 Signal peptide predicted for EAM_2043 by SignalP 2.0 HMM (Signal peptide probability 0.715) with cleavage site probability 0.279 between residues 20 and 21 716540010206 11 transmembrane helices predicted for EAM_2043 by TMHMM2.0 at aa 5-24, 31-50, 65-82, 95-117, 167-189, 196-218, 233-264, 327-344, 348-367, 380-399 and 414-436 716540010207 HMMPfam hit to PF00999, Sodium/hydrogen exchanger family, score 2.2e-21 716540010208 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 716540010209 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 716540010210 10 transmembrane helices predicted for EAM_2044 by TMHMM2.0 at aa 13-35, 45-64, 85-107, 117-139, 174-196, 230-252, 294-316, 331-353, 365-387 and 392-409 716540010211 HMMPfam hit to PF01943, Polysaccharide biosynthesis protein, score 3.9e-40 716540010212 PS00017 ATP/GTP-binding site motif A (P-loop). 716540010213 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 716540010214 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 716540010215 active site 716540010216 HMMPfam hit to PF00535, Glycosyl transferase family, score 4.8e-26 716540010217 PS00079 Multicopper oxidases signature 1. 716540010218 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 716540010219 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 716540010220 Na binding site [ion binding]; other site 716540010221 12 transmembrane helices predicted for EAM_2047 by TMHMM2.0 at aa 39-61, 66-88, 105-127, 147-166, 168-190, 205-227, 240-262, 277-299, 336-353, 363-385, 405-424 and 444-461 716540010222 HMMPfam hit to PF02133, Permease for cytosine/purines, uracil,, score 1.4e-29 716540010223 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 716540010224 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 716540010225 NAD(P) binding site [chemical binding]; other site 716540010226 catalytic residues [active] 716540010227 HMMPfam hit to PF00171, Aldehyde dehydrogenase family, score 2.7e-217 716540010228 PS00070 Aldehyde dehydrogenases cysteine active site. 716540010229 PS00687 Aldehyde dehydrogenases glutamic acid active site. 716540010230 PS00017 ATP/GTP-binding site motif A (P-loop). 716540010231 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 716540010232 EamA-like transporter family; Region: EamA; pfam00892 716540010233 EamA-like transporter family; Region: EamA; pfam00892 716540010234 Signal peptide predicted for EAM_2049 by SignalP 2.0 HMM (Signal peptide probability 0.659) with cleavage site probability 0.293 between residues 22 and 23 716540010235 10 transmembrane helices predicted for EAM_2049 by TMHMM2.0 at aa 5-27, 32-51, 58-80, 85-107, 114-131, 135-157, 164-186, 201-223, 230-252 and 262-279 716540010236 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 4.3e-20 716540010237 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 1.5e-15 716540010238 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 716540010239 HMMPfam hit to PF06192, Cytoplasmic chaperone TorD, score 4.9e-44 716540010240 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 716540010241 alkaline phosphatase; Provisional; Region: PRK10518 716540010242 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 716540010243 dimer interface [polypeptide binding]; other site 716540010244 active site 716540010245 HMMPfam hit to PF00245, Alkaline phosphatase, score 1.8e-125 716540010246 PS00017 ATP/GTP-binding site motif A (P-loop). 716540010247 PS00123 Alkaline phosphatase active site. 716540010248 Signal peptide predicted for EAM_2052 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 21 and 22 716540010249 HMMPfam hit to PF00881, Nitroreductase family, score 6.7e-28 716540010250 hypothetical protein; Provisional; Region: PRK10536 716540010251 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 716540010252 HMMPfam hit to PF02562, PhoH-like protein, score 2.4e-133 716540010253 PS00017 ATP/GTP-binding site motif A (P-loop). 716540010254 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 716540010255 formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811 716540010256 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 716540010257 HMMPfam hit to PF04261, Dyp-type peroxidase family, score 1.5e-165 716540010258 Signal peptide predicted for EAM_2057 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.580 between residues 37 and 38 716540010259 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540010260 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 716540010261 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 716540010262 Imelysin; Region: Peptidase_M75; pfam09375 716540010263 HMMPfam hit to PF04302, Protein of unknown function (DUF451), score 8.2e-153 716540010264 Signal peptide predicted for EAM_2058 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 26 and 27 716540010265 Iron permease FTR1 family; Region: FTR1; cl00475 716540010266 HMMPfam hit to PF03239, Iron permease FTR1 family, score 3.1e-97 716540010267 6 transmembrane helices predicted for EAM_2059 by TMHMM2.0 at aa 34-56, 71-89, 119-141, 151-173, 180-202 and 248-270 716540010268 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 716540010269 Na binding site [ion binding]; other site 716540010270 12 transmembrane helices predicted for EAM_2060 by TMHMM2.0 at aa 7-26, 66-88, 125-147, 162-184, 191-213, 233-252, 273-295, 329-351, 372-389, 399-421, 428-450 and 455-472 716540010271 HMMPfam hit to PF00474, Sodium:solute symporter family, score 4.6e-192 716540010272 PS00456 Sodium:solute symporter family signature 1. 716540010273 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 716540010274 Predicted transcriptional regulator [Transcription]; Region: COG3905 716540010275 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 716540010276 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 716540010277 Glutamate binding site [chemical binding]; other site 716540010278 NAD binding site [chemical binding]; other site 716540010279 catalytic residues [active] 716540010280 HMMPfam hit to PF01619, Proline dehydrogenase, score 1.1e-182 716540010281 HMMPfam hit to PF00171, Aldehyde dehydrogenase family, score 1.2e-106 716540010282 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 716540010283 PS00687 Aldehyde dehydrogenases glutamic acid active site. 716540010284 PS00070 Aldehyde dehydrogenases cysteine active site. 716540010285 Predicted membrane protein [Function unknown]; Region: COG4763 716540010286 Acyltransferase family; Region: Acyl_transf_3; pfam01757 716540010287 10 transmembrane helices predicted for EAM_2062 by TMHMM2.0 at aa 20-42, 57-78, 91-113, 136-158, 165-182, 197-214, 221-238, 243-260, 280-299 and 314-336 716540010288 HMMPfam hit to PF01757, Acyltransferase family, score 9.1e-18 716540010289 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 716540010290 HMMPfam hit to PF02899, Phage integrase, N-terminal SAM-like d, score 0.00032 716540010291 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 716540010292 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 716540010293 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 716540010294 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 716540010295 DNA binding residues [nucleotide binding] 716540010296 HMMPfam hit to PF04545, Sigma-70, region, score 5.1e-20 716540010297 HMMPfam hit to PF08281, Sigma-70, region, score 1.9e-10 716540010298 PS00716 Sigma-70 factors family signature 2. 716540010299 Predicted helix-turn-helix motif with score 1242.000, SD 3.42 at aa 205-226, sequence LNLKEIGAVLEVGESRVSQLHS 716540010300 HMMPfam hit to PF04539, Sigma-70 region, score 1e-15 716540010301 HMMPfam hit to PF04542, Sigma-70 region, score 1.4e-18 716540010302 PS00715 Sigma-70 factors family signature 1. 716540010303 HNH endonuclease; Region: HNH_2; pfam13391 716540010304 flagellin; Provisional; Region: PRK12802 716540010305 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 716540010306 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 716540010307 HMMPfam hit to PF00700, Bacterial flagellin C-terminus, score 5.7e-37 716540010308 HMMPfam hit to PF00669, Bacterial flagellin N-terminus, score 2.9e-72 716540010309 flagellar capping protein; Reviewed; Region: fliD; PRK08032 716540010310 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 716540010311 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 716540010312 HMMPfam hit to PF02465, Flagellar hook-associated protein, score 3.9e-27 716540010313 Predicted helix-turn-helix motif with score 987.000, SD 2.55 at aa 86-107, sequence TTATATAGKYNISVSALAKAQT 716540010314 HMMPfam hit to PF07196, Flagellin hook IN motif, score 8.2e-11 716540010315 HMMPfam hit to PF07195, Flagellar hook-associated protein, score 1.7e-61 716540010316 flagellar protein FliS; Validated; Region: fliS; PRK05685 716540010317 HMMPfam hit to PF02561, Flagellar protein FliS, score 1.9e-43 716540010318 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 716540010319 HMMPfam hit to PF05400, Flagellar protein FliT, score 1.1e-32 716540010320 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 716540010321 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 716540010322 active site 716540010323 Na/Ca binding site [ion binding]; other site 716540010324 catalytic site [active] 716540010325 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 716540010326 HMMPfam hit to PF00128, Alpha amylase, catalytic domain, score 1.4e-70 716540010327 lipoprotein; Provisional; Region: PRK10397 716540010328 Signal peptide predicted for EAM_2072 by SignalP 2.0 HMM (Signal peptide probability 0.742) with cleavage site probability 0.290 between residues 18 and 19 716540010329 1 transmembrane helix predicted for EAM_2073 by TMHMM2.0 at aa 73-95 716540010330 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 716540010331 hypothetical protein; Provisional; Region: PRK10062 716540010332 HMMPfam hit to PF05661, Protein of unknown function (DUF808), score 5e-173 716540010333 5 transmembrane helices predicted for EAM_2076 by TMHMM2.0 at aa 76-98, 150-169, 173-195, 230-252 and 272-294 716540010334 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 716540010335 additional DNA contacts [nucleotide binding]; other site 716540010336 mismatch recognition site; other site 716540010337 active site 716540010338 zinc binding site [ion binding]; other site 716540010339 DNA intercalation site [nucleotide binding]; other site 716540010340 HMMPfam hit to PF03852, DNA mismatch endonuclease Vsr, score 1.4e-37 716540010341 DNA cytosine methylase; Provisional; Region: PRK10458 716540010342 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 716540010343 cofactor binding site; other site 716540010344 DNA binding site [nucleotide binding] 716540010345 substrate interaction site [chemical binding]; other site 716540010346 HMMPfam hit to PF00145, C-5 cytosine-specific DNA methylase, score 2.6e-83 716540010347 PS00094 C-5 cytosine-specific DNA methylases active site. 716540010348 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 716540010349 HMMPfam hit to PF02677, Uncharacterized BCR, COG1636, score 5.1e-128 716540010350 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 716540010351 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 716540010352 Zn2+ binding site [ion binding]; other site 716540010353 Mg2+ binding site [ion binding]; other site 716540010354 HMMPfam hit to PF01966, HD domain, score 3.5e-10 716540010355 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 716540010356 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 716540010357 HMMPfam hit to PF06167, Protein of unknown function (DUF980), score 1.2e-116 716540010358 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 716540010359 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 716540010360 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 716540010361 heme binding site [chemical binding]; other site 716540010362 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 716540010363 heme binding site [chemical binding]; other site 716540010364 HMMPfam hit to PF00141, Peroxidase, score 1.6e-80 716540010365 PS00017 ATP/GTP-binding site motif A (P-loop). 716540010366 HMMPfam hit to PF00141, Peroxidase, score 4.5e-97 716540010367 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 716540010368 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 716540010369 metal binding site [ion binding]; metal-binding site 716540010370 Signal peptide predicted for EAM_2087 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 26 and 27 716540010371 1 transmembrane helix predicted for EAM_2087 by TMHMM2.0 at aa 7-26 716540010372 HMMPfam hit to PF01297, Periplasmic solute binding protein family, score 2.8e-117 716540010373 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 716540010374 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 716540010375 HMMPfam hit to PF00005, ABC transporter, score 1.9e-51 716540010376 PS00017 ATP/GTP-binding site motif A (P-loop). 716540010377 PS00211 ABC transporters family signature. 716540010378 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 716540010379 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 716540010380 ABC-ATPase subunit interface; other site 716540010381 dimer interface [polypeptide binding]; other site 716540010382 putative PBP binding regions; other site 716540010383 HMMPfam hit to PF00950, ABC 3 transport family, score 2e-109 716540010384 7 transmembrane helices predicted for EAM_2089 by TMHMM2.0 at aa 15-37, 50-72, 92-114, 121-150, 182-204, 217-239 and 244-266 716540010385 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 716540010386 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 716540010387 ABC-ATPase subunit interface; other site 716540010388 dimer interface [polypeptide binding]; other site 716540010389 putative PBP binding regions; other site 716540010390 HMMPfam hit to PF00950, ABC 3 transport family, score 2.1e-96 716540010391 8 transmembrane helices predicted for EAM_2090 by TMHMM2.0 at aa 20-42, 62-84, 96-115, 130-152, 172-194, 199-216, 223-245 and 250-267 716540010392 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 716540010393 active site 716540010394 ATP binding site [chemical binding]; other site 716540010395 substrate binding site [chemical binding]; other site 716540010396 hypothetical protein; Provisional; Region: PRK06185 716540010397 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 716540010398 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 716540010399 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 716540010400 HMMPfam hit to PF01494, FAD binding domain, score 2e-49 716540010401 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 0.00039 716540010402 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 716540010403 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 716540010404 intersubunit interface [polypeptide binding]; other site 716540010405 Signal peptide predicted for EAM_2096 by SignalP 2.0 HMM (Signal peptide probability 0.910) with cleavage site probability 0.305 between residues 24 and 25 716540010406 HMMPfam hit to PF01497, Periplasmic binding protein, score 2e-05 716540010407 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 716540010408 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 716540010409 Walker A/P-loop; other site 716540010410 ATP binding site [chemical binding]; other site 716540010411 Q-loop/lid; other site 716540010412 ABC transporter signature motif; other site 716540010413 Walker B; other site 716540010414 D-loop; other site 716540010415 H-loop/switch region; other site 716540010416 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 716540010417 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 716540010418 Walker A/P-loop; other site 716540010419 ATP binding site [chemical binding]; other site 716540010420 Q-loop/lid; other site 716540010421 ABC transporter signature motif; other site 716540010422 Walker B; other site 716540010423 D-loop; other site 716540010424 H-loop/switch region; other site 716540010425 HMMPfam hit to PF00005, ABC transporter, score 2.4e-32 716540010426 PS00211 ABC transporters family signature. 716540010427 PS00017 ATP/GTP-binding site motif A (P-loop). 716540010428 HMMPfam hit to PF00005, ABC transporter, score 1.9e-30 716540010429 PS00017 ATP/GTP-binding site motif A (P-loop). 716540010430 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 716540010431 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540010432 dimer interface [polypeptide binding]; other site 716540010433 conserved gate region; other site 716540010434 putative PBP binding loops; other site 716540010435 ABC-ATPase subunit interface; other site 716540010436 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 4.5e-20 716540010437 6 transmembrane helices predicted for EAM_2098 by TMHMM2.0 at aa 12-29, 74-96, 103-125, 130-147, 188-210 and 235-257 716540010438 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 716540010439 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 716540010440 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540010441 ABC-ATPase subunit interface; other site 716540010442 putative PBP binding loops; other site 716540010443 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 2.6e-50 716540010444 6 transmembrane helices predicted for EAM_2099 by TMHMM2.0 at aa 7-29, 105-127, 147-169, 174-196, 235-257 and 281-303 716540010445 Signal peptide predicted for EAM_2099 by SignalP 2.0 HMM (Signal peptide probability 0.701) with cleavage site probability 0.306 between residues 38 and 39 716540010446 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 716540010447 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 716540010448 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 2.4e-66 716540010449 Signal peptide predicted for EAM_2100 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.990 between residues 23 and 24 716540010450 Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen; Region: GT8_Glycogenin; cd02537 716540010451 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 716540010452 substrate binding site; other site 716540010453 Manganese binding site; other site 716540010454 dimer interface; other site 716540010455 HMMPfam hit to PF01501, Glycosyl transferase family, score 1.5e-15 716540010456 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 716540010457 Signal peptide predicted for EAM_2105 by SignalP 2.0 HMM (Signal peptide probability 0.620) with cleavage site probability 0.616 between residues 39 and 40 716540010458 HMMPfam hit to PF00295, Glycosyl hydrolases family, score 6.1e-84 716540010459 PS00502 Polygalacturonase active site. 716540010460 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 716540010461 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 2.2e-96 716540010462 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 716540010463 6 transmembrane helices predicted for EAM_2110 by TMHMM2.0 at aa 38-60, 73-95, 105-127, 148-170, 180-202 and 215-233 716540010464 HMMPfam hit to PF01810, LysE type translocator, score 4.3e-09 716540010465 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 716540010466 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716540010467 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 716540010468 dimerization interface [polypeptide binding]; other site 716540010469 HMMPfam hit to PF03466, LysR substrate binding domain, score 6.1e-45 716540010470 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 4.7e-16 716540010471 PS00044 Bacterial regulatory proteins, lysR family signature. 716540010472 Predicted helix-turn-helix motif with score 1694.000, SD 4.96 at aa 17-38, sequence FNLTEVANTLFTSQSGVSRHIR 716540010473 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 716540010474 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716540010475 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 716540010476 putative dimerization interface [polypeptide binding]; other site 716540010477 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.3e-30 716540010478 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 9.1e-22 716540010479 PS00044 Bacterial regulatory proteins, lysR family signature. 716540010480 Predicted helix-turn-helix motif with score 1549.000, SD 4.46 at aa 16-37, sequence GSLTQAAEVLHIAQPALSQQVA 716540010481 AAA domain; Region: AAA_21; pfam13304 716540010482 PS00017 ATP/GTP-binding site motif A (P-loop). 716540010483 V-type ATP synthase subunit E; Provisional; Region: PRK02292 716540010484 Signal peptide predicted for EAM_2115 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.732 between residues 23 and 24 716540010485 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540010486 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 716540010487 2 transmembrane helices predicted for EAM_2116 by TMHMM2.0 at aa 5-27 and 34-56 716540010488 Predicted membrane protein [Function unknown]; Region: COG2323 716540010489 3 transmembrane helices predicted for EAM_2117 by TMHMM2.0 at aa 4-26, 38-57 and 62-79 716540010490 HMMPfam hit to PF04239, Protein of unknown function (DUF421), score 2.1e-14 716540010491 AMP nucleosidase; Provisional; Region: PRK08292 716540010492 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 716540010493 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 716540010494 HMMPfam hit to PF01048, Phosphorylase family, score 1.8e-84 716540010495 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 716540010496 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 716540010497 putative NAD(P) binding site [chemical binding]; other site 716540010498 catalytic Zn binding site [ion binding]; other site 716540010499 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like domain, score 5.3e-44 716540010500 PS00059 Zinc-containing alcohol dehydrogenases signature. 716540010501 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 5.4e-38 716540010502 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 716540010503 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716540010504 Walker A motif; other site 716540010505 ATP binding site [chemical binding]; other site 716540010506 Walker B motif; other site 716540010507 arginine finger; other site 716540010508 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 716540010509 DNA-binding interface [nucleotide binding]; DNA binding site 716540010510 HMMPfam hit to PF02954, Bacterial regulatory protein, Fis fam, score 1.2e-09 716540010511 Predicted helix-turn-helix motif with score 1833.000, SD 5.43 at aa 612-633, sequence WNHSAAARQMGISRMTLYRRMQ 716540010512 PS00688 Sigma-54 interaction domain C-terminal part signature. 716540010513 HMMPfam hit to PF00158, Sigma-54 interaction domain, score 1.5e-108 716540010514 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 716540010515 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 716540010516 HMMPfam hit to PF01590, GAF domain, score 1.8e-16 716540010517 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 716540010518 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 716540010519 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 716540010520 dimerization interface [polypeptide binding]; other site 716540010521 putative DNA binding site [nucleotide binding]; other site 716540010522 putative Zn2+ binding site [ion binding]; other site 716540010523 AsnC family; Region: AsnC_trans_reg; pfam01037 716540010524 HMMPfam hit to PF01037, AsnC family, score 5.4e-26 716540010525 Predicted helix-turn-helix motif with score 1483.000, SD 4.24 at aa 20-41, sequence VTNQELAEKIGMSASPCWRKVR 716540010526 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 716540010527 HMMPfam hit to PF07876, Stress responsive A/B Barrel Domain, score 4.8e-15 716540010528 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 716540010529 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 716540010530 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 716540010531 acyl-activating enzyme (AAE) consensus motif; other site 716540010532 AMP binding site [chemical binding]; other site 716540010533 active site 716540010534 CoA binding site [chemical binding]; other site 716540010535 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 716540010536 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 716540010537 homodimer interface [polypeptide binding]; other site 716540010538 substrate-cofactor binding pocket; other site 716540010539 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716540010540 catalytic residue [active] 716540010541 HMMPfam hit to PF01063, Aminotransferase class IV, score 6.3e-61 716540010542 PS00770 Aminotransferases class-IV signature. 716540010543 PBP superfamily domain; Region: PBP_like; cl17867 716540010544 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 716540010545 Uncharacterized conserved protein [Function unknown]; Region: COG2128 716540010546 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 716540010547 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 716540010548 HMMPfam hit to PF02423, Ornithine cyclodeaminase/mu-crystalli, score 2.1e-40 716540010549 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 716540010550 Signal peptide predicted for EAM_2130 by SignalP 2.0 HMM (Signal peptide probability 0.946) with cleavage site probability 0.616 between residues 26 and 27 716540010551 6 transmembrane helices predicted for EAM_2130 by TMHMM2.0 at aa 4-26, 33-55, 70-92, 112-134, 149-171 and 188-205 716540010552 HMMPfam hit to PF01810, LysE type translocator, score 3.4e-09 716540010553 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 716540010554 Signal peptide predicted for EAM_2131 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.813 between residues 27 and 28 716540010555 HMMPfam hit to PF00561, alpha/beta hydrolase fold, score 5.6e-14 716540010556 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 716540010557 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 716540010558 active site 716540010559 FMN binding site [chemical binding]; other site 716540010560 substrate binding site [chemical binding]; other site 716540010561 homotetramer interface [polypeptide binding]; other site 716540010562 catalytic residue [active] 716540010563 HMMPfam hit to PF00724, NADH:flavin oxidoreductase / NADH oxidas, score 1.6e-67 716540010564 MATE family multidrug exporter; Provisional; Region: PRK10189 716540010565 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 716540010566 11 transmembrane helices predicted for EAM_2133 by TMHMM2.0 at aa 45-67, 82-104, 124-146, 161-183, 190-212, 227-249, 269-291, 306-328, 349-371, 386-408 and 430-452 716540010567 HMMPfam hit to PF01554, MatE, score 3.4e-40 716540010568 HMMPfam hit to PF01554, MatE, score 8.1e-39 716540010569 hypothetical protein; Provisional; Region: PRK05423 716540010570 HMMPfam hit to PF04363, Protein of unknown function (DUF496), score 1.3e-62 716540010571 Predicted membrane protein [Function unknown]; Region: COG1289 716540010572 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 716540010573 6 transmembrane helices predicted for EAM_2135 by TMHMM2.0 at aa 21-43, 63-82, 94-116, 136-158, 163-181 and 185-207 716540010574 Signal peptide predicted for EAM_2135 by SignalP 2.0 HMM (Signal peptide probability 0.704) with cleavage site probability 0.606 between residues 42 and 43 716540010575 exonuclease I; Provisional; Region: sbcB; PRK11779 716540010576 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 716540010577 active site 716540010578 catalytic site [active] 716540010579 substrate binding site [chemical binding]; other site 716540010580 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 716540010581 HMMPfam hit to PF00929, Exonuclease, score 6e-30 716540010582 HMMPfam hit to PF08411, Exonuclease C-terminal, score 6.3e-171 716540010583 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 716540010584 HMMPfam hit to PF00324, Amino acid permease, score 5.7e-18 716540010585 12 transmembrane helices predicted for EAM_2137 by TMHMM2.0 at aa 20-38, 53-75, 96-118, 123-145, 158-180, 200-219, 240-262, 289-311, 339-358, 363-385, 398-417 and 422-439 716540010586 Signal peptide predicted for EAM_2137 by SignalP 2.0 HMM (Signal peptide probability 0.806) with cleavage site probability 0.568 between residues 33 and 34 716540010587 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 716540010588 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 716540010589 putative NAD(P) binding site [chemical binding]; other site 716540010590 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase family, score 7.5e-06 716540010591 PS00017 ATP/GTP-binding site motif A (P-loop). 716540010592 1 transmembrane helix predicted for EAM_2140 by TMHMM2.0 at aa 7-29 716540010593 Signal peptide predicted for EAM_2140 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.721 between residues 22 and 23 716540010594 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 716540010595 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 716540010596 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 716540010597 HMMPfam hit to PF01634, ATP phosphoribosyltransferase, score 9.7e-76 716540010598 PS01316 ATP phosphoribosyltransferase signature. 716540010599 HMMPfam hit to PF08029, HisG, C-terminal domain, score 1.2e-37 716540010600 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 716540010601 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 716540010602 NAD binding site [chemical binding]; other site 716540010603 dimerization interface [polypeptide binding]; other site 716540010604 product binding site; other site 716540010605 substrate binding site [chemical binding]; other site 716540010606 zinc binding site [ion binding]; other site 716540010607 catalytic residues [active] 716540010608 HMMPfam hit to PF00815, Histidinol dehydrogenase, score 1.9e-250 716540010609 PS00611 Histidinol dehydrogenase signature. 716540010610 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 716540010611 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 716540010612 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716540010613 homodimer interface [polypeptide binding]; other site 716540010614 catalytic residue [active] 716540010615 HMMPfam hit to PF00155, Aminotransferase class I and II, score 1.5e-77 716540010616 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 716540010617 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 716540010618 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716540010619 active site 716540010620 motif I; other site 716540010621 motif II; other site 716540010622 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 716540010623 putative active site pocket [active] 716540010624 4-fold oligomerization interface [polypeptide binding]; other site 716540010625 metal binding residues [ion binding]; metal-binding site 716540010626 3-fold/trimer interface [polypeptide binding]; other site 716540010627 HMMPfam hit to PF00475, Imidazoleglycerol-phosphate dehydratase, score 1.4e-102 716540010628 PS00954 Imidazoleglycerol-phosphate dehydratase signature 1. 716540010629 PS00955 Imidazoleglycerol-phosphate dehydratase signature 2. 716540010630 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 716540010631 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 716540010632 putative active site [active] 716540010633 oxyanion strand; other site 716540010634 catalytic triad [active] 716540010635 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 4.1e-41 716540010636 HMMPfam hit to PF01174, SNO glutamine amidotransferase family, score 0.014 716540010637 PS00442 Glutamine amidotransferases class-I active site. 716540010638 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 716540010639 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 716540010640 catalytic residues [active] 716540010641 HMMPfam hit to PF00977, Histidine biosynthesis protein, score 2.1e-104 716540010642 HMMPfam hit to PF01791, DeoC/LacD family aldolase, score 0.00057 716540010643 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 716540010644 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 716540010645 substrate binding site [chemical binding]; other site 716540010646 glutamase interaction surface [polypeptide binding]; other site 716540010647 HMMPfam hit to PF00977, Histidine biosynthesis protein, score 4.2e-118 716540010648 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 716540010649 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 716540010650 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 716540010651 metal binding site [ion binding]; metal-binding site 716540010652 HMMPfam hit to PF01502, Phosphoribosyl-AMP cyclohydrolase, score 3.7e-38 716540010653 HMMPfam hit to PF01503, Phosphoribosyl-ATP pyrophosphohydrolase, score 1.6e-46 716540010654 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 716540010655 putative deacylase active site [active] 716540010656 HMMPfam hit to PF04073, YbaK / prolyl-tRNA synthetases associated do, score 1.1e-42 716540010657 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 716540010658 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 716540010659 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 716540010660 HMMPfam hit to PF00393, 6-phosphogluconate dehydrogenase, C-ter, score 3.6e-222 716540010661 PS00461 6-phosphogluconate dehydrogenase signature. 716540010662 HMMPfam hit to PF03446, NAD binding domain of 6-phosphogluconat, score 7.9e-85 716540010663 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 716540010664 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 716540010665 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 716540010666 putative ADP-binding pocket [chemical binding]; other site 716540010667 HMMPfam hit to PF00534, Glycosyl transferases group, score 2e-35 716540010668 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 716540010669 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 716540010670 active site 716540010671 HMMPfam hit to PF00535, Glycosyl transferase family, score 6.3e-10 716540010672 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 716540010673 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 716540010674 UDP-galactopyranose mutase; Region: GLF; pfam03275 716540010675 HMMPfam hit to PF03275, UDP-galactopyranose mutase, score 3.3e-120 716540010676 Signal peptide predicted for EAM_2154 by SignalP 2.0 HMM (Signal peptide probability 0.906) with cleavage site probability 0.727 between residues 18 and 19 716540010677 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 716540010678 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 716540010679 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 716540010680 Ligand binding site; other site 716540010681 metal-binding site 716540010682 HMMPfam hit to PF01501, Glycosyl transferase family, score 1.3e-71 716540010683 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 716540010684 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 716540010685 Walker A/P-loop; other site 716540010686 ATP binding site [chemical binding]; other site 716540010687 Q-loop/lid; other site 716540010688 ABC transporter signature motif; other site 716540010689 Walker B; other site 716540010690 D-loop; other site 716540010691 H-loop/switch region; other site 716540010692 HMMPfam hit to PF00005, ABC transporter, score 1.1e-37 716540010693 PS00211 ABC transporters family signature. 716540010694 PS00017 ATP/GTP-binding site motif A (P-loop). 716540010695 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 716540010696 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 716540010697 6 transmembrane helices predicted for EAM_2157 by TMHMM2.0 at aa 27-49, 64-86, 106-128, 143-165, 172-194 and 223-245 716540010698 HMMPfam hit to PF01061, ABC-2 type transporter, score 3.1e-09 716540010699 PS00890 ABC-2 type transport system integral membrane proteins signature. 716540010700 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 716540010701 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 716540010702 NAD(P) binding site [chemical binding]; other site 716540010703 active site 716540010704 HMMPfam hit to PF04321, RmlD substrate binding domain, score 0.0022 716540010705 HMMPfam hit to PF01073, 3-beta hydroxysteroid dehydrogenase/iso, score 4.9e-07 716540010706 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase fam, score 4.1e-28 716540010707 HMMPfam hit to PF07993, Male sterility protein, score 0.00027 716540010708 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 716540010709 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 716540010710 substrate binding site; other site 716540010711 tetramer interface; other site 716540010712 HMMPfam hit to PF00483, Nucleotidyl transferase, score 1.3e-106 716540010713 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 716540010714 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 716540010715 NAD binding site [chemical binding]; other site 716540010716 substrate binding site [chemical binding]; other site 716540010717 homodimer interface [polypeptide binding]; other site 716540010718 active site 716540010719 HMMPfam hit to PF04321, RmlD substrate binding domain, score 1.7e-06 716540010720 HMMPfam hit to PF01073, 3-beta hydroxysteroid dehydrogenase/i, score 9.1e-08 716540010721 HMMPfam hit to PF02719, Polysaccharide biosynthesis protein, score 2.5e-06 716540010722 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase f, score 1.9e-92 716540010723 HMMPfam hit to PF07993, Male sterility protein, score 1.3e-07 716540010724 PS00061 Short-chain dehydrogenases/reductases family signature. 716540010725 UDP-glucose 4-epimerase; Region: PLN02240 716540010726 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 716540010727 NAD binding site [chemical binding]; other site 716540010728 homodimer interface [polypeptide binding]; other site 716540010729 active site 716540010730 substrate binding site [chemical binding]; other site 716540010731 HMMPfam hit to PF04321, RmlD substrate binding domain, score 4.7e-05 716540010732 PS00097 Aspartate and ornithine carbamoyltransferases signature. 716540010733 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase f, score 1.4e-89 716540010734 HMMPfam hit to PF02719, Polysaccharide biosynthesis protein, score 1.2e-05 716540010735 HMMPfam hit to PF01073, 3-beta hydroxysteroid dehydrogenase/i, score 5.4e-10 716540010736 HMMPfam hit to PF07993, Male sterility protein, score 4.5e-05 716540010737 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 716540010738 active site 716540010739 tetramer interface; other site 716540010740 HMMPfam hit to PF00483, Nucleotidyl transferase, score 1.2e-12 716540010741 Signal peptide predicted for EAM_2162 by SignalP 2.0 HMM (Signal peptide probability 0.784) with cleavage site probability 0.729 between residues 22 and 23 716540010742 Amylovoran biosynthesis locus 716540010743 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 716540010744 11 transmembrane helices predicted for EAM_2163 by TMHMM2.0 at aa 7-29, 42-64, 77-99, 104-126, 139-161, 166-188, 283-305, 320-342, 355-377, 387-409 and 416-438 716540010745 HMMPfam hit to PF01943, Polysaccharide biosynthesis protein, score 5.2e-38 716540010746 Signal peptide predicted for EAM_2163 by SignalP 2.0 HMM (Signal peptide probability 0.957) with cleavage site probability 0.260 between residues 22 and 23 716540010747 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 716540010748 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 716540010749 putative ADP-binding pocket [chemical binding]; other site 716540010750 HMMPfam hit to PF00534, Glycosyl transferases group, score 2e-38 716540010751 colanic acid biosynthesis protein; Provisional; Region: PRK10017 716540010752 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 716540010753 HMMPfam hit to PF04230, Polysaccharide pyruvyl transferase, score 1.9e-147 716540010754 Head binding; Region: Head_binding; pfam09008 716540010755 Signal peptide predicted for EAM_2166 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.915 between residues 27 and 28 716540010756 GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; Region: GT2_AmsE_like; cd04195 716540010757 HMMPfam hit to PF00535, Glycosyl transferase family, score 6.4e-32 716540010758 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 716540010759 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 716540010760 putative ADP-binding pocket [chemical binding]; other site 716540010761 HMMPfam hit to PF00534, Glycosyl transferases group, score 9.8e-48 716540010762 11 transmembrane helices predicted for EAM_2169 by TMHMM2.0 at aa 5-22, 32-51, 91-113, 128-145, 152-174, 178-200, 207-224, 252-274, 286-305, 309-331 and 336-358 716540010763 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 716540010764 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 716540010765 active site 716540010766 HMMPfam hit to PF00535, Glycosyl transferase family, score 9.2e-32 716540010767 tyrosine kinase; Provisional; Region: PRK11519 716540010768 Chain length determinant protein; Region: Wzz; pfam02706 716540010769 Chain length determinant protein; Region: Wzz; cl15801 716540010770 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 716540010771 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 716540010772 P loop; other site 716540010773 Nucleotide binding site [chemical binding]; other site 716540010774 DTAP/Switch II; other site 716540010775 Switch I; other site 716540010776 PS00017 ATP/GTP-binding site motif A (P-loop). 716540010777 2 transmembrane helices predicted for EAM_2171 by TMHMM2.0 at aa 32-51 and 425-444 716540010778 HMMPfam hit to PF02706, Chain length determinant protein, score 1.1e-86 716540010779 Low molecular weight phosphatase family; Region: LMWPc; cd00115 716540010780 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 716540010781 active site 716540010782 HMMPfam hit to PF01451, Low molecular weight phosphotyrosine protein, score 1.3e-63 716540010783 polysaccharide export protein Wza; Provisional; Region: PRK15078 716540010784 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 716540010785 SLBB domain; Region: SLBB; pfam10531 716540010786 SLBB domain; Region: SLBB; pfam10531 716540010787 HMMPfam hit to PF02563, Polysaccharide biosynthesis/export protei, score 6.2e-62 716540010788 Signal peptide predicted for EAM_2173 by SignalP 2.0 HMM (Signal peptide probability 0.926) with cleavage site probability 0.582 between residues 36 and 37 716540010789 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540010790 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 716540010791 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 716540010792 Bacterial sugar transferase; Region: Bac_transf; pfam02397 716540010793 HMMPfam hit to PF02397, Bacterial sugar transferase, score 6.7e-163 716540010794 5 transmembrane helices predicted for EAM_2174 by TMHMM2.0 at aa 13-35, 55-77, 90-108, 113-135 and 286-308 716540010795 PS00228 Tubulin-beta mRNA autoregulation signal. 716540010796 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 716540010797 FOG: CBS domain [General function prediction only]; Region: COG0517 716540010798 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 716540010799 Transporter associated domain; Region: CorC_HlyC; smart01091 716540010800 7 transmembrane helices predicted for EAM_2175 by TMHMM2.0 at aa 10-32, 51-73, 83-100, 129-151, 155-172, 179-201 and 206-228 716540010801 HMMPfam hit to PF03741, Integral membrane protein TerC family, score 4.5e-32 716540010802 HMMPfam hit to PF00571, CBS domain pair, score 1.8e-23 716540010803 HMMPfam hit to PF03471, Transporter associated domain, score 4.7e-18 716540010804 putative assembly protein; Provisional; Region: PRK10833 716540010805 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 716540010806 HMMPfam hit to PF05170, AsmA family, score 7.3e-51 716540010807 Signal peptide predicted for EAM_2176 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.774 between residues 26 and 27 716540010808 1 transmembrane helix predicted for EAM_2176 by TMHMM2.0 at aa 7-26 716540010809 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 716540010810 trimer interface [polypeptide binding]; other site 716540010811 active site 716540010812 HMMPfam hit to PF00692, dUTPase, score 2.3e-05 716540010813 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 716540010814 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 716540010815 ATP-binding site [chemical binding]; other site 716540010816 Sugar specificity; other site 716540010817 Pyrimidine base specificity; other site 716540010818 HMMPfam hit to PF00485, Phosphoribulokinase / Uridine kinase family, score 1.2e-45 716540010819 PS00017 ATP/GTP-binding site motif A (P-loop). 716540010820 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 716540010821 active site 716540010822 6 transmembrane helices predicted for EAM_2179 by TMHMM2.0 at aa 10-31, 40-62, 72-94, 99-121, 131-148 and 155-174 716540010823 HMMPfam hit to PF01569, PAP2 superfamily, score 3.3e-06 716540010824 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 716540010825 PAS domain S-box; Region: sensory_box; TIGR00229 716540010826 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 716540010827 putative active site [active] 716540010828 heme pocket [chemical binding]; other site 716540010829 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 716540010830 PAS fold; Region: PAS_3; pfam08447 716540010831 putative active site [active] 716540010832 heme pocket [chemical binding]; other site 716540010833 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 716540010834 PAS domain; Region: PAS_9; pfam13426 716540010835 putative active site [active] 716540010836 heme pocket [chemical binding]; other site 716540010837 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 716540010838 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 716540010839 metal binding site [ion binding]; metal-binding site 716540010840 active site 716540010841 I-site; other site 716540010842 9 transmembrane helices predicted for EAM_2180 by TMHMM2.0 at aa 12-34, 39-58, 65-87, 91-108, 128-147, 157-179, 192-214, 237-254 and 267-289 716540010843 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540010844 HMMPfam hit to PF05231, MASE1, score 3.2e-18 716540010845 HMMPfam hit to PF00989, PAS fold, score 1.9e-09 716540010846 HMMPfam hit to PF08448, PAS fold, score 2.5e-05 716540010847 HMMPfam hit to PF08447, PAS fold, score 3e-14 716540010848 HMMPfam hit to PF08447, PAS fold, score 3e-15 716540010849 HMMPfam hit to PF00989, PAS fold, score 4.4e-05 716540010850 HMMPfam hit to PF08448, PAS fold, score 6e-08 716540010851 HMMPfam hit to PF00990, GGDEF domain, score 4.2e-55 716540010852 putative chaperone; Provisional; Region: PRK11678 716540010853 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 716540010854 nucleotide binding site [chemical binding]; other site 716540010855 putative NEF/HSP70 interaction site [polypeptide binding]; other site 716540010856 SBD interface [polypeptide binding]; other site 716540010857 PS00329 Heat shock hsp70 proteins family signature 2. 716540010858 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 716540010859 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 716540010860 active site 716540010861 catalytic tetrad [active] 716540010862 HMMPfam hit to PF00248, Aldo/keto reductase family, score 2.8e-57 716540010863 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 716540010864 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 716540010865 HlyD family secretion protein; Region: HlyD_3; pfam13437 716540010866 Signal peptide predicted for EAM_2183 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.220 between residues 32 and 33 716540010867 1 transmembrane helix predicted for EAM_2183 by TMHMM2.0 at aa 7-29 716540010868 HMMPfam hit to PF00529, HlyD family secretion protein, score 5.8e-25 716540010869 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 716540010870 Protein export membrane protein; Region: SecD_SecF; cl14618 716540010871 HMMPfam hit to PF00873, AcrB/AcrD/AcrF family, score 0 716540010872 10 transmembrane helices predicted for EAM_2184 by TMHMM2.0 at aa 16-38, 343-362, 369-391, 438-460, 472-494, 535-557, 867-889, 909-931, 962-984 and 999-1021 716540010873 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 716540010874 Signal peptide predicted for EAM_2185 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.509 between residues 36 and 37 716540010875 HMMPfam hit to PF00873, AcrB/AcrD/AcrF family, score 0 716540010876 10 transmembrane helices predicted for EAM_2185 by TMHMM2.0 at aa 7-29, 336-353, 360-382, 434-456, 463-485, 526-545, 853-875, 895-917, 948-970 and 985-1007 716540010877 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 716540010878 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 716540010879 dimerization interface [polypeptide binding]; other site 716540010880 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 716540010881 dimer interface [polypeptide binding]; other site 716540010882 phosphorylation site [posttranslational modification] 716540010883 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716540010884 ATP binding site [chemical binding]; other site 716540010885 Mg2+ binding site [ion binding]; other site 716540010886 G-X-G motif; other site 716540010887 1 transmembrane helix predicted for EAM_2186 by TMHMM2.0 at aa 13-32 716540010888 HMMPfam hit to PF00672, HAMP domain, score 1.5e-19 716540010889 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 3.2e-14 716540010890 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 4.4e-36 716540010891 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 716540010892 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716540010893 active site 716540010894 phosphorylation site [posttranslational modification] 716540010895 intermolecular recognition site; other site 716540010896 dimerization interface [polypeptide binding]; other site 716540010897 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 716540010898 DNA binding site [nucleotide binding] 716540010899 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.2e-31 716540010900 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 1.2e-23 716540010901 PS00294 Prenyl group binding site (CAAX box). 716540010902 HMMPfam hit to PF01136, Peptidase family U32, score 7.9e-07 716540010903 Tir chaperone protein (CesT) family; Region: CesT; cl08444 716540010904 lipid kinase; Reviewed; Region: PRK13054 716540010905 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 716540010906 HMMPfam hit to PF00781, Diacylglycerol kinase catalytic domain (pres, score 1.2e-32 716540010907 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 716540010908 dimer interface [polypeptide binding]; other site 716540010909 substrate binding site [chemical binding]; other site 716540010910 ATP binding site [chemical binding]; other site 716540010911 HMMPfam hit to PF08543, Phosphomethylpyrimidine kinase, score 6e-135 716540010912 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 716540010913 substrate binding site [chemical binding]; other site 716540010914 multimerization interface [polypeptide binding]; other site 716540010915 ATP binding site [chemical binding]; other site 716540010916 HMMPfam hit to PF02110, Hydroxyethylthiazole kinase family, score 3.7e-118 716540010917 chorismate mutase; Provisional; Region: PRK08055 716540010918 HMMPfam hit to PF01817, Chorismate mutase type II, score 0.00037 716540010919 1 transmembrane helix predicted for EAM_2195 by TMHMM2.0 at aa 7-26 716540010920 Signal peptide predicted for EAM_2195 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.872 between residues 23 and 24 716540010921 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 716540010922 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716540010923 Coenzyme A binding pocket [chemical binding]; other site 716540010924 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 5.1e-14 716540010925 antiporter inner membrane protein; Provisional; Region: PRK11670 716540010926 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 716540010927 PS01215 Mrp family signature. 716540010928 PS00017 ATP/GTP-binding site motif A (P-loop). 716540010929 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 716540010930 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 716540010931 active site 716540010932 HIGH motif; other site 716540010933 KMSKS motif; other site 716540010934 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 716540010935 tRNA binding surface [nucleotide binding]; other site 716540010936 anticodon binding site; other site 716540010937 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 716540010938 dimer interface [polypeptide binding]; other site 716540010939 putative tRNA-binding site [nucleotide binding]; other site 716540010940 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 716540010941 HMMPfam hit to PF01588, tRNA binding domain, score 1e-36 716540010942 hypothetical protein; Provisional; Region: PRK01821 716540010943 4 transmembrane helices predicted for EAM_2200 by TMHMM2.0 at aa 7-29, 39-61, 66-83 and 93-115 716540010944 HMMPfam hit to PF03788, LrgA family, score 5.1e-46 716540010945 hypothetical protein; Provisional; Region: PRK10711 716540010946 Signal peptide predicted for EAM_2201 by SignalP 2.0 HMM (Signal peptide probability 0.727) with cleavage site probability 0.614 between residues 22 and 23 716540010947 6 transmembrane helices predicted for EAM_2201 by TMHMM2.0 at aa 4-22, 27-49, 59-77, 90-112, 142-164 and 200-222 716540010948 HMMPfam hit to PF04172, LrgB-like family, score 2e-108 716540010949 cytidine deaminase; Provisional; Region: PRK09027 716540010950 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 716540010951 active site 716540010952 catalytic motif [active] 716540010953 Zn binding site [ion binding]; other site 716540010954 Cytidine and deoxycytidylate deaminase zinc-binding region; Region: dCMP_cyt_deam_2; pfam08211 716540010955 HMMPfam hit to PF00383, Cytidine and deoxycytidylate deaminas, score 1.1e-15 716540010956 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 716540010957 HMMPfam hit to PF08211, Cytidine and deoxycytidylate deaminas, score 3.2e-62 716540010958 malate dehydrogenase; Provisional; Region: PRK13529 716540010959 Malic enzyme, N-terminal domain; Region: malic; pfam00390 716540010960 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 716540010961 NAD(P) binding site [chemical binding]; other site 716540010962 HMMPfam hit to PF00390, Malic enzyme, N-terminal domain, score 2.1e-125 716540010963 PS00331 Malic enzymes signature. 716540010964 HMMPfam hit to PF03949, Malic enzyme, NAD binding domain, score 1.2e-135 716540010965 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 716540010966 putative active site [active] 716540010967 Signal peptide predicted for EAM_2204 by SignalP 2.0 HMM (Signal peptide probability 0.966) with cleavage site probability 0.829 between residues 22 and 23 716540010968 1 transmembrane helix predicted for EAM_2204 by TMHMM2.0 at aa 5-27 716540010969 HMMPfam hit to PF02698, DUF218 domain, score 1.5e-40 716540010970 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 716540010971 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 716540010972 TM-ABC transporter signature motif; other site 716540010973 8 transmembrane helices predicted for EAM_2205 by TMHMM2.0 at aa 9-31, 105-127, 134-153, 183-202, 223-245, 260-282, 284-306 and 311-333 716540010974 HMMPfam hit to PF02653, Branched-chain amino acid transport syst, score 2.4e-63 716540010975 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 716540010976 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 716540010977 Walker A/P-loop; other site 716540010978 ATP binding site [chemical binding]; other site 716540010979 Q-loop/lid; other site 716540010980 ABC transporter signature motif; other site 716540010981 Walker B; other site 716540010982 D-loop; other site 716540010983 H-loop/switch region; other site 716540010984 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 716540010985 HMMPfam hit to PF00005, ABC transporter, score 2.3e-14 716540010986 PS00211 ABC transporters family signature. 716540010987 HMMPfam hit to PF00005, ABC transporter, score 5.2e-35 716540010988 PS00017 ATP/GTP-binding site motif A (P-loop). 716540010989 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 716540010990 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 716540010991 ligand binding site [chemical binding]; other site 716540010992 calcium binding site [ion binding]; other site 716540010993 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 0.00061 716540010994 1 transmembrane helix predicted for EAM_2207 by TMHMM2.0 at aa 5-24 716540010995 Signal peptide predicted for EAM_2207 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.965 between residues 23 and 24 716540010996 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 716540010997 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 716540010998 DNA binding site [nucleotide binding] 716540010999 domain linker motif; other site 716540011000 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 716540011001 dimerization interface (closed form) [polypeptide binding]; other site 716540011002 ligand binding site [chemical binding]; other site 716540011003 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 2.9e-07 716540011004 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 8.5e-12 716540011005 Predicted helix-turn-helix motif with score 2333.000, SD 7.13 at aa 2-23, sequence LTIRDVAREAGVSVATVSRVLN 716540011006 PS00356 Bacterial regulatory proteins, lacI family signature. 716540011007 Predicted membrane protein [Function unknown]; Region: COG2311 716540011008 hypothetical protein; Provisional; Region: PRK10835 716540011009 HMMPfam hit to PF04235, Protein of unknown function (DUF418), score 3.4e-52 716540011010 8 transmembrane helices predicted for EAM_2209 by TMHMM2.0 at aa 13-35, 55-77, 89-111, 131-153, 235-257, 272-289, 309-327 and 337-359 716540011011 HMMPfam hit to PF04171, Protein of unknown function (DUF405), score 2.9e-52 716540011012 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 716540011013 homodecamer interface [polypeptide binding]; other site 716540011014 GTP cyclohydrolase I; Provisional; Region: PLN03044 716540011015 active site 716540011016 putative catalytic site residues [active] 716540011017 zinc binding site [ion binding]; other site 716540011018 GTP-CH-I/GFRP interaction surface; other site 716540011019 HMMPfam hit to PF01227, GTP cyclohydrolase I, score 1.8e-52 716540011020 PS00860 GTP cyclohydrolase I signature 2. 716540011021 PS00859 GTP cyclohydrolase I signature 1. 716540011022 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716540011023 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716540011024 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 716540011025 putative dimerization interface [polypeptide binding]; other site 716540011026 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 7.8e-17 716540011027 PS00044 Bacterial regulatory proteins, lysR family signature. 716540011028 HMMPfam hit to PF03466, LysR substrate binding domain, score 3.6e-42 716540011029 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 716540011030 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 716540011031 substrate binding site [chemical binding]; other site 716540011032 catalytic Zn binding site [ion binding]; other site 716540011033 NAD binding site [chemical binding]; other site 716540011034 structural Zn binding site [ion binding]; other site 716540011035 dimer interface [polypeptide binding]; other site 716540011036 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like domain, score 8.9e-38 716540011037 PS00059 Zinc-containing alcohol dehydrogenases signature. 716540011038 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 5.1e-35 716540011039 S-formylglutathione hydrolase; Region: PLN02442 716540011040 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 716540011041 HMMPfam hit to PF00756, esterase, score 3.6e-94 716540011042 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 716540011043 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 716540011044 putative active site [active] 716540011045 putative catalytic triad [active] 716540011046 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 716540011047 aromatic chitin/cellulose binding site residues [chemical binding]; other site 716540011048 HMMPfam hit to PF02839, Carbohydrate binding domain, score 0.024 716540011049 HMMPfam hit to PF00082, Subtilase family, score 1.9e-06 716540011050 PS00138 Serine proteases, subtilase family, serine active site. 716540011051 Signal peptide predicted for EAM_2214 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.698 between residues 30 and 31 716540011052 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 716540011053 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 716540011054 Walker A/P-loop; other site 716540011055 ATP binding site [chemical binding]; other site 716540011056 Q-loop/lid; other site 716540011057 ABC transporter signature motif; other site 716540011058 Walker B; other site 716540011059 D-loop; other site 716540011060 H-loop/switch region; other site 716540011061 HMMPfam hit to PF00005, ABC transporter, score 3.5e-50 716540011062 HMMPfam hit to PF02463, RecF/RecN/SMC N terminal domain, score 9.8e-05 716540011063 PS00211 ABC transporters family signature. 716540011064 PS00017 ATP/GTP-binding site motif A (P-loop). 716540011065 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 716540011066 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 716540011067 dimer interface [polypeptide binding]; other site 716540011068 putative PBP binding regions; other site 716540011069 ABC-ATPase subunit interface; other site 716540011070 HMMPfam hit to PF01032, FecCD transport family, score 1e-83 716540011071 9 transmembrane helices predicted for EAM_2216 by TMHMM2.0 at aa 30-52, 77-99, 119-141, 145-162, 175-197, 217-239, 269-291, 306-325 and 332-354 716540011072 lysine transporter; Provisional; Region: PRK10836 716540011073 HMMPfam hit to PF00324, Amino acid permease, score 1.8e-188 716540011074 12 transmembrane helices predicted for EAM_2217 by TMHMM2.0 at aa 21-43, 53-75, 103-125, 130-152, 159-181, 196-218, 245-267, 287-309, 343-365, 370-392, 413-435 and 445-467 716540011075 PS00218 Amino acid permeases signature. 716540011076 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 716540011077 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716540011078 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 716540011079 putative dimerization interface [polypeptide binding]; other site 716540011080 HMMPfam hit to PF03466, LysR substrate binding domain, score 3.9e-54 716540011081 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.5e-18 716540011082 PS00044 Bacterial regulatory proteins, lysR family signature. 716540011083 Predicted helix-turn-helix motif with score 1221.000, SD 3.35 at aa 23-44, sequence GSTTQASQVLALSQSAVSAALA 716540011084 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 716540011085 Signal peptide predicted for EAM_2219 by SignalP 2.0 HMM (Signal peptide probability 0.855) with cleavage site probability 0.475 between residues 40 and 41 716540011086 10 transmembrane helices predicted for EAM_2219 by TMHMM2.0 at aa 12-34, 39-61, 100-119, 134-156, 163-185, 200-222, 229-248, 263-282, 295-313 and 323-345 716540011087 HMMPfam hit to PF03601, Conserved hypothetical protein, score 5.6e-133 716540011088 endonuclease IV; Provisional; Region: PRK01060 716540011089 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 716540011090 AP (apurinic/apyrimidinic) site pocket; other site 716540011091 DNA interaction; other site 716540011092 Metal-binding active site; metal-binding site 716540011093 HMMPfam hit to PF01261, Xylose isomerase-like TIM barrel, score 9.5e-64 716540011094 PS00729 AP endonucleases family 2 signature 1. 716540011095 PS00730 AP endonucleases family 2 signature 2. 716540011096 PS00017 ATP/GTP-binding site motif A (P-loop). 716540011097 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 716540011098 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 716540011099 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 716540011100 active site 716540011101 P-loop; other site 716540011102 phosphorylation site [posttranslational modification] 716540011103 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 716540011104 9 transmembrane helices predicted for EAM_2221 by TMHMM2.0 at aa 239-261, 274-296, 306-328, 348-370, 380-402, 415-437, 467-484, 491-513 and 528-550 716540011105 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 7.7e-17 716540011106 HMMPfam hit to PF02379, PTS system, Fructose specific IIB subuni, score 9.5e-58 716540011107 Signal peptide predicted for EAM_2221 by SignalP 2.0 HMM (Signal peptide probability 0.791) with cleavage site probability 0.249 between residues 27 and 28 716540011108 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 716540011109 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 716540011110 putative substrate binding site [chemical binding]; other site 716540011111 putative ATP binding site [chemical binding]; other site 716540011112 HMMPfam hit to PF00294, pfkB family carbohydrate kinase, score 2.6e-68 716540011113 PS00584 pfkB family of carbohydrate kinases signature 2. 716540011114 PS00583 pfkB family of carbohydrate kinases signature 1. 716540011115 PS00464 Ribosomal protein L22 signature. 716540011116 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 716540011117 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 716540011118 active site 716540011119 phosphorylation site [posttranslational modification] 716540011120 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 716540011121 dimerization domain swap beta strand [polypeptide binding]; other site 716540011122 regulatory protein interface [polypeptide binding]; other site 716540011123 active site 716540011124 regulatory phosphorylation site [posttranslational modification]; other site 716540011125 HMMPfam hit to PF00381, PTS HPr component phosphorylation site, score 1.7e-42 716540011126 PS00589 PTS HPR component serine phosphorylation site signature. 716540011127 PS00369 PTS HPR component histidine phosphorylation site signature. 716540011128 HMMPfam hit to PF00359, Phosphoenolpyruvate-dependent sugar phosph, score 3.2e-68 716540011129 PS00372 PTS EIIA domains phosphorylation site signature 2. 716540011130 Flagellin N-methylase; Region: FliB; cl00497 716540011131 HMMPfam hit to PF03692, Uncharacterised protein family (UPF0153), score 2.7e-12 716540011132 elongation factor P; Provisional; Region: PRK04542 716540011133 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 716540011134 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 716540011135 RNA binding site [nucleotide binding]; other site 716540011136 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 716540011137 RNA binding site [nucleotide binding]; other site 716540011138 HMMPfam hit to PF08207, Elongation factor P (EF-P) KOW-like domain, score 1.4e-20 716540011139 HMMPfam hit to PF01132, Elongation factor P (EF-P) OB domain, score 3.3e-24 716540011140 PS01275 Elongation factor P signature. 716540011141 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 716540011142 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 716540011143 active site 716540011144 Signal peptide predicted for EAM_2226 by SignalP 2.0 HMM (Signal peptide probability 0.685) with cleavage site probability 0.427 between residues 30 and 31 716540011145 5 transmembrane helices predicted for EAM_2226 by TMHMM2.0 at aa 7-25, 62-81, 93-115, 160-182 and 189-211 716540011146 HMMPfam hit to PF01569, PAP2 superfamily, score 3.9e-06 716540011147 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 716540011148 NlpC/P60 family; Region: NLPC_P60; pfam00877 716540011149 Signal peptide predicted for EAM_2227 by SignalP 2.0 HMM (Signal peptide probability 0.991) with cleavage site probability 0.620 between residues 34 and 35 716540011150 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540011151 HMMPfam hit to PF00877, NlpC/P60 family, score 3.3e-46 716540011152 phage resistance protein; Provisional; Region: PRK10551 716540011153 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 716540011154 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 716540011155 Signal peptide predicted for EAM_2228 by SignalP 2.0 HMM (Signal peptide probability 0.820) with cleavage site probability 0.564 between residues 40 and 41 716540011156 2 transmembrane helices predicted for EAM_2228 by TMHMM2.0 at aa 20-42 and 243-265 716540011157 HMMPfam hit to PF00563, EAL domain, score 3e-87 716540011158 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 716540011159 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 716540011160 Signal peptide predicted for EAM_2229 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 20 and 21 716540011161 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 2.3e-60 716540011162 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 716540011163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540011164 dimer interface [polypeptide binding]; other site 716540011165 conserved gate region; other site 716540011166 putative PBP binding loops; other site 716540011167 ABC-ATPase subunit interface; other site 716540011168 6 transmembrane helices predicted for EAM_2230 by TMHMM2.0 at aa 9-31, 132-151, 172-194, 223-245, 284-306 and 326-345 716540011169 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 5.3e-52 716540011170 microcin C ABC transporter permease; Provisional; Region: PRK15021 716540011171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540011172 dimer interface [polypeptide binding]; other site 716540011173 conserved gate region; other site 716540011174 ABC-ATPase subunit interface; other site 716540011175 Signal peptide predicted for EAM_2231 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.937 between residues 42 and 43 716540011176 6 transmembrane helices predicted for EAM_2231 by TMHMM2.0 at aa 21-43, 146-168, 180-199, 203-222, 257-279 and 306-328 716540011177 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.2e-46 716540011178 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 716540011179 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 716540011180 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 716540011181 Walker A/P-loop; other site 716540011182 ATP binding site [chemical binding]; other site 716540011183 Q-loop/lid; other site 716540011184 ABC transporter signature motif; other site 716540011185 Walker B; other site 716540011186 D-loop; other site 716540011187 H-loop/switch region; other site 716540011188 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 716540011189 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 716540011190 Walker A/P-loop; other site 716540011191 ATP binding site [chemical binding]; other site 716540011192 Q-loop/lid; other site 716540011193 ABC transporter signature motif; other site 716540011194 Walker B; other site 716540011195 D-loop; other site 716540011196 H-loop/switch region; other site 716540011197 HMMPfam hit to PF00005, ABC transporter, score 1e-59 716540011198 PS00017 ATP/GTP-binding site motif A (P-loop). 716540011199 PS00211 ABC transporters family signature. 716540011200 HMMPfam hit to PF00005, ABC transporter, score 6.5e-60 716540011201 PS00017 ATP/GTP-binding site motif A (P-loop). 716540011202 PS00211 ABC transporters family signature. 716540011203 hypothetical protein; Provisional; Region: PRK11835 716540011204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540011205 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 716540011206 putative substrate translocation pore; other site 716540011207 12 transmembrane helices predicted for EAM_2234 by TMHMM2.0 at aa 7-29, 47-69, 76-98, 102-124, 137-159, 163-185, 219-241, 251-273, 280-302, 307-329, 342-364 and 369-391 716540011208 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.7e-50 716540011209 Signal peptide predicted for EAM_2234 by SignalP 2.0 HMM (Signal peptide probability 0.739) with cleavage site probability 0.468 between residues 37 and 38 716540011210 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 716540011211 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 716540011212 RNA binding surface [nucleotide binding]; other site 716540011213 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 716540011214 active site 716540011215 uracil binding [chemical binding]; other site 716540011216 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 3.3e-25 716540011217 PS01149 Rsu family of pseudouridine synthase signature. 716540011218 HMMPfam hit to PF01479, S4 domain, score 1e-09 716540011219 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 716540011220 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 716540011221 ATP binding site [chemical binding]; other site 716540011222 putative Mg++ binding site [ion binding]; other site 716540011223 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 716540011224 nucleotide binding region [chemical binding]; other site 716540011225 ATP-binding site [chemical binding]; other site 716540011226 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 716540011227 HMMPfam hit to PF04851, Type III restriction enzyme, res subunit, score 1.2e-35 716540011228 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 1.9e-11 716540011229 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 2.1e-08 716540011230 PS00017 ATP/GTP-binding site motif A (P-loop). 716540011231 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 716540011232 5S rRNA interface [nucleotide binding]; other site 716540011233 CTC domain interface [polypeptide binding]; other site 716540011234 L16 interface [polypeptide binding]; other site 716540011235 HMMPfam hit to PF01386, Ribosomal L25p family, score 3.2e-43 716540011236 Nucleoid-associated protein [General function prediction only]; Region: COG3081 716540011237 nucleoid-associated protein NdpA; Validated; Region: PRK00378 716540011238 HMMPfam hit to PF04245, 37-kD nucleoid-associated bacterial protein, score 4.1e-172 716540011239 hypothetical protein; Provisional; Region: PRK13689 716540011240 HMMPfam hit to PF07208, Protein of unknown function (DUF1414), score 6.4e-44 716540011241 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 716540011242 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 716540011243 Sulfatase; Region: Sulfatase; cl17466 716540011244 PS00430 TonB-dependent receptor proteins signature 1. 716540011245 5 transmembrane helices predicted for EAM_2240 by TMHMM2.0 at aa 21-43, 58-80, 85-107, 135-157 and 168-190 716540011246 HMMPfam hit to PF00884, Sulfatase, score 1.9e-33 716540011247 HMMPfam hit to PF00589, Phage integrase family, score 6.2e-10 716540011248 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 716540011249 Part of AAA domain; Region: AAA_19; pfam13245 716540011250 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 716540011251 AAA domain; Region: AAA_12; pfam13087 716540011252 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 716540011253 putative active site [active] 716540011254 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 716540011255 PS00018 EF-hand calcium-binding domain. 716540011256 PS00017 ATP/GTP-binding site motif A (P-loop). 716540011257 Restriction endonuclease; Region: Mrr_cat; pfam04471 716540011258 HMMPfam hit to PF04471, Restriction endonuclease, score 1.2e-28 716540011259 4 transmembrane helices predicted for EAM_2245 by TMHMM2.0 at aa 36-58, 68-90, 149-171 and 189-211 716540011260 Acyltransferase family; Region: Acyl_transf_3; pfam01757 716540011261 HMMPfam hit to PF01757, Acyltransferase family, score 1.4e-06 716540011262 8 transmembrane helices predicted for EAM_2247 by TMHMM2.0 at aa 7-24, 39-61, 87-104, 140-162, 167-186, 190-207, 228-245 and 255-277 716540011263 HTH-like domain; Region: HTH_21; pfam13276 716540011264 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 716540011265 Integrase core domain; Region: rve; pfam00665 716540011266 3 transmembrane helices predicted for EAM_2252 by TMHMM2.0 at aa 7-29, 49-71 and 109-131 716540011267 1 transmembrane helix predicted for EAM_2253 by TMHMM2.0 at aa 15-37 716540011268 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540011269 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 716540011270 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 716540011271 HMMPfam hit to PF01648, 4'-phosphopantetheinyl transferase superfami, score 1.3e-06 716540011272 HMMPfam hit to PF00005, ABC transporter, score 2.2e-33 716540011273 PS00017 ATP/GTP-binding site motif A (P-loop). 716540011274 6 transmembrane helices predicted for EAM_2255 by TMHMM2.0 at aa 13-35, 50-72, 120-142, 152-169, 231-253 and 268-290 716540011275 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 716540011276 HMMPfam hit to PF03171, 2OG-Fe(II) oxygenase superfamily, score 0.00084 716540011277 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 716540011278 ApbE family; Region: ApbE; pfam02424 716540011279 HMMPfam hit to PF02424, ApbE family, score 6.6e-127 716540011280 Signal peptide predicted for EAM_2257 by SignalP 2.0 HMM (Signal peptide probability 0.816) with cleavage site probability 0.635 between residues 27 and 28 716540011281 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540011282 Signal peptide predicted for EAM_2258 by SignalP 2.0 HMM (Signal peptide probability 0.983) with cleavage site probability 0.982 between residues 36 and 37 716540011283 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 716540011284 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 716540011285 trimer interface [polypeptide binding]; other site 716540011286 eyelet of channel; other site 716540011287 HMMPfam hit to PF00267, Gram-negative porin, score 2.8e-181 716540011288 PS00576 General diffusion Gram-negative porins signature. 716540011289 Signal peptide predicted for EAM_2259 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.995 between residues 21 and 22 716540011290 2 transmembrane helices predicted for EAM_2260 by TMHMM2.0 at aa 52-74 and 101-123 716540011291 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 716540011292 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716540011293 ATP binding site [chemical binding]; other site 716540011294 Mg2+ binding site [ion binding]; other site 716540011295 G-X-G motif; other site 716540011296 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 716540011297 putative binding surface; other site 716540011298 active site 716540011299 Signal peptide predicted for EAM_2261 by SignalP 2.0 HMM (Signal peptide probability 0.976) with cleavage site probability 0.768 between residues 37 and 38 716540011300 2 transmembrane helices predicted for EAM_2261 by TMHMM2.0 at aa 15-37 and 301-323 716540011301 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 0.0011 716540011302 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 4.4e-06 716540011303 HMMPfam hit to PF01627, Hpt domain, score 6.4e-14 716540011304 transcriptional regulator RcsB; Provisional; Region: PRK10840 716540011305 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716540011306 active site 716540011307 phosphorylation site [posttranslational modification] 716540011308 intermolecular recognition site; other site 716540011309 dimerization interface [polypeptide binding]; other site 716540011310 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 716540011311 DNA binding residues [nucleotide binding] 716540011312 dimerization interface [polypeptide binding]; other site 716540011313 HMMPfam hit to PF00072, Response regulator receiver domain, score 4.2e-29 716540011314 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR fami, score 4.4e-21 716540011315 PS00622 Bacterial regulatory proteins, luxR family signature. 716540011316 Predicted helix-turn-helix motif with score 1130.000, SD 3.04 at aa 166-187, sequence FLVTEIAKKLNRSIKTISSQKK 716540011317 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 716540011318 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 716540011319 dimer interface [polypeptide binding]; other site 716540011320 phosphorylation site [posttranslational modification] 716540011321 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716540011322 ATP binding site [chemical binding]; other site 716540011323 Mg2+ binding site [ion binding]; other site 716540011324 G-X-G motif; other site 716540011325 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 716540011326 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716540011327 active site 716540011328 phosphorylation site [posttranslational modification] 716540011329 intermolecular recognition site; other site 716540011330 dimerization interface [polypeptide binding]; other site 716540011331 HMMPfam hit to PF00072, Response regulator receiver domain, score 6.6e-39 716540011332 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 2.5e-42 716540011333 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 6.7e-21 716540011334 2 transmembrane helices predicted for EAM_2263 by TMHMM2.0 at aa 15-37 and 317-339 716540011335 Signal peptide predicted for EAM_2263 by SignalP 2.0 HMM (Signal peptide probability 0.745) with cleavage site probability 0.278 between residues 37 and 38 716540011336 DNA gyrase subunit A; Validated; Region: PRK05560 716540011337 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 716540011338 CAP-like domain; other site 716540011339 active site 716540011340 primary dimer interface [polypeptide binding]; other site 716540011341 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 716540011342 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 716540011343 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 716540011344 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 716540011345 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 716540011346 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 716540011347 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 9.7e-16 716540011348 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 5.7e-11 716540011349 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 6.2e-16 716540011350 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 2e-09 716540011351 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 3.9e-15 716540011352 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 1.5e-13 716540011353 HMMPfam hit to PF00521, DNA gyrase/topoisomerase IV, subunit A, score 0 716540011354 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 716540011355 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716540011356 S-adenosylmethionine binding site [chemical binding]; other site 716540011357 HMMPfam hit to PF05401, Nodulation protein S (NodS), score 0.00098 716540011358 HMMPfam hit to PF02353, Cyclopropane-fatty-acyl-phospholipid, score 0.00054 716540011359 HMMPfam hit to PF08241, Methyltransferase domain, score 7.4e-28 716540011360 HMMPfam hit to PF08242, Methyltransferase domain, score 1.3e-17 716540011361 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 716540011362 ATP cone domain; Region: ATP-cone; pfam03477 716540011363 Class I ribonucleotide reductase; Region: RNR_I; cd01679 716540011364 active site 716540011365 dimer interface [polypeptide binding]; other site 716540011366 catalytic residues [active] 716540011367 effector binding site; other site 716540011368 R2 peptide binding site; other site 716540011369 HMMPfam hit to PF03477, ATP cone domain, score 3e-21 716540011370 HMMPfam hit to PF00317, Ribonucleotide reductase, all-alpha d, score 1.7e-23 716540011371 HMMPfam hit to PF02867, Ribonucleotide reductase, barrel doma, score 3.5e-261 716540011372 PS00089 Ribonucleotide reductase large subunit signature. 716540011373 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 716540011374 dimer interface [polypeptide binding]; other site 716540011375 putative radical transfer pathway; other site 716540011376 diiron center [ion binding]; other site 716540011377 tyrosyl radical; other site 716540011378 HMMPfam hit to PF00268, Ribonucleotide reductase, small chain, score 1.3e-08 716540011379 PS00368 Ribonucleotide reductase small subunit signature. 716540011380 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 716540011381 catalytic loop [active] 716540011382 iron binding site [ion binding]; other site 716540011383 HMMPfam hit to PF00111, 2Fe-2S iron-sulfur cluster binding domain, score 1.7e-12 716540011384 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 716540011385 hypothetical protein; Provisional; Region: PRK03673 716540011386 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 716540011387 putative MPT binding site; other site 716540011388 Competence-damaged protein; Region: CinA; cl00666 716540011389 HMMPfam hit to PF00994, molybdopterin binding domain, score 1.3e-44 716540011390 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 716540011391 putative catalytic site [active] 716540011392 putative metal binding site [ion binding]; other site 716540011393 putative phosphate binding site [ion binding]; other site 716540011394 HMMPfam hit to PF03372, Endonuclease/Exonuclease/phosphatase fa, score 0.00022 716540011395 3 transmembrane helices predicted for EAM_2271 by TMHMM2.0 at aa 5-27, 32-51 and 56-78 716540011396 Signal peptide predicted for EAM_2271 by SignalP 2.0 HMM (Signal peptide probability 0.677) with cleavage site probability 0.396 between residues 24 and 25 716540011397 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 716540011398 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 716540011399 active site 716540011400 homotetramer interface [polypeptide binding]; other site 716540011401 HMMPfam hit to PF00982, Glycosyltransferase family, score 8e-86 716540011402 PS01067 Protein secE/sec61-gamma signature. 716540011403 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 716540011404 potassium uptake protein; Region: kup; TIGR00794 716540011405 Signal peptide predicted for EAM_2274 by SignalP 2.0 HMM (Signal peptide probability 0.956) with cleavage site probability 0.951 between residues 22 and 23 716540011406 HMMPfam hit to PF02705, K+ potassium transporter, score 1.4e-182 716540011407 12 transmembrane helices predicted for EAM_2274 by TMHMM2.0 at aa 13-32, 47-69, 101-123, 138-157, 168-190, 210-232, 245-267, 287-309, 337-359, 363-385, 392-414 and 419-441 716540011408 HMMPfam hit to PF00860, Permease family, score 0.015 716540011409 hypothetical protein; Provisional; Region: PRK10404 716540011410 HMMPfam hit to PF05957, Bacterial protein of unknown function (DUF88, score 2.1e-42 716540011411 1 transmembrane helix predicted for EAM_2275 by TMHMM2.0 at aa 83-100 716540011412 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 716540011413 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 716540011414 Signal peptide predicted for EAM_2276 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.944 between residues 32 and 33 716540011415 HMMPfam hit to PF04349, Periplasmic glucan biosynthesis protein, Mdo, score 3.7e-166 716540011416 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716540011417 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 716540011418 Coenzyme A binding pocket [chemical binding]; other site 716540011419 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 3.1e-10 716540011420 PS00217 Sugar transport proteins signature 2. 716540011421 10 transmembrane helices predicted for EAM_2278 by TMHMM2.0 at aa 7-29, 39-61, 68-87, 92-114, 127-149, 153-170, 182-204, 281-303, 315-337 and 342-359 716540011422 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 7e-13 716540011423 Signal peptide predicted for EAM_2278 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.570 between residues 26 and 27 716540011424 6 transmembrane helices predicted for EAM_2279 by TMHMM2.0 at aa 20-39, 49-71, 78-95, 101-120, 133-152 and 162-184 716540011425 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 716540011426 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 716540011427 14 transmembrane helices predicted for EAM_2280 by TMHMM2.0 at aa 5-27, 34-56, 76-98, 105-124, 128-147, 159-181, 201-223, 236-258, 268-290, 297-319, 329-351, 371-393, 408-427 and 448-470 716540011428 HMMPfam hit to PF00361, NADH-Ubiquinone/plastoquinone (complex I), score 4.8e-95 716540011429 Signal peptide predicted for EAM_2280 by SignalP 2.0 HMM (Signal peptide probability 0.648) with cleavage site probability 0.179 between residues 26 and 27 716540011430 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 716540011431 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 716540011432 12 transmembrane helices predicted for EAM_2281 by TMHMM2.0 at aa 4-18, 30-49, 85-107, 120-142, 175-197, 218-240, 288-307, 314-336, 341-363, 376-398, 418-440 and 461-483 716540011433 HMMPfam hit to PF00361, NADH-Ubiquinone/plastoquinone (complex I), score 7e-76 716540011434 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 716540011435 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 716540011436 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 716540011437 17 transmembrane helices predicted for EAM_2282 by TMHMM2.0 at aa 4-21, 28-50, 84-106, 113-132, 136-158, 171-193, 213-235, 248-267, 282-300, 307-328, 332-354, 375-397, 412-434, 455-477, 492-514, 526-545 and 589-611 716540011438 HMMPfam hit to PF00361, NADH-Ubiquinone/plastoquinone (complex, score 1.8e-113 716540011439 HMMPfam hit to PF00662, NADH-Ubiquinone oxidoreductase (complex, score 5.3e-27 716540011440 Signal peptide predicted for EAM_2282 by SignalP 2.0 HMM (Signal peptide probability 0.973) with cleavage site probability 0.857 between residues 26 and 27 716540011441 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 716540011442 HMMPfam hit to PF00420, NADH-ubiquinone/plastoquinone oxidoreduct, score 1.1e-29 716540011443 3 transmembrane helices predicted for EAM_2283 by TMHMM2.0 at aa 4-23, 28-50 and 60-82 716540011444 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 716540011445 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 716540011446 HMMPfam hit to PF00499, NADH-ubiquinone/plastoquinone oxidoreduct, score 3.9e-31 716540011447 5 transmembrane helices predicted for EAM_2284 by TMHMM2.0 at aa 4-22, 29-51, 56-78, 91-113 and 133-155 716540011448 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 716540011449 4Fe-4S binding domain; Region: Fer4; pfam00037 716540011450 4Fe-4S binding domain; Region: Fer4; pfam00037 716540011451 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 2.8e-08 716540011452 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 716540011453 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.00013 716540011454 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 716540011455 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 716540011456 8 transmembrane helices predicted for EAM_2286 by TMHMM2.0 at aa 13-35, 81-103, 116-135, 155-177, 184-206, 238-260, 267-289 and 299-321 716540011457 HMMPfam hit to PF00146, NADH dehydrogenase, score 1.2e-163 716540011458 PS00668 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. 716540011459 PS00667 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. 716540011460 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540011461 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 716540011462 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 716540011463 catalytic loop [active] 716540011464 iron binding site [ion binding]; other site 716540011465 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 716540011466 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 716540011467 [4Fe-4S] binding site [ion binding]; other site 716540011468 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 716540011469 HMMPfam hit to PF01568, Molydopterin dinucleotide binding dom, score 0.0019 716540011470 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 do, score 1.3e-12 716540011471 PS00643 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. 716540011472 PS00642 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. 716540011473 HMMPfam hit to PF00111, 2Fe-2S iron-sulfur cluster binding do, score 1.7e-12 716540011474 PS00641 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. 716540011475 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540011476 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 716540011477 SLBB domain; Region: SLBB; pfam10531 716540011478 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 716540011479 PS00645 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. 716540011480 HMMPfam hit to PF01512, Respiratory-chain NADH dehydrogenase, score 1.3e-176 716540011481 PS00644 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. 716540011482 NADH dehydrogenase subunit E; Validated; Region: PRK07539 716540011483 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 716540011484 putative dimer interface [polypeptide binding]; other site 716540011485 [2Fe-2S] cluster binding site [ion binding]; other site 716540011486 HMMPfam hit to PF01257, Respiratory-chain NADH dehydrogenase, score 2e-93 716540011487 PS01099 Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. 716540011488 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 716540011489 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 716540011490 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 716540011491 HMMPfam hit to PF00346, Respiratory-chain NADH dehydrogenase,, score 6.3e-167 716540011492 PS00535 Respiratory chain NADH dehydrogenase 49 Kd subunit signature. 716540011493 HMMPfam hit to PF00329, Respiratory-chain NADH dehydrogenase,, score 4.9e-40 716540011494 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 716540011495 HMMPfam hit to PF01058, NADH ubiquinone oxidoreductase, 20 Kd sub, score 4.1e-52 716540011496 PS01150 Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. 716540011497 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 716540011498 HMMPfam hit to PF00507, NADH-ubiquinone/plastoquinone oxidoreduct, score 2.4e-33 716540011499 3 transmembrane helices predicted for EAM_2292 by TMHMM2.0 at aa 15-37, 66-88 and 98-120 716540011500 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 716540011501 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716540011502 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 716540011503 putative dimerization interface [polypeptide binding]; other site 716540011504 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.2e-30 716540011505 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 716540011506 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 9.2e-16 716540011507 PS00044 Bacterial regulatory proteins, lysR family signature. 716540011508 Predicted helix-turn-helix motif with score 1269.000, SD 3.51 at aa 26-47, sequence NTFAAAATAVCRTQSAVSQQMQ 716540011509 aminotransferase AlaT; Validated; Region: PRK09265 716540011510 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 716540011511 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716540011512 homodimer interface [polypeptide binding]; other site 716540011513 catalytic residue [active] 716540011514 HMMPfam hit to PF00155, Aminotransferase class I and II, score 2.7e-37 716540011515 5'-nucleotidase; Provisional; Region: PRK03826 716540011516 HMMPfam hit to PF01966, HD domain, score 1.1e-14 716540011517 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 716540011518 active site 716540011519 conformational flexibility of ligand binding pocket; other site 716540011520 ADP-ribosylating toxin turn-turn motif; other site 716540011521 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 716540011522 active site 716540011523 conformational flexibility of ligand binding pocket; other site 716540011524 ADP-ribosylating toxin turn-turn motif; other site 716540011525 PS00017 ATP/GTP-binding site motif A (P-loop). 716540011526 putative phosphatase; Provisional; Region: PRK11587 716540011527 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716540011528 motif II; other site 716540011529 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 6.6e-30 716540011530 hypothetical protein; Provisional; Region: PRK01816 716540011531 HMMPfam hit to PF04217, Protein of unknown function, DUF412, score 2.4e-90 716540011532 2 transmembrane helices predicted for EAM_2300 by TMHMM2.0 at aa 45-64 and 68-90 716540011533 propionate/acetate kinase; Provisional; Region: PRK12379 716540011534 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 716540011535 Signal peptide predicted for EAM_2301 by SignalP 2.0 HMM (Signal peptide probability 0.609) with cleavage site probability 0.582 between residues 19 and 20 716540011536 HMMPfam hit to PF00871, Acetokinase family, score 1.5e-240 716540011537 PS01075 Acetate and butyrate kinases family signature 1. 716540011538 PS01076 Acetate and butyrate kinases family signature 2. 716540011539 phosphate acetyltransferase; Reviewed; Region: PRK05632 716540011540 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 716540011541 DRTGG domain; Region: DRTGG; pfam07085 716540011542 phosphate acetyltransferase; Region: pta; TIGR00651 716540011543 HMMPfam hit to PF07085, DRTGG domain, score 2.6e-57 716540011544 HMMPfam hit to PF01515, Phosphate acetyl/butaryl transferase, score 6.5e-187 716540011545 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 716540011546 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 716540011547 Walker A/P-loop; other site 716540011548 ATP binding site [chemical binding]; other site 716540011549 Q-loop/lid; other site 716540011550 ABC transporter signature motif; other site 716540011551 Walker B; other site 716540011552 D-loop; other site 716540011553 H-loop/switch region; other site 716540011554 TOBE domain; Region: TOBE_2; pfam08402 716540011555 HMMPfam hit to PF08402, TOBE domain, score 2e-18 716540011556 HMMPfam hit to PF00005, ABC transporter, score 3e-61 716540011557 PS00211 ABC transporters family signature. 716540011558 PS00017 ATP/GTP-binding site motif A (P-loop). 716540011559 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 716540011560 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 716540011561 DNA-binding site [nucleotide binding]; DNA binding site 716540011562 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 716540011563 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716540011564 homodimer interface [polypeptide binding]; other site 716540011565 catalytic residue [active] 716540011566 HMMPfam hit to PF00155, Aminotransferase class I and II, score 2.6e-07 716540011567 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR fam, score 3.3e-14 716540011568 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 716540011569 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 716540011570 inhibitor-cofactor binding pocket; inhibition site 716540011571 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716540011572 catalytic residue [active] 716540011573 HMMPfam hit to PF00202, Aminotransferase class-III, score 1.9e-138 716540011574 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 716540011575 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 716540011576 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 716540011577 Signal peptide predicted for EAM_2306 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.882 between residues 19 and 20 716540011578 HMMPfam hit to PF01547, Bacterial extracellular solute-binding prot, score 5.1e-05 716540011579 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540011580 dimer interface [polypeptide binding]; other site 716540011581 conserved gate region; other site 716540011582 putative PBP binding loops; other site 716540011583 ABC-ATPase subunit interface; other site 716540011584 6 transmembrane helices predicted for EAM_2307 by TMHMM2.0 at aa 37-59, 207-229, 236-258, 289-311, 344-366 and 388-410 716540011585 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 0.00051 716540011586 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 716540011587 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 716540011588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540011589 dimer interface [polypeptide binding]; other site 716540011590 conserved gate region; other site 716540011591 putative PBP binding loops; other site 716540011592 ABC-ATPase subunit interface; other site 716540011593 Signal peptide predicted for EAM_2308 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.604 between residues 41 and 42 716540011594 6 transmembrane helices predicted for EAM_2308 by TMHMM2.0 at aa 13-35, 74-96, 108-129, 139-161, 182-204 and 239-261 716540011595 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 6.3e-18 716540011596 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 716540011597 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 716540011598 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 716540011599 nudix motif; other site 716540011600 HMMPfam hit to PF00293, NUDIX domain, score 2e-22 716540011601 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 716540011602 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 716540011603 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 716540011604 putative NAD(P) binding site [chemical binding]; other site 716540011605 putative active site [active] 716540011606 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase family, score 1.3e-11 716540011607 HMMPfam hit to PF08338, Domain of unknown function (DUF1731), score 5.3e-23 716540011608 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 716540011609 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 716540011610 Walker A/P-loop; other site 716540011611 ATP binding site [chemical binding]; other site 716540011612 Q-loop/lid; other site 716540011613 ABC transporter signature motif; other site 716540011614 Walker B; other site 716540011615 D-loop; other site 716540011616 H-loop/switch region; other site 716540011617 HMMPfam hit to PF00005, ABC transporter, score 7.3e-65 716540011618 PS00211 ABC transporters family signature. 716540011619 PS00017 ATP/GTP-binding site motif A (P-loop). 716540011620 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 716540011621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540011622 dimer interface [polypeptide binding]; other site 716540011623 conserved gate region; other site 716540011624 putative PBP binding loops; other site 716540011625 ABC-ATPase subunit interface; other site 716540011626 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 4e-15 716540011627 3 transmembrane helices predicted for EAM_2314 by TMHMM2.0 at aa 24-46, 59-81 and 199-221 716540011628 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 716540011629 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 716540011630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540011631 dimer interface [polypeptide binding]; other site 716540011632 conserved gate region; other site 716540011633 putative PBP binding loops; other site 716540011634 ABC-ATPase subunit interface; other site 716540011635 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.1e-28 716540011636 5 transmembrane helices predicted for EAM_2315 by TMHMM2.0 at aa 15-37, 54-76, 86-108, 149-171 and 191-213 716540011637 PS00017 ATP/GTP-binding site motif A (P-loop). 716540011638 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 716540011639 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 716540011640 substrate binding pocket [chemical binding]; other site 716540011641 membrane-bound complex binding site; other site 716540011642 hinge residues; other site 716540011643 HMMPfam hit to PF00497, Bacterial extracellular solute-binding prot, score 2e-92 716540011644 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 716540011645 1 transmembrane helix predicted for EAM_2316 by TMHMM2.0 at aa 5-24 716540011646 Signal peptide predicted for EAM_2316 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 22 and 23 716540011647 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 716540011648 Flavoprotein; Region: Flavoprotein; pfam02441 716540011649 HMMPfam hit to PF02441, Flavoprotein, score 1.2e-46 716540011650 amidophosphoribosyltransferase; Provisional; Region: PRK09246 716540011651 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 716540011652 active site 716540011653 tetramer interface [polypeptide binding]; other site 716540011654 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 716540011655 active site 716540011656 HMMPfam hit to PF00156, Phosphoribosyl transferase domain, score 7.8e-13 716540011657 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 716540011658 HMMPfam hit to PF00310, Glutamine amidotransferases class-II, score 3.3e-61 716540011659 PS00443 Glutamine amidotransferases class-II active site. 716540011660 colicin V production protein; Provisional; Region: PRK10845 716540011661 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 716540011662 HMMPfam hit to PF02674, Colicin V production protein, score 1.1e-56 716540011663 4 transmembrane helices predicted for EAM_2319 by TMHMM2.0 at aa 4-26, 31-53, 63-85 and 98-120 716540011664 sulfite reductase; Provisional; Region: PRK06214 716540011665 cell division protein DedD; Provisional; Region: PRK11633 716540011666 Sporulation related domain; Region: SPOR; pfam05036 716540011667 HMMPfam hit to PF05036, Sporulation related domain, score 7.1e-14 716540011668 1 transmembrane helix predicted for EAM_2321 by TMHMM2.0 at aa 7-29 716540011669 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 716540011670 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 716540011671 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 716540011672 HMMPfam hit to PF02875, Mur ligase family, glutamate ligase doma, score 0.00017 716540011673 HMMPfam hit to PF08245, Mur ligase middle domain, score 3e-06 716540011674 PS01012 Folylpolyglutamate synthase signature 2. 716540011675 PS01011 Folylpolyglutamate synthase signature 1. 716540011676 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 716540011677 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 716540011678 Predicted helix-turn-helix motif with score 1104.000, SD 2.95 at aa 1026-1047, sequence TQAEFLAEKLGMKKGAVNSYLQ 716540011679 PS00018 EF-hand calcium-binding domain. 716540011680 hypothetical protein; Provisional; Region: PRK10847 716540011681 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 716540011682 4 transmembrane helices predicted for EAM_2325 by TMHMM2.0 at aa 27-49, 71-93, 156-178 and 191-208 716540011683 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 716540011684 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 716540011685 dimerization interface 3.5A [polypeptide binding]; other site 716540011686 active site 716540011687 HMMPfam hit to PF01416, tRNA pseudouridine synthase, score 6.6e-28 716540011688 HMMPfam hit to PF01416, tRNA pseudouridine synthase, score 1.3e-38 716540011689 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 716540011690 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 716540011691 HMMPfam hit to PF02774, Semialdehyde dehydrogenase, dimerisat, score 7.3e-39 716540011692 HMMPfam hit to PF01118, Semialdehyde dehydrogenase, NAD bindi, score 7.1e-35 716540011693 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 716540011694 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 716540011695 ligand binding site [chemical binding]; other site 716540011696 NAD binding site [chemical binding]; other site 716540011697 catalytic site [active] 716540011698 homodimer interface [polypeptide binding]; other site 716540011699 HMMPfam hit to PF00389, D-isomer specific 2-hydroxyacid dehydrog, score 8.9e-26 716540011700 HMMPfam hit to PF02826, D-isomer specific 2-hydroxyacid dehydrog, score 1.1e-22 716540011701 PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 716540011702 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 716540011703 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 716540011704 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716540011705 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716540011706 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 4.1e-06 716540011707 PS00041 Bacterial regulatory proteins, araC family signature. 716540011708 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 5.9e-06 716540011709 Predicted helix-turn-helix motif with score 1659.000, SD 4.84 at aa 174-195, sequence TTLAQWAQRVFTSERTLSRRCQ 716540011710 EamA-like transporter family; Region: EamA; pfam00892 716540011711 EamA-like transporter family; Region: EamA; pfam00892 716540011712 Signal peptide predicted for EAM_2330 by SignalP 2.0 HMM (Signal peptide probability 0.707) with cleavage site probability 0.192 between residues 24 and 25 716540011713 10 transmembrane helices predicted for EAM_2330 by TMHMM2.0 at aa 5-27, 31-53, 66-85, 90-112, 119-136, 151-168, 181-200, 210-229, 242-259 and 263-281 716540011714 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 4.4e-19 716540011715 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 8.7e-20 716540011716 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 716540011717 1 transmembrane helix predicted for EAM_2331 by TMHMM2.0 at aa 322-344 716540011718 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 716540011719 active site residue [active] 716540011720 HMMPfam hit to PF00581, Rhodanese-like domain, score 1.7e-06 716540011721 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 716540011722 DNA-binding site [nucleotide binding]; DNA binding site 716540011723 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 716540011724 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 716540011725 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716540011726 homodimer interface [polypeptide binding]; other site 716540011727 catalytic residue [active] 716540011728 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR fam, score 2.8e-18 716540011729 HMMPfam hit to PF00155, Aminotransferase class I and II, score 1e-08 716540011730 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 716540011731 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 716540011732 catalytic residue [active] 716540011733 1 transmembrane helix predicted for EAM_2335 by TMHMM2.0 at aa 21-43 716540011734 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 716540011735 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 716540011736 dimer interface [polypeptide binding]; other site 716540011737 active site 716540011738 HMMPfam hit to PF02801, Beta-ketoacyl synthase, C-terminal do, score 7.2e-60 716540011739 HMMPfam hit to PF00109, Beta-ketoacyl synthase, N-terminal do, score 1.1e-58 716540011740 PS00606 Beta-ketoacyl synthases active site. 716540011741 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 716540011742 Uncharacterized conserved protein [Function unknown]; Region: COG4121 716540011743 HMMPfam hit to PF05430, Protein of unknown function (DUF752), score 3e-129 716540011744 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 1.3e-56 716540011745 YfcL protein; Region: YfcL; pfam08891 716540011746 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 716540011747 HMMPfam hit to PF04315, Protein of unknown function, DUF462, score 1.7e-130 716540011748 hypothetical protein; Provisional; Region: PRK10621 716540011749 Predicted permeases [General function prediction only]; Region: COG0730 716540011750 HMMPfam hit to PF01925, Domain of unknown function DUF81, score 4.4e-58 716540011751 7 transmembrane helices predicted for EAM_2340 by TMHMM2.0 at aa 5-27, 47-69, 81-100, 104-123, 135-154, 159-176 and 189-211 716540011752 Signal peptide predicted for EAM_2340 by SignalP 2.0 HMM (Signal peptide probability 0.952) with cleavage site probability 0.494 between residues 41 and 42 716540011753 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 716540011754 HMMPfam hit to PF03411, Penicillin-insensitive murein endopepti, score 3.2e-153 716540011755 Signal peptide predicted for EAM_2341 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.915 between residues 17 and 18 716540011756 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 716540011757 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 716540011758 Tetramer interface [polypeptide binding]; other site 716540011759 active site 716540011760 FMN-binding site [chemical binding]; other site 716540011761 HMMPfam hit to PF01264, Chorismate synthase, score 1.5e-230 716540011762 PS00789 Chorismate synthase signature 3. 716540011763 PS00788 Chorismate synthase signature 2. 716540011764 PS00787 Chorismate synthase signature 1. 716540011765 HemK family putative methylases; Region: hemK_fam; TIGR00536 716540011766 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716540011767 S-adenosylmethionine binding site [chemical binding]; other site 716540011768 HMMPfam hit to PF05175, Methyltransferase small domain, score 1.5e-08 716540011769 PS00092 N-6 Adenine-specific DNA methylases signature. 716540011770 hypothetical protein; Provisional; Region: PRK04946 716540011771 Smr domain; Region: Smr; pfam01713 716540011772 HMMPfam hit to PF01713, Smr domain, score 4.8e-31 716540011773 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 716540011774 catalytic core [active] 716540011775 HMMPfam hit to PF00300, Phosphoglycerate mutase family, score 4.2e-10 716540011776 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 716540011777 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 716540011778 substrate binding site [chemical binding]; other site 716540011779 oxyanion hole (OAH) forming residues; other site 716540011780 trimer interface [polypeptide binding]; other site 716540011781 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 716540011782 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 716540011783 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 716540011784 HMMPfam hit to PF00725, 3-hydroxyacyl-CoA dehydrogenase, C-terminal, score 0.00029 716540011785 HMMPfam hit to PF00725, 3-hydroxyacyl-CoA dehydrogenase, C-terminal, score 1e-33 716540011786 PS00067 3-hydroxyacyl-CoA dehydrogenase signature. 716540011787 HMMPfam hit to PF02737, 3-hydroxyacyl-CoA dehydrogenase, NAD binding, score 4.6e-79 716540011788 HMMPfam hit to PF00378, Enoyl-CoA hydratase/isomerase family, score 3.3e-53 716540011789 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 716540011790 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 716540011791 dimer interface [polypeptide binding]; other site 716540011792 active site 716540011793 HMMPfam hit to PF02803, Thiolase, C-terminal domain, score 1.2e-45 716540011794 PS00099 Thiolases active site. 716540011795 PS00737 Thiolases signature 2. 716540011796 HMMPfam hit to PF00108, Thiolase, N-terminal domain, score 1.9e-55 716540011797 PS00098 Thiolases acyl-enzyme intermediate signature. 716540011798 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 716540011799 Signal peptide predicted for EAM_2348 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 25 and 26 716540011800 HMMPfam hit to PF03349, Outer membrane protein transport protein (O, score 4.8e-168 716540011801 PS00017 ATP/GTP-binding site motif A (P-loop). 716540011802 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 716540011803 HMMPfam hit to PF04333, VacJ like lipoprotein, score 4.9e-110 716540011804 Signal peptide predicted for EAM_2349 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.719 between residues 24 and 25 716540011805 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540011806 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 716540011807 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 716540011808 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 716540011809 binding surface 716540011810 TPR motif; other site 716540011811 2 transmembrane helices predicted for EAM_2350 by TMHMM2.0 at aa 4-26 and 91-113 716540011812 Signal peptide predicted for EAM_2350 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.621 between residues 31 and 32 716540011813 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540011814 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 716540011815 HMMPfam hit to PF03918, Cytochrome C biogenesis protein, score 9.8e-57 716540011816 2 transmembrane helices predicted for EAM_2351 by TMHMM2.0 at aa 5-27 and 101-123 716540011817 Signal peptide predicted for EAM_2351 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.993 between residues 19 and 20 716540011818 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540011819 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 716540011820 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 716540011821 HMMPfam hit to PF08534, Redoxin, score 6e-26 716540011822 PS00194 Thioredoxin family active site. 716540011823 Signal peptide predicted for EAM_2352 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.745 between residues 28 and 29 716540011824 1 transmembrane helix predicted for EAM_2352 by TMHMM2.0 at aa 5-24 716540011825 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 716540011826 15 transmembrane helices predicted for EAM_2353 by TMHMM2.0 at aa 5-27, 40-62, 95-114, 121-143, 176-198, 211-233, 248-265, 277-299, 314-332, 353-375, 390-412, 425-444, 448-470, 490-512 and 617-636 716540011827 HMMPfam hit to PF01578, Cytochrome C assembly protein, score 1.5e-86 716540011828 PS00340 Growth factor and cytokines receptors family signature 2. 716540011829 Signal peptide predicted for EAM_2353 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.868 between residues 22 and 23 716540011830 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 716540011831 HMMPfam hit to PF03100, CcmE, score 4.7e-81 716540011832 Signal peptide predicted for EAM_2354 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.532 between residues 31 and 32 716540011833 1 transmembrane helix predicted for EAM_2354 by TMHMM2.0 at aa 7-29 716540011834 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 716540011835 HMMPfam hit to PF04995, Heme exporter protein D (CcmD), score 2.3e-18 716540011836 1 transmembrane helix predicted for EAM_2355 by TMHMM2.0 at aa 15-37 716540011837 heme exporter protein CcmC; Region: ccmC; TIGR01191 716540011838 6 transmembrane helices predicted for EAM_2356 by TMHMM2.0 at aa 21-43, 63-85, 92-114, 124-146, 158-180 and 205-227 716540011839 HMMPfam hit to PF01578, Cytochrome C assembly protein, score 2.1e-56 716540011840 heme exporter protein CcmB; Region: ccmB; TIGR01190 716540011841 HMMPfam hit to PF03379, CcmB protein, score 2.1e-117 716540011842 6 transmembrane helices predicted for EAM_2357 by TMHMM2.0 at aa 20-39, 43-65, 98-120, 130-152, 157-179 and 194-216 716540011843 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 716540011844 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 716540011845 Walker A/P-loop; other site 716540011846 ATP binding site [chemical binding]; other site 716540011847 Q-loop/lid; other site 716540011848 ABC transporter signature motif; other site 716540011849 Walker B; other site 716540011850 D-loop; other site 716540011851 H-loop/switch region; other site 716540011852 HMMPfam hit to PF00005, ABC transporter, score 8.3e-38 716540011853 PS00211 ABC transporters family signature. 716540011854 PS00017 ATP/GTP-binding site motif A (P-loop). 716540011855 BetR domain; Region: BetR; pfam08667 716540011856 Response regulator receiver domain; Region: Response_reg; pfam00072 716540011857 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716540011858 active site 716540011859 phosphorylation site [posttranslational modification] 716540011860 intermolecular recognition site; other site 716540011861 dimerization interface [polypeptide binding]; other site 716540011862 HMMPfam hit to PF00072, Response regulator receiver domain, score 5.1e-05 716540011863 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 716540011864 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716540011865 Coenzyme A binding pocket [chemical binding]; other site 716540011866 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1.6e-13 716540011867 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 716540011868 Signal peptide predicted for EAM_2361 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.966 between residues 18 and 19 716540011869 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 716540011870 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716540011871 ATP binding site [chemical binding]; other site 716540011872 Mg2+ binding site [ion binding]; other site 716540011873 G-X-G motif; other site 716540011874 Signal peptide predicted for EAM_2362 by SignalP 2.0 HMM (Signal peptide probability 0.633) with cleavage site probability 0.376 between residues 21 and 22 716540011875 2 transmembrane helices predicted for EAM_2362 by TMHMM2.0 at aa 5-24 and 172-189 716540011876 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 0.012 716540011877 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 1.5e-23 716540011878 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 716540011879 Mechanosensitive ion channel; Region: MS_channel; pfam00924 716540011880 HMMPfam hit to PF00924, Mechanosensitive ion channel, score 1.8e-48 716540011881 4 transmembrane helices predicted for EAM_2363 by TMHMM2.0 at aa 18-40, 96-118, 138-160 and 165-182 716540011882 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 716540011883 Signal peptide predicted for EAM_2365 by SignalP 2.0 HMM (Signal peptide probability 0.962) with cleavage site probability 0.427 between residues 27 and 28 716540011884 2 transmembrane helices predicted for EAM_2365 by TMHMM2.0 at aa 7-25 and 40-62 716540011885 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 716540011886 HMMPfam hit to PF08450, SMP-30/Gluconolaconase/LRE-like region, score 4.1e-37 716540011887 HMMPfam hit to PF03758, Senescence marker protein-30 (SMP-30), N-ter, score 3.4e-26 716540011888 Outer membrane lipoprotein Slp family; Region: Slp; cl01164 716540011889 1 transmembrane helix predicted for EAM_2367 by TMHMM2.0 at aa 55-77 716540011890 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540011891 Signal peptide predicted for EAM_2368 by SignalP 2.0 HMM (Signal peptide probability 0.807) with cleavage site probability 0.394 between residues 43 and 44 716540011892 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540011893 1 transmembrane helix predicted for EAM_2369 by TMHMM2.0 at aa 15-37 716540011894 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 716540011895 Ligand Binding Site [chemical binding]; other site 716540011896 HMMPfam hit to PF00582, Universal stress protein family, score 8.7e-13 716540011897 PS00017 ATP/GTP-binding site motif A (P-loop). 716540011898 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 716540011899 SopA-like central domain; Region: SopA; pfam13981 716540011900 SopA-like catalytic domain; Region: SopA_C; pfam13979 716540011901 aminotransferase; Validated; Region: PRK08175 716540011902 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 716540011903 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716540011904 homodimer interface [polypeptide binding]; other site 716540011905 catalytic residue [active] 716540011906 HMMPfam hit to PF00155, Aminotransferase class I and II, score 6.1e-58 716540011907 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 716540011908 glucokinase; Provisional; Region: glk; PRK00292 716540011909 glucokinase, proteobacterial type; Region: glk; TIGR00749 716540011910 HMMPfam hit to PF02685, Glucokinase, score 5.9e-187 716540011911 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 716540011912 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 716540011913 dimer interface [polypeptide binding]; other site 716540011914 PYR/PP interface [polypeptide binding]; other site 716540011915 TPP binding site [chemical binding]; other site 716540011916 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 716540011917 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 716540011918 TPP-binding site [chemical binding]; other site 716540011919 dimer interface [polypeptide binding]; other site 716540011920 HMMPfam hit to PF02775, Thiamine pyrophosphate enzyme, C-termina, score 4.6e-16 716540011921 PS00187 Thiamine pyrophosphate enzymes signature. 716540011922 HMMPfam hit to PF00205, Thiamine pyrophosphate enzyme, central d, score 3.2e-14 716540011923 PS00017 ATP/GTP-binding site motif A (P-loop). 716540011924 HMMPfam hit to PF02776, Thiamine pyrophosphate enzyme, N-termina, score 3.7e-69 716540011925 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 716540011926 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 716540011927 active site 716540011928 catalytic tetrad [active] 716540011929 HMMPfam hit to PF00248, Aldo/keto reductase family, score 1.3e-63 716540011930 Signal peptide predicted for EAM_2377 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.943 between residues 24 and 25 716540011931 manganese transport protein MntH; Reviewed; Region: PRK00701 716540011932 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 716540011933 11 transmembrane helices predicted for EAM_2378 by TMHMM2.0 at aa 17-39, 54-76, 96-118, 123-145, 152-174, 197-219, 240-262, 289-311, 318-340, 350-372 and 389-411 716540011934 HMMPfam hit to PF01566, Natural resistance-associated macrophage pro, score 4.6e-178 716540011935 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 716540011936 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 716540011937 Nucleoside recognition; Region: Gate; pfam07670 716540011938 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 716540011939 Signal peptide predicted for EAM_2379 by SignalP 2.0 HMM (Signal peptide probability 0.759) with cleavage site probability 0.293 between residues 23 and 24 716540011940 HMMPfam hit to PF01773, Na+ dependent nucleoside transporter N, score 6.9e-31 716540011941 9 transmembrane helices predicted for EAM_2379 by TMHMM2.0 at aa 4-21, 28-47, 86-108, 167-189, 193-215, 241-263, 273-295, 334-356 and 371-393 716540011942 HMMPfam hit to PF07670, Nucleoside recognition, score 2e-17 716540011943 HMMPfam hit to PF07662, Na+ dependent nucleoside transporter C, score 3.9e-103 716540011944 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 716540011945 HMMPfam hit to PF01226, Formate/nitrite transporter, score 3.2e-51 716540011946 6 transmembrane helices predicted for EAM_2380 by TMHMM2.0 at aa 25-47, 62-84, 105-127, 154-176, 197-219 and 229-251 716540011947 PS01006 Formate and nitrite transporters signature 2. 716540011948 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 716540011949 HMMPfam hit to PF07037, Protein of unknown function (DUF1323), score 1e-43 716540011950 Predicted helix-turn-helix motif with score 2112.000, SD 6.38 at aa 6-27, sequence LTPEELAQQTGFSRQTINKWVK 716540011951 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 716540011952 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 716540011953 active site 716540011954 HIGH motif; other site 716540011955 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 716540011956 active site 716540011957 KMSKS motif; other site 716540011958 HMMPfam hit to PF00749, tRNA synthetases class I (E and Q), cata, score 1.3e-176 716540011959 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 716540011960 Predicted helix-turn-helix motif with score 1027.000, SD 2.68 at aa 46-67, sequence LTEQQKAEQLQMTENQIAMLEA 716540011961 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716540011962 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716540011963 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 716540011964 putative dimerization interface [polypeptide binding]; other site 716540011965 HMMPfam hit to PF03466, LysR substrate binding domain, score 4.3e-44 716540011966 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 2.1e-23 716540011967 PS00044 Bacterial regulatory proteins, lysR family signature. 716540011968 Predicted helix-turn-helix motif with score 1747.000, SD 5.14 at aa 18-39, sequence GSFSQAGQLIGLSQSAVSHSIK 716540011969 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 716540011970 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 716540011971 8 transmembrane helices predicted for EAM_2385 by TMHMM2.0 at aa 13-30, 35-53, 66-88, 98-120, 125-147, 203-222, 229-251 and 278-300 716540011972 HMMPfam hit to PF01758, Sodium Bile acid symporter family, score 0.00065 716540011973 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 716540011974 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 716540011975 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 716540011976 nucleotide binding pocket [chemical binding]; other site 716540011977 K-X-D-G motif; other site 716540011978 catalytic site [active] 716540011979 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 716540011980 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 716540011981 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 716540011982 Dimer interface [polypeptide binding]; other site 716540011983 BRCT sequence motif; other site 716540011984 HMMPfam hit to PF00533, BRCA1 C Terminus (BRCT) domain, score 2.9e-20 716540011985 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 0.0011 716540011986 HMMPfam hit to PF03119, NAD-dependent DNA ligase C4 zinc fing, score 2.2e-12 716540011987 HMMPfam hit to PF03120, NAD-dependent DNA ligase OB-fold doma, score 3e-45 716540011988 PS01056 NAD-dependent DNA ligase signature 2. 716540011989 HMMPfam hit to PF01653, NAD-dependent DNA ligase adenylation, score 9.2e-198 716540011990 PS01055 NAD-dependent DNA ligase signature 1. 716540011991 cell division protein ZipA; Provisional; Region: PRK03427 716540011992 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 716540011993 FtsZ protein binding site [polypeptide binding]; other site 716540011994 HMMPfam hit to PF04354, ZipA, C-terminal FtsZ-binding domain, score 1.8e-76 716540011995 1 transmembrane helix predicted for EAM_2388 by TMHMM2.0 at aa 7-26 716540011996 Signal peptide predicted for EAM_2388 by SignalP 2.0 HMM (Signal peptide probability 0.624) with cleavage site probability 0.608 between residues 23 and 24 716540011997 putative sulfate transport protein CysZ; Validated; Region: PRK04949 716540011998 4 transmembrane helices predicted for EAM_2389 by TMHMM2.0 at aa 28-50, 71-93, 152-174 and 212-234 716540011999 HMMPfam hit to PF04401, Protein of unknown function (DUF540), score 4.8e-97 716540012000 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 716540012001 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 716540012002 dimer interface [polypeptide binding]; other site 716540012003 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716540012004 catalytic residue [active] 716540012005 HMMPfam hit to PF00291, Pyridoxal-phosphate dependent enzyme, score 1.9e-127 716540012006 PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. 716540012007 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 716540012008 dimerization domain swap beta strand [polypeptide binding]; other site 716540012009 regulatory protein interface [polypeptide binding]; other site 716540012010 active site 716540012011 regulatory phosphorylation site [posttranslational modification]; other site 716540012012 HMMPfam hit to PF00381, PTS HPr component phosphorylation site, score 7.8e-47 716540012013 PS00369 PTS HPR component histidine phosphorylation site signature. 716540012014 PS00589 PTS HPR component serine phosphorylation site signature. 716540012015 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 716540012016 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 716540012017 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 716540012018 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 716540012019 HMMPfam hit to PF05524, PEP-utilising enzyme, N-terminal, score 1.9e-57 716540012020 HMMPfam hit to PF00391, PEP-utilising enzyme, mobile domain, score 5.5e-34 716540012021 PS00370 PEP-utilizing enzymes phosphorylation site signature. 716540012022 HMMPfam hit to PF02896, PEP-utilising enzyme, TIM barrel doma, score 2.1e-185 716540012023 PS00742 PEP-utilizing enzymes signature 2. 716540012024 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 716540012025 HPr interaction site; other site 716540012026 glycerol kinase (GK) interaction site [polypeptide binding]; other site 716540012027 active site 716540012028 phosphorylation site [posttranslational modification] 716540012029 HMMPfam hit to PF00358, phosphoenolpyruvate-dependent sugar phosph, score 1.5e-78 716540012030 PS00371 PTS EIIA domains phosphorylation site signature 1. 716540012031 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 716540012032 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 716540012033 dimerization interface [polypeptide binding]; other site 716540012034 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 716540012035 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 716540012036 dimer interface [polypeptide binding]; other site 716540012037 phosphorylation site [posttranslational modification] 716540012038 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716540012039 ATP binding site [chemical binding]; other site 716540012040 Mg2+ binding site [ion binding]; other site 716540012041 G-X-G motif; other site 716540012042 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 7.3e-31 716540012043 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 1.7e-15 716540012044 HMMPfam hit to PF00672, HAMP domain, score 1.1e-13 716540012045 2 transmembrane helices predicted for EAM_2394 by TMHMM2.0 at aa 13-35 and 155-177 716540012046 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 716540012047 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716540012048 active site 716540012049 phosphorylation site [posttranslational modification] 716540012050 intermolecular recognition site; other site 716540012051 dimerization interface [polypeptide binding]; other site 716540012052 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 716540012053 DNA binding site [nucleotide binding] 716540012054 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 4e-16 716540012055 HMMPfam hit to PF00072, Response regulator receiver domain, score 5.4e-31 716540012056 cysteine synthase B; Region: cysM; TIGR01138 716540012057 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 716540012058 dimer interface [polypeptide binding]; other site 716540012059 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716540012060 catalytic residue [active] 716540012061 HMMPfam hit to PF00291, Pyridoxal-phosphate dependent enzyme, score 4e-107 716540012062 PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. 716540012063 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 716540012064 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 716540012065 Walker A/P-loop; other site 716540012066 ATP binding site [chemical binding]; other site 716540012067 Q-loop/lid; other site 716540012068 ABC transporter signature motif; other site 716540012069 Walker B; other site 716540012070 D-loop; other site 716540012071 H-loop/switch region; other site 716540012072 HMMPfam hit to PF00005, ABC transporter, score 3.4e-71 716540012073 PS00211 ABC transporters family signature. 716540012074 PS00017 ATP/GTP-binding site motif A (P-loop). 716540012075 sulfate transport protein; Provisional; Region: cysT; CHL00187 716540012076 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540012077 dimer interface [polypeptide binding]; other site 716540012078 conserved gate region; other site 716540012079 putative PBP binding loops; other site 716540012080 ABC-ATPase subunit interface; other site 716540012081 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 4.7e-14 716540012082 6 transmembrane helices predicted for EAM_2398 by TMHMM2.0 at aa 21-43, 69-91, 103-125, 140-162, 201-223 and 250-272 716540012083 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 716540012084 Signal peptide predicted for EAM_2398 by SignalP 2.0 HMM (Signal peptide probability 0.733) with cleavage site probability 0.368 between residues 47 and 48 716540012085 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 716540012086 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540012087 dimer interface [polypeptide binding]; other site 716540012088 conserved gate region; other site 716540012089 putative PBP binding loops; other site 716540012090 ABC-ATPase subunit interface; other site 716540012091 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 3e-36 716540012092 7 transmembrane helices predicted for EAM_2399 by TMHMM2.0 at aa 15-37, 62-84, 104-126, 138-160, 188-205, 212-234 and 244-266 716540012093 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 716540012094 Signal peptide predicted for EAM_2399 by SignalP 2.0 HMM (Signal peptide probability 0.924) with cleavage site probability 0.486 between residues 45 and 46 716540012095 thiosulfate transporter subunit; Provisional; Region: PRK10852 716540012096 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 716540012097 HMMPfam hit to PF01547, Bacterial extracellular solute-binding prot, score 8.1e-05 716540012098 Signal peptide predicted for EAM_2400 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.974 between residues 25 and 26 716540012099 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 716540012100 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 716540012101 HMMPfam hit to PF06572, Protein of unknown function (DUF1131), score 2.1e-101 716540012102 Signal peptide predicted for EAM_2401 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.718 between residues 23 and 24 716540012103 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540012104 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 716540012105 3 transmembrane helices predicted for EAM_2402 by TMHMM2.0 at aa 26-48, 63-85 and 98-115 716540012106 putative acetyltransferase; Provisional; Region: PRK03624 716540012107 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716540012108 Coenzyme A binding pocket [chemical binding]; other site 716540012109 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1.3e-19 716540012110 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 716540012111 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 716540012112 active site 716540012113 metal binding site [ion binding]; metal-binding site 716540012114 Signal peptide predicted for EAM_2404 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.852 between residues 35 and 36 716540012115 HMMPfam hit to PF01520, N-acetylmuramoyl-L-alanine amidase, score 5.1e-91 716540012116 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 716540012117 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 716540012118 HMMPfam hit to PF01218, Coproporphyrinogen III oxidase, score 6.9e-226 716540012119 PS01021 Coproporphyrinogen III oxidase signature. 716540012120 1 transmembrane helix predicted for EAM_2406 by TMHMM2.0 at aa 5-27 716540012121 transaldolase-like protein; Provisional; Region: PTZ00411 716540012122 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 716540012123 active site 716540012124 dimer interface [polypeptide binding]; other site 716540012125 catalytic residue [active] 716540012126 HMMPfam hit to PF00923, Transaldolase, score 5.9e-157 716540012127 PS01054 Transaldolase signature 1. 716540012128 PS00958 Transaldolase active site. 716540012129 transketolase; Reviewed; Region: PRK12753 716540012130 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 716540012131 TPP-binding site [chemical binding]; other site 716540012132 dimer interface [polypeptide binding]; other site 716540012133 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 716540012134 PYR/PP interface [polypeptide binding]; other site 716540012135 dimer interface [polypeptide binding]; other site 716540012136 TPP binding site [chemical binding]; other site 716540012137 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 716540012138 HMMPfam hit to PF00456, Transketolase, thiamine diphosphate b, score 7e-251 716540012139 PS00801 Transketolase signature 1. 716540012140 HMMPfam hit to PF02779, Transketolase, pyridine binding domai, score 6.8e-65 716540012141 PS00802 Transketolase signature 2. 716540012142 HMMPfam hit to PF02780, Transketolase, C-terminal domain, score 3e-14 716540012143 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 716540012144 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 716540012145 dimer interface [polypeptide binding]; other site 716540012146 ADP-ribose binding site [chemical binding]; other site 716540012147 active site 716540012148 nudix motif; other site 716540012149 metal binding site [ion binding]; metal-binding site 716540012150 HMMPfam hit to PF00293, NUDIX domain, score 5e-18 716540012151 PS00017 ATP/GTP-binding site motif A (P-loop). 716540012152 L-asparagine permease; Provisional; Region: PRK15049 716540012153 HMMPfam hit to PF00324, Amino acid permease, score 7.1e-160 716540012154 12 transmembrane helices predicted for EAM_2410 by TMHMM2.0 at aa 37-59, 64-86, 107-129, 144-166, 171-193, 218-240, 260-282, 302-324, 351-373, 377-399, 420-442 and 446-468 716540012155 PS00218 Amino acid permeases signature. 716540012156 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 716540012157 HMMPfam hit to PF07338, Protein of unknown function (DUF1471), score 1e-23 716540012158 Signal peptide predicted for EAM_2411 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 23 and 24 716540012159 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 716540012160 Histidine kinase; Region: HisKA_3; pfam07730 716540012161 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716540012162 ATP binding site [chemical binding]; other site 716540012163 Mg2+ binding site [ion binding]; other site 716540012164 G-X-G motif; other site 716540012165 Signal peptide predicted for EAM_2412 by SignalP 2.0 HMM (Signal peptide probability 0.798) with cleavage site probability 0.605 between residues 33 and 34 716540012166 HMMPfam hit to PF07730, Histidine kinase, score 4.5e-14 716540012167 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 1.1e-14 716540012168 transcriptional regulator NarP; Provisional; Region: PRK10403 716540012169 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716540012170 active site 716540012171 phosphorylation site [posttranslational modification] 716540012172 intermolecular recognition site; other site 716540012173 dimerization interface [polypeptide binding]; other site 716540012174 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 716540012175 DNA binding residues [nucleotide binding] 716540012176 dimerization interface [polypeptide binding]; other site 716540012177 HMMPfam hit to PF00072, Response regulator receiver domain, score 4.2e-32 716540012178 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR fami, score 1e-24 716540012179 PS00622 Bacterial regulatory proteins, luxR family signature. 716540012180 Predicted helix-turn-helix motif with score 1474.000, SD 4.21 at aa 165-186, sequence LPNKQVAENLAISEQTVKVHIR 716540012181 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 716540012182 Protein export membrane protein; Region: SecD_SecF; cl14618 716540012183 HMMPfam hit to PF00873, AcrB/AcrD/AcrF family, score 0 716540012184 11 transmembrane helices predicted for EAM_2414 by TMHMM2.0 at aa 10-32, 340-362, 366-388, 438-460, 470-492, 537-556, 868-890, 897-919, 924-946, 972-994 and 1004-1026 716540012185 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 716540012186 ArsC family; Region: ArsC; pfam03960 716540012187 putative catalytic residues [active] 716540012188 HMMPfam hit to PF03960, ArsC family, score 3.5e-41 716540012189 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 716540012190 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 716540012191 metal binding site [ion binding]; metal-binding site 716540012192 dimer interface [polypeptide binding]; other site 716540012193 PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 716540012194 HMMPfam hit to PF01546, Peptidase family M20/M25/M40, score 4.1e-50 716540012195 PS00759 ArgE / dapE / ACY1 / CPG2 / yscS family signature 2. 716540012196 HMMPfam hit to PF07687, Peptidase dimerisation domain, score 9.6e-31 716540012197 hypothetical protein; Provisional; Region: PRK13664 716540012198 1 transmembrane helix predicted for EAM_2419 by TMHMM2.0 at aa 7-24 716540012199 Condensation domain; Region: Condensation; pfam00668 716540012200 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 716540012201 C-terminal subdomain of the Formyltransferase-like domain found in OzmH-like proteins; Region: FMT_C_OzmH_like; cd08700 716540012202 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 716540012203 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 716540012204 acyl-activating enzyme (AAE) consensus motif; other site 716540012205 AMP binding site [chemical binding]; other site 716540012206 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 716540012207 Condensation domain; Region: Condensation; pfam00668 716540012208 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 716540012209 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 716540012210 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 716540012211 acyl-activating enzyme (AAE) consensus motif; other site 716540012212 AMP binding site [chemical binding]; other site 716540012213 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 716540012214 Condensation domain; Region: Condensation; pfam00668 716540012215 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 716540012216 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 716540012217 acyl-activating enzyme (AAE) consensus motif; other site 716540012218 AMP binding site [chemical binding]; other site 716540012219 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 716540012220 Condensation domain; Region: Condensation; pfam00668 716540012221 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 716540012222 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 716540012223 acyl-activating enzyme (AAE) consensus motif; other site 716540012224 AMP binding site [chemical binding]; other site 716540012225 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 716540012226 Condensation domain; Region: Condensation; pfam00668 716540012227 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 716540012228 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 716540012229 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 716540012230 acyl-activating enzyme (AAE) consensus motif; other site 716540012231 AMP binding site [chemical binding]; other site 716540012232 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 716540012233 Condensation domain; Region: Condensation; pfam00668 716540012234 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 716540012235 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 716540012236 acyl-activating enzyme (AAE) consensus motif; other site 716540012237 AMP binding site [chemical binding]; other site 716540012238 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 716540012239 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 716540012240 HMMPfam hit to PF00668, Condensation domain, score 1.4e-10 716540012241 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540012242 HMMPfam hit to PF00501, AMP-binding enzyme, score 4e-154 716540012243 PS00455 AMP-binding domain signature. 716540012244 HMMPfam hit to PF00550, Phosphopantetheine attachment site, score 4.9e-16 716540012245 PS00012 Phosphopantetheine attachment site. 716540012246 HMMPfam hit to PF00668, Condensation domain, score 2.5e-92 716540012247 HMMPfam hit to PF00501, AMP-binding enzyme, score 1.7e-170 716540012248 PS00455 AMP-binding domain signature. 716540012249 HMMPfam hit to PF00550, Phosphopantetheine attachment site, score 2.7e-15 716540012250 HMMPfam hit to PF00668, Condensation domain, score 1.9e-32 716540012251 Predicted helix-turn-helix motif with score 1038.000, SD 2.72 at aa 2728-3826, sequence RGLREQARQLGVSLASLCHLAWGQVLAHTSGNQQVVFGTVLLGRLQAGPEADRILGL FVNTLPLRLDIDQRGTREAVQETHAALSRLLGHEHASLALAQRCSGIAAPAPLFSAL LNYRHNDTDVTQPLIDGVDILTMEERTNYPFVLSVEDNDRSLGLTAQSVAAVPPERI CALMQQAMLSLLAALQQSPETPVHHLNILPPQERRQLLLDANVTPAAADTRCLHQHF EQHAARSPHAVALAWDGGTLTYGELNARANRLAHRLLAEGVQPDQLVALCADRSPQL TIGLLAILKAGAAYLPLDPAYAGERLAYILDDARPALLLADEAGRTALGDTGLNTIA LDSTDDDGWPAENPHCAVAPHHLAYVIYTSGSTGQPKGVMVEHRQVDRLFHATAPTF GFSERDTWCLFHSFSFDFSVWEIWGAWCYGGRLVIVPAAVTRSAPDFVRLVCEHGVT VLNQTPSAFRAFARAEADSGLSHQLRWVIFGGEALETASLGEWYQRHAEDAPQLVNM YGITETTVHVTWHLLTRADTELTHSPVGRRVADLRLYLLDEQQQPVPAGASGELYVG GAGVARGYLNRPELSAERFLPDPFSPLPGARMYRAGDLARYLPDGSLAYLGRNDDQV KIRGFRIEPGEIAARLGEHPAVREAAVIARTQHGEPQLVAYVTLHQPCDALAETLRD HLQTRLPAYMIPAAYIALAQLPLTANGKLDRRALPGPDDSAFARSAFEAPQGEVEQA LAAIWQQLLNVERVSRFDNFFALGGHSLLAVRLMERLRRRQLPASVQAVFTTRTLAE LAATLGQQQEVSVPPLLIGRDCRQITPQMLPLISLSQEEIDSLTARLPGGVAAIQDI YGLSPLQEGILFHHLMSDKGDPYLLIAQLRFDDRAALLRYAAALDRVVARHDVLRTA FVWEGLSEPAQLVLRQVDTVLTELELDDNAPALQQLLARFHPRHYRLDLGQAPLLRL IAARDGDGSWYAVQLWHHLIGDHAALAIQQEEIVAFCSGHADSLPPPTPYRNLIAQA RLGVSQQEHEQFFRSMLGDIDTPTLPFGLSDVHANGQGVREAHLALPDALSRGLREQ ARQLGVSLASLCHLAW 716540012252 Predicted helix-turn-helix motif with score 1038.000, SD 2.72 at aa 2728-2749, sequence RGLREQARQLGVSLASLCHLAW 716540012253 HMMPfam hit to PF00501, AMP-binding enzyme, score 2.1e-171 716540012254 PS00455 AMP-binding domain signature. 716540012255 HMMPfam hit to PF00550, Phosphopantetheine attachment site, score 1.1e-14 716540012256 HMMPfam hit to PF00668, Condensation domain, score 1.6e-29 716540012257 Predicted helix-turn-helix motif with score 1269.000, SD 3.51 at aa 3805-5953, sequence RGLREQARQLGVSLASLCHLAWGQVLAHTSGNDKVVFGTVLLGRLQAGPEAERILGL VINTLPLRLDIDQRGTREAVQETHAALSRLLGHEHASLTLAQRCSGIAAPAPLFSAL LNYRHNQESDGSLPMPAGTTLLSGEERTNYPFVMAVDDDGQSLGLSAQMTAGIAPEH ACGWMAQALTSLLAALEKEPQSPVRQLCVVPAAERTLLLETLNQSSQPYPADRCLHD EFEMQAAADPQAIALTCGEQRISYGELNARANQLAHYLMEAGVGPDRRVALCVSRSP SMIVALLAILKAGGAYVPLDPSYPADRLAYIIEDARPVMLLHDAAGREALGEVDIPA LSLDNRLPESWPQDNPQRRQATLTAQHLAYILYTSGSTGKPKGVMLDHAAVQCRLDW MRQTYGFCADDVFLQKTTFNFDLSVWEIFCSLQCGAQLALASDADVKDPQRMADLVT REKVTIAQFVPSTLAPFLATQSPDNASPLRLVIFGGEALTPEHLKQCQSVLPRVAFR NMYGPTEAAIDALFWPCPDNYDGSQIAIGRPMAWTAAYVLDEQGDPVPFGAVGELYL GGAGVARGYLNRAELTAERFLDDPFSPLPGARMYRTGDLARYQNDGSLIYLGRNDDQ VKIRGFRIEPGEIAARLSEHPDVREAAVTAQQRPGAEPRLVAYVVPLRTDNAPAAAA LRTFLAGRLPDYMLPAAWLTLDALPLTPNGKLDRRALPVPDDDAFARADFEAPQGDT EQLLANLWSELLGVSRIGRRDDFFALGGHSLLAVRLSGRLRQLHHGALTVQQIFTHP LLAEMAAAVSAAPRDALPAFIRADRDRPLPLSFAQQRLWFLWQLEEDPATYNMPAAV TLHGNLDAGALHLALGDLFARHEAWRMTFSEQDGQPFARLLPPDAAPPLVHHDLRDH ANHQAQLQRLCAEEAHQPFSLSRGPLVRARLVRLPDDRCCLLVTQHHIVSDGWSVGV MWRELSACYNARRAGSTAVLPPLPLQFPDYAAWQRRFLTPERLSQQADYWYQQLHGA PDLLPLPTDRPRPPQQSYLGAAAPVDFGAEFSAALRRFSRRHGVTPYMTVLAAWSVV LGRLAGCDDLVIGTPVAGRDRAELEPMVGFLVNTLALRIRPQHDTSVADLLARVRQQ VLDGQANQELPFEQVVERLNPPRQLAHAPLFQVLLAWQTAPAQPELDGLQVSPAPDA YARIKFDLELSLVDDAHGIHGALRYATALFDAATAQRHAGYLLNVLQAMLAEPQLPL ARLPVLGEEERRRLLLTSNLTPAGRDTRCLHQHFEQHAARRPHAVALAWDGGTLTYG ELNARANRLAHRLLAEGVQPDQLAAICASRSPQMICAILAVLKAGAAWLPLDPDYPA DRLAYILDDARPALLLADRAGRTALGDTGLNTIALDSTGDNNGWPAENPHCAVAPQH LAYVIYTSGSTGRPKGVMIEHQHLTHLCFAQQRLLAVDSHSRVLQFASISFDASVSE LAMAFSQGARLTLVGEEVRRDAAMLMQFIQQQGITHATLPPALFRGVDPAPLADAEC LVFAGEAPGAALLNTLGPRTRVLNAYGPTEAAVCTTAWVADRPCEEGYIPIGLPIPN SCIYLLDDNLQPVPTGATGEIYIGGLGVARGYLNQPALTGERFLTDPFSPQPGARMY RSGDLARYLPDGNLAYLGRNDDQVKIRGFRIEPGEIAACLGEHPEVREAAVIARTQH GEPQLLAYVVTQLPLEDLASVLRTFLADRLPAYMIPAAYIALAQLPLTANGKLDRRA LPEPDDSAFARSAFAAPQGEVEQALAAIWQQLLNVERVSRFDNFFALGGHSLLAVQL MEQLRRRQLSASVQALFTTRTLADLAASLGQQQEISVPPLLLTQDCRQVTPEMLPLI SLRQAEIDRLTARLPGGIAAIKDIYGLSPLQEGILFHHLLAGGGDPYLLLVQLRFDS HAALLRYAAALDQVVARHDVLRTAFVWEGLSEPAQVVLREVDSVLTVLELDDNAPAM TQLLSRYDLAHFRLDLGQPPLLRLIAARGDDGRWYALQMWHHLVGDHSTLAIQQQEI AAIYAGQGDSLPPPTPYRNLIAQARLGVSQQEHEQFFRNMLGDIDTPTLPFGLTGEH CDASPVTEAHQRLPAELNRRLRDVARRLGVSLASLCHLAW 716540012258 Predicted helix-turn-helix motif with score 1269.000, SD 3.51 at aa 3805-3826, sequence RGLREQARQLGVSLASLCHLAW 716540012259 HMMPfam hit to PF00501, AMP-binding enzyme, score 9.5e-173 716540012260 PS00455 AMP-binding domain signature. 716540012261 HMMPfam hit to PF00550, Phosphopantetheine attachment site, score 4.9e-16 716540012262 PS00012 Phosphopantetheine attachment site. 716540012263 HMMPfam hit to PF00668, Condensation domain, score 2.5e-92 716540012264 HMMPfam hit to PF00501, AMP-binding enzyme, score 2.2e-164 716540012265 PS00455 AMP-binding domain signature. 716540012266 HMMPfam hit to PF00550, Phosphopantetheine attachment site, score 4.6e-16 716540012267 HMMPfam hit to PF00668, Condensation domain, score 1.1e-29 716540012268 Predicted helix-turn-helix motif with score 1269.000, SD 3.51 at aa 5932-5953, sequence RRLRDVARRLGVSLASLCHLAW 716540012269 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 716540012270 HMMPfam hit to PF00501, AMP-binding enzyme, score 3.4e-167 716540012271 PS00455 AMP-binding domain signature. 716540012272 HMMPfam hit to PF00550, Phosphopantetheine attachment site, score 2.3e-10 716540012273 PS00012 Phosphopantetheine attachment site. 716540012274 HMMPfam hit to PF00975, Thioesterase domain, score 1.5e-16 716540012275 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 716540012276 PAAR motif; Region: PAAR_motif; pfam05488 716540012277 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 716540012278 RHS Repeat; Region: RHS_repeat; cl11982 716540012279 RHS Repeat; Region: RHS_repeat; pfam05593 716540012280 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 716540012281 RHS Repeat; Region: RHS_repeat; pfam05593 716540012282 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 716540012283 RHS Repeat; Region: RHS_repeat; cl11982 716540012284 RHS protein; Region: RHS; pfam03527 716540012285 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 716540012286 2 transmembrane helices predicted for EAM_2423 by TMHMM2.0 at aa 15-37 and 42-64 716540012287 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540012288 HMMPfam hit to PF05488, PAAR motif, score 6.7e-05 716540012289 HMMPfam hit to PF05488, PAAR motif, score 5e-08 716540012290 HMMPfam hit to PF05593, RHS Repeat, score 0.0071 716540012291 HMMPfam hit to PF05593, RHS Repeat, score 3.7e-05 716540012292 HMMPfam hit to PF05593, RHS Repeat, score 1.6e-05 716540012293 HMMPfam hit to PF05593, RHS Repeat, score 1.9e-08 716540012294 HMMPfam hit to PF05593, RHS Repeat, score 0.33 716540012295 HMMPfam hit to PF05593, RHS Repeat, score 6.5e-07 716540012296 HMMPfam hit to PF05593, RHS Repeat, score 0.0025 716540012297 HMMPfam hit to PF05593, RHS Repeat, score 0.014 716540012298 HMMPfam hit to PF05593, RHS Repeat, score 0.023 716540012299 HMMPfam hit to PF05593, RHS Repeat, score 0.027 716540012300 HMMPfam hit to PF05593, RHS Repeat, score 0.028 716540012301 HMMPfam hit to PF05593, RHS Repeat, score 0.29 716540012302 HMMPfam hit to PF05593, RHS Repeat, score 0.98 716540012303 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 716540012304 RHS protein; Region: RHS; pfam03527 716540012305 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 716540012306 HMMPfam hit to PF05593, RHS Repeat, score 0.027 716540012307 HMMPfam hit to PF05593, RHS Repeat, score 0.12 716540012308 HMMPfam hit to PF05593, RHS Repeat, score 0.29 716540012309 HMMPfam hit to PF05593, RHS Repeat, score 0.98 716540012310 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 716540012311 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 716540012312 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 716540012313 Helicase; Region: Helicase_RecD; pfam05127 716540012314 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 716540012315 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 716540012316 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1.5e-05 716540012317 HMMPfam hit to PF05127, ATPase (DUF699), score 7.8e-50 716540012318 PS00017 ATP/GTP-binding site motif A (P-loop). 716540012319 Predicted metalloprotease [General function prediction only]; Region: COG2321 716540012320 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 716540012321 HMMPfam hit to PF04228, neutral zinc metallopeptidase, score 2.1e-191 716540012322 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 716540012323 1 transmembrane helix predicted for EAM_2429 by TMHMM2.0 at aa 36-58 716540012324 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 716540012325 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 716540012326 ATP binding site [chemical binding]; other site 716540012327 active site 716540012328 substrate binding site [chemical binding]; other site 716540012329 HMMPfam hit to PF01259, SAICAR synthetase, score 6.3e-110 716540012330 PS01058 SAICAR synthetase signature 2. 716540012331 PS01057 SAICAR synthetase signature 1. 716540012332 lipoprotein; Provisional; Region: PRK11679 716540012333 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 716540012334 HMMPfam hit to PF06804, NlpB/DapX lipoprotein, score 3.2e-161 716540012335 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540012336 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 716540012337 dihydrodipicolinate synthase; Region: dapA; TIGR00674 716540012338 dimer interface [polypeptide binding]; other site 716540012339 active site 716540012340 catalytic residue [active] 716540012341 HMMPfam hit to PF00701, Dihydrodipicolinate synthetase family, score 2.1e-152 716540012342 PS00666 Dihydrodipicolinate synthetase signature 2. 716540012343 PS00665 Dihydrodipicolinate synthetase signature 1. 716540012344 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 716540012345 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 716540012346 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 716540012347 HMMPfam hit to PF01842, ACT domain, score 0.011 716540012348 HMMPfam hit to PF01842, ACT domain, score 0.089 716540012349 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 716540012350 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 716540012351 catalytic triad [active] 716540012352 HMMPfam hit to PF02630, SCO1/SenC, score 0.00082 716540012353 HMMPfam hit to PF08534, Redoxin, score 7.6e-21 716540012354 HMMPfam hit to PF00578, AhpC/TSA family, score 1.2e-09 716540012355 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 716540012356 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 716540012357 metal binding site [ion binding]; metal-binding site 716540012358 active site 716540012359 I-site; other site 716540012360 HMMPfam hit to PF00990, GGDEF domain, score 2.7e-60 716540012361 1 transmembrane helix predicted for EAM_2435 by TMHMM2.0 at aa 12-34 716540012362 Signal peptide predicted for EAM_2435 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.650 between residues 31 and 32 716540012363 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 716540012364 Peptidase family M48; Region: Peptidase_M48; pfam01435 716540012365 Signal peptide predicted for EAM_2436 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.982 between residues 27 and 28 716540012366 HMMPfam hit to PF01435, Peptidase family M48, score 2.1e-32 716540012367 PS00761 Signal peptidases I signature 3. 716540012368 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 716540012369 DNA replication initiation factor; Provisional; Region: PRK08084 716540012370 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 716540012371 HMMPfam hit to PF00308, Bacterial dnaA protein, score 2.2e-07 716540012372 uracil transporter; Provisional; Region: PRK10720 716540012373 12 transmembrane helices predicted for EAM_2439 by TMHMM2.0 at aa 20-39, 44-61, 68-85, 89-108, 120-142, 157-179, 184-206, 226-248, 303-325, 330-352, 364-386 and 391-410 716540012374 HMMPfam hit to PF00860, Permease family, score 1.6e-138 716540012375 PS01116 Xanthine/uracil permeases family signature. 716540012376 PS00017 ATP/GTP-binding site motif A (P-loop). 716540012377 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 716540012378 active site 716540012379 HMMPfam hit to PF00156, Phosphoribosyl transferase domain, score 3.2e-14 716540012380 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 716540012381 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 716540012382 dimerization interface [polypeptide binding]; other site 716540012383 putative ATP binding site [chemical binding]; other site 716540012384 HMMPfam hit to PF00586, AIR synthase related protein, N-terminal dom, score 6.9e-74 716540012385 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal dom, score 1.5e-51 716540012386 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 716540012387 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 716540012388 active site 716540012389 substrate binding site [chemical binding]; other site 716540012390 cosubstrate binding site; other site 716540012391 catalytic site [active] 716540012392 HMMPfam hit to PF00551, Formyl transferase, score 1.2e-82 716540012393 PS00373 Phosphoribosylglycinamide formyltransferase active site. 716540012394 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 716540012395 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 716540012396 Walker A/P-loop; other site 716540012397 ATP binding site [chemical binding]; other site 716540012398 Q-loop/lid; other site 716540012399 ABC transporter signature motif; other site 716540012400 Walker B; other site 716540012401 D-loop; other site 716540012402 H-loop/switch region; other site 716540012403 HMMPfam hit to PF00005, ABC transporter, score 1.7e-55 716540012404 PS00211 ABC transporters family signature. 716540012405 PS00017 ATP/GTP-binding site motif A (P-loop). 716540012406 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 716540012407 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 716540012408 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540012409 dimer interface [polypeptide binding]; other site 716540012410 conserved gate region; other site 716540012411 putative PBP binding loops; other site 716540012412 ABC-ATPase subunit interface; other site 716540012413 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 5.2e-14 716540012414 6 transmembrane helices predicted for EAM_2444 by TMHMM2.0 at aa 13-35, 304-326, 346-368, 383-405, 433-455 and 514-536 716540012415 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 716540012416 Signal peptide predicted for EAM_2444 by SignalP 2.0 HMM (Signal peptide probability 0.948) with cleavage site probability 0.439 between residues 34 and 35 716540012417 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 716540012418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540012419 conserved gate region; other site 716540012420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540012421 ABC-ATPase subunit interface; other site 716540012422 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 2.1e-05 716540012423 8 transmembrane helices predicted for EAM_2445 by TMHMM2.0 at aa 31-53, 421-443, 456-475, 485-502, 522-544, 564-583, 613-635 and 681-703 716540012424 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 716540012425 polyphosphate kinase; Provisional; Region: PRK05443 716540012426 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 716540012427 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 716540012428 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 716540012429 putative active site [active] 716540012430 catalytic site [active] 716540012431 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 716540012432 domain interface [polypeptide binding]; other site 716540012433 active site 716540012434 catalytic site [active] 716540012435 HMMPfam hit to PF02503, Polyphosphate kinase, score 0 716540012436 exopolyphosphatase; Provisional; Region: PRK10854 716540012437 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 716540012438 nucleotide binding site [chemical binding]; other site 716540012439 HMMPfam hit to PF02541, Ppx/GppA phosphatase family, score 4.9e-135 716540012440 tellurite resistance protein TehB; Provisional; Region: PRK11207 716540012441 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716540012442 S-adenosylmethionine binding site [chemical binding]; other site 716540012443 HMMPfam hit to PF03848, Tellurite resistance protein TehB, score 1e-69 716540012444 HMMPfam hit to PF08241, Methyltransferase domain, score 1e-05 716540012445 MASE1; Region: MASE1; cl17823 716540012446 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 716540012447 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 716540012448 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 716540012449 HMMPfam hit to PF00563, EAL domain, score 7e-69 716540012450 HMMPfam hit to PF05231, MASE1, score 9e-17 716540012451 8 transmembrane helices predicted for EAM_2449 by TMHMM2.0 at aa 15-34, 41-60, 80-102, 126-148, 168-190, 211-233, 258-280 and 293-315 716540012452 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 716540012453 Signal peptide predicted for EAM_2449 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.916 between residues 31 and 32 716540012454 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 716540012455 MgtE intracellular N domain; Region: MgtE_N; smart00924 716540012456 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 716540012457 HMMPfam hit to PF03448, MgtE intracellular domain, score 2.2e-26 716540012458 HMMPfam hit to PF00571, CBS domain pair, score 1e-11 716540012459 5 transmembrane helices predicted for EAM_2450 by TMHMM2.0 at aa 314-333, 338-360, 388-410, 420-442 and 455-477 716540012460 HMMPfam hit to PF01769, Divalent cation transporter, score 2.5e-16 716540012461 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540012462 D-galactonate transporter; Region: 2A0114; TIGR00893 716540012463 putative substrate translocation pore; other site 716540012464 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 7.2e-59 716540012465 11 transmembrane helices predicted for EAM_2451 by TMHMM2.0 at aa 63-82, 95-117, 122-144, 156-178, 188-210, 257-279, 289-311, 324-341, 345-367, 374-396 and 411-433 716540012466 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 716540012467 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 716540012468 putative NAD(P) binding site [chemical binding]; other site 716540012469 active site 716540012470 putative substrate binding site [chemical binding]; other site 716540012471 HMMPfam hit to PF04321, RmlD substrate binding domain, score 0.0002 716540012472 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase fam, score 2.3e-08 716540012473 HMMPfam hit to PF01073, 3-beta hydroxysteroid dehydrogenase/iso, score 3.8e-05 716540012474 HMMPfam hit to PF07993, Male sterility protein, score 7.4e-08 716540012475 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 716540012476 DNA-binding site [nucleotide binding]; DNA binding site 716540012477 RNA-binding motif; other site 716540012478 HMMPfam hit to PF00313, 'Cold-shock' DNA-binding domain, score 2.1e-05 716540012479 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 716540012480 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 716540012481 active site 716540012482 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 1.7e-42 716540012483 PS01129 Rlu family of pseudouridine synthase signature. 716540012484 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 716540012485 HTH-like domain; Region: HTH_21; pfam13276 716540012486 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 716540012487 Integrase core domain; Region: rve; pfam00665 716540012488 Integrase core domain; Region: rve_3; pfam13683 716540012489 HMMPfam hit to PF00665, Integrase core domain, score 7.4e-30 716540012490 HMMPfam hit to PF01527, Transposase, score 6.5e-19 716540012491 Predicted helix-turn-helix motif with score 1649.000, SD 4.80 at aa 22-43, sequence RTVKDVCREAGISEATDYNWKS 716540012492 1 transmembrane helix predicted for EAM_2459 by TMHMM2.0 at aa 15-34 716540012493 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 716540012494 Integrase core domain; Region: rve_3; pfam13683 716540012495 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 716540012496 GMP synthase; Reviewed; Region: guaA; PRK00074 716540012497 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 716540012498 AMP/PPi binding site [chemical binding]; other site 716540012499 candidate oxyanion hole; other site 716540012500 catalytic triad [active] 716540012501 potential glutamine specificity residues [chemical binding]; other site 716540012502 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 716540012503 ATP Binding subdomain [chemical binding]; other site 716540012504 Ligand Binding sites [chemical binding]; other site 716540012505 Dimerization subdomain; other site 716540012506 HMMPfam hit to PF00958, GMP synthase C terminal domain, score 4.4e-59 716540012507 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 4.5e-51 716540012508 PS00442 Glutamine amidotransferases class-I active site. 716540012509 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 716540012510 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 716540012511 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 716540012512 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 716540012513 active site 716540012514 HMMPfam hit to PF00478, IMP dehydrogenase / GMP reductase domain, score 3.7e-242 716540012515 PS00487 IMP dehydrogenase / GMP reductase signature. 716540012516 HMMPfam hit to PF00571, CBS domain pair, score 8.3e-24 716540012517 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 716540012518 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 716540012519 generic binding surface II; other site 716540012520 generic binding surface I; other site 716540012521 HMMPfam hit to PF01336, OB-fold nucleic acid binding domain, score 7.6e-13 716540012522 HMMPfam hit to PF02601, Exonuclease VII, large subunit, score 5.7e-74 716540012523 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 716540012524 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 716540012525 active site 716540012526 Zn binding site [ion binding]; other site 716540012527 HMMPfam hit to PF01447, Thermolysin metallopeptidase, catalyti, score 1.7e-25 716540012528 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 716540012529 HMMPfam hit to PF02868, Thermolysin metallopeptidase, alpha-he, score 1.6e-27 716540012530 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 716540012531 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 716540012532 Trp docking motif [polypeptide binding]; other site 716540012533 putative active site [active] 716540012534 HMMPfam hit to PF01011, PQQ enzyme repeat, score 1.2e-08 716540012535 HMMPfam hit to PF01011, PQQ enzyme repeat, score 7.8e-06 716540012536 5 transmembrane helices predicted for EAM_2469 by TMHMM2.0 at aa 12-34, 39-61, 66-83, 93-115 and 127-146 716540012537 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 716540012538 GTP-binding protein Der; Reviewed; Region: PRK00093 716540012539 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 716540012540 G1 box; other site 716540012541 GTP/Mg2+ binding site [chemical binding]; other site 716540012542 Switch I region; other site 716540012543 G2 box; other site 716540012544 Switch II region; other site 716540012545 G3 box; other site 716540012546 G4 box; other site 716540012547 G5 box; other site 716540012548 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 716540012549 G1 box; other site 716540012550 GTP/Mg2+ binding site [chemical binding]; other site 716540012551 Switch I region; other site 716540012552 G2 box; other site 716540012553 G3 box; other site 716540012554 Switch II region; other site 716540012555 G4 box; other site 716540012556 G5 box; other site 716540012557 HMMPfam hit to PF01926, GTPase of unknown function, score 9.5e-44 716540012558 PS00017 ATP/GTP-binding site motif A (P-loop). 716540012559 HMMPfam hit to PF01926, GTPase of unknown function, score 6.8e-47 716540012560 PS00017 ATP/GTP-binding site motif A (P-loop). 716540012561 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 716540012562 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 716540012563 Trp docking motif [polypeptide binding]; other site 716540012564 HMMPfam hit to PF01011, PQQ enzyme repeat, score 2.2e-05 716540012565 HMMPfam hit to PF01011, PQQ enzyme repeat, score 5.6e-07 716540012566 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540012567 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 716540012568 1 transmembrane helix predicted for EAM_2473 by TMHMM2.0 at aa 21-43 716540012569 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 716540012570 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 716540012571 dimer interface [polypeptide binding]; other site 716540012572 motif 1; other site 716540012573 active site 716540012574 motif 2; other site 716540012575 motif 3; other site 716540012576 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 716540012577 anticodon binding site; other site 716540012578 HMMPfam hit to PF03129, Anticodon binding domain, score 1.6e-17 716540012579 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 716540012580 HMMPfam hit to PF00587, tRNA synthetase class II core domain (, score 1.9e-55 716540012581 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 716540012582 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 716540012583 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 716540012584 HMMPfam hit to PF04551, GcpE protein, score 3.9e-244 716540012585 cytoskeletal protein RodZ; Provisional; Region: PRK10856 716540012586 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 716540012587 non-specific DNA binding site [nucleotide binding]; other site 716540012588 salt bridge; other site 716540012589 sequence-specific DNA binding site [nucleotide binding]; other site 716540012590 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 716540012591 1 transmembrane helix predicted for EAM_2476 by TMHMM2.0 at aa 111-133 716540012592 Predicted helix-turn-helix motif with score 1514.000, SD 4.34 at aa 28-49, sequence LTQQNVAERLCLKLSTIRDIEE 716540012593 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 716540012594 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 716540012595 binding surface 716540012596 TPR motif; other site 716540012597 HMMPfam hit to PF00515, Tetratricopeptide repeat, score 0.34 716540012598 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 0.0029 716540012599 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 0.00017 716540012600 Signal peptide predicted for EAM_2477 by SignalP 2.0 HMM (Signal peptide probability 0.960) with cleavage site probability 0.573 between residues 25 and 26 716540012601 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540012602 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 716540012603 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 716540012604 FeS/SAM binding site; other site 716540012605 HMMPfam hit to PF04055, Radical SAM superfamily, score 1.8e-15 716540012606 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 716540012607 active site 716540012608 multimer interface [polypeptide binding]; other site 716540012609 HMMPfam hit to PF00334, Nucleoside diphosphate kinase, score 4.1e-93 716540012610 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 716540012611 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 716540012612 active site residue [active] 716540012613 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 716540012614 active site residue [active] 716540012615 HMMPfam hit to PF00581, Rhodanese-like domain, score 2.4e-28 716540012616 PS00380 Rhodanese signature 1. 716540012617 HMMPfam hit to PF00581, Rhodanese-like domain, score 1.5e-20 716540012618 PS00683 Rhodanese C-terminal signature. 716540012619 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 716540012620 HMMPfam hit to PF02615, Malate/L-lactate dehydrogenase, score 8.8e-39 716540012621 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 716540012622 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 716540012623 dimer interface [polypeptide binding]; other site 716540012624 NADP binding site [chemical binding]; other site 716540012625 catalytic residues [active] 716540012626 HMMPfam hit to PF00171, Aldehyde dehydrogenase family, score 5.8e-15 716540012627 PS00070 Aldehyde dehydrogenases cysteine active site. 716540012628 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 716540012629 HMMPfam hit to PF04324, BFD-like [2Fe-2S] binding domain, score 1.4e-07 716540012630 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidoreduc, score 8e-17 716540012631 HMMPfam hit to PF03486, HI0933-like protein, score 0.0011 716540012632 Signal peptide predicted for EAM_2483 by SignalP 2.0 HMM (Signal peptide probability 0.987) with cleavage site probability 0.443 between residues 28 and 29 716540012633 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 716540012634 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 716540012635 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 716540012636 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 4.6e-67 716540012637 1 transmembrane helix predicted for EAM_2485 by TMHMM2.0 at aa 7-29 716540012638 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540012639 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 716540012640 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 716540012641 HMMPfam hit to PF05544, Proline racemase, score 1e-113 716540012642 Transcriptional regulators [Transcription]; Region: GntR; COG1802 716540012643 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 716540012644 DNA-binding site [nucleotide binding]; DNA binding site 716540012645 FCD domain; Region: FCD; pfam07729 716540012646 HMMPfam hit to PF07729, FCD domain, score 5e-08 716540012647 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR fa, score 1e-16 716540012648 HMMPfam hit to PF01325, Iron dependent repressor, N-terminal D, score 0.00089 716540012649 Predicted helix-turn-helix motif with score 1003.000, SD 2.60 at aa 38-59, sequence VRQDEITKKFNVSKIPVREALK 716540012650 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 716540012651 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 716540012652 inhibitor site; inhibition site 716540012653 active site 716540012654 dimer interface [polypeptide binding]; other site 716540012655 catalytic residue [active] 716540012656 HMMPfam hit to PF00701, Dihydrodipicolinate synthetase family, score 5.6e-44 716540012657 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 716540012658 14 transmembrane helices predicted for EAM_2489 by TMHMM2.0 at aa 9-31, 41-63, 84-106, 128-150, 157-179, 199-221, 234-256, 285-307, 340-357, 362-384, 397-419, 423-445, 457-479 and 489-508 716540012659 HMMPfam hit to PF00324, Amino acid permease, score 1.3e-06 716540012660 Signal peptide predicted for EAM_2489 by SignalP 2.0 HMM (Signal peptide probability 0.928) with cleavage site probability 0.540 between residues 38 and 39 716540012661 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 716540012662 HMMPfam hit to PF07179, SseB protein, score 2.6e-141 716540012663 aminopeptidase B; Provisional; Region: PRK05015 716540012664 Peptidase; Region: DUF3663; pfam12404 716540012665 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 716540012666 interface (dimer of trimers) [polypeptide binding]; other site 716540012667 Substrate-binding/catalytic site; other site 716540012668 Zn-binding sites [ion binding]; other site 716540012669 HMMPfam hit to PF00883, Cytosol aminopeptidase family, catalyti, score 3.2e-161 716540012670 PS00631 Cytosol aminopeptidase signature. 716540012671 cysteine desulfurase; Provisional; Region: PRK14012 716540012672 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 716540012673 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 716540012674 catalytic residue [active] 716540012675 HMMPfam hit to PF00266, Aminotransferase class-V, score 7.4e-117 716540012676 HMMPfam hit to PF01212, Beta-eliminating lyase, score 1.1e-05 716540012677 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 716540012678 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 716540012679 Rrf2 family protein; Region: rrf2_super; TIGR00738 716540012680 HMMPfam hit to PF02082, Transcriptional regulator, score 5.3e-51 716540012681 PS01332 Uncharacterized protein family UPF0074 signature. 716540012682 Predicted helix-turn-helix motif with score 1222.000, SD 3.35 at aa 26-47, sequence VPLADISERQGISLSYLEQLFS 716540012683 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 716540012684 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 716540012685 HMMPfam hit to PF00588, SpoU rRNA Methylase family, score 1.7e-35 716540012686 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 716540012687 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 716540012688 active site 716540012689 dimerization interface [polypeptide binding]; other site 716540012690 HMMPfam hit to PF00459, Inositol monophosphatase family, score 9.3e-111 716540012691 PS00629 Inositol monophosphatase family signature 1. 716540012692 PS00630 Inositol monophosphatase family signature 2. 716540012693 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 716540012694 PRD domain; Region: PRD; pfam00874 716540012695 HMMPfam hit to PF00874, PRD domain, score 4e-10 716540012696 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 716540012697 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 716540012698 dimer interface [polypeptide binding]; other site 716540012699 active site 716540012700 glycine-pyridoxal phosphate binding site [chemical binding]; other site 716540012701 folate binding site [chemical binding]; other site 716540012702 HMMPfam hit to PF01276, Orn/Lys/Arg decarboxylase, major doma, score 0.0082 716540012703 HMMPfam hit to PF00464, Serine hydroxymethyltransferase, score 4.2e-282 716540012704 HMMPfam hit to PF00155, Aminotransferase class I and II, score 9.1e-05 716540012705 HMMPfam hit to PF01212, Beta-eliminating lyase, score 0.001 716540012706 PS00096 Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. 716540012707 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 716540012708 Nitrogen regulatory protein P-II; Region: P-II; smart00938 716540012709 HMMPfam hit to PF00543, Nitrogen regulatory protein P-II, score 4.9e-69 716540012710 PS00638 P-II protein C-terminal region signature. 716540012711 PS00496 P-II protein urydylation site. 716540012712 response regulator GlrR; Provisional; Region: PRK15115 716540012713 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716540012714 active site 716540012715 phosphorylation site [posttranslational modification] 716540012716 intermolecular recognition site; other site 716540012717 dimerization interface [polypeptide binding]; other site 716540012718 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716540012719 Walker A motif; other site 716540012720 ATP binding site [chemical binding]; other site 716540012721 Walker B motif; other site 716540012722 arginine finger; other site 716540012723 PS00688 Sigma-54 interaction domain C-terminal part signature. 716540012724 HMMPfam hit to PF00158, Sigma-54 interaction domain, score 2.6e-145 716540012725 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 716540012726 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 716540012727 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.7e-39 716540012728 hypothetical protein; Provisional; Region: PRK10722 716540012729 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540012730 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 716540012731 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 716540012732 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 716540012733 dimer interface [polypeptide binding]; other site 716540012734 phosphorylation site [posttranslational modification] 716540012735 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716540012736 ATP binding site [chemical binding]; other site 716540012737 Mg2+ binding site [ion binding]; other site 716540012738 G-X-G motif; other site 716540012739 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 1.4e-24 716540012740 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 2.5e-19 716540012741 HMMPfam hit to PF00672, HAMP domain, score 1.2e-10 716540012742 2 transmembrane helices predicted for EAM_2501 by TMHMM2.0 at aa 15-34 and 175-197 716540012743 Signal peptide predicted for EAM_2501 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.671 between residues 30 and 31 716540012744 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 716540012745 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 716540012746 dimerization interface [polypeptide binding]; other site 716540012747 ATP binding site [chemical binding]; other site 716540012748 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 716540012749 dimerization interface [polypeptide binding]; other site 716540012750 ATP binding site [chemical binding]; other site 716540012751 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 716540012752 putative active site [active] 716540012753 catalytic triad [active] 716540012754 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal dom, score 8.2e-23 716540012755 PS00213 Lipocalin signature. 716540012756 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal dom, score 8.6e-34 716540012757 HMMPfam hit to PF00586, AIR synthase related protein, N-terminal dom, score 1.1e-45 716540012758 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 716540012759 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 716540012760 substrate binding pocket [chemical binding]; other site 716540012761 membrane-bound complex binding site; other site 716540012762 hinge residues; other site 716540012763 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 716540012764 N-acetyl-D-glucosamine binding site [chemical binding]; other site 716540012765 catalytic residue [active] 716540012766 Signal peptide predicted for EAM_2503 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.949 between residues 21 and 22 716540012767 1 transmembrane helix predicted for EAM_2503 by TMHMM2.0 at aa 7-29 716540012768 HMMPfam hit to PF00497, Bacterial extracellular solute-binding prot, score 1.2e-12 716540012769 HMMPfam hit to PF01464, Transglycosylase SLT domain, score 2.7e-38 716540012770 PS00922 Prokaryotic transglycosylases signature. 716540012771 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 716540012772 nucleoside/Zn binding site; other site 716540012773 dimer interface [polypeptide binding]; other site 716540012774 catalytic motif [active] 716540012775 HMMPfam hit to PF00383, Cytidine and deoxycytidylate deaminas, score 4.5e-46 716540012776 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 716540012777 hypothetical protein; Provisional; Region: PRK11590 716540012778 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 716540012779 1 transmembrane helix predicted for EAM_2505 by TMHMM2.0 at aa 33-55 716540012780 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 716540012781 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 716540012782 putative active site [active] 716540012783 HMMPfam hit to PF01380, SIS domain, score 0.031 716540012784 PS01272 Glucokinase regulatory protein family signature. 716540012785 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 716540012786 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 716540012787 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 716540012788 putative active site [active] 716540012789 HMMPfam hit to PF01418, Helix-turn-helix domain, rpiR family, score 5.6e-41 716540012790 Predicted helix-turn-helix motif with score 1205.000, SD 3.29 at aa 35-56, sequence LSSQKLADESGVSQSSVVKFAQ 716540012791 HMMPfam hit to PF01380, SIS domain, score 5.9e-31 716540012792 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 716540012793 HMMPfam hit to PF01648, 4'-phosphopantetheinyl transferase superfami, score 2.3e-22 716540012794 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 716540012795 active site 716540012796 hydrophilic channel; other site 716540012797 dimerization interface [polypeptide binding]; other site 716540012798 catalytic residues [active] 716540012799 active site lid [active] 716540012800 HMMPfam hit to PF03740, Pyridoxal phosphate biosynthesis protein Pdx, score 1.7e-138 716540012801 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 716540012802 Recombination protein O N terminal; Region: RecO_N; pfam11967 716540012803 Recombination protein O C terminal; Region: RecO_C; pfam02565 716540012804 HMMPfam hit to PF02565, Recombination protein O, score 2.9e-101 716540012805 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 716540012806 GTPase Era; Reviewed; Region: era; PRK00089 716540012807 G1 box; other site 716540012808 GTP/Mg2+ binding site [chemical binding]; other site 716540012809 Switch I region; other site 716540012810 G2 box; other site 716540012811 Switch II region; other site 716540012812 G3 box; other site 716540012813 G4 box; other site 716540012814 G5 box; other site 716540012815 KH domain; Region: KH_2; pfam07650 716540012816 HMMPfam hit to PF07650, KH domain, score 8.4e-27 716540012817 HMMPfam hit to PF01926, GTPase of unknown function, score 2.7e-39 716540012818 PS00017 ATP/GTP-binding site motif A (P-loop). 716540012819 ribonuclease III; Reviewed; Region: rnc; PRK00102 716540012820 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 716540012821 dimerization interface [polypeptide binding]; other site 716540012822 active site 716540012823 metal binding site [ion binding]; metal-binding site 716540012824 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 716540012825 dsRNA binding site [nucleotide binding]; other site 716540012826 HMMPfam hit to PF00035, Double-stranded RNA binding motif, score 1.5e-14 716540012827 HMMPfam hit to PF00636, RNase3 domain, score 1.5e-47 716540012828 PS00517 Ribonuclease III family signature. 716540012829 signal peptidase I; Provisional; Region: PRK10861 716540012830 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 716540012831 Catalytic site [active] 716540012832 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 716540012833 PS00761 Signal peptidases I signature 3. 716540012834 HMMPfam hit to PF00717, Peptidase S24-like, score 1.3e-24 716540012835 PS00760 Signal peptidases I lysine active site. 716540012836 PS00501 Signal peptidases I serine active site. 716540012837 2 transmembrane helices predicted for EAM_2515 by TMHMM2.0 at aa 5-22 and 54-76 716540012838 Signal peptide predicted for EAM_2515 by SignalP 2.0 HMM (Signal peptide probability 0.805) with cleavage site probability 0.724 between residues 21 and 22 716540012839 GTP-binding protein LepA; Provisional; Region: PRK05433 716540012840 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 716540012841 G1 box; other site 716540012842 putative GEF interaction site [polypeptide binding]; other site 716540012843 GTP/Mg2+ binding site [chemical binding]; other site 716540012844 Switch I region; other site 716540012845 G2 box; other site 716540012846 G3 box; other site 716540012847 Switch II region; other site 716540012848 G4 box; other site 716540012849 G5 box; other site 716540012850 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 716540012851 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 716540012852 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 716540012853 HMMPfam hit to PF06421, GTP-binding protein LepA C-terminus, score 5.2e-79 716540012854 HMMPfam hit to PF00679, Elongation factor G C-terminus, score 8.3e-34 716540012855 HMMPfam hit to PF03144, Elongation factor Tu domain, score 1.7e-06 716540012856 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 1.8e-74 716540012857 PS00301 GTP-binding elongation factors signature. 716540012858 PS00017 ATP/GTP-binding site motif A (P-loop). 716540012859 Signal peptide predicted for EAM_2517 by SignalP 2.0 HMM (Signal peptide probability 0.933) with cleavage site probability 0.655 between residues 23 and 24 716540012860 Antitermination protein; Region: Antiterm; pfam03589 716540012861 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 716540012862 HMMPfam hit to PF03589, Antitermination protein, score 2.8e-09 716540012863 PS00190 Cytochrome c family heme-binding site signature. 716540012864 SoxR reducing system protein RseC; Provisional; Region: PRK10862 716540012865 HMMPfam hit to PF04246, Positive regulator of sigma(E), RseC/MucC, score 8.6e-45 716540012866 2 transmembrane helices predicted for EAM_2519 by TMHMM2.0 at aa 74-96 and 106-128 716540012867 anti-sigma E factor; Provisional; Region: rseB; PRK09455 716540012868 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 716540012869 HMMPfam hit to PF03888, MucB/RseB family, score 5.3e-169 716540012870 1 transmembrane helix predicted for EAM_2520 by TMHMM2.0 at aa 5-27 716540012871 Signal peptide predicted for EAM_2520 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.791 between residues 23 and 24 716540012872 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 716540012873 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 716540012874 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 716540012875 HMMPfam hit to PF03873, Anti sigma-E protein RseA, C-terminal domain, score 1.3e-15 716540012876 1 transmembrane helix predicted for EAM_2521 by TMHMM2.0 at aa 96-118 716540012877 HMMPfam hit to PF03872, Anti sigma-E protein RseA, N-terminal domain, score 1.3e-39 716540012878 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 716540012879 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 716540012880 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 716540012881 DNA binding residues [nucleotide binding] 716540012882 HMMPfam hit to PF04545, Sigma-70, region, score 1.7e-14 716540012883 HMMPfam hit to PF08281, Sigma-70, region, score 4.4e-19 716540012884 Predicted helix-turn-helix motif with score 987.000, SD 2.55 at aa 154-175, sequence LSYEDIAVIMDCPVGTVRSRIF 716540012885 HMMPfam hit to PF04542, Sigma-70 region, score 8.4e-21 716540012886 PS01063 Sigma-70 factors ECF subfamily signature. 716540012887 L-aspartate oxidase; Provisional; Region: PRK06175 716540012888 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 716540012889 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 716540012890 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716540012891 S-adenosylmethionine binding site [chemical binding]; other site 716540012892 HMMPfam hit to PF05175, Methyltransferase small domain, score 0.00028 716540012893 PS00092 N-6 Adenine-specific DNA methylases signature. 716540012894 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 716540012895 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 716540012896 ATP binding site [chemical binding]; other site 716540012897 Mg++ binding site [ion binding]; other site 716540012898 motif III; other site 716540012899 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 716540012900 nucleotide binding region [chemical binding]; other site 716540012901 ATP-binding site [chemical binding]; other site 716540012902 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 5.8e-68 716540012903 PS00017 ATP/GTP-binding site motif A (P-loop). 716540012904 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 716540012905 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 1.5e-30 716540012906 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 716540012907 ligand binding site [chemical binding]; other site 716540012908 active site 716540012909 UGI interface [polypeptide binding]; other site 716540012910 catalytic site [active] 716540012911 PS00017 ATP/GTP-binding site motif A (P-loop). 716540012912 HMMPfam hit to PF03167, Uracil DNA glycosylase superfamily, score 8.8e-80 716540012913 PS00130 Uracil-DNA glycosylase signature. 716540012914 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 716540012915 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 716540012916 dimer interface [polypeptide binding]; other site 716540012917 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 716540012918 HMMPfam hit to PF01025, GrpE, score 5.9e-67 716540012919 PS01071 grpE protein signature. 716540012920 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 716540012921 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 716540012922 HMMPfam hit to PF01513, ATP-NAD kinase, score 7.3e-100 716540012923 recombination and repair protein; Provisional; Region: PRK10869 716540012924 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 716540012925 Walker A/P-loop; other site 716540012926 ATP binding site [chemical binding]; other site 716540012927 Q-loop/lid; other site 716540012928 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 716540012929 ABC transporter signature motif; other site 716540012930 Walker B; other site 716540012931 D-loop; other site 716540012932 H-loop/switch region; other site 716540012933 HMMPfam hit to PF02463, RecF/RecN/SMC N terminal domain, score 3.2e-11 716540012934 PS00017 ATP/GTP-binding site motif A (P-loop). 716540012935 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 716540012936 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 716540012937 Signal peptide predicted for EAM_2530 by SignalP 2.0 HMM (Signal peptide probability 0.983) with cleavage site probability 0.552 between residues 22 and 23 716540012938 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540012939 HMMPfam hit to PF04355, SmpA / OmlA family, score 2.1e-32 716540012940 hypothetical protein; Validated; Region: PRK01777 716540012941 HMMPfam hit to PF03658, Uncharacterised protein family (UPF0125), score 3e-50 716540012942 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 716540012943 putative coenzyme Q binding site [chemical binding]; other site 716540012944 HMMPfam hit to PF03364, Streptomyces cyclase/dehydrase, score 7.2e-43 716540012945 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 716540012946 SmpB-tmRNA interface; other site 716540012947 HMMPfam hit to PF01668, SmpB protein, score 1.8e-37 716540012948 PS01317 Protein smpB signature. 716540012949 TIR domain; Region: TIR_2; pfam13676 716540012950 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 716540012951 1 transmembrane helix predicted for EAM_2535 by TMHMM2.0 at aa 7-26 716540012952 Signal peptide predicted for EAM_2535 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.974 between residues 25 and 26 716540012953 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 716540012954 HMMPfam hit to PF05159, Capsule polysaccharide biosynthesis pro, score 4.6e-81 716540012955 HMMPfam hit to PF05159, Capsule polysaccharide biosynthesis pro, score 9.6e-93 716540012956 PS00214 Cytosolic fatty-acid binding proteins signature. 716540012957 PS00017 ATP/GTP-binding site motif A (P-loop). 716540012958 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 716540012959 putative CheA interaction surface; other site 716540012960 HMMPfam hit to PF01584, CheW-like domain, score 9.2e-28 716540012961 chemotaxis protein CheA; Provisional; Region: PRK10547 716540012962 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 716540012963 putative binding surface; other site 716540012964 active site 716540012965 CheY binding; Region: CheY-binding; pfam09078 716540012966 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 716540012967 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716540012968 ATP binding site [chemical binding]; other site 716540012969 Mg2+ binding site [ion binding]; other site 716540012970 G-X-G motif; other site 716540012971 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 716540012972 HMMPfam hit to PF01584, CheW-like domain, score 1.4e-21 716540012973 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 5e-27 716540012974 HMMPfam hit to PF02895, Signal transducing histidine kinase, hom, score 2.4e-17 716540012975 HMMPfam hit to PF01627, Hpt domain, score 2.4e-13 716540012976 flagellar motor protein MotB; Validated; Region: motB; PRK09041 716540012977 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 716540012978 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 716540012979 ligand binding site [chemical binding]; other site 716540012980 HMMPfam hit to PF00691, OmpA family, score 7.6e-12 716540012981 Signal peptide predicted for EAM_2539 by SignalP 2.0 HMM (Signal peptide probability 0.939) with cleavage site probability 0.572 between residues 49 and 50 716540012982 1 transmembrane helix predicted for EAM_2539 by TMHMM2.0 at aa 25-47 716540012983 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 716540012984 flagellar motor protein MotA; Validated; Region: PRK09110 716540012985 PS01307 Flagellar motor protein motA family signature. 716540012986 5 transmembrane helices predicted for EAM_2540 by TMHMM2.0 at aa 2-24, 34-51, 64-86, 172-191 and 198-220 716540012987 transcriptional activator FlhC; Provisional; Region: PRK12722 716540012988 HMMPfam hit to PF05280, Flagellar transcriptional activator (FlhC), score 1.3e-91 716540012989 transcriptional activator FlhD; Provisional; Region: PRK02909 716540012990 HMMPfam hit to PF05247, Flagellar transcriptional activator (FlhD), score 1e-40 716540012991 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 716540012992 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 716540012993 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 716540012994 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 716540012995 DNA binding residues [nucleotide binding] 716540012996 HMMPfam hit to PF04545, Sigma-70, region, score 5.6e-11 716540012997 HMMPfam hit to PF08281, Sigma-70, region, score 0.0048 716540012998 PS00716 Sigma-70 factors family signature 2. 716540012999 Predicted helix-turn-helix motif with score 1034.000, SD 2.71 at aa 205-226, sequence LNMREIGAVLSLTETRVSQLHS 716540013000 HMMPfam hit to PF04539, Sigma-70 region, score 1.1e-06 716540013001 HMMPfam hit to PF04542, Sigma-70 region, score 1.1e-11 716540013002 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 716540013003 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 716540013004 dimerization interface [polypeptide binding]; other site 716540013005 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 716540013006 dimer interface [polypeptide binding]; other site 716540013007 putative CheW interface [polypeptide binding]; other site 716540013008 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 1.3e-92 716540013009 HMMPfam hit to PF00672, HAMP domain, score 2.4e-11 716540013010 2 transmembrane helices predicted for EAM_2544 by TMHMM2.0 at aa 10-32 and 186-208 716540013011 Signal peptide predicted for EAM_2544 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.748 between residues 30 and 31 716540013012 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 716540013013 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 716540013014 HMMPfam hit to PF00669, Bacterial flagellin N-terminus, score 1.3e-06 716540013015 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 716540013016 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 716540013017 HMMPfam hit to PF06429, Domain of unknown function (DUF1078), score 1.4e-10 716540013018 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 716540013019 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 716540013020 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 716540013021 HMMPfam hit to PF01832, Mannosyl-glycoprotein endo-beta-N-ace, score 9.6e-51 716540013022 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 716540013023 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 716540013024 HMMPfam hit to PF02119, Flagellar P-ring protein, score 2.3e-190 716540013025 Signal peptide predicted for EAM_2548 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.521 between residues 28 and 29 716540013026 1 transmembrane helix predicted for EAM_2548 by TMHMM2.0 at aa 7-26 716540013027 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 716540013028 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12696 716540013029 HMMPfam hit to PF02107, Flagellar L-ring protein, score 9.4e-79 716540013030 Signal peptide predicted for EAM_2549 by SignalP 2.0 HMM (Signal peptide probability 0.627) with cleavage site probability 0.339 between residues 32 and 33 716540013031 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540013032 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 716540013033 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 716540013034 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 716540013035 HMMPfam hit to PF06429, Domain of unknown function (DUF1078), score 1.1e-17 716540013036 HMMPfam hit to PF00460, Flagella basal body rod protein, score 3.3e-12 716540013037 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 716540013038 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 716540013039 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 716540013040 HMMPfam hit to PF06429, Domain of unknown function (DUF1078), score 3.9e-07 716540013041 HMMPfam hit to PF00460, Flagella basal body rod protein, score 1e-09 716540013042 PS00588 Flagella basal body rod proteins signature. 716540013043 Signal peptide predicted for EAM_2551 by SignalP 2.0 HMM (Signal peptide probability 0.625) with cleavage site probability 0.320 between residues 20 and 21 716540013044 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 716540013045 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 716540013046 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 716540013047 HMMPfam hit to PF06429, Domain of unknown function (DUF1078), score 4.3e-20 716540013048 HMMPfam hit to PF07559, Flagellar basal body protein FlaE, score 4.7e-24 716540013049 HMMPfam hit to PF00460, Flagella basal body rod protein, score 5.1e-10 716540013050 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 716540013051 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 716540013052 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 716540013053 HMMPfam hit to PF03963, Flagellar hook capping protein, score 5e-22 716540013054 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 716540013055 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 716540013056 HMMPfam hit to PF06429, Domain of unknown function (DUF1078), score 2.2e-07 716540013057 HMMPfam hit to PF00460, Flagella basal body rod protein, score 1.6e-07 716540013058 PS00588 Flagella basal body rod proteins signature. 716540013059 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 716540013060 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 716540013061 HMMPfam hit to PF00460, Flagella basal body rod protein, score 5.6e-10 716540013062 PS00588 Flagella basal body rod proteins signature. 716540013063 SAF-like; Region: SAF_2; pfam13144 716540013064 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 716540013065 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 716540013066 Signal peptide predicted for EAM_2556 by SignalP 2.0 HMM (Signal peptide probability 0.979) with cleavage site probability 0.775 between residues 20 and 21 716540013067 HMMPfam hit to PF03240, FlgA family, score 3.2e-35 716540013068 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 716540013069 FlgN protein; Region: FlgN; cl09176 716540013070 HMMPfam hit to PF05130, FlgN protein, score 8.7e-16 716540013071 Flagellar protein FliT; Region: FliT; pfam05400 716540013072 Flagellar protein FliS; Region: FliS; cl00654 716540013073 HMMPfam hit to PF02561, Flagellar protein FliS, score 3.5e-29 716540013074 flagellar capping protein; Reviewed; Region: fliD; PRK08032 716540013075 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 716540013076 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 716540013077 HMMPfam hit to PF07195, Flagellar hook-associated protein, score 1.3e-49 716540013078 HMMPfam hit to PF07196, Flagellin hook IN motif, score 2.7e-09 716540013079 HMMPfam hit to PF02465, Flagellar hook-associated protein, score 4.6e-19 716540013080 flagellin; Validated; Region: PRK08026 716540013081 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 716540013082 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 716540013083 HMMPfam hit to PF00669, Bacterial flagellin N-terminus, score 1.8e-65 716540013084 HMMPfam hit to PF00700, Bacterial flagellin C-terminus, score 2e-28 716540013085 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 716540013086 DNA binding site [nucleotide binding] 716540013087 HMMPfam hit to PF00486, Transcriptional regulatory protein, C ter, score 5.5e-11 716540013088 1 transmembrane helix predicted for EAM_2563 by TMHMM2.0 at aa 150-172 716540013089 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 716540013090 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 716540013091 putative CoA binding site [chemical binding]; other site 716540013092 putative trimer interface [polypeptide binding]; other site 716540013093 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 716540013094 trimer interface [polypeptide binding]; other site 716540013095 active site 716540013096 substrate binding site [chemical binding]; other site 716540013097 CoA binding site [chemical binding]; other site 716540013098 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 65 716540013099 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.32 716540013100 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 28 716540013101 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.33 716540013102 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 716540013103 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 716540013104 inhibitor-cofactor binding pocket; inhibition site 716540013105 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716540013106 catalytic residue [active] 716540013107 HMMPfam hit to PF01041, DegT/DnrJ/EryC1/StrS aminotransferase, score 7.4e-96 716540013108 HMMPfam hit to PF01212, Beta-eliminating lyase, score 2.5e-05 716540013109 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 716540013110 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716540013111 S-adenosylmethionine binding site [chemical binding]; other site 716540013112 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 716540013113 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 716540013114 TPR motif; other site 716540013115 binding surface 716540013116 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 716540013117 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 716540013118 HMMPfam hit to PF08241, Methyltransferase domain, score 0.0007 716540013119 HMMPfam hit to PF08242, Methyltransferase domain, score 4.7e-07 716540013120 Signal peptide predicted for EAM_2567 by SignalP 2.0 HMM (Signal peptide probability 0.764) with cleavage site probability 0.652 between residues 27 and 28 716540013121 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540013122 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 716540013123 HMMPfam hit to PF01311, Bacterial export proteins, family, score 8.9e-59 716540013124 6 transmembrane helices predicted for EAM_2568 by TMHMM2.0 at aa 15-34, 47-69, 79-96, 128-150, 182-204 and 211-233 716540013125 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 716540013126 HMMPfam hit to PF01313, Bacterial export proteins, family, score 8.3e-29 716540013127 2 transmembrane helices predicted for EAM_2569 by TMHMM2.0 at aa 16-38 and 48-70 716540013128 Signal peptide predicted for EAM_2569 by SignalP 2.0 HMM (Signal peptide probability 0.982) with cleavage site probability 0.959 between residues 40 and 41 716540013129 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 716540013130 HMMPfam hit to PF00813, FliP family, score 7.7e-117 716540013131 5 transmembrane helices predicted for EAM_2570 by TMHMM2.0 at aa 5-27, 47-69, 90-107, 187-209 and 216-238 716540013132 PS01061 Flagella transport protein fliP family signature 2. 716540013133 PS01060 Flagella transport protein fliP family signature 1. 716540013134 Signal peptide predicted for EAM_2570 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.937 between residues 24 and 25 716540013135 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 716540013136 HMMPfam hit to PF04347, Flagellar biosynthesis protein, FliO, score 7.6e-18 716540013137 1 transmembrane helix predicted for EAM_2571 by TMHMM2.0 at aa 22-44 716540013138 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 716540013139 HMMPfam hit to PF01052, Surface presentation of antigens (SPOA) prot, score 2.4e-35 716540013140 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 716540013141 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 716540013142 HMMPfam hit to PF01052, Surface presentation of antigens (SPOA) prot, score 0.031 716540013143 HMMPfam hit to PF02154, Flagellar motor switch protein FliM, score 1.3e-94 716540013144 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 716540013145 HMMPfam hit to PF03748, Flagellar basal body-associated protein FliL, score 1.9e-22 716540013146 Signal peptide predicted for EAM_2574 by SignalP 2.0 HMM (Signal peptide probability 0.954) with cleavage site probability 0.339 between residues 54 and 55 716540013147 1 transmembrane helix predicted for EAM_2574 by TMHMM2.0 at aa 15-37 716540013148 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 716540013149 HMMPfam hit to PF02120, Flagellar hook-length control protein, score 3.2e-29 716540013150 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 716540013151 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 716540013152 HMMPfam hit to PF02050, Flagellar FliJ protein, score 1.6e-16 716540013153 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 716540013154 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 716540013155 Walker A motif/ATP binding site; other site 716540013156 Walker B motif; other site 716540013157 HMMPfam hit to PF00006, ATP synthase alpha/beta family, nucleotid, score 3.2e-117 716540013158 PS00152 ATP synthase alpha and beta subunits signature. 716540013159 PS00017 ATP/GTP-binding site motif A (P-loop). 716540013160 flagellar assembly protein H; Validated; Region: fliH; PRK05687 716540013161 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 716540013162 Flagellar assembly protein FliH; Region: FliH; pfam02108 716540013163 HMMPfam hit to PF02108, Flagellar assembly protein FliH, score 3.2e-39 716540013164 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 716540013165 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 716540013166 FliG C-terminal domain; Region: FliG_C; pfam01706 716540013167 HMMPfam hit to PF01706, FliG C-terminal domain, score 1.2e-51 716540013168 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 716540013169 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 716540013170 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 716540013171 2 transmembrane helices predicted for EAM_2580 by TMHMM2.0 at aa 29-48 and 456-478 716540013172 HMMPfam hit to PF08345, Flagellar M-ring protein C-terminal, score 1.9e-73 716540013173 PS00017 ATP/GTP-binding site motif A (P-loop). 716540013174 HMMPfam hit to PF01514, Secretory protein of YscJ/FliF family, score 5.5e-75 716540013175 Signal peptide predicted for EAM_2580 by SignalP 2.0 HMM (Signal peptide probability 0.676) with cleavage site probability 0.673 between residues 49 and 50 716540013176 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 716540013177 HMMPfam hit to PF02049, Flagellar hook-basal body complex protein Fl, score 3.8e-22 716540013178 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 716540013179 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 716540013180 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716540013181 HMMPfam hit to PF03705, CheR methyltransferase, all-alpha domain, score 3.1e-12 716540013182 HMMPfam hit to PF01739, CheR methyltransferase, SAM binding domain, score 1.1e-67 716540013183 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 716540013184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716540013185 active site 716540013186 phosphorylation site [posttranslational modification] 716540013187 intermolecular recognition site; other site 716540013188 dimerization interface [polypeptide binding]; other site 716540013189 CheB methylesterase; Region: CheB_methylest; pfam01339 716540013190 HMMPfam hit to PF00072, Response regulator receiver domain, score 8.4e-28 716540013191 HMMPfam hit to PF01339, CheB methylesterase, score 1.3e-98 716540013192 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 716540013193 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716540013194 active site 716540013195 phosphorylation site [posttranslational modification] 716540013196 intermolecular recognition site; other site 716540013197 dimerization interface [polypeptide binding]; other site 716540013198 HMMPfam hit to PF00072, Response regulator receiver domain, score 3.9e-42 716540013199 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 716540013200 HMMPfam hit to PF04344, Chemotaxis phosphatase, CheZ, score 9.7e-67 716540013201 PS00215 Mitochondrial energy transfer proteins signature. 716540013202 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 716540013203 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 716540013204 HMMPfam hit to PF01312, FlhB HrpN YscU SpaS Family, score 8.2e-131 716540013205 4 transmembrane helices predicted for EAM_2586 by TMHMM2.0 at aa 36-58, 96-118, 149-166 and 189-211 716540013206 PS00017 ATP/GTP-binding site motif A (P-loop). 716540013207 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 716540013208 FHIPEP family; Region: FHIPEP; pfam00771 716540013209 Signal peptide predicted for EAM_2587 by SignalP 2.0 HMM (Signal peptide probability 0.894) with cleavage site probability 0.880 between residues 42 and 43 716540013210 7 transmembrane helices predicted for EAM_2587 by TMHMM2.0 at aa 20-42, 46-63, 75-97, 117-139, 208-230, 250-272 and 292-326 716540013211 HMMPfam hit to PF00771, FHIPEP family, score 0 716540013212 PS00994 Bacterial export FHIPEP family signature. 716540013213 Flagellar protein FlhE; Region: FlhE; pfam06366 716540013214 HMMPfam hit to PF06366, Flagellar protein FlhE, score 4.3e-39 716540013215 Signal peptide predicted for EAM_2588 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.700 between residues 21 and 22 716540013216 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 716540013217 Signal peptide predicted for EAM_2589 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.974 between residues 22 and 23 716540013218 HMMPfam hit to PF03502, Nucleoside-specific channel-forming prote, score 3.6e-85 716540013219 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 716540013220 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716540013221 Coenzyme A binding pocket [chemical binding]; other site 716540013222 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 5.2e-19 716540013223 Signal peptide predicted for EAM_2591 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.771 between residues 24 and 25 716540013224 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540013225 hypothetical protein; Provisional; Region: PRK10556 716540013226 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 716540013227 catalytic residues [active] 716540013228 HMMPfam hit to PF00462, Glutaredoxin, score 3.9e-16 716540013229 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 716540013230 HMMPfam hit to PF07972, NrdI Flavodoxin like, score 2e-74 716540013231 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 716540013232 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 716540013233 Class I ribonucleotide reductase; Region: RNR_I; cd01679 716540013234 active site 716540013235 dimer interface [polypeptide binding]; other site 716540013236 catalytic residues [active] 716540013237 effector binding site; other site 716540013238 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 716540013239 HMMPfam hit to PF08343, Ribonucleotide reductase N-terminal, score 1.5e-43 716540013240 HMMPfam hit to PF00317, Ribonucleotide reductase, all-alpha d, score 8.2e-25 716540013241 HMMPfam hit to PF02867, Ribonucleotide reductase, barrel doma, score 3e-225 716540013242 PS00089 Ribonucleotide reductase large subunit signature. 716540013243 Predicted helix-turn-helix motif with score 1105.000, SD 2.95 at aa 667-688, sequence LFFRDTATTRDINRAQIYAWKK 716540013244 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 716540013245 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 716540013246 dimer interface [polypeptide binding]; other site 716540013247 putative radical transfer pathway; other site 716540013248 diiron center [ion binding]; other site 716540013249 tyrosyl radical; other site 716540013250 HMMPfam hit to PF00268, Ribonucleotide reductase, small chain, score 2.1e-102 716540013251 PS00368 Ribonucleotide reductase small subunit signature. 716540013252 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 716540013253 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 716540013254 Walker A/P-loop; other site 716540013255 ATP binding site [chemical binding]; other site 716540013256 Q-loop/lid; other site 716540013257 ABC transporter signature motif; other site 716540013258 Walker B; other site 716540013259 D-loop; other site 716540013260 H-loop/switch region; other site 716540013261 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 716540013262 HMMPfam hit to PF00005, ABC transporter, score 5.5e-65 716540013263 PS00017 ATP/GTP-binding site motif A (P-loop). 716540013264 PS00211 ABC transporters family signature. 716540013265 HMMPfam hit to PF00571, CBS domain pair, score 0.0004 716540013266 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 716540013267 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540013268 dimer interface [polypeptide binding]; other site 716540013269 conserved gate region; other site 716540013270 putative PBP binding loops; other site 716540013271 ABC-ATPase subunit interface; other site 716540013272 6 transmembrane helices predicted for EAM_2599 by TMHMM2.0 at aa 129-151, 156-178, 182-204, 225-256, 302-324 and 331-353 716540013273 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 7.5e-35 716540013274 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 716540013275 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 716540013276 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 716540013277 Signal peptide predicted for EAM_2600 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.975 between residues 21 and 22 716540013278 HMMPfam hit to PF04069, Substrate binding domain of ABC-type glycine, score 3.5e-61 716540013279 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 716540013280 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540013281 Signal peptide predicted for EAM_2601 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.801 between residues 25 and 26 716540013282 10 transmembrane helices predicted for EAM_2601 by TMHMM2.0 at aa 7-29, 48-70, 77-96, 106-128, 135-154, 164-186, 217-239, 293-315, 336-358 and 362-384 716540013283 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 3.6e-44 716540013284 transcriptional repressor MprA; Provisional; Region: PRK10870 716540013285 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 716540013286 HMMPfam hit to PF01047, MarR family, score 2.3e-25 716540013287 PS01117 Bacterial regulatory proteins, marR family signature. 716540013288 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 716540013289 ATP P2X receptor; Region: P2X_receptor; cl02993 716540013290 HlyD family secretion protein; Region: HlyD_3; pfam13437 716540013291 1 transmembrane helix predicted for EAM_2604 by TMHMM2.0 at aa 23-45 716540013292 HMMPfam hit to PF00529, HlyD family secretion protein, score 1.8e-80 716540013293 PS00012 Phosphopantetheine attachment site. 716540013294 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 716540013295 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540013296 putative substrate translocation pore; other site 716540013297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540013298 Signal peptide predicted for EAM_2605 by SignalP 2.0 HMM (Signal peptide probability 0.968) with cleavage site probability 0.499 between residues 34 and 35 716540013299 13 transmembrane helices predicted for EAM_2605 by TMHMM2.0 at aa 5-27, 51-73, 80-94, 104-126, 138-160, 164-183, 196-218, 233-250, 271-290, 300-322, 335-352, 367-389 and 479-497 716540013300 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.2e-58 716540013301 putative methyltransferase; Provisional; Region: PRK10864 716540013302 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 716540013303 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 716540013304 HMMPfam hit to PF00588, SpoU rRNA Methylase family, score 1e-36 716540013305 HMMPfam hit to PF08032, RNA 2'-O ribose methyltransferase subs, score 4.8e-14 716540013306 thioredoxin 2; Provisional; Region: PRK10996 716540013307 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 716540013308 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 716540013309 catalytic residues [active] 716540013310 HMMPfam hit to PF00085, Thioredoxin, score 9.3e-35 716540013311 PS00194 Thioredoxin family active site. 716540013312 Uncharacterized conserved protein [Function unknown]; Region: COG3148 716540013313 HMMPfam hit to PF03942, DTW domain, score 1.8e-68 716540013314 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 716540013315 CoA binding domain; Region: CoA_binding_2; pfam13380 716540013316 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 716540013317 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 716540013318 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 716540013319 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 716540013320 HMMPfam hit to PF02629, CoA binding domain, score 0.018 716540013321 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 5e-10 716540013322 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 716540013323 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 716540013324 domain interface [polypeptide binding]; other site 716540013325 putative active site [active] 716540013326 catalytic site [active] 716540013327 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 716540013328 domain interface [polypeptide binding]; other site 716540013329 putative active site [active] 716540013330 catalytic site [active] 716540013331 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 0.00014 716540013332 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 1.9e-06 716540013333 lipoprotein; Provisional; Region: PRK10759 716540013334 Signal peptide predicted for EAM_2611 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.481 between residues 20 and 21 716540013335 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 716540013336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540013337 putative substrate translocation pore; other site 716540013338 HMMPfam hit to PF00083, Sugar (and other) transporter, score 1.5e-25 716540013339 12 transmembrane helices predicted for EAM_2612 by TMHMM2.0 at aa 21-43, 63-85, 97-114, 119-141, 161-183, 198-215, 245-267, 282-304, 311-333, 338-360, 373-395 and 405-424 716540013340 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 7.6e-18 716540013341 PS00216 Sugar transport proteins signature 1. 716540013342 PS00217 Sugar transport proteins signature 2. 716540013343 protein disaggregation chaperone; Provisional; Region: PRK10865 716540013344 Clp amino terminal domain; Region: Clp_N; pfam02861 716540013345 Clp amino terminal domain; Region: Clp_N; pfam02861 716540013346 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716540013347 Walker A motif; other site 716540013348 ATP binding site [chemical binding]; other site 716540013349 Walker B motif; other site 716540013350 arginine finger; other site 716540013351 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716540013352 Walker A motif; other site 716540013353 ATP binding site [chemical binding]; other site 716540013354 Walker B motif; other site 716540013355 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 716540013356 PS00017 ATP/GTP-binding site motif A (P-loop). 716540013357 HMMPfam hit to PF07724, ATPase family associated with various cellul, score 7.8e-112 716540013358 HMMPfam hit to PF07728, ATPase family associated with various cellul, score 6e-07 716540013359 PS00871 Chaperonins clpA/B signature 2. 716540013360 PS00017 ATP/GTP-binding site motif A (P-loop). 716540013361 PS00017 ATP/GTP-binding site motif A (P-loop). 716540013362 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 7.9e-12 716540013363 PS00870 Chaperonins clpA/B signature 1. 716540013364 PS00017 ATP/GTP-binding site motif A (P-loop). 716540013365 HMMPfam hit to PF02861, Clp amino terminal domain, score 2.9e-13 716540013366 HMMPfam hit to PF02861, Clp amino terminal domain, score 3.8e-17 716540013367 hypothetical protein; Provisional; Region: PRK10723 716540013368 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 716540013369 HMMPfam hit to PF02578, Uncharacterised ACR, YfiH family COG1496, score 1.6e-81 716540013370 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 716540013371 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 716540013372 RNA binding surface [nucleotide binding]; other site 716540013373 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 716540013374 active site 716540013375 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 3.4e-67 716540013376 PS01129 Rlu family of pseudouridine synthase signature. 716540013377 HMMPfam hit to PF01479, S4 domain, score 9.6e-13 716540013378 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 716540013379 Signal peptide predicted for EAM_2616 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.599 between residues 26 and 27 716540013380 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540013381 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 716540013382 30S subunit binding site; other site 716540013383 HMMPfam hit to PF02482, Sigma 54 modulation protein / S30EA r, score 2.4e-43 716540013384 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 716540013385 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 716540013386 Prephenate dehydratase; Region: PDT; pfam00800 716540013387 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 716540013388 putative L-Phe binding site [chemical binding]; other site 716540013389 HMMPfam hit to PF01817, Chorismate mutase type II, score 6.5e-28 716540013390 HMMPfam hit to PF00800, Prephenate dehydratase, score 1e-96 716540013391 PS00857 Prephenate dehydratase signature 1. 716540013392 PS00858 Prephenate dehydratase signature 2. 716540013393 1 transmembrane helix predicted for EAM_2619 by TMHMM2.0 at aa 15-37 716540013394 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 716540013395 Chorismate mutase type II; Region: CM_2; cl00693 716540013396 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 716540013397 prephenate dehydrogenase; Validated; Region: PRK08507 716540013398 HMMPfam hit to PF02153, Prephenate dehydrogenase, score 5.1e-19 716540013399 HMMPfam hit to PF01817, Chorismate mutase type II, score 9e-31 716540013400 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 716540013401 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 716540013402 HMMPfam hit to PF00793, DAHP synthetase I family, score 4.7e-159 716540013403 PPR repeat family; Region: PPR_2; pfam13041 716540013404 PPR repeat; Region: PPR; cl03252 716540013405 HMMPfam hit to PF01535, PPR repeat, score 0.09 716540013406 HMMPfam hit to PF01535, PPR repeat, score 0.00076 716540013407 HMMPfam hit to PF01535, PPR repeat, score 0.00074 716540013408 HMMPfam hit to PF01535, PPR repeat, score 0.0086 716540013409 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 716540013410 HMMPfam hit to PF01245, Ribosomal protein L19, score 1.1e-76 716540013411 PS01015 Ribosomal protein L19 signature. 716540013412 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 716540013413 HMMPfam hit to PF01746, tRNA (Guanine-1)-methyltransferase, score 1.2e-89 716540013414 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 716540013415 RimM N-terminal domain; Region: RimM; pfam01782 716540013416 PRC-barrel domain; Region: PRC; pfam05239 716540013417 HMMPfam hit to PF05239, PRC-barrel domain, score 2.7e-12 716540013418 HMMPfam hit to PF01782, RimM N-terminal domain, score 1.4e-33 716540013419 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 716540013420 HMMPfam hit to PF00886, Ribosomal protein S16, score 7.9e-33 716540013421 PS00732 Ribosomal protein S16 signature. 716540013422 signal recognition particle protein; Provisional; Region: PRK10867 716540013423 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 716540013424 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 716540013425 P loop; other site 716540013426 GTP binding site [chemical binding]; other site 716540013427 Signal peptide binding domain; Region: SRP_SPB; pfam02978 716540013428 HMMPfam hit to PF02978, Signal peptide binding domain, score 3.3e-51 716540013429 HMMPfam hit to PF00448, SRP54-type protein, GTPase domain, score 8.1e-122 716540013430 PS00300 SRP54-type proteins GTP-binding domain signature. 716540013431 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 716540013432 PS00017 ATP/GTP-binding site motif A (P-loop). 716540013433 HMMPfam hit to PF02881, SRP54-type protein, helical bundle domain, score 1.2e-33 716540013434 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 716540013435 Signal peptide predicted for EAM_2631 by SignalP 2.0 HMM (Signal peptide probability 0.964) with cleavage site probability 0.426 between residues 48 and 49 716540013436 8 transmembrane helices predicted for EAM_2631 by TMHMM2.0 at aa 2-24, 34-56, 61-83, 93-115, 128-150, 175-197, 209-226 and 236-258 716540013437 HMMPfam hit to PF01578, Cytochrome C assembly protein, score 5.7e-62 716540013438 hypothetical protein; Provisional; Region: PRK11573 716540013439 Domain of unknown function DUF21; Region: DUF21; pfam01595 716540013440 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 716540013441 Transporter associated domain; Region: CorC_HlyC; smart01091 716540013442 HMMPfam hit to PF01595, Domain of unknown function DUF21, score 2.3e-59 716540013443 3 transmembrane helices predicted for EAM_2632 by TMHMM2.0 at aa 47-69, 79-97 and 109-131 716540013444 HMMPfam hit to PF00571, CBS domain pair, score 1e-16 716540013445 HMMPfam hit to PF03471, Transporter associated domain, score 2.5e-18 716540013446 S-ribosylhomocysteinase; Provisional; Region: PRK02260 716540013447 HMMPfam hit to PF02664, S-Ribosylhomocysteinase (LuxS), score 1.1e-107 716540013448 glutamate--cysteine ligase; Provisional; Region: PRK02107 716540013449 HMMPfam hit to PF04262, Glutamate-cysteine ligase, score 1e-249 716540013450 Predicted membrane protein [Function unknown]; Region: COG1238 716540013451 3 transmembrane helices predicted for EAM_2635 by TMHMM2.0 at aa 43-65, 86-108 and 113-135 716540013452 Signal peptide predicted for EAM_2635 by SignalP 2.0 HMM (Signal peptide probability 0.902) with cleavage site probability 0.838 between residues 27 and 28 716540013453 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 716540013454 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716540013455 motif II; other site 716540013456 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 3.6e-31 716540013457 carbon storage regulator; Provisional; Region: PRK01712 716540013458 HMMPfam hit to PF02599, Global regulator protein family, score 5e-34 716540013459 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 716540013460 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 716540013461 motif 1; other site 716540013462 active site 716540013463 motif 2; other site 716540013464 motif 3; other site 716540013465 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 716540013466 DHHA1 domain; Region: DHHA1; pfam02272 716540013467 HMMPfam hit to PF02272, DHHA1 domain, score 7.7e-22 716540013468 HMMPfam hit to PF07973, Threonyl and Alanyl tRNA synthetase seco, score 6.3e-22 716540013469 HMMPfam hit to PF01411, tRNA synthetases class II (A), score 0 716540013470 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 716540013471 recombination regulator RecX; Reviewed; Region: recX; PRK00117 716540013472 HMMPfam hit to PF02631, RecX family, score 4.8e-28 716540013473 recombinase A; Provisional; Region: recA; PRK09354 716540013474 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 716540013475 hexamer interface [polypeptide binding]; other site 716540013476 Walker A motif; other site 716540013477 ATP binding site [chemical binding]; other site 716540013478 Walker B motif; other site 716540013479 HMMPfam hit to PF00154, recA bacterial DNA recombination protein, score 1.5e-241 716540013480 PS00321 recA signature. 716540013481 PS00017 ATP/GTP-binding site motif A (P-loop). 716540013482 PS00017 ATP/GTP-binding site motif A (P-loop). 716540013483 hypothetical protein; Validated; Region: PRK03661 716540013484 HMMPfam hit to PF02464, Competence-damaged protein, score 2.4e-76 716540013485 Transglycosylase SLT domain; Region: SLT_2; pfam13406 716540013486 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 716540013487 N-acetyl-D-glucosamine binding site [chemical binding]; other site 716540013488 catalytic residue [active] 716540013489 PS00387 Inorganic pyrophosphatase signature. 716540013490 Signal peptide predicted for EAM_2642 by SignalP 2.0 HMM (Signal peptide probability 0.986) with cleavage site probability 0.449 between residues 23 and 24 716540013491 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540013492 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 716540013493 Signal peptide predicted for EAM_2643 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.558 between residues 25 and 26 716540013494 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540013495 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 716540013496 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 716540013497 catalytic residues [active] 716540013498 hinge region; other site 716540013499 alpha helical domain; other site 716540013500 HMMPfam hit to PF01323, DSBA-like thioredoxin domain, score 1.9e-21 716540013501 PS00194 Thioredoxin family active site. 716540013502 Signal peptide predicted for EAM_2644 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 26 and 27 716540013503 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 716540013504 DNA binding site [nucleotide binding] 716540013505 HMMPfam hit to PF00486, Transcriptional regulatory protein, C ter, score 2.7e-07 716540013506 type III secretion system 2 716540013507 Phosphopantetheine attachment site; Region: PP-binding; cl09936 716540013508 Invasion plasmid antigen IpaD; Region: IpaD; cl05827 716540013509 PS00192 Cytochrome b/b6 heme-ligand signature. 716540013510 Secretion system effector C (SseC) like family; Region: SseC; pfam04888 716540013511 HMMPfam hit to PF03518, Salmonella/Shigella invasin protein B, score 2e-26 716540013512 2 transmembrane helices predicted for EAM_2654 by TMHMM2.0 at aa 367-389 and 456-478 716540013513 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 716540013514 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 716540013515 binding surface 716540013516 TPR motif; other site 716540013517 HMMPfam hit to PF07720, Tetratricopeptide repeat, score 2e-08 716540013518 HMMPfam hit to PF07720, Tetratricopeptide repeat, score 2.3e-10 716540013519 HMMPfam hit to PF02205, WH2 motif, score 0.18 716540013520 type III secretion system protein SpaS; Validated; Region: PRK08156 716540013521 HMMPfam hit to PF01312, FlhB HrpN YscU SpaS Family, score 8.2e-108 716540013522 4 transmembrane helices predicted for EAM_2656 by TMHMM2.0 at aa 28-45, 76-98, 138-157 and 181-203 716540013523 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 716540013524 HMMPfam hit to PF01311, Bacterial export proteins, family, score 8.6e-40 716540013525 6 transmembrane helices predicted for EAM_2657 by TMHMM2.0 at aa 13-35, 42-64, 79-101, 125-147, 184-206 and 213-235 716540013526 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 716540013527 HMMPfam hit to PF01313, Bacterial export proteins, family, score 2.8e-23 716540013528 2 transmembrane helices predicted for EAM_2658 by TMHMM2.0 at aa 13-35 and 45-67 716540013529 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 716540013530 HMMPfam hit to PF00813, FliP family, score 2.9e-94 716540013531 4 transmembrane helices predicted for EAM_2659 by TMHMM2.0 at aa 7-29, 44-66, 159-181 and 186-208 716540013532 PS01061 Flagella transport protein fliP family signature 2. 716540013533 Signal peptide predicted for EAM_2659 by SignalP 2.0 HMM (Signal peptide probability 0.929) with cleavage site probability 0.577 between residues 43 and 44 716540013534 type III secretion system protein SpaO; Validated; Region: PRK08158 716540013535 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 716540013536 HMMPfam hit to PF01052, Surface presentation of antigens (SPOA) prot, score 0.00035 716540013537 ATP synthase SpaL; Validated; Region: PRK08149 716540013538 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 716540013539 Walker A motif; other site 716540013540 ATP binding site [chemical binding]; other site 716540013541 Walker B motif; other site 716540013542 HMMPfam hit to PF00006, ATP synthase alpha/beta family, nucleotid, score 2e-114 716540013543 PS00152 ATP synthase alpha and beta subunits signature. 716540013544 PS00017 ATP/GTP-binding site motif A (P-loop). 716540013545 Invasion protein B family; Region: Invas_SpaK; cl04129 716540013546 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 716540013547 type III secretion system protein InvA; Provisional; Region: PRK15337 716540013548 HMMPfam hit to PF00771, FHIPEP family, score 3.5e-283 716540013549 7 transmembrane helices predicted for EAM_2665 by TMHMM2.0 at aa 13-35, 40-62, 69-91, 106-128, 197-219, 239-261 and 282-304 716540013550 PS00994 Bacterial export FHIPEP family signature. 716540013551 HrpJ-like domain; Region: HrpJ; cl15454 716540013552 HMMPfam hit to PF02523, InvE invasion protein, score 1.7e-07 716540013553 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 716540013554 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 716540013555 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 716540013556 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 716540013557 HMMPfam hit to PF00263, Bacterial type II and III secretion system, score 9.3e-49 716540013558 HMMPfam hit to PF03958, Bacterial type II/III secretion system sho, score 2.7e-14 716540013559 HMMPfam hit to PF03958, Bacterial type II/III secretion system sho, score 3.9e-07 716540013560 Signal peptide predicted for EAM_2667 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.414 between residues 22 and 23 716540013561 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 716540013562 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716540013563 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 3.7e-08 716540013564 Predicted helix-turn-helix motif with score 1105.000, SD 2.95 at aa 195-216, sequence LNVYNVCKAYGVSESQFRKLCH 716540013565 type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327; cl12363 716540013566 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480 716540013567 1 transmembrane helix predicted for EAM_2669 by TMHMM2.0 at aa 162-184 716540013568 Type III secretion needle MxiH like; Region: MxiH; cl09641 716540013569 type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325 716540013570 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 716540013571 HMMPfam hit to PF01514, Secretory protein of YscJ/FliF family, score 1.4e-36 716540013572 Signal peptide predicted for EAM_2672 by SignalP 2.0 HMM (Signal peptide probability 0.743) with cleavage site probability 0.454 between residues 20 and 21 716540013573 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540013574 2 transmembrane helices predicted for EAM_2672 by TMHMM2.0 at aa 181-198 and 213-232 716540013575 Bacterial type III secretion apparatus protein (OrgA_MxiK); Region: OrgA_MxiK; cl09716 716540013576 invasion protein OrgA; Provisional; Region: PRK15323 716540013577 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 716540013578 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 716540013579 N-acetyl-D-glucosamine binding site [chemical binding]; other site 716540013580 catalytic residue [active] 716540013581 Signal peptide predicted for EAM_2676 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.967 between residues 23 and 24 716540013582 HMMPfam hit to PF01464, Transglycosylase SLT domain, score 9e-12 716540013583 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 716540013584 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 716540013585 MutS domain I; Region: MutS_I; pfam01624 716540013586 MutS domain II; Region: MutS_II; pfam05188 716540013587 MutS domain III; Region: MutS_III; pfam05192 716540013588 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 716540013589 Walker A/P-loop; other site 716540013590 ATP binding site [chemical binding]; other site 716540013591 Q-loop/lid; other site 716540013592 ABC transporter signature motif; other site 716540013593 Walker B; other site 716540013594 D-loop; other site 716540013595 H-loop/switch region; other site 716540013596 HMMPfam hit to PF01624, MutS domain I, score 7.8e-72 716540013597 HMMPfam hit to PF05188, MutS domain II, score 7.7e-45 716540013598 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 716540013599 HMMPfam hit to PF05192, MutS domain III, score 4.3e-86 716540013600 HMMPfam hit to PF05190, MutS family domain IV, score 6.8e-41 716540013601 HMMPfam hit to PF00488, MutS domain V, score 1.9e-164 716540013602 PS00017 ATP/GTP-binding site motif A (P-loop). 716540013603 PS00486 DNA mismatch repair proteins mutS family signature. 716540013604 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 716540013605 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 716540013606 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 716540013607 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 716540013608 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 716540013609 DNA binding residues [nucleotide binding] 716540013610 HMMPfam hit to PF04545, Sigma-70, region, score 1.6e-18 716540013611 PS00716 Sigma-70 factors family signature 2. 716540013612 Predicted helix-turn-helix motif with score 1306.000, SD 3.64 at aa 286-307, sequence ATLEDVGREIGLTRERVRQIQV 716540013613 HMMPfam hit to PF04539, Sigma-70 region, score 2.8e-28 716540013614 HMMPfam hit to PF04542, Sigma-70 region, score 6.6e-27 716540013615 PS00715 Sigma-70 factors family signature 1. 716540013616 HMMPfam hit to PF00140, Sigma-70 factor, region, score 3.4e-11 716540013617 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 716540013618 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 716540013619 Peptidase family M23; Region: Peptidase_M23; pfam01551 716540013620 HMMPfam hit to PF01551, Peptidase family M23, score 8.5e-48 716540013621 HMMPfam hit to PF01476, LysM domain, score 2.2e-11 716540013622 Signal peptide predicted for EAM_2680 by SignalP 2.0 HMM (Signal peptide probability 0.980) with cleavage site probability 0.684 between residues 29 and 30 716540013623 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540013624 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 716540013625 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716540013626 S-adenosylmethionine binding site [chemical binding]; other site 716540013627 HMMPfam hit to PF01135, Protein-L-isoaspartate(D-aspartate) O-methyl, score 8e-101 716540013628 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 716540013629 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 716540013630 HMMPfam hit to PF01975, Survival protein SurE, score 6.2e-106 716540013631 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 716540013632 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 716540013633 Permutation of conserved domain; other site 716540013634 active site 716540013635 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 716540013636 HMMPfam hit to PF01142, tRNA pseudouridine synthase D (TruD), score 5.6e-147 716540013637 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 716540013638 homotrimer interaction site [polypeptide binding]; other site 716540013639 zinc binding site [ion binding]; other site 716540013640 CDP-binding sites; other site 716540013641 HMMPfam hit to PF02542, YgbB family, score 5.8e-100 716540013642 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 716540013643 substrate binding site; other site 716540013644 dimer interface; other site 716540013645 HMMPfam hit to PF01128, Uncharacterized protein family UPF0007, score 7.1e-111 716540013646 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 716540013647 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 716540013648 HMMPfam hit to PF04977, Septum formation initiator, score 4.5e-33 716540013649 1 transmembrane helix predicted for EAM_2686 by TMHMM2.0 at aa 4-21 716540013650 hypothetical protein; Provisional; Region: PRK10726 716540013651 3 transmembrane helices predicted for EAM_2687 by TMHMM2.0 at aa 21-43, 53-75 and 82-104 716540013652 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 716540013653 ligand-binding site [chemical binding]; other site 716540013654 HMMPfam hit to PF01583, Adenylylsulphate kinase, score 1.2e-111 716540013655 PS00017 ATP/GTP-binding site motif A (P-loop). 716540013656 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 716540013657 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 716540013658 CysD dimerization site [polypeptide binding]; other site 716540013659 G1 box; other site 716540013660 putative GEF interaction site [polypeptide binding]; other site 716540013661 GTP/Mg2+ binding site [chemical binding]; other site 716540013662 Switch I region; other site 716540013663 G2 box; other site 716540013664 G3 box; other site 716540013665 Switch II region; other site 716540013666 G4 box; other site 716540013667 G5 box; other site 716540013668 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 716540013669 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 716540013670 HMMPfam hit to PF03144, Elongation factor Tu domain, score 6.7e-09 716540013671 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 6.7e-72 716540013672 PS00301 GTP-binding elongation factors signature. 716540013673 PS00017 ATP/GTP-binding site motif A (P-loop). 716540013674 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 716540013675 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 716540013676 Active Sites [active] 716540013677 HMMPfam hit to PF01507, Phosphoadenosine phosphosulfate reductase, score 2.6e-140 716540013678 siroheme synthase; Provisional; Region: cysG; PRK10637 716540013679 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 716540013680 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 716540013681 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 716540013682 active site 716540013683 SAM binding site [chemical binding]; other site 716540013684 homodimer interface [polypeptide binding]; other site 716540013685 HMMPfam hit to PF00590, Tetrapyrrole (Corrin/Porphyrin) Methylas, score 2.7e-81 716540013686 PS00839 Uroporphyrin-III C-methyltransferase signature 1. 716540013687 YCII-related domain; Region: YCII; cl00999 716540013688 HMMPfam hit to PF03795, YCII-related domain, score 8e-08 716540013689 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 716540013690 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 716540013691 Active Sites [active] 716540013692 HMMPfam hit to PF01507, Phosphoadenosine phosphosulfate reductase, score 3.9e-78 716540013693 sulfite reductase subunit beta; Provisional; Region: PRK13504 716540013694 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 716540013695 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 716540013696 PS00365 Nitrite and sulfite reductases iron-sulfur/siroheme-binding site. 716540013697 HMMPfam hit to PF03460, Nitrite/Sulfite reductase ferredoxin-lik, score 4.6e-17 716540013698 HMMPfam hit to PF01077, Nitrite and sulphite reductase 4Fe-4S do, score 1.4e-55 716540013699 HMMPfam hit to PF03460, Nitrite/Sulfite reductase ferredoxin-lik, score 8.8e-20 716540013700 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 716540013701 Flavodoxin; Region: Flavodoxin_1; pfam00258 716540013702 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 716540013703 FAD binding pocket [chemical binding]; other site 716540013704 FAD binding motif [chemical binding]; other site 716540013705 catalytic residues [active] 716540013706 NAD binding pocket [chemical binding]; other site 716540013707 phosphate binding motif [ion binding]; other site 716540013708 beta-alpha-beta structure motif; other site 716540013709 HMMPfam hit to PF00175, Oxidoreductase NAD-binding domain, score 1.4e-32 716540013710 HMMPfam hit to PF00667, FAD binding domain, score 2.2e-56 716540013711 HMMPfam hit to PF00258, Flavodoxin, score 9.1e-37 716540013712 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 716540013713 active site 716540013714 HMMPfam hit to PF01242, 6-pyruvoyl tetrahydropterin synthase, score 1.7e-63 716540013715 Yersinia/Haemophilus virulence surface antigen; Region: Peptidase_C58; cl04145 716540013716 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540013717 dimer interface [polypeptide binding]; other site 716540013718 conserved gate region; other site 716540013719 putative PBP binding loops; other site 716540013720 ABC-ATPase subunit interface; other site 716540013721 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 4.7e-34 716540013722 4 transmembrane helices predicted for EAM_2698 by TMHMM2.0 at aa 20-42, 55-77, 81-103 and 187-209 716540013723 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 716540013724 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 716540013725 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 716540013726 Walker A/P-loop; other site 716540013727 ATP binding site [chemical binding]; other site 716540013728 Q-loop/lid; other site 716540013729 ABC transporter signature motif; other site 716540013730 Walker B; other site 716540013731 D-loop; other site 716540013732 H-loop/switch region; other site 716540013733 HMMPfam hit to PF00005, ABC transporter, score 3.3e-65 716540013734 PS00017 ATP/GTP-binding site motif A (P-loop). 716540013735 PS00211 ABC transporters family signature. 716540013736 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 716540013737 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 716540013738 substrate binding pocket [chemical binding]; other site 716540013739 membrane-bound complex binding site; other site 716540013740 hinge residues; other site 716540013741 Signal peptide predicted for EAM_2700 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.986 between residues 23 and 24 716540013742 HMMPfam hit to PF00497, Bacterial extracellular solute-binding prot, score 1.5e-91 716540013743 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 716540013744 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 716540013745 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 716540013746 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 716540013747 11 transmembrane helices predicted for EAM_2702 by TMHMM2.0 at aa 13-35, 40-62, 69-91, 131-153, 165-182, 186-208, 220-239, 249-271, 278-300, 310-329 and 341-363 716540013748 HMMPfam hit to PF01757, Acyltransferase family, score 3.9e-63 716540013749 enolase; Provisional; Region: eno; PRK00077 716540013750 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 716540013751 dimer interface [polypeptide binding]; other site 716540013752 metal binding site [ion binding]; metal-binding site 716540013753 substrate binding pocket [chemical binding]; other site 716540013754 HMMPfam hit to PF00113, Enolase, C-terminal TIM barrel domain, score 1.7e-184 716540013755 PS00164 Enolase signature. 716540013756 HMMPfam hit to PF03952, Enolase, N-terminal domain, score 4.2e-69 716540013757 CTP synthetase; Validated; Region: pyrG; PRK05380 716540013758 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 716540013759 Catalytic site [active] 716540013760 active site 716540013761 UTP binding site [chemical binding]; other site 716540013762 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 716540013763 active site 716540013764 putative oxyanion hole; other site 716540013765 catalytic triad [active] 716540013766 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 3.9e-80 716540013767 PS00442 Glutamine amidotransferases class-I active site. 716540013768 HMMPfam hit to PF06418, CTP synthase N-terminus, score 7.9e-215 716540013769 1 transmembrane helix predicted for EAM_2704 by TMHMM2.0 at aa 7-29 716540013770 Signal peptide predicted for EAM_2704 by SignalP 2.0 HMM (Signal peptide probability 0.931) with cleavage site probability 0.901 between residues 26 and 27 716540013771 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 716540013772 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 716540013773 homodimer interface [polypeptide binding]; other site 716540013774 metal binding site [ion binding]; metal-binding site 716540013775 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 716540013776 homodimer interface [polypeptide binding]; other site 716540013777 active site 716540013778 putative chemical substrate binding site [chemical binding]; other site 716540013779 metal binding site [ion binding]; metal-binding site 716540013780 HMMPfam hit to PF03819, MazG nucleotide pyrophosphohydrolase domain, score 5.6e-39 716540013781 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 716540013782 HD domain; Region: HD_4; pfam13328 716540013783 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 716540013784 synthetase active site [active] 716540013785 NTP binding site [chemical binding]; other site 716540013786 metal binding site [ion binding]; metal-binding site 716540013787 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 716540013788 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 716540013789 HMMPfam hit to PF01842, ACT domain, score 6.6e-13 716540013790 HMMPfam hit to PF02824, TGS domain, score 4.6e-29 716540013791 HMMPfam hit to PF04607, Region found in RelA / SpoT proteins, score 7.2e-47 716540013792 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 716540013793 TRAM domain; Region: TRAM; pfam01938 716540013794 HMMPfam hit to PF05958, tRNA (Uracil-5-)-methyltransferase, score 7.3e-10 716540013795 PS01231 RNA methyltransferase trmA family signature 2. 716540013796 PS01230 RNA methyltransferase trmA family signature 1. 716540013797 HMMPfam hit to PF01938, TRAM domain, score 9.1e-16 716540013798 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 716540013799 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 716540013800 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 716540013801 dimerization interface [polypeptide binding]; other site 716540013802 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 716540013803 dimer interface [polypeptide binding]; other site 716540013804 phosphorylation site [posttranslational modification] 716540013805 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716540013806 ATP binding site [chemical binding]; other site 716540013807 Mg2+ binding site [ion binding]; other site 716540013808 G-X-G motif; other site 716540013809 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 716540013810 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716540013811 active site 716540013812 phosphorylation site [posttranslational modification] 716540013813 intermolecular recognition site; other site 716540013814 dimerization interface [polypeptide binding]; other site 716540013815 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 716540013816 putative binding surface; other site 716540013817 active site 716540013818 Signal peptide predicted for EAM_2708 by SignalP 2.0 HMM (Signal peptide probability 0.962) with cleavage site probability 0.451 between residues 33 and 34 716540013819 2 transmembrane helices predicted for EAM_2708 by TMHMM2.0 at aa 10-32 and 177-199 716540013820 HMMPfam hit to PF00672, HAMP domain, score 1.1e-13 716540013821 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 1.5e-26 716540013822 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 1.2e-40 716540013823 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.2e-36 716540013824 HMMPfam hit to PF01627, Hpt domain, score 1.1e-12 716540013825 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 716540013826 HMMPfam hit to PF02595, Glycerate kinase family, score 1.1e-218 716540013827 flavodoxin; Provisional; Region: PRK08105 716540013828 HMMPfam hit to PF00258, Flavodoxin, score 1.7e-27 716540013829 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 716540013830 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 716540013831 probable active site [active] 716540013832 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 2.6e-50 716540013833 PS01129 Rlu family of pseudouridine synthase signature. 716540013834 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 716540013835 HMMPfam hit to PF04287, Domain of unknown function, DUF446, score 3.4e-43 716540013836 SecY interacting protein Syd; Provisional; Region: PRK04968 716540013837 HMMPfam hit to PF07348, Syd protein, score 3.8e-102 716540013838 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 716540013839 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 716540013840 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 716540013841 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 716540013842 HMMPfam hit to PF01227, GTP cyclohydrolase I, score 3.1e-06 716540013843 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 716540013844 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 716540013845 HMMPfam hit to PF03641, Possible lysine decarboxylase, score 1.1e-52 716540013846 flap endonuclease-like protein; Provisional; Region: PRK09482 716540013847 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 716540013848 active site 716540013849 metal binding site 1 [ion binding]; metal-binding site 716540013850 putative 5' ssDNA interaction site; other site 716540013851 metal binding site 3; metal-binding site 716540013852 metal binding site 2 [ion binding]; metal-binding site 716540013853 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 716540013854 putative DNA binding site [nucleotide binding]; other site 716540013855 putative metal binding site [ion binding]; other site 716540013856 HMMPfam hit to PF02739, 5'-3' exonuclease, N-terminal resolvase-, score 6.2e-12 716540013857 HMMPfam hit to PF01367, 5'-3' exonuclease, C-terminal SAM fold, score 1.1e-23 716540013858 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 716540013859 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 716540013860 hypothetical protein; Provisional; Region: PRK10873 716540013861 4 transmembrane helices predicted for EAM_2718 by TMHMM2.0 at aa 7-29, 44-63, 70-92 and 97-119 716540013862 HMMPfam hit to PF04241, Protein of unknown function (DUF423), score 1.9e-44 716540013863 Signal peptide predicted for EAM_2718 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.551 between residues 34 and 35 716540013864 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 716540013865 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716540013866 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 716540013867 dimerization interface [polypeptide binding]; other site 716540013868 substrate binding pocket [chemical binding]; other site 716540013869 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.1e-43 716540013870 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1e-21 716540013871 PS00044 Bacterial regulatory proteins, lysR family signature. 716540013872 Predicted helix-turn-helix motif with score 1894.000, SD 5.64 at aa 21-42, sequence LSFTKAAEELFVTQAAVSHQIK 716540013873 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 716540013874 HMMPfam hit to PF06004, Bacterial protein of unknown function (DUF90, score 3e-36 716540013875 1 transmembrane helix predicted for EAM_2720 by TMHMM2.0 at aa 4-26 716540013876 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540013877 Signal peptide predicted for EAM_2720 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.418 between residues 19 and 20 716540013878 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 716540013879 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 716540013880 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 716540013881 catalytic residue [active] 716540013882 HMMPfam hit to PF00266, Aminotransferase class-V, score 3.4e-176 716540013883 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 716540013884 Fe-S metabolism associated domain; Region: SufE; cl00951 716540013885 HMMPfam hit to PF02657, Fe-S metabolism associated domain, score 2.5e-47 716540013886 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 716540013887 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 716540013888 putative ATP binding site [chemical binding]; other site 716540013889 putative substrate interface [chemical binding]; other site 716540013890 1 transmembrane helix predicted for EAM_2723 by TMHMM2.0 at aa 234-256 716540013891 HMMPfam hit to PF00899, ThiF family, score 1.3e-60 716540013892 murein transglycosylase A; Provisional; Region: mltA; PRK11162 716540013893 MltA specific insert domain; Region: MltA; pfam03562 716540013894 3D domain; Region: 3D; pfam06725 716540013895 HMMPfam hit to PF06725, 3D domain, score 5.3e-29 716540013896 HMMPfam hit to PF03562, MltA N-terminal domain, score 4.6e-99 716540013897 Signal peptide predicted for EAM_2724 by SignalP 2.0 HMM (Signal peptide probability 0.802) with cleavage site probability 0.625 between residues 23 and 24 716540013898 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540013899 AMIN domain; Region: AMIN; pfam11741 716540013900 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 716540013901 active site 716540013902 metal binding site [ion binding]; metal-binding site 716540013903 HMMPfam hit to PF01520, N-acetylmuramoyl-L-alanine amidase, score 7.3e-96 716540013904 Signal peptide predicted for EAM_2725 by SignalP 2.0 HMM (Signal peptide probability 0.696) with cleavage site probability 0.334 between residues 30 and 31 716540013905 N-acetylglutamate synthase; Validated; Region: PRK05279 716540013906 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 716540013907 putative feedback inhibition sensing region; other site 716540013908 putative nucleotide binding site [chemical binding]; other site 716540013909 putative substrate binding site [chemical binding]; other site 716540013910 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 716540013911 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716540013912 Coenzyme A binding pocket [chemical binding]; other site 716540013913 HMMPfam hit to PF00696, Amino acid kinase family, score 1.8e-30 716540013914 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1.8e-10 716540013915 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 716540013916 Signal peptide predicted for EAM_2727 by SignalP 2.0 HMM (Signal peptide probability 0.605) with cleavage site probability 0.310 between residues 27 and 28 716540013917 4 transmembrane helices predicted for EAM_2727 by TMHMM2.0 at aa 7-25, 75-97, 104-126 and 151-173 716540013918 HMMPfam hit to PF07274, Protein of unknown function (DUF1440), score 1.5e-82 716540013919 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 716540013920 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 716540013921 ATP binding site [chemical binding]; other site 716540013922 putative Mg++ binding site [ion binding]; other site 716540013923 Family description; Region: UvrD_C_2; pfam13538 716540013924 PS00017 ATP/GTP-binding site motif A (P-loop). 716540013925 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 716540013926 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 716540013927 HMMPfam hit to PF00580, UvrD/REP helicase, score 1.3e-115 716540013928 PS00017 ATP/GTP-binding site motif A (P-loop). 716540013929 PS00017 ATP/GTP-binding site motif A (P-loop). 716540013930 protease3; Provisional; Region: PRK15101 716540013931 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 716540013932 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 716540013933 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 716540013934 HMMPfam hit to PF05193, Peptidase M16 inactive domain, score 3.1e-12 716540013935 Predicted helix-turn-helix motif with score 973.000, SD 2.50 at aa 437-458, sequence DPQAIKARLDGMTPQNARIWFI 716540013936 HMMPfam hit to PF05193, Peptidase M16 inactive domain, score 5.5e-26 716540013937 HMMPfam hit to PF00675, Insulinase (Peptidase family M16), score 7.2e-45 716540013938 PS00143 Insulinase family, zinc-binding region signature. 716540013939 Signal peptide predicted for EAM_2730 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.691 between residues 22 and 23 716540013940 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 716540013941 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 716540013942 HMMPfam hit to PF04257, Exodeoxyribonuclease V, gamma subunit, score 0 716540013943 hypothetical protein; Provisional; Region: PRK10332 716540013944 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 716540013945 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 716540013946 HMMPfam hit to PF07963, Prokaryotic N-terminal methylation motif, score 0.00025 716540013947 Signal peptide predicted for EAM_2732 by SignalP 2.0 HMM (Signal peptide probability 0.766) with cleavage site probability 0.378 between residues 31 and 32 716540013948 PS00409 Prokaryotic N-terminal methylation site. 716540013949 1 transmembrane helix predicted for EAM_2732 by TMHMM2.0 at aa 10-27 716540013950 Protein of unknown function (DUF2509); Region: DUF2509; cl11672 716540013951 1 transmembrane helix predicted for EAM_2733 by TMHMM2.0 at aa 10-29 716540013952 Signal peptide predicted for EAM_2733 by SignalP 2.0 HMM (Signal peptide probability 0.627) with cleavage site probability 0.227 between residues 28 and 29 716540013953 hypothetical protein; Provisional; Region: PRK10557 716540013954 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 716540013955 1 transmembrane helix predicted for EAM_2734 by TMHMM2.0 at aa 10-32 716540013956 HMMPfam hit to PF07963, Prokaryotic N-terminal methylation motif, score 0.00011 716540013957 PS00409 Prokaryotic N-terminal methylation site. 716540013958 hypothetical protein; Provisional; Region: PRK10506 716540013959 Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963 716540013960 HMMPfam hit to PF07963, Prokaryotic N-terminal methylation motif, score 3.4e-06 716540013961 1 transmembrane helix predicted for EAM_2735 by TMHMM2.0 at aa 7-29 716540013962 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 716540013963 HMMPfam hit to PF01427, D-ala-D-ala dipeptidase, score 2.3e-80 716540013964 HMMPfam hit to PF02557, D-alanyl-D-alanine carboxypeptidase, score 5.3e-07 716540013965 thymidylate synthase; Reviewed; Region: thyA; PRK01827 716540013966 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 716540013967 dimerization interface [polypeptide binding]; other site 716540013968 active site 716540013969 HMMPfam hit to PF00303, Thymidylate synthase, score 2.1e-151 716540013970 PS00091 Thymidylate synthase active site. 716540013971 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 716540013972 HMMPfam hit to PF01790, Prolipoprotein diacylglyceryl transferase, score 5.4e-147 716540013973 7 transmembrane helices predicted for EAM_2738 by TMHMM2.0 at aa 15-37, 58-80, 95-117, 124-146, 199-218, 225-242 and 257-279 716540013974 PS01311 Prolipoprotein diacylglyceryl transferase signature. 716540013975 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 716540013976 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 716540013977 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 716540013978 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 716540013979 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 716540013980 HMMPfam hit to PF02896, PEP-utilising enzyme, TIM barrel doma, score 8.9e-145 716540013981 PS00742 PEP-utilizing enzymes signature 2. 716540013982 HMMPfam hit to PF00391, PEP-utilising enzyme, mobile domain, score 1.8e-22 716540013983 PS00370 PEP-utilizing enzymes phosphorylation site signature. 716540013984 HMMPfam hit to PF05524, PEP-utilising enzyme, N-terminal, score 7.9e-41 716540013985 HMMPfam hit to PF01590, GAF domain, score 1e-28 716540013986 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 716540013987 putative active site [active] 716540013988 Ap4A binding site [chemical binding]; other site 716540013989 nudix motif; other site 716540013990 putative metal binding site [ion binding]; other site 716540013991 HMMPfam hit to PF00293, NUDIX domain, score 6.9e-31 716540013992 PS00893 mutT domain signature. 716540013993 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 716540013994 putative DNA-binding cleft [nucleotide binding]; other site 716540013995 putative DNA clevage site; other site 716540013996 molecular lever; other site 716540013997 HMMPfam hit to PF02976, DNA mismatch repair enzyme MutH, score 5.3e-54 716540013998 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 716540013999 HMMPfam hit to PF03741, Integral membrane protein TerC family, score 2.9e-40 716540014000 5 transmembrane helices predicted for EAM_2742 by TMHMM2.0 at aa 15-37, 50-72, 143-165, 186-208 and 212-229 716540014001 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 716540014002 HMMPfam hit to PF06004, Bacterial protein of unknown function (DUF90, score 3.6e-31 716540014003 Signal peptide predicted for EAM_2743 by SignalP 2.0 HMM (Signal peptide probability 0.977) with cleavage site probability 0.391 between residues 24 and 25 716540014004 1 transmembrane helix predicted for EAM_2743 by TMHMM2.0 at aa 4-26 716540014005 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540014006 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 716540014007 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 716540014008 active site 716540014009 catalytic tetrad [active] 716540014010 HMMPfam hit to PF00248, Aldo/keto reductase family, score 8.2e-47 716540014011 PS00213 Lipocalin signature. 716540014012 lysophospholipid transporter LplT; Provisional; Region: PRK11195 716540014013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540014014 putative substrate translocation pore; other site 716540014015 10 transmembrane helices predicted for EAM_2745 by TMHMM2.0 at aa 19-41, 51-73, 94-116, 136-158, 165-187, 228-250, 257-279, 284-301, 308-330 and 371-393 716540014016 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 3.5e-10 716540014017 Signal peptide predicted for EAM_2745 by SignalP 2.0 HMM (Signal peptide probability 0.686) with cleavage site probability 0.656 between residues 29 and 30 716540014018 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 716540014019 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 716540014020 putative acyl-acceptor binding pocket; other site 716540014021 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 716540014022 acyl-activating enzyme (AAE) consensus motif; other site 716540014023 putative AMP binding site [chemical binding]; other site 716540014024 HMMPfam hit to PF00501, AMP-binding enzyme, score 7.4e-75 716540014025 PS00215 Mitochondrial energy transfer proteins signature. 716540014026 PS00455 AMP-binding domain signature. 716540014027 HMMPfam hit to PF01553, Acyltransferase, score 1.1e-21 716540014028 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 716540014029 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 716540014030 HMMPfam hit to PF00873, AcrB/AcrD/AcrF family, score 0 716540014031 10 transmembrane helices predicted for EAM_2749 by TMHMM2.0 at aa 7-29, 336-353, 358-380, 434-456, 463-485, 531-550, 859-881, 901-923, 960-977 and 992-1014 716540014032 PS00017 ATP/GTP-binding site motif A (P-loop). 716540014033 Signal peptide predicted for EAM_2749 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.591 between residues 28 and 29 716540014034 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 716540014035 Protein export membrane protein; Region: SecD_SecF; cl14618 716540014036 HMMPfam hit to PF00873, AcrB/AcrD/AcrF family, score 0 716540014037 10 transmembrane helices predicted for EAM_2750 by TMHMM2.0 at aa 7-29, 334-353, 360-382, 429-451, 463-485, 529-548, 899-921, 941-963, 995-1017 and 1032-1054 716540014038 Signal peptide predicted for EAM_2750 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.633 between residues 36 and 37 716540014039 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 716540014040 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 716540014041 HlyD family secretion protein; Region: HlyD_3; pfam13437 716540014042 PS00398 Site-specific recombinases signature 2. 716540014043 HMMPfam hit to PF00529, HlyD family secretion protein, score 6.2e-26 716540014044 HMMPfam hit to PF00364, Biotin-requiring enzyme, score 0.00063 716540014045 1 transmembrane helix predicted for EAM_2751 by TMHMM2.0 at aa 13-35 716540014046 Signal peptide predicted for EAM_2751 by SignalP 2.0 HMM (Signal peptide probability 0.990) with cleavage site probability 0.329 between residues 25 and 26 716540014047 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 716540014048 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 716540014049 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 716540014050 HMMPfam hit to PF00905, Penicillin binding protein transpeptid, score 1.5e-94 716540014051 HMMPfam hit to PF03717, Penicillin-binding Protein dimerisatio, score 7.4e-39 716540014052 Signal peptide predicted for EAM_2752 by SignalP 2.0 HMM (Signal peptide probability 0.922) with cleavage site probability 0.793 between residues 41 and 42 716540014053 1 transmembrane helix predicted for EAM_2752 by TMHMM2.0 at aa 19-41 716540014054 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 716540014055 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 716540014056 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 716540014057 Signal peptide predicted for EAM_2753 by SignalP 2.0 HMM (Signal peptide probability 0.928) with cleavage site probability 0.814 between residues 30 and 31 716540014058 HMMPfam hit to PF08479, POTRA domain, ShlB-type, score 9.3e-32 716540014059 HMMPfam hit to PF03865, Haemolysin secretion/activation protein ShlB, score 1e-10 716540014060 PS00287 Cysteine proteases inhibitors signature. 716540014061 haemagglutination activity domain; Region: Haemagg_act; pfam05860 716540014062 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 716540014063 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 716540014064 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 716540014065 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 716540014066 Signal peptide predicted for EAM_2754 by SignalP 2.0 HMM (Signal peptide probability 0.826) with cleavage site probability 0.494 between residues 57 and 58 716540014067 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540014068 HMMPfam hit to PF05860, haemagglutination activity domain, score 4.4e-48 716540014069 HMMPfam hit to PF05594, Haemagluttinin repeat, score 2e-08 716540014070 HMMPfam hit to PF05594, Haemagluttinin repeat, score 3.1 716540014071 HMMPfam hit to PF05594, Haemagluttinin repeat, score 0.15 716540014072 HMMPfam hit to PF05594, Haemagluttinin repeat, score 0.00037 716540014073 HMMPfam hit to PF05594, Haemagluttinin repeat, score 2.9 716540014074 HMMPfam hit to PF05594, Haemagluttinin repeat, score 0.0076 716540014075 HMMPfam hit to PF05594, Haemagluttinin repeat, score 0.00092 716540014076 PS00017 ATP/GTP-binding site motif A (P-loop). 716540014077 HMMPfam hit to PF05594, Haemagluttinin repeat, score 2.1 716540014078 HMMPfam hit to PF05594, Haemagluttinin repeat, score 6.5e-06 716540014079 HMMPfam hit to PF05594, Haemagluttinin repeat, score 1.8 716540014080 HMMPfam hit to PF05594, Haemagluttinin repeat, score 1 716540014081 HMMPfam hit to PF05594, Haemagluttinin repeat, score 3.3 716540014082 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 716540014083 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 716540014084 Signal peptide predicted for EAM_2758 by SignalP 2.0 HMM (Signal peptide probability 0.974) with cleavage site probability 0.759 between residues 33 and 34 716540014085 PS00012 Phosphopantetheine attachment site. 716540014086 2 transmembrane helices predicted for EAM_2758 by TMHMM2.0 at aa 12-37 and 52-74 716540014087 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540014088 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 716540014089 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 716540014090 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 716540014091 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 716540014092 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 716540014093 Cytotoxic; Region: Cytotoxic; pfam09000 716540014094 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 716540014095 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 716540014096 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 716540014097 HMMPfam hit to PF06316, Enterobacterial Ail/Lom protein, score 2.8e-29 716540014098 PS00430 TonB-dependent receptor proteins signature 1. 716540014099 Signal peptide predicted for EAM_2768 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.554 between residues 21 and 22 716540014100 PS00694 Enterobacterial virulence outer membrane protein signature 1. 716540014101 PS00017 ATP/GTP-binding site motif A (P-loop). 716540014102 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 716540014103 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 716540014104 molybdopterin cofactor binding site [chemical binding]; other site 716540014105 substrate binding site [chemical binding]; other site 716540014106 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 716540014107 molybdopterin cofactor binding site; other site 716540014108 HMMPfam hit to PF01568, Molydopterin dinucleotide binding dom, score 1.7e-31 716540014109 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 3.6e-73 716540014110 PS00490 Prokaryotic molybdopterin oxidoreductases signature 2. 716540014111 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 716540014112 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 716540014113 DNA binding site [nucleotide binding] 716540014114 domain linker motif; other site 716540014115 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 716540014116 dimerization interface (closed form) [polypeptide binding]; other site 716540014117 ligand binding site [chemical binding]; other site 716540014118 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 2.8e-14 716540014119 Predicted helix-turn-helix motif with score 2178.000, SD 6.60 at aa 2-23, sequence ATIKDVARLAGVSVATVSRVIN 716540014120 PS00356 Bacterial regulatory proteins, lacI family signature. 716540014121 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 6e-18 716540014122 diaminopimelate decarboxylase; Provisional; Region: PRK11165 716540014123 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 716540014124 active site 716540014125 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 716540014126 substrate binding site [chemical binding]; other site 716540014127 catalytic residues [active] 716540014128 dimer interface [polypeptide binding]; other site 716540014129 HMMPfam hit to PF00278, Pyridoxal-dependent decarboxylase, C-, score 9.9e-39 716540014130 HMMPfam hit to PF02784, Pyridoxal-dependent decarboxylase, py, score 3.8e-72 716540014131 PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2. 716540014132 PS00878 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P attachment site. 716540014133 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 716540014134 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716540014135 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 716540014136 dimerization interface [polypeptide binding]; other site 716540014137 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.1e-19 716540014138 Predicted helix-turn-helix motif with score 1894.000, SD 5.64 at aa 19-40, sequence GNLTEAAALLHTSQPTVSRELA 716540014139 PS00044 Bacterial regulatory proteins, lysR family signature. 716540014140 HMMPfam hit to PF03466, LysR substrate binding domain, score 3.5e-48 716540014141 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540014142 Major Facilitator Superfamily; Region: MFS_1; pfam07690 716540014143 putative substrate translocation pore; other site 716540014144 12 transmembrane helices predicted for EAM_2773 by TMHMM2.0 at aa 5-26, 41-63, 70-89, 99-121, 128-150, 154-176, 201-223, 238-256, 263-285, 295-314, 327-349 and 353-375 716540014145 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 4e-45 716540014146 Signal peptide predicted for EAM_2773 by SignalP 2.0 HMM (Signal peptide probability 0.957) with cleavage site probability 0.594 between residues 14 and 15 716540014147 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 716540014148 1 transmembrane helix predicted for EAM_2774 by TMHMM2.0 at aa 15-37 716540014149 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540014150 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 716540014151 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 716540014152 dimer interface [polypeptide binding]; other site 716540014153 putative anticodon binding site; other site 716540014154 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 716540014155 motif 1; other site 716540014156 active site 716540014157 motif 2; other site 716540014158 motif 3; other site 716540014159 HMMPfam hit to PF00152, tRNA synthetases class II (D, K and N), score 6.7e-135 716540014160 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 716540014161 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 716540014162 HMMPfam hit to PF01336, OB-fold nucleic acid binding domain, score 1.2e-20 716540014163 peptide chain release factor 2; Validated; Region: prfB; PRK00578 716540014164 This domain is found in peptide chain release factors; Region: PCRF; smart00937 716540014165 RF-1 domain; Region: RF-1; pfam00472 716540014166 HMMPfam hit to PF00472, Peptidyl-tRNA hydrolase domain, score 2e-72 716540014167 PS00745 Prokaryotic-type class I peptide chain release factors signature. 716540014168 HMMPfam hit to PF03462, PCRF domain, score 1.7e-58 716540014169 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 716540014170 DHH family; Region: DHH; pfam01368 716540014171 DHHA1 domain; Region: DHHA1; pfam02272 716540014172 HMMPfam hit to PF02272, DHHA1 domain, score 1.4e-15 716540014173 HMMPfam hit to PF01368, DHH family, score 1.3e-49 716540014174 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 716540014175 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 716540014176 dimerization domain [polypeptide binding]; other site 716540014177 dimer interface [polypeptide binding]; other site 716540014178 catalytic residues [active] 716540014179 PS00194 Thioredoxin family active site. 716540014180 PS00190 Cytochrome c family heme-binding site signature. 716540014181 Signal peptide predicted for EAM_2778 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 21 and 22 716540014182 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 716540014183 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 716540014184 active site 716540014185 Int/Topo IB signature motif; other site 716540014186 HMMPfam hit to PF00589, Phage integrase family, score 4.7e-70 716540014187 HMMPfam hit to PF02899, Phage integrase, N-terminal SAM-like, score 1.9e-29 716540014188 Pectate lyase; Region: Pec_lyase_C; cl01593 716540014189 HMMPfam hit to PF00544, Pectate lyase, score 5.6e-36 716540014190 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 716540014191 EamA-like transporter family; Region: EamA; pfam00892 716540014192 Signal peptide predicted for EAM_2781 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.978 between residues 25 and 26 716540014193 10 transmembrane helices predicted for EAM_2781 by TMHMM2.0 at aa 2-24, 34-51, 64-86, 91-113, 120-142, 157-174, 195-217, 232-252, 259-281 and 286-308 716540014194 flavodoxin FldB; Provisional; Region: PRK12359 716540014195 HMMPfam hit to PF00258, Flavodoxin, score 2.4e-32 716540014196 PS00201 Flavodoxin signature. 716540014197 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 716540014198 HMMPfam hit to PF07254, Protein of unknown function (DUF1434), score 8.1e-17 716540014199 1 transmembrane helix predicted for EAM_2783 by TMHMM2.0 at aa 4-26 716540014200 hypothetical protein; Provisional; Region: PRK10878 716540014201 HMMPfam hit to PF03937, TPR repeat region, score 1.2e-39 716540014202 putative global regulator; Reviewed; Region: PRK09559 716540014203 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 716540014204 HMMPfam hit to PF01571, Glycine cleavage T-protein (aminomethyl tran, score 4.3e-05 716540014205 hemolysin; Provisional; Region: PRK15087 716540014206 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 716540014207 7 transmembrane helices predicted for EAM_2786 by TMHMM2.0 at aa 21-38, 48-70, 90-107, 111-133, 138-160, 165-187 and 194-216 716540014208 HMMPfam hit to PF03006, Haemolysin-III related, score 3.4e-63 716540014209 HD domain; Region: HD_3; pfam13023 716540014210 short chain dehydrogenase; Provisional; Region: PRK06123 716540014211 classical (c) SDRs; Region: SDR_c; cd05233 716540014212 NAD(P) binding site [chemical binding]; other site 716540014213 active site 716540014214 HMMPfam hit to PF00106, short chain dehydrogenase, score 2.9e-10 716540014215 PS00061 Short-chain dehydrogenases/reductases family signature. 716540014216 glycine dehydrogenase; Provisional; Region: PRK05367 716540014217 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 716540014218 tetramer interface [polypeptide binding]; other site 716540014219 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716540014220 catalytic residue [active] 716540014221 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 716540014222 tetramer interface [polypeptide binding]; other site 716540014223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716540014224 catalytic residue [active] 716540014225 HMMPfam hit to PF02347, Glycine cleavage system P-protein, score 9.6e-271 716540014226 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 716540014227 lipoyl attachment site [posttranslational modification]; other site 716540014228 HMMPfam hit to PF01597, Glycine cleavage H-protein, score 1.3e-58 716540014229 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 716540014230 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 716540014231 HMMPfam hit to PF01571, Glycine cleavage T-protein (aminomethyl tran, score 1.1e-135 716540014232 oxidoreductase; Provisional; Region: PRK08013 716540014233 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 716540014234 HMMPfam hit to PF01494, FAD binding domain, score 8.7e-10 716540014235 PS01304 ubiH/COQ6 monooxygenase family signature. 716540014236 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 7.3e-05 716540014237 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540014238 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 716540014239 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 716540014240 HMMPfam hit to PF04820, Tryptophan halogenase, score 0.0096 716540014241 HMMPfam hit to PF01494, FAD binding domain, score 4.3e-08 716540014242 PS01304 ubiH/COQ6 monooxygenase family signature. 716540014243 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 0.0013 716540014244 Signal peptide predicted for EAM_2793 by SignalP 2.0 HMM (Signal peptide probability 0.953) with cleavage site probability 0.686 between residues 25 and 26 716540014245 proline aminopeptidase P II; Provisional; Region: PRK10879 716540014246 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 716540014247 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 716540014248 active site 716540014249 HMMPfam hit to PF00557, metallopeptidase family M24, score 1.2e-108 716540014250 PS00491 Aminopeptidase P and proline dipeptidase signature. 716540014251 HMMPfam hit to PF05195, Aminopeptidase P, N-terminal domain, score 1.8e-54 716540014252 Signal peptide predicted for EAM_2794 by SignalP 2.0 HMM (Signal peptide probability 0.945) with cleavage site probability 0.881 between residues 27 and 28 716540014253 hypothetical protein; Reviewed; Region: PRK01736 716540014254 HMMPfam hit to PF03695, Uncharacterised protein family (UPF0149), score 3.9e-97 716540014255 Z-ring-associated protein; Provisional; Region: PRK10972 716540014256 HMMPfam hit to PF05164, Cell division protein ZapA, score 6e-34 716540014257 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 716540014258 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 716540014259 HMMPfam hit to PF01812, 5-formyltetrahydrofolate cyclo-ligase, score 1.1e-53 716540014260 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 716540014261 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 716540014262 ligand binding site [chemical binding]; other site 716540014263 NAD binding site [chemical binding]; other site 716540014264 tetramer interface [polypeptide binding]; other site 716540014265 catalytic site [active] 716540014266 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 716540014267 L-serine binding site [chemical binding]; other site 716540014268 ACT domain interface; other site 716540014269 HMMPfam hit to PF01842, ACT domain, score 7.4e-11 716540014270 HMMPfam hit to PF00389, D-isomer specific 2-hydroxyacid dehydrog, score 3.4e-34 716540014271 HMMPfam hit to PF02826, D-isomer specific 2-hydroxyacid dehydrog, score 2e-66 716540014272 PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 716540014273 PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. 716540014274 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 716540014275 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 716540014276 tetramer (dimer of dimers) interface [polypeptide binding]; other site 716540014277 active site 716540014278 dimer interface [polypeptide binding]; other site 716540014279 HMMPfam hit to PF06026, Ribose 5-phosphate isomerase A (phosph, score 2.7e-92 716540014280 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 716540014281 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716540014282 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 716540014283 putative dimerization interface [polypeptide binding]; other site 716540014284 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 3.9e-18 716540014285 PS00044 Bacterial regulatory proteins, lysR family signature. 716540014286 HMMPfam hit to PF03466, LysR substrate binding domain, score 3.2e-10 716540014287 Uncharacterized conserved protein [Function unknown]; Region: COG2968 716540014288 oxidative stress defense protein; Provisional; Region: PRK11087 716540014289 HMMPfam hit to PF04402, Protein of unknown function (DUF541), score 2.7e-78 716540014290 Signal peptide predicted for EAM_2801 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.968 between residues 31 and 32 716540014291 LysE type translocator; Region: LysE; cl00565 716540014292 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 716540014293 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 716540014294 inhibitor-cofactor binding pocket; inhibition site 716540014295 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716540014296 catalytic residue [active] 716540014297 HMMPfam hit to PF01041, DegT/DnrJ/EryC1/StrS aminotransferase, score 1.7e-68 716540014298 HMMPfam hit to PF01212, Beta-eliminating lyase, score 0.0034 716540014299 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 716540014300 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 716540014301 HMMPfam hit to PF05116, Sucrose-6F-phosphate phosphohydrolase, score 3.2e-08 716540014302 HMMPfam hit to PF08282, haloacid dehalogenase-like hydrolase, score 4.7e-05 716540014303 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 716540014304 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 716540014305 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 716540014306 HMMPfam hit to PF01408, Oxidoreductase family, NAD-binding Ros, score 2.1e-09 716540014307 HMMPfam hit to PF02894, Oxidoreductase family, C-terminal alph, score 0.07 716540014308 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 716540014309 Uncharacterized conserved protein [Function unknown]; Region: COG4095 716540014310 Signal peptide predicted for EAM_2806 by SignalP 2.0 HMM (Signal peptide probability 0.957) with cleavage site probability 0.778 between residues 20 and 21 716540014311 3 transmembrane helices predicted for EAM_2806 by TMHMM2.0 at aa 4-21, 34-56 and 60-82 716540014312 HMMPfam hit to PF03083, MtN3/saliva family, score 0.00015 716540014313 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 716540014314 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 716540014315 HMMPfam hit to PF00743, Flavin-binding monooxygenase-like, score 4.6e-10 716540014316 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 716540014317 putative trimer interface [polypeptide binding]; other site 716540014318 putative CoA binding site [chemical binding]; other site 716540014319 PS00294 Prenyl group binding site (CAAX box). 716540014320 PS00022 EGF-like domain signature 1. 716540014321 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 22 716540014322 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.16 716540014323 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.54 716540014324 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 15 716540014325 LysE type translocator; Region: LysE; cl00565 716540014326 6 transmembrane helices predicted for EAM_2809 by TMHMM2.0 at aa 5-27, 40-62, 66-88, 109-127, 147-169 and 182-204 716540014327 HMMPfam hit to PF01810, LysE type translocator, score 1.8e-59 716540014328 Signal peptide predicted for EAM_2809 by SignalP 2.0 HMM (Signal peptide probability 0.933) with cleavage site probability 0.888 between residues 26 and 27 716540014329 mechanosensitive channel MscS; Provisional; Region: PRK10334 716540014330 Mechanosensitive ion channel; Region: MS_channel; pfam00924 716540014331 HMMPfam hit to PF00924, Mechanosensitive ion channel, score 4.1e-72 716540014332 PS01246 Uncharacterized protein family UPF0003 signature. 716540014333 3 transmembrane helices predicted for EAM_2810 by TMHMM2.0 at aa 23-45, 65-87 and 94-116 716540014334 HMMPfam hit to PF05552, Conserved TM helix, score 1.4e-14 716540014335 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 716540014336 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 716540014337 active site 716540014338 intersubunit interface [polypeptide binding]; other site 716540014339 zinc binding site [ion binding]; other site 716540014340 Na+ binding site [ion binding]; other site 716540014341 HMMPfam hit to PF01116, Fructose-bisphosphate aldolase class-II, score 1.9e-207 716540014342 PS00806 Fructose-bisphosphate aldolase class-II signature 2. 716540014343 PS00602 Fructose-bisphosphate aldolase class-II signature 1. 716540014344 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 716540014345 Phosphoglycerate kinase; Region: PGK; pfam00162 716540014346 substrate binding site [chemical binding]; other site 716540014347 hinge regions; other site 716540014348 ADP binding site [chemical binding]; other site 716540014349 catalytic site [active] 716540014350 HMMPfam hit to PF00162, Phosphoglycerate kinase, score 2e-123 716540014351 PS00111 Phosphoglycerate kinase signature. 716540014352 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 716540014353 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 716540014354 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 716540014355 HMMPfam hit to PF02800, Glyceraldehyde 3-phosphate dehydrogenase, C-, score 4.7e-68 716540014356 PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site. 716540014357 HMMPfam hit to PF00044, Glyceraldehyde 3-phosphate dehydrogenase, NA, score 1e-75 716540014358 transketolase; Reviewed; Region: PRK12753 716540014359 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 716540014360 TPP-binding site [chemical binding]; other site 716540014361 dimer interface [polypeptide binding]; other site 716540014362 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 716540014363 PYR/PP interface [polypeptide binding]; other site 716540014364 dimer interface [polypeptide binding]; other site 716540014365 TPP binding site [chemical binding]; other site 716540014366 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 716540014367 HMMPfam hit to PF02780, Transketolase, C-terminal domain, score 1.8e-12 716540014368 HMMPfam hit to PF02779, Transketolase, pyridine binding domai, score 4.1e-62 716540014369 PS00802 Transketolase signature 2. 716540014370 HMMPfam hit to PF00456, Transketolase, thiamine diphosphate b, score 1.3e-242 716540014371 PS00801 Transketolase signature 1. 716540014372 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 716540014373 Signal peptide predicted for EAM_2815 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.355 between residues 28 and 29 716540014374 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540014375 HMMPfam hit to PF01435, Peptidase family M48, score 7.6e-22 716540014376 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 716540014377 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 716540014378 dimer interface [polypeptide binding]; other site 716540014379 ligand binding site [chemical binding]; other site 716540014380 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 716540014381 dimerization interface [polypeptide binding]; other site 716540014382 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 716540014383 dimer interface [polypeptide binding]; other site 716540014384 putative CheW interface [polypeptide binding]; other site 716540014385 Signal peptide predicted for EAM_2816 by SignalP 2.0 HMM (Signal peptide probability 0.926) with cleavage site probability 0.579 between residues 33 and 34 716540014386 2 transmembrane helices predicted for EAM_2816 by TMHMM2.0 at aa 10-32 and 194-216 716540014387 HMMPfam hit to PF00672, HAMP domain, score 1.7e-13 716540014388 PS00538 Bacterial chemotaxis sensory transducers signature. 716540014389 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 3.9e-115 716540014390 Signal peptide predicted for EAM_2817 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.989 between residues 20 and 21 716540014391 Signal peptide predicted for EAM_2818 by SignalP 2.0 HMM (Signal peptide probability 0.754) with cleavage site probability 0.715 between residues 26 and 27 716540014392 Signal peptide predicted for EAM_2820 by SignalP 2.0 HMM (Signal peptide probability 0.897) with cleavage site probability 0.521 between residues 20 and 21 716540014393 Signal peptide predicted for EAM_2821 by SignalP 2.0 HMM (Signal peptide probability 0.681) with cleavage site probability 0.426 between residues 20 and 21 716540014394 4 transmembrane helices predicted for EAM_2821 by TMHMM2.0 at aa 2-19, 29-46, 51-68 and 83-105 716540014395 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 716540014396 putative active site [active] 716540014397 Signal peptide predicted for EAM_2822 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.833 between residues 22 and 23 716540014398 HMMPfam hit to PF03412, Peptidase C39 family, score 2.3e-06 716540014399 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 716540014400 agmatinase; Region: agmatinase; TIGR01230 716540014401 oligomer interface [polypeptide binding]; other site 716540014402 putative active site [active] 716540014403 Mn binding site [ion binding]; other site 716540014404 HMMPfam hit to PF00491, Arginase family, score 1.7e-109 716540014405 PS01053 Arginase family signature 3. 716540014406 PS00148 Arginase family signature 2. 716540014407 PS00147 Arginase family signature 1. 716540014408 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 716540014409 HMMPfam hit to PF06078, Bacterial protein of unknown function (DUF93, score 5.4e-20 716540014410 arginine decarboxylase; Provisional; Region: PRK05354 716540014411 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 716540014412 dimer interface [polypeptide binding]; other site 716540014413 active site 716540014414 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 716540014415 catalytic residues [active] 716540014416 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 716540014417 HMMPfam hit to PF00278, Pyridoxal-dependent decarboxylase, C-, score 5.3e-42 716540014418 HMMPfam hit to PF02784, Pyridoxal-dependent decarboxylase, py, score 1.1e-111 716540014419 PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2. 716540014420 PS00878 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P attachment site. 716540014421 S-adenosylmethionine synthetase; Validated; Region: PRK05250 716540014422 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 716540014423 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 716540014424 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 716540014425 HMMPfam hit to PF00438, S-adenosylmethionine synthetase, N-te, score 6.3e-63 716540014426 HMMPfam hit to PF02772, S-adenosylmethionine synthetase, cent, score 1.3e-84 716540014427 PS00376 S-adenosylmethionine synthetase signature 1. 716540014428 HMMPfam hit to PF02773, S-adenosylmethionine synthetase, C-te, score 1e-91 716540014429 PS00377 S-adenosylmethionine synthetase signature 2. 716540014430 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 716540014431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540014432 putative substrate translocation pore; other site 716540014433 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540014434 Signal peptide predicted for EAM_2827 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.531 between residues 31 and 32 716540014435 HMMPfam hit to PF00083, Sugar (and other) transporter, score 3.4e-176 716540014436 12 transmembrane helices predicted for EAM_2827 by TMHMM2.0 at aa 21-43, 58-80, 85-104, 109-131, 144-161, 171-193, 253-275, 290-312, 319-341, 351-373, 386-408 and 418-437 716540014437 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 3.8e-45 716540014438 PS00217 Sugar transport proteins signature 2. 716540014439 PS00216 Sugar transport proteins signature 1. 716540014440 hypothetical protein; Provisional; Region: PRK04860 716540014441 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 716540014442 HMMPfam hit to PF03926, metallopeptidase (SprT family), score 6.6e-73 716540014443 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 716540014444 DNA-specific endonuclease I; Provisional; Region: PRK15137 716540014445 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 716540014446 Signal peptide predicted for EAM_2829 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.954 between residues 22 and 23 716540014447 HMMPfam hit to PF04231, Endonuclease I, score 2.6e-126 716540014448 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 716540014449 RNA methyltransferase, RsmE family; Region: TIGR00046 716540014450 HMMPfam hit to PF04452, Protein of unknown function (DUF558), score 8e-101 716540014451 PS00215 Mitochondrial energy transfer proteins signature. 716540014452 glutathione synthetase; Provisional; Region: PRK05246 716540014453 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 716540014454 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 716540014455 HMMPfam hit to PF02951, Prokaryotic glutathione synthetase, N-termi, score 5.7e-69 716540014456 HMMPfam hit to PF08443, RimK-like ATP-grasp domain, score 0.00014 716540014457 HMMPfam hit to PF02955, Prokaryotic glutathione synthetase, ATP-gra, score 5.8e-129 716540014458 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 716540014459 hypothetical protein; Validated; Region: PRK00228 716540014460 HMMPfam hit to PF02622, Uncharacterized ACR, COG1678, score 2e-99 716540014461 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 716540014462 HMMPfam hit to PF03652, Uncharacterised protein family (UPF0081), score 7.8e-70 716540014463 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 716540014464 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 716540014465 catalytic triad [active] 716540014466 Signal peptide predicted for EAM_2834 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.959 between residues 27 and 28 716540014467 2 transmembrane helices predicted for EAM_2834 by TMHMM2.0 at aa 7-29 and 61-83 716540014468 HMMPfam hit to PF08534, Redoxin, score 3.1e-14 716540014469 HMMPfam hit to PF00578, AhpC/TSA family, score 1.6e-08 716540014470 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 716540014471 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 716540014472 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 716540014473 DsbD alpha interface [polypeptide binding]; other site 716540014474 catalytic residues [active] 716540014475 Signal peptide predicted for EAM_2835 by SignalP 2.0 HMM (Signal peptide probability 0.690) with cleavage site probability 0.426 between residues 28 and 29 716540014476 8 transmembrane helices predicted for EAM_2835 by TMHMM2.0 at aa 5-27, 47-69, 84-106, 127-149, 159-181, 194-216, 221-243 and 256-275 716540014477 HMMPfam hit to PF02683, Cytochrome C biogenesis protein transmembran, score 5.4e-05 716540014478 RNA polymerase sigma factor; Provisional; Region: PRK12512 716540014479 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 716540014480 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 716540014481 DNA binding residues [nucleotide binding] 716540014482 HMMPfam hit to PF04542, Sigma-70 region, score 1.3e-11 716540014483 HMMPfam hit to PF08281, Sigma-70, region, score 6.3e-11 716540014484 HMMPfam hit to PF04545, Sigma-70, region, score 1.2e-10 716540014485 5 transmembrane helices predicted for EAM_2837 by TMHMM2.0 at aa 28-50, 62-79, 94-116, 128-150 and 155-177 716540014486 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 716540014487 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 716540014488 Walker A motif; other site 716540014489 ATP binding site [chemical binding]; other site 716540014490 Walker B motif; other site 716540014491 HMMPfam hit to PF00437, Type II/IV secretion system protein, score 7.1e-19 716540014492 PS00662 Bacterial type II secretion system protein E signature. 716540014493 PS00017 ATP/GTP-binding site motif A (P-loop). 716540014494 PS00449 ATP synthase a subunit signature. 716540014495 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 716540014496 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 716540014497 catalytic residue [active] 716540014498 HMMPfam hit to PF01168, Alanine racemase, N-terminal domain, score 6e-34 716540014499 PS01211 Uncharacterized protein family UPF0001 signature. 716540014500 YGGT family; Region: YGGT; pfam02325 716540014501 YGGT family; Region: YGGT; pfam02325 716540014502 HMMPfam hit to PF02325, YGGT family, score 8.3e-19 716540014503 4 transmembrane helices predicted for EAM_2840 by TMHMM2.0 at aa 2-24, 63-85, 90-112 and 148-170 716540014504 HMMPfam hit to PF02325, YGGT family, score 7.4e-20 716540014505 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 716540014506 active site 716540014507 dimerization interface [polypeptide binding]; other site 716540014508 HMMPfam hit to PF01725, Ham1 family, score 2e-94 716540014509 HemN family oxidoreductase; Provisional; Region: PRK05660 716540014510 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 716540014511 FeS/SAM binding site; other site 716540014512 HemN C-terminal domain; Region: HemN_C; pfam06969 716540014513 HMMPfam hit to PF04055, Radical SAM superfamily, score 5.6e-25 716540014514 HMMPfam hit to PF06969, HemN C-terminal region, score 2.8e-19 716540014515 hypothetical protein; Provisional; Region: PRK10626 716540014516 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 716540014517 Signal peptide predicted for EAM_2843 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.927 between residues 20 and 21 716540014518 hypothetical protein; Provisional; Region: PRK11702 716540014519 HMMPfam hit to PF04320, Protein with unknown function (DUF469), score 1.6e-73 716540014520 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 716540014521 HMMPfam hit to PF02390, methyltransferase, score 4.2e-95 716540014522 adenine DNA glycosylase; Provisional; Region: PRK10880 716540014523 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 716540014524 minor groove reading motif; other site 716540014525 helix-hairpin-helix signature motif; other site 716540014526 substrate binding pocket [chemical binding]; other site 716540014527 active site 716540014528 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 716540014529 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 716540014530 DNA binding and oxoG recognition site [nucleotide binding] 716540014531 HMMPfam hit to PF00730, HhH-GPD superfamily base excision DNA repair, score 2e-20 716540014532 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 6.9e-05 716540014533 PS01155 Endonuclease III family signature. 716540014534 PS00764 Endonuclease III iron-sulfur binding region signature. 716540014535 oxidative damage protection protein; Provisional; Region: PRK05408 716540014536 HMMPfam hit to PF04362, Bacterial Fe(2+) trafficking, score 5e-57 716540014537 murein transglycosylase C; Provisional; Region: mltC; PRK11671 716540014538 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 716540014539 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 716540014540 N-acetyl-D-glucosamine binding site [chemical binding]; other site 716540014541 catalytic residue [active] 716540014542 Signal peptide predicted for EAM_2848 by SignalP 2.0 HMM (Signal peptide probability 0.807) with cleavage site probability 0.655 between residues 22 and 23 716540014543 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540014544 HMMPfam hit to PF01464, Transglycosylase SLT domain, score 6e-45 716540014545 PS00922 Prokaryotic transglycosylases signature. 716540014546 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 716540014547 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 716540014548 HMMPfam hit to PF02796, Helix-turn-helix domain of resolvase, score 0.0041 716540014549 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 2.8e-06 716540014550 ornithine decarboxylase; Provisional; Region: PRK13578 716540014551 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 716540014552 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 716540014553 homodimer interface [polypeptide binding]; other site 716540014554 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716540014555 catalytic residue [active] 716540014556 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 716540014557 HMMPfam hit to PF03711, Orn/Lys/Arg decarboxylase, C-terminal doma, score 7.9e-85 716540014558 HMMPfam hit to PF01276, Orn/Lys/Arg decarboxylase, major domain, score 0 716540014559 PS00703 Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site. 716540014560 HMMPfam hit to PF03709, Orn/Lys/Arg decarboxylase, N-terminal doma, score 2.4e-36 716540014561 1 transmembrane helix predicted for EAM_2851 by TMHMM2.0 at aa 7-26 716540014562 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 716540014563 active site 716540014564 catalytic residues [active] 716540014565 DNA binding site [nucleotide binding] 716540014566 Int/Topo IB signature motif; other site 716540014567 HMMPfam hit to PF00589, Phage integrase family, score 1.7e-14 716540014568 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 716540014569 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 716540014570 HMMPfam hit to PF07515, Protein of unknown function (DUF1528), score 2.7e-09 716540014571 3 transmembrane helices predicted for EAM_2853 by TMHMM2.0 at aa 13-35, 55-74 and 94-111 716540014572 Signal peptide predicted for EAM_2853 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.900 between residues 36 and 37 716540014573 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 716540014574 Signal peptide predicted for EAM_2854 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.985 between residues 21 and 22 716540014575 integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756 716540014576 HMMPfam hit to PF07513, Protein of unknown function (DUF1527), score 2.4e-151 716540014577 Signal peptide predicted for EAM_2855 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.602 between residues 35 and 36 716540014578 Protein of unknown function (DUF1525); Region: DUF1525; pfam07511 716540014579 HMMPfam hit to PF07511, Protein of unknown function (DUF1525), score 2.8e-40 716540014580 Signal peptide predicted for EAM_2856 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.991 between residues 19 and 20 716540014581 GIY-YIG catalytic domain; Region: GIY-YIG; pfam01541 716540014582 GIY-YIG motif/motif A; other site 716540014583 active site 716540014584 catalytic site [active] 716540014585 PS00018 EF-hand calcium-binding domain. 716540014586 2 transmembrane helices predicted for EAM_2862 by TMHMM2.0 at aa 20-42 and 49-67 716540014587 PAAR motif; Region: PAAR_motif; pfam05488 716540014588 HMMPfam hit to PF05488, PAAR motif, score 1.9e-06 716540014589 HMMPfam hit to PF05488, PAAR motif, score 0.0001 716540014590 Signal peptide predicted for EAM_2864 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.894 between residues 23 and 24 716540014591 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 716540014592 catalytic residue [active] 716540014593 HMMPfam hit to PF00182, Chitinase class I, score 0.004 716540014594 HMMPfam hit to PF00036, EF hand, score 0.012 716540014595 PS00018 EF-hand calcium-binding domain. 716540014596 PS00063 Aldo/keto reductase family active site signature. 716540014597 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 716540014598 Signal peptide predicted for EAM_2866 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 21 and 22 716540014599 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 716540014600 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 716540014601 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 716540014602 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 716540014603 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 716540014604 HMMPfam hit to PF07724, ATPase family associated with various cell, score 2.1e-16 716540014605 HMMPfam hit to PF05930, Prophage CP4-57 regulatory protein (AlpA), score 0.00053 716540014606 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716540014607 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716540014608 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix protei, score 4.4e-14 716540014609 type III secretion system 3 (Hrp pathogenicity island) 716540014610 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 716540014611 HMMPfam hit to PF06704, DspF/AvrF protein, score 2e-112 716540014612 HMMPfam hit to PF05932, Tir chaperone protein (CesT), score 0.00012 716540014613 Pathogenicity factor; Region: AvrE; pfam11725 716540014614 Pectate lyase; Region: Pectate_lyase; pfam03211 716540014615 HMMPfam hit to PF03211, Pectate lyase, score 3.6e-115 716540014616 YopJ Serine/Threonine acetyltransferase; Region: YopJ; cl07849 716540014617 HMMPfam hit to PF03421, Peptidase C55 family, score 2e-78 716540014618 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 716540014619 HMMPfam hit to PF05932, Tir chaperone protein (CesT), score 4.6e-37 716540014620 HrpZ; Region: Hairpins; pfam04877 716540014621 HMMPfam hit to PF07132, Harpin protein (HrpN), score 1.4e-271 716540014622 Signal peptide predicted for EAM_2879 by SignalP 2.0 HMM (Signal peptide probability 0.991) with cleavage site probability 0.450 between residues 21 and 22 716540014623 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540014624 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 716540014625 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 716540014626 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 716540014627 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 716540014628 HMMPfam hit to PF00263, Bacterial type II and III secretion system, score 1.7e-70 716540014629 HMMPfam hit to PF03958, Bacterial type II/III secretion system sho, score 2e-15 716540014630 HMMPfam hit to PF03958, Bacterial type II/III secretion system sho, score 1.2e-09 716540014631 Signal peptide predicted for EAM_2880 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 26 and 27 716540014632 HrpF protein; Region: HrpF; pfam06266 716540014633 HMMPfam hit to PF06266, HrpF protein, score 6.6e-48 716540014634 HrpE/YscL/FliH and V-type ATPase subunit E; Region: HrpE; pfam06188 716540014635 HMMPfam hit to PF06188, HrpE protein, score 1.1e-117 716540014636 type III secretion apparatus lipoprotein, YscJ/HrcJ family; Region: III_secr_YscJ; TIGR02544 716540014637 1 transmembrane helix predicted for EAM_2885 by TMHMM2.0 at aa 219-241 716540014638 HMMPfam hit to PF01514, Secretory protein of YscJ/FliF family, score 1e-95 716540014639 Signal peptide predicted for EAM_2885 by SignalP 2.0 HMM (Signal peptide probability 0.620) with cleavage site probability 0.278 between residues 24 and 25 716540014640 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540014641 Type III secretion needle MxiH like; Region: MxiH; pfam09392 716540014642 Signal peptide predicted for EAM_2887 by SignalP 2.0 HMM (Signal peptide probability 0.990) with cleavage site probability 0.541 between residues 20 and 21 716540014643 HMMPfam hit to PF01863, Protein of unknown function DUF45, score 1.1e-72 716540014644 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 716540014645 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716540014646 Walker A motif; other site 716540014647 ATP binding site [chemical binding]; other site 716540014648 Walker B motif; other site 716540014649 arginine finger; other site 716540014650 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 716540014651 HMMPfam hit to PF02954, Bacterial regulatory protein, Fis fam, score 3.5e-08 716540014652 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 716540014653 PS00688 Sigma-54 interaction domain C-terminal part signature. 716540014654 HMMPfam hit to PF00158, Sigma-54 interaction domain, score 9.5e-98 716540014655 HMMPfam hit to PF07728, ATPase family associated with various, score 0.00028 716540014656 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 716540014657 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 716540014658 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 716540014659 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716540014660 active site 716540014661 phosphorylation site [posttranslational modification] 716540014662 intermolecular recognition site; other site 716540014663 dimerization interface [polypeptide binding]; other site 716540014664 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 716540014665 DNA binding residues [nucleotide binding] 716540014666 dimerization interface [polypeptide binding]; other site 716540014667 PS00294 Prenyl group binding site (CAAX box). 716540014668 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR fami, score 5e-15 716540014669 PS00622 Bacterial regulatory proteins, luxR family signature. 716540014670 HMMPfam hit to PF00072, Response regulator receiver domain, score 1e-35 716540014671 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 716540014672 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 716540014673 putative active site [active] 716540014674 heme pocket [chemical binding]; other site 716540014675 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 716540014676 putative active site [active] 716540014677 heme pocket [chemical binding]; other site 716540014678 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 716540014679 Histidine kinase; Region: HisKA_3; pfam07730 716540014680 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716540014681 ATP binding site [chemical binding]; other site 716540014682 Mg2+ binding site [ion binding]; other site 716540014683 G-X-G motif; other site 716540014684 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 1.6e-15 716540014685 HMMPfam hit to PF07730, Histidine kinase, score 3e-21 716540014686 HMMPfam hit to PF08448, PAS fold, score 2.2e-13 716540014687 HMMPfam hit to PF00989, PAS fold, score 6e-05 716540014688 HMMPfam hit to PF08448, PAS fold, score 5.8e-06 716540014689 HMMPfam hit to PF00989, PAS fold, score 7.5e-07 716540014690 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 716540014691 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 716540014692 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 716540014693 DNA binding residues [nucleotide binding] 716540014694 HMMPfam hit to PF04545, Sigma-70, region, score 7.3e-09 716540014695 HMMPfam hit to PF08281, Sigma-70, region, score 6.8e-12 716540014696 HMMPfam hit to PF04542, Sigma-70 region, score 9.9e-18 716540014697 HrpJ-like domain; Region: HrpJ; pfam07201 716540014698 TyeA; Region: TyeA; cl07611 716540014699 HMMPfam hit to PF07201, Hypersensitivity response secretion protein, score 3.7e-97 716540014700 type III secretion protein, HrcV family; Region: hrcV; TIGR01399 716540014701 FHIPEP family; Region: FHIPEP; pfam00771 716540014702 7 transmembrane helices predicted for EAM_2896 by TMHMM2.0 at aa 21-38, 42-64, 69-91, 111-133, 203-222, 232-254 and 299-321 716540014703 HMMPfam hit to PF00771, FHIPEP family, score 0 716540014704 PS00994 Bacterial export FHIPEP family signature. 716540014705 FHA domain; Region: FHA; pfam00498 716540014706 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 716540014707 HMMPfam hit to PF00498, FHA domain, score 1.2e-10 716540014708 type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546 716540014709 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 716540014710 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 716540014711 Walker A motif; other site 716540014712 ATP binding site [chemical binding]; other site 716540014713 Walker B motif; other site 716540014714 HMMPfam hit to PF02874, ATP synthase alpha/beta family, beta-ba, score 2.8e-08 716540014715 HMMPfam hit to PF00006, ATP synthase alpha/beta family, nucleot, score 4e-119 716540014716 PS00017 ATP/GTP-binding site motif A (P-loop). 716540014717 PS00017 ATP/GTP-binding site motif A (P-loop). 716540014718 PS00152 ATP synthase alpha and beta subunits signature. 716540014719 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540014720 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 716540014721 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 716540014722 HMMPfam hit to PF01052, Surface presentation of antigens (SPOA) prot, score 2.2e-27 716540014723 type III secretion apparatus protein, YscR/HrcR family; Region: yscR; TIGR01102 716540014724 4 transmembrane helices predicted for EAM_2902 by TMHMM2.0 at aa 10-32, 53-72, 158-180 and 187-209 716540014725 HMMPfam hit to PF00813, FliP family, score 1.2e-125 716540014726 PS01060 Flagella transport protein fliP family signature 1. 716540014727 PS01061 Flagella transport protein fliP family signature 2. 716540014728 type III secretion protein, HrpO family; Region: fliQ_rel_III; TIGR01403 716540014729 HMMPfam hit to PF01313, Bacterial export proteins, family, score 1.9e-41 716540014730 Signal peptide predicted for EAM_2903 by SignalP 2.0 HMM (Signal peptide probability 0.983) with cleavage site probability 0.519 between residues 24 and 25 716540014731 2 transmembrane helices predicted for EAM_2903 by TMHMM2.0 at aa 13-35 and 45-67 716540014732 Bacterial export proteins, family 1; Region: Bac_export_1; pfam01311 716540014733 HMMPfam hit to PF01311, Bacterial export proteins, family, score 3.3e-111 716540014734 6 transmembrane helices predicted for EAM_2904 by TMHMM2.0 at aa 15-37, 44-66, 81-103, 134-153, 188-210 and 217-239 716540014735 type III secretion protein, YscU/HrpY family; Region: FlhB_rel_III; TIGR01404 716540014736 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 716540014737 HMMPfam hit to PF01312, FlhB HrpN YscU SpaS Family, score 2.7e-186 716540014738 2 transmembrane helices predicted for EAM_2905 by TMHMM2.0 at aa 74-96 and 136-158 716540014739 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716540014740 Coenzyme A binding pocket [chemical binding]; other site 716540014741 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 7.5e-11 716540014742 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 716540014743 active site 716540014744 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 716540014745 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 716540014746 Amidinotransferase; Region: Amidinotransf; cl12043 716540014747 HMMPfam hit to PF02274, Amidinotransferase, score 0.00016 716540014748 PS00687 Aldehyde dehydrogenases glutamic acid active site. 716540014749 PS00017 ATP/GTP-binding site motif A (P-loop). 716540014750 VirK protein; Region: VirK; pfam06903 716540014751 HMMPfam hit to PF06903, VirK protein, score 1.2e-08 716540014752 Signal peptide predicted for EAM_2912 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.977 between residues 20 and 21 716540014753 C-lysozyme inhibitor; Provisional; Region: PRK09993 716540014754 Signal peptide predicted for EAM_2913 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.938 between residues 30 and 31 716540014755 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 716540014756 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 716540014757 HMMPfam hit to PF00144, Beta-lactamase, score 3.8e-94 716540014758 PS00336 Beta-lactamase class-C active site. 716540014759 1 transmembrane helix predicted for EAM_2914 by TMHMM2.0 at aa 7-29 716540014760 Signal peptide predicted for EAM_2914 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.979 between residues 25 and 26 716540014761 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 716540014762 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716540014763 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 716540014764 dimerization interface [polypeptide binding]; other site 716540014765 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.2e-17 716540014766 PS00044 Bacterial regulatory proteins, lysR family signature. 716540014767 HMMPfam hit to PF03466, LysR substrate binding domain, score 2.3e-39 716540014768 carbon starvation protein A; Provisional; Region: PRK15015 716540014769 Carbon starvation protein CstA; Region: CstA; pfam02554 716540014770 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 716540014771 16 transmembrane helices predicted for EAM_2916 by TMHMM2.0 at aa 26-48, 54-76, 111-133, 138-160, 181-203, 213-235, 240-262, 277-299, 304-326, 346-368, 385-407, 506-525, 554-576, 586-608, 615-637 and 686-708 716540014772 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540014773 HMMPfam hit to PF02554, Carbon starvation protein CstA, score 2e-265 716540014774 Protein of unknown function (DUF466); Region: DUF466; pfam04328 716540014775 HMMPfam hit to PF04328, Protein of unknown function (DUF466), score 1.1e-37 716540014776 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 716540014777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716540014778 active site 716540014779 phosphorylation site [posttranslational modification] 716540014780 intermolecular recognition site; other site 716540014781 dimerization interface [polypeptide binding]; other site 716540014782 LytTr DNA-binding domain; Region: LytTR; pfam04397 716540014783 HMMPfam hit to PF04397, LytTr DNA-binding domain, score 3.5e-27 716540014784 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.8e-33 716540014785 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 716540014786 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 716540014787 GAF domain; Region: GAF; pfam01590 716540014788 Histidine kinase; Region: His_kinase; pfam06580 716540014789 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716540014790 ATP binding site [chemical binding]; other site 716540014791 Mg2+ binding site [ion binding]; other site 716540014792 G-X-G motif; other site 716540014793 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 3.3e-10 716540014794 HMMPfam hit to PF06580, Histidine kinase, score 2.5e-40 716540014795 HMMPfam hit to PF01590, GAF domain, score 1.8e-05 716540014796 6 transmembrane helices predicted for EAM_2919 by TMHMM2.0 at aa 7-24, 44-63, 75-97, 107-129, 142-161 and 176-195 716540014797 HMMPfam hit to PF07694, 5TMR of 5TMR-LYT, score 6.9e-36 716540014798 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 716540014799 Signal peptide predicted for EAM_2920 by SignalP 2.0 HMM (Signal peptide probability 0.798) with cleavage site probability 0.156 between residues 46 and 47 716540014800 4 transmembrane helices predicted for EAM_2920 by TMHMM2.0 at aa 2-21, 31-50, 57-79 and 83-101 716540014801 HMMPfam hit to PF00893, Small Multidrug Resistance protein, score 3.6e-24 716540014802 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 716540014803 HMMPfam hit to PF00893, Small Multidrug Resistance protein, score 4.2e-37 716540014804 4 transmembrane helices predicted for EAM_2921 by TMHMM2.0 at aa 10-29, 36-53, 63-85 and 92-106 716540014805 aromatic amino acid exporter; Provisional; Region: PRK11689 716540014806 Signal peptide predicted for EAM_2922 by SignalP 2.0 HMM (Signal peptide probability 0.935) with cleavage site probability 0.221 between residues 18 and 19 716540014807 10 transmembrane helices predicted for EAM_2922 by TMHMM2.0 at aa 7-25, 35-57, 64-86, 91-113, 120-142, 157-175, 182-199, 209-231, 238-260 and 270-289 716540014808 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 0.0014 716540014809 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 716540014810 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 716540014811 dimerization interface [polypeptide binding]; other site 716540014812 putative Zn2+ binding site [ion binding]; other site 716540014813 putative DNA binding site [nucleotide binding]; other site 716540014814 AsnC family; Region: AsnC_trans_reg; pfam01037 716540014815 HMMPfam hit to PF01037, AsnC family, score 1.4e-21 716540014816 Signal peptide predicted for EAM_2924 by SignalP 2.0 HMM (Signal peptide probability 0.980) with cleavage site probability 0.692 between residues 26 and 27 716540014817 1 transmembrane helix predicted for EAM_2924 by TMHMM2.0 at aa 5-22 716540014818 PAS fold; Region: PAS_4; pfam08448 716540014819 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 716540014820 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 716540014821 DNA binding residues [nucleotide binding] 716540014822 dimerization interface [polypeptide binding]; other site 716540014823 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR family, score 0.00047 716540014824 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 716540014825 Na binding site [ion binding]; other site 716540014826 HMMPfam hit to PF02133, Permease for cytosine/purines, uracil,, score 5.3e-09 716540014827 12 transmembrane helices predicted for EAM_2928 by TMHMM2.0 at aa 20-42, 52-74, 94-113, 128-150, 155-177, 192-214, 227-249, 259-281, 309-331, 335-357, 378-400 and 405-427 716540014828 Transcriptional regulators [Transcription]; Region: PurR; COG1609 716540014829 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 716540014830 DNA binding site [nucleotide binding] 716540014831 domain linker motif; other site 716540014832 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 716540014833 dimerization interface (closed form) [polypeptide binding]; other site 716540014834 ligand binding site [chemical binding]; other site 716540014835 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 3e-12 716540014836 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 6.1e-11 716540014837 PS00356 Bacterial regulatory proteins, lacI family signature. 716540014838 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 716540014839 active site 716540014840 P-loop; other site 716540014841 phosphorylation site [posttranslational modification] 716540014842 Signal peptide predicted for EAM_2930 by SignalP 2.0 HMM (Signal peptide probability 0.979) with cleavage site probability 0.742 between residues 20 and 21 716540014843 HMMPfam hit to PF02302, PTS system, Lactose/Cellobiose specific IIB, score 9.5e-37 716540014844 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 716540014845 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 716540014846 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 1.5e-76 716540014847 10 transmembrane helices predicted for EAM_2931 by TMHMM2.0 at aa 35-57, 77-99, 112-129, 139-161, 181-203, 213-235, 240-262, 284-306, 341-363 and 395-414 716540014848 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 716540014849 methionine cluster; other site 716540014850 active site 716540014851 phosphorylation site [posttranslational modification] 716540014852 metal binding site [ion binding]; metal-binding site 716540014853 HMMPfam hit to PF02255, PTS system, Lactose/Cellobiose specific IIA, score 4.1e-33 716540014854 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 716540014855 beta-galactosidase; Region: BGL; TIGR03356 716540014856 HMMPfam hit to PF00232, Glycosyl hydrolase family, score 7.9e-171 716540014857 PS00653 Glycosyl hydrolases family 1 N-terminal signature. 716540014858 PS00572 Glycosyl hydrolases family 1 active site. 716540014859 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 716540014860 beta-galactosidase; Region: BGL; TIGR03356 716540014861 HMMPfam hit to PF00232, Glycosyl hydrolase family, score 5e-140 716540014862 PS00653 Glycosyl hydrolases family 1 N-terminal signature. 716540014863 PS00572 Glycosyl hydrolases family 1 active site. 716540014864 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 716540014865 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 716540014866 HMMPfam hit to PF01019, Gamma-glutamyltranspeptidase, score 1.9e-229 716540014867 PS00462 Gamma-glutamyltranspeptidase signature. 716540014868 Signal peptide predicted for EAM_2935 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.988 between residues 23 and 24 716540014869 Phytochelatin synthase; Region: Phytochelatin; pfam05023 716540014870 Signal peptide predicted for EAM_2936 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.983 between residues 21 and 22 716540014871 5 transmembrane helices predicted for EAM_2937 by TMHMM2.0 at aa 12-34, 44-63, 68-90, 105-127 and 148-170 716540014872 HMMPfam hit to PF02600, Disulfide bond formation protein DsbB, score 9.9e-05 716540014873 2 transmembrane helices predicted for EAM_2938 by TMHMM2.0 at aa 2-19 and 29-51 716540014874 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716540014875 H-loop/switch region; other site 716540014876 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 716540014877 Ferritin-like domain; Region: Ferritin; pfam00210 716540014878 ferroxidase diiron center [ion binding]; other site 716540014879 HMMPfam hit to PF00210, Ferritin-like domain, score 1.9e-46 716540014880 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 716540014881 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 716540014882 putative ligand binding residues [chemical binding]; other site 716540014883 HMMPfam hit to PF01497, Periplasmic binding protein, score 5e-06 716540014884 Signal peptide predicted for EAM_2941 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 22 and 23 716540014885 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 716540014886 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 716540014887 active site 716540014888 HMMPfam hit to PF01569, PAP2 superfamily, score 2.6e-05 716540014889 Signal peptide predicted for EAM_2942 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.979 between residues 20 and 21 716540014890 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 716540014891 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 716540014892 DNA binding site [nucleotide binding] 716540014893 HMMPfam hit to PF00486, Transcriptional regulatory protein, C ter, score 7.5e-12 716540014894 1 transmembrane helix predicted for EAM_2943 by TMHMM2.0 at aa 159-181 716540014895 Signal peptide predicted for EAM_2944 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.488 between residues 22 and 23 716540014896 1 transmembrane helix predicted for EAM_2944 by TMHMM2.0 at aa 7-24 716540014897 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 716540014898 Signal peptide predicted for EAM_2945 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.993 between residues 24 and 25 716540014899 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 716540014900 2 transmembrane helices predicted for EAM_2946 by TMHMM2.0 at aa 31-53 and 58-80 716540014901 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 716540014902 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 716540014903 DNA-binding site [nucleotide binding]; DNA binding site 716540014904 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 716540014905 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716540014906 homodimer interface [polypeptide binding]; other site 716540014907 catalytic residue [active] 716540014908 HMMPfam hit to PF00155, Aminotransferase class I and II, score 1.4e-10 716540014909 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR fam, score 2.2e-13 716540014910 Fimbrial operon 3 716540014911 Signal peptide predicted for EAM_2948 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.906 between residues 24 and 25 716540014912 Spore Coat Protein U domain; Region: SCPU; pfam05229 716540014913 Signal peptide predicted for EAM_2949 by SignalP 2.0 HMM (Signal peptide probability 0.968) with cleavage site probability 0.409 between residues 35 and 36 716540014914 1 transmembrane helix predicted for EAM_2949 by TMHMM2.0 at aa 7-29 716540014915 HMMPfam hit to PF05229, no description, score 5.2e-08 716540014916 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 716540014917 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 716540014918 Signal peptide predicted for EAM_2950 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.967 between residues 25 and 26 716540014919 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 716540014920 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 716540014921 PapC C-terminal domain; Region: PapC_C; pfam13953 716540014922 Signal peptide predicted for EAM_2951 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.789 between residues 30 and 31 716540014923 HMMPfam hit to PF00577, Fimbrial Usher protein, score 8.1e-12 716540014924 PS01151 Fimbrial biogenesis outer membrane usher protein signature. 716540014925 Spore Coat Protein U domain; Region: SCPU; pfam05229 716540014926 Spore Coat Protein U domain; Region: SCPU; pfam05229 716540014927 Signal peptide predicted for EAM_2952 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.908 between residues 19 and 20 716540014928 HMMPfam hit to PF05229, Spore Coat Protein U domain, score 3.3e-05 716540014929 HMMPfam hit to PF05229, Spore Coat Protein U domain, score 5.4e-12 716540014930 oxidoreductase; Provisional; Region: PRK07985 716540014931 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 716540014932 NAD(P) binding site [chemical binding]; other site 716540014933 active site 716540014934 HMMPfam hit to PF00106, short chain dehydrogenase, score 4.7e-16 716540014935 PS00216 Sugar transport proteins signature 1. 716540014936 PS00061 Short-chain dehydrogenases/reductases family signature. 716540014937 citrate-proton symporter; Provisional; Region: PRK15075 716540014938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540014939 putative substrate translocation pore; other site 716540014940 HMMPfam hit to PF00083, Sugar (and other) transporter, score 3.6e-48 716540014941 12 transmembrane helices predicted for EAM_2954 by TMHMM2.0 at aa 21-43, 58-80, 89-111, 121-143, 164-181, 191-208, 240-262, 277-299, 306-328, 338-360, 372-394 and 404-423 716540014942 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.1e-27 716540014943 PS00217 Sugar transport proteins signature 2. 716540014944 PS00216 Sugar transport proteins signature 1. 716540014945 biopolymer transport protein ExbD; Provisional; Region: PRK11267 716540014946 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 716540014947 HMMPfam hit to PF02472, Biopolymer transport protein ExbD/TolR, score 2.1e-18 716540014948 1 transmembrane helix predicted for EAM_2955 by TMHMM2.0 at aa 20-42 716540014949 biopolymer transport protein ExbB; Provisional; Region: PRK10414 716540014950 HMMPfam hit to PF01618, MotA/TolQ/ExbB proton channel family, score 1.3e-49 716540014951 3 transmembrane helices predicted for EAM_2956 by TMHMM2.0 at aa 20-42, 131-153 and 177-199 716540014952 cystathionine beta-lyase; Provisional; Region: PRK08114 716540014953 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 716540014954 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 716540014955 catalytic residue [active] 716540014956 HMMPfam hit to PF01053, Cys/Met metabolism PLP-dependent enzy, score 2.7e-148 716540014957 PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. 716540014958 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 716540014959 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 716540014960 4 transmembrane helices predicted for EAM_2958 by TMHMM2.0 at aa 24-46, 66-88, 153-175 and 190-212 716540014961 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 716540014962 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716540014963 catalytic residue [active] 716540014964 HMMPfam hit to PF00282, Pyridoxal-dependent decarboxylase conse, score 1.3e-38 716540014965 Signal peptide predicted for EAM_2959 by SignalP 2.0 HMM (Signal peptide probability 0.849) with cleavage site probability 0.406 between residues 17 and 18 716540014966 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 716540014967 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 716540014968 inhibitor-cofactor binding pocket; inhibition site 716540014969 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716540014970 catalytic residue [active] 716540014971 HMMPfam hit to PF00202, Aminotransferase class-III, score 5.6e-148 716540014972 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 716540014973 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 716540014974 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 716540014975 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716540014976 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716540014977 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 1.2e-06 716540014978 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 6.4e-10 716540014979 PS00041 Bacterial regulatory proteins, araC family signature. 716540014980 HMMPfam hit to PF06719, AraC-type transcriptional regulator N-termin, score 2.9e-64 716540014981 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 716540014982 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 716540014983 active site 716540014984 catalytic tetrad [active] 716540014985 HMMPfam hit to PF00248, Aldo/keto reductase family, score 3.9e-117 716540014986 PS00798 Aldo/keto reductase family signature 1. 716540014987 PS00062 Aldo/keto reductase family signature 2. 716540014988 PS00063 Aldo/keto reductase family active site signature. 716540014989 FtsI repressor; Provisional; Region: PRK10883 716540014990 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 716540014991 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 716540014992 HMMPfam hit to PF07731, Multicopper oxidase, score 2.9e-15 716540014993 HMMPfam hit to PF07732, Multicopper oxidase, score 5.9e-31 716540014994 Signal peptide predicted for EAM_2963 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.922 between residues 27 and 28 716540014995 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 716540014996 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 716540014997 putative acyl-acceptor binding pocket; other site 716540014998 3 transmembrane helices predicted for EAM_2964 by TMHMM2.0 at aa 5-27, 97-116 and 161-180 716540014999 HMMPfam hit to PF01553, Acyltransferase, score 7e-45 716540015000 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 716540015001 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 716540015002 CAP-like domain; other site 716540015003 active site 716540015004 primary dimer interface [polypeptide binding]; other site 716540015005 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 6.8e-06 716540015006 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 716540015007 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 0.0038 716540015008 HMMPfam hit to PF00521, DNA gyrase/topoisomerase IV, subunit A, score 1.5e-252 716540015009 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 716540015010 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 716540015011 substrate binding pocket [chemical binding]; other site 716540015012 membrane-bound complex binding site; other site 716540015013 hinge residues; other site 716540015014 HMMPfam hit to PF00497, Bacterial extracellular solute-binding prot, score 3.4e-22 716540015015 PS00213 Lipocalin signature. 716540015016 Signal peptide predicted for EAM_2966 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.803 between residues 19 and 20 716540015017 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 716540015018 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 716540015019 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540015020 putative substrate translocation pore; other site 716540015021 Signal peptide predicted for EAM_2970 by SignalP 2.0 HMM (Signal peptide probability 0.876) with cleavage site probability 0.592 between residues 22 and 23 716540015022 14 transmembrane helices predicted for EAM_2970 by TMHMM2.0 at aa 9-31, 46-68, 75-97, 101-123, 136-158, 163-185, 198-215, 225-242, 263-285, 300-322, 329-351, 361-383, 396-418 and 467-489 716540015023 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1e-49 716540015024 peptide synthase; Validated; Region: PRK05691 716540015025 HMMPfam hit to PF00668, Condensation domain, score 3.1e-06 716540015026 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 716540015027 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 716540015028 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 716540015029 active site 716540015030 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 716540015031 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 716540015032 KR domain; Region: KR; pfam08659 716540015033 NAD(P) binding site [chemical binding]; other site 716540015034 active site 716540015035 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 716540015036 HMMPfam hit to PF00550, Phosphopantetheine attachment site, score 2.7e-12 716540015037 HMMPfam hit to PF00109, Beta-ketoacyl synthase, N-terminal do, score 5.6e-84 716540015038 PS00606 Beta-ketoacyl synthases active site. 716540015039 PS00098 Thiolases acyl-enzyme intermediate signature. 716540015040 HMMPfam hit to PF02801, Beta-ketoacyl synthase, C-terminal do, score 1.9e-78 716540015041 HMMPfam hit to PF00698, Acyl transferase domain, score 1.2e-22 716540015042 HMMPfam hit to PF00106, short chain dehydrogenase, score 2.1e-42 716540015043 HMMPfam hit to PF00550, Phosphopantetheine attachment site, score 1.9e-14 716540015044 PS00012 Phosphopantetheine attachment site. 716540015045 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 716540015046 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 716540015047 active site 716540015048 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 716540015049 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 716540015050 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 716540015051 KR domain; Region: KR; pfam08659 716540015052 putative NADP binding site [chemical binding]; other site 716540015053 active site 716540015054 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 716540015055 HMMPfam hit to PF00109, Beta-ketoacyl synthase, N-terminal do, score 2.5e-111 716540015056 PS00606 Beta-ketoacyl synthases active site. 716540015057 HMMPfam hit to PF02801, Beta-ketoacyl synthase, C-terminal do, score 8.8e-73 716540015058 PS00017 ATP/GTP-binding site motif A (P-loop). 716540015059 HMMPfam hit to PF00698, Acyl transferase domain, score 1.3e-62 716540015060 HMMPfam hit to PF00106, short chain dehydrogenase, score 1.4e-54 716540015061 HMMPfam hit to PF00550, Phosphopantetheine attachment site, score 1.1e-08 716540015062 Condensation domain; Region: Condensation; pfam00668 716540015063 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 716540015064 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 716540015065 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 716540015066 acyl-activating enzyme (AAE) consensus motif; other site 716540015067 AMP binding site [chemical binding]; other site 716540015068 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 716540015069 HMMPfam hit to PF00668, Condensation domain, score 8.1e-22 716540015070 HMMPfam hit to PF00501, AMP-binding enzyme, score 4.7e-111 716540015071 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 716540015072 HMMPfam hit to PF00550, Phosphopantetheine attachment site, score 1.8e-10 716540015073 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 716540015074 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 716540015075 active site 716540015076 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 716540015077 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 716540015078 NAD(P) binding site [chemical binding]; other site 716540015079 active site 716540015080 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 716540015081 HMMPfam hit to PF00109, Beta-ketoacyl synthase, N-terminal do, score 5.7e-69 716540015082 PS00606 Beta-ketoacyl synthases active site. 716540015083 HMMPfam hit to PF02801, Beta-ketoacyl synthase, C-terminal do, score 2.8e-64 716540015084 HMMPfam hit to PF00106, short chain dehydrogenase, score 2.3e-20 716540015085 HMMPfam hit to PF00550, Phosphopantetheine attachment site, score 1.4e-12 716540015086 PS00012 Phosphopantetheine attachment site. 716540015087 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 716540015088 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 716540015089 active site 716540015090 HMMPfam hit to PF00109, Beta-ketoacyl synthase, N-terminal do, score 4.4e-57 716540015091 HMMPfam hit to PF02801, Beta-ketoacyl synthase, C-terminal do, score 5.5e-63 716540015092 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 716540015093 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 716540015094 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 716540015095 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 716540015096 catalytic residue [active] 716540015097 HMMPfam hit to PF00550, Phosphopantetheine attachment site, score 1.6e-12 716540015098 HMMPfam hit to PF00202, Aminotransferase class-III, score 4.3e-21 716540015099 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 716540015100 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 716540015101 Dihydroorotate dehydrogenase (DHOD) and Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the...; Region: DHOD_DHPD_FMN; cd02810 716540015102 active site 716540015103 FMN binding site [chemical binding]; other site 716540015104 substrate binding site [chemical binding]; other site 716540015105 HMMPfam hit to PF01180, Dihydroorotate dehydrogenase, score 4.8e-10 716540015106 PS00912 Dihydroorotate dehydrogenase signature 2. 716540015107 Creatinine amidohydrolase; Region: Creatininase; pfam02633 716540015108 HMMPfam hit to PF02633, Creatinine amidohydrolase, score 1.8e-07 716540015109 Protein of unknown function (DUF1062); Region: DUF1062; pfam06353 716540015110 HMMPfam hit to PF06353, Protein of unknown function (DUF1062), score 4.6e-46 716540015111 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 716540015112 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 716540015113 HMMPfam hit to PF00975, Thioesterase domain, score 5.8e-22 716540015114 HMMPfam hit to PF00561, alpha/beta hydrolase fold, score 0.00053 716540015115 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 716540015116 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716540015117 ATP binding site [chemical binding]; other site 716540015118 Mg2+ binding site [ion binding]; other site 716540015119 G-X-G motif; other site 716540015120 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 716540015121 anchoring element; other site 716540015122 dimer interface [polypeptide binding]; other site 716540015123 ATP binding site [chemical binding]; other site 716540015124 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 716540015125 active site 716540015126 metal binding site [ion binding]; metal-binding site 716540015127 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 716540015128 HMMPfam hit to PF00986, DNA gyrase B subunit, carboxyl terminus, score 3.3e-30 716540015129 PS00177 DNA topoisomerase II signature. 716540015130 HMMPfam hit to PF00204, DNA gyrase B, score 3.9e-57 716540015131 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and H, score 2.5e-25 716540015132 esterase YqiA; Provisional; Region: PRK11071 716540015133 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 716540015134 HMMPfam hit to PF05728, Uncharacterised protein family (UPF0227), score 1e-102 716540015135 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 716540015136 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 716540015137 active site 716540015138 metal binding site [ion binding]; metal-binding site 716540015139 hexamer interface [polypeptide binding]; other site 716540015140 HMMPfam hit to PF08413, Calcineurin-like phosphoesterase C-term, score 3.5e-42 716540015141 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 7.6e-17 716540015142 putative dehydrogenase; Provisional; Region: PRK11039 716540015143 HMMPfam hit to PF06853, Protein of unknown function (DUF1249), score 3.8e-87 716540015144 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 716540015145 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 716540015146 dimer interface [polypeptide binding]; other site 716540015147 ADP-ribose binding site [chemical binding]; other site 716540015148 active site 716540015149 nudix motif; other site 716540015150 metal binding site [ion binding]; metal-binding site 716540015151 HMMPfam hit to PF00293, NUDIX domain, score 1.6e-19 716540015152 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 716540015153 Signal peptide predicted for EAM_2988 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.934 between residues 24 and 25 716540015154 HMMPfam hit to PF02321, Outer membrane efflux protein, score 9.7e-46 716540015155 HMMPfam hit to PF02321, Outer membrane efflux protein, score 3.5e-50 716540015156 hypothetical protein; Provisional; Region: PRK11653 716540015157 Signal peptide predicted for EAM_2989 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.755 between residues 40 and 41 716540015158 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540015159 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 716540015160 HMMPfam hit to PF03738, Glutathionylspermidine synthase, score 2.5e-229 716540015161 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 716540015162 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 716540015163 putative active site [active] 716540015164 metal binding site [ion binding]; metal-binding site 716540015165 HMMPfam hit to PF02900, Catalytic LigB subunit of aromatic ring-open, score 6.4e-82 716540015166 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 716540015167 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 716540015168 HMMPfam hit to PF00926, 3,4-dihydroxy-2-butanone 4-phosphate sy, score 7.6e-126 716540015169 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 716540015170 HMMPfam hit to PF04380, Protein of unknown function (DUF526), score 1e-44 716540015171 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 716540015172 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 716540015173 putative ribose interaction site [chemical binding]; other site 716540015174 putative ADP binding site [chemical binding]; other site 716540015175 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 716540015176 active site 716540015177 nucleotide binding site [chemical binding]; other site 716540015178 HIGH motif; other site 716540015179 KMSKS motif; other site 716540015180 HMMPfam hit to PF01467, Cytidylyltransferase, score 4.4e-21 716540015181 HMMPfam hit to PF00294, pfkB family carbohydrate kinase, score 3.5e-49 716540015182 PS00583 pfkB family of carbohydrate kinases signature 1. 716540015183 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 716540015184 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 716540015185 metal binding triad; other site 716540015186 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 716540015187 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 716540015188 metal binding triad; other site 716540015189 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 716540015190 HMMPfam hit to PF03710, Glutamate-ammonia ligase adenylyltransferase, score 7e-128 716540015191 HMMPfam hit to PF03710, Glutamate-ammonia ligase adenylyltransferase, score 1.3e-124 716540015192 Uncharacterized conserved protein [Function unknown]; Region: COG3025 716540015193 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 716540015194 putative active site [active] 716540015195 putative metal binding residues [ion binding]; other site 716540015196 signature motif; other site 716540015197 putative triphosphate binding site [ion binding]; other site 716540015198 HMMPfam hit to PF01928, CYTH domain, score 1.5e-43 716540015199 SH3 domain-containing protein; Provisional; Region: PRK10884 716540015200 Bacterial SH3 domain homologues; Region: SH3b; smart00287 716540015201 Signal peptide predicted for EAM_2997 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 22 and 23 716540015202 1 transmembrane helix predicted for EAM_2997 by TMHMM2.0 at aa 169-191 716540015203 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 716540015204 Poly A polymerase head domain; Region: PolyA_pol; pfam01743 716540015205 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 716540015206 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 716540015207 Zn2+ binding site [ion binding]; other site 716540015208 Mg2+ binding site [ion binding]; other site 716540015209 HMMPfam hit to PF01743, Poly A polymerase family, score 2e-59 716540015210 HMMPfam hit to PF01966, HD domain, score 4.1e-16 716540015211 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 716540015212 7 transmembrane helices predicted for EAM_2999 by TMHMM2.0 at aa 50-69, 89-108, 115-137, 152-171, 184-206, 226-248 and 253-272 716540015213 HMMPfam hit to PF02673, Bacitracin resistance protein BacA, score 2.5e-138 716540015214 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 716540015215 homooctamer interface [polypeptide binding]; other site 716540015216 active site 716540015217 HMMPfam hit to PF02152, Dihydroneopterin aldolase, score 1.2e-44 716540015218 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 716540015219 Signal peptide predicted for EAM_3001 by SignalP 2.0 HMM (Signal peptide probability 0.862) with cleavage site probability 0.758 between residues 20 and 21 716540015220 4 transmembrane helices predicted for EAM_3001 by TMHMM2.0 at aa 7-29, 78-100, 107-126 and 136-158 716540015221 HMMPfam hit to PF02660, Domain of unknown function DUF, score 1.9e-101 716540015222 UGMP family protein; Validated; Region: PRK09604 716540015223 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 716540015224 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2; cl00208 716540015225 HMMPfam hit to PF00814, Glycoprotease family, score 2.2e-72 716540015226 PS01016 Glycoprotease family signature. 716540015227 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 716540015228 HMMPfam hit to PF01165, Ribosomal protein S21, score 2.6e-35 716540015229 PS01181 Ribosomal protein S21 signature. 716540015230 DNA primase; Validated; Region: dnaG; PRK05667 716540015231 CHC2 zinc finger; Region: zf-CHC2; pfam01807 716540015232 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 716540015233 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 716540015234 active site 716540015235 metal binding site [ion binding]; metal-binding site 716540015236 interdomain interaction site; other site 716540015237 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 716540015238 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 716540015239 HMMPfam hit to PF01807, CHC2 zinc finger, score 3.3e-64 716540015240 HMMPfam hit to PF08275, DNA primase catalytic core, N-terminal, score 1e-66 716540015241 HMMPfam hit to PF01751, Toprim domain, score 1.3e-26 716540015242 HMMPfam hit to PF08278, DNA primase DnaG DnaB-binding, score 9.1e-61 716540015243 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 716540015244 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 716540015245 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 716540015246 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 716540015247 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 716540015248 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 716540015249 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 716540015250 DNA binding residues [nucleotide binding] 716540015251 HMMPfam hit to PF03979, Sigma-70 factor, region, score 1.2e-44 716540015252 HMMPfam hit to PF00140, Sigma-70 factor, region, score 2.6e-15 716540015253 HMMPfam hit to PF04546, Sigma-70, non-essential region, score 4.5e-118 716540015254 HMMPfam hit to PF04542, Sigma-70 region, score 2e-28 716540015255 PS00715 Sigma-70 factors family signature 1. 716540015256 HMMPfam hit to PF04539, Sigma-70 region, score 2.2e-41 716540015257 HMMPfam hit to PF04545, Sigma-70, region, score 1.9e-22 716540015258 PS00716 Sigma-70 factors family signature 2. 716540015259 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 716540015260 active site 716540015261 SUMO-1 interface [polypeptide binding]; other site 716540015262 HMMPfam hit to PF03167, Uracil DNA glycosylase superfamily, score 1.1e-20 716540015263 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 716540015264 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 716540015265 Signal peptide predicted for EAM_3007 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.855 between residues 27 and 28 716540015266 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540015267 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 716540015268 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 716540015269 HMMPfam hit to PF00144, Beta-lactamase, score 6.6e-63 716540015270 1 transmembrane helix predicted for EAM_3009 by TMHMM2.0 at aa 319-341 716540015271 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 716540015272 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 716540015273 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 716540015274 non-specific DNA binding site [nucleotide binding]; other site 716540015275 salt bridge; other site 716540015276 sequence-specific DNA binding site [nucleotide binding]; other site 716540015277 HMMPfam hit to PF01381, Helix-turn-helix, score 1.4e-08 716540015278 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 716540015279 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 716540015280 Signal peptide predicted for EAM_3012 by SignalP 2.0 HMM (Signal peptide probability 0.903) with cleavage site probability 0.671 between residues 18 and 19 716540015281 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540015282 HMMPfam hit to PF03180, NLPA lipoprotein, score 8.1e-121 716540015283 hypothetical protein; Provisional; Region: PRK10396 716540015284 yecA family protein; Region: ygfB_yecA; TIGR02292 716540015285 Part of AAA domain; Region: AAA_19; pfam13245 716540015286 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 716540015287 AAA domain; Region: AAA_12; pfam13087 716540015288 PS00017 ATP/GTP-binding site motif A (P-loop). 716540015289 HMMPfam hit to PF01527, Transposase, score 3.8e-13 716540015290 Transposase; Region: HTH_Tnp_1; pfam01527 716540015291 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 716540015292 HMMPfam hit to PF05016, Plasmid stabilisation system protein, score 2.6e-13 716540015293 Predicted transcriptional regulator [Transcription]; Region: COG3905 716540015294 PS00018 EF-hand calcium-binding domain. 716540015295 HMMPfam hit to PF01402, Ribbon-helix-helix protein, copG family, score 5.9e-06 716540015296 Methyltransferase domain; Region: Methyltransf_27; pfam13708 716540015297 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 716540015298 HMMPfam hit to PF06755, Protein of unknown function (DUF1219), score 6.8e-33 716540015299 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 716540015300 HMMPfam hit to PF06154, YagB/YeeU/YfjZ family, score 3.1e-55 716540015301 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 716540015302 MPN+ (JAMM) motif; other site 716540015303 Zinc-binding site [ion binding]; other site 716540015304 HMMPfam hit to PF04002, RadC, DNA repair protein, score 1.2e-65 716540015305 PS01302 DNA repair protein radC family signature. 716540015306 HMMPfam hit to PF06067, Domain of unknown function (DUF932), score 1.6e-102 716540015307 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 716540015308 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 716540015309 HMMPfam hit to PF05930, Prophage CP4-57 regulatory protein (AlpA), score 9.9e-19 716540015310 DNA-sulfur modification-associated; Region: DndB; pfam14072 716540015311 DGQHR domain; Region: DGQHR; TIGR03187 716540015312 hypothetical protein; Provisional; Region: PRK06850 716540015313 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 716540015314 Active Sites [active] 716540015315 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 716540015316 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716540015317 Walker A/P-loop; other site 716540015318 ATP binding site [chemical binding]; other site 716540015319 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716540015320 ABC transporter signature motif; other site 716540015321 Walker B; other site 716540015322 D-loop; other site 716540015323 H-loop/switch region; other site 716540015324 HMMPfam hit to PF02463, RecF/RecN/SMC N terminal domain, score 4.8e-08 716540015325 PS00017 ATP/GTP-binding site motif A (P-loop). 716540015326 Domain of unknown function (DUF1832); Region: DUF1832; pfam08870 716540015327 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 716540015328 Methyltransferase domain; Region: Methyltransf_23; pfam13489 716540015329 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716540015330 S-adenosylmethionine binding site [chemical binding]; other site 716540015331 HMMPfam hit to PF08241, Methyltransferase domain, score 5.1e-10 716540015332 HMMPfam hit to PF08242, Methyltransferase domain, score 2.7e-11 716540015333 Restriction endonuclease; Region: Mrr_cat; pfam04471 716540015334 HMMPfam hit to PF04471, Restriction endonuclease, score 3.6e-27 716540015335 DNA phosphorothioation-dependent restriction protein DptH; Region: dnd_assoc_2; TIGR03237 716540015336 AAA-like domain; Region: AAA_10; pfam12846 716540015337 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 716540015338 PS00017 ATP/GTP-binding site motif A (P-loop). 716540015339 DNA phosphorothioation-dependent restriction protein DptG; Region: dnd_assoc_1; TIGR03236 716540015340 DNA phosphorothioation-dependent restriction protein DptF; Region: dnd_assoc_3; TIGR03238 716540015341 PS00017 ATP/GTP-binding site motif A (P-loop). 716540015342 integrase; Provisional; Region: PRK09692 716540015343 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 716540015344 active site 716540015345 Int/Topo IB signature motif; other site 716540015346 PS00018 EF-hand calcium-binding domain. 716540015347 HMMPfam hit to PF00589, Phage integrase family, score 7.2e-23 716540015348 hypothetical protein; Provisional; Region: PRK11667 716540015349 Signal peptide predicted for EAM_3038 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 24 and 25 716540015350 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 716540015351 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 716540015352 Walker A motif; other site 716540015353 ATP binding site [chemical binding]; other site 716540015354 HMMPfam hit to PF05872, Bacterial protein of unknown function (DUF85, score 0 716540015355 PS00017 ATP/GTP-binding site motif A (P-loop). 716540015356 Predicted membrane protein [Function unknown]; Region: COG2733 716540015357 2 transmembrane helices predicted for EAM_3040 by TMHMM2.0 at aa 13-35 and 402-424 716540015358 HMMPfam hit to PF04286, Protein of unknown function (DUF445), score 4.6e-116 716540015359 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 716540015360 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 716540015361 HMMPfam hit to PF03739, Predicted permease YjgP/YjgQ family, score 2.5e-89 716540015362 6 transmembrane helices predicted for EAM_3042 by TMHMM2.0 at aa 12-31, 62-81, 102-124, 277-295, 307-329 and 333-355 716540015363 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 716540015364 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 716540015365 HMMPfam hit to PF03739, Predicted permease YjgP/YjgQ family, score 2.2e-80 716540015366 6 transmembrane helices predicted for EAM_3043 by TMHMM2.0 at aa 17-39, 59-81, 101-123, 267-289, 296-313 and 328-347 716540015367 multifunctional aminopeptidase A; Provisional; Region: PRK00913 716540015368 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 716540015369 interface (dimer of trimers) [polypeptide binding]; other site 716540015370 Substrate-binding/catalytic site; other site 716540015371 Zn-binding sites [ion binding]; other site 716540015372 HMMPfam hit to PF02789, Cytosol aminopeptidase family, N-term, score 1.8e-43 716540015373 HMMPfam hit to PF00883, Cytosol aminopeptidase family, cataly, score 2.5e-202 716540015374 PS00631 Cytosol aminopeptidase signature. 716540015375 DNA polymerase III subunit chi; Validated; Region: PRK05728 716540015376 HMMPfam hit to PF04364, DNA polymerase III chi subunit, HolC, score 1.4e-67 716540015377 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 716540015378 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 716540015379 HIGH motif; other site 716540015380 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 716540015381 active site 716540015382 KMSKS motif; other site 716540015383 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 716540015384 tRNA binding surface [nucleotide binding]; other site 716540015385 anticodon binding site; other site 716540015386 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 716540015387 HMMPfam hit to PF00133, tRNA synthetases class I (I, L, M and V), score 0 716540015388 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 716540015389 HMMPfam hit to PF08264, Anticodon-binding domain, score 4.2e-66 716540015390 PAS fold; Region: PAS_4; pfam08448 716540015391 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 716540015392 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716540015393 HMMPfam hit to PF08448, PAS fold, score 3.5e-21 716540015394 PS00041 Bacterial regulatory proteins, araC family signature. 716540015395 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 8.2e-08 716540015396 regulatory protein UhpC; Provisional; Region: PRK11663 716540015397 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540015398 putative substrate translocation pore; other site 716540015399 12 transmembrane helices predicted for EAM_3048 by TMHMM2.0 at aa 26-45, 60-79, 92-114, 118-140, 153-175, 185-203, 251-270, 290-309, 322-339, 344-366, 379-401 and 411-433 716540015400 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 4.7e-57 716540015401 PS00012 Phosphopantetheine attachment site. 716540015402 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 716540015403 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 716540015404 active site 716540015405 HMMPfam hit to PF00459, Inositol monophosphatase family, score 1.1e-54 716540015406 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716540015407 Coenzyme A binding pocket [chemical binding]; other site 716540015408 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1e-18 716540015409 RNase E inhibitor protein; Provisional; Region: PRK11191 716540015410 HMMPfam hit to PF06877, Protein of unknown function (DUF1260), score 2.9e-45 716540015411 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 716540015412 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 716540015413 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 716540015414 HMMPfam hit to PF02729, Aspartate/ornithine carbamoyltransferase, ca, score 2.3e-80 716540015415 PS00097 Aspartate and ornithine carbamoyltransferases signature. 716540015416 HMMPfam hit to PF00185, Aspartate/ornithine carbamoyltransferase, As, score 3.1e-92 716540015417 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 716540015418 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 716540015419 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 716540015420 HMMPfam hit to PF02729, Aspartate/ornithine carbamoyltransferase, ca, score 8.2e-77 716540015421 PS00097 Aspartate and ornithine carbamoyltransferases signature. 716540015422 HMMPfam hit to PF00185, Aspartate/ornithine carbamoyltransferase, As, score 6.2e-62 716540015423 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 716540015424 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 716540015425 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 716540015426 HMMPfam hit to PF01948, Aspartate carbamoyltransferase regulatory ch, score 1.5e-55 716540015427 HMMPfam hit to PF02748, Aspartate carbamoyltransferase regulatory ch, score 2e-24 716540015428 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 716540015429 homotrimer interaction site [polypeptide binding]; other site 716540015430 putative active site [active] 716540015431 HMMPfam hit to PF01042, Endoribonuclease L-PSP, score 8.5e-61 716540015432 PS01094 Uncharacterized protein family UPF0076 signature. 716540015433 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 716540015434 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 716540015435 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 716540015436 active site 716540015437 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 716540015438 HMMPfam hit to PF00728, Glycosyl hydrolase family 20, catalyt, score 1.1e-103 716540015439 HMMPfam hit to PF02838, Glycosyl hydrolase family 20, domain, score 1.3e-08 716540015440 Signal peptide predicted for EAM_3057 by SignalP 2.0 HMM (Signal peptide probability 0.987) with cleavage site probability 0.567 between residues 25 and 26 716540015441 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 716540015442 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 716540015443 ATP binding site [chemical binding]; other site 716540015444 putative Mg++ binding site [ion binding]; other site 716540015445 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 716540015446 nucleotide binding region [chemical binding]; other site 716540015447 ATP-binding site [chemical binding]; other site 716540015448 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 2.9e-21 716540015449 HMMPfam hit to PF00176, SNF2 family N-terminal domain, score 3.7e-80 716540015450 HMMPfam hit to PF04434, SWIM zinc finger, score 0.0027 716540015451 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 716540015452 ATP cone domain; Region: ATP-cone; pfam03477 716540015453 Class III ribonucleotide reductase; Region: RNR_III; cd01675 716540015454 effector binding site; other site 716540015455 active site 716540015456 Zn binding site [ion binding]; other site 716540015457 glycine loop; other site 716540015458 HMMPfam hit to PF03477, ATP cone domain, score 1.4e-21 716540015459 HMMPfam hit to PF01228, Glycine radical, score 2.9e-51 716540015460 PS00850 Glycine radical signature. 716540015461 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 716540015462 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 716540015463 FeS/SAM binding site; other site 716540015464 PS01087 Radical activating enzymes signature. 716540015465 Predicted membrane protein [Function unknown]; Region: COG3766 716540015466 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 716540015467 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 716540015468 HMMPfam hit to PF03994, Domain of Unknown Function (DUF350), score 2e-12 716540015469 4 transmembrane helices predicted for EAM_3061 by TMHMM2.0 at aa 10-32, 44-66, 76-98 and 111-130 716540015470 HMMPfam hit to PF03994, Domain of Unknown Function (DUF350), score 2e-10 716540015471 Signal peptide predicted for EAM_3061 by SignalP 2.0 HMM (Signal peptide probability 0.767) with cleavage site probability 0.356 between residues 22 and 23 716540015472 HMMPfam hit to PF01541, GIY-YIG catalytic domain, score 9.3e-17 716540015473 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716540015474 Coenzyme A binding pocket [chemical binding]; other site 716540015475 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1.1e-11 716540015476 hypothetical protein; Provisional; Region: PRK10508 716540015477 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 716540015478 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 716540015479 Signal peptide predicted for EAM_3064 by SignalP 2.0 HMM (Signal peptide probability 0.947) with cleavage site probability 0.662 between residues 23 and 24 716540015480 HMMPfam hit to PF00296, Luciferase-like monooxygenase, score 3.7e-16 716540015481 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 716540015482 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 716540015483 ATP binding site [chemical binding]; other site 716540015484 Mg++ binding site [ion binding]; other site 716540015485 motif III; other site 716540015486 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 716540015487 nucleotide binding region [chemical binding]; other site 716540015488 ATP-binding site [chemical binding]; other site 716540015489 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 716540015490 putative RNA binding site [nucleotide binding]; other site 716540015491 HMMPfam hit to PF03880, DbpA RNA binding domain, score 1.3e-40 716540015492 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 1.9e-33 716540015493 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 8.6e-74 716540015494 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 716540015495 PS00017 ATP/GTP-binding site motif A (P-loop). 716540015496 lipoprotein NlpI; Provisional; Region: PRK11189 716540015497 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 716540015498 binding surface 716540015499 TPR motif; other site 716540015500 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 8.8e-06 716540015501 HMMPfam hit to PF00515, Tetratricopeptide repeat, score 0.00026 716540015502 Signal peptide predicted for EAM_3066 by SignalP 2.0 HMM (Signal peptide probability 0.971) with cleavage site probability 0.468 between residues 22 and 23 716540015503 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540015504 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 716540015505 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 716540015506 RNase E interface [polypeptide binding]; other site 716540015507 trimer interface [polypeptide binding]; other site 716540015508 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 716540015509 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 716540015510 RNase E interface [polypeptide binding]; other site 716540015511 trimer interface [polypeptide binding]; other site 716540015512 active site 716540015513 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 716540015514 RNA binding site [nucleotide binding]; other site 716540015515 domain interface; other site 716540015516 HMMPfam hit to PF00575, S1 RNA binding domain, score 3.2e-27 716540015517 HMMPfam hit to PF00013, KH domain, score 1.2e-14 716540015518 HMMPfam hit to PF03725, 3' exoribonuclease family, domain, score 6e-22 716540015519 HMMPfam hit to PF01138, 3' exoribonuclease family, domain, score 1.5e-54 716540015520 HMMPfam hit to PF03726, Polyribonucleotide nucleotidyltransferase,, score 2.5e-35 716540015521 HMMPfam hit to PF03725, 3' exoribonuclease family, domain, score 6.9e-18 716540015522 HMMPfam hit to PF01138, 3' exoribonuclease family, domain, score 1.9e-43 716540015523 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 716540015524 16S/18S rRNA binding site [nucleotide binding]; other site 716540015525 S13e-L30e interaction site [polypeptide binding]; other site 716540015526 25S rRNA binding site [nucleotide binding]; other site 716540015527 HMMPfam hit to PF00312, Ribosomal protein S15, score 8.5e-46 716540015528 PS00362 Ribosomal protein S15 signature. 716540015529 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 716540015530 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 716540015531 RNA binding site [nucleotide binding]; other site 716540015532 active site 716540015533 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 716540015534 HMMPfam hit to PF01509, TruB family pseudouridylate synthase (N term, score 9.3e-87 716540015535 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 716540015536 HMMPfam hit to PF02033, Ribosome-binding factor A, score 3e-58 716540015537 PS01319 Ribosome-binding factor A signature. 716540015538 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 716540015539 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 716540015540 translation initiation factor IF-2; Region: IF-2; TIGR00487 716540015541 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 716540015542 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 716540015543 G1 box; other site 716540015544 putative GEF interaction site [polypeptide binding]; other site 716540015545 GTP/Mg2+ binding site [chemical binding]; other site 716540015546 Switch I region; other site 716540015547 G2 box; other site 716540015548 G3 box; other site 716540015549 Switch II region; other site 716540015550 G4 box; other site 716540015551 G5 box; other site 716540015552 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 716540015553 Translation-initiation factor 2; Region: IF-2; pfam11987 716540015554 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 716540015555 HMMPfam hit to PF03144, Elongation factor Tu domain, score 3.4e-09 716540015556 PS01176 Initiation factor 2 signature. 716540015557 HMMPfam hit to PF03144, Elongation factor Tu domain, score 1.2e-10 716540015558 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 2.4e-56 716540015559 HMMPfam hit to PF01926, GTPase of unknown function, score 9.5e-07 716540015560 PS00017 ATP/GTP-binding site motif A (P-loop). 716540015561 HMMPfam hit to PF04760, Translation initiation factor IF-2, N-ter, score 1.2e-20 716540015562 HMMPfam hit to PF08364, Bacterial translation initiation factor I, score 1.4e-19 716540015563 HMMPfam hit to PF04760, Translation initiation factor IF-2, N-ter, score 2.8e-06 716540015564 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 716540015565 NusA N-terminal domain; Region: NusA_N; pfam08529 716540015566 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 716540015567 RNA binding site [nucleotide binding]; other site 716540015568 homodimer interface [polypeptide binding]; other site 716540015569 NusA-like KH domain; Region: KH_5; pfam13184 716540015570 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 716540015571 G-X-X-G motif; other site 716540015572 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 716540015573 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 716540015574 HMMPfam hit to PF00575, S1 RNA binding domain, score 0.00011 716540015575 HMMPfam hit to PF08529, NusA N-terminal domain, score 5.5e-65 716540015576 ribosome maturation protein RimP; Reviewed; Region: PRK00092 716540015577 Sm and related proteins; Region: Sm_like; cl00259 716540015578 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 716540015579 putative oligomer interface [polypeptide binding]; other site 716540015580 putative RNA binding site [nucleotide binding]; other site 716540015581 HMMPfam hit to PF02576, Uncharacterised BCR, YhbC family COG0779, score 4.4e-71 716540015582 Preprotein translocase SecG subunit; Region: SecG; pfam03840 716540015583 HMMPfam hit to PF03840, Preprotein translocase SecG subunit, score 2.8e-35 716540015584 2 transmembrane helices predicted for EAM_3074 by TMHMM2.0 at aa 5-22 and 51-73 716540015585 Signal peptide predicted for EAM_3074 by SignalP 2.0 HMM (Signal peptide probability 0.619) with cleavage site probability 0.230 between residues 38 and 39 716540015586 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 716540015587 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 716540015588 active site 716540015589 substrate binding site [chemical binding]; other site 716540015590 metal binding site [ion binding]; metal-binding site 716540015591 HMMPfam hit to PF00408, Phosphoglucomutase/phosphomannomutase, C-, score 1.1e-11 716540015592 HMMPfam hit to PF02880, Phosphoglucomutase/phosphomannomutase, al, score 1.8e-39 716540015593 HMMPfam hit to PF02879, Phosphoglucomutase/phosphomannomutase, al, score 1.2e-42 716540015594 HMMPfam hit to PF02878, Phosphoglucomutase/phosphomannomutase, al, score 2.4e-61 716540015595 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 716540015596 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 716540015597 dihydropteroate synthase; Region: DHPS; TIGR01496 716540015598 substrate binding pocket [chemical binding]; other site 716540015599 dimer interface [polypeptide binding]; other site 716540015600 inhibitor binding site; inhibition site 716540015601 HMMPfam hit to PF00809, Pterin binding enzyme, score 2.8e-102 716540015602 PS00793 Dihydropteroate synthase signature 2. 716540015603 PS00792 Dihydropteroate synthase signature 1. 716540015604 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 716540015605 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716540015606 Walker A motif; other site 716540015607 ATP binding site [chemical binding]; other site 716540015608 Walker B motif; other site 716540015609 arginine finger; other site 716540015610 Peptidase family M41; Region: Peptidase_M41; pfam01434 716540015611 HMMPfam hit to PF01434, Peptidase family M41, score 8.5e-128 716540015612 HMMPfam hit to PF00004, ATPase family associated with various c, score 3.6e-99 716540015613 HMMPfam hit to PF07728, ATPase family associated with various c, score 0.00011 716540015614 PS00674 AAA-protein family signature. 716540015615 PS00017 ATP/GTP-binding site motif A (P-loop). 716540015616 HMMPfam hit to PF06480, FtsH Extracellular, score 2e-50 716540015617 PS00017 ATP/GTP-binding site motif A (P-loop). 716540015618 2 transmembrane helices predicted for EAM_3078 by TMHMM2.0 at aa 5-24 and 97-119 716540015619 Signal peptide predicted for EAM_3078 by SignalP 2.0 HMM (Signal peptide probability 0.961) with cleavage site probability 0.634 between residues 23 and 24 716540015620 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 716540015621 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716540015622 S-adenosylmethionine binding site [chemical binding]; other site 716540015623 HMMPfam hit to PF01728, FtsJ-like methyltransferase, score 1.8e-81 716540015624 RNA-binding protein YhbY; Provisional; Region: PRK10343 716540015625 HMMPfam hit to PF01985, CRS1 / YhbY domain, score 1.2e-37 716540015626 PS01301 Uncharacterized protein family UPF0044 signature. 716540015627 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 716540015628 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 716540015629 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 716540015630 HMMPfam hit to PF01272, Prokaryotic transcription elongation fact, score 8.3e-39 716540015631 PS00830 Prokaryotic transcription elongation factors signature 2. 716540015632 HMMPfam hit to PF03449, Prokaryotic transcription elongation fact, score 1.7e-43 716540015633 PS00829 Prokaryotic transcription elongation factors signature 1. 716540015634 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 716540015635 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 716540015636 Signal peptide predicted for EAM_3082 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 20 and 21 716540015637 HMMPfam hit to PF02113, D-Ala-D-Ala carboxypeptidase 3 (S13) fa, score 5.5e-188 716540015638 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 716540015639 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716540015640 active site 716540015641 phosphorylation site [posttranslational modification] 716540015642 intermolecular recognition site; other site 716540015643 dimerization interface [polypeptide binding]; other site 716540015644 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 716540015645 DNA binding site [nucleotide binding] 716540015646 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.8e-40 716540015647 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 1.3e-20 716540015648 sensor protein BasS/PmrB; Provisional; Region: PRK10755 716540015649 HAMP domain; Region: HAMP; pfam00672 716540015650 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 716540015651 dimer interface [polypeptide binding]; other site 716540015652 phosphorylation site [posttranslational modification] 716540015653 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716540015654 ATP binding site [chemical binding]; other site 716540015655 Mg2+ binding site [ion binding]; other site 716540015656 G-X-G motif; other site 716540015657 Signal peptide predicted for EAM_3084 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.403 between residues 23 and 24 716540015658 2 transmembrane helices predicted for EAM_3084 by TMHMM2.0 at aa 7-29 and 64-86 716540015659 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540015660 HMMPfam hit to PF00672, HAMP domain, score 2.6e-07 716540015661 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 2e-11 716540015662 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 3.6e-23 716540015663 GTPase CgtA; Reviewed; Region: obgE; PRK12298 716540015664 GTP1/OBG; Region: GTP1_OBG; pfam01018 716540015665 Obg GTPase; Region: Obg; cd01898 716540015666 G1 box; other site 716540015667 GTP/Mg2+ binding site [chemical binding]; other site 716540015668 Switch I region; other site 716540015669 G2 box; other site 716540015670 G3 box; other site 716540015671 Switch II region; other site 716540015672 G4 box; other site 716540015673 G5 box; other site 716540015674 HMMPfam hit to PF01926, GTPase of unknown function, score 2e-36 716540015675 PS00905 GTP1/OBG family signature. 716540015676 PS00017 ATP/GTP-binding site motif A (P-loop). 716540015677 HMMPfam hit to PF01018, GTP1/OBG, score 9.6e-98 716540015678 3 transmembrane helices predicted for EAM_3086 by TMHMM2.0 at aa 5-27, 59-78 and 90-112 716540015679 Signal peptide predicted for EAM_3086 by SignalP 2.0 HMM (Signal peptide probability 0.974) with cleavage site probability 0.801 between residues 26 and 27 716540015680 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 716540015681 HMMPfam hit to PF01016, Ribosomal L27 protein, score 7.6e-55 716540015682 PS00831 Ribosomal protein L27 signature. 716540015683 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 716540015684 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 716540015685 HMMPfam hit to PF00829, Ribosomal prokaryotic L21 protein, score 2e-58 716540015686 PS01169 Ribosomal protein L21 signature. 716540015687 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 716540015688 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 716540015689 substrate binding pocket [chemical binding]; other site 716540015690 chain length determination region; other site 716540015691 substrate-Mg2+ binding site; other site 716540015692 catalytic residues [active] 716540015693 aspartate-rich region 1; other site 716540015694 active site lid residues [active] 716540015695 aspartate-rich region 2; other site 716540015696 HMMPfam hit to PF00348, Polyprenyl synthetase, score 4.2e-120 716540015697 PS00723 Polyprenyl synthetases signature 1. 716540015698 PS00444 Polyprenyl synthetases signature 2. 716540015699 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 716540015700 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 716540015701 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 716540015702 hinge; other site 716540015703 active site 716540015704 HMMPfam hit to PF00275, EPSP synthase (3-phosphoshikimate 1-car, score 1.8e-183 716540015705 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 716540015706 HMMPfam hit to PF01722, BolA-like protein, score 1.6e-34 716540015707 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 716540015708 anti sigma factor interaction site; other site 716540015709 regulatory phosphorylation site [posttranslational modification]; other site 716540015710 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 716540015711 HMMPfam hit to PF05494, Toluene tolerance, Ttg2, score 1.7e-93 716540015712 Signal peptide predicted for EAM_3094 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.967 between residues 20 and 21 716540015713 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 716540015714 mce related protein; Region: MCE; pfam02470 716540015715 HMMPfam hit to PF02470, mce related protein, score 2.2e-22 716540015716 1 transmembrane helix predicted for EAM_3095 by TMHMM2.0 at aa 7-29 716540015717 Signal peptide predicted for EAM_3095 by SignalP 2.0 HMM (Signal peptide probability 0.939) with cleavage site probability 0.624 between residues 27 and 28 716540015718 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 716540015719 conserved hypothetical integral membrane protein; Region: TIGR00056 716540015720 5 transmembrane helices predicted for EAM_3096 by TMHMM2.0 at aa 13-35, 50-72, 148-177, 197-219 and 239-258 716540015721 HMMPfam hit to PF02405, Domain of unknown function DUF140, score 4.2e-123 716540015722 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 716540015723 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 716540015724 Walker A/P-loop; other site 716540015725 ATP binding site [chemical binding]; other site 716540015726 Q-loop/lid; other site 716540015727 ABC transporter signature motif; other site 716540015728 Walker B; other site 716540015729 D-loop; other site 716540015730 H-loop/switch region; other site 716540015731 HMMPfam hit to PF00005, ABC transporter, score 8.4e-54 716540015732 PS00211 ABC transporters family signature. 716540015733 PS00017 ATP/GTP-binding site motif A (P-loop). 716540015734 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 716540015735 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 716540015736 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 716540015737 Signal peptide predicted for EAM_3098 by SignalP 2.0 HMM (Signal peptide probability 0.908) with cleavage site probability 0.844 between residues 18 and 19 716540015738 9 transmembrane helices predicted for EAM_3098 by TMHMM2.0 at aa 7-29, 39-61, 68-90, 129-146, 174-196, 211-233, 240-262, 277-294 and 301-323 716540015739 HMMPfam hit to PF01699, Sodium/calcium exchanger protein, score 9.1e-44 716540015740 HMMPfam hit to PF01699, Sodium/calcium exchanger protein, score 7.9e-37 716540015741 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 716540015742 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 716540015743 putative active site [active] 716540015744 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 716540015745 HMMPfam hit to PF01380, SIS domain, score 4.3e-39 716540015746 HMMPfam hit to PF00571, CBS domain pair, score 6.3e-20 716540015747 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 716540015748 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 716540015749 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 716540015750 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 716540015751 Signal peptide predicted for EAM_3101 by SignalP 2.0 HMM (Signal peptide probability 0.889) with cleavage site probability 0.423 between residues 23 and 24 716540015752 1 transmembrane helix predicted for EAM_3101 by TMHMM2.0 at aa 7-24 716540015753 HMMPfam hit to PF06835, Protein of unknown function (DUF1239), score 2.7e-67 716540015754 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 716540015755 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 716540015756 Signal peptide predicted for EAM_3102 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.992 between residues 23 and 24 716540015757 HMMPfam hit to PF03968, OstA-like protein, score 2.3e-56 716540015758 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 716540015759 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 716540015760 Walker A/P-loop; other site 716540015761 ATP binding site [chemical binding]; other site 716540015762 Q-loop/lid; other site 716540015763 ABC transporter signature motif; other site 716540015764 Walker B; other site 716540015765 D-loop; other site 716540015766 H-loop/switch region; other site 716540015767 HMMPfam hit to PF00005, ABC transporter, score 1.3e-56 716540015768 PS00017 ATP/GTP-binding site motif A (P-loop). 716540015769 PS00211 ABC transporters family signature. 716540015770 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 716540015771 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 716540015772 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 716540015773 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 716540015774 HMMPfam hit to PF00309, Sigma-54 factor, Activator interacting do, score 4.2e-19 716540015775 PS00041 Bacterial regulatory proteins, araC family signature. 716540015776 HMMPfam hit to PF04963, Sigma-54 factor, core binding domain, score 2e-107 716540015777 HMMPfam hit to PF04552, Sigma-54, DNA binding domain, score 4e-106 716540015778 PS00717 Sigma-54 factors family signature 1. 716540015779 PS00718 Sigma-54 factors family signature 2. 716540015780 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 716540015781 30S subunit binding site; other site 716540015782 HMMPfam hit to PF02482, Sigma 54 modulation protein / S30EA r, score 9.1e-50 716540015783 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 716540015784 active site 716540015785 phosphorylation site [posttranslational modification] 716540015786 HMMPfam hit to PF00359, Phosphoenolpyruvate-dependent sugar phosph, score 3.7e-53 716540015787 PS00372 PTS EIIA domains phosphorylation site signature 2. 716540015788 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 716540015789 HMMPfam hit to PF03668, P-loop ATPase family, score 5.5e-207 716540015790 PS00017 ATP/GTP-binding site motif A (P-loop). 716540015791 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 716540015792 dimerization domain swap beta strand [polypeptide binding]; other site 716540015793 regulatory protein interface [polypeptide binding]; other site 716540015794 active site 716540015795 regulatory phosphorylation site [posttranslational modification]; other site 716540015796 HMMPfam hit to PF00381, PTS HPr component phosphorylation site, score 1.4e-34 716540015797 PS00369 PTS HPR component histidine phosphorylation site signature. 716540015798 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 716540015799 Transglycosylase; Region: Transgly; cl17702 716540015800 HMMPfam hit to PF00912, Transglycosylase, score 1.1e-66 716540015801 1 transmembrane helix predicted for EAM_3109 by TMHMM2.0 at aa 19-41 716540015802 Signal peptide predicted for EAM_3109 by SignalP 2.0 HMM (Signal peptide probability 0.927) with cleavage site probability 0.537 between residues 35 and 36 716540015803 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 716540015804 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 716540015805 putative active site [active] 716540015806 heme pocket [chemical binding]; other site 716540015807 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 716540015808 dimer interface [polypeptide binding]; other site 716540015809 phosphorylation site [posttranslational modification] 716540015810 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716540015811 ATP binding site [chemical binding]; other site 716540015812 Mg2+ binding site [ion binding]; other site 716540015813 G-X-G motif; other site 716540015814 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716540015815 active site 716540015816 phosphorylation site [posttranslational modification] 716540015817 intermolecular recognition site; other site 716540015818 dimerization interface [polypeptide binding]; other site 716540015819 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 716540015820 putative binding surface; other site 716540015821 active site 716540015822 HMMPfam hit to PF01627, Hpt domain, score 6.2e-16 716540015823 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.4e-30 716540015824 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 7.3e-37 716540015825 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 9.6e-19 716540015826 HMMPfam hit to PF08448, PAS fold, score 2.1e-15 716540015827 HMMPfam hit to PF00989, PAS fold, score 3e-25 716540015828 2 transmembrane helices predicted for EAM_3110 by TMHMM2.0 at aa 20-42 and 55-77 716540015829 Signal peptide predicted for EAM_3110 by SignalP 2.0 HMM (Signal peptide probability 0.941) with cleavage site probability 0.323 between residues 40 and 41 716540015830 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 716540015831 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 716540015832 active site 716540015833 dimer interface [polypeptide binding]; other site 716540015834 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 716540015835 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 716540015836 active site 716540015837 FMN binding site [chemical binding]; other site 716540015838 substrate binding site [chemical binding]; other site 716540015839 3Fe-4S cluster binding site [ion binding]; other site 716540015840 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 716540015841 domain_subunit interface; other site 716540015842 HMMPfam hit to PF00310, Glutamine amidotransferases class-II, score 2e-65 716540015843 HMMPfam hit to PF04898, Glutamate synthase central domain, score 6.4e-44 716540015844 HMMPfam hit to PF01645, Conserved region in glutamate synthas, score 2.6e-114 716540015845 HMMPfam hit to PF01493, GXGXG motif, score 7.9e-45 716540015846 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 716540015847 Flavodoxin; Region: Flavodoxin_1; pfam00258 716540015848 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 716540015849 FAD binding pocket [chemical binding]; other site 716540015850 FAD binding motif [chemical binding]; other site 716540015851 catalytic residues [active] 716540015852 NAD binding pocket [chemical binding]; other site 716540015853 phosphate binding motif [ion binding]; other site 716540015854 beta-alpha-beta structure motif; other site 716540015855 HMMPfam hit to PF00258, Flavodoxin, score 1.7e-40 716540015856 HMMPfam hit to PF00667, FAD binding domain, score 2e-37 716540015857 HMMPfam hit to PF00175, Oxidoreductase NAD-binding domain, score 2e-29 716540015858 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 716540015859 HMMPfam hit to PF04386, Stringent starvation protein B, score 3.4e-82 716540015860 stringent starvation protein A; Provisional; Region: sspA; PRK09481 716540015861 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 716540015862 C-terminal domain interface [polypeptide binding]; other site 716540015863 putative GSH binding site (G-site) [chemical binding]; other site 716540015864 dimer interface [polypeptide binding]; other site 716540015865 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 716540015866 dimer interface [polypeptide binding]; other site 716540015867 N-terminal domain interface [polypeptide binding]; other site 716540015868 HMMPfam hit to PF00043, Glutathione S-transferase, C-terminal domain, score 2e-13 716540015869 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal domain, score 4.8e-22 716540015870 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 716540015871 HMMPfam hit to PF00380, Ribosomal protein S9/S16, score 6.1e-74 716540015872 PS00360 Ribosomal protein S9 signature. 716540015873 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 716540015874 23S rRNA interface [nucleotide binding]; other site 716540015875 L3 interface [polypeptide binding]; other site 716540015876 HMMPfam hit to PF00572, Ribosomal protein L13, score 5.8e-88 716540015877 PS00783 Ribosomal protein L13 signature. 716540015878 Predicted ATPase [General function prediction only]; Region: COG1485 716540015879 HMMPfam hit to PF03969, AFG1-like ATPase, score 1.9e-191 716540015880 PS00017 ATP/GTP-binding site motif A (P-loop). 716540015881 hypothetical protein; Provisional; Region: PRK11677 716540015882 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 716540015883 HMMPfam hit to PF06295, Protein of unknown function (DUF1043), score 4.4e-71 716540015884 1 transmembrane helix predicted for EAM_3118 by TMHMM2.0 at aa 5-24 716540015885 serine endoprotease; Provisional; Region: PRK10139 716540015886 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 716540015887 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 716540015888 protein binding site [polypeptide binding]; other site 716540015889 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 716540015890 protein binding site [polypeptide binding]; other site 716540015891 Signal peptide predicted for EAM_3119 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.371 between residues 26 and 27 716540015892 1 transmembrane helix predicted for EAM_3119 by TMHMM2.0 at aa 7-29 716540015893 HMMPfam hit to PF00089, Trypsin, score 1.5e-18 716540015894 HMMPfam hit to PF00595, PDZ domain (Also known as DHR or GLGF), score 1.5e-15 716540015895 HMMPfam hit to PF00595, PDZ domain (Also known as DHR or GLGF), score 2.2e-08 716540015896 serine endoprotease; Provisional; Region: PRK10898 716540015897 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 716540015898 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 716540015899 protein binding site [polypeptide binding]; other site 716540015900 Signal peptide predicted for EAM_3120 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.831 between residues 29 and 30 716540015901 1 transmembrane helix predicted for EAM_3120 by TMHMM2.0 at aa 5-24 716540015902 HMMPfam hit to PF00089, Trypsin, score 2e-19 716540015903 HMMPfam hit to PF00595, PDZ domain (Also known as DHR or GLGF), score 2.6e-11 716540015904 malate dehydrogenase; Provisional; Region: PRK05086 716540015905 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 716540015906 NAD binding site [chemical binding]; other site 716540015907 dimerization interface [polypeptide binding]; other site 716540015908 Substrate binding site [chemical binding]; other site 716540015909 HMMPfam hit to PF02866, lactate/malate dehydrogenase, alpha/beta C-t, score 4.3e-70 716540015910 PS00068 Malate dehydrogenase active site signature. 716540015911 HMMPfam hit to PF00056, lactate/malate dehydrogenase, NAD binding do, score 1.1e-68 716540015912 Signal peptide predicted for EAM_3121 by SignalP 2.0 HMM (Signal peptide probability 0.803) with cleavage site probability 0.736 between residues 17 and 18 716540015913 arginine repressor; Provisional; Region: PRK05066 716540015914 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 716540015915 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 716540015916 HMMPfam hit to PF01316, Arginine repressor, DNA binding domai, score 7.2e-30 716540015917 HMMPfam hit to PF02863, Arginine repressor, C-terminal domain, score 3.1e-25 716540015918 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 716540015919 HMMPfam hit to PF07338, Protein of unknown function (DUF1471), score 9.2e-44 716540015920 Signal peptide predicted for EAM_3123 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.960 between residues 22 and 23 716540015921 1 transmembrane helix predicted for EAM_3123 by TMHMM2.0 at aa 7-26 716540015922 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 716540015923 HMMPfam hit to PF07338, Protein of unknown function (DUF1471), score 2.5e-40 716540015924 Signal peptide predicted for EAM_3124 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.975 between residues 22 and 23 716540015925 1 transmembrane helix predicted for EAM_3124 by TMHMM2.0 at aa 4-26 716540015926 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 716540015927 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 716540015928 10 transmembrane helices predicted for EAM_3125 by TMHMM2.0 at aa 7-29, 33-55, 62-84, 88-107, 114-136, 369-391, 404-422, 426-448, 453-468 and 483-500 716540015929 HMMPfam hit to PF04632, Fusaric acid resistance protein conserved re, score 4.2e-33 716540015930 PS00237 G-protein coupled receptors signature. 716540015931 Signal peptide predicted for EAM_3125 by SignalP 2.0 HMM (Signal peptide probability 0.975) with cleavage site probability 0.909 between residues 27 and 28 716540015932 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 716540015933 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 716540015934 HlyD family secretion protein; Region: HlyD_3; pfam13437 716540015935 HMMPfam hit to PF00529, HlyD family secretion protein, score 1.7e-37 716540015936 1 transmembrane helix predicted for EAM_3126 by TMHMM2.0 at aa 12-31 716540015937 Signal peptide predicted for EAM_3126 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.292 between residues 30 and 31 716540015938 efflux system membrane protein; Provisional; Region: PRK11594 716540015939 HMMPfam hit to PF07869, Protein of unknown function (DUF1656), score 1.1e-20 716540015940 2 transmembrane helices predicted for EAM_3127 by TMHMM2.0 at aa 7-29 and 44-63 716540015941 transcriptional regulator; Provisional; Region: PRK10632 716540015942 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716540015943 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 716540015944 putative effector binding pocket; other site 716540015945 dimerization interface [polypeptide binding]; other site 716540015946 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 3.8e-18 716540015947 PS00044 Bacterial regulatory proteins, lysR family signature. 716540015948 HMMPfam hit to PF03466, LysR substrate binding domain, score 2e-46 716540015949 protease TldD; Provisional; Region: tldD; PRK10735 716540015950 HMMPfam hit to PF01523, modulator of DNA gyrase, score 4.9e-106 716540015951 PS00152 ATP synthase alpha and beta subunits signature. 716540015952 hypothetical protein; Provisional; Region: PRK10899 716540015953 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 716540015954 PS00141 Eukaryotic and viral aspartyl proteases active site. 716540015955 1 transmembrane helix predicted for EAM_3130 by TMHMM2.0 at aa 7-29 716540015956 Signal peptide predicted for EAM_3130 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.669 between residues 25 and 26 716540015957 ribonuclease G; Provisional; Region: PRK11712 716540015958 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 716540015959 homodimer interface [polypeptide binding]; other site 716540015960 oligonucleotide binding site [chemical binding]; other site 716540015961 HMMPfam hit to PF00575, S1 RNA binding domain, score 3.7e-19 716540015962 Maf-like protein; Region: Maf; pfam02545 716540015963 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 716540015964 active site 716540015965 dimer interface [polypeptide binding]; other site 716540015966 HMMPfam hit to PF02545, Maf-like protein, score 9.7e-80 716540015967 rod shape-determining protein MreD; Provisional; Region: PRK11060 716540015968 HMMPfam hit to PF04093, rod shape-determining protein MreD, score 9.9e-55 716540015969 4 transmembrane helices predicted for EAM_3133 by TMHMM2.0 at aa 31-53, 68-90, 97-119 and 134-151 716540015970 rod shape-determining protein MreC; Region: mreC; TIGR00219 716540015971 rod shape-determining protein MreC; Region: MreC; pfam04085 716540015972 HMMPfam hit to PF04085, rod shape-determining protein MreC, score 8.1e-69 716540015973 Signal peptide predicted for EAM_3134 by SignalP 2.0 HMM (Signal peptide probability 0.950) with cleavage site probability 0.492 between residues 36 and 37 716540015974 1 transmembrane helix predicted for EAM_3134 by TMHMM2.0 at aa 13-35 716540015975 rod shape-determining protein MreB; Provisional; Region: PRK13927 716540015976 MreB and similar proteins; Region: MreB_like; cd10225 716540015977 nucleotide binding site [chemical binding]; other site 716540015978 Mg binding site [ion binding]; other site 716540015979 putative protofilament interaction site [polypeptide binding]; other site 716540015980 RodZ interaction site [polypeptide binding]; other site 716540015981 HMMPfam hit to PF06723, MreB/Mbl protein, score 4.1e-237 716540015982 regulatory protein CsrD; Provisional; Region: PRK11059 716540015983 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 716540015984 metal binding site [ion binding]; metal-binding site 716540015985 active site 716540015986 I-site; other site 716540015987 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 716540015988 HMMPfam hit to PF00563, EAL domain, score 1.8e-31 716540015989 HMMPfam hit to PF00990, GGDEF domain, score 1.5e-21 716540015990 2 transmembrane helices predicted for EAM_3136 by TMHMM2.0 at aa 10-32 and 130-152 716540015991 Signal peptide predicted for EAM_3136 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.359 between residues 34 and 35 716540015992 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540015993 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 716540015994 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 716540015995 NADP binding site [chemical binding]; other site 716540015996 dimer interface [polypeptide binding]; other site 716540015997 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like domain, score 6.8e-09 716540015998 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 6.1e-20 716540015999 TMAO/DMSO reductase; Reviewed; Region: PRK05363 716540016000 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 716540016001 Moco binding site; other site 716540016002 metal coordination site [ion binding]; other site 716540016003 Signal peptide predicted for EAM_3138 by SignalP 2.0 HMM (Signal peptide probability 0.976) with cleavage site probability 0.968 between residues 44 and 45 716540016004 HMMPfam hit to PF00174, Oxidoreductase molybdopterin binding d, score 1.4e-66 716540016005 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 716540016006 Signal peptide predicted for EAM_3139 by SignalP 2.0 HMM (Signal peptide probability 0.810) with cleavage site probability 0.605 between residues 37 and 38 716540016007 6 transmembrane helices predicted for EAM_3139 by TMHMM2.0 at aa 12-31, 46-68, 81-103, 118-137, 150-168 and 178-192 716540016008 HMMPfam hit to PF01794, Ferric reductase like transmembrane com, score 3.1e-29 716540016009 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 716540016010 Dehydroquinase class II; Region: DHquinase_II; pfam01220 716540016011 active site 716540016012 trimer interface [polypeptide binding]; other site 716540016013 dimer interface [polypeptide binding]; other site 716540016014 HMMPfam hit to PF01220, Dehydroquinase class II, score 3.1e-86 716540016015 PS01029 Dehydroquinase class II signature. 716540016016 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 716540016017 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 716540016018 carboxyltransferase (CT) interaction site; other site 716540016019 biotinylation site [posttranslational modification]; other site 716540016020 HMMPfam hit to PF00364, Biotin-requiring enzyme, score 7.8e-36 716540016021 PS00188 Biotin-requiring enzymes attachment site. 716540016022 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 716540016023 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 716540016024 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 716540016025 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 716540016026 HMMPfam hit to PF00289, Carbamoyl-phosphate synthase L chain,, score 1.5e-53 716540016027 HMMPfam hit to PF08443, RimK-like ATP-grasp domain, score 0.0023 716540016028 HMMPfam hit to PF01071, Phosphoribosylglycinamide synthetase,, score 0.002 716540016029 HMMPfam hit to PF02786, Carbamoyl-phosphate synthase L chain,, score 4.7e-125 716540016030 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 716540016031 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 716540016032 HMMPfam hit to PF02785, Biotin carboxylase C-terminal domain, score 5.9e-63 716540016033 hypothetical protein; Provisional; Region: PRK10633 716540016034 Signal peptide predicted for EAM_3143 by SignalP 2.0 HMM (Signal peptide probability 0.646) with cleavage site probability 0.436 between residues 32 and 33 716540016035 HMMPfam hit to PF06196, Protein of unknown function (DUF997), score 8.2e-33 716540016036 2 transmembrane helices predicted for EAM_3143 by TMHMM2.0 at aa 13-32 and 47-69 716540016037 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 716540016038 Na binding site [ion binding]; other site 716540016039 Signal peptide predicted for EAM_3144 by SignalP 2.0 HMM (Signal peptide probability 0.893) with cleavage site probability 0.884 between residues 23 and 24 716540016040 13 transmembrane helices predicted for EAM_3144 by TMHMM2.0 at aa 5-24, 37-59, 72-94, 123-145, 160-182, 189-211, 233-255, 268-290, 305-327, 369-386, 391-413, 420-442 and 447-466 716540016041 HMMPfam hit to PF00474, Sodium:solute symporter family, score 2.5e-174 716540016042 PS00456 Sodium:solute symporter family signature 1. 716540016043 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 716540016044 HMMPfam hit to PF06325, Ribosomal protein L11 methyltransfera, score 2.6e-161 716540016045 HMMPfam hit to PF05175, Methyltransferase small domain, score 8.3e-05 716540016046 PS00017 ATP/GTP-binding site motif A (P-loop). 716540016047 HMMPfam hit to PF08242, Methyltransferase domain, score 2.8e-05 716540016048 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 716540016049 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 716540016050 FMN binding site [chemical binding]; other site 716540016051 active site 716540016052 catalytic residues [active] 716540016053 substrate binding site [chemical binding]; other site 716540016054 HMMPfam hit to PF01207, Dihydrouridine synthase (Dus), score 7.9e-156 716540016055 PS01136 Uncharacterized protein family UPF0034 signature. 716540016056 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 716540016057 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 716540016058 HMMPfam hit to PF02954, Bacterial regulatory protein, Fis family, score 4.4e-15 716540016059 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 716540016060 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 716540016061 putative acyl-acceptor binding pocket; other site 716540016062 HMMPfam hit to PF03279, Bacterial lipid A biosynthesis acyltr, score 4e-127 716540016063 1 transmembrane helix predicted for EAM_3150 by TMHMM2.0 at aa 16-38 716540016064 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 716540016065 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 716540016066 substrate binding pocket [chemical binding]; other site 716540016067 membrane-bound complex binding site; other site 716540016068 hinge residues; other site 716540016069 Signal peptide predicted for EAM_3151 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.993 between residues 24 and 25 716540016070 HMMPfam hit to PF00497, Bacterial extracellular solute-binding prot, score 1.3e-12 716540016071 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 716540016072 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 716540016073 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540016074 conserved gate region; other site 716540016075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540016076 dimer interface [polypeptide binding]; other site 716540016077 conserved gate region; other site 716540016078 putative PBP binding loops; other site 716540016079 ABC-ATPase subunit interface; other site 716540016080 7 transmembrane helices predicted for EAM_3152 by TMHMM2.0 at aa 20-39, 91-113, 177-199, 212-234, 254-276, 333-352 and 362-384 716540016081 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 2.6e-18 716540016082 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 716540016083 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540016084 dimer interface [polypeptide binding]; other site 716540016085 conserved gate region; other site 716540016086 putative PBP binding loops; other site 716540016087 ABC-ATPase subunit interface; other site 716540016088 8 transmembrane helices predicted for EAM_3153 by TMHMM2.0 at aa 28-50, 99-117, 124-146, 161-183, 195-217, 232-251, 291-313 and 328-350 716540016089 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 4.9e-31 716540016090 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 716540016091 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 716540016092 Walker A/P-loop; other site 716540016093 ATP binding site [chemical binding]; other site 716540016094 Q-loop/lid; other site 716540016095 ABC transporter signature motif; other site 716540016096 Walker B; other site 716540016097 D-loop; other site 716540016098 H-loop/switch region; other site 716540016099 HMMPfam hit to PF00005, ABC transporter, score 1.9e-63 716540016100 PS00017 ATP/GTP-binding site motif A (P-loop). 716540016101 PS00211 ABC transporters family signature. 716540016102 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 716540016103 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 716540016104 trimer interface [polypeptide binding]; other site 716540016105 putative metal binding site [ion binding]; other site 716540016106 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 11 716540016107 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 73 716540016108 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 14 716540016109 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 1.2 716540016110 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 18 716540016111 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 716540016112 HMMPfam hit to PF07369, Protein of unknown function (DUF1488), score 2.3e-29 716540016113 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 716540016114 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 716540016115 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 716540016116 shikimate binding site; other site 716540016117 NAD(P) binding site [chemical binding]; other site 716540016118 HMMPfam hit to PF01488, Shikimate / quinate 5-dehydrogenase, score 3.2e-27 716540016119 HMMPfam hit to PF08501, Shikimate dehydrogenase substrate bind, score 6.4e-31 716540016120 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 716540016121 HMMPfam hit to PF01300, yrdC domain, score 4.7e-70 716540016122 PS01147 SUA5/yciO/yrdC family signature. 716540016123 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 716540016124 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 716540016125 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 716540016126 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 716540016127 HMMPfam hit to PF01396, Topoisomerase DNA binding C4 zinc fing, score 3.2e-12 716540016128 HMMPfam hit to PF01396, Topoisomerase DNA binding C4 zinc fing, score 2.3e-19 716540016129 HMMPfam hit to PF01396, Topoisomerase DNA binding C4 zinc fing, score 4.3e-16 716540016130 hypothetical protein; Validated; Region: PRK03430 716540016131 HMMPfam hit to PF04361, Protein of unknown function (DUF494), score 1.4e-109 716540016132 hypothetical protein; Provisional; Region: PRK10736 716540016133 DNA protecting protein DprA; Region: dprA; TIGR00732 716540016134 HMMPfam hit to PF02481, SMF family, score 4.7e-106 716540016135 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 716540016136 active site 716540016137 catalytic residues [active] 716540016138 metal binding site [ion binding]; metal-binding site 716540016139 HMMPfam hit to PF01327, Polypeptide deformylase, score 1.5e-83 716540016140 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 716540016141 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 716540016142 putative active site [active] 716540016143 substrate binding site [chemical binding]; other site 716540016144 putative cosubstrate binding site; other site 716540016145 catalytic site [active] 716540016146 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 716540016147 substrate binding site [chemical binding]; other site 716540016148 HMMPfam hit to PF00551, Formyl transferase, score 1.6e-78 716540016149 HMMPfam hit to PF02911, Formyl transferase, C-terminal domain, score 4.7e-45 716540016150 16S rRNA methyltransferase B; Provisional; Region: PRK10901 716540016151 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 716540016152 putative RNA binding site [nucleotide binding]; other site 716540016153 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716540016154 S-adenosylmethionine binding site [chemical binding]; other site 716540016155 HMMPfam hit to PF01029, NusB family, score 2.9e-40 716540016156 HMMPfam hit to PF01189, NOL1/NOP2/sun family, score 2.2e-119 716540016157 PS01153 NOL1/NOP2/sun family signature. 716540016158 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 716540016159 TrkA-N domain; Region: TrkA_N; pfam02254 716540016160 TrkA-C domain; Region: TrkA_C; pfam02080 716540016161 TrkA-N domain; Region: TrkA_N; pfam02254 716540016162 TrkA-C domain; Region: TrkA_C; pfam02080 716540016163 HMMPfam hit to PF02254, TrkA-N domain, score 7.1e-35 716540016164 HMMPfam hit to PF02080, TrkA-C domain, score 7.4e-10 716540016165 HMMPfam hit to PF02254, TrkA-N domain, score 2.1e-34 716540016166 HMMPfam hit to PF02080, TrkA-C domain, score 1.1e-13 716540016167 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 716540016168 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 716540016169 HMMPfam hit to PF01741, Large-conductance mechanosensitive channel,, score 9.2e-77 716540016170 PS01327 Large-conductance mechanosensitive channels mscL family signature. 716540016171 2 transmembrane helices predicted for EAM_3166 by TMHMM2.0 at aa 20-42 and 77-96 716540016172 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 716540016173 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 716540016174 HMMPfam hit to PF03889, Domain of unknown function, score 1.7e-21 716540016175 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 716540016176 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 716540016177 DNA binding residues [nucleotide binding] 716540016178 dimer interface [polypeptide binding]; other site 716540016179 metal binding site [ion binding]; metal-binding site 716540016180 HMMPfam hit to PF00376, MerR family regulatory protein, score 1.7e-08 716540016181 PS00552 Bacterial regulatory proteins, merR family signature. 716540016182 hypothetical protein; Provisional; Region: PRK10203 716540016183 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 716540016184 HMMPfam hit to PF01196, Ribosomal protein L17, score 6.1e-67 716540016185 PS01167 Ribosomal protein L17 signature. 716540016186 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 716540016187 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 716540016188 alphaNTD homodimer interface [polypeptide binding]; other site 716540016189 alphaNTD - beta interaction site [polypeptide binding]; other site 716540016190 alphaNTD - beta' interaction site [polypeptide binding]; other site 716540016191 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 716540016192 HMMPfam hit to PF03118, Bacterial RNA polymerase, alpha chain C, score 1.9e-35 716540016193 HMMPfam hit to PF01193, RNA polymerase Rpb3/Rpb11 dimerisation, score 1.4e-23 716540016194 HMMPfam hit to PF01000, RNA polymerase Rpb3/RpoA insert domain, score 4.2e-58 716540016195 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 716540016196 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 716540016197 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 716540016198 RNA binding surface [nucleotide binding]; other site 716540016199 HMMPfam hit to PF01479, S4 domain, score 2.1e-20 716540016200 PS00632 Ribosomal protein S4 signature. 716540016201 HMMPfam hit to PF00163, Ribosomal protein S4/S9 N-terminal domai, score 1.1e-37 716540016202 30S ribosomal protein S11; Validated; Region: PRK05309 716540016203 HMMPfam hit to PF00411, Ribosomal protein S11, score 1.3e-75 716540016204 PS00054 Ribosomal protein S11 signature. 716540016205 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 716540016206 30S ribosomal protein S13; Region: bact_S13; TIGR03631 716540016207 HMMPfam hit to PF00416, Ribosomal protein S13/S18, score 9.4e-60 716540016208 PS00646 Ribosomal protein S13 signature. 716540016209 PS00017 ATP/GTP-binding site motif A (P-loop). 716540016210 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 716540016211 HMMPfam hit to PF00444, Ribosomal protein L36, score 1.6e-16 716540016212 PS00828 Ribosomal protein L36 signature. 716540016213 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 716540016214 SecY translocase; Region: SecY; pfam00344 716540016215 10 transmembrane helices predicted for EAM_3178 by TMHMM2.0 at aa 22-44, 76-98, 119-138, 153-175, 182-204, 215-237, 274-296, 316-338, 369-391 and 401-423 716540016216 HMMPfam hit to PF00344, eubacterial secY protein, score 3e-210 716540016217 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. 716540016218 PS00756 Protein secY signature 2. 716540016219 PS00755 Protein secY signature 1. 716540016220 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 716540016221 HMMPfam hit to PF00256, Ribosomal protein L15, score 1.4e-09 716540016222 PS00475 Ribosomal protein L15 signature. 716540016223 HMMPfam hit to PF01305, Ribosomal protein L15 amino terminal re, score 4.2e-55 716540016224 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 716540016225 23S rRNA binding site [nucleotide binding]; other site 716540016226 HMMPfam hit to PF00327, Ribosomal protein L30p/L7e, score 3.3e-25 716540016227 PS00634 Ribosomal protein L30 signature. 716540016228 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 716540016229 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 716540016230 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 716540016231 HMMPfam hit to PF03719, Ribosomal protein S5, C-terminal domai, score 2.4e-41 716540016232 HMMPfam hit to PF00333, Ribosomal protein S5, N-terminal domai, score 1.1e-40 716540016233 PS00585 Ribosomal protein S5 signature. 716540016234 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 716540016235 23S rRNA interface [nucleotide binding]; other site 716540016236 5S rRNA interface [nucleotide binding]; other site 716540016237 L27 interface [polypeptide binding]; other site 716540016238 L5 interface [polypeptide binding]; other site 716540016239 HMMPfam hit to PF00861, Ribosomal L18p/L5e family, score 3.8e-51 716540016240 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 716540016241 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 716540016242 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 716540016243 HMMPfam hit to PF00347, Ribosomal protein L6, score 5.9e-30 716540016244 PS00525 Ribosomal protein L6 signature 1. 716540016245 HMMPfam hit to PF00347, Ribosomal protein L6, score 1.4e-20 716540016246 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 716540016247 HMMPfam hit to PF00410, Ribosomal protein S8, score 2.1e-71 716540016248 PS00294 Prenyl group binding site (CAAX box). 716540016249 PS00053 Ribosomal protein S8 signature. 716540016250 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 716540016251 HMMPfam hit to PF00253, Ribosomal protein S14p/S29e, score 1.2e-25 716540016252 PS00527 Ribosomal protein S14 signature. 716540016253 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 716540016254 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 716540016255 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 716540016256 HMMPfam hit to PF00673, ribosomal L5P family C-terminus, score 6.8e-60 716540016257 HMMPfam hit to PF00281, Ribosomal protein L5, score 9.8e-34 716540016258 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 716540016259 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 716540016260 RNA binding site [nucleotide binding]; other site 716540016261 HMMPfam hit to PF00467, KOW motif, score 6.8e-07 716540016262 PS01108 Ribosomal protein L24 signature. 716540016263 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 716540016264 HMMPfam hit to PF00238, Ribosomal protein L14p/L23e, score 1.2e-80 716540016265 PS00049 Ribosomal protein L14 signature. 716540016266 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 716540016267 HMMPfam hit to PF00366, Ribosomal protein S17, score 1.1e-41 716540016268 PS00056 Ribosomal protein S17 signature. 716540016269 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 716540016270 23S rRNA interface [nucleotide binding]; other site 716540016271 putative translocon interaction site; other site 716540016272 signal recognition particle (SRP54) interaction site; other site 716540016273 L23 interface [polypeptide binding]; other site 716540016274 trigger factor interaction site; other site 716540016275 HMMPfam hit to PF00831, Ribosomal L29 protein, score 2.2e-28 716540016276 PS00579 Ribosomal protein L29 signature. 716540016277 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 716540016278 23S rRNA interface [nucleotide binding]; other site 716540016279 5S rRNA interface [nucleotide binding]; other site 716540016280 putative antibiotic binding site [chemical binding]; other site 716540016281 L25 interface [polypeptide binding]; other site 716540016282 L27 interface [polypeptide binding]; other site 716540016283 HMMPfam hit to PF00252, Ribosomal protein L16, score 5.6e-93 716540016284 PS00701 Ribosomal protein L16 signature 2. 716540016285 PS00586 Ribosomal protein L16 signature 1. 716540016286 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 716540016287 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 716540016288 G-X-X-G motif; other site 716540016289 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 716540016290 HMMPfam hit to PF00189, Ribosomal protein S3, C-terminal domai, score 7.3e-54 716540016291 PS00548 Ribosomal protein S3 signature. 716540016292 HMMPfam hit to PF07650, KH domain, score 2e-19 716540016293 HMMPfam hit to PF00417, Ribosomal protein S3, N-terminal domai, score 7.3e-29 716540016294 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 716540016295 protein-rRNA interface [nucleotide binding]; other site 716540016296 putative translocon binding site; other site 716540016297 HMMPfam hit to PF00237, Ribosomal protein L22p/L17e, score 2.3e-59 716540016298 PS00464 Ribosomal protein L22 signature. 716540016299 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 716540016300 HMMPfam hit to PF00203, Ribosomal protein S19, score 3.9e-53 716540016301 PS00323 Ribosomal protein S19 signature. 716540016302 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 716540016303 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 716540016304 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 716540016305 HMMPfam hit to PF03947, Ribosomal Proteins L2, C-terminal doma, score 8.8e-83 716540016306 PS00467 Ribosomal protein L2 signature. 716540016307 HMMPfam hit to PF00181, Ribosomal Proteins L2, RNA binding dom, score 1.6e-47 716540016308 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 716540016309 HMMPfam hit to PF00276, Ribosomal protein L23, score 2.6e-42 716540016310 PS00430 TonB-dependent receptor proteins signature 1. 716540016311 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 716540016312 HMMPfam hit to PF00573, Ribosomal protein L4/L1 family, score 1.7e-56 716540016313 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 716540016314 HMMPfam hit to PF00297, Ribosomal protein L3, score 1.8e-103 716540016315 PS00474 Ribosomal protein L3 signature. 716540016316 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 716540016317 HMMPfam hit to PF00338, Ribosomal protein S10p/S20e, score 5.7e-62 716540016318 PS00361 Ribosomal protein S10 signature. 716540016319 elongation factor Tu; Reviewed; Region: PRK00049 716540016320 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 716540016321 G1 box; other site 716540016322 GEF interaction site [polypeptide binding]; other site 716540016323 GTP/Mg2+ binding site [chemical binding]; other site 716540016324 Switch I region; other site 716540016325 G2 box; other site 716540016326 G3 box; other site 716540016327 Switch II region; other site 716540016328 G4 box; other site 716540016329 G5 box; other site 716540016330 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 716540016331 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 716540016332 Antibiotic Binding Site [chemical binding]; other site 716540016333 HMMPfam hit to PF03143, Elongation factor Tu C-terminal domain, score 2.6e-60 716540016334 HMMPfam hit to PF03144, Elongation factor Tu domain, score 1.2e-26 716540016335 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 2.4e-95 716540016336 PS00301 GTP-binding elongation factors signature. 716540016337 PS00017 ATP/GTP-binding site motif A (P-loop). 716540016338 elongation factor G; Reviewed; Region: PRK00007 716540016339 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 716540016340 G1 box; other site 716540016341 putative GEF interaction site [polypeptide binding]; other site 716540016342 GTP/Mg2+ binding site [chemical binding]; other site 716540016343 Switch I region; other site 716540016344 G2 box; other site 716540016345 G3 box; other site 716540016346 Switch II region; other site 716540016347 G4 box; other site 716540016348 G5 box; other site 716540016349 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 716540016350 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 716540016351 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 716540016352 HMMPfam hit to PF00679, Elongation factor G C-terminus, score 1e-51 716540016353 HMMPfam hit to PF03764, Elongation factor G, domain IV, score 6.5e-72 716540016354 HMMPfam hit to PF03144, Elongation factor Tu domain, score 1.5e-20 716540016355 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 1e-109 716540016356 PS00301 GTP-binding elongation factors signature. 716540016357 PS00017 ATP/GTP-binding site motif A (P-loop). 716540016358 30S ribosomal protein S7; Validated; Region: PRK05302 716540016359 HMMPfam hit to PF00177, Ribosomal protein S7p/S5e, score 3.1e-88 716540016360 PS00052 Ribosomal protein S7 signature. 716540016361 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 716540016362 S17 interaction site [polypeptide binding]; other site 716540016363 S8 interaction site; other site 716540016364 16S rRNA interaction site [nucleotide binding]; other site 716540016365 streptomycin interaction site [chemical binding]; other site 716540016366 23S rRNA interaction site [nucleotide binding]; other site 716540016367 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 716540016368 HMMPfam hit to PF00164, Ribosomal protein S12, score 1.5e-74 716540016369 PS00055 Ribosomal protein S12 signature. 716540016370 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 716540016371 HMMPfam hit to PF04077, DsrH like protein, score 8.7e-31 716540016372 sulfur relay protein TusC; Validated; Region: PRK00211 716540016373 HMMPfam hit to PF02635, DsrE/DsrF-like family, score 2e-41 716540016374 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 716540016375 HMMPfam hit to PF02635, DsrE/DsrF-like family, score 1.2e-44 716540016376 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 716540016377 YheO-like PAS domain; Region: PAS_6; pfam08348 716540016378 HTH domain; Region: HTH_22; pfam13309 716540016379 HMMPfam hit to PF08348, YheO-like protein, score 1.9e-58 716540016380 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 716540016381 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 716540016382 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 716540016383 HMMPfam hit to PF00254, FKBP-type peptidyl-prolyl cis-trans isomeras, score 3e-45 716540016384 PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2. 716540016385 HMMPfam hit to PF01346, Domain amino terminal to FKBP-type peptidyl-, score 5.7e-45 716540016386 Signal peptide predicted for EAM_3208 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.961 between residues 25 and 26 716540016387 phi X174 lysis protein; Provisional; Region: PRK02793 716540016388 HMMPfam hit to PF04102, SlyX, score 3.6e-31 716540016389 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 716540016390 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 716540016391 HMMPfam hit to PF00254, FKBP-type peptidyl-prolyl cis-trans isomeras, score 0.00093 716540016392 PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2. 716540016393 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. 716540016394 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 716540016395 Signal peptide predicted for EAM_3211 by SignalP 2.0 HMM (Signal peptide probability 0.952) with cleavage site probability 0.952 between residues 16 and 17 716540016396 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 716540016397 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 716540016398 TrkA-N domain; Region: TrkA_N; pfam02254 716540016399 HMMPfam hit to PF02254, TrkA-N domain, score 1e-30 716540016400 12 transmembrane helices predicted for EAM_3212 by TMHMM2.0 at aa 5-24, 29-51, 56-73, 86-108, 113-135, 148-170, 180-202, 223-245, 265-287, 294-313, 328-350 and 357-376 716540016401 HMMPfam hit to PF00999, Sodium/hydrogen exchanger family, score 2.2e-74 716540016402 Signal peptide predicted for EAM_3212 by SignalP 2.0 HMM (Signal peptide probability 0.865) with cleavage site probability 0.764 between residues 20 and 21 716540016403 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 716540016404 HMMPfam hit to PF02525, Flavodoxin-like fold, score 6.1e-63 716540016405 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 716540016406 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716540016407 Walker A/P-loop; other site 716540016408 ATP binding site [chemical binding]; other site 716540016409 Q-loop/lid; other site 716540016410 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 716540016411 ABC transporter; Region: ABC_tran_2; pfam12848 716540016412 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 716540016413 HMMPfam hit to PF00005, ABC transporter, score 3.2e-45 716540016414 PS00017 ATP/GTP-binding site motif A (P-loop). 716540016415 PS00211 ABC transporters family signature. 716540016416 HMMPfam hit to PF00005, ABC transporter, score 4.6e-46 716540016417 PS00017 ATP/GTP-binding site motif A (P-loop). 716540016418 PS00211 ABC transporters family signature. 716540016419 PS00017 ATP/GTP-binding site motif A (P-loop). 716540016420 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 716540016421 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 716540016422 active site 716540016423 iron coordination sites [ion binding]; other site 716540016424 substrate binding pocket [chemical binding]; other site 716540016425 HMMPfam hit to PF02668, Taurine catabolism dioxygenase TauD, TfdA fa, score 6.5e-113 716540016426 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 716540016427 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540016428 dimer interface [polypeptide binding]; other site 716540016429 conserved gate region; other site 716540016430 putative PBP binding loops; other site 716540016431 ABC-ATPase subunit interface; other site 716540016432 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 3e-25 716540016433 6 transmembrane helices predicted for EAM_3217 by TMHMM2.0 at aa 20-42, 85-107, 119-141, 146-165, 186-208 and 236-258 716540016434 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 716540016435 Signal peptide predicted for EAM_3217 by SignalP 2.0 HMM (Signal peptide probability 0.761) with cleavage site probability 0.300 between residues 36 and 37 716540016436 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 716540016437 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 716540016438 Walker A/P-loop; other site 716540016439 ATP binding site [chemical binding]; other site 716540016440 Q-loop/lid; other site 716540016441 ABC transporter signature motif; other site 716540016442 Walker B; other site 716540016443 D-loop; other site 716540016444 H-loop/switch region; other site 716540016445 HMMPfam hit to PF00005, ABC transporter, score 6.5e-56 716540016446 PS00211 ABC transporters family signature. 716540016447 PS00017 ATP/GTP-binding site motif A (P-loop). 716540016448 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 716540016449 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 716540016450 substrate binding pocket [chemical binding]; other site 716540016451 membrane-bound complex binding site; other site 716540016452 hinge residues; other site 716540016453 HMMPfam hit to PF04069, Substrate binding domain of ABC-type glycine, score 2.7e-23 716540016454 Signal peptide predicted for EAM_3219 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.995 between residues 23 and 24 716540016455 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 716540016456 6 transmembrane helices predicted for EAM_3220 by TMHMM2.0 at aa 10-32, 39-61, 65-87, 108-130, 145-167 and 180-199 716540016457 putative hydrolase; Provisional; Region: PRK10985 716540016458 HMMPfam hit to PF00561, alpha/beta hydrolase fold, score 4.6e-08 716540016459 PS01133 Uncharacterized protein family UPF0017 signature. 716540016460 hypothetical protein; Provisional; Region: PRK04966 716540016461 HMMPfam hit to PF06794, Uncharacterised protein family (UPF0270), score 5.5e-46 716540016462 phosphoribulokinase; Provisional; Region: PRK15453 716540016463 active site 716540016464 HMMPfam hit to PF00485, Phosphoribulokinase / Uridine kinase family, score 2.3e-117 716540016465 PS00017 ATP/GTP-binding site motif A (P-loop). 716540016466 PS00567 Phosphoribulokinase signature. 716540016467 hypothetical protein; Provisional; Region: PRK10738 716540016468 HMMPfam hit to PF02566, OsmC-like protein, score 1.9e-25 716540016469 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 716540016470 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 716540016471 ligand binding site [chemical binding]; other site 716540016472 flexible hinge region; other site 716540016473 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 716540016474 putative switch regulator; other site 716540016475 non-specific DNA interactions [nucleotide binding]; other site 716540016476 DNA binding site [nucleotide binding] 716540016477 sequence specific DNA binding site [nucleotide binding]; other site 716540016478 putative cAMP binding site [chemical binding]; other site 716540016479 HMMPfam hit to PF00027, Cyclic nucleotide-binding domain, score 2.7e-27 716540016480 PS00888 Cyclic nucleotide-binding domain signature 1. 716540016481 PS00889 Cyclic nucleotide-binding domain signature 2. 716540016482 HMMPfam hit to PF00325, Bacterial regulatory proteins, crp famil, score 1.4e-15 716540016483 PS00042 Bacterial regulatory proteins, crp family signature. 716540016484 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 716540016485 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 716540016486 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 716540016487 HMMPfam hit to PF05976, Bacterial membrane protein of unknown functi, score 4.4e-09 716540016488 8 transmembrane helices predicted for EAM_3226 by TMHMM2.0 at aa 13-32, 63-82, 89-111, 131-153, 370-392, 431-453, 458-477 and 482-504 716540016489 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 716540016490 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 716540016491 inhibitor-cofactor binding pocket; inhibition site 716540016492 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716540016493 catalytic residue [active] 716540016494 HMMPfam hit to PF00155, Aminotransferase class I and II, score 7.4e-05 716540016495 HMMPfam hit to PF00202, Aminotransferase class-III, score 2.2e-173 716540016496 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 716540016497 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 716540016498 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 716540016499 glutamine binding [chemical binding]; other site 716540016500 catalytic triad [active] 716540016501 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 3.6e-81 716540016502 PS00442 Glutamine amidotransferases class-I active site. 716540016503 PS00678 Trp-Asp (WD) repeats signature. 716540016504 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 716540016505 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 716540016506 substrate binding site [chemical binding]; other site 716540016507 HMMPfam hit to PF00160, Cyclophilin type peptidyl-prolyl cis-tr, score 8.5e-69 716540016508 PS00170 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. 716540016509 Signal peptide predicted for EAM_3229 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.983 between residues 24 and 25 716540016510 putative transporter; Provisional; Region: PRK03699 716540016511 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540016512 putative substrate translocation pore; other site 716540016513 12 transmembrane helices predicted for EAM_3230 by TMHMM2.0 at aa 7-29, 49-71, 76-98, 103-125, 134-156, 161-183, 203-225, 245-267, 272-289, 299-321, 328-350 and 360-382 716540016514 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.2e-18 716540016515 Signal peptide predicted for EAM_3233 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.997 between residues 27 and 28 716540016516 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 716540016517 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 716540016518 active site 716540016519 HIGH motif; other site 716540016520 dimer interface [polypeptide binding]; other site 716540016521 KMSKS motif; other site 716540016522 HMMPfam hit to PF00579, tRNA synthetases class I (W and Y), score 3.8e-124 716540016523 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 716540016524 phosphoglycolate phosphatase; Provisional; Region: PRK13222 716540016525 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 716540016526 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716540016527 motif II; other site 716540016528 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 8.3e-35 716540016529 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 716540016530 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 716540016531 substrate binding site [chemical binding]; other site 716540016532 hexamer interface [polypeptide binding]; other site 716540016533 metal binding site [ion binding]; metal-binding site 716540016534 HMMPfam hit to PF00834, Ribulose-phosphate 3 epimerase family, score 3.1e-139 716540016535 PS01086 Ribulose-phosphate 3-epimerase family signature 2. 716540016536 PS01085 Ribulose-phosphate 3-epimerase family signature 1. 716540016537 Signal peptide predicted for EAM_3236 by SignalP 2.0 HMM (Signal peptide probability 0.712) with cleavage site probability 0.400 between residues 19 and 20 716540016538 DNA adenine methylase; Provisional; Region: PRK10904 716540016539 HMMPfam hit to PF02086, D12 class N6 adenine-specific DNA met, score 2.7e-91 716540016540 PS00092 N-6 Adenine-specific DNA methylases signature. 716540016541 hypothetical protein; Reviewed; Region: PRK11901 716540016542 cell division protein DamX; Validated; Region: PRK10905 716540016543 HMMPfam hit to PF05036, Sporulation related domain, score 2.6e-12 716540016544 1 transmembrane helix predicted for EAM_3238 by TMHMM2.0 at aa 36-58 716540016545 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 716540016546 active site 716540016547 dimer interface [polypeptide binding]; other site 716540016548 metal binding site [ion binding]; metal-binding site 716540016549 HMMPfam hit to PF01761, 3-dehydroquinate synthase, score 5.2e-180 716540016550 shikimate kinase; Reviewed; Region: aroK; PRK00131 716540016551 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 716540016552 ADP binding site [chemical binding]; other site 716540016553 magnesium binding site [ion binding]; other site 716540016554 putative shikimate binding site; other site 716540016555 HMMPfam hit to PF01202, Shikimate kinase, score 2.1e-81 716540016556 PS01128 Shikimate kinase signature. 716540016557 PS00017 ATP/GTP-binding site motif A (P-loop). 716540016558 putative outer membrane porin HofQ; Provisional; Region: hofQ; PRK13568 716540016559 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 716540016560 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 716540016561 HMMPfam hit to PF00263, Bacterial type II and III secretion system, score 5.1e-72 716540016562 PS00875 Bacterial type II secretion system protein D signature. 716540016563 HMMPfam hit to PF03958, Bacterial type II/III secretion system sho, score 4.4e-07 716540016564 HMMPfam hit to PF07660, Secretin and TonB N terminus short domain, score 6.2e-09 716540016565 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 716540016566 Signal peptide predicted for EAM_3242 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.805 between residues 19 and 20 716540016567 Signal peptide predicted for EAM_3243 by SignalP 2.0 HMM (Signal peptide probability 0.646) with cleavage site probability 0.546 between residues 43 and 44 716540016568 1 transmembrane helix predicted for EAM_3243 by TMHMM2.0 at aa 15-37 716540016569 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 716540016570 HMMPfam hit to PF05137, Fimbrial assembly protein (PilN), score 7.8e-06 716540016571 1 transmembrane helix predicted for EAM_3244 by TMHMM2.0 at aa 20-42 716540016572 Signal peptide predicted for EAM_3244 by SignalP 2.0 HMM (Signal peptide probability 0.934) with cleavage site probability 0.931 between residues 39 and 40 716540016573 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 716540016574 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 716540016575 Transglycosylase; Region: Transgly; pfam00912 716540016576 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 716540016577 Signal peptide predicted for EAM_3246 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.322 between residues 19 and 20 716540016578 1 transmembrane helix predicted for EAM_3246 by TMHMM2.0 at aa 7-26 716540016579 HMMPfam hit to PF00912, Transglycosylase, score 2.4e-93 716540016580 HMMPfam hit to PF00905, Penicillin binding protein transpeptid, score 8e-22 716540016581 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 716540016582 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 716540016583 ADP-ribose binding site [chemical binding]; other site 716540016584 dimer interface [polypeptide binding]; other site 716540016585 active site 716540016586 nudix motif; other site 716540016587 metal binding site [ion binding]; metal-binding site 716540016588 HMMPfam hit to PF00293, NUDIX domain, score 8.7e-13 716540016589 PS00893 mutT domain signature. 716540016590 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 716540016591 HMMPfam hit to PF07095, Intracellular growth attenuator protein IgaA, score 0 716540016592 Signal peptide predicted for EAM_3248 by SignalP 2.0 HMM (Signal peptide probability 0.986) with cleavage site probability 0.623 between residues 33 and 34 716540016593 5 transmembrane helices predicted for EAM_3248 by TMHMM2.0 at aa 4-26, 208-227, 231-248, 342-364 and 655-677 716540016594 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540016595 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 716540016596 RNA binding surface [nucleotide binding]; other site 716540016597 HMMPfam hit to PF01479, S4 domain, score 2.1e-11 716540016598 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 716540016599 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 716540016600 dimerization interface [polypeptide binding]; other site 716540016601 domain crossover interface; other site 716540016602 redox-dependent activation switch; other site 716540016603 HMMPfam hit to PF01430, Hsp33 protein, score 7e-131 716540016604 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 716540016605 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 716540016606 active site 716540016607 substrate-binding site [chemical binding]; other site 716540016608 metal-binding site [ion binding] 716540016609 ATP binding site [chemical binding]; other site 716540016610 HMMPfam hit to PF01293, Phosphoenolpyruvate carboxykinase, score 0 716540016611 PS00017 ATP/GTP-binding site motif A (P-loop). 716540016612 PS00532 Phosphoenolpyruvate carboxykinase (ATP) signature. 716540016613 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 716540016614 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 716540016615 dimerization interface [polypeptide binding]; other site 716540016616 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 716540016617 dimer interface [polypeptide binding]; other site 716540016618 phosphorylation site [posttranslational modification] 716540016619 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716540016620 ATP binding site [chemical binding]; other site 716540016621 Mg2+ binding site [ion binding]; other site 716540016622 G-X-G motif; other site 716540016623 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 1.7e-34 716540016624 PS00017 ATP/GTP-binding site motif A (P-loop). 716540016625 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 6.5e-14 716540016626 HMMPfam hit to PF00672, HAMP domain, score 5.2e-12 716540016627 2 transmembrane helices predicted for EAM_3252 by TMHMM2.0 at aa 15-37 and 160-179 716540016628 Signal peptide predicted for EAM_3252 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.321 between residues 34 and 35 716540016629 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 716540016630 osmolarity response regulator; Provisional; Region: ompR; PRK09468 716540016631 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716540016632 active site 716540016633 phosphorylation site [posttranslational modification] 716540016634 intermolecular recognition site; other site 716540016635 dimerization interface [polypeptide binding]; other site 716540016636 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 716540016637 DNA binding site [nucleotide binding] 716540016638 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 4.2e-20 716540016639 HMMPfam hit to PF00072, Response regulator receiver domain, score 4.8e-41 716540016640 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 716540016641 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 716540016642 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 716540016643 HMMPfam hit to PF03449, Prokaryotic transcription elongation fact, score 7.1e-42 716540016644 PS00829 Prokaryotic transcription elongation factors signature 1. 716540016645 HMMPfam hit to PF01272, Prokaryotic transcription elongation fact, score 8.5e-39 716540016646 PS00830 Prokaryotic transcription elongation factors signature 2. 716540016647 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 716540016648 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 716540016649 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 716540016650 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 716540016651 RNA binding site [nucleotide binding]; other site 716540016652 HMMPfam hit to PF00575, S1 RNA binding domain, score 5.8e-27 716540016653 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 716540016654 sucrose phosphorylase; Provisional; Region: PRK13840 716540016655 active site 716540016656 homodimer interface [polypeptide binding]; other site 716540016657 catalytic site [active] 716540016658 HMMPfam hit to PF00128, Alpha amylase, catalytic domain, score 1.8e-07 716540016659 carboxylesterase BioH; Provisional; Region: PRK10349 716540016660 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 716540016661 HMMPfam hit to PF00561, alpha/beta hydrolase fold, score 1.2e-24 716540016662 DNA utilization protein GntX; Provisional; Region: PRK11595 716540016663 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 716540016664 active site 716540016665 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 716540016666 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 716540016667 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 716540016668 HMMPfam hit to PF01521, Iron-sulphur cluster biosynthesis, score 1.9e-30 716540016669 HMMPfam hit to PF01106, NifU-like domain, score 1.1e-06 716540016670 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 716540016671 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 716540016672 HMMPfam hit to PF02446, 4-alpha-glucanotransferase, score 4.6e-197 716540016673 Signal peptide predicted for EAM_3260 by SignalP 2.0 HMM (Signal peptide probability 0.973) with cleavage site probability 0.489 between residues 22 and 23 716540016674 maltodextrin phosphorylase; Provisional; Region: PRK14985 716540016675 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 716540016676 active site pocket [active] 716540016677 HMMPfam hit to PF00343, Carbohydrate phosphorylase, score 0 716540016678 PS00102 Phosphorylase pyridoxal-phosphate attachment site. 716540016679 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 716540016680 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 716540016681 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 716540016682 HMMPfam hit to PF00455, Bacterial regulatory proteins, deoR family, score 6.1e-72 716540016683 HMMPfam hit to PF08220, DeoR-like helix-turn-helix domain, score 7e-28 716540016684 HMMPfam hit to PF08279, HTH domain, score 0.00041 716540016685 PS00894 Bacterial regulatory proteins, deoR family signature. 716540016686 intramembrane serine protease GlpG; Provisional; Region: PRK10907 716540016687 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 716540016688 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 716540016689 HMMPfam hit to PF01694, Rhomboid family, score 7.8e-30 716540016690 6 transmembrane helices predicted for EAM_3263 by TMHMM2.0 at aa 92-114, 140-162, 167-186, 190-212, 221-243 and 248-265 716540016691 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 716540016692 active site residue [active] 716540016693 HMMPfam hit to PF00581, Rhodanese-like domain, score 2.2e-09 716540016694 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 716540016695 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 1.5e-69 716540016696 PS00977 FAD-dependent glycerol-3-phosphate dehydrogenase signature 1. 716540016697 PS00978 FAD-dependent glycerol-3-phosphate dehydrogenase signature 2. 716540016698 glycogen phosphorylase; Provisional; Region: PRK14986 716540016699 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 716540016700 homodimer interface [polypeptide binding]; other site 716540016701 active site pocket [active] 716540016702 HMMPfam hit to PF00343, Carbohydrate phosphorylase, score 0 716540016703 PS00102 Phosphorylase pyridoxal-phosphate attachment site. 716540016704 glycogen synthase; Provisional; Region: glgA; PRK00654 716540016705 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 716540016706 ADP-binding pocket [chemical binding]; other site 716540016707 homodimer interface [polypeptide binding]; other site 716540016708 HMMPfam hit to PF00534, Glycosyl transferases group, score 7.4e-11 716540016709 HMMPfam hit to PF08323, Starch synthase catalytic domain, score 7.6e-112 716540016710 PS00589 PTS HPR component serine phosphorylation site signature. 716540016711 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 716540016712 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 716540016713 ligand binding site; other site 716540016714 oligomer interface; other site 716540016715 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 716540016716 dimer interface [polypeptide binding]; other site 716540016717 N-terminal domain interface [polypeptide binding]; other site 716540016718 sulfate 1 binding site; other site 716540016719 HMMPfam hit to PF00483, Nucleotidyl transferase, score 2.7e-87 716540016720 PS00809 ADP-glucose pyrophosphorylase signature 2. 716540016721 PS00808 ADP-glucose pyrophosphorylase signature 1. 716540016722 glycogen debranching enzyme; Provisional; Region: PRK03705 716540016723 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 716540016724 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 716540016725 active site 716540016726 catalytic site [active] 716540016727 HMMPfam hit to PF00128, Alpha amylase, catalytic domain, score 3.5e-10 716540016728 HMMPfam hit to PF02922, Isoamylase N-terminal domain, score 7e-26 716540016729 glycogen branching enzyme; Provisional; Region: PRK05402 716540016730 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 716540016731 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 716540016732 active site 716540016733 catalytic site [active] 716540016734 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 716540016735 HMMPfam hit to PF00128, Alpha amylase, catalytic domain, score 4.4e-08 716540016736 HMMPfam hit to PF02922, Isoamylase N-terminal domain, score 3.9e-35 716540016737 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 716540016738 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 716540016739 HMMPfam hit to PF02774, Semialdehyde dehydrogenase, dimerisat, score 1.7e-78 716540016740 PS01103 Aspartate-semialdehyde dehydrogenase signature. 716540016741 HMMPfam hit to PF01118, Semialdehyde dehydrogenase, NAD bindi, score 6.2e-36 716540016742 low affinity gluconate transporter; Provisional; Region: PRK10472 716540016743 gluconate transporter; Region: gntP; TIGR00791 716540016744 HMMPfam hit to PF02447, GntP family permease, score 7.4e-234 716540016745 12 transmembrane helices predicted for EAM_3274 by TMHMM2.0 at aa 5-22, 26-45, 57-79, 104-126, 139-161, 176-198, 225-247, 262-283, 295-317, 332-354, 386-408 and 423-445 716540016746 HMMPfam hit to PF03600, Citrate transporter, score 0.00018 716540016747 Signal peptide predicted for EAM_3274 by SignalP 2.0 HMM (Signal peptide probability 0.981) with cleavage site probability 0.209 between residues 33 and 34 716540016748 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 716540016749 ATP-binding site [chemical binding]; other site 716540016750 Gluconate-6-phosphate binding site [chemical binding]; other site 716540016751 Shikimate kinase; Region: SKI; pfam01202 716540016752 HMMPfam hit to PF01202, Shikimate kinase, score 3.8e-07 716540016753 Signal peptide predicted for EAM_3275 by SignalP 2.0 HMM (Signal peptide probability 0.918) with cleavage site probability 0.618 between residues 27 and 28 716540016754 PS00017 ATP/GTP-binding site motif A (P-loop). 716540016755 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 716540016756 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 716540016757 DNA binding site [nucleotide binding] 716540016758 domain linker motif; other site 716540016759 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 716540016760 putative ligand binding site [chemical binding]; other site 716540016761 putative dimerization interface [polypeptide binding]; other site 716540016762 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 1.2e-16 716540016763 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 1.8e-05 716540016764 Pirin-related protein [General function prediction only]; Region: COG1741 716540016765 Pirin; Region: Pirin; pfam02678 716540016766 HMMPfam hit to PF07883, Cupin domain, score 1.2e-06 716540016767 HMMPfam hit to PF02678, Pirin, score 1.3e-65 716540016768 putative acetyltransferase YhhY; Provisional; Region: PRK10140 716540016769 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716540016770 Coenzyme A binding pocket [chemical binding]; other site 716540016771 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 5.1e-19 716540016772 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 716540016773 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 716540016774 HMMPfam hit to PF01019, Gamma-glutamyltranspeptidase, score 6.9e-261 716540016775 PS00462 Gamma-glutamyltranspeptidase signature. 716540016776 Signal peptide predicted for EAM_3279 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.816 between residues 26 and 27 716540016777 Signal peptide predicted for EAM_3280 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.479 between residues 19 and 20 716540016778 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 716540016779 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 716540016780 putative active site [active] 716540016781 catalytic site [active] 716540016782 putative metal binding site [ion binding]; other site 716540016783 HMMPfam hit to PF03009, Glycerophosphoryl diester phosphodiesterase, score 9.9e-64 716540016784 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 716540016785 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 716540016786 Walker A/P-loop; other site 716540016787 ATP binding site [chemical binding]; other site 716540016788 Q-loop/lid; other site 716540016789 ABC transporter signature motif; other site 716540016790 Walker B; other site 716540016791 D-loop; other site 716540016792 H-loop/switch region; other site 716540016793 TOBE domain; Region: TOBE_2; pfam08402 716540016794 HMMPfam hit to PF08402, TOBE domain, score 6e-14 716540016795 HMMPfam hit to PF00005, ABC transporter, score 1e-60 716540016796 PS00211 ABC transporters family signature. 716540016797 PS00017 ATP/GTP-binding site motif A (P-loop). 716540016798 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 716540016799 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540016800 dimer interface [polypeptide binding]; other site 716540016801 conserved gate region; other site 716540016802 putative PBP binding loops; other site 716540016803 ABC-ATPase subunit interface; other site 716540016804 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 4.3e-24 716540016805 6 transmembrane helices predicted for EAM_3283 by TMHMM2.0 at aa 13-35, 82-104, 111-130, 145-162, 199-221 and 250-267 716540016806 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 716540016807 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 716540016808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540016809 dimer interface [polypeptide binding]; other site 716540016810 conserved gate region; other site 716540016811 putative PBP binding loops; other site 716540016812 ABC-ATPase subunit interface; other site 716540016813 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 8.9e-15 716540016814 6 transmembrane helices predicted for EAM_3284 by TMHMM2.0 at aa 12-34, 79-101, 108-130, 157-179, 203-225 and 266-288 716540016815 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 716540016816 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 716540016817 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 716540016818 HMMPfam hit to PF01547, Bacterial extracellular solute-binding prot, score 5.7e-29 716540016819 PS01037 Bacterial extracellular solute-binding proteins, family 1 signature. 716540016820 Signal peptide predicted for EAM_3285 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 25 and 26 716540016821 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 716540016822 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 716540016823 Walker A/P-loop; other site 716540016824 ATP binding site [chemical binding]; other site 716540016825 Q-loop/lid; other site 716540016826 ABC transporter signature motif; other site 716540016827 Walker B; other site 716540016828 D-loop; other site 716540016829 H-loop/switch region; other site 716540016830 HMMPfam hit to PF00005, ABC transporter, score 4.4e-57 716540016831 PS00211 ABC transporters family signature. 716540016832 PS00017 ATP/GTP-binding site motif A (P-loop). 716540016833 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 716540016834 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 716540016835 Walker A/P-loop; other site 716540016836 ATP binding site [chemical binding]; other site 716540016837 Q-loop/lid; other site 716540016838 ABC transporter signature motif; other site 716540016839 Walker B; other site 716540016840 D-loop; other site 716540016841 H-loop/switch region; other site 716540016842 HMMPfam hit to PF00005, ABC transporter, score 3.4e-61 716540016843 PS00211 ABC transporters family signature. 716540016844 PS00017 ATP/GTP-binding site motif A (P-loop). 716540016845 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 716540016846 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 716540016847 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 716540016848 TM-ABC transporter signature motif; other site 716540016849 10 transmembrane helices predicted for EAM_3288 by TMHMM2.0 at aa 10-30, 43-65, 85-107, 120-142, 162-184, 193-210, 261-283, 315-337, 352-374 and 387-404 716540016850 HMMPfam hit to PF02653, Branched-chain amino acid transport syst, score 2.1e-71 716540016851 Signal peptide predicted for EAM_3288 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.721 between residues 29 and 30 716540016852 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 716540016853 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 716540016854 TM-ABC transporter signature motif; other site 716540016855 8 transmembrane helices predicted for EAM_3289 by TMHMM2.0 at aa 15-37, 44-66, 70-92, 105-127, 153-175, 207-229, 244-266 and 282-301 716540016856 HMMPfam hit to PF02653, Branched-chain amino acid transport syst, score 1.8e-61 716540016857 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 716540016858 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 716540016859 dimerization interface [polypeptide binding]; other site 716540016860 ligand binding site [chemical binding]; other site 716540016861 HMMPfam hit to PF01094, Receptor family ligand binding region, score 2.8e-67 716540016862 Signal peptide predicted for EAM_3290 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.995 between residues 24 and 25 716540016863 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 716540016864 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 716540016865 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 716540016866 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 716540016867 DNA binding residues [nucleotide binding] 716540016868 HMMPfam hit to PF04545, Sigma-70, region, score 2.4e-17 716540016869 PS00716 Sigma-70 factors family signature 2. 716540016870 HMMPfam hit to PF04542, Sigma-70 region, score 6.8e-22 716540016871 PS00715 Sigma-70 factors family signature 1. 716540016872 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 716540016873 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 716540016874 HMMPfam hit to PF02687, Predicted permease, score 1.3e-24 716540016875 5 transmembrane helices predicted for EAM_3293 by TMHMM2.0 at aa 41-63, 187-209, 240-262, 269-288 and 292-311 716540016876 cell division protein FtsE; Provisional; Region: PRK10908 716540016877 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716540016878 Walker A/P-loop; other site 716540016879 ATP binding site [chemical binding]; other site 716540016880 Q-loop/lid; other site 716540016881 ABC transporter signature motif; other site 716540016882 Walker B; other site 716540016883 D-loop; other site 716540016884 H-loop/switch region; other site 716540016885 HMMPfam hit to PF00005, ABC transporter, score 1.5e-69 716540016886 PS00211 ABC transporters family signature. 716540016887 PS00017 ATP/GTP-binding site motif A (P-loop). 716540016888 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 716540016889 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 716540016890 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 716540016891 P loop; other site 716540016892 GTP binding site [chemical binding]; other site 716540016893 HMMPfam hit to PF00448, SRP54-type protein, GTPase domain, score 3.4e-122 716540016894 PS00300 SRP54-type proteins GTP-binding domain signature. 716540016895 PS00017 ATP/GTP-binding site motif A (P-loop). 716540016896 HMMPfam hit to PF02881, SRP54-type protein, helical bundle domain, score 4.6e-17 716540016897 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 716540016898 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716540016899 S-adenosylmethionine binding site [chemical binding]; other site 716540016900 HMMPfam hit to PF03602, Conserved hypothetical protein, score 6.2e-84 716540016901 PS00092 N-6 Adenine-specific DNA methylases signature. 716540016902 hypothetical protein; Provisional; Region: PRK10910 716540016903 HMMPfam hit to PF06611, Protein of unknown function (DUF1145), score 4.6e-29 716540016904 3 transmembrane helices predicted for EAM_3297 by TMHMM2.0 at aa 5-22, 29-51 and 64-81 716540016905 Predicted membrane protein [Function unknown]; Region: COG3714 716540016906 HMMPfam hit to PF07947, YhhN-like protein, score 4.8e-44 716540016907 6 transmembrane helices predicted for EAM_3298 by TMHMM2.0 at aa 53-71, 76-98, 102-121, 128-145, 160-177 and 184-203 716540016908 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 716540016909 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 716540016910 metal-binding site [ion binding] 716540016911 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 716540016912 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 716540016913 HMMPfam hit to PF00403, Heavy-metal-associated domain, score 6.6e-07 716540016914 PS01047 Heavy-metal-associated domain. 716540016915 5 transmembrane helices predicted for EAM_3299 by TMHMM2.0 at aa 147-169, 205-227, 367-389, 404-426 and 706-728 716540016916 HMMPfam hit to PF00122, E1-E2 ATPase, score 1.2e-81 716540016917 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 7.8e-34 716540016918 PS00154 E1-E2 ATPases phosphorylation site. 716540016919 PS01229 Hypothetical cof family signature 2. 716540016920 PS00141 Eukaryotic and viral aspartyl proteases active site. 716540016921 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 716540016922 CPxP motif; other site 716540016923 HMMPfam hit to PF01206, SirA-like protein, score 9e-37 716540016924 PS01148 Uncharacterized protein family UPF0033 signature. 716540016925 hypothetical protein; Provisional; Region: PRK11212 716540016926 6 transmembrane helices predicted for EAM_3301 by TMHMM2.0 at aa 13-32, 42-64, 71-91, 106-125, 138-160 and 180-202 716540016927 HMMPfam hit to PF02592, Uncharacterized ACR, YhhQ family COG1738, score 2.2e-67 716540016928 hypothetical protein; Provisional; Region: PRK11615 716540016929 Signal peptide predicted for EAM_3302 by SignalP 2.0 HMM (Signal peptide probability 0.885) with cleavage site probability 0.421 between residues 19 and 20 716540016930 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540016931 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 716540016932 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 716540016933 Metal-binding active site; metal-binding site 716540016934 HMMPfam hit to PF01261, Xylose isomerase-like TIM barrel, score 1.8e-43 716540016935 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 716540016936 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 716540016937 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 716540016938 HMMPfam hit to PF02894, Oxidoreductase family, C-terminal alph, score 1.2e-07 716540016939 HMMPfam hit to PF01408, Oxidoreductase family, NAD-binding Ros, score 1e-31 716540016940 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 716540016941 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 716540016942 PYR/PP interface [polypeptide binding]; other site 716540016943 dimer interface [polypeptide binding]; other site 716540016944 TPP binding site [chemical binding]; other site 716540016945 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 716540016946 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 716540016947 TPP-binding site; other site 716540016948 HMMPfam hit to PF02775, Thiamine pyrophosphate enzyme, C-termina, score 1.6e-45 716540016949 PS00187 Thiamine pyrophosphate enzymes signature. 716540016950 HMMPfam hit to PF00205, Thiamine pyrophosphate enzyme, central d, score 1.5e-32 716540016951 HMMPfam hit to PF02776, Thiamine pyrophosphate enzyme, N-termina, score 1.7e-09 716540016952 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 716540016953 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 716540016954 substrate binding site [chemical binding]; other site 716540016955 ATP binding site [chemical binding]; other site 716540016956 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 716540016957 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 716540016958 HMMPfam hit to PF00294, pfkB family carbohydrate kinase, score 3.9e-42 716540016959 PS00584 pfkB family of carbohydrate kinases signature 2. 716540016960 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 716540016961 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 716540016962 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 716540016963 putative active site [active] 716540016964 HMMPfam hit to PF01418, Helix-turn-helix domain, rpiR family, score 6e-06 716540016965 HMMPfam hit to PF01380, SIS domain, score 1.3e-34 716540016966 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 716540016967 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 716540016968 HMMPfam hit to PF06845, Myo-inositol catabolism protein IolB, score 1.7e-160 716540016969 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 716540016970 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 716540016971 tetrameric interface [polypeptide binding]; other site 716540016972 NAD binding site [chemical binding]; other site 716540016973 catalytic residues [active] 716540016974 HMMPfam hit to PF00171, Aldehyde dehydrogenase family, score 6.8e-157 716540016975 PS00017 ATP/GTP-binding site motif A (P-loop). 716540016976 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 716540016977 Domain of unknown function DUF20; Region: UPF0118; pfam01594 716540016978 8 transmembrane helices predicted for EAM_3310 by TMHMM2.0 at aa 12-29, 33-55, 62-84, 146-168, 198-220, 224-246, 253-275 and 295-317 716540016979 HMMPfam hit to PF01594, Domain of unknown function DUF20, score 1.9e-73 716540016980 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 716540016981 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 716540016982 Signal peptide predicted for EAM_3311 by SignalP 2.0 HMM (Signal peptide probability 0.914) with cleavage site probability 0.606 between residues 36 and 37 716540016983 2 transmembrane helices predicted for EAM_3311 by TMHMM2.0 at aa 12-31 and 238-260 716540016984 HMMPfam hit to PF00563, EAL domain, score 1.3e-85 716540016985 proline/glycine betaine transporter; Provisional; Region: PRK10642 716540016986 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540016987 putative substrate translocation pore; other site 716540016988 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 716540016989 HMMPfam hit to PF00083, Sugar (and other) transporter, score 2.2e-84 716540016990 12 transmembrane helices predicted for EAM_3312 by TMHMM2.0 at aa 31-53, 68-90, 99-121, 125-147, 168-190, 200-222, 261-283, 298-320, 327-349, 354-376, 389-411 and 421-438 716540016991 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.6e-24 716540016992 PS00216 Sugar transport proteins signature 1. 716540016993 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 716540016994 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 716540016995 putative NAD(P) binding site [chemical binding]; other site 716540016996 putative substrate binding site [chemical binding]; other site 716540016997 catalytic Zn binding site [ion binding]; other site 716540016998 structural Zn binding site [ion binding]; other site 716540016999 dimer interface [polypeptide binding]; other site 716540017000 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like domain, score 1.4e-32 716540017001 PS00059 Zinc-containing alcohol dehydrogenases signature. 716540017002 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 3e-31 716540017003 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 716540017004 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 716540017005 DNA binding residues [nucleotide binding] 716540017006 dimerization interface [polypeptide binding]; other site 716540017007 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR family, score 0.0011 716540017008 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 716540017009 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 716540017010 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 716540017011 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 3.3e-94 716540017012 HMMPfam hit to PF00890, FAD binding domain, score 0.00056 716540017013 1 transmembrane helix predicted for EAM_3317 by TMHMM2.0 at aa 13-35 716540017014 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 716540017015 homotrimer interaction site [polypeptide binding]; other site 716540017016 putative active site [active] 716540017017 HMMPfam hit to PF01042, Endoribonuclease L-PSP, score 1.7e-17 716540017018 ornithine cyclodeaminase; Validated; Region: PRK06199 716540017019 Ornithine cyclodeaminase/mu-crystallin family; Region: OCD_Mu_crystall; pfam02423 716540017020 HMMPfam hit to PF02423, Ornithine cyclodeaminase/mu-crystalli, score 2.4e-83 716540017021 PS00017 ATP/GTP-binding site motif A (P-loop). 716540017022 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 716540017023 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716540017024 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 0.00019 716540017025 Signal peptide predicted for EAM_3321 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.542 between residues 24 and 25 716540017026 HMMPfam hit to PF00324, Amino acid permease, score 1e-07 716540017027 11 transmembrane helices predicted for EAM_3321 by TMHMM2.0 at aa 20-42, 77-99, 103-125, 132-154, 169-190, 211-233, 259-281, 320-342, 346-368, 381-403 and 413-432 716540017028 Predicted flavoproteins [General function prediction only]; Region: COG2081 716540017029 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 716540017030 HMMPfam hit to PF03486, HI0933-like protein, score 7.3e-231 716540017031 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 7.7e-07 716540017032 HMMPfam hit to PF00890, FAD binding domain, score 0.0012 716540017033 HMMPfam hit to PF01134, Glucose inhibited division protein A, score 0.0026 716540017034 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidored, score 1.8e-05 716540017035 Signal peptide predicted for EAM_3322 by SignalP 2.0 HMM (Signal peptide probability 0.934) with cleavage site probability 0.927 between residues 22 and 23 716540017036 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 716540017037 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 716540017038 10 transmembrane helices predicted for EAM_3323 by TMHMM2.0 at aa 10-32, 52-74, 94-116, 123-145, 155-177, 207-224, 234-256, 375-397, 430-452 and 473-495 716540017039 HMMPfam hit to PF01384, Phosphate transporter family, score 5e-111 716540017040 universal stress protein UspB; Provisional; Region: PRK04960 716540017041 2 transmembrane helices predicted for EAM_3324 by TMHMM2.0 at aa 4-26 and 89-111 716540017042 PS00079 Multicopper oxidases signature 1. 716540017043 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 716540017044 Ligand Binding Site [chemical binding]; other site 716540017045 HMMPfam hit to PF00582, Universal stress protein family, score 2.5e-15 716540017046 putative methyltransferase; Provisional; Region: PRK10742 716540017047 HMMPfam hit to PF04445, Protein of unknown function (DUF548), score 2.5e-163 716540017048 oligopeptidase A; Provisional; Region: PRK10911 716540017049 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 716540017050 active site 716540017051 Zn binding site [ion binding]; other site 716540017052 HMMPfam hit to PF01432, Peptidase family M3, score 2.5e-233 716540017053 PS00037 Myb DNA-binding domain repeat signature 1. 716540017054 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 716540017055 CAAX protease self-immunity; Region: Abi; pfam02517 716540017056 Signal peptide predicted for EAM_3328 by SignalP 2.0 HMM (Signal peptide probability 0.981) with cleavage site probability 0.403 between residues 21 and 22 716540017057 8 transmembrane helices predicted for EAM_3328 by TMHMM2.0 at aa 9-31, 36-55, 62-84, 104-126, 138-160, 170-189, 210-232 and 247-269 716540017058 HMMPfam hit to PF02517, CAAX amino terminal protease family, score 7.1e-17 716540017059 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 716540017060 HMMPfam hit to PF04378, Protein of unknown function (DUF519), score 2.9e-160 716540017061 PS00092 N-6 Adenine-specific DNA methylases signature. 716540017062 PS00092 N-6 Adenine-specific DNA methylases signature. 716540017063 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 716540017064 HMMPfam hit to PF00753, Metallo-beta-lactamase superfamily, score 1.7e-08 716540017065 glutathione reductase; Validated; Region: PRK06116 716540017066 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 716540017067 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 716540017068 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 716540017069 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidored, score 2e-66 716540017070 PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 716540017071 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidored, score 4.3e-27 716540017072 HMMPfam hit to PF02852, Pyridine nucleotide-disulphide oxidored, score 4.9e-54 716540017073 H+ Antiporter protein; Region: 2A0121; TIGR00900 716540017074 3 transmembrane helices predicted for EAM_3335 by TMHMM2.0 at aa 70-92, 120-142 and 155-174 716540017075 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 716540017076 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 716540017077 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 716540017078 HMMPfam hit to PF00561, alpha/beta hydrolase fold, score 6.6e-37 716540017079 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 716540017080 HMMPfam hit to PF01292, Cytochrome b561 family, score 4.8e-46 716540017081 4 transmembrane helices predicted for EAM_3338 by TMHMM2.0 at aa 5-27, 42-64, 84-106 and 142-164 716540017082 Signal peptide predicted for EAM_3338 by SignalP 2.0 HMM (Signal peptide probability 0.655) with cleavage site probability 0.641 between residues 25 and 26 716540017083 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 716540017084 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 716540017085 FMN-binding pocket [chemical binding]; other site 716540017086 flavin binding motif; other site 716540017087 phosphate binding motif [ion binding]; other site 716540017088 beta-alpha-beta structure motif; other site 716540017089 NAD binding pocket [chemical binding]; other site 716540017090 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 716540017091 catalytic loop [active] 716540017092 iron binding site [ion binding]; other site 716540017093 HMMPfam hit to PF00111, 2Fe-2S iron-sulfur cluster binding doma, score 9.9e-14 716540017094 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 716540017095 HMMPfam hit to PF00175, Oxidoreductase NAD-binding domain, score 9.5e-05 716540017096 HMMPfam hit to PF00970, Oxidoreductase FAD-binding domain, score 0.00043 716540017097 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 716540017098 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 716540017099 [2Fe-2S] cluster binding site [ion binding]; other site 716540017100 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 716540017101 hydrophobic ligand binding site; other site 716540017102 HMMPfam hit to PF00355, Rieske [2Fe-2S] domain, score 3.8e-19 716540017103 PS00213 Lipocalin signature. 716540017104 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716540017105 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716540017106 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 716540017107 dimerization interface [polypeptide binding]; other site 716540017108 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.8e-14 716540017109 HMMPfam hit to PF03466, LysR substrate binding domain, score 2.5e-35 716540017110 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 716540017111 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 716540017112 Signal peptide predicted for EAM_3342 by SignalP 2.0 HMM (Signal peptide probability 0.805) with cleavage site probability 0.717 between residues 19 and 20 716540017113 hypothetical protein; Provisional; Region: PRK05208 716540017114 3 transmembrane helices predicted for EAM_3343 by TMHMM2.0 at aa 10-32, 53-75 and 136-155 716540017115 HMMPfam hit to PF03350, Uncharacterized protein family, UPF0114, score 4.4e-58 716540017116 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 716540017117 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 716540017118 HMMPfam hit to PF00023, Ankyrin repeat, score 0.00061 716540017119 HMMPfam hit to PF00023, Ankyrin repeat, score 6.3 716540017120 HMMPfam hit to PF00023, Ankyrin repeat, score 3.4 716540017121 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540017122 Signal peptide predicted for EAM_3344 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.941 between residues 19 and 20 716540017123 PS00120 Lipases, serine active site. 716540017124 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 716540017125 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716540017126 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 1.3e-10 716540017127 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 8e-05 716540017128 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716540017129 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 716540017130 dimerization interface [polypeptide binding]; other site 716540017131 HMMPfam hit to PF03466, LysR substrate binding domain, score 5.7e-21 716540017132 PS00464 Ribosomal protein L22 signature. 716540017133 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 716540017134 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 716540017135 FAD binding pocket [chemical binding]; other site 716540017136 FAD binding motif [chemical binding]; other site 716540017137 phosphate binding motif [ion binding]; other site 716540017138 NAD binding pocket [chemical binding]; other site 716540017139 HMMPfam hit to PF04954, Siderophore-interacting protein, score 2.5e-28 716540017140 HMMPfam hit to PF08021, Siderophore-interacting FAD-binding dom, score 1.5e-40 716540017141 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 716540017142 Protein of unknown function, DUF482; Region: DUF482; pfam04339 716540017143 HMMPfam hit to PF04339, Protein of unknown function, DUF482, score 2.5e-185 716540017144 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 716540017145 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 716540017146 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716540017147 Walker A/P-loop; other site 716540017148 ATP binding site [chemical binding]; other site 716540017149 Q-loop/lid; other site 716540017150 ABC transporter signature motif; other site 716540017151 Walker B; other site 716540017152 D-loop; other site 716540017153 H-loop/switch region; other site 716540017154 HMMPfam hit to PF00005, ABC transporter, score 1.5e-55 716540017155 PS00211 ABC transporters family signature. 716540017156 PS00017 ATP/GTP-binding site motif A (P-loop). 716540017157 PS00044 Bacterial regulatory proteins, lysR family signature. 716540017158 6 transmembrane helices predicted for EAM_3352 by TMHMM2.0 at aa 36-58, 84-106, 157-179, 183-205, 271-293 and 303-325 716540017159 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 716540017160 dimer interface [polypeptide binding]; other site 716540017161 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 716540017162 putative CheW interface [polypeptide binding]; other site 716540017163 Signal peptide predicted for EAM_3353 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.711 between residues 27 and 28 716540017164 1 transmembrane helix predicted for EAM_3353 by TMHMM2.0 at aa 7-29 716540017165 PS00538 Bacterial chemotaxis sensory transducers signature. 716540017166 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 3.2e-92 716540017167 HMMPfam hit to PF08450, SMP-30/Gluconolaconase/LRE-like region, score 1.3e-18 716540017168 HMMPfam hit to PF03758, Senescence marker protein-30 (SMP-30), N-ter, score 2.8e-09 716540017169 Signal peptide predicted for EAM_3354 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.998 between residues 29 and 30 716540017170 Signal peptide predicted for EAM_3355 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.633 between residues 23 and 24 716540017171 sensor protein KdpD; Provisional; Region: PRK10490 716540017172 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 716540017173 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 716540017174 Ligand Binding Site [chemical binding]; other site 716540017175 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 716540017176 GAF domain; Region: GAF_3; pfam13492 716540017177 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 716540017178 dimer interface [polypeptide binding]; other site 716540017179 phosphorylation site [posttranslational modification] 716540017180 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716540017181 ATP binding site [chemical binding]; other site 716540017182 Mg2+ binding site [ion binding]; other site 716540017183 G-X-G motif; other site 716540017184 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 8.6e-38 716540017185 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 1.4e-13 716540017186 3 transmembrane helices predicted for EAM_3356 by TMHMM2.0 at aa 417-439, 446-468 and 473-495 716540017187 HMMPfam hit to PF00582, Universal stress protein family, score 5.7e-09 716540017188 HMMPfam hit to PF02702, Osmosensitive K+ channel His kinase sensor, score 1.3e-145 716540017189 PS00017 ATP/GTP-binding site motif A (P-loop). 716540017190 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 716540017191 HMMPfam hit to PF02669, K+-transporting ATPase, c chain, score 6.6e-97 716540017192 Signal peptide predicted for EAM_3357 by SignalP 2.0 HMM (Signal peptide probability 0.987) with cleavage site probability 0.435 between residues 30 and 31 716540017193 1 transmembrane helix predicted for EAM_3357 by TMHMM2.0 at aa 7-29 716540017194 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 716540017195 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 716540017196 7 transmembrane helices predicted for EAM_3358 by TMHMM2.0 at aa 33-55, 60-82, 220-242, 252-274, 575-597, 612-634 and 654-676 716540017197 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 5.1e-34 716540017198 PS00154 E1-E2 ATPases phosphorylation site. 716540017199 HMMPfam hit to PF00122, E1-E2 ATPase, score 2.9e-58 716540017200 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 716540017201 HMMPfam hit to PF03814, Potassium-transporting ATPase A subunit, score 0 716540017202 12 transmembrane helices predicted for EAM_3359 by TMHMM2.0 at aa 10-32, 63-85, 130-152, 173-195, 252-274, 281-303, 325-347, 354-376, 380-399, 419-438, 483-505 and 526-548 716540017203 Signal peptide predicted for EAM_3359 by SignalP 2.0 HMM (Signal peptide probability 0.851) with cleavage site probability 0.309 between residues 20 and 21 716540017204 1 transmembrane helix predicted for EAM_3360 by TMHMM2.0 at aa 20-42 716540017205 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 716540017206 active site 716540017207 HMMPfam hit to PF01156, Inosine-uridine preferring nucleoside hy, score 6.2e-65 716540017208 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 716540017209 HMMPfam hit to PF07338, Protein of unknown function (DUF1471), score 0.00012 716540017210 Signal peptide predicted for EAM_3363 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.623 between residues 24 and 25 716540017211 1 transmembrane helix predicted for EAM_3363 by TMHMM2.0 at aa 7-29 716540017212 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 716540017213 HMMPfam hit to PF02321, Outer membrane efflux protein, score 7.3e-60 716540017214 HMMPfam hit to PF02321, Outer membrane efflux protein, score 1.4e-52 716540017215 1 transmembrane helix predicted for EAM_3364 by TMHMM2.0 at aa 7-29 716540017216 Signal peptide predicted for EAM_3364 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.995 between residues 26 and 27 716540017217 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 716540017218 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 716540017219 HlyD family secretion protein; Region: HlyD_3; pfam13437 716540017220 PS00543 HlyD family secretion proteins signature. 716540017221 HMMPfam hit to PF00529, HlyD family secretion protein, score 1.3e-80 716540017222 PS00044 Bacterial regulatory proteins, lysR family signature. 716540017223 1 transmembrane helix predicted for EAM_3365 by TMHMM2.0 at aa 28-47 716540017224 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 716540017225 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 716540017226 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 716540017227 Walker A/P-loop; other site 716540017228 ATP binding site [chemical binding]; other site 716540017229 Q-loop/lid; other site 716540017230 ABC transporter signature motif; other site 716540017231 Walker B; other site 716540017232 D-loop; other site 716540017233 HMMPfam hit to PF00005, ABC transporter, score 3.7e-56 716540017234 PS00211 ABC transporters family signature. 716540017235 PS00017 ATP/GTP-binding site motif A (P-loop). 716540017236 5 transmembrane helices predicted for EAM_3366 by TMHMM2.0 at aa 24-46, 56-78, 130-152, 156-178 and 254-276 716540017237 Protease inhibitor Inh; Region: Inh; pfam02974 716540017238 HMMPfam hit to PF02974, Protease inhibitor Inh, score 7.3e-36 716540017239 1 transmembrane helix predicted for EAM_3367 by TMHMM2.0 at aa 13-35 716540017240 Signal peptide predicted for EAM_3367 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.875 between residues 28 and 29 716540017241 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 716540017242 active site 716540017243 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 716540017244 PS00330 Hemolysin-type calcium-binding region signature. 716540017245 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 3.7e-05 716540017246 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 0.00062 716540017247 HMMPfam hit to PF00413, Matrixin, score 0.00015 716540017248 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 716540017249 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 716540017250 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 716540017251 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 716540017252 Domain of unknown function DUF; Region: DUF204; pfam02659 716540017253 Domain of unknown function DUF; Region: DUF204; pfam02659 716540017254 6 transmembrane helices predicted for EAM_3371 by TMHMM2.0 at aa 4-26, 39-61, 66-85, 105-127, 137-159 and 166-188 716540017255 HMMPfam hit to PF02659, Domain of unknown function DUF, score 9.5e-21 716540017256 HMMPfam hit to PF02659, Domain of unknown function DUF, score 2.7e-27 716540017257 Signal peptide predicted for EAM_3371 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.971 between residues 19 and 20 716540017258 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 716540017259 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 716540017260 metal binding site [ion binding]; metal-binding site 716540017261 dimer interface [polypeptide binding]; other site 716540017262 HMMPfam hit to PF01546, Peptidase family M20/M25/M40, score 5.7e-15 716540017263 HMMPfam hit to PF07687, Peptidase dimerisation domain, score 0.00092 716540017264 PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 716540017265 Signal peptide predicted for EAM_3372 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.828 between residues 23 and 24 716540017266 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 716540017267 HMMPfam hit to PF06643, Protein of unknown function (DUF1158), score 8.1e-32 716540017268 Signal peptide predicted for EAM_3373 by SignalP 2.0 HMM (Signal peptide probability 0.949) with cleavage site probability 0.440 between residues 24 and 25 716540017269 2 transmembrane helices predicted for EAM_3373 by TMHMM2.0 at aa 13-32 and 47-69 716540017270 magnesium-transporting ATPase; Provisional; Region: PRK15122 716540017271 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 716540017272 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 716540017273 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 716540017274 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716540017275 motif II; other site 716540017276 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 716540017277 10 transmembrane helices predicted for EAM_3374 by TMHMM2.0 at aa 71-93, 103-122, 239-261, 281-303, 310-332, 704-726, 759-781, 796-815, 827-849 and 859-881 716540017278 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 4e-21 716540017279 PS00154 E1-E2 ATPases phosphorylation site. 716540017280 HMMPfam hit to PF00122, E1-E2 ATPase, score 3.5e-64 716540017281 HMMPfam hit to PF00690, Cation transporter/ATPase, N-terminus, score 1e-19 716540017282 MgtC family; Region: MgtC; pfam02308 716540017283 HMMPfam hit to PF02308, MgtC family, score 2e-20 716540017284 2 transmembrane helices predicted for EAM_3375 by TMHMM2.0 at aa 30-52 and 62-83 716540017285 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540017286 metabolite-proton symporter; Region: 2A0106; TIGR00883 716540017287 putative substrate translocation pore; other site 716540017288 HMMPfam hit to PF00083, Sugar (and other) transporter, score 8.7e-26 716540017289 11 transmembrane helices predicted for EAM_3376 by TMHMM2.0 at aa 20-42, 62-83, 90-112, 162-184, 191-213, 242-264, 285-307, 317-335, 342-364, 374-396 and 403-425 716540017290 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.3e-22 716540017291 PS00359 Ribosomal protein L11 signature. 716540017292 PS00216 Sugar transport proteins signature 1. 716540017293 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 716540017294 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 716540017295 2 transmembrane helices predicted for EAM_3377 by TMHMM2.0 at aa 7-29 and 645-667 716540017296 HMMPfam hit to PF05170, AsmA family, score 1.8e-164 716540017297 Signal peptide predicted for EAM_3377 by SignalP 2.0 HMM (Signal peptide probability 0.862) with cleavage site probability 0.422 between residues 27 and 28 716540017298 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 716540017299 HMMPfam hit to PF00563, EAL domain, score 2.9e-18 716540017300 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 716540017301 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 716540017302 HMMPfam hit to PF05193, Peptidase M16 inactive domain, score 1.2e-14 716540017303 HMMPfam hit to PF00675, Insulinase (Peptidase family M16), score 0.044 716540017304 Signal peptide predicted for EAM_3379 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 23 and 24 716540017305 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 716540017306 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 716540017307 HMMPfam hit to PF00375, Sodium:dicarboxylate symporter family, score 6.8e-208 716540017308 8 transmembrane helices predicted for EAM_3380 by TMHMM2.0 at aa 5-27, 47-64, 77-99, 141-163, 184-206, 219-241, 326-348 and 352-374 716540017309 PS00714 Sodium:dicarboxylate symporter family signature 2. 716540017310 PS00713 Sodium:dicarboxylate symporter family signature 1. 716540017311 putative diguanylate cyclase; Provisional; Region: PRK13561 716540017312 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 716540017313 metal binding site [ion binding]; metal-binding site 716540017314 active site 716540017315 I-site; other site 716540017316 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 716540017317 HMMPfam hit to PF00563, EAL domain, score 9.4e-88 716540017318 HMMPfam hit to PF00990, GGDEF domain, score 2.3e-08 716540017319 HMMPfam hit to PF00672, HAMP domain, score 2e-07 716540017320 2 transmembrane helices predicted for EAM_3381 by TMHMM2.0 at aa 13-35 and 151-173 716540017321 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 716540017322 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 716540017323 HMMPfam hit to PF01270, Glycosyl hydrolases family, score 7.2e-137 716540017324 PS00812 Glycosyl hydrolases family 8 signature. 716540017325 Signal peptide predicted for EAM_3383 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.995 between residues 22 and 23 716540017326 Cellulose synthase subunit D; Region: Cellsynth_D; pfam03500 716540017327 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 716540017328 HMMPfam hit to PF05420, Cellulose synthase operon protein C C-termin, score 9e-70 716540017329 PS00092 N-6 Adenine-specific DNA methylases signature. 716540017330 HMMPfam hit to PF07721, Tetratricopeptide repeat, score 0.0023 716540017331 HMMPfam hit to PF07721, Tetratricopeptide repeat, score 0.028 716540017332 Signal peptide predicted for EAM_3385 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.983 between residues 33 and 34 716540017333 cellulose synthase regulator protein; Provisional; Region: PRK11114 716540017334 1 transmembrane helix predicted for EAM_3386 by TMHMM2.0 at aa 784-806 716540017335 HMMPfam hit to PF03170, Bacterial cellulose synthase subunit, score 3.6e-71 716540017336 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 716540017337 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. 716540017338 Signal peptide predicted for EAM_3386 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.967 between residues 22 and 23 716540017339 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 716540017340 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 716540017341 DXD motif; other site 716540017342 PilZ domain; Region: PilZ; pfam07238 716540017343 HMMPfam hit to PF07238, PilZ domain, score 3.2e-08 716540017344 9 transmembrane helices predicted for EAM_3387 by TMHMM2.0 at aa 5-25, 30-47, 52-69, 84-106, 376-398, 408-430, 442-464, 489-511 and 523-545 716540017345 HMMPfam hit to PF00535, Glycosyl transferase family, score 3.7e-21 716540017346 Signal peptide predicted for EAM_3387 by SignalP 2.0 HMM (Signal peptide probability 0.941) with cleavage site probability 0.412 between residues 18 and 19 716540017347 cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371 716540017348 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 716540017349 P-loop; other site 716540017350 Magnesium ion binding site [ion binding]; other site 716540017351 HMMPfam hit to PF01656, CobQ/CobB/MinD/ParA nucleotide binding domai, score 6e-14 716540017352 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 716540017353 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 716540017354 Walker A/P-loop; other site 716540017355 ATP binding site [chemical binding]; other site 716540017356 Q-loop/lid; other site 716540017357 ABC transporter signature motif; other site 716540017358 Walker B; other site 716540017359 D-loop; other site 716540017360 H-loop/switch region; other site 716540017361 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 716540017362 HMMPfam hit to PF08352, Oligopeptide/dipeptide transporter, C-termi, score 4.8e-32 716540017363 HMMPfam hit to PF00005, ABC transporter, score 8.9e-61 716540017364 PS00211 ABC transporters family signature. 716540017365 PS00017 ATP/GTP-binding site motif A (P-loop). 716540017366 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 716540017367 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 716540017368 Walker A/P-loop; other site 716540017369 ATP binding site [chemical binding]; other site 716540017370 Q-loop/lid; other site 716540017371 ABC transporter signature motif; other site 716540017372 Walker B; other site 716540017373 D-loop; other site 716540017374 H-loop/switch region; other site 716540017375 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 716540017376 HMMPfam hit to PF08352, Oligopeptide/dipeptide transporter, C-termi, score 1.2e-26 716540017377 HMMPfam hit to PF00005, ABC transporter, score 2.5e-61 716540017378 PS00211 ABC transporters family signature. 716540017379 PS00017 ATP/GTP-binding site motif A (P-loop). 716540017380 dipeptide transporter; Provisional; Region: PRK10913 716540017381 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 716540017382 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540017383 dimer interface [polypeptide binding]; other site 716540017384 conserved gate region; other site 716540017385 putative PBP binding loops; other site 716540017386 ABC-ATPase subunit interface; other site 716540017387 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 5.2e-46 716540017388 5 transmembrane helices predicted for EAM_3392 by TMHMM2.0 at aa 31-53, 103-125, 140-162, 210-232 and 265-287 716540017389 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 716540017390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540017391 dimer interface [polypeptide binding]; other site 716540017392 conserved gate region; other site 716540017393 putative PBP binding loops; other site 716540017394 ABC-ATPase subunit interface; other site 716540017395 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 2.3e-55 716540017396 6 transmembrane helices predicted for EAM_3393 by TMHMM2.0 at aa 9-31, 98-120, 133-155, 202-221, 258-280 and 309-331 716540017397 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 716540017398 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 716540017399 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 716540017400 peptide binding site [polypeptide binding]; other site 716540017401 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 3.4e-97 716540017402 Signal peptide predicted for EAM_3394 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 28 and 29 716540017403 phosphoethanolamine transferase; Provisional; Region: PRK11560 716540017404 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 716540017405 Sulfatase; Region: Sulfatase; pfam00884 716540017406 HMMPfam hit to PF00884, Sulfatase, score 8.2e-67 716540017407 PS00017 ATP/GTP-binding site motif A (P-loop). 716540017408 5 transmembrane helices predicted for EAM_3396 by TMHMM2.0 at aa 12-31, 46-68, 81-103, 118-140 and 161-178 716540017409 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 716540017410 HMMPfam hit to PF02566, OsmC-like protein, score 5.7e-32 716540017411 Transcriptional regulators [Transcription]; Region: MarR; COG1846 716540017412 MarR family; Region: MarR; pfam01047 716540017413 HMMPfam hit to PF01047, MarR family, score 1.6e-25 716540017414 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 716540017415 HD domain; Region: HD_4; pfam13328 716540017416 1 transmembrane helix predicted for EAM_3401 by TMHMM2.0 at aa 7-29 716540017417 Signal peptide predicted for EAM_3401 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 24 and 25 716540017418 Predicted amidohydrolase [General function prediction only]; Region: COG0388 716540017419 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 716540017420 active site 716540017421 catalytic triad [active] 716540017422 dimer interface [polypeptide binding]; other site 716540017423 HMMPfam hit to PF00795, Carbon-nitrogen hydrolase, score 1.6e-32 716540017424 HNH endonuclease; Region: HNH_2; pfam13391 716540017425 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 716540017426 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 716540017427 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 716540017428 HMMPfam hit to PF02086, D12 class N6 adenine-specific DNA met, score 6.1e-14 716540017429 PS00092 N-6 Adenine-specific DNA methylases signature. 716540017430 HMMPfam hit to PF02086, D12 class N6 adenine-specific DNA met, score 6.5e-41 716540017431 PS00092 N-6 Adenine-specific DNA methylases signature. 716540017432 PS00012 Phosphopantetheine attachment site. 716540017433 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 716540017434 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 716540017435 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 716540017436 HMMPfam hit to PF01232, Mannitol dehydrogenase Rossmann domain, score 2.8e-45 716540017437 HMMPfam hit to PF08125, Mannitol dehydrogenase C-terminal domai, score 1.8e-60 716540017438 Uncharacterized conserved protein [Function unknown]; Region: COG4095 716540017439 Signal peptide predicted for EAM_3409 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.482 between residues 32 and 33 716540017440 4 transmembrane helices predicted for EAM_3409 by TMHMM2.0 at aa 5-27, 31-48, 55-77 and 81-103 716540017441 HMMPfam hit to PF03083, MtN3/saliva family, score 0.00025 716540017442 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 716540017443 Acyltransferase family; Region: Acyl_transf_3; pfam01757 716540017444 10 transmembrane helices predicted for EAM_3410 by TMHMM2.0 at aa 13-35, 45-67, 79-100, 115-134, 141-158, 168-190, 203-222, 232-254, 266-288 and 303-321 716540017445 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 716540017446 dimer interface [polypeptide binding]; other site 716540017447 motif 1; other site 716540017448 active site 716540017449 motif 2; other site 716540017450 motif 3; other site 716540017451 HMMPfam hit to PF02091, Glycyl-tRNA synthetase alpha subunit, score 7.7e-248 716540017452 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 716540017453 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 716540017454 DALR anticodon binding domain; Region: DALR_1; pfam05746 716540017455 HMMPfam hit to PF02092, Glycyl-tRNA synthetase beta subunit, score 0 716540017456 HMMPfam hit to PF05746, DALR anticodon binding domain, score 7.9e-06 716540017457 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 716540017458 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 716540017459 putative NAD(P) binding site [chemical binding]; other site 716540017460 putative substrate binding site [chemical binding]; other site 716540017461 catalytic Zn binding site [ion binding]; other site 716540017462 structural Zn binding site [ion binding]; other site 716540017463 dimer interface [polypeptide binding]; other site 716540017464 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like domain, score 1.9e-31 716540017465 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 716540017466 PS00190 Cytochrome c family heme-binding site signature. 716540017467 PS00059 Zinc-containing alcohol dehydrogenases signature. 716540017468 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 1.6e-31 716540017469 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 716540017470 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 716540017471 non-specific DNA binding site [nucleotide binding]; other site 716540017472 salt bridge; other site 716540017473 sequence-specific DNA binding site [nucleotide binding]; other site 716540017474 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 716540017475 Signal peptide predicted for EAM_3415 by SignalP 2.0 HMM (Signal peptide probability 0.725) with cleavage site probability 0.640 between residues 27 and 28 716540017476 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 716540017477 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 716540017478 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 716540017479 active site 716540017480 P-loop; other site 716540017481 phosphorylation site [posttranslational modification] 716540017482 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 716540017483 active site 716540017484 phosphorylation site [posttranslational modification] 716540017485 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 5.8e-21 716540017486 9 transmembrane helices predicted for EAM_3416 by TMHMM2.0 at aa 21-43, 53-75, 88-110, 130-152, 159-181, 214-236, 243-265, 270-292 and 313-335 716540017487 HMMPfam hit to PF02302, PTS system, Lactose/Cellobiose specific II, score 2.4e-17 716540017488 HMMPfam hit to PF00359, Phosphoenolpyruvate-dependent sugar phosph, score 5e-73 716540017489 PS00372 PTS EIIA domains phosphorylation site signature 2. 716540017490 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 716540017491 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 716540017492 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 716540017493 HMMPfam hit to PF01232, Mannitol dehydrogenase Rossmann domain, score 7.4e-44 716540017494 HMMPfam hit to PF08125, Mannitol dehydrogenase C-terminal domai, score 9.8e-99 716540017495 PS00974 Mannitol dehydrogenases signature. 716540017496 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 716540017497 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 716540017498 HMMPfam hit to PF05068, Mannitol repressor, score 7.9e-84 716540017499 hypothetical protein; Provisional; Region: PRK11020 716540017500 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 716540017501 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 716540017502 DNA binding residues [nucleotide binding] 716540017503 dimerization interface [polypeptide binding]; other site 716540017504 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR family, score 1.2e-14 716540017505 PS00622 Bacterial regulatory proteins, luxR family signature. 716540017506 FaeA-like protein; Region: FaeA; pfam04703 716540017507 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 716540017508 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 716540017509 DNA binding site [nucleotide binding] 716540017510 HMMPfam hit to PF00486, Transcriptional regulatory protein, C ter, score 5.9e-11 716540017511 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 716540017512 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 716540017513 putative ligand binding site [chemical binding]; other site 716540017514 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 0.0018 716540017515 1 transmembrane helix predicted for EAM_3423 by TMHMM2.0 at aa 5-27 716540017516 Signal peptide predicted for EAM_3423 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 21 and 22 716540017517 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 716540017518 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 716540017519 TM-ABC transporter signature motif; other site 716540017520 10 transmembrane helices predicted for EAM_3424 by TMHMM2.0 at aa 21-40, 50-72, 79-101, 106-128, 135-157, 177-199, 231-253, 257-279, 286-303 and 307-329 716540017521 HMMPfam hit to PF02653, Branched-chain amino acid transport syst, score 1.3e-45 716540017522 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 716540017523 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 716540017524 Walker A/P-loop; other site 716540017525 ATP binding site [chemical binding]; other site 716540017526 Q-loop/lid; other site 716540017527 ABC transporter signature motif; other site 716540017528 Walker B; other site 716540017529 D-loop; other site 716540017530 H-loop/switch region; other site 716540017531 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 716540017532 HMMPfam hit to PF00005, ABC transporter, score 6.7e-21 716540017533 PS00211 ABC transporters family signature. 716540017534 PS00017 ATP/GTP-binding site motif A (P-loop). 716540017535 HMMPfam hit to PF00005, ABC transporter, score 3.5e-43 716540017536 PS00017 ATP/GTP-binding site motif A (P-loop). 716540017537 superoxide dismutase; Provisional; Region: PRK10925 716540017538 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 716540017539 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 716540017540 HMMPfam hit to PF02777, Iron/manganese superoxide dismutases, C-term, score 1.2e-59 716540017541 PS00088 Manganese and iron superoxide dismutases signature. 716540017542 HMMPfam hit to PF00081, Iron/manganese superoxide dismutases, alpha-, score 3.3e-55 716540017543 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 716540017544 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 716540017545 inhibitor-cofactor binding pocket; inhibition site 716540017546 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716540017547 catalytic residue [active] 716540017548 HMMPfam hit to PF00202, Aminotransferase class-III, score 6.1e-61 716540017549 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 716540017550 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 716540017551 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 716540017552 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 716540017553 HMMPfam hit to PF08220, DeoR-like helix-turn-helix domain, score 9.2e-14 716540017554 HMMPfam hit to PF08279, HTH domain, score 0.00043 716540017555 PS00894 Bacterial regulatory proteins, deoR family signature. 716540017556 HMMPfam hit to PF00455, Bacterial regulatory proteins, deoR family, score 1.7e-39 716540017557 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 716540017558 HMMPfam hit to PF02634, FdhD/NarQ family, score 1.7e-121 716540017559 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 716540017560 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 716540017561 HMMPfam hit to PF04216, Protein involved in formate dehydrogenase fo, score 1e-154 716540017562 putative glutathione S-transferase; Provisional; Region: PRK10357 716540017563 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 716540017564 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 716540017565 dimer interface [polypeptide binding]; other site 716540017566 N-terminal domain interface [polypeptide binding]; other site 716540017567 putative substrate binding pocket (H-site) [chemical binding]; other site 716540017568 HMMPfam hit to PF00043, Glutathione S-transferase, C-terminal domain, score 1.1e-11 716540017569 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 716540017570 HMMPfam hit to PF03352, Methyladenine glycosylase, score 3.6e-116 716540017571 putative outer membrane lipoprotein; Provisional; Region: PRK10510 716540017572 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 716540017573 ligand binding site [chemical binding]; other site 716540017574 Signal peptide predicted for EAM_3434 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.532 between residues 21 and 22 716540017575 3 transmembrane helices predicted for EAM_3434 by TMHMM2.0 at aa 5-27, 37-56 and 63-85 716540017576 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540017577 PS00017 ATP/GTP-binding site motif A (P-loop). 716540017578 HMMPfam hit to PF05433, Rickettsia 17 kDa surface antigen, score 3.7e-09 716540017579 HMMPfam hit to PF00691, OmpA family, score 1.9e-40 716540017580 PS01068 OmpA-like domain. 716540017581 Transcriptional regulators [Transcription]; Region: PurR; COG1609 716540017582 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 716540017583 DNA binding site [nucleotide binding] 716540017584 domain linker motif; other site 716540017585 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 716540017586 putative dimerization interface [polypeptide binding]; other site 716540017587 putative ligand binding site [chemical binding]; other site 716540017588 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 2.8e-05 716540017589 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 2.9e-08 716540017590 Protein-tyrosine phosphatase; Region: Y_phosphatase; pfam00102 716540017591 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cd00047 716540017592 active site 716540017593 HMMPfam hit to PF00102, Protein-tyrosine phosphatase, score 2.4e-27 716540017594 PS00383 Tyrosine specific protein phosphatases active site. 716540017595 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 716540017596 HMMPfam hit to PF01261, Xylose isomerase-like TIM barrel, score 0.0017 716540017597 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 716540017598 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 716540017599 substrate binding site [chemical binding]; other site 716540017600 ATP binding site [chemical binding]; other site 716540017601 HMMPfam hit to PF00294, pfkB family carbohydrate kinase, score 5.4e-65 716540017602 PS00584 pfkB family of carbohydrate kinases signature 2. 716540017603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716540017604 D-galactonate transporter; Region: 2A0114; TIGR00893 716540017605 putative substrate translocation pore; other site 716540017606 12 transmembrane helices predicted for EAM_3440 by TMHMM2.0 at aa 12-30, 50-72, 81-100, 110-132, 145-167, 171-189, 232-254, 269-291, 298-320, 324-346, 359-381 and 391-410 716540017607 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.1e-62 716540017608 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 716540017609 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 716540017610 dimerization interface [polypeptide binding]; other site 716540017611 ligand binding site [chemical binding]; other site 716540017612 NADP binding site [chemical binding]; other site 716540017613 catalytic site [active] 716540017614 HMMPfam hit to PF00389, D-isomer specific 2-hydroxyacid dehydrog, score 3.9e-37 716540017615 HMMPfam hit to PF02826, D-isomer specific 2-hydroxyacid dehydrog, score 1.3e-84 716540017616 PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 716540017617 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 716540017618 active site 716540017619 catalytic residues [active] 716540017620 Signal peptide predicted for EAM_3444 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.992 between residues 20 and 21 716540017621 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 716540017622 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 716540017623 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716540017624 homodimer interface [polypeptide binding]; other site 716540017625 catalytic residue [active] 716540017626 HMMPfam hit to PF00155, Aminotransferase class I and II, score 4.8e-08 716540017627 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 716540017628 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 716540017629 putative dimer interface [polypeptide binding]; other site 716540017630 HMMPfam hit to PF00011, Hsp20/alpha crystallin family, score 1.7e-25 716540017631 Protein of unknown function (DUF1375); Region: DUF1375; cl11456 716540017632 Signal peptide predicted for EAM_3447 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.493 between residues 31 and 32 716540017633 HMMPfam hit to PF07119, Protein of unknown function (DUF1375), score 1.4e-26 716540017634 1 transmembrane helix predicted for EAM_3447 by TMHMM2.0 at aa 7-29 716540017635 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540017636 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 716540017637 sugar phosphate phosphatase; Provisional; Region: PRK10513 716540017638 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716540017639 active site 716540017640 motif I; other site 716540017641 motif II; other site 716540017642 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716540017643 HMMPfam hit to PF05116, Sucrose-6F-phosphate phosphohydrolase, score 1.9e-06 716540017644 HMMPfam hit to PF08282, haloacid dehalogenase-like hydrolase, score 2.3e-85 716540017645 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 1.4e-11 716540017646 PS01229 Hypothetical cof family signature 2. 716540017647 PS01228 Hypothetical cof family signature 1. 716540017648 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 716540017649 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716540017650 ATP binding site [chemical binding]; other site 716540017651 Mg2+ binding site [ion binding]; other site 716540017652 G-X-G motif; other site 716540017653 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 716540017654 anchoring element; other site 716540017655 dimer interface [polypeptide binding]; other site 716540017656 ATP binding site [chemical binding]; other site 716540017657 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 716540017658 active site 716540017659 putative metal-binding site [ion binding]; other site 716540017660 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 716540017661 HMMPfam hit to PF00986, DNA gyrase B subunit, carboxyl terminus, score 1.3e-46 716540017662 HMMPfam hit to PF01751, Toprim domain, score 1.9e-05 716540017663 PS00177 DNA topoisomerase II signature. 716540017664 HMMPfam hit to PF00204, DNA gyrase B, score 3.3e-95 716540017665 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and H, score 1.6e-33 716540017666 recF protein; Region: recf; TIGR00611 716540017667 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716540017668 Walker A/P-loop; other site 716540017669 ATP binding site [chemical binding]; other site 716540017670 Q-loop/lid; other site 716540017671 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716540017672 ABC transporter signature motif; other site 716540017673 Walker B; other site 716540017674 D-loop; other site 716540017675 H-loop/switch region; other site 716540017676 HMMPfam hit to PF02463, RecF/RecN/SMC N terminal domain, score 1.9e-55 716540017677 PS00618 RecF protein signature 2. 716540017678 PS00617 RecF protein signature 1. 716540017679 PS00017 ATP/GTP-binding site motif A (P-loop). 716540017680 DNA polymerase III subunit beta; Validated; Region: PRK05643 716540017681 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 716540017682 putative DNA binding surface [nucleotide binding]; other site 716540017683 dimer interface [polypeptide binding]; other site 716540017684 beta-clamp/clamp loader binding surface; other site 716540017685 beta-clamp/translesion DNA polymerase binding surface; other site 716540017686 HMMPfam hit to PF02768, DNA polymerase III beta subunit, C-te, score 1.1e-60 716540017687 HMMPfam hit to PF02767, DNA polymerase III beta subunit, cent, score 9.4e-66 716540017688 HMMPfam hit to PF00712, DNA polymerase III beta subunit, N-te, score 1.9e-63 716540017689 DnaA N-terminal domain; Region: DnaA_N; pfam11638 716540017690 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 716540017691 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716540017692 Walker A motif; other site 716540017693 ATP binding site [chemical binding]; other site 716540017694 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 716540017695 Walker B motif; other site 716540017696 arginine finger; other site 716540017697 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 716540017698 DnaA box-binding interface [nucleotide binding]; other site 716540017699 HMMPfam hit to PF08299, Bacterial dnaA protein helix-turn-helix, score 6.8e-48 716540017700 PS01008 DnaA protein signature. 716540017701 HMMPfam hit to PF00308, Bacterial dnaA protein, score 5.9e-152 716540017702 PS00017 ATP/GTP-binding site motif A (P-loop). 716540017703 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 716540017704 HMMPfam hit to PF00468, Ribosomal protein L34, score 1.1e-20 716540017705 PS00784 Ribosomal protein L34 signature. 716540017706 ribonuclease P; Reviewed; Region: rnpA; PRK01732 716540017707 HMMPfam hit to PF00825, Ribonuclease P, score 4e-61 716540017708 PS00648 Bacterial ribonuclease P protein component signature. 716540017709 hypothetical protein; Validated; Region: PRK00041 716540017710 HMMPfam hit to PF01809, Domain of unknown function DUF37, score 1.1e-45 716540017711 membrane protein insertase; Provisional; Region: PRK01318 716540017712 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 716540017713 Signal peptide predicted for EAM_3457 by SignalP 2.0 HMM (Signal peptide probability 0.978) with cleavage site probability 0.512 between residues 21 and 22 716540017714 5 transmembrane helices predicted for EAM_3457 by TMHMM2.0 at aa 7-24, 350-372, 417-439, 459-478 and 497-519 716540017715 HMMPfam hit to PF02096, 60Kd inner membrane protein, score 2e-124 716540017716 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 716540017717 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 716540017718 trmE is a tRNA modification GTPase; Region: trmE; cd04164 716540017719 G1 box; other site 716540017720 GTP/Mg2+ binding site [chemical binding]; other site 716540017721 Switch I region; other site 716540017722 G2 box; other site 716540017723 Switch II region; other site 716540017724 G3 box; other site 716540017725 G4 box; other site 716540017726 G5 box; other site 716540017727 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 716540017728 HMMPfam hit to PF01926, GTPase of unknown function, score 1.6e-41 716540017729 PS00017 ATP/GTP-binding site motif A (P-loop). 716540017730 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 716540017731 PS00678 Trp-Asp (WD) repeats signature. 716540017732 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 716540017733 13 transmembrane helices predicted for EAM_3460 by TMHMM2.0 at aa 20-39, 54-76, 78-100, 105-127, 134-151, 166-188, 195-214, 245-267, 287-309, 319-341, 346-368, 383-405 and 417-434 716540017734 HMMPfam hit to PF00916, Sulfate transporter family, score 0.0017 716540017735 HMMPfam hit to PF00860, Permease family, score 2.5e-27 716540017736 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 716540017737 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 716540017738 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 716540017739 non-specific DNA interactions [nucleotide binding]; other site 716540017740 DNA binding site [nucleotide binding] 716540017741 sequence specific DNA binding site [nucleotide binding]; other site 716540017742 putative cAMP binding site [chemical binding]; other site 716540017743 HMMPfam hit to PF03811, Insertion element protein, score 2e-25 716540017744 benzoate transport; Region: 2A0115; TIGR00895 716540017745 Signal peptide predicted for EAM_3462 by SignalP 2.0 HMM (Signal peptide probability 0.868) with cleavage site probability 0.449 between residues 18 and 19 716540017746 PS00228 Tubulin-beta mRNA autoregulation signal. 716540017747 transcriptional regulator PhoU; Provisional; Region: PRK11115 716540017748 PhoU domain; Region: PhoU; pfam01895 716540017749 PhoU domain; Region: PhoU; pfam01895 716540017750 HMMPfam hit to PF01895, PhoU family, score 9.1e-31 716540017751 HMMPfam hit to PF01895, PhoU family, score 4e-33 716540017752 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 716540017753 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 716540017754 Walker A/P-loop; other site 716540017755 ATP binding site [chemical binding]; other site 716540017756 Q-loop/lid; other site 716540017757 ABC transporter signature motif; other site 716540017758 Walker B; other site 716540017759 D-loop; other site 716540017760 H-loop/switch region; other site 716540017761 HMMPfam hit to PF00005, ABC transporter, score 4.9e-69 716540017762 PS00211 ABC transporters family signature. 716540017763 PS00017 ATP/GTP-binding site motif A (P-loop). 716540017764 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 716540017765 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540017766 dimer interface [polypeptide binding]; other site 716540017767 conserved gate region; other site 716540017768 putative PBP binding loops; other site 716540017769 ABC-ATPase subunit interface; other site 716540017770 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 2.3e-38 716540017771 6 transmembrane helices predicted for EAM_3465 by TMHMM2.0 at aa 29-51, 88-110, 123-145, 150-169, 201-223 and 268-290 716540017772 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 716540017773 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 716540017774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716540017775 dimer interface [polypeptide binding]; other site 716540017776 conserved gate region; other site 716540017777 putative PBP binding loops; other site 716540017778 ABC-ATPase subunit interface; other site 716540017779 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 7.7e-12 716540017780 6 transmembrane helices predicted for EAM_3466 by TMHMM2.0 at aa 21-43, 78-100, 112-134, 166-188, 227-249 and 290-312 716540017781 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 716540017782 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 716540017783 substrate binding pocket [chemical binding]; other site 716540017784 membrane-bound complex binding site; other site 716540017785 hinge residues; other site 716540017786 HMMPfam hit to PF01547, Bacterial extracellular solute-binding prot, score 2e-28 716540017787 PS00017 ATP/GTP-binding site motif A (P-loop). 716540017788 Signal peptide predicted for EAM_3467 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.991 between residues 22 and 23 716540017789 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 716540017790 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 716540017791 active site 716540017792 HMMPfam hit to PF02435, Levansucrase/Invertase, score 2.3e-268 716540017793 Phage holin family (Lysis protein S); Region: Phage_holin_3; pfam05106 716540017794 HMMPfam hit to PF05106, Phage holin family (Lysis protein S), score 7e-07 716540017795 3 transmembrane helices predicted for EAM_3469 by TMHMM2.0 at aa 15-35, 48-70 and 74-96 716540017796 3 transmembrane helices predicted for EAM_3470 by TMHMM2.0 at aa 20-37, 42-61 and 82-99 716540017797 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 716540017798 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 716540017799 glutaminase active site [active] 716540017800 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 716540017801 dimer interface [polypeptide binding]; other site 716540017802 active site 716540017803 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 716540017804 dimer interface [polypeptide binding]; other site 716540017805 active site 716540017806 HMMPfam hit to PF01380, SIS domain, score 9.9e-38 716540017807 HMMPfam hit to PF01380, SIS domain, score 5.5e-43 716540017808 HMMPfam hit to PF00310, Glutamine amidotransferases class-II, score 1.4e-51 716540017809 PS00443 Glutamine amidotransferases class-II active site. 716540017810 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 716540017811 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 716540017812 Substrate binding site; other site 716540017813 Mg++ binding site; other site 716540017814 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 716540017815 active site 716540017816 substrate binding site [chemical binding]; other site 716540017817 CoA binding site [chemical binding]; other site 716540017818 PS00101 Hexapeptide-repeat containing-transferases signature. 716540017819 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (th, score 20 716540017820 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (th, score 9.5 716540017821 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (th, score 4.4 716540017822 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (th, score 35 716540017823 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (th, score 0.6 716540017824 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (th, score 0.18 716540017825 HMMPfam hit to PF00483, Nucleotidyl transferase, score 7e-08 716540017826 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 716540017827 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 716540017828 gamma subunit interface [polypeptide binding]; other site 716540017829 epsilon subunit interface [polypeptide binding]; other site 716540017830 LBP interface [polypeptide binding]; other site 716540017831 HMMPfam hit to PF00401, ATP synthase, Delta/Epsilon chain, long, score 1.8e-13 716540017832 HMMPfam hit to PF02823, ATP synthase, Delta/Epsilon chain, beta, score 2.3e-31 716540017833 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 716540017834 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 716540017835 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 716540017836 alpha subunit interaction interface [polypeptide binding]; other site 716540017837 Walker A motif; other site 716540017838 ATP binding site [chemical binding]; other site 716540017839 Walker B motif; other site 716540017840 inhibitor binding site; inhibition site 716540017841 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 716540017842 HMMPfam hit to PF00306, ATP synthase alpha/beta chain, C termin, score 5.4e-46 716540017843 HMMPfam hit to PF00006, ATP synthase alpha/beta family, nucleot, score 1.7e-93 716540017844 PS00152 ATP synthase alpha and beta subunits signature. 716540017845 PS00017 ATP/GTP-binding site motif A (P-loop). 716540017846 HMMPfam hit to PF02874, ATP synthase alpha/beta family, beta-ba, score 1.3e-24 716540017847 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 716540017848 core domain interface [polypeptide binding]; other site 716540017849 delta subunit interface [polypeptide binding]; other site 716540017850 epsilon subunit interface [polypeptide binding]; other site 716540017851 HMMPfam hit to PF00231, ATP synthase, score 9.1e-167 716540017852 PS00153 ATP synthase gamma subunit signature. 716540017853 PS00041 Bacterial regulatory proteins, araC family signature. 716540017854 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 716540017855 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 716540017856 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 716540017857 beta subunit interaction interface [polypeptide binding]; other site 716540017858 Walker A motif; other site 716540017859 ATP binding site [chemical binding]; other site 716540017860 Walker B motif; other site 716540017861 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 716540017862 HMMPfam hit to PF00306, ATP synthase alpha/beta chain, C termin, score 3.8e-26 716540017863 HMMPfam hit to PF00006, ATP synthase alpha/beta family, nucleot, score 1.8e-117 716540017864 PS00152 ATP synthase alpha and beta subunits signature. 716540017865 PS00017 ATP/GTP-binding site motif A (P-loop). 716540017866 HMMPfam hit to PF02874, ATP synthase alpha/beta family, beta-ba, score 1.9e-16 716540017867 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 716540017868 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 716540017869 HMMPfam hit to PF00213, ATP synthase delta (OSCP) subunit, score 2.3e-65 716540017870 PS00389 ATP synthase delta (OSCP) subunit signature. 716540017871 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 716540017872 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 716540017873 HMMPfam hit to PF00430, ATP synthase B/B' CF(0), score 1.1e-41 716540017874 Signal peptide predicted for EAM_3478 by SignalP 2.0 HMM (Signal peptide probability 0.865) with cleavage site probability 0.775 between residues 31 and 32 716540017875 1 transmembrane helix predicted for EAM_3478 by TMHMM2.0 at aa 7-29 716540017876 ATP synthase, F0 subunit c; Region: ATP_synt_c; TIGR01260 716540017877 HMMPfam hit to PF00137, ATP synthase subunit C, score 3.2e-24 716540017878 2 transmembrane helices predicted for EAM_3479 by TMHMM2.0 at aa 10-32 and 53-75 716540017879 PS00605 ATP synthase c subunit signature. 716540017880 Signal peptide predicted for EAM_3479 by SignalP 2.0 HMM (Signal peptide probability 0.749) with cleavage site probability 0.528 between residues 23 and 24 716540017881 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 716540017882 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 716540017883 HMMPfam hit to PF00119, ATP synthase A chain, score 3.1e-90 716540017884 5 transmembrane helices predicted for EAM_3480 by TMHMM2.0 at aa 39-61, 101-123, 143-165, 212-234 and 244-266 716540017885 PS00449 ATP synthase a subunit signature. 716540017886 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 716540017887 HMMPfam hit to PF03899, ATP synthase I chain, score 3.2e-38 716540017888 4 transmembrane helices predicted for EAM_3481 by TMHMM2.0 at aa 10-29, 36-58, 73-95 and 100-122 716540017889 Signal peptide predicted for EAM_3481 by SignalP 2.0 HMM (Signal peptide probability 0.717) with cleavage site probability 0.609 between residues 42 and 43 716540017890 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 716540017891 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 716540017892 HMMPfam hit to PF02527, Glucose inhibited division protein, score 6.6e-83 716540017893 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 716540017894 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 716540017895 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 716540017896 HMMPfam hit to PF01134, Glucose inhibited division protein A, score 1.6e-277 716540017897 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 0.00018 716540017898 PS01281 Glucose inhibited division protein A family signature 2. 716540017899 PS01280 Glucose inhibited division protein A family signature 1. 716540017900 Initiator Replication protein; Region: Rep_3; pfam01051 716540017901 HMMPfam hit to PF01051, Initiator Replication protein, score 6.5e-79 716540017902 superfamily hit to SSF46785, ''Winged helix'' DNA-binding domain, score 1.4e-30 716540017903 superfamily hit to SSF46785, ''Winged helix'' DNA-binding domain, score 1.6e-22 716540017904 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 716540017905 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 716540017906 superfamily hit to SSF81273, H-NS histone-like proteins, score 5.2e-13 716540017907 HMMPfam hit to PF00816, H-NS histone family, score 4.2e-49 716540017908 superfamily hit to SSF81273, H-NS histone-like proteins, score 1.1e-15 716540017909 Omptin family; Region: Omptin; cl01886 716540017910 Omptin family; Region: Omptin; cl01886 716540017911 superfamily hit to SSF69917, OMPT-like, score 4.3e-09 716540017912 Signal peptide predicted for EAM_P109 by SignalP 2.0 HMM (Signal peptide probability 0.979) with cleavage site probability 0.912 between residues 24 and 25 716540017913 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716540017914 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716540017915 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 716540017916 putative dimerization interface [polypeptide binding]; other site 716540017917 HMMPfam hit to PF03466, LysR substrate binding domain, score 2.7e-49 716540017918 superfamily hit to SSF53850, Periplasmic binding protein-like II, score 6.4e-40 716540017919 superfamily hit to SSF46785, ''Winged helix'' DNA-binding domain, score 7.6e-25 716540017920 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 8e-20 716540017921 PS00044 Bacterial regulatory proteins, lysR family signature. 716540017922 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 716540017923 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 716540017924 NAD(P) binding site [chemical binding]; other site 716540017925 catalytic residues [active] 716540017926 superfamily hit to SSF53720, ALDH-like, score 1.6e-138 716540017927 HMMPfam hit to PF00171, Aldehyde dehydrogenase family, score 3.6e-151 716540017928 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 716540017929 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 716540017930 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 716540017931 dimer interface [polypeptide binding]; other site 716540017932 putative CheW interface [polypeptide binding]; other site 716540017933 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 3.6e-98 716540017934 2 probable transmembrane helices predicted for EAM_P112 by TMHMM2.0 at aa 10-32 and 186-208 716540017935 Signal peptide predicted for EAM_P112 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.487 between residues 33 and 34 716540017936 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 716540017937 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 716540017938 non-specific DNA binding site [nucleotide binding]; other site 716540017939 salt bridge; other site 716540017940 sequence-specific DNA binding site [nucleotide binding]; other site 716540017941 superfamily hit to SSF47413, lambda repressor-like DNA-binding domains, score 3.4e-07 716540017942 Predicted helix-turn-helix motif with score 1713.000, SD 5.02 at aa 30-51, sequence LSRKTLAIKSGVSESTIKRFEM 716540017943 HipA N-terminal domain; Region: Couple_hipA; pfam13657 716540017944 HipA-like N-terminal domain; Region: HipA_N; pfam07805 716540017945 HipA-like C-terminal domain; Region: HipA_C; pfam07804 716540017946 HMMPfam hit to PF07805, HipA-like N-terminal domain, score 1.4e-14 716540017947 HMMPfam hit to PF07804, HipA-like C-terminal domain, score 6.3e-29 716540017948 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 716540017949 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 716540017950 ATP binding site [chemical binding]; other site 716540017951 substrate interface [chemical binding]; other site 716540017952 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 716540017953 active site residue [active] 716540017954 superfamily hit to SSF52821, Rhodanese/Cell cycle control phosphatase, score 2.6e-07 716540017955 HMMPfam hit to PF05237, MoeZ/MoeB domain, score 7.8e-26 716540017956 superfamily hit to SSF69572, Activating enzymes of the ubiquitin-like proteins, score 3.7e-58 716540017957 HMMPfam hit to PF00899, ThiF family, score 1.1e-55 716540017958 1 probable transmembrane helix predicted for EAM_P117 by TMHMM2.0 at aa 26-48 716540017959 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 716540017960 ThiS interaction site; other site 716540017961 putative active site [active] 716540017962 tetramer interface [polypeptide binding]; other site 716540017963 HMMPfam hit to PF05690, Thiazole biosynthesis protein ThiG, score 1.5e-167 716540017964 superfamily hit to SSF51395, FMN-linked oxidoreductases, score 7.1e-38 716540017965 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 716540017966 thiS-thiF/thiG interaction site; other site 716540017967 superfamily hit to SSF54285, MoaD/ThiS, score 4.2e-10 716540017968 HMMPfam hit to PF02597, ThiS family, score 1e-11; HMMTigr hit to TIGR01683, thiS: thiamine biosynthesis protein ThiS, score 3.3e-18 716540017969 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 716540017970 superfamily hit to SSF51971, Nucleotide-binding domain, score 8.1e-16 716540017971 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 1.6e-38 716540017972 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 716540017973 HMMTigr hit to TIGR01552, phd_fam: prevent-host-death family protein, score 0.00026 716540017974 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 716540017975 putative active site [active] 716540017976 HMMPfam hit to PF01850, PIN domain, score 1.7e-07 716540017977 superfamily hit to SSF88723, PIN domain-like, score 2.3e-05 716540017978 Transposase; Region: HTH_Tnp_1; cl17663 716540017979 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 716540017980 ParG; Region: ParG; pfam09274 716540017981 superfamily hit to SSF47598, Met repressor-like, score 4e-06 716540017982 ParA-like protein; Provisional; Region: PHA02518 716540017983 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 716540017984 P-loop; other site 716540017985 Magnesium ion binding site [ion binding]; other site 716540017986 superfamily hit to SSF52540, P-loop containing nucleoside triphosphate hydrolases, score 6.6e-35 716540017987 HMMPfam hit to PF01656, CobQ/CobB/MinD/ParA nucleotide binding domai, score 4.6e-23 716540017988 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 716540017989 multiple promoter invertase; Provisional; Region: mpi; PRK13413 716540017990 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 716540017991 catalytic residues [active] 716540017992 catalytic nucleophile [active] 716540017993 Presynaptic Site I dimer interface [polypeptide binding]; other site 716540017994 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 716540017995 Synaptic Flat tetramer interface [polypeptide binding]; other site 716540017996 Synaptic Site I dimer interface [polypeptide binding]; other site 716540017997 DNA binding site [nucleotide binding] 716540017998 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 716540017999 DNA-binding interface [nucleotide binding]; DNA binding site 716540018000 superfamily hit to SSF53041, Resolvase-like, score 1.4e-37 716540018001 HMMPfam hit to PF00239, Resolvase, N terminal domain, score 9.6e-66 716540018002 PS00397 Site-specific recombinases active site. 716540018003 PS00398 Site-specific recombinases signature 2. 716540018004 HMMPfam hit to PF02796, Helix-turn-helix domain of resolvase, score 1.3e-12 716540018005 superfamily hit to SSF46689, Homeodomain-like, score 7.8e-08 716540018006 Predicted helix-turn-helix motif with score 1161.000, SD 3.14 at aa 168-189, sequence MSVSAVAREFKTTRQTILRVRA 716540018007 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716540018008 S-adenosylmethionine binding site [chemical binding]; other site 716540018009 superfamily hit to SSF53335, S-adenosyl-L-methionine-dependent methyltransferases, score 1.7e-13 716540018010 HMMPfam hit to PF08241, Methyltransferase domain, score 4.2e-08 716540018011 HMMPfam hit to PF08242, Methyltransferase domain, score 3.4e-19 716540018012 choline transport protein BetT; Provisional; Region: PRK09928 716540018013 HMMPfam hit to PF02028, BCCT family transporter, score 8.7e-299 716540018014 HMMTigr hit to TIGR00842, bcct: choline/carnitine/betaine transport, score 3.1e-258 716540018015 12 probable transmembrane helices predicted for EAM_P133 by TMHMM2.0 at aa 19-41, 56-75, 95-117, 145-167, 196-218, 233-255, 267-289, 321-340, 352-371, 402-424, 454-476 and 480-502 716540018016 PS01303 BCCT family of transporters signature. 716540018017 superfamily hit to SSF90123, Multidrug resistance ABC transporter MsbA, N-terminal domain, score 0.014 716540018018 hypothetical protein; Provisional; Region: PRK09956 716540018019 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 716540018020 HMMPfam hit to PF04754, Putative transposase, YhgA-like, score 4.9e-221 716540018021 HMMTigr hit to TIGR01784, T_den_put_tspse: conserved hypothetic, score 5.8e-93 716540018022 superfamily hit to SSF56634, Heme-linked catalases, score 5.1e-08 716540018023 methionine sulfoxide reductase A; Provisional; Region: PRK14054 716540018024 superfamily hit to SSF55068, Peptide methionine sulfoxide reductase, score 2.6e-61 716540018025 HMMPfam hit to PF01625, Peptide methionine sulfoxide reductase, score 2.2e-74 716540018026 HMMTigr hit to TIGR00401, msrA: methionine-S-sulfoxide reductase, score 6e-70 716540018027 superfamily hit to SSF52540, P-loop containing nucleoside triphosphate hydrolases, score 7e-21 716540018028 PS00017 ATP/GTP-binding site motif A (P-loop). 716540018029 origin 0f replication 716540018030 AT-rich region; part of origin of replication 716540018031 1 probable transmembrane helix predicted for EAM_P142 by TMHMM2.0 at aa 15-34 716540018032 replication protein; Provisional; Region: PRK13702 716540018033 superfamily hit to SSF47598, Met repressor-like, score 0.0016 716540018034 superfamily hit to SSF47598, Met repressor-like, score 0.00026 716540018035 Predicted helix-turn-helix motif with score 1229.000, SD 3.37 at aa 70-91, sequence LSRYDVAEIIGLGGITVSNTKA 716540018036 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 716540018037 active site 716540018038 DNA binding site [nucleotide binding] 716540018039 Int/Topo IB signature motif; other site 716540018040 superfamily hit to SSF56349, DNA breaking-rejoining enzymes, score 2.2e-23 716540018041 HMMPfam hit to PF00589, Phage integrase family, score 1e-15 716540018042 ParA-like protein; Provisional; Region: PHA02518 716540018043 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 716540018044 P-loop; other site 716540018045 Magnesium ion binding site [ion binding]; other site 716540018046 superfamily hit to SSF52540, P-loop containing nucleoside triphosphate hydrolases, score 5e-34 716540018047 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 716540018048 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 716540018049 active site 716540018050 DNA binding site [nucleotide binding] 716540018051 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 716540018052 superfamily hit to SSF56672, DNA/RNA polymerases, score 2.8e-97 716540018053 HMMPfam hit to PF00817, impB/mucB/samB family, score 6.3e-151 716540018054 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 716540018055 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 716540018056 Catalytic site [active] 716540018057 superfamily hit to SSF51306, LexA/Signal peptidase, score 2e-25 716540018058 HMMPfam hit to PF00717, Peptidase S24-like, score 2.4e-17 716540018059 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 716540018060 Mg binding site [ion binding]; other site 716540018061 nucleotide binding site [chemical binding]; other site 716540018062 putative protofilament interface [polypeptide binding]; other site 716540018063 superfamily hit to SSF53067, Actin-like ATPase domain, score 2e-43 716540018064 HMMPfam hit to PF06406, StbA protein, score 1.5e-165 716540018065 superfamily hit to SSF53067, Actin-like ATPase domain, score 1e-14 716540018066 Plasmid stability protein; Region: Plasmid_stab_B; pfam10784 716540018067 Protein of unknown function (DUF1281); Region: DUF1281; pfam06924 716540018068 HMMPfam hit to PF06924, Protein of unknown function (DUF1281), score 5.2e-23 716540018069 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540018070 putative methylase; Provisional; Region: PRK13699 716540018071 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 716540018072 superfamily hit to SSF53335, S-adenosyl-L-methionine-dependent methyltransferases, score 4.8e-36 716540018073 HMMPfam hit to PF01555, DNA methylase, score 5e-50 716540018074 PS00092 N-6 Adenine-specific DNA methylases signature. 716540018075 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 716540018076 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 716540018077 Antirestriction protein; Region: Antirestrict; pfam03230 716540018078 HMMPfam hit to PF03230, Antirestriction protein, score 2.7e-20 716540018079 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 716540018080 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 716540018081 dimer interface [polypeptide binding]; other site 716540018082 ssDNA binding site [nucleotide binding]; other site 716540018083 tetramer (dimer of dimers) interface [polypeptide binding]; other site 716540018084 superfamily hit to SSF50249, Nucleic acid-binding proteins, score 1.1e-46 716540018085 HMMPfam hit to PF00436, Single-strand binding protein family, score 1.6e-32 716540018086 PS00736 Single-strand binding protein family signature 2. 716540018087 PS00017 ATP/GTP-binding site motif A (P-loop). 716540018088 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 716540018089 ParB-like nuclease domain; Region: ParBc; pfam02195 716540018090 HMMPfam hit to PF02195, ParB-like nuclease domain, score 2.7e-16 716540018091 superfamily hit to SSF88659, Sigma3 and sigma4 domains of RNA polymerase sigma factors, score 0.0017 716540018092 PS00017 ATP/GTP-binding site motif A (P-loop). 716540018093 Predicted helix-turn-helix motif with score 1434.000, SD 4.07 at aa 155-176, sequence KTPAQIADLLGYSARHVQRMLK 716540018094 PsiA protein; Region: PsiA; cl11646 716540018095 superfamily hit to SSF89447, Kis/PemI addiction antidote, score 1.2e-06 716540018096 PemK-like protein; Region: PemK; pfam02452 716540018097 superfamily hit to SSF50118, Cell growth inhibitor_plasmid maintainance toxic component, score 4.2e-21 716540018098 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 716540018099 HMMPfam hit to PF06006, Bacterial protein of unknown function (DUF90, score 4.1e-22 716540018100 PS00430 TonB-dependent receptor proteins signature 1. 716540018101 conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877 716540018102 superfamily hit to SSF47598, Met repressor-like, score 0.02 716540018103 HMMPfam hit to PF01402, Ribbon-helix-helix protein, copG family, score 0.00016 716540018104 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 716540018105 HMMPfam hit to PF03432, Relaxase/Mobilisation nuclease domain, score 1.6e-32 716540018106 superfamily hit to SSF46894, C-terminal effector domain of the bipartite response regulators, score 2.9e-05 716540018107 Predicted helix-turn-helix motif with score 1077.000, SD 2.86 at aa 34-55, sequence ANYREIGDLRGVSSETIKKSLE 716540018108 superfamily hit to SSF46894, C-terminal effector domain of the bipartite response regulators, score 0.0055 716540018109 TraY domain; Region: TraY; pfam05509 716540018110 superfamily hit to SSF47598, Met repressor-like, score 0.00069 716540018111 PS00190 Cytochrome c family heme-binding site signature. 716540018112 Signal peptide predicted for EAM_P20048 by SignalP 2.0 HMM (Signal peptide probability 0.979) with cleavage site probability 0.544 between residues 27 and 28 716540018113 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540018114 PS00697 ATP-dependent DNA ligase AMP-binding site. 716540018115 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 716540018116 Signal peptide predicted for EAM_P20049 by SignalP 2.0 HMM (Signal peptide probability 0.947) with cleavage site probability 0.739 between residues 21 and 22 716540018117 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540018118 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 716540018119 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 716540018120 Signal peptide predicted for EAM_P20050 by SignalP 2.0 HMM (Signal peptide probability 0.931) with cleavage site probability 0.612 between residues 18 and 19 716540018121 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540018122 HMMPfam hit to PF07655, Secretin N-terminal domain, score 0.00015 716540018123 Pilin accessory protein (PilO); Region: PAP_PilO; pfam06864 716540018124 Signal peptide predicted for EAM_P20052 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 21 and 22 716540018125 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540018126 Type II/IV secretion system protein; Region: T2SE; pfam00437 716540018127 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 716540018128 Walker A motif; other site 716540018129 ATP binding site [chemical binding]; other site 716540018130 Walker B motif; other site 716540018131 HMMPfam hit to PF00437, Type II/IV secretion system protein, score 4e-14 716540018132 superfamily hit to SSF52540, P-loop containing nucleoside triphosphate hydrolases, score 1.2e-17 716540018133 PS00017 ATP/GTP-binding site motif A (P-loop). 716540018134 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 716540018135 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 716540018136 3 probable transmembrane helices predicted for EAM_P20054 by TMHMM2.0 at aa 128-150, 175-194 and 327-349 716540018137 HMMPfam hit to PF00482, Bacterial type II secretion system protein F, score 2e-08 716540018138 PilS N terminal; Region: PilS; pfam08805 716540018139 Signal peptide predicted for EAM_P20055 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.742 between residues 31 and 32 716540018140 1 probable transmembrane helix predicted for EAM_P20055 by TMHMM2.0 at aa 15-37 716540018141 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 716540018142 Walker A motif; other site 716540018143 ATP binding site [chemical binding]; other site 716540018144 Walker B motif; other site 716540018145 superfamily hit to SSF52540, P-loop containing nucleoside triphosphate hydrolases, score 1.5e-13 716540018146 PS00017 ATP/GTP-binding site motif A (P-loop). 716540018147 Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917 716540018148 Signal peptide predicted for EAM_P20057 by SignalP 2.0 HMM (Signal peptide probability 0.939) with cleavage site probability 0.939 between residues 36 and 37 716540018149 HMMPfam hit to PF04917, Bacterial shufflon protein, N-terminal con, score 3.1e-15 716540018150 1 probable transmembrane helix predicted for EAM_P20057 by TMHMM2.0 at aa 13-35 716540018151 superfamily hit to SSF63848, Cell-division inhibitor MinC, C-terminal domain, score 0.0012 716540018152 Acyltransferase family; Region: Acyl_transf_3; pfam01757 716540018153 OpgC protein; Region: OpgC_C; cl17858 716540018154 HMMPfam hit to PF01757, Acyltransferase family, score 7.5e-23 716540018155 9 probable transmembrane helices predicted for EAM_P20058 by TMHMM2.0 at aa 9-27, 42-64, 85-107, 138-160, 165-187, 202-224, 231-253, 257-279 and 319-341 716540018156 PilM; Region: PilM; pfam07419 716540018157 Signal peptide predicted for EAM_P20059 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.355 between residues 23 and 24 716540018158 1 probable transmembrane helix predicted for EAM_P20059 by TMHMM2.0 at aa 5-22 716540018159 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540018160 Signal peptide predicted for EAM_P20060 by SignalP 2.0 HMM (Signal peptide probability 0.906) with cleavage site probability 0.265 between residues 35 and 36 716540018161 6 probable transmembrane helices predicted for EAM_P20060 by TMHMM2.0 at aa 4-23, 44-66, 81-103, 115-137, 152-174 and 181-203 716540018162 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 716540018163 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 716540018164 N-acetyl-D-glucosamine binding site [chemical binding]; other site 716540018165 catalytic residue [active] 716540018166 superfamily hit to SSF53955, Lysozyme-like, score 8.8e-27 716540018167 Signal peptide predicted for EAM_P20061 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.987 between residues 19 and 20 716540018168 HMMPfam hit to PF01464, Transglycosylase SLT domain, score 1.8e-27 716540018169 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 716540018170 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 716540018171 N-acetyl-D-glucosamine binding site [chemical binding]; other site 716540018172 catalytic residue [active] 716540018173 superfamily hit to SSF53955, Lysozyme-like, score 1.7e-28 716540018174 Signal peptide predicted for EAM_P20062 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.894 between residues 26 and 27 716540018175 HMMPfam hit to PF01464, Transglycosylase SLT domain, score 3.2e-38 716540018176 Signal peptide predicted for EAM_P20063 by SignalP 2.0 HMM (Signal peptide probability 0.969) with cleavage site probability 0.447 between residues 28 and 29 716540018177 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540018178 Signal peptide predicted for EAM_P20064 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.428 between residues 25 and 26 716540018179 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540018180 plasmid transfer ATPase TraJ; Region: plasmid_TraJ; TIGR02525 716540018181 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 716540018182 Walker A motif; other site 716540018183 ATP binding site [chemical binding]; other site 716540018184 Walker B motif; other site 716540018185 HMMPfam hit to PF00437, Type II/IV secretion system protein, score 1.9e-08 716540018186 superfamily hit to SSF52540, P-loop containing nucleoside triphosphate hydrolases, score 1.5e-16 716540018187 PS00017 ATP/GTP-binding site motif A (P-loop). 716540018188 2 probable transmembrane helices predicted for EAM_P20066 by TMHMM2.0 at aa 21-40 and 45-67 716540018189 PS00017 ATP/GTP-binding site motif A (P-loop). 716540018190 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 716540018191 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 716540018192 DNA-binding interface [nucleotide binding]; DNA binding site 716540018193 superfamily hit to SSF56731, DNA primase core, score 7.7e-12 716540018194 superfamily hit to SSF46689, Homeodomain-like, score 4.5e-06 716540018195 HMMPfam hit to PF02796, Helix-turn-helix domain of resolvase, score 4.9e-05 716540018196 Predicted helix-turn-helix motif with score 1753.000, SD 5.16 at aa 481-502, sequence MKAGQIAKELGIGQTSVYRILK 716540018197 Signal peptide predicted for EAM_P20068 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.594 between residues 30 and 31 716540018198 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 716540018199 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 716540018200 Protein of unknown function (DUF3625); Region: DUF3625; pfam12293 716540018201 Signal peptide predicted for EAM_P20070 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.942 between residues 21 and 22 716540018202 1 probable transmembrane helix predicted for EAM_P20071 by TMHMM2.0 at aa 12-34 716540018203 Predicted coiled-coil protein (DUF2205); Region: DUF2205; pfam10224 716540018204 1 probable transmembrane helix predicted for EAM_P20072 by TMHMM2.0 at aa 41-60 716540018205 3 probable transmembrane helices predicted for EAM_P20073 by TMHMM2.0 at aa 15-37, 57-79 and 107-129 716540018206 Signal peptide predicted for EAM_P20074 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.996 between residues 41 and 42 716540018207 3 probable transmembrane helices predicted for EAM_P20074 by TMHMM2.0 at aa 24-43, 63-82 and 94-113 716540018208 superfamily hit to SSF57716, Glucocorticoid receptor-like (DNA-binding domain), score 0.0038 716540018209 AAA-like domain; Region: AAA_10; pfam12846 716540018210 superfamily hit to SSF52540, P-loop containing nucleoside triphosphate hydrolases, score 0.0022 716540018211 PS00017 ATP/GTP-binding site motif A (P-loop). 716540018212 Signal peptide predicted for EAM_P20077 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 28 and 29 716540018213 1 probable transmembrane helix predicted for EAM_P20077 by TMHMM2.0 at aa 13-30 716540018214 2 probable transmembrane helices predicted for EAM_P20079 by TMHMM2.0 at aa 95-117 and 127-149 716540018215 PS00962 Ribosomal protein S2 signature 1. 716540018216 1 probable transmembrane helix predicted for EAM_P20080 by TMHMM2.0 at aa 99-121 716540018217 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 716540018218 Signal peptide predicted for EAM_P20082 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 22 and 23 716540018219 7 probable transmembrane helices predicted for EAM_P20082 by TMHMM2.0 at aa 65-87, 108-130, 509-531, 538-560, 588-610, 623-642 and 652-674 716540018220 superfamily hit to SSF81333, F1F0 ATP synthase subunit C, score 0.0091 716540018221 Signal peptide predicted for EAM_P20083 by SignalP 2.0 HMM (Signal peptide probability 0.621) with cleavage site probability 0.481 between residues 34 and 35 716540018222 2 probable transmembrane helices predicted for EAM_P20083 by TMHMM2.0 at aa 21-43 and 58-76 716540018223 2 probable transmembrane helices predicted for EAM_P20084 by TMHMM2.0 at aa 15-32 and 89-108 716540018224 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 716540018225 1 probable transmembrane helix predicted for EAM_P20085 by TMHMM2.0 at aa 106-128 716540018226 superfamily hit to SSF52833, Thioredoxin-like, score 6.2e-07 716540018227 Predicted helix-turn-helix motif with score 1237.000, SD 3.40 at aa 202-223, sequence RTLYVFADPLCVNCQRMERHFE 716540018228 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 716540018229 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 716540018230 Walker A motif; other site 716540018231 ATP binding site [chemical binding]; other site 716540018232 Walker B motif; other site 716540018233 1 probable transmembrane helix predicted for EAM_P20086 by TMHMM2.0 at aa 41-63 716540018234 superfamily hit to SSF52540, P-loop containing nucleoside triphosphate hydrolases, score 1.4e-05 716540018235 PS00017 ATP/GTP-binding site motif A (P-loop). 716540018236 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 716540018237 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 716540018238 PLD-like domain; Region: PLDc_2; pfam13091 716540018239 putative active site [active] 716540018240 catalytic site [active] 716540018241 superfamily hit to SSF56024, Phospholipase D/nuclease, score 1.9e-34 716540018242 Signal peptide predicted for EAM_P20088 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.518 between residues 20 and 21 716540018243 1 probable transmembrane helix predicted for EAM_P20088 by TMHMM2.0 at aa 5-27