-- dump date 20140619_074107 -- class Genbank::misc_feature -- table misc_feature_note -- id note 226185000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 226185000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 226185000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226185000004 Walker A motif; other site 226185000005 ATP binding site [chemical binding]; other site 226185000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 226185000007 Walker B motif; other site 226185000008 arginine finger; other site 226185000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 226185000010 DnaA box-binding interface [nucleotide binding]; other site 226185000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 226185000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 226185000013 putative DNA binding surface [nucleotide binding]; other site 226185000014 dimer interface [polypeptide binding]; other site 226185000015 beta-clamp/clamp loader binding surface; other site 226185000016 beta-clamp/translesion DNA polymerase binding surface; other site 226185000017 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 226185000018 recombination protein F; Reviewed; Region: recF; PRK00064 226185000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 226185000020 Walker A/P-loop; other site 226185000021 ATP binding site [chemical binding]; other site 226185000022 Q-loop/lid; other site 226185000023 ABC transporter signature motif; other site 226185000024 Walker B; other site 226185000025 D-loop; other site 226185000026 H-loop/switch region; other site 226185000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 226185000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226185000029 ATP binding site [chemical binding]; other site 226185000030 Mg2+ binding site [ion binding]; other site 226185000031 G-X-G motif; other site 226185000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 226185000033 anchoring element; other site 226185000034 dimer interface [polypeptide binding]; other site 226185000035 ATP binding site [chemical binding]; other site 226185000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 226185000037 active site 226185000038 putative metal-binding site [ion binding]; other site 226185000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 226185000040 DNA gyrase subunit A; Validated; Region: PRK05560 226185000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 226185000042 CAP-like domain; other site 226185000043 active site 226185000044 primary dimer interface [polypeptide binding]; other site 226185000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 226185000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 226185000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 226185000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 226185000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 226185000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 226185000051 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 226185000052 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 226185000053 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 226185000054 dimer interface [polypeptide binding]; other site 226185000055 ssDNA binding site [nucleotide binding]; other site 226185000056 tetramer (dimer of dimers) interface [polypeptide binding]; other site 226185000057 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 226185000058 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 226185000059 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 226185000060 DHH family; Region: DHH; pfam01368 226185000061 DHHA1 domain; Region: DHHA1; pfam02272 226185000062 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 226185000063 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 226185000064 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 226185000065 replicative DNA helicase; Provisional; Region: PRK05748 226185000066 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 226185000067 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 226185000068 Walker A motif; other site 226185000069 ATP binding site [chemical binding]; other site 226185000070 Walker B motif; other site 226185000071 DNA binding loops [nucleotide binding] 226185000072 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 226185000073 GDP-binding site [chemical binding]; other site 226185000074 ACT binding site; other site 226185000075 IMP binding site; other site 226185000076 EDD domain protein, DegV family; Region: DegV; TIGR00762 226185000077 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 226185000078 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 226185000079 ABC transporter; Region: ABC_tran_2; pfam12848 226185000080 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 226185000081 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 226185000082 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 226185000083 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226185000084 Walker A motif; other site 226185000085 ATP binding site [chemical binding]; other site 226185000086 Walker B motif; other site 226185000087 arginine finger; other site 226185000088 Transcriptional antiterminator [Transcription]; Region: COG3933 226185000089 PRD domain; Region: PRD; pfam00874 226185000090 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 226185000091 active pocket/dimerization site; other site 226185000092 active site 226185000093 phosphorylation site [posttranslational modification] 226185000094 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cd00133 226185000095 active site 226185000096 P-loop; other site 226185000097 phosphorylation site [posttranslational modification] 226185000098 PRD domain; Region: PRD; pfam00874 226185000099 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 226185000100 active site 226185000101 phosphorylation site [posttranslational modification] 226185000102 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 226185000103 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 226185000104 active pocket/dimerization site; other site 226185000105 active site 226185000106 phosphorylation site [posttranslational modification] 226185000107 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 226185000108 active site 226185000109 phosphorylation site [posttranslational modification] 226185000110 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 226185000111 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 226185000112 Domain of unknown function (DUF956); Region: DUF956; pfam06115 226185000113 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 226185000114 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 226185000115 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 226185000116 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 226185000117 putative active site [active] 226185000118 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 226185000119 PTS system, maltose and glucose-specific IIBC component; Region: PTS-IIBC-malX; TIGR02004 226185000120 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 226185000121 active site turn [active] 226185000122 phosphorylation site [posttranslational modification] 226185000123 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 226185000124 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226185000125 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226185000126 homodimer interface [polypeptide binding]; other site 226185000127 catalytic residue [active] 226185000128 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 226185000129 homotrimer interaction site [polypeptide binding]; other site 226185000130 putative active site [active] 226185000131 Predicted integral membrane protein [Function unknown]; Region: COG0392 226185000132 Uncharacterized conserved protein [Function unknown]; Region: COG2898 226185000133 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 226185000134 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 226185000135 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 226185000136 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 226185000137 dimer interface [polypeptide binding]; other site 226185000138 Predicted transcriptional regulator [Transcription]; Region: COG2378 226185000139 HTH domain; Region: HTH_11; pfam08279 226185000140 WYL domain; Region: WYL; pfam13280 226185000141 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 226185000142 putative catalytic cysteine [active] 226185000143 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 226185000144 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 226185000145 nucleotide binding site [chemical binding]; other site 226185000146 homotetrameric interface [polypeptide binding]; other site 226185000147 putative phosphate binding site [ion binding]; other site 226185000148 putative allosteric binding site; other site 226185000149 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 226185000150 trimer interface [polypeptide binding]; other site 226185000151 active site 226185000152 DNA repair protein RadA; Provisional; Region: PRK11823 226185000153 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 226185000154 Walker A motif/ATP binding site; other site 226185000155 ATP binding site [chemical binding]; other site 226185000156 Walker B motif; other site 226185000157 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 226185000158 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 226185000159 Protein of unknown function (DUF421); Region: DUF421; cl00990 226185000160 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 226185000161 putative active site [active] 226185000162 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 226185000163 homotrimer interaction site [polypeptide binding]; other site 226185000164 zinc binding site [ion binding]; other site 226185000165 CDP-binding sites; other site 226185000166 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 226185000167 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 226185000168 active site 226185000169 HIGH motif; other site 226185000170 KMSKS motif; other site 226185000171 serine O-acetyltransferase; Region: cysE; TIGR01172 226185000172 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 226185000173 trimer interface [polypeptide binding]; other site 226185000174 active site 226185000175 substrate binding site [chemical binding]; other site 226185000176 CoA binding site [chemical binding]; other site 226185000177 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 226185000178 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 226185000179 active site 226185000180 HIGH motif; other site 226185000181 KMSKS motif; other site 226185000182 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 226185000183 tRNA binding surface [nucleotide binding]; other site 226185000184 anticodon binding site; other site 226185000185 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 226185000186 active site 226185000187 metal binding site [ion binding]; metal-binding site 226185000188 dimerization interface [polypeptide binding]; other site 226185000189 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 226185000190 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 226185000191 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 226185000192 YacP-like NYN domain; Region: NYN_YacP; pfam05991 226185000193 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 226185000194 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226185000195 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 226185000196 DNA binding residues [nucleotide binding] 226185000197 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 226185000198 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 226185000199 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 226185000200 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 226185000201 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 226185000202 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 226185000203 active site 226185000204 catalytic site [active] 226185000205 substrate binding site [chemical binding]; other site 226185000206 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 226185000207 Dimer interface [polypeptide binding]; other site 226185000208 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 226185000209 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 226185000210 metal binding site [ion binding]; metal-binding site 226185000211 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 226185000212 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 226185000213 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 226185000214 ABC-ATPase subunit interface; other site 226185000215 dimer interface [polypeptide binding]; other site 226185000216 putative PBP binding regions; other site 226185000217 pur operon repressor; Provisional; Region: PRK09213 226185000218 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 226185000219 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 226185000220 active site 226185000221 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 226185000222 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 226185000223 Substrate binding site; other site 226185000224 Mg++ binding site; other site 226185000225 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 226185000226 active site 226185000227 substrate binding site [chemical binding]; other site 226185000228 CoA binding site [chemical binding]; other site 226185000229 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419 226185000230 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 226185000231 active site 226185000232 metal binding site [ion binding]; metal-binding site 226185000233 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 226185000234 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 226185000235 active site 226185000236 metal binding site [ion binding]; metal-binding site 226185000237 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 226185000238 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 226185000239 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 226185000240 peptide binding site [polypeptide binding]; other site 226185000241 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 226185000242 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 226185000243 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 226185000244 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 226185000245 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 226185000246 RuvA N terminal domain; Region: RuvA_N; pfam01330 226185000247 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 226185000248 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 226185000249 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 226185000250 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226185000251 Walker A motif; other site 226185000252 ATP binding site [chemical binding]; other site 226185000253 Walker B motif; other site 226185000254 arginine finger; other site 226185000255 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 226185000256 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 226185000257 putative active site cavity [active] 226185000258 Trehalase; Region: Trehalase; cl17346 226185000259 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226185000260 non-specific DNA binding site [nucleotide binding]; other site 226185000261 salt bridge; other site 226185000262 sequence-specific DNA binding site [nucleotide binding]; other site 226185000263 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 226185000264 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 226185000265 ligand binding site [chemical binding]; other site 226185000266 flexible hinge region; other site 226185000267 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 226185000268 oxidoreductase; Provisional; Region: PRK07985 226185000269 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226185000270 NAD(P) binding site [chemical binding]; other site 226185000271 active site 226185000272 Small integral membrane protein (DUF2273); Region: DUF2273; cl11575 226185000273 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 226185000274 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 226185000275 Predicted membrane protein [Function unknown]; Region: COG2261 226185000276 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226185000277 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226185000278 putative substrate translocation pore; other site 226185000279 Mga helix-turn-helix domain; Region: Mga; pfam05043 226185000280 Mga helix-turn-helix domain; Region: Mga; pfam05043 226185000281 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 226185000282 Collagen binding domain; Region: Collagen_bind; pfam05737 226185000283 Collagen binding domain; Region: Collagen_bind; pfam05737 226185000284 Collagen binding domain; Region: Collagen_bind; pfam05737 226185000285 Collagen binding domain; Region: Collagen_bind; pfam05737 226185000286 Collagen binding domain; Region: Collagen_bind; pfam05737 226185000287 Cna protein B-type domain; Region: Cna_B; pfam05738 226185000288 Cna protein B-type domain; Region: Cna_B; pfam05738 226185000289 Cna protein B-type domain; Region: Cna_B; pfam05738 226185000290 Cna protein B-type domain; Region: Cna_B; pfam05738 226185000291 Cna protein B-type domain; Region: Cna_B; pfam05738 226185000292 Cna protein B-type domain; Region: Cna_B; pfam05738 226185000293 Cna protein B-type domain; Region: Cna_B; pfam05738 226185000294 Cna protein B-type domain; Region: Cna_B; pfam05738 226185000295 Cna protein B-type domain; Region: Cna_B; pfam05738 226185000296 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 226185000297 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 226185000298 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 226185000299 Mga helix-turn-helix domain; Region: Mga; pfam05043 226185000300 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 226185000301 Rib/alpha-like repeat; Region: Rib; cl07159 226185000302 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 226185000303 superantigen-like protein; Reviewed; Region: PRK13042 226185000304 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 226185000305 YheO-like PAS domain; Region: PAS_6; pfam08348 226185000306 HTH domain; Region: HTH_22; pfam13309 226185000307 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 226185000308 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 226185000309 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 226185000310 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 226185000311 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 226185000312 seryl-tRNA synthetase; Provisional; Region: PRK05431 226185000313 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 226185000314 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 226185000315 dimer interface [polypeptide binding]; other site 226185000316 active site 226185000317 motif 1; other site 226185000318 motif 2; other site 226185000319 motif 3; other site 226185000320 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 226185000321 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 226185000322 Arginine repressor [Transcription]; Region: ArgR; COG1438 226185000323 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 226185000324 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 226185000325 Arginine repressor [Transcription]; Region: ArgR; COG1438 226185000326 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 226185000327 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 226185000328 arginine deiminase; Provisional; Region: PRK01388 226185000329 ornithine carbamoyltransferase; Validated; Region: PRK02102 226185000330 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 226185000331 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 226185000332 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 226185000333 putative substrate binding site [chemical binding]; other site 226185000334 nucleotide binding site [chemical binding]; other site 226185000335 nucleotide binding site [chemical binding]; other site 226185000336 homodimer interface [polypeptide binding]; other site 226185000337 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 226185000338 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 226185000339 ligand binding site [chemical binding]; other site 226185000340 flexible hinge region; other site 226185000341 putative switch regulator; other site 226185000342 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 226185000343 non-specific DNA interactions [nucleotide binding]; other site 226185000344 DNA binding site [nucleotide binding] 226185000345 sequence specific DNA binding site [nucleotide binding]; other site 226185000346 putative cAMP binding site [chemical binding]; other site 226185000347 Predicted membrane protein [Function unknown]; Region: COG1288 226185000348 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 226185000349 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 226185000350 potential catalytic triad [active] 226185000351 conserved cys residue [active] 226185000352 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226185000353 dimerization interface [polypeptide binding]; other site 226185000354 putative DNA binding site [nucleotide binding]; other site 226185000355 putative Zn2+ binding site [ion binding]; other site 226185000356 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 226185000357 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 226185000358 putative NAD(P) binding site [chemical binding]; other site 226185000359 ParB-like nuclease domain; Region: ParBc; pfam02195 226185000360 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 226185000361 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 226185000362 ParB-like nuclease domain; Region: ParBc; pfam02195 226185000363 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 226185000364 active site 226185000365 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 226185000366 active site 226185000367 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 226185000368 homotrimer interaction site [polypeptide binding]; other site 226185000369 putative active site [active] 226185000370 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 226185000371 homotrimer interaction site [polypeptide binding]; other site 226185000372 putative active site [active] 226185000373 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 226185000374 homotrimer interaction site [polypeptide binding]; other site 226185000375 putative active site [active] 226185000376 MepB protein; Region: MepB; pfam08877 226185000377 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 226185000378 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226185000379 DNA-binding site [nucleotide binding]; DNA binding site 226185000380 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226185000381 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226185000382 homodimer interface [polypeptide binding]; other site 226185000383 catalytic residue [active] 226185000384 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 226185000385 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; cl19124 226185000386 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 226185000387 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 226185000388 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 226185000389 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 226185000390 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 226185000391 Clostridial hydrophobic W; Region: ChW; pfam07538 226185000392 Clostridial hydrophobic W; Region: ChW; pfam07538 226185000393 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 226185000394 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 226185000395 Clostridial hydrophobic W; Region: ChW; pfam07538 226185000396 Clostridial hydrophobic W; Region: ChW; pfam07538 226185000397 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 226185000398 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 226185000399 Clostridial hydrophobic W; Region: ChW; pfam07538 226185000400 Clostridial hydrophobic W; Region: ChW; pfam07538 226185000401 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 226185000402 putative active site [active] 226185000403 Transposase, Mutator family; Region: Transposase_mut; pfam00872 226185000404 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 226185000405 Restriction endonuclease; Region: Mrr_cat; pfam04471 226185000406 Domain of unknown function (DUF955); Region: DUF955; cl01076 226185000407 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226185000408 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226185000409 non-specific DNA binding site [nucleotide binding]; other site 226185000410 salt bridge; other site 226185000411 sequence-specific DNA binding site [nucleotide binding]; other site 226185000412 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 226185000413 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 226185000414 active site 226185000415 NTP binding site [chemical binding]; other site 226185000416 metal binding triad [ion binding]; metal-binding site 226185000417 antibiotic binding site [chemical binding]; other site 226185000418 Protein of unknown function DUF86; Region: DUF86; cl01031 226185000419 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 226185000420 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226185000421 non-specific DNA binding site [nucleotide binding]; other site 226185000422 salt bridge; other site 226185000423 sequence-specific DNA binding site [nucleotide binding]; other site 226185000424 Replication initiation factor; Region: Rep_trans; pfam02486 226185000425 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 226185000426 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 226185000427 SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133 226185000428 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 226185000429 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 226185000430 Glucan-binding protein C; Region: GbpC; pfam08363 226185000431 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 226185000432 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 226185000433 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 226185000434 DHHW protein; Region: DHHW; pfam14286 226185000435 tegument protein; Provisional; Region: PHA03373 226185000436 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 226185000437 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 226185000438 TcpE family; Region: TcpE; pfam12648 226185000439 AAA-like domain; Region: AAA_10; pfam12846 226185000440 Mpp10 protein; Region: Mpp10; pfam04006 226185000441 CHAP domain; Region: CHAP; cl17642 226185000442 Domain of unknown function (DUF3173); Region: DUF3173; pfam11372 226185000443 AP2-like DNA-binding integrase domain; Region: Integrase_AP2; pfam14657 226185000444 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 226185000445 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 226185000446 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 226185000447 Int/Topo IB signature motif; other site 226185000448 GMP synthase; Reviewed; Region: guaA; PRK00074 226185000449 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 226185000450 AMP/PPi binding site [chemical binding]; other site 226185000451 candidate oxyanion hole; other site 226185000452 catalytic triad [active] 226185000453 potential glutamine specificity residues [chemical binding]; other site 226185000454 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 226185000455 ATP Binding subdomain [chemical binding]; other site 226185000456 Ligand Binding sites [chemical binding]; other site 226185000457 Dimerization subdomain; other site 226185000458 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 226185000459 ATP-binding site [chemical binding]; other site 226185000460 CoA-binding site [chemical binding]; other site 226185000461 Mg2+-binding site [ion binding]; other site 226185000462 Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838 226185000463 catalytic triad [active] 226185000464 oxyanion hole [active] 226185000465 active site 226185000466 Methyltransferase domain; Region: Methyltransf_31; pfam13847 226185000467 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226185000468 S-adenosylmethionine binding site [chemical binding]; other site 226185000469 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 226185000470 active site 226185000471 purine riboside binding site [chemical binding]; other site 226185000472 Transcriptional regulators [Transcription]; Region: PurR; COG1609 226185000473 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 226185000474 DNA binding site [nucleotide binding] 226185000475 domain linker motif; other site 226185000476 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 226185000477 dimerization interface [polypeptide binding]; other site 226185000478 ligand binding site [chemical binding]; other site 226185000479 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 226185000480 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 226185000481 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 226185000482 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 226185000483 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 226185000484 intersubunit interface [polypeptide binding]; other site 226185000485 active site 226185000486 catalytic residue [active] 226185000487 Cytidine deaminase [Nucleotide transport and metabolism]; Region: Cdd; COG0295 226185000488 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 226185000489 active site 226185000490 catalytic motif [active] 226185000491 Zn binding site [ion binding]; other site 226185000492 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 226185000493 ligand binding site [chemical binding]; other site 226185000494 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 226185000495 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 226185000496 ligand binding site [chemical binding]; other site 226185000497 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 226185000498 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 226185000499 Walker A/P-loop; other site 226185000500 ATP binding site [chemical binding]; other site 226185000501 Q-loop/lid; other site 226185000502 ABC transporter signature motif; other site 226185000503 Walker B; other site 226185000504 D-loop; other site 226185000505 H-loop/switch region; other site 226185000506 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 226185000507 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 226185000508 TM-ABC transporter signature motif; other site 226185000509 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 226185000510 TM-ABC transporter signature motif; other site 226185000511 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 226185000512 phosphopentomutase; Provisional; Region: PRK05362 226185000513 purine nucleoside phosphorylase; Provisional; Region: PRK08202 226185000514 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 226185000515 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 226185000516 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 226185000517 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 226185000518 putative ligand binding residues [chemical binding]; other site 226185000519 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 226185000520 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 226185000521 Walker A/P-loop; other site 226185000522 ATP binding site [chemical binding]; other site 226185000523 Q-loop/lid; other site 226185000524 ABC transporter signature motif; other site 226185000525 Walker B; other site 226185000526 D-loop; other site 226185000527 H-loop/switch region; other site 226185000528 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 226185000529 ABC-ATPase subunit interface; other site 226185000530 dimer interface [polypeptide binding]; other site 226185000531 putative PBP binding regions; other site 226185000532 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 226185000533 ABC-ATPase subunit interface; other site 226185000534 dimer interface [polypeptide binding]; other site 226185000535 putative PBP binding regions; other site 226185000536 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 226185000537 dimer interface [polypeptide binding]; other site 226185000538 active site 226185000539 metal binding site [ion binding]; metal-binding site 226185000540 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 226185000541 catalytic core [active] 226185000542 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 226185000543 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 226185000544 catalytic residues [active] 226185000545 catalytic nucleophile [active] 226185000546 Presynaptic Site I dimer interface [polypeptide binding]; other site 226185000547 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 226185000548 Synaptic Flat tetramer interface [polypeptide binding]; other site 226185000549 Synaptic Site I dimer interface [polypeptide binding]; other site 226185000550 DNA binding site [nucleotide binding] 226185000551 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 226185000552 tetramer (dimer of dimers) interface [polypeptide binding]; other site 226185000553 active site 226185000554 dimer interface [polypeptide binding]; other site 226185000555 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 226185000556 S17 interaction site [polypeptide binding]; other site 226185000557 S8 interaction site; other site 226185000558 16S rRNA interaction site [nucleotide binding]; other site 226185000559 streptomycin interaction site [chemical binding]; other site 226185000560 23S rRNA interaction site [nucleotide binding]; other site 226185000561 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 226185000562 30S ribosomal protein S7; Validated; Region: PRK05302 226185000563 elongation factor G; Reviewed; Region: PRK00007 226185000564 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 226185000565 G1 box; other site 226185000566 putative GEF interaction site [polypeptide binding]; other site 226185000567 GTP/Mg2+ binding site [chemical binding]; other site 226185000568 Switch I region; other site 226185000569 G2 box; other site 226185000570 G3 box; other site 226185000571 Switch II region; other site 226185000572 G4 box; other site 226185000573 G5 box; other site 226185000574 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 226185000575 Elongation Factor G, domain II; Region: EFG_II; pfam14492 226185000576 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 226185000577 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 226185000578 elongation factor Tu; Reviewed; Region: PRK00049 226185000579 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 226185000580 G1 box; other site 226185000581 GEF interaction site [polypeptide binding]; other site 226185000582 GTP/Mg2+ binding site [chemical binding]; other site 226185000583 Switch I region; other site 226185000584 G2 box; other site 226185000585 G3 box; other site 226185000586 Switch II region; other site 226185000587 G4 box; other site 226185000588 G5 box; other site 226185000589 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 226185000590 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 226185000591 Antibiotic Binding Site [chemical binding]; other site 226185000592 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 226185000593 dimer interface [polypeptide binding]; other site 226185000594 substrate binding site [chemical binding]; other site 226185000595 ATP binding site [chemical binding]; other site 226185000596 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 226185000597 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226185000598 S-adenosylmethionine binding site [chemical binding]; other site 226185000599 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 226185000600 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 226185000601 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 226185000602 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 226185000603 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 226185000604 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 226185000605 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 226185000606 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 226185000607 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 226185000608 putative translocon binding site; other site 226185000609 protein-rRNA interface [nucleotide binding]; other site 226185000610 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 226185000611 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 226185000612 G-X-X-G motif; other site 226185000613 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 226185000614 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 226185000615 23S rRNA interface [nucleotide binding]; other site 226185000616 5S rRNA interface [nucleotide binding]; other site 226185000617 putative antibiotic binding site [chemical binding]; other site 226185000618 L25 interface [polypeptide binding]; other site 226185000619 L27 interface [polypeptide binding]; other site 226185000620 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 226185000621 23S rRNA interface [nucleotide binding]; other site 226185000622 putative translocon interaction site; other site 226185000623 signal recognition particle (SRP54) interaction site; other site 226185000624 L23 interface [polypeptide binding]; other site 226185000625 trigger factor interaction site; other site 226185000626 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 226185000627 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 226185000628 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 226185000629 RNA binding site [nucleotide binding]; other site 226185000630 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 226185000631 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 226185000632 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 226185000633 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 226185000634 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 226185000635 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 226185000636 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 226185000637 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 226185000638 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 226185000639 5S rRNA interface [nucleotide binding]; other site 226185000640 L27 interface [polypeptide binding]; other site 226185000641 23S rRNA interface [nucleotide binding]; other site 226185000642 L5 interface [polypeptide binding]; other site 226185000643 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 226185000644 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 226185000645 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 226185000646 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 226185000647 23S rRNA binding site [nucleotide binding]; other site 226185000648 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 226185000649 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 226185000650 SecY translocase; Region: SecY; pfam00344 226185000651 adenylate kinase; Reviewed; Region: adk; PRK00279 226185000652 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 226185000653 AMP-binding site [chemical binding]; other site 226185000654 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 226185000655 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 226185000656 rRNA binding site [nucleotide binding]; other site 226185000657 predicted 30S ribosome binding site; other site 226185000658 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 226185000659 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 226185000660 30S ribosomal protein S11; Validated; Region: PRK05309 226185000661 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 226185000662 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 226185000663 alphaNTD homodimer interface [polypeptide binding]; other site 226185000664 alphaNTD - beta interaction site [polypeptide binding]; other site 226185000665 alphaNTD - beta' interaction site [polypeptide binding]; other site 226185000666 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 226185000667 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 226185000668 Sodium/glutamate symporter; Region: Glt_symporter; cl19414 226185000669 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 226185000670 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 226185000671 metal binding site [ion binding]; metal-binding site 226185000672 putative dimer interface [polypeptide binding]; other site 226185000673 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 226185000674 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 226185000675 Walker A/P-loop; other site 226185000676 ATP binding site [chemical binding]; other site 226185000677 Q-loop/lid; other site 226185000678 ABC transporter signature motif; other site 226185000679 Walker B; other site 226185000680 D-loop; other site 226185000681 H-loop/switch region; other site 226185000682 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 226185000683 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 226185000684 Walker A/P-loop; other site 226185000685 ATP binding site [chemical binding]; other site 226185000686 Q-loop/lid; other site 226185000687 ABC transporter signature motif; other site 226185000688 Walker B; other site 226185000689 D-loop; other site 226185000690 H-loop/switch region; other site 226185000691 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 226185000692 hypothetical protein; Provisional; Region: PRK00967 226185000693 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 226185000694 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 226185000695 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226185000696 Coenzyme A binding pocket [chemical binding]; other site 226185000697 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 226185000698 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 226185000699 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 226185000700 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 226185000701 Walker A/P-loop; other site 226185000702 ATP binding site [chemical binding]; other site 226185000703 Q-loop/lid; other site 226185000704 ABC transporter signature motif; other site 226185000705 Walker B; other site 226185000706 D-loop; other site 226185000707 H-loop/switch region; other site 226185000708 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 226185000709 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 226185000710 substrate binding pocket [chemical binding]; other site 226185000711 membrane-bound complex binding site; other site 226185000712 hinge residues; other site 226185000713 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 226185000714 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226185000715 dimer interface [polypeptide binding]; other site 226185000716 conserved gate region; other site 226185000717 putative PBP binding loops; other site 226185000718 ABC-ATPase subunit interface; other site 226185000719 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 226185000720 NAD+ binding site [chemical binding]; other site 226185000721 substrate binding site [chemical binding]; other site 226185000722 putative Zn binding site [ion binding]; other site 226185000723 maltose O-acetyltransferase; Provisional; Region: PRK10092 226185000724 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 226185000725 active site 226185000726 substrate binding site [chemical binding]; other site 226185000727 trimer interface [polypeptide binding]; other site 226185000728 CoA binding site [chemical binding]; other site 226185000729 monofunctional chorismate mutase, gram positive-type, clade 2; Region: CM_mono_grmpos; TIGR01805 226185000730 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 226185000731 HTH domain; Region: HTH_11; pfam08279 226185000732 3H domain; Region: 3H; pfam02829 226185000733 E4 protein; Provisional; Region: PHA03420 226185000734 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 226185000735 CHAP domain; Region: CHAP; pfam05257 226185000736 aldehyde dehydrogenase family 2 member; Region: PLN02466 226185000737 Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117 226185000738 NAD(P) binding site [chemical binding]; other site 226185000739 catalytic residues [active] 226185000740 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 226185000741 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 226185000742 tetramer (dimer of dimers) interface [polypeptide binding]; other site 226185000743 NAD binding site [chemical binding]; other site 226185000744 dimer interface [polypeptide binding]; other site 226185000745 substrate binding site [chemical binding]; other site 226185000746 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 226185000747 putative active site [active] 226185000748 catalytic residue [active] 226185000749 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 226185000750 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 226185000751 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226185000752 ATP binding site [chemical binding]; other site 226185000753 putative Mg++ binding site [ion binding]; other site 226185000754 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226185000755 nucleotide binding region [chemical binding]; other site 226185000756 ATP-binding site [chemical binding]; other site 226185000757 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 226185000758 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 226185000759 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 226185000760 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 226185000761 RNA binding surface [nucleotide binding]; other site 226185000762 Septum formation initiator; Region: DivIC; pfam04977 226185000763 hypothetical protein; Provisional; Region: PRK08582 226185000764 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 226185000765 RNA binding site [nucleotide binding]; other site 226185000766 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 226185000767 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 226185000768 Ligand Binding Site [chemical binding]; other site 226185000769 TilS substrate C-terminal domain; Region: TilS_C; smart00977 226185000770 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 226185000771 active site 226185000772 FtsH Extracellular; Region: FtsH_ext; pfam06480 226185000773 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 226185000774 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226185000775 Walker A motif; other site 226185000776 ATP binding site [chemical binding]; other site 226185000777 Walker B motif; other site 226185000778 arginine finger; other site 226185000779 Peptidase family M41; Region: Peptidase_M41; pfam01434 226185000780 Translation initiation factor eIF3 subunit; Region: eIF3_subunit; pfam08597 226185000781 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 226185000782 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 226185000783 dimerization interface [polypeptide binding]; other site 226185000784 domain crossover interface; other site 226185000785 redox-dependent activation switch; other site 226185000786 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 226185000787 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 226185000788 FMN binding site [chemical binding]; other site 226185000789 active site 226185000790 catalytic residues [active] 226185000791 substrate binding site [chemical binding]; other site 226185000792 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 226185000793 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 226185000794 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 226185000795 dimer interface [polypeptide binding]; other site 226185000796 putative anticodon binding site; other site 226185000797 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 226185000798 motif 1; other site 226185000799 active site 226185000800 motif 2; other site 226185000801 motif 3; other site 226185000802 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 226185000803 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 226185000804 active site turn [active] 226185000805 phosphorylation site [posttranslational modification] 226185000806 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 226185000807 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 226185000808 HPr interaction site; other site 226185000809 glycerol kinase (GK) interaction site [polypeptide binding]; other site 226185000810 active site 226185000811 phosphorylation site [posttranslational modification] 226185000812 6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593 226185000813 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 226185000814 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 226185000815 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 226185000816 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 226185000817 catalytic core [active] 226185000818 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 226185000819 Putative lysophospholipase; Region: Hydrolase_4; cl19140 226185000820 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 226185000821 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 226185000822 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226185000823 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226185000824 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 226185000825 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 226185000826 DNA binding site [nucleotide binding] 226185000827 active site 226185000828 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 226185000829 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 226185000830 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 226185000831 Zn2+ binding site [ion binding]; other site 226185000832 Mg2+ binding site [ion binding]; other site 226185000833 Cation efflux family; Region: Cation_efflux; cl00316 226185000834 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 226185000835 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 226185000836 NAD binding site [chemical binding]; other site 226185000837 homotetramer interface [polypeptide binding]; other site 226185000838 homodimer interface [polypeptide binding]; other site 226185000839 substrate binding site [chemical binding]; other site 226185000840 active site 226185000841 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 226185000842 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 226185000843 dimer interface [polypeptide binding]; other site 226185000844 active site 226185000845 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 226185000846 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 226185000847 active site 226185000848 FMN binding site [chemical binding]; other site 226185000849 substrate binding site [chemical binding]; other site 226185000850 catalytic residues [active] 226185000851 homodimer interface [polypeptide binding]; other site 226185000852 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 226185000853 elongation factor P; Validated; Region: PRK00529 226185000854 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 226185000855 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 226185000856 RNA binding site [nucleotide binding]; other site 226185000857 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 226185000858 RNA binding site [nucleotide binding]; other site 226185000859 cysteine synthase; Region: PLN02565 226185000860 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 226185000861 dimer interface [polypeptide binding]; other site 226185000862 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226185000863 catalytic residue [active] 226185000864 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 226185000865 homodimer interface [polypeptide binding]; other site 226185000866 substrate-cofactor binding pocket; other site 226185000867 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226185000868 catalytic residue [active] 226185000869 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 226185000870 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 226185000871 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 226185000872 transcriptional regulator MurR; Provisional; Region: PRK15482 226185000873 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 226185000874 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 226185000875 putative active site [active] 226185000876 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 226185000877 folate binding site [chemical binding]; other site 226185000878 NADP+ binding site [chemical binding]; other site 226185000879 Cation transport protein; Region: TrkH; cl17365 226185000880 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 226185000881 Cation transport protein; Region: TrkH; pfam02386 226185000882 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 226185000883 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 226185000884 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 226185000885 metal-binding site [ion binding] 226185000886 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 226185000887 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 226185000888 metal-binding site [ion binding] 226185000889 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 226185000890 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226185000891 motif II; other site 226185000892 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 226185000893 metal-binding site [ion binding] 226185000894 Protein of unknown function (DUF1648); Region: DUF1648; cl19856 226185000895 Predicted transcriptional regulators [Transcription]; Region: COG1725 226185000896 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226185000897 DNA-binding site [nucleotide binding]; DNA binding site 226185000898 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 226185000899 trimer interface [polypeptide binding]; other site 226185000900 active site 226185000901 G bulge; other site 226185000902 PHAGE01, prophage. 226185000903 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 226185000904 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 226185000905 Int/Topo IB signature motif; other site 226185000906 Ring-infected erythrocyte surface antigen; Provisional; Region: PTZ00341 226185000907 Domain of unknown function (DUF955); Region: DUF955; pfam06114 226185000908 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226185000909 non-specific DNA binding site [nucleotide binding]; other site 226185000910 salt bridge; other site 226185000911 sequence-specific DNA binding site [nucleotide binding]; other site 226185000912 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226185000913 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226185000914 non-specific DNA binding site [nucleotide binding]; other site 226185000915 salt bridge; other site 226185000916 sequence-specific DNA binding site [nucleotide binding]; other site 226185000917 Protein of unknown function (DUF1140); Region: DUF1140; pfam06600 226185000918 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 226185000919 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226185000920 non-specific DNA binding site [nucleotide binding]; other site 226185000921 salt bridge; other site 226185000922 sequence-specific DNA binding site [nucleotide binding]; other site 226185000923 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 226185000924 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 226185000925 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 226185000926 active site 226185000927 DNA binding site [nucleotide binding] 226185000928 catalytic site [active] 226185000929 Snapin/Pallidin; Region: Snapin_Pallidin; pfam14712 226185000930 Virulence-associated protein E; Region: VirE; pfam05272 226185000931 VRR-NUC domain; Region: VRR_NUC; pfam08774 226185000932 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 226185000933 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226185000934 ATP binding site [chemical binding]; other site 226185000935 putative Mg++ binding site [ion binding]; other site 226185000936 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226185000937 nucleotide binding region [chemical binding]; other site 226185000938 ATP-binding site [chemical binding]; other site 226185000939 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 226185000940 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 226185000941 DNA binding residues [nucleotide binding] 226185000942 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 226185000943 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 226185000944 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 226185000945 active site 226185000946 conformational flexibility of ligand binding pocket; other site 226185000947 ADP-ribosylating toxin turn-turn motif; other site 226185000948 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 226185000949 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 226185000950 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 226185000951 Phage-related protein [Function unknown]; Region: COG5412 226185000952 Baculovirus polyhedron envelope protein, PEP, C terminus; Region: Baculo_PEP_C; pfam04513 226185000953 putative minor structural protein; Region: PHA01351 226185000954 Phage tail protein; Region: Sipho_tail; pfam05709 226185000955 Siphovirus ReqiPepy6 Gp37-like protein; Region: Sipho_Gp37; pfam14594 226185000956 Haemolysin XhlA; Region: XhlA; pfam10779 226185000957 Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415 226185000958 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 226185000959 active site 226185000960 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 226185000961 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 226185000962 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 226185000963 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 226185000964 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 226185000965 Zn binding site [ion binding]; other site 226185000966 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 226185000967 Zn binding site [ion binding]; other site 226185000968 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 226185000969 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 226185000970 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 226185000971 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 226185000972 putative active site [active] 226185000973 Chitin binding domain; Region: Chitin_bind_3; pfam03067 226185000974 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 226185000975 Transposase, Mutator family; Region: Transposase_mut; cl19537 226185000976 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 226185000977 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 226185000978 active site 226185000979 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 226185000980 active site 226185000981 Protein of unknown function DUF72; Region: DUF72; pfam01904 226185000982 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545 226185000983 putative nucleotide binding site [chemical binding]; other site 226185000984 putative metal binding site [ion binding]; other site 226185000985 aspartate kinase; Reviewed; Region: PRK09034 226185000986 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 226185000987 putative catalytic residues [active] 226185000988 putative nucleotide binding site [chemical binding]; other site 226185000989 putative aspartate binding site [chemical binding]; other site 226185000990 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 226185000991 allosteric regulatory residue; other site 226185000992 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 226185000993 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 226185000994 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 226185000995 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226185000996 active site 226185000997 motif I; other site 226185000998 motif II; other site 226185000999 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 226185001000 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 226185001001 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 226185001002 catalytic residue [active] 226185001003 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226185001004 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226185001005 active site 226185001006 phosphorylation site [posttranslational modification] 226185001007 intermolecular recognition site; other site 226185001008 dimerization interface [polypeptide binding]; other site 226185001009 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226185001010 DNA binding site [nucleotide binding] 226185001011 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226185001012 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226185001013 dimer interface [polypeptide binding]; other site 226185001014 phosphorylation site [posttranslational modification] 226185001015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226185001016 ATP binding site [chemical binding]; other site 226185001017 Mg2+ binding site [ion binding]; other site 226185001018 G-X-G motif; other site 226185001019 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 226185001020 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 226185001021 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 226185001022 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 226185001023 Fic/DOC family; Region: Fic; cl00960 226185001024 putative addiction module antidote; Region: doc_partner; TIGR02609 226185001025 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 226185001026 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 226185001027 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 226185001028 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 226185001029 membrane protein FdrA; Validated; Region: PRK06091 226185001030 CoA binding domain; Region: CoA_binding; pfam02629 226185001031 CoA-ligase; Region: Ligase_CoA; pfam00549 226185001032 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 226185001033 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 226185001034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226185001035 D-galactonate transporter; Region: 2A0114; TIGR00893 226185001036 putative substrate translocation pore; other site 226185001037 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 226185001038 putative substrate binding site [chemical binding]; other site 226185001039 nucleotide binding site [chemical binding]; other site 226185001040 nucleotide binding site [chemical binding]; other site 226185001041 homodimer interface [polypeptide binding]; other site 226185001042 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 226185001043 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 226185001044 cytosine deaminase; Provisional; Region: PRK05985 226185001045 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 226185001046 active site 226185001047 WxL domain surface cell wall-binding; Region: WxL; pfam13731 226185001048 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 226185001049 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 226185001050 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 226185001051 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 226185001052 substrate binding site [chemical binding]; other site 226185001053 THF binding site; other site 226185001054 zinc-binding site [ion binding]; other site 226185001055 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 226185001056 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 226185001057 Protein of unknown function (DUF969); Region: DUF969; cl01573 226185001058 Protein of unknown function (DUF979); Region: DUF979; pfam06166 226185001059 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 226185001060 putative substrate binding pocket [chemical binding]; other site 226185001061 AC domain interface; other site 226185001062 catalytic triad [active] 226185001063 AB domain interface; other site 226185001064 interchain disulfide; other site 226185001065 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 226185001066 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 226185001067 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 226185001068 Transcriptional regulators [Transcription]; Region: MarR; COG1846 226185001069 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226185001070 putative DNA binding site [nucleotide binding]; other site 226185001071 putative Zn2+ binding site [ion binding]; other site 226185001072 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 226185001073 dimer interface [polypeptide binding]; other site 226185001074 FMN binding site [chemical binding]; other site 226185001075 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226185001076 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 226185001077 active site 226185001078 motif I; other site 226185001079 motif II; other site 226185001080 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 226185001081 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 226185001082 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 226185001083 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 226185001084 active site 226185001085 P-loop; other site 226185001086 phosphorylation site [posttranslational modification] 226185001087 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 226185001088 active site 226185001089 P-loop; other site 226185001090 phosphorylation site [posttranslational modification] 226185001091 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 226185001092 HTH domain; Region: HTH_11; pfam08279 226185001093 PRD domain; Region: PRD; pfam00874 226185001094 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 226185001095 P-loop; other site 226185001096 active site 226185001097 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762 226185001098 active site 226185001099 phosphorylation site [posttranslational modification] 226185001100 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 226185001101 active site 226185001102 phosphorylation site [posttranslational modification] 226185001103 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 226185001104 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 226185001105 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 226185001106 active site 226185001107 P-loop; other site 226185001108 phosphorylation site [posttranslational modification] 226185001109 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 226185001110 active site 226185001111 P-loop; other site 226185001112 phosphorylation site [posttranslational modification] 226185001113 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 226185001114 active site 226185001115 phosphorylation site [posttranslational modification] 226185001116 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 226185001117 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 226185001118 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 226185001119 FAD dependent oxidoreductase; Region: DAO; pfam01266 226185001120 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 226185001121 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226185001122 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 226185001123 NAD(P) binding site [chemical binding]; other site 226185001124 active site 226185001125 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 226185001126 TrbC/VIRB2 family; Region: TrbC; pfam04956 226185001127 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 226185001128 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 226185001129 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226185001130 putative substrate translocation pore; other site 226185001131 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 226185001132 DNA binding residues [nucleotide binding] 226185001133 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 226185001134 putative dimer interface [polypeptide binding]; other site 226185001135 Transcriptional regulator [Transcription]; Region: IclR; COG1414 226185001136 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 226185001137 Bacterial transcriptional regulator; Region: IclR; pfam01614 226185001138 Entner-Doudoroff aldolase; Region: eda; TIGR01182 226185001139 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 226185001140 active site 226185001141 intersubunit interface [polypeptide binding]; other site 226185001142 catalytic residue [active] 226185001143 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 226185001144 substrate binding site [chemical binding]; other site 226185001145 ATP binding site [chemical binding]; other site 226185001146 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 226185001147 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 226185001148 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 226185001149 NADP binding site [chemical binding]; other site 226185001150 homodimer interface [polypeptide binding]; other site 226185001151 active site 226185001152 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 226185001153 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 226185001154 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 226185001155 DctM-like transporters; Region: DctM; pfam06808 226185001156 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 226185001157 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 226185001158 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226185001159 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226185001160 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 226185001161 N- and C-terminal domain interface [polypeptide binding]; other site 226185001162 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 226185001163 active site 226185001164 putative catalytic site [active] 226185001165 metal binding site [ion binding]; metal-binding site 226185001166 ATP binding site [chemical binding]; other site 226185001167 carbohydrate binding site [chemical binding]; other site 226185001168 L-rhamnose isomerase; Provisional; Region: PRK01076 226185001169 rhamnulose-1-phosphate aldolase; Region: rhamnu_1P_ald; TIGR02624 226185001170 intersubunit interface [polypeptide binding]; other site 226185001171 active site 226185001172 Zn2+ binding site [ion binding]; other site 226185001173 Domain of unknown function (DUF718); Region: DUF718; cl01281 226185001174 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 226185001175 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226185001176 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 226185001177 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 226185001178 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 226185001179 POT family; Region: PTR2; cl17359 226185001180 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226185001181 putative substrate translocation pore; other site 226185001182 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 226185001183 dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396 226185001184 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 226185001185 substrate binding site [chemical binding]; other site 226185001186 oxyanion hole (OAH) forming residues; other site 226185001187 trimer interface [polypeptide binding]; other site 226185001188 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 226185001189 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 226185001190 acyl-activating enzyme (AAE) consensus motif; other site 226185001191 putative AMP binding site [chemical binding]; other site 226185001192 putative active site [active] 226185001193 putative CoA binding site [chemical binding]; other site 226185001194 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 226185001195 isochorismate synthases; Region: isochor_syn; TIGR00543 226185001196 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 226185001197 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 226185001198 dimer interface [polypeptide binding]; other site 226185001199 tetramer interface [polypeptide binding]; other site 226185001200 PYR/PP interface [polypeptide binding]; other site 226185001201 TPP binding site [chemical binding]; other site 226185001202 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 226185001203 TPP-binding site; other site 226185001204 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 226185001205 Putative lysophospholipase; Region: Hydrolase_4; cl19140 226185001206 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 226185001207 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 226185001208 active site 226185001209 octamer interface [polypeptide binding]; other site 226185001210 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 226185001211 active site 226185001212 trimer interface [polypeptide binding]; other site 226185001213 allosteric site; other site 226185001214 hexamer (dimer of trimers) interface [polypeptide binding]; other site 226185001215 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 226185001216 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 226185001217 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 226185001218 acyl-activating enzyme (AAE) consensus motif; other site 226185001219 acyl-activating enzyme (AAE) consensus motif; other site 226185001220 AMP binding site [chemical binding]; other site 226185001221 active site 226185001222 CoA binding site [chemical binding]; other site 226185001223 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 226185001224 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 226185001225 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 226185001226 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 226185001227 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 226185001228 active site 226185001229 phosphorylation site [posttranslational modification] 226185001230 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 226185001231 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 226185001232 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 226185001233 putative active site [active] 226185001234 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 226185001235 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 226185001236 putative active site [active] 226185001237 Beta-lactamase; Region: Beta-lactamase; pfam00144 226185001238 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 226185001239 active pocket/dimerization site; other site 226185001240 active site 226185001241 phosphorylation site [posttranslational modification] 226185001242 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 226185001243 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 226185001244 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 226185001245 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 226185001246 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 226185001247 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 226185001248 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 226185001249 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 226185001250 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 226185001251 active site 226185001252 trimer interface [polypeptide binding]; other site 226185001253 allosteric site; other site 226185001254 active site lid [active] 226185001255 hexamer (dimer of trimers) interface [polypeptide binding]; other site 226185001256 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 226185001257 MgtC family; Region: MgtC; pfam02308 226185001258 LemA family; Region: LemA; cl00742 226185001259 TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase; Region: TPM; cl01535 226185001260 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 226185001261 dimer interface [polypeptide binding]; other site 226185001262 putative radical transfer pathway; other site 226185001263 diiron center [ion binding]; other site 226185001264 tyrosyl radical; other site 226185001265 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 226185001266 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 226185001267 Class I ribonucleotide reductase; Region: RNR_I; cd01679 226185001268 active site 226185001269 dimer interface [polypeptide binding]; other site 226185001270 catalytic residues [active] 226185001271 effector binding site; other site 226185001272 R2 peptide binding site; other site 226185001273 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 226185001274 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 226185001275 catalytic residues [active] 226185001276 FeoA domain; Region: FeoA; pfam04023 226185001277 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 226185001278 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 226185001279 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 226185001280 G1 box; other site 226185001281 GTP/Mg2+ binding site [chemical binding]; other site 226185001282 Switch I region; other site 226185001283 G2 box; other site 226185001284 G3 box; other site 226185001285 Switch II region; other site 226185001286 G4 box; other site 226185001287 G5 box; other site 226185001288 Nucleoside recognition; Region: Gate; pfam07670 226185001289 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 226185001290 Nucleoside recognition; Region: Gate; pfam07670 226185001291 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 226185001292 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 226185001293 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 226185001294 Int/Topo IB signature motif; other site 226185001295 Helix-turn-helix domain; Region: HTH_17; cl17695 226185001296 Helix-turn-helix domain; Region: HTH_16; pfam12645 226185001297 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 226185001298 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 226185001299 DNA binding residues [nucleotide binding] 226185001300 putative protease; Region: PHA00666 226185001301 Glucan-binding protein C; Region: GbpC; pfam08363 226185001302 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 226185001303 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 226185001304 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 226185001305 PrgU-like protein; Region: PrgU; pfam09627 226185001306 hypothetical protein; Provisional; Region: PRK05849 226185001307 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 226185001308 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 226185001309 CHAP domain; Region: CHAP; pfam05257 226185001310 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 226185001311 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 226185001312 TcpE family; Region: TcpE; pfam12648 226185001313 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 226185001314 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 226185001315 dimer interface [polypeptide binding]; other site 226185001316 ssDNA binding site [nucleotide binding]; other site 226185001317 tetramer (dimer of dimers) interface [polypeptide binding]; other site 226185001318 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 226185001319 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 226185001320 AAA-like domain; Region: AAA_10; pfam12846 226185001321 Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; cl19582 226185001322 Cdc37 N terminal kinase binding; Region: CDC37_N; cl03951 226185001323 Domain of unknown function DUF87; Region: DUF87; cl19135 226185001324 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 226185001325 Replication-relaxation; Region: Replic_Relax; pfam13814 226185001326 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 226185001327 HSP70 interaction site [polypeptide binding]; other site 226185001328 Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961 226185001329 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 226185001330 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 226185001331 dimer interface [polypeptide binding]; other site 226185001332 ssDNA binding site [nucleotide binding]; other site 226185001333 tetramer (dimer of dimers) interface [polypeptide binding]; other site 226185001334 Staphylococcal nuclease homologues; Region: SNc; smart00318 226185001335 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 226185001336 Catalytic site; other site 226185001337 addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384 226185001338 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 226185001339 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 226185001340 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 226185001341 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 226185001342 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 226185001343 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 226185001344 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 226185001345 active site 226185001346 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226185001347 non-specific DNA binding site [nucleotide binding]; other site 226185001348 salt bridge; other site 226185001349 sequence-specific DNA binding site [nucleotide binding]; other site 226185001350 type 2 lantibiotic, SP_1948 family; Region: lant_SP_1948; TIGR03893 226185001351 type 2 lantibiotic, SP_1948 family; Region: lant_SP_1948; TIGR03893 226185001352 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 226185001353 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 226185001354 active site 226185001355 zinc binding site [ion binding]; other site 226185001356 Transposase, Mutator family; Region: Transposase_mut; pfam00872 226185001357 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 226185001358 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226185001359 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226185001360 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226185001361 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 226185001362 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 226185001363 Presynaptic Site I dimer interface [polypeptide binding]; other site 226185001364 catalytic residues [active] 226185001365 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 226185001366 Synaptic Flat tetramer interface [polypeptide binding]; other site 226185001367 Synaptic Site I dimer interface [polypeptide binding]; other site 226185001368 DNA binding site [nucleotide binding] 226185001369 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 226185001370 DNA-binding interface [nucleotide binding]; DNA binding site 226185001371 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 226185001372 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 226185001373 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 226185001374 putative active site [active] 226185001375 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 226185001376 putative active site cavity [active] 226185001377 YibE/F-like protein; Region: YibE_F; pfam07907 226185001378 YibE/F-like protein; Region: YibE_F; pfam07907 226185001379 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 226185001380 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 226185001381 trimer interface [polypeptide binding]; other site 226185001382 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 226185001383 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 226185001384 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 226185001385 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 226185001386 Transcriptional regulators [Transcription]; Region: MarR; COG1846 226185001387 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 226185001388 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 226185001389 nucleotide binding site [chemical binding]; other site 226185001390 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 226185001391 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 226185001392 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 226185001393 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 226185001394 putative active site [active] 226185001395 putative catalytic site [active] 226185001396 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 226185001397 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 226185001398 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 226185001399 active site 226185001400 phosphorylation site [posttranslational modification] 226185001401 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 226185001402 active pocket/dimerization site; other site 226185001403 active site 226185001404 phosphorylation site [posttranslational modification] 226185001405 xylose isomerase; Provisional; Region: PRK05474 226185001406 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 226185001407 N- and C-terminal domain interface [polypeptide binding]; other site 226185001408 D-xylulose kinase; Region: XylB; TIGR01312 226185001409 active site 226185001410 MgATP binding site [chemical binding]; other site 226185001411 catalytic site [active] 226185001412 metal binding site [ion binding]; metal-binding site 226185001413 xylulose binding site [chemical binding]; other site 226185001414 homodimer interface [polypeptide binding]; other site 226185001415 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 226185001416 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 226185001417 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 226185001418 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 226185001419 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 226185001420 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 226185001421 Soluble P-type ATPase [General function prediction only]; Region: COG4087 226185001422 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 226185001423 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 226185001424 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 226185001425 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 226185001426 Ligand Binding Site [chemical binding]; other site 226185001427 GAF domain; Region: GAF_3; pfam13492 226185001428 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226185001429 dimer interface [polypeptide binding]; other site 226185001430 phosphorylation site [posttranslational modification] 226185001431 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226185001432 ATP binding site [chemical binding]; other site 226185001433 Mg2+ binding site [ion binding]; other site 226185001434 G-X-G motif; other site 226185001435 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226185001436 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226185001437 active site 226185001438 phosphorylation site [posttranslational modification] 226185001439 intermolecular recognition site; other site 226185001440 dimerization interface [polypeptide binding]; other site 226185001441 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226185001442 DNA binding site [nucleotide binding] 226185001443 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 226185001444 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 226185001445 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 226185001446 ABC-ATPase subunit interface; other site 226185001447 dimer interface [polypeptide binding]; other site 226185001448 putative PBP binding regions; other site 226185001449 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 226185001450 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 226185001451 metal binding site [ion binding]; metal-binding site 226185001452 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 226185001453 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226185001454 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 226185001455 Cobalt transport protein; Region: CbiQ; cl00463 226185001456 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 226185001457 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 226185001458 Walker A/P-loop; other site 226185001459 ATP binding site [chemical binding]; other site 226185001460 Q-loop/lid; other site 226185001461 ABC transporter signature motif; other site 226185001462 Walker B; other site 226185001463 D-loop; other site 226185001464 H-loop/switch region; other site 226185001465 Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226 226185001466 Walker A/P-loop; other site 226185001467 ATP binding site [chemical binding]; other site 226185001468 Q-loop/lid; other site 226185001469 ABC transporter signature motif; other site 226185001470 Walker B; other site 226185001471 D-loop; other site 226185001472 H-loop/switch region; other site 226185001473 conserved hypothetical integral membrane protein TIGR02185; Region: Trep_Strep 226185001474 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 226185001475 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 226185001476 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226185001477 Walker A/P-loop; other site 226185001478 ATP binding site [chemical binding]; other site 226185001479 Q-loop/lid; other site 226185001480 ABC transporter signature motif; other site 226185001481 Walker B; other site 226185001482 D-loop; other site 226185001483 H-loop/switch region; other site 226185001484 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 226185001485 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 226185001486 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226185001487 Walker A/P-loop; other site 226185001488 ATP binding site [chemical binding]; other site 226185001489 Q-loop/lid; other site 226185001490 ABC transporter signature motif; other site 226185001491 Walker B; other site 226185001492 D-loop; other site 226185001493 H-loop/switch region; other site 226185001494 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 226185001495 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 226185001496 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 226185001497 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 226185001498 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 226185001499 Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954 226185001500 NodB motif; other site 226185001501 active site 226185001502 catalytic site [active] 226185001503 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 226185001504 Transposase, Mutator family; Region: Transposase_mut; cl19537 226185001505 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226185001506 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 226185001507 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226185001508 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 226185001509 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 226185001510 Ferritin-like domain; Region: Ferritin; pfam00210 226185001511 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 226185001512 dimerization interface [polypeptide binding]; other site 226185001513 DPS ferroxidase diiron center [ion binding]; other site 226185001514 ion pore; other site 226185001515 ParB-like nuclease domain; Region: ParBc; pfam02195 226185001516 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 226185001517 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 226185001518 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 226185001519 Active Sites [active] 226185001520 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 226185001521 TcpE family; Region: TcpE; pfam12648 226185001522 Transposase IS200 like; Region: Y1_Tnp; pfam01797 226185001523 ornithine cyclodeaminase; Validated; Region: PRK08618 226185001524 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; cl19124 226185001525 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 226185001526 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 226185001527 Predicted transcriptional regulators [Transcription]; Region: COG1378 226185001528 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 226185001529 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 226185001530 C-terminal domain interface [polypeptide binding]; other site 226185001531 sugar binding site [chemical binding]; other site 226185001532 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 226185001533 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 226185001534 active pocket/dimerization site; other site 226185001535 active site 226185001536 phosphorylation site [posttranslational modification] 226185001537 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 226185001538 active site 226185001539 catalytic tetrad [active] 226185001540 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 226185001541 active site 226185001542 metal binding site [ion binding]; metal-binding site 226185001543 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 226185001544 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 226185001545 putative active site [active] 226185001546 catalytic site [active] 226185001547 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 226185001548 putative active site [active] 226185001549 catalytic site [active] 226185001550 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 226185001551 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 226185001552 active site 226185001553 HIGH motif; other site 226185001554 dimer interface [polypeptide binding]; other site 226185001555 KMSKS motif; other site 226185001556 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 226185001557 RNA binding surface [nucleotide binding]; other site 226185001558 tyrosine decarboxylase, Enterococcus type; Region: tyr_de_CO2_Ent; TIGR03811 226185001559 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 226185001560 catalytic residue [active] 226185001561 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 226185001562 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 226185001563 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 226185001564 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 226185001565 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 226185001566 Protein of unknown function (DUF1307); Region: DUF1307; pfam06998 226185001567 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 226185001568 tetramer interfaces [polypeptide binding]; other site 226185001569 binuclear metal-binding site [ion binding]; other site 226185001570 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 226185001571 tetramer (dimer of dimers) interface [polypeptide binding]; other site 226185001572 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 226185001573 NAD binding site [chemical binding]; other site 226185001574 dimer interface [polypeptide binding]; other site 226185001575 substrate binding site [chemical binding]; other site 226185001576 Transcriptional regulator [Transcription]; Region: LysR; COG0583 226185001577 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 226185001578 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 226185001579 dimerization interface [polypeptide binding]; other site 226185001580 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 226185001581 gating phenylalanine in ion channel; other site 226185001582 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 226185001583 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226185001584 NAD(P) binding site [chemical binding]; other site 226185001585 active site 226185001586 Predicted transcriptional regulators [Transcription]; Region: COG1733 226185001587 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 226185001588 dimer interface [polypeptide binding]; other site 226185001589 FMN binding site [chemical binding]; other site 226185001590 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 226185001591 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 226185001592 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 226185001593 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 226185001594 Transcriptional regulators [Transcription]; Region: PurR; COG1609 226185001595 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 226185001596 DNA binding site [nucleotide binding] 226185001597 domain linker motif; other site 226185001598 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 226185001599 putative dimerization interface [polypeptide binding]; other site 226185001600 putative ligand binding site [chemical binding]; other site 226185001601 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 226185001602 dimer interface [polypeptide binding]; other site 226185001603 FMN binding site [chemical binding]; other site 226185001604 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 226185001605 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 226185001606 putative metal binding site [ion binding]; other site 226185001607 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 226185001608 active site 226185001609 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 226185001610 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 226185001611 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 226185001612 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 226185001613 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 226185001614 active site 226185001615 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 226185001616 active site 226185001617 Fe-S cluster binding site [ion binding]; other site 226185001618 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 226185001619 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 226185001620 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 226185001621 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 226185001622 active site 226185001623 Zn binding site [ion binding]; other site 226185001624 Predicted integral membrane protein [Function unknown]; Region: COG5652 226185001625 hypothetical protein; Validated; Region: PRK00110 226185001626 C_GCAxxG_C_C family probable redox protein; Region: C_GCAxxG_C_C; TIGR01909 226185001627 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 226185001628 Zn binding site [ion binding]; other site 226185001629 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 226185001630 Zn binding site [ion binding]; other site 226185001631 putative hydrolase; Provisional; Region: PRK11460 226185001632 Predicted esterase [General function prediction only]; Region: COG0400 226185001633 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 226185001634 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 226185001635 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 226185001636 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 226185001637 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 226185001638 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 226185001639 dipeptidase PepV; Region: dipeptidase; TIGR01886 226185001640 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 226185001641 active site 226185001642 metal binding site [ion binding]; metal-binding site 226185001643 DNA primase large subunit; Validated; Region: PRK03968 226185001644 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 226185001645 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 226185001646 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226185001647 Walker A/P-loop; other site 226185001648 ATP binding site [chemical binding]; other site 226185001649 Q-loop/lid; other site 226185001650 ABC transporter signature motif; other site 226185001651 Walker B; other site 226185001652 D-loop; other site 226185001653 H-loop/switch region; other site 226185001654 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226185001655 dimer interface [polypeptide binding]; other site 226185001656 conserved gate region; other site 226185001657 putative PBP binding loops; other site 226185001658 ABC-ATPase subunit interface; other site 226185001659 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 226185001660 Arginine repressor [Transcription]; Region: ArgR; COG1438 226185001661 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 226185001662 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 226185001663 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 226185001664 active site 226185001665 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 226185001666 substrate binding site [chemical binding]; other site 226185001667 metal binding site [ion binding]; metal-binding site 226185001668 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 226185001669 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 226185001670 Transglycosylase; Region: Transgly; pfam00912 226185001671 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 226185001672 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 226185001673 hypothetical protein; Provisional; Region: PRK13676 226185001674 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 226185001675 active site 226185001676 metal binding site [ion binding]; metal-binding site 226185001677 DNA binding site [nucleotide binding] 226185001678 Uncharacterized conserved protein [Function unknown]; Region: COG4717 226185001679 AAA domain; Region: AAA_23; pfam13476 226185001680 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 226185001681 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 226185001682 generic binding surface II; other site 226185001683 generic binding surface I; other site 226185001684 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 226185001685 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 226185001686 Zn2+ binding site [ion binding]; other site 226185001687 Mg2+ binding site [ion binding]; other site 226185001688 foldase protein PrsA; Reviewed; Region: prsA; PRK01326 226185001689 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 226185001690 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 226185001691 YtxH-like protein; Region: YtxH; pfam12732 226185001692 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 226185001693 HIT family signature motif; other site 226185001694 catalytic residue [active] 226185001695 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 226185001696 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 226185001697 Walker A/P-loop; other site 226185001698 ATP binding site [chemical binding]; other site 226185001699 Q-loop/lid; other site 226185001700 ABC transporter signature motif; other site 226185001701 Walker B; other site 226185001702 D-loop; other site 226185001703 H-loop/switch region; other site 226185001704 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 226185001705 Thiamine kinase and related kinases [Coenzyme transport and metabolism]; Region: ycfN; COG0510 226185001706 Phosphotransferase enzyme family; Region: APH; pfam01636 226185001707 active site 226185001708 substrate binding site [chemical binding]; other site 226185001709 ATP binding site [chemical binding]; other site 226185001710 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226185001711 S-adenosylmethionine binding site [chemical binding]; other site 226185001712 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 226185001713 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 226185001714 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 226185001715 putative active site [active] 226185001716 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 226185001717 putative substrate binding site [chemical binding]; other site 226185001718 putative ATP binding site [chemical binding]; other site 226185001719 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 226185001720 active site 226185001721 P-loop; other site 226185001722 phosphorylation site [posttranslational modification] 226185001723 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 226185001724 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 226185001725 active site 226185001726 phosphorylation site [posttranslational modification] 226185001727 Class I aldolases; Region: Aldolase_Class_I; cl17187 226185001728 hypothetical protein; Provisional; Region: PRK13662 226185001729 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 226185001730 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226185001731 Coenzyme A binding pocket [chemical binding]; other site 226185001732 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 226185001733 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 226185001734 Domain of unknown function DUF21; Region: DUF21; pfam01595 226185001735 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 226185001736 Transporter associated domain; Region: CorC_HlyC; pfam03471 226185001737 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 226185001738 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 226185001739 G1 box; other site 226185001740 putative GEF interaction site [polypeptide binding]; other site 226185001741 GTP/Mg2+ binding site [chemical binding]; other site 226185001742 Switch I region; other site 226185001743 G2 box; other site 226185001744 G3 box; other site 226185001745 Switch II region; other site 226185001746 G4 box; other site 226185001747 G5 box; other site 226185001748 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 226185001749 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 226185001750 Predicted membrane protein [Function unknown]; Region: COG2323 226185001751 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 226185001752 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226185001753 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 226185001754 Walker A motif; other site 226185001755 ATP binding site [chemical binding]; other site 226185001756 Walker B motif; other site 226185001757 arginine finger; other site 226185001758 UvrB/uvrC motif; Region: UVR; pfam02151 226185001759 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226185001760 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 226185001761 Walker A motif; other site 226185001762 ATP binding site [chemical binding]; other site 226185001763 Walker B motif; other site 226185001764 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 226185001765 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 226185001766 dimerization domain swap beta strand [polypeptide binding]; other site 226185001767 regulatory protein interface [polypeptide binding]; other site 226185001768 active site 226185001769 regulatory phosphorylation site [posttranslational modification]; other site 226185001770 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 226185001771 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 226185001772 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 226185001773 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 226185001774 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 226185001775 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 226185001776 WxL domain surface cell wall-binding; Region: WxL; pfam13731 226185001777 trigger factor; Provisional; Region: tig; PRK01490 226185001778 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 226185001779 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 226185001780 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 226185001781 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 226185001782 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 226185001783 active site 226185001784 phosphorylation site [posttranslational modification] 226185001785 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 226185001786 active site 226185001787 P-loop; other site 226185001788 phosphorylation site [posttranslational modification] 226185001789 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 226185001790 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 226185001791 putative substrate binding site [chemical binding]; other site 226185001792 putative ATP binding site [chemical binding]; other site 226185001793 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 226185001794 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 226185001795 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 226185001796 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 226185001797 Cl- selectivity filter; other site 226185001798 Cl- binding residues [ion binding]; other site 226185001799 pore gating glutamate residue; other site 226185001800 dimer interface [polypeptide binding]; other site 226185001801 H+/Cl- coupling transport residue; other site 226185001802 TrkA-C domain; Region: TrkA_C; pfam02080 226185001803 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 226185001804 Part of AAA domain; Region: AAA_19; pfam13245 226185001805 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 226185001806 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 226185001807 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 226185001808 nucleotide binding pocket [chemical binding]; other site 226185001809 K-X-D-G motif; other site 226185001810 catalytic site [active] 226185001811 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 226185001812 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 226185001813 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 226185001814 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 226185001815 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 226185001816 Dimer interface [polypeptide binding]; other site 226185001817 BRCT sequence motif; other site 226185001818 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 226185001819 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 226185001820 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 226185001821 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 226185001822 GatB domain; Region: GatB_Yqey; pfam02637 226185001823 putative lipid kinase; Reviewed; Region: PRK13055 226185001824 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 226185001825 TRAM domain; Region: TRAM; cl01282 226185001826 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 226185001827 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226185001828 S-adenosylmethionine binding site [chemical binding]; other site 226185001829 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 226185001830 catalytic residues [active] 226185001831 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 226185001832 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 226185001833 DNA binding residues [nucleotide binding] 226185001834 dimerization interface [polypeptide binding]; other site 226185001835 putrescine carbamoyltransferase; Provisional; Region: PRK02255 226185001836 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 226185001837 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 226185001838 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 226185001839 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 226185001840 agmatine deiminase; Provisional; Region: PRK13551 226185001841 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 226185001842 putative substrate binding site [chemical binding]; other site 226185001843 nucleotide binding site [chemical binding]; other site 226185001844 nucleotide binding site [chemical binding]; other site 226185001845 homodimer interface [polypeptide binding]; other site 226185001846 amidase; Provisional; Region: PRK06707 226185001847 nicotinamide mononucleotide transporter PnuC; Region: NMN_trans_PnuC; TIGR01528 226185001848 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 226185001849 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 226185001850 Substrate-binding site [chemical binding]; other site 226185001851 Substrate specificity [chemical binding]; other site 226185001852 Protein of unknown function (DUF1149); Region: DUF1149; pfam06619 226185001853 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 226185001854 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 226185001855 Beta-lactamase; Region: Beta-lactamase; pfam00144 226185001856 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 226185001857 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 226185001858 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 226185001859 active site residue [active] 226185001860 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 226185001861 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 226185001862 WxL domain surface cell wall-binding; Region: WxL; pfam13731 226185001863 WxL domain surface cell wall-binding; Region: WxL; pfam13731 226185001864 legume lectins; Region: lectin_L-type; cd01951 226185001865 homotetramer interaction site [polypeptide binding]; other site 226185001866 homodimer interaction site [polypeptide binding]; other site 226185001867 carbohydrate binding site [chemical binding]; other site 226185001868 metal binding site [ion binding]; metal-binding site 226185001869 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 226185001870 WxL domain surface cell wall-binding; Region: WxL; pfam13731 226185001871 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 226185001872 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 226185001873 Mga helix-turn-helix domain; Region: Mga; pfam05043 226185001874 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 226185001875 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 226185001876 Soluble P-type ATPase [General function prediction only]; Region: COG4087 226185001877 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 226185001878 MgtC family; Region: MgtC; pfam02308 226185001879 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 226185001880 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 226185001881 Walker A/P-loop; other site 226185001882 ATP binding site [chemical binding]; other site 226185001883 Q-loop/lid; other site 226185001884 ABC transporter signature motif; other site 226185001885 Walker B; other site 226185001886 D-loop; other site 226185001887 H-loop/switch region; other site 226185001888 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 226185001889 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 226185001890 substrate binding pocket [chemical binding]; other site 226185001891 membrane-bound complex binding site; other site 226185001892 hinge residues; other site 226185001893 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 226185001894 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 226185001895 substrate binding pocket [chemical binding]; other site 226185001896 membrane-bound complex binding site; other site 226185001897 hinge residues; other site 226185001898 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 226185001899 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226185001900 dimer interface [polypeptide binding]; other site 226185001901 conserved gate region; other site 226185001902 putative PBP binding loops; other site 226185001903 ABC-ATPase subunit interface; other site 226185001904 excinuclease ABC subunit B; Provisional; Region: PRK05298 226185001905 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226185001906 ATP binding site [chemical binding]; other site 226185001907 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226185001908 nucleotide binding region [chemical binding]; other site 226185001909 ATP-binding site [chemical binding]; other site 226185001910 Ultra-violet resistance protein B; Region: UvrB; pfam12344 226185001911 UvrB/uvrC motif; Region: UVR; pfam02151 226185001912 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 226185001913 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 226185001914 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 226185001915 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 226185001916 YusW-like protein; Region: YusW; pfam14039 226185001917 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 226185001918 AAA domain; Region: AAA_33; pfam13671 226185001919 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 226185001920 phosphate binding site [ion binding]; other site 226185001921 putative substrate binding pocket [chemical binding]; other site 226185001922 dimer interface [polypeptide binding]; other site 226185001923 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 226185001924 WhiA N-terminal LAGLIDADG-like domain; Region: WhiA_N; pfam10298 226185001925 WhiA LAGLIDADG-like domain; Region: LAGLIDADG_WhiA; pfam14527 226185001926 WhiA C-terminal HTH domain; Region: HTH_WhiA; pfam02650 226185001927 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 226185001928 Thioredoxin; Region: Thioredoxin_4; pfam13462 226185001929 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 226185001930 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 226185001931 oligomer interface [polypeptide binding]; other site 226185001932 active site residues [active] 226185001933 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 226185001934 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 226185001935 metal ion-dependent adhesion site (MIDAS); other site 226185001936 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 226185001937 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 226185001938 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 226185001939 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 226185001940 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 226185001941 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 226185001942 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 226185001943 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 226185001944 putative active site [active] 226185001945 catalytic site [active] 226185001946 putative metal binding site [ion binding]; other site 226185001947 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 226185001948 nudix motif; other site 226185001949 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 226185001950 DNA-binding site [nucleotide binding]; DNA binding site 226185001951 RNA-binding motif; other site 226185001952 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 226185001953 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 226185001954 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 226185001955 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 226185001956 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 226185001957 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 226185001958 catalytic triad [active] 226185001959 catalytic triad [active] 226185001960 oxyanion hole [active] 226185001961 S-adenosylmethionine synthetase; Validated; Region: PRK05250 226185001962 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 226185001963 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 226185001964 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 226185001965 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226185001966 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226185001967 putative substrate translocation pore; other site 226185001968 Predicted esterase [General function prediction only]; Region: COG0627 226185001969 S-formylglutathione hydrolase; Region: PLN02442 226185001970 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 226185001971 tetracycline repressor protein TetR; Provisional; Region: PRK13756 226185001972 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 226185001973 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 226185001974 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 226185001975 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226185001976 Walker A/P-loop; other site 226185001977 ATP binding site [chemical binding]; other site 226185001978 Q-loop/lid; other site 226185001979 ABC transporter signature motif; other site 226185001980 Walker B; other site 226185001981 D-loop; other site 226185001982 H-loop/switch region; other site 226185001983 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 226185001984 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 226185001985 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226185001986 Walker A/P-loop; other site 226185001987 ATP binding site [chemical binding]; other site 226185001988 Q-loop/lid; other site 226185001989 ABC transporter signature motif; other site 226185001990 Walker B; other site 226185001991 D-loop; other site 226185001992 H-loop/switch region; other site 226185001993 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226185001994 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 226185001995 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 226185001996 FtsX-like permease family; Region: FtsX; pfam02687 226185001997 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 226185001998 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 226185001999 Walker A/P-loop; other site 226185002000 ATP binding site [chemical binding]; other site 226185002001 Q-loop/lid; other site 226185002002 ABC transporter signature motif; other site 226185002003 Walker B; other site 226185002004 D-loop; other site 226185002005 H-loop/switch region; other site 226185002006 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 226185002007 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 226185002008 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 226185002009 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 226185002010 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 226185002011 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 226185002012 active site 226185002013 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 226185002014 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 226185002015 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 226185002016 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 226185002017 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 226185002018 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 226185002019 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 226185002020 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 226185002021 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 226185002022 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 226185002023 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 226185002024 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 226185002025 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 226185002026 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 226185002027 active site 226185002028 HIGH motif; other site 226185002029 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 226185002030 KMSKS motif; other site 226185002031 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 226185002032 tRNA binding surface [nucleotide binding]; other site 226185002033 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 226185002034 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 226185002035 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 226185002036 substrate binding pocket [chemical binding]; other site 226185002037 membrane-bound complex binding site; other site 226185002038 hinge residues; other site 226185002039 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 226185002040 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226185002041 Walker A/P-loop; other site 226185002042 ATP binding site [chemical binding]; other site 226185002043 Q-loop/lid; other site 226185002044 ABC transporter signature motif; other site 226185002045 Walker B; other site 226185002046 D-loop; other site 226185002047 H-loop/switch region; other site 226185002048 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 226185002049 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226185002050 dimer interface [polypeptide binding]; other site 226185002051 conserved gate region; other site 226185002052 putative PBP binding loops; other site 226185002053 ABC-ATPase subunit interface; other site 226185002054 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 226185002055 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 226185002056 peptide binding site [polypeptide binding]; other site 226185002057 Transglycosylase associated protein; Region: Transgly_assoc; pfam04226 226185002058 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 226185002059 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 226185002060 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 226185002061 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 226185002062 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226185002063 DNA-binding site [nucleotide binding]; DNA binding site 226185002064 UTRA domain; Region: UTRA; pfam07702 226185002065 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 226185002066 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 226185002067 active pocket/dimerization site; other site 226185002068 active site 226185002069 phosphorylation site [posttranslational modification] 226185002070 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 226185002071 active site 226185002072 phosphorylation site [posttranslational modification] 226185002073 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 226185002074 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 226185002075 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 226185002076 substrate binding site [chemical binding]; other site 226185002077 catalytic residues [active] 226185002078 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 226185002079 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 226185002080 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 226185002081 5S rRNA interface [nucleotide binding]; other site 226185002082 CTC domain interface [polypeptide binding]; other site 226185002083 L16 interface [polypeptide binding]; other site 226185002084 Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693 226185002085 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 226185002086 HAD-hyrolase-like; Region: Hydrolase_like; cl19142 226185002087 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226185002088 motif II; other site 226185002089 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 226185002090 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226185002091 Coenzyme A binding pocket [chemical binding]; other site 226185002092 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 226185002093 ATP-binding site [chemical binding]; other site 226185002094 Sugar specificity; other site 226185002095 Pyrimidine base specificity; other site 226185002096 PemK-like protein; Region: PemK; pfam02452 226185002097 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 226185002098 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 226185002099 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 226185002100 HTH domain; Region: HTH_11; pfam08279 226185002101 HTH domain; Region: HTH_11; pfam08279 226185002102 PRD domain; Region: PRD; pfam00874 226185002103 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 226185002104 active site 226185002105 P-loop; other site 226185002106 phosphorylation site [posttranslational modification] 226185002107 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 226185002108 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; pfam14272 226185002109 Domain of unknown function (DUF4312); Region: DUF4312; cl11917 226185002110 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 226185002111 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 226185002112 Domain of unknown function (DUF4310); Region: DUF4310; pfam14187 226185002113 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 226185002114 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 226185002115 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 226185002116 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 226185002117 active site 226185002118 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 226185002119 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 226185002120 catalytic residue [active] 226185002121 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 226185002122 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 226185002123 substrate binding site [chemical binding]; other site 226185002124 ATP binding site [chemical binding]; other site 226185002125 DNA gyrase B; Region: DNA_gyraseB; pfam00204 226185002126 ATP binding site [chemical binding]; other site 226185002127 hypothetical protein; Validated; Region: PRK00124 226185002128 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 226185002129 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 226185002130 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 226185002131 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 226185002132 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 226185002133 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 226185002134 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 226185002135 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 226185002136 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 226185002137 ATP binding site [chemical binding]; other site 226185002138 Mg++ binding site [ion binding]; other site 226185002139 motif III; other site 226185002140 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226185002141 nucleotide binding region [chemical binding]; other site 226185002142 ATP-binding site [chemical binding]; other site 226185002143 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 226185002144 alanine racemase; Reviewed; Region: alr; PRK00053 226185002145 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 226185002146 active site 226185002147 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 226185002148 dimer interface [polypeptide binding]; other site 226185002149 substrate binding site [chemical binding]; other site 226185002150 catalytic residues [active] 226185002151 PemK-like protein; Region: PemK; pfam02452 226185002152 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 226185002153 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 226185002154 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 226185002155 Catalytic site [active] 226185002156 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 226185002157 Mga helix-turn-helix domain; Region: Mga; pfam05043 226185002158 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 226185002159 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 226185002160 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 226185002161 Predicted membrane protein [Function unknown]; Region: COG1511 226185002162 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 226185002163 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 226185002164 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226185002165 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 226185002166 Amino acid permease; Region: AA_permease_2; pfam13520 226185002167 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226185002168 Coenzyme A binding pocket [chemical binding]; other site 226185002169 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 226185002170 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226185002171 dimer interface [polypeptide binding]; other site 226185002172 conserved gate region; other site 226185002173 putative PBP binding loops; other site 226185002174 ABC-ATPase subunit interface; other site 226185002175 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 226185002176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226185002177 dimer interface [polypeptide binding]; other site 226185002178 conserved gate region; other site 226185002179 putative PBP binding loops; other site 226185002180 ABC-ATPase subunit interface; other site 226185002181 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226185002182 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 226185002183 Walker A/P-loop; other site 226185002184 ATP binding site [chemical binding]; other site 226185002185 Q-loop/lid; other site 226185002186 ABC transporter signature motif; other site 226185002187 Walker B; other site 226185002188 D-loop; other site 226185002189 H-loop/switch region; other site 226185002190 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 226185002191 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 226185002192 Zn binding site [ion binding]; other site 226185002193 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 226185002194 Zn binding site [ion binding]; other site 226185002195 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 226185002196 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226185002197 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226185002198 salt bridge; other site 226185002199 non-specific DNA binding site [nucleotide binding]; other site 226185002200 sequence-specific DNA binding site [nucleotide binding]; other site 226185002201 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 226185002202 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 226185002203 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 226185002204 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 226185002205 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226185002206 motif II; other site 226185002207 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 226185002208 K+ potassium transporter; Region: K_trans; pfam02705 226185002209 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226185002210 non-specific DNA binding site [nucleotide binding]; other site 226185002211 salt bridge; other site 226185002212 sequence-specific DNA binding site [nucleotide binding]; other site 226185002213 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 226185002214 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 226185002215 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 226185002216 Soluble P-type ATPase [General function prediction only]; Region: COG4087 226185002217 Mga helix-turn-helix domain; Region: Mga; pfam05043 226185002218 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 226185002219 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 226185002220 active site 226185002221 catalytic tetrad [active] 226185002222 DNA polymerase I; Provisional; Region: PRK05755 226185002223 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 226185002224 active site 226185002225 metal binding site 1 [ion binding]; metal-binding site 226185002226 putative 5' ssDNA interaction site; other site 226185002227 metal binding site 3; metal-binding site 226185002228 metal binding site 2 [ion binding]; metal-binding site 226185002229 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 226185002230 putative DNA binding site [nucleotide binding]; other site 226185002231 putative metal binding site [ion binding]; other site 226185002232 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 226185002233 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 226185002234 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 226185002235 active site 226185002236 DNA binding site [nucleotide binding] 226185002237 catalytic site [active] 226185002238 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 226185002239 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 226185002240 DNA binding site [nucleotide binding] 226185002241 catalytic residue [active] 226185002242 H2TH interface [polypeptide binding]; other site 226185002243 putative catalytic residues [active] 226185002244 turnover-facilitating residue; other site 226185002245 intercalation triad [nucleotide binding]; other site 226185002246 8OG recognition residue [nucleotide binding]; other site 226185002247 putative reading head residues; other site 226185002248 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 226185002249 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 226185002250 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 226185002251 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 226185002252 CoA-binding site [chemical binding]; other site 226185002253 ATP-binding [chemical binding]; other site 226185002254 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 226185002255 ATP cone domain; Region: ATP-cone; pfam03477 226185002256 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 226185002257 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 226185002258 primosomal protein DnaI; Reviewed; Region: PRK08939 226185002259 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 226185002260 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226185002261 Walker A motif; other site 226185002262 ATP binding site [chemical binding]; other site 226185002263 Walker B motif; other site 226185002264 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 226185002265 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 226185002266 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 226185002267 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 226185002268 DXD motif; other site 226185002269 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 226185002270 aspartate aminotransferase; Provisional; Region: PRK06348 226185002271 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226185002272 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226185002273 homodimer interface [polypeptide binding]; other site 226185002274 catalytic residue [active] 226185002275 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 226185002276 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 226185002277 Walker A/P-loop; other site 226185002278 ATP binding site [chemical binding]; other site 226185002279 Q-loop/lid; other site 226185002280 ABC transporter signature motif; other site 226185002281 Walker B; other site 226185002282 D-loop; other site 226185002283 H-loop/switch region; other site 226185002284 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 226185002285 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 226185002286 substrate binding pocket [chemical binding]; other site 226185002287 membrane-bound complex binding site; other site 226185002288 hinge residues; other site 226185002289 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 226185002290 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226185002291 dimer interface [polypeptide binding]; other site 226185002292 conserved gate region; other site 226185002293 ABC-ATPase subunit interface; other site 226185002294 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 226185002295 putative active site [active] 226185002296 metal binding site [ion binding]; metal-binding site 226185002297 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 226185002298 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 226185002299 Preprotein translocase subunit; Region: YajC; cl00806 226185002300 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 226185002301 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 226185002302 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 226185002303 putative catalytic cysteine [active] 226185002304 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 226185002305 putative active site [active] 226185002306 metal binding site [ion binding]; metal-binding site 226185002307 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 226185002308 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 226185002309 homotetramer interface [polypeptide binding]; other site 226185002310 FMN binding site [chemical binding]; other site 226185002311 homodimer contacts [polypeptide binding]; other site 226185002312 putative active site [active] 226185002313 putative substrate binding site [chemical binding]; other site 226185002314 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 226185002315 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 226185002316 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 226185002317 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 226185002318 diphosphomevalonate decarboxylase; Region: PLN02407 226185002319 mevalonate kinase; Region: mevalon_kin; TIGR00549 226185002320 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 226185002321 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 226185002322 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 226185002323 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 226185002324 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 226185002325 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 226185002326 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 226185002327 peptide binding site [polypeptide binding]; other site 226185002328 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 226185002329 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 226185002330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226185002331 dimer interface [polypeptide binding]; other site 226185002332 conserved gate region; other site 226185002333 putative PBP binding loops; other site 226185002334 ABC-ATPase subunit interface; other site 226185002335 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 226185002336 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 226185002337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226185002338 dimer interface [polypeptide binding]; other site 226185002339 conserved gate region; other site 226185002340 putative PBP binding loops; other site 226185002341 ABC-ATPase subunit interface; other site 226185002342 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 226185002343 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 226185002344 Walker A/P-loop; other site 226185002345 ATP binding site [chemical binding]; other site 226185002346 Q-loop/lid; other site 226185002347 ABC transporter signature motif; other site 226185002348 Walker B; other site 226185002349 D-loop; other site 226185002350 H-loop/switch region; other site 226185002351 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 226185002352 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 226185002353 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 226185002354 Walker A/P-loop; other site 226185002355 ATP binding site [chemical binding]; other site 226185002356 Q-loop/lid; other site 226185002357 ABC transporter signature motif; other site 226185002358 Walker B; other site 226185002359 D-loop; other site 226185002360 H-loop/switch region; other site 226185002361 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 226185002362 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 226185002363 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 226185002364 Probable transposase; Region: OrfB_IS605; pfam01385 226185002365 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 226185002366 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 226185002367 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 226185002368 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 226185002369 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 226185002370 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 226185002371 23S rRNA binding site [nucleotide binding]; other site 226185002372 L21 binding site [polypeptide binding]; other site 226185002373 L13 binding site [polypeptide binding]; other site 226185002374 YjbR; Region: YjbR; pfam04237 226185002375 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 226185002376 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 226185002377 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 226185002378 GrpB protein; Region: GrpB; pfam04229 226185002379 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 226185002380 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 226185002381 Sulfate transporter family; Region: Sulfate_transp; cl19250 226185002382 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 226185002383 Transcriptional regulator [Transcription]; Region: LysR; COG0583 226185002384 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 226185002385 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 226185002386 dimerization interface [polypeptide binding]; other site 226185002387 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 226185002388 dimer interface [polypeptide binding]; other site 226185002389 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 226185002390 dimer interface [polypeptide binding]; other site 226185002391 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226185002392 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226185002393 active site 226185002394 phosphorylation site [posttranslational modification] 226185002395 intermolecular recognition site; other site 226185002396 dimerization interface [polypeptide binding]; other site 226185002397 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226185002398 DNA binding site [nucleotide binding] 226185002399 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226185002400 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226185002401 dimer interface [polypeptide binding]; other site 226185002402 phosphorylation site [posttranslational modification] 226185002403 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226185002404 ATP binding site [chemical binding]; other site 226185002405 Mg2+ binding site [ion binding]; other site 226185002406 G-X-G motif; other site 226185002407 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 226185002408 Sugar transport protein; Region: Sugar_transport; pfam06800 226185002409 amino acid transporter; Region: 2A0306; TIGR00909 226185002410 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 226185002411 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 226185002412 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 226185002413 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 226185002414 active site 226185002415 HIGH motif; other site 226185002416 KMSKS motif; other site 226185002417 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 226185002418 tRNA binding surface [nucleotide binding]; other site 226185002419 anticodon binding site; other site 226185002420 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 226185002421 dimer interface [polypeptide binding]; other site 226185002422 putative tRNA-binding site [nucleotide binding]; other site 226185002423 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 226185002424 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 226185002425 Part of AAA domain; Region: AAA_19; pfam13245 226185002426 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 226185002427 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 226185002428 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 226185002429 active site 226185002430 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 226185002431 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 226185002432 putative active site [active] 226185002433 putative metal binding site [ion binding]; other site 226185002434 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 226185002435 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226185002436 S-adenosylmethionine binding site [chemical binding]; other site 226185002437 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 226185002438 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 226185002439 Walker A/P-loop; other site 226185002440 ATP binding site [chemical binding]; other site 226185002441 Q-loop/lid; other site 226185002442 ABC transporter signature motif; other site 226185002443 Walker B; other site 226185002444 D-loop; other site 226185002445 H-loop/switch region; other site 226185002446 TOBE domain; Region: TOBE_2; pfam08402 226185002447 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 226185002448 active site 226185002449 dimer interfaces [polypeptide binding]; other site 226185002450 catalytic residues [active] 226185002451 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 226185002452 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 226185002453 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 226185002454 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 226185002455 Walker A/P-loop; other site 226185002456 ATP binding site [chemical binding]; other site 226185002457 Q-loop/lid; other site 226185002458 ABC transporter signature motif; other site 226185002459 Walker B; other site 226185002460 D-loop; other site 226185002461 H-loop/switch region; other site 226185002462 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 226185002463 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 226185002464 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226185002465 Walker A/P-loop; other site 226185002466 ATP binding site [chemical binding]; other site 226185002467 Q-loop/lid; other site 226185002468 ABC transporter signature motif; other site 226185002469 Walker B; other site 226185002470 D-loop; other site 226185002471 H-loop/switch region; other site 226185002472 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 226185002473 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 226185002474 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 226185002475 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226185002476 Coenzyme A binding pocket [chemical binding]; other site 226185002477 Tubby C 2; Region: Tub_2; cl02043 226185002478 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226185002479 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 226185002480 active site 226185002481 motif I; other site 226185002482 motif II; other site 226185002483 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 226185002484 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 226185002485 ligand binding site [chemical binding]; other site 226185002486 active site 226185002487 UGI interface [polypeptide binding]; other site 226185002488 catalytic site [active] 226185002489 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 226185002490 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 226185002491 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 226185002492 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226185002493 Coenzyme A binding pocket [chemical binding]; other site 226185002494 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 226185002495 Transcriptional regulators [Transcription]; Region: PurR; COG1609 226185002496 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 226185002497 DNA binding site [nucleotide binding] 226185002498 domain linker motif; other site 226185002499 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 226185002500 putative dimerization interface [polypeptide binding]; other site 226185002501 putative ligand binding site [chemical binding]; other site 226185002502 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 226185002503 active site 226185002504 catalytic residues [active] 226185002505 HAD-hyrolase-like; Region: Hydrolase_like; cl19142 226185002506 beta-phosphoglucomutase; Region: bPGM; TIGR01990 226185002507 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226185002508 motif II; other site 226185002509 maltose phosphorylase; Provisional; Region: PRK13807 226185002510 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 226185002511 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 226185002512 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 226185002513 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 226185002514 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 226185002515 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 226185002516 active site turn [active] 226185002517 phosphorylation site [posttranslational modification] 226185002518 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 226185002519 HPr interaction site; other site 226185002520 glycerol kinase (GK) interaction site [polypeptide binding]; other site 226185002521 active site 226185002522 phosphorylation site [posttranslational modification] 226185002523 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 226185002524 putative catalytic site [active] 226185002525 putative metal binding site [ion binding]; other site 226185002526 putative phosphate binding site [ion binding]; other site 226185002527 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 226185002528 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 226185002529 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 226185002530 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226185002531 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226185002532 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 226185002533 homodimer interface [polypeptide binding]; other site 226185002534 chemical substrate binding site [chemical binding]; other site 226185002535 oligomer interface [polypeptide binding]; other site 226185002536 metal binding site [ion binding]; metal-binding site 226185002537 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 226185002538 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 226185002539 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 226185002540 DNA binding residues [nucleotide binding] 226185002541 drug binding residues [chemical binding]; other site 226185002542 dimer interface [polypeptide binding]; other site 226185002543 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 226185002544 putative dimer interface [polypeptide binding]; other site 226185002545 TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase; Region: TPM; pfam04536 226185002546 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 226185002547 Protein of unknown function (DUF464); Region: DUF464; pfam04327 226185002548 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 226185002549 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 226185002550 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 226185002551 putative active site [active] 226185002552 putative metal binding site [ion binding]; other site 226185002553 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 226185002554 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 226185002555 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 226185002556 active site 226185002557 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 226185002558 metal binding site [ion binding]; metal-binding site 226185002559 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 226185002560 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 226185002561 putative RNA binding site [nucleotide binding]; other site 226185002562 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 226185002563 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 226185002564 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 226185002565 homodimer interface [polypeptide binding]; other site 226185002566 NADP binding site [chemical binding]; other site 226185002567 substrate binding site [chemical binding]; other site 226185002568 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 226185002569 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 226185002570 generic binding surface II; other site 226185002571 generic binding surface I; other site 226185002572 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 226185002573 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 226185002574 substrate binding pocket [chemical binding]; other site 226185002575 chain length determination region; other site 226185002576 active site lid residues [active] 226185002577 substrate-Mg2+ binding site; other site 226185002578 catalytic residues [active] 226185002579 aspartate-rich region 1; other site 226185002580 aspartate-rich region 2; other site 226185002581 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 226185002582 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 226185002583 RNA binding surface [nucleotide binding]; other site 226185002584 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 226185002585 Arginine repressor [Transcription]; Region: ArgR; COG1438 226185002586 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 226185002587 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 226185002588 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 226185002589 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 226185002590 Walker A/P-loop; other site 226185002591 ATP binding site [chemical binding]; other site 226185002592 Q-loop/lid; other site 226185002593 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 226185002594 ABC transporter signature motif; other site 226185002595 Walker B; other site 226185002596 D-loop; other site 226185002597 H-loop/switch region; other site 226185002598 Protein of unknown function (DUF4044); Region: DUF4044; pfam13253 226185002599 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 226185002600 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 226185002601 Cl binding site [ion binding]; other site 226185002602 oligomer interface [polypeptide binding]; other site 226185002603 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 226185002604 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 226185002605 MraZ protein; Region: MraZ; pfam02381 226185002606 MraZ protein; Region: MraZ; pfam02381 226185002607 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 226185002608 Cell division protein FtsL; Region: FtsL; cl11433 226185002609 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 226185002610 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 226185002611 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 226185002612 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 226185002613 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 226185002614 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 226185002615 Mg++ binding site [ion binding]; other site 226185002616 putative catalytic motif [active] 226185002617 putative substrate binding site [chemical binding]; other site 226185002618 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 226185002619 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; cl19125 226185002620 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 226185002621 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 226185002622 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 226185002623 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 226185002624 active site 226185002625 homodimer interface [polypeptide binding]; other site 226185002626 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 226185002627 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 226185002628 Cell division protein FtsQ; Region: FtsQ; pfam03799 226185002629 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 226185002630 Cell division protein FtsA; Region: FtsA; smart00842 226185002631 Cell division protein FtsA; Region: FtsA; pfam14450 226185002632 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 226185002633 cell division protein FtsZ; Validated; Region: PRK09330 226185002634 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 226185002635 nucleotide binding site [chemical binding]; other site 226185002636 SulA interaction site; other site 226185002637 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 226185002638 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 226185002639 catalytic residue [active] 226185002640 Protein of unknown function (DUF552); Region: DUF552; pfam04472 226185002641 YGGT family; Region: YGGT; pfam02325 226185002642 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 226185002643 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 226185002644 RNA binding surface [nucleotide binding]; other site 226185002645 DivIVA protein; Region: DivIVA; pfam05103 226185002646 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 226185002647 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 226185002648 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 226185002649 active site 226185002650 HIGH motif; other site 226185002651 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 226185002652 KMSKS motif; other site 226185002653 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 226185002654 tRNA binding surface [nucleotide binding]; other site 226185002655 anticodon binding site; other site 226185002656 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 226185002657 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 226185002658 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 226185002659 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 226185002660 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 226185002661 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 226185002662 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 226185002663 FeoA domain; Region: FeoA; pfam04023 226185002664 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 226185002665 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 226185002666 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 226185002667 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 226185002668 ATP binding site [chemical binding]; other site 226185002669 putative Mg++ binding site [ion binding]; other site 226185002670 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226185002671 nucleotide binding region [chemical binding]; other site 226185002672 ATP-binding site [chemical binding]; other site 226185002673 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226185002674 putative Zn2+ binding site [ion binding]; other site 226185002675 putative DNA binding site [nucleotide binding]; other site 226185002676 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226185002677 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 226185002678 Walker A motif; other site 226185002679 ATP binding site [chemical binding]; other site 226185002680 Walker B motif; other site 226185002681 arginine finger; other site 226185002682 Transcriptional antiterminator [Transcription]; Region: COG3933 226185002683 PRD domain; Region: PRD; pfam00874 226185002684 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 226185002685 active pocket/dimerization site; other site 226185002686 active site 226185002687 phosphorylation site [posttranslational modification] 226185002688 PRD domain; Region: PRD; pfam00874 226185002689 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 226185002690 active site 226185002691 P-loop; other site 226185002692 phosphorylation site [posttranslational modification] 226185002693 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 226185002694 ABC transporter substrate binding protein; Region: ABC_sub_bind; cl17301 226185002695 Protein of unknown function (DUF3188); Region: DUF3188; pfam11384 226185002696 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 226185002697 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 226185002698 active site 226185002699 P-loop; other site 226185002700 phosphorylation site [posttranslational modification] 226185002701 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 226185002702 active site 226185002703 methionine cluster; other site 226185002704 phosphorylation site [posttranslational modification] 226185002705 metal binding site [ion binding]; metal-binding site 226185002706 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 226185002707 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 226185002708 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 226185002709 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 226185002710 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 226185002711 Sterol carrier protein domain; Region: SCP2_2; pfam13530 226185002712 Uncharacterized conserved protein [Function unknown]; Region: COG1359 226185002713 pyruvate, phosphate dikinase; Region: pyru_phos_dikin; TIGR01828 226185002714 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 226185002715 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 226185002716 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 226185002717 HTH domain; Region: HTH_11; pfam08279 226185002718 FOG: CBS domain [General function prediction only]; Region: COG0517 226185002719 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 226185002720 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 226185002721 Putative lysophospholipase; Region: Hydrolase_4; cl19140 226185002722 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 226185002723 AAA domain; Region: AAA_18; pfam13238 226185002724 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 226185002725 putative catalytic site [active] 226185002726 putative metal binding site [ion binding]; other site 226185002727 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 226185002728 putative catalytic site [active] 226185002729 putative phosphate binding site [ion binding]; other site 226185002730 putative phosphate binding site [ion binding]; other site 226185002731 putative metal binding site [ion binding]; other site 226185002732 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 226185002733 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 226185002734 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 226185002735 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226185002736 Walker A/P-loop; other site 226185002737 ATP binding site [chemical binding]; other site 226185002738 Q-loop/lid; other site 226185002739 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cl19048 226185002740 ABC transporter signature motif; other site 226185002741 Walker B; other site 226185002742 D-loop; other site 226185002743 H-loop/switch region; other site 226185002744 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951 226185002745 Phosphotransferase enzyme family; Region: APH; pfam01636 226185002746 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 226185002747 active site 226185002748 ATP binding site [chemical binding]; other site 226185002749 Nucleoside diphosphate kinase; Region: NDK; pfam00334 226185002750 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 226185002751 active site 226185002752 multimer interface [polypeptide binding]; other site 226185002753 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226185002754 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226185002755 homodimer interface [polypeptide binding]; other site 226185002756 catalytic residue [active] 226185002757 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226185002758 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 226185002759 active site 226185002760 motif I; other site 226185002761 motif II; other site 226185002762 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 226185002763 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 226185002764 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 226185002765 Sulfate transporter family; Region: Sulfate_transp; cl19250 226185002766 drug efflux system protein MdtG; Provisional; Region: PRK09874 226185002767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226185002768 putative substrate translocation pore; other site 226185002769 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 226185002770 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 226185002771 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 226185002772 active site 226185002773 PHP Thumb interface [polypeptide binding]; other site 226185002774 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 226185002775 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 226185002776 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 226185002777 generic binding surface II; other site 226185002778 generic binding surface I; other site 226185002779 6-phosphofructokinase; Provisional; Region: PRK03202 226185002780 active site 226185002781 ADP/pyrophosphate binding site [chemical binding]; other site 226185002782 dimerization interface [polypeptide binding]; other site 226185002783 allosteric effector site; other site 226185002784 fructose-1,6-bisphosphate binding site; other site 226185002785 pyruvate kinase; Provisional; Region: PRK06354 226185002786 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 226185002787 domain interfaces; other site 226185002788 active site 226185002789 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; cl17700 226185002790 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 226185002791 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 226185002792 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 226185002793 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 226185002794 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 226185002795 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226185002796 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226185002797 active site 226185002798 phosphorylation site [posttranslational modification] 226185002799 intermolecular recognition site; other site 226185002800 dimerization interface [polypeptide binding]; other site 226185002801 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226185002802 DNA binding site [nucleotide binding] 226185002803 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226185002804 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226185002805 dimerization interface [polypeptide binding]; other site 226185002806 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226185002807 dimer interface [polypeptide binding]; other site 226185002808 phosphorylation site [posttranslational modification] 226185002809 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226185002810 ATP binding site [chemical binding]; other site 226185002811 Mg2+ binding site [ion binding]; other site 226185002812 G-X-G motif; other site 226185002813 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 226185002814 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 226185002815 Walker A/P-loop; other site 226185002816 ATP binding site [chemical binding]; other site 226185002817 Q-loop/lid; other site 226185002818 ABC transporter signature motif; other site 226185002819 Walker B; other site 226185002820 D-loop; other site 226185002821 H-loop/switch region; other site 226185002822 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 226185002823 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226185002824 dimer interface [polypeptide binding]; other site 226185002825 conserved gate region; other site 226185002826 putative PBP binding loops; other site 226185002827 ABC-ATPase subunit interface; other site 226185002828 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226185002829 dimer interface [polypeptide binding]; other site 226185002830 conserved gate region; other site 226185002831 putative PBP binding loops; other site 226185002832 ABC-ATPase subunit interface; other site 226185002833 AAA domain; Region: AAA_33; pfam13671 226185002834 AAA domain; Region: AAA_18; pfam13238 226185002835 manganese transport protein MntH; Reviewed; Region: PRK00701 226185002836 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 226185002837 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 226185002838 Ligand Binding Site [chemical binding]; other site 226185002839 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 226185002840 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 226185002841 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 226185002842 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 226185002843 peptide binding site [polypeptide binding]; other site 226185002844 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 226185002845 cytosine deaminase; Provisional; Region: PRK05985 226185002846 active site 226185002847 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 226185002848 cytosine deaminase; Provisional; Region: PRK05985 226185002849 active site 226185002850 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 226185002851 maltose O-acetyltransferase; Provisional; Region: PRK10092 226185002852 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 226185002853 active site 226185002854 substrate binding site [chemical binding]; other site 226185002855 trimer interface [polypeptide binding]; other site 226185002856 CoA binding site [chemical binding]; other site 226185002857 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 226185002858 active site 226185002859 catalytic residues [active] 226185002860 galactokinase; Provisional; Region: PRK05322 226185002861 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 226185002862 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 226185002863 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 226185002864 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 226185002865 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 226185002866 NAD binding site [chemical binding]; other site 226185002867 homodimer interface [polypeptide binding]; other site 226185002868 active site 226185002869 substrate binding site [chemical binding]; other site 226185002870 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 226185002871 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 226185002872 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 226185002873 Transcriptional regulators [Transcription]; Region: PurR; COG1609 226185002874 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 226185002875 DNA binding site [nucleotide binding] 226185002876 domain linker motif; other site 226185002877 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 226185002878 putative dimerization interface [polypeptide binding]; other site 226185002879 putative ligand binding site [chemical binding]; other site 226185002880 hypothetical protein; Provisional; Region: PRK06762 226185002881 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 226185002882 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226185002883 Coenzyme A binding pocket [chemical binding]; other site 226185002884 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 226185002885 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 226185002886 active site 226185002887 NTP binding site [chemical binding]; other site 226185002888 metal binding triad [ion binding]; metal-binding site 226185002889 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 226185002890 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 226185002891 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226185002892 Coenzyme A binding pocket [chemical binding]; other site 226185002893 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226185002894 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226185002895 putative substrate translocation pore; other site 226185002896 DNA polymerase IV; Reviewed; Region: PRK03103 226185002897 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 226185002898 active site 226185002899 DNA binding site [nucleotide binding] 226185002900 Protein of unknown function (DUF3016); Region: DUF3016; pfam11454 226185002901 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 226185002902 Ligand Binding Site [chemical binding]; other site 226185002903 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 226185002904 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226185002905 Coenzyme A binding pocket [chemical binding]; other site 226185002906 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 226185002907 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 226185002908 Protein of unknown function (DUF805); Region: DUF805; pfam05656 226185002909 Mga helix-turn-helix domain; Region: Mga; pfam05043 226185002910 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 226185002911 metal ion-dependent adhesion site (MIDAS); other site 226185002912 Cna protein B-type domain; Region: Cna_B; pfam05738 226185002913 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 226185002914 Cna protein B-type domain; Region: Cna_B; pfam05738 226185002915 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 226185002916 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 226185002917 Cna protein B-type domain; Region: Cna_B; pfam05738 226185002918 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 226185002919 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 226185002920 active site 226185002921 catalytic site [active] 226185002922 Domain of unknown function (DUF378); Region: DUF378; pfam04070 226185002923 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 226185002924 Collagen binding domain; Region: Collagen_bind; pfam05737 226185002925 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 226185002926 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 226185002927 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226185002928 Walker A/P-loop; other site 226185002929 ATP binding site [chemical binding]; other site 226185002930 Q-loop/lid; other site 226185002931 ABC transporter signature motif; other site 226185002932 Walker B; other site 226185002933 D-loop; other site 226185002934 H-loop/switch region; other site 226185002935 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226185002936 S-adenosylmethionine binding site [chemical binding]; other site 226185002937 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 226185002938 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 226185002939 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 226185002940 Cysteine-rich domain; Region: CCG; pfam02754 226185002941 Cysteine-rich domain; Region: CCG; pfam02754 226185002942 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 226185002943 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 226185002944 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 226185002945 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 226185002946 Uncharacterized conserved protein [Function unknown]; Region: COG1556 226185002947 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 226185002948 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 226185002949 Catalytic site [active] 226185002950 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 226185002951 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 226185002952 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; cl19914 226185002953 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 226185002954 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 226185002955 Part of AAA domain; Region: AAA_19; pfam13245 226185002956 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 226185002957 Predicted transcriptional regulators [Transcription]; Region: COG1733 226185002958 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 226185002959 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 226185002960 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 226185002961 dimer interface [polypeptide binding]; other site 226185002962 motif 1; other site 226185002963 active site 226185002964 motif 2; other site 226185002965 motif 3; other site 226185002966 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 226185002967 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 226185002968 putative tRNA-binding site [nucleotide binding]; other site 226185002969 B3/4 domain; Region: B3_4; pfam03483 226185002970 tRNA synthetase B5 domain; Region: B5; smart00874 226185002971 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 226185002972 dimer interface [polypeptide binding]; other site 226185002973 motif 1; other site 226185002974 motif 3; other site 226185002975 motif 2; other site 226185002976 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 226185002977 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 226185002978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226185002979 dimer interface [polypeptide binding]; other site 226185002980 conserved gate region; other site 226185002981 putative PBP binding loops; other site 226185002982 ABC-ATPase subunit interface; other site 226185002983 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 226185002984 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226185002985 dimer interface [polypeptide binding]; other site 226185002986 conserved gate region; other site 226185002987 putative PBP binding loops; other site 226185002988 ABC-ATPase subunit interface; other site 226185002989 bifunctional adhesin/ABC transporter aspartate/glutamate-binding protein; Reviewed; Region: PRK11917 226185002990 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 226185002991 substrate binding pocket [chemical binding]; other site 226185002992 membrane-bound complex binding site; other site 226185002993 hinge residues; other site 226185002994 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 226185002995 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 226185002996 Walker A/P-loop; other site 226185002997 ATP binding site [chemical binding]; other site 226185002998 Q-loop/lid; other site 226185002999 ABC transporter signature motif; other site 226185003000 Walker B; other site 226185003001 D-loop; other site 226185003002 H-loop/switch region; other site 226185003003 glutamate racemase; Provisional; Region: PRK00865 226185003004 ribonuclease PH; Reviewed; Region: rph; PRK00173 226185003005 Ribonuclease PH; Region: RNase_PH_bact; cd11362 226185003006 hexamer interface [polypeptide binding]; other site 226185003007 active site 226185003008 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 226185003009 active site 226185003010 dimerization interface [polypeptide binding]; other site 226185003011 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 226185003012 active site 226185003013 metal binding site [ion binding]; metal-binding site 226185003014 homotetramer interface [polypeptide binding]; other site 226185003015 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 226185003016 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 226185003017 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 226185003018 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 226185003019 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 226185003020 active site 226185003021 phosphorylation site [posttranslational modification] 226185003022 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 226185003023 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 226185003024 active site 226185003025 P-loop; other site 226185003026 phosphorylation site [posttranslational modification] 226185003027 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 226185003028 active site 226185003029 dimer interface [polypeptide binding]; other site 226185003030 magnesium binding site [ion binding]; other site 226185003031 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 226185003032 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 226185003033 AP (apurinic/apyrimidinic) site pocket; other site 226185003034 DNA interaction; other site 226185003035 Metal-binding active site; metal-binding site 226185003036 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 226185003037 intersubunit interface [polypeptide binding]; other site 226185003038 active site 226185003039 Zn2+ binding site [ion binding]; other site 226185003040 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 226185003041 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 226185003042 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 226185003043 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 226185003044 putative trimer interface [polypeptide binding]; other site 226185003045 putative CoA binding site [chemical binding]; other site 226185003046 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 226185003047 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 226185003048 metal binding site [ion binding]; metal-binding site 226185003049 putative dimer interface [polypeptide binding]; other site 226185003050 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 226185003051 Mechanosensitive ion channel; Region: MS_channel; pfam00924 226185003052 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 226185003053 active site 226185003054 catalytic tetrad [active] 226185003055 Peptidase C26; Region: Peptidase_C26; pfam07722 226185003056 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 226185003057 catalytic triad [active] 226185003058 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 226185003059 dimer interface [polypeptide binding]; other site 226185003060 active site 226185003061 metal binding site [ion binding]; metal-binding site 226185003062 glutathione binding site [chemical binding]; other site 226185003063 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 226185003064 nudix motif; other site 226185003065 sugar phosphate phosphatase; Provisional; Region: PRK10513 226185003066 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226185003067 active site 226185003068 motif I; other site 226185003069 motif II; other site 226185003070 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 226185003071 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 226185003072 Zn2+ binding site [ion binding]; other site 226185003073 Mg2+ binding site [ion binding]; other site 226185003074 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 226185003075 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 226185003076 DNA-directed RNA polymerase subunit delta; Reviewed; Region: PRK02363 226185003077 CTP synthetase; Validated; Region: pyrG; PRK05380 226185003078 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 226185003079 Catalytic site [active] 226185003080 active site 226185003081 UTP binding site [chemical binding]; other site 226185003082 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 226185003083 active site 226185003084 putative oxyanion hole; other site 226185003085 catalytic triad [active] 226185003086 Transglycosylase; Region: Transgly; pfam00912 226185003087 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 226185003088 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 226185003089 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 226185003090 hypothetical protein; Provisional; Region: PRK13660 226185003091 cell division protein GpsB; Provisional; Region: PRK14127; cl19517 226185003092 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 226185003093 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 226185003094 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 226185003095 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 226185003096 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 226185003097 active site 226185003098 Zn binding site [ion binding]; other site 226185003099 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 226185003100 Helix-turn-helix domain; Region: HTH_36; pfam13730 226185003101 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 226185003102 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 226185003103 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 226185003104 minor groove reading motif; other site 226185003105 helix-hairpin-helix signature motif; other site 226185003106 substrate binding pocket [chemical binding]; other site 226185003107 active site 226185003108 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 226185003109 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226185003110 DNA-binding site [nucleotide binding]; DNA binding site 226185003111 UTRA domain; Region: UTRA; pfam07702 226185003112 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 226185003113 dipeptidase, putative; Region: dipeptidaselike; TIGR01887 226185003114 active site 226185003115 metal binding site [ion binding]; metal-binding site 226185003116 Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635 226185003117 active site 226185003118 dimer interface [polypeptide binding]; other site 226185003119 catalytic nucleophile [active] 226185003120 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 226185003121 active site 226185003122 P-loop; other site 226185003123 phosphorylation site [posttranslational modification] 226185003124 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 226185003125 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB); Region: GRDB; cl19416 226185003126 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 226185003127 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 226185003128 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226185003129 ATP binding site [chemical binding]; other site 226185003130 DEAD_2; Region: DEAD_2; pfam06733 226185003131 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 226185003132 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 226185003133 active site 226185003134 homotetramer interface [polypeptide binding]; other site 226185003135 homodimer interface [polypeptide binding]; other site 226185003136 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 226185003137 Zn2+ binding site [ion binding]; other site 226185003138 Mg2+ binding site [ion binding]; other site 226185003139 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 226185003140 Uncharacterized conserved protein [Function unknown]; Region: COG1284 226185003141 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 226185003142 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 226185003143 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 226185003144 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 226185003145 intersubunit interface [polypeptide binding]; other site 226185003146 active site 226185003147 zinc binding site [ion binding]; other site 226185003148 Na+ binding site [ion binding]; other site 226185003149 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 226185003150 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 226185003151 hinge; other site 226185003152 active site 226185003153 transcription termination factor Rho; Provisional; Region: rho; PRK09376 226185003154 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 226185003155 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 226185003156 RNA binding site [nucleotide binding]; other site 226185003157 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 226185003158 multimer interface [polypeptide binding]; other site 226185003159 Walker A motif; other site 226185003160 ATP binding site [chemical binding]; other site 226185003161 Walker B motif; other site 226185003162 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 226185003163 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; cl19502 226185003164 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 226185003165 glycerol-3-phosphate cytidylyltransferase; Region: g3p_cytidyltrns; TIGR01518 226185003166 active site 226185003167 nucleotide binding site [chemical binding]; other site 226185003168 HIGH motif; other site 226185003169 KMSKS motif; other site 226185003170 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 226185003171 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 226185003172 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 226185003173 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 226185003174 nucleotide binding site [chemical binding]; other site 226185003175 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 226185003176 CsbD-like; Region: CsbD; cl17424 226185003177 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 226185003178 dimer interface [polypeptide binding]; other site 226185003179 FMN binding site [chemical binding]; other site 226185003180 NADPH bind site [chemical binding]; other site 226185003181 S-ribosylhomocysteinase; Provisional; Region: PRK02260 226185003182 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 226185003183 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 226185003184 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 226185003185 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 226185003186 dimer interface [polypeptide binding]; other site 226185003187 active site 226185003188 catalytic residue [active] 226185003189 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 226185003190 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 226185003191 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 226185003192 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 226185003193 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 226185003194 active site 226185003195 metal binding site [ion binding]; metal-binding site 226185003196 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 226185003197 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 226185003198 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 226185003199 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226185003200 active site 226185003201 motif I; other site 226185003202 motif II; other site 226185003203 integral membrane protein TIGR01906; Region: integ_TIGR01906 226185003204 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 226185003205 EDD domain protein, DegV family; Region: DegV; TIGR00762 226185003206 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 226185003207 amphipathic channel; other site 226185003208 Asn-Pro-Ala signature motifs; other site 226185003209 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226185003210 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226185003211 active site 226185003212 phosphorylation site [posttranslational modification] 226185003213 intermolecular recognition site; other site 226185003214 dimerization interface [polypeptide binding]; other site 226185003215 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226185003216 DNA binding site [nucleotide binding] 226185003217 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 226185003218 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226185003219 dimerization interface [polypeptide binding]; other site 226185003220 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 226185003221 putative active site [active] 226185003222 heme pocket [chemical binding]; other site 226185003223 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226185003224 dimer interface [polypeptide binding]; other site 226185003225 phosphorylation site [posttranslational modification] 226185003226 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226185003227 ATP binding site [chemical binding]; other site 226185003228 Mg2+ binding site [ion binding]; other site 226185003229 G-X-G motif; other site 226185003230 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 226185003231 YycH protein; Region: YycH; pfam07435 226185003232 YycH protein; Region: YycI; pfam09648 226185003233 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 226185003234 Predicted permeases [General function prediction only]; Region: COG0701 226185003235 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 226185003236 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 226185003237 Uncharacterized conserved protein [Function unknown]; Region: COG2966 226185003238 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 226185003239 hypothetical protein; Provisional; Region: PRK05473 226185003240 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 226185003241 hypothetical protein; Provisional; Region: PRK13678 226185003242 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 226185003243 Malic enzyme, N-terminal domain; Region: malic; pfam00390 226185003244 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 226185003245 putative NAD(P) binding site [chemical binding]; other site 226185003246 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 226185003247 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 226185003248 PAS domain S-box; Region: sensory_box; TIGR00229 226185003249 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 226185003250 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 226185003251 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226185003252 active site 226185003253 phosphorylation site [posttranslational modification] 226185003254 intermolecular recognition site; other site 226185003255 dimerization interface [polypeptide binding]; other site 226185003256 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 226185003257 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 226185003258 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 226185003259 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 226185003260 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 226185003261 acetolactate synthase; Reviewed; Region: PRK08617 226185003262 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 226185003263 PYR/PP interface [polypeptide binding]; other site 226185003264 dimer interface [polypeptide binding]; other site 226185003265 TPP binding site [chemical binding]; other site 226185003266 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 226185003267 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 226185003268 TPP-binding site [chemical binding]; other site 226185003269 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 226185003270 WxL domain surface cell wall-binding; Region: WxL; pfam13731 226185003271 Src homology 2 (SH2) domain; Region: SH2; cl15255 226185003272 phosphotyrosine binding pocket [polypeptide binding]; other site 226185003273 hydrophobic binding pocket [polypeptide binding]; other site 226185003274 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 226185003275 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226185003276 dimer interface [polypeptide binding]; other site 226185003277 conserved gate region; other site 226185003278 putative PBP binding loops; other site 226185003279 ABC-ATPase subunit interface; other site 226185003280 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 226185003281 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226185003282 dimer interface [polypeptide binding]; other site 226185003283 conserved gate region; other site 226185003284 putative PBP binding loops; other site 226185003285 ABC-ATPase subunit interface; other site 226185003286 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 226185003287 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226185003288 Walker A/P-loop; other site 226185003289 ATP binding site [chemical binding]; other site 226185003290 Q-loop/lid; other site 226185003291 ABC transporter signature motif; other site 226185003292 Walker B; other site 226185003293 D-loop; other site 226185003294 H-loop/switch region; other site 226185003295 TOBE domain; Region: TOBE_2; pfam08402 226185003296 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 226185003297 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 226185003298 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 226185003299 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 226185003300 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 226185003301 active site 226185003302 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 226185003303 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 226185003304 active site 226185003305 putative substrate binding pocket [chemical binding]; other site 226185003306 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226185003307 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226185003308 non-specific DNA binding site [nucleotide binding]; other site 226185003309 salt bridge; other site 226185003310 sequence-specific DNA binding site [nucleotide binding]; other site 226185003311 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 226185003312 Predicted flavoprotein [General function prediction only]; Region: COG0431 226185003313 Predicted flavoprotein [General function prediction only]; Region: COG0431 226185003314 PAS domain; Region: PAS_10; pfam13596 226185003315 Mga helix-turn-helix domain; Region: Mga; pfam05043 226185003316 AP2 domain; Region: AP2; pfam00847 226185003317 DNA binding site [nucleotide binding] 226185003318 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 226185003319 putative active site [active] 226185003320 putative metal binding site [ion binding]; other site 226185003321 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 226185003322 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226185003323 dimer interface [polypeptide binding]; other site 226185003324 conserved gate region; other site 226185003325 putative PBP binding loops; other site 226185003326 ABC-ATPase subunit interface; other site 226185003327 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 226185003328 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226185003329 dimer interface [polypeptide binding]; other site 226185003330 conserved gate region; other site 226185003331 ABC-ATPase subunit interface; other site 226185003332 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 226185003333 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 226185003334 Protein of unknown function, DUF624; Region: DUF624; cl02369 226185003335 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 226185003336 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 226185003337 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 226185003338 putative catalytic site [active] 226185003339 putative metal binding site [ion binding]; other site 226185003340 putative phosphate binding site [ion binding]; other site 226185003341 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 226185003342 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 226185003343 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 226185003344 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 226185003345 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 226185003346 Transcriptional regulators [Transcription]; Region: PurR; COG1609 226185003347 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 226185003348 DNA binding site [nucleotide binding] 226185003349 domain linker motif; other site 226185003350 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 226185003351 dimerization interface [polypeptide binding]; other site 226185003352 ligand binding site [chemical binding]; other site 226185003353 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 226185003354 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226185003355 DNA-binding site [nucleotide binding]; DNA binding site 226185003356 UTRA domain; Region: UTRA; pfam07702 226185003357 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 226185003358 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 226185003359 putative oxidoreductase; Provisional; Region: PRK10206 226185003360 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 226185003361 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 226185003362 Protein of unknown function (DUF441); Region: DUF441; pfam04284 226185003363 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; pfam01521 226185003364 glycoprotein BALF4; Provisional; Region: PHA03231 226185003365 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 226185003366 Domain of unknown function (DUF814); Region: DUF814; pfam05670 226185003367 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 226185003368 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 226185003369 zinc binding site [ion binding]; other site 226185003370 putative ligand binding site [chemical binding]; other site 226185003371 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 226185003372 TM-ABC transporter signature motif; other site 226185003373 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 226185003374 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226185003375 Walker A/P-loop; other site 226185003376 ATP binding site [chemical binding]; other site 226185003377 Q-loop/lid; other site 226185003378 ABC transporter signature motif; other site 226185003379 Walker B; other site 226185003380 D-loop; other site 226185003381 H-loop/switch region; other site 226185003382 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 226185003383 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 226185003384 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226185003385 active site 226185003386 motif I; other site 226185003387 motif II; other site 226185003388 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226185003389 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226185003390 active site 226185003391 phosphorylation site [posttranslational modification] 226185003392 intermolecular recognition site; other site 226185003393 dimerization interface [polypeptide binding]; other site 226185003394 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226185003395 DNA binding site [nucleotide binding] 226185003396 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226185003397 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226185003398 dimerization interface [polypeptide binding]; other site 226185003399 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226185003400 dimer interface [polypeptide binding]; other site 226185003401 phosphorylation site [posttranslational modification] 226185003402 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226185003403 ATP binding site [chemical binding]; other site 226185003404 G-X-G motif; other site 226185003405 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226185003406 Q-loop/lid; other site 226185003407 ABC transporter signature motif; other site 226185003408 Walker B; other site 226185003409 D-loop; other site 226185003410 H-loop/switch region; other site 226185003411 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 226185003412 Sulfatase; Region: Sulfatase; pfam00884 226185003413 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 226185003414 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 226185003415 putative RNA binding site [nucleotide binding]; other site 226185003416 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 226185003417 ribonuclease HIII; Provisional; Region: PRK00996 226185003418 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 226185003419 Bacterial type 2 ribonuclease, HII and HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 226185003420 RNA/DNA hybrid binding site [nucleotide binding]; other site 226185003421 active site 226185003422 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 226185003423 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 226185003424 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 226185003425 Soluble P-type ATPase [General function prediction only]; Region: COG4087 226185003426 Collagen binding domain; Region: Collagen_bind; pfam05737 226185003427 Cna protein B-type domain; Region: Cna_B; pfam05738 226185003428 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 226185003429 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 226185003430 Sm and related proteins; Region: Sm_like; cl00259 226185003431 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 226185003432 putative oligomer interface [polypeptide binding]; other site 226185003433 putative RNA binding site [nucleotide binding]; other site 226185003434 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 226185003435 NusA N-terminal domain; Region: NusA_N; pfam08529 226185003436 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 226185003437 RNA binding site [nucleotide binding]; other site 226185003438 homodimer interface [polypeptide binding]; other site 226185003439 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 226185003440 G-X-X-G motif; other site 226185003441 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 226185003442 G-X-X-G motif; other site 226185003443 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 226185003444 putative RNA binding cleft [nucleotide binding]; other site 226185003445 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 226185003446 translation initiation factor IF-2; Validated; Region: infB; PRK05306 226185003447 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 226185003448 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 226185003449 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 226185003450 G1 box; other site 226185003451 putative GEF interaction site [polypeptide binding]; other site 226185003452 GTP/Mg2+ binding site [chemical binding]; other site 226185003453 Switch I region; other site 226185003454 G2 box; other site 226185003455 G3 box; other site 226185003456 Switch II region; other site 226185003457 G4 box; other site 226185003458 G5 box; other site 226185003459 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 226185003460 Translation-initiation factor 2; Region: IF-2; pfam11987 226185003461 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 226185003462 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 226185003463 PHAGE02, prophage. 226185003464 Domain of unknown function (DUF955); Region: DUF955; cl01076 226185003465 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226185003466 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226185003467 non-specific DNA binding site [nucleotide binding]; other site 226185003468 salt bridge; other site 226185003469 sequence-specific DNA binding site [nucleotide binding]; other site 226185003470 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 226185003471 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 226185003472 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 226185003473 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226185003474 Walker A motif; other site 226185003475 Walker A motif; other site 226185003476 ATP binding site [chemical binding]; other site 226185003477 ATP binding site [chemical binding]; other site 226185003478 Walker B motif; other site 226185003479 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 226185003480 Phage major tail protein 2; Region: Phage_tail_2; cl11463 226185003481 Phage protein; Region: DUF3647; pfam12363 226185003482 Phage-related protein [Function unknown]; Region: COG5412 226185003483 Phage tail protein; Region: Sipho_tail; pfam05709 226185003484 Prophage endopeptidase tail; Region: Prophage_tail; cl19379 226185003485 Holin family; Region: Phage_holin_4; pfam05105 226185003486 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 226185003487 amidase catalytic site [active] 226185003488 Zn binding residues [ion binding]; other site 226185003489 substrate binding site [chemical binding]; other site 226185003490 Bacterial SH3 domain; Region: SH3_5; pfam08460 226185003491 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 226185003492 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 226185003493 active site 226185003494 Riboflavin kinase; Region: Flavokinase; smart00904 226185003495 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226185003496 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 226185003497 Coenzyme A binding pocket [chemical binding]; other site 226185003498 Predicted transcriptional regulators [Transcription]; Region: COG1695 226185003499 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 226185003500 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 226185003501 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 226185003502 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 226185003503 Transcriptional regulator [Transcription]; Region: LysR; COG0583 226185003504 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 226185003505 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 226185003506 dimerization interface [polypeptide binding]; other site 226185003507 Transcriptional regulator [Transcription]; Region: LysR; COG0583 226185003508 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 226185003509 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 226185003510 dimerization interface [polypeptide binding]; other site 226185003511 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 226185003512 magnesium-transporting ATPase; Provisional; Region: PRK15122 226185003513 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 226185003514 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 226185003515 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226185003516 motif II; other site 226185003517 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 226185003518 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 226185003519 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226185003520 FeS/SAM binding site; other site 226185003521 HemN C-terminal domain; Region: HemN_C; pfam06969 226185003522 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 226185003523 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 226185003524 HrcA protein C terminal domain; Region: HrcA; pfam01628 226185003525 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 226185003526 dimer interface [polypeptide binding]; other site 226185003527 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 226185003528 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 226185003529 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 226185003530 nucleotide binding site [chemical binding]; other site 226185003531 NEF interaction site [polypeptide binding]; other site 226185003532 SBD interface [polypeptide binding]; other site 226185003533 chaperone protein DnaJ; Provisional; Region: PRK14276 226185003534 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 226185003535 HSP70 interaction site [polypeptide binding]; other site 226185003536 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 226185003537 substrate binding site [polypeptide binding]; other site 226185003538 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 226185003539 Zn binding sites [ion binding]; other site 226185003540 dimer interface [polypeptide binding]; other site 226185003541 putative protein phosphatase; Region: PHA02239 226185003542 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 226185003543 active site 226185003544 metal binding site [ion binding]; metal-binding site 226185003545 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 226185003546 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 226185003547 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 226185003548 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 226185003549 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 226185003550 RNA binding site [nucleotide binding]; other site 226185003551 hypothetical protein; Provisional; Region: PRK04351 226185003552 aminotransferase AlaT; Validated; Region: PRK09265 226185003553 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226185003554 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226185003555 homodimer interface [polypeptide binding]; other site 226185003556 catalytic residue [active] 226185003557 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226185003558 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226185003559 non-specific DNA binding site [nucleotide binding]; other site 226185003560 salt bridge; other site 226185003561 sequence-specific DNA binding site [nucleotide binding]; other site 226185003562 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 226185003563 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 226185003564 active site 226185003565 dimer interface [polypeptide binding]; other site 226185003566 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 226185003567 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 226185003568 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 226185003569 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 226185003570 Walker A/P-loop; other site 226185003571 ATP binding site [chemical binding]; other site 226185003572 Q-loop/lid; other site 226185003573 ABC transporter signature motif; other site 226185003574 Walker B; other site 226185003575 D-loop; other site 226185003576 H-loop/switch region; other site 226185003577 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 226185003578 FtsX-like permease family; Region: FtsX; pfam02687 226185003579 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 226185003580 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 226185003581 FtsX-like permease family; Region: FtsX; pfam02687 226185003582 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 226185003583 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 226185003584 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 226185003585 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 226185003586 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 226185003587 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 226185003588 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 226185003589 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 226185003590 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 226185003591 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226185003592 DNA-binding site [nucleotide binding]; DNA binding site 226185003593 UTRA domain; Region: UTRA; pfam07702 226185003594 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 226185003595 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 226185003596 ATP binding site [chemical binding]; other site 226185003597 substrate interface [chemical binding]; other site 226185003598 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 226185003599 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226185003600 Walker A/P-loop; other site 226185003601 ATP binding site [chemical binding]; other site 226185003602 Q-loop/lid; other site 226185003603 ABC transporter signature motif; other site 226185003604 Walker B; other site 226185003605 D-loop; other site 226185003606 H-loop/switch region; other site 226185003607 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 226185003608 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 226185003609 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 226185003610 Walker A/P-loop; other site 226185003611 ATP binding site [chemical binding]; other site 226185003612 Q-loop/lid; other site 226185003613 ABC transporter signature motif; other site 226185003614 Walker B; other site 226185003615 D-loop; other site 226185003616 H-loop/switch region; other site 226185003617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 226185003618 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 226185003619 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226185003620 active site 226185003621 phosphorylation site [posttranslational modification] 226185003622 intermolecular recognition site; other site 226185003623 dimerization interface [polypeptide binding]; other site 226185003624 LytTr DNA-binding domain; Region: LytTR; pfam04397 226185003625 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 226185003626 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 226185003627 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 226185003628 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 226185003629 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 226185003630 Walker A/P-loop; other site 226185003631 ATP binding site [chemical binding]; other site 226185003632 Q-loop/lid; other site 226185003633 ABC transporter signature motif; other site 226185003634 Walker B; other site 226185003635 D-loop; other site 226185003636 H-loop/switch region; other site 226185003637 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 226185003638 FtsX-like permease family; Region: FtsX; pfam02687 226185003639 Transcriptional regulators [Transcription]; Region: MarR; COG1846 226185003640 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 226185003641 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 226185003642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226185003643 dimer interface [polypeptide binding]; other site 226185003644 conserved gate region; other site 226185003645 putative PBP binding loops; other site 226185003646 ABC-ATPase subunit interface; other site 226185003647 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 226185003648 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226185003649 dimer interface [polypeptide binding]; other site 226185003650 conserved gate region; other site 226185003651 putative PBP binding loops; other site 226185003652 ABC-ATPase subunit interface; other site 226185003653 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 226185003654 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 226185003655 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 226185003656 homodimer interface [polypeptide binding]; other site 226185003657 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 226185003658 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128 226185003659 active site 226185003660 homodimer interface [polypeptide binding]; other site 226185003661 catalytic site [active] 226185003662 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 226185003663 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 226185003664 Ca binding site [ion binding]; other site 226185003665 active site 226185003666 catalytic site [active] 226185003667 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 226185003668 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 226185003669 Ca binding site [ion binding]; other site 226185003670 active site 226185003671 catalytic site [active] 226185003672 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 226185003673 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 226185003674 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 226185003675 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 226185003676 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 226185003677 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 226185003678 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 226185003679 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 226185003680 tetramer interface [polypeptide binding]; other site 226185003681 TPP-binding site [chemical binding]; other site 226185003682 heterodimer interface [polypeptide binding]; other site 226185003683 phosphorylation loop region [posttranslational modification] 226185003684 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 226185003685 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 226185003686 alpha subunit interface [polypeptide binding]; other site 226185003687 TPP binding site [chemical binding]; other site 226185003688 heterodimer interface [polypeptide binding]; other site 226185003689 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 226185003690 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 226185003691 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 226185003692 E3 interaction surface; other site 226185003693 lipoyl attachment site [posttranslational modification]; other site 226185003694 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 226185003695 E3 interaction surface; other site 226185003696 lipoyl attachment site [posttranslational modification]; other site 226185003697 e3 binding domain; Region: E3_binding; pfam02817 226185003698 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 226185003699 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 226185003700 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 226185003701 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 226185003702 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 226185003703 Sensory domain found in PocR; Region: PocR; pfam10114 226185003704 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226185003705 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226185003706 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226185003707 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 226185003708 dimer interface [polypeptide binding]; other site 226185003709 active site 226185003710 metal binding site [ion binding]; metal-binding site 226185003711 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 226185003712 active pocket/dimerization site; other site 226185003713 active site 226185003714 phosphorylation site [posttranslational modification] 226185003715 dihydroxyacetone kinase, DhaK subunit; Region: dhaK1; TIGR02363 226185003716 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 226185003717 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 226185003718 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 226185003719 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 226185003720 dimer interface [polypeptide binding]; other site 226185003721 active site 226185003722 putative acyltransferase; Provisional; Region: PRK05790 226185003723 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 226185003724 dimer interface [polypeptide binding]; other site 226185003725 active site 226185003726 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 226185003727 homodimer interface [polypeptide binding]; other site 226185003728 catalytic residues [active] 226185003729 NAD binding site [chemical binding]; other site 226185003730 substrate binding pocket [chemical binding]; other site 226185003731 flexible flap; other site 226185003732 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 226185003733 Putative integral membrane protein DUF46; Region: DUF46; cl17511 226185003734 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 226185003735 putative active site [active] 226185003736 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 226185003737 DNA-binding site [nucleotide binding]; DNA binding site 226185003738 RNA-binding motif; other site 226185003739 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226185003740 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226185003741 non-specific DNA binding site [nucleotide binding]; other site 226185003742 salt bridge; other site 226185003743 sequence-specific DNA binding site [nucleotide binding]; other site 226185003744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226185003745 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 226185003746 putative substrate translocation pore; other site 226185003747 metal-dependent hydrolase; Provisional; Region: PRK00685 226185003748 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 226185003749 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 226185003750 DNA-binding site [nucleotide binding]; DNA binding site 226185003751 DRTGG domain; Region: DRTGG; pfam07085 226185003752 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 226185003753 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 226185003754 active site 2 [active] 226185003755 active site 1 [active] 226185003756 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 226185003757 DHH family; Region: DHH; pfam01368 226185003758 DHHA1 domain; Region: DHHA1; pfam02272 226185003759 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 226185003760 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 226185003761 PhnA protein; Region: PhnA; pfam03831 226185003762 VanZ like family; Region: VanZ; pfam04892 226185003763 RDD family; Region: RDD; pfam06271 226185003764 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 226185003765 DEAD-like helicases superfamily; Region: DEXDc; smart00487 226185003766 ATP binding site [chemical binding]; other site 226185003767 Mg++ binding site [ion binding]; other site 226185003768 motif III; other site 226185003769 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226185003770 nucleotide binding region [chemical binding]; other site 226185003771 ATP-binding site [chemical binding]; other site 226185003772 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226185003773 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 226185003774 DNA binding site [nucleotide binding] 226185003775 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 226185003776 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 226185003777 motif 1; other site 226185003778 active site 226185003779 motif 2; other site 226185003780 motif 3; other site 226185003781 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 226185003782 DHHA1 domain; Region: DHHA1; pfam02272 226185003783 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 226185003784 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 226185003785 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 226185003786 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 226185003787 peptidase T-like protein; Region: PepT-like; TIGR01883 226185003788 metal binding site [ion binding]; metal-binding site 226185003789 dimer interface [polypeptide binding]; other site 226185003790 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 226185003791 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 226185003792 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 226185003793 GTP binding site; other site 226185003794 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 226185003795 Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257 226185003796 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 226185003797 putative dimer interface [polypeptide binding]; other site 226185003798 [2Fe-2S] cluster binding site [ion binding]; other site 226185003799 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 226185003800 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 226185003801 SLBB domain; Region: SLBB; pfam10531 226185003802 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 226185003803 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 226185003804 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 226185003805 catalytic loop [active] 226185003806 iron binding site [ion binding]; other site 226185003807 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 226185003808 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 226185003809 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 226185003810 [4Fe-4S] binding site [ion binding]; other site 226185003811 molybdopterin cofactor binding site; other site 226185003812 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 226185003813 molybdopterin cofactor binding site; other site 226185003814 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 226185003815 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 226185003816 dimer interface [polypeptide binding]; other site 226185003817 putative functional site; other site 226185003818 putative MPT binding site; other site 226185003819 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 226185003820 trimer interface [polypeptide binding]; other site 226185003821 dimer interface [polypeptide binding]; other site 226185003822 putative active site [active] 226185003823 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 226185003824 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226185003825 FeS/SAM binding site; other site 226185003826 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 226185003827 MOSC domain; Region: MOSC; pfam03473 226185003828 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 226185003829 MPT binding site; other site 226185003830 trimer interface [polypeptide binding]; other site 226185003831 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 226185003832 putative MPT binding site; other site 226185003833 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 226185003834 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 226185003835 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226185003836 dimer interface [polypeptide binding]; other site 226185003837 conserved gate region; other site 226185003838 putative PBP binding loops; other site 226185003839 ABC-ATPase subunit interface; other site 226185003840 ATP-binding cassette domain of the molybdenum transport system; Region: ABC_ModC_molybdenum_transporter; cd03297 226185003841 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 226185003842 Walker A/P-loop; other site 226185003843 ATP binding site [chemical binding]; other site 226185003844 Q-loop/lid; other site 226185003845 ABC transporter signature motif; other site 226185003846 Walker B; other site 226185003847 D-loop; other site 226185003848 H-loop/switch region; other site 226185003849 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 226185003850 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 226185003851 metal-binding site [ion binding] 226185003852 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 226185003853 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 226185003854 Cell division protein ZapA; Region: ZapA; cl01146 226185003855 Colicin V production protein; Region: Colicin_V; pfam02674 226185003856 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 226185003857 MutS domain III; Region: MutS_III; pfam05192 226185003858 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 226185003859 Walker A/P-loop; other site 226185003860 ATP binding site [chemical binding]; other site 226185003861 Q-loop/lid; other site 226185003862 ABC transporter signature motif; other site 226185003863 Walker B; other site 226185003864 D-loop; other site 226185003865 H-loop/switch region; other site 226185003866 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 226185003867 Smr domain; Region: Smr; pfam01713 226185003868 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 226185003869 catalytic residues [active] 226185003870 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 226185003871 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 226185003872 GIY-YIG motif/motif A; other site 226185003873 active site 226185003874 catalytic site [active] 226185003875 putative DNA binding site [nucleotide binding]; other site 226185003876 metal binding site [ion binding]; metal-binding site 226185003877 UvrB/uvrC motif; Region: UVR; pfam02151 226185003878 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 226185003879 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 226185003880 Protein of unknown function (DUF3884); Region: DUF3884; pfam13024 226185003881 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 226185003882 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226185003883 Walker A/P-loop; other site 226185003884 ATP binding site [chemical binding]; other site 226185003885 Q-loop/lid; other site 226185003886 ABC transporter signature motif; other site 226185003887 Walker B; other site 226185003888 D-loop; other site 226185003889 H-loop/switch region; other site 226185003890 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 226185003891 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 226185003892 Transcriptional regulators [Transcription]; Region: PurR; COG1609 226185003893 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 226185003894 DNA binding site [nucleotide binding] 226185003895 domain linker motif; other site 226185003896 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 226185003897 putative dimerization interface [polypeptide binding]; other site 226185003898 putative ligand binding site [chemical binding]; other site 226185003899 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 226185003900 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 226185003901 NAD binding site [chemical binding]; other site 226185003902 sugar binding site [chemical binding]; other site 226185003903 divalent metal binding site [ion binding]; other site 226185003904 tetramer (dimer of dimers) interface [polypeptide binding]; other site 226185003905 dimer interface [polypeptide binding]; other site 226185003906 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 226185003907 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 226185003908 ABC transporter; Region: ABC_tran_2; pfam12848 226185003909 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 226185003910 HI0933-like protein; Region: HI0933_like; pfam03486 226185003911 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 226185003912 glutamate dehydrogenase; Provisional; Region: PRK09414 226185003913 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 226185003914 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 226185003915 NAD(P) binding site [chemical binding]; other site 226185003916 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 226185003917 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 226185003918 active site 226185003919 dimer interface [polypeptide binding]; other site 226185003920 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 226185003921 dimer interface [polypeptide binding]; other site 226185003922 active site 226185003923 PHAGE03, prophage. 226185003924 AP2-like DNA-binding integrase domain; Region: Integrase_AP2; pfam14657 226185003925 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 226185003926 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 226185003927 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 226185003928 active site 226185003929 DNA binding site [nucleotide binding] 226185003930 Int/Topo IB signature motif; other site 226185003931 Domain of unknown function (DUF955); Region: DUF955; cl01076 226185003932 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226185003933 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226185003934 non-specific DNA binding site [nucleotide binding]; other site 226185003935 salt bridge; other site 226185003936 sequence-specific DNA binding site [nucleotide binding]; other site 226185003937 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226185003938 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226185003939 non-specific DNA binding site [nucleotide binding]; other site 226185003940 salt bridge; other site 226185003941 sequence-specific DNA binding site [nucleotide binding]; other site 226185003942 Helix-turn-helix domain; Region: HTH_17; pfam12728 226185003943 AAA domain; Region: AAA_23; pfam13476 226185003944 Walker A/P-loop; other site 226185003945 ATP binding site [chemical binding]; other site 226185003946 Syntaxin; Region: Syntaxin; cl00143 226185003947 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 226185003948 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 226185003949 Helix-turn-helix domain; Region: HTH_36; pfam13730 226185003950 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 226185003951 Recombination protein U; Region: RecU; cl01314 226185003952 YsaB-like lipoprotein; Region: YsaB; pfam13983 226185003953 YopX protein; Region: YopX; pfam09643 226185003954 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 226185003955 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 226185003956 Methylmalonic aciduria and homocystinuria type C protein and similar proteins; Region: MMACHC-like; cd12959 226185003957 positive control sigma-like factor; Validated; Region: PRK06930 226185003958 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 226185003959 DNA binding residues [nucleotide binding] 226185003960 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 226185003961 ParB-like nuclease domain; Region: ParBc; pfam02195 226185003962 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 226185003963 Terminase small subunit; Region: Terminase_2; cl01513 226185003964 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 226185003965 Terminase-like family; Region: Terminase_6; pfam03237 226185003966 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 226185003967 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 226185003968 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 226185003969 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 226185003970 active site 226185003971 conformational flexibility of ligand binding pocket; other site 226185003972 ADP-ribosylating toxin turn-turn motif; other site 226185003973 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 226185003974 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; cl19842 226185003975 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 226185003976 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 226185003977 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 226185003978 Protein of unknown function (DUF3277); Region: DUF3277; pfam11681 226185003979 Phage-related tail protein [Function unknown]; Region: COG5283 226185003980 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 226185003981 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 226185003982 Peptidase family M23; Region: Peptidase_M23; pfam01551 226185003983 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 226185003984 N-acetyl-D-glucosamine binding site [chemical binding]; other site 226185003985 catalytic residue [active] 226185003986 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 226185003987 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 226185003988 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 226185003989 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 226185003990 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 226185003991 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 226185003992 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 226185003993 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 226185003994 amidase catalytic site [active] 226185003995 Zn binding residues [ion binding]; other site 226185003996 substrate binding site [chemical binding]; other site 226185003997 Bacterial SH3 domain; Region: SH3_5; pfam08460 226185003998 flavoprotein NrdI; Provisional; Region: PRK02551 226185003999 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 226185004000 V-type ATP synthase subunit I; Validated; Region: PRK05771 226185004001 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 226185004002 V-type ATP synthase subunit K; Validated; Region: PRK06558 226185004003 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 226185004004 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 226185004005 phosphodiesterase; Provisional; Region: PRK12704 226185004006 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 226185004007 ATP synthase (C/AC39) subunit; Region: vATP-synt_AC39; cl00660 226185004008 V-type ATP synthase subunit F; Provisional; Region: PRK01395 226185004009 V-type ATP synthase subunit A; Provisional; Region: PRK04192 226185004010 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 226185004011 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 226185004012 Walker A motif/ATP binding site; other site 226185004013 Walker B motif; other site 226185004014 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 226185004015 V-type ATP synthase subunit B; Provisional; Region: PRK04196 226185004016 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 226185004017 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 226185004018 Walker A motif homologous position; other site 226185004019 Walker B motif; other site 226185004020 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 226185004021 V-type ATP synthase subunit D; Reviewed; Region: PRK00373 226185004022 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 226185004023 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; cl19619 226185004024 diaminopimelate decarboxylase; Region: lysA; TIGR01048 226185004025 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 226185004026 active site 226185004027 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 226185004028 substrate binding site [chemical binding]; other site 226185004029 catalytic residues [active] 226185004030 dimer interface [polypeptide binding]; other site 226185004031 Putative lysophospholipase; Region: Hydrolase_4; cl19140 226185004032 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 226185004033 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 226185004034 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 226185004035 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 226185004036 active site 226185004037 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 226185004038 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 226185004039 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 226185004040 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 226185004041 peptide binding site [polypeptide binding]; other site 226185004042 transcriptional antiterminator BglG; Provisional; Region: PRK09772 226185004043 CAT RNA binding domain; Region: CAT_RBD; smart01061 226185004044 PRD domain; Region: PRD; pfam00874 226185004045 PRD domain; Region: PRD; pfam00874 226185004046 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 226185004047 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 226185004048 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 226185004049 active site turn [active] 226185004050 phosphorylation site [posttranslational modification] 226185004051 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 226185004052 HPr interaction site; other site 226185004053 glycerol kinase (GK) interaction site [polypeptide binding]; other site 226185004054 active site 226185004055 phosphorylation site [posttranslational modification] 226185004056 Lysozyme-like; Region: Lysozyme_like; pfam13702 226185004057 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 226185004058 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 226185004059 hypothetical protein; Provisional; Region: PRK09716 226185004060 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226185004061 motif II; other site 226185004062 DNA primase, catalytic core; Region: dnaG; TIGR01391 226185004063 CHC2 zinc finger; Region: zf-CHC2; pfam01807 226185004064 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 226185004065 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 226185004066 active site 226185004067 metal binding site [ion binding]; metal-binding site 226185004068 interdomain interaction site; other site 226185004069 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 226185004070 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 226185004071 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 226185004072 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 226185004073 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226185004074 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 226185004075 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226185004076 DNA binding residues [nucleotide binding] 226185004077 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 226185004078 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 226185004079 S1 domain; Region: S1_2; pfam13509 226185004080 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 226185004081 metal binding site 2 [ion binding]; metal-binding site 226185004082 putative DNA binding helix; other site 226185004083 metal binding site 1 [ion binding]; metal-binding site 226185004084 dimer interface [polypeptide binding]; other site 226185004085 structural Zn2+ binding site [ion binding]; other site 226185004086 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 226185004087 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 226185004088 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 226185004089 GTPase CgtA; Reviewed; Region: obgE; PRK12297 226185004090 GTP1/OBG; Region: GTP1_OBG; pfam01018 226185004091 Obg GTPase; Region: Obg; cd01898 226185004092 G1 box; other site 226185004093 GTP/Mg2+ binding site [chemical binding]; other site 226185004094 Switch I region; other site 226185004095 G2 box; other site 226185004096 G3 box; other site 226185004097 Switch II region; other site 226185004098 G4 box; other site 226185004099 G5 box; other site 226185004100 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 226185004101 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 226185004102 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226185004103 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 226185004104 WHG domain; Region: WHG; pfam13305 226185004105 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 226185004106 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 226185004107 active site 226185004108 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 226185004109 Putative lysophospholipase; Region: Hydrolase_4; cl19140 226185004110 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 226185004111 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 226185004112 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 226185004113 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 226185004114 active site 226185004115 Int/Topo IB signature motif; other site 226185004116 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 226185004117 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 226185004118 Predicted membrane protein [Function unknown]; Region: COG3601 226185004119 Predicted membrane protein [Function unknown]; Region: COG4640 226185004120 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 226185004121 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 226185004122 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 226185004123 Helix-turn-helix domain; Region: HTH_40; pfam14493 226185004124 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 226185004125 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226185004126 ATP binding site [chemical binding]; other site 226185004127 putative Mg++ binding site [ion binding]; other site 226185004128 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226185004129 nucleotide binding region [chemical binding]; other site 226185004130 ATP-binding site [chemical binding]; other site 226185004131 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 226185004132 cytidylate kinase; Provisional; Region: cmk; PRK00023 226185004133 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 226185004134 AAA domain; Region: AAA_17; cl19128 226185004135 CMP-binding site; other site 226185004136 The sites determining sugar specificity; other site 226185004137 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 226185004138 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 226185004139 RNA binding site [nucleotide binding]; other site 226185004140 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 226185004141 RNA binding site [nucleotide binding]; other site 226185004142 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 226185004143 RNA binding site [nucleotide binding]; other site 226185004144 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 226185004145 RNA binding site [nucleotide binding]; other site 226185004146 GTP-binding protein Der; Reviewed; Region: PRK00093 226185004147 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 226185004148 G1 box; other site 226185004149 GTP/Mg2+ binding site [chemical binding]; other site 226185004150 Switch I region; other site 226185004151 G2 box; other site 226185004152 Switch II region; other site 226185004153 G3 box; other site 226185004154 G4 box; other site 226185004155 G5 box; other site 226185004156 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 226185004157 G1 box; other site 226185004158 GTP/Mg2+ binding site [chemical binding]; other site 226185004159 Switch I region; other site 226185004160 G2 box; other site 226185004161 G3 box; other site 226185004162 Switch II region; other site 226185004163 G4 box; other site 226185004164 G5 box; other site 226185004165 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 226185004166 histone-like DNA-binding protein HU; Region: HU; cd13831 226185004167 dimer interface [polypeptide binding]; other site 226185004168 DNA binding site [nucleotide binding] 226185004169 Tetratricopeptide repeat; Region: TPR_19; pfam14559 226185004170 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226185004171 TPR motif; other site 226185004172 binding surface 226185004173 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226185004174 TPR motif; other site 226185004175 binding surface 226185004176 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226185004177 TPR motif; other site 226185004178 binding surface 226185004179 Tetratricopeptide repeat; Region: TPR_19; pfam14559 226185004180 hypothetical protein; Provisional; Region: PRK03636 226185004181 UPF0302 domain; Region: UPF0302; pfam08864 226185004182 IDEAL domain; Region: IDEAL; pfam08858 226185004183 Uncharacterized conserved protein [Function unknown]; Region: COG1284 226185004184 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 226185004185 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 226185004186 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 226185004187 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 226185004188 homodimer interface [polypeptide binding]; other site 226185004189 metal binding site [ion binding]; metal-binding site 226185004190 dihydrodipicolinate reductase; Provisional; Region: PRK00048 226185004191 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 226185004192 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 226185004193 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 226185004194 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 226185004195 active site 226185004196 NTP binding site [chemical binding]; other site 226185004197 metal binding triad [ion binding]; metal-binding site 226185004198 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 226185004199 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 226185004200 Predicted thioesterase [General function prediction only]; Region: COG5496 226185004201 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 226185004202 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 226185004203 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 226185004204 shikimate binding site; other site 226185004205 NAD(P) binding site [chemical binding]; other site 226185004206 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 226185004207 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 226185004208 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 226185004209 active site 226185004210 dimer interface [polypeptide binding]; other site 226185004211 metal binding site [ion binding]; metal-binding site 226185004212 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 226185004213 Tetramer interface [polypeptide binding]; other site 226185004214 active site 226185004215 FMN-binding site [chemical binding]; other site 226185004216 prephenate dehydrogenase; Validated; Region: PRK08507 226185004217 prephenate dehydrogenase; Validated; Region: PRK06545 226185004218 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 226185004219 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 226185004220 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 226185004221 hinge; other site 226185004222 active site 226185004223 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 226185004224 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 226185004225 ADP binding site [chemical binding]; other site 226185004226 magnesium binding site [ion binding]; other site 226185004227 putative shikimate binding site; other site 226185004228 prephenate dehydratase; Provisional; Region: PRK11898 226185004229 Prephenate dehydratase; Region: PDT; pfam00800 226185004230 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 226185004231 putative L-Phe binding site [chemical binding]; other site 226185004232 Transcriptional regulator [Transcription]; Region: LytR; COG1316 226185004233 EDD domain protein, DegV family; Region: DegV; TIGR00762 226185004234 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 226185004235 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 226185004236 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 226185004237 ABC transporter; Region: ABC_tran_2; pfam12848 226185004238 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 226185004239 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 226185004240 dimerization interface [polypeptide binding]; other site 226185004241 active site 226185004242 Thioredoxin; Region: Thioredoxin_5; pfam13743 226185004243 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 226185004244 folate binding site [chemical binding]; other site 226185004245 NADP+ binding site [chemical binding]; other site 226185004246 epoxyqueuosine reductase; Region: TIGR00276 226185004247 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 226185004248 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 226185004249 HEAT-like repeat; Region: HEAT_EZ; pfam13513 226185004250 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226185004251 putative DNA binding site [nucleotide binding]; other site 226185004252 LexA repressor; Validated; Region: PRK00215 226185004253 putative Zn2+ binding site [ion binding]; other site 226185004254 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 226185004255 Catalytic site [active] 226185004256 hypothetical protein; Provisional; Region: PRK02539 226185004257 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226185004258 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 226185004259 putative substrate translocation pore; other site 226185004260 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 226185004261 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 226185004262 cysteine synthase; Region: PLN02565 226185004263 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 226185004264 dimer interface [polypeptide binding]; other site 226185004265 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226185004266 catalytic residue [active] 226185004267 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 226185004268 metal binding site 2 [ion binding]; metal-binding site 226185004269 putative DNA binding helix; other site 226185004270 metal binding site 1 [ion binding]; metal-binding site 226185004271 dimer interface [polypeptide binding]; other site 226185004272 structural Zn2+ binding site [ion binding]; other site 226185004273 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 226185004274 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 226185004275 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 226185004276 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 226185004277 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 226185004278 nudix motif; other site 226185004279 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226185004280 Coenzyme A binding pocket [chemical binding]; other site 226185004281 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 226185004282 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226185004283 Coenzyme A binding pocket [chemical binding]; other site 226185004284 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 226185004285 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226185004286 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226185004287 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226185004288 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 226185004289 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 226185004290 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226185004291 Walker A/P-loop; other site 226185004292 ATP binding site [chemical binding]; other site 226185004293 Q-loop/lid; other site 226185004294 ABC transporter signature motif; other site 226185004295 Walker B; other site 226185004296 D-loop; other site 226185004297 H-loop/switch region; other site 226185004298 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 226185004299 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 226185004300 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226185004301 Walker A/P-loop; other site 226185004302 ATP binding site [chemical binding]; other site 226185004303 Q-loop/lid; other site 226185004304 ABC transporter signature motif; other site 226185004305 Walker B; other site 226185004306 D-loop; other site 226185004307 H-loop/switch region; other site 226185004308 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 226185004309 nudix motif; other site 226185004310 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 226185004311 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 226185004312 tetramer interface [polypeptide binding]; other site 226185004313 heme binding pocket [chemical binding]; other site 226185004314 NADPH binding site [chemical binding]; other site 226185004315 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 226185004316 DNA photolyase; Region: DNA_photolyase; pfam00875 226185004317 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 226185004318 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226185004319 non-specific DNA binding site [nucleotide binding]; other site 226185004320 salt bridge; other site 226185004321 sequence-specific DNA binding site [nucleotide binding]; other site 226185004322 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226185004323 binding surface 226185004324 TPR motif; other site 226185004325 Tetratricopeptide repeat; Region: TPR_12; pfam13424 226185004326 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 226185004327 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 226185004328 active site turn [active] 226185004329 phosphorylation site [posttranslational modification] 226185004330 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 226185004331 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 226185004332 HPr interaction site; other site 226185004333 glycerol kinase (GK) interaction site [polypeptide binding]; other site 226185004334 active site 226185004335 phosphorylation site [posttranslational modification] 226185004336 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 226185004337 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 226185004338 Ca binding site [ion binding]; other site 226185004339 active site 226185004340 catalytic site [active] 226185004341 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 226185004342 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 226185004343 substrate binding [chemical binding]; other site 226185004344 active site 226185004345 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 226185004346 Transcriptional regulators [Transcription]; Region: PurR; COG1609 226185004347 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 226185004348 DNA binding site [nucleotide binding] 226185004349 domain linker motif; other site 226185004350 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 226185004351 dimerization interface [polypeptide binding]; other site 226185004352 ligand binding site [chemical binding]; other site 226185004353 sodium binding site [ion binding]; other site 226185004354 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 226185004355 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 226185004356 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 226185004357 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 226185004358 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 226185004359 putative active site [active] 226185004360 catalytic site [active] 226185004361 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 226185004362 putative active site [active] 226185004363 catalytic site [active] 226185004364 hypothetical protein; Provisional; Region: PRK04164 226185004365 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 226185004366 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 226185004367 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 226185004368 DHH family; Region: DHH; pfam01368 226185004369 DHHA2 domain; Region: DHHA2; pfam02833 226185004370 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 226185004371 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226185004372 FeS/SAM binding site; other site 226185004373 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 226185004374 Pyruvate formate lyase 1; Region: PFL1; cd01678 226185004375 coenzyme A binding site [chemical binding]; other site 226185004376 active site 226185004377 catalytic residues [active] 226185004378 glycine loop; other site 226185004379 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 226185004380 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 226185004381 CAP-like domain; other site 226185004382 active site 226185004383 primary dimer interface [polypeptide binding]; other site 226185004384 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 226185004385 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 226185004386 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 226185004387 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226185004388 ATP binding site [chemical binding]; other site 226185004389 Mg2+ binding site [ion binding]; other site 226185004390 G-X-G motif; other site 226185004391 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 226185004392 anchoring element; other site 226185004393 dimer interface [polypeptide binding]; other site 226185004394 ATP binding site [chemical binding]; other site 226185004395 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 226185004396 active site 226185004397 metal binding site [ion binding]; metal-binding site 226185004398 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 226185004399 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 226185004400 Cupin domain; Region: Cupin_2; cl17218 226185004401 ethanolamine utilization protein EutH; Provisional; Region: PRK15086 226185004402 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 226185004403 Hexamer/Pentamer interface [polypeptide binding]; other site 226185004404 central pore; other site 226185004405 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 226185004406 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 226185004407 Propanediol utilisation protein PduL; Region: PduL; pfam06130 226185004408 Propanediol utilisation protein PduL; Region: PduL; pfam06130 226185004409 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 226185004410 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 226185004411 Hexamer interface [polypeptide binding]; other site 226185004412 Putative hexagonal pore residue; other site 226185004413 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 226185004414 putative catalytic cysteine [active] 226185004415 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 226185004416 Hexamer interface [polypeptide binding]; other site 226185004417 Hexagonal pore residue; other site 226185004418 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 226185004419 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 226185004420 putative hexamer interface [polypeptide binding]; other site 226185004421 putative hexagonal pore; other site 226185004422 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 226185004423 putative hexamer interface [polypeptide binding]; other site 226185004424 putative hexagonal pore; other site 226185004425 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 226185004426 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 226185004427 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 226185004428 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 226185004429 Histidine kinase; Region: HisKA_2; pfam07568 226185004430 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226185004431 ATP binding site [chemical binding]; other site 226185004432 Mg2+ binding site [ion binding]; other site 226185004433 G-X-G motif; other site 226185004434 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 226185004435 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226185004436 active site 226185004437 phosphorylation site [posttranslational modification] 226185004438 intermolecular recognition site; other site 226185004439 dimerization interface [polypeptide binding]; other site 226185004440 ANTAR domain; Region: ANTAR; pfam03861 226185004441 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 226185004442 putative hexamer interface [polypeptide binding]; other site 226185004443 putative hexagonal pore; other site 226185004444 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 226185004445 putative active site [active] 226185004446 metal binding site [ion binding]; metal-binding site 226185004447 ATP:cob(I)alamin adenosyltransferase; Region: PduO_Nterm; TIGR00636 226185004448 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 226185004449 G1 box; other site 226185004450 GTP/Mg2+ binding site [chemical binding]; other site 226185004451 G2 box; other site 226185004452 Switch I region; other site 226185004453 G3 box; other site 226185004454 Switch II region; other site 226185004455 G4 box; other site 226185004456 G5 box; other site 226185004457 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 226185004458 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 226185004459 Walker A/P-loop; other site 226185004460 ATP binding site [chemical binding]; other site 226185004461 Q-loop/lid; other site 226185004462 ABC transporter signature motif; other site 226185004463 Walker B; other site 226185004464 D-loop; other site 226185004465 H-loop/switch region; other site 226185004466 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 226185004467 ABC-ATPase subunit interface; other site 226185004468 dimer interface [polypeptide binding]; other site 226185004469 putative PBP binding regions; other site 226185004470 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 226185004471 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 226185004472 putative binding site residues; other site 226185004473 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 226185004474 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 226185004475 active site 226185004476 catalytic residues [active] 226185004477 CodY GAF-like domain; Region: CodY; pfam06018 226185004478 GTP-sensing transcriptional pleiotropic repressor CodY; Region: codY_Gpos; TIGR02787 226185004479 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226185004480 putative DNA binding site [nucleotide binding]; other site 226185004481 putative Zn2+ binding site [ion binding]; other site 226185004482 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 226185004483 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226185004484 Walker A motif; other site 226185004485 ATP binding site [chemical binding]; other site 226185004486 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 226185004487 Walker B motif; other site 226185004488 arginine finger; other site 226185004489 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 226185004490 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 226185004491 active site 226185004492 HslU subunit interaction site [polypeptide binding]; other site 226185004493 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 226185004494 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 226185004495 active site 226185004496 DNA binding site [nucleotide binding] 226185004497 Int/Topo IB signature motif; other site 226185004498 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 226185004499 Glucose inhibited division protein A; Region: GIDA; pfam01134 226185004500 DNA topoisomerase I; Validated; Region: PRK05582 226185004501 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 226185004502 active site 226185004503 interdomain interaction site; other site 226185004504 putative metal-binding site [ion binding]; other site 226185004505 nucleotide binding site [chemical binding]; other site 226185004506 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 226185004507 domain I; other site 226185004508 DNA binding groove [nucleotide binding] 226185004509 phosphate binding site [ion binding]; other site 226185004510 domain II; other site 226185004511 domain III; other site 226185004512 nucleotide binding site [chemical binding]; other site 226185004513 catalytic site [active] 226185004514 domain IV; other site 226185004515 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 226185004516 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 226185004517 CAAX protease self-immunity; Region: Abi; pfam02517 226185004518 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 226185004519 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 226185004520 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 226185004521 RNA/DNA hybrid binding site [nucleotide binding]; other site 226185004522 active site 226185004523 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 226185004524 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 226185004525 GTP/Mg2+ binding site [chemical binding]; other site 226185004526 G4 box; other site 226185004527 G5 box; other site 226185004528 G1 box; other site 226185004529 Switch I region; other site 226185004530 G2 box; other site 226185004531 G3 box; other site 226185004532 Switch II region; other site 226185004533 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 226185004534 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 226185004535 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 226185004536 Transcriptional regulator [Transcription]; Region: LysR; COG0583 226185004537 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 226185004538 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 226185004539 dimerization interface [polypeptide binding]; other site 226185004540 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 226185004541 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 226185004542 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 226185004543 E3 interaction surface; other site 226185004544 lipoyl attachment site [posttranslational modification]; other site 226185004545 e3 binding domain; Region: E3_binding; pfam02817 226185004546 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 226185004547 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 226185004548 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 226185004549 alpha subunit interface [polypeptide binding]; other site 226185004550 TPP binding site [chemical binding]; other site 226185004551 heterodimer interface [polypeptide binding]; other site 226185004552 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 226185004553 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 226185004554 tetramer interface [polypeptide binding]; other site 226185004555 TPP-binding site [chemical binding]; other site 226185004556 heterodimer interface [polypeptide binding]; other site 226185004557 phosphorylation loop region [posttranslational modification] 226185004558 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 226185004559 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 226185004560 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 226185004561 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 226185004562 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 226185004563 nucleotide binding site [chemical binding]; other site 226185004564 Acetokinase family; Region: Acetate_kinase; cl17229 226185004565 branched-chain phosphotransacylase; Region: branched_ptb; TIGR02709 226185004566 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 226185004567 putative active site [active] 226185004568 TraX protein; Region: TraX; cl05434 226185004569 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 226185004570 classical (c) SDRs; Region: SDR_c; cd05233 226185004571 NAD(P) binding site [chemical binding]; other site 226185004572 active site 226185004573 Transcriptional regulators [Transcription]; Region: MarR; COG1846 226185004574 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 226185004575 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 226185004576 Zn binding site [ion binding]; other site 226185004577 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 226185004578 Zn binding site [ion binding]; other site 226185004579 Predicted esterase [General function prediction only]; Region: COG0400 226185004580 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 226185004581 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 226185004582 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 226185004583 putative NAD(P) binding site [chemical binding]; other site 226185004584 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 226185004585 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 226185004586 FtsX-like permease family; Region: FtsX; pfam02687 226185004587 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 226185004588 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 226185004589 Walker A/P-loop; other site 226185004590 ATP binding site [chemical binding]; other site 226185004591 Q-loop/lid; other site 226185004592 ABC transporter signature motif; other site 226185004593 Walker B; other site 226185004594 D-loop; other site 226185004595 H-loop/switch region; other site 226185004596 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 226185004597 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 226185004598 Walker A/P-loop; other site 226185004599 ATP binding site [chemical binding]; other site 226185004600 Q-loop/lid; other site 226185004601 ABC transporter signature motif; other site 226185004602 Walker B; other site 226185004603 D-loop; other site 226185004604 H-loop/switch region; other site 226185004605 Predicted transcriptional regulators [Transcription]; Region: COG1725 226185004606 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226185004607 DNA-binding site [nucleotide binding]; DNA binding site 226185004608 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 226185004609 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 226185004610 Catalytic site [active] 226185004611 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 226185004612 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 226185004613 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 226185004614 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 226185004615 protein binding site [polypeptide binding]; other site 226185004616 Catalytic dyad [active] 226185004617 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 226185004618 hypothetical protein; Provisional; Region: PRK13672 226185004619 methionine sulfoxide reductase A; Provisional; Region: PRK14054 226185004620 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 226185004621 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 226185004622 active site 226185004623 catalytic triad [active] 226185004624 oxyanion hole [active] 226185004625 EDD domain protein, DegV family; Region: DegV; TIGR00762 226185004626 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 226185004627 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 226185004628 active site 226185004629 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 226185004630 DHH family; Region: DHH; pfam01368 226185004631 DHHA1 domain; Region: DHHA1; pfam02272 226185004632 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 226185004633 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 226185004634 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 226185004635 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226185004636 NAD(P) binding site [chemical binding]; other site 226185004637 active site 226185004638 ribonuclease Z; Region: RNase_Z; TIGR02651 226185004639 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 226185004640 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 226185004641 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 226185004642 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 226185004643 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226185004644 Coenzyme A binding pocket [chemical binding]; other site 226185004645 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 226185004646 Predicted flavoprotein [General function prediction only]; Region: COG0431 226185004647 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 226185004648 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 226185004649 DNA binding residues [nucleotide binding] 226185004650 dimer interface [polypeptide binding]; other site 226185004651 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 226185004652 signal recognition particle protein; Provisional; Region: PRK10867 226185004653 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 226185004654 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 226185004655 P loop; other site 226185004656 GTP binding site [chemical binding]; other site 226185004657 Signal peptide binding domain; Region: SRP_SPB; pfam02978 226185004658 putative DNA-binding protein; Validated; Region: PRK00118 226185004659 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 226185004660 Uncharacterized conserved protein [Function unknown]; Region: COG1683 226185004661 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226185004662 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226185004663 active site 226185004664 phosphorylation site [posttranslational modification] 226185004665 intermolecular recognition site; other site 226185004666 dimerization interface [polypeptide binding]; other site 226185004667 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226185004668 DNA binding site [nucleotide binding] 226185004669 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 226185004670 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 226185004671 putative active site [active] 226185004672 heme pocket [chemical binding]; other site 226185004673 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226185004674 dimer interface [polypeptide binding]; other site 226185004675 phosphorylation site [posttranslational modification] 226185004676 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226185004677 ATP binding site [chemical binding]; other site 226185004678 Mg2+ binding site [ion binding]; other site 226185004679 G-X-G motif; other site 226185004680 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 226185004681 aminotransferase A; Validated; Region: PRK07683 226185004682 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226185004683 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226185004684 homodimer interface [polypeptide binding]; other site 226185004685 catalytic residue [active] 226185004686 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 226185004687 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 226185004688 active site 226185004689 metal binding site [ion binding]; metal-binding site 226185004690 homodimer interface [polypeptide binding]; other site 226185004691 catalytic site [active] 226185004692 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 226185004693 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 226185004694 Uncharacterized conserved protein [Function unknown]; Region: COG3538 226185004695 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 226185004696 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226185004697 DNA-binding site [nucleotide binding]; DNA binding site 226185004698 Transcriptional regulators [Transcription]; Region: PurR; COG1609 226185004699 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 226185004700 ligand binding site [chemical binding]; other site 226185004701 dimerization interface [polypeptide binding]; other site 226185004702 Transcriptional regulator [Transcription]; Region: LysR; COG0583 226185004703 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 226185004704 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 226185004705 dimerization interface [polypeptide binding]; other site 226185004706 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 226185004707 active site 226185004708 zinc binding site [ion binding]; other site 226185004709 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 226185004710 active site 226185004711 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 226185004712 active site 226185004713 dimer interface [polypeptide binding]; other site 226185004714 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 226185004715 heterodimer interface [polypeptide binding]; other site 226185004716 active site 226185004717 FMN binding site [chemical binding]; other site 226185004718 homodimer interface [polypeptide binding]; other site 226185004719 substrate binding site [chemical binding]; other site 226185004720 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 226185004721 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 226185004722 FAD binding pocket [chemical binding]; other site 226185004723 FAD binding motif [chemical binding]; other site 226185004724 phosphate binding motif [ion binding]; other site 226185004725 beta-alpha-beta structure motif; other site 226185004726 NAD binding pocket [chemical binding]; other site 226185004727 Iron coordination center [ion binding]; other site 226185004728 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 226185004729 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 226185004730 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 226185004731 Carbamoyl-phosphate synthetase large chain, oligomerization domain; Region: CPSase_L_D3; pfam02787 226185004732 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 226185004733 ATP-grasp domain; Region: ATP-grasp_4; cl17255 226185004734 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 226185004735 IMP binding site; other site 226185004736 dimer interface [polypeptide binding]; other site 226185004737 interdomain contacts; other site 226185004738 partial ornithine binding site; other site 226185004739 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 226185004740 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 226185004741 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 226185004742 catalytic site [active] 226185004743 subunit interface [polypeptide binding]; other site 226185004744 dihydroorotase; Validated; Region: pyrC; PRK09357 226185004745 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 226185004746 active site 226185004747 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 226185004748 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 226185004749 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 226185004750 Sulfate transporter family; Region: Sulfate_transp; cl19250 226185004751 uracil-xanthine permease; Region: ncs2; TIGR00801 226185004752 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 226185004753 active site 226185004754 lipoprotein signal peptidase; Provisional; Region: PRK14797 226185004755 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 226185004756 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 226185004757 Potassium binding sites [ion binding]; other site 226185004758 Cesium cation binding sites [ion binding]; other site 226185004759 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 226185004760 DNA-binding site [nucleotide binding]; DNA binding site 226185004761 RNA-binding motif; other site 226185004762 RNAse HI family that includes archaeal, some bacterial as well as plant RNase HI; Region: RNase_HI_like; cd09279 226185004763 RNA/DNA hybrid binding site [nucleotide binding]; other site 226185004764 active site 226185004765 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 226185004766 putative deacylase active site [active] 226185004767 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 226185004768 active site 226185004769 catalytic residue [active] 226185004770 dimer interface [polypeptide binding]; other site 226185004771 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 226185004772 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 226185004773 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 226185004774 Walker A/P-loop; other site 226185004775 ATP binding site [chemical binding]; other site 226185004776 Q-loop/lid; other site 226185004777 ABC transporter signature motif; other site 226185004778 Walker B; other site 226185004779 D-loop; other site 226185004780 H-loop/switch region; other site 226185004781 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 226185004782 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 226185004783 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226185004784 Walker A/P-loop; other site 226185004785 ATP binding site [chemical binding]; other site 226185004786 Q-loop/lid; other site 226185004787 ABC transporter signature motif; other site 226185004788 Walker B; other site 226185004789 D-loop; other site 226185004790 H-loop/switch region; other site 226185004791 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 226185004792 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 226185004793 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 226185004794 AP (apurinic/apyrimidinic) site pocket; other site 226185004795 DNA interaction; other site 226185004796 Metal-binding active site; metal-binding site 226185004797 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 226185004798 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 226185004799 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 226185004800 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 226185004801 active site 226185004802 HIGH motif; other site 226185004803 dimer interface [polypeptide binding]; other site 226185004804 KMSKS motif; other site 226185004805 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 226185004806 RNA binding surface [nucleotide binding]; other site 226185004807 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 226185004808 Transglycosylase; Region: Transgly; pfam00912 226185004809 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 226185004810 catabolite control protein A; Region: ccpA; TIGR01481 226185004811 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 226185004812 DNA binding site [nucleotide binding] 226185004813 domain linker motif; other site 226185004814 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 226185004815 dimerization interface [polypeptide binding]; other site 226185004816 effector binding site; other site 226185004817 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 226185004818 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 226185004819 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 226185004820 active site 226185004821 YtxH-like protein; Region: YtxH; cl02079 226185004822 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 226185004823 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 226185004824 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 226185004825 active site 226185004826 tetramer interface; other site 226185004827 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 226185004828 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 226185004829 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 226185004830 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 226185004831 HPr kinase/phosphorylase; Provisional; Region: PRK05428 226185004832 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 226185004833 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 226185004834 Hpr binding site; other site 226185004835 active site 226185004836 homohexamer subunit interaction site [polypeptide binding]; other site 226185004837 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 226185004838 GIY-YIG motif/motif A; other site 226185004839 active site 226185004840 catalytic site [active] 226185004841 putative DNA binding site [nucleotide binding]; other site 226185004842 metal binding site [ion binding]; metal-binding site 226185004843 UvrB/uvrC motif; Region: UVR; pfam02151 226185004844 Membrane protein of unknown function; Region: DUF360; pfam04020 226185004845 PspC domain; Region: PspC; pfam04024 226185004846 Prefoldin subunit; Region: Prefoldin_2; pfam01920 226185004847 Uncharacterized conserved protein [Function unknown]; Region: COG3595 226185004848 Domain of unknown function (DUF4098); Region: DUF4098; cl19992 226185004849 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 226185004850 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 226185004851 PhoU domain; Region: PhoU; pfam01895 226185004852 PhoU domain; Region: PhoU; pfam01895 226185004853 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14255 226185004854 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 226185004855 Walker A/P-loop; other site 226185004856 ATP binding site [chemical binding]; other site 226185004857 Q-loop/lid; other site 226185004858 ABC transporter signature motif; other site 226185004859 Walker B; other site 226185004860 D-loop; other site 226185004861 H-loop/switch region; other site 226185004862 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 226185004863 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 226185004864 Walker A/P-loop; other site 226185004865 ATP binding site [chemical binding]; other site 226185004866 Q-loop/lid; other site 226185004867 ABC transporter signature motif; other site 226185004868 Walker B; other site 226185004869 D-loop; other site 226185004870 H-loop/switch region; other site 226185004871 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 226185004872 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226185004873 dimer interface [polypeptide binding]; other site 226185004874 conserved gate region; other site 226185004875 putative PBP binding loops; other site 226185004876 ABC-ATPase subunit interface; other site 226185004877 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 226185004878 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226185004879 dimer interface [polypeptide binding]; other site 226185004880 conserved gate region; other site 226185004881 putative PBP binding loops; other site 226185004882 ABC-ATPase subunit interface; other site 226185004883 phosphate binding protein; Region: ptsS_2; TIGR02136 226185004884 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 226185004885 FtsX-like permease family; Region: FtsX; pfam02687 226185004886 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 226185004887 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226185004888 Walker A/P-loop; other site 226185004889 ATP binding site [chemical binding]; other site 226185004890 Q-loop/lid; other site 226185004891 ABC transporter signature motif; other site 226185004892 Walker B; other site 226185004893 D-loop; other site 226185004894 H-loop/switch region; other site 226185004895 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 226185004896 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 226185004897 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 226185004898 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226185004899 nucleotide binding region [chemical binding]; other site 226185004900 ATP-binding site [chemical binding]; other site 226185004901 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 226185004902 SEC-C motif; Region: SEC-C; cl19389 226185004903 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 226185004904 30S subunit binding site; other site 226185004905 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 226185004906 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 226185004907 active site 226185004908 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 226185004909 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226185004910 ATP binding site [chemical binding]; other site 226185004911 putative Mg++ binding site [ion binding]; other site 226185004912 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226185004913 nucleotide binding region [chemical binding]; other site 226185004914 ATP-binding site [chemical binding]; other site 226185004915 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 226185004916 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226185004917 Walker A/P-loop; other site 226185004918 ATP binding site [chemical binding]; other site 226185004919 Q-loop/lid; other site 226185004920 ABC transporter signature motif; other site 226185004921 Walker B; other site 226185004922 D-loop; other site 226185004923 H-loop/switch region; other site 226185004924 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 226185004925 active site 226185004926 P-loop; other site 226185004927 phosphorylation site [posttranslational modification] 226185004928 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 226185004929 Uncharacterized conserved protein [Function unknown]; Region: COG1739 226185004930 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 226185004931 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 226185004932 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 226185004933 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 226185004934 classical (c) SDRs; Region: SDR_c; cd05233 226185004935 NAD(P) binding site [chemical binding]; other site 226185004936 active site 226185004937 QueT transporter; Region: QueT; pfam06177 226185004938 Tim44-like domain; Region: Tim44; cl09208 226185004939 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 226185004940 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 226185004941 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 226185004942 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 226185004943 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 226185004944 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 226185004945 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 226185004946 purine monophosphate binding site [chemical binding]; other site 226185004947 dimer interface [polypeptide binding]; other site 226185004948 putative catalytic residues [active] 226185004949 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 226185004950 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 226185004951 active site 226185004952 substrate binding site [chemical binding]; other site 226185004953 cosubstrate binding site; other site 226185004954 catalytic site [active] 226185004955 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 226185004956 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 226185004957 dimerization interface [polypeptide binding]; other site 226185004958 putative ATP binding site [chemical binding]; other site 226185004959 amidophosphoribosyltransferase; Provisional; Region: PRK07272 226185004960 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 226185004961 active site 226185004962 tetramer interface [polypeptide binding]; other site 226185004963 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 226185004964 active site 226185004965 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 226185004966 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 226185004967 dimerization interface [polypeptide binding]; other site 226185004968 ATP binding site [chemical binding]; other site 226185004969 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 226185004970 dimerization interface [polypeptide binding]; other site 226185004971 ATP binding site [chemical binding]; other site 226185004972 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 226185004973 putative active site [active] 226185004974 catalytic triad [active] 226185004975 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 226185004976 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 226185004977 ATP binding site [chemical binding]; other site 226185004978 active site 226185004979 substrate binding site [chemical binding]; other site 226185004980 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 226185004981 ATP-grasp domain; Region: ATP-grasp; pfam02222 226185004982 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 226185004983 Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like_u2; cd03402 226185004984 prohibitin homologues; Region: PHB; smart00244 226185004985 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 226185004986 putative substrate binding site [chemical binding]; other site 226185004987 putative ATP binding site [chemical binding]; other site 226185004988 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 226185004989 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 226185004990 peptide binding site [polypeptide binding]; other site 226185004991 Cupin domain; Region: Cupin_2; pfam07883 226185004992 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 226185004993 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 226185004994 homodimer interface [polypeptide binding]; other site 226185004995 substrate-cofactor binding pocket; other site 226185004996 catalytic residue [active] 226185004997 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 226185004998 Protein of unknown function (DUF998); Region: DUF998; pfam06197 226185004999 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 226185005000 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 226185005001 Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905 226185005002 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 226185005003 active pocket/dimerization site; other site 226185005004 active site 226185005005 phosphorylation site [posttranslational modification] 226185005006 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 226185005007 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 226185005008 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 226185005009 active site 226185005010 phosphorylation site [posttranslational modification] 226185005011 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 226185005012 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 226185005013 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 226185005014 putative substrate binding site [chemical binding]; other site 226185005015 putative ATP binding site [chemical binding]; other site 226185005016 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 226185005017 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 226185005018 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 226185005019 dimer interface [polypeptide binding]; other site 226185005020 active site 226185005021 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 226185005022 putative active site [active] 226185005023 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 226185005024 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226185005025 DNA-binding site [nucleotide binding]; DNA binding site 226185005026 UTRA domain; Region: UTRA; pfam07702 226185005027 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 226185005028 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 226185005029 Ligand binding site; other site 226185005030 metal-binding site 226185005031 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 226185005032 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 226185005033 Ligand binding site; other site 226185005034 metal-binding site 226185005035 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 226185005036 Sulfatase; Region: Sulfatase; pfam00884 226185005037 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226185005038 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226185005039 putative substrate translocation pore; other site 226185005040 Transcriptional regulator [Transcription]; Region: LysR; COG0583 226185005041 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 226185005042 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 226185005043 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 226185005044 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 226185005045 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 226185005046 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 226185005047 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 226185005048 active site 226185005049 Zn binding site [ion binding]; other site 226185005050 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 226185005051 Accessory gene regulator B; Region: AgrB; smart00793 226185005052 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 226185005053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226185005054 active site 226185005055 phosphorylation site [posttranslational modification] 226185005056 intermolecular recognition site; other site 226185005057 dimerization interface [polypeptide binding]; other site 226185005058 LytTr DNA-binding domain; Region: LytTR; pfam04397 226185005059 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 226185005060 NlpC/P60 family; Region: NLPC_P60; cl17555 226185005061 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 226185005062 CHAP domain; Region: CHAP; pfam05257 226185005063 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 226185005064 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 226185005065 CPE1046 is an uncharacterized Clostridium perfringens protein with a glycosyl hydrolase family 31 (GH31) domain. The domain architecture of CPE1046 and its orthologs includes a C-terminal fibronectin type 3 (FN3) domain and a coagulation factor 5/8 type...; Region: GH31_CPE1046; cd06596 226185005066 putative active site [active] 226185005067 putative catalytic site [active] 226185005068 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 226185005069 Interdomain contacts; other site 226185005070 Cytokine receptor motif; other site 226185005071 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 226185005072 Cohesin domain, interaction partner of dockerin; Region: Type_III_cohesin_like; cd08759 226185005073 dockerin binding interface [polypeptide binding]; other site 226185005074 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 226185005075 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cd00176 226185005076 linker region; other site 226185005077 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 226185005078 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 226185005079 NAD binding site [chemical binding]; other site 226185005080 substrate binding site [chemical binding]; other site 226185005081 catalytic Zn binding site [ion binding]; other site 226185005082 tetramer interface [polypeptide binding]; other site 226185005083 structural Zn binding site [ion binding]; other site 226185005084 Protein of unknown function DUF111; Region: DUF111; pfam01969 226185005085 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 226185005086 amphipathic channel; other site 226185005087 Asn-Pro-Ala signature motifs; other site 226185005088 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 226185005089 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 226185005090 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 226185005091 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 226185005092 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 226185005093 active site 226185005094 phosphorylation site [posttranslational modification] 226185005095 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 226185005096 active site 226185005097 P-loop; other site 226185005098 phosphorylation site [posttranslational modification] 226185005099 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 226185005100 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 226185005101 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 226185005102 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 226185005103 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 226185005104 Zn2+ binding site [ion binding]; other site 226185005105 Mg2+ binding site [ion binding]; other site 226185005106 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 226185005107 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 226185005108 NodB motif; other site 226185005109 active site 226185005110 catalytic site [active] 226185005111 Zn binding site [ion binding]; other site 226185005112 AP2-like DNA-binding integrase domain; Region: Integrase_AP2; pfam14657 226185005113 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 226185005114 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 226185005115 active site 226185005116 DNA binding site [nucleotide binding] 226185005117 Int/Topo IB signature motif; other site 226185005118 Helix-turn-helix domain; Region: HTH_17; pfam12728 226185005119 Helix-turn-helix domain; Region: HTH_16; pfam12645 226185005120 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 226185005121 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 226185005122 DNA binding residues [nucleotide binding] 226185005123 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 226185005124 Transposase, Mutator family; Region: Transposase_mut; cl19537 226185005125 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 226185005126 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 226185005127 tetramerization interface [polypeptide binding]; other site 226185005128 active site 226185005129 Pantoate-beta-alanine ligase; Region: PanC; cd00560 226185005130 active site 226185005131 ATP-binding site [chemical binding]; other site 226185005132 pantoate-binding site; other site 226185005133 HXXH motif; other site 226185005134 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 226185005135 active site 226185005136 oligomerization interface [polypeptide binding]; other site 226185005137 metal binding site [ion binding]; metal-binding site 226185005138 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 226185005139 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 226185005140 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226185005141 HAMP domain; Region: HAMP; pfam00672 226185005142 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226185005143 dimer interface [polypeptide binding]; other site 226185005144 phosphorylation site [posttranslational modification] 226185005145 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226185005146 ATP binding site [chemical binding]; other site 226185005147 Mg2+ binding site [ion binding]; other site 226185005148 G-X-G motif; other site 226185005149 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226185005150 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226185005151 active site 226185005152 phosphorylation site [posttranslational modification] 226185005153 intermolecular recognition site; other site 226185005154 dimerization interface [polypeptide binding]; other site 226185005155 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226185005156 DNA binding site [nucleotide binding] 226185005157 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 226185005158 FtsX-like permease family; Region: FtsX; pfam02687 226185005159 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 226185005160 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 226185005161 Walker A/P-loop; other site 226185005162 ATP binding site [chemical binding]; other site 226185005163 Q-loop/lid; other site 226185005164 ABC transporter signature motif; other site 226185005165 Walker B; other site 226185005166 D-loop; other site 226185005167 H-loop/switch region; other site 226185005168 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 226185005169 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 226185005170 FtsX-like permease family; Region: FtsX; pfam02687 226185005171 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 226185005172 catalytic residues [active] 226185005173 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 226185005174 Transposase, Mutator family; Region: Transposase_mut; cl19537 226185005175 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 226185005176 Lysozyme-like; Region: Lysozyme_like; pfam13702 226185005177 catalytic residue [active] 226185005178 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 226185005179 NlpC/P60 family; Region: NLPC_P60; pfam00877 226185005180 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 226185005181 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 226185005182 AAA-like domain; Region: AAA_10; pfam12846 226185005183 TcpE family; Region: TcpE; pfam12648 226185005184 Abortive infection C-terminus; Region: Abi_C; pfam14355 226185005185 Antirestriction protein (ArdA); Region: ArdA; pfam07275 226185005186 Transposase; Region: DEDD_Tnp_IS110; pfam01548 226185005187 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 226185005188 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 226185005189 Protein of unknown function (DUF3789); Region: DUF3789; pfam12664 226185005190 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226185005191 non-specific DNA binding site [nucleotide binding]; other site 226185005192 salt bridge; other site 226185005193 sequence-specific DNA binding site [nucleotide binding]; other site 226185005194 Replication initiation factor; Region: Rep_trans; pfam02486 226185005195 Zeta toxin; Region: Zeta_toxin; pfam06414 226185005196 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 226185005197 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 226185005198 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 226185005199 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 226185005200 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 226185005201 Cna protein B-type domain; Region: Cna_B; pfam05738 226185005202 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 226185005203 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 226185005204 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 226185005205 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 226185005206 RimM N-terminal domain; Region: RimM; pfam01782 226185005207 PRC-barrel domain; Region: PRC; pfam05239 226185005208 manganese transport protein MntH; Reviewed; Region: PRK00701 226185005209 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 226185005210 Mitomycin C resistance protein (MRD); Region: MRD; cd07235 226185005211 dimer interface [polypeptide binding]; other site 226185005212 ligand binding site [chemical binding]; other site 226185005213 Uncharacterized conserved protein [Function unknown]; Region: COG0398 226185005214 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 226185005215 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 226185005216 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 226185005217 putative active site [active] 226185005218 catalytic site [active] 226185005219 putative metal binding site [ion binding]; other site 226185005220 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 226185005221 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 226185005222 active site 2 [active] 226185005223 active site 1 [active] 226185005224 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 226185005225 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 226185005226 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 226185005227 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 226185005228 Predicted membrane protein [Function unknown]; Region: COG4129 226185005229 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 226185005230 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 226185005231 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 226185005232 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 226185005233 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 226185005234 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 226185005235 nucleotide binding site [chemical binding]; other site 226185005236 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 226185005237 Haemolytic domain; Region: Haemolytic; pfam01809 226185005238 Predicted GTPase [General function prediction only]; Region: COG0218 226185005239 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 226185005240 G1 box; other site 226185005241 GTP/Mg2+ binding site [chemical binding]; other site 226185005242 Switch I region; other site 226185005243 G2 box; other site 226185005244 G3 box; other site 226185005245 Switch II region; other site 226185005246 G4 box; other site 226185005247 G5 box; other site 226185005248 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 226185005249 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 226185005250 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226185005251 Walker A motif; other site 226185005252 ATP binding site [chemical binding]; other site 226185005253 Walker B motif; other site 226185005254 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 226185005255 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 226185005256 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226185005257 Coenzyme A binding pocket [chemical binding]; other site 226185005258 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; cl17322 226185005259 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069 226185005260 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 226185005261 active site 226185005262 tetramer interface [polypeptide binding]; other site 226185005263 Transcriptional regulators [Transcription]; Region: PurR; COG1609 226185005264 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 226185005265 DNA binding site [nucleotide binding] 226185005266 Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability; Region: PBP1_FucR_like; cd06276 226185005267 putative dimerization interface [polypeptide binding]; other site 226185005268 putative ligand binding site [chemical binding]; other site 226185005269 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 226185005270 substrate binding site [chemical binding]; other site 226185005271 dimer interface [polypeptide binding]; other site 226185005272 ATP binding site [chemical binding]; other site 226185005273 Mga helix-turn-helix domain; Region: Mga; pfam05043 226185005274 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 226185005275 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 226185005276 amphipathic channel; other site 226185005277 Asn-Pro-Ala signature motifs; other site 226185005278 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 226185005279 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 226185005280 glycerol kinase; Provisional; Region: glpK; PRK00047 226185005281 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 226185005282 N- and C-terminal domain interface [polypeptide binding]; other site 226185005283 active site 226185005284 MgATP binding site [chemical binding]; other site 226185005285 catalytic site [active] 226185005286 metal binding site [ion binding]; metal-binding site 226185005287 glycerol binding site [chemical binding]; other site 226185005288 homotetramer interface [polypeptide binding]; other site 226185005289 homodimer interface [polypeptide binding]; other site 226185005290 FBP binding site [chemical binding]; other site 226185005291 protein IIAGlc interface [polypeptide binding]; other site 226185005292 Mga helix-turn-helix domain; Region: Mga; pfam05043 226185005293 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 226185005294 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 226185005295 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 226185005296 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 226185005297 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 226185005298 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 226185005299 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 226185005300 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 226185005301 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 226185005302 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226185005303 motif II; other site 226185005304 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 226185005305 Predicted membrane protein [Function unknown]; Region: COG2364 226185005306 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 226185005307 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 226185005308 ligand binding site [chemical binding]; other site 226185005309 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 226185005310 putative switch regulator; other site 226185005311 non-specific DNA interactions [nucleotide binding]; other site 226185005312 DNA binding site [nucleotide binding] 226185005313 sequence specific DNA binding site [nucleotide binding]; other site 226185005314 putative cAMP binding site [chemical binding]; other site 226185005315 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 226185005316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226185005317 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 226185005318 putative substrate translocation pore; other site 226185005319 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 226185005320 Sulfatase; Region: Sulfatase; pfam00884 226185005321 Domain of unknown function (DU1801); Region: DUF1801; cl17490 226185005322 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 226185005323 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 226185005324 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 226185005325 putative active site [active] 226185005326 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 226185005327 Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains [Cell envelope biogenesis, outer membrane]; Region: GlmS; COG0449 226185005328 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 226185005329 dimer interface [polypeptide binding]; other site 226185005330 active site 226185005331 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 226185005332 dimer interface [polypeptide binding]; other site 226185005333 active site 226185005334 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 226185005335 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 226185005336 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 226185005337 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226185005338 Walker A motif; other site 226185005339 ATP binding site [chemical binding]; other site 226185005340 Walker B motif; other site 226185005341 arginine finger; other site 226185005342 Transcriptional antiterminator [Transcription]; Region: COG3933 226185005343 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 226185005344 active pocket/dimerization site; other site 226185005345 active site 226185005346 phosphorylation site [posttranslational modification] 226185005347 PRD domain; Region: PRD; pfam00874 226185005348 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 226185005349 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 226185005350 Zn2+ binding site [ion binding]; other site 226185005351 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cl07889 226185005352 peptidase domain interface [polypeptide binding]; other site 226185005353 Mg2+ binding site [ion binding]; other site 226185005354 TIR domain; Region: TIR_2; pfam13676 226185005355 enolase; Provisional; Region: eno; PRK00077 226185005356 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 226185005357 dimer interface [polypeptide binding]; other site 226185005358 metal binding site [ion binding]; metal-binding site 226185005359 substrate binding pocket [chemical binding]; other site 226185005360 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 226185005361 substrate binding site [chemical binding]; other site 226185005362 dimer interface [polypeptide binding]; other site 226185005363 catalytic triad [active] 226185005364 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 226185005365 substrate binding site [chemical binding]; other site 226185005366 hinge regions; other site 226185005367 ADP binding site [chemical binding]; other site 226185005368 catalytic site [active] 226185005369 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 226185005370 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 226185005371 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 226185005372 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 226185005373 Predicted transcriptional regulator [Transcription]; Region: COG3388 226185005374 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 226185005375 Uncharacterized conserved protein [Function unknown]; Region: COG1284 226185005376 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 226185005377 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 226185005378 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 226185005379 Protein of unknown function (DUF436); Region: DUF436; pfam04260 226185005380 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 226185005381 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 226185005382 dimer interface [polypeptide binding]; other site 226185005383 substrate binding site [chemical binding]; other site 226185005384 ATP binding site [chemical binding]; other site 226185005385 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 226185005386 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 226185005387 dimer interface [polypeptide binding]; other site 226185005388 anticodon binding site; other site 226185005389 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 226185005390 homodimer interface [polypeptide binding]; other site 226185005391 motif 1; other site 226185005392 active site 226185005393 motif 2; other site 226185005394 GAD domain; Region: GAD; pfam02938 226185005395 motif 3; other site 226185005396 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 226185005397 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 226185005398 dimer interface [polypeptide binding]; other site 226185005399 motif 1; other site 226185005400 active site 226185005401 motif 2; other site 226185005402 motif 3; other site 226185005403 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 226185005404 anticodon binding site; other site 226185005405 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 226185005406 putative active site [active] 226185005407 dimerization interface [polypeptide binding]; other site 226185005408 putative tRNAtyr binding site [nucleotide binding]; other site 226185005409 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 226185005410 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 226185005411 Zn2+ binding site [ion binding]; other site 226185005412 Mg2+ binding site [ion binding]; other site 226185005413 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 226185005414 synthetase active site [active] 226185005415 NTP binding site [chemical binding]; other site 226185005416 metal binding site [ion binding]; metal-binding site 226185005417 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 226185005418 DNA polymerase III polC-type N-terminus II; Region: DNA_pol3_a_NII; pfam11490 226185005419 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 226185005420 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 226185005421 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 226185005422 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226185005423 S-adenosylmethionine binding site [chemical binding]; other site 226185005424 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 226185005425 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 226185005426 active site 226185005427 DNA binding site [nucleotide binding] 226185005428 recombination factor protein RarA; Reviewed; Region: PRK13342 226185005429 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226185005430 Walker A motif; other site 226185005431 ATP binding site [chemical binding]; other site 226185005432 Walker B motif; other site 226185005433 arginine finger; other site 226185005434 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 226185005435 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 226185005436 Ligand Binding Site [chemical binding]; other site 226185005437 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 226185005438 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 226185005439 nucleotide binding site [chemical binding]; other site 226185005440 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 226185005441 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 226185005442 PHAGE04, prophage. 226185005443 Ferrochelatase; Region: Ferrochelatase; pfam00762 226185005444 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 226185005445 C-terminal domain interface [polypeptide binding]; other site 226185005446 active site 226185005447 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 226185005448 active site 226185005449 N-terminal domain interface [polypeptide binding]; other site 226185005450 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 226185005451 DNA-binding site [nucleotide binding]; DNA binding site 226185005452 RNA-binding motif; other site 226185005453 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 226185005454 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 226185005455 active site 226185005456 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 226185005457 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 226185005458 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 226185005459 Bacteriophage holin; Region: Phage_holin_1; pfam04531 226185005460 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 226185005461 Prophage endopeptidase tail; Region: Prophage_tail; cl19379 226185005462 Phage tail protein; Region: Sipho_tail; cl17486 226185005463 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 226185005464 tape measure domain; Region: tape_meas_nterm; TIGR02675 226185005465 Phage-related protein [Function unknown]; Region: COG5412 226185005466 Protein of unknown function (DUF499); Region: DUF499; cl19819 226185005467 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 226185005468 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 226185005469 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 226185005470 Bacteriophage HK97-gp10, putative tail-component; Region: HK97-gp10_like; pfam04883 226185005471 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 226185005472 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 226185005473 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; cl19531 226185005474 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 226185005475 Terminase-like family; Region: Terminase_6; pfam03237 226185005476 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 226185005477 Homeodomain-like domain; Region: HTH_23; pfam13384 226185005478 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 226185005479 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 226185005480 Helix-turn-helix domain; Region: HTH_36; pfam13730 226185005481 ERF superfamily; Region: ERF; pfam04404 226185005482 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 226185005483 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 226185005484 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 226185005485 ORF6C domain; Region: ORF6C; pfam10552 226185005486 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226185005487 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226185005488 non-specific DNA binding site [nucleotide binding]; other site 226185005489 salt bridge; other site 226185005490 sequence-specific DNA binding site [nucleotide binding]; other site 226185005491 Domain of unknown function (DUF955); Region: DUF955; cl01076 226185005492 Short C-terminal domain; Region: SHOCT; pfam09851 226185005493 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 226185005494 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 226185005495 Int/Topo IB signature motif; other site 226185005496 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 226185005497 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 226185005498 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 226185005499 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 226185005500 Walker A motif; other site 226185005501 ATP binding site [chemical binding]; other site 226185005502 Walker B motif; other site 226185005503 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 226185005504 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 226185005505 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 226185005506 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226185005507 FeS/SAM binding site; other site 226185005508 FtsX-like permease family; Region: FtsX; pfam02687 226185005509 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 226185005510 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 226185005511 Walker A/P-loop; other site 226185005512 ATP binding site [chemical binding]; other site 226185005513 Q-loop/lid; other site 226185005514 ABC transporter signature motif; other site 226185005515 Walker B; other site 226185005516 D-loop; other site 226185005517 H-loop/switch region; other site 226185005518 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 226185005519 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226185005520 DNA-binding site [nucleotide binding]; DNA binding site 226185005521 UTRA domain; Region: UTRA; pfam07702 226185005522 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 226185005523 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 226185005524 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 226185005525 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 226185005526 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 226185005527 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 226185005528 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 226185005529 putative active site [active] 226185005530 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 226185005531 substrate binding pocket [chemical binding]; other site 226185005532 chain length determination region; other site 226185005533 substrate-Mg2+ binding site; other site 226185005534 catalytic residues [active] 226185005535 aspartate-rich region 1; other site 226185005536 active site lid residues [active] 226185005537 aspartate-rich region 2; other site 226185005538 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 226185005539 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 226185005540 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 226185005541 Walker A/P-loop; other site 226185005542 ATP binding site [chemical binding]; other site 226185005543 Q-loop/lid; other site 226185005544 ABC transporter signature motif; other site 226185005545 Walker B; other site 226185005546 D-loop; other site 226185005547 H-loop/switch region; other site 226185005548 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 226185005549 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 226185005550 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226185005551 Walker A/P-loop; other site 226185005552 ATP binding site [chemical binding]; other site 226185005553 Q-loop/lid; other site 226185005554 ABC transporter signature motif; other site 226185005555 Walker B; other site 226185005556 D-loop; other site 226185005557 H-loop/switch region; other site 226185005558 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 226185005559 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 226185005560 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 226185005561 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226185005562 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226185005563 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 226185005564 DNA topoisomerase III; Provisional; Region: PRK07726 226185005565 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 226185005566 active site 226185005567 putative interdomain interaction site [polypeptide binding]; other site 226185005568 putative metal-binding site [ion binding]; other site 226185005569 putative nucleotide binding site [chemical binding]; other site 226185005570 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 226185005571 domain I; other site 226185005572 DNA binding groove [nucleotide binding] 226185005573 phosphate binding site [ion binding]; other site 226185005574 domain II; other site 226185005575 domain III; other site 226185005576 nucleotide binding site [chemical binding]; other site 226185005577 catalytic site [active] 226185005578 domain IV; other site 226185005579 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 226185005580 Protein of unknown function (DUF1033); Region: DUF1033; pfam06279 226185005581 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226185005582 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 226185005583 WHG domain; Region: WHG; pfam13305 226185005584 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 226185005585 substrate binding site [chemical binding]; other site 226185005586 drug efflux system protein MdtG; Provisional; Region: PRK09874 226185005587 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226185005588 putative substrate translocation pore; other site 226185005589 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 226185005590 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 226185005591 Ligand Binding Site [chemical binding]; other site 226185005592 Putative amino acid metabolizm; Region: DUF1831; pfam08866 226185005593 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 226185005594 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 226185005595 catalytic residue [active] 226185005596 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458 226185005597 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 226185005598 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 226185005599 active site 226185005600 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 226185005601 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 226185005602 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 226185005603 ABC-ATPase subunit interface; other site 226185005604 dimer interface [polypeptide binding]; other site 226185005605 putative PBP binding regions; other site 226185005606 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 226185005607 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 226185005608 metal binding site [ion binding]; metal-binding site 226185005609 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 226185005610 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 226185005611 ABC transporter; Region: ABC_tran_2; pfam12848 226185005612 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 226185005613 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 226185005614 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 226185005615 metal binding site [ion binding]; metal-binding site 226185005616 putative dimer interface [polypeptide binding]; other site 226185005617 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 226185005618 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226185005619 dimer interface [polypeptide binding]; other site 226185005620 conserved gate region; other site 226185005621 putative PBP binding loops; other site 226185005622 ABC-ATPase subunit interface; other site 226185005623 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 226185005624 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 226185005625 Walker A/P-loop; other site 226185005626 ATP binding site [chemical binding]; other site 226185005627 Q-loop/lid; other site 226185005628 ABC transporter signature motif; other site 226185005629 Walker B; other site 226185005630 D-loop; other site 226185005631 H-loop/switch region; other site 226185005632 NIL domain; Region: NIL; pfam09383 226185005633 PHAGE05, prophage. 226185005634 Abi-like protein; Region: Abi_2; cl01988 226185005635 LysA is a cell wall endolysin produced by Lactobacillus fermentum, which degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. The N-terminal glycosyl hydrolase...; Region: GH25_LysA-like; cd06417 226185005636 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 226185005637 active site 226185005638 phosphodiesterase; Provisional; Region: PRK12704 226185005639 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 226185005640 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 226185005641 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 226185005642 Bacteriophage peptidoglycan hydrolase; Region: Amidase_5; pfam05382 226185005643 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 226185005644 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 226185005645 TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926 226185005646 tape measure domain; Region: tape_meas_nterm; TIGR02675 226185005647 Bacteriophage HK97-gp10, putative tail-component; Region: HK97-gp10_like; pfam04883 226185005648 MAEBL; Provisional; Region: PTZ00121 226185005649 Terminase-like family; Region: Terminase_6; pfam03237 226185005650 Stress-induced bacterial acidophilic repeat motif; Region: KGG; pfam10685 226185005651 ParB-like nuclease domain; Region: ParBc; pfam02195 226185005652 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 226185005653 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 226185005654 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 226185005655 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 226185005656 Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961 226185005657 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226185005658 S-adenosylmethionine binding site [chemical binding]; other site 226185005659 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 226185005660 Nudix N-terminal; Region: Nudix_N_2; pfam14803 226185005661 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226185005662 Walker A motif; other site 226185005663 ATP binding site [chemical binding]; other site 226185005664 Walker B motif; other site 226185005665 Domain of unknown function (DUF4373); Region: DUF4373; pfam14297 226185005666 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 226185005667 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 226185005668 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 226185005669 RecT family; Region: RecT; pfam03837 226185005670 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226185005671 sequence-specific DNA binding site [nucleotide binding]; other site 226185005672 salt bridge; other site 226185005673 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226185005674 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226185005675 non-specific DNA binding site [nucleotide binding]; other site 226185005676 salt bridge; other site 226185005677 sequence-specific DNA binding site [nucleotide binding]; other site 226185005678 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226185005679 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226185005680 non-specific DNA binding site [nucleotide binding]; other site 226185005681 salt bridge; other site 226185005682 sequence-specific DNA binding site [nucleotide binding]; other site 226185005683 Domain of unknown function (DUF955); Region: DUF955; pfam06114 226185005684 Rhoptry-associated protein 1 (RAP-1); Region: RAP1; pfam07218 226185005685 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 226185005686 Int/Topo IB signature motif; other site 226185005687 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 226185005688 FemAB family; Region: FemAB; pfam02388 226185005689 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 226185005690 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 226185005691 glutaminase active site [active] 226185005692 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 226185005693 dimer interface [polypeptide binding]; other site 226185005694 active site 226185005695 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 226185005696 dimer interface [polypeptide binding]; other site 226185005697 active site 226185005698 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 226185005699 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 226185005700 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 226185005701 Walker A/P-loop; other site 226185005702 ATP binding site [chemical binding]; other site 226185005703 Q-loop/lid; other site 226185005704 ABC transporter signature motif; other site 226185005705 Walker B; other site 226185005706 D-loop; other site 226185005707 H-loop/switch region; other site 226185005708 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 226185005709 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 226185005710 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 226185005711 Walker A/P-loop; other site 226185005712 ATP binding site [chemical binding]; other site 226185005713 Q-loop/lid; other site 226185005714 ABC transporter signature motif; other site 226185005715 Walker B; other site 226185005716 D-loop; other site 226185005717 H-loop/switch region; other site 226185005718 hypothetical protein; Provisional; Region: PRK13661 226185005719 YbbR-like protein; Region: YbbR; pfam07949 226185005720 YbbR-like protein; Region: YbbR; pfam07949 226185005721 Uncharacterized conserved protein [Function unknown]; Region: COG1624 226185005722 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 226185005723 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 226185005724 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 226185005725 dimer interface [polypeptide binding]; other site 226185005726 PYR/PP interface [polypeptide binding]; other site 226185005727 TPP binding site [chemical binding]; other site 226185005728 substrate binding site [chemical binding]; other site 226185005729 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 226185005730 Domain of unknown function; Region: EKR; pfam10371 226185005731 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 226185005732 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 226185005733 TPP-binding site [chemical binding]; other site 226185005734 dimer interface [polypeptide binding]; other site 226185005735 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 226185005736 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 226185005737 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 226185005738 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 226185005739 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 226185005740 DNA binding residues [nucleotide binding] 226185005741 putative dimer interface [polypeptide binding]; other site 226185005742 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 226185005743 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 226185005744 HflX GTPase family; Region: HflX; cd01878 226185005745 G1 box; other site 226185005746 GTP/Mg2+ binding site [chemical binding]; other site 226185005747 Switch I region; other site 226185005748 G2 box; other site 226185005749 G3 box; other site 226185005750 Switch II region; other site 226185005751 G4 box; other site 226185005752 G5 box; other site 226185005753 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 226185005754 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 226185005755 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 226185005756 active site 226185005757 catalytic site [active] 226185005758 metal binding site [ion binding]; metal-binding site 226185005759 dimer interface [polypeptide binding]; other site 226185005760 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 226185005761 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226185005762 NAD(P) binding site [chemical binding]; other site 226185005763 active site 226185005764 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 226185005765 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 226185005766 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 226185005767 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 226185005768 Probable Catalytic site; other site 226185005769 LicD family; Region: LicD; cl01378 226185005770 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 226185005771 O-Antigen ligase; Region: Wzy_C; pfam04932 226185005772 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 226185005773 active site 226185005774 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226185005775 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 226185005776 NAD(P) binding site [chemical binding]; other site 226185005777 active site 226185005778 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 226185005779 substrate binding site; other site 226185005780 dimer interface; other site 226185005781 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 226185005782 Transposase, Mutator family; Region: Transposase_mut; cl19537 226185005783 AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and Aml...; Region: GH25_AtlA-like; cd06522 226185005784 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 226185005785 active site 226185005786 LicD family; Region: LicD; cl01378 226185005787 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 226185005788 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 226185005789 active site 226185005790 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 226185005791 Bacterial sugar transferase; Region: Bac_transf; pfam02397 226185005792 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 226185005793 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 226185005794 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 226185005795 Probable Catalytic site; other site 226185005796 metal-binding site 226185005797 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 226185005798 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 226185005799 Probable Catalytic site; other site 226185005800 metal-binding site 226185005801 Methyltransferase domain; Region: Methyltransf_31; pfam13847 226185005802 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226185005803 S-adenosylmethionine binding site [chemical binding]; other site 226185005804 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 226185005805 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 226185005806 Probable Catalytic site; other site 226185005807 metal-binding site 226185005808 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226185005809 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226185005810 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 226185005811 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 226185005812 Walker A/P-loop; other site 226185005813 ATP binding site [chemical binding]; other site 226185005814 Q-loop/lid; other site 226185005815 ABC transporter signature motif; other site 226185005816 Walker B; other site 226185005817 D-loop; other site 226185005818 H-loop/switch region; other site 226185005819 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 226185005820 putative carbohydrate binding site [chemical binding]; other site 226185005821 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 226185005822 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 226185005823 Transposase, Mutator family; Region: Transposase_mut; cl19537 226185005824 Transposase, Mutator family; Region: Transposase_mut; pfam00872 226185005825 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 226185005826 Acyltransferase family; Region: Acyl_transf_3; cl19154 226185005827 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 226185005828 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 226185005829 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 226185005830 Ligand binding site; other site 226185005831 Putative Catalytic site; other site 226185005832 DXD motif; other site 226185005833 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 226185005834 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 226185005835 NADP binding site [chemical binding]; other site 226185005836 active site 226185005837 putative substrate binding site [chemical binding]; other site 226185005838 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 226185005839 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 226185005840 NAD binding site [chemical binding]; other site 226185005841 substrate binding site [chemical binding]; other site 226185005842 homodimer interface [polypeptide binding]; other site 226185005843 active site 226185005844 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 226185005845 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 226185005846 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 226185005847 substrate binding site; other site 226185005848 tetramer interface; other site 226185005849 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 226185005850 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 226185005851 Probable Catalytic site; other site 226185005852 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 226185005853 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226185005854 active site 226185005855 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 226185005856 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 226185005857 Probable Catalytic site; other site 226185005858 metal-binding site 226185005859 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 226185005860 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 226185005861 Mg++ binding site [ion binding]; other site 226185005862 putative catalytic motif [active] 226185005863 substrate binding site [chemical binding]; other site 226185005864 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 226185005865 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 226185005866 active site 226185005867 flavodoxin; Validated; Region: PRK07308 226185005868 TspO/MBR family; Region: TspO_MBR; pfam03073 226185005869 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226185005870 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 226185005871 WHG domain; Region: WHG; pfam13305 226185005872 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 226185005873 pentamer interface [polypeptide binding]; other site 226185005874 dodecaamer interface [polypeptide binding]; other site 226185005875 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 226185005876 nucleoside/Zn binding site; other site 226185005877 dimer interface [polypeptide binding]; other site 226185005878 catalytic motif [active] 226185005879 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 226185005880 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 226185005881 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 226185005882 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 226185005883 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 226185005884 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 226185005885 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 226185005886 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 226185005887 active site turn [active] 226185005888 phosphorylation site [posttranslational modification] 226185005889 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 226185005890 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 226185005891 putative metal binding site [ion binding]; other site 226185005892 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 226185005893 putative hydrophobic ligand binding site [chemical binding]; other site 226185005894 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 226185005895 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 226185005896 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 226185005897 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 226185005898 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226185005899 active site 226185005900 phosphorylation site [posttranslational modification] 226185005901 intermolecular recognition site; other site 226185005902 dimerization interface [polypeptide binding]; other site 226185005903 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226185005904 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226185005905 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 226185005906 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226185005907 dimerization interface [polypeptide binding]; other site 226185005908 Histidine kinase; Region: His_kinase; pfam06580 226185005909 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226185005910 ATP binding site [chemical binding]; other site 226185005911 Mg2+ binding site [ion binding]; other site 226185005912 G-X-G motif; other site 226185005913 Protein of unknown function, DUF624; Region: DUF624; cl02369 226185005914 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 226185005915 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 226185005916 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 226185005917 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 226185005918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226185005919 dimer interface [polypeptide binding]; other site 226185005920 ABC-ATPase subunit interface; other site 226185005921 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226185005922 dimer interface [polypeptide binding]; other site 226185005923 conserved gate region; other site 226185005924 putative PBP binding loops; other site 226185005925 ABC-ATPase subunit interface; other site 226185005926 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 226185005927 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 226185005928 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226185005929 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226185005930 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 226185005931 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226185005932 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 226185005933 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226185005934 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226185005935 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 226185005936 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 226185005937 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 226185005938 DNA binding residues [nucleotide binding] 226185005939 dimer interface [polypeptide binding]; other site 226185005940 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 226185005941 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 226185005942 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 226185005943 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226185005944 Walker A/P-loop; other site 226185005945 ATP binding site [chemical binding]; other site 226185005946 Q-loop/lid; other site 226185005947 ABC transporter signature motif; other site 226185005948 Walker B; other site 226185005949 D-loop; other site 226185005950 H-loop/switch region; other site 226185005951 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 226185005952 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 226185005953 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 226185005954 Walker A/P-loop; other site 226185005955 ATP binding site [chemical binding]; other site 226185005956 Q-loop/lid; other site 226185005957 ABC transporter signature motif; other site 226185005958 Walker B; other site 226185005959 D-loop; other site 226185005960 H-loop/switch region; other site 226185005961 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 226185005962 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 226185005963 active site 226185005964 HIGH motif; other site 226185005965 dimer interface [polypeptide binding]; other site 226185005966 KMSKS motif; other site 226185005967 Right handed beta helix region; Region: Beta_helix; pfam13229 226185005968 Right handed beta helix region; Region: Beta_helix; pfam13229 226185005969 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 226185005970 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 226185005971 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 226185005972 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 226185005973 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226185005974 dimer interface [polypeptide binding]; other site 226185005975 conserved gate region; other site 226185005976 putative PBP binding loops; other site 226185005977 ABC-ATPase subunit interface; other site 226185005978 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 226185005979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226185005980 dimer interface [polypeptide binding]; other site 226185005981 conserved gate region; other site 226185005982 putative PBP binding loops; other site 226185005983 ABC-ATPase subunit interface; other site 226185005984 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 226185005985 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 226185005986 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 226185005987 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 226185005988 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 226185005989 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 226185005990 generic binding surface I; other site 226185005991 generic binding surface II; other site 226185005992 Transcriptional regulators [Transcription]; Region: PurR; COG1609 226185005993 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 226185005994 DNA binding site [nucleotide binding] 226185005995 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 226185005996 putative dimerization interface [polypeptide binding]; other site 226185005997 putative ligand binding site [chemical binding]; other site 226185005998 AP2-like DNA-binding integrase domain; Region: Integrase_AP2; pfam14657 226185005999 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 226185006000 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 226185006001 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 226185006002 Int/Topo IB signature motif; other site 226185006003 Domain of unknown function (DUF3173); Region: DUF3173; pfam11372 226185006004 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226185006005 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 226185006006 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226185006007 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 226185006008 DNA binding site [nucleotide binding] 226185006009 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 226185006010 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 226185006011 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 226185006012 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 226185006013 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 226185006014 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 226185006015 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 226185006016 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 226185006017 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 226185006018 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 226185006019 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 226185006020 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 226185006021 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 226185006022 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 226185006023 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 226185006024 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 226185006025 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 226185006026 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 226185006027 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 226185006028 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 226185006029 WxL domain surface cell wall-binding; Region: WxL; pfam13731 226185006030 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 226185006031 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 226185006032 WxL domain surface cell wall-binding; Region: WxL; pfam13731 226185006033 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 226185006034 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 226185006035 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 226185006036 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 226185006037 WxL domain surface cell wall-binding; Region: WxL; pfam13731 226185006038 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 226185006039 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 226185006040 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 226185006041 active site 226185006042 DNA binding site [nucleotide binding] 226185006043 Int/Topo IB signature motif; other site 226185006044 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 226185006045 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 226185006046 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 226185006047 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 226185006048 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 226185006049 putative active site [active] 226185006050 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl19067 226185006051 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 226185006052 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 226185006053 NADP binding site [chemical binding]; other site 226185006054 homodimer interface [polypeptide binding]; other site 226185006055 active site 226185006056 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 226185006057 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 226185006058 substrate binding site [chemical binding]; other site 226185006059 ATP binding site [chemical binding]; other site 226185006060 Entner-Doudoroff aldolase; Region: eda; TIGR01182 226185006061 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 226185006062 active site 226185006063 intersubunit interface [polypeptide binding]; other site 226185006064 catalytic residue [active] 226185006065 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 226185006066 active pocket/dimerization site; other site 226185006067 active site 226185006068 phosphorylation site [posttranslational modification] 226185006069 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 226185006070 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 226185006071 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 226185006072 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 226185006073 active site 226185006074 phosphorylation site [posttranslational modification] 226185006075 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 226185006076 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 226185006077 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226185006078 DNA-binding site [nucleotide binding]; DNA binding site 226185006079 UTRA domain; Region: UTRA; cl17743 226185006080 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 226185006081 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 226185006082 Lysozyme-like; Region: Lysozyme_like; pfam13702 226185006083 catalytic residue [active] 226185006084 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 226185006085 NlpC/P60 family; Region: NLPC_P60; pfam00877 226185006086 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 226185006087 AAA-like domain; Region: AAA_10; pfam12846 226185006088 TcpE family; Region: TcpE; pfam12648 226185006089 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 226185006090 Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770 226185006091 putative catalytic residues [active] 226185006092 catalytic nucleophile [active] 226185006093 Recombinase; Region: Recombinase; pfam07508 226185006094 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 226185006095 Domain of unknown function (DUF4368); Region: DUF4368; pfam14287 226185006096 DNA-sulfur modification-associated; Region: DndB; cl17621 226185006097 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 226185006098 ParB-like nuclease domain; Region: ParB; smart00470 226185006099 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl15270 226185006100 Glucocorticoid receptor; Region: GCR; pfam02155 226185006101 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 226185006102 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226185006103 DNA binding residues [nucleotide binding] 226185006104 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226185006105 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226185006106 non-specific DNA binding site [nucleotide binding]; other site 226185006107 salt bridge; other site 226185006108 sequence-specific DNA binding site [nucleotide binding]; other site 226185006109 D-ala-D-ala dipeptidase; Region: Peptidase_M15; pfam01427 226185006110 D-alanine--D-lactate ligase; Provisional; Region: vanB; PRK14568 226185006111 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 226185006112 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 226185006113 Putative Lactate dehydrogenase and (R)-2-Hydroxyglutarate Dehydrogenase-like proteins, NAD-binding and catalytic domains; Region: HGDH_LDH_like; cd12185 226185006114 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 226185006115 putative ligand binding site [chemical binding]; other site 226185006116 putative NAD binding site [chemical binding]; other site 226185006117 catalytic site [active] 226185006118 VanW like protein; Region: VanW; pfam04294 226185006119 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 226185006120 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226185006121 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226185006122 dimerization interface [polypeptide binding]; other site 226185006123 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226185006124 dimer interface [polypeptide binding]; other site 226185006125 phosphorylation site [posttranslational modification] 226185006126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226185006127 ATP binding site [chemical binding]; other site 226185006128 Mg2+ binding site [ion binding]; other site 226185006129 G-X-G motif; other site 226185006130 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226185006131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226185006132 active site 226185006133 phosphorylation site [posttranslational modification] 226185006134 intermolecular recognition site; other site 226185006135 dimerization interface [polypeptide binding]; other site 226185006136 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226185006137 DNA binding site [nucleotide binding] 226185006138 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 226185006139 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 226185006140 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl19391 226185006141 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226185006142 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226185006143 non-specific DNA binding site [nucleotide binding]; other site 226185006144 salt bridge; other site 226185006145 sequence-specific DNA binding site [nucleotide binding]; other site 226185006146 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 226185006147 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 226185006148 active site 226185006149 metal binding site [ion binding]; metal-binding site 226185006150 interdomain interaction site; other site 226185006151 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 226185006152 MutS domain I; Region: MutS_I; pfam01624 226185006153 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 226185006154 Methyltransferase domain; Region: Methyltransf_26; pfam13659 226185006155 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 226185006156 DEAD-like helicases superfamily; Region: DEXDc; smart00487 226185006157 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 226185006158 helicase superfamily c-terminal domain; Region: HELICc; smart00490 226185006159 Domain of unknown function (DUF4316); Region: DUF4316; pfam14195 226185006160 DNA topoisomerase III; Provisional; Region: PRK07726 226185006161 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 226185006162 active site 226185006163 putative interdomain interaction site [polypeptide binding]; other site 226185006164 putative metal-binding site [ion binding]; other site 226185006165 putative nucleotide binding site [chemical binding]; other site 226185006166 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 226185006167 domain I; other site 226185006168 DNA binding groove [nucleotide binding] 226185006169 phosphate binding site [ion binding]; other site 226185006170 domain II; other site 226185006171 domain III; other site 226185006172 nucleotide binding site [chemical binding]; other site 226185006173 catalytic site [active] 226185006174 domain IV; other site 226185006175 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 226185006176 Domain of unknown function (DUF4366); Region: DUF4366; pfam14283 226185006177 Domain of unknown function (DUF4315); Region: DUF4315; pfam14193 226185006178 Radical SAM superfamily; Region: Radical_SAM; pfam04055 226185006179 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 226185006180 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 226185006181 Peptidase family M23; Region: Peptidase_M23; pfam01551 226185006182 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 226185006183 NlpC/P60 family; Region: NLPC_P60; pfam00877 226185006184 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 226185006185 AAA-like domain; Region: AAA_10; pfam12846 226185006186 Domain of unknown function DUF87; Region: DUF87; cl19135 226185006187 Exotoxin A, targeting; Region: Exotox-A_target; pfam09102 226185006188 PrgI family protein; Region: PrgI; pfam12666 226185006189 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 226185006190 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 226185006191 putative active site [active] 226185006192 putative NTP binding site [chemical binding]; other site 226185006193 putative nucleic acid binding site [nucleotide binding]; other site 226185006194 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 226185006195 active site 226185006196 Maff2 family; Region: Maff2; pfam12750 226185006197 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 226185006198 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 226185006199 Walker A motif; other site 226185006200 ATP binding site [chemical binding]; other site 226185006201 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 226185006202 Walker B motif; other site 226185006203 Protein of unknown function (DUF3801); Region: DUF3801; pfam12687 226185006204 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 226185006205 Active Sites [active] 226185006206 Domain of unknown function (DUF3846); Region: DUF3846; pfam12957 226185006207 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 226185006208 Antirestriction protein (ArdA); Region: ArdA; pfam07275 226185006209 Protein of unknown function (DUF3789); Region: DUF3789; pfam12664 226185006210 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226185006211 non-specific DNA binding site [nucleotide binding]; other site 226185006212 salt bridge; other site 226185006213 sequence-specific DNA binding site [nucleotide binding]; other site 226185006214 Replication initiation factor; Region: Rep_trans; pfam02486 226185006215 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cl19095 226185006216 DNA binding site [nucleotide binding] 226185006217 substrate interaction site [chemical binding]; other site 226185006218 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226185006219 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 226185006220 Walker A motif; other site 226185006221 ATP binding site [chemical binding]; other site 226185006222 Walker B motif; other site 226185006223 arginine finger; other site 226185006224 RelB antitoxin; Region: RelB; cl01171 226185006225 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 226185006226 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 226185006227 Cna protein B-type domain; Region: Cna_B; pfam05738 226185006228 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 226185006229 Domain of unknown function DUF87; Region: DUF87; cl19135 226185006230 AAA-like domain; Region: AAA_10; pfam12846 226185006231 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226185006232 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226185006233 non-specific DNA binding site [nucleotide binding]; other site 226185006234 salt bridge; other site 226185006235 sequence-specific DNA binding site [nucleotide binding]; other site 226185006236 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226185006237 non-specific DNA binding site [nucleotide binding]; other site 226185006238 salt bridge; other site 226185006239 sequence-specific DNA binding site [nucleotide binding]; other site 226185006240 GTP-binding protein LepA; Provisional; Region: PRK05433 226185006241 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 226185006242 G1 box; other site 226185006243 putative GEF interaction site [polypeptide binding]; other site 226185006244 GTP/Mg2+ binding site [chemical binding]; other site 226185006245 Switch I region; other site 226185006246 G2 box; other site 226185006247 G3 box; other site 226185006248 Switch II region; other site 226185006249 G4 box; other site 226185006250 G5 box; other site 226185006251 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 226185006252 Elongation Factor G, domain II; Region: EFG_II; pfam14492 226185006253 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 226185006254 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 226185006255 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 226185006256 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 226185006257 Sterol carrier protein domain; Region: SCP2_2; pfam13530 226185006258 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 226185006259 Thylakoid formation protein; Region: ThylakoidFormat; cl12138 226185006260 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 226185006261 Clp amino terminal domain; Region: Clp_N; pfam02861 226185006262 Clp amino terminal domain; Region: Clp_N; pfam02861 226185006263 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226185006264 Walker A motif; other site 226185006265 ATP binding site [chemical binding]; other site 226185006266 Walker B motif; other site 226185006267 arginine finger; other site 226185006268 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226185006269 Walker A motif; other site 226185006270 ATP binding site [chemical binding]; other site 226185006271 Walker B motif; other site 226185006272 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 226185006273 DoxX; Region: DoxX; pfam07681 226185006274 Integrase core domain; Region: rve_3; cl15866 226185006275 adenylosuccinate lyase; Provisional; Region: PRK07492 226185006276 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 226185006277 tetramer interface [polypeptide binding]; other site 226185006278 active site 226185006279 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 226185006280 ATP-grasp domain; Region: ATP-grasp_4; cl17255 226185006281 Sulfate transporter family; Region: Sulfate_transp; cl19250 226185006282 xanthine permease; Region: pbuX; TIGR03173 226185006283 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 226185006284 active site 226185006285 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 226185006286 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 226185006287 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 226185006288 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 226185006289 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 226185006290 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 226185006291 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 226185006292 putative dimer interface [polypeptide binding]; other site 226185006293 putative anticodon binding site; other site 226185006294 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 226185006295 homodimer interface [polypeptide binding]; other site 226185006296 motif 1; other site 226185006297 motif 2; other site 226185006298 active site 226185006299 motif 3; other site 226185006300 aspartate aminotransferase; Provisional; Region: PRK05764 226185006301 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226185006302 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226185006303 homodimer interface [polypeptide binding]; other site 226185006304 catalytic residue [active] 226185006305 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 226185006306 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 226185006307 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 226185006308 active site 226185006309 catalytic site [active] 226185006310 substrate binding site [chemical binding]; other site 226185006311 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cd09708 226185006312 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 226185006313 inner membrane transporter YjeM; Provisional; Region: PRK15238 226185006314 DNA polymerase III PolC; Validated; Region: polC; PRK00448 226185006315 DNA polymerase III polC-type N-terminus I; Region: DNA_pol3_a_NI; pfam14480 226185006316 DNA polymerase III polC-type N-terminus II; Region: DNA_pol3_a_NII; pfam11490 226185006317 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 226185006318 generic binding surface II; other site 226185006319 generic binding surface I; other site 226185006320 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 226185006321 active site 226185006322 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 226185006323 active site 226185006324 catalytic site [active] 226185006325 substrate binding site [chemical binding]; other site 226185006326 putative PHP Thumb interface [polypeptide binding]; other site 226185006327 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 226185006328 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 226185006329 prolyl-tRNA synthetase; Provisional; Region: PRK09194 226185006330 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 226185006331 dimer interface [polypeptide binding]; other site 226185006332 motif 1; other site 226185006333 active site 226185006334 motif 2; other site 226185006335 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 226185006336 putative deacylase active site [active] 226185006337 motif 3; other site 226185006338 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 226185006339 anticodon binding site; other site 226185006340 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 226185006341 RIP metalloprotease RseP; Region: TIGR00054 226185006342 active site 226185006343 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 226185006344 protein binding site [polypeptide binding]; other site 226185006345 putative substrate binding region [chemical binding]; other site 226185006346 glucose-1-dehydrogenase; Provisional; Region: PRK08936 226185006347 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 226185006348 NAD binding site [chemical binding]; other site 226185006349 homodimer interface [polypeptide binding]; other site 226185006350 active site 226185006351 Predicted membrane protein [Function unknown]; Region: COG2364 226185006352 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 226185006353 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 226185006354 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 226185006355 P-loop; other site 226185006356 Magnesium ion binding site [ion binding]; other site 226185006357 FeS assembly protein SufB; Region: sufB; TIGR01980 226185006358 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 226185006359 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 226185006360 trimerization site [polypeptide binding]; other site 226185006361 active site 226185006362 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 226185006363 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 226185006364 catalytic residue [active] 226185006365 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 226185006366 FeS assembly protein SufD; Region: sufD; TIGR01981 226185006367 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 226185006368 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 226185006369 Walker A/P-loop; other site 226185006370 ATP binding site [chemical binding]; other site 226185006371 Q-loop/lid; other site 226185006372 ABC transporter signature motif; other site 226185006373 Walker B; other site 226185006374 D-loop; other site 226185006375 H-loop/switch region; other site 226185006376 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 226185006377 hinge region; other site 226185006378 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 226185006379 putative nucleotide binding site [chemical binding]; other site 226185006380 uridine monophosphate binding site [chemical binding]; other site 226185006381 homohexameric interface [polypeptide binding]; other site 226185006382 elongation factor Ts; Provisional; Region: tsf; PRK09377 226185006383 UBA/TS-N domain; Region: UBA; pfam00627 226185006384 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 226185006385 rRNA interaction site [nucleotide binding]; other site 226185006386 S8 interaction site; other site 226185006387 putative laminin-1 binding site; other site 226185006388 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 226185006389 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226185006390 Coenzyme A binding pocket [chemical binding]; other site 226185006391 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 226185006392 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 226185006393 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 226185006394 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 226185006395 OxaA-like protein precursor; Provisional; Region: PRK02463 226185006396 hypothetical protein; Provisional; Region: PRK07758 226185006397 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 226185006398 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 226185006399 DALR anticodon binding domain; Region: DALR_1; pfam05746 226185006400 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 226185006401 dimer interface [polypeptide binding]; other site 226185006402 motif 1; other site 226185006403 active site 226185006404 motif 2; other site 226185006405 motif 3; other site 226185006406 Recombination protein O N terminal; Region: RecO_N; pfam11967 226185006407 DNA repair protein RecO; Region: reco; TIGR00613 226185006408 Recombination protein O C terminal; Region: RecO_C; pfam02565 226185006409 GTPase Era; Reviewed; Region: era; PRK00089 226185006410 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 226185006411 G1 box; other site 226185006412 GTP/Mg2+ binding site [chemical binding]; other site 226185006413 Switch I region; other site 226185006414 G2 box; other site 226185006415 Switch II region; other site 226185006416 G3 box; other site 226185006417 G4 box; other site 226185006418 G5 box; other site 226185006419 KH domain; Region: KH_2; pfam07650 226185006420 Integral membrane undecaprenol kinase and similar enzymes; Region: UDPK_IM_like; cd14265 226185006421 trimer interface [polypeptide binding]; other site 226185006422 putative active site [active] 226185006423 Zn binding site [ion binding]; other site 226185006424 metal-binding heat shock protein; Provisional; Region: PRK00016 226185006425 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 226185006426 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 226185006427 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 226185006428 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 226185006429 Zn2+ binding site [ion binding]; other site 226185006430 Mg2+ binding site [ion binding]; other site 226185006431 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 226185006432 PhoH-like protein; Region: PhoH; pfam02562 226185006433 Yqey-like protein; Region: YqeY; pfam09424 226185006434 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 226185006435 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 226185006436 metal binding site 2 [ion binding]; metal-binding site 226185006437 putative DNA binding helix; other site 226185006438 metal binding site 1 [ion binding]; metal-binding site 226185006439 dimer interface [polypeptide binding]; other site 226185006440 structural Zn2+ binding site [ion binding]; other site 226185006441 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 226185006442 homoserine kinase; Provisional; Region: PRK01212 226185006443 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 226185006444 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 226185006445 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 226185006446 homodimer interface [polypeptide binding]; other site 226185006447 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226185006448 catalytic residue [active] 226185006449 homoserine dehydrogenase; Provisional; Region: PRK06349 226185006450 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 226185006451 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 226185006452 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 226185006453 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226185006454 dimerization interface [polypeptide binding]; other site 226185006455 putative DNA binding site [nucleotide binding]; other site 226185006456 putative Zn2+ binding site [ion binding]; other site 226185006457 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 226185006458 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 226185006459 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 226185006460 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 226185006461 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 226185006462 active site 226185006463 substrate binding site [chemical binding]; other site 226185006464 metal binding site [ion binding]; metal-binding site 226185006465 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 226185006466 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226185006467 DNA-binding site [nucleotide binding]; DNA binding site 226185006468 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226185006469 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226185006470 homodimer interface [polypeptide binding]; other site 226185006471 catalytic residue [active] 226185006472 PMP-22/EMP/MP20/Claudin tight junction; Region: Claudin_2; cl17758 226185006473 Transcriptional regulator PadR-like family; Region: PadR; cl17335 226185006474 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 226185006475 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 226185006476 active site 226185006477 Sulfate transporter family; Region: Sulfate_transp; cl19250 226185006478 xanthine permease; Region: pbuX; TIGR03173 226185006479 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 226185006480 guanine deaminase; Region: guan_deamin; TIGR02967 226185006481 active site 226185006482 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 226185006483 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 226185006484 catalytic core [active] 226185006485 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 226185006486 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 226185006487 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 226185006488 putative active site [active] 226185006489 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 226185006490 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 226185006491 active site turn [active] 226185006492 phosphorylation site [posttranslational modification] 226185006493 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 226185006494 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 226185006495 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 226185006496 putative active site [active] 226185006497 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 226185006498 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 226185006499 HPr interaction site; other site 226185006500 glycerol kinase (GK) interaction site [polypeptide binding]; other site 226185006501 active site 226185006502 phosphorylation site [posttranslational modification] 226185006503 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 226185006504 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 226185006505 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 226185006506 TIGR00153 family protein; Region: TIGR00153 226185006507 Phosphate transporter family; Region: PHO4; pfam01384 226185006508 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 226185006509 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 226185006510 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 226185006511 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 226185006512 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 226185006513 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 226185006514 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 226185006515 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 226185006516 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 226185006517 Competence protein; Region: Competence; pfam03772 226185006518 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 226185006519 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 226185006520 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 226185006521 catalytic motif [active] 226185006522 Zn binding site [ion binding]; other site 226185006523 SLBB domain; Region: SLBB; pfam10531 226185006524 comEA protein; Region: comE; TIGR01259 226185006525 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 226185006526 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 226185006527 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 226185006528 protein binding site [polypeptide binding]; other site 226185006529 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 226185006530 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 226185006531 active site 226185006532 (T/H)XGH motif; other site 226185006533 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226185006534 S-adenosylmethionine binding site [chemical binding]; other site 226185006535 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 226185006536 Protein of unknown function (DUF964); Region: DUF964; pfam06133 226185006537 CAP-associated N-terminal; Region: CAP_assoc_N; pfam14504 226185006538 pyruvate carboxylase; Reviewed; Region: PRK12999 226185006539 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 226185006540 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 226185006541 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 226185006542 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 226185006543 active site 226185006544 catalytic residues [active] 226185006545 metal binding site [ion binding]; metal-binding site 226185006546 homodimer binding site [polypeptide binding]; other site 226185006547 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 226185006548 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 226185006549 carboxyltransferase (CT) interaction site; other site 226185006550 biotinylation site [posttranslational modification]; other site 226185006551 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 226185006552 Protein of unknown function (DUF1507); Region: DUF1507; pfam07408 226185006553 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 226185006554 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226185006555 ATP binding site [chemical binding]; other site 226185006556 putative Mg++ binding site [ion binding]; other site 226185006557 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226185006558 nucleotide binding region [chemical binding]; other site 226185006559 ATP-binding site [chemical binding]; other site 226185006560 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 226185006561 HRDC domain; Region: HRDC; pfam00570 226185006562 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 226185006563 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 226185006564 G1 box; other site 226185006565 putative GEF interaction site [polypeptide binding]; other site 226185006566 GTP/Mg2+ binding site [chemical binding]; other site 226185006567 Switch I region; other site 226185006568 G2 box; other site 226185006569 G3 box; other site 226185006570 Switch II region; other site 226185006571 G4 box; other site 226185006572 G5 box; other site 226185006573 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 226185006574 Elongation Factor G, domain II; Region: EFG_II; pfam14492 226185006575 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 226185006576 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 226185006577 active site 226185006578 hypothetical protein; Provisional; Region: PRK04387 226185006579 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 226185006580 putative Cl- selectivity filter; other site 226185006581 putative pore gating glutamate residue; other site 226185006582 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226185006583 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 226185006584 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226185006585 Cna protein B-type domain; Region: Cna_B; pfam05738 226185006586 Cna protein B-type domain; Region: Cna_B; pfam05738 226185006587 Cna protein B-type domain; Region: Cna_B; pfam05738 226185006588 Cna protein B-type domain; Region: Cna_B; pfam05738 226185006589 Cna protein B-type domain; Region: Cna_B; pfam05738 226185006590 Cna protein B-type domain; Region: Cna_B; pfam05738 226185006591 Cna protein B-type domain; Region: Cna_B; pfam05738 226185006592 Cna protein B-type domain; Region: Cna_B; pfam05738 226185006593 Cna protein B-type domain; Region: Cna_B; pfam05738 226185006594 Cna protein B-type domain; Region: Cna_B; pfam05738 226185006595 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226185006596 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226185006597 non-specific DNA binding site [nucleotide binding]; other site 226185006598 salt bridge; other site 226185006599 sequence-specific DNA binding site [nucleotide binding]; other site 226185006600 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 226185006601 Zn2+ binding site [ion binding]; other site 226185006602 Mg2+ binding site [ion binding]; other site 226185006603 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 226185006604 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 226185006605 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 226185006606 active site 226185006607 HIGH motif; other site 226185006608 KMSK motif region; other site 226185006609 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 226185006610 tRNA binding surface [nucleotide binding]; other site 226185006611 anticodon binding site; other site 226185006612 UGMP family protein; Validated; Region: PRK09604 226185006613 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 226185006614 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 226185006615 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 226185006616 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226185006617 Coenzyme A binding pocket [chemical binding]; other site 226185006618 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 226185006619 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226185006620 Coenzyme A binding pocket [chemical binding]; other site 226185006621 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 226185006622 Glycoprotease family; Region: Peptidase_M22; pfam00814 226185006623 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 226185006624 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 226185006625 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 226185006626 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 226185006627 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 226185006628 Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like_u1; cd03408 226185006629 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 226185006630 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 226185006631 TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase; Region: TPM; pfam04536 226185006632 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 226185006633 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 226185006634 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 226185006635 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226185006636 motif II; other site 226185006637 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 226185006638 Ligand Binding Site [chemical binding]; other site 226185006639 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 226185006640 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 226185006641 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 226185006642 Walker A/P-loop; other site 226185006643 ATP binding site [chemical binding]; other site 226185006644 Q-loop/lid; other site 226185006645 ABC transporter signature motif; other site 226185006646 Walker B; other site 226185006647 D-loop; other site 226185006648 H-loop/switch region; other site 226185006649 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 226185006650 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 226185006651 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 226185006652 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 226185006653 UDP-galactopyranose mutase; Region: GLF; pfam03275 226185006654 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 226185006655 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 226185006656 FAD binding domain; Region: FAD_binding_4; pfam01565 226185006657 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 226185006658 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 226185006659 active site 226185006660 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 226185006661 active site 226185006662 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 226185006663 active site 226185006664 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 226185006665 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 226185006666 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 226185006667 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 226185006668 active site 226185006669 dimer interface [polypeptide binding]; other site 226185006670 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 226185006671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226185006672 dimer interface [polypeptide binding]; other site 226185006673 conserved gate region; other site 226185006674 putative PBP binding loops; other site 226185006675 ABC-ATPase subunit interface; other site 226185006676 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 226185006677 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 226185006678 Walker A/P-loop; other site 226185006679 ATP binding site [chemical binding]; other site 226185006680 Q-loop/lid; other site 226185006681 ABC transporter signature motif; other site 226185006682 Walker B; other site 226185006683 D-loop; other site 226185006684 H-loop/switch region; other site 226185006685 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 226185006686 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 226185006687 lipoyl attachment site [posttranslational modification]; other site 226185006688 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 226185006689 putative ArsC-like catalytic residues; other site 226185006690 putative TRX-like catalytic residues [active] 226185006691 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 226185006692 Mga helix-turn-helix domain; Region: Mga; pfam05043 226185006693 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 226185006694 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 226185006695 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 226185006696 Cna protein B-type domain; Region: Cna_B; pfam05738 226185006697 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 226185006698 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 226185006699 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 226185006700 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 226185006701 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 226185006702 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 226185006703 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 226185006704 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226185006705 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226185006706 non-specific DNA binding site [nucleotide binding]; other site 226185006707 salt bridge; other site 226185006708 sequence-specific DNA binding site [nucleotide binding]; other site 226185006709 Cupin domain; Region: Cupin_2; pfam07883 226185006710 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 226185006711 CHAP domain; Region: CHAP; cl17642 226185006712 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 226185006713 AAA-like domain; Region: AAA_10; pfam12846 226185006714 Domain of unknown function DUF87; Region: DUF87; cl19135 226185006715 TcpE family; Region: TcpE; pfam12648 226185006716 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 226185006717 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 226185006718 active site 226185006719 catalytic site [active] 226185006720 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 226185006721 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 226185006722 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226185006723 non-specific DNA binding site [nucleotide binding]; other site 226185006724 salt bridge; other site 226185006725 sequence-specific DNA binding site [nucleotide binding]; other site 226185006726 Replication initiation factor; Region: Rep_trans; pfam02486 226185006727 RNA polymerase sigma factor; Provisional; Region: PRK12518 226185006728 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 226185006729 Protein of unknown function DUF86; Region: DUF86; pfam01934 226185006730 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 226185006731 active site 226185006732 NTP binding site [chemical binding]; other site 226185006733 metal binding triad [ion binding]; metal-binding site 226185006734 antibiotic binding site [chemical binding]; other site 226185006735 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 226185006736 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 226185006737 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226185006738 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226185006739 non-specific DNA binding site [nucleotide binding]; other site 226185006740 salt bridge; other site 226185006741 sequence-specific DNA binding site [nucleotide binding]; other site 226185006742 Domain of unknown function (DUF955); Region: DUF955; cl01076 226185006743 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 226185006744 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 226185006745 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 226185006746 Int/Topo IB signature motif; other site 226185006747 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 226185006748 active site 226185006749 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 226185006750 dimer interface [polypeptide binding]; other site 226185006751 active site 226185006752 glycine-pyridoxal phosphate binding site [chemical binding]; other site 226185006753 folate binding site [chemical binding]; other site 226185006754 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 226185006755 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 226185006756 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 226185006757 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226185006758 S-adenosylmethionine binding site [chemical binding]; other site 226185006759 peptide chain release factor 1; Validated; Region: prfA; PRK00591 226185006760 This domain is found in peptide chain release factors; Region: PCRF; smart00937 226185006761 RF-1 domain; Region: RF-1; pfam00472 226185006762 thymidine kinase; Provisional; Region: PRK04296 226185006763 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 226185006764 L-aspartate oxidase; Provisional; Region: PRK06175 226185006765 Cation transport protein; Region: TrkH; cl17365 226185006766 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 226185006767 Cation transport protein; Region: TrkH; cl17365 226185006768 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 226185006769 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 226185006770 dimer interface [polypeptide binding]; other site 226185006771 PYR/PP interface [polypeptide binding]; other site 226185006772 TPP binding site [chemical binding]; other site 226185006773 substrate binding site [chemical binding]; other site 226185006774 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 226185006775 Domain of unknown function; Region: EKR; smart00890 226185006776 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 226185006777 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 226185006778 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 226185006779 TPP-binding site [chemical binding]; other site 226185006780 dimer interface [polypeptide binding]; other site 226185006781 putative oxidoreductase; Provisional; Region: PRK12831 226185006782 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 226185006783 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 226185006784 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 226185006785 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 226185006786 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 226185006787 FAD binding pocket [chemical binding]; other site 226185006788 FAD binding motif [chemical binding]; other site 226185006789 phosphate binding motif [ion binding]; other site 226185006790 beta-alpha-beta structure motif; other site 226185006791 NAD binding pocket [chemical binding]; other site 226185006792 Iron coordination center [ion binding]; other site 226185006793 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 226185006794 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 226185006795 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 226185006796 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 226185006797 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 226185006798 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 226185006799 CPxP motif; other site 226185006800 DsrE/DsrF-like family; Region: DrsE; pfam02635 226185006801 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 226185006802 Selenophosphate synthase [Amino acid transport and metabolism]; Region: SelD; COG0709 226185006803 dimerization interface [polypeptide binding]; other site 226185006804 putative ATP binding site [chemical binding]; other site 226185006805 cysteine desulfurase family protein; Region: am_tr_V_EF2568; TIGR01977 226185006806 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 226185006807 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 226185006808 catalytic residue [active] 226185006809 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 226185006810 Ligand binding site; other site 226185006811 metal-binding site 226185006812 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 226185006813 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 226185006814 catalytic loop [active] 226185006815 iron binding site [ion binding]; other site 226185006816 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 226185006817 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 226185006818 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 226185006819 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 226185006820 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 226185006821 XdhC Rossmann domain; Region: XdhC_C; pfam13478 226185006822 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 226185006823 Sulfate transporter family; Region: Sulfate_transp; cl19250 226185006824 xanthine permease; Region: pbuX; TIGR03173 226185006825 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 226185006826 homotrimer interaction site [polypeptide binding]; other site 226185006827 putative active site [active] 226185006828 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 226185006829 putative substrate binding site [chemical binding]; other site 226185006830 nucleotide binding site [chemical binding]; other site 226185006831 nucleotide binding site [chemical binding]; other site 226185006832 homodimer interface [polypeptide binding]; other site 226185006833 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 226185006834 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 226185006835 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 226185006836 putative selenium metabolism hydrolase; Region: selenium_YgeY; TIGR03526 226185006837 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 226185006838 putative metal binding site [ion binding]; other site 226185006839 putative dimer interface [polypeptide binding]; other site 226185006840 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 226185006841 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 226185006842 catalytic residue [active] 226185006843 D-hydantoinase; Region: D-hydantoinase; TIGR02033 226185006844 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 226185006845 tetramer interface [polypeptide binding]; other site 226185006846 active site 226185006847 putative selenate reductase, YgfK subunit; Region: Se_ygfK; TIGR03315 226185006848 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 226185006849 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 226185006850 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 226185006851 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 226185006852 putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314 226185006853 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 226185006854 active site 226185006855 putative substrate binding pocket [chemical binding]; other site 226185006856 YheO-like PAS domain; Region: PAS_6; pfam08348 226185006857 HTH domain; Region: HTH_22; pfam13309 226185006858 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 226185006859 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 226185006860 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 226185006861 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 226185006862 catalytic triad [active] 226185006863 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 226185006864 active site 226185006865 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 226185006866 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl19057 226185006867 Beta-lactamase; Region: Beta-lactamase; pfam00144 226185006868 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 226185006869 active site 226185006870 metal binding site [ion binding]; metal-binding site 226185006871 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 226185006872 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 226185006873 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 226185006874 Walker A/P-loop; other site 226185006875 ATP binding site [chemical binding]; other site 226185006876 Q-loop/lid; other site 226185006877 ABC transporter signature motif; other site 226185006878 Walker B; other site 226185006879 D-loop; other site 226185006880 H-loop/switch region; other site 226185006881 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 226185006882 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 226185006883 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226185006884 Walker A/P-loop; other site 226185006885 ATP binding site [chemical binding]; other site 226185006886 Q-loop/lid; other site 226185006887 ABC transporter signature motif; other site 226185006888 Walker B; other site 226185006889 D-loop; other site 226185006890 H-loop/switch region; other site 226185006891 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226185006892 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 226185006893 Guanylate kinase; Region: Guanylate_kin; pfam00625 226185006894 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 226185006895 catalytic site [active] 226185006896 G-X2-G-X-G-K; other site 226185006897 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 226185006898 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 226185006899 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 226185006900 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 226185006901 active site turn [active] 226185006902 phosphorylation site [posttranslational modification] 226185006903 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 226185006904 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 226185006905 HPr interaction site; other site 226185006906 glycerol kinase (GK) interaction site [polypeptide binding]; other site 226185006907 active site 226185006908 phosphorylation site [posttranslational modification] 226185006909 transcriptional antiterminator BglG; Provisional; Region: PRK09772 226185006910 CAT RNA binding domain; Region: CAT_RBD; smart01061 226185006911 PRD domain; Region: PRD; pfam00874 226185006912 PRD domain; Region: PRD; pfam00874 226185006913 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 226185006914 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 226185006915 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 226185006916 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 226185006917 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 226185006918 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 226185006919 hinge; other site 226185006920 active site 226185006921 conserved hypothetical integral membrane protein; Region: int_mem_ywzB; TIGR02327 226185006922 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 226185006923 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 226185006924 gamma subunit interface [polypeptide binding]; other site 226185006925 epsilon subunit interface [polypeptide binding]; other site 226185006926 LBP interface [polypeptide binding]; other site 226185006927 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 226185006928 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 226185006929 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 226185006930 alpha subunit interaction interface [polypeptide binding]; other site 226185006931 Walker A motif; other site 226185006932 ATP binding site [chemical binding]; other site 226185006933 Walker B motif; other site 226185006934 inhibitor binding site; inhibition site 226185006935 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 226185006936 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 226185006937 core domain interface [polypeptide binding]; other site 226185006938 delta subunit interface [polypeptide binding]; other site 226185006939 epsilon subunit interface [polypeptide binding]; other site 226185006940 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 226185006941 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 226185006942 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 226185006943 beta subunit interaction interface [polypeptide binding]; other site 226185006944 Walker A motif; other site 226185006945 ATP binding site [chemical binding]; other site 226185006946 Walker B motif; other site 226185006947 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 226185006948 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 226185006949 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 226185006950 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 226185006951 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 226185006952 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 226185006953 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 226185006954 SmpB-tmRNA interface; other site 226185006955 ribonuclease R; Region: RNase_R; TIGR02063 226185006956 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 226185006957 RNB domain; Region: RNB; pfam00773 226185006958 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 226185006959 RNA binding site [nucleotide binding]; other site 226185006960 Esterase/lipase [General function prediction only]; Region: COG1647 226185006961 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 226185006962 Preprotein translocase SecG subunit; Region: SecG; pfam03840 226185006963 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226185006964 Coenzyme A binding pocket [chemical binding]; other site 226185006965 Uncharacterized conserved protein [Function unknown]; Region: COG3592 226185006966 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 226185006967 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 226185006968 Soluble P-type ATPase [General function prediction only]; Region: COG4087 226185006969 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 226185006970 homodimer interface [polypeptide binding]; other site 226185006971 NAD binding pocket [chemical binding]; other site 226185006972 ATP binding pocket [chemical binding]; other site 226185006973 Mg binding site [ion binding]; other site 226185006974 active-site loop [active] 226185006975 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 226185006976 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 226185006977 active site 226185006978 GtrA-like protein; Region: GtrA; pfam04138 226185006979 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 226185006980 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 226185006981 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 226185006982 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 226185006983 ribonuclease Y; Region: RNase_Y; TIGR03319 226185006984 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226185006985 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 226185006986 DNA binding site [nucleotide binding] 226185006987 Transposase, Mutator family; Region: Transposase_mut; pfam00872 226185006988 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 226185006989 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 226185006990 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 226185006991 ring oligomerisation interface [polypeptide binding]; other site 226185006992 ATP/Mg binding site [chemical binding]; other site 226185006993 stacking interactions; other site 226185006994 hinge regions; other site 226185006995 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 226185006996 oligomerisation interface [polypeptide binding]; other site 226185006997 mobile loop; other site 226185006998 roof hairpin; other site 226185006999 CAAX protease self-immunity; Region: Abi; pfam02517 226185007000 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 226185007001 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 226185007002 CoA binding domain; Region: CoA_binding; pfam02629 226185007003 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 226185007004 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 226185007005 ABC transporter; Region: ABC_tran_2; pfam12848 226185007006 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 226185007007 HemX; Region: HemX; cl19375 226185007008 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 226185007009 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226185007010 DNA-binding site [nucleotide binding]; DNA binding site 226185007011 TrkA-C domain; Region: TrkA_C; pfam02080 226185007012 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 226185007013 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 226185007014 Walker A/P-loop; other site 226185007015 ATP binding site [chemical binding]; other site 226185007016 Q-loop/lid; other site 226185007017 ABC transporter signature motif; other site 226185007018 Walker B; other site 226185007019 D-loop; other site 226185007020 H-loop/switch region; other site 226185007021 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 226185007022 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226185007023 dimer interface [polypeptide binding]; other site 226185007024 conserved gate region; other site 226185007025 putative PBP binding loops; other site 226185007026 ABC-ATPase subunit interface; other site 226185007027 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 226185007028 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 226185007029 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 226185007030 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 226185007031 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 226185007032 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 226185007033 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 226185007034 glycerate kinase; Region: TIGR00045 226185007035 fructuronate transporter; Provisional; Region: PRK10034; cl15264 226185007036 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 226185007037 Uncharacterized conserved protein [Function unknown]; Region: COG0398 226185007038 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 226185007039 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 226185007040 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226185007041 dimer interface [polypeptide binding]; other site 226185007042 conserved gate region; other site 226185007043 putative PBP binding loops; other site 226185007044 ABC-ATPase subunit interface; other site 226185007045 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 226185007046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226185007047 dimer interface [polypeptide binding]; other site 226185007048 conserved gate region; other site 226185007049 putative PBP binding loops; other site 226185007050 ABC-ATPase subunit interface; other site 226185007051 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 226185007052 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 226185007053 Walker A/P-loop; other site 226185007054 ATP binding site [chemical binding]; other site 226185007055 Q-loop/lid; other site 226185007056 ABC transporter signature motif; other site 226185007057 Walker B; other site 226185007058 D-loop; other site 226185007059 H-loop/switch region; other site 226185007060 TOBE domain; Region: TOBE_2; pfam08402 226185007061 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226185007062 non-specific DNA binding site [nucleotide binding]; other site 226185007063 salt bridge; other site 226185007064 sequence-specific DNA binding site [nucleotide binding]; other site 226185007065 Cupin domain; Region: Cupin_2; pfam07883 226185007066 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 226185007067 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 226185007068 NADP binding site [chemical binding]; other site 226185007069 dimer interface [polypeptide binding]; other site 226185007070 phosphopantothenate--cysteine ligase, streptococcal; Region: coaB_strep; TIGR02114 226185007071 phosphopantothenoylcysteine decarboxylase, streptococcal; Region: coaC_strep; TIGR02113 226185007072 Predicted membrane protein [Function unknown]; Region: COG4684 226185007073 FemAB family; Region: FemAB; pfam02388 226185007074 QueT transporter; Region: QueT; pfam06177 226185007075 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 226185007076 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 226185007077 Surface antigen [General function prediction only]; Region: COG3942 226185007078 CHAP domain; Region: CHAP; cl17642 226185007079 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 226185007080 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 226185007081 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 226185007082 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 226185007083 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 226185007084 Helix-hairpin-helix containing domain; Region: HHH_4; pfam14490 226185007085 AAA domain; Region: AAA_30; pfam13604 226185007086 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 226185007087 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 226185007088 catalytic core [active] 226185007089 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 226185007090 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226185007091 S-adenosylmethionine binding site [chemical binding]; other site 226185007092 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 226185007093 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 226185007094 MgtE intracellular N domain; Region: MgtE_N; pfam03448 226185007095 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 226185007096 Divalent cation transporter; Region: MgtE; pfam01769 226185007097 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 226185007098 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 226185007099 synthetase active site [active] 226185007100 NTP binding site [chemical binding]; other site 226185007101 metal binding site [ion binding]; metal-binding site 226185007102 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 226185007103 putative active site [active] 226185007104 putative metal binding residues [ion binding]; other site 226185007105 signature motif; other site 226185007106 putative triphosphate binding site [ion binding]; other site 226185007107 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 226185007108 catalytic residues [active] 226185007109 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 226185007110 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 226185007111 active site 226185007112 Zn binding site [ion binding]; other site 226185007113 Competence protein CoiA-like family; Region: CoiA; pfam06054 226185007114 Negative regulator of genetic competence (MecA); Region: MecA; pfam05389 226185007115 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 226185007116 putative catalytic residues [active] 226185007117 thiol/disulfide switch; other site 226185007118 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 226185007119 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 226185007120 active site 226185007121 HIGH motif; other site 226185007122 dimer interface [polypeptide binding]; other site 226185007123 KMSKS motif; other site 226185007124 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 226185007125 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 226185007126 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226185007127 Walker A/P-loop; other site 226185007128 ATP binding site [chemical binding]; other site 226185007129 Q-loop/lid; other site 226185007130 ABC transporter signature motif; other site 226185007131 Walker B; other site 226185007132 D-loop; other site 226185007133 H-loop/switch region; other site 226185007134 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 226185007135 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 226185007136 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226185007137 motif II; other site 226185007138 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 226185007139 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 226185007140 WxL domain surface cell wall-binding; Region: WxL; pfam13731 226185007141 WxL domain surface cell wall-binding; Region: WxL; pfam13731 226185007142 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 226185007143 SWIM zinc finger; Region: SWIM; pfam04434 226185007144 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 226185007145 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 226185007146 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226185007147 ATP binding site [chemical binding]; other site 226185007148 putative Mg++ binding site [ion binding]; other site 226185007149 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226185007150 nucleotide binding region [chemical binding]; other site 226185007151 ATP-binding site [chemical binding]; other site 226185007152 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 226185007153 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226185007154 Walker A/P-loop; other site 226185007155 ATP binding site [chemical binding]; other site 226185007156 Q-loop/lid; other site 226185007157 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226185007158 ABC transporter signature motif; other site 226185007159 Walker B; other site 226185007160 D-loop; other site 226185007161 H-loop/switch region; other site 226185007162 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 226185007163 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 226185007164 active site 226185007165 metal binding site [ion binding]; metal-binding site 226185007166 DNA binding site [nucleotide binding] 226185007167 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 226185007168 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 226185007169 putative acyl-acceptor binding pocket; other site 226185007170 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 226185007171 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226185007172 S-adenosylmethionine binding site [chemical binding]; other site 226185007173 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 226185007174 GIY-YIG motif/motif A; other site 226185007175 putative active site [active] 226185007176 putative metal binding site [ion binding]; other site 226185007177 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 226185007178 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 226185007179 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 226185007180 dimer interface [polypeptide binding]; other site 226185007181 ADP-ribose binding site [chemical binding]; other site 226185007182 active site 226185007183 nudix motif; other site 226185007184 metal binding site [ion binding]; metal-binding site 226185007185 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 226185007186 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 226185007187 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 226185007188 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 226185007189 nudix motif; other site 226185007190 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 226185007191 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226185007192 Coenzyme A binding pocket [chemical binding]; other site 226185007193 Transcriptional regulator [Transcription]; Region: LytR; COG1316 226185007194 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 226185007195 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 226185007196 minor groove reading motif; other site 226185007197 helix-hairpin-helix signature motif; other site 226185007198 substrate binding pocket [chemical binding]; other site 226185007199 active site 226185007200 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 226185007201 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 226185007202 DNA binding and oxoG recognition site [nucleotide binding] 226185007203 recombination regulator RecX; Provisional; Region: recX; PRK14135 226185007204 TRAM domain; Region: TRAM; pfam01938 226185007205 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 226185007206 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226185007207 S-adenosylmethionine binding site [chemical binding]; other site 226185007208 Predicted membrane protein [Function unknown]; Region: COG2261 226185007209 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 226185007210 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 226185007211 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 226185007212 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 226185007213 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 226185007214 inner membrane transporter YjeM; Provisional; Region: PRK15238 226185007215 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 226185007216 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 226185007217 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226185007218 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226185007219 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 226185007220 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 226185007221 core dimer interface [polypeptide binding]; other site 226185007222 peripheral dimer interface [polypeptide binding]; other site 226185007223 L10 interface [polypeptide binding]; other site 226185007224 L11 interface [polypeptide binding]; other site 226185007225 putative EF-Tu interaction site [polypeptide binding]; other site 226185007226 putative EF-G interaction site [polypeptide binding]; other site 226185007227 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 226185007228 23S rRNA interface [nucleotide binding]; other site 226185007229 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 226185007230 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 226185007231 mRNA/rRNA interface [nucleotide binding]; other site 226185007232 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 226185007233 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 226185007234 23S rRNA interface [nucleotide binding]; other site 226185007235 L7/L12 interface [polypeptide binding]; other site 226185007236 putative thiostrepton binding site; other site 226185007237 L25 interface [polypeptide binding]; other site 226185007238 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 226185007239 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 226185007240 ABC transporter; Region: ABC_tran_2; pfam12848 226185007241 hypothetical protein; Provisional; Region: PRK06851 226185007242 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 226185007243 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 226185007244 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 226185007245 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 226185007246 putative L-serine binding site [chemical binding]; other site 226185007247 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 226185007248 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 226185007249 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_2; cd08769 226185007250 SxDxEG motif; other site 226185007251 putative active site [active] 226185007252 putative metal binding site [ion binding]; other site 226185007253 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 226185007254 oligomer interface [polypeptide binding]; other site 226185007255 active site 226185007256 metal binding site [ion binding]; metal-binding site 226185007257 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 226185007258 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 226185007259 peptide binding site [polypeptide binding]; other site 226185007260 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 226185007261 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 226185007262 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 226185007263 putative active site [active] 226185007264 Putative lysophospholipase; Region: Hydrolase_4; cl19140 226185007265 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 226185007266 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 226185007267 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 226185007268 putative homodimer interface [polypeptide binding]; other site 226185007269 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 226185007270 heterodimer interface [polypeptide binding]; other site 226185007271 homodimer interface [polypeptide binding]; other site 226185007272 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 226185007273 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 226185007274 FOG: CBS domain [General function prediction only]; Region: COG0517 226185007275 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 226185007276 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 226185007277 FAD binding domain; Region: FAD_binding_4; pfam01565 226185007278 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 226185007279 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 226185007280 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 226185007281 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 226185007282 active site 226185007283 putative catalytic site [active] 226185007284 DNA binding site [nucleotide binding] 226185007285 putative phosphate binding site [ion binding]; other site 226185007286 metal binding site A [ion binding]; metal-binding site 226185007287 AP binding site [nucleotide binding]; other site 226185007288 metal binding site B [ion binding]; metal-binding site 226185007289 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 226185007290 active site 226185007291 catalytic site [active] 226185007292 substrate binding site [chemical binding]; other site 226185007293 putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143 226185007294 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 226185007295 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 226185007296 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 226185007297 catalytic residue [active] 226185007298 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 226185007299 catalytic residues [active] 226185007300 peroxiredoxin; Region: AhpC; TIGR03137 226185007301 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 226185007302 dimer interface [polypeptide binding]; other site 226185007303 decamer (pentamer of dimers) interface [polypeptide binding]; other site 226185007304 catalytic triad [active] 226185007305 peroxidatic and resolving cysteines [active] 226185007306 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226185007307 S-adenosylmethionine binding site [chemical binding]; other site 226185007308 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 226185007309 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 226185007310 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 226185007311 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 226185007312 Protein of unknown function (DUF975); Region: DUF975; cl10504 226185007313 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 226185007314 oligomer interface [polypeptide binding]; other site 226185007315 active site 226185007316 metal binding site [ion binding]; metal-binding site 226185007317 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 226185007318 DltD N-terminal region; Region: DltD_N; pfam04915 226185007319 DltD central region; Region: DltD_M; pfam04918 226185007320 DltD C-terminal region; Region: DltD_C; pfam04914 226185007321 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 226185007322 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 226185007323 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 226185007324 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 226185007325 acyl-activating enzyme (AAE) consensus motif; other site 226185007326 AMP binding site [chemical binding]; other site 226185007327 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 226185007328 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 226185007329 FtsX-like permease family; Region: FtsX; pfam02687 226185007330 FtsX-like permease family; Region: FtsX; pfam02687 226185007331 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 226185007332 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 226185007333 Walker A/P-loop; other site 226185007334 ATP binding site [chemical binding]; other site 226185007335 Q-loop/lid; other site 226185007336 ABC transporter signature motif; other site 226185007337 Walker B; other site 226185007338 D-loop; other site 226185007339 H-loop/switch region; other site 226185007340 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 226185007341 ATP cone domain; Region: ATP-cone; pfam03477 226185007342 Class III ribonucleotide reductase; Region: RNR_III; cd01675 226185007343 effector binding site; other site 226185007344 active site 226185007345 Zn binding site [ion binding]; other site 226185007346 glycine loop; other site 226185007347 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 226185007348 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 226185007349 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 226185007350 active site 226185007351 DNA polymerase IV; Validated; Region: PRK02406 226185007352 DNA binding site [nucleotide binding] 226185007353 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 226185007354 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 226185007355 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226185007356 Walker A/P-loop; other site 226185007357 ATP binding site [chemical binding]; other site 226185007358 Q-loop/lid; other site 226185007359 ABC transporter signature motif; other site 226185007360 Walker B; other site 226185007361 D-loop; other site 226185007362 H-loop/switch region; other site 226185007363 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 226185007364 putative SAM binding site [chemical binding]; other site 226185007365 putative homodimer interface [polypeptide binding]; other site 226185007366 Protein of unknown function (DUF972); Region: DUF972; pfam06156 226185007367 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 226185007368 DNA polymerase III subunit delta'; Validated; Region: PRK08058 226185007369 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226185007370 Walker A motif; other site 226185007371 ATP binding site [chemical binding]; other site 226185007372 Walker B motif; other site 226185007373 arginine finger; other site 226185007374 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870 226185007375 thymidylate kinase; Validated; Region: tmk; PRK00698 226185007376 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 226185007377 TMP-binding site; other site 226185007378 ATP-binding site [chemical binding]; other site 226185007379 recombination protein RecR; Reviewed; Region: recR; PRK00076 226185007380 RecR protein; Region: RecR; pfam02132 226185007381 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 226185007382 putative active site [active] 226185007383 putative metal-binding site [ion binding]; other site 226185007384 tetramer interface [polypeptide binding]; other site 226185007385 Putative transcription activator [Transcription]; Region: TenA; COG0819 226185007386 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 226185007387 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 226185007388 Walker A/P-loop; other site 226185007389 ATP binding site [chemical binding]; other site 226185007390 Q-loop/lid; other site 226185007391 ABC transporter signature motif; other site 226185007392 Walker B; other site 226185007393 D-loop; other site 226185007394 H-loop/switch region; other site 226185007395 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 226185007396 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 226185007397 Walker A/P-loop; other site 226185007398 ATP binding site [chemical binding]; other site 226185007399 Q-loop/lid; other site 226185007400 ABC transporter signature motif; other site 226185007401 Walker B; other site 226185007402 D-loop; other site 226185007403 H-loop/switch region; other site 226185007404 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 226185007405 TraX protein; Region: TraX; cl05434 226185007406 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 226185007407 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226185007408 putative substrate translocation pore; other site 226185007409 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226185007410 putative DNA binding site [nucleotide binding]; other site 226185007411 putative Zn2+ binding site [ion binding]; other site 226185007412 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 226185007413 dimer interface [polypeptide binding]; other site 226185007414 substrate binding site [chemical binding]; other site 226185007415 ATP binding site [chemical binding]; other site 226185007416 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 226185007417 thiamine phosphate binding site [chemical binding]; other site 226185007418 active site 226185007419 pyrophosphate binding site [ion binding]; other site 226185007420 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 226185007421 substrate binding site [chemical binding]; other site 226185007422 multimerization interface [polypeptide binding]; other site 226185007423 ATP binding site [chemical binding]; other site 226185007424 thiW protein; Region: thiW; TIGR02359 226185007425 hypothetical protein; Validated; Region: PRK00153 226185007426 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 226185007427 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226185007428 Walker A motif; other site 226185007429 ATP binding site [chemical binding]; other site 226185007430 Walker B motif; other site 226185007431 arginine finger; other site 226185007432 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 226185007433 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 226185007434 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 226185007435 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 226185007436 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 226185007437 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 226185007438 NAD binding site [chemical binding]; other site 226185007439 homodimer interface [polypeptide binding]; other site 226185007440 active site 226185007441 substrate binding site [chemical binding]; other site 226185007442 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 226185007443 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 226185007444 Uncharacterized conserved protein [Function unknown]; Region: COG3189 226185007445 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 226185007446 active site residue [active] 226185007447 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 226185007448 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 226185007449 nucleotide binding site [chemical binding]; other site 226185007450 Glucokinase; Region: Glucokinase; cl17310 226185007451 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 226185007452 Rhomboid family; Region: Rhomboid; pfam01694 226185007453 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 226185007454 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 226185007455 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 226185007456 Protein of unknown function (DUF805); Region: DUF805; pfam05656 226185007457 conserved hypothetical integral membrane protein; Region: TIGR03766 226185007458 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 226185007459 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 226185007460 PHAGE06, prophage. 226185007461 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 226185007462 Transposase, Mutator family; Region: Transposase_mut; cl19537 226185007463 Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415 226185007464 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 226185007465 active site 226185007466 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 226185007467 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 226185007468 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 226185007469 Haemolysin XhlA; Region: XhlA; pfam10779 226185007470 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 226185007471 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 226185007472 Prophage endopeptidase tail; Region: Prophage_tail; cl19379 226185007473 Phage tail protein; Region: Sipho_tail; cl17486 226185007474 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 226185007475 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 226185007476 Phage-related protein [Function unknown]; Region: COG5412 226185007477 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 226185007478 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 226185007479 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 226185007480 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 226185007481 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 226185007482 oligomerization interface [polypeptide binding]; other site 226185007483 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 226185007484 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 226185007485 Phage capsid family; Region: Phage_capsid; pfam05065 226185007486 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 226185007487 Phage portal protein; Region: Phage_portal; cl19194 226185007488 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 226185007489 Phage Terminase; Region: Terminase_1; cl19862 226185007490 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 226185007491 active site 226185007492 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 226185007493 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 226185007494 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 226185007495 Domain of unknown function (DUF4393); Region: DUF4393; pfam14337 226185007496 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 226185007497 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 226185007498 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226185007499 Walker A motif; other site 226185007500 ATP binding site [chemical binding]; other site 226185007501 Walker B motif; other site 226185007502 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 226185007503 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 226185007504 DNA-binding site [nucleotide binding]; DNA binding site 226185007505 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 226185007506 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 226185007507 RecT family; Region: RecT; pfam03837 226185007508 Helix-turn-helix domain; Region: HTH_17; pfam12728 226185007509 Helix-turn-helix domain; Region: HTH_31; pfam13560 226185007510 non-specific DNA binding site [nucleotide binding]; other site 226185007511 salt bridge; other site 226185007512 sequence-specific DNA binding site [nucleotide binding]; other site 226185007513 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 226185007514 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 226185007515 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226185007516 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226185007517 non-specific DNA binding site [nucleotide binding]; other site 226185007518 salt bridge; other site 226185007519 sequence-specific DNA binding site [nucleotide binding]; other site 226185007520 Domain of unknown function (DUF955); Region: DUF955; cl01076 226185007521 Ion transport protein; Region: Ion_trans; pfam00520 226185007522 Ion channel; Region: Ion_trans_2; pfam07885 226185007523 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 226185007524 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 226185007525 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 226185007526 Int/Topo IB signature motif; other site 226185007527 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 226185007528 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 226185007529 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 226185007530 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 226185007531 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 226185007532 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 226185007533 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 226185007534 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 226185007535 active site 226185007536 dimer interface [polypeptide binding]; other site 226185007537 motif 1; other site 226185007538 motif 2; other site 226185007539 motif 3; other site 226185007540 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 226185007541 anticodon binding site; other site 226185007542 4-oxalocrotonate tautomerase; Provisional; Region: PRK02220 226185007543 active site 1 [active] 226185007544 dimer interface [polypeptide binding]; other site 226185007545 hexamer interface [polypeptide binding]; other site 226185007546 active site 2 [active] 226185007547 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 226185007548 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 226185007549 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 226185007550 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 226185007551 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 226185007552 putative active site [active] 226185007553 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 226185007554 active site 226185007555 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 226185007556 hypothetical protein; Provisional; Region: PRK12378 226185007557 hypothetical protein; Provisional; Region: PRK13670 226185007558 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 226185007559 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226185007560 S-adenosylmethionine binding site [chemical binding]; other site 226185007561 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 226185007562 Zn2+ binding site [ion binding]; other site 226185007563 Mg2+ binding site [ion binding]; other site 226185007564 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 226185007565 active site 226185007566 (T/H)XGH motif; other site 226185007567 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 226185007568 GTPase YqeH; Provisional; Region: PRK13796 226185007569 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 226185007570 GTP/Mg2+ binding site [chemical binding]; other site 226185007571 G4 box; other site 226185007572 G5 box; other site 226185007573 G1 box; other site 226185007574 Switch I region; other site 226185007575 G2 box; other site 226185007576 G3 box; other site 226185007577 Switch II region; other site 226185007578 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226185007579 active site 226185007580 motif I; other site 226185007581 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 226185007582 motif II; other site 226185007583 acetyl-CoA carboxylase subunit alpha; Provisional; Region: PRK12319 226185007584 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 226185007585 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 226185007586 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 226185007587 ATP-grasp domain; Region: ATP-grasp_4; cl17255 226185007588 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 226185007589 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 226185007590 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 226185007591 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 226185007592 carboxyltransferase (CT) interaction site; other site 226185007593 biotinylation site [posttranslational modification]; other site 226185007594 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 226185007595 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 226185007596 dimer interface [polypeptide binding]; other site 226185007597 active site 226185007598 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 226185007599 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 226185007600 NAD(P) binding site [chemical binding]; other site 226185007601 homotetramer interface [polypeptide binding]; other site 226185007602 homodimer interface [polypeptide binding]; other site 226185007603 active site 226185007604 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 226185007605 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 226185007606 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 226185007607 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 226185007608 FMN binding site [chemical binding]; other site 226185007609 substrate binding site [chemical binding]; other site 226185007610 putative catalytic residue [active] 226185007611 acyl carrier protein; Provisional; Region: acpP; PRK00982 226185007612 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 226185007613 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 226185007614 dimer interface [polypeptide binding]; other site 226185007615 active site 226185007616 CoA binding pocket [chemical binding]; other site 226185007617 Transcriptional regulators [Transcription]; Region: MarR; COG1846 226185007618 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 226185007619 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 226185007620 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 226185007621 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 226185007622 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 226185007623 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 226185007624 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 226185007625 putative ADP-binding pocket [chemical binding]; other site 226185007626 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 226185007627 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 226185007628 general stress protein 13; Validated; Region: PRK08059 226185007629 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 226185007630 RNA binding site [nucleotide binding]; other site 226185007631 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 226185007632 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226185007633 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226185007634 homodimer interface [polypeptide binding]; other site 226185007635 catalytic residue [active] 226185007636 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 226185007637 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 226185007638 active site 226185007639 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 226185007640 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 226185007641 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 226185007642 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 226185007643 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 226185007644 putative ligand binding site [chemical binding]; other site 226185007645 NAD binding site [chemical binding]; other site 226185007646 catalytic site [active] 226185007647 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 226185007648 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 226185007649 active site 226185007650 metal binding site [ion binding]; metal-binding site 226185007651 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 226185007652 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 226185007653 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 226185007654 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 226185007655 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 226185007656 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 226185007657 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226185007658 dimer interface [polypeptide binding]; other site 226185007659 conserved gate region; other site 226185007660 putative PBP binding loops; other site 226185007661 ABC-ATPase subunit interface; other site 226185007662 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 226185007663 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226185007664 dimer interface [polypeptide binding]; other site 226185007665 conserved gate region; other site 226185007666 putative PBP binding loops; other site 226185007667 ABC-ATPase subunit interface; other site 226185007668 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 226185007669 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226185007670 Walker A/P-loop; other site 226185007671 ATP binding site [chemical binding]; other site 226185007672 Q-loop/lid; other site 226185007673 ABC transporter signature motif; other site 226185007674 Walker B; other site 226185007675 D-loop; other site 226185007676 H-loop/switch region; other site 226185007677 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 226185007678 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 226185007679 Ligand binding site; other site 226185007680 Putative Catalytic site; other site 226185007681 DXD motif; other site 226185007682 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 226185007683 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 226185007684 TrkA-N domain; Region: TrkA_N; pfam02254 226185007685 TrkA-C domain; Region: TrkA_C; pfam02080 226185007686 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 226185007687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226185007688 active site 226185007689 phosphorylation site [posttranslational modification] 226185007690 intermolecular recognition site; other site 226185007691 dimerization interface [polypeptide binding]; other site 226185007692 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 226185007693 DNA binding residues [nucleotide binding] 226185007694 dimerization interface [polypeptide binding]; other site 226185007695 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 226185007696 Histidine kinase; Region: HisKA_3; pfam07730 226185007697 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226185007698 ATP binding site [chemical binding]; other site 226185007699 Mg2+ binding site [ion binding]; other site 226185007700 G-X-G motif; other site 226185007701 UbiA family of prenyltransferases (PTases); Region: PT_UbiA; cl00337 226185007702 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 226185007703 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 226185007704 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 226185007705 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 226185007706 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 226185007707 dimerization interface [polypeptide binding]; other site 226185007708 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 226185007709 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226185007710 active site 226185007711 motif I; other site 226185007712 motif II; other site 226185007713 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 226185007714 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 226185007715 active site 226185007716 homodimer interface [polypeptide binding]; other site 226185007717 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 226185007718 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 226185007719 trimer interface [polypeptide binding]; other site 226185007720 putative metal binding site [ion binding]; other site 226185007721 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 226185007722 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 226185007723 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 226185007724 Walker A/P-loop; other site 226185007725 ATP binding site [chemical binding]; other site 226185007726 Q-loop/lid; other site 226185007727 ABC transporter signature motif; other site 226185007728 Walker B; other site 226185007729 D-loop; other site 226185007730 H-loop/switch region; other site 226185007731 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 226185007732 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 226185007733 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226185007734 Walker A/P-loop; other site 226185007735 ATP binding site [chemical binding]; other site 226185007736 Q-loop/lid; other site 226185007737 ABC transporter signature motif; other site 226185007738 Walker B; other site 226185007739 D-loop; other site 226185007740 H-loop/switch region; other site 226185007741 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 226185007742 Protein of unknown function (DUF1447); Region: DUF1447; pfam07288 226185007743 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 226185007744 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 226185007745 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 226185007746 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 226185007747 DNA-binding site [nucleotide binding]; DNA binding site 226185007748 RNA-binding motif; other site 226185007749 hypothetical protein; Reviewed; Region: PRK00024 226185007750 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 226185007751 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 226185007752 MPN+ (JAMM) motif; other site 226185007753 Zinc-binding site [ion binding]; other site 226185007754 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 226185007755 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 226185007756 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226185007757 motif II; other site 226185007758 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 226185007759 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 226185007760 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 226185007761 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 226185007762 Uncharacterized conserved protein [Function unknown]; Region: COG0398 226185007763 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 226185007764 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 226185007765 active site 226185007766 HIGH motif; other site 226185007767 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 226185007768 KMSKS motif; other site 226185007769 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 226185007770 tRNA binding surface [nucleotide binding]; other site 226185007771 anticodon binding site; other site 226185007772 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 226185007773 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 226185007774 dimer interface [polypeptide binding]; other site 226185007775 catalytic triad [active] 226185007776 peroxidatic and resolving cysteines [active] 226185007777 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 226185007778 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 226185007779 CoA binding domain; Region: CoA_binding; pfam02629 226185007780 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 226185007781 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 226185007782 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 226185007783 Ligand Binding Site [chemical binding]; other site 226185007784 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 226185007785 PHAGE07, prophage. 226185007786 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 226185007787 DNA-binding site [nucleotide binding]; DNA binding site 226185007788 RNA-binding motif; other site 226185007789 V-type ATPase 116kDa subunit family; Region: V_ATPase_I; pfam01496 226185007790 Protein of unknown function (DUF3206); Region: DUF3206; pfam11472 226185007791 D5 N terminal like; Region: D5_N; smart00885 226185007792 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 226185007793 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 226185007794 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 226185007795 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226185007796 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226185007797 non-specific DNA binding site [nucleotide binding]; other site 226185007798 salt bridge; other site 226185007799 sequence-specific DNA binding site [nucleotide binding]; other site 226185007800 AP2-like DNA-binding integrase domain; Region: Integrase_AP2; pfam14657 226185007801 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 226185007802 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 226185007803 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 226185007804 Int/Topo IB signature motif; other site 226185007805 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 226185007806 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226185007807 NAD(P) binding site [chemical binding]; other site 226185007808 active site 226185007809 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 226185007810 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 226185007811 putative trimer interface [polypeptide binding]; other site 226185007812 putative CoA binding site [chemical binding]; other site 226185007813 Transcriptional regulator [Transcription]; Region: LysR; COG0583 226185007814 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 226185007815 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 226185007816 dimerization interface [polypeptide binding]; other site 226185007817 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 226185007818 Sugar transport protein; Region: Sugar_transport; pfam06800 226185007819 D-ribose pyranase; Provisional; Region: PRK11797 226185007820 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 226185007821 substrate binding site [chemical binding]; other site 226185007822 dimer interface [polypeptide binding]; other site 226185007823 ATP binding site [chemical binding]; other site 226185007824 Transcriptional regulators [Transcription]; Region: PurR; COG1609 226185007825 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 226185007826 DNA binding site [nucleotide binding] 226185007827 domain linker motif; other site 226185007828 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 226185007829 dimerization interface [polypeptide binding]; other site 226185007830 ligand binding site [chemical binding]; other site 226185007831 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 226185007832 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 226185007833 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 226185007834 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 226185007835 active site 226185007836 P-loop; other site 226185007837 phosphorylation site [posttranslational modification] 226185007838 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 226185007839 PRD domain; Region: PRD; pfam00874 226185007840 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 226185007841 active site 226185007842 P-loop; other site 226185007843 phosphorylation site [posttranslational modification] 226185007844 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 226185007845 active site 226185007846 phosphorylation site [posttranslational modification] 226185007847 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 226185007848 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 226185007849 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 226185007850 WxL domain surface cell wall-binding; Region: WxL; pfam13731 226185007851 Amidinotransferase; Region: Amidinotransf; cl19186 226185007852 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 226185007853 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 226185007854 dimer interface [polypeptide binding]; other site 226185007855 active site 226185007856 MutS domain III; Region: MutS_III; pfam05192 226185007857 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226185007858 Walker A/P-loop; other site 226185007859 ATP binding site [chemical binding]; other site 226185007860 Q-loop/lid; other site 226185007861 ABC transporter signature motif; other site 226185007862 Walker B; other site 226185007863 D-loop; other site 226185007864 H-loop/switch region; other site 226185007865 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 226185007866 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 226185007867 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 226185007868 catalytic residue [active] 226185007869 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 226185007870 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 226185007871 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 226185007872 active site 226185007873 phosphorylation site [posttranslational modification] 226185007874 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 226185007875 active pocket/dimerization site; other site 226185007876 active site 226185007877 phosphorylation site [posttranslational modification] 226185007878 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 226185007879 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226185007880 Walker A motif; other site 226185007881 ATP binding site [chemical binding]; other site 226185007882 Walker B motif; other site 226185007883 arginine finger; other site 226185007884 PRD domain; Region: PRD; pfam00874 226185007885 Transcriptional antiterminator [Transcription]; Region: COG3933 226185007886 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 226185007887 active pocket/dimerization site; other site 226185007888 active site 226185007889 phosphorylation site [posttranslational modification] 226185007890 PRD domain; Region: PRD; pfam00874 226185007891 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 226185007892 catalytic core [active] 226185007893 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951 226185007894 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 226185007895 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 226185007896 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 226185007897 FtsX-like permease family; Region: FtsX; pfam02687 226185007898 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 226185007899 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 226185007900 Walker A/P-loop; other site 226185007901 ATP binding site [chemical binding]; other site 226185007902 Q-loop/lid; other site 226185007903 ABC transporter signature motif; other site 226185007904 Walker B; other site 226185007905 D-loop; other site 226185007906 H-loop/switch region; other site 226185007907 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 226185007908 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 226185007909 HlyD family secretion protein; Region: HlyD_3; pfam13437 226185007910 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 226185007911 active site residue [active] 226185007912 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 226185007913 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 226185007914 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 226185007915 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 226185007916 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 226185007917 active site residue [active] 226185007918 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 226185007919 active site residue [active] 226185007920 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 226185007921 putative homodimer interface [polypeptide binding]; other site 226185007922 putative homotetramer interface [polypeptide binding]; other site 226185007923 putative metal binding site [ion binding]; other site 226185007924 putative homodimer-homodimer interface [polypeptide binding]; other site 226185007925 putative allosteric switch controlling residues; other site 226185007926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226185007927 D-galactonate transporter; Region: 2A0114; TIGR00893 226185007928 putative substrate translocation pore; other site 226185007929 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 226185007930 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 226185007931 catalytic residue [active] 226185007932 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 226185007933 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 226185007934 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 226185007935 putative allantoin catabolism protein; Region: ura-cupin; TIGR03214 226185007936 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 226185007937 Cupin domain; Region: Cupin_2; cl17218 226185007938 allantoate amidohydrolase; Region: AllC; TIGR03176 226185007939 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 226185007940 active site 226185007941 metal binding site [ion binding]; metal-binding site 226185007942 dimer interface [polypeptide binding]; other site 226185007943 allantoinase; Provisional; Region: PRK08044 226185007944 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 226185007945 active site 226185007946 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 226185007947 Na binding site [ion binding]; other site 226185007948 putative substrate binding site [chemical binding]; other site 226185007949 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 226185007950 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226185007951 Coenzyme A binding pocket [chemical binding]; other site 226185007952 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 226185007953 Transcriptional regulators [Transcription]; Region: MarR; COG1846 226185007954 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 226185007955 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 226185007956 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 226185007957 Sulfate transporter family; Region: Sulfate_transp; pfam00916 226185007958 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 226185007959 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 226185007960 active site 226185007961 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49); Region: G6PD_bact; pfam10786 226185007962 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 226185007963 Cl- selectivity filter; other site 226185007964 Cl- binding residues [ion binding]; other site 226185007965 pore gating glutamate residue; other site 226185007966 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 226185007967 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 226185007968 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 226185007969 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 226185007970 CoA binding domain; Region: CoA_binding; pfam02629 226185007971 CoA-ligase; Region: Ligase_CoA; pfam00549 226185007972 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 226185007973 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 226185007974 Mga helix-turn-helix domain; Region: Mga; pfam05043 226185007975 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 226185007976 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 226185007977 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 226185007978 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 226185007979 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 226185007980 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 226185007981 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 226185007982 serine/threonine transporter SstT; Provisional; Region: PRK13628 226185007983 Ion channel; Region: Ion_trans_2; pfam07885 226185007984 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 226185007985 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 226185007986 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 226185007987 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226185007988 DNA binding residues [nucleotide binding] 226185007989 DinB superfamily; Region: DinB_2; pfam12867 226185007990 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 226185007991 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 226185007992 sugar binding site [chemical binding]; other site 226185007993 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 226185007994 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 226185007995 substrate binding site [chemical binding]; other site 226185007996 catalytic residues [active] 226185007997 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 226185007998 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 226185007999 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 226185008000 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 226185008001 protein binding site [polypeptide binding]; other site 226185008002 Domain of unknown function (DUF4479); Region: DUF4479; pfam14794 226185008003 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 226185008004 putative tRNA-binding site [nucleotide binding]; other site 226185008005 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 226185008006 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 226185008007 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 226185008008 active site 226185008009 phosphorylation site [posttranslational modification] 226185008010 BtpA family; Region: BtpA; cl00440 226185008011 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 226185008012 active pocket/dimerization site; other site 226185008013 active site 226185008014 phosphorylation site [posttranslational modification] 226185008015 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 226185008016 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226185008017 DNA-binding site [nucleotide binding]; DNA binding site 226185008018 UTRA domain; Region: UTRA; pfam07702 226185008019 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 226185008020 Ligand Binding Site [chemical binding]; other site 226185008021 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 226185008022 catalytic residues [active] 226185008023 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 226185008024 oligomer interface [polypeptide binding]; other site 226185008025 active site 226185008026 metal binding site [ion binding]; metal-binding site 226185008027 Predicted small secreted protein [Function unknown]; Region: COG5584 226185008028 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 226185008029 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 226185008030 peptide binding site [polypeptide binding]; other site 226185008031 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 226185008032 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 226185008033 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 226185008034 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 226185008035 active site 226185008036 dimer interface [polypeptide binding]; other site 226185008037 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 226185008038 active site 226185008039 phosphorylation site [posttranslational modification] 226185008040 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 226185008041 active pocket/dimerization site; other site 226185008042 active site 226185008043 phosphorylation site [posttranslational modification] 226185008044 Acyltransferase family; Region: Acyl_transf_3; cl19154 226185008045 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 226185008046 putative active site [active] 226185008047 YdjC motif; other site 226185008048 Mg binding site [ion binding]; other site 226185008049 putative homodimer interface [polypeptide binding]; other site 226185008050 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 226185008051 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 226185008052 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 226185008053 putative active site [active] 226185008054 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 226185008055 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 226185008056 putative active site [active] 226185008057 putative proton-coupled thiamine transporter YuaJ; Region: thia_yuaJ; TIGR02357 226185008058 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 226185008059 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 226185008060 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 226185008061 active site 226185008062 catalytic site [active] 226185008063 Low molecular weight phosphatase family; Region: LMWPc; cd00115 226185008064 active site 226185008065 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 226185008066 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 226185008067 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 226185008068 Syntaxin; Region: Syntaxin; cl00143 226185008069 CHAP domain; Region: CHAP; cl17642 226185008070 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 226185008071 rod shape-determining protein MreC; Provisional; Region: PRK13922 226185008072 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 226185008073 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 226185008074 RNase E interface [polypeptide binding]; other site 226185008075 trimer interface [polypeptide binding]; other site 226185008076 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 226185008077 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 226185008078 RNase E interface [polypeptide binding]; other site 226185008079 trimer interface [polypeptide binding]; other site 226185008080 active site 226185008081 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 226185008082 putative nucleic acid binding region [nucleotide binding]; other site 226185008083 G-X-X-G motif; other site 226185008084 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 226185008085 RNA binding site [nucleotide binding]; other site 226185008086 domain interface; other site 226185008087 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 226185008088 16S/18S rRNA binding site [nucleotide binding]; other site 226185008089 S13e-L30e interaction site [polypeptide binding]; other site 226185008090 25S rRNA binding site [nucleotide binding]; other site 226185008091 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 226185008092 active site 226185008093 catalytic residues [active] 226185008094 metal binding site [ion binding]; metal-binding site 226185008095 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226185008096 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 226185008097 active site 226185008098 motif I; other site 226185008099 motif II; other site 226185008100 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 226185008101 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 226185008102 active site 226185008103 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 226185008104 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 226185008105 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 226185008106 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 226185008107 RNA binding surface [nucleotide binding]; other site 226185008108 BioY family; Region: BioY; pfam02632 226185008109 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 226185008110 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 226185008111 Catalytic site [active] 226185008112 WxL domain surface cell wall-binding; Region: WxL; pfam13731 226185008113 WxL domain surface cell wall-binding; Region: WxL; pfam13731 226185008114 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 226185008115 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 226185008116 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 226185008117 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 226185008118 peptidase T-like protein; Region: PepT-like; TIGR01883 226185008119 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 226185008120 metal binding site [ion binding]; metal-binding site 226185008121 dimer interface [polypeptide binding]; other site 226185008122 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 226185008123 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 226185008124 peptide binding site [polypeptide binding]; other site 226185008125 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 226185008126 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 226185008127 putative ligand binding residues [chemical binding]; other site 226185008128 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 226185008129 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 226185008130 Walker A/P-loop; other site 226185008131 ATP binding site [chemical binding]; other site 226185008132 Q-loop/lid; other site 226185008133 ABC transporter signature motif; other site 226185008134 Walker B; other site 226185008135 D-loop; other site 226185008136 H-loop/switch region; other site 226185008137 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 226185008138 ABC-ATPase subunit interface; other site 226185008139 dimer interface [polypeptide binding]; other site 226185008140 putative PBP binding regions; other site 226185008141 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 226185008142 ABC-ATPase subunit interface; other site 226185008143 dimer interface [polypeptide binding]; other site 226185008144 putative PBP binding regions; other site 226185008145 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 226185008146 glutamate--cysteine ligase/gamma-glutamylcysteine synthetase, Streptococcus agalactiae type; Region: glu_cys_lig_rel; TIGR01435 226185008147 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 226185008148 ATP-grasp domain; Region: ATP-grasp_4; cl17255 226185008149 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 226185008150 catalytic triad [active] 226185008151 conserved cis-peptide bond; other site 226185008152 Uncharacterized conserved protein [Function unknown]; Region: COG1284 226185008153 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 226185008154 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 226185008155 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 226185008156 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 226185008157 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 226185008158 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 226185008159 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 226185008160 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 226185008161 P loop; other site 226185008162 GTP binding site [chemical binding]; other site 226185008163 sugar phosphate phosphatase; Provisional; Region: PRK10513 226185008164 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226185008165 active site 226185008166 motif I; other site 226185008167 motif II; other site 226185008168 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 226185008169 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 226185008170 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 226185008171 Walker A/P-loop; other site 226185008172 ATP binding site [chemical binding]; other site 226185008173 Q-loop/lid; other site 226185008174 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 226185008175 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 226185008176 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 226185008177 HemX; Region: HemX; cl19375 226185008178 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 226185008179 ABC transporter signature motif; other site 226185008180 Walker B; other site 226185008181 D-loop; other site 226185008182 H-loop/switch region; other site 226185008183 ribonuclease III; Reviewed; Region: rnc; PRK00102 226185008184 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 226185008185 dimerization interface [polypeptide binding]; other site 226185008186 active site 226185008187 metal binding site [ion binding]; metal-binding site 226185008188 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 226185008189 dsRNA binding site [nucleotide binding]; other site 226185008190 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 226185008191 Transposase, Mutator family; Region: Transposase_mut; pfam00872 226185008192 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 226185008193 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 226185008194 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 226185008195 Walker A/P-loop; other site 226185008196 ATP binding site [chemical binding]; other site 226185008197 Q-loop/lid; other site 226185008198 ABC transporter signature motif; other site 226185008199 Walker B; other site 226185008200 D-loop; other site 226185008201 H-loop/switch region; other site 226185008202 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 226185008203 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 226185008204 peptide binding site [polypeptide binding]; other site 226185008205 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171 226185008206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226185008207 dimer interface [polypeptide binding]; other site 226185008208 conserved gate region; other site 226185008209 putative PBP binding loops; other site 226185008210 ABC-ATPase subunit interface; other site 226185008211 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 226185008212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226185008213 dimer interface [polypeptide binding]; other site 226185008214 conserved gate region; other site 226185008215 putative PBP binding loops; other site 226185008216 ABC-ATPase subunit interface; other site 226185008217 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 226185008218 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 226185008219 Walker A/P-loop; other site 226185008220 ATP binding site [chemical binding]; other site 226185008221 Q-loop/lid; other site 226185008222 ABC transporter signature motif; other site 226185008223 Walker B; other site 226185008224 D-loop; other site 226185008225 H-loop/switch region; other site 226185008226 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 226185008227 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 226185008228 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 226185008229 Walker A/P-loop; other site 226185008230 ATP binding site [chemical binding]; other site 226185008231 Q-loop/lid; other site 226185008232 ABC transporter signature motif; other site 226185008233 Walker B; other site 226185008234 D-loop; other site 226185008235 H-loop/switch region; other site 226185008236 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 226185008237 acyl carrier protein; Provisional; Region: acpP; PRK00982 226185008238 putative phosphate acyltransferase; Provisional; Region: PRK05331 226185008239 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 226185008240 Y-family of DNA polymerases; Region: PolY; cl12025 226185008241 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 226185008242 generic binding surface II; other site 226185008243 ssDNA binding site; other site 226185008244 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226185008245 ATP binding site [chemical binding]; other site 226185008246 putative Mg++ binding site [ion binding]; other site 226185008247 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226185008248 nucleotide binding region [chemical binding]; other site 226185008249 ATP-binding site [chemical binding]; other site 226185008250 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 226185008251 DAK2 domain; Region: Dak2; pfam02734 226185008252 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 226185008253 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 226185008254 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 226185008255 Thiamine pyrophosphokinase; Region: TPK; cd07995 226185008256 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 226185008257 active site 226185008258 dimerization interface [polypeptide binding]; other site 226185008259 thiamine binding site [chemical binding]; other site 226185008260 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 226185008261 substrate binding site [chemical binding]; other site 226185008262 hexamer interface [polypeptide binding]; other site 226185008263 metal binding site [ion binding]; metal-binding site 226185008264 GTPase RsgA; Reviewed; Region: PRK00098 226185008265 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 226185008266 RNA binding site [nucleotide binding]; other site 226185008267 homodimer interface [polypeptide binding]; other site 226185008268 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 226185008269 GTPase/Zn-binding domain interface [polypeptide binding]; other site 226185008270 GTP/Mg2+ binding site [chemical binding]; other site 226185008271 G4 box; other site 226185008272 G5 box; other site 226185008273 G1 box; other site 226185008274 Switch I region; other site 226185008275 G2 box; other site 226185008276 G3 box; other site 226185008277 Switch II region; other site 226185008278 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 226185008279 Catalytic domain of Protein Kinases; Region: PKc; cd00180 226185008280 active site 226185008281 ATP binding site [chemical binding]; other site 226185008282 substrate binding site [chemical binding]; other site 226185008283 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 226185008284 substrate binding site [chemical binding]; other site 226185008285 activation loop (A-loop); other site 226185008286 activation loop (A-loop); other site 226185008287 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 226185008288 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 226185008289 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 226185008290 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 226185008291 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 226185008292 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 226185008293 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 226185008294 active site 226185008295 16S rRNA methyltransferase B; Provisional; Region: PRK14902 226185008296 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 226185008297 putative RNA binding site [nucleotide binding]; other site 226185008298 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226185008299 S-adenosylmethionine binding site [chemical binding]; other site 226185008300 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 226185008301 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 226185008302 putative active site [active] 226185008303 substrate binding site [chemical binding]; other site 226185008304 putative cosubstrate binding site; other site 226185008305 catalytic site [active] 226185008306 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 226185008307 substrate binding site [chemical binding]; other site 226185008308 primosome assembly protein PriA; Validated; Region: PRK05580 226185008309 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226185008310 ATP binding site [chemical binding]; other site 226185008311 putative Mg++ binding site [ion binding]; other site 226185008312 Predicted Zn-ribbon RNA-binding protein with a function in translation [Translation, ribosomal structure and biogenesis]; Region: COG2888; cl19729 226185008313 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226185008314 nucleotide binding region [chemical binding]; other site 226185008315 ATP-binding site [chemical binding]; other site 226185008316 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 226185008317 Guanylate kinase; Region: Guanylate_kin; pfam00625 226185008318 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 226185008319 catalytic site [active] 226185008320 G-X2-G-X-G-K; other site 226185008321 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 226185008322 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 226185008323 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 226185008324 Putative lysophospholipase; Region: Hydrolase_4; cl19140 226185008325 hypothetical protein; Provisional; Region: PRK11820 226185008326 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 226185008327 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 226185008328 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4443 226185008329 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 226185008330 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 226185008331 active site 226185008332 intersubunit interface [polypeptide binding]; other site 226185008333 catalytic residue [active] 226185008334 mannonate dehydratase; Provisional; Region: PRK03906 226185008335 D-mannonate dehydratase (UxuA); Region: UxuA; pfam03786 226185008336 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 226185008337 active pocket/dimerization site; other site 226185008338 active site 226185008339 phosphorylation site [posttranslational modification] 226185008340 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 226185008341 active site 226185008342 phosphorylation site [posttranslational modification] 226185008343 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 226185008344 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 226185008345 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 226185008346 putative active site [active] 226185008347 metal binding site [ion binding]; metal-binding site 226185008348 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 226185008349 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_12; cd12177 226185008350 putative ligand binding site [chemical binding]; other site 226185008351 putative NAD binding site [chemical binding]; other site 226185008352 catalytic site [active] 226185008353 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 226185008354 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 226185008355 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 226185008356 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 226185008357 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 226185008358 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 226185008359 putative active site [active] 226185008360 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 226185008361 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 226185008362 Helix-turn-helix domain; Region: HTH_25; pfam13413 226185008363 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 226185008364 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 226185008365 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 226185008366 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 226185008367 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 226185008368 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 226185008369 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 226185008370 WxL domain surface cell wall-binding; Region: WxL; pfam13731 226185008371 WxL domain surface cell wall-binding; Region: WxL; pfam13731 226185008372 WxL domain surface cell wall-binding; Region: WxL; pfam13731 226185008373 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 226185008374 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226185008375 DNA-binding site [nucleotide binding]; DNA binding site 226185008376 UTRA domain; Region: UTRA; pfam07702 226185008377 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 226185008378 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 226185008379 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 226185008380 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 226185008381 HAD-hyrolase-like; Region: Hydrolase_like; cl19142 226185008382 beta-phosphoglucomutase; Region: bPGM; TIGR01990 226185008383 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226185008384 motif II; other site 226185008385 leucyl-tRNA synthetase, eubacterial and mitochondrial family; Region: leuS_bact; TIGR00396 226185008386 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 226185008387 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 226185008388 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 226185008389 active site 226185008390 methionine sulfoxide reductase B; Provisional; Region: PRK00222 226185008391 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 226185008392 active site 226185008393 dimer interface [polypeptide binding]; other site 226185008394 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 226185008395 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226185008396 ATP binding site [chemical binding]; other site 226185008397 Mg2+ binding site [ion binding]; other site 226185008398 G-X-G motif; other site 226185008399 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 226185008400 ATP binding site [chemical binding]; other site 226185008401 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 226185008402 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 226185008403 MutS domain I; Region: MutS_I; pfam01624 226185008404 MutS domain II; Region: MutS_II; pfam05188 226185008405 MutS domain III; Region: MutS_III; pfam05192 226185008406 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 226185008407 Walker A/P-loop; other site 226185008408 ATP binding site [chemical binding]; other site 226185008409 Q-loop/lid; other site 226185008410 ABC transporter signature motif; other site 226185008411 Walker B; other site 226185008412 D-loop; other site 226185008413 H-loop/switch region; other site 226185008414 Protein of unknown function (DUF964); Region: DUF964; cl01483 226185008415 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 226185008416 putative active site [active] 226185008417 metal binding site [ion binding]; metal-binding site 226185008418 homodimer binding site [polypeptide binding]; other site 226185008419 ribonuclease Y; Region: RNase_Y; TIGR03319 226185008420 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 226185008421 KH domain; Region: KH_1; pfam00013 226185008422 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 226185008423 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 226185008424 Zn2+ binding site [ion binding]; other site 226185008425 Mg2+ binding site [ion binding]; other site 226185008426 recombinase A; Provisional; Region: recA; PRK09354 226185008427 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 226185008428 hexamer interface [polypeptide binding]; other site 226185008429 Walker A motif; other site 226185008430 ATP binding site [chemical binding]; other site 226185008431 Walker B motif; other site 226185008432 competence damage-inducible protein A; Provisional; Region: PRK00549 226185008433 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 226185008434 putative MPT binding site; other site 226185008435 Competence-damaged protein; Region: CinA; pfam02464 226185008436 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 226185008437 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 226185008438 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 226185008439 NAD binding site [chemical binding]; other site 226185008440 substrate binding site [chemical binding]; other site 226185008441 putative active site [active] 226185008442 Predicted transcriptional regulator [Transcription]; Region: COG1959 226185008443 Rrf2 family protein; Region: rrf2_super; TIGR00738 226185008444 hypothetical protein; Provisional; Region: PRK11770 226185008445 Domain of unknown function (DUF307); Region: DUF307; pfam03733 226185008446 Domain of unknown function (DUF307); Region: DUF307; pfam03733 226185008447 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 226185008448 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 226185008449 metal binding site [ion binding]; metal-binding site 226185008450 dimer interface [polypeptide binding]; other site 226185008451 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 226185008452 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 226185008453 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226185008454 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226185008455 DNA binding residues [nucleotide binding] 226185008456 Mga helix-turn-helix domain; Region: Mga; pfam05043 226185008457 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14960 226185008458 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 226185008459 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 226185008460 WxL domain surface cell wall-binding; Region: WxL; pfam13731 226185008461 WxL domain surface cell wall-binding; Region: WxL; pfam13731 226185008462 WxL domain surface cell wall-binding; Region: WxL; pfam13731 226185008463 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 226185008464 WxL domain surface cell wall-binding; Region: WxL; pfam13731 226185008465 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 226185008466 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 226185008467 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 226185008468 catalytic triad [active] 226185008469 conserved cis-peptide bond; other site 226185008470 antiholin-like protein LrgB; Provisional; Region: PRK04288 226185008471 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 226185008472 two-component response regulator; Provisional; Region: PRK14084 226185008473 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226185008474 active site 226185008475 phosphorylation site [posttranslational modification] 226185008476 intermolecular recognition site; other site 226185008477 dimerization interface [polypeptide binding]; other site 226185008478 LytTr DNA-binding domain; Region: LytTR; pfam04397 226185008479 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 226185008480 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 226185008481 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 226185008482 Histidine kinase; Region: His_kinase; pfam06580 226185008483 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226185008484 ATP binding site [chemical binding]; other site 226185008485 Mg2+ binding site [ion binding]; other site 226185008486 G-X-G motif; other site 226185008487 NLPA lipoprotein; Region: Lipoprotein_9; cl19159 226185008488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226185008489 dimer interface [polypeptide binding]; other site 226185008490 conserved gate region; other site 226185008491 putative PBP binding loops; other site 226185008492 ABC-ATPase subunit interface; other site 226185008493 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 226185008494 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 226185008495 Walker A/P-loop; other site 226185008496 ATP binding site [chemical binding]; other site 226185008497 Q-loop/lid; other site 226185008498 ABC transporter signature motif; other site 226185008499 Walker B; other site 226185008500 D-loop; other site 226185008501 H-loop/switch region; other site 226185008502 OsmC-like protein; Region: OsmC; pfam02566 226185008503 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 226185008504 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 226185008505 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 226185008506 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 226185008507 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 226185008508 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 226185008509 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 226185008510 metal binding site [ion binding]; metal-binding site 226185008511 YodA lipocalin-like domain; Region: YodA; pfam09223 226185008512 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 226185008513 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 226185008514 FMN binding site [chemical binding]; other site 226185008515 active site 226185008516 catalytic residues [active] 226185008517 substrate binding site [chemical binding]; other site 226185008518 inner membrane transport permease; Provisional; Region: PRK15066 226185008519 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 226185008520 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 226185008521 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 226185008522 Walker A/P-loop; other site 226185008523 ATP binding site [chemical binding]; other site 226185008524 Q-loop/lid; other site 226185008525 ABC transporter signature motif; other site 226185008526 Walker B; other site 226185008527 D-loop; other site 226185008528 H-loop/switch region; other site 226185008529 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 226185008530 active pocket/dimerization site; other site 226185008531 active site 226185008532 phosphorylation site [posttranslational modification] 226185008533 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 226185008534 active site 226185008535 phosphorylation site [posttranslational modification] 226185008536 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 226185008537 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 226185008538 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 226185008539 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226185008540 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 226185008541 Walker A motif; other site 226185008542 ATP binding site [chemical binding]; other site 226185008543 Walker B motif; other site 226185008544 arginine finger; other site 226185008545 Transposase, Mutator family; Region: Transposase_mut; pfam00872 226185008546 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 226185008547 Transcriptional antiterminator [Transcription]; Region: COG3933 226185008548 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 226185008549 active pocket/dimerization site; other site 226185008550 active site 226185008551 phosphorylation site [posttranslational modification] 226185008552 PRD domain; Region: PRD; pfam00874 226185008553 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 226185008554 PLD-like domain; Region: PLDc_2; pfam13091 226185008555 putative homodimer interface [polypeptide binding]; other site 226185008556 putative active site [active] 226185008557 catalytic site [active] 226185008558 DEAD-like helicases superfamily; Region: DEXDc; smart00487 226185008559 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226185008560 ATP binding site [chemical binding]; other site 226185008561 putative Mg++ binding site [ion binding]; other site 226185008562 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226185008563 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 226185008564 nucleotide binding region [chemical binding]; other site 226185008565 ATP-binding site [chemical binding]; other site 226185008566 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 226185008567 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 226185008568 active site 226185008569 8-oxo-dGMP binding site [chemical binding]; other site 226185008570 nudix motif; other site 226185008571 metal binding site [ion binding]; metal-binding site 226185008572 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226185008573 non-specific DNA binding site [nucleotide binding]; other site 226185008574 salt bridge; other site 226185008575 sequence-specific DNA binding site [nucleotide binding]; other site 226185008576 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 226185008577 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226185008578 sequence-specific DNA binding site [nucleotide binding]; other site 226185008579 salt bridge; other site 226185008580 V-type ATP synthase subunit I; Validated; Region: PRK05771 226185008581 putative replication initiation protein; Region: PHA00330 226185008582 Helix-turn-helix domain; Region: HTH_17; pfam12728 226185008583 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 226185008584 Ferritin-like domain; Region: Ferritin; pfam00210 226185008585 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 226185008586 dimerization interface [polypeptide binding]; other site 226185008587 DPS ferroxidase diiron center [ion binding]; other site 226185008588 ion pore; other site 226185008589 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 226185008590 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 226185008591 N- and C-terminal domain interface [polypeptide binding]; other site 226185008592 active site 226185008593 catalytic site [active] 226185008594 metal binding site [ion binding]; metal-binding site 226185008595 carbohydrate binding site [chemical binding]; other site 226185008596 ATP binding site [chemical binding]; other site 226185008597 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 226185008598 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 226185008599 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 226185008600 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 226185008601 beta and beta' interface [polypeptide binding]; other site 226185008602 beta' and sigma factor interface [polypeptide binding]; other site 226185008603 Zn-binding [ion binding]; other site 226185008604 active site region [active] 226185008605 catalytic site [active] 226185008606 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 226185008607 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 226185008608 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 226185008609 G-loop; other site 226185008610 DNA binding site [nucleotide binding] 226185008611 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 226185008612 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 226185008613 RPB12 interaction site [polypeptide binding]; other site 226185008614 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl19478 226185008615 RPB1 interaction site [polypeptide binding]; other site 226185008616 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 226185008617 RPB10 interaction site [polypeptide binding]; other site 226185008618 RPB11 interaction site [polypeptide binding]; other site 226185008619 RPB3 interaction site [polypeptide binding]; other site 226185008620 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855 226185008621 Biotin operon repressor [Transcription]; Region: BirA; COG1654 226185008622 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 226185008623 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 226185008624 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 226185008625 RloB-like protein; Region: RloB; pfam13707 226185008626 Predicted ATPases [General function prediction only]; Region: COG1106 226185008627 AAA domain; Region: AAA_21; pfam13304 226185008628 Q-loop/lid; other site 226185008629 ABC transporter signature motif; other site 226185008630 AAA domain; Region: AAA_21; pfam13304 226185008631 Walker B; other site 226185008632 H-loop/switch region; other site 226185008633 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 226185008634 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 226185008635 active site 226185008636 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 226185008637 WxL domain surface cell wall-binding; Region: WxL; pfam13731 226185008638 WxL domain surface cell wall-binding; Region: WxL; pfam13731 226185008639 WxL domain surface cell wall-binding; Region: WxL; pfam13731 226185008640 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 226185008641 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 226185008642 putative active site [active] 226185008643 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 226185008644 FMN-binding domain; Region: FMN_bind; cl01081 226185008645 FMN-binding domain; Region: FMN_bind; cl01081 226185008646 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 226185008647 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 226185008648 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 226185008649 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 226185008650 trimer interface [polypeptide binding]; other site 226185008651 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 226185008652 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 226185008653 substrate binding pocket [chemical binding]; other site 226185008654 chain length determination region; other site 226185008655 substrate-Mg2+ binding site; other site 226185008656 catalytic residues [active] 226185008657 aspartate-rich region 1; other site 226185008658 active site lid residues [active] 226185008659 aspartate-rich region 2; other site 226185008660 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 226185008661 PemK-like protein; Region: PemK; pfam02452 226185008662 similar to hypothetical protein; similar to GP:10172957; identified by sequence similarity 226185008663 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 226185008664 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 226185008665 substrate binding pocket [chemical binding]; other site 226185008666 dimer interface [polypeptide binding]; other site 226185008667 inhibitor binding site; inhibition site 226185008668 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 226185008669 active site 226185008670 dimerization interface [polypeptide binding]; other site 226185008671 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 226185008672 active site 226185008673 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 226185008674 catalytic center binding site [active] 226185008675 ATP binding site [chemical binding]; other site 226185008676 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 226185008677 homooctamer interface [polypeptide binding]; other site 226185008678 active site 226185008679 glutathione-disulfide reductase, animal/bacterial; Region: gluta_reduc_1; TIGR01421 226185008680 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 226185008681 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 226185008682 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 226185008683 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226185008684 non-specific DNA binding site [nucleotide binding]; other site 226185008685 salt bridge; other site 226185008686 sequence-specific DNA binding site [nucleotide binding]; other site 226185008687 Domain of unknown function (DUF955); Region: DUF955; cl01076 226185008688 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 226185008689 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 226185008690 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 226185008691 Uncharacterized conserved protein [Function unknown]; Region: COG3535 226185008692 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 226185008693 Na binding site [ion binding]; other site 226185008694 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 226185008695 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 226185008696 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 226185008697 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 226185008698 putative protease; Provisional; Region: PRK15452 226185008699 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 226185008700 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 226185008701 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 226185008702 Clp amino terminal domain; Region: Clp_N; pfam02861 226185008703 Clp amino terminal domain; Region: Clp_N; pfam02861 226185008704 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226185008705 Walker A motif; other site 226185008706 ATP binding site [chemical binding]; other site 226185008707 Walker B motif; other site 226185008708 arginine finger; other site 226185008709 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226185008710 Walker A motif; other site 226185008711 ATP binding site [chemical binding]; other site 226185008712 Walker B motif; other site 226185008713 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 226185008714 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 226185008715 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 226185008716 homodimer interface [polypeptide binding]; other site 226185008717 substrate-cofactor binding pocket; other site 226185008718 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226185008719 catalytic residue [active] 226185008720 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 226185008721 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 226185008722 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 226185008723 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 226185008724 putative active site [active] 226185008725 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226185008726 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226185008727 active site 226185008728 phosphorylation site [posttranslational modification] 226185008729 intermolecular recognition site; other site 226185008730 dimerization interface [polypeptide binding]; other site 226185008731 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226185008732 DNA binding site [nucleotide binding] 226185008733 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226185008734 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226185008735 dimer interface [polypeptide binding]; other site 226185008736 phosphorylation site [posttranslational modification] 226185008737 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226185008738 ATP binding site [chemical binding]; other site 226185008739 Mg2+ binding site [ion binding]; other site 226185008740 G-X-G motif; other site 226185008741 seryl-tRNA synthetase; Provisional; Region: PRK05431 226185008742 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 226185008743 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 226185008744 dimer interface [polypeptide binding]; other site 226185008745 active site 226185008746 motif 1; other site 226185008747 motif 2; other site 226185008748 motif 3; other site 226185008749 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 226185008750 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 226185008751 active site 226185008752 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 226185008753 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 226185008754 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 226185008755 GTP-binding protein YchF; Reviewed; Region: PRK09601 226185008756 YchF GTPase; Region: YchF; cd01900 226185008757 G1 box; other site 226185008758 GTP/Mg2+ binding site [chemical binding]; other site 226185008759 Switch I region; other site 226185008760 G2 box; other site 226185008761 Switch II region; other site 226185008762 G3 box; other site 226185008763 G4 box; other site 226185008764 G5 box; other site 226185008765 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 226185008766 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 226185008767 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 226185008768 ParB-like nuclease domain; Region: ParBc; pfam02195 226185008769 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226185008770 salt bridge; other site 226185008771 non-specific DNA binding site [nucleotide binding]; other site 226185008772 sequence-specific DNA binding site [nucleotide binding]; other site 226185008773 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 226185008774 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 226185008775 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 226185008776 P-loop; other site 226185008777 Magnesium ion binding site [ion binding]; other site 226185008778 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 226185008779 Methyltransferase domain; Region: Methyltransf_31; pfam13847 226185008780 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226185008781 S-adenosylmethionine binding site [chemical binding]; other site 226185008782 Protein of unknown function (DUF3114); Region: DUF3114; pfam11311 226185008783 Myosin-crossreactive antigen [Function unknown]; Region: COG4716 226185008784 myosin-cross-reactive antigen; Provisional; Region: PRK13977 226185008785 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 226185008786 active site 226185008787 intersubunit interactions; other site 226185008788 catalytic residue [active] 226185008789 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 226185008790 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 226185008791 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 226185008792 Nucleoside recognition; Region: Gate; pfam07670 226185008793 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 226185008794 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 226185008795 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 226185008796 HTH domain; Region: HTH_11; cl17392 226185008797 HTH domain; Region: HTH_11; pfam08279 226185008798 PRD domain; Region: PRD; pfam00874 226185008799 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 226185008800 active site 226185008801 P-loop; other site 226185008802 phosphorylation site [posttranslational modification] 226185008803 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 226185008804 active site 226185008805 phosphorylation site [posttranslational modification] 226185008806 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 226185008807 classical (c) SDRs; Region: SDR_c; cd05233 226185008808 NAD(P) binding site [chemical binding]; other site 226185008809 active site 226185008810 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 226185008811 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 226185008812 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 226185008813 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 226185008814 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 226185008815 trmE is a tRNA modification GTPase; Region: trmE; cd04164 226185008816 G1 box; other site 226185008817 GTP/Mg2+ binding site [chemical binding]; other site 226185008818 Switch I region; other site 226185008819 G2 box; other site 226185008820 Switch II region; other site 226185008821 G3 box; other site 226185008822 G4 box; other site 226185008823 G5 box; other site 226185008824 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 226185008825 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 226185008826 flagellin; Validated; Region: PRK08026 226185008827 triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125 226185008828 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 226185008829 Malic enzyme, N-terminal domain; Region: malic; pfam00390 226185008830 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 226185008831 NAD(P) binding pocket [chemical binding]; other site 226185008832 oxaloacetate decarboxylase; Provisional; Region: PRK12331 226185008833 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 226185008834 active site 226185008835 catalytic residues [active] 226185008836 metal binding site [ion binding]; metal-binding site 226185008837 homodimer binding site [polypeptide binding]; other site 226185008838 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 226185008839 2'-(5''-triphosphoribosyl)-3'- dephospho-CoA:apo-citrate lyase; Reviewed; Region: citX; PRK01392 226185008840 Citrate lyase, alpha subunit (CitF); Region: CitF; pfam04223 226185008841 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 226185008842 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 226185008843 citrate lyase subunit gamma; Provisional; Region: PRK13253 226185008844 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 226185008845 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 226185008846 putative active site [active] 226185008847 (T/H)XGH motif; other site 226185008848 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 226185008849 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 226185008850 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 226185008851 carboxyltransferase (CT) interaction site; other site 226185008852 biotinylation site [posttranslational modification]; other site 226185008853 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 226185008854 Citrate transporter; Region: CitMHS; pfam03600 226185008855 Transcriptional regulators [Transcription]; Region: FadR; COG2186 226185008856 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226185008857 DNA-binding site [nucleotide binding]; DNA binding site 226185008858 FCD domain; Region: FCD; pfam07729 226185008859 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226185008860 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226185008861 active site 226185008862 phosphorylation site [posttranslational modification] 226185008863 intermolecular recognition site; other site 226185008864 dimerization interface [polypeptide binding]; other site 226185008865 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226185008866 DNA binding site [nucleotide binding] 226185008867 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 226185008868 Jag N-terminus; Region: Jag_N; pfam14804 226185008869 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 226185008870 G-X-X-G motif; other site 226185008871 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 226185008872 RxxxH motif; other site 226185008873 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 226185008874 ribonuclease P; Reviewed; Region: rnpA; PRK00499 226185008875 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 226185008876 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 226185008877 TraB family; Region: TraB; cl12050 226185008878 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 226185008879 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 226185008880 peptide binding site [polypeptide binding]; other site 226185008881 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 226185008882 Integrase core domain; Region: rve; pfam00665 226185008883 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226185008884 S-adenosylmethionine binding site [chemical binding]; other site 226185008885 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 226185008886 Integrase core domain; Region: rve; pfam00665 226185008887 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 226185008888 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 226185008889 Replication protein; Region: Rep_1; cl02412 226185008890 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 226185008891 Integrase core domain; Region: rve; pfam00665 226185008892 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 226185008893 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 226185008894 DDE domain; Region: DDE_Tnp_IS240; pfam13610 226185008895 Integrase core domain; Region: rve; pfam00665 226185008896 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 226185008897 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 226185008898 dimer interface [polypeptide binding]; other site 226185008899 ssDNA binding site [nucleotide binding]; other site 226185008900 tetramer (dimer of dimers) interface [polypeptide binding]; other site 226185008901 PcfK-like protein; Region: PcfK; pfam14058 226185008902 Replication-relaxation; Region: Replic_Relax; pfam13814 226185008903 Domain of unknown function DUF87; Region: DUF87; cl19135 226185008904 AAA-like domain; Region: AAA_10; pfam12846 226185008905 Cdc37 N terminal kinase binding; Region: CDC37_N; cl03951 226185008906 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 226185008907 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 226185008908 AAA-like domain; Region: AAA_10; pfam12846 226185008909 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 226185008910 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 226185008911 dimer interface [polypeptide binding]; other site 226185008912 ssDNA binding site [nucleotide binding]; other site 226185008913 tetramer (dimer of dimers) interface [polypeptide binding]; other site 226185008914 TcpE family; Region: TcpE; pfam12648 226185008915 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 226185008916 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 226185008917 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 226185008918 CHAP domain; Region: CHAP; pfam05257 226185008919 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 226185008920 hypothetical protein; Provisional; Region: PRK05849 226185008921 PrgU-like protein; Region: PrgU; pfam09627 226185008922 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 226185008923 putative protease; Region: PHA00666 226185008924 Glucan-binding protein C; Region: GbpC; pfam08363 226185008925 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 226185008926 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 226185008927 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 226185008928 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 226185008929 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 226185008930 SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133 226185008931 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 226185008932 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 226185008933 Integrase core domain; Region: rve; pfam00665 226185008934 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 226185008935 Transcriptional regulator; Region: Rrf2; cl17282 226185008936 Transposase, Mutator family; Region: Transposase_mut; pfam00872 226185008937 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 226185008938 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 226185008939 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226185008940 Coenzyme A binding pocket [chemical binding]; other site 226185008941 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 226185008942 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 226185008943 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 226185008944 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 226185008945 Phosphotransferase enzyme family; Region: APH; pfam01636 226185008946 active site 226185008947 substrate binding site [chemical binding]; other site 226185008948 ATP binding site [chemical binding]; other site 226185008949 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 226185008950 substrate binding site [chemical binding]; other site 226185008951 Transposase, Mutator family; Region: Transposase_mut; pfam00872 226185008952 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 226185008953 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 226185008954 Integrase core domain; Region: rve; pfam00665 226185008955 hypothetical protein; Region: PHA01748 226185008956 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 226185008957 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 226185008958 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 226185008959 active site turn [active] 226185008960 phosphorylation site [posttranslational modification] 226185008961 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 226185008962 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 226185008963 HPr interaction site; other site 226185008964 glycerol kinase (GK) interaction site [polypeptide binding]; other site 226185008965 active site 226185008966 phosphorylation site [posttranslational modification] 226185008967 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 226185008968 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 226185008969 substrate binding [chemical binding]; other site 226185008970 active site 226185008971 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 226185008972 Transcriptional regulators [Transcription]; Region: PurR; COG1609 226185008973 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 226185008974 DNA binding site [nucleotide binding] 226185008975 domain linker motif; other site 226185008976 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 226185008977 dimerization interface [polypeptide binding]; other site 226185008978 ligand binding site [chemical binding]; other site 226185008979 sodium binding site [ion binding]; other site 226185008980 PemK-like protein; Region: PemK; pfam02452 226185008981 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 226185008982 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 226185008983 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 226185008984 catalytic residues [active] 226185008985 catalytic nucleophile [active] 226185008986 Presynaptic Site I dimer interface [polypeptide binding]; other site 226185008987 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 226185008988 Synaptic Flat tetramer interface [polypeptide binding]; other site 226185008989 Synaptic Site I dimer interface [polypeptide binding]; other site 226185008990 DNA binding site [nucleotide binding] 226185008991 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 226185008992 DNA polymerase IV; Reviewed; Region: PRK03103 226185008993 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 226185008994 active site 226185008995 DNA binding site [nucleotide binding] 226185008996 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 226185008997 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 226185008998 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 226185008999 P-loop; other site 226185009000 Magnesium ion binding site [ion binding]; other site 226185009001 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 226185009002 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 226185009003 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 226185009004 Integrase core domain; Region: rve; pfam00665 226185009005 Transposase, Mutator family; Region: Transposase_mut; pfam00872 226185009006 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 226185009007 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 226185009008 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 226185009009 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 226185009010 active site 226185009011 DNA binding site [nucleotide binding] 226185009012 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 226185009013 Integrase core domain; Region: rve; pfam00665 226185009014 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 226185009015 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 226185009016 catalytic residues [active] 226185009017 catalytic nucleophile [active] 226185009018 Presynaptic Site I dimer interface [polypeptide binding]; other site 226185009019 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 226185009020 Synaptic Flat tetramer interface [polypeptide binding]; other site 226185009021 Synaptic Site I dimer interface [polypeptide binding]; other site 226185009022 DNA binding site [nucleotide binding] 226185009023 DNA polymerase IV; Reviewed; Region: PRK03103 226185009024 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 226185009025 active site 226185009026 DNA binding site [nucleotide binding] 226185009027 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 226185009028 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 226185009029 P-loop; other site 226185009030 Magnesium ion binding site [ion binding]; other site 226185009031 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 226185009032 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 226185009033 Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916 226185009034 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 226185009035 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 226185009036 peptide binding site [polypeptide binding]; other site 226185009037 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 226185009038 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 226185009039 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 226185009040 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 226185009041 cell division protein FtsN; Region: ftsN; TIGR02223 226185009042 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 226185009043 putative protease; Region: PHA00666 226185009044 Glucan-binding protein C; Region: GbpC; pfam08363 226185009045 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 226185009046 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 226185009047 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 226185009048 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 226185009049 Surface protein; Region: DUF3664; pfam12406 226185009050 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 226185009051 PrgI family protein; Region: PrgI; pfam12666 226185009052 AAA-like domain; Region: AAA_10; pfam12846 226185009053 rRNA processing; Region: rRNA_processing; pfam08524 226185009054 CHAP domain; Region: CHAP; pfam05257 226185009055 AAA domain; Region: AAA_13; pfam13166 226185009056 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 226185009057 Protein of unknown function (DUF3801); Region: DUF3801; pfam12687 226185009058 AAA-like domain; Region: AAA_10; pfam12846 226185009059 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 226185009060 Walker A motif; other site 226185009061 ATP binding site [chemical binding]; other site 226185009062 Walker B motif; other site 226185009063 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 226185009064 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 226185009065 Toprim-like; Region: Toprim_2; pfam13155 226185009066 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 226185009067 Domain of unknown function (DUF955); Region: DUF955; cl01076 226185009068 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03815 226185009069 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl19391 226185009070 PcfJ-like protein; Region: PcfJ; pfam14284 226185009071 PcfK-like protein; Region: PcfK; pfam14058 226185009072 DpnD/PcfM-like protein; Region: DpnD-PcfM; pfam14207 226185009073 glutamyl-tRNA reductase; Region: PLN00203 226185009074 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 226185009075 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 226185009076 dimer interface [polypeptide binding]; other site 226185009077 ssDNA binding site [nucleotide binding]; other site 226185009078 tetramer (dimer of dimers) interface [polypeptide binding]; other site 226185009079 Staphylococcal nuclease homologues; Region: SNc; smart00318 226185009080 Staphylococcal nuclease homologue; Region: SNase; pfam00565 226185009081 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 226185009082 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226185009083 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226185009084 non-specific DNA binding site [nucleotide binding]; other site 226185009085 salt bridge; other site 226185009086 sequence-specific DNA binding site [nucleotide binding]; other site 226185009087 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 226185009088 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 226185009089 putative metal binding site; other site 226185009090 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 226185009091 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 226185009092 putative active site [active] 226185009093 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 226185009094 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226185009095 Walker A/P-loop; other site 226185009096 ATP binding site [chemical binding]; other site 226185009097 Q-loop/lid; other site 226185009098 ABC transporter signature motif; other site 226185009099 Walker B; other site 226185009100 D-loop; other site 226185009101 H-loop/switch region; other site 226185009102 Transposase, Mutator family; Region: Transposase_mut; pfam00872 226185009103 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 226185009104 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 226185009105 ABC transporter signature motif; other site 226185009106 Walker B; other site 226185009107 D-loop; other site 226185009108 H-loop/switch region; other site 226185009109 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 226185009110 catalytic residues [active] 226185009111 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 226185009112 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 226185009113 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 226185009114 catalytic residues [active] 226185009115 catalytic nucleophile [active] 226185009116 Presynaptic Site I dimer interface [polypeptide binding]; other site 226185009117 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 226185009118 Synaptic Flat tetramer interface [polypeptide binding]; other site 226185009119 Synaptic Site I dimer interface [polypeptide binding]; other site 226185009120 DNA binding site [nucleotide binding] 226185009121 Protein of unknown function DUF262; Region: DUF262; pfam03235 226185009122 DNA polymerase IV; Reviewed; Region: PRK03103 226185009123 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 226185009124 active site 226185009125 DNA binding site [nucleotide binding] 226185009126 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 226185009127 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 226185009128 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 226185009129 P-loop; other site 226185009130 Magnesium ion binding site [ion binding]; other site