-- dump date 20140619_073919 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1206105000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1206105000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1206105000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206105000004 Walker A motif; other site 1206105000005 ATP binding site [chemical binding]; other site 1206105000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1206105000007 Walker B motif; other site 1206105000008 arginine finger; other site 1206105000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1206105000010 DnaA box-binding interface [nucleotide binding]; other site 1206105000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 1206105000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1206105000013 putative DNA binding surface [nucleotide binding]; other site 1206105000014 dimer interface [polypeptide binding]; other site 1206105000015 beta-clamp/clamp loader binding surface; other site 1206105000016 beta-clamp/translesion DNA polymerase binding surface; other site 1206105000017 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 1206105000018 recombination protein F; Reviewed; Region: recF; PRK00064 1206105000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1206105000020 Walker A/P-loop; other site 1206105000021 ATP binding site [chemical binding]; other site 1206105000022 Q-loop/lid; other site 1206105000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206105000024 ABC transporter signature motif; other site 1206105000025 Walker B; other site 1206105000026 D-loop; other site 1206105000027 H-loop/switch region; other site 1206105000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1206105000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1206105000030 Mg2+ binding site [ion binding]; other site 1206105000031 G-X-G motif; other site 1206105000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1206105000033 anchoring element; other site 1206105000034 dimer interface [polypeptide binding]; other site 1206105000035 ATP binding site [chemical binding]; other site 1206105000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1206105000037 active site 1206105000038 putative metal-binding site [ion binding]; other site 1206105000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1206105000040 DNA gyrase subunit A; Validated; Region: PRK05560 1206105000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1206105000042 CAP-like domain; other site 1206105000043 active site 1206105000044 primary dimer interface [polypeptide binding]; other site 1206105000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1206105000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1206105000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1206105000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1206105000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1206105000050 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1206105000051 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1206105000052 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1206105000053 dimer interface [polypeptide binding]; other site 1206105000054 ssDNA binding site [nucleotide binding]; other site 1206105000055 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1206105000056 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1206105000057 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1206105000058 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1206105000059 DHH family; Region: DHH; pfam01368 1206105000060 DHHA1 domain; Region: DHHA1; pfam02272 1206105000061 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1206105000062 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1206105000063 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1206105000064 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1206105000065 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1206105000066 active site turn [active] 1206105000067 phosphorylation site [posttranslational modification] 1206105000068 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1206105000069 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1206105000070 HPr interaction site; other site 1206105000071 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1206105000072 active site 1206105000073 phosphorylation site [posttranslational modification] 1206105000074 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1206105000075 beta-galactosidase; Region: BGL; TIGR03356 1206105000076 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1206105000077 CAT RNA binding domain; Region: CAT_RBD; smart01061 1206105000078 PRD domain; Region: PRD; pfam00874 1206105000079 PRD domain; Region: PRD; pfam00874 1206105000080 replicative DNA helicase; Provisional; Region: PRK05748 1206105000081 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1206105000082 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1206105000083 Walker A motif; other site 1206105000084 ATP binding site [chemical binding]; other site 1206105000085 Walker B motif; other site 1206105000086 DNA binding loops [nucleotide binding] 1206105000087 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1206105000088 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1206105000089 GDP-binding site [chemical binding]; other site 1206105000090 ACT binding site; other site 1206105000091 IMP binding site; other site 1206105000092 EDD domain protein, DegV family; Region: DegV; TIGR00762 1206105000093 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1206105000094 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1206105000095 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206105000096 Walker A/P-loop; other site 1206105000097 ATP binding site [chemical binding]; other site 1206105000098 Q-loop/lid; other site 1206105000099 ABC transporter signature motif; other site 1206105000100 Walker B; other site 1206105000101 D-loop; other site 1206105000102 H-loop/switch region; other site 1206105000103 ABC transporter; Region: ABC_tran_2; pfam12848 1206105000104 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1206105000105 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 1206105000106 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1206105000107 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206105000108 Walker A motif; other site 1206105000109 ATP binding site [chemical binding]; other site 1206105000110 Walker B motif; other site 1206105000111 arginine finger; other site 1206105000112 Transcriptional antiterminator [Transcription]; Region: COG3933 1206105000113 PRD domain; Region: PRD; pfam00874 1206105000114 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1206105000115 active pocket/dimerization site; other site 1206105000116 active site 1206105000117 phosphorylation site [posttranslational modification] 1206105000118 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cd00133 1206105000119 active site 1206105000120 P-loop; other site 1206105000121 phosphorylation site [posttranslational modification] 1206105000122 PRD domain; Region: PRD; pfam00874 1206105000123 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1206105000124 active site 1206105000125 phosphorylation site [posttranslational modification] 1206105000126 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1206105000127 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1206105000128 active pocket/dimerization site; other site 1206105000129 active site 1206105000130 phosphorylation site [posttranslational modification] 1206105000131 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1206105000132 active site 1206105000133 phosphorylation site [posttranslational modification] 1206105000134 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1206105000135 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1206105000136 Domain of unknown function (DUF956); Region: DUF956; pfam06115 1206105000137 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1206105000138 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1206105000139 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1206105000140 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1206105000141 putative active site [active] 1206105000142 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1206105000143 PTS system, maltose and glucose-specific IIBC component; Region: PTS-IIBC-malX; TIGR02004 1206105000144 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1206105000145 active site turn [active] 1206105000146 phosphorylation site [posttranslational modification] 1206105000147 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1206105000148 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1206105000149 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206105000150 homodimer interface [polypeptide binding]; other site 1206105000151 catalytic residue [active] 1206105000152 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1206105000153 homotrimer interaction site [polypeptide binding]; other site 1206105000154 putative active site [active] 1206105000155 Predicted integral membrane protein [Function unknown]; Region: COG0392 1206105000156 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1206105000157 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1206105000158 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1206105000159 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 1206105000160 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1206105000161 dimer interface [polypeptide binding]; other site 1206105000162 Predicted transcriptional regulator [Transcription]; Region: COG2378 1206105000163 HTH domain; Region: HTH_11; pfam08279 1206105000164 WYL domain; Region: WYL; pfam13280 1206105000165 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1206105000166 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1206105000167 putative catalytic cysteine [active] 1206105000168 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 1206105000169 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1206105000170 nucleotide binding site [chemical binding]; other site 1206105000171 homotetrameric interface [polypeptide binding]; other site 1206105000172 putative phosphate binding site [ion binding]; other site 1206105000173 putative allosteric binding site; other site 1206105000174 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1206105000175 trimer interface [polypeptide binding]; other site 1206105000176 active site 1206105000177 DNA repair protein RadA; Provisional; Region: PRK11823 1206105000178 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1206105000179 Walker A motif/ATP binding site; other site 1206105000180 ATP binding site [chemical binding]; other site 1206105000181 Walker B motif; other site 1206105000182 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1206105000183 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1206105000184 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1206105000185 putative active site [active] 1206105000186 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1206105000187 homotrimer interaction site [polypeptide binding]; other site 1206105000188 zinc binding site [ion binding]; other site 1206105000189 CDP-binding sites; other site 1206105000190 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1206105000191 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1206105000192 HIGH motif; other site 1206105000193 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1206105000194 active site 1206105000195 KMSKS motif; other site 1206105000196 serine O-acetyltransferase; Region: cysE; TIGR01172 1206105000197 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1206105000198 trimer interface [polypeptide binding]; other site 1206105000199 active site 1206105000200 substrate binding site [chemical binding]; other site 1206105000201 CoA binding site [chemical binding]; other site 1206105000202 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1206105000203 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1206105000204 active site 1206105000205 HIGH motif; other site 1206105000206 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1206105000207 KMSKS motif; other site 1206105000208 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1206105000209 tRNA binding surface [nucleotide binding]; other site 1206105000210 anticodon binding site; other site 1206105000211 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1206105000212 active site 1206105000213 metal binding site [ion binding]; metal-binding site 1206105000214 dimerization interface [polypeptide binding]; other site 1206105000215 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1206105000216 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1206105000217 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1206105000218 YacP-like NYN domain; Region: NYN_YacP; pfam05991 1206105000219 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1206105000220 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1206105000221 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1206105000222 DNA binding residues [nucleotide binding] 1206105000223 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1206105000224 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1206105000225 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1206105000226 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1206105000227 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1206105000228 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1206105000229 metal binding site [ion binding]; metal-binding site 1206105000230 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1206105000231 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1206105000232 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1206105000233 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1206105000234 ABC-ATPase subunit interface; other site 1206105000235 dimer interface [polypeptide binding]; other site 1206105000236 putative PBP binding regions; other site 1206105000237 pur operon repressor; Provisional; Region: PRK09213 1206105000238 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1206105000239 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1206105000240 active site 1206105000241 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1206105000242 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1206105000243 Substrate binding site; other site 1206105000244 Mg++ binding site; other site 1206105000245 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1206105000246 active site 1206105000247 substrate binding site [chemical binding]; other site 1206105000248 CoA binding site [chemical binding]; other site 1206105000249 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1206105000250 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1206105000251 active site 1206105000252 metal binding site [ion binding]; metal-binding site 1206105000253 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1206105000254 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1206105000255 Helix-turn-helix domain; Region: HTH_38; pfam13936 1206105000256 Integrase core domain; Region: rve; pfam00665 1206105000257 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1206105000258 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1206105000259 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 1206105000260 putative active site [active] 1206105000261 putative metal binding site [ion binding]; other site 1206105000262 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1206105000263 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1206105000264 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1206105000265 peptide binding site [polypeptide binding]; other site 1206105000266 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 1206105000267 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1206105000268 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1206105000269 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1206105000270 Abi-like protein; Region: Abi_2; pfam07751 1206105000271 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1206105000272 RuvA N terminal domain; Region: RuvA_N; pfam01330 1206105000273 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1206105000274 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206105000275 Walker A motif; other site 1206105000276 ATP binding site [chemical binding]; other site 1206105000277 Walker B motif; other site 1206105000278 arginine finger; other site 1206105000279 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1206105000280 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 1206105000281 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1206105000282 putative active site cavity [active] 1206105000283 alpha-glucosidase; Provisional; Region: PRK10137 1206105000284 Protein of unknown function, DUF608; Region: DUF608; pfam04685 1206105000285 Trehalase; Region: Trehalase; cl17346 1206105000286 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1206105000287 non-specific DNA binding site [nucleotide binding]; other site 1206105000288 salt bridge; other site 1206105000289 sequence-specific DNA binding site [nucleotide binding]; other site 1206105000290 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1206105000291 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 1206105000292 ligand binding site [chemical binding]; other site 1206105000293 flexible hinge region; other site 1206105000294 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1206105000295 oxidoreductase; Provisional; Region: PRK07985 1206105000296 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1206105000297 NAD(P) binding site [chemical binding]; other site 1206105000298 active site 1206105000299 Small integral membrane protein (DUF2273); Region: DUF2273; cl11575 1206105000300 Asp23 family; Region: Asp23; pfam03780 1206105000301 Asp23 family; Region: Asp23; pfam03780 1206105000302 Predicted membrane protein [Function unknown]; Region: COG2261 1206105000303 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206105000304 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1206105000305 putative substrate translocation pore; other site 1206105000306 Mga helix-turn-helix domain; Region: Mga; pfam05043 1206105000307 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1206105000308 Collagen binding domain; Region: Collagen_bind; pfam05737 1206105000309 Collagen binding domain; Region: Collagen_bind; pfam05737 1206105000310 Collagen binding domain; Region: Collagen_bind; pfam05737 1206105000311 Collagen binding domain; Region: Collagen_bind; pfam05737 1206105000312 Collagen binding domain; Region: Collagen_bind; pfam05737 1206105000313 Cna protein B-type domain; Region: Cna_B; pfam05738 1206105000314 Cna protein B-type domain; Region: Cna_B; pfam05738 1206105000315 Cna protein B-type domain; Region: Cna_B; pfam05738 1206105000316 Cna protein B-type domain; Region: Cna_B; pfam05738 1206105000317 Cna protein B-type domain; Region: Cna_B; pfam05738 1206105000318 Cna protein B-type domain; Region: Cna_B; pfam05738 1206105000319 Cna protein B-type domain; Region: Cna_B; pfam05738 1206105000320 Cna protein B-type domain; Region: Cna_B; pfam05738 1206105000321 Cna protein B-type domain; Region: Cna_B; pfam05738 1206105000322 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1206105000323 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1206105000324 Mga helix-turn-helix domain; Region: Mga; pfam05043 1206105000325 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1206105000326 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1206105000327 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1206105000328 YheO-like PAS domain; Region: PAS_6; pfam08348 1206105000329 HTH domain; Region: HTH_22; pfam13309 1206105000330 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 1206105000331 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1206105000332 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 1206105000333 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1206105000334 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1206105000335 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1206105000336 seryl-tRNA synthetase; Provisional; Region: PRK05431 1206105000337 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1206105000338 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1206105000339 dimer interface [polypeptide binding]; other site 1206105000340 active site 1206105000341 motif 1; other site 1206105000342 motif 2; other site 1206105000343 motif 3; other site 1206105000344 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1206105000345 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1206105000346 Arginine repressor [Transcription]; Region: ArgR; COG1438 1206105000347 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1206105000348 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1206105000349 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1206105000350 Arginine repressor [Transcription]; Region: ArgR; COG1438 1206105000351 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1206105000352 arginine deiminase; Provisional; Region: PRK01388 1206105000353 ornithine carbamoyltransferase; Validated; Region: PRK02102 1206105000354 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1206105000355 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1206105000356 carbamate kinase; Reviewed; Region: PRK12686 1206105000357 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1206105000358 putative substrate binding site [chemical binding]; other site 1206105000359 nucleotide binding site [chemical binding]; other site 1206105000360 nucleotide binding site [chemical binding]; other site 1206105000361 homodimer interface [polypeptide binding]; other site 1206105000362 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1206105000363 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1206105000364 ligand binding site [chemical binding]; other site 1206105000365 flexible hinge region; other site 1206105000366 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1206105000367 putative switch regulator; other site 1206105000368 non-specific DNA interactions [nucleotide binding]; other site 1206105000369 DNA binding site [nucleotide binding] 1206105000370 sequence specific DNA binding site [nucleotide binding]; other site 1206105000371 putative cAMP binding site [chemical binding]; other site 1206105000372 Predicted membrane protein [Function unknown]; Region: COG1288 1206105000373 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1206105000374 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1206105000375 potential catalytic triad [active] 1206105000376 conserved cys residue [active] 1206105000377 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1206105000378 dimerization interface [polypeptide binding]; other site 1206105000379 putative DNA binding site [nucleotide binding]; other site 1206105000380 putative Zn2+ binding site [ion binding]; other site 1206105000381 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1206105000382 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1206105000383 putative NAD(P) binding site [chemical binding]; other site 1206105000384 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 1206105000385 active site 1206105000386 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 1206105000387 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 1206105000388 active site 1206105000389 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1206105000390 homotrimer interaction site [polypeptide binding]; other site 1206105000391 putative active site [active] 1206105000392 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1206105000393 homotrimer interaction site [polypeptide binding]; other site 1206105000394 putative active site [active] 1206105000395 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1206105000396 homotrimer interaction site [polypeptide binding]; other site 1206105000397 putative active site [active] 1206105000398 MepB protein; Region: MepB; pfam08877 1206105000399 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1206105000400 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1206105000401 DNA-binding site [nucleotide binding]; DNA binding site 1206105000402 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1206105000403 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206105000404 homodimer interface [polypeptide binding]; other site 1206105000405 catalytic residue [active] 1206105000406 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1206105000407 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1206105000408 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1206105000409 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 1206105000410 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 1206105000411 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1206105000412 Clostridial hydrophobic W; Region: ChW; pfam07538 1206105000413 Clostridial hydrophobic W; Region: ChW; pfam07538 1206105000414 Clostridial hydrophobic W; Region: ChW; pfam07538 1206105000415 Clostridial hydrophobic W; Region: ChW; pfam07538 1206105000416 Clostridial hydrophobic W; Region: ChW; cl02763 1206105000417 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1206105000418 Clostridial hydrophobic W; Region: ChW; pfam07538 1206105000419 Clostridial hydrophobic W; Region: ChW; pfam07538 1206105000420 Clostridial hydrophobic W; Region: ChW; cl02763 1206105000421 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1206105000422 putative active site [active] 1206105000423 GMP synthase; Reviewed; Region: guaA; PRK00074 1206105000424 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1206105000425 AMP/PPi binding site [chemical binding]; other site 1206105000426 candidate oxyanion hole; other site 1206105000427 catalytic triad [active] 1206105000428 potential glutamine specificity residues [chemical binding]; other site 1206105000429 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1206105000430 ATP Binding subdomain [chemical binding]; other site 1206105000431 Dimerization subdomain; other site 1206105000432 pantothenate kinase; Provisional; Region: PRK05439 1206105000433 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1206105000434 ATP-binding site [chemical binding]; other site 1206105000435 CoA-binding site [chemical binding]; other site 1206105000436 Mg2+-binding site [ion binding]; other site 1206105000437 Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838 1206105000438 catalytic triad [active] 1206105000439 oxyanion hole [active] 1206105000440 active site 1206105000441 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1206105000442 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206105000443 S-adenosylmethionine binding site [chemical binding]; other site 1206105000444 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1206105000445 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1206105000446 active site 1206105000447 purine riboside binding site [chemical binding]; other site 1206105000448 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1206105000449 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1206105000450 DNA binding site [nucleotide binding] 1206105000451 domain linker motif; other site 1206105000452 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1206105000453 dimerization interface [polypeptide binding]; other site 1206105000454 ligand binding site [chemical binding]; other site 1206105000455 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1206105000456 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1206105000457 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1206105000458 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1206105000459 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1206105000460 intersubunit interface [polypeptide binding]; other site 1206105000461 active site 1206105000462 catalytic residue [active] 1206105000463 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1206105000464 active site 1206105000465 catalytic motif [active] 1206105000466 Zn binding site [ion binding]; other site 1206105000467 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1206105000468 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1206105000469 ligand binding site [chemical binding]; other site 1206105000470 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1206105000471 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1206105000472 ligand binding site [chemical binding]; other site 1206105000473 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1206105000474 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206105000475 Walker A/P-loop; other site 1206105000476 ATP binding site [chemical binding]; other site 1206105000477 Q-loop/lid; other site 1206105000478 ABC transporter signature motif; other site 1206105000479 Walker B; other site 1206105000480 D-loop; other site 1206105000481 H-loop/switch region; other site 1206105000482 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1206105000483 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1206105000484 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1206105000485 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1206105000486 TM-ABC transporter signature motif; other site 1206105000487 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1206105000488 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1206105000489 TM-ABC transporter signature motif; other site 1206105000490 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 1206105000491 phosphopentomutase; Provisional; Region: PRK05362 1206105000492 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1206105000493 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1206105000494 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1206105000495 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1206105000496 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1206105000497 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1206105000498 putative ligand binding residues [chemical binding]; other site 1206105000499 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1206105000500 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1206105000501 Walker A/P-loop; other site 1206105000502 ATP binding site [chemical binding]; other site 1206105000503 Q-loop/lid; other site 1206105000504 ABC transporter signature motif; other site 1206105000505 Walker B; other site 1206105000506 D-loop; other site 1206105000507 H-loop/switch region; other site 1206105000508 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1206105000509 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1206105000510 ABC-ATPase subunit interface; other site 1206105000511 dimer interface [polypeptide binding]; other site 1206105000512 putative PBP binding regions; other site 1206105000513 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1206105000514 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1206105000515 ABC-ATPase subunit interface; other site 1206105000516 dimer interface [polypeptide binding]; other site 1206105000517 putative PBP binding regions; other site 1206105000518 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1206105000519 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1206105000520 dimer interface [polypeptide binding]; other site 1206105000521 active site 1206105000522 metal binding site [ion binding]; metal-binding site 1206105000523 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1206105000524 catalytic core [active] 1206105000525 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1206105000526 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1206105000527 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1206105000528 catalytic residues [active] 1206105000529 catalytic nucleophile [active] 1206105000530 Presynaptic Site I dimer interface [polypeptide binding]; other site 1206105000531 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1206105000532 Synaptic Flat tetramer interface [polypeptide binding]; other site 1206105000533 Synaptic Site I dimer interface [polypeptide binding]; other site 1206105000534 DNA binding site [nucleotide binding] 1206105000535 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1206105000536 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1206105000537 active site 1206105000538 dimer interface [polypeptide binding]; other site 1206105000539 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1206105000540 S17 interaction site [polypeptide binding]; other site 1206105000541 S8 interaction site; other site 1206105000542 16S rRNA interaction site [nucleotide binding]; other site 1206105000543 streptomycin interaction site [chemical binding]; other site 1206105000544 23S rRNA interaction site [nucleotide binding]; other site 1206105000545 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1206105000546 30S ribosomal protein S7; Validated; Region: PRK05302 1206105000547 elongation factor G; Reviewed; Region: PRK00007 1206105000548 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1206105000549 G1 box; other site 1206105000550 putative GEF interaction site [polypeptide binding]; other site 1206105000551 GTP/Mg2+ binding site [chemical binding]; other site 1206105000552 Switch I region; other site 1206105000553 G2 box; other site 1206105000554 G3 box; other site 1206105000555 Switch II region; other site 1206105000556 G4 box; other site 1206105000557 G5 box; other site 1206105000558 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1206105000559 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1206105000560 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1206105000561 elongation factor Tu; Reviewed; Region: PRK00049 1206105000562 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1206105000563 G1 box; other site 1206105000564 GEF interaction site [polypeptide binding]; other site 1206105000565 GTP/Mg2+ binding site [chemical binding]; other site 1206105000566 Switch I region; other site 1206105000567 G2 box; other site 1206105000568 G3 box; other site 1206105000569 Switch II region; other site 1206105000570 G4 box; other site 1206105000571 G5 box; other site 1206105000572 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1206105000573 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1206105000574 Antibiotic Binding Site [chemical binding]; other site 1206105000575 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1206105000576 dimer interface [polypeptide binding]; other site 1206105000577 substrate binding site [chemical binding]; other site 1206105000578 ATP binding site [chemical binding]; other site 1206105000579 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1206105000580 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206105000581 S-adenosylmethionine binding site [chemical binding]; other site 1206105000582 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1206105000583 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1206105000584 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1206105000585 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1206105000586 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1206105000587 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1206105000588 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1206105000589 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1206105000590 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1206105000591 putative translocon binding site; other site 1206105000592 protein-rRNA interface [nucleotide binding]; other site 1206105000593 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1206105000594 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1206105000595 G-X-X-G motif; other site 1206105000596 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1206105000597 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1206105000598 23S rRNA interface [nucleotide binding]; other site 1206105000599 5S rRNA interface [nucleotide binding]; other site 1206105000600 putative antibiotic binding site [chemical binding]; other site 1206105000601 L25 interface [polypeptide binding]; other site 1206105000602 L27 interface [polypeptide binding]; other site 1206105000603 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1206105000604 23S rRNA interface [nucleotide binding]; other site 1206105000605 putative translocon interaction site; other site 1206105000606 signal recognition particle (SRP54) interaction site; other site 1206105000607 L23 interface [polypeptide binding]; other site 1206105000608 trigger factor interaction site; other site 1206105000609 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1206105000610 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1206105000611 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1206105000612 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1206105000613 RNA binding site [nucleotide binding]; other site 1206105000614 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1206105000615 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1206105000616 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1206105000617 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1206105000618 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1206105000619 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1206105000620 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1206105000621 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1206105000622 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1206105000623 5S rRNA interface [nucleotide binding]; other site 1206105000624 L27 interface [polypeptide binding]; other site 1206105000625 23S rRNA interface [nucleotide binding]; other site 1206105000626 L5 interface [polypeptide binding]; other site 1206105000627 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1206105000628 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1206105000629 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1206105000630 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1206105000631 23S rRNA binding site [nucleotide binding]; other site 1206105000632 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1206105000633 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1206105000634 SecY translocase; Region: SecY; pfam00344 1206105000635 adenylate kinase; Reviewed; Region: adk; PRK00279 1206105000636 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1206105000637 AMP-binding site [chemical binding]; other site 1206105000638 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1206105000639 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1206105000640 rRNA binding site [nucleotide binding]; other site 1206105000641 predicted 30S ribosome binding site; other site 1206105000642 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1206105000643 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1206105000644 30S ribosomal protein S11; Validated; Region: PRK05309 1206105000645 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1206105000646 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1206105000647 alphaNTD homodimer interface [polypeptide binding]; other site 1206105000648 alphaNTD - beta interaction site [polypeptide binding]; other site 1206105000649 alphaNTD - beta' interaction site [polypeptide binding]; other site 1206105000650 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1206105000651 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1206105000652 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1206105000653 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 1206105000654 metal binding site [ion binding]; metal-binding site 1206105000655 putative dimer interface [polypeptide binding]; other site 1206105000656 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 1206105000657 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1206105000658 Walker A/P-loop; other site 1206105000659 ATP binding site [chemical binding]; other site 1206105000660 Q-loop/lid; other site 1206105000661 ABC transporter signature motif; other site 1206105000662 Walker B; other site 1206105000663 D-loop; other site 1206105000664 H-loop/switch region; other site 1206105000665 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 1206105000666 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1206105000667 Walker A/P-loop; other site 1206105000668 ATP binding site [chemical binding]; other site 1206105000669 Q-loop/lid; other site 1206105000670 ABC transporter signature motif; other site 1206105000671 Walker B; other site 1206105000672 D-loop; other site 1206105000673 H-loop/switch region; other site 1206105000674 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1206105000675 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1206105000676 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1206105000677 dimerization interface 3.5A [polypeptide binding]; other site 1206105000678 active site 1206105000679 hypothetical protein; Provisional; Region: PRK00967 1206105000680 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1206105000681 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1206105000682 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1206105000683 Coenzyme A binding pocket [chemical binding]; other site 1206105000684 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1206105000685 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1206105000686 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1206105000687 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1206105000688 Walker A/P-loop; other site 1206105000689 ATP binding site [chemical binding]; other site 1206105000690 Q-loop/lid; other site 1206105000691 ABC transporter signature motif; other site 1206105000692 Walker B; other site 1206105000693 D-loop; other site 1206105000694 H-loop/switch region; other site 1206105000695 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1206105000696 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1206105000697 substrate binding pocket [chemical binding]; other site 1206105000698 membrane-bound complex binding site; other site 1206105000699 hinge residues; other site 1206105000700 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1206105000701 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206105000702 dimer interface [polypeptide binding]; other site 1206105000703 conserved gate region; other site 1206105000704 putative PBP binding loops; other site 1206105000705 ABC-ATPase subunit interface; other site 1206105000706 NAD-dependent deacetylase; Provisional; Region: PRK00481 1206105000707 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 1206105000708 NAD+ binding site [chemical binding]; other site 1206105000709 substrate binding site [chemical binding]; other site 1206105000710 putative Zn binding site [ion binding]; other site 1206105000711 maltose O-acetyltransferase; Provisional; Region: PRK10092 1206105000712 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1206105000713 active site 1206105000714 substrate binding site [chemical binding]; other site 1206105000715 trimer interface [polypeptide binding]; other site 1206105000716 CoA binding site [chemical binding]; other site 1206105000717 monofunctional chorismate mutase, gram positive-type, clade 2; Region: CM_mono_grmpos; TIGR01805 1206105000718 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 1206105000719 HTH domain; Region: HTH_11; pfam08279 1206105000720 3H domain; Region: 3H; pfam02829 1206105000721 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1206105000722 CHAP domain; Region: CHAP; pfam05257 1206105000723 Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117 1206105000724 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1206105000725 NAD(P) binding site [chemical binding]; other site 1206105000726 catalytic residues [active] 1206105000727 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1206105000728 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1206105000729 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1206105000730 NAD binding site [chemical binding]; other site 1206105000731 dimer interface [polypeptide binding]; other site 1206105000732 substrate binding site [chemical binding]; other site 1206105000733 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1206105000734 putative active site [active] 1206105000735 catalytic residue [active] 1206105000736 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1206105000737 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1206105000738 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1206105000739 ATP binding site [chemical binding]; other site 1206105000740 putative Mg++ binding site [ion binding]; other site 1206105000741 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1206105000742 nucleotide binding region [chemical binding]; other site 1206105000743 ATP-binding site [chemical binding]; other site 1206105000744 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1206105000745 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1206105000746 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1206105000747 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1206105000748 RNA binding surface [nucleotide binding]; other site 1206105000749 hypothetical protein; Provisional; Region: PRK08582 1206105000750 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1206105000751 RNA binding site [nucleotide binding]; other site 1206105000752 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1206105000753 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1206105000754 Ligand Binding Site [chemical binding]; other site 1206105000755 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1206105000756 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1206105000757 active site 1206105000758 FtsH Extracellular; Region: FtsH_ext; pfam06480 1206105000759 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1206105000760 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206105000761 Walker A motif; other site 1206105000762 ATP binding site [chemical binding]; other site 1206105000763 Walker B motif; other site 1206105000764 arginine finger; other site 1206105000765 Peptidase family M41; Region: Peptidase_M41; pfam01434 1206105000766 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1206105000767 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1206105000768 dimerization interface [polypeptide binding]; other site 1206105000769 domain crossover interface; other site 1206105000770 redox-dependent activation switch; other site 1206105000771 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1206105000772 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1206105000773 FMN binding site [chemical binding]; other site 1206105000774 active site 1206105000775 catalytic residues [active] 1206105000776 substrate binding site [chemical binding]; other site 1206105000777 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1206105000778 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1206105000779 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1206105000780 dimer interface [polypeptide binding]; other site 1206105000781 putative anticodon binding site; other site 1206105000782 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1206105000783 motif 1; other site 1206105000784 active site 1206105000785 motif 2; other site 1206105000786 motif 3; other site 1206105000787 CAT RNA binding domain; Region: CAT_RBD; pfam03123 1206105000788 PRD domain; Region: PRD; pfam00874 1206105000789 PRD domain; Region: PRD; pfam00874 1206105000790 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1206105000791 HPr interaction site; other site 1206105000792 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1206105000793 active site 1206105000794 phosphorylation site [posttranslational modification] 1206105000795 6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593 1206105000796 beta-galactosidase; Region: BGL; TIGR03356 1206105000797 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1206105000798 beta-galactosidase; Region: BGL; TIGR03356 1206105000799 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1206105000800 catalytic core [active] 1206105000801 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1206105000802 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1206105000803 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1206105000804 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1206105000805 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1206105000806 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1206105000807 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1206105000808 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1206105000809 DNA binding site [nucleotide binding] 1206105000810 active site 1206105000811 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1206105000812 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1206105000813 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1206105000814 Zn2+ binding site [ion binding]; other site 1206105000815 Mg2+ binding site [ion binding]; other site 1206105000816 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1206105000817 Cation efflux family; Region: Cation_efflux; pfam01545 1206105000818 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06079 1206105000819 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1206105000820 NAD binding site [chemical binding]; other site 1206105000821 homotetramer interface [polypeptide binding]; other site 1206105000822 homodimer interface [polypeptide binding]; other site 1206105000823 substrate binding site [chemical binding]; other site 1206105000824 active site 1206105000825 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1206105000826 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1206105000827 dimer interface [polypeptide binding]; other site 1206105000828 active site 1206105000829 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1206105000830 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1206105000831 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 1206105000832 active site 1206105000833 FMN binding site [chemical binding]; other site 1206105000834 substrate binding site [chemical binding]; other site 1206105000835 catalytic residues [active] 1206105000836 homodimer interface [polypeptide binding]; other site 1206105000837 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 1206105000838 elongation factor P; Validated; Region: PRK00529 1206105000839 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1206105000840 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1206105000841 RNA binding site [nucleotide binding]; other site 1206105000842 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1206105000843 RNA binding site [nucleotide binding]; other site 1206105000844 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1206105000845 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1206105000846 dimer interface [polypeptide binding]; other site 1206105000847 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206105000848 catalytic residue [active] 1206105000849 cystathionine gamma-synthase/cystathionine beta-lyase; Validated; Region: PRK06176 1206105000850 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1206105000851 homodimer interface [polypeptide binding]; other site 1206105000852 substrate-cofactor binding pocket; other site 1206105000853 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206105000854 catalytic residue [active] 1206105000855 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 1206105000856 beta-galactosidase; Region: BGL; TIGR03356 1206105000857 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1206105000858 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1206105000859 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1206105000860 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1206105000861 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1206105000862 putative active site [active] 1206105000863 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1206105000864 RibD C-terminal domain; Region: RibD_C; cl17279 1206105000865 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1206105000866 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1206105000867 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1206105000868 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1206105000869 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 1206105000870 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1206105000871 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1206105000872 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1206105000873 metal-binding site [ion binding] 1206105000874 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1206105000875 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1206105000876 metal-binding site [ion binding] 1206105000877 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1206105000878 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1206105000879 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1206105000880 metal-binding site [ion binding] 1206105000881 Predicted membrane protein [General function prediction only]; Region: COG4194 1206105000882 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1206105000883 DNA-binding site [nucleotide binding]; DNA binding site 1206105000884 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1206105000885 trimer interface [polypeptide binding]; other site 1206105000886 active site 1206105000887 G bulge; other site 1206105000888 similar to phiFL4A phage 1206105000889 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1206105000890 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 1206105000891 Int/Topo IB signature motif; other site 1206105000892 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1206105000893 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1206105000894 non-specific DNA binding site [nucleotide binding]; other site 1206105000895 salt bridge; other site 1206105000896 sequence-specific DNA binding site [nucleotide binding]; other site 1206105000897 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1206105000898 non-specific DNA binding site [nucleotide binding]; other site 1206105000899 salt bridge; other site 1206105000900 sequence-specific DNA binding site [nucleotide binding]; other site 1206105000901 Protein of unknown function (DUF1140); Region: DUF1140; pfam06600 1206105000902 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 1206105000903 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 1206105000904 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 1206105000905 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 1206105000906 active site 1206105000907 DNA binding site [nucleotide binding] 1206105000908 catalytic site [active] 1206105000909 Virulence-associated protein E; Region: VirE; pfam05272 1206105000910 VRR-NUC domain; Region: VRR_NUC; pfam08774 1206105000911 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1206105000912 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1206105000913 ATP binding site [chemical binding]; other site 1206105000914 putative Mg++ binding site [ion binding]; other site 1206105000915 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1206105000916 nucleotide binding region [chemical binding]; other site 1206105000917 ATP-binding site [chemical binding]; other site 1206105000918 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1206105000919 DNA binding residues [nucleotide binding] 1206105000920 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 1206105000921 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 1206105000922 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1206105000923 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 1206105000924 active site 1206105000925 conformational flexibility of ligand binding pocket; other site 1206105000926 ADP-ribosylating toxin turn-turn motif; other site 1206105000927 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 1206105000928 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 1206105000929 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 1206105000930 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 1206105000931 Phage-related protein [Function unknown]; Region: COG5412 1206105000932 Phage-related protein [Function unknown]; Region: COG5412 1206105000933 Phage tail protein; Region: Sipho_tail; pfam05709 1206105000934 Haemolysin XhlA; Region: XhlA; pfam10779 1206105000935 Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415 1206105000936 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1206105000937 active site 1206105000938 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 1206105000939 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1206105000940 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1206105000941 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1206105000942 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1206105000943 Zn binding site [ion binding]; other site 1206105000944 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1206105000945 Zn binding site [ion binding]; other site 1206105000946 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1206105000947 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1206105000948 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 1206105000949 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 1206105000950 putative active site [active] 1206105000951 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1206105000952 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 1206105000953 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1206105000954 active site 1206105000955 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1206105000956 active site 1206105000957 Protein of unknown function DUF72; Region: DUF72; pfam01904 1206105000958 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545 1206105000959 putative nucleotide binding site [chemical binding]; other site 1206105000960 putative metal binding site [ion binding]; other site 1206105000961 aspartate kinase; Reviewed; Region: PRK09034 1206105000962 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1206105000963 putative catalytic residues [active] 1206105000964 putative nucleotide binding site [chemical binding]; other site 1206105000965 putative aspartate binding site [chemical binding]; other site 1206105000966 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1206105000967 allosteric regulatory residue; other site 1206105000968 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1206105000969 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1206105000970 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1206105000971 motif II; other site 1206105000972 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 1206105000973 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1206105000974 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1206105000975 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1206105000976 catalytic residue [active] 1206105000977 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1206105000978 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1206105000979 active site 1206105000980 phosphorylation site [posttranslational modification] 1206105000981 intermolecular recognition site; other site 1206105000982 dimerization interface [polypeptide binding]; other site 1206105000983 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1206105000984 DNA binding site [nucleotide binding] 1206105000985 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1206105000986 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1206105000987 dimer interface [polypeptide binding]; other site 1206105000988 phosphorylation site [posttranslational modification] 1206105000989 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1206105000990 ATP binding site [chemical binding]; other site 1206105000991 Mg2+ binding site [ion binding]; other site 1206105000992 G-X-G motif; other site 1206105000993 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1206105000994 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1206105000995 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1206105000996 putative deaminase; Validated; Region: PRK06846 1206105000997 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1206105000998 active site 1206105000999 Fic/DOC family; Region: Fic; cl00960 1206105001000 putative addiction module antidote; Region: doc_partner; TIGR02609 1206105001001 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1206105001002 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1206105001003 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1206105001004 membrane protein FdrA; Validated; Region: PRK06091 1206105001005 CoA binding domain; Region: CoA_binding; pfam02629 1206105001006 CoA-ligase; Region: Ligase_CoA; pfam00549 1206105001007 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 1206105001008 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 1206105001009 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206105001010 D-galactonate transporter; Region: 2A0114; TIGR00893 1206105001011 putative substrate translocation pore; other site 1206105001012 carbamate kinase; Reviewed; Region: PRK12686 1206105001013 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1206105001014 putative substrate binding site [chemical binding]; other site 1206105001015 nucleotide binding site [chemical binding]; other site 1206105001016 nucleotide binding site [chemical binding]; other site 1206105001017 homodimer interface [polypeptide binding]; other site 1206105001018 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1206105001019 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1206105001020 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1206105001021 cytosine deaminase; Provisional; Region: PRK05985 1206105001022 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1206105001023 active site 1206105001024 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1206105001025 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1206105001026 TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329 1206105001027 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1206105001028 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1206105001029 substrate binding site [chemical binding]; other site 1206105001030 THF binding site; other site 1206105001031 zinc-binding site [ion binding]; other site 1206105001032 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1206105001033 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1206105001034 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 1206105001035 Protein of unknown function (DUF969); Region: DUF969; pfam06149 1206105001036 Predicted membrane protein [Function unknown]; Region: COG3817 1206105001037 Protein of unknown function (DUF979); Region: DUF979; pfam06166 1206105001038 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1206105001039 putative substrate binding pocket [chemical binding]; other site 1206105001040 AC domain interface; other site 1206105001041 catalytic triad [active] 1206105001042 AB domain interface; other site 1206105001043 interchain disulfide; other site 1206105001044 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1206105001045 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1206105001046 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1206105001047 putative DNA binding site [nucleotide binding]; other site 1206105001048 putative Zn2+ binding site [ion binding]; other site 1206105001049 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1206105001050 dimer interface [polypeptide binding]; other site 1206105001051 FMN binding site [chemical binding]; other site 1206105001052 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1206105001053 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1206105001054 active site 1206105001055 motif I; other site 1206105001056 motif II; other site 1206105001057 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1206105001058 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1206105001059 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1206105001060 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1206105001061 active site 1206105001062 P-loop; other site 1206105001063 phosphorylation site [posttranslational modification] 1206105001064 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 1206105001065 active site 1206105001066 P-loop; other site 1206105001067 phosphorylation site [posttranslational modification] 1206105001068 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1206105001069 PRD domain; Region: PRD; pfam00874 1206105001070 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1206105001071 P-loop; other site 1206105001072 active site 1206105001073 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 1206105001074 active site 1206105001075 phosphorylation site [posttranslational modification] 1206105001076 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1206105001077 active site 1206105001078 phosphorylation site [posttranslational modification] 1206105001079 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1206105001080 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1206105001081 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1206105001082 active site 1206105001083 P-loop; other site 1206105001084 phosphorylation site [posttranslational modification] 1206105001085 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1206105001086 active site 1206105001087 P-loop; other site 1206105001088 phosphorylation site [posttranslational modification] 1206105001089 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1206105001090 active site 1206105001091 phosphorylation site [posttranslational modification] 1206105001092 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1206105001093 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1206105001094 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1206105001095 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1206105001096 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1206105001097 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1206105001098 NAD(P) binding site [chemical binding]; other site 1206105001099 active site 1206105001100 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 1206105001101 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1206105001102 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1206105001103 Walker A/P-loop; other site 1206105001104 ATP binding site [chemical binding]; other site 1206105001105 Q-loop/lid; other site 1206105001106 ABC transporter signature motif; other site 1206105001107 Walker B; other site 1206105001108 D-loop; other site 1206105001109 H-loop/switch region; other site 1206105001110 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1206105001111 FtsX-like permease family; Region: FtsX; pfam02687 1206105001112 TrbC/VIRB2 family; Region: TrbC; pfam04956 1206105001113 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1206105001114 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206105001115 putative substrate translocation pore; other site 1206105001116 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206105001117 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1206105001118 DNA binding residues [nucleotide binding] 1206105001119 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1206105001120 putative dimer interface [polypeptide binding]; other site 1206105001121 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1206105001122 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1206105001123 Bacterial transcriptional regulator; Region: IclR; pfam01614 1206105001124 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 1206105001125 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1206105001126 active site 1206105001127 intersubunit interface [polypeptide binding]; other site 1206105001128 catalytic residue [active] 1206105001129 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1206105001130 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1206105001131 substrate binding site [chemical binding]; other site 1206105001132 ATP binding site [chemical binding]; other site 1206105001133 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 1206105001134 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 1206105001135 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1206105001136 NADP binding site [chemical binding]; other site 1206105001137 homodimer interface [polypeptide binding]; other site 1206105001138 active site 1206105001139 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 1206105001140 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1206105001141 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1206105001142 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1206105001143 DctM-like transporters; Region: DctM; pfam06808 1206105001144 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1206105001145 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1206105001146 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1206105001147 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1206105001148 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1206105001149 N- and C-terminal domain interface [polypeptide binding]; other site 1206105001150 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 1206105001151 active site 1206105001152 putative catalytic site [active] 1206105001153 metal binding site [ion binding]; metal-binding site 1206105001154 ATP binding site [chemical binding]; other site 1206105001155 carbohydrate binding site [chemical binding]; other site 1206105001156 L-rhamnose isomerase; Provisional; Region: PRK01076 1206105001157 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 1206105001158 rhamnulose-1-phosphate aldolase; Region: rhamnu_1P_ald; TIGR02624 1206105001159 intersubunit interface [polypeptide binding]; other site 1206105001160 active site 1206105001161 Zn2+ binding site [ion binding]; other site 1206105001162 Domain of unknown function (DUF718); Region: DUF718; cl01281 1206105001163 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1206105001164 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1206105001165 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1206105001166 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1206105001167 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1206105001168 Metal-binding active site; metal-binding site 1206105001169 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 1206105001170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206105001171 putative substrate translocation pore; other site 1206105001172 POT family; Region: PTR2; pfam00854 1206105001173 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1206105001174 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1206105001175 CoenzymeA binding site [chemical binding]; other site 1206105001176 subunit interaction site [polypeptide binding]; other site 1206105001177 PHB binding site; other site 1206105001178 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1206105001179 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1206105001180 substrate binding site [chemical binding]; other site 1206105001181 oxyanion hole (OAH) forming residues; other site 1206105001182 trimer interface [polypeptide binding]; other site 1206105001183 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 1206105001184 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1206105001185 acyl-activating enzyme (AAE) consensus motif; other site 1206105001186 putative AMP binding site [chemical binding]; other site 1206105001187 putative active site [active] 1206105001188 putative CoA binding site [chemical binding]; other site 1206105001189 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1206105001190 isochorismate synthases; Region: isochor_syn; TIGR00543 1206105001191 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1206105001192 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1206105001193 dimer interface [polypeptide binding]; other site 1206105001194 tetramer interface [polypeptide binding]; other site 1206105001195 PYR/PP interface [polypeptide binding]; other site 1206105001196 TPP binding site [chemical binding]; other site 1206105001197 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1206105001198 TPP-binding site; other site 1206105001199 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1206105001200 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1206105001201 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 1206105001202 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1206105001203 active site 1206105001204 octamer interface [polypeptide binding]; other site 1206105001205 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1206105001206 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1206105001207 active site 1206105001208 trimer interface [polypeptide binding]; other site 1206105001209 allosteric site; other site 1206105001210 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1206105001211 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1206105001212 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1206105001213 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1206105001214 acyl-activating enzyme (AAE) consensus motif; other site 1206105001215 acyl-activating enzyme (AAE) consensus motif; other site 1206105001216 AMP binding site [chemical binding]; other site 1206105001217 active site 1206105001218 CoA binding site [chemical binding]; other site 1206105001219 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1206105001220 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1206105001221 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 1206105001222 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 1206105001223 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1206105001224 active site 1206105001225 phosphorylation site [posttranslational modification] 1206105001226 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 1206105001227 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1206105001228 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1206105001229 putative active site [active] 1206105001230 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: PRK12570 1206105001231 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1206105001232 putative active site [active] 1206105001233 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1206105001234 Beta-lactamase; Region: Beta-lactamase; pfam00144 1206105001235 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1206105001236 active pocket/dimerization site; other site 1206105001237 active site 1206105001238 phosphorylation site [posttranslational modification] 1206105001239 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 1206105001240 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1206105001241 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1206105001242 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1206105001243 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1206105001244 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1206105001245 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1206105001246 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1206105001247 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1206105001248 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1206105001249 active site 1206105001250 trimer interface [polypeptide binding]; other site 1206105001251 allosteric site; other site 1206105001252 active site lid [active] 1206105001253 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1206105001254 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1206105001255 MgtC family; Region: MgtC; pfam02308 1206105001256 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1206105001257 Repair protein; Region: Repair_PSII; pfam04536 1206105001258 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1206105001259 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1206105001260 dimer interface [polypeptide binding]; other site 1206105001261 putative radical transfer pathway; other site 1206105001262 diiron center [ion binding]; other site 1206105001263 tyrosyl radical; other site 1206105001264 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 1206105001265 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1206105001266 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1206105001267 active site 1206105001268 dimer interface [polypeptide binding]; other site 1206105001269 catalytic residues [active] 1206105001270 effector binding site; other site 1206105001271 R2 peptide binding site; other site 1206105001272 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1206105001273 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1206105001274 catalytic residues [active] 1206105001275 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 1206105001276 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1206105001277 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1206105001278 G1 box; other site 1206105001279 GTP/Mg2+ binding site [chemical binding]; other site 1206105001280 Switch I region; other site 1206105001281 G2 box; other site 1206105001282 G3 box; other site 1206105001283 Switch II region; other site 1206105001284 G4 box; other site 1206105001285 G5 box; other site 1206105001286 Nucleoside recognition; Region: Gate; pfam07670 1206105001287 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1206105001288 Nucleoside recognition; Region: Gate; pfam07670 1206105001289 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1206105001290 Int/Topo IB signature motif; other site 1206105001291 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1206105001292 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1206105001293 DNA binding residues [nucleotide binding] 1206105001294 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1206105001295 Integrase core domain; Region: rve; pfam00665 1206105001296 putative transposase OrfB; Reviewed; Region: PHA02517 1206105001297 HTH-like domain; Region: HTH_21; pfam13276 1206105001298 Integrase core domain; Region: rve; pfam00665 1206105001299 Integrase core domain; Region: rve_2; pfam13333 1206105001300 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1206105001301 Transposase; Region: HTH_Tnp_1; pfam01527 1206105001302 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 1206105001303 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1206105001304 P-loop; other site 1206105001305 Magnesium ion binding site [ion binding]; other site 1206105001306 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1206105001307 Magnesium ion binding site [ion binding]; other site 1206105001308 Omega Transcriptional Repressor; Region: Omega_Repress; pfam07764 1206105001309 Bacterial epsilon antitoxin; Region: Epsilon_antitox; pfam08998 1206105001310 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 1206105001311 GTP/Mg2+ binding site [chemical binding]; other site 1206105001312 G5 box; other site 1206105001313 G1 box; other site 1206105001314 Switch I region; other site 1206105001315 G2 box; other site 1206105001316 G3 box; other site 1206105001317 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1206105001318 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1206105001319 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1206105001320 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 1206105001321 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 1206105001322 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1206105001323 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 1206105001324 putative substrate binding site [chemical binding]; other site 1206105001325 putative ATP binding site [chemical binding]; other site 1206105001326 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 1206105001327 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1206105001328 methionine cluster; other site 1206105001329 active site 1206105001330 phosphorylation site [posttranslational modification] 1206105001331 metal binding site [ion binding]; metal-binding site 1206105001332 phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394 1206105001333 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1206105001334 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 1206105001335 active site 1206105001336 P-loop; other site 1206105001337 phosphorylation site [posttranslational modification] 1206105001338 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 1206105001339 beta-galactosidase; Region: BGL; TIGR03356 1206105001340 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 1206105001341 active site 1206105001342 catalytic residues [active] 1206105001343 Zeta toxin; Region: Zeta_toxin; pfam06414 1206105001344 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 1206105001345 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1206105001346 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1206105001347 catalytic residues [active] 1206105001348 catalytic nucleophile [active] 1206105001349 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1206105001350 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1206105001351 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1206105001352 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1206105001353 active site 1206105001354 Mga helix-turn-helix domain; Region: Mga; pfam05043 1206105001355 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1206105001356 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1206105001357 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1206105001358 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1206105001359 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 1206105001360 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1206105001361 Helix-turn-helix domain; Region: HTH_38; pfam13936 1206105001362 Integrase core domain; Region: rve; pfam00665 1206105001363 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1206105001364 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1206105001365 active site 1206105001366 catalytic tetrad [active] 1206105001367 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1206105001368 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1206105001369 active site 1206105001370 metal binding site [ion binding]; metal-binding site 1206105001371 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1206105001372 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1206105001373 putative active site [active] 1206105001374 catalytic site [active] 1206105001375 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1206105001376 putative active site [active] 1206105001377 catalytic site [active] 1206105001378 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 1206105001379 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1206105001380 active site 1206105001381 HIGH motif; other site 1206105001382 dimer interface [polypeptide binding]; other site 1206105001383 KMSKS motif; other site 1206105001384 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1206105001385 RNA binding surface [nucleotide binding]; other site 1206105001386 tyrosine decarboxylase, Enterococcus type; Region: tyr_de_CO2_Ent; TIGR03811 1206105001387 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1206105001388 catalytic residue [active] 1206105001389 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 1206105001390 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1206105001391 Protein of unknown function (DUF1307); Region: DUF1307; pfam06998 1206105001392 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1206105001393 tetramer interfaces [polypeptide binding]; other site 1206105001394 binuclear metal-binding site [ion binding]; other site 1206105001395 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1206105001396 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1206105001397 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1206105001398 NAD binding site [chemical binding]; other site 1206105001399 dimer interface [polypeptide binding]; other site 1206105001400 substrate binding site [chemical binding]; other site 1206105001401 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1206105001402 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1206105001403 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1206105001404 dimerization interface [polypeptide binding]; other site 1206105001405 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1206105001406 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 1206105001407 gating phenylalanine in ion channel; other site 1206105001408 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1206105001409 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1206105001410 NAD(P) binding site [chemical binding]; other site 1206105001411 active site 1206105001412 Predicted transcriptional regulators [Transcription]; Region: COG1733 1206105001413 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1206105001414 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1206105001415 dimer interface [polypeptide binding]; other site 1206105001416 FMN binding site [chemical binding]; other site 1206105001417 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1206105001418 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1206105001419 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1206105001420 Peptidase family M48; Region: Peptidase_M48; cl12018 1206105001421 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1206105001422 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1206105001423 DNA binding site [nucleotide binding] 1206105001424 domain linker motif; other site 1206105001425 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1206105001426 putative dimerization interface [polypeptide binding]; other site 1206105001427 putative ligand binding site [chemical binding]; other site 1206105001428 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1206105001429 dimer interface [polypeptide binding]; other site 1206105001430 FMN binding site [chemical binding]; other site 1206105001431 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1206105001432 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1206105001433 putative metal binding site [ion binding]; other site 1206105001434 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1206105001435 active site 1206105001436 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1206105001437 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1206105001438 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1206105001439 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1206105001440 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1206105001441 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1206105001442 active site 1206105001443 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1206105001444 active site 1206105001445 Fe-S cluster binding site [ion binding]; other site 1206105001446 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 1206105001447 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1206105001448 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 1206105001449 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 1206105001450 active site 1206105001451 Zn binding site [ion binding]; other site 1206105001452 Predicted integral membrane protein [Function unknown]; Region: COG5652 1206105001453 hypothetical protein; Validated; Region: PRK00110 1206105001454 C_GCAxxG_C_C family probable redox protein; Region: C_GCAxxG_C_C; TIGR01909 1206105001455 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1206105001456 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1206105001457 Zn binding site [ion binding]; other site 1206105001458 putative hydrolase; Provisional; Region: PRK11460 1206105001459 Predicted esterase [General function prediction only]; Region: COG0400 1206105001460 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1206105001461 active site 1206105001462 catalytic motif [active] 1206105001463 Zn binding site [ion binding]; other site 1206105001464 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 1206105001465 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1206105001466 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1206105001467 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1206105001468 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1206105001469 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1206105001470 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1206105001471 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1206105001472 RNA binding surface [nucleotide binding]; other site 1206105001473 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1206105001474 active site 1206105001475 uracil binding [chemical binding]; other site 1206105001476 dipeptidase PepV; Region: dipeptidase; TIGR01886 1206105001477 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1206105001478 active site 1206105001479 metal binding site [ion binding]; metal-binding site 1206105001480 DNA primase large subunit; Validated; Region: PRK03968 1206105001481 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1206105001482 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1206105001483 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 1206105001484 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 1206105001485 CRISPR/Cas system-associated protein Csn2; Region: Csn2; cd09758 1206105001486 CRISPR type II-A/NMEMI-associated protein Csn2; Region: cas_Csn2; TIGR01866 1206105001487 tetramer interface [polypeptide binding]; other site 1206105001488 putative DNA binding site [nucleotide binding]; other site 1206105001489 Ca binding site [ion binding]; other site 1206105001490 Ca binding site [ion binding]; other site 1206105001491 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1206105001492 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1206105001493 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1206105001494 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206105001495 Walker A/P-loop; other site 1206105001496 ATP binding site [chemical binding]; other site 1206105001497 Q-loop/lid; other site 1206105001498 ABC transporter signature motif; other site 1206105001499 Walker B; other site 1206105001500 D-loop; other site 1206105001501 H-loop/switch region; other site 1206105001502 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206105001503 ABC-ATPase subunit interface; other site 1206105001504 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1206105001505 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1206105001506 Arginine repressor [Transcription]; Region: ArgR; COG1438 1206105001507 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1206105001508 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1206105001509 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1206105001510 active site 1206105001511 substrate binding site [chemical binding]; other site 1206105001512 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1206105001513 metal binding site [ion binding]; metal-binding site 1206105001514 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1206105001515 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1206105001516 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1206105001517 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1206105001518 active site 1206105001519 Transglycosylase; Region: Transgly; pfam00912 1206105001520 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1206105001521 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1206105001522 hypothetical protein; Provisional; Region: PRK13676 1206105001523 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1206105001524 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1206105001525 active site 1206105001526 metal binding site [ion binding]; metal-binding site 1206105001527 DNA binding site [nucleotide binding] 1206105001528 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1206105001529 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1206105001530 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1206105001531 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1206105001532 generic binding surface II; other site 1206105001533 generic binding surface I; other site 1206105001534 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1206105001535 Zn2+ binding site [ion binding]; other site 1206105001536 Mg2+ binding site [ion binding]; other site 1206105001537 foldase protein PrsA; Reviewed; Region: prsA; PRK01326 1206105001538 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1206105001539 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1206105001540 HIT family signature motif; other site 1206105001541 catalytic residue [active] 1206105001542 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1206105001543 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1206105001544 Walker A/P-loop; other site 1206105001545 ATP binding site [chemical binding]; other site 1206105001546 Q-loop/lid; other site 1206105001547 ABC transporter signature motif; other site 1206105001548 Walker B; other site 1206105001549 D-loop; other site 1206105001550 H-loop/switch region; other site 1206105001551 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 1206105001552 Thiamine kinase and related kinases [Coenzyme transport and metabolism]; Region: ycfN; COG0510 1206105001553 Phosphotransferase enzyme family; Region: APH; pfam01636 1206105001554 active site 1206105001555 substrate binding site [chemical binding]; other site 1206105001556 ATP binding site [chemical binding]; other site 1206105001557 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206105001558 S-adenosylmethionine binding site [chemical binding]; other site 1206105001559 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1206105001560 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1206105001561 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1206105001562 putative active site [active] 1206105001563 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1206105001564 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1206105001565 putative substrate binding site [chemical binding]; other site 1206105001566 putative ATP binding site [chemical binding]; other site 1206105001567 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1206105001568 active site 1206105001569 P-loop; other site 1206105001570 phosphorylation site [posttranslational modification] 1206105001571 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1206105001572 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1206105001573 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1206105001574 active site 1206105001575 phosphorylation site [posttranslational modification] 1206105001576 Class I aldolases; Region: Aldolase_Class_I; cl17187 1206105001577 hypothetical protein; Provisional; Region: PRK13662 1206105001578 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 1206105001579 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1206105001580 Coenzyme A binding pocket [chemical binding]; other site 1206105001581 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1206105001582 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1206105001583 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1206105001584 Domain of unknown function DUF21; Region: DUF21; pfam01595 1206105001585 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1206105001586 Transporter associated domain; Region: CorC_HlyC; pfam03471 1206105001587 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1206105001588 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1206105001589 G1 box; other site 1206105001590 putative GEF interaction site [polypeptide binding]; other site 1206105001591 GTP/Mg2+ binding site [chemical binding]; other site 1206105001592 Switch I region; other site 1206105001593 G2 box; other site 1206105001594 G3 box; other site 1206105001595 Switch II region; other site 1206105001596 G4 box; other site 1206105001597 G5 box; other site 1206105001598 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1206105001599 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 1206105001600 Predicted membrane protein [Function unknown]; Region: COG2323 1206105001601 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 1206105001602 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206105001603 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1206105001604 Walker A motif; other site 1206105001605 ATP binding site [chemical binding]; other site 1206105001606 Walker B motif; other site 1206105001607 arginine finger; other site 1206105001608 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206105001609 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1206105001610 Walker A motif; other site 1206105001611 ATP binding site [chemical binding]; other site 1206105001612 Walker B motif; other site 1206105001613 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1206105001614 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1206105001615 dimerization domain swap beta strand [polypeptide binding]; other site 1206105001616 regulatory protein interface [polypeptide binding]; other site 1206105001617 active site 1206105001618 regulatory phosphorylation site [posttranslational modification]; other site 1206105001619 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1206105001620 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1206105001621 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1206105001622 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1206105001623 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1206105001624 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 1206105001625 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1206105001626 trigger factor; Provisional; Region: tig; PRK01490 1206105001627 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1206105001628 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1206105001629 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1206105001630 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1206105001631 active site 1206105001632 phosphorylation site [posttranslational modification] 1206105001633 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1206105001634 active site 1206105001635 P-loop; other site 1206105001636 phosphorylation site [posttranslational modification] 1206105001637 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1206105001638 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1206105001639 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1206105001640 putative substrate binding site [chemical binding]; other site 1206105001641 putative ATP binding site [chemical binding]; other site 1206105001642 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1206105001643 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1206105001644 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1206105001645 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1206105001646 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1206105001647 Cl- selectivity filter; other site 1206105001648 Cl- binding residues [ion binding]; other site 1206105001649 pore gating glutamate residue; other site 1206105001650 dimer interface [polypeptide binding]; other site 1206105001651 H+/Cl- coupling transport residue; other site 1206105001652 TrkA-C domain; Region: TrkA_C; pfam02080 1206105001653 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1206105001654 Part of AAA domain; Region: AAA_19; pfam13245 1206105001655 Family description; Region: UvrD_C_2; pfam13538 1206105001656 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1206105001657 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1206105001658 nucleotide binding pocket [chemical binding]; other site 1206105001659 K-X-D-G motif; other site 1206105001660 catalytic site [active] 1206105001661 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1206105001662 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1206105001663 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1206105001664 Dimer interface [polypeptide binding]; other site 1206105001665 BRCT sequence motif; other site 1206105001666 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1206105001667 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1206105001668 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1206105001669 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1206105001670 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1206105001671 GatB domain; Region: GatB_Yqey; smart00845 1206105001672 putative lipid kinase; Reviewed; Region: PRK13055 1206105001673 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1206105001674 TRAM domain; Region: TRAM; cl01282 1206105001675 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1206105001676 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206105001677 S-adenosylmethionine binding site [chemical binding]; other site 1206105001678 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1206105001679 catalytic residues [active] 1206105001680 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1206105001681 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1206105001682 DNA binding residues [nucleotide binding] 1206105001683 dimerization interface [polypeptide binding]; other site 1206105001684 putrescine carbamoyltransferase; Provisional; Region: PRK02255 1206105001685 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1206105001686 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1206105001687 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1206105001688 agmatine deiminase; Provisional; Region: PRK13551 1206105001689 agmatine deiminase; Region: agmatine_aguA; TIGR03380 1206105001690 carbamate kinase; Reviewed; Region: PRK12686 1206105001691 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1206105001692 putative substrate binding site [chemical binding]; other site 1206105001693 nucleotide binding site [chemical binding]; other site 1206105001694 nucleotide binding site [chemical binding]; other site 1206105001695 homodimer interface [polypeptide binding]; other site 1206105001696 amidase; Provisional; Region: PRK06707 1206105001697 Amidase; Region: Amidase; cl11426 1206105001698 nicotinamide mononucleotide transporter PnuC; Region: NMN_trans_PnuC; TIGR01528 1206105001699 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1206105001700 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1206105001701 Substrate-binding site [chemical binding]; other site 1206105001702 Substrate specificity [chemical binding]; other site 1206105001703 Protein of unknown function (DUF1149); Region: DUF1149; pfam06619 1206105001704 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1206105001705 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1206105001706 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1206105001707 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1206105001708 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1206105001709 Beta-lactamase; Region: Beta-lactamase; pfam00144 1206105001710 Predicted membrane protein [Function unknown]; Region: COG4420 1206105001711 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1206105001712 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1206105001713 active site residue [active] 1206105001714 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 1206105001715 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 1206105001716 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1206105001717 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1206105001718 legume lectins; Region: lectin_L-type; cd01951 1206105001719 homotetramer interaction site [polypeptide binding]; other site 1206105001720 homodimer interaction site [polypeptide binding]; other site 1206105001721 carbohydrate binding site [chemical binding]; other site 1206105001722 metal binding site [ion binding]; metal-binding site 1206105001723 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1206105001724 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1206105001725 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1206105001726 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 1206105001727 Mga helix-turn-helix domain; Region: Mga; pfam05043 1206105001728 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1206105001729 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1206105001730 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1206105001731 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1206105001732 MgtC family; Region: MgtC; pfam02308 1206105001733 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1206105001734 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1206105001735 Walker A/P-loop; other site 1206105001736 ATP binding site [chemical binding]; other site 1206105001737 Q-loop/lid; other site 1206105001738 ABC transporter signature motif; other site 1206105001739 Walker B; other site 1206105001740 D-loop; other site 1206105001741 H-loop/switch region; other site 1206105001742 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1206105001743 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1206105001744 substrate binding pocket [chemical binding]; other site 1206105001745 membrane-bound complex binding site; other site 1206105001746 hinge residues; other site 1206105001747 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1206105001748 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1206105001749 substrate binding pocket [chemical binding]; other site 1206105001750 membrane-bound complex binding site; other site 1206105001751 hinge residues; other site 1206105001752 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1206105001753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206105001754 dimer interface [polypeptide binding]; other site 1206105001755 conserved gate region; other site 1206105001756 putative PBP binding loops; other site 1206105001757 ABC-ATPase subunit interface; other site 1206105001758 excinuclease ABC subunit B; Provisional; Region: PRK05298 1206105001759 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1206105001760 ATP binding site [chemical binding]; other site 1206105001761 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1206105001762 nucleotide binding region [chemical binding]; other site 1206105001763 ATP-binding site [chemical binding]; other site 1206105001764 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1206105001765 UvrB/uvrC motif; Region: UVR; pfam02151 1206105001766 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1206105001767 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1206105001768 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1206105001769 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1206105001770 YusW-like protein; Region: YusW; pfam14039 1206105001771 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1206105001772 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1206105001773 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1206105001774 phosphate binding site [ion binding]; other site 1206105001775 putative substrate binding pocket [chemical binding]; other site 1206105001776 dimer interface [polypeptide binding]; other site 1206105001777 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1206105001778 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1206105001779 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1206105001780 Thioredoxin; Region: Thioredoxin_4; pfam13462 1206105001781 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1206105001782 Clp protease; Region: CLP_protease; pfam00574 1206105001783 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1206105001784 oligomer interface [polypeptide binding]; other site 1206105001785 active site residues [active] 1206105001786 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 1206105001787 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1206105001788 metal ion-dependent adhesion site (MIDAS); other site 1206105001789 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1206105001790 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1206105001791 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1206105001792 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1206105001793 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1206105001794 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1206105001795 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 1206105001796 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1206105001797 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 1206105001798 putative active site [active] 1206105001799 catalytic site [active] 1206105001800 putative metal binding site [ion binding]; other site 1206105001801 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1206105001802 nudix motif; other site 1206105001803 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1206105001804 DNA-binding site [nucleotide binding]; DNA binding site 1206105001805 RNA-binding motif; other site 1206105001806 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 1206105001807 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1206105001808 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1206105001809 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1206105001810 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1206105001811 catalytic triad [active] 1206105001812 catalytic triad [active] 1206105001813 oxyanion hole [active] 1206105001814 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1206105001815 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1206105001816 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1206105001817 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1206105001818 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206105001819 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1206105001820 putative substrate translocation pore; other site 1206105001821 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206105001822 Predicted esterase [General function prediction only]; Region: COG0627 1206105001823 S-formylglutathione hydrolase; Region: PLN02442 1206105001824 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1206105001825 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206105001826 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1206105001827 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1206105001828 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206105001829 Walker A/P-loop; other site 1206105001830 ATP binding site [chemical binding]; other site 1206105001831 Q-loop/lid; other site 1206105001832 ABC transporter signature motif; other site 1206105001833 Walker B; other site 1206105001834 D-loop; other site 1206105001835 H-loop/switch region; other site 1206105001836 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1206105001837 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1206105001838 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1206105001839 Walker A/P-loop; other site 1206105001840 ATP binding site [chemical binding]; other site 1206105001841 Q-loop/lid; other site 1206105001842 ABC transporter signature motif; other site 1206105001843 Walker B; other site 1206105001844 D-loop; other site 1206105001845 H-loop/switch region; other site 1206105001846 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206105001847 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206105001848 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1206105001849 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1206105001850 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1206105001851 Walker A/P-loop; other site 1206105001852 ATP binding site [chemical binding]; other site 1206105001853 Q-loop/lid; other site 1206105001854 ABC transporter signature motif; other site 1206105001855 Walker B; other site 1206105001856 D-loop; other site 1206105001857 H-loop/switch region; other site 1206105001858 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1206105001859 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 1206105001860 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1206105001861 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1206105001862 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1206105001863 active site 1206105001864 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1206105001865 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 1206105001866 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1206105001867 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1206105001868 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1206105001869 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1206105001870 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1206105001871 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1206105001872 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1206105001873 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1206105001874 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1206105001875 HIGH motif; other site 1206105001876 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1206105001877 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1206105001878 active site 1206105001879 KMSKS motif; other site 1206105001880 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1206105001881 tRNA binding surface [nucleotide binding]; other site 1206105001882 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 1206105001883 Fic/DOC family; Region: Fic; pfam02661 1206105001884 Fic family protein [Function unknown]; Region: COG3177 1206105001885 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1206105001886 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1206105001887 substrate binding pocket [chemical binding]; other site 1206105001888 membrane-bound complex binding site; other site 1206105001889 hinge residues; other site 1206105001890 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1206105001891 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206105001892 Walker A/P-loop; other site 1206105001893 ATP binding site [chemical binding]; other site 1206105001894 Q-loop/lid; other site 1206105001895 ABC transporter signature motif; other site 1206105001896 Walker B; other site 1206105001897 D-loop; other site 1206105001898 H-loop/switch region; other site 1206105001899 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1206105001900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206105001901 dimer interface [polypeptide binding]; other site 1206105001902 conserved gate region; other site 1206105001903 putative PBP binding loops; other site 1206105001904 ABC-ATPase subunit interface; other site 1206105001905 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1206105001906 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1206105001907 peptide binding site [polypeptide binding]; other site 1206105001908 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 1206105001909 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 1206105001910 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 1206105001911 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 1206105001912 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1206105001913 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1206105001914 DNA-binding site [nucleotide binding]; DNA binding site 1206105001915 UTRA domain; Region: UTRA; pfam07702 1206105001916 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1206105001917 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1206105001918 active pocket/dimerization site; other site 1206105001919 active site 1206105001920 phosphorylation site [posttranslational modification] 1206105001921 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1206105001922 active site 1206105001923 phosphorylation site [posttranslational modification] 1206105001924 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 1206105001925 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 1206105001926 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 1206105001927 substrate binding site [chemical binding]; other site 1206105001928 catalytic residues [active] 1206105001929 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 1206105001930 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1206105001931 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1206105001932 5S rRNA interface [nucleotide binding]; other site 1206105001933 CTC domain interface [polypeptide binding]; other site 1206105001934 L16 interface [polypeptide binding]; other site 1206105001935 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1206105001936 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1206105001937 RNA binding surface [nucleotide binding]; other site 1206105001938 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1206105001939 active site 1206105001940 uracil binding [chemical binding]; other site 1206105001941 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1206105001942 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1206105001943 motif II; other site 1206105001944 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1206105001945 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1206105001946 Coenzyme A binding pocket [chemical binding]; other site 1206105001947 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1206105001948 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1206105001949 Sugar specificity; other site 1206105001950 Pyrimidine base specificity; other site 1206105001951 ATP-binding site [chemical binding]; other site 1206105001952 PemK-like protein; Region: PemK; pfam02452 1206105001953 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 1206105001954 type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746 1206105001955 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1206105001956 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1206105001957 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1206105001958 HTH domain; Region: HTH_11; pfam08279 1206105001959 HTH domain; Region: HTH_11; pfam08279 1206105001960 PRD domain; Region: PRD; pfam00874 1206105001961 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1206105001962 active site 1206105001963 P-loop; other site 1206105001964 phosphorylation site [posttranslational modification] 1206105001965 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 1206105001966 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; pfam14272 1206105001967 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 1206105001968 Domain of unknown function (DUF4311); Region: DUF4311; cl11919 1206105001969 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 1206105001970 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1206105001971 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1206105001972 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1206105001973 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1206105001974 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 1206105001975 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 1206105001976 active site 1206105001977 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 1206105001978 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1206105001979 catalytic residue [active] 1206105001980 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 1206105001981 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1206105001982 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1206105001983 substrate binding site [chemical binding]; other site 1206105001984 ATP binding site [chemical binding]; other site 1206105001985 DNA gyrase B; Region: DNA_gyraseB; pfam00204 1206105001986 ATP binding site [chemical binding]; other site 1206105001987 hypothetical protein; Validated; Region: PRK00124 1206105001988 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1206105001989 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1206105001990 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1206105001991 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1206105001992 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1206105001993 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1206105001994 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1206105001995 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1206105001996 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1206105001997 ATP binding site [chemical binding]; other site 1206105001998 Mg++ binding site [ion binding]; other site 1206105001999 motif III; other site 1206105002000 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1206105002001 nucleotide binding region [chemical binding]; other site 1206105002002 ATP-binding site [chemical binding]; other site 1206105002003 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1206105002004 alanine racemase; Reviewed; Region: alr; PRK00053 1206105002005 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1206105002006 active site 1206105002007 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1206105002008 dimer interface [polypeptide binding]; other site 1206105002009 substrate binding site [chemical binding]; other site 1206105002010 catalytic residues [active] 1206105002011 PemK-like protein; Region: PemK; pfam02452 1206105002012 hypothetical protein; Provisional; Region: PRK11281 1206105002013 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1206105002014 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1206105002015 Catalytic site [active] 1206105002016 Mga helix-turn-helix domain; Region: Mga; pfam05043 1206105002017 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1206105002018 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1206105002019 Predicted membrane protein [Function unknown]; Region: COG1511 1206105002020 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1206105002021 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1206105002022 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1206105002023 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1206105002024 Amino acid permease; Region: AA_permease_2; pfam13520 1206105002025 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1206105002026 Coenzyme A binding pocket [chemical binding]; other site 1206105002027 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206105002028 dimer interface [polypeptide binding]; other site 1206105002029 conserved gate region; other site 1206105002030 putative PBP binding loops; other site 1206105002031 ABC-ATPase subunit interface; other site 1206105002032 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1206105002033 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1206105002034 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206105002035 dimer interface [polypeptide binding]; other site 1206105002036 conserved gate region; other site 1206105002037 putative PBP binding loops; other site 1206105002038 ABC-ATPase subunit interface; other site 1206105002039 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1206105002040 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1206105002041 Walker A/P-loop; other site 1206105002042 ATP binding site [chemical binding]; other site 1206105002043 Q-loop/lid; other site 1206105002044 ABC transporter signature motif; other site 1206105002045 Walker B; other site 1206105002046 D-loop; other site 1206105002047 H-loop/switch region; other site 1206105002048 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1206105002049 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1206105002050 Zn binding site [ion binding]; other site 1206105002051 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1206105002052 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1206105002053 Zn binding site [ion binding]; other site 1206105002054 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1206105002055 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1206105002056 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1206105002057 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1206105002058 salt bridge; other site 1206105002059 non-specific DNA binding site [nucleotide binding]; other site 1206105002060 sequence-specific DNA binding site [nucleotide binding]; other site 1206105002061 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1206105002062 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1206105002063 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1206105002064 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1206105002065 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1206105002066 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1206105002067 K+ potassium transporter; Region: K_trans; pfam02705 1206105002068 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1206105002069 non-specific DNA binding site [nucleotide binding]; other site 1206105002070 salt bridge; other site 1206105002071 sequence-specific DNA binding site [nucleotide binding]; other site 1206105002072 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1206105002073 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1206105002074 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1206105002075 Mga helix-turn-helix domain; Region: Mga; pfam05043 1206105002076 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1206105002077 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1206105002078 active site 1206105002079 catalytic tetrad [active] 1206105002080 DNA polymerase I; Provisional; Region: PRK05755 1206105002081 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1206105002082 active site 1206105002083 metal binding site 1 [ion binding]; metal-binding site 1206105002084 putative 5' ssDNA interaction site; other site 1206105002085 metal binding site 3; metal-binding site 1206105002086 metal binding site 2 [ion binding]; metal-binding site 1206105002087 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1206105002088 putative DNA binding site [nucleotide binding]; other site 1206105002089 putative metal binding site [ion binding]; other site 1206105002090 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1206105002091 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1206105002092 active site 1206105002093 DNA binding site [nucleotide binding] 1206105002094 catalytic site [active] 1206105002095 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1206105002096 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1206105002097 DNA binding site [nucleotide binding] 1206105002098 catalytic residue [active] 1206105002099 H2TH interface [polypeptide binding]; other site 1206105002100 putative catalytic residues [active] 1206105002101 turnover-facilitating residue; other site 1206105002102 intercalation triad [nucleotide binding]; other site 1206105002103 8OG recognition residue [nucleotide binding]; other site 1206105002104 putative reading head residues; other site 1206105002105 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1206105002106 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1206105002107 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1206105002108 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1206105002109 CoA-binding site [chemical binding]; other site 1206105002110 ATP-binding [chemical binding]; other site 1206105002111 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1206105002112 ATP cone domain; Region: ATP-cone; pfam03477 1206105002113 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1206105002114 primosomal protein DnaI; Reviewed; Region: PRK08939 1206105002115 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1206105002116 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206105002117 Walker A motif; other site 1206105002118 ATP binding site [chemical binding]; other site 1206105002119 Walker B motif; other site 1206105002120 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1206105002121 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 1206105002122 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1206105002123 Helix-turn-helix domain; Region: HTH_38; pfam13936 1206105002124 Integrase core domain; Region: rve; pfam00665 1206105002125 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1206105002126 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1206105002127 DXD motif; other site 1206105002128 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 1206105002129 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 1206105002130 aspartate aminotransferase; Provisional; Region: PRK06348 1206105002131 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1206105002132 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206105002133 homodimer interface [polypeptide binding]; other site 1206105002134 catalytic residue [active] 1206105002135 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1206105002136 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1206105002137 Walker A/P-loop; other site 1206105002138 ATP binding site [chemical binding]; other site 1206105002139 Q-loop/lid; other site 1206105002140 ABC transporter signature motif; other site 1206105002141 Walker B; other site 1206105002142 D-loop; other site 1206105002143 H-loop/switch region; other site 1206105002144 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1206105002145 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1206105002146 substrate binding pocket [chemical binding]; other site 1206105002147 membrane-bound complex binding site; other site 1206105002148 hinge residues; other site 1206105002149 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1206105002150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206105002151 dimer interface [polypeptide binding]; other site 1206105002152 conserved gate region; other site 1206105002153 ABC-ATPase subunit interface; other site 1206105002154 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1206105002155 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 1206105002156 putative active site [active] 1206105002157 metal binding site [ion binding]; metal-binding site 1206105002158 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1206105002159 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1206105002160 Preprotein translocase subunit; Region: YajC; pfam02699 1206105002161 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 1206105002162 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1206105002163 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1206105002164 putative catalytic cysteine [active] 1206105002165 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1206105002166 putative active site [active] 1206105002167 metal binding site [ion binding]; metal-binding site 1206105002168 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1206105002169 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1206105002170 homotetramer interface [polypeptide binding]; other site 1206105002171 FMN binding site [chemical binding]; other site 1206105002172 homodimer contacts [polypeptide binding]; other site 1206105002173 putative active site [active] 1206105002174 putative substrate binding site [chemical binding]; other site 1206105002175 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 1206105002176 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1206105002177 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 1206105002178 diphosphomevalonate decarboxylase; Region: PLN02407 1206105002179 mevalonate kinase; Region: mevalon_kin; TIGR00549 1206105002180 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1206105002181 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1206105002182 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1206105002183 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1206105002184 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1206105002185 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1206105002186 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1206105002187 peptide binding site [polypeptide binding]; other site 1206105002188 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 1206105002189 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1206105002190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206105002191 dimer interface [polypeptide binding]; other site 1206105002192 conserved gate region; other site 1206105002193 putative PBP binding loops; other site 1206105002194 ABC-ATPase subunit interface; other site 1206105002195 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1206105002196 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1206105002197 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206105002198 dimer interface [polypeptide binding]; other site 1206105002199 conserved gate region; other site 1206105002200 putative PBP binding loops; other site 1206105002201 ABC-ATPase subunit interface; other site 1206105002202 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1206105002203 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1206105002204 Walker A/P-loop; other site 1206105002205 ATP binding site [chemical binding]; other site 1206105002206 Q-loop/lid; other site 1206105002207 ABC transporter signature motif; other site 1206105002208 Walker B; other site 1206105002209 D-loop; other site 1206105002210 H-loop/switch region; other site 1206105002211 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1206105002212 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1206105002213 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1206105002214 Walker A/P-loop; other site 1206105002215 ATP binding site [chemical binding]; other site 1206105002216 Q-loop/lid; other site 1206105002217 ABC transporter signature motif; other site 1206105002218 Walker B; other site 1206105002219 D-loop; other site 1206105002220 H-loop/switch region; other site 1206105002221 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1206105002222 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1206105002223 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1206105002224 Probable transposase; Region: OrfB_IS605; pfam01385 1206105002225 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1206105002226 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1206105002227 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1206105002228 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1206105002229 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1206105002230 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1206105002231 23S rRNA binding site [nucleotide binding]; other site 1206105002232 L21 binding site [polypeptide binding]; other site 1206105002233 L13 binding site [polypeptide binding]; other site 1206105002234 Protein of unknown function (DUF419); Region: DUF419; pfam04237 1206105002235 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1206105002236 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1206105002237 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1206105002238 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1206105002239 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1206105002240 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1206105002241 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1206105002242 Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601 1206105002243 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1206105002244 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1206105002245 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1206105002246 dimerization interface [polypeptide binding]; other site 1206105002247 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1206105002248 dimer interface [polypeptide binding]; other site 1206105002249 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1206105002250 dimer interface [polypeptide binding]; other site 1206105002251 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1206105002252 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1206105002253 active site 1206105002254 phosphorylation site [posttranslational modification] 1206105002255 intermolecular recognition site; other site 1206105002256 dimerization interface [polypeptide binding]; other site 1206105002257 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1206105002258 DNA binding site [nucleotide binding] 1206105002259 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1206105002260 dimer interface [polypeptide binding]; other site 1206105002261 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 1206105002262 phosphorylation site [posttranslational modification] 1206105002263 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1206105002264 ATP binding site [chemical binding]; other site 1206105002265 Mg2+ binding site [ion binding]; other site 1206105002266 G-X-G motif; other site 1206105002267 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 1206105002268 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 1206105002269 amino acid transporter; Region: 2A0306; TIGR00909 1206105002270 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1206105002271 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1206105002272 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1206105002273 active site 1206105002274 HIGH motif; other site 1206105002275 KMSKS motif; other site 1206105002276 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1206105002277 tRNA binding surface [nucleotide binding]; other site 1206105002278 anticodon binding site; other site 1206105002279 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1206105002280 dimer interface [polypeptide binding]; other site 1206105002281 putative tRNA-binding site [nucleotide binding]; other site 1206105002282 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1206105002283 Part of AAA domain; Region: AAA_19; pfam13245 1206105002284 Family description; Region: UvrD_C_2; pfam13538 1206105002285 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1206105002286 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1206105002287 active site 1206105002288 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1206105002289 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1206105002290 putative active site [active] 1206105002291 putative metal binding site [ion binding]; other site 1206105002292 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1206105002293 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1206105002294 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206105002295 S-adenosylmethionine binding site [chemical binding]; other site 1206105002296 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1206105002297 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1206105002298 Walker A/P-loop; other site 1206105002299 ATP binding site [chemical binding]; other site 1206105002300 Q-loop/lid; other site 1206105002301 ABC transporter signature motif; other site 1206105002302 Walker B; other site 1206105002303 D-loop; other site 1206105002304 H-loop/switch region; other site 1206105002305 TOBE domain; Region: TOBE_2; pfam08402 1206105002306 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1206105002307 active site 1206105002308 dimer interfaces [polypeptide binding]; other site 1206105002309 catalytic residues [active] 1206105002310 hypothetical protein; Provisional; Region: PRK09609 1206105002311 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1206105002312 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1206105002313 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1206105002314 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1206105002315 Walker A/P-loop; other site 1206105002316 ATP binding site [chemical binding]; other site 1206105002317 Q-loop/lid; other site 1206105002318 ABC transporter signature motif; other site 1206105002319 Walker B; other site 1206105002320 D-loop; other site 1206105002321 H-loop/switch region; other site 1206105002322 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1206105002323 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1206105002324 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206105002325 Walker A/P-loop; other site 1206105002326 ATP binding site [chemical binding]; other site 1206105002327 Q-loop/lid; other site 1206105002328 ABC transporter signature motif; other site 1206105002329 Walker B; other site 1206105002330 D-loop; other site 1206105002331 H-loop/switch region; other site 1206105002332 Predicted membrane protein [Function unknown]; Region: COG4905 1206105002333 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 1206105002334 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1206105002335 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1206105002336 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1206105002337 Coenzyme A binding pocket [chemical binding]; other site 1206105002338 Tubby C 2; Region: Tub_2; cl02043 1206105002339 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1206105002340 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1206105002341 active site 1206105002342 motif I; other site 1206105002343 motif II; other site 1206105002344 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1206105002345 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1206105002346 ligand binding site [chemical binding]; other site 1206105002347 active site 1206105002348 UGI interface [polypeptide binding]; other site 1206105002349 catalytic site [active] 1206105002350 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1206105002351 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1206105002352 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1206105002353 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1206105002354 Coenzyme A binding pocket [chemical binding]; other site 1206105002355 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1206105002356 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1206105002357 DNA binding site [nucleotide binding] 1206105002358 domain linker motif; other site 1206105002359 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 1206105002360 putative dimerization interface [polypeptide binding]; other site 1206105002361 putative ligand binding site [chemical binding]; other site 1206105002362 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1206105002363 active site 1206105002364 catalytic residues [active] 1206105002365 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1206105002366 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1206105002367 motif II; other site 1206105002368 maltose phosphorylase; Provisional; Region: PRK13807 1206105002369 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1206105002370 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1206105002371 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1206105002372 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 1206105002373 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1206105002374 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1206105002375 active site turn [active] 1206105002376 phosphorylation site [posttranslational modification] 1206105002377 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1206105002378 HPr interaction site; other site 1206105002379 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1206105002380 active site 1206105002381 phosphorylation site [posttranslational modification] 1206105002382 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 1206105002383 putative catalytic site [active] 1206105002384 putative metal binding site [ion binding]; other site 1206105002385 putative phosphate binding site [ion binding]; other site 1206105002386 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1206105002387 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 1206105002388 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1206105002389 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1206105002390 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 1206105002391 homodimer interface [polypeptide binding]; other site 1206105002392 chemical substrate binding site [chemical binding]; other site 1206105002393 oligomer interface [polypeptide binding]; other site 1206105002394 metal binding site [ion binding]; metal-binding site 1206105002395 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1206105002396 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1206105002397 active site 1206105002398 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1206105002399 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1206105002400 Protein of unknown function (DUF464); Region: DUF464; pfam04327 1206105002401 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1206105002402 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 1206105002403 phosphodiesterase YaeI; Provisional; Region: PRK11340 1206105002404 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1206105002405 putative active site [active] 1206105002406 putative metal binding site [ion binding]; other site 1206105002407 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1206105002408 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1206105002409 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1206105002410 active site 1206105002411 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 1206105002412 metal binding site [ion binding]; metal-binding site 1206105002413 Asp23 family; Region: Asp23; pfam03780 1206105002414 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1206105002415 putative RNA binding site [nucleotide binding]; other site 1206105002416 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 1206105002417 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1206105002418 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1206105002419 homodimer interface [polypeptide binding]; other site 1206105002420 NADP binding site [chemical binding]; other site 1206105002421 substrate binding site [chemical binding]; other site 1206105002422 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1206105002423 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1206105002424 generic binding surface II; other site 1206105002425 generic binding surface I; other site 1206105002426 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1206105002427 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1206105002428 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1206105002429 substrate binding pocket [chemical binding]; other site 1206105002430 chain length determination region; other site 1206105002431 substrate-Mg2+ binding site; other site 1206105002432 catalytic residues [active] 1206105002433 aspartate-rich region 1; other site 1206105002434 active site lid residues [active] 1206105002435 aspartate-rich region 2; other site 1206105002436 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1206105002437 S4 RNA-binding domain; Region: S4; smart00363 1206105002438 RNA binding surface [nucleotide binding]; other site 1206105002439 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1206105002440 Arginine repressor [Transcription]; Region: ArgR; COG1438 1206105002441 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1206105002442 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1206105002443 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1206105002444 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1206105002445 Walker A/P-loop; other site 1206105002446 ATP binding site [chemical binding]; other site 1206105002447 Q-loop/lid; other site 1206105002448 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1206105002449 ABC transporter signature motif; other site 1206105002450 Walker B; other site 1206105002451 D-loop; other site 1206105002452 H-loop/switch region; other site 1206105002453 Protein of unknown function (DUF4044); Region: DUF4044; pfam13253 1206105002454 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1206105002455 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1206105002456 Cl binding site [ion binding]; other site 1206105002457 oligomer interface [polypeptide binding]; other site 1206105002458 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 1206105002459 MraZ protein; Region: MraZ; pfam02381 1206105002460 MraZ protein; Region: MraZ; pfam02381 1206105002461 MraW methylase family; Region: Methyltransf_5; pfam01795 1206105002462 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1206105002463 Cell division protein FtsL; Region: FtsL; cl11433 1206105002464 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1206105002465 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1206105002466 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1206105002467 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1206105002468 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1206105002469 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1206105002470 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1206105002471 Mg++ binding site [ion binding]; other site 1206105002472 putative catalytic motif [active] 1206105002473 putative substrate binding site [chemical binding]; other site 1206105002474 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1206105002475 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 1206105002476 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1206105002477 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1206105002478 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1206105002479 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1206105002480 active site 1206105002481 homodimer interface [polypeptide binding]; other site 1206105002482 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1206105002483 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1206105002484 Cell division protein FtsQ; Region: FtsQ; pfam03799 1206105002485 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1206105002486 Cell division protein FtsA; Region: FtsA; smart00842 1206105002487 Cell division protein FtsA; Region: FtsA; pfam14450 1206105002488 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 1206105002489 cell division protein FtsZ; Validated; Region: PRK09330 1206105002490 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1206105002491 nucleotide binding site [chemical binding]; other site 1206105002492 SulA interaction site; other site 1206105002493 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1206105002494 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1206105002495 catalytic residue [active] 1206105002496 Protein of unknown function (DUF552); Region: DUF552; pfam04472 1206105002497 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1206105002498 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1206105002499 RNA binding surface [nucleotide binding]; other site 1206105002500 DivIVA protein; Region: DivIVA; pfam05103 1206105002501 DivIVA domain; Region: DivI1A_domain; TIGR03544 1206105002502 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1206105002503 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1206105002504 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1206105002505 active site 1206105002506 HIGH motif; other site 1206105002507 nucleotide binding site [chemical binding]; other site 1206105002508 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1206105002509 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1206105002510 active site 1206105002511 KMSKS motif; other site 1206105002512 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1206105002513 tRNA binding surface [nucleotide binding]; other site 1206105002514 anticodon binding site; other site 1206105002515 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1206105002516 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1206105002517 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1206105002518 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1206105002519 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1206105002520 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1206105002521 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1206105002522 FeoA domain; Region: FeoA; pfam04023 1206105002523 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1206105002524 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1206105002525 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1206105002526 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1206105002527 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1206105002528 ATP binding site [chemical binding]; other site 1206105002529 putative Mg++ binding site [ion binding]; other site 1206105002530 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1206105002531 nucleotide binding region [chemical binding]; other site 1206105002532 ATP-binding site [chemical binding]; other site 1206105002533 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1206105002534 putative Zn2+ binding site [ion binding]; other site 1206105002535 putative DNA binding site [nucleotide binding]; other site 1206105002536 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206105002537 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1206105002538 Walker A motif; other site 1206105002539 ATP binding site [chemical binding]; other site 1206105002540 Walker B motif; other site 1206105002541 arginine finger; other site 1206105002542 Transcriptional antiterminator [Transcription]; Region: COG3933 1206105002543 PRD domain; Region: PRD; pfam00874 1206105002544 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1206105002545 active pocket/dimerization site; other site 1206105002546 active site 1206105002547 phosphorylation site [posttranslational modification] 1206105002548 PRD domain; Region: PRD; pfam00874 1206105002549 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1206105002550 active site 1206105002551 P-loop; other site 1206105002552 phosphorylation site [posttranslational modification] 1206105002553 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1206105002554 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1206105002555 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 1206105002556 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1206105002557 active site 1206105002558 P-loop; other site 1206105002559 phosphorylation site [posttranslational modification] 1206105002560 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1206105002561 active site 1206105002562 methionine cluster; other site 1206105002563 phosphorylation site [posttranslational modification] 1206105002564 metal binding site [ion binding]; metal-binding site 1206105002565 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1206105002566 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1206105002567 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1206105002568 beta-galactosidase; Region: BGL; TIGR03356 1206105002569 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1206105002570 Sterol carrier protein domain; Region: SCP2_2; pfam13530 1206105002571 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1206105002572 pyruvate, phosphate dikinase; Region: pyru_phos_dikin; TIGR01828 1206105002573 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1206105002574 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1206105002575 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1206105002576 HTH domain; Region: HTH_11; pfam08279 1206105002577 FOG: CBS domain [General function prediction only]; Region: COG0517 1206105002578 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 1206105002579 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 1206105002580 Predicted integral membrane protein [Function unknown]; Region: COG0392 1206105002581 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1206105002582 Keratinocyte-associated protein 2; Region: Keratin_assoc; pfam09775 1206105002583 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1206105002584 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1206105002585 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1206105002586 AAA domain; Region: AAA_17; cl17253 1206105002587 AAA domain; Region: AAA_18; pfam13238 1206105002588 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1206105002589 putative catalytic site [active] 1206105002590 putative metal binding site [ion binding]; other site 1206105002591 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1206105002592 putative catalytic site [active] 1206105002593 putative phosphate binding site [ion binding]; other site 1206105002594 putative phosphate binding site [ion binding]; other site 1206105002595 putative metal binding site [ion binding]; other site 1206105002596 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206105002597 Walker A/P-loop; other site 1206105002598 ATP binding site [chemical binding]; other site 1206105002599 Q-loop/lid; other site 1206105002600 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1206105002601 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1206105002602 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206105002603 Walker A/P-loop; other site 1206105002604 ATP binding site [chemical binding]; other site 1206105002605 Q-loop/lid; other site 1206105002606 ABC transporter signature motif; other site 1206105002607 Walker B; other site 1206105002608 D-loop; other site 1206105002609 H-loop/switch region; other site 1206105002610 amidase; Provisional; Region: PRK06529 1206105002611 Amidase; Region: Amidase; cl11426 1206105002612 Phosphotransferase enzyme family; Region: APH; pfam01636 1206105002613 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1206105002614 active site 1206105002615 ATP binding site [chemical binding]; other site 1206105002616 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1206105002617 active site 1206105002618 multimer interface [polypeptide binding]; other site 1206105002619 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 1206105002620 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1206105002621 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206105002622 homodimer interface [polypeptide binding]; other site 1206105002623 catalytic residue [active] 1206105002624 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1206105002625 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1206105002626 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1206105002627 active site 1206105002628 motif I; other site 1206105002629 motif II; other site 1206105002630 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 1206105002631 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1206105002632 drug efflux system protein MdtG; Provisional; Region: PRK09874 1206105002633 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206105002634 putative substrate translocation pore; other site 1206105002635 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1206105002636 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 1206105002637 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1206105002638 active site 1206105002639 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1206105002640 generic binding surface II; other site 1206105002641 generic binding surface I; other site 1206105002642 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1206105002643 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1206105002644 active site 1206105002645 ADP/pyrophosphate binding site [chemical binding]; other site 1206105002646 dimerization interface [polypeptide binding]; other site 1206105002647 allosteric effector site; other site 1206105002648 fructose-1,6-bisphosphate binding site; other site 1206105002649 pyruvate kinase; Provisional; Region: PRK06354 1206105002650 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1206105002651 domain interfaces; other site 1206105002652 active site 1206105002653 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1206105002654 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1206105002655 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1206105002656 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1206105002657 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1206105002658 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1206105002659 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1206105002660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1206105002661 active site 1206105002662 phosphorylation site [posttranslational modification] 1206105002663 intermolecular recognition site; other site 1206105002664 dimerization interface [polypeptide binding]; other site 1206105002665 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1206105002666 DNA binding site [nucleotide binding] 1206105002667 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1206105002668 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1206105002669 dimerization interface [polypeptide binding]; other site 1206105002670 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1206105002671 dimer interface [polypeptide binding]; other site 1206105002672 phosphorylation site [posttranslational modification] 1206105002673 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1206105002674 ATP binding site [chemical binding]; other site 1206105002675 Mg2+ binding site [ion binding]; other site 1206105002676 G-X-G motif; other site 1206105002677 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1206105002678 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1206105002679 Walker A/P-loop; other site 1206105002680 ATP binding site [chemical binding]; other site 1206105002681 Q-loop/lid; other site 1206105002682 ABC transporter signature motif; other site 1206105002683 Walker B; other site 1206105002684 D-loop; other site 1206105002685 H-loop/switch region; other site 1206105002686 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 1206105002687 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206105002688 dimer interface [polypeptide binding]; other site 1206105002689 conserved gate region; other site 1206105002690 putative PBP binding loops; other site 1206105002691 ABC-ATPase subunit interface; other site 1206105002692 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206105002693 dimer interface [polypeptide binding]; other site 1206105002694 conserved gate region; other site 1206105002695 ABC-ATPase subunit interface; other site 1206105002696 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1206105002697 AAA domain; Region: AAA_33; pfam13671 1206105002698 active site 1206105002699 AAA domain; Region: AAA_33; pfam13671 1206105002700 manganese transport protein MntH; Reviewed; Region: PRK00701 1206105002701 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1206105002702 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1206105002703 Ligand Binding Site [chemical binding]; other site 1206105002704 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1206105002705 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1206105002706 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1206105002707 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1206105002708 peptide binding site [polypeptide binding]; other site 1206105002709 putative deaminase; Validated; Region: PRK06846 1206105002710 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1206105002711 active site 1206105002712 putative deaminase; Validated; Region: PRK06846 1206105002713 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1206105002714 active site 1206105002715 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1206105002716 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1206105002717 dimer interface [polypeptide binding]; other site 1206105002718 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1206105002719 maltose O-acetyltransferase; Provisional; Region: PRK10092 1206105002720 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1206105002721 active site 1206105002722 substrate binding site [chemical binding]; other site 1206105002723 trimer interface [polypeptide binding]; other site 1206105002724 CoA binding site [chemical binding]; other site 1206105002725 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1206105002726 active site 1206105002727 catalytic residues [active] 1206105002728 galactokinase; Provisional; Region: PRK05322 1206105002729 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1206105002730 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1206105002731 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1206105002732 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1206105002733 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1206105002734 NAD binding site [chemical binding]; other site 1206105002735 homodimer interface [polypeptide binding]; other site 1206105002736 active site 1206105002737 substrate binding site [chemical binding]; other site 1206105002738 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 1206105002739 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 1206105002740 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 1206105002741 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1206105002742 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1206105002743 DNA binding site [nucleotide binding] 1206105002744 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1206105002745 putative ligand binding site [chemical binding]; other site 1206105002746 putative dimerization interface [polypeptide binding]; other site 1206105002747 hypothetical protein; Provisional; Region: PRK06762 1206105002748 AAA domain; Region: AAA_33; pfam13671 1206105002749 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1206105002750 Coenzyme A binding pocket [chemical binding]; other site 1206105002751 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1206105002752 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1206105002753 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1206105002754 Coenzyme A binding pocket [chemical binding]; other site 1206105002755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206105002756 putative substrate translocation pore; other site 1206105002757 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1206105002758 DNA polymerase IV; Reviewed; Region: PRK03103 1206105002759 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1206105002760 active site 1206105002761 DNA binding site [nucleotide binding] 1206105002762 Protein of unknown function (DUF3016); Region: DUF3016; pfam11454 1206105002763 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1206105002764 Ligand Binding Site [chemical binding]; other site 1206105002765 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1206105002766 Coenzyme A binding pocket [chemical binding]; other site 1206105002767 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1206105002768 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1206105002769 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1206105002770 Mga helix-turn-helix domain; Region: Mga; pfam05043 1206105002771 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1206105002772 metal ion-dependent adhesion site (MIDAS); other site 1206105002773 Cna protein B-type domain; Region: Cna_B; pfam05738 1206105002774 Cna protein B-type domain; Region: Cna_B; pfam05738 1206105002775 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1206105002776 Cna protein B-type domain; Region: Cna_B; pfam05738 1206105002777 Cna protein B-type domain; Region: Cna_B; pfam05738 1206105002778 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1206105002779 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1206105002780 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1206105002781 active site 1206105002782 catalytic site [active] 1206105002783 Domain of unknown function (DUF378); Region: DUF378; pfam04070 1206105002784 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 1206105002785 Collagen binding domain; Region: Collagen_bind; pfam05737 1206105002786 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 1206105002787 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1206105002788 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206105002789 Walker A/P-loop; other site 1206105002790 ATP binding site [chemical binding]; other site 1206105002791 Q-loop/lid; other site 1206105002792 ABC transporter signature motif; other site 1206105002793 Walker B; other site 1206105002794 D-loop; other site 1206105002795 H-loop/switch region; other site 1206105002796 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206105002797 S-adenosylmethionine binding site [chemical binding]; other site 1206105002798 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 1206105002799 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1206105002800 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 1206105002801 Cysteine-rich domain; Region: CCG; pfam02754 1206105002802 Cysteine-rich domain; Region: CCG; pfam02754 1206105002803 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1206105002804 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1206105002805 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1206105002806 Uncharacterized conserved protein [Function unknown]; Region: COG1556 1206105002807 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1206105002808 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1206105002809 Catalytic site [active] 1206105002810 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1206105002811 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1206105002812 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1206105002813 Part of AAA domain; Region: AAA_19; pfam13245 1206105002814 Family description; Region: UvrD_C_2; pfam13538 1206105002815 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1206105002816 Predicted transcriptional regulators [Transcription]; Region: COG1733 1206105002817 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1206105002818 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1206105002819 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1206105002820 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1206105002821 dimer interface [polypeptide binding]; other site 1206105002822 motif 1; other site 1206105002823 active site 1206105002824 motif 2; other site 1206105002825 motif 3; other site 1206105002826 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1206105002827 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1206105002828 putative tRNA-binding site [nucleotide binding]; other site 1206105002829 B3/4 domain; Region: B3_4; pfam03483 1206105002830 tRNA synthetase B5 domain; Region: B5; smart00874 1206105002831 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1206105002832 dimer interface [polypeptide binding]; other site 1206105002833 motif 1; other site 1206105002834 motif 3; other site 1206105002835 motif 2; other site 1206105002836 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1206105002837 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1206105002838 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206105002839 dimer interface [polypeptide binding]; other site 1206105002840 conserved gate region; other site 1206105002841 putative PBP binding loops; other site 1206105002842 ABC-ATPase subunit interface; other site 1206105002843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206105002844 dimer interface [polypeptide binding]; other site 1206105002845 conserved gate region; other site 1206105002846 putative PBP binding loops; other site 1206105002847 ABC-ATPase subunit interface; other site 1206105002848 bifunctional adhesin/ABC transporter aspartate/glutamate-binding protein; Reviewed; Region: PRK11917 1206105002849 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1206105002850 substrate binding pocket [chemical binding]; other site 1206105002851 membrane-bound complex binding site; other site 1206105002852 hinge residues; other site 1206105002853 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1206105002854 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1206105002855 Walker A/P-loop; other site 1206105002856 ATP binding site [chemical binding]; other site 1206105002857 Q-loop/lid; other site 1206105002858 ABC transporter signature motif; other site 1206105002859 Walker B; other site 1206105002860 D-loop; other site 1206105002861 H-loop/switch region; other site 1206105002862 glutamate racemase; Provisional; Region: PRK00865 1206105002863 ribonuclease PH; Reviewed; Region: rph; PRK00173 1206105002864 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1206105002865 hexamer interface [polypeptide binding]; other site 1206105002866 active site 1206105002867 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1206105002868 active site 1206105002869 dimerization interface [polypeptide binding]; other site 1206105002870 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 1206105002871 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1206105002872 active site 1206105002873 metal binding site [ion binding]; metal-binding site 1206105002874 homotetramer interface [polypeptide binding]; other site 1206105002875 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1206105002876 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1206105002877 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1206105002878 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 1206105002879 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1206105002880 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1206105002881 active site 1206105002882 phosphorylation site [posttranslational modification] 1206105002883 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 1206105002884 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1206105002885 active site 1206105002886 P-loop; other site 1206105002887 phosphorylation site [posttranslational modification] 1206105002888 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1206105002889 active site 1206105002890 dimer interface [polypeptide binding]; other site 1206105002891 magnesium binding site [ion binding]; other site 1206105002892 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 1206105002893 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1206105002894 AP (apurinic/apyrimidinic) site pocket; other site 1206105002895 DNA interaction; other site 1206105002896 Metal-binding active site; metal-binding site 1206105002897 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1206105002898 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1206105002899 intersubunit interface [polypeptide binding]; other site 1206105002900 active site 1206105002901 Zn2+ binding site [ion binding]; other site 1206105002902 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 1206105002903 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1206105002904 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1206105002905 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1206105002906 active site 1206105002907 trimer interface [polypeptide binding]; other site 1206105002908 substrate binding site [chemical binding]; other site 1206105002909 CoA binding site [chemical binding]; other site 1206105002910 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1206105002911 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 1206105002912 metal binding site [ion binding]; metal-binding site 1206105002913 putative dimer interface [polypeptide binding]; other site 1206105002914 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1206105002915 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1206105002916 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1206105002917 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1206105002918 active site 1206105002919 catalytic tetrad [active] 1206105002920 Peptidase C26; Region: Peptidase_C26; pfam07722 1206105002921 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1206105002922 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1206105002923 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1206105002924 dimer interface [polypeptide binding]; other site 1206105002925 active site 1206105002926 metal binding site [ion binding]; metal-binding site 1206105002927 glutathione binding site [chemical binding]; other site 1206105002928 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 1206105002929 nudix motif; other site 1206105002930 sugar phosphate phosphatase; Provisional; Region: PRK10513 1206105002931 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1206105002932 active site 1206105002933 motif I; other site 1206105002934 motif II; other site 1206105002935 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1206105002936 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1206105002937 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1206105002938 Zn2+ binding site [ion binding]; other site 1206105002939 Mg2+ binding site [ion binding]; other site 1206105002940 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1206105002941 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 1206105002942 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1206105002943 CTP synthetase; Validated; Region: pyrG; PRK05380 1206105002944 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1206105002945 Catalytic site [active] 1206105002946 active site 1206105002947 UTP binding site [chemical binding]; other site 1206105002948 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1206105002949 active site 1206105002950 putative oxyanion hole; other site 1206105002951 catalytic triad [active] 1206105002952 Transglycosylase; Region: Transgly; pfam00912 1206105002953 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1206105002954 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1206105002955 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1206105002956 hypothetical protein; Provisional; Region: PRK13660 1206105002957 cell division protein GpsB; Provisional; Region: PRK14127 1206105002958 DivIVA domain; Region: DivI1A_domain; TIGR03544 1206105002959 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1206105002960 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1206105002961 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1206105002962 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1206105002963 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1206105002964 active site 1206105002965 Zn binding site [ion binding]; other site 1206105002966 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1206105002967 Helix-turn-helix domain; Region: HTH_36; pfam13730 1206105002968 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1206105002969 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1206105002970 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1206105002971 minor groove reading motif; other site 1206105002972 helix-hairpin-helix signature motif; other site 1206105002973 substrate binding pocket [chemical binding]; other site 1206105002974 active site 1206105002975 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1206105002976 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1206105002977 DNA-binding site [nucleotide binding]; DNA binding site 1206105002978 UTRA domain; Region: UTRA; pfam07702 1206105002979 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1206105002980 dipeptidase, putative; Region: dipeptidaselike; TIGR01887 1206105002981 active site 1206105002982 metal binding site [ion binding]; metal-binding site 1206105002983 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 1206105002984 active site 1206105002985 dimer interface [polypeptide binding]; other site 1206105002986 catalytic nucleophile [active] 1206105002987 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1206105002988 active site 1206105002989 P-loop; other site 1206105002990 phosphorylation site [posttranslational modification] 1206105002991 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1206105002992 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1206105002993 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 1206105002994 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1206105002995 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1206105002996 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1206105002997 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1206105002998 active site 1206105002999 homotetramer interface [polypeptide binding]; other site 1206105003000 homodimer interface [polypeptide binding]; other site 1206105003001 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1206105003002 Zn2+ binding site [ion binding]; other site 1206105003003 Mg2+ binding site [ion binding]; other site 1206105003004 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1206105003005 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1206105003006 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1206105003007 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1206105003008 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1206105003009 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1206105003010 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1206105003011 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1206105003012 intersubunit interface [polypeptide binding]; other site 1206105003013 active site 1206105003014 zinc binding site [ion binding]; other site 1206105003015 Na+ binding site [ion binding]; other site 1206105003016 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1206105003017 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1206105003018 hinge; other site 1206105003019 active site 1206105003020 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1206105003021 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1206105003022 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1206105003023 RNA binding site [nucleotide binding]; other site 1206105003024 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1206105003025 multimer interface [polypeptide binding]; other site 1206105003026 Walker A motif; other site 1206105003027 ATP binding site [chemical binding]; other site 1206105003028 Walker B motif; other site 1206105003029 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1206105003030 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1206105003031 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 1206105003032 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1206105003033 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1206105003034 nucleotide binding site [chemical binding]; other site 1206105003035 CsbD-like; Region: CsbD; cl17424 1206105003036 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1206105003037 dimer interface [polypeptide binding]; other site 1206105003038 FMN binding site [chemical binding]; other site 1206105003039 NADPH bind site [chemical binding]; other site 1206105003040 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1206105003041 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1206105003042 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1206105003043 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1206105003044 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1206105003045 dimer interface [polypeptide binding]; other site 1206105003046 active site 1206105003047 catalytic residue [active] 1206105003048 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1206105003049 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1206105003050 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1206105003051 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1206105003052 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1206105003053 active site 1206105003054 metal binding site [ion binding]; metal-binding site 1206105003055 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1206105003056 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 1206105003057 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 1206105003058 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1206105003059 active site 1206105003060 motif I; other site 1206105003061 motif II; other site 1206105003062 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1206105003063 integral membrane protein TIGR01906; Region: integ_TIGR01906 1206105003064 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 1206105003065 EDD domain protein, DegV family; Region: DegV; TIGR00762 1206105003066 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1206105003067 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1206105003068 amphipathic channel; other site 1206105003069 Asn-Pro-Ala signature motifs; other site 1206105003070 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1206105003071 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1206105003072 active site 1206105003073 phosphorylation site [posttranslational modification] 1206105003074 intermolecular recognition site; other site 1206105003075 dimerization interface [polypeptide binding]; other site 1206105003076 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1206105003077 DNA binding site [nucleotide binding] 1206105003078 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1206105003079 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1206105003080 dimerization interface [polypeptide binding]; other site 1206105003081 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1206105003082 putative active site [active] 1206105003083 heme pocket [chemical binding]; other site 1206105003084 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1206105003085 dimer interface [polypeptide binding]; other site 1206105003086 phosphorylation site [posttranslational modification] 1206105003087 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1206105003088 ATP binding site [chemical binding]; other site 1206105003089 Mg2+ binding site [ion binding]; other site 1206105003090 G-X-G motif; other site 1206105003091 YycH protein; Region: YycH; pfam07435 1206105003092 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1206105003093 YycH protein; Region: YycI; pfam09648 1206105003094 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1206105003095 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1206105003096 Predicted permeases [General function prediction only]; Region: COG0701 1206105003097 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 1206105003098 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 1206105003099 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1206105003100 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1206105003101 hypothetical protein; Provisional; Region: PRK05473 1206105003102 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1206105003103 hypothetical protein; Provisional; Region: PRK13678 1206105003104 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1206105003105 non-specific DNA binding site [nucleotide binding]; other site 1206105003106 salt bridge; other site 1206105003107 sequence-specific DNA binding site [nucleotide binding]; other site 1206105003108 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1206105003109 binding surface 1206105003110 TPR motif; other site 1206105003111 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1206105003112 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1206105003113 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1206105003114 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1206105003115 putative NAD(P) binding site [chemical binding]; other site 1206105003116 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 1206105003117 PAS domain S-box; Region: sensory_box; TIGR00229 1206105003118 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1206105003119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1206105003120 active site 1206105003121 phosphorylation site [posttranslational modification] 1206105003122 intermolecular recognition site; other site 1206105003123 dimerization interface [polypeptide binding]; other site 1206105003124 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1206105003125 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1206105003126 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1206105003127 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1206105003128 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1206105003129 acetolactate synthase; Reviewed; Region: PRK08617 1206105003130 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1206105003131 PYR/PP interface [polypeptide binding]; other site 1206105003132 dimer interface [polypeptide binding]; other site 1206105003133 TPP binding site [chemical binding]; other site 1206105003134 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1206105003135 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1206105003136 TPP-binding site [chemical binding]; other site 1206105003137 dimer interface [polypeptide binding]; other site 1206105003138 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 1206105003139 PQQ-like domain; Region: PQQ_2; pfam13360 1206105003140 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1206105003141 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1206105003142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206105003143 dimer interface [polypeptide binding]; other site 1206105003144 conserved gate region; other site 1206105003145 putative PBP binding loops; other site 1206105003146 ABC-ATPase subunit interface; other site 1206105003147 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1206105003148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206105003149 dimer interface [polypeptide binding]; other site 1206105003150 conserved gate region; other site 1206105003151 putative PBP binding loops; other site 1206105003152 ABC-ATPase subunit interface; other site 1206105003153 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1206105003154 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206105003155 Walker A/P-loop; other site 1206105003156 ATP binding site [chemical binding]; other site 1206105003157 Q-loop/lid; other site 1206105003158 ABC transporter signature motif; other site 1206105003159 Walker B; other site 1206105003160 D-loop; other site 1206105003161 H-loop/switch region; other site 1206105003162 TOBE domain; Region: TOBE_2; pfam08402 1206105003163 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1206105003164 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1206105003165 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1206105003166 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1206105003167 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1206105003168 active site 1206105003169 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1206105003170 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1206105003171 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 1206105003172 active site 1206105003173 putative substrate binding pocket [chemical binding]; other site 1206105003174 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1206105003175 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1206105003176 non-specific DNA binding site [nucleotide binding]; other site 1206105003177 salt bridge; other site 1206105003178 sequence-specific DNA binding site [nucleotide binding]; other site 1206105003179 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1206105003180 ApbE family; Region: ApbE; pfam02424 1206105003181 Predicted flavoprotein [General function prediction only]; Region: COG0431 1206105003182 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1206105003183 Predicted flavoprotein [General function prediction only]; Region: COG0431 1206105003184 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1206105003185 PAS domain; Region: PAS_10; pfam13596 1206105003186 Mga helix-turn-helix domain; Region: Mga; pfam05043 1206105003187 DNA-binding domain found in transcription regulators in plants such as APETALA2 and EREBP (ethylene responsive element binding protein). In EREBPs the domain specifically binds to the 11bp GCC box of the ethylene response element (ERE), a promotor...; Region: AP2; cl00033 1206105003188 DNA binding site [nucleotide binding] 1206105003189 phosphodiesterase YaeI; Provisional; Region: PRK11340 1206105003190 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1206105003191 putative active site [active] 1206105003192 putative metal binding site [ion binding]; other site 1206105003193 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1206105003194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206105003195 dimer interface [polypeptide binding]; other site 1206105003196 conserved gate region; other site 1206105003197 ABC-ATPase subunit interface; other site 1206105003198 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1206105003199 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206105003200 dimer interface [polypeptide binding]; other site 1206105003201 conserved gate region; other site 1206105003202 ABC-ATPase subunit interface; other site 1206105003203 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1206105003204 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 1206105003205 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1206105003206 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 1206105003207 putative catalytic site [active] 1206105003208 putative metal binding site [ion binding]; other site 1206105003209 putative phosphate binding site [ion binding]; other site 1206105003210 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1206105003211 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1206105003212 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1206105003213 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 1206105003214 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1206105003215 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1206105003216 DNA binding site [nucleotide binding] 1206105003217 domain linker motif; other site 1206105003218 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1206105003219 dimerization interface [polypeptide binding]; other site 1206105003220 ligand binding site [chemical binding]; other site 1206105003221 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1206105003222 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1206105003223 DNA-binding site [nucleotide binding]; DNA binding site 1206105003224 UTRA domain; Region: UTRA; pfam07702 1206105003225 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1206105003226 beta-galactosidase; Region: BGL; TIGR03356 1206105003227 putative oxidoreductase; Provisional; Region: PRK10206 1206105003228 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1206105003229 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1206105003230 Protein of unknown function (DUF441); Region: DUF441; pfam04284 1206105003231 glycoprotein BALF4; Provisional; Region: PHA03231 1206105003232 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1206105003233 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1206105003234 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 1206105003235 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1206105003236 zinc binding site [ion binding]; other site 1206105003237 putative ligand binding site [chemical binding]; other site 1206105003238 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1206105003239 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 1206105003240 TM-ABC transporter signature motif; other site 1206105003241 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 1206105003242 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206105003243 Walker A/P-loop; other site 1206105003244 ATP binding site [chemical binding]; other site 1206105003245 Q-loop/lid; other site 1206105003246 ABC transporter signature motif; other site 1206105003247 Walker B; other site 1206105003248 D-loop; other site 1206105003249 H-loop/switch region; other site 1206105003250 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1206105003251 Helix-turn-helix domain; Region: HTH_28; pfam13518 1206105003252 Helix-turn-helix domain; Region: HTH_28; pfam13518 1206105003253 HTH-like domain; Region: HTH_21; pfam13276 1206105003254 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1206105003255 Integrase core domain; Region: rve; pfam00665 1206105003256 Integrase core domain; Region: rve_2; pfam13333 1206105003257 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 1206105003258 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1206105003259 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1206105003260 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1206105003261 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1206105003262 active site 1206105003263 motif I; other site 1206105003264 motif II; other site 1206105003265 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1206105003266 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1206105003267 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1206105003268 active site 1206105003269 phosphorylation site [posttranslational modification] 1206105003270 intermolecular recognition site; other site 1206105003271 dimerization interface [polypeptide binding]; other site 1206105003272 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1206105003273 DNA binding site [nucleotide binding] 1206105003274 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1206105003275 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1206105003276 dimerization interface [polypeptide binding]; other site 1206105003277 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1206105003278 dimer interface [polypeptide binding]; other site 1206105003279 phosphorylation site [posttranslational modification] 1206105003280 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1206105003281 ATP binding site [chemical binding]; other site 1206105003282 G-X-G motif; other site 1206105003283 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206105003284 Q-loop/lid; other site 1206105003285 ABC transporter signature motif; other site 1206105003286 Walker B; other site 1206105003287 D-loop; other site 1206105003288 H-loop/switch region; other site 1206105003289 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1206105003290 Sulfatase; Region: Sulfatase; pfam00884 1206105003291 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1206105003292 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1206105003293 putative RNA binding site [nucleotide binding]; other site 1206105003294 ribonuclease HIII; Provisional; Region: PRK00996 1206105003295 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1206105003296 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1206105003297 RNA/DNA hybrid binding site [nucleotide binding]; other site 1206105003298 active site 1206105003299 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1206105003300 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1206105003301 Collagen binding domain; Region: Collagen_bind; pfam05737 1206105003302 Cna protein B-type domain; Region: Cna_B; pfam05738 1206105003303 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 1206105003304 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1206105003305 Sm and related proteins; Region: Sm_like; cl00259 1206105003306 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1206105003307 putative oligomer interface [polypeptide binding]; other site 1206105003308 putative RNA binding site [nucleotide binding]; other site 1206105003309 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1206105003310 NusA N-terminal domain; Region: NusA_N; pfam08529 1206105003311 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1206105003312 RNA binding site [nucleotide binding]; other site 1206105003313 homodimer interface [polypeptide binding]; other site 1206105003314 NusA-like KH domain; Region: KH_5; pfam13184 1206105003315 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1206105003316 G-X-X-G motif; other site 1206105003317 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1206105003318 putative RNA binding cleft [nucleotide binding]; other site 1206105003319 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1206105003320 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1206105003321 translation initiation factor IF-2; Region: IF-2; TIGR00487 1206105003322 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1206105003323 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1206105003324 G1 box; other site 1206105003325 putative GEF interaction site [polypeptide binding]; other site 1206105003326 GTP/Mg2+ binding site [chemical binding]; other site 1206105003327 Switch I region; other site 1206105003328 G2 box; other site 1206105003329 G3 box; other site 1206105003330 Switch II region; other site 1206105003331 G4 box; other site 1206105003332 G5 box; other site 1206105003333 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1206105003334 Translation-initiation factor 2; Region: IF-2; pfam11987 1206105003335 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1206105003336 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1206105003337 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1206105003338 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1206105003339 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1206105003340 non-specific DNA binding site [nucleotide binding]; other site 1206105003341 salt bridge; other site 1206105003342 sequence-specific DNA binding site [nucleotide binding]; other site 1206105003343 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 1206105003344 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206105003345 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1206105003346 Walker A motif; other site 1206105003347 ATP binding site [chemical binding]; other site 1206105003348 Walker B motif; other site 1206105003349 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 1206105003350 Phage major tail protein 2; Region: Phage_tail_2; cl11463 1206105003351 Phage protein; Region: DUF3647; pfam12363 1206105003352 Phage-related protein [Function unknown]; Region: COG5412 1206105003353 Phage tail protein; Region: Sipho_tail; pfam05709 1206105003354 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1206105003355 Holin family; Region: Phage_holin_4; pfam05105 1206105003356 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1206105003357 amidase catalytic site [active] 1206105003358 Zn binding residues [ion binding]; other site 1206105003359 substrate binding site [chemical binding]; other site 1206105003360 Bacterial SH3 domain; Region: SH3_5; pfam08460 1206105003361 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 1206105003362 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1206105003363 RNA binding site [nucleotide binding]; other site 1206105003364 active site 1206105003365 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1206105003366 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1206105003367 active site 1206105003368 Riboflavin kinase; Region: Flavokinase; smart00904 1206105003369 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1206105003370 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1206105003371 Coenzyme A binding pocket [chemical binding]; other site 1206105003372 Predicted transcriptional regulators [Transcription]; Region: COG1695 1206105003373 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1206105003374 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 1206105003375 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 1206105003376 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1206105003377 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1206105003378 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1206105003379 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1206105003380 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1206105003381 dimerization interface [polypeptide binding]; other site 1206105003382 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1206105003383 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1206105003384 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1206105003385 dimerization interface [polypeptide binding]; other site 1206105003386 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1206105003387 magnesium-transporting ATPase; Provisional; Region: PRK15122 1206105003388 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1206105003389 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1206105003390 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1206105003391 motif II; other site 1206105003392 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1206105003393 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 1206105003394 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1206105003395 FeS/SAM binding site; other site 1206105003396 HemN C-terminal domain; Region: HemN_C; pfam06969 1206105003397 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1206105003398 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1206105003399 GrpE; Region: GrpE; pfam01025 1206105003400 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1206105003401 dimer interface [polypeptide binding]; other site 1206105003402 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1206105003403 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1206105003404 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1206105003405 nucleotide binding site [chemical binding]; other site 1206105003406 NEF interaction site [polypeptide binding]; other site 1206105003407 SBD interface [polypeptide binding]; other site 1206105003408 chaperone protein DnaJ; Provisional; Region: PRK14276 1206105003409 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1206105003410 HSP70 interaction site [polypeptide binding]; other site 1206105003411 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1206105003412 substrate binding site [polypeptide binding]; other site 1206105003413 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1206105003414 Zn binding sites [ion binding]; other site 1206105003415 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1206105003416 substrate binding site [polypeptide binding]; other site 1206105003417 dimer interface [polypeptide binding]; other site 1206105003418 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1206105003419 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 1206105003420 active site 1206105003421 metal binding site [ion binding]; metal-binding site 1206105003422 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1206105003423 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1206105003424 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1206105003425 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1206105003426 RNA binding site [nucleotide binding]; other site 1206105003427 hypothetical protein; Provisional; Region: PRK04351 1206105003428 SprT homologues; Region: SprT; cl01182 1206105003429 aminotransferase AlaT; Validated; Region: PRK09265 1206105003430 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1206105003431 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206105003432 homodimer interface [polypeptide binding]; other site 1206105003433 catalytic residue [active] 1206105003434 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1206105003435 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1206105003436 non-specific DNA binding site [nucleotide binding]; other site 1206105003437 salt bridge; other site 1206105003438 sequence-specific DNA binding site [nucleotide binding]; other site 1206105003439 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1206105003440 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1206105003441 active site 1206105003442 dimer interface [polypeptide binding]; other site 1206105003443 nitrogenase reductase; Reviewed; Region: nifH; PRK13235 1206105003444 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 1206105003445 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1206105003446 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1206105003447 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1206105003448 Walker A/P-loop; other site 1206105003449 ATP binding site [chemical binding]; other site 1206105003450 Q-loop/lid; other site 1206105003451 ABC transporter signature motif; other site 1206105003452 Walker B; other site 1206105003453 D-loop; other site 1206105003454 H-loop/switch region; other site 1206105003455 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1206105003456 FtsX-like permease family; Region: FtsX; pfam02687 1206105003457 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1206105003458 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1206105003459 FtsX-like permease family; Region: FtsX; pfam02687 1206105003460 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1206105003461 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1206105003462 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 1206105003463 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1206105003464 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206105003465 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1206105003466 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1206105003467 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 1206105003468 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1206105003469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 1206105003470 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 1206105003471 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 1206105003472 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1206105003473 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1206105003474 DNA-binding site [nucleotide binding]; DNA binding site 1206105003475 UTRA domain; Region: UTRA; pfam07702 1206105003476 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1206105003477 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1206105003478 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 1206105003479 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 1206105003480 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 1206105003481 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1206105003482 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1206105003483 LXG domain of WXG superfamily; Region: LXG; pfam04740 1206105003484 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1206105003485 Helix-turn-helix domain; Region: HTH_38; pfam13936 1206105003486 Integrase core domain; Region: rve; pfam00665 1206105003487 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1206105003488 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1206105003489 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1206105003490 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1206105003491 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1206105003492 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1206105003493 Walker A/P-loop; other site 1206105003494 ATP binding site [chemical binding]; other site 1206105003495 Q-loop/lid; other site 1206105003496 ABC transporter signature motif; other site 1206105003497 Walker B; other site 1206105003498 D-loop; other site 1206105003499 H-loop/switch region; other site 1206105003500 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1206105003501 FtsX-like permease family; Region: FtsX; pfam02687 1206105003502 MarR family; Region: MarR_2; pfam12802 1206105003503 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1206105003504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206105003505 dimer interface [polypeptide binding]; other site 1206105003506 conserved gate region; other site 1206105003507 putative PBP binding loops; other site 1206105003508 ABC-ATPase subunit interface; other site 1206105003509 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206105003510 dimer interface [polypeptide binding]; other site 1206105003511 conserved gate region; other site 1206105003512 ABC-ATPase subunit interface; other site 1206105003513 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1206105003514 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1206105003515 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1206105003516 homodimer interface [polypeptide binding]; other site 1206105003517 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1206105003518 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1206105003519 active site 1206105003520 homodimer interface [polypeptide binding]; other site 1206105003521 catalytic site [active] 1206105003522 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1206105003523 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1206105003524 Ca binding site [ion binding]; other site 1206105003525 active site 1206105003526 catalytic site [active] 1206105003527 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1206105003528 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1206105003529 Ca binding site [ion binding]; other site 1206105003530 active site 1206105003531 catalytic site [active] 1206105003532 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 1206105003533 magnesium-transporting ATPase; Provisional; Region: PRK15122 1206105003534 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1206105003535 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1206105003536 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1206105003537 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1206105003538 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1206105003539 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1206105003540 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1206105003541 tetramer interface [polypeptide binding]; other site 1206105003542 TPP-binding site [chemical binding]; other site 1206105003543 heterodimer interface [polypeptide binding]; other site 1206105003544 phosphorylation loop region [posttranslational modification] 1206105003545 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1206105003546 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1206105003547 alpha subunit interface [polypeptide binding]; other site 1206105003548 TPP binding site [chemical binding]; other site 1206105003549 heterodimer interface [polypeptide binding]; other site 1206105003550 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1206105003551 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 1206105003552 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1206105003553 E3 interaction surface; other site 1206105003554 lipoyl attachment site [posttranslational modification]; other site 1206105003555 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1206105003556 E3 interaction surface; other site 1206105003557 lipoyl attachment site [posttranslational modification]; other site 1206105003558 e3 binding domain; Region: E3_binding; pfam02817 1206105003559 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1206105003560 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1206105003561 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1206105003562 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1206105003563 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1206105003564 Sensory domain found in PocR; Region: PocR; pfam10114 1206105003565 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 1206105003566 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1206105003567 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1206105003568 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1206105003569 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1206105003570 dimer interface [polypeptide binding]; other site 1206105003571 active site 1206105003572 metal binding site [ion binding]; metal-binding site 1206105003573 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 1206105003574 dihydroxyacetone kinase, DhaK subunit; Region: dhaK1; TIGR02363 1206105003575 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1206105003576 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 1206105003577 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1206105003578 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 1206105003579 dimer interface [polypeptide binding]; other site 1206105003580 active site 1206105003581 putative acyltransferase; Provisional; Region: PRK05790 1206105003582 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1206105003583 dimer interface [polypeptide binding]; other site 1206105003584 active site 1206105003585 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 1206105003586 homodimer interface [polypeptide binding]; other site 1206105003587 catalytic residues [active] 1206105003588 NAD binding site [chemical binding]; other site 1206105003589 substrate binding pocket [chemical binding]; other site 1206105003590 flexible flap; other site 1206105003591 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1206105003592 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1206105003593 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1206105003594 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1206105003595 putative active site [active] 1206105003596 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1206105003597 DNA-binding site [nucleotide binding]; DNA binding site 1206105003598 RNA-binding motif; other site 1206105003599 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1206105003600 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1206105003601 non-specific DNA binding site [nucleotide binding]; other site 1206105003602 salt bridge; other site 1206105003603 sequence-specific DNA binding site [nucleotide binding]; other site 1206105003604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206105003605 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1206105003606 putative substrate translocation pore; other site 1206105003607 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206105003608 putative substrate translocation pore; other site 1206105003609 metal-dependent hydrolase; Provisional; Region: PRK00685 1206105003610 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1206105003611 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1206105003612 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1206105003613 DNA-binding site [nucleotide binding]; DNA binding site 1206105003614 DRTGG domain; Region: DRTGG; pfam07085 1206105003615 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1206105003616 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1206105003617 active site 2 [active] 1206105003618 active site 1 [active] 1206105003619 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1206105003620 DHH family; Region: DHH; pfam01368 1206105003621 DHHA1 domain; Region: DHHA1; pfam02272 1206105003622 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1206105003623 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1206105003624 PhnA protein; Region: PhnA; pfam03831 1206105003625 VanZ like family; Region: VanZ; cl01971 1206105003626 RDD family; Region: RDD; pfam06271 1206105003627 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1206105003628 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1206105003629 ATP binding site [chemical binding]; other site 1206105003630 Mg++ binding site [ion binding]; other site 1206105003631 motif III; other site 1206105003632 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1206105003633 nucleotide binding region [chemical binding]; other site 1206105003634 ATP-binding site [chemical binding]; other site 1206105003635 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1206105003636 DNA binding site [nucleotide binding] 1206105003637 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1206105003638 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1206105003639 motif 1; other site 1206105003640 active site 1206105003641 motif 2; other site 1206105003642 motif 3; other site 1206105003643 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1206105003644 DHHA1 domain; Region: DHHA1; pfam02272 1206105003645 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1206105003646 Family of unknown function (DUF633); Region: DUF633; pfam04816 1206105003647 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1206105003648 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1206105003649 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1206105003650 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1206105003651 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1206105003652 peptidase T; Region: peptidase-T; TIGR01882 1206105003653 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1206105003654 metal binding site [ion binding]; metal-binding site 1206105003655 dimer interface [polypeptide binding]; other site 1206105003656 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 1206105003657 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1206105003658 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1206105003659 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1206105003660 GTP binding site; other site 1206105003661 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1206105003662 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 1206105003663 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1206105003664 putative dimer interface [polypeptide binding]; other site 1206105003665 [2Fe-2S] cluster binding site [ion binding]; other site 1206105003666 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1206105003667 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1206105003668 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1206105003669 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1206105003670 catalytic loop [active] 1206105003671 iron binding site [ion binding]; other site 1206105003672 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1206105003673 4Fe-4S binding domain; Region: Fer4; pfam00037 1206105003674 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1206105003675 [4Fe-4S] binding site [ion binding]; other site 1206105003676 molybdopterin cofactor binding site; other site 1206105003677 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 1206105003678 molybdopterin cofactor binding site; other site 1206105003679 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1206105003680 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1206105003681 dimer interface [polypeptide binding]; other site 1206105003682 putative functional site; other site 1206105003683 putative MPT binding site; other site 1206105003684 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1206105003685 trimer interface [polypeptide binding]; other site 1206105003686 dimer interface [polypeptide binding]; other site 1206105003687 putative active site [active] 1206105003688 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 1206105003689 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1206105003690 FeS/SAM binding site; other site 1206105003691 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1206105003692 MOSC domain; Region: MOSC; pfam03473 1206105003693 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1206105003694 MPT binding site; other site 1206105003695 trimer interface [polypeptide binding]; other site 1206105003696 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 1206105003697 putative MPT binding site; other site 1206105003698 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1206105003699 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1206105003700 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1206105003701 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206105003702 putative PBP binding loops; other site 1206105003703 ABC-ATPase subunit interface; other site 1206105003704 ATP-binding cassette domain of the molybdenum transport system; Region: ABC_ModC_molybdenum_transporter; cd03297 1206105003705 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1206105003706 Walker A/P-loop; other site 1206105003707 ATP binding site [chemical binding]; other site 1206105003708 Q-loop/lid; other site 1206105003709 ABC transporter signature motif; other site 1206105003710 Walker B; other site 1206105003711 D-loop; other site 1206105003712 H-loop/switch region; other site 1206105003713 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1206105003714 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1206105003715 metal-binding site [ion binding] 1206105003716 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1206105003717 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1206105003718 Cell division protein ZapA; Region: ZapA; cl01146 1206105003719 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1206105003720 Colicin V production protein; Region: Colicin_V; pfam02674 1206105003721 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1206105003722 MutS domain III; Region: MutS_III; pfam05192 1206105003723 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206105003724 Walker A/P-loop; other site 1206105003725 ATP binding site [chemical binding]; other site 1206105003726 Q-loop/lid; other site 1206105003727 ABC transporter signature motif; other site 1206105003728 Walker B; other site 1206105003729 D-loop; other site 1206105003730 H-loop/switch region; other site 1206105003731 Smr domain; Region: Smr; pfam01713 1206105003732 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1206105003733 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1206105003734 catalytic residues [active] 1206105003735 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1206105003736 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1206105003737 GIY-YIG motif/motif A; other site 1206105003738 active site 1206105003739 catalytic site [active] 1206105003740 putative DNA binding site [nucleotide binding]; other site 1206105003741 metal binding site [ion binding]; metal-binding site 1206105003742 UvrB/uvrC motif; Region: UVR; pfam02151 1206105003743 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1206105003744 Protein of unknown function (DUF3884); Region: DUF3884; pfam13024 1206105003745 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1206105003746 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206105003747 Walker A/P-loop; other site 1206105003748 ATP binding site [chemical binding]; other site 1206105003749 Q-loop/lid; other site 1206105003750 ABC transporter signature motif; other site 1206105003751 Walker B; other site 1206105003752 D-loop; other site 1206105003753 H-loop/switch region; other site 1206105003754 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1206105003755 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1206105003756 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1206105003757 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1206105003758 DNA binding site [nucleotide binding] 1206105003759 domain linker motif; other site 1206105003760 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1206105003761 putative dimerization interface [polypeptide binding]; other site 1206105003762 putative ligand binding site [chemical binding]; other site 1206105003763 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1206105003764 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1206105003765 NAD binding site [chemical binding]; other site 1206105003766 sugar binding site [chemical binding]; other site 1206105003767 divalent metal binding site [ion binding]; other site 1206105003768 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1206105003769 dimer interface [polypeptide binding]; other site 1206105003770 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1206105003771 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1206105003772 ABC transporter; Region: ABC_tran_2; pfam12848 1206105003773 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1206105003774 HI0933-like protein; Region: HI0933_like; pfam03486 1206105003775 glutamate dehydrogenase; Provisional; Region: PRK09414 1206105003776 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1206105003777 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1206105003778 NAD(P) binding site [chemical binding]; other site 1206105003779 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1206105003780 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1206105003781 active site 1206105003782 dimer interface [polypeptide binding]; other site 1206105003783 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1206105003784 dimer interface [polypeptide binding]; other site 1206105003785 active site 1206105003786 flavoprotein NrdI; Provisional; Region: PRK02551 1206105003787 V-type ATP synthase subunit I; Validated; Region: PRK05771 1206105003788 V-type ATP synthase subunit K; Validated; Region: PRK06558 1206105003789 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 1206105003790 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 1206105003791 phosphodiesterase; Provisional; Region: PRK12704 1206105003792 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 1206105003793 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 1206105003794 V-type ATP synthase subunit F; Provisional; Region: PRK01395 1206105003795 V-type ATP synthase subunit A; Provisional; Region: PRK04192 1206105003796 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1206105003797 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 1206105003798 Walker A motif/ATP binding site; other site 1206105003799 Walker B motif; other site 1206105003800 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1206105003801 V-type ATP synthase subunit B; Provisional; Region: PRK04196 1206105003802 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1206105003803 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 1206105003804 Walker A motif homologous position; other site 1206105003805 Walker B motif; other site 1206105003806 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1206105003807 V-type ATP synthase subunit D; Reviewed; Region: PRK00373 1206105003808 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1206105003809 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1206105003810 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1206105003811 DNA binding residues [nucleotide binding] 1206105003812 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1206105003813 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 1206105003814 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1206105003815 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1206105003816 active site 1206105003817 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1206105003818 substrate binding site [chemical binding]; other site 1206105003819 catalytic residues [active] 1206105003820 dimer interface [polypeptide binding]; other site 1206105003821 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1206105003822 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1206105003823 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1206105003824 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1206105003825 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1206105003826 active site 1206105003827 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1206105003828 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1206105003829 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1206105003830 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1206105003831 peptide binding site [polypeptide binding]; other site 1206105003832 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1206105003833 CAT RNA binding domain; Region: CAT_RBD; smart01061 1206105003834 PRD domain; Region: PRD; pfam00874 1206105003835 PRD domain; Region: PRD; pfam00874 1206105003836 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1206105003837 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1206105003838 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1206105003839 active site turn [active] 1206105003840 phosphorylation site [posttranslational modification] 1206105003841 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1206105003842 HPr interaction site; other site 1206105003843 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1206105003844 active site 1206105003845 phosphorylation site [posttranslational modification] 1206105003846 HTH domain; Region: HTH_11; cl17392 1206105003847 PRD domain; Region: PRD; pfam00874 1206105003848 PRD domain; Region: PRD; pfam00874 1206105003849 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1206105003850 active site 1206105003851 P-loop; other site 1206105003852 phosphorylation site [posttranslational modification] 1206105003853 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 1206105003854 active site 1206105003855 phosphorylation site [posttranslational modification] 1206105003856 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1206105003857 active site 1206105003858 P-loop; other site 1206105003859 phosphorylation site [posttranslational modification] 1206105003860 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1206105003861 active site 1206105003862 phosphorylation site [posttranslational modification] 1206105003863 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1206105003864 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1206105003865 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1206105003866 substrate binding site [chemical binding]; other site 1206105003867 hexamer interface [polypeptide binding]; other site 1206105003868 metal binding site [ion binding]; metal-binding site 1206105003869 Lysozyme-like; Region: Lysozyme_like; pfam13702 1206105003870 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1206105003871 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1206105003872 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1206105003873 motif II; other site 1206105003874 DNA primase, catalytic core; Region: dnaG; TIGR01391 1206105003875 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1206105003876 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1206105003877 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1206105003878 active site 1206105003879 metal binding site [ion binding]; metal-binding site 1206105003880 interdomain interaction site; other site 1206105003881 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1206105003882 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1206105003883 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1206105003884 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1206105003885 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1206105003886 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1206105003887 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1206105003888 DNA binding residues [nucleotide binding] 1206105003889 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1206105003890 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1206105003891 S1 domain; Region: S1_2; pfam13509 1206105003892 ferric uptake regulator; Provisional; Region: fur; PRK09462 1206105003893 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1206105003894 metal binding site 2 [ion binding]; metal-binding site 1206105003895 putative DNA binding helix; other site 1206105003896 metal binding site 1 [ion binding]; metal-binding site 1206105003897 dimer interface [polypeptide binding]; other site 1206105003898 structural Zn2+ binding site [ion binding]; other site 1206105003899 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1206105003900 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1206105003901 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1206105003902 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1206105003903 GTP1/OBG; Region: GTP1_OBG; pfam01018 1206105003904 Obg GTPase; Region: Obg; cd01898 1206105003905 G1 box; other site 1206105003906 GTP/Mg2+ binding site [chemical binding]; other site 1206105003907 Switch I region; other site 1206105003908 G2 box; other site 1206105003909 G3 box; other site 1206105003910 Switch II region; other site 1206105003911 G4 box; other site 1206105003912 G5 box; other site 1206105003913 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1206105003914 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1206105003915 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1206105003916 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206105003917 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206105003918 WHG domain; Region: WHG; pfam13305 1206105003919 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 1206105003920 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 1206105003921 active site 1206105003922 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1206105003923 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1206105003924 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1206105003925 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1206105003926 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1206105003927 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1206105003928 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1206105003929 active site 1206105003930 Int/Topo IB signature motif; other site 1206105003931 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1206105003932 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1206105003933 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1206105003934 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1206105003935 RNA binding surface [nucleotide binding]; other site 1206105003936 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1206105003937 active site 1206105003938 Predicted membrane protein [Function unknown]; Region: COG3601 1206105003939 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1206105003940 Predicted membrane protein [Function unknown]; Region: COG4640 1206105003941 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1206105003942 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1206105003943 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1206105003944 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1206105003945 ATP binding site [chemical binding]; other site 1206105003946 putative Mg++ binding site [ion binding]; other site 1206105003947 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1206105003948 nucleotide binding region [chemical binding]; other site 1206105003949 ATP-binding site [chemical binding]; other site 1206105003950 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1206105003951 cytidylate kinase; Provisional; Region: cmk; PRK00023 1206105003952 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1206105003953 CMP-binding site; other site 1206105003954 The sites determining sugar specificity; other site 1206105003955 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1206105003956 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1206105003957 RNA binding site [nucleotide binding]; other site 1206105003958 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1206105003959 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1206105003960 RNA binding site [nucleotide binding]; other site 1206105003961 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1206105003962 RNA binding site [nucleotide binding]; other site 1206105003963 GTP-binding protein Der; Reviewed; Region: PRK00093 1206105003964 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1206105003965 G1 box; other site 1206105003966 GTP/Mg2+ binding site [chemical binding]; other site 1206105003967 Switch I region; other site 1206105003968 G2 box; other site 1206105003969 Switch II region; other site 1206105003970 G3 box; other site 1206105003971 G4 box; other site 1206105003972 G5 box; other site 1206105003973 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1206105003974 G1 box; other site 1206105003975 GTP/Mg2+ binding site [chemical binding]; other site 1206105003976 Switch I region; other site 1206105003977 G2 box; other site 1206105003978 G3 box; other site 1206105003979 Switch II region; other site 1206105003980 G4 box; other site 1206105003981 G5 box; other site 1206105003982 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1206105003983 IHF dimer interface [polypeptide binding]; other site 1206105003984 IHF - DNA interface [nucleotide binding]; other site 1206105003985 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1206105003986 TPR motif; other site 1206105003987 binding surface 1206105003988 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1206105003989 binding surface 1206105003990 TPR motif; other site 1206105003991 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1206105003992 TPR motif; other site 1206105003993 binding surface 1206105003994 hypothetical protein; Provisional; Region: PRK03636 1206105003995 UPF0302 domain; Region: UPF0302; pfam08864 1206105003996 A short protein domain of unknown function; Region: IDEAL; smart00914 1206105003997 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1206105003998 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1206105003999 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1206105004000 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 1206105004001 homodimer interface [polypeptide binding]; other site 1206105004002 metal binding site [ion binding]; metal-binding site 1206105004003 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1206105004004 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1206105004005 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1206105004006 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1206105004007 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1206105004008 active site 1206105004009 NTP binding site [chemical binding]; other site 1206105004010 metal binding triad [ion binding]; metal-binding site 1206105004011 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1206105004012 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1206105004013 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 1206105004014 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1206105004015 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1206105004016 shikimate binding site; other site 1206105004017 NAD(P) binding site [chemical binding]; other site 1206105004018 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 1206105004019 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1206105004020 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1206105004021 active site 1206105004022 dimer interface [polypeptide binding]; other site 1206105004023 metal binding site [ion binding]; metal-binding site 1206105004024 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1206105004025 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1206105004026 Tetramer interface [polypeptide binding]; other site 1206105004027 active site 1206105004028 FMN-binding site [chemical binding]; other site 1206105004029 prephenate dehydrogenase; Validated; Region: PRK06545 1206105004030 prephenate dehydrogenase; Validated; Region: PRK08507 1206105004031 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1206105004032 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1206105004033 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1206105004034 hinge; other site 1206105004035 active site 1206105004036 shikimate kinase; Reviewed; Region: aroK; PRK00131 1206105004037 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1206105004038 ADP binding site [chemical binding]; other site 1206105004039 magnesium binding site [ion binding]; other site 1206105004040 putative shikimate binding site; other site 1206105004041 prephenate dehydratase; Provisional; Region: PRK11898 1206105004042 Prephenate dehydratase; Region: PDT; pfam00800 1206105004043 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1206105004044 putative L-Phe binding site [chemical binding]; other site 1206105004045 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 1206105004046 EDD domain protein, DegV family; Region: DegV; TIGR00762 1206105004047 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1206105004048 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1206105004049 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1206105004050 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206105004051 Walker A/P-loop; other site 1206105004052 ATP binding site [chemical binding]; other site 1206105004053 Q-loop/lid; other site 1206105004054 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1206105004055 ABC transporter signature motif; other site 1206105004056 Walker B; other site 1206105004057 D-loop; other site 1206105004058 ABC transporter; Region: ABC_tran_2; pfam12848 1206105004059 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1206105004060 thymidylate synthase; Region: thym_sym; TIGR03284 1206105004061 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1206105004062 dimerization interface [polypeptide binding]; other site 1206105004063 active site 1206105004064 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1206105004065 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1206105004066 folate binding site [chemical binding]; other site 1206105004067 NADP+ binding site [chemical binding]; other site 1206105004068 epoxyqueuosine reductase; Region: TIGR00276 1206105004069 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1206105004070 HEAT repeat; Region: HEAT; pfam02985 1206105004071 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1206105004072 putative DNA binding site [nucleotide binding]; other site 1206105004073 LexA repressor; Validated; Region: PRK00215 1206105004074 putative Zn2+ binding site [ion binding]; other site 1206105004075 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1206105004076 Catalytic site [active] 1206105004077 hypothetical protein; Provisional; Region: PRK02539 1206105004078 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1206105004079 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1206105004080 TPP-binding site [chemical binding]; other site 1206105004081 dimer interface [polypeptide binding]; other site 1206105004082 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1206105004083 PYR/PP interface [polypeptide binding]; other site 1206105004084 dimer interface [polypeptide binding]; other site 1206105004085 TPP binding site [chemical binding]; other site 1206105004086 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1206105004087 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206105004088 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1206105004089 putative substrate translocation pore; other site 1206105004090 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1206105004091 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1206105004092 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1206105004093 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1206105004094 dimer interface [polypeptide binding]; other site 1206105004095 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206105004096 catalytic residue [active] 1206105004097 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1206105004098 metal binding site 2 [ion binding]; metal-binding site 1206105004099 putative DNA binding helix; other site 1206105004100 metal binding site 1 [ion binding]; metal-binding site 1206105004101 dimer interface [polypeptide binding]; other site 1206105004102 structural Zn2+ binding site [ion binding]; other site 1206105004103 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1206105004104 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1206105004105 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1206105004106 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 1206105004107 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 1206105004108 nudix motif; other site 1206105004109 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1206105004110 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1206105004111 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1206105004112 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1206105004113 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1206105004114 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1206105004115 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1206105004116 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1206105004117 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206105004118 Walker A/P-loop; other site 1206105004119 ATP binding site [chemical binding]; other site 1206105004120 Q-loop/lid; other site 1206105004121 ABC transporter signature motif; other site 1206105004122 Walker B; other site 1206105004123 D-loop; other site 1206105004124 H-loop/switch region; other site 1206105004125 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1206105004126 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1206105004127 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1206105004128 Walker A/P-loop; other site 1206105004129 ATP binding site [chemical binding]; other site 1206105004130 Q-loop/lid; other site 1206105004131 ABC transporter signature motif; other site 1206105004132 Walker B; other site 1206105004133 D-loop; other site 1206105004134 H-loop/switch region; other site 1206105004135 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1206105004136 nudix motif; other site 1206105004137 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1206105004138 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1206105004139 tetramer interface [polypeptide binding]; other site 1206105004140 heme binding pocket [chemical binding]; other site 1206105004141 NADPH binding site [chemical binding]; other site 1206105004142 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1206105004143 DNA photolyase; Region: DNA_photolyase; pfam00875 1206105004144 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1206105004145 non-specific DNA binding site [nucleotide binding]; other site 1206105004146 salt bridge; other site 1206105004147 sequence-specific DNA binding site [nucleotide binding]; other site 1206105004148 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1206105004149 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1206105004150 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1206105004151 active site turn [active] 1206105004152 phosphorylation site [posttranslational modification] 1206105004153 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1206105004154 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 1206105004155 HPr interaction site; other site 1206105004156 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1206105004157 active site 1206105004158 phosphorylation site [posttranslational modification] 1206105004159 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1206105004160 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1206105004161 Ca binding site [ion binding]; other site 1206105004162 active site 1206105004163 catalytic site [active] 1206105004164 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1206105004165 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1206105004166 substrate binding [chemical binding]; other site 1206105004167 active site 1206105004168 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1206105004169 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1206105004170 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1206105004171 DNA binding site [nucleotide binding] 1206105004172 domain linker motif; other site 1206105004173 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 1206105004174 dimerization interface [polypeptide binding]; other site 1206105004175 ligand binding site [chemical binding]; other site 1206105004176 sodium binding site [ion binding]; other site 1206105004177 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1206105004178 beta-galactosidase; Region: BGL; TIGR03356 1206105004179 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1206105004180 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1206105004181 active site turn [active] 1206105004182 phosphorylation site [posttranslational modification] 1206105004183 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1206105004184 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 1206105004185 HPr interaction site; other site 1206105004186 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1206105004187 active site 1206105004188 phosphorylation site [posttranslational modification] 1206105004189 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1206105004190 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1206105004191 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1206105004192 putative active site [active] 1206105004193 catalytic site [active] 1206105004194 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1206105004195 putative active site [active] 1206105004196 catalytic site [active] 1206105004197 hypothetical protein; Provisional; Region: PRK04164 1206105004198 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1206105004199 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 1206105004200 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1206105004201 DHH family; Region: DHH; pfam01368 1206105004202 DHHA2 domain; Region: DHHA2; pfam02833 1206105004203 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1206105004204 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1206105004205 FeS/SAM binding site; other site 1206105004206 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1206105004207 Pyruvate formate lyase 1; Region: PFL1; cd01678 1206105004208 coenzyme A binding site [chemical binding]; other site 1206105004209 active site 1206105004210 catalytic residues [active] 1206105004211 glycine loop; other site 1206105004212 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1206105004213 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1206105004214 CAP-like domain; other site 1206105004215 active site 1206105004216 primary dimer interface [polypeptide binding]; other site 1206105004217 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1206105004218 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1206105004219 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1206105004220 ATP binding site [chemical binding]; other site 1206105004221 Mg2+ binding site [ion binding]; other site 1206105004222 G-X-G motif; other site 1206105004223 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1206105004224 anchoring element; other site 1206105004225 dimer interface [polypeptide binding]; other site 1206105004226 ATP binding site [chemical binding]; other site 1206105004227 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1206105004228 active site 1206105004229 putative metal-binding site [ion binding]; other site 1206105004230 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1206105004231 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1206105004232 Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249 1206105004233 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 1206105004234 ethanolamine utilization protein EutH; Provisional; Region: PRK15086 1206105004235 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 1206105004236 Hexamer/Pentamer interface [polypeptide binding]; other site 1206105004237 central pore; other site 1206105004238 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 1206105004239 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 1206105004240 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1206105004241 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1206105004242 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 1206105004243 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1206105004244 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 1206105004245 Hexamer interface [polypeptide binding]; other site 1206105004246 Putative hexagonal pore residue; other site 1206105004247 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1206105004248 putative catalytic cysteine [active] 1206105004249 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1206105004250 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1206105004251 Hexamer interface [polypeptide binding]; other site 1206105004252 Hexagonal pore residue; other site 1206105004253 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 1206105004254 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 1206105004255 putative hexamer interface [polypeptide binding]; other site 1206105004256 putative hexagonal pore; other site 1206105004257 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 1206105004258 putative hexamer interface [polypeptide binding]; other site 1206105004259 putative hexagonal pore; other site 1206105004260 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 1206105004261 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 1206105004262 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1206105004263 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 1206105004264 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1206105004265 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1206105004266 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1206105004267 Histidine kinase; Region: HisKA_2; pfam07568 1206105004268 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1206105004269 ATP binding site [chemical binding]; other site 1206105004270 Mg2+ binding site [ion binding]; other site 1206105004271 G-X-G motif; other site 1206105004272 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1206105004273 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1206105004274 active site 1206105004275 phosphorylation site [posttranslational modification] 1206105004276 intermolecular recognition site; other site 1206105004277 dimerization interface [polypeptide binding]; other site 1206105004278 ANTAR domain; Region: ANTAR; pfam03861 1206105004279 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 1206105004280 putative hexamer interface [polypeptide binding]; other site 1206105004281 putative hexagonal pore; other site 1206105004282 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1206105004283 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 1206105004284 putative active site [active] 1206105004285 metal binding site [ion binding]; metal-binding site 1206105004286 ATP:cob(I)alamin adenosyltransferase; Region: PduO_Nterm; TIGR00636 1206105004287 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1206105004288 G1 box; other site 1206105004289 GTP/Mg2+ binding site [chemical binding]; other site 1206105004290 G2 box; other site 1206105004291 Switch I region; other site 1206105004292 G3 box; other site 1206105004293 Switch II region; other site 1206105004294 G4 box; other site 1206105004295 G5 box; other site 1206105004296 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1206105004297 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1206105004298 Walker A/P-loop; other site 1206105004299 ATP binding site [chemical binding]; other site 1206105004300 Q-loop/lid; other site 1206105004301 ABC transporter signature motif; other site 1206105004302 Walker B; other site 1206105004303 D-loop; other site 1206105004304 H-loop/switch region; other site 1206105004305 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1206105004306 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1206105004307 ABC-ATPase subunit interface; other site 1206105004308 dimer interface [polypeptide binding]; other site 1206105004309 putative PBP binding regions; other site 1206105004310 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1206105004311 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1206105004312 putative binding site residues; other site 1206105004313 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 1206105004314 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 1206105004315 active site 1206105004316 catalytic residues [active] 1206105004317 CodY GAF-like domain; Region: CodY; pfam06018 1206105004318 GTP-sensing transcriptional pleiotropic repressor CodY; Region: codY_Gpos; TIGR02787 1206105004319 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1206105004320 putative DNA binding site [nucleotide binding]; other site 1206105004321 putative Zn2+ binding site [ion binding]; other site 1206105004322 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1206105004323 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1206105004324 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206105004325 Walker A motif; other site 1206105004326 ATP binding site [chemical binding]; other site 1206105004327 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1206105004328 Walker B motif; other site 1206105004329 arginine finger; other site 1206105004330 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1206105004331 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1206105004332 active site 1206105004333 HslU subunit interaction site [polypeptide binding]; other site 1206105004334 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1206105004335 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1206105004336 active site 1206105004337 Int/Topo IB signature motif; other site 1206105004338 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1206105004339 Glucose inhibited division protein A; Region: GIDA; pfam01134 1206105004340 DNA topoisomerase I; Validated; Region: PRK05582 1206105004341 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1206105004342 active site 1206105004343 interdomain interaction site; other site 1206105004344 putative metal-binding site [ion binding]; other site 1206105004345 nucleotide binding site [chemical binding]; other site 1206105004346 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1206105004347 domain I; other site 1206105004348 DNA binding groove [nucleotide binding] 1206105004349 phosphate binding site [ion binding]; other site 1206105004350 domain II; other site 1206105004351 domain III; other site 1206105004352 nucleotide binding site [chemical binding]; other site 1206105004353 catalytic site [active] 1206105004354 domain IV; other site 1206105004355 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1206105004356 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1206105004357 CAAX protease self-immunity; Region: Abi; pfam02517 1206105004358 DNA protecting protein DprA; Region: dprA; TIGR00732 1206105004359 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1206105004360 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1206105004361 RNA/DNA hybrid binding site [nucleotide binding]; other site 1206105004362 active site 1206105004363 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1206105004364 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1206105004365 GTP/Mg2+ binding site [chemical binding]; other site 1206105004366 G4 box; other site 1206105004367 G5 box; other site 1206105004368 G1 box; other site 1206105004369 Switch I region; other site 1206105004370 G2 box; other site 1206105004371 G3 box; other site 1206105004372 Switch II region; other site 1206105004373 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1206105004374 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1206105004375 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1206105004376 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1206105004377 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1206105004378 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1206105004379 dimerization interface [polypeptide binding]; other site 1206105004380 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1206105004381 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1206105004382 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1206105004383 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1206105004384 E3 interaction surface; other site 1206105004385 lipoyl attachment site [posttranslational modification]; other site 1206105004386 e3 binding domain; Region: E3_binding; pfam02817 1206105004387 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1206105004388 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1206105004389 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1206105004390 alpha subunit interface [polypeptide binding]; other site 1206105004391 TPP binding site [chemical binding]; other site 1206105004392 heterodimer interface [polypeptide binding]; other site 1206105004393 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1206105004394 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1206105004395 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1206105004396 tetramer interface [polypeptide binding]; other site 1206105004397 TPP-binding site [chemical binding]; other site 1206105004398 heterodimer interface [polypeptide binding]; other site 1206105004399 phosphorylation loop region [posttranslational modification] 1206105004400 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1206105004401 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1206105004402 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1206105004403 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1206105004404 nucleotide binding site [chemical binding]; other site 1206105004405 Acetokinase family; Region: Acetate_kinase; cl17229 1206105004406 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 1206105004407 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1206105004408 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1206105004409 putative active site [active] 1206105004410 TraX protein; Region: TraX; cl05434 1206105004411 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1206105004412 classical (c) SDRs; Region: SDR_c; cd05233 1206105004413 NAD(P) binding site [chemical binding]; other site 1206105004414 active site 1206105004415 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1206105004416 MarR family; Region: MarR; pfam01047 1206105004417 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1206105004418 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1206105004419 Zn binding site [ion binding]; other site 1206105004420 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1206105004421 Zn binding site [ion binding]; other site 1206105004422 Predicted esterase [General function prediction only]; Region: COG0400 1206105004423 putative hydrolase; Provisional; Region: PRK11460 1206105004424 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1206105004425 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1206105004426 putative NAD(P) binding site [chemical binding]; other site 1206105004427 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1206105004428 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1206105004429 FtsX-like permease family; Region: FtsX; pfam02687 1206105004430 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1206105004431 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1206105004432 Walker A/P-loop; other site 1206105004433 ATP binding site [chemical binding]; other site 1206105004434 Q-loop/lid; other site 1206105004435 ABC transporter signature motif; other site 1206105004436 Walker B; other site 1206105004437 D-loop; other site 1206105004438 H-loop/switch region; other site 1206105004439 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1206105004440 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1206105004441 Walker A/P-loop; other site 1206105004442 ATP binding site [chemical binding]; other site 1206105004443 Q-loop/lid; other site 1206105004444 ABC transporter signature motif; other site 1206105004445 Walker B; other site 1206105004446 D-loop; other site 1206105004447 H-loop/switch region; other site 1206105004448 Predicted transcriptional regulators [Transcription]; Region: COG1725 1206105004449 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1206105004450 DNA-binding site [nucleotide binding]; DNA binding site 1206105004451 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1206105004452 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 1206105004453 Catalytic site [active] 1206105004454 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1206105004455 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1206105004456 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1206105004457 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1206105004458 protein binding site [polypeptide binding]; other site 1206105004459 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1206105004460 Catalytic dyad [active] 1206105004461 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1206105004462 hypothetical protein; Provisional; Region: PRK13672 1206105004463 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1206105004464 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 1206105004465 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 1206105004466 active site 1206105004467 catalytic triad [active] 1206105004468 oxyanion hole [active] 1206105004469 EDD domain protein, DegV family; Region: DegV; TIGR00762 1206105004470 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1206105004471 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1206105004472 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1206105004473 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1206105004474 active site 1206105004475 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1206105004476 DHH family; Region: DHH; pfam01368 1206105004477 DHHA1 domain; Region: DHHA1; pfam02272 1206105004478 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 1206105004479 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1206105004480 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1206105004481 NAD(P) binding site [chemical binding]; other site 1206105004482 active site 1206105004483 ribonuclease Z; Region: RNase_Z; TIGR02651 1206105004484 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1206105004485 KH domain; Region: KH_4; pfam13083 1206105004486 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1206105004487 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1206105004488 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1206105004489 Coenzyme A binding pocket [chemical binding]; other site 1206105004490 Predicted flavoprotein [General function prediction only]; Region: COG0431 1206105004491 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1206105004492 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1206105004493 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1206105004494 DNA binding residues [nucleotide binding] 1206105004495 dimer interface [polypeptide binding]; other site 1206105004496 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1206105004497 signal recognition particle protein; Provisional; Region: PRK10867 1206105004498 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1206105004499 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1206105004500 P loop; other site 1206105004501 GTP binding site [chemical binding]; other site 1206105004502 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1206105004503 putative DNA-binding protein; Validated; Region: PRK00118 1206105004504 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1206105004505 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1206105004506 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1206105004507 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1206105004508 active site 1206105004509 phosphorylation site [posttranslational modification] 1206105004510 intermolecular recognition site; other site 1206105004511 dimerization interface [polypeptide binding]; other site 1206105004512 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1206105004513 DNA binding site [nucleotide binding] 1206105004514 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1206105004515 PAS domain; Region: PAS; smart00091 1206105004516 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1206105004517 dimer interface [polypeptide binding]; other site 1206105004518 phosphorylation site [posttranslational modification] 1206105004519 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1206105004520 ATP binding site [chemical binding]; other site 1206105004521 Mg2+ binding site [ion binding]; other site 1206105004522 G-X-G motif; other site 1206105004523 PBP superfamily domain; Region: PBP_like_2; cl17296 1206105004524 aromatic amino acid aminotransferase; Validated; Region: PRK07309 1206105004525 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1206105004526 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206105004527 homodimer interface [polypeptide binding]; other site 1206105004528 catalytic residue [active] 1206105004529 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 1206105004530 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 1206105004531 active site 1206105004532 metal binding site [ion binding]; metal-binding site 1206105004533 homodimer interface [polypeptide binding]; other site 1206105004534 catalytic site [active] 1206105004535 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1206105004536 Uncharacterized conserved protein [Function unknown]; Region: COG3538 1206105004537 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 1206105004538 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1206105004539 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1206105004540 DNA-binding site [nucleotide binding]; DNA binding site 1206105004541 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1206105004542 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1206105004543 ligand binding site [chemical binding]; other site 1206105004544 dimerization interface [polypeptide binding]; other site 1206105004545 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1206105004546 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1206105004547 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1206105004548 dimerization interface [polypeptide binding]; other site 1206105004549 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 1206105004550 active site 1206105004551 zinc binding site [ion binding]; other site 1206105004552 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1206105004553 active site 1206105004554 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1206105004555 active site 1206105004556 dimer interface [polypeptide binding]; other site 1206105004557 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1206105004558 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1206105004559 heterodimer interface [polypeptide binding]; other site 1206105004560 active site 1206105004561 FMN binding site [chemical binding]; other site 1206105004562 homodimer interface [polypeptide binding]; other site 1206105004563 substrate binding site [chemical binding]; other site 1206105004564 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1206105004565 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1206105004566 FAD binding pocket [chemical binding]; other site 1206105004567 FAD binding motif [chemical binding]; other site 1206105004568 phosphate binding motif [ion binding]; other site 1206105004569 beta-alpha-beta structure motif; other site 1206105004570 NAD binding pocket [chemical binding]; other site 1206105004571 Iron coordination center [ion binding]; other site 1206105004572 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1206105004573 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1206105004574 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1206105004575 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1206105004576 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1206105004577 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1206105004578 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1206105004579 IMP binding site; other site 1206105004580 dimer interface [polypeptide binding]; other site 1206105004581 interdomain contacts; other site 1206105004582 partial ornithine binding site; other site 1206105004583 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1206105004584 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1206105004585 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1206105004586 catalytic site [active] 1206105004587 subunit interface [polypeptide binding]; other site 1206105004588 dihydroorotase; Validated; Region: pyrC; PRK09357 1206105004589 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1206105004590 active site 1206105004591 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1206105004592 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1206105004593 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1206105004594 uracil transporter; Provisional; Region: PRK10720 1206105004595 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1206105004596 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1206105004597 active site 1206105004598 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1206105004599 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1206105004600 RNA binding surface [nucleotide binding]; other site 1206105004601 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1206105004602 active site 1206105004603 lipoprotein signal peptidase; Provisional; Region: PRK14797 1206105004604 lipoprotein signal peptidase; Provisional; Region: PRK14787 1206105004605 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1206105004606 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1206105004607 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1206105004608 Potassium binding sites [ion binding]; other site 1206105004609 Cesium cation binding sites [ion binding]; other site 1206105004610 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1206105004611 DNA-binding site [nucleotide binding]; DNA binding site 1206105004612 RNA-binding motif; other site 1206105004613 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1206105004614 RNA/DNA hybrid binding site [nucleotide binding]; other site 1206105004615 active site 1206105004616 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1206105004617 putative deacylase active site [active] 1206105004618 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1206105004619 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1206105004620 active site 1206105004621 catalytic residue [active] 1206105004622 dimer interface [polypeptide binding]; other site 1206105004623 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1206105004624 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1206105004625 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1206105004626 Walker A/P-loop; other site 1206105004627 ATP binding site [chemical binding]; other site 1206105004628 Q-loop/lid; other site 1206105004629 ABC transporter signature motif; other site 1206105004630 Walker B; other site 1206105004631 D-loop; other site 1206105004632 H-loop/switch region; other site 1206105004633 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1206105004634 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1206105004635 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206105004636 Walker A/P-loop; other site 1206105004637 ATP binding site [chemical binding]; other site 1206105004638 Q-loop/lid; other site 1206105004639 ABC transporter signature motif; other site 1206105004640 Walker B; other site 1206105004641 D-loop; other site 1206105004642 H-loop/switch region; other site 1206105004643 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 1206105004644 endonuclease IV; Provisional; Region: PRK01060 1206105004645 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1206105004646 AP (apurinic/apyrimidinic) site pocket; other site 1206105004647 DNA interaction; other site 1206105004648 Metal-binding active site; metal-binding site 1206105004649 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1206105004650 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1206105004651 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1206105004652 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1206105004653 active site 1206105004654 HIGH motif; other site 1206105004655 dimer interface [polypeptide binding]; other site 1206105004656 KMSKS motif; other site 1206105004657 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1206105004658 RNA binding surface [nucleotide binding]; other site 1206105004659 Transglycosylase; Region: Transgly; pfam00912 1206105004660 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1206105004661 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1206105004662 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1206105004663 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1206105004664 Walker A/P-loop; other site 1206105004665 ATP binding site [chemical binding]; other site 1206105004666 Q-loop/lid; other site 1206105004667 ABC transporter signature motif; other site 1206105004668 Walker B; other site 1206105004669 D-loop; other site 1206105004670 H-loop/switch region; other site 1206105004671 catabolite control protein A; Region: ccpA; TIGR01481 1206105004672 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1206105004673 DNA binding site [nucleotide binding] 1206105004674 domain linker motif; other site 1206105004675 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1206105004676 dimerization interface [polypeptide binding]; other site 1206105004677 effector binding site; other site 1206105004678 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1206105004679 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1206105004680 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1206105004681 active site 1206105004682 YtxH-like protein; Region: YtxH; pfam12732 1206105004683 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 1206105004684 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1206105004685 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1206105004686 active site 1206105004687 tetramer interface; other site 1206105004688 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1206105004689 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1206105004690 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1206105004691 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1206105004692 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1206105004693 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1206105004694 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1206105004695 Hpr binding site; other site 1206105004696 active site 1206105004697 homohexamer subunit interaction site [polypeptide binding]; other site 1206105004698 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1206105004699 GIY-YIG motif/motif A; other site 1206105004700 active site 1206105004701 catalytic site [active] 1206105004702 putative DNA binding site [nucleotide binding]; other site 1206105004703 metal binding site [ion binding]; metal-binding site 1206105004704 Membrane protein of unknown function; Region: DUF360; pfam04020 1206105004705 PspC domain; Region: PspC; pfam04024 1206105004706 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1206105004707 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1206105004708 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1206105004709 PhoU domain; Region: PhoU; pfam01895 1206105004710 PhoU domain; Region: PhoU; pfam01895 1206105004711 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14255 1206105004712 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1206105004713 Walker A/P-loop; other site 1206105004714 ATP binding site [chemical binding]; other site 1206105004715 Q-loop/lid; other site 1206105004716 ABC transporter signature motif; other site 1206105004717 Walker B; other site 1206105004718 D-loop; other site 1206105004719 H-loop/switch region; other site 1206105004720 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 1206105004721 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1206105004722 Walker A/P-loop; other site 1206105004723 ATP binding site [chemical binding]; other site 1206105004724 Q-loop/lid; other site 1206105004725 ABC transporter signature motif; other site 1206105004726 Walker B; other site 1206105004727 D-loop; other site 1206105004728 H-loop/switch region; other site 1206105004729 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1206105004730 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206105004731 dimer interface [polypeptide binding]; other site 1206105004732 conserved gate region; other site 1206105004733 putative PBP binding loops; other site 1206105004734 ABC-ATPase subunit interface; other site 1206105004735 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1206105004736 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206105004737 dimer interface [polypeptide binding]; other site 1206105004738 conserved gate region; other site 1206105004739 putative PBP binding loops; other site 1206105004740 ABC-ATPase subunit interface; other site 1206105004741 phosphate binding protein; Region: ptsS_2; TIGR02136 1206105004742 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1206105004743 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1206105004744 FtsX-like permease family; Region: FtsX; pfam02687 1206105004745 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1206105004746 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206105004747 Walker A/P-loop; other site 1206105004748 ATP binding site [chemical binding]; other site 1206105004749 Q-loop/lid; other site 1206105004750 ABC transporter signature motif; other site 1206105004751 Walker B; other site 1206105004752 D-loop; other site 1206105004753 H-loop/switch region; other site 1206105004754 peptide chain release factor 2; Provisional; Region: PRK06746 1206105004755 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1206105004756 RF-1 domain; Region: RF-1; pfam00472 1206105004757 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1206105004758 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1206105004759 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1206105004760 nucleotide binding region [chemical binding]; other site 1206105004761 ATP-binding site [chemical binding]; other site 1206105004762 SEC-C motif; Region: SEC-C; pfam02810 1206105004763 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1206105004764 30S subunit binding site; other site 1206105004765 comF family protein; Region: comF; TIGR00201 1206105004766 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1206105004767 active site 1206105004768 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1206105004769 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1206105004770 ATP binding site [chemical binding]; other site 1206105004771 putative Mg++ binding site [ion binding]; other site 1206105004772 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1206105004773 nucleotide binding region [chemical binding]; other site 1206105004774 ATP-binding site [chemical binding]; other site 1206105004775 Predicted ATPase [General function prediction only]; Region: COG3910 1206105004776 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206105004777 ATP-binding cassette domain of non-transporter proteins; Region: ABC_Class2; cd03227 1206105004778 Walker A/P-loop; other site 1206105004779 Walker A/P-loop; other site 1206105004780 ATP binding site [chemical binding]; other site 1206105004781 ATP binding site [chemical binding]; other site 1206105004782 Q-loop/lid; other site 1206105004783 ABC transporter signature motif; other site 1206105004784 Walker B; other site 1206105004785 D-loop; other site 1206105004786 H-loop/switch region; other site 1206105004787 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1206105004788 active site 1206105004789 P-loop; other site 1206105004790 phosphorylation site [posttranslational modification] 1206105004791 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1206105004792 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1206105004793 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1206105004794 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 1206105004795 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 1206105004796 classical (c) SDRs; Region: SDR_c; cd05233 1206105004797 NAD(P) binding site [chemical binding]; other site 1206105004798 active site 1206105004799 QueT transporter; Region: QueT; pfam06177 1206105004800 Tim44-like domain; Region: Tim44; cl09208 1206105004801 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1206105004802 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1206105004803 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1206105004804 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1206105004805 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1206105004806 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1206105004807 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1206105004808 purine monophosphate binding site [chemical binding]; other site 1206105004809 dimer interface [polypeptide binding]; other site 1206105004810 putative catalytic residues [active] 1206105004811 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1206105004812 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1206105004813 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1206105004814 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1206105004815 active site 1206105004816 substrate binding site [chemical binding]; other site 1206105004817 cosubstrate binding site; other site 1206105004818 catalytic site [active] 1206105004819 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1206105004820 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1206105004821 dimerization interface [polypeptide binding]; other site 1206105004822 putative ATP binding site [chemical binding]; other site 1206105004823 amidophosphoribosyltransferase; Provisional; Region: PRK07272 1206105004824 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1206105004825 active site 1206105004826 tetramer interface [polypeptide binding]; other site 1206105004827 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1206105004828 active site 1206105004829 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1206105004830 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1206105004831 dimerization interface [polypeptide binding]; other site 1206105004832 ATP binding site [chemical binding]; other site 1206105004833 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1206105004834 dimerization interface [polypeptide binding]; other site 1206105004835 ATP binding site [chemical binding]; other site 1206105004836 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1206105004837 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1206105004838 putative active site [active] 1206105004839 catalytic triad [active] 1206105004840 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 1206105004841 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1206105004842 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1206105004843 ATP binding site [chemical binding]; other site 1206105004844 active site 1206105004845 substrate binding site [chemical binding]; other site 1206105004846 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1206105004847 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1206105004848 NAD binding site [chemical binding]; other site 1206105004849 ATP-grasp domain; Region: ATP-grasp; pfam02222 1206105004850 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1206105004851 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1206105004852 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 1206105004853 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1206105004854 putative substrate binding site [chemical binding]; other site 1206105004855 putative ATP binding site [chemical binding]; other site 1206105004856 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1206105004857 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1206105004858 peptide binding site [polypeptide binding]; other site 1206105004859 Cupin domain; Region: Cupin_2; pfam07883 1206105004860 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1206105004861 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1206105004862 homodimer interface [polypeptide binding]; other site 1206105004863 substrate-cofactor binding pocket; other site 1206105004864 catalytic residue [active] 1206105004865 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 1206105004866 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1206105004867 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1206105004868 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1206105004869 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 1206105004870 Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905 1206105004871 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1206105004872 active pocket/dimerization site; other site 1206105004873 active site 1206105004874 phosphorylation site [posttranslational modification] 1206105004875 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 1206105004876 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 1206105004877 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1206105004878 active site 1206105004879 phosphorylation site [posttranslational modification] 1206105004880 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1206105004881 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 1206105004882 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1206105004883 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 1206105004884 putative substrate binding site [chemical binding]; other site 1206105004885 putative ATP binding site [chemical binding]; other site 1206105004886 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 1206105004887 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 1206105004888 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1206105004889 dimer interface [polypeptide binding]; other site 1206105004890 active site 1206105004891 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 1206105004892 putative active site [active] 1206105004893 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1206105004894 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1206105004895 DNA-binding site [nucleotide binding]; DNA binding site 1206105004896 UTRA domain; Region: UTRA; pfam07702 1206105004897 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1206105004898 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1206105004899 Ligand binding site; other site 1206105004900 metal-binding site 1206105004901 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1206105004902 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1206105004903 Ligand binding site; other site 1206105004904 metal-binding site 1206105004905 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1206105004906 Sulfatase; Region: Sulfatase; pfam00884 1206105004907 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206105004908 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1206105004909 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206105004910 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1206105004911 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1206105004912 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1206105004913 putative hydrolase; Provisional; Region: PRK02113 1206105004914 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1206105004915 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1206105004916 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1206105004917 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1206105004918 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1206105004919 active site 1206105004920 Zn binding site [ion binding]; other site 1206105004921 Accessory gene regulator B; Region: AgrB; smart00793 1206105004922 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1206105004923 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1206105004924 active site 1206105004925 phosphorylation site [posttranslational modification] 1206105004926 intermolecular recognition site; other site 1206105004927 dimerization interface [polypeptide binding]; other site 1206105004928 LytTr DNA-binding domain; Region: LytTR; pfam04397 1206105004929 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 1206105004930 CHAP domain; Region: CHAP; pfam05257 1206105004931 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 1206105004932 putative active site [active] 1206105004933 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1206105004934 Peptidase family M23; Region: Peptidase_M23; pfam01551 1206105004935 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 1206105004936 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1206105004937 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1206105004938 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1206105004939 RimM N-terminal domain; Region: RimM; pfam01782 1206105004940 PRC-barrel domain; Region: PRC; pfam05239 1206105004941 manganese transport protein MntH; Reviewed; Region: PRK00701 1206105004942 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1206105004943 Mitomycin C resistance protein (MRD); Region: MRD; cd07235 1206105004944 dimer interface [polypeptide binding]; other site 1206105004945 ligand binding site [chemical binding]; other site 1206105004946 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1206105004947 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1206105004948 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1206105004949 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 1206105004950 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1206105004951 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 1206105004952 putative active site [active] 1206105004953 catalytic site [active] 1206105004954 putative metal binding site [ion binding]; other site 1206105004955 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1206105004956 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1206105004957 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 1206105004958 dimer interaction site [polypeptide binding]; other site 1206105004959 substrate-binding tunnel; other site 1206105004960 active site 1206105004961 catalytic site [active] 1206105004962 substrate binding site [chemical binding]; other site 1206105004963 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1206105004964 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1206105004965 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1206105004966 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1206105004967 Predicted membrane protein [Function unknown]; Region: COG4129 1206105004968 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1206105004969 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 1206105004970 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1206105004971 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1206105004972 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1206105004973 nucleotide binding site [chemical binding]; other site 1206105004974 Haemolytic domain; Region: Haemolytic; pfam01809 1206105004975 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1206105004976 G1 box; other site 1206105004977 GTP/Mg2+ binding site [chemical binding]; other site 1206105004978 Switch I region; other site 1206105004979 G2 box; other site 1206105004980 G3 box; other site 1206105004981 Switch II region; other site 1206105004982 G4 box; other site 1206105004983 G5 box; other site 1206105004984 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1206105004985 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1206105004986 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206105004987 Walker A motif; other site 1206105004988 ATP binding site [chemical binding]; other site 1206105004989 Walker B motif; other site 1206105004990 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1206105004991 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1206105004992 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1206105004993 Coenzyme A binding pocket [chemical binding]; other site 1206105004994 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 1206105004995 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1206105004996 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1206105004997 active site 1206105004998 tetramer interface [polypeptide binding]; other site 1206105004999 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1206105005000 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1206105005001 DNA binding site [nucleotide binding] 1206105005002 Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability; Region: PBP1_FucR_like; cd06276 1206105005003 putative dimerization interface [polypeptide binding]; other site 1206105005004 putative ligand binding site [chemical binding]; other site 1206105005005 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1206105005006 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1206105005007 substrate binding site [chemical binding]; other site 1206105005008 dimer interface [polypeptide binding]; other site 1206105005009 ATP binding site [chemical binding]; other site 1206105005010 Mga helix-turn-helix domain; Region: Mga; pfam05043 1206105005011 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 1206105005012 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1206105005013 amphipathic channel; other site 1206105005014 Asn-Pro-Ala signature motifs; other site 1206105005015 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1206105005016 glycerol kinase; Provisional; Region: glpK; PRK00047 1206105005017 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1206105005018 N- and C-terminal domain interface [polypeptide binding]; other site 1206105005019 active site 1206105005020 MgATP binding site [chemical binding]; other site 1206105005021 catalytic site [active] 1206105005022 metal binding site [ion binding]; metal-binding site 1206105005023 glycerol binding site [chemical binding]; other site 1206105005024 homotetramer interface [polypeptide binding]; other site 1206105005025 homodimer interface [polypeptide binding]; other site 1206105005026 FBP binding site [chemical binding]; other site 1206105005027 protein IIAGlc interface [polypeptide binding]; other site 1206105005028 Mga helix-turn-helix domain; Region: Mga; pfam05043 1206105005029 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 1206105005030 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1206105005031 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1206105005032 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1206105005033 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1206105005034 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1206105005035 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1206105005036 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1206105005037 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1206105005038 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1206105005039 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1206105005040 Predicted membrane protein [Function unknown]; Region: COG2364 1206105005041 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1206105005042 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 1206105005043 ligand binding site [chemical binding]; other site 1206105005044 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1206105005045 putative switch regulator; other site 1206105005046 non-specific DNA interactions [nucleotide binding]; other site 1206105005047 DNA binding site [nucleotide binding] 1206105005048 sequence specific DNA binding site [nucleotide binding]; other site 1206105005049 putative cAMP binding site [chemical binding]; other site 1206105005050 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 1206105005051 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1206105005052 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206105005053 putative substrate translocation pore; other site 1206105005054 Sulfatase; Region: Sulfatase; pfam00884 1206105005055 Domain of unknown function (DU1801); Region: DUF1801; cl17490 1206105005056 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 1206105005057 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1206105005058 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1206105005059 putative active site [active] 1206105005060 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1206105005061 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1206105005062 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1206105005063 dimer interface [polypeptide binding]; other site 1206105005064 active site 1206105005065 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1206105005066 dimer interface [polypeptide binding]; other site 1206105005067 active site 1206105005068 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 1206105005069 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 1206105005070 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1206105005071 active site 1206105005072 phosphorylation site [posttranslational modification] 1206105005073 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1206105005074 active pocket/dimerization site; other site 1206105005075 active site 1206105005076 phosphorylation site [posttranslational modification] 1206105005077 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1206105005078 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206105005079 Walker A motif; other site 1206105005080 ATP binding site [chemical binding]; other site 1206105005081 Walker B motif; other site 1206105005082 arginine finger; other site 1206105005083 Transcriptional antiterminator [Transcription]; Region: COG3933 1206105005084 PRD domain; Region: PRD; pfam00874 1206105005085 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1206105005086 active pocket/dimerization site; other site 1206105005087 active site 1206105005088 phosphorylation site [posttranslational modification] 1206105005089 PRD domain; Region: PRD; pfam00874 1206105005090 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 1206105005091 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1206105005092 Zn2+ binding site [ion binding]; other site 1206105005093 Mg2+ binding site [ion binding]; other site 1206105005094 TIR domain; Region: TIR_2; pfam13676 1206105005095 enolase; Provisional; Region: eno; PRK00077 1206105005096 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1206105005097 dimer interface [polypeptide binding]; other site 1206105005098 metal binding site [ion binding]; metal-binding site 1206105005099 substrate binding pocket [chemical binding]; other site 1206105005100 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1206105005101 triosephosphate isomerase; Provisional; Region: PRK14565 1206105005102 substrate binding site [chemical binding]; other site 1206105005103 dimer interface [polypeptide binding]; other site 1206105005104 catalytic triad [active] 1206105005105 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1206105005106 Phosphoglycerate kinase; Region: PGK; pfam00162 1206105005107 substrate binding site [chemical binding]; other site 1206105005108 hinge regions; other site 1206105005109 ADP binding site [chemical binding]; other site 1206105005110 catalytic site [active] 1206105005111 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1206105005112 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1206105005113 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1206105005114 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1206105005115 Predicted transcriptional regulator [Transcription]; Region: COG3388 1206105005116 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1206105005117 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1206105005118 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1206105005119 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1206105005120 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1206105005121 Protein of unknown function (DUF436); Region: DUF436; pfam04260 1206105005122 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 1206105005123 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1206105005124 dimer interface [polypeptide binding]; other site 1206105005125 substrate binding site [chemical binding]; other site 1206105005126 ATP binding site [chemical binding]; other site 1206105005127 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1206105005128 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1206105005129 dimer interface [polypeptide binding]; other site 1206105005130 anticodon binding site; other site 1206105005131 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1206105005132 homodimer interface [polypeptide binding]; other site 1206105005133 motif 1; other site 1206105005134 active site 1206105005135 motif 2; other site 1206105005136 GAD domain; Region: GAD; pfam02938 1206105005137 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1206105005138 motif 3; other site 1206105005139 histidyl-tRNA synthetase; Region: hisS; TIGR00442 1206105005140 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1206105005141 dimer interface [polypeptide binding]; other site 1206105005142 motif 1; other site 1206105005143 active site 1206105005144 motif 2; other site 1206105005145 motif 3; other site 1206105005146 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1206105005147 anticodon binding site; other site 1206105005148 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1206105005149 putative active site [active] 1206105005150 dimerization interface [polypeptide binding]; other site 1206105005151 putative tRNAtyr binding site [nucleotide binding]; other site 1206105005152 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1206105005153 HD domain; Region: HD_4; pfam13328 1206105005154 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1206105005155 synthetase active site [active] 1206105005156 NTP binding site [chemical binding]; other site 1206105005157 metal binding site [ion binding]; metal-binding site 1206105005158 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1206105005159 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1206105005160 RNA methyltransferase, RsmE family; Region: TIGR00046 1206105005161 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 1206105005162 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1206105005163 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206105005164 S-adenosylmethionine binding site [chemical binding]; other site 1206105005165 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 1206105005166 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1206105005167 active site 1206105005168 DNA binding site [nucleotide binding] 1206105005169 recombination factor protein RarA; Reviewed; Region: PRK13342 1206105005170 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206105005171 Walker A motif; other site 1206105005172 ATP binding site [chemical binding]; other site 1206105005173 Walker B motif; other site 1206105005174 arginine finger; other site 1206105005175 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1206105005176 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1206105005177 Ligand Binding Site [chemical binding]; other site 1206105005178 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1206105005179 propionate/acetate kinase; Provisional; Region: PRK12379 1206105005180 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1206105005181 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1206105005182 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 1206105005183 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1206105005184 Ferrochelatase; Region: Ferrochelatase; pfam00762 1206105005185 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1206105005186 C-terminal domain interface [polypeptide binding]; other site 1206105005187 active site 1206105005188 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1206105005189 active site 1206105005190 N-terminal domain interface [polypeptide binding]; other site 1206105005191 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1206105005192 Helix-turn-helix domain; Region: HTH_38; pfam13936 1206105005193 Integrase core domain; Region: rve; pfam00665 1206105005194 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1206105005195 DNA-binding site [nucleotide binding]; DNA binding site 1206105005196 RNA-binding motif; other site 1206105005197 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 1206105005198 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1206105005199 active site 1206105005200 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 1206105005201 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1206105005202 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1206105005203 Holin family; Region: Phage_holin_4; cl01989 1206105005204 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 1206105005205 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 1206105005206 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1206105005207 Phage tail protein; Region: Sipho_tail; cl17486 1206105005208 Phage-related minor tail protein [Function unknown]; Region: COG5280 1206105005209 tape measure domain; Region: tape_meas_nterm; TIGR02675 1206105005210 Phage-related protein [Function unknown]; Region: COG5412 1206105005211 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 1206105005212 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 1206105005213 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1206105005214 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 1206105005215 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 1206105005216 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1206105005217 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 1206105005218 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 1206105005219 Phage terminase large subunit; Region: Terminase_3; cl12054 1206105005220 Uncharacterized conserved protein [Function unknown]; Region: COG5484 1206105005221 Phage terminase small subunit; Region: Phage_terminase; pfam10668 1206105005222 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1206105005223 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 1206105005224 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 1206105005225 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u3; cd11540 1206105005226 putative metal binding site [ion binding]; other site 1206105005227 Domain of unknown function (DUF4373); Region: DUF4373; pfam14297 1206105005228 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 1206105005229 RecT family; Region: RecT; cl04285 1206105005230 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 1206105005231 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 1206105005232 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 1206105005233 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 1206105005234 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1206105005235 ORF6C domain; Region: ORF6C; pfam10552 1206105005236 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1206105005237 non-specific DNA binding site [nucleotide binding]; other site 1206105005238 salt bridge; other site 1206105005239 sequence-specific DNA binding site [nucleotide binding]; other site 1206105005240 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1206105005241 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1206105005242 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1206105005243 Int/Topo IB signature motif; other site 1206105005244 hypothetical protein; Provisional; Region: PRK10506 1206105005245 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1206105005246 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1206105005247 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1206105005248 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1206105005249 Walker A motif; other site 1206105005250 ATP binding site [chemical binding]; other site 1206105005251 Walker B motif; other site 1206105005252 amino acid transporter; Region: 2A0306; TIGR00909 1206105005253 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1206105005254 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1206105005255 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1206105005256 FeS/SAM binding site; other site 1206105005257 FtsX-like permease family; Region: FtsX; pfam02687 1206105005258 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1206105005259 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1206105005260 Walker A/P-loop; other site 1206105005261 ATP binding site [chemical binding]; other site 1206105005262 Q-loop/lid; other site 1206105005263 ABC transporter signature motif; other site 1206105005264 Walker B; other site 1206105005265 D-loop; other site 1206105005266 H-loop/switch region; other site 1206105005267 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1206105005268 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1206105005269 DNA-binding site [nucleotide binding]; DNA binding site 1206105005270 UTRA domain; Region: UTRA; pfam07702 1206105005271 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1206105005272 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1206105005273 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1206105005274 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1206105005275 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1206105005276 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1206105005277 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1206105005278 UbiA prenyltransferase family; Region: UbiA; pfam01040 1206105005279 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1206105005280 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1206105005281 substrate binding pocket [chemical binding]; other site 1206105005282 chain length determination region; other site 1206105005283 substrate-Mg2+ binding site; other site 1206105005284 catalytic residues [active] 1206105005285 aspartate-rich region 1; other site 1206105005286 active site lid residues [active] 1206105005287 aspartate-rich region 2; other site 1206105005288 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1206105005289 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1206105005290 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 1206105005291 Walker A/P-loop; other site 1206105005292 ATP binding site [chemical binding]; other site 1206105005293 Q-loop/lid; other site 1206105005294 ABC transporter signature motif; other site 1206105005295 Walker B; other site 1206105005296 D-loop; other site 1206105005297 H-loop/switch region; other site 1206105005298 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 1206105005299 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1206105005300 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206105005301 Walker A/P-loop; other site 1206105005302 ATP binding site [chemical binding]; other site 1206105005303 Q-loop/lid; other site 1206105005304 ABC transporter signature motif; other site 1206105005305 Walker B; other site 1206105005306 D-loop; other site 1206105005307 H-loop/switch region; other site 1206105005308 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1206105005309 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1206105005310 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1206105005311 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1206105005312 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1206105005313 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1206105005314 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1206105005315 DNA topoisomerase III; Provisional; Region: PRK07726 1206105005316 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1206105005317 active site 1206105005318 putative interdomain interaction site [polypeptide binding]; other site 1206105005319 putative metal-binding site [ion binding]; other site 1206105005320 putative nucleotide binding site [chemical binding]; other site 1206105005321 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1206105005322 domain I; other site 1206105005323 DNA binding groove [nucleotide binding] 1206105005324 phosphate binding site [ion binding]; other site 1206105005325 domain II; other site 1206105005326 domain III; other site 1206105005327 nucleotide binding site [chemical binding]; other site 1206105005328 catalytic site [active] 1206105005329 domain IV; other site 1206105005330 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1206105005331 Protein of unknown function (DUF1033); Region: DUF1033; pfam06279 1206105005332 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206105005333 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206105005334 WHG domain; Region: WHG; pfam13305 1206105005335 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1206105005336 substrate binding site [chemical binding]; other site 1206105005337 drug efflux system protein MdtG; Provisional; Region: PRK09874 1206105005338 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206105005339 putative substrate translocation pore; other site 1206105005340 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1206105005341 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1206105005342 Putative amino acid metabolism; Region: DUF1831; pfam08866 1206105005343 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1206105005344 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1206105005345 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1206105005346 catalytic residue [active] 1206105005347 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458 1206105005348 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1206105005349 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1206105005350 active site 1206105005351 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1206105005352 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1206105005353 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1206105005354 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1206105005355 ABC-ATPase subunit interface; other site 1206105005356 dimer interface [polypeptide binding]; other site 1206105005357 putative PBP binding regions; other site 1206105005358 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1206105005359 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1206105005360 metal binding site [ion binding]; metal-binding site 1206105005361 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1206105005362 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1206105005363 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1206105005364 ABC transporter; Region: ABC_tran_2; pfam12848 1206105005365 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1206105005366 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1206105005367 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 1206105005368 metal binding site [ion binding]; metal-binding site 1206105005369 putative dimer interface [polypeptide binding]; other site 1206105005370 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1206105005371 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1206105005372 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 1206105005373 dimer interface [polypeptide binding]; other site 1206105005374 conserved gate region; other site 1206105005375 ABC-ATPase subunit interface; other site 1206105005376 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1206105005377 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1206105005378 Walker A/P-loop; other site 1206105005379 ATP binding site [chemical binding]; other site 1206105005380 Q-loop/lid; other site 1206105005381 ABC transporter signature motif; other site 1206105005382 Walker B; other site 1206105005383 D-loop; other site 1206105005384 H-loop/switch region; other site 1206105005385 NIL domain; Region: NIL; pfam09383 1206105005386 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 1206105005387 FemAB family; Region: FemAB; pfam02388 1206105005388 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1206105005389 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1206105005390 glutaminase active site [active] 1206105005391 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1206105005392 dimer interface [polypeptide binding]; other site 1206105005393 active site 1206105005394 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1206105005395 dimer interface [polypeptide binding]; other site 1206105005396 active site 1206105005397 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1206105005398 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1206105005399 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1206105005400 Walker A/P-loop; other site 1206105005401 ATP binding site [chemical binding]; other site 1206105005402 Q-loop/lid; other site 1206105005403 ABC transporter signature motif; other site 1206105005404 Walker B; other site 1206105005405 D-loop; other site 1206105005406 H-loop/switch region; other site 1206105005407 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 1206105005408 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1206105005409 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1206105005410 Walker A/P-loop; other site 1206105005411 ATP binding site [chemical binding]; other site 1206105005412 Q-loop/lid; other site 1206105005413 ABC transporter signature motif; other site 1206105005414 Walker B; other site 1206105005415 D-loop; other site 1206105005416 H-loop/switch region; other site 1206105005417 hypothetical protein; Provisional; Region: PRK13661 1206105005418 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1206105005419 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1206105005420 active site 1206105005421 substrate binding site [chemical binding]; other site 1206105005422 metal binding site [ion binding]; metal-binding site 1206105005423 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1206105005424 YbbR-like protein; Region: YbbR; pfam07949 1206105005425 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1206105005426 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1206105005427 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1206105005428 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1206105005429 dimer interface [polypeptide binding]; other site 1206105005430 PYR/PP interface [polypeptide binding]; other site 1206105005431 TPP binding site [chemical binding]; other site 1206105005432 substrate binding site [chemical binding]; other site 1206105005433 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1206105005434 Domain of unknown function; Region: EKR; smart00890 1206105005435 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1206105005436 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1206105005437 TPP-binding site [chemical binding]; other site 1206105005438 dimer interface [polypeptide binding]; other site 1206105005439 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1206105005440 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1206105005441 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1206105005442 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1206105005443 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1206105005444 DNA binding residues [nucleotide binding] 1206105005445 putative dimer interface [polypeptide binding]; other site 1206105005446 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1206105005447 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1206105005448 HflX GTPase family; Region: HflX; cd01878 1206105005449 G1 box; other site 1206105005450 GTP/Mg2+ binding site [chemical binding]; other site 1206105005451 Switch I region; other site 1206105005452 G2 box; other site 1206105005453 G3 box; other site 1206105005454 Switch II region; other site 1206105005455 G4 box; other site 1206105005456 G5 box; other site 1206105005457 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1206105005458 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1206105005459 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1206105005460 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1206105005461 active site 1206105005462 catalytic site [active] 1206105005463 metal binding site [ion binding]; metal-binding site 1206105005464 dimer interface [polypeptide binding]; other site 1206105005465 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1206105005466 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1206105005467 NAD(P) binding site [chemical binding]; other site 1206105005468 active site 1206105005469 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1206105005470 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1206105005471 LicD family; Region: LicD; cl01378 1206105005472 O-Antigen ligase; Region: Wzy_C; pfam04932 1206105005473 putative glycosyl transferase; Provisional; Region: PRK10073 1206105005474 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1206105005475 active site 1206105005476 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1206105005477 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1206105005478 NAD(P) binding site [chemical binding]; other site 1206105005479 active site 1206105005480 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1206105005481 substrate binding site; other site 1206105005482 dimer interface; other site 1206105005483 SH3-like domain; Region: SH3_8; pfam13457 1206105005484 SH3-like domain; Region: SH3_8; pfam13457 1206105005485 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 1206105005486 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1206105005487 active site 1206105005488 SH3-like domain; Region: SH3_8; pfam13457 1206105005489 SH3-like domain; Region: SH3_8; pfam13457 1206105005490 SH3-like domain; Region: SH3_8; pfam13457 1206105005491 SH3-like domain; Region: SH3_8; pfam13457 1206105005492 LicD family; Region: LicD; cl01378 1206105005493 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1206105005494 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1206105005495 active site 1206105005496 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1206105005497 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1206105005498 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 1206105005499 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 1206105005500 Probable Catalytic site; other site 1206105005501 metal-binding site 1206105005502 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1206105005503 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1206105005504 Probable Catalytic site; other site 1206105005505 metal-binding site 1206105005506 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1206105005507 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206105005508 S-adenosylmethionine binding site [chemical binding]; other site 1206105005509 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1206105005510 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 1206105005511 Probable Catalytic site; other site 1206105005512 metal-binding site 1206105005513 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1206105005514 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1206105005515 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1206105005516 Walker A/P-loop; other site 1206105005517 ATP binding site [chemical binding]; other site 1206105005518 Q-loop/lid; other site 1206105005519 ABC transporter signature motif; other site 1206105005520 Walker B; other site 1206105005521 D-loop; other site 1206105005522 H-loop/switch region; other site 1206105005523 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 1206105005524 putative carbohydrate binding site [chemical binding]; other site 1206105005525 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1206105005526 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1206105005527 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 1206105005528 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1206105005529 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1206105005530 Ligand binding site; other site 1206105005531 Putative Catalytic site; other site 1206105005532 DXD motif; other site 1206105005533 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1206105005534 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1206105005535 NADP binding site [chemical binding]; other site 1206105005536 active site 1206105005537 putative substrate binding site [chemical binding]; other site 1206105005538 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1206105005539 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1206105005540 NAD binding site [chemical binding]; other site 1206105005541 substrate binding site [chemical binding]; other site 1206105005542 homodimer interface [polypeptide binding]; other site 1206105005543 active site 1206105005544 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1206105005545 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1206105005546 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1206105005547 substrate binding site; other site 1206105005548 tetramer interface; other site 1206105005549 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1206105005550 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 1206105005551 Probable Catalytic site; other site 1206105005552 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1206105005553 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1206105005554 active site 1206105005555 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1206105005556 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1206105005557 Probable Catalytic site; other site 1206105005558 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1206105005559 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1206105005560 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1206105005561 Mg++ binding site [ion binding]; other site 1206105005562 putative catalytic motif [active] 1206105005563 substrate binding site [chemical binding]; other site 1206105005564 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1206105005565 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1206105005566 active site 1206105005567 flavodoxin; Validated; Region: PRK07308 1206105005568 TspO/MBR family; Region: TspO_MBR; pfam03073 1206105005569 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206105005570 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206105005571 WHG domain; Region: WHG; pfam13305 1206105005572 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1206105005573 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1206105005574 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1206105005575 nucleoside/Zn binding site; other site 1206105005576 dimer interface [polypeptide binding]; other site 1206105005577 catalytic motif [active] 1206105005578 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1206105005579 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1206105005580 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 1206105005581 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 1206105005582 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 1206105005583 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1206105005584 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1206105005585 active site turn [active] 1206105005586 phosphorylation site [posttranslational modification] 1206105005587 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1206105005588 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1206105005589 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1206105005590 putative metal binding site [ion binding]; other site 1206105005591 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 1206105005592 putative hydrophobic ligand binding site [chemical binding]; other site 1206105005593 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1206105005594 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 1206105005595 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 1206105005596 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 1206105005597 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1206105005598 active site 1206105005599 phosphorylation site [posttranslational modification] 1206105005600 intermolecular recognition site; other site 1206105005601 dimerization interface [polypeptide binding]; other site 1206105005602 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1206105005603 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1206105005604 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1206105005605 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1206105005606 Histidine kinase; Region: His_kinase; pfam06580 1206105005607 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1206105005608 ATP binding site [chemical binding]; other site 1206105005609 Mg2+ binding site [ion binding]; other site 1206105005610 G-X-G motif; other site 1206105005611 Protein of unknown function, DUF624; Region: DUF624; cl02369 1206105005612 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1206105005613 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 1206105005614 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1206105005615 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206105005616 dimer interface [polypeptide binding]; other site 1206105005617 ABC-ATPase subunit interface; other site 1206105005618 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1206105005619 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206105005620 dimer interface [polypeptide binding]; other site 1206105005621 conserved gate region; other site 1206105005622 putative PBP binding loops; other site 1206105005623 ABC-ATPase subunit interface; other site 1206105005624 CAAX protease self-immunity; Region: Abi; pfam02517 1206105005625 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1206105005626 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1206105005627 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1206105005628 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1206105005629 DNA binding residues [nucleotide binding] 1206105005630 dimer interface [polypeptide binding]; other site 1206105005631 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1206105005632 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1206105005633 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206105005634 Walker A/P-loop; other site 1206105005635 ATP binding site [chemical binding]; other site 1206105005636 Q-loop/lid; other site 1206105005637 ABC transporter signature motif; other site 1206105005638 Walker B; other site 1206105005639 D-loop; other site 1206105005640 H-loop/switch region; other site 1206105005641 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1206105005642 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1206105005643 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1206105005644 Walker A/P-loop; other site 1206105005645 ATP binding site [chemical binding]; other site 1206105005646 Q-loop/lid; other site 1206105005647 ABC transporter signature motif; other site 1206105005648 Walker B; other site 1206105005649 D-loop; other site 1206105005650 H-loop/switch region; other site 1206105005651 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1206105005652 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1206105005653 active site 1206105005654 HIGH motif; other site 1206105005655 dimer interface [polypeptide binding]; other site 1206105005656 KMSKS motif; other site 1206105005657 Right handed beta helix region; Region: Beta_helix; pfam13229 1206105005658 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 1206105005659 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 1206105005660 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 1206105005661 V-type ATP synthase subunit I; Validated; Region: PRK05771 1206105005662 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1206105005663 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206105005664 dimer interface [polypeptide binding]; other site 1206105005665 conserved gate region; other site 1206105005666 putative PBP binding loops; other site 1206105005667 ABC-ATPase subunit interface; other site 1206105005668 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1206105005669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206105005670 dimer interface [polypeptide binding]; other site 1206105005671 conserved gate region; other site 1206105005672 putative PBP binding loops; other site 1206105005673 ABC-ATPase subunit interface; other site 1206105005674 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1206105005675 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1206105005676 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 1206105005677 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 1206105005678 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1206105005679 generic binding surface I; other site 1206105005680 generic binding surface II; other site 1206105005681 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1206105005682 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1206105005683 DNA binding site [nucleotide binding] 1206105005684 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1206105005685 putative dimerization interface [polypeptide binding]; other site 1206105005686 putative ligand binding site [chemical binding]; other site 1206105005687 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 1206105005688 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1206105005689 Walker A motif; other site 1206105005690 ATP binding site [chemical binding]; other site 1206105005691 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1206105005692 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1206105005693 Int/Topo IB signature motif; other site 1206105005694 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1206105005695 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1206105005696 DNA binding residues [nucleotide binding] 1206105005697 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 1206105005698 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1206105005699 Cna protein B-type domain; Region: Cna_B; pfam05738 1206105005700 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1206105005701 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 1206105005702 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 1206105005703 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 1206105005704 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1206105005705 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1206105005706 LytTr DNA-binding domain; Region: LytTR; smart00850 1206105005707 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1206105005708 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1206105005709 active site 1206105005710 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1206105005711 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1206105005712 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1206105005713 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1206105005714 PemK-like protein; Region: PemK; pfam02452 1206105005715 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 1206105005716 Catalytic site; other site 1206105005717 Staphylococcal nuclease homologue; Region: SNase; pfam00565 1206105005718 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1206105005719 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1206105005720 dimer interface [polypeptide binding]; other site 1206105005721 ssDNA binding site [nucleotide binding]; other site 1206105005722 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1206105005723 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1206105005724 Helix-turn-helix domain; Region: HTH_28; pfam13518 1206105005725 Helix-turn-helix domain; Region: HTH_28; pfam13518 1206105005726 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1206105005727 HTH-like domain; Region: HTH_21; pfam13276 1206105005728 Integrase core domain; Region: rve; pfam00665 1206105005729 Integrase core domain; Region: rve_2; pfam13333 1206105005730 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1206105005731 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1206105005732 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1206105005733 putative transposase OrfB; Reviewed; Region: PHA02517 1206105005734 HTH-like domain; Region: HTH_21; pfam13276 1206105005735 Integrase core domain; Region: rve; pfam00665 1206105005736 Integrase core domain; Region: rve_3; pfam13683 1206105005737 Transposase; Region: HTH_Tnp_1; pfam01527 1206105005738 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1206105005739 transposase/IS protein; Provisional; Region: PRK09183 1206105005740 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206105005741 Walker A motif; other site 1206105005742 ATP binding site [chemical binding]; other site 1206105005743 Walker B motif; other site 1206105005744 arginine finger; other site 1206105005745 Preprotein translocase subunit; Region: YajC; cl00806 1206105005746 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 1206105005747 Transposase domain (DUF772); Region: DUF772; pfam05598 1206105005748 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1206105005749 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1206105005750 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1206105005751 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1206105005752 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1206105005753 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 1206105005754 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1206105005755 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1206105005756 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1206105005757 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1206105005758 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1206105005759 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1206105005760 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1206105005761 active site 1206105005762 homodimer interface [polypeptide binding]; other site 1206105005763 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 1206105005764 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1206105005765 putative NAD(P) binding site [chemical binding]; other site 1206105005766 active site 1206105005767 putative substrate binding site [chemical binding]; other site 1206105005768 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1206105005769 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 1206105005770 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1206105005771 NAD(P) binding site [chemical binding]; other site 1206105005772 homodimer interface [polypeptide binding]; other site 1206105005773 substrate binding site [chemical binding]; other site 1206105005774 active site 1206105005775 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 1206105005776 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1206105005777 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1206105005778 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 1206105005779 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1206105005780 inhibitor-cofactor binding pocket; inhibition site 1206105005781 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206105005782 catalytic residue [active] 1206105005783 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1206105005784 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1206105005785 putative trimer interface [polypeptide binding]; other site 1206105005786 putative CoA binding site [chemical binding]; other site 1206105005787 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1206105005788 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1206105005789 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1206105005790 NAD(P) binding site [chemical binding]; other site 1206105005791 homodimer interface [polypeptide binding]; other site 1206105005792 substrate binding site [chemical binding]; other site 1206105005793 active site 1206105005794 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1206105005795 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1206105005796 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1206105005797 Chain length determinant protein; Region: Wzz; cl15801 1206105005798 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1206105005799 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1206105005800 Transposase domain (DUF772); Region: DUF772; pfam05598 1206105005801 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1206105005802 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1206105005803 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1206105005804 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 1206105005805 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1206105005806 Cna protein B-type domain; Region: Cna_B; pfam05738 1206105005807 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1206105005808 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1206105005809 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1206105005810 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1206105005811 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1206105005812 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1206105005813 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1206105005814 Transposase; Region: HTH_Tnp_1; pfam01527 1206105005815 putative transposase OrfB; Reviewed; Region: PHA02517 1206105005816 HTH-like domain; Region: HTH_21; pfam13276 1206105005817 Integrase core domain; Region: rve; pfam00665 1206105005818 Integrase core domain; Region: rve_2; pfam13333 1206105005819 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1206105005820 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1206105005821 active site 1206105005822 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 1206105005823 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1206105005824 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1206105005825 Walker A/P-loop; other site 1206105005826 ATP binding site [chemical binding]; other site 1206105005827 Q-loop/lid; other site 1206105005828 ABC transporter signature motif; other site 1206105005829 Walker B; other site 1206105005830 D-loop; other site 1206105005831 H-loop/switch region; other site 1206105005832 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1206105005833 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1206105005834 FtsX-like permease family; Region: FtsX; pfam02687 1206105005835 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1206105005836 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1206105005837 active site 1206105005838 phosphorylation site [posttranslational modification] 1206105005839 intermolecular recognition site; other site 1206105005840 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1206105005841 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1206105005842 active site 1206105005843 dimerization interface [polypeptide binding]; other site 1206105005844 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1206105005845 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1206105005846 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1206105005847 dimer interface [polypeptide binding]; other site 1206105005848 phosphorylation site [posttranslational modification] 1206105005849 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1206105005850 ATP binding site [chemical binding]; other site 1206105005851 Mg2+ binding site [ion binding]; other site 1206105005852 G-X-G motif; other site 1206105005853 Superinfection exclusion protein B; Region: SieB; pfam14163 1206105005854 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1206105005855 Catalytic site; other site 1206105005856 Staphylococcal nuclease homologue; Region: SNase; pfam00565 1206105005857 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1206105005858 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1206105005859 dimer interface [polypeptide binding]; other site 1206105005860 ssDNA binding site [nucleotide binding]; other site 1206105005861 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1206105005862 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 1206105005863 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1206105005864 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 1206105005865 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1206105005866 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1206105005867 nucleotide binding region [chemical binding]; other site 1206105005868 ATP-binding site [chemical binding]; other site 1206105005869 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1206105005870 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 1206105005871 conjugal transfer relaxase TraI; Provisional; Region: PRK13878 1206105005872 PemK-like protein; Region: PemK; pfam02452 1206105005873 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1206105005874 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1206105005875 catalytic residue [active] 1206105005876 CHAP domain; Region: CHAP; cl17642 1206105005877 Toprim-like; Region: Toprim_2; pfam13155 1206105005878 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 1206105005879 AAA-like domain; Region: AAA_10; pfam12846 1206105005880 Alpha-helical domain of GINS complex proteins; Sld5, Psf1, Psf2 and Psf3; Region: GINS_A; cl17012 1206105005881 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206105005882 conserved gate region; other site 1206105005883 CBF/Mak21 family; Region: CBF; cl10505 1206105005884 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1206105005885 Walker A motif; other site 1206105005886 ATP binding site [chemical binding]; other site 1206105005887 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 1206105005888 Walker B motif; other site 1206105005889 LXG domain of WXG superfamily; Region: LXG; pfam04740 1206105005890 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 1206105005891 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1206105005892 CHAP domain; Region: CHAP; pfam05257 1206105005893 Cna protein B-type domain; Region: Cna_B; pfam05738 1206105005894 Cna protein B-type domain; Region: Cna_B; pfam05738 1206105005895 Cna protein B-type domain; Region: Cna_B; pfam05738 1206105005896 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 1206105005897 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 1206105005898 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 1206105005899 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1206105005900 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1206105005901 non-specific DNA binding site [nucleotide binding]; other site 1206105005902 salt bridge; other site 1206105005903 sequence-specific DNA binding site [nucleotide binding]; other site 1206105005904 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1206105005905 non-specific DNA binding site [nucleotide binding]; other site 1206105005906 salt bridge; other site 1206105005907 sequence-specific DNA binding site [nucleotide binding]; other site 1206105005908 GTP-binding protein LepA; Provisional; Region: PRK05433 1206105005909 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1206105005910 G1 box; other site 1206105005911 putative GEF interaction site [polypeptide binding]; other site 1206105005912 GTP/Mg2+ binding site [chemical binding]; other site 1206105005913 Switch I region; other site 1206105005914 G2 box; other site 1206105005915 G3 box; other site 1206105005916 Switch II region; other site 1206105005917 G4 box; other site 1206105005918 G5 box; other site 1206105005919 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1206105005920 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1206105005921 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1206105005922 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1206105005923 Sterol carrier protein domain; Region: SCP2_2; pfam13530 1206105005924 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 1206105005925 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1206105005926 Clp amino terminal domain; Region: Clp_N; pfam02861 1206105005927 Clp amino terminal domain; Region: Clp_N; pfam02861 1206105005928 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206105005929 Walker A motif; other site 1206105005930 ATP binding site [chemical binding]; other site 1206105005931 Walker B motif; other site 1206105005932 arginine finger; other site 1206105005933 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206105005934 Walker A motif; other site 1206105005935 ATP binding site [chemical binding]; other site 1206105005936 Walker B motif; other site 1206105005937 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1206105005938 DoxX; Region: DoxX; cl17842 1206105005939 adenylosuccinate lyase; Provisional; Region: PRK07492 1206105005940 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1206105005941 tetramer interface [polypeptide binding]; other site 1206105005942 active site 1206105005943 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1206105005944 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1206105005945 NAD binding site [chemical binding]; other site 1206105005946 ATP-grasp domain; Region: ATP-grasp; pfam02222 1206105005947 xanthine permease; Region: pbuX; TIGR03173 1206105005948 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1206105005949 active site 1206105005950 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1206105005951 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1206105005952 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1206105005953 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1206105005954 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1206105005955 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1206105005956 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1206105005957 putative dimer interface [polypeptide binding]; other site 1206105005958 putative anticodon binding site; other site 1206105005959 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1206105005960 homodimer interface [polypeptide binding]; other site 1206105005961 motif 1; other site 1206105005962 motif 2; other site 1206105005963 active site 1206105005964 motif 3; other site 1206105005965 aspartate aminotransferase; Provisional; Region: PRK05764 1206105005966 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1206105005967 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206105005968 homodimer interface [polypeptide binding]; other site 1206105005969 catalytic residue [active] 1206105005970 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 1206105005971 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 1206105005972 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1206105005973 active site 1206105005974 catalytic site [active] 1206105005975 substrate binding site [chemical binding]; other site 1206105005976 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1206105005977 ATP binding site [chemical binding]; other site 1206105005978 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1206105005979 Amino acid permease; Region: AA_permease_2; pfam13520 1206105005980 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1206105005981 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1206105005982 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1206105005983 generic binding surface II; other site 1206105005984 generic binding surface I; other site 1206105005985 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1206105005986 active site 1206105005987 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1206105005988 active site 1206105005989 catalytic site [active] 1206105005990 substrate binding site [chemical binding]; other site 1206105005991 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1206105005992 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1206105005993 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1206105005994 dimer interface [polypeptide binding]; other site 1206105005995 motif 1; other site 1206105005996 active site 1206105005997 motif 2; other site 1206105005998 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1206105005999 putative deacylase active site [active] 1206105006000 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1206105006001 active site 1206105006002 motif 3; other site 1206105006003 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1206105006004 anticodon binding site; other site 1206105006005 RIP metalloprotease RseP; Region: TIGR00054 1206105006006 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1206105006007 active site 1206105006008 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1206105006009 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1206105006010 protein binding site [polypeptide binding]; other site 1206105006011 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1206105006012 putative substrate binding region [chemical binding]; other site 1206105006013 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1206105006014 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1206105006015 NAD binding site [chemical binding]; other site 1206105006016 homodimer interface [polypeptide binding]; other site 1206105006017 active site 1206105006018 Predicted membrane protein [Function unknown]; Region: COG2364 1206105006019 AIPR protein; Region: AIPR; pfam10592 1206105006020 AAA domain; Region: AAA_12; pfam13087 1206105006021 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1206105006022 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1206105006023 active site 1206105006024 ATP binding site [chemical binding]; other site 1206105006025 substrate binding site [chemical binding]; other site 1206105006026 activation loop (A-loop); other site 1206105006027 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1206105006028 AAA domain; Region: AAA_11; pfam13086 1206105006029 Part of AAA domain; Region: AAA_19; pfam13245 1206105006030 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1206105006031 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1206105006032 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1206105006033 FeS assembly protein SufB; Region: sufB; TIGR01980 1206105006034 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1206105006035 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1206105006036 trimerization site [polypeptide binding]; other site 1206105006037 active site 1206105006038 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1206105006039 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1206105006040 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1206105006041 catalytic residue [active] 1206105006042 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1206105006043 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1206105006044 FeS assembly protein SufD; Region: sufD; TIGR01981 1206105006045 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1206105006046 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1206105006047 Walker A/P-loop; other site 1206105006048 ATP binding site [chemical binding]; other site 1206105006049 Q-loop/lid; other site 1206105006050 ABC transporter signature motif; other site 1206105006051 Walker B; other site 1206105006052 D-loop; other site 1206105006053 H-loop/switch region; other site 1206105006054 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1206105006055 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1206105006056 hinge region; other site 1206105006057 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1206105006058 putative nucleotide binding site [chemical binding]; other site 1206105006059 uridine monophosphate binding site [chemical binding]; other site 1206105006060 homohexameric interface [polypeptide binding]; other site 1206105006061 elongation factor Ts; Provisional; Region: tsf; PRK09377 1206105006062 UBA/TS-N domain; Region: UBA; pfam00627 1206105006063 Elongation factor TS; Region: EF_TS; pfam00889 1206105006064 Elongation factor TS; Region: EF_TS; pfam00889 1206105006065 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1206105006066 rRNA interaction site [nucleotide binding]; other site 1206105006067 S8 interaction site; other site 1206105006068 putative laminin-1 binding site; other site 1206105006069 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1206105006070 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1206105006071 Coenzyme A binding pocket [chemical binding]; other site 1206105006072 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1206105006073 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1206105006074 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1206105006075 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 1206105006076 OxaA-like protein precursor; Provisional; Region: PRK02463 1206105006077 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1206105006078 hypothetical protein; Provisional; Region: PRK07758 1206105006079 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1206105006080 DALR anticodon binding domain; Region: DALR_1; pfam05746 1206105006081 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1206105006082 dimer interface [polypeptide binding]; other site 1206105006083 motif 1; other site 1206105006084 active site 1206105006085 motif 2; other site 1206105006086 motif 3; other site 1206105006087 Recombination protein O N terminal; Region: RecO_N; pfam11967 1206105006088 DNA repair protein RecO; Region: reco; TIGR00613 1206105006089 Recombination protein O C terminal; Region: RecO_C; pfam02565 1206105006090 GTPase Era; Reviewed; Region: era; PRK00089 1206105006091 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1206105006092 G1 box; other site 1206105006093 GTP/Mg2+ binding site [chemical binding]; other site 1206105006094 Switch I region; other site 1206105006095 G2 box; other site 1206105006096 Switch II region; other site 1206105006097 G3 box; other site 1206105006098 G4 box; other site 1206105006099 G5 box; other site 1206105006100 KH domain; Region: KH_2; pfam07650 1206105006101 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1206105006102 metal-binding heat shock protein; Provisional; Region: PRK00016 1206105006103 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 1206105006104 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 1206105006105 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1206105006106 Zn2+ binding site [ion binding]; other site 1206105006107 Mg2+ binding site [ion binding]; other site 1206105006108 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1206105006109 PhoH-like protein; Region: PhoH; pfam02562 1206105006110 Yqey-like protein; Region: YqeY; pfam09424 1206105006111 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1206105006112 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1206105006113 metal binding site 2 [ion binding]; metal-binding site 1206105006114 putative DNA binding helix; other site 1206105006115 metal binding site 1 [ion binding]; metal-binding site 1206105006116 dimer interface [polypeptide binding]; other site 1206105006117 structural Zn2+ binding site [ion binding]; other site 1206105006118 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 1206105006119 homoserine kinase; Provisional; Region: PRK01212 1206105006120 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1206105006121 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1206105006122 threonine synthase; Reviewed; Region: PRK06721 1206105006123 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1206105006124 homodimer interface [polypeptide binding]; other site 1206105006125 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206105006126 catalytic residue [active] 1206105006127 homoserine dehydrogenase; Provisional; Region: PRK06349 1206105006128 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1206105006129 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1206105006130 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1206105006131 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1206105006132 dimerization interface [polypeptide binding]; other site 1206105006133 putative DNA binding site [nucleotide binding]; other site 1206105006134 putative Zn2+ binding site [ion binding]; other site 1206105006135 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1206105006136 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1206105006137 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1206105006138 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1206105006139 active site 1206105006140 substrate binding site [chemical binding]; other site 1206105006141 metal binding site [ion binding]; metal-binding site 1206105006142 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1206105006143 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1206105006144 DNA-binding site [nucleotide binding]; DNA binding site 1206105006145 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1206105006146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206105006147 homodimer interface [polypeptide binding]; other site 1206105006148 catalytic residue [active] 1206105006149 Predicted transcriptional regulators [Transcription]; Region: COG1695 1206105006150 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1206105006151 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1206105006152 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1206105006153 active site 1206105006154 xanthine permease; Region: pbuX; TIGR03173 1206105006155 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 1206105006156 guanine deaminase; Region: guan_deamin; TIGR02967 1206105006157 active site 1206105006158 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1206105006159 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1206105006160 catalytic core [active] 1206105006161 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1206105006162 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1206105006163 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1206105006164 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1206105006165 putative active site [active] 1206105006166 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1206105006167 active site turn [active] 1206105006168 phosphorylation site [posttranslational modification] 1206105006169 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1206105006170 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1206105006171 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1206105006172 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1206105006173 putative active site [active] 1206105006174 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1206105006175 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1206105006176 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1206105006177 HPr interaction site; other site 1206105006178 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1206105006179 active site 1206105006180 phosphorylation site [posttranslational modification] 1206105006181 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1206105006182 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_1; cd10805 1206105006183 putative active site [active] 1206105006184 YdjC motif; other site 1206105006185 Mg binding site [ion binding]; other site 1206105006186 putative homodimer interface [polypeptide binding]; other site 1206105006187 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1206105006188 Phosphate transporter family; Region: PHO4; pfam01384 1206105006189 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1206105006190 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1206105006191 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1206105006192 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1206105006193 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1206105006194 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1206105006195 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1206105006196 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1206105006197 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1206105006198 Competence protein; Region: Competence; pfam03772 1206105006199 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1206105006200 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1206105006201 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1206105006202 catalytic motif [active] 1206105006203 Zn binding site [ion binding]; other site 1206105006204 SLBB domain; Region: SLBB; pfam10531 1206105006205 comEA protein; Region: comE; TIGR01259 1206105006206 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1206105006207 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1206105006208 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1206105006209 protein binding site [polypeptide binding]; other site 1206105006210 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1206105006211 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1206105006212 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1206105006213 active site 1206105006214 (T/H)XGH motif; other site 1206105006215 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1206105006216 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206105006217 S-adenosylmethionine binding site [chemical binding]; other site 1206105006218 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 1206105006219 Protein of unknown function (DUF964); Region: DUF964; pfam06133 1206105006220 pyruvate carboxylase; Reviewed; Region: PRK12999 1206105006221 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1206105006222 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1206105006223 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1206105006224 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1206105006225 active site 1206105006226 catalytic residues [active] 1206105006227 metal binding site [ion binding]; metal-binding site 1206105006228 homodimer binding site [polypeptide binding]; other site 1206105006229 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1206105006230 carboxyltransferase (CT) interaction site; other site 1206105006231 biotinylation site [posttranslational modification]; other site 1206105006232 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1206105006233 hypothetical protein; Provisional; Region: PRK13666 1206105006234 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1206105006235 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1206105006236 ATP binding site [chemical binding]; other site 1206105006237 putative Mg++ binding site [ion binding]; other site 1206105006238 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1206105006239 nucleotide binding region [chemical binding]; other site 1206105006240 ATP-binding site [chemical binding]; other site 1206105006241 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1206105006242 HRDC domain; Region: HRDC; pfam00570 1206105006243 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1206105006244 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1206105006245 G1 box; other site 1206105006246 putative GEF interaction site [polypeptide binding]; other site 1206105006247 GTP/Mg2+ binding site [chemical binding]; other site 1206105006248 Switch I region; other site 1206105006249 G2 box; other site 1206105006250 G3 box; other site 1206105006251 Switch II region; other site 1206105006252 G4 box; other site 1206105006253 G5 box; other site 1206105006254 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1206105006255 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1206105006256 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1206105006257 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1206105006258 active site 1206105006259 hypothetical protein; Provisional; Region: PRK04387 1206105006260 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1206105006261 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 1206105006262 putative Cl- selectivity filter; other site 1206105006263 putative pore gating glutamate residue; other site 1206105006264 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1206105006265 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1206105006266 active site 1206105006267 Cna protein B-type domain; Region: Cna_B; pfam05738 1206105006268 Cna protein B-type domain; Region: Cna_B; pfam05738 1206105006269 Cna protein B-type domain; Region: Cna_B; pfam05738 1206105006270 Cna protein B-type domain; Region: Cna_B; pfam05738 1206105006271 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1206105006272 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1206105006273 non-specific DNA binding site [nucleotide binding]; other site 1206105006274 salt bridge; other site 1206105006275 sequence-specific DNA binding site [nucleotide binding]; other site 1206105006276 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1206105006277 Zn2+ binding site [ion binding]; other site 1206105006278 Mg2+ binding site [ion binding]; other site 1206105006279 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 1206105006280 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1206105006281 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1206105006282 active site 1206105006283 HIGH motif; other site 1206105006284 KMSK motif region; other site 1206105006285 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1206105006286 tRNA binding surface [nucleotide binding]; other site 1206105006287 anticodon binding site; other site 1206105006288 UGMP family protein; Validated; Region: PRK09604 1206105006289 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1206105006290 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1206105006291 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1206105006292 Coenzyme A binding pocket [chemical binding]; other site 1206105006293 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1206105006294 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1206105006295 Coenzyme A binding pocket [chemical binding]; other site 1206105006296 Glycoprotease family; Region: Peptidase_M22; pfam00814 1206105006297 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1206105006298 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1206105006299 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1206105006300 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1206105006301 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1206105006302 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 1206105006303 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 1206105006304 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1206105006305 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 1206105006306 Repair protein; Region: Repair_PSII; pfam04536 1206105006307 Short C-terminal domain; Region: SHOCT; pfam09851 1206105006308 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1206105006309 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1206105006310 motif II; other site 1206105006311 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 1206105006312 Ligand Binding Site [chemical binding]; other site 1206105006313 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1206105006314 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1206105006315 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1206105006316 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1206105006317 catalytic residue [active] 1206105006318 putative FPP diphosphate binding site; other site 1206105006319 putative FPP binding hydrophobic cleft; other site 1206105006320 dimer interface [polypeptide binding]; other site 1206105006321 putative IPP diphosphate binding site; other site 1206105006322 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1206105006323 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1206105006324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206105006325 dimer interface [polypeptide binding]; other site 1206105006326 conserved gate region; other site 1206105006327 ABC-ATPase subunit interface; other site 1206105006328 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1206105006329 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1206105006330 Walker A/P-loop; other site 1206105006331 ATP binding site [chemical binding]; other site 1206105006332 Q-loop/lid; other site 1206105006333 ABC transporter signature motif; other site 1206105006334 Walker B; other site 1206105006335 D-loop; other site 1206105006336 H-loop/switch region; other site 1206105006337 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1206105006338 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1206105006339 lipoyl attachment site [posttranslational modification]; other site 1206105006340 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1206105006341 ArsC family; Region: ArsC; pfam03960 1206105006342 putative ArsC-like catalytic residues; other site 1206105006343 putative TRX-like catalytic residues [active] 1206105006344 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1206105006345 Mga helix-turn-helix domain; Region: Mga; pfam05043 1206105006346 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1206105006347 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1206105006348 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1206105006349 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1206105006350 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1206105006351 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1206105006352 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1206105006353 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1206105006354 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1206105006355 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1206105006356 non-specific DNA binding site [nucleotide binding]; other site 1206105006357 salt bridge; other site 1206105006358 sequence-specific DNA binding site [nucleotide binding]; other site 1206105006359 Cupin domain; Region: Cupin_2; pfam07883 1206105006360 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1206105006361 Predicted membrane protein [Function unknown]; Region: COG4392 1206105006362 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1206105006363 active site 1206105006364 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1206105006365 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1206105006366 dimer interface [polypeptide binding]; other site 1206105006367 active site 1206105006368 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1206105006369 folate binding site [chemical binding]; other site 1206105006370 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1206105006371 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1206105006372 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 1206105006373 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206105006374 S-adenosylmethionine binding site [chemical binding]; other site 1206105006375 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1206105006376 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1206105006377 RF-1 domain; Region: RF-1; pfam00472 1206105006378 thymidine kinase; Provisional; Region: PRK04296 1206105006379 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 1206105006380 L-aspartate oxidase; Provisional; Region: PRK06175 1206105006381 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1206105006382 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1206105006383 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1206105006384 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1206105006385 dimer interface [polypeptide binding]; other site 1206105006386 PYR/PP interface [polypeptide binding]; other site 1206105006387 TPP binding site [chemical binding]; other site 1206105006388 substrate binding site [chemical binding]; other site 1206105006389 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1206105006390 Domain of unknown function; Region: EKR; smart00890 1206105006391 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1206105006392 4Fe-4S binding domain; Region: Fer4; pfam00037 1206105006393 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1206105006394 TPP-binding site [chemical binding]; other site 1206105006395 dimer interface [polypeptide binding]; other site 1206105006396 putative oxidoreductase; Provisional; Region: PRK12831 1206105006397 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1206105006398 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1206105006399 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 1206105006400 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 1206105006401 FAD binding pocket [chemical binding]; other site 1206105006402 FAD binding motif [chemical binding]; other site 1206105006403 phosphate binding motif [ion binding]; other site 1206105006404 beta-alpha-beta structure motif; other site 1206105006405 NAD binding pocket [chemical binding]; other site 1206105006406 Iron coordination center [ion binding]; other site 1206105006407 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1206105006408 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 1206105006409 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 1206105006410 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 1206105006411 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 1206105006412 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 1206105006413 CPxP motif; other site 1206105006414 DsrE/DsrF-like family; Region: DrsE; cl00672 1206105006415 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1206105006416 selenophosphate synthetase; Provisional; Region: PRK00943 1206105006417 dimerization interface [polypeptide binding]; other site 1206105006418 putative ATP binding site [chemical binding]; other site 1206105006419 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1206105006420 cysteine desulfurase family protein; Region: am_tr_V_EF2568; TIGR01977 1206105006421 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1206105006422 catalytic residue [active] 1206105006423 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1206105006424 Ligand binding site; other site 1206105006425 metal-binding site 1206105006426 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 1206105006427 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1206105006428 catalytic loop [active] 1206105006429 iron binding site [ion binding]; other site 1206105006430 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1206105006431 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1206105006432 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1206105006433 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1206105006434 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1206105006435 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 1206105006436 xanthine permease; Region: pbuX; TIGR03173 1206105006437 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1206105006438 homotrimer interaction site [polypeptide binding]; other site 1206105006439 putative active site [active] 1206105006440 carbamate kinase; Reviewed; Region: PRK12686 1206105006441 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1206105006442 putative substrate binding site [chemical binding]; other site 1206105006443 nucleotide binding site [chemical binding]; other site 1206105006444 nucleotide binding site [chemical binding]; other site 1206105006445 homodimer interface [polypeptide binding]; other site 1206105006446 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 1206105006447 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1206105006448 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1206105006449 putative selenium metabolism hydrolase; Region: selenium_YgeY; TIGR03526 1206105006450 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 1206105006451 putative metal binding site [ion binding]; other site 1206105006452 putative dimer interface [polypeptide binding]; other site 1206105006453 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 1206105006454 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1206105006455 catalytic residue [active] 1206105006456 D-hydantoinase; Region: D-hydantoinase; TIGR02033 1206105006457 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 1206105006458 tetramer interface [polypeptide binding]; other site 1206105006459 active site 1206105006460 putative selenate reductase, YgfK subunit; Region: Se_ygfK; TIGR03315 1206105006461 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1206105006462 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 1206105006463 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1206105006464 active site 1206105006465 putative substrate binding pocket [chemical binding]; other site 1206105006466 YheO-like PAS domain; Region: PAS_6; pfam08348 1206105006467 HTH domain; Region: HTH_22; pfam13309 1206105006468 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1206105006469 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1206105006470 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1206105006471 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1206105006472 catalytic triad [active] 1206105006473 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 1206105006474 active site 1206105006475 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1206105006476 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1206105006477 Beta-lactamase; Region: Beta-lactamase; pfam00144 1206105006478 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1206105006479 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1206105006480 active site 1206105006481 metal binding site [ion binding]; metal-binding site 1206105006482 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1206105006483 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1206105006484 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1206105006485 Walker A/P-loop; other site 1206105006486 ATP binding site [chemical binding]; other site 1206105006487 Q-loop/lid; other site 1206105006488 ABC transporter signature motif; other site 1206105006489 Walker B; other site 1206105006490 D-loop; other site 1206105006491 H-loop/switch region; other site 1206105006492 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1206105006493 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1206105006494 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206105006495 Walker A/P-loop; other site 1206105006496 ATP binding site [chemical binding]; other site 1206105006497 Q-loop/lid; other site 1206105006498 ABC transporter signature motif; other site 1206105006499 Walker B; other site 1206105006500 D-loop; other site 1206105006501 H-loop/switch region; other site 1206105006502 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206105006503 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206105006504 Guanylate kinase; Region: Guanylate_kin; pfam00625 1206105006505 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1206105006506 catalytic site [active] 1206105006507 G-X2-G-X-G-K; other site 1206105006508 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1206105006509 beta-galactosidase; Region: BGL; TIGR03356 1206105006510 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1206105006511 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1206105006512 active site turn [active] 1206105006513 phosphorylation site [posttranslational modification] 1206105006514 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1206105006515 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1206105006516 HPr interaction site; other site 1206105006517 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1206105006518 active site 1206105006519 phosphorylation site [posttranslational modification] 1206105006520 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1206105006521 CAT RNA binding domain; Region: CAT_RBD; smart01061 1206105006522 PRD domain; Region: PRD; pfam00874 1206105006523 PRD domain; Region: PRD; pfam00874 1206105006524 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 1206105006525 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1206105006526 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1206105006527 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 1206105006528 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 1206105006529 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1206105006530 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1206105006531 hinge; other site 1206105006532 active site 1206105006533 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1206105006534 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1206105006535 gamma subunit interface [polypeptide binding]; other site 1206105006536 epsilon subunit interface [polypeptide binding]; other site 1206105006537 LBP interface [polypeptide binding]; other site 1206105006538 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1206105006539 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1206105006540 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1206105006541 alpha subunit interaction interface [polypeptide binding]; other site 1206105006542 Walker A motif; other site 1206105006543 ATP binding site [chemical binding]; other site 1206105006544 Walker B motif; other site 1206105006545 inhibitor binding site; inhibition site 1206105006546 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1206105006547 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1206105006548 core domain interface [polypeptide binding]; other site 1206105006549 delta subunit interface [polypeptide binding]; other site 1206105006550 epsilon subunit interface [polypeptide binding]; other site 1206105006551 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1206105006552 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1206105006553 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1206105006554 beta subunit interaction interface [polypeptide binding]; other site 1206105006555 Walker A motif; other site 1206105006556 ATP binding site [chemical binding]; other site 1206105006557 Walker B motif; other site 1206105006558 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1206105006559 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1206105006560 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1206105006561 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1206105006562 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1206105006563 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1206105006564 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1206105006565 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1206105006566 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1206105006567 SmpB-tmRNA interface; other site 1206105006568 ribonuclease R; Region: RNase_R; TIGR02063 1206105006569 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1206105006570 RNB domain; Region: RNB; pfam00773 1206105006571 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1206105006572 RNA binding site [nucleotide binding]; other site 1206105006573 Esterase/lipase [General function prediction only]; Region: COG1647 1206105006574 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1206105006575 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1206105006576 Coenzyme A binding pocket [chemical binding]; other site 1206105006577 Uncharacterized conserved protein [Function unknown]; Region: COG3592 1206105006578 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1206105006579 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1206105006580 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1206105006581 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1206105006582 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1206105006583 homodimer interface [polypeptide binding]; other site 1206105006584 NAD binding pocket [chemical binding]; other site 1206105006585 ATP binding pocket [chemical binding]; other site 1206105006586 Mg binding site [ion binding]; other site 1206105006587 active-site loop [active] 1206105006588 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1206105006589 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1206105006590 active site 1206105006591 Predicted membrane protein [Function unknown]; Region: COG2246 1206105006592 GtrA-like protein; Region: GtrA; pfam04138 1206105006593 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1206105006594 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1206105006595 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1206105006596 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1206105006597 ribonuclease Y; Region: RNase_Y; TIGR03319 1206105006598 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1206105006599 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1206105006600 DNA binding site [nucleotide binding] 1206105006601 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1206105006602 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1206105006603 ring oligomerisation interface [polypeptide binding]; other site 1206105006604 ATP/Mg binding site [chemical binding]; other site 1206105006605 stacking interactions; other site 1206105006606 hinge regions; other site 1206105006607 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1206105006608 oligomerisation interface [polypeptide binding]; other site 1206105006609 mobile loop; other site 1206105006610 roof hairpin; other site 1206105006611 CAAX protease self-immunity; Region: Abi; pfam02517 1206105006612 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1206105006613 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1206105006614 CoA binding domain; Region: CoA_binding; pfam02629 1206105006615 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1206105006616 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206105006617 Walker A/P-loop; other site 1206105006618 ATP binding site [chemical binding]; other site 1206105006619 Q-loop/lid; other site 1206105006620 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1206105006621 ABC transporter signature motif; other site 1206105006622 Walker B; other site 1206105006623 D-loop; other site 1206105006624 H-loop/switch region; other site 1206105006625 ABC transporter; Region: ABC_tran_2; pfam12848 1206105006626 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1206105006627 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1206105006628 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1206105006629 DNA-binding site [nucleotide binding]; DNA binding site 1206105006630 TrkA-C domain; Region: TrkA_C; pfam02080 1206105006631 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1206105006632 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1206105006633 Walker A/P-loop; other site 1206105006634 ATP binding site [chemical binding]; other site 1206105006635 Q-loop/lid; other site 1206105006636 ABC transporter signature motif; other site 1206105006637 Walker B; other site 1206105006638 D-loop; other site 1206105006639 H-loop/switch region; other site 1206105006640 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1206105006641 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206105006642 dimer interface [polypeptide binding]; other site 1206105006643 conserved gate region; other site 1206105006644 putative PBP binding loops; other site 1206105006645 ABC-ATPase subunit interface; other site 1206105006646 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1206105006647 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1206105006648 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 1206105006649 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1206105006650 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1206105006651 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1206105006652 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1206105006653 glycerate kinase; Region: TIGR00045 1206105006654 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1206105006655 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1206105006656 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1206105006657 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1206105006658 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1206105006659 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1206105006660 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206105006661 dimer interface [polypeptide binding]; other site 1206105006662 conserved gate region; other site 1206105006663 putative PBP binding loops; other site 1206105006664 ABC-ATPase subunit interface; other site 1206105006665 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 1206105006666 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206105006667 dimer interface [polypeptide binding]; other site 1206105006668 conserved gate region; other site 1206105006669 putative PBP binding loops; other site 1206105006670 ABC-ATPase subunit interface; other site 1206105006671 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1206105006672 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1206105006673 Walker A/P-loop; other site 1206105006674 ATP binding site [chemical binding]; other site 1206105006675 Q-loop/lid; other site 1206105006676 ABC transporter signature motif; other site 1206105006677 Walker B; other site 1206105006678 D-loop; other site 1206105006679 H-loop/switch region; other site 1206105006680 TOBE domain; Region: TOBE_2; pfam08402 1206105006681 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1206105006682 non-specific DNA binding site [nucleotide binding]; other site 1206105006683 salt bridge; other site 1206105006684 sequence-specific DNA binding site [nucleotide binding]; other site 1206105006685 Cupin domain; Region: Cupin_2; pfam07883 1206105006686 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 1206105006687 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1206105006688 NADP binding site [chemical binding]; other site 1206105006689 dimer interface [polypeptide binding]; other site 1206105006690 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 1206105006691 phosphopantothenoylcysteine decarboxylase, streptococcal; Region: coaC_strep; TIGR02113 1206105006692 Flavoprotein; Region: Flavoprotein; pfam02441 1206105006693 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1206105006694 Predicted membrane protein [Function unknown]; Region: COG4684 1206105006695 FemAB family; Region: FemAB; pfam02388 1206105006696 QueT transporter; Region: QueT; pfam06177 1206105006697 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1206105006698 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1206105006699 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1206105006700 AAA domain; Region: AAA_30; pfam13604 1206105006701 Family description; Region: UvrD_C_2; pfam13538 1206105006702 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1206105006703 catalytic core [active] 1206105006704 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1206105006705 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1206105006706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206105006707 S-adenosylmethionine binding site [chemical binding]; other site 1206105006708 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 1206105006709 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1206105006710 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1206105006711 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1206105006712 Divalent cation transporter; Region: MgtE; pfam01769 1206105006713 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1206105006714 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1206105006715 active site 1206105006716 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1206105006717 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1206105006718 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1206105006719 synthetase active site [active] 1206105006720 NTP binding site [chemical binding]; other site 1206105006721 metal binding site [ion binding]; metal-binding site 1206105006722 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1206105006723 putative active site [active] 1206105006724 putative metal binding residues [ion binding]; other site 1206105006725 signature motif; other site 1206105006726 putative triphosphate binding site [ion binding]; other site 1206105006727 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1206105006728 catalytic residues [active] 1206105006729 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1206105006730 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1206105006731 non-specific DNA binding site [nucleotide binding]; other site 1206105006732 salt bridge; other site 1206105006733 sequence-specific DNA binding site [nucleotide binding]; other site 1206105006734 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 1206105006735 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1206105006736 active site 1206105006737 Zn binding site [ion binding]; other site 1206105006738 Competence protein CoiA-like family; Region: CoiA; pfam06054 1206105006739 adaptor protein; Provisional; Region: PRK02315 1206105006740 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1206105006741 ArsC family; Region: ArsC; pfam03960 1206105006742 putative catalytic residues [active] 1206105006743 thiol/disulfide switch; other site 1206105006744 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1206105006745 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1206105006746 active site 1206105006747 HIGH motif; other site 1206105006748 dimer interface [polypeptide binding]; other site 1206105006749 KMSKS motif; other site 1206105006750 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1206105006751 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1206105006752 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1206105006753 Walker A/P-loop; other site 1206105006754 ATP binding site [chemical binding]; other site 1206105006755 Q-loop/lid; other site 1206105006756 ABC transporter signature motif; other site 1206105006757 Walker B; other site 1206105006758 D-loop; other site 1206105006759 H-loop/switch region; other site 1206105006760 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1206105006761 amidase catalytic site [active] 1206105006762 Zn binding residues [ion binding]; other site 1206105006763 substrate binding site [chemical binding]; other site 1206105006764 Bacterial SH3 domain; Region: SH3_5; pfam08460 1206105006765 Holin family; Region: Phage_holin_4; pfam05105 1206105006766 Phage tail protein; Region: Sipho_tail; cl17486 1206105006767 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1206105006768 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1206105006769 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 1206105006770 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 1206105006771 Phage capsid family; Region: Phage_capsid; pfam05065 1206105006772 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1206105006773 oligomer interface [polypeptide binding]; other site 1206105006774 active site residues [active] 1206105006775 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 1206105006776 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1206105006777 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1206105006778 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1206105006779 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 1206105006780 YopX protein; Region: YopX; pfam09643 1206105006781 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1206105006782 DNA binding residues [nucleotide binding] 1206105006783 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1206105006784 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1206105006785 Int/Topo IB signature motif; other site 1206105006786 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1206105006787 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1206105006788 S-adenosylmethionine binding site [chemical binding]; other site 1206105006789 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u3; cd11540 1206105006790 putative metal binding site [ion binding]; other site 1206105006791 Recombination protein U; Region: RecU; cl01314 1206105006792 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1206105006793 Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin...; Region: UBCc; cl00154 1206105006794 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1206105006795 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1206105006796 non-specific DNA binding site [nucleotide binding]; other site 1206105006797 salt bridge; other site 1206105006798 sequence-specific DNA binding site [nucleotide binding]; other site 1206105006799 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1206105006800 non-specific DNA binding site [nucleotide binding]; other site 1206105006801 salt bridge; other site 1206105006802 sequence-specific DNA binding site [nucleotide binding]; other site 1206105006803 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1206105006804 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1206105006805 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1206105006806 catalytic residues [active] 1206105006807 catalytic nucleophile [active] 1206105006808 Recombinase; Region: Recombinase; pfam07508 1206105006809 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1206105006810 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1206105006811 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1206105006812 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1206105006813 motif II; other site 1206105006814 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1206105006815 Helix-turn-helix domain; Region: HTH_28; pfam13518 1206105006816 Helix-turn-helix domain; Region: HTH_28; pfam13518 1206105006817 HTH-like domain; Region: HTH_21; pfam13276 1206105006818 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1206105006819 Integrase core domain; Region: rve; pfam00665 1206105006820 Integrase core domain; Region: rve_2; pfam13333 1206105006821 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1206105006822 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 1206105006823 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1206105006824 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1206105006825 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1206105006826 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1206105006827 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1206105006828 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1206105006829 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1206105006830 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1206105006831 LRR adjacent; Region: LRR_adjacent; pfam08191 1206105006832 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1206105006833 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 1206105006834 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1206105006835 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1206105006836 ATP binding site [chemical binding]; other site 1206105006837 putative Mg++ binding site [ion binding]; other site 1206105006838 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1206105006839 nucleotide binding region [chemical binding]; other site 1206105006840 ATP-binding site [chemical binding]; other site 1206105006841 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206105006842 AAA domain; Region: AAA_23; pfam13476 1206105006843 Walker A/P-loop; other site 1206105006844 ATP binding site [chemical binding]; other site 1206105006845 Q-loop/lid; other site 1206105006846 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1206105006847 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206105006848 ABC transporter signature motif; other site 1206105006849 Walker B; other site 1206105006850 D-loop; other site 1206105006851 H-loop/switch region; other site 1206105006852 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1206105006853 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1206105006854 active site 1206105006855 metal binding site [ion binding]; metal-binding site 1206105006856 DNA binding site [nucleotide binding] 1206105006857 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1206105006858 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1206105006859 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1206105006860 putative acyl-acceptor binding pocket; other site 1206105006861 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1206105006862 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206105006863 S-adenosylmethionine binding site [chemical binding]; other site 1206105006864 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1206105006865 GIY-YIG motif/motif A; other site 1206105006866 putative active site [active] 1206105006867 putative metal binding site [ion binding]; other site 1206105006868 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1206105006869 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1206105006870 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1206105006871 dimer interface [polypeptide binding]; other site 1206105006872 ADP-ribose binding site [chemical binding]; other site 1206105006873 active site 1206105006874 nudix motif; other site 1206105006875 metal binding site [ion binding]; metal-binding site 1206105006876 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 1206105006877 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1206105006878 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1206105006879 nudix motif; other site 1206105006880 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1206105006881 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1206105006882 Coenzyme A binding pocket [chemical binding]; other site 1206105006883 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1206105006884 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1206105006885 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1206105006886 minor groove reading motif; other site 1206105006887 helix-hairpin-helix signature motif; other site 1206105006888 substrate binding pocket [chemical binding]; other site 1206105006889 active site 1206105006890 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1206105006891 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1206105006892 DNA binding and oxoG recognition site [nucleotide binding] 1206105006893 recombination regulator RecX; Provisional; Region: recX; PRK14135 1206105006894 TRAM domain; Region: TRAM; pfam01938 1206105006895 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1206105006896 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206105006897 S-adenosylmethionine binding site [chemical binding]; other site 1206105006898 Predicted membrane protein [Function unknown]; Region: COG2261 1206105006899 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 1206105006900 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1206105006901 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1206105006902 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1206105006903 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 1206105006904 Amino acid permease; Region: AA_permease_2; pfam13520 1206105006905 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1206105006906 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1206105006907 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1206105006908 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 1206105006909 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1206105006910 core dimer interface [polypeptide binding]; other site 1206105006911 peripheral dimer interface [polypeptide binding]; other site 1206105006912 L10 interface [polypeptide binding]; other site 1206105006913 L11 interface [polypeptide binding]; other site 1206105006914 putative EF-Tu interaction site [polypeptide binding]; other site 1206105006915 putative EF-G interaction site [polypeptide binding]; other site 1206105006916 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1206105006917 23S rRNA interface [nucleotide binding]; other site 1206105006918 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1206105006919 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1206105006920 mRNA/rRNA interface [nucleotide binding]; other site 1206105006921 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1206105006922 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1206105006923 23S rRNA interface [nucleotide binding]; other site 1206105006924 L7/L12 interface [polypeptide binding]; other site 1206105006925 putative thiostrepton binding site; other site 1206105006926 L25 interface [polypeptide binding]; other site 1206105006927 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1206105006928 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1206105006929 ABC transporter; Region: ABC_tran_2; pfam12848 1206105006930 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1206105006931 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 1206105006932 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1206105006933 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 1206105006934 putative L-serine binding site [chemical binding]; other site 1206105006935 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1206105006936 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1206105006937 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_2; cd08769 1206105006938 SxDxEG motif; other site 1206105006939 putative active site [active] 1206105006940 putative metal binding site [ion binding]; other site 1206105006941 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1206105006942 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1206105006943 oligomer interface [polypeptide binding]; other site 1206105006944 active site 1206105006945 metal binding site [ion binding]; metal-binding site 1206105006946 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1206105006947 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1206105006948 peptide binding site [polypeptide binding]; other site 1206105006949 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1206105006950 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1206105006951 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1206105006952 putative active site [active] 1206105006953 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1206105006954 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1206105006955 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1206105006956 putative homodimer interface [polypeptide binding]; other site 1206105006957 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1206105006958 heterodimer interface [polypeptide binding]; other site 1206105006959 homodimer interface [polypeptide binding]; other site 1206105006960 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1206105006961 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1206105006962 FOG: CBS domain [General function prediction only]; Region: COG0517 1206105006963 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1206105006964 conserved hypothetical integral membrane protein; Region: TIGR03766 1206105006965 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1206105006966 FAD binding domain; Region: FAD_binding_4; pfam01565 1206105006967 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1206105006968 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1206105006969 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1206105006970 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1206105006971 active site 1206105006972 putative catalytic site [active] 1206105006973 DNA binding site [nucleotide binding] 1206105006974 putative phosphate binding site [ion binding]; other site 1206105006975 metal binding site A [ion binding]; metal-binding site 1206105006976 AP binding site [nucleotide binding]; other site 1206105006977 metal binding site B [ion binding]; metal-binding site 1206105006978 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1206105006979 active site 1206105006980 catalytic site [active] 1206105006981 substrate binding site [chemical binding]; other site 1206105006982 putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143 1206105006983 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1206105006984 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1206105006985 catalytic residue [active] 1206105006986 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1206105006987 catalytic residues [active] 1206105006988 peroxiredoxin; Region: AhpC; TIGR03137 1206105006989 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1206105006990 dimer interface [polypeptide binding]; other site 1206105006991 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1206105006992 catalytic triad [active] 1206105006993 peroxidatic and resolving cysteines [active] 1206105006994 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1206105006995 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206105006996 S-adenosylmethionine binding site [chemical binding]; other site 1206105006997 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1206105006998 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1206105006999 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1206105007000 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1206105007001 putative hydrolase; Provisional; Region: PRK02113 1206105007002 Protein of unknown function (DUF975); Region: DUF975; cl10504 1206105007003 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1206105007004 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1206105007005 oligomer interface [polypeptide binding]; other site 1206105007006 active site 1206105007007 metal binding site [ion binding]; metal-binding site 1206105007008 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 1206105007009 DltD N-terminal region; Region: DltD_N; pfam04915 1206105007010 DltD central region; Region: DltD_M; pfam04918 1206105007011 DltD C-terminal region; Region: DltD_C; pfam04914 1206105007012 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1206105007013 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1206105007014 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1206105007015 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1206105007016 acyl-activating enzyme (AAE) consensus motif; other site 1206105007017 AMP binding site [chemical binding]; other site 1206105007018 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1206105007019 FtsX-like permease family; Region: FtsX; pfam02687 1206105007020 FtsX-like permease family; Region: FtsX; pfam02687 1206105007021 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1206105007022 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1206105007023 Walker A/P-loop; other site 1206105007024 ATP binding site [chemical binding]; other site 1206105007025 Q-loop/lid; other site 1206105007026 ABC transporter signature motif; other site 1206105007027 Walker B; other site 1206105007028 D-loop; other site 1206105007029 H-loop/switch region; other site 1206105007030 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1206105007031 ATP cone domain; Region: ATP-cone; pfam03477 1206105007032 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1206105007033 effector binding site; other site 1206105007034 active site 1206105007035 Zn binding site [ion binding]; other site 1206105007036 glycine loop; other site 1206105007037 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 1206105007038 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1206105007039 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1206105007040 active site 1206105007041 DNA polymerase IV; Validated; Region: PRK02406 1206105007042 DNA binding site [nucleotide binding] 1206105007043 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1206105007044 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206105007045 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1206105007046 Walker A/P-loop; other site 1206105007047 ATP binding site [chemical binding]; other site 1206105007048 Q-loop/lid; other site 1206105007049 ABC transporter signature motif; other site 1206105007050 Walker B; other site 1206105007051 D-loop; other site 1206105007052 H-loop/switch region; other site 1206105007053 Predicted methyltransferases [General function prediction only]; Region: COG0313 1206105007054 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1206105007055 putative SAM binding site [chemical binding]; other site 1206105007056 putative homodimer interface [polypeptide binding]; other site 1206105007057 Protein of unknown function (DUF972); Region: DUF972; pfam06156 1206105007058 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1206105007059 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1206105007060 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206105007061 Walker A motif; other site 1206105007062 ATP binding site [chemical binding]; other site 1206105007063 Walker B motif; other site 1206105007064 arginine finger; other site 1206105007065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870 1206105007066 thymidylate kinase; Validated; Region: tmk; PRK00698 1206105007067 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1206105007068 TMP-binding site; other site 1206105007069 ATP-binding site [chemical binding]; other site 1206105007070 recombination protein RecR; Reviewed; Region: recR; PRK00076 1206105007071 RecR protein; Region: RecR; pfam02132 1206105007072 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1206105007073 putative active site [active] 1206105007074 putative metal-binding site [ion binding]; other site 1206105007075 tetramer interface [polypeptide binding]; other site 1206105007076 Putative transcription activator [Transcription]; Region: TenA; COG0819 1206105007077 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1206105007078 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1206105007079 Walker A/P-loop; other site 1206105007080 ATP binding site [chemical binding]; other site 1206105007081 Q-loop/lid; other site 1206105007082 ABC transporter signature motif; other site 1206105007083 Walker B; other site 1206105007084 D-loop; other site 1206105007085 H-loop/switch region; other site 1206105007086 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 1206105007087 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1206105007088 Walker A/P-loop; other site 1206105007089 ATP binding site [chemical binding]; other site 1206105007090 Q-loop/lid; other site 1206105007091 ABC transporter signature motif; other site 1206105007092 Walker B; other site 1206105007093 D-loop; other site 1206105007094 H-loop/switch region; other site 1206105007095 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 1206105007096 TraX protein; Region: TraX; cl05434 1206105007097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206105007098 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1206105007099 putative substrate translocation pore; other site 1206105007100 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1206105007101 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206105007102 putative substrate translocation pore; other site 1206105007103 Predicted transcriptional regulators [Transcription]; Region: COG1733 1206105007104 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1206105007105 putative DNA binding site [nucleotide binding]; other site 1206105007106 putative Zn2+ binding site [ion binding]; other site 1206105007107 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1206105007108 dimer interface [polypeptide binding]; other site 1206105007109 substrate binding site [chemical binding]; other site 1206105007110 ATP binding site [chemical binding]; other site 1206105007111 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1206105007112 thiamine phosphate binding site [chemical binding]; other site 1206105007113 active site 1206105007114 pyrophosphate binding site [ion binding]; other site 1206105007115 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1206105007116 substrate binding site [chemical binding]; other site 1206105007117 multimerization interface [polypeptide binding]; other site 1206105007118 ATP binding site [chemical binding]; other site 1206105007119 thiW protein; Region: thiW; TIGR02359 1206105007120 hypothetical protein; Validated; Region: PRK00153 1206105007121 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1206105007122 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206105007123 Walker A motif; other site 1206105007124 ATP binding site [chemical binding]; other site 1206105007125 Walker B motif; other site 1206105007126 arginine finger; other site 1206105007127 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 1206105007128 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 1206105007129 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1206105007130 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1206105007131 NAD binding site [chemical binding]; other site 1206105007132 homodimer interface [polypeptide binding]; other site 1206105007133 active site 1206105007134 substrate binding site [chemical binding]; other site 1206105007135 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 1206105007136 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1206105007137 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1206105007138 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1206105007139 active site residue [active] 1206105007140 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1206105007141 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1206105007142 nucleotide binding site [chemical binding]; other site 1206105007143 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 1206105007144 Rhomboid family; Region: Rhomboid; pfam01694 1206105007145 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1206105007146 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1206105007147 esterase; Provisional; Region: PRK10566 1206105007148 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1206105007149 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1206105007150 conserved hypothetical integral membrane protein; Region: TIGR03766 1206105007151 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1206105007152 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1206105007153 Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415 1206105007154 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1206105007155 active site 1206105007156 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 1206105007157 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1206105007158 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1206105007159 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 1206105007160 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 1206105007161 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1206105007162 Phage-related protein [Function unknown]; Region: PblB; COG4926 1206105007163 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1206105007164 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1206105007165 Peptidase family M23; Region: Peptidase_M23; pfam01551 1206105007166 Phage tail protein; Region: Sipho_tail; cl17486 1206105007167 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 1206105007168 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 1206105007169 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 1206105007170 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 1206105007171 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 1206105007172 oligomerization interface [polypeptide binding]; other site 1206105007173 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1206105007174 Phage capsid family; Region: Phage_capsid; pfam05065 1206105007175 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 1206105007176 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 1206105007177 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1206105007178 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 1206105007179 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1206105007180 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 1206105007181 Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354 1206105007182 YopX protein; Region: YopX; pfam09643 1206105007183 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 1206105007184 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1206105007185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206105007186 Walker A motif; other site 1206105007187 ATP binding site [chemical binding]; other site 1206105007188 Walker B motif; other site 1206105007189 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1206105007190 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1206105007191 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 1206105007192 RecT family; Region: RecT; pfam03837 1206105007193 Helix-turn-helix domain; Region: HTH_17; pfam12728 1206105007194 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1206105007195 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1206105007196 non-specific DNA binding site [nucleotide binding]; other site 1206105007197 salt bridge; other site 1206105007198 sequence-specific DNA binding site [nucleotide binding]; other site 1206105007199 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1206105007200 Ion channel; Region: Ion_trans_2; pfam07885 1206105007201 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1206105007202 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1206105007203 Int/Topo IB signature motif; other site 1206105007204 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1206105007205 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1206105007206 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1206105007207 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1206105007208 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1206105007209 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1206105007210 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1206105007211 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1206105007212 active site 1206105007213 dimer interface [polypeptide binding]; other site 1206105007214 motif 1; other site 1206105007215 motif 2; other site 1206105007216 motif 3; other site 1206105007217 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1206105007218 anticodon binding site; other site 1206105007219 4-oxalocrotonate tautomerase; Provisional; Region: PRK02220 1206105007220 active site 1 [active] 1206105007221 dimer interface [polypeptide binding]; other site 1206105007222 hexamer interface [polypeptide binding]; other site 1206105007223 active site 2 [active] 1206105007224 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1206105007225 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1206105007226 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1206105007227 dimer interface [polypeptide binding]; other site 1206105007228 phosphorylation site [posttranslational modification] 1206105007229 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1206105007230 ATP binding site [chemical binding]; other site 1206105007231 Mg2+ binding site [ion binding]; other site 1206105007232 G-X-G motif; other site 1206105007233 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1206105007234 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1206105007235 active site 1206105007236 phosphorylation site [posttranslational modification] 1206105007237 intermolecular recognition site; other site 1206105007238 dimerization interface [polypeptide binding]; other site 1206105007239 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1206105007240 DNA binding site [nucleotide binding] 1206105007241 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1206105007242 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1206105007243 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1206105007244 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 1206105007245 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1206105007246 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1206105007247 putative active site [active] 1206105007248 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 1206105007249 active site 1206105007250 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 1206105007251 hypothetical protein; Provisional; Region: PRK12378 1206105007252 hypothetical protein; Provisional; Region: PRK13670 1206105007253 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 1206105007254 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1206105007255 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206105007256 S-adenosylmethionine binding site [chemical binding]; other site 1206105007257 Oligomerisation domain; Region: Oligomerisation; cl00519 1206105007258 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1206105007259 Zn2+ binding site [ion binding]; other site 1206105007260 Mg2+ binding site [ion binding]; other site 1206105007261 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1206105007262 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1206105007263 active site 1206105007264 (T/H)XGH motif; other site 1206105007265 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 1206105007266 GTPase YqeH; Provisional; Region: PRK13796 1206105007267 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1206105007268 GTP/Mg2+ binding site [chemical binding]; other site 1206105007269 G4 box; other site 1206105007270 G5 box; other site 1206105007271 G1 box; other site 1206105007272 Switch I region; other site 1206105007273 G2 box; other site 1206105007274 G3 box; other site 1206105007275 Switch II region; other site 1206105007276 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1206105007277 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1206105007278 active site 1206105007279 motif I; other site 1206105007280 motif II; other site 1206105007281 acetyl-CoA carboxylase subunit alpha; Provisional; Region: PRK12319 1206105007282 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1206105007283 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 1206105007284 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1206105007285 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1206105007286 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1206105007287 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1206105007288 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1206105007289 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1206105007290 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1206105007291 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1206105007292 carboxyltransferase (CT) interaction site; other site 1206105007293 biotinylation site [posttranslational modification]; other site 1206105007294 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1206105007295 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1206105007296 dimer interface [polypeptide binding]; other site 1206105007297 active site 1206105007298 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1206105007299 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1206105007300 NAD(P) binding site [chemical binding]; other site 1206105007301 homotetramer interface [polypeptide binding]; other site 1206105007302 homodimer interface [polypeptide binding]; other site 1206105007303 active site 1206105007304 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1206105007305 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1206105007306 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 1206105007307 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1206105007308 FMN binding site [chemical binding]; other site 1206105007309 substrate binding site [chemical binding]; other site 1206105007310 putative catalytic residue [active] 1206105007311 acyl carrier protein; Provisional; Region: acpP; PRK00982 1206105007312 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1206105007313 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1206105007314 dimer interface [polypeptide binding]; other site 1206105007315 active site 1206105007316 CoA binding pocket [chemical binding]; other site 1206105007317 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1206105007318 MarR family; Region: MarR_2; pfam12802 1206105007319 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 1206105007320 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1206105007321 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1206105007322 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1206105007323 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 1206105007324 putative ADP-binding pocket [chemical binding]; other site 1206105007325 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1206105007326 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1206105007327 general stress protein 13; Validated; Region: PRK08059 1206105007328 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1206105007329 RNA binding site [nucleotide binding]; other site 1206105007330 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1206105007331 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1206105007332 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206105007333 homodimer interface [polypeptide binding]; other site 1206105007334 catalytic residue [active] 1206105007335 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 1206105007336 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1206105007337 active site 1206105007338 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1206105007339 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1206105007340 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1206105007341 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 1206105007342 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1206105007343 putative ligand binding site [chemical binding]; other site 1206105007344 NAD binding site [chemical binding]; other site 1206105007345 catalytic site [active] 1206105007346 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1206105007347 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1206105007348 active site 1206105007349 metal binding site [ion binding]; metal-binding site 1206105007350 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1206105007351 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1206105007352 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1206105007353 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1206105007354 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1206105007355 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1206105007356 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206105007357 dimer interface [polypeptide binding]; other site 1206105007358 conserved gate region; other site 1206105007359 putative PBP binding loops; other site 1206105007360 ABC-ATPase subunit interface; other site 1206105007361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206105007362 dimer interface [polypeptide binding]; other site 1206105007363 conserved gate region; other site 1206105007364 putative PBP binding loops; other site 1206105007365 ABC-ATPase subunit interface; other site 1206105007366 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1206105007367 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1206105007368 Walker A/P-loop; other site 1206105007369 ATP binding site [chemical binding]; other site 1206105007370 Q-loop/lid; other site 1206105007371 ABC transporter signature motif; other site 1206105007372 Walker B; other site 1206105007373 D-loop; other site 1206105007374 H-loop/switch region; other site 1206105007375 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1206105007376 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1206105007377 Ligand binding site; other site 1206105007378 Putative Catalytic site; other site 1206105007379 DXD motif; other site 1206105007380 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1206105007381 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1206105007382 TrkA-N domain; Region: TrkA_N; pfam02254 1206105007383 TrkA-C domain; Region: TrkA_C; pfam02080 1206105007384 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1206105007385 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1206105007386 active site 1206105007387 phosphorylation site [posttranslational modification] 1206105007388 intermolecular recognition site; other site 1206105007389 dimerization interface [polypeptide binding]; other site 1206105007390 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1206105007391 DNA binding residues [nucleotide binding] 1206105007392 dimerization interface [polypeptide binding]; other site 1206105007393 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1206105007394 Histidine kinase; Region: HisKA_3; pfam07730 1206105007395 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1206105007396 ATP binding site [chemical binding]; other site 1206105007397 Mg2+ binding site [ion binding]; other site 1206105007398 G-X-G motif; other site 1206105007399 Predicted membrane protein [Function unknown]; Region: COG4758 1206105007400 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1206105007401 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1206105007402 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1206105007403 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1206105007404 YceG-like family; Region: YceG; pfam02618 1206105007405 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1206105007406 dimerization interface [polypeptide binding]; other site 1206105007407 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1206105007408 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1206105007409 motif II; other site 1206105007410 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1206105007411 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1206105007412 active site 1206105007413 homodimer interface [polypeptide binding]; other site 1206105007414 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1206105007415 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1206105007416 trimer interface [polypeptide binding]; other site 1206105007417 putative metal binding site [ion binding]; other site 1206105007418 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1206105007419 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1206105007420 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1206105007421 Walker A/P-loop; other site 1206105007422 ATP binding site [chemical binding]; other site 1206105007423 Q-loop/lid; other site 1206105007424 ABC transporter signature motif; other site 1206105007425 Walker B; other site 1206105007426 D-loop; other site 1206105007427 H-loop/switch region; other site 1206105007428 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1206105007429 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1206105007430 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206105007431 Walker A/P-loop; other site 1206105007432 ATP binding site [chemical binding]; other site 1206105007433 Q-loop/lid; other site 1206105007434 ABC transporter signature motif; other site 1206105007435 Walker B; other site 1206105007436 D-loop; other site 1206105007437 H-loop/switch region; other site 1206105007438 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 1206105007439 Protein of unknown function (DUF1447); Region: DUF1447; pfam07288 1206105007440 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1206105007441 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1206105007442 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1206105007443 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1206105007444 DNA-binding site [nucleotide binding]; DNA binding site 1206105007445 RNA-binding motif; other site 1206105007446 hypothetical protein; Reviewed; Region: PRK00024 1206105007447 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1206105007448 MPN+ (JAMM) motif; other site 1206105007449 Zinc-binding site [ion binding]; other site 1206105007450 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1206105007451 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1206105007452 motif II; other site 1206105007453 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 1206105007454 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1206105007455 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1206105007456 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1206105007457 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1206105007458 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1206105007459 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1206105007460 active site 1206105007461 HIGH motif; other site 1206105007462 nucleotide binding site [chemical binding]; other site 1206105007463 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1206105007464 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1206105007465 active site 1206105007466 KMSKS motif; other site 1206105007467 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1206105007468 tRNA binding surface [nucleotide binding]; other site 1206105007469 anticodon binding site; other site 1206105007470 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1206105007471 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1206105007472 dimer interface [polypeptide binding]; other site 1206105007473 catalytic triad [active] 1206105007474 peroxidatic and resolving cysteines [active] 1206105007475 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1206105007476 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1206105007477 CoA binding domain; Region: CoA_binding; pfam02629 1206105007478 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1206105007479 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1206105007480 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1206105007481 Ligand Binding Site [chemical binding]; other site 1206105007482 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1206105007483 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1206105007484 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1206105007485 NAD(P) binding site [chemical binding]; other site 1206105007486 active site 1206105007487 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1206105007488 active site 1206105007489 substrate binding site [chemical binding]; other site 1206105007490 trimer interface [polypeptide binding]; other site 1206105007491 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1206105007492 CoA binding site [chemical binding]; other site 1206105007493 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1206105007494 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1206105007495 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1206105007496 dimerization interface [polypeptide binding]; other site 1206105007497 Sugar transport protein; Region: Sugar_transport; pfam06800 1206105007498 D-ribose pyranase; Provisional; Region: PRK11797 1206105007499 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1206105007500 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1206105007501 substrate binding site [chemical binding]; other site 1206105007502 dimer interface [polypeptide binding]; other site 1206105007503 ATP binding site [chemical binding]; other site 1206105007504 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1206105007505 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1206105007506 DNA binding site [nucleotide binding] 1206105007507 domain linker motif; other site 1206105007508 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1206105007509 dimerization interface [polypeptide binding]; other site 1206105007510 ligand binding site [chemical binding]; other site 1206105007511 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1206105007512 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1206105007513 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 1206105007514 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1206105007515 active site 1206105007516 P-loop; other site 1206105007517 phosphorylation site [posttranslational modification] 1206105007518 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1206105007519 PRD domain; Region: PRD; pfam00874 1206105007520 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1206105007521 active site 1206105007522 P-loop; other site 1206105007523 phosphorylation site [posttranslational modification] 1206105007524 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1206105007525 active site 1206105007526 phosphorylation site [posttranslational modification] 1206105007527 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1206105007528 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1206105007529 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 1206105007530 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1206105007531 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1206105007532 Amidinotransferase; Region: Amidinotransf; cl12043 1206105007533 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1206105007534 dimer interface [polypeptide binding]; other site 1206105007535 Alkaline phosphatase homologues; Region: alkPPc; smart00098 1206105007536 active site 1206105007537 MutS domain III; Region: MutS_III; pfam05192 1206105007538 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206105007539 Walker A/P-loop; other site 1206105007540 ATP binding site [chemical binding]; other site 1206105007541 Q-loop/lid; other site 1206105007542 ABC transporter signature motif; other site 1206105007543 Walker B; other site 1206105007544 D-loop; other site 1206105007545 H-loop/switch region; other site 1206105007546 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 1206105007547 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 1206105007548 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1206105007549 catalytic residue [active] 1206105007550 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 1206105007551 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 1206105007552 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 1206105007553 active site 1206105007554 phosphorylation site [posttranslational modification] 1206105007555 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1206105007556 active pocket/dimerization site; other site 1206105007557 active site 1206105007558 phosphorylation site [posttranslational modification] 1206105007559 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1206105007560 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206105007561 Walker A motif; other site 1206105007562 ATP binding site [chemical binding]; other site 1206105007563 Walker B motif; other site 1206105007564 arginine finger; other site 1206105007565 PRD domain; Region: PRD; pfam00874 1206105007566 Transcriptional antiterminator [Transcription]; Region: COG3933 1206105007567 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1206105007568 active site 1206105007569 active pocket/dimerization site; other site 1206105007570 phosphorylation site [posttranslational modification] 1206105007571 PRD domain; Region: PRD; pfam00874 1206105007572 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1206105007573 catalytic core [active] 1206105007574 amidase; Provisional; Region: PRK06529 1206105007575 Amidase; Region: Amidase; cl11426 1206105007576 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1206105007577 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1206105007578 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1206105007579 FtsX-like permease family; Region: FtsX; pfam02687 1206105007580 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1206105007581 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1206105007582 Walker A/P-loop; other site 1206105007583 ATP binding site [chemical binding]; other site 1206105007584 Q-loop/lid; other site 1206105007585 ABC transporter signature motif; other site 1206105007586 Walker B; other site 1206105007587 D-loop; other site 1206105007588 H-loop/switch region; other site 1206105007589 HlyD family secretion protein; Region: HlyD_2; pfam12700 1206105007590 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1206105007591 active site residue [active] 1206105007592 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1206105007593 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 1206105007594 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1206105007595 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1206105007596 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1206105007597 active site residue [active] 1206105007598 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1206105007599 active site residue [active] 1206105007600 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 1206105007601 putative homodimer interface [polypeptide binding]; other site 1206105007602 putative homotetramer interface [polypeptide binding]; other site 1206105007603 putative metal binding site [ion binding]; other site 1206105007604 putative homodimer-homodimer interface [polypeptide binding]; other site 1206105007605 putative allosteric switch controlling residues; other site 1206105007606 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206105007607 D-galactonate transporter; Region: 2A0114; TIGR00893 1206105007608 putative substrate translocation pore; other site 1206105007609 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1206105007610 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1206105007611 catalytic residue [active] 1206105007612 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1206105007613 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1206105007614 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1206105007615 putative allantoin catabolism protein; Region: ura-cupin; TIGR03214 1206105007616 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 1206105007617 Cupin domain; Region: Cupin_2; cl17218 1206105007618 allantoate amidohydrolase; Region: AllC; TIGR03176 1206105007619 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1206105007620 active site 1206105007621 metal binding site [ion binding]; metal-binding site 1206105007622 dimer interface [polypeptide binding]; other site 1206105007623 allantoinase; Provisional; Region: PRK08044 1206105007624 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 1206105007625 active site 1206105007626 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 1206105007627 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1206105007628 Na binding site [ion binding]; other site 1206105007629 putative substrate binding site [chemical binding]; other site 1206105007630 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1206105007631 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1206105007632 Coenzyme A binding pocket [chemical binding]; other site 1206105007633 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1206105007634 MarR family; Region: MarR; pfam01047 1206105007635 MarR family; Region: MarR_2; cl17246 1206105007636 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1206105007637 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1206105007638 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1206105007639 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1206105007640 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1206105007641 active site 1206105007642 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49); Region: G6PD_bact; pfam10786 1206105007643 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 1206105007644 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1206105007645 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1206105007646 ATP binding site [chemical binding]; other site 1206105007647 putative Mg++ binding site [ion binding]; other site 1206105007648 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 1206105007649 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1206105007650 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1206105007651 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1206105007652 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1206105007653 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1206105007654 Int/Topo IB signature motif; other site 1206105007655 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1206105007656 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1206105007657 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1206105007658 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1206105007659 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1206105007660 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1206105007661 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1206105007662 DRTGG domain; Region: DRTGG; pfam07085 1206105007663 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1206105007664 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1206105007665 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 1206105007666 CoA binding domain; Region: CoA_binding; pfam02629 1206105007667 CoA-ligase; Region: Ligase_CoA; pfam00549 1206105007668 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 1206105007669 Mga helix-turn-helix domain; Region: Mga; pfam05043 1206105007670 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1206105007671 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1206105007672 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1206105007673 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1206105007674 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1206105007675 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1206105007676 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1206105007677 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1206105007678 serine/threonine transporter SstT; Provisional; Region: PRK13628 1206105007679 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1206105007680 Ion channel; Region: Ion_trans_2; pfam07885 1206105007681 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1206105007682 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1206105007683 dimerization interface 3.5A [polypeptide binding]; other site 1206105007684 active site 1206105007685 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 1206105007686 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 1206105007687 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1206105007688 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1206105007689 DNA binding residues [nucleotide binding] 1206105007690 DinB superfamily; Region: DinB_2; pfam12867 1206105007691 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1206105007692 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1206105007693 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1206105007694 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 1206105007695 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 1206105007696 substrate binding site [chemical binding]; other site 1206105007697 catalytic residues [active] 1206105007698 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1206105007699 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1206105007700 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1206105007701 protein binding site [polypeptide binding]; other site 1206105007702 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1206105007703 putative tRNA-binding site [nucleotide binding]; other site 1206105007704 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 1206105007705 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 1206105007706 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1206105007707 active site 1206105007708 phosphorylation site [posttranslational modification] 1206105007709 BtpA family; Region: BtpA; cl00440 1206105007710 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1206105007711 active pocket/dimerization site; other site 1206105007712 active site 1206105007713 phosphorylation site [posttranslational modification] 1206105007714 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1206105007715 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1206105007716 DNA-binding site [nucleotide binding]; DNA binding site 1206105007717 UTRA domain; Region: UTRA; pfam07702 1206105007718 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1206105007719 Ligand Binding Site [chemical binding]; other site 1206105007720 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1206105007721 catalytic residues [active] 1206105007722 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1206105007723 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1206105007724 oligomer interface [polypeptide binding]; other site 1206105007725 active site 1206105007726 metal binding site [ion binding]; metal-binding site 1206105007727 Predicted small secreted protein [Function unknown]; Region: COG5584 1206105007728 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1206105007729 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1206105007730 peptide binding site [polypeptide binding]; other site 1206105007731 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 1206105007732 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 1206105007733 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1206105007734 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1206105007735 active site 1206105007736 dimer interface [polypeptide binding]; other site 1206105007737 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1206105007738 active site 1206105007739 phosphorylation site [posttranslational modification] 1206105007740 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1206105007741 active pocket/dimerization site; other site 1206105007742 active site 1206105007743 phosphorylation site [posttranslational modification] 1206105007744 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1206105007745 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 1206105007746 putative active site [active] 1206105007747 YdjC motif; other site 1206105007748 Mg binding site [ion binding]; other site 1206105007749 putative homodimer interface [polypeptide binding]; other site 1206105007750 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1206105007751 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1206105007752 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1206105007753 putative active site [active] 1206105007754 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1206105007755 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1206105007756 putative active site [active] 1206105007757 putative proton-coupled thiamine transporter YuaJ; Region: thia_yuaJ; TIGR02357 1206105007758 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1206105007759 Predicted membrane protein [Function unknown]; Region: COG3212 1206105007760 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1206105007761 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 1206105007762 active site 1206105007763 catalytic site [active] 1206105007764 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1206105007765 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1206105007766 active site 1206105007767 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1206105007768 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206105007769 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1206105007770 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 1206105007771 rod shape-determining protein MreC; Provisional; Region: PRK13922 1206105007772 rod shape-determining protein MreC; Region: MreC; pfam04085 1206105007773 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1206105007774 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1206105007775 RNase E interface [polypeptide binding]; other site 1206105007776 trimer interface [polypeptide binding]; other site 1206105007777 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1206105007778 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1206105007779 RNase E interface [polypeptide binding]; other site 1206105007780 trimer interface [polypeptide binding]; other site 1206105007781 active site 1206105007782 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1206105007783 putative nucleic acid binding region [nucleotide binding]; other site 1206105007784 G-X-X-G motif; other site 1206105007785 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1206105007786 RNA binding site [nucleotide binding]; other site 1206105007787 domain interface; other site 1206105007788 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1206105007789 16S/18S rRNA binding site [nucleotide binding]; other site 1206105007790 25S rRNA binding site [nucleotide binding]; other site 1206105007791 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1206105007792 active site 1206105007793 catalytic residues [active] 1206105007794 metal binding site [ion binding]; metal-binding site 1206105007795 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1206105007796 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1206105007797 active site 1206105007798 motif I; other site 1206105007799 motif II; other site 1206105007800 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1206105007801 active site 1206105007802 motif I; other site 1206105007803 motif II; other site 1206105007804 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1206105007805 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 1206105007806 active site 1206105007807 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 1206105007808 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1206105007809 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1206105007810 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1206105007811 RNA binding surface [nucleotide binding]; other site 1206105007812 BioY family; Region: BioY; pfam02632 1206105007813 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1206105007814 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 1206105007815 Catalytic site [active] 1206105007816 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1206105007817 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 1206105007818 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 1206105007819 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1206105007820 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1206105007821 peptidase T; Region: peptidase-T; TIGR01882 1206105007822 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1206105007823 metal binding site [ion binding]; metal-binding site 1206105007824 dimer interface [polypeptide binding]; other site 1206105007825 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1206105007826 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1206105007827 peptide binding site [polypeptide binding]; other site 1206105007828 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1206105007829 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1206105007830 putative ligand binding residues [chemical binding]; other site 1206105007831 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1206105007832 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1206105007833 Walker A/P-loop; other site 1206105007834 ATP binding site [chemical binding]; other site 1206105007835 Q-loop/lid; other site 1206105007836 ABC transporter signature motif; other site 1206105007837 Walker B; other site 1206105007838 D-loop; other site 1206105007839 H-loop/switch region; other site 1206105007840 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1206105007841 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1206105007842 ABC-ATPase subunit interface; other site 1206105007843 dimer interface [polypeptide binding]; other site 1206105007844 putative PBP binding regions; other site 1206105007845 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1206105007846 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1206105007847 ABC-ATPase subunit interface; other site 1206105007848 dimer interface [polypeptide binding]; other site 1206105007849 putative PBP binding regions; other site 1206105007850 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 1206105007851 glutamate--cysteine ligase/gamma-glutamylcysteine synthetase, Streptococcus agalactiae type; Region: glu_cys_lig_rel; TIGR01435 1206105007852 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 1206105007853 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1206105007854 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1206105007855 Isochorismatase family; Region: Isochorismatase; pfam00857 1206105007856 catalytic triad [active] 1206105007857 conserved cis-peptide bond; other site 1206105007858 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1206105007859 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1206105007860 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1206105007861 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1206105007862 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1206105007863 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 1206105007864 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1206105007865 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1206105007866 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1206105007867 P loop; other site 1206105007868 GTP binding site [chemical binding]; other site 1206105007869 sugar phosphate phosphatase; Provisional; Region: PRK10513 1206105007870 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1206105007871 active site 1206105007872 motif I; other site 1206105007873 motif II; other site 1206105007874 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1206105007875 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1206105007876 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1206105007877 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1206105007878 ABC transporter signature motif; other site 1206105007879 Walker B; other site 1206105007880 D-loop; other site 1206105007881 H-loop/switch region; other site 1206105007882 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1206105007883 AAA domain; Region: AAA_23; pfam13476 1206105007884 Walker A/P-loop; other site 1206105007885 ATP binding site [chemical binding]; other site 1206105007886 Q-loop/lid; other site 1206105007887 ribonuclease III; Reviewed; Region: rnc; PRK00102 1206105007888 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1206105007889 dimerization interface [polypeptide binding]; other site 1206105007890 active site 1206105007891 metal binding site [ion binding]; metal-binding site 1206105007892 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1206105007893 dsRNA binding site [nucleotide binding]; other site 1206105007894 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 1206105007895 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1206105007896 peptide binding site [polypeptide binding]; other site 1206105007897 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171 1206105007898 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206105007899 dimer interface [polypeptide binding]; other site 1206105007900 conserved gate region; other site 1206105007901 putative PBP binding loops; other site 1206105007902 ABC-ATPase subunit interface; other site 1206105007903 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1206105007904 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206105007905 dimer interface [polypeptide binding]; other site 1206105007906 conserved gate region; other site 1206105007907 putative PBP binding loops; other site 1206105007908 ABC-ATPase subunit interface; other site 1206105007909 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1206105007910 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1206105007911 Walker A/P-loop; other site 1206105007912 ATP binding site [chemical binding]; other site 1206105007913 Q-loop/lid; other site 1206105007914 ABC transporter signature motif; other site 1206105007915 Walker B; other site 1206105007916 D-loop; other site 1206105007917 H-loop/switch region; other site 1206105007918 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1206105007919 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1206105007920 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1206105007921 Walker A/P-loop; other site 1206105007922 ATP binding site [chemical binding]; other site 1206105007923 Q-loop/lid; other site 1206105007924 ABC transporter signature motif; other site 1206105007925 Walker B; other site 1206105007926 D-loop; other site 1206105007927 H-loop/switch region; other site 1206105007928 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1206105007929 acyl carrier protein; Provisional; Region: acpP; PRK00982 1206105007930 putative phosphate acyltransferase; Provisional; Region: PRK05331 1206105007931 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1206105007932 Y-family of DNA polymerases; Region: PolY; cl12025 1206105007933 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1206105007934 generic binding surface II; other site 1206105007935 ssDNA binding site; other site 1206105007936 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1206105007937 ATP binding site [chemical binding]; other site 1206105007938 putative Mg++ binding site [ion binding]; other site 1206105007939 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1206105007940 nucleotide binding region [chemical binding]; other site 1206105007941 ATP-binding site [chemical binding]; other site 1206105007942 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1206105007943 DAK2 domain; Region: Dak2; pfam02734 1206105007944 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1206105007945 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1206105007946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1206105007947 active site 1206105007948 phosphorylation site [posttranslational modification] 1206105007949 intermolecular recognition site; other site 1206105007950 dimerization interface [polypeptide binding]; other site 1206105007951 LytTr DNA-binding domain; Region: LytTR; pfam04397 1206105007952 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1206105007953 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1206105007954 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1206105007955 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1206105007956 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206105007957 Walker A/P-loop; other site 1206105007958 ATP binding site [chemical binding]; other site 1206105007959 Q-loop/lid; other site 1206105007960 ABC transporter signature motif; other site 1206105007961 Walker B; other site 1206105007962 D-loop; other site 1206105007963 H-loop/switch region; other site 1206105007964 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1206105007965 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1206105007966 Thiamine pyrophosphokinase; Region: TPK; cd07995 1206105007967 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 1206105007968 active site 1206105007969 dimerization interface [polypeptide binding]; other site 1206105007970 thiamine binding site [chemical binding]; other site 1206105007971 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1206105007972 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1206105007973 substrate binding site [chemical binding]; other site 1206105007974 hexamer interface [polypeptide binding]; other site 1206105007975 metal binding site [ion binding]; metal-binding site 1206105007976 GTPase RsgA; Reviewed; Region: PRK00098 1206105007977 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1206105007978 RNA binding site [nucleotide binding]; other site 1206105007979 homodimer interface [polypeptide binding]; other site 1206105007980 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1206105007981 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1206105007982 GTP/Mg2+ binding site [chemical binding]; other site 1206105007983 G4 box; other site 1206105007984 G5 box; other site 1206105007985 G1 box; other site 1206105007986 Switch I region; other site 1206105007987 G2 box; other site 1206105007988 G3 box; other site 1206105007989 Switch II region; other site 1206105007990 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1206105007991 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1206105007992 active site 1206105007993 ATP binding site [chemical binding]; other site 1206105007994 substrate binding site [chemical binding]; other site 1206105007995 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1206105007996 substrate binding site [chemical binding]; other site 1206105007997 activation loop (A-loop); other site 1206105007998 activation loop (A-loop); other site 1206105007999 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1206105008000 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1206105008001 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1206105008002 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1206105008003 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1206105008004 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1206105008005 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1206105008006 active site 1206105008007 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1206105008008 NusB family; Region: NusB; pfam01029 1206105008009 putative RNA binding site [nucleotide binding]; other site 1206105008010 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206105008011 S-adenosylmethionine binding site [chemical binding]; other site 1206105008012 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1206105008013 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1206105008014 putative active site [active] 1206105008015 substrate binding site [chemical binding]; other site 1206105008016 putative cosubstrate binding site; other site 1206105008017 catalytic site [active] 1206105008018 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1206105008019 substrate binding site [chemical binding]; other site 1206105008020 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1206105008021 active site 1206105008022 catalytic residues [active] 1206105008023 metal binding site [ion binding]; metal-binding site 1206105008024 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1206105008025 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1206105008026 ATP binding site [chemical binding]; other site 1206105008027 putative Mg++ binding site [ion binding]; other site 1206105008028 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1206105008029 nucleotide binding region [chemical binding]; other site 1206105008030 ATP-binding site [chemical binding]; other site 1206105008031 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1206105008032 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1206105008033 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1206105008034 catalytic site [active] 1206105008035 G-X2-G-X-G-K; other site 1206105008036 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1206105008037 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1206105008038 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 1206105008039 acyl-CoA esterase; Provisional; Region: PRK10673 1206105008040 hypothetical protein; Provisional; Region: PRK11820 1206105008041 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1206105008042 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1206105008043 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 1206105008044 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 1206105008045 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 1206105008046 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1206105008047 active site 1206105008048 intersubunit interface [polypeptide binding]; other site 1206105008049 catalytic residue [active] 1206105008050 mannonate dehydratase; Provisional; Region: PRK03906 1206105008051 mannonate dehydratase; Region: uxuA; TIGR00695 1206105008052 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1206105008053 active pocket/dimerization site; other site 1206105008054 active site 1206105008055 phosphorylation site [posttranslational modification] 1206105008056 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 1206105008057 active site 1206105008058 phosphorylation site [posttranslational modification] 1206105008059 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 1206105008060 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 1206105008061 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1206105008062 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 1206105008063 putative active site [active] 1206105008064 metal binding site [ion binding]; metal-binding site 1206105008065 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1206105008066 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_12; cd12177 1206105008067 putative ligand binding site [chemical binding]; other site 1206105008068 putative NAD binding site [chemical binding]; other site 1206105008069 catalytic site [active] 1206105008070 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 1206105008071 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1206105008072 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1206105008073 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1206105008074 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1206105008075 putative active site [active] 1206105008076 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 1206105008077 LXG domain of WXG superfamily; Region: LXG; pfam04740 1206105008078 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1206105008079 Helix-turn-helix domain; Region: HTH_25; pfam13413 1206105008080 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1206105008081 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1206105008082 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1206105008083 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1206105008084 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1206105008085 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1206105008086 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1206105008087 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1206105008088 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1206105008089 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1206105008090 DNA-binding site [nucleotide binding]; DNA binding site 1206105008091 UTRA domain; Region: UTRA; pfam07702 1206105008092 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1206105008093 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1206105008094 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1206105008095 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1206105008096 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1206105008097 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1206105008098 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1206105008099 motif II; other site 1206105008100 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1206105008101 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1206105008102 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1206105008103 active site 1206105008104 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1206105008105 SelR domain; Region: SelR; pfam01641 1206105008106 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1206105008107 active site 1206105008108 dimer interface [polypeptide binding]; other site 1206105008109 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 1206105008110 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1206105008111 ATP binding site [chemical binding]; other site 1206105008112 Mg2+ binding site [ion binding]; other site 1206105008113 G-X-G motif; other site 1206105008114 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1206105008115 ATP binding site [chemical binding]; other site 1206105008116 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1206105008117 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1206105008118 MutS domain I; Region: MutS_I; pfam01624 1206105008119 MutS domain II; Region: MutS_II; pfam05188 1206105008120 MutS domain III; Region: MutS_III; pfam05192 1206105008121 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1206105008122 Walker A/P-loop; other site 1206105008123 ATP binding site [chemical binding]; other site 1206105008124 Q-loop/lid; other site 1206105008125 ABC transporter signature motif; other site 1206105008126 Walker B; other site 1206105008127 D-loop; other site 1206105008128 H-loop/switch region; other site 1206105008129 Protein of unknown function (DUF964); Region: DUF964; cl01483 1206105008130 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1206105008131 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1206105008132 putative active site [active] 1206105008133 metal binding site [ion binding]; metal-binding site 1206105008134 homodimer binding site [polypeptide binding]; other site 1206105008135 phosphodiesterase; Provisional; Region: PRK12704 1206105008136 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1206105008137 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1206105008138 Zn2+ binding site [ion binding]; other site 1206105008139 Mg2+ binding site [ion binding]; other site 1206105008140 recombinase A; Provisional; Region: recA; PRK09354 1206105008141 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1206105008142 hexamer interface [polypeptide binding]; other site 1206105008143 Walker A motif; other site 1206105008144 ATP binding site [chemical binding]; other site 1206105008145 Walker B motif; other site 1206105008146 competence damage-inducible protein A; Provisional; Region: PRK00549 1206105008147 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1206105008148 putative MPT binding site; other site 1206105008149 Competence-damaged protein; Region: CinA; pfam02464 1206105008150 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1206105008151 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1206105008152 NAD binding site [chemical binding]; other site 1206105008153 substrate binding site [chemical binding]; other site 1206105008154 putative active site [active] 1206105008155 Predicted transcriptional regulator [Transcription]; Region: COG1959 1206105008156 Transcriptional regulator; Region: Rrf2; pfam02082 1206105008157 hypothetical protein; Provisional; Region: PRK11770 1206105008158 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1206105008159 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 1206105008160 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1206105008161 metal binding site [ion binding]; metal-binding site 1206105008162 dimer interface [polypeptide binding]; other site 1206105008163 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1206105008164 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1206105008165 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1206105008166 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1206105008167 DNA binding residues [nucleotide binding] 1206105008168 Mga helix-turn-helix domain; Region: Mga; pfam05043 1206105008169 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1206105008170 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 1206105008171 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1206105008172 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1206105008173 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1206105008174 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1206105008175 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1206105008176 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1206105008177 Isochorismatase family; Region: Isochorismatase; pfam00857 1206105008178 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1206105008179 catalytic triad [active] 1206105008180 conserved cis-peptide bond; other site 1206105008181 antiholin-like protein LrgB; Provisional; Region: PRK04288 1206105008182 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 1206105008183 two-component response regulator; Provisional; Region: PRK14084 1206105008184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1206105008185 active site 1206105008186 phosphorylation site [posttranslational modification] 1206105008187 intermolecular recognition site; other site 1206105008188 dimerization interface [polypeptide binding]; other site 1206105008189 LytTr DNA-binding domain; Region: LytTR; pfam04397 1206105008190 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1206105008191 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1206105008192 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1206105008193 Histidine kinase; Region: His_kinase; pfam06580 1206105008194 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1206105008195 ATP binding site [chemical binding]; other site 1206105008196 Mg2+ binding site [ion binding]; other site 1206105008197 G-X-G motif; other site 1206105008198 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1206105008199 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1206105008200 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 1206105008201 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1206105008202 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1206105008203 Walker A/P-loop; other site 1206105008204 ATP binding site [chemical binding]; other site 1206105008205 Q-loop/lid; other site 1206105008206 ABC transporter signature motif; other site 1206105008207 Walker B; other site 1206105008208 D-loop; other site 1206105008209 H-loop/switch region; other site 1206105008210 OsmC-like protein; Region: OsmC; pfam02566 1206105008211 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1206105008212 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1206105008213 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1206105008214 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1206105008215 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1206105008216 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1206105008217 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1206105008218 metal binding site [ion binding]; metal-binding site 1206105008219 YodA lipocalin-like domain; Region: YodA; pfam09223 1206105008220 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1206105008221 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1206105008222 FMN binding site [chemical binding]; other site 1206105008223 active site 1206105008224 catalytic residues [active] 1206105008225 substrate binding site [chemical binding]; other site 1206105008226 inner membrane transport permease; Provisional; Region: PRK15066 1206105008227 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1206105008228 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1206105008229 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 1206105008230 Walker A/P-loop; other site 1206105008231 ATP binding site [chemical binding]; other site 1206105008232 Q-loop/lid; other site 1206105008233 ABC transporter signature motif; other site 1206105008234 Walker B; other site 1206105008235 D-loop; other site 1206105008236 H-loop/switch region; other site 1206105008237 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1206105008238 active pocket/dimerization site; other site 1206105008239 active site 1206105008240 phosphorylation site [posttranslational modification] 1206105008241 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 1206105008242 active site 1206105008243 phosphorylation site [posttranslational modification] 1206105008244 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 1206105008245 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1206105008246 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206105008247 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1206105008248 Walker A motif; other site 1206105008249 ATP binding site [chemical binding]; other site 1206105008250 Walker B motif; other site 1206105008251 arginine finger; other site 1206105008252 Transcriptional antiterminator [Transcription]; Region: COG3933 1206105008253 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1206105008254 active pocket/dimerization site; other site 1206105008255 active site 1206105008256 phosphorylation site [posttranslational modification] 1206105008257 PRD domain; Region: PRD; pfam00874 1206105008258 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1206105008259 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1206105008260 Sulfatase; Region: Sulfatase; cl17466 1206105008261 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1206105008262 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1206105008263 23S rRNA interface [nucleotide binding]; other site 1206105008264 L3 interface [polypeptide binding]; other site 1206105008265 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1206105008266 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1206105008267 dimerization interface [polypeptide binding]; other site 1206105008268 DPS ferroxidase diiron center [ion binding]; other site 1206105008269 ion pore; other site 1206105008270 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1206105008271 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1206105008272 N- and C-terminal domain interface [polypeptide binding]; other site 1206105008273 active site 1206105008274 catalytic site [active] 1206105008275 metal binding site [ion binding]; metal-binding site 1206105008276 carbohydrate binding site [chemical binding]; other site 1206105008277 ATP binding site [chemical binding]; other site 1206105008278 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1206105008279 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1206105008280 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1206105008281 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1206105008282 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1206105008283 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1206105008284 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1206105008285 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1206105008286 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1206105008287 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1206105008288 DNA binding site [nucleotide binding] 1206105008289 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1206105008290 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1206105008291 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1206105008292 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1206105008293 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1206105008294 RPB1 interaction site [polypeptide binding]; other site 1206105008295 RPB10 interaction site [polypeptide binding]; other site 1206105008296 RPB11 interaction site [polypeptide binding]; other site 1206105008297 RPB3 interaction site [polypeptide binding]; other site 1206105008298 RPB12 interaction site [polypeptide binding]; other site 1206105008299 PemK-like protein; Region: PemK; pfam02452 1206105008300 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855 1206105008301 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1206105008302 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1206105008303 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1206105008304 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1206105008305 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1206105008306 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1206105008307 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1206105008308 active site 1206105008309 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1206105008310 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1206105008311 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1206105008312 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1206105008313 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 1206105008314 UbiA prenyltransferase family; Region: UbiA; pfam01040 1206105008315 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1206105008316 ApbE family; Region: ApbE; pfam02424 1206105008317 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 1206105008318 FMN-binding domain; Region: FMN_bind; pfam04205 1206105008319 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1206105008320 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1206105008321 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 1206105008322 trimer interface [polypeptide binding]; other site 1206105008323 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 1206105008324 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1206105008325 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1206105008326 substrate binding pocket [chemical binding]; other site 1206105008327 chain length determination region; other site 1206105008328 substrate-Mg2+ binding site; other site 1206105008329 catalytic residues [active] 1206105008330 aspartate-rich region 1; other site 1206105008331 active site lid residues [active] 1206105008332 aspartate-rich region 2; other site 1206105008333 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1206105008334 PemK-like protein; Region: PemK; pfam02452 1206105008335 dihydropteroate synthase; Region: DHPS; TIGR01496 1206105008336 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1206105008337 substrate binding pocket [chemical binding]; other site 1206105008338 dimer interface [polypeptide binding]; other site 1206105008339 inhibitor binding site; inhibition site 1206105008340 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1206105008341 active site 1206105008342 dimerization interface [polypeptide binding]; other site 1206105008343 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 1206105008344 GTP cyclohydrolase I; Provisional; Region: PLN03044 1206105008345 active site 1206105008346 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1206105008347 catalytic center binding site [active] 1206105008348 ATP binding site [chemical binding]; other site 1206105008349 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1206105008350 homooctamer interface [polypeptide binding]; other site 1206105008351 active site 1206105008352 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1206105008353 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1206105008354 non-specific DNA binding site [nucleotide binding]; other site 1206105008355 salt bridge; other site 1206105008356 sequence-specific DNA binding site [nucleotide binding]; other site 1206105008357 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 1206105008358 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206105008359 AAA domain; Region: AAA_18; pfam13238 1206105008360 Walker A motif; other site 1206105008361 ATP binding site [chemical binding]; other site 1206105008362 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1206105008363 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1206105008364 non-specific DNA binding site [nucleotide binding]; other site 1206105008365 salt bridge; other site 1206105008366 sequence-specific DNA binding site [nucleotide binding]; other site 1206105008367 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 1206105008368 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1206105008369 Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770 1206105008370 putative catalytic residues [active] 1206105008371 catalytic nucleophile [active] 1206105008372 Recombinase; Region: Recombinase; pfam07508 1206105008373 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1206105008374 Domain of unknown function (DUF4368); Region: DUF4368; pfam14287 1206105008375 glutathione-disulfide reductase, animal/bacterial; Region: gluta_reduc_1; TIGR01421 1206105008376 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1206105008377 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1206105008378 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1206105008379 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1206105008380 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1206105008381 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1206105008382 Uncharacterized conserved protein [Function unknown]; Region: COG3535 1206105008383 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 1206105008384 Na binding site [ion binding]; other site 1206105008385 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1206105008386 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1206105008387 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1206105008388 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1206105008389 Peptidase family U32; Region: Peptidase_U32; pfam01136 1206105008390 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1206105008391 Peptidase family U32; Region: Peptidase_U32; pfam01136 1206105008392 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1206105008393 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1206105008394 Clp amino terminal domain; Region: Clp_N; pfam02861 1206105008395 Clp amino terminal domain; Region: Clp_N; pfam02861 1206105008396 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206105008397 Walker A motif; other site 1206105008398 ATP binding site [chemical binding]; other site 1206105008399 Walker B motif; other site 1206105008400 arginine finger; other site 1206105008401 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206105008402 Walker A motif; other site 1206105008403 ATP binding site [chemical binding]; other site 1206105008404 Walker B motif; other site 1206105008405 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1206105008406 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 1206105008407 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1206105008408 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1206105008409 homodimer interface [polypeptide binding]; other site 1206105008410 substrate-cofactor binding pocket; other site 1206105008411 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206105008412 catalytic residue [active] 1206105008413 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1206105008414 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1206105008415 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1206105008416 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1206105008417 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1206105008418 putative active site [active] 1206105008419 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1206105008420 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1206105008421 active site 1206105008422 phosphorylation site [posttranslational modification] 1206105008423 intermolecular recognition site; other site 1206105008424 dimerization interface [polypeptide binding]; other site 1206105008425 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1206105008426 DNA binding site [nucleotide binding] 1206105008427 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1206105008428 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1206105008429 dimer interface [polypeptide binding]; other site 1206105008430 phosphorylation site [posttranslational modification] 1206105008431 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1206105008432 ATP binding site [chemical binding]; other site 1206105008433 Mg2+ binding site [ion binding]; other site 1206105008434 G-X-G motif; other site 1206105008435 seryl-tRNA synthetase; Provisional; Region: PRK05431 1206105008436 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1206105008437 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1206105008438 dimer interface [polypeptide binding]; other site 1206105008439 active site 1206105008440 motif 1; other site 1206105008441 motif 2; other site 1206105008442 motif 3; other site 1206105008443 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1206105008444 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1206105008445 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1206105008446 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1206105008447 active site 1206105008448 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 1206105008449 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 1206105008450 GTP-binding protein YchF; Reviewed; Region: PRK09601 1206105008451 YchF GTPase; Region: YchF; cd01900 1206105008452 G1 box; other site 1206105008453 GTP/Mg2+ binding site [chemical binding]; other site 1206105008454 Switch I region; other site 1206105008455 G2 box; other site 1206105008456 Switch II region; other site 1206105008457 G3 box; other site 1206105008458 G4 box; other site 1206105008459 G5 box; other site 1206105008460 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1206105008461 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1206105008462 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1206105008463 ParB-like nuclease domain; Region: ParBc; pfam02195 1206105008464 KorB domain; Region: KorB; pfam08535 1206105008465 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1206105008466 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1206105008467 P-loop; other site 1206105008468 Magnesium ion binding site [ion binding]; other site 1206105008469 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1206105008470 Magnesium ion binding site [ion binding]; other site 1206105008471 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1206105008472 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1206105008473 Protein of unknown function (DUF3114); Region: DUF3114; pfam11311 1206105008474 myosin-cross-reactive antigen; Provisional; Region: PRK13977 1206105008475 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1206105008476 active site 1206105008477 intersubunit interactions; other site 1206105008478 catalytic residue [active] 1206105008479 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 1206105008480 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 1206105008481 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 1206105008482 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 1206105008483 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 1206105008484 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 1206105008485 HTH domain; Region: HTH_11; pfam08279 1206105008486 HTH domain; Region: HTH_11; pfam08279 1206105008487 PRD domain; Region: PRD; pfam00874 1206105008488 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1206105008489 active site 1206105008490 P-loop; other site 1206105008491 phosphorylation site [posttranslational modification] 1206105008492 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 1206105008493 active site 1206105008494 phosphorylation site [posttranslational modification] 1206105008495 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 1206105008496 classical (c) SDRs; Region: SDR_c; cd05233 1206105008497 NAD(P) binding site [chemical binding]; other site 1206105008498 active site 1206105008499 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1206105008500 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1206105008501 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1206105008502 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1206105008503 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1206105008504 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1206105008505 G1 box; other site 1206105008506 GTP/Mg2+ binding site [chemical binding]; other site 1206105008507 Switch I region; other site 1206105008508 G2 box; other site 1206105008509 Switch II region; other site 1206105008510 G3 box; other site 1206105008511 G4 box; other site 1206105008512 G5 box; other site 1206105008513 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1206105008514 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 1206105008515 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1206105008516 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1206105008517 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 1206105008518 NAD(P) binding pocket [chemical binding]; other site 1206105008519 oxaloacetate decarboxylase; Provisional; Region: PRK12331 1206105008520 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1206105008521 active site 1206105008522 catalytic residues [active] 1206105008523 metal binding site [ion binding]; metal-binding site 1206105008524 homodimer binding site [polypeptide binding]; other site 1206105008525 2'-(5''-triphosphoribosyl)-3'- dephospho-CoA:apo-citrate lyase; Reviewed; Region: citX; PRK01392 1206105008526 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 1206105008527 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1206105008528 citrate lyase subunit gamma; Provisional; Region: PRK13253 1206105008529 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 1206105008530 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 1206105008531 putative active site [active] 1206105008532 (T/H)XGH motif; other site 1206105008533 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; pfam03977 1206105008534 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549 1206105008535 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1206105008536 carboxyltransferase (CT) interaction site; other site 1206105008537 biotinylation site [posttranslational modification]; other site 1206105008538 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1206105008539 Citrate transporter; Region: CitMHS; pfam03600 1206105008540 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1206105008541 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1206105008542 DNA-binding site [nucleotide binding]; DNA binding site 1206105008543 FCD domain; Region: FCD; pfam07729 1206105008544 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1206105008545 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1206105008546 active site 1206105008547 phosphorylation site [posttranslational modification] 1206105008548 intermolecular recognition site; other site 1206105008549 dimerization interface [polypeptide binding]; other site 1206105008550 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1206105008551 DNA binding site [nucleotide binding] 1206105008552 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1206105008553 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1206105008554 catalytic residues [active] 1206105008555 catalytic nucleophile [active] 1206105008556 Presynaptic Site I dimer interface [polypeptide binding]; other site 1206105008557 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1206105008558 Synaptic Flat tetramer interface [polypeptide binding]; other site 1206105008559 Synaptic Site I dimer interface [polypeptide binding]; other site 1206105008560 DNA binding site [nucleotide binding] 1206105008561 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1206105008562 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 1206105008563 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 1206105008564 Domain of unknown function DUF87; Region: DUF87; pfam01935 1206105008565 AAA-like domain; Region: AAA_10; pfam12846 1206105008566 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 1206105008567 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1206105008568 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1206105008569 G-X-X-G motif; other site 1206105008570 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1206105008571 RxxxH motif; other site 1206105008572 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1206105008573 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1206105008574 ribonuclease P; Reviewed; Region: rnpA; PRK00499 1206105008575 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1206105008576 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 1206105008577 Transcriptional regulator; Region: Rrf2; cl17282 1206105008578 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1206105008579 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1206105008580 catalytic residues [active] 1206105008581 catalytic nucleophile [active] 1206105008582 Presynaptic Site I dimer interface [polypeptide binding]; other site 1206105008583 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1206105008584 Synaptic Flat tetramer interface [polypeptide binding]; other site 1206105008585 Synaptic Site I dimer interface [polypeptide binding]; other site 1206105008586 DNA binding site [nucleotide binding] 1206105008587 DNA topoisomerase III; Provisional; Region: PRK07726 1206105008588 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1206105008589 active site 1206105008590 putative interdomain interaction site [polypeptide binding]; other site 1206105008591 putative metal-binding site [ion binding]; other site 1206105008592 putative nucleotide binding site [chemical binding]; other site 1206105008593 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1206105008594 domain I; other site 1206105008595 DNA binding groove [nucleotide binding] 1206105008596 phosphate binding site [ion binding]; other site 1206105008597 domain II; other site 1206105008598 domain III; other site 1206105008599 nucleotide binding site [chemical binding]; other site 1206105008600 catalytic site [active] 1206105008601 domain IV; other site 1206105008602 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1206105008603 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 1206105008604 Omega Transcriptional Repressor; Region: Omega_Repress; pfam07764 1206105008605 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 1206105008606 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206105008607 S-adenosylmethionine binding site [chemical binding]; other site 1206105008608 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 1206105008609 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1206105008610 P-loop; other site 1206105008611 Magnesium ion binding site [ion binding]; other site 1206105008612 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1206105008613 Magnesium ion binding site [ion binding]; other site 1206105008614 Omega Transcriptional Repressor; Region: Omega_Repress; pfam07764 1206105008615 Bacterial epsilon antitoxin; Region: Epsilon_antitox; pfam08998 1206105008616 Zeta toxin; Region: Zeta_toxin; pfam06414 1206105008617 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1206105008618 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1206105008619 Integrase core domain; Region: rve; pfam00665 1206105008620 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206105008621 Walker A/P-loop; other site 1206105008622 ATP binding site [chemical binding]; other site 1206105008623 ABC transporter; Region: ABC_tran; pfam00005 1206105008624 Q-loop/lid; other site 1206105008625 ABC transporter signature motif; other site 1206105008626 Walker B; other site 1206105008627 D-loop; other site 1206105008628 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1206105008629 non-specific DNA binding site [nucleotide binding]; other site 1206105008630 salt bridge; other site 1206105008631 sequence-specific DNA binding site [nucleotide binding]; other site 1206105008632 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 1206105008633 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1206105008634 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1206105008635 peptide binding site [polypeptide binding]; other site 1206105008636 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1206105008637 non-specific DNA binding site [nucleotide binding]; other site 1206105008638 salt bridge; other site 1206105008639 sequence-specific DNA binding site [nucleotide binding]; other site 1206105008640 Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354 1206105008641 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 1206105008642 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1206105008643 Cna protein B-type domain; Region: Cna_B; pfam05738 1206105008644 Cna protein B-type domain; Region: Cna_B; pfam05738 1206105008645 Cna protein B-type domain; Region: Cna_B; pfam05738 1206105008646 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1206105008647 CHAP domain; Region: CHAP; pfam05257 1206105008648 DEAD-like helicases superfamily; Region: DEXDc2; smart00488 1206105008649 TIR domain; Region: TIR_2; pfam13676 1206105008650 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 1206105008651 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1206105008652 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 1206105008653 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 1206105008654 Cytochrome B561, N terminal; Region: CytochromB561_N; pfam09786 1206105008655 AAA-like domain; Region: AAA_10; pfam12846 1206105008656 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1206105008657 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1206105008658 catalytic residue [active] 1206105008659 CHAP domain; Region: CHAP; cl17642 1206105008660 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 1206105008661 Toprim-like; Region: Toprim_2; pfam13155 1206105008662 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1206105008663 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1206105008664 dimer interface [polypeptide binding]; other site 1206105008665 ssDNA binding site [nucleotide binding]; other site 1206105008666 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1206105008667 Staphylococcal nuclease homologues; Region: SNc; smart00318 1206105008668 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1206105008669 Catalytic site; other site 1206105008670 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1206105008671 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 1206105008672 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1206105008673 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 1206105008674 cofactor binding site; other site 1206105008675 DNA binding site [nucleotide binding] 1206105008676 substrate interaction site [chemical binding]; other site 1206105008677 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1206105008678 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1206105008679 DNA methylase; Region: N6_N4_Mtase; pfam01555 1206105008680 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1206105008681 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1206105008682 catalytic residues [active] 1206105008683 catalytic nucleophile [active] 1206105008684 Presynaptic Site I dimer interface [polypeptide binding]; other site 1206105008685 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1206105008686 Synaptic Flat tetramer interface [polypeptide binding]; other site 1206105008687 Synaptic Site I dimer interface [polypeptide binding]; other site 1206105008688 DNA binding site [nucleotide binding] 1206105008689 Preprotein translocase subunit; Region: YajC; cl00806 1206105008690 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1206105008691 Integrase core domain; Region: rve; pfam00665 1206105008692 transposase/IS protein; Provisional; Region: PRK09183 1206105008693 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206105008694 Walker A motif; other site 1206105008695 ATP binding site [chemical binding]; other site 1206105008696 Walker B motif; other site 1206105008697 arginine finger; other site 1206105008698 CAAX protease self-immunity; Region: Abi; pfam02517 1206105008699 DNA polymerase IV; Reviewed; Region: PRK03103 1206105008700 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1206105008701 active site 1206105008702 DNA binding site [nucleotide binding] 1206105008703 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1206105008704 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 1206105008705 P-loop; other site 1206105008706 Magnesium ion binding site [ion binding]; other site 1206105008707 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1206105008708 Magnesium ion binding site [ion binding]; other site