-- dump date 20140619_073652 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1166130000001 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1166130000002 Transposase; Region: HTH_Tnp_1; pfam01527 1166130000003 HTH-like domain; Region: HTH_21; pfam13276 1166130000004 Integrase core domain; Region: rve; pfam00665 1166130000005 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1166130000006 Integrase core domain; Region: rve_2; pfam13333 1166130000007 Plasmid stability protein; Region: Plasmid_stab_B; pfam10784 1166130000008 Plasmid stability protein; Region: Plasmid_stab_B; pfam10784 1166130000009 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 1166130000010 Mg binding site [ion binding]; other site 1166130000011 nucleotide binding site [chemical binding]; other site 1166130000012 putative protofilament interface [polypeptide binding]; other site 1166130000013 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1166130000014 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1166130000015 Catalytic site [active] 1166130000016 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1166130000017 DNA binding site [nucleotide binding] 1166130000018 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1166130000019 replication protein; Provisional; Region: PRK13742 1166130000020 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1166130000021 Magnesium ion binding site [ion binding]; other site 1166130000022 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1166130000023 active site 1166130000024 catalytic residues [active] 1166130000025 DNA binding site [nucleotide binding] 1166130000026 Int/Topo IB signature motif; other site 1166130000027 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1166130000028 Predicted transcriptional regulators [Transcription]; Region: COG1733 1166130000029 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1166130000030 dimerization interface [polypeptide binding]; other site 1166130000031 putative DNA binding site [nucleotide binding]; other site 1166130000032 putative Zn2+ binding site [ion binding]; other site 1166130000033 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1166130000034 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1166130000035 NAD binding site [chemical binding]; other site 1166130000036 substrate binding site [chemical binding]; other site 1166130000037 putative active site [active] 1166130000038 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 1166130000039 NmrA-like family; Region: NmrA; pfam05368 1166130000040 NADP binding site [chemical binding]; other site 1166130000041 active site 1166130000042 regulatory binding site [polypeptide binding]; other site 1166130000043 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166130000044 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130000045 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1166130000046 putative effector binding pocket; other site 1166130000047 dimerization interface [polypeptide binding]; other site 1166130000048 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1166130000049 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1166130000050 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130000051 Helix-turn-helix domain; Region: HTH_18; pfam12833 1166130000052 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130000053 argininosuccinate lyase; Provisional; Region: PRK06389 1166130000054 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1166130000055 Transposase; Region: HTH_Tnp_1; pfam01527 1166130000056 HTH-like domain; Region: HTH_21; pfam13276 1166130000057 Integrase core domain; Region: rve; pfam00665 1166130000058 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12870 1166130000059 UbiA prenyltransferase family; Region: UbiA; pfam01040 1166130000060 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1166130000061 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1166130000062 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1166130000063 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1166130000064 Transposase; Region: HTH_Tnp_1; pfam01527 1166130000065 putative transposase OrfB; Reviewed; Region: PHA02517 1166130000066 HTH-like domain; Region: HTH_21; pfam13276 1166130000067 Integrase core domain; Region: rve; pfam00665 1166130000068 Integrase core domain; Region: rve_2; pfam13333 1166130000069 PIN domain; Region: PIN_3; pfam13470 1166130000070 DNA binding domain, excisionase family; Region: excise; TIGR01764 1166130000071 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1166130000072 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1166130000073 Integrase core domain; Region: rve; pfam00665 1166130000074 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1166130000075 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1166130000076 hinge; other site 1166130000077 active site 1166130000078 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1166130000079 Thymidylate kinase; Region: Thymidylate_kin; pfam02223 1166130000080 ligand-binding site [chemical binding]; other site 1166130000081 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1166130000082 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166130000083 Walker A motif; other site 1166130000084 ATP binding site [chemical binding]; other site 1166130000085 Walker B motif; other site 1166130000086 arginine finger; other site 1166130000087 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1166130000088 Integrase core domain; Region: rve; pfam00665 1166130000089 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1166130000090 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166130000091 S-adenosylmethionine binding site [chemical binding]; other site 1166130000092 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 1166130000093 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1166130000094 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1166130000095 catalytic residues [active] 1166130000096 catalytic nucleophile [active] 1166130000097 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1166130000098 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1166130000099 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1166130000100 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1166130000101 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130000102 putative substrate translocation pore; other site 1166130000103 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1166130000104 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1166130000105 Integrase core domain; Region: rve; pfam00665 1166130000106 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1166130000107 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1166130000108 Protein of unknown function DUF262; Region: DUF262; pfam03235 1166130000109 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1166130000110 active site 1166130000111 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 1166130000112 TraX protein; Region: TraX; pfam05857 1166130000113 Protein of unknown function (DUF4225); Region: DUF4225; pfam13988 1166130000114 IncFII RepA protein family; Region: IncFII_repA; cl11495 1166130000115 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1166130000116 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 1166130000117 catalytic residues [active] 1166130000118 TrwC relaxase; Region: TrwC; pfam08751 1166130000119 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 1166130000120 conjugal transfer nickase/helicase TraI; Provisional; Region: PRK13709 1166130000121 AAA domain; Region: AAA_30; pfam13604 1166130000122 Family description; Region: UvrD_C_2; pfam13538 1166130000123 DNA helicase TraI; Region: TraI; pfam07057 1166130000124 type IV conjugative transfer system coupling protein TraD; Region: TraD_Ftype; TIGR02759 1166130000125 F sex factor protein N terminal; Region: TraD_N; pfam12615 1166130000126 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1166130000127 Walker A motif; other site 1166130000128 ATP binding site [chemical binding]; other site 1166130000129 Walker B motif; other site 1166130000130 conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731 1166130000131 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 1166130000132 conjugal transfer mating pair stabilization protein TraG; Provisional; Region: PRK13735 1166130000133 conjugal transfer pilus assembly protein TraH; Provisional; Region: PRK13723 1166130000134 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 1166130000135 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 1166130000136 F plasmid transfer operon protein; Region: TraF; pfam13728 1166130000137 conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355 1166130000138 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; cl09883 1166130000139 TraU protein; Region: TraU; cl06067 1166130000140 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1166130000141 conjugal transfer pilus assembly protein TraW; Provisional; Region: PRK13738 1166130000142 Type-F conjugative transfer system protein (TrbI_Ftype); Region: TrbI_Ftype; pfam09677 1166130000143 conjugal transfer ATP-binding protein TraC; Provisional; Region: PRK13721 1166130000144 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 1166130000145 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 1166130000146 conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729 1166130000147 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 1166130000148 TraK protein; Region: TraK; pfam06586 1166130000149 conjugal transfer protein TraK; Provisional; Region: PRK13736 1166130000150 TraE protein; Region: TraE; cl05060 1166130000151 conjugal transfer pilus assembly protein TraL; Provisional; Region: PRK13707 1166130000152 TraA; Region: TraA; cl11503 1166130000153 TraM protein; Region: Tra_M; cl11621 1166130000154 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1166130000155 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1166130000156 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1166130000157 catalytic residue [active] 1166130000158 Domain of unknown function (DUF932); Region: DUF932; pfam06067 1166130000159 small toxic polypeptide; Provisional; Region: PRK09738 1166130000160 PsiA protein; Region: PsiA; cl11646 1166130000161 Plasmid SOS inhibition protein (PsiB); Region: PsiB; cl11633 1166130000162 ParB-like nuclease domain; Region: ParBc; pfam02195 1166130000163 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 1166130000164 Antirestriction protein; Region: Antirestrict; pfam03230 1166130000165 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 1166130000166 DNA methylase; Region: N6_N4_Mtase; cl17433 1166130000167 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1166130000168 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1166130000169 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1166130000170 Walker A motif; other site 1166130000171 ATP binding site [chemical binding]; other site 1166130000172 AAA ATPase domain; Region: AAA_15; pfam13175 1166130000173 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166130000174 Walker A/P-loop; other site 1166130000175 ATP binding site [chemical binding]; other site 1166130000176 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1166130000177 putative active site [active] 1166130000178 putative metal-binding site [ion binding]; other site 1166130000179 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1166130000180 HTH-like domain; Region: HTH_21; pfam13276 1166130000181 Integrase core domain; Region: rve; pfam00665 1166130000182 Integrase core domain; Region: rve_3; pfam13683 1166130000183 Transposase; Region: HTH_Tnp_1; pfam01527 1166130000184 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1166130000185 disulfide bond formation protein B; Provisional; Region: PRK01749 1166130000186 fatty acid metabolism regulator; Provisional; Region: PRK04984 1166130000187 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166130000188 DNA-binding site [nucleotide binding]; DNA binding site 1166130000189 FadR C-terminal domain; Region: FadR_C; pfam07840 1166130000190 SpoVR family protein; Provisional; Region: PRK11767 1166130000191 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1166130000192 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1166130000193 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1166130000194 alanine racemase; Reviewed; Region: dadX; PRK03646 1166130000195 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1166130000196 active site 1166130000197 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1166130000198 substrate binding site [chemical binding]; other site 1166130000199 catalytic residues [active] 1166130000200 dimer interface [polypeptide binding]; other site 1166130000201 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 1166130000202 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1166130000203 TrkA-C domain; Region: TrkA_C; pfam02080 1166130000204 Transporter associated domain; Region: CorC_HlyC; smart01091 1166130000205 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1166130000206 dimer interface [polypeptide binding]; other site 1166130000207 catalytic triad [active] 1166130000208 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 1166130000209 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1166130000210 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1166130000211 catalytic residue [active] 1166130000212 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1166130000213 Flagellar regulator YcgR; Region: YcgR; pfam07317 1166130000214 PilZ domain; Region: PilZ; pfam07238 1166130000215 hypothetical protein; Provisional; Region: PRK10457 1166130000216 trehalase; Provisional; Region: treA; PRK13271 1166130000217 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 1166130000218 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 1166130000219 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 1166130000220 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1166130000221 hypothetical protein; Provisional; Region: PRK07033 1166130000222 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 1166130000223 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1166130000224 ligand binding site [chemical binding]; other site 1166130000225 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 1166130000226 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1166130000227 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1166130000228 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 1166130000229 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 1166130000230 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1166130000231 Protein of unknown function (DUF770); Region: DUF770; pfam05591 1166130000232 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 1166130000233 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1166130000234 Protein of unknown function (DUF796); Region: DUF796; pfam05638 1166130000235 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1166130000236 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1166130000237 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1166130000238 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1166130000239 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1166130000240 phosphopeptide binding site; other site 1166130000241 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 1166130000242 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1166130000243 active site 1166130000244 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 1166130000245 ImpE protein; Region: ImpE; pfam07024 1166130000246 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1166130000247 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1166130000248 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 1166130000249 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 1166130000250 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1166130000251 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166130000252 Walker A motif; other site 1166130000253 ATP binding site [chemical binding]; other site 1166130000254 Walker B motif; other site 1166130000255 arginine finger; other site 1166130000256 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166130000257 Walker A motif; other site 1166130000258 ATP binding site [chemical binding]; other site 1166130000259 Walker B motif; other site 1166130000260 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1166130000261 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1166130000262 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1166130000263 active site 1166130000264 ATP binding site [chemical binding]; other site 1166130000265 substrate binding site [chemical binding]; other site 1166130000266 activation loop (A-loop); other site 1166130000267 Domain of unknown function (DUF1795); Region: DUF1795; cl02256 1166130000268 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1166130000269 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1166130000270 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1166130000271 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 1166130000272 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1166130000273 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1166130000274 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1166130000275 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1166130000276 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1166130000277 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1166130000278 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1166130000279 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1166130000280 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1166130000281 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1166130000282 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1166130000283 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1166130000284 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 1166130000285 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 1166130000286 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1166130000287 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1166130000288 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1166130000289 Domain of unknown function (DUF1795); Region: DUF1795; cl02256 1166130000290 PAAR motif; Region: PAAR_motif; pfam05488 1166130000291 RHS Repeat; Region: RHS_repeat; pfam05593 1166130000292 RHS Repeat; Region: RHS_repeat; cl11982 1166130000293 RHS Repeat; Region: RHS_repeat; pfam05593 1166130000294 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1166130000295 RHS Repeat; Region: RHS_repeat; pfam05593 1166130000296 RHS Repeat; Region: RHS_repeat; pfam05593 1166130000297 RHS Repeat; Region: RHS_repeat; cl11982 1166130000298 RHS Repeat; Region: RHS_repeat; cl11982 1166130000299 RHS protein; Region: RHS; pfam03527 1166130000300 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1166130000301 ADP-ribosyl cyclase, also known as cyclic ADP-ribose hydrolase or CD38; Region: Rib_hydrolase; cl08346 1166130000302 NAD binding site [chemical binding]; other site 1166130000303 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 1166130000304 fumarate hydratase; Provisional; Region: PRK15389 1166130000305 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 1166130000306 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1166130000307 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1166130000308 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1166130000309 transmembrane helices; other site 1166130000310 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1166130000311 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1166130000312 putative active site [active] 1166130000313 putative FMN binding site [chemical binding]; other site 1166130000314 putative substrate binding site [chemical binding]; other site 1166130000315 putative catalytic residue [active] 1166130000316 FMN-binding domain; Region: FMN_bind; cl01081 1166130000317 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 1166130000318 L-aspartate oxidase; Provisional; Region: PRK06175 1166130000319 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1166130000320 ApbE family; Region: ApbE; pfam02424 1166130000321 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 1166130000322 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130000323 active site 1166130000324 phosphorylation site [posttranslational modification] 1166130000325 intermolecular recognition site; other site 1166130000326 dimerization interface [polypeptide binding]; other site 1166130000327 Transcriptional regulator; Region: CitT; pfam12431 1166130000328 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1166130000329 PAS domain; Region: PAS; smart00091 1166130000330 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166130000331 ATP binding site [chemical binding]; other site 1166130000332 Mg2+ binding site [ion binding]; other site 1166130000333 G-X-G motif; other site 1166130000334 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1166130000335 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1166130000336 putative active site [active] 1166130000337 malate:quinone oxidoreductase; Validated; Region: PRK05257 1166130000338 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1166130000339 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1166130000340 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166130000341 Walker A motif; other site 1166130000342 ATP binding site [chemical binding]; other site 1166130000343 Walker B motif; other site 1166130000344 arginine finger; other site 1166130000345 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1166130000346 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1166130000347 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1166130000348 NAD(P) binding site [chemical binding]; other site 1166130000349 catalytic residues [active] 1166130000350 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1166130000351 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1166130000352 NAD binding site [chemical binding]; other site 1166130000353 substrate binding site [chemical binding]; other site 1166130000354 catalytic Zn binding site [ion binding]; other site 1166130000355 tetramer interface [polypeptide binding]; other site 1166130000356 structural Zn binding site [ion binding]; other site 1166130000357 Partial alpha/beta-hydrolase lipase region; Region: Abhydro_lipase; pfam04083 1166130000358 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1166130000359 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1166130000360 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 1166130000361 DNA binding residues [nucleotide binding] 1166130000362 putative dimer interface [polypeptide binding]; other site 1166130000363 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1166130000364 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1166130000365 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1166130000366 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1166130000367 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1166130000368 conserved cys residue [active] 1166130000369 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130000370 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130000371 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 1166130000372 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 1166130000373 dimerization interface [polypeptide binding]; other site 1166130000374 metal binding site [ion binding]; metal-binding site 1166130000375 General stress protein [General function prediction only]; Region: GsiB; COG3729 1166130000376 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1166130000377 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1166130000378 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 1166130000379 4Fe-4S binding domain; Region: Fer4; pfam00037 1166130000380 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1166130000381 [4Fe-4S] binding site [ion binding]; other site 1166130000382 molybdopterin cofactor binding site; other site 1166130000383 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1166130000384 molybdopterin cofactor binding site; other site 1166130000385 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1166130000386 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1166130000387 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1166130000388 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1166130000389 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1166130000390 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1166130000391 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 1166130000392 homotrimer interaction site [polypeptide binding]; other site 1166130000393 putative active site [active] 1166130000394 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1166130000395 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1166130000396 heme binding site [chemical binding]; other site 1166130000397 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1166130000398 heme binding site [chemical binding]; other site 1166130000399 Protein of unknown function (DUF1264); Region: DUF1264; pfam06884 1166130000400 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1166130000401 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1166130000402 dimanganese center [ion binding]; other site 1166130000403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 1166130000404 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1166130000405 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1166130000406 MarR family; Region: MarR_2; cl17246 1166130000407 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1166130000408 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 1166130000409 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1166130000410 HlyD family secretion protein; Region: HlyD_3; pfam13437 1166130000411 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1166130000412 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130000413 putative substrate translocation pore; other site 1166130000414 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130000415 enterobactin exporter EntS; Provisional; Region: PRK10489 1166130000416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130000417 putative substrate translocation pore; other site 1166130000418 transcriptional regulator MirA; Provisional; Region: PRK15043 1166130000419 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 1166130000420 DNA binding residues [nucleotide binding] 1166130000421 Sensors of blue-light using FAD; Region: BLUF; smart01034 1166130000422 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1166130000423 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 1166130000424 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1166130000425 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1166130000426 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1166130000427 NAD(P) binding site [chemical binding]; other site 1166130000428 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1166130000429 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 1166130000430 putative phosphoketolase; Provisional; Region: PRK05261 1166130000431 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1166130000432 TPP-binding site; other site 1166130000433 XFP C-terminal domain; Region: XFP_C; pfam09363 1166130000434 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1166130000435 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1166130000436 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1166130000437 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 1166130000438 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1166130000439 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130000440 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1166130000441 dimerization interface [polypeptide binding]; other site 1166130000442 substrate binding pocket [chemical binding]; other site 1166130000443 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1166130000444 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1166130000445 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130000446 Uncharacterized conserved protein [Function unknown]; Region: COG1556 1166130000447 iron-sulfur cluster-binding protein; Region: TIGR00273 1166130000448 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1166130000449 4Fe-4S binding domain; Region: Fer4; cl02805 1166130000450 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1166130000451 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1166130000452 Cysteine-rich domain; Region: CCG; pfam02754 1166130000453 Cysteine-rich domain; Region: CCG; pfam02754 1166130000454 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 1166130000455 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1166130000456 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166130000457 S-adenosylmethionine binding site [chemical binding]; other site 1166130000458 Cupin domain; Region: Cupin_2; cl17218 1166130000459 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1166130000460 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130000461 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130000462 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130000463 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1166130000464 putative substrate translocation pore; other site 1166130000465 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 1166130000466 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1166130000467 active site 1166130000468 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1166130000469 putative dimer interface [polypeptide binding]; other site 1166130000470 catalytic triad [active] 1166130000471 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 1166130000472 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166130000473 dimerization interface [polypeptide binding]; other site 1166130000474 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166130000475 dimer interface [polypeptide binding]; other site 1166130000476 putative CheW interface [polypeptide binding]; other site 1166130000477 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1166130000478 DNA-binding site [nucleotide binding]; DNA binding site 1166130000479 RNA-binding motif; other site 1166130000480 RES domain; Region: RES; cl02411 1166130000481 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1166130000482 ABC transporter transmembrane region; Region: ABC_membrane_3; pfam13748 1166130000483 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1166130000484 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130000485 active site 1166130000486 phosphorylation site [posttranslational modification] 1166130000487 intermolecular recognition site; other site 1166130000488 dimerization interface [polypeptide binding]; other site 1166130000489 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1166130000490 DNA binding site [nucleotide binding] 1166130000491 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1166130000492 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166130000493 dimerization interface [polypeptide binding]; other site 1166130000494 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1166130000495 dimer interface [polypeptide binding]; other site 1166130000496 phosphorylation site [posttranslational modification] 1166130000497 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166130000498 ATP binding site [chemical binding]; other site 1166130000499 Mg2+ binding site [ion binding]; other site 1166130000500 G-X-G motif; other site 1166130000501 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 1166130000502 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 1166130000503 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 1166130000504 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 1166130000505 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1166130000506 Rice tungro bacilliform virus P12 protein; Region: RTBV_P12; pfam06361 1166130000507 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 1166130000508 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1166130000509 HlyD family secretion protein; Region: HlyD_3; pfam13437 1166130000510 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1166130000511 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1166130000512 Cupin domain; Region: Cupin_2; cl17218 1166130000513 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1166130000514 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130000515 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1166130000516 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1166130000517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166130000518 S-adenosylmethionine binding site [chemical binding]; other site 1166130000519 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1166130000520 Uncharacterized conserved protein [Function unknown]; Region: COG3272 1166130000521 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 1166130000522 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 1166130000523 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 1166130000524 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1166130000525 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166130000526 S-adenosylmethionine binding site [chemical binding]; other site 1166130000527 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 1166130000528 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 1166130000529 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1166130000530 short chain dehydrogenase; Provisional; Region: PRK06101 1166130000531 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1166130000532 NAD(P) binding site [chemical binding]; other site 1166130000533 active site 1166130000534 SnoaL-like domain; Region: SnoaL_2; pfam12680 1166130000535 transcriptional regulator MirA; Provisional; Region: PRK15043 1166130000536 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1166130000537 DNA binding residues [nucleotide binding] 1166130000538 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 1166130000539 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1166130000540 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130000541 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1166130000542 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1166130000543 dimerization interface [polypeptide binding]; other site 1166130000544 substrate binding pocket [chemical binding]; other site 1166130000545 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1166130000546 EamA-like transporter family; Region: EamA; pfam00892 1166130000547 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1166130000548 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1166130000549 active site 1166130000550 Zn binding site [ion binding]; other site 1166130000551 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1166130000552 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1166130000553 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1166130000554 DNA binding residues [nucleotide binding] 1166130000555 dimerization interface [polypeptide binding]; other site 1166130000556 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1166130000557 Interdomain contacts; other site 1166130000558 Cytokine receptor motif; other site 1166130000559 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1166130000560 Interdomain contacts; other site 1166130000561 Cytokine receptor motif; other site 1166130000562 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1166130000563 active site 1166130000564 Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495 1166130000565 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 1166130000566 GTP-binding protein YchF; Reviewed; Region: PRK09601 1166130000567 YchF GTPase; Region: YchF; cd01900 1166130000568 G1 box; other site 1166130000569 GTP/Mg2+ binding site [chemical binding]; other site 1166130000570 Switch I region; other site 1166130000571 G2 box; other site 1166130000572 Switch II region; other site 1166130000573 G3 box; other site 1166130000574 G4 box; other site 1166130000575 G5 box; other site 1166130000576 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1166130000577 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1166130000578 putative active site [active] 1166130000579 catalytic residue [active] 1166130000580 hypothetical protein; Provisional; Region: PRK10692 1166130000581 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1166130000582 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 1166130000583 DNA binding residues [nucleotide binding] 1166130000584 putative dimer interface [polypeptide binding]; other site 1166130000585 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1166130000586 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1166130000587 putative transporter; Provisional; Region: PRK11660 1166130000588 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1166130000589 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1166130000590 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1166130000591 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1166130000592 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1166130000593 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1166130000594 active site 1166130000595 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 1166130000596 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1166130000597 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1166130000598 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 1166130000599 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1166130000600 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1166130000601 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1166130000602 tRNA; other site 1166130000603 putative tRNA binding site [nucleotide binding]; other site 1166130000604 putative NADP binding site [chemical binding]; other site 1166130000605 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1166130000606 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1166130000607 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1166130000608 RF-1 domain; Region: RF-1; pfam00472 1166130000609 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1166130000610 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166130000611 hypothetical protein; Provisional; Region: PRK10278 1166130000612 hypothetical protein; Provisional; Region: PRK10941 1166130000613 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 1166130000614 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1166130000615 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1166130000616 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 1166130000617 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1166130000618 cation transport regulator; Reviewed; Region: chaB; PRK09582 1166130000619 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 1166130000620 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1166130000621 putative active site pocket [active] 1166130000622 dimerization interface [polypeptide binding]; other site 1166130000623 putative catalytic residue [active] 1166130000624 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 1166130000625 Cache domain; Region: Cache_1; pfam02743 1166130000626 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166130000627 dimerization interface [polypeptide binding]; other site 1166130000628 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1166130000629 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166130000630 dimer interface [polypeptide binding]; other site 1166130000631 putative CheW interface [polypeptide binding]; other site 1166130000632 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 1166130000633 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1166130000634 substrate binding site [chemical binding]; other site 1166130000635 putative invasin; Provisional; Region: PRK10177 1166130000636 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1166130000637 transcriptional regulator NarL; Provisional; Region: PRK10651 1166130000638 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130000639 active site 1166130000640 phosphorylation site [posttranslational modification] 1166130000641 intermolecular recognition site; other site 1166130000642 dimerization interface [polypeptide binding]; other site 1166130000643 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1166130000644 DNA binding residues [nucleotide binding] 1166130000645 dimerization interface [polypeptide binding]; other site 1166130000646 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 1166130000647 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1166130000648 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166130000649 dimerization interface [polypeptide binding]; other site 1166130000650 Histidine kinase; Region: HisKA_3; pfam07730 1166130000651 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166130000652 ATP binding site [chemical binding]; other site 1166130000653 Mg2+ binding site [ion binding]; other site 1166130000654 G-X-G motif; other site 1166130000655 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1166130000656 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1166130000657 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1166130000658 [4Fe-4S] binding site [ion binding]; other site 1166130000659 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1166130000660 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1166130000661 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1166130000662 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1166130000663 molybdopterin cofactor binding site; other site 1166130000664 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1166130000665 4Fe-4S binding domain; Region: Fer4; cl02805 1166130000666 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1166130000667 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 1166130000668 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1166130000669 EamA-like transporter family; Region: EamA; pfam00892 1166130000670 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1166130000671 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1166130000672 putative DNA binding site [nucleotide binding]; other site 1166130000673 putative Zn2+ binding site [ion binding]; other site 1166130000674 AsnC family; Region: AsnC_trans_reg; pfam01037 1166130000675 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1166130000676 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1166130000677 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1166130000678 putative active site [active] 1166130000679 putative substrate binding site [chemical binding]; other site 1166130000680 putative cosubstrate binding site; other site 1166130000681 catalytic site [active] 1166130000682 hypothetical protein; Provisional; Region: PRK01617 1166130000683 hypothetical protein; Provisional; Region: PRK10279 1166130000684 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1166130000685 active site 1166130000686 nucleophile elbow; other site 1166130000687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130000688 active site 1166130000689 response regulator of RpoS; Provisional; Region: PRK10693 1166130000690 phosphorylation site [posttranslational modification] 1166130000691 intermolecular recognition site; other site 1166130000692 dimerization interface [polypeptide binding]; other site 1166130000693 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1166130000694 tetramer interface; other site 1166130000695 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1166130000696 active site 1166130000697 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 1166130000698 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1166130000699 thymidine kinase; Provisional; Region: PRK04296 1166130000700 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1166130000701 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1166130000702 putative catalytic cysteine [active] 1166130000703 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1166130000704 putative active site [active] 1166130000705 metal binding site [ion binding]; metal-binding site 1166130000706 hypothetical protein; Provisional; Region: PRK11111 1166130000707 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1166130000708 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1166130000709 peptide binding site [polypeptide binding]; other site 1166130000710 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1166130000711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130000712 dimer interface [polypeptide binding]; other site 1166130000713 conserved gate region; other site 1166130000714 putative PBP binding loops; other site 1166130000715 ABC-ATPase subunit interface; other site 1166130000716 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 1166130000717 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1166130000718 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130000719 dimer interface [polypeptide binding]; other site 1166130000720 conserved gate region; other site 1166130000721 putative PBP binding loops; other site 1166130000722 ABC-ATPase subunit interface; other site 1166130000723 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 1166130000724 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1166130000725 Walker A/P-loop; other site 1166130000726 ATP binding site [chemical binding]; other site 1166130000727 Q-loop/lid; other site 1166130000728 ABC transporter signature motif; other site 1166130000729 Walker B; other site 1166130000730 D-loop; other site 1166130000731 H-loop/switch region; other site 1166130000732 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1166130000733 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1166130000734 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1166130000735 Walker A/P-loop; other site 1166130000736 ATP binding site [chemical binding]; other site 1166130000737 Q-loop/lid; other site 1166130000738 ABC transporter signature motif; other site 1166130000739 Walker B; other site 1166130000740 D-loop; other site 1166130000741 H-loop/switch region; other site 1166130000742 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1166130000743 dsDNA-mimic protein; Reviewed; Region: PRK05094 1166130000744 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1166130000745 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1166130000746 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 1166130000747 putative active site [active] 1166130000748 catalytic site [active] 1166130000749 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 1166130000750 putative active site [active] 1166130000751 catalytic site [active] 1166130000752 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1166130000753 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1166130000754 YciI-like protein; Reviewed; Region: PRK11370 1166130000755 transport protein TonB; Provisional; Region: PRK10819 1166130000756 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1166130000757 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1166130000758 intracellular septation protein A; Reviewed; Region: PRK00259 1166130000759 hypothetical protein; Provisional; Region: PRK02868 1166130000760 outer membrane protein W; Provisional; Region: PRK10959 1166130000761 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 1166130000762 putative ion selectivity filter; other site 1166130000763 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1166130000764 putative pore gating glutamate residue; other site 1166130000765 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1166130000766 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1166130000767 substrate binding site [chemical binding]; other site 1166130000768 active site 1166130000769 catalytic residues [active] 1166130000770 heterodimer interface [polypeptide binding]; other site 1166130000771 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1166130000772 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1166130000773 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130000774 catalytic residue [active] 1166130000775 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 1166130000776 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1166130000777 active site 1166130000778 ribulose/triose binding site [chemical binding]; other site 1166130000779 phosphate binding site [ion binding]; other site 1166130000780 substrate (anthranilate) binding pocket [chemical binding]; other site 1166130000781 product (indole) binding pocket [chemical binding]; other site 1166130000782 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1166130000783 active site 1166130000784 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 1166130000785 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1166130000786 glutamine binding [chemical binding]; other site 1166130000787 catalytic triad [active] 1166130000788 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1166130000789 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1166130000790 anthranilate synthase component I; Provisional; Region: PRK13564 1166130000791 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1166130000792 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1166130000793 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1166130000794 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1166130000795 active site 1166130000796 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1166130000797 hypothetical protein; Provisional; Region: PRK11630 1166130000798 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 1166130000799 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1166130000800 RNA binding surface [nucleotide binding]; other site 1166130000801 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 1166130000802 probable active site [active] 1166130000803 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1166130000804 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1166130000805 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986 1166130000806 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 1166130000807 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 1166130000808 NADP binding site [chemical binding]; other site 1166130000809 homodimer interface [polypeptide binding]; other site 1166130000810 active site 1166130000811 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 1166130000812 putative inner membrane peptidase; Provisional; Region: PRK11778 1166130000813 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1166130000814 tandem repeat interface [polypeptide binding]; other site 1166130000815 oligomer interface [polypeptide binding]; other site 1166130000816 active site residues [active] 1166130000817 hypothetical protein; Provisional; Region: PRK11037 1166130000818 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1166130000819 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1166130000820 active site 1166130000821 interdomain interaction site; other site 1166130000822 putative metal-binding site [ion binding]; other site 1166130000823 nucleotide binding site [chemical binding]; other site 1166130000824 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1166130000825 domain I; other site 1166130000826 DNA binding groove [nucleotide binding] 1166130000827 phosphate binding site [ion binding]; other site 1166130000828 domain II; other site 1166130000829 domain III; other site 1166130000830 nucleotide binding site [chemical binding]; other site 1166130000831 catalytic site [active] 1166130000832 domain IV; other site 1166130000833 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1166130000834 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1166130000835 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1166130000836 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1166130000837 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 1166130000838 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130000839 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 1166130000840 substrate binding site [chemical binding]; other site 1166130000841 putative dimerization interface [polypeptide binding]; other site 1166130000842 aconitate hydratase; Validated; Region: PRK09277 1166130000843 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1166130000844 substrate binding site [chemical binding]; other site 1166130000845 ligand binding site [chemical binding]; other site 1166130000846 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1166130000847 substrate binding site [chemical binding]; other site 1166130000848 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1166130000849 dimerization interface [polypeptide binding]; other site 1166130000850 active site 1166130000851 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1166130000852 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1166130000853 active site 1166130000854 Predicted membrane protein [Function unknown]; Region: COG3771 1166130000855 tetratricopeptide repeat protein; Provisional; Region: PRK11788 1166130000856 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1166130000857 TPR motif; other site 1166130000858 binding surface 1166130000859 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1166130000860 active site 1166130000861 dimer interface [polypeptide binding]; other site 1166130000862 translation initiation factor Sui1; Validated; Region: PRK06824 1166130000863 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 1166130000864 putative rRNA binding site [nucleotide binding]; other site 1166130000865 lipoprotein; Provisional; Region: PRK10540 1166130000866 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1166130000867 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1166130000868 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1166130000869 hypothetical protein; Provisional; Region: PRK13658 1166130000870 enoyl-CoA hydratase; Validated; Region: PRK08788 1166130000871 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1166130000872 substrate binding site [chemical binding]; other site 1166130000873 oxyanion hole (OAH) forming residues; other site 1166130000874 trimer interface [polypeptide binding]; other site 1166130000875 RNase II stability modulator; Provisional; Region: PRK10060 1166130000876 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1166130000877 putative active site [active] 1166130000878 heme pocket [chemical binding]; other site 1166130000879 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166130000880 metal binding site [ion binding]; metal-binding site 1166130000881 active site 1166130000882 I-site; other site 1166130000883 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1166130000884 exoribonuclease II; Provisional; Region: PRK05054 1166130000885 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1166130000886 RNB domain; Region: RNB; pfam00773 1166130000887 S1 RNA binding domain; Region: S1; pfam00575 1166130000888 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 1166130000889 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1166130000890 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 1166130000891 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1166130000892 NAD binding site [chemical binding]; other site 1166130000893 homotetramer interface [polypeptide binding]; other site 1166130000894 homodimer interface [polypeptide binding]; other site 1166130000895 substrate binding site [chemical binding]; other site 1166130000896 active site 1166130000897 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 1166130000898 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1166130000899 Walker A/P-loop; other site 1166130000900 ATP binding site [chemical binding]; other site 1166130000901 Q-loop/lid; other site 1166130000902 ABC transporter signature motif; other site 1166130000903 Walker B; other site 1166130000904 D-loop; other site 1166130000905 H-loop/switch region; other site 1166130000906 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 1166130000907 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1166130000908 Walker A/P-loop; other site 1166130000909 ATP binding site [chemical binding]; other site 1166130000910 Q-loop/lid; other site 1166130000911 ABC transporter signature motif; other site 1166130000912 Walker B; other site 1166130000913 D-loop; other site 1166130000914 H-loop/switch region; other site 1166130000915 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1166130000916 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 1166130000917 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1166130000918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130000919 putative PBP binding loops; other site 1166130000920 dimer interface [polypeptide binding]; other site 1166130000921 ABC-ATPase subunit interface; other site 1166130000922 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 1166130000923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130000924 dimer interface [polypeptide binding]; other site 1166130000925 ABC-ATPase subunit interface; other site 1166130000926 putative PBP binding loops; other site 1166130000927 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1166130000928 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1166130000929 peptide binding site [polypeptide binding]; other site 1166130000930 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 1166130000931 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166130000932 Walker A motif; other site 1166130000933 ATP binding site [chemical binding]; other site 1166130000934 Walker B motif; other site 1166130000935 arginine finger; other site 1166130000936 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1166130000937 phage shock protein PspA; Provisional; Region: PRK10698 1166130000938 phage shock protein B; Provisional; Region: pspB; PRK09458 1166130000939 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 1166130000940 phage shock protein C; Region: phageshock_pspC; TIGR02978 1166130000941 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 1166130000942 Predicted ATPase [General function prediction only]; Region: COG3106 1166130000943 hypothetical protein; Provisional; Region: PRK05415 1166130000944 Domain of unknown function (DUF697); Region: DUF697; cl12064 1166130000945 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 1166130000946 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1166130000947 PAS domain; Region: PAS; smart00091 1166130000948 putative active site [active] 1166130000949 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166130000950 Walker A motif; other site 1166130000951 ATP binding site [chemical binding]; other site 1166130000952 Walker B motif; other site 1166130000953 arginine finger; other site 1166130000954 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1166130000955 dimer interface [polypeptide binding]; other site 1166130000956 catalytic triad [active] 1166130000957 peroxidatic and resolving cysteines [active] 1166130000958 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 1166130000959 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1166130000960 active site 1166130000961 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 1166130000962 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 1166130000963 putative active site [active] 1166130000964 Zn binding site [ion binding]; other site 1166130000965 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1166130000966 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1166130000967 peptide binding site [polypeptide binding]; other site 1166130000968 PAS domain S-box; Region: sensory_box; TIGR00229 1166130000969 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1166130000970 putative active site [active] 1166130000971 heme pocket [chemical binding]; other site 1166130000972 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1166130000973 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166130000974 metal binding site [ion binding]; metal-binding site 1166130000975 active site 1166130000976 I-site; other site 1166130000977 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1166130000978 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1166130000979 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1166130000980 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1166130000981 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1166130000982 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166130000983 metal binding site [ion binding]; metal-binding site 1166130000984 active site 1166130000985 I-site; other site 1166130000986 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1166130000987 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1166130000988 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166130000989 dimer interface [polypeptide binding]; other site 1166130000990 putative CheW interface [polypeptide binding]; other site 1166130000991 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1166130000992 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 1166130000993 Cl binding site [ion binding]; other site 1166130000994 oligomer interface [polypeptide binding]; other site 1166130000995 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 1166130000996 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1166130000997 ATP binding site [chemical binding]; other site 1166130000998 Mg++ binding site [ion binding]; other site 1166130000999 motif III; other site 1166130001000 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1166130001001 nucleotide binding region [chemical binding]; other site 1166130001002 ATP-binding site [chemical binding]; other site 1166130001003 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 1166130001004 putative RNA binding site [nucleotide binding]; other site 1166130001005 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1166130001006 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1166130001007 Ligand Binding Site [chemical binding]; other site 1166130001008 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 1166130001009 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1166130001010 catalytic core [active] 1166130001011 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1166130001012 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1166130001013 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130001014 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1166130001015 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1166130001016 KTSC domain; Region: KTSC; pfam13619 1166130001017 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1166130001018 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1166130001019 dimer interface [polypeptide binding]; other site 1166130001020 PYR/PP interface [polypeptide binding]; other site 1166130001021 TPP binding site [chemical binding]; other site 1166130001022 substrate binding site [chemical binding]; other site 1166130001023 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1166130001024 Domain of unknown function; Region: EKR; smart00890 1166130001025 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1166130001026 4Fe-4S binding domain; Region: Fer4; pfam00037 1166130001027 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1166130001028 TPP-binding site [chemical binding]; other site 1166130001029 dimer interface [polypeptide binding]; other site 1166130001030 Cache domain; Region: Cache_1; pfam02743 1166130001031 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1166130001032 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166130001033 metal binding site [ion binding]; metal-binding site 1166130001034 active site 1166130001035 I-site; other site 1166130001036 META domain; Region: META; cl01245 1166130001037 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1166130001038 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 1166130001039 putative ligand binding site [chemical binding]; other site 1166130001040 putative NAD binding site [chemical binding]; other site 1166130001041 catalytic site [active] 1166130001042 hypothetical protein; Provisional; Region: PRK10695 1166130001043 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 1166130001044 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 1166130001045 azoreductase; Reviewed; Region: PRK00170 1166130001046 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1166130001047 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 1166130001048 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1166130001049 ATP binding site [chemical binding]; other site 1166130001050 putative Mg++ binding site [ion binding]; other site 1166130001051 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1166130001052 nucleotide binding region [chemical binding]; other site 1166130001053 ATP-binding site [chemical binding]; other site 1166130001054 Helicase associated domain (HA2); Region: HA2; pfam04408 1166130001055 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1166130001056 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1166130001057 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1166130001058 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1166130001059 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1166130001060 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1166130001061 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1166130001062 HlyD family secretion protein; Region: HlyD_3; pfam13437 1166130001063 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130001064 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1166130001065 putative substrate translocation pore; other site 1166130001066 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166130001067 Coenzyme A binding pocket [chemical binding]; other site 1166130001068 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1166130001069 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1166130001070 putative active site [active] 1166130001071 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 1166130001072 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1166130001073 NAD binding site [chemical binding]; other site 1166130001074 catalytic residues [active] 1166130001075 substrate binding site [chemical binding]; other site 1166130001076 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1166130001077 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1166130001078 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1166130001079 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1166130001080 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1166130001081 cytochrome b561; Provisional; Region: PRK11513 1166130001082 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130001083 metabolite-proton symporter; Region: 2A0106; TIGR00883 1166130001084 putative substrate translocation pore; other site 1166130001085 LysE type translocator; Region: LysE; cl00565 1166130001086 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1166130001087 putative metal binding site [ion binding]; other site 1166130001088 putative homodimer interface [polypeptide binding]; other site 1166130001089 putative homotetramer interface [polypeptide binding]; other site 1166130001090 putative homodimer-homodimer interface [polypeptide binding]; other site 1166130001091 putative allosteric switch controlling residues; other site 1166130001092 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1166130001093 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1166130001094 substrate binding site [chemical binding]; other site 1166130001095 catalytic Zn binding site [ion binding]; other site 1166130001096 NAD binding site [chemical binding]; other site 1166130001097 structural Zn binding site [ion binding]; other site 1166130001098 dimer interface [polypeptide binding]; other site 1166130001099 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 1166130001100 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1166130001101 dimer interface [polypeptide binding]; other site 1166130001102 ligand binding site [chemical binding]; other site 1166130001103 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166130001104 dimerization interface [polypeptide binding]; other site 1166130001105 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166130001106 dimer interface [polypeptide binding]; other site 1166130001107 putative CheW interface [polypeptide binding]; other site 1166130001108 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 1166130001109 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 1166130001110 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1166130001111 putative DNA binding site [nucleotide binding]; other site 1166130001112 putative Zn2+ binding site [ion binding]; other site 1166130001113 arsenical pump membrane protein; Provisional; Region: PRK15445 1166130001114 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1166130001115 transmembrane helices; other site 1166130001116 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1166130001117 ArsC family; Region: ArsC; pfam03960 1166130001118 catalytic residues [active] 1166130001119 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1166130001120 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1166130001121 putative molybdopterin cofactor binding site [chemical binding]; other site 1166130001122 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1166130001123 putative molybdopterin cofactor binding site; other site 1166130001124 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130001125 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1166130001126 dimerization interface [polypeptide binding]; other site 1166130001127 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 1166130001128 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 1166130001129 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1166130001130 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1166130001131 substrate binding pocket [chemical binding]; other site 1166130001132 catalytic triad [active] 1166130001133 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1166130001134 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130001135 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1166130001136 dimerization interface [polypeptide binding]; other site 1166130001137 putative aminotransferase; Provisional; Region: PRK12414 1166130001138 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1166130001139 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130001140 homodimer interface [polypeptide binding]; other site 1166130001141 catalytic residue [active] 1166130001142 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1166130001143 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166130001144 substrate binding pocket [chemical binding]; other site 1166130001145 membrane-bound complex binding site; other site 1166130001146 hinge residues; other site 1166130001147 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 1166130001148 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 1166130001149 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1166130001150 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166130001151 Coenzyme A binding pocket [chemical binding]; other site 1166130001152 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1166130001153 RNA polymerase sigma factor; Provisional; Region: PRK12511 1166130001154 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1166130001155 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1166130001156 DNA binding residues [nucleotide binding] 1166130001157 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1166130001158 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 1166130001159 putative heme binding pocket [chemical binding]; other site 1166130001160 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 1166130001161 putative trimer interface [polypeptide binding]; other site 1166130001162 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1166130001163 putative CoA binding site [chemical binding]; other site 1166130001164 putative trimer interface [polypeptide binding]; other site 1166130001165 putative CoA binding site [chemical binding]; other site 1166130001166 tellurite resistance protein TehB; Provisional; Region: PRK11207 1166130001167 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166130001168 S-adenosylmethionine binding site [chemical binding]; other site 1166130001169 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 1166130001170 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1166130001171 metal binding site [ion binding]; metal-binding site 1166130001172 dimer interface [polypeptide binding]; other site 1166130001173 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1166130001174 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1166130001175 peptide binding site [polypeptide binding]; other site 1166130001176 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 1166130001177 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1166130001178 EamA-like transporter family; Region: EamA; pfam00892 1166130001179 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1166130001180 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130001181 benzoate transporter; Region: benE; TIGR00843 1166130001182 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 1166130001183 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1166130001184 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1166130001185 non-specific DNA binding site [nucleotide binding]; other site 1166130001186 salt bridge; other site 1166130001187 sequence-specific DNA binding site [nucleotide binding]; other site 1166130001188 Cupin domain; Region: Cupin_2; pfam07883 1166130001189 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1166130001190 Peptidase family U32; Region: Peptidase_U32; pfam01136 1166130001191 Collagenase; Region: DUF3656; pfam12392 1166130001192 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166130001193 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130001194 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1166130001195 putative effector binding pocket; other site 1166130001196 dimerization interface [polypeptide binding]; other site 1166130001197 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 1166130001198 putative FMN binding site [chemical binding]; other site 1166130001199 Xanthomonas XOO_2897-like deaminase; Region: XOO_2897-deam; pfam14440 1166130001200 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 1166130001201 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1166130001202 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1166130001203 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1166130001204 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1166130001205 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1166130001206 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166130001207 DNA-binding site [nucleotide binding]; DNA binding site 1166130001208 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1166130001209 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130001210 homodimer interface [polypeptide binding]; other site 1166130001211 catalytic residue [active] 1166130001212 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1166130001213 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1166130001214 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1166130001215 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166130001216 Walker A/P-loop; other site 1166130001217 ATP binding site [chemical binding]; other site 1166130001218 Q-loop/lid; other site 1166130001219 ABC transporter signature motif; other site 1166130001220 Walker B; other site 1166130001221 D-loop; other site 1166130001222 H-loop/switch region; other site 1166130001223 TOBE domain; Region: TOBE_2; pfam08402 1166130001224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130001225 dimer interface [polypeptide binding]; other site 1166130001226 conserved gate region; other site 1166130001227 putative PBP binding loops; other site 1166130001228 ABC-ATPase subunit interface; other site 1166130001229 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1166130001230 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130001231 putative PBP binding loops; other site 1166130001232 dimer interface [polypeptide binding]; other site 1166130001233 ABC-ATPase subunit interface; other site 1166130001234 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 1166130001235 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 1166130001236 tetrameric interface [polypeptide binding]; other site 1166130001237 NAD binding site [chemical binding]; other site 1166130001238 catalytic residues [active] 1166130001239 substrate binding site [chemical binding]; other site 1166130001240 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1166130001241 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1166130001242 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 1166130001243 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 1166130001244 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1166130001245 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1166130001246 catalytic site [active] 1166130001247 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458 1166130001248 Virulence factor SrfB; Region: SrfB; pfam07520 1166130001249 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1166130001250 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1166130001251 peptide binding site [polypeptide binding]; other site 1166130001252 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 1166130001253 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1166130001254 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1166130001255 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166130001256 Coenzyme A binding pocket [chemical binding]; other site 1166130001257 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1166130001258 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1166130001259 sequence-specific DNA binding site [nucleotide binding]; other site 1166130001260 salt bridge; other site 1166130001261 Cupin domain; Region: Cupin_2; pfam07883 1166130001262 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1166130001263 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1166130001264 NAD(P) binding site [chemical binding]; other site 1166130001265 substrate binding site [chemical binding]; other site 1166130001266 dimer interface [polypeptide binding]; other site 1166130001267 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 1166130001268 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166130001269 DNA-binding site [nucleotide binding]; DNA binding site 1166130001270 FCD domain; Region: FCD; pfam07729 1166130001271 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166130001272 dimerization interface [polypeptide binding]; other site 1166130001273 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1166130001274 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166130001275 dimer interface [polypeptide binding]; other site 1166130001276 putative CheW interface [polypeptide binding]; other site 1166130001277 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166130001278 Coenzyme A binding pocket [chemical binding]; other site 1166130001279 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1166130001280 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1166130001281 N-terminal plug; other site 1166130001282 ligand-binding site [chemical binding]; other site 1166130001283 PQQ-like domain; Region: PQQ_2; pfam13360 1166130001284 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1166130001285 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1166130001286 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1166130001287 L-asparagine permease; Provisional; Region: PRK15049 1166130001288 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1166130001289 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1166130001290 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1166130001291 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1166130001292 metal binding site [ion binding]; metal-binding site 1166130001293 dimer interface [polypeptide binding]; other site 1166130001294 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1166130001295 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1166130001296 active site 1166130001297 non-prolyl cis peptide bond; other site 1166130001298 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1166130001299 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166130001300 substrate binding pocket [chemical binding]; other site 1166130001301 membrane-bound complex binding site; other site 1166130001302 hinge residues; other site 1166130001303 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166130001304 Coenzyme A binding pocket [chemical binding]; other site 1166130001305 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130001306 dimer interface [polypeptide binding]; other site 1166130001307 conserved gate region; other site 1166130001308 putative PBP binding loops; other site 1166130001309 ABC-ATPase subunit interface; other site 1166130001310 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1166130001311 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1166130001312 Walker A/P-loop; other site 1166130001313 ATP binding site [chemical binding]; other site 1166130001314 Q-loop/lid; other site 1166130001315 ABC transporter signature motif; other site 1166130001316 Walker B; other site 1166130001317 D-loop; other site 1166130001318 H-loop/switch region; other site 1166130001319 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1166130001320 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166130001321 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1166130001322 substrate binding pocket [chemical binding]; other site 1166130001323 membrane-bound complex binding site; other site 1166130001324 hinge residues; other site 1166130001325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130001326 D-galactonate transporter; Region: 2A0114; TIGR00893 1166130001327 putative substrate translocation pore; other site 1166130001328 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1166130001329 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1166130001330 active site pocket [active] 1166130001331 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1166130001332 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1166130001333 DNA binding site [nucleotide binding] 1166130001334 domain linker motif; other site 1166130001335 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1166130001336 putative dimerization interface [polypeptide binding]; other site 1166130001337 putative ligand binding site [chemical binding]; other site 1166130001338 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 1166130001339 AAA domain; Region: AAA_17; pfam13207 1166130001340 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1166130001341 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1166130001342 C-terminal domain interface [polypeptide binding]; other site 1166130001343 GSH binding site (G-site) [chemical binding]; other site 1166130001344 dimer interface [polypeptide binding]; other site 1166130001345 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1166130001346 dimer interface [polypeptide binding]; other site 1166130001347 N-terminal domain interface [polypeptide binding]; other site 1166130001348 substrate binding pocket (H-site) [chemical binding]; other site 1166130001349 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1166130001350 active site 1166130001351 catalytic triad [active] 1166130001352 oxyanion hole [active] 1166130001353 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1166130001354 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1166130001355 4-oxalocrotonate tautomerase; Provisional; Region: PRK01271 1166130001356 active site 1 [active] 1166130001357 dimer interface [polypeptide binding]; other site 1166130001358 hexamer interface [polypeptide binding]; other site 1166130001359 active site 2 [active] 1166130001360 Putative cyclase; Region: Cyclase; pfam04199 1166130001361 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1166130001362 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1166130001363 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1166130001364 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166130001365 dimerization interface [polypeptide binding]; other site 1166130001366 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1166130001367 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166130001368 metal binding site [ion binding]; metal-binding site 1166130001369 active site 1166130001370 I-site; other site 1166130001371 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1166130001372 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1166130001373 Walker A/P-loop; other site 1166130001374 ATP binding site [chemical binding]; other site 1166130001375 Q-loop/lid; other site 1166130001376 ABC transporter signature motif; other site 1166130001377 Walker B; other site 1166130001378 D-loop; other site 1166130001379 H-loop/switch region; other site 1166130001380 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1166130001381 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1166130001382 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1166130001383 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130001384 dimer interface [polypeptide binding]; other site 1166130001385 conserved gate region; other site 1166130001386 putative PBP binding loops; other site 1166130001387 ABC-ATPase subunit interface; other site 1166130001388 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130001389 dimer interface [polypeptide binding]; other site 1166130001390 conserved gate region; other site 1166130001391 putative PBP binding loops; other site 1166130001392 ABC-ATPase subunit interface; other site 1166130001393 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1166130001394 TetR family transcriptional regulator; Provisional; Region: PRK14996 1166130001395 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1166130001396 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1166130001397 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130001398 putative substrate translocation pore; other site 1166130001399 aromatic amino acid exporter; Provisional; Region: PRK11689 1166130001400 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1166130001401 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1166130001402 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1166130001403 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1166130001404 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1166130001405 molybdopterin cofactor binding site; other site 1166130001406 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1166130001407 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1166130001408 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 1166130001409 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1166130001410 MFS transport protein AraJ; Provisional; Region: PRK10091 1166130001411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130001412 putative substrate translocation pore; other site 1166130001413 CMD domain protein, Avi_7170 family; Region: CMD_Avi_7170; TIGR04029 1166130001414 alkylhydroperoxidase domain protein, Avi_7169 family; Region: perox_Avi_7169; TIGR04030 1166130001415 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 1166130001416 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 1166130001417 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1166130001418 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1166130001419 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1166130001420 Walker A/P-loop; other site 1166130001421 ATP binding site [chemical binding]; other site 1166130001422 Q-loop/lid; other site 1166130001423 ABC transporter signature motif; other site 1166130001424 Walker B; other site 1166130001425 D-loop; other site 1166130001426 H-loop/switch region; other site 1166130001427 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1166130001428 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1166130001429 Walker A/P-loop; other site 1166130001430 ATP binding site [chemical binding]; other site 1166130001431 Q-loop/lid; other site 1166130001432 ABC transporter signature motif; other site 1166130001433 Walker B; other site 1166130001434 D-loop; other site 1166130001435 H-loop/switch region; other site 1166130001436 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1166130001437 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1166130001438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130001439 ABC-ATPase subunit interface; other site 1166130001440 putative PBP binding loops; other site 1166130001441 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1166130001442 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130001443 dimer interface [polypeptide binding]; other site 1166130001444 conserved gate region; other site 1166130001445 putative PBP binding loops; other site 1166130001446 ABC-ATPase subunit interface; other site 1166130001447 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1166130001448 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 1166130001449 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1166130001450 active site 1166130001451 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1166130001452 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1166130001453 NAD binding site [chemical binding]; other site 1166130001454 substrate binding site [chemical binding]; other site 1166130001455 catalytic Zn binding site [ion binding]; other site 1166130001456 tetramer interface [polypeptide binding]; other site 1166130001457 structural Zn binding site [ion binding]; other site 1166130001458 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1166130001459 dimer interface [polypeptide binding]; other site 1166130001460 substrate binding site [chemical binding]; other site 1166130001461 metal binding sites [ion binding]; metal-binding site 1166130001462 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1166130001463 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1166130001464 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1166130001465 malate dehydrogenase; Provisional; Region: PRK13529 1166130001466 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1166130001467 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1166130001468 NAD(P) binding site [chemical binding]; other site 1166130001469 30S ribosomal protein subunit S22 family; Region: Ribosomal_S22; cl11579 1166130001470 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 1166130001471 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1166130001472 FeS/SAM binding site; other site 1166130001473 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130001474 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1166130001475 putative substrate translocation pore; other site 1166130001476 poly(beta-D-mannuronate) lyase; Provisional; Region: algL; PRK00325 1166130001477 active site 1166130001478 PAS domain; Region: PAS_9; pfam13426 1166130001479 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1166130001480 putative active site [active] 1166130001481 heme pocket [chemical binding]; other site 1166130001482 HAMP domain; Region: HAMP; pfam00672 1166130001483 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1166130001484 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166130001485 dimer interface [polypeptide binding]; other site 1166130001486 putative CheW interface [polypeptide binding]; other site 1166130001487 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1166130001488 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1166130001489 Walker A/P-loop; other site 1166130001490 ATP binding site [chemical binding]; other site 1166130001491 Q-loop/lid; other site 1166130001492 ABC transporter signature motif; other site 1166130001493 Walker B; other site 1166130001494 D-loop; other site 1166130001495 H-loop/switch region; other site 1166130001496 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130001497 dimer interface [polypeptide binding]; other site 1166130001498 conserved gate region; other site 1166130001499 putative PBP binding loops; other site 1166130001500 ABC-ATPase subunit interface; other site 1166130001501 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 1166130001502 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130001503 conserved gate region; other site 1166130001504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130001505 putative PBP binding loops; other site 1166130001506 dimer interface [polypeptide binding]; other site 1166130001507 ABC-ATPase subunit interface; other site 1166130001508 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1166130001509 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166130001510 substrate binding pocket [chemical binding]; other site 1166130001511 membrane-bound complex binding site; other site 1166130001512 hinge residues; other site 1166130001513 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1166130001514 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1166130001515 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1166130001516 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166130001517 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1166130001518 DNA-binding site [nucleotide binding]; DNA binding site 1166130001519 FCD domain; Region: FCD; pfam07729 1166130001520 Sensors of blue-light using FAD; Region: BLUF; pfam04940 1166130001521 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1166130001522 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1166130001523 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166130001524 metal binding site [ion binding]; metal-binding site 1166130001525 active site 1166130001526 I-site; other site 1166130001527 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166130001528 Coenzyme A binding pocket [chemical binding]; other site 1166130001529 thiamine pyrophosphate protein; Provisional; Region: PRK08273 1166130001530 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1166130001531 PYR/PP interface [polypeptide binding]; other site 1166130001532 dimer interface [polypeptide binding]; other site 1166130001533 tetramer interface [polypeptide binding]; other site 1166130001534 TPP binding site [chemical binding]; other site 1166130001535 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1166130001536 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1166130001537 TPP-binding site [chemical binding]; other site 1166130001538 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1166130001539 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1166130001540 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1166130001541 Transmembrane secretion effector; Region: MFS_3; pfam05977 1166130001542 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130001543 putative substrate translocation pore; other site 1166130001544 DoxX; Region: DoxX; pfam07681 1166130001545 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1166130001546 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1166130001547 active site 1166130001548 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1166130001549 Isochorismatase family; Region: Isochorismatase; pfam00857 1166130001550 catalytic triad [active] 1166130001551 dimer interface [polypeptide binding]; other site 1166130001552 conserved cis-peptide bond; other site 1166130001553 Protein of unknown function (DUF1427); Region: DUF1427; pfam07235 1166130001554 Protein of unknown function (DUF1427); Region: DUF1427; pfam07235 1166130001555 Response regulator receiver domain; Region: Response_reg; pfam00072 1166130001556 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130001557 active site 1166130001558 phosphorylation site [posttranslational modification] 1166130001559 intermolecular recognition site; other site 1166130001560 dimerization interface [polypeptide binding]; other site 1166130001561 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1166130001562 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1166130001563 substrate binding site [chemical binding]; other site 1166130001564 activation loop (A-loop); other site 1166130001565 Predicted ATPase [General function prediction only]; Region: COG3899 1166130001566 AAA ATPase domain; Region: AAA_16; pfam13191 1166130001567 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1166130001568 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1166130001569 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1166130001570 PAS fold; Region: PAS_3; pfam08447 1166130001571 putative active site [active] 1166130001572 heme pocket [chemical binding]; other site 1166130001573 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1166130001574 dimer interface [polypeptide binding]; other site 1166130001575 phosphorylation site [posttranslational modification] 1166130001576 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166130001577 ATP binding site [chemical binding]; other site 1166130001578 Mg2+ binding site [ion binding]; other site 1166130001579 G-X-G motif; other site 1166130001580 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1166130001581 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130001582 active site 1166130001583 phosphorylation site [posttranslational modification] 1166130001584 intermolecular recognition site; other site 1166130001585 dimerization interface [polypeptide binding]; other site 1166130001586 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1166130001587 DNA binding residues [nucleotide binding] 1166130001588 dimerization interface [polypeptide binding]; other site 1166130001589 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1166130001590 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1166130001591 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1166130001592 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1166130001593 dimer interface [polypeptide binding]; other site 1166130001594 ADP-ribose binding site [chemical binding]; other site 1166130001595 active site 1166130001596 nudix motif; other site 1166130001597 metal binding site [ion binding]; metal-binding site 1166130001598 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1166130001599 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166130001600 S-adenosylmethionine binding site [chemical binding]; other site 1166130001601 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1166130001602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130001603 putative substrate translocation pore; other site 1166130001604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130001605 putative substrate translocation pore; other site 1166130001606 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 1166130001607 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130001608 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 1166130001609 putative substrate binding pocket [chemical binding]; other site 1166130001610 putative dimerization interface [polypeptide binding]; other site 1166130001611 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 1166130001612 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 1166130001613 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1166130001614 catalytic residue [active] 1166130001615 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 1166130001616 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1166130001617 inhibitor-cofactor binding pocket; inhibition site 1166130001618 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130001619 catalytic residue [active] 1166130001620 aspartate kinase III; Validated; Region: PRK09084 1166130001621 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1166130001622 nucleotide binding site [chemical binding]; other site 1166130001623 substrate binding site [chemical binding]; other site 1166130001624 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1166130001625 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1166130001626 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 1166130001627 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 1166130001628 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1166130001629 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1166130001630 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1166130001631 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1166130001632 DNA binding residues [nucleotide binding] 1166130001633 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 1166130001634 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1166130001635 gating phenylalanine in ion channel; other site 1166130001636 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1166130001637 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1166130001638 ATP binding site [chemical binding]; other site 1166130001639 Mg2+ binding site [ion binding]; other site 1166130001640 G-X-G motif; other site 1166130001641 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1166130001642 anti sigma factor interaction site; other site 1166130001643 regulatory phosphorylation site [posttranslational modification]; other site 1166130001644 Response regulator receiver domain; Region: Response_reg; pfam00072 1166130001645 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130001646 active site 1166130001647 phosphorylation site [posttranslational modification] 1166130001648 intermolecular recognition site; other site 1166130001649 dimerization interface [polypeptide binding]; other site 1166130001650 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1166130001651 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1166130001652 OpgC protein; Region: OpgC_C; cl17858 1166130001653 OpgC protein; Region: OpgC_C; cl17858 1166130001654 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1166130001655 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1166130001656 DXD motif; other site 1166130001657 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 1166130001658 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 1166130001659 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 1166130001660 PAS fold; Region: PAS_7; pfam12860 1166130001661 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1166130001662 PAS fold; Region: PAS_3; pfam08447 1166130001663 putative active site [active] 1166130001664 heme pocket [chemical binding]; other site 1166130001665 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1166130001666 dimer interface [polypeptide binding]; other site 1166130001667 phosphorylation site [posttranslational modification] 1166130001668 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166130001669 ATP binding site [chemical binding]; other site 1166130001670 Mg2+ binding site [ion binding]; other site 1166130001671 G-X-G motif; other site 1166130001672 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1166130001673 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130001674 active site 1166130001675 phosphorylation site [posttranslational modification] 1166130001676 intermolecular recognition site; other site 1166130001677 dimerization interface [polypeptide binding]; other site 1166130001678 Response regulator receiver domain; Region: Response_reg; pfam00072 1166130001679 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130001680 active site 1166130001681 phosphorylation site [posttranslational modification] 1166130001682 intermolecular recognition site; other site 1166130001683 dimerization interface [polypeptide binding]; other site 1166130001684 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1166130001685 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1166130001686 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1166130001687 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1166130001688 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1166130001689 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1166130001690 active site 1166130001691 catalytic site [active] 1166130001692 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 1166130001693 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1166130001694 active site 1166130001695 catalytic site [active] 1166130001696 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1166130001697 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1166130001698 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1166130001699 catalytic site [active] 1166130001700 active site 1166130001701 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1166130001702 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 1166130001703 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1166130001704 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1166130001705 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1166130001706 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 1166130001707 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1166130001708 [4Fe-4S] binding site [ion binding]; other site 1166130001709 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1166130001710 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1166130001711 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1166130001712 molybdopterin cofactor binding site; other site 1166130001713 beta-lactamase TEM; Provisional; Region: PRK15442 1166130001714 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1166130001715 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1166130001716 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 1166130001717 NADP binding site [chemical binding]; other site 1166130001718 dimer interface [polypeptide binding]; other site 1166130001719 short chain dehydrogenase; Provisional; Region: PRK06482 1166130001720 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1166130001721 NADP binding site [chemical binding]; other site 1166130001722 active site 1166130001723 steroid binding site; other site 1166130001724 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166130001725 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130001726 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1166130001727 putative effector binding pocket; other site 1166130001728 putative dimerization interface [polypeptide binding]; other site 1166130001729 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1166130001730 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1166130001731 active site 1166130001732 metal binding site [ion binding]; metal-binding site 1166130001733 Cupin domain; Region: Cupin_2; cl17218 1166130001734 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1166130001735 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1166130001736 dimer interface [polypeptide binding]; other site 1166130001737 PYR/PP interface [polypeptide binding]; other site 1166130001738 TPP binding site [chemical binding]; other site 1166130001739 substrate binding site [chemical binding]; other site 1166130001740 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1166130001741 Domain of unknown function; Region: EKR; pfam10371 1166130001742 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1166130001743 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1166130001744 TPP-binding site [chemical binding]; other site 1166130001745 dimer interface [polypeptide binding]; other site 1166130001746 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 1166130001747 nitrogenase iron protein; Region: nifH; TIGR01287 1166130001748 Nucleotide-binding sites [chemical binding]; other site 1166130001749 Walker A motif; other site 1166130001750 Switch I region of nucleotide binding site; other site 1166130001751 Fe4S4 binding sites [ion binding]; other site 1166130001752 Switch II region of nucleotide binding site; other site 1166130001753 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 1166130001754 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 1166130001755 MoFe protein alpha/beta subunit interactions; other site 1166130001756 Alpha subunit P cluster binding residues; other site 1166130001757 FeMoco binding residues [chemical binding]; other site 1166130001758 MoFe protein alpha subunit/Fe protein contacts; other site 1166130001759 MoFe protein dimer/ dimer interactions; other site 1166130001760 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 1166130001761 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 1166130001762 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 1166130001763 MoFe protein beta/alpha subunit interactions; other site 1166130001764 Beta subunit P cluster binding residues; other site 1166130001765 MoFe protein beta subunit/Fe protein contacts; other site 1166130001766 MoFe protein dimer/ dimer interactions; other site 1166130001767 NifT/FixU protein; Region: NifT; pfam06988 1166130001768 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 1166130001769 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 1166130001770 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 1166130001771 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 1166130001772 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 1166130001773 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 1166130001774 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 1166130001775 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1166130001776 trimerization site [polypeptide binding]; other site 1166130001777 active site 1166130001778 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1166130001779 NifU-like domain; Region: NifU; pfam01106 1166130001780 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1166130001781 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1166130001782 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1166130001783 catalytic residue [active] 1166130001784 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 1166130001785 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 1166130001786 active site 1166130001787 catalytic residues [active] 1166130001788 metal binding site [ion binding]; metal-binding site 1166130001789 Nitrogen fixation protein NifW; Region: NifW; cl03935 1166130001790 NifZ domain; Region: NifZ; pfam04319 1166130001791 nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933 1166130001792 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1166130001793 flavodoxin FldA; Validated; Region: PRK09267 1166130001794 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 1166130001795 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1166130001796 putative active site [active] 1166130001797 heme pocket [chemical binding]; other site 1166130001798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166130001799 ATP binding site [chemical binding]; other site 1166130001800 G-X-G motif; other site 1166130001801 Nif-specific regulatory protein; Region: nifA; TIGR01817 1166130001802 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1166130001803 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166130001804 Walker A motif; other site 1166130001805 ATP binding site [chemical binding]; other site 1166130001806 Walker B motif; other site 1166130001807 arginine finger; other site 1166130001808 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1166130001809 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 1166130001810 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1166130001811 FeS/SAM binding site; other site 1166130001812 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 1166130001813 NifQ; Region: NifQ; pfam04891 1166130001814 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 1166130001815 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1166130001816 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1166130001817 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1166130001818 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166130001819 dimer interface [polypeptide binding]; other site 1166130001820 putative CheW interface [polypeptide binding]; other site 1166130001821 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 1166130001822 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1166130001823 NAD binding site [chemical binding]; other site 1166130001824 catalytic residues [active] 1166130001825 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166130001826 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130001827 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1166130001828 putative effector binding pocket; other site 1166130001829 putative dimerization interface [polypeptide binding]; other site 1166130001830 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1166130001831 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 1166130001832 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1166130001833 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166130001834 DNA-binding site [nucleotide binding]; DNA binding site 1166130001835 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1166130001836 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130001837 homodimer interface [polypeptide binding]; other site 1166130001838 catalytic residue [active] 1166130001839 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 1166130001840 altronate oxidoreductase; Provisional; Region: PRK03643 1166130001841 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1166130001842 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1166130001843 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166130001844 Coenzyme A binding pocket [chemical binding]; other site 1166130001845 GAF domain; Region: GAF_2; pfam13185 1166130001846 GAF domain; Region: GAF; pfam01590 1166130001847 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1166130001848 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166130001849 metal binding site [ion binding]; metal-binding site 1166130001850 active site 1166130001851 I-site; other site 1166130001852 MASE2 domain; Region: MASE2; pfam05230 1166130001853 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1166130001854 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166130001855 metal binding site [ion binding]; metal-binding site 1166130001856 active site 1166130001857 I-site; other site 1166130001858 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1166130001859 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166130001860 metal binding site [ion binding]; metal-binding site 1166130001861 active site 1166130001862 I-site; other site 1166130001863 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 1166130001864 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1166130001865 glutaminase; Provisional; Region: PRK00971 1166130001866 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1166130001867 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1166130001868 dimer interface [polypeptide binding]; other site 1166130001869 ligand binding site [chemical binding]; other site 1166130001870 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1166130001871 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166130001872 dimer interface [polypeptide binding]; other site 1166130001873 putative CheW interface [polypeptide binding]; other site 1166130001874 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 1166130001875 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1166130001876 NAD(P) binding site [chemical binding]; other site 1166130001877 catalytic residues [active] 1166130001878 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1166130001879 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130001880 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1166130001881 putative dimerization interface [polypeptide binding]; other site 1166130001882 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1166130001883 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1166130001884 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1166130001885 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1166130001886 NAD binding site [chemical binding]; other site 1166130001887 dimer interface [polypeptide binding]; other site 1166130001888 substrate binding site [chemical binding]; other site 1166130001889 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1166130001890 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1166130001891 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1166130001892 putative arabinose transporter; Provisional; Region: PRK03545 1166130001893 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130001894 putative substrate translocation pore; other site 1166130001895 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1166130001896 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1166130001897 inner membrane protein; Provisional; Region: PRK10995 1166130001898 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 1166130001899 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1166130001900 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 1166130001901 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130001902 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130001903 MarB protein; Region: MarB; pfam13999 1166130001904 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 1166130001905 EamA-like transporter family; Region: EamA; pfam00892 1166130001906 EamA-like transporter family; Region: EamA; pfam00892 1166130001907 putative transporter; Provisional; Region: PRK10054 1166130001908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130001909 putative substrate translocation pore; other site 1166130001910 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1166130001911 substrate binding site [chemical binding]; other site 1166130001912 THF binding site; other site 1166130001913 zinc-binding site [ion binding]; other site 1166130001914 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 1166130001915 active site residue [active] 1166130001916 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1166130001917 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1166130001918 conserved cys residue [active] 1166130001919 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130001920 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130001921 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 1166130001922 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1166130001923 active site 1166130001924 Zn binding site [ion binding]; other site 1166130001925 malonic semialdehyde reductase; Provisional; Region: PRK10538 1166130001926 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 1166130001927 putative NAD(P) binding site [chemical binding]; other site 1166130001928 homodimer interface [polypeptide binding]; other site 1166130001929 homotetramer interface [polypeptide binding]; other site 1166130001930 active site 1166130001931 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1166130001932 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166130001933 DNA-binding site [nucleotide binding]; DNA binding site 1166130001934 FCD domain; Region: FCD; pfam07729 1166130001935 YdfZ protein; Region: YdfZ; pfam14001 1166130001936 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1166130001937 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1166130001938 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1166130001939 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1166130001940 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1166130001941 hypothetical protein; Provisional; Region: PRK02237 1166130001942 hypothetical protein; Provisional; Region: PRK13659 1166130001943 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 1166130001944 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1166130001945 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 1166130001946 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1166130001947 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1166130001948 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130001949 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1166130001950 dimerization interface [polypeptide binding]; other site 1166130001951 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 1166130001952 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1166130001953 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1166130001954 putative [Fe4-S4] binding site [ion binding]; other site 1166130001955 putative molybdopterin cofactor binding site [chemical binding]; other site 1166130001956 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1166130001957 putative molybdopterin cofactor binding site; other site 1166130001958 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1166130001959 4Fe-4S binding domain; Region: Fer4; pfam00037 1166130001960 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 1166130001961 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 1166130001962 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1166130001963 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1166130001964 Transposase; Region: HTH_Tnp_1; pfam01527 1166130001965 HTH-like domain; Region: HTH_21; pfam13276 1166130001966 Integrase core domain; Region: rve; pfam00665 1166130001967 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1166130001968 GAF domain; Region: GAF; pfam01590 1166130001969 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1166130001970 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166130001971 metal binding site [ion binding]; metal-binding site 1166130001972 active site 1166130001973 I-site; other site 1166130001974 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1166130001975 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1166130001976 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1166130001977 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1166130001978 AAA domain; Region: AAA_26; pfam13500 1166130001979 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1166130001980 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1166130001981 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1166130001982 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166130001983 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130001984 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1166130001985 dimerization interface [polypeptide binding]; other site 1166130001986 substrate binding pocket [chemical binding]; other site 1166130001987 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1166130001988 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130001989 putative substrate translocation pore; other site 1166130001990 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1166130001991 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1166130001992 active site 1166130001993 Zn binding site [ion binding]; other site 1166130001994 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1166130001995 CHASE4 domain; Region: CHASE4; pfam05228 1166130001996 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1166130001997 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166130001998 metal binding site [ion binding]; metal-binding site 1166130001999 active site 1166130002000 I-site; other site 1166130002001 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1166130002002 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 1166130002003 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 1166130002004 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1166130002005 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1166130002006 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1166130002007 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1166130002008 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1166130002009 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1166130002010 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1166130002011 HlyD family secretion protein; Region: HlyD_3; pfam13437 1166130002012 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1166130002013 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1166130002014 dimer interface [polypeptide binding]; other site 1166130002015 phosphorylation site [posttranslational modification] 1166130002016 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166130002017 ATP binding site [chemical binding]; other site 1166130002018 Mg2+ binding site [ion binding]; other site 1166130002019 G-X-G motif; other site 1166130002020 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1166130002021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130002022 active site 1166130002023 phosphorylation site [posttranslational modification] 1166130002024 intermolecular recognition site; other site 1166130002025 dimerization interface [polypeptide binding]; other site 1166130002026 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1166130002027 DNA binding site [nucleotide binding] 1166130002028 MltA-interacting protein MipA; Region: MipA; cl01504 1166130002029 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1166130002030 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166130002031 dimerization interface [polypeptide binding]; other site 1166130002032 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1166130002033 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166130002034 dimer interface [polypeptide binding]; other site 1166130002035 putative CheW interface [polypeptide binding]; other site 1166130002036 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1166130002037 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1166130002038 Catalytic site [active] 1166130002039 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 1166130002040 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1166130002041 active site 1166130002042 DNA binding site [nucleotide binding] 1166130002043 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1166130002044 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 1166130002045 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 1166130002046 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 1166130002047 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 1166130002048 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 1166130002049 dimer interaction site [polypeptide binding]; other site 1166130002050 substrate-binding tunnel; other site 1166130002051 active site 1166130002052 catalytic site [active] 1166130002053 substrate binding site [chemical binding]; other site 1166130002054 putative acyltransferase; Provisional; Region: PRK05790 1166130002055 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1166130002056 dimer interface [polypeptide binding]; other site 1166130002057 active site 1166130002058 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 1166130002059 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1166130002060 NAD(P) binding site [chemical binding]; other site 1166130002061 homotetramer interface [polypeptide binding]; other site 1166130002062 homodimer interface [polypeptide binding]; other site 1166130002063 active site 1166130002064 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 1166130002065 butyrate kinase; Provisional; Region: PRK03011 1166130002066 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 1166130002067 Smr domain; Region: Smr; pfam01713 1166130002068 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 1166130002069 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1166130002070 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1166130002071 DNA binding site [nucleotide binding] 1166130002072 active site 1166130002073 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 1166130002074 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1166130002075 ligand binding site [chemical binding]; other site 1166130002076 flexible hinge region; other site 1166130002077 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1166130002078 putative switch regulator; other site 1166130002079 non-specific DNA interactions [nucleotide binding]; other site 1166130002080 DNA binding site [nucleotide binding] 1166130002081 sequence specific DNA binding site [nucleotide binding]; other site 1166130002082 putative cAMP binding site [chemical binding]; other site 1166130002083 universal stress protein UspE; Provisional; Region: PRK11175 1166130002084 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1166130002085 Ligand Binding Site [chemical binding]; other site 1166130002086 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1166130002087 Ligand Binding Site [chemical binding]; other site 1166130002088 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1166130002089 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1166130002090 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 1166130002091 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1166130002092 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 1166130002093 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1166130002094 ligand binding site [chemical binding]; other site 1166130002095 homodimer interface [polypeptide binding]; other site 1166130002096 NAD(P) binding site [chemical binding]; other site 1166130002097 trimer interface B [polypeptide binding]; other site 1166130002098 trimer interface A [polypeptide binding]; other site 1166130002099 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1166130002100 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1166130002101 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1166130002102 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1166130002103 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1166130002104 Spore germination protein; Region: Spore_permease; cl17796 1166130002105 GlpM protein; Region: GlpM; pfam06942 1166130002106 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 1166130002107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130002108 active site 1166130002109 phosphorylation site [posttranslational modification] 1166130002110 intermolecular recognition site; other site 1166130002111 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1166130002112 DNA binding site [nucleotide binding] 1166130002113 sensor protein RstB; Provisional; Region: PRK10604 1166130002114 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166130002115 dimerization interface [polypeptide binding]; other site 1166130002116 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1166130002117 dimer interface [polypeptide binding]; other site 1166130002118 phosphorylation site [posttranslational modification] 1166130002119 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166130002120 ATP binding site [chemical binding]; other site 1166130002121 Mg2+ binding site [ion binding]; other site 1166130002122 G-X-G motif; other site 1166130002123 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 1166130002124 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1166130002125 Class II fumarases; Region: Fumarase_classII; cd01362 1166130002126 active site 1166130002127 tetramer interface [polypeptide binding]; other site 1166130002128 fumarate hydratase; Provisional; Region: PRK15389 1166130002129 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 1166130002130 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1166130002131 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1166130002132 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1166130002133 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1166130002134 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 1166130002135 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 1166130002136 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 1166130002137 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1166130002138 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1166130002139 active site turn [active] 1166130002140 phosphorylation site [posttranslational modification] 1166130002141 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1166130002142 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1166130002143 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130002144 homodimer interface [polypeptide binding]; other site 1166130002145 catalytic residue [active] 1166130002146 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1166130002147 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1166130002148 active site 1166130002149 purine riboside binding site [chemical binding]; other site 1166130002150 putative oxidoreductase; Provisional; Region: PRK11579 1166130002151 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1166130002152 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1166130002153 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 1166130002154 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 1166130002155 electron transport complex protein RsxA; Provisional; Region: PRK05151 1166130002156 electron transport complex protein RnfB; Provisional; Region: PRK05113 1166130002157 Putative Fe-S cluster; Region: FeS; cl17515 1166130002158 4Fe-4S binding domain; Region: Fer4; pfam00037 1166130002159 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 1166130002160 SLBB domain; Region: SLBB; pfam10531 1166130002161 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1166130002162 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 1166130002163 electron transport complex protein RnfG; Validated; Region: PRK01908 1166130002164 electron transport complex RsxE subunit; Provisional; Region: PRK12405 1166130002165 endonuclease III; Provisional; Region: PRK10702 1166130002166 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1166130002167 minor groove reading motif; other site 1166130002168 helix-hairpin-helix signature motif; other site 1166130002169 substrate binding pocket [chemical binding]; other site 1166130002170 active site 1166130002171 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1166130002172 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 1166130002173 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1166130002174 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1166130002175 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1166130002176 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1166130002177 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1166130002178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130002179 putative substrate translocation pore; other site 1166130002180 POT family; Region: PTR2; pfam00854 1166130002181 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1166130002182 C-terminal domain interface [polypeptide binding]; other site 1166130002183 GSH binding site (G-site) [chemical binding]; other site 1166130002184 dimer interface [polypeptide binding]; other site 1166130002185 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1166130002186 dimer interface [polypeptide binding]; other site 1166130002187 N-terminal domain interface [polypeptide binding]; other site 1166130002188 substrate binding pocket (H-site) [chemical binding]; other site 1166130002189 pyridoxamine kinase; Validated; Region: PRK05756 1166130002190 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1166130002191 dimer interface [polypeptide binding]; other site 1166130002192 pyridoxal binding site [chemical binding]; other site 1166130002193 ATP binding site [chemical binding]; other site 1166130002194 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1166130002195 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1166130002196 active site 1166130002197 HIGH motif; other site 1166130002198 dimer interface [polypeptide binding]; other site 1166130002199 KMSKS motif; other site 1166130002200 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1166130002201 RNA binding surface [nucleotide binding]; other site 1166130002202 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1166130002203 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1166130002204 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1166130002205 lysozyme inhibitor; Provisional; Region: PRK11372 1166130002206 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1166130002207 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1166130002208 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 1166130002209 transcriptional regulator SlyA; Provisional; Region: PRK03573 1166130002210 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1166130002211 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 1166130002212 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1166130002213 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1166130002214 HlyD family secretion protein; Region: HlyD_3; pfam13437 1166130002215 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1166130002216 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1166130002217 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1166130002218 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1166130002219 E-class dimer interface [polypeptide binding]; other site 1166130002220 P-class dimer interface [polypeptide binding]; other site 1166130002221 active site 1166130002222 Cu2+ binding site [ion binding]; other site 1166130002223 Zn2+ binding site [ion binding]; other site 1166130002224 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1166130002225 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1166130002226 active site 1166130002227 catalytic tetrad [active] 1166130002228 Predicted Fe-S protein [General function prediction only]; Region: COG3313 1166130002229 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1166130002230 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1166130002231 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1166130002232 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1166130002233 FMN binding site [chemical binding]; other site 1166130002234 active site 1166130002235 substrate binding site [chemical binding]; other site 1166130002236 catalytic residue [active] 1166130002237 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1166130002238 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1166130002239 dimer interface [polypeptide binding]; other site 1166130002240 active site 1166130002241 metal binding site [ion binding]; metal-binding site 1166130002242 glutathione binding site [chemical binding]; other site 1166130002243 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1166130002244 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 1166130002245 dimer interface [polypeptide binding]; other site 1166130002246 catalytic site [active] 1166130002247 putative active site [active] 1166130002248 putative substrate binding site [chemical binding]; other site 1166130002249 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1166130002250 putative GSH binding site [chemical binding]; other site 1166130002251 catalytic residues [active] 1166130002252 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1166130002253 NlpC/P60 family; Region: NLPC_P60; pfam00877 1166130002254 superoxide dismutase; Provisional; Region: PRK10543 1166130002255 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1166130002256 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1166130002257 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1166130002258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130002259 putative substrate translocation pore; other site 1166130002260 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 1166130002261 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1166130002262 DNA binding site [nucleotide binding] 1166130002263 domain linker motif; other site 1166130002264 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1166130002265 dimerization interface [polypeptide binding]; other site 1166130002266 ligand binding site [chemical binding]; other site 1166130002267 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1166130002268 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130002269 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1166130002270 dimerization interface [polypeptide binding]; other site 1166130002271 putative transporter; Provisional; Region: PRK11043 1166130002272 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130002273 putative substrate translocation pore; other site 1166130002274 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 1166130002275 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166130002276 S-adenosylmethionine binding site [chemical binding]; other site 1166130002277 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 1166130002278 Lumazine binding domain; Region: Lum_binding; pfam00677 1166130002279 Lumazine binding domain; Region: Lum_binding; pfam00677 1166130002280 multidrug efflux protein; Reviewed; Region: PRK01766 1166130002281 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1166130002282 cation binding site [ion binding]; other site 1166130002283 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 1166130002284 hypothetical protein; Provisional; Region: PRK09945 1166130002285 hypothetical protein; Provisional; Region: PRK09945 1166130002286 hypothetical protein; Provisional; Region: PRK09945 1166130002287 hypothetical protein; Provisional; Region: PRK09945 1166130002288 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1166130002289 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1166130002290 Autotransporter beta-domain; Region: Autotransporter; smart00869 1166130002291 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1166130002292 pyruvate kinase; Provisional; Region: PRK09206 1166130002293 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 1166130002294 domain interfaces; other site 1166130002295 active site 1166130002296 murein lipoprotein; Provisional; Region: PRK15396 1166130002297 L,D-transpeptidase; Provisional; Region: PRK10190 1166130002298 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1166130002299 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1166130002300 cysteine desufuration protein SufE; Provisional; Region: PRK09296 1166130002301 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1166130002302 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1166130002303 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1166130002304 catalytic residue [active] 1166130002305 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 1166130002306 FeS assembly protein SufD; Region: sufD; TIGR01981 1166130002307 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 1166130002308 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1166130002309 Walker A/P-loop; other site 1166130002310 ATP binding site [chemical binding]; other site 1166130002311 Q-loop/lid; other site 1166130002312 ABC transporter signature motif; other site 1166130002313 Walker B; other site 1166130002314 D-loop; other site 1166130002315 H-loop/switch region; other site 1166130002316 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1166130002317 putative ABC transporter; Region: ycf24; CHL00085 1166130002318 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 1166130002319 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1166130002320 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1166130002321 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1166130002322 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1166130002323 putative acyl-acceptor binding pocket; other site 1166130002324 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1166130002325 CoenzymeA binding site [chemical binding]; other site 1166130002326 subunit interaction site [polypeptide binding]; other site 1166130002327 PHB binding site; other site 1166130002328 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1166130002329 FAD binding domain; Region: FAD_binding_4; pfam01565 1166130002330 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1166130002331 putative inner membrane protein; Provisional; Region: PRK10983 1166130002332 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1166130002333 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1166130002334 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1166130002335 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1166130002336 putative symporter YagG; Provisional; Region: PRK09669 1166130002337 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1166130002338 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1166130002339 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1166130002340 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1166130002341 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1166130002342 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1166130002343 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 1166130002344 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1166130002345 Hemin uptake protein hemP; Region: hemP; cl10043 1166130002346 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1166130002347 hypothetical protein; Validated; Region: PRK00029 1166130002348 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 1166130002349 NlpC/P60 family; Region: NLPC_P60; pfam00877 1166130002350 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 1166130002351 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1166130002352 Walker A/P-loop; other site 1166130002353 ATP binding site [chemical binding]; other site 1166130002354 Q-loop/lid; other site 1166130002355 ABC transporter signature motif; other site 1166130002356 Walker B; other site 1166130002357 D-loop; other site 1166130002358 H-loop/switch region; other site 1166130002359 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1166130002360 catalytic residues [active] 1166130002361 dimer interface [polypeptide binding]; other site 1166130002362 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1166130002363 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1166130002364 ABC-ATPase subunit interface; other site 1166130002365 dimer interface [polypeptide binding]; other site 1166130002366 putative PBP binding regions; other site 1166130002367 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1166130002368 IHF dimer interface [polypeptide binding]; other site 1166130002369 IHF - DNA interface [nucleotide binding]; other site 1166130002370 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1166130002371 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1166130002372 putative tRNA-binding site [nucleotide binding]; other site 1166130002373 B3/4 domain; Region: B3_4; pfam03483 1166130002374 tRNA synthetase B5 domain; Region: B5; smart00874 1166130002375 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1166130002376 dimer interface [polypeptide binding]; other site 1166130002377 motif 1; other site 1166130002378 motif 3; other site 1166130002379 motif 2; other site 1166130002380 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1166130002381 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1166130002382 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1166130002383 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1166130002384 dimer interface [polypeptide binding]; other site 1166130002385 motif 1; other site 1166130002386 active site 1166130002387 motif 2; other site 1166130002388 motif 3; other site 1166130002389 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1166130002390 23S rRNA binding site [nucleotide binding]; other site 1166130002391 L21 binding site [polypeptide binding]; other site 1166130002392 L13 binding site [polypeptide binding]; other site 1166130002393 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1166130002394 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1166130002395 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1166130002396 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1166130002397 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1166130002398 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1166130002399 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1166130002400 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1166130002401 active site 1166130002402 dimer interface [polypeptide binding]; other site 1166130002403 motif 1; other site 1166130002404 motif 2; other site 1166130002405 motif 3; other site 1166130002406 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1166130002407 anticodon binding site; other site 1166130002408 hypothetical protein; Provisional; Region: PRK10292 1166130002409 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1166130002410 flagellin; Provisional; Region: PRK12806 1166130002411 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1166130002412 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 1166130002413 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 1166130002414 Phosphotransferase enzyme family; Region: APH; pfam01636 1166130002415 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1166130002416 active site 1166130002417 ATP binding site [chemical binding]; other site 1166130002418 YniB-like protein; Region: YniB; pfam14002 1166130002419 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 1166130002420 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1166130002421 motif II; other site 1166130002422 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 1166130002423 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1166130002424 NADP binding site [chemical binding]; other site 1166130002425 homodimer interface [polypeptide binding]; other site 1166130002426 active site 1166130002427 inner membrane protein; Provisional; Region: PRK11648 1166130002428 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1166130002429 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1166130002430 cell division modulator; Provisional; Region: PRK10113 1166130002431 hydroperoxidase II; Provisional; Region: katE; PRK11249 1166130002432 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1166130002433 tetramer interface [polypeptide binding]; other site 1166130002434 heme binding pocket [chemical binding]; other site 1166130002435 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1166130002436 domain interactions; other site 1166130002437 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 1166130002438 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1166130002439 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1166130002440 homodimer interface [polypeptide binding]; other site 1166130002441 NAD binding pocket [chemical binding]; other site 1166130002442 ATP binding pocket [chemical binding]; other site 1166130002443 Mg binding site [ion binding]; other site 1166130002444 active-site loop [active] 1166130002445 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 1166130002446 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1166130002447 GIY-YIG motif/motif A; other site 1166130002448 active site 1166130002449 catalytic site [active] 1166130002450 putative DNA binding site [nucleotide binding]; other site 1166130002451 metal binding site [ion binding]; metal-binding site 1166130002452 hypothetical protein; Provisional; Region: PRK11396 1166130002453 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1166130002454 dimer interface [polypeptide binding]; other site 1166130002455 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 1166130002456 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1166130002457 putative active site [active] 1166130002458 Zn binding site [ion binding]; other site 1166130002459 succinylarginine dihydrolase; Provisional; Region: PRK13281 1166130002460 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 1166130002461 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 1166130002462 NAD(P) binding site [chemical binding]; other site 1166130002463 catalytic residues [active] 1166130002464 arginine succinyltransferase; Provisional; Region: PRK10456 1166130002465 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1166130002466 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 1166130002467 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1166130002468 inhibitor-cofactor binding pocket; inhibition site 1166130002469 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130002470 catalytic residue [active] 1166130002471 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1166130002472 putative catalytic site [active] 1166130002473 putative phosphate binding site [ion binding]; other site 1166130002474 active site 1166130002475 metal binding site A [ion binding]; metal-binding site 1166130002476 DNA binding site [nucleotide binding] 1166130002477 putative AP binding site [nucleotide binding]; other site 1166130002478 putative metal binding site B [ion binding]; other site 1166130002479 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1166130002480 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1166130002481 active site residue [active] 1166130002482 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1166130002483 active site residue [active] 1166130002484 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1166130002485 active site 1166130002486 8-oxo-dGMP binding site [chemical binding]; other site 1166130002487 nudix motif; other site 1166130002488 metal binding site [ion binding]; metal-binding site 1166130002489 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 1166130002490 glutamate dehydrogenase; Provisional; Region: PRK09414 1166130002491 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1166130002492 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1166130002493 NAD(P) binding site [chemical binding]; other site 1166130002494 DNA topoisomerase III; Provisional; Region: PRK07726 1166130002495 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1166130002496 active site 1166130002497 putative interdomain interaction site [polypeptide binding]; other site 1166130002498 putative metal-binding site [ion binding]; other site 1166130002499 putative nucleotide binding site [chemical binding]; other site 1166130002500 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1166130002501 domain I; other site 1166130002502 DNA binding groove [nucleotide binding] 1166130002503 phosphate binding site [ion binding]; other site 1166130002504 domain II; other site 1166130002505 domain III; other site 1166130002506 nucleotide binding site [chemical binding]; other site 1166130002507 catalytic site [active] 1166130002508 domain IV; other site 1166130002509 selenophosphate synthetase; Provisional; Region: PRK00943 1166130002510 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1166130002511 dimerization interface [polypeptide binding]; other site 1166130002512 putative ATP binding site [chemical binding]; other site 1166130002513 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 1166130002514 active site 1166130002515 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1166130002516 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1166130002517 putative FMN binding site [chemical binding]; other site 1166130002518 protease 4; Provisional; Region: PRK10949 1166130002519 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1166130002520 tandem repeat interface [polypeptide binding]; other site 1166130002521 oligomer interface [polypeptide binding]; other site 1166130002522 active site residues [active] 1166130002523 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 1166130002524 tandem repeat interface [polypeptide binding]; other site 1166130002525 oligomer interface [polypeptide binding]; other site 1166130002526 active site residues [active] 1166130002527 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1166130002528 active site 1166130002529 homodimer interface [polypeptide binding]; other site 1166130002530 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1166130002531 Isochorismatase family; Region: Isochorismatase; pfam00857 1166130002532 catalytic triad [active] 1166130002533 metal binding site [ion binding]; metal-binding site 1166130002534 conserved cis-peptide bond; other site 1166130002535 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 1166130002536 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1166130002537 SelR domain; Region: SelR; pfam01641 1166130002538 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 1166130002539 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1166130002540 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1166130002541 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1166130002542 active site 1166130002543 phosphate binding residues; other site 1166130002544 catalytic residues [active] 1166130002545 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1166130002546 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1166130002547 active site 1166130002548 catalytic tetrad [active] 1166130002549 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1166130002550 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 1166130002551 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 1166130002552 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1166130002553 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1166130002554 acyl-activating enzyme (AAE) consensus motif; other site 1166130002555 AMP binding site [chemical binding]; other site 1166130002556 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1166130002557 PrkA family serine protein kinase; Provisional; Region: PRK15455 1166130002558 AAA ATPase domain; Region: AAA_16; pfam13191 1166130002559 Walker A motif; other site 1166130002560 ATP binding site [chemical binding]; other site 1166130002561 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1166130002562 hypothetical protein; Provisional; Region: PRK05325 1166130002563 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 1166130002564 putative deacylase active site [active] 1166130002565 Predicted membrane protein [Function unknown]; Region: COG2707 1166130002566 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1166130002567 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130002568 dimer interface [polypeptide binding]; other site 1166130002569 conserved gate region; other site 1166130002570 putative PBP binding loops; other site 1166130002571 ABC-ATPase subunit interface; other site 1166130002572 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130002573 dimer interface [polypeptide binding]; other site 1166130002574 conserved gate region; other site 1166130002575 putative PBP binding loops; other site 1166130002576 ABC-ATPase subunit interface; other site 1166130002577 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1166130002578 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1166130002579 Walker A/P-loop; other site 1166130002580 ATP binding site [chemical binding]; other site 1166130002581 Q-loop/lid; other site 1166130002582 ABC transporter signature motif; other site 1166130002583 Walker B; other site 1166130002584 D-loop; other site 1166130002585 H-loop/switch region; other site 1166130002586 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1166130002587 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166130002588 substrate binding pocket [chemical binding]; other site 1166130002589 membrane-bound complex binding site; other site 1166130002590 hinge residues; other site 1166130002591 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1166130002592 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130002593 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1166130002594 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130002595 putative substrate translocation pore; other site 1166130002596 hypothetical protein; Validated; Region: PRK06186 1166130002597 conserved cys residue [active] 1166130002598 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1166130002599 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1166130002600 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 1166130002601 Domain of unknown function (DUF333); Region: DUF333; pfam03891 1166130002602 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1166130002603 GAF domain; Region: GAF; pfam01590 1166130002604 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1166130002605 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166130002606 metal binding site [ion binding]; metal-binding site 1166130002607 active site 1166130002608 I-site; other site 1166130002609 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1166130002610 GAF domain; Region: GAF; pfam01590 1166130002611 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166130002612 metal binding site [ion binding]; metal-binding site 1166130002613 I-site; other site 1166130002614 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1166130002615 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1166130002616 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166130002617 dimerization interface [polypeptide binding]; other site 1166130002618 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166130002619 dimer interface [polypeptide binding]; other site 1166130002620 putative CheW interface [polypeptide binding]; other site 1166130002621 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 1166130002622 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1166130002623 PAS domain; Region: PAS_9; pfam13426 1166130002624 putative active site [active] 1166130002625 heme pocket [chemical binding]; other site 1166130002626 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1166130002627 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166130002628 dimer interface [polypeptide binding]; other site 1166130002629 putative CheW interface [polypeptide binding]; other site 1166130002630 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166130002631 Coenzyme A binding pocket [chemical binding]; other site 1166130002632 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 1166130002633 active site 1166130002634 P-loop; other site 1166130002635 phosphorylation site [posttranslational modification] 1166130002636 leucine export protein LeuE; Provisional; Region: PRK10958 1166130002637 DinI-like family; Region: DinI; pfam06183 1166130002638 TolA C-terminal; Region: TolA; pfam06519 1166130002639 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 1166130002640 Transposase; Region: HTH_Tnp_1; pfam01527 1166130002641 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1166130002642 HTH-like domain; Region: HTH_21; pfam13276 1166130002643 Integrase core domain; Region: rve; pfam00665 1166130002644 Integrase core domain; Region: rve_3; pfam13683 1166130002645 hypothetical protein; Provisional; Region: PRK05170 1166130002646 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1166130002647 hypothetical protein; Provisional; Region: PRK10691 1166130002648 YcgL domain; Region: YcgL; cl01189 1166130002649 septum formation inhibitor; Reviewed; Region: minC; PRK03511 1166130002650 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1166130002651 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1166130002652 cell division inhibitor MinD; Provisional; Region: PRK10818 1166130002653 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1166130002654 Switch I; other site 1166130002655 Switch II; other site 1166130002656 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 1166130002657 ribonuclease D; Provisional; Region: PRK10829 1166130002658 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1166130002659 catalytic site [active] 1166130002660 putative active site [active] 1166130002661 putative substrate binding site [chemical binding]; other site 1166130002662 Helicase and RNase D C-terminal; Region: HRDC; smart00341 1166130002663 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 1166130002664 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1166130002665 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1166130002666 acyl-activating enzyme (AAE) consensus motif; other site 1166130002667 putative AMP binding site [chemical binding]; other site 1166130002668 putative active site [active] 1166130002669 putative CoA binding site [chemical binding]; other site 1166130002670 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 1166130002671 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1166130002672 Glycoprotease family; Region: Peptidase_M22; pfam00814 1166130002673 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1166130002674 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1166130002675 DEAD_2; Region: DEAD_2; pfam06733 1166130002676 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1166130002677 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1166130002678 homotrimer interaction site [polypeptide binding]; other site 1166130002679 putative active site [active] 1166130002680 hypothetical protein; Provisional; Region: PRK05114 1166130002681 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 1166130002682 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1166130002683 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1166130002684 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1166130002685 putative active site [active] 1166130002686 putative CoA binding site [chemical binding]; other site 1166130002687 nudix motif; other site 1166130002688 metal binding site [ion binding]; metal-binding site 1166130002689 L-serine deaminase; Provisional; Region: PRK15023 1166130002690 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1166130002691 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1166130002692 phage resistance protein; Provisional; Region: PRK10551 1166130002693 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1166130002694 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1166130002695 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1166130002696 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1166130002697 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1166130002698 Transporter associated domain; Region: CorC_HlyC; smart01091 1166130002699 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1166130002700 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1166130002701 active pocket/dimerization site; other site 1166130002702 active site 1166130002703 phosphorylation site [posttranslational modification] 1166130002704 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1166130002705 active site 1166130002706 phosphorylation site [posttranslational modification] 1166130002707 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1166130002708 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 1166130002709 hypothetical protein; Provisional; Region: PRK02913 1166130002710 hypothetical protein; Provisional; Region: PRK11469 1166130002711 Domain of unknown function DUF; Region: DUF204; pfam02659 1166130002712 Domain of unknown function DUF; Region: DUF204; pfam02659 1166130002713 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1166130002714 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1166130002715 S-adenosylmethionine binding site [chemical binding]; other site 1166130002716 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1166130002717 DNA-binding site [nucleotide binding]; DNA binding site 1166130002718 RNA-binding motif; other site 1166130002719 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1166130002720 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1166130002721 YebO-like protein; Region: YebO; pfam13974 1166130002722 YobH-like protein; Region: YobH; pfam13996 1166130002723 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 1166130002724 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1166130002725 dimerization interface [polypeptide binding]; other site 1166130002726 putative Zn2+ binding site [ion binding]; other site 1166130002727 putative DNA binding site [nucleotide binding]; other site 1166130002728 Bacterial transcriptional regulator; Region: IclR; pfam01614 1166130002729 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1166130002730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130002731 putative substrate translocation pore; other site 1166130002732 heat shock protein HtpX; Provisional; Region: PRK05457 1166130002733 carboxy-terminal protease; Provisional; Region: PRK11186 1166130002734 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1166130002735 protein binding site [polypeptide binding]; other site 1166130002736 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1166130002737 Catalytic dyad [active] 1166130002738 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 1166130002739 ProP expression regulator; Provisional; Region: PRK04950 1166130002740 ProQ/FINO family; Region: ProQ; pfam04352 1166130002741 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1166130002742 GAF domain; Region: GAF_2; pfam13185 1166130002743 Paraquat-inducible protein A; Region: PqiA; pfam04403 1166130002744 Paraquat-inducible protein A; Region: PqiA; pfam04403 1166130002745 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1166130002746 mce related protein; Region: MCE; pfam02470 1166130002747 mce related protein; Region: MCE; pfam02470 1166130002748 mce related protein; Region: MCE; pfam02470 1166130002749 mce related protein; Region: MCE; pfam02470 1166130002750 mce related protein; Region: MCE; pfam02470 1166130002751 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 1166130002752 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166130002753 S-adenosylmethionine binding site [chemical binding]; other site 1166130002754 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 1166130002755 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 1166130002756 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 1166130002757 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 1166130002758 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1166130002759 active site 1166130002760 metal binding site [ion binding]; metal-binding site 1166130002761 Protein of unknown function (DUF535); Region: DUF535; pfam04393 1166130002762 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 1166130002763 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1166130002764 CopC domain; Region: CopC; cl01012 1166130002765 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 1166130002766 exodeoxyribonuclease X; Provisional; Region: PRK07983 1166130002767 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1166130002768 active site 1166130002769 catalytic site [active] 1166130002770 substrate binding site [chemical binding]; other site 1166130002771 protease 2; Provisional; Region: PRK10115 1166130002772 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1166130002773 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 1166130002774 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 1166130002775 putative metal binding site [ion binding]; other site 1166130002776 hypothetical protein; Provisional; Region: PRK13680 1166130002777 YebG protein; Region: YebG; cl01217 1166130002778 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1166130002779 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1166130002780 ATP-grasp domain; Region: ATP-grasp; pfam02222 1166130002781 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1166130002782 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1166130002783 active site 1166130002784 intersubunit interface [polypeptide binding]; other site 1166130002785 catalytic residue [active] 1166130002786 phosphogluconate dehydratase; Validated; Region: PRK09054 1166130002787 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1166130002788 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1166130002789 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1166130002790 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1166130002791 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1166130002792 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1166130002793 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1166130002794 putative active site [active] 1166130002795 pyruvate kinase; Provisional; Region: PRK05826 1166130002796 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1166130002797 domain interfaces; other site 1166130002798 active site 1166130002799 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1166130002800 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1166130002801 putative acyl-acceptor binding pocket; other site 1166130002802 putative peptidase; Provisional; Region: PRK11649 1166130002803 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1166130002804 Peptidase family M23; Region: Peptidase_M23; pfam01551 1166130002805 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 1166130002806 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 1166130002807 metal binding site [ion binding]; metal-binding site 1166130002808 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 1166130002809 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1166130002810 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1166130002811 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1166130002812 ABC-ATPase subunit interface; other site 1166130002813 dimer interface [polypeptide binding]; other site 1166130002814 putative PBP binding regions; other site 1166130002815 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1166130002816 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166130002817 Walker A motif; other site 1166130002818 ATP binding site [chemical binding]; other site 1166130002819 Walker B motif; other site 1166130002820 arginine finger; other site 1166130002821 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1166130002822 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1166130002823 RuvA N terminal domain; Region: RuvA_N; pfam01330 1166130002824 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1166130002825 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 1166130002826 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1166130002827 putative NAD(P) binding site [chemical binding]; other site 1166130002828 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1166130002829 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1166130002830 salt bridge; other site 1166130002831 non-specific DNA binding site [nucleotide binding]; other site 1166130002832 sequence-specific DNA binding site [nucleotide binding]; other site 1166130002833 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1166130002834 active site 1166130002835 putative DNA-binding cleft [nucleotide binding]; other site 1166130002836 dimer interface [polypeptide binding]; other site 1166130002837 hypothetical protein; Validated; Region: PRK00110 1166130002838 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 1166130002839 nudix motif; other site 1166130002840 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1166130002841 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1166130002842 dimer interface [polypeptide binding]; other site 1166130002843 anticodon binding site; other site 1166130002844 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1166130002845 homodimer interface [polypeptide binding]; other site 1166130002846 motif 1; other site 1166130002847 active site 1166130002848 motif 2; other site 1166130002849 GAD domain; Region: GAD; pfam02938 1166130002850 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1166130002851 active site 1166130002852 motif 3; other site 1166130002853 Isochorismatase family; Region: Isochorismatase; pfam00857 1166130002854 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1166130002855 catalytic triad [active] 1166130002856 conserved cis-peptide bond; other site 1166130002857 hypothetical protein; Provisional; Region: PRK10302 1166130002858 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 1166130002859 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166130002860 S-adenosylmethionine binding site [chemical binding]; other site 1166130002861 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1166130002862 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166130002863 S-adenosylmethionine binding site [chemical binding]; other site 1166130002864 copper homeostasis protein CutC; Provisional; Region: PRK11572 1166130002865 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 1166130002866 putative metal binding site [ion binding]; other site 1166130002867 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 1166130002868 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1166130002869 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1166130002870 active site 1166130002871 HIGH motif; other site 1166130002872 KMSK motif region; other site 1166130002873 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1166130002874 tRNA binding surface [nucleotide binding]; other site 1166130002875 anticodon binding site; other site 1166130002876 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1166130002877 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1166130002878 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130002879 Flagellar protein FlhE; Region: FlhE; pfam06366 1166130002880 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1166130002881 FHIPEP family; Region: FHIPEP; pfam00771 1166130002882 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1166130002883 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1166130002884 CAAX protease self-immunity; Region: Abi; pfam02517 1166130002885 chemotaxis regulator CheZ; Provisional; Region: PRK11166 1166130002886 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1166130002887 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130002888 active site 1166130002889 phosphorylation site [posttranslational modification] 1166130002890 intermolecular recognition site; other site 1166130002891 dimerization interface [polypeptide binding]; other site 1166130002892 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1166130002893 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130002894 active site 1166130002895 phosphorylation site [posttranslational modification] 1166130002896 intermolecular recognition site; other site 1166130002897 dimerization interface [polypeptide binding]; other site 1166130002898 CheB methylesterase; Region: CheB_methylest; pfam01339 1166130002899 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 1166130002900 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1166130002901 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166130002902 S-adenosylmethionine binding site [chemical binding]; other site 1166130002903 methyl-accepting protein IV; Provisional; Region: PRK09793 1166130002904 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1166130002905 dimer interface [polypeptide binding]; other site 1166130002906 ligand binding site [chemical binding]; other site 1166130002907 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166130002908 dimerization interface [polypeptide binding]; other site 1166130002909 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166130002910 dimer interface [polypeptide binding]; other site 1166130002911 putative CheW interface [polypeptide binding]; other site 1166130002912 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 1166130002913 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1166130002914 dimer interface [polypeptide binding]; other site 1166130002915 ligand binding site [chemical binding]; other site 1166130002916 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166130002917 dimerization interface [polypeptide binding]; other site 1166130002918 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166130002919 dimer interface [polypeptide binding]; other site 1166130002920 putative CheW interface [polypeptide binding]; other site 1166130002921 Spore Coat Protein U domain; Region: SCPU; pfam05229 1166130002922 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1166130002923 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1166130002924 PapC C-terminal domain; Region: PapC_C; pfam13953 1166130002925 fimbrial chaperone protein StbB; Provisional; Region: PRK15249 1166130002926 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1166130002927 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1166130002928 Spore Coat Protein U domain; Region: SCPU; pfam05229 1166130002929 Spore Coat Protein U domain; Region: SCPU; pfam05229 1166130002930 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1166130002931 putative CheA interaction surface; other site 1166130002932 chemotaxis protein CheA; Provisional; Region: PRK10547 1166130002933 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1166130002934 putative binding surface; other site 1166130002935 active site 1166130002936 CheY binding; Region: CheY-binding; pfam09078 1166130002937 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1166130002938 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166130002939 ATP binding site [chemical binding]; other site 1166130002940 Mg2+ binding site [ion binding]; other site 1166130002941 G-X-G motif; other site 1166130002942 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1166130002943 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1166130002944 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 1166130002945 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1166130002946 ligand binding site [chemical binding]; other site 1166130002947 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1166130002948 flagellar motor protein MotA; Validated; Region: PRK09110 1166130002949 transcriptional activator FlhC; Provisional; Region: PRK12722 1166130002950 transcriptional activator FlhD; Provisional; Region: PRK02909 1166130002951 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1166130002952 Ligand Binding Site [chemical binding]; other site 1166130002953 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1166130002954 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1166130002955 active site 1166130002956 homotetramer interface [polypeptide binding]; other site 1166130002957 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 1166130002958 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1166130002959 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1166130002960 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1166130002961 TM-ABC transporter signature motif; other site 1166130002962 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 1166130002963 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1166130002964 Walker A/P-loop; other site 1166130002965 ATP binding site [chemical binding]; other site 1166130002966 Q-loop/lid; other site 1166130002967 ABC transporter signature motif; other site 1166130002968 Walker B; other site 1166130002969 D-loop; other site 1166130002970 H-loop/switch region; other site 1166130002971 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1166130002972 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 1166130002973 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 1166130002974 ligand binding site [chemical binding]; other site 1166130002975 DJ-1 family protein; Region: not_thiJ; TIGR01383 1166130002976 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1166130002977 conserved cys residue [active] 1166130002978 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 1166130002979 putative transporter; Provisional; Region: PRK10504 1166130002980 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130002981 putative substrate translocation pore; other site 1166130002982 hypothetical protein; Provisional; Region: PRK09273 1166130002983 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 1166130002984 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 1166130002985 YecR-like lipoprotein; Region: YecR; pfam13992 1166130002986 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1166130002987 Ferritin-like domain; Region: Ferritin; pfam00210 1166130002988 ferroxidase diiron center [ion binding]; other site 1166130002989 probable metal-binding protein; Region: matur_matur; TIGR03853 1166130002990 tyrosine transporter TyrP; Provisional; Region: PRK15132 1166130002991 aromatic amino acid transport protein; Region: araaP; TIGR00837 1166130002992 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 1166130002993 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1166130002994 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1166130002995 GIY-YIG motif/motif A; other site 1166130002996 active site 1166130002997 catalytic site [active] 1166130002998 putative DNA binding site [nucleotide binding]; other site 1166130002999 metal binding site [ion binding]; metal-binding site 1166130003000 UvrB/uvrC motif; Region: UVR; pfam02151 1166130003001 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1166130003002 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1166130003003 response regulator; Provisional; Region: PRK09483 1166130003004 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130003005 active site 1166130003006 phosphorylation site [posttranslational modification] 1166130003007 intermolecular recognition site; other site 1166130003008 dimerization interface [polypeptide binding]; other site 1166130003009 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1166130003010 DNA binding residues [nucleotide binding] 1166130003011 dimerization interface [polypeptide binding]; other site 1166130003012 hypothetical protein; Provisional; Region: PRK10613 1166130003013 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 1166130003014 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1166130003015 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1166130003016 DNA binding residues [nucleotide binding] 1166130003017 dimerization interface [polypeptide binding]; other site 1166130003018 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 1166130003019 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1166130003020 Walker A/P-loop; other site 1166130003021 ATP binding site [chemical binding]; other site 1166130003022 Q-loop/lid; other site 1166130003023 ABC transporter signature motif; other site 1166130003024 Walker B; other site 1166130003025 D-loop; other site 1166130003026 H-loop/switch region; other site 1166130003027 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1166130003028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130003029 dimer interface [polypeptide binding]; other site 1166130003030 conserved gate region; other site 1166130003031 putative PBP binding loops; other site 1166130003032 ABC-ATPase subunit interface; other site 1166130003033 D-cysteine desulfhydrase; Validated; Region: PRK03910 1166130003034 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 1166130003035 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130003036 catalytic residue [active] 1166130003037 cystine transporter subunit; Provisional; Region: PRK11260 1166130003038 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166130003039 substrate binding pocket [chemical binding]; other site 1166130003040 membrane-bound complex binding site; other site 1166130003041 hinge residues; other site 1166130003042 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 1166130003043 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 1166130003044 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1166130003045 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1166130003046 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1166130003047 DNA binding residues [nucleotide binding] 1166130003048 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1166130003049 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1166130003050 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1166130003051 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1166130003052 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1166130003053 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1166130003054 inhibitor-cofactor binding pocket; inhibition site 1166130003055 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130003056 catalytic residue [active] 1166130003057 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1166130003058 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1166130003059 active site 1166130003060 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1166130003061 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1166130003062 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1166130003063 Probable Catalytic site; other site 1166130003064 metal-binding site 1166130003065 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 1166130003066 flagellin; Reviewed; Region: PRK08869 1166130003067 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1166130003068 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1166130003069 flagellin; Provisional; Region: PRK12802 1166130003070 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1166130003071 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1166130003072 flagellin; Provisional; Region: PRK12802 1166130003073 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1166130003074 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1166130003075 flagellar capping protein; Reviewed; Region: fliD; PRK08032 1166130003076 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1166130003077 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1166130003078 flagellar protein FliS; Validated; Region: fliS; PRK05685 1166130003079 Flagellar protein FliT; Region: FliT; cl05125 1166130003080 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 1166130003081 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 1166130003082 active site 1166130003083 Na/Ca binding site [ion binding]; other site 1166130003084 catalytic site [active] 1166130003085 lipoprotein; Provisional; Region: PRK10397 1166130003086 putative inner membrane protein; Provisional; Region: PRK11099 1166130003087 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 1166130003088 CPxP motif; other site 1166130003089 diguanylate cyclase; Provisional; Region: PRK09894 1166130003090 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 1166130003091 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166130003092 metal binding site [ion binding]; metal-binding site 1166130003093 active site 1166130003094 I-site; other site 1166130003095 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1166130003096 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 1166130003097 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1166130003098 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 1166130003099 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1166130003100 flagellar motor switch protein FliG; Region: fliG; TIGR00207 1166130003101 FliG C-terminal domain; Region: FliG_C; pfam01706 1166130003102 flagellar assembly protein H; Validated; Region: fliH; PRK05687 1166130003103 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 1166130003104 Flagellar assembly protein FliH; Region: FliH; pfam02108 1166130003105 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 1166130003106 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1166130003107 Walker A motif/ATP binding site; other site 1166130003108 Walker B motif; other site 1166130003109 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 1166130003110 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 1166130003111 flagellar hook-length control protein; Provisional; Region: PRK10118 1166130003112 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 1166130003113 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 1166130003114 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1166130003115 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1166130003116 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 1166130003117 flagellar motor switch protein; Validated; Region: fliN; PRK05698 1166130003118 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 1166130003119 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1166130003120 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1166130003121 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1166130003122 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 1166130003123 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1166130003124 DNA binding residues [nucleotide binding] 1166130003125 dimerization interface [polypeptide binding]; other site 1166130003126 hypothetical protein; Provisional; Region: PRK10708 1166130003127 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 1166130003128 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 1166130003129 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1166130003130 active site 1166130003131 motif I; other site 1166130003132 motif II; other site 1166130003133 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 1166130003134 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166130003135 metal binding site [ion binding]; metal-binding site 1166130003136 active site 1166130003137 I-site; other site 1166130003138 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 1166130003139 hypothetical protein; Provisional; Region: PRK10062 1166130003140 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1166130003141 EamA-like transporter family; Region: EamA; pfam00892 1166130003142 EamA-like transporter family; Region: EamA; pfam00892 1166130003143 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1166130003144 additional DNA contacts [nucleotide binding]; other site 1166130003145 mismatch recognition site; other site 1166130003146 active site 1166130003147 zinc binding site [ion binding]; other site 1166130003148 DNA intercalation site [nucleotide binding]; other site 1166130003149 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1166130003150 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1166130003151 Zn2+ binding site [ion binding]; other site 1166130003152 Mg2+ binding site [ion binding]; other site 1166130003153 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 1166130003154 short chain dehydrogenase; Provisional; Region: PRK06523 1166130003155 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1166130003156 NAD(P) binding site [chemical binding]; other site 1166130003157 active site 1166130003158 SnoaL-like domain; Region: SnoaL_2; pfam12680 1166130003159 Predicted transcriptional regulators [Transcription]; Region: COG1733 1166130003160 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1166130003161 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1166130003162 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166130003163 Coenzyme A binding pocket [chemical binding]; other site 1166130003164 chorismate mutase; Provisional; Region: PRK08055 1166130003165 shikimate transporter; Provisional; Region: PRK09952 1166130003166 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130003167 putative substrate translocation pore; other site 1166130003168 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 1166130003169 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1166130003170 dimerization interface [polypeptide binding]; other site 1166130003171 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 1166130003172 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130003173 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1166130003174 putative dimerization interface [polypeptide binding]; other site 1166130003175 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1166130003176 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1166130003177 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166130003178 dimer interface [polypeptide binding]; other site 1166130003179 putative CheW interface [polypeptide binding]; other site 1166130003180 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 1166130003181 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130003182 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1166130003183 dimerization interface [polypeptide binding]; other site 1166130003184 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1166130003185 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166130003186 Coenzyme A binding pocket [chemical binding]; other site 1166130003187 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1166130003188 Putative motility protein; Region: YjfB_motility; pfam14070 1166130003189 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1166130003190 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1166130003191 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1166130003192 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1166130003193 NADP binding site [chemical binding]; other site 1166130003194 dimer interface [polypeptide binding]; other site 1166130003195 AMP nucleosidase; Provisional; Region: PRK08292 1166130003196 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1166130003197 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1166130003198 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1166130003199 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1166130003200 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 1166130003201 active site 1166130003202 MATE family multidrug exporter; Provisional; Region: PRK10189 1166130003203 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 1166130003204 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1166130003205 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130003206 putative substrate translocation pore; other site 1166130003207 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1166130003208 putative active site pocket [active] 1166130003209 dimerization interface [polypeptide binding]; other site 1166130003210 putative catalytic residue [active] 1166130003211 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 1166130003212 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 1166130003213 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1166130003214 DNA-binding site [nucleotide binding]; DNA binding site 1166130003215 RNA-binding motif; other site 1166130003216 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1166130003217 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1166130003218 L,D-transpeptidase; Provisional; Region: PRK10190 1166130003219 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1166130003220 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 1166130003221 elongation factor G; Reviewed; Region: PRK00007 1166130003222 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1166130003223 G1 box; other site 1166130003224 putative GEF interaction site [polypeptide binding]; other site 1166130003225 GTP/Mg2+ binding site [chemical binding]; other site 1166130003226 Switch I region; other site 1166130003227 G2 box; other site 1166130003228 G3 box; other site 1166130003229 Switch II region; other site 1166130003230 G4 box; other site 1166130003231 G5 box; other site 1166130003232 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1166130003233 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1166130003234 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1166130003235 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1166130003236 dimerization interface [polypeptide binding]; other site 1166130003237 putative DNA binding site [nucleotide binding]; other site 1166130003238 putative Zn2+ binding site [ion binding]; other site 1166130003239 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1166130003240 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1166130003241 putative dimer interface [polypeptide binding]; other site 1166130003242 active site pocket [active] 1166130003243 putative cataytic base [active] 1166130003244 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1166130003245 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1166130003246 homotrimer interface [polypeptide binding]; other site 1166130003247 Walker A motif; other site 1166130003248 GTP binding site [chemical binding]; other site 1166130003249 Walker B motif; other site 1166130003250 cobyric acid synthase; Provisional; Region: PRK00784 1166130003251 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1166130003252 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1166130003253 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1166130003254 catalytic triad [active] 1166130003255 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1166130003256 active site 1166130003257 SAM binding site [chemical binding]; other site 1166130003258 homodimer interface [polypeptide binding]; other site 1166130003259 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 1166130003260 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 1166130003261 active site 1166130003262 C-terminal domain interface [polypeptide binding]; other site 1166130003263 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 1166130003264 active site 1166130003265 N-terminal domain interface [polypeptide binding]; other site 1166130003266 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1166130003267 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 1166130003268 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1166130003269 active site 1166130003270 SAM binding site [chemical binding]; other site 1166130003271 homodimer interface [polypeptide binding]; other site 1166130003272 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 1166130003273 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 1166130003274 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 1166130003275 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1166130003276 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1166130003277 active site 1166130003278 SAM binding site [chemical binding]; other site 1166130003279 homodimer interface [polypeptide binding]; other site 1166130003280 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 1166130003281 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166130003282 S-adenosylmethionine binding site [chemical binding]; other site 1166130003283 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1166130003284 active site 1166130003285 putative homodimer interface [polypeptide binding]; other site 1166130003286 SAM binding site [chemical binding]; other site 1166130003287 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 1166130003288 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286 1166130003289 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1166130003290 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1166130003291 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1166130003292 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1166130003293 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1166130003294 catalytic triad [active] 1166130003295 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 1166130003296 hypothetical protein; Provisional; Region: PRK05423 1166130003297 Predicted membrane protein [Function unknown]; Region: COG1289 1166130003298 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1166130003299 DNA gyrase inhibitor; Provisional; Region: PRK10016 1166130003300 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 1166130003301 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1166130003302 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1166130003303 exonuclease I; Provisional; Region: sbcB; PRK11779 1166130003304 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 1166130003305 active site 1166130003306 catalytic site [active] 1166130003307 substrate binding site [chemical binding]; other site 1166130003308 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 1166130003309 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1166130003310 CPxP motif; other site 1166130003311 Sulphur transport; Region: Sulf_transp; pfam04143 1166130003312 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 1166130003313 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1166130003314 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1166130003315 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1166130003316 putative NAD(P) binding site [chemical binding]; other site 1166130003317 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1166130003318 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1166130003319 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1166130003320 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1166130003321 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1166130003322 NAD binding site [chemical binding]; other site 1166130003323 dimerization interface [polypeptide binding]; other site 1166130003324 product binding site; other site 1166130003325 substrate binding site [chemical binding]; other site 1166130003326 zinc binding site [ion binding]; other site 1166130003327 catalytic residues [active] 1166130003328 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 1166130003329 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1166130003330 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130003331 homodimer interface [polypeptide binding]; other site 1166130003332 catalytic residue [active] 1166130003333 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 1166130003334 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1166130003335 active site 1166130003336 motif I; other site 1166130003337 motif II; other site 1166130003338 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1166130003339 putative active site pocket [active] 1166130003340 4-fold oligomerization interface [polypeptide binding]; other site 1166130003341 metal binding residues [ion binding]; metal-binding site 1166130003342 3-fold/trimer interface [polypeptide binding]; other site 1166130003343 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 1166130003344 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1166130003345 putative active site [active] 1166130003346 oxyanion strand; other site 1166130003347 catalytic triad [active] 1166130003348 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1166130003349 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1166130003350 catalytic residues [active] 1166130003351 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1166130003352 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1166130003353 substrate binding site [chemical binding]; other site 1166130003354 glutamase interaction surface [polypeptide binding]; other site 1166130003355 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1166130003356 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1166130003357 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1166130003358 metal binding site [ion binding]; metal-binding site 1166130003359 chain length determinant protein WzzB; Provisional; Region: PRK15471 1166130003360 Chain length determinant protein; Region: Wzz; cl15801 1166130003361 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1166130003362 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 1166130003363 putative NAD(P) binding site [chemical binding]; other site 1166130003364 active site 1166130003365 putative substrate binding site [chemical binding]; other site 1166130003366 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 1166130003367 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1166130003368 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1166130003369 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1166130003370 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1166130003371 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1166130003372 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1166130003373 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 1166130003374 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1166130003375 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1166130003376 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1166130003377 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 1166130003378 active site 1166130003379 substrate binding site [chemical binding]; other site 1166130003380 metal binding site [ion binding]; metal-binding site 1166130003381 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1166130003382 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1166130003383 Substrate binding site; other site 1166130003384 Cupin domain; Region: Cupin_2; cl17218 1166130003385 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 1166130003386 putative ADP-binding pocket [chemical binding]; other site 1166130003387 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1166130003388 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1166130003389 active site 1166130003390 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1166130003391 trimer interface [polypeptide binding]; other site 1166130003392 active site 1166130003393 substrate binding site [chemical binding]; other site 1166130003394 CoA binding site [chemical binding]; other site 1166130003395 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1166130003396 O-Antigen ligase; Region: Wzy_C; pfam04932 1166130003397 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1166130003398 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1166130003399 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1166130003400 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1166130003401 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1166130003402 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1166130003403 inhibitor-cofactor binding pocket; inhibition site 1166130003404 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130003405 catalytic residue [active] 1166130003406 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1166130003407 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1166130003408 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1166130003409 substrate binding site; other site 1166130003410 tetramer interface; other site 1166130003411 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 1166130003412 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1166130003413 NADP binding site [chemical binding]; other site 1166130003414 active site 1166130003415 putative substrate binding site [chemical binding]; other site 1166130003416 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 1166130003417 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1166130003418 NAD binding site [chemical binding]; other site 1166130003419 substrate binding site [chemical binding]; other site 1166130003420 homodimer interface [polypeptide binding]; other site 1166130003421 active site 1166130003422 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1166130003423 active site 1166130003424 tetramer interface; other site 1166130003425 putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123 1166130003426 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 1166130003427 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 1166130003428 putative ADP-binding pocket [chemical binding]; other site 1166130003429 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 1166130003430 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 1166130003431 colanic acid exporter; Provisional; Region: PRK10459 1166130003432 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1166130003433 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 1166130003434 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 1166130003435 phosphomannomutase CpsG; Provisional; Region: PRK15414 1166130003436 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1166130003437 active site 1166130003438 substrate binding site [chemical binding]; other site 1166130003439 metal binding site [ion binding]; metal-binding site 1166130003440 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 1166130003441 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1166130003442 Substrate binding site; other site 1166130003443 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1166130003444 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 1166130003445 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1166130003446 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 1166130003447 active site 1166130003448 GDP-Mannose binding site [chemical binding]; other site 1166130003449 dimer interface [polypeptide binding]; other site 1166130003450 modified nudix motif 1166130003451 metal binding site [ion binding]; metal-binding site 1166130003452 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1166130003453 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1166130003454 NADP binding site [chemical binding]; other site 1166130003455 active site 1166130003456 putative substrate binding site [chemical binding]; other site 1166130003457 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1166130003458 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1166130003459 NADP-binding site; other site 1166130003460 homotetramer interface [polypeptide binding]; other site 1166130003461 substrate binding site [chemical binding]; other site 1166130003462 homodimer interface [polypeptide binding]; other site 1166130003463 active site 1166130003464 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 1166130003465 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 1166130003466 putative trimer interface [polypeptide binding]; other site 1166130003467 putative active site [active] 1166130003468 putative substrate binding site [chemical binding]; other site 1166130003469 putative CoA binding site [chemical binding]; other site 1166130003470 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1166130003471 putative glycosyl transferase; Provisional; Region: PRK10063 1166130003472 active site 1166130003473 putative colanic acid biosynthesis protein; Provisional; Region: wcaD; cl08075 1166130003474 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 1166130003475 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1166130003476 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1166130003477 putative acyl transferase; Provisional; Region: PRK10191 1166130003478 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1166130003479 trimer interface [polypeptide binding]; other site 1166130003480 active site 1166130003481 substrate binding site [chemical binding]; other site 1166130003482 CoA binding site [chemical binding]; other site 1166130003483 putative glycosyl transferase; Provisional; Region: PRK10018 1166130003484 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1166130003485 active site 1166130003486 tyrosine kinase; Provisional; Region: PRK11519 1166130003487 Chain length determinant protein; Region: Wzz; pfam02706 1166130003488 Chain length determinant protein; Region: Wzz; cl15801 1166130003489 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1166130003490 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1166130003491 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1166130003492 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1166130003493 active site 1166130003494 polysaccharide export protein Wza; Provisional; Region: PRK15078 1166130003495 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1166130003496 SLBB domain; Region: SLBB; pfam10531 1166130003497 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1166130003498 FOG: CBS domain [General function prediction only]; Region: COG0517 1166130003499 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1166130003500 Transporter associated domain; Region: CorC_HlyC; smart01091 1166130003501 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1166130003502 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166130003503 DNA-binding site [nucleotide binding]; DNA binding site 1166130003504 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1166130003505 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 1166130003506 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1166130003507 dimer interface [polypeptide binding]; other site 1166130003508 ADP-ribose binding site [chemical binding]; other site 1166130003509 active site 1166130003510 nudix motif; other site 1166130003511 metal binding site [ion binding]; metal-binding site 1166130003512 putative assembly protein; Provisional; Region: PRK10833 1166130003513 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1166130003514 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1166130003515 trimer interface [polypeptide binding]; other site 1166130003516 active site 1166130003517 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1166130003518 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1166130003519 ATP-binding site [chemical binding]; other site 1166130003520 Sugar specificity; other site 1166130003521 Pyrimidine base specificity; other site 1166130003522 putative diguanylate cyclase; Provisional; Region: PRK09776 1166130003523 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 1166130003524 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1166130003525 putative active site [active] 1166130003526 heme pocket [chemical binding]; other site 1166130003527 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1166130003528 putative active site [active] 1166130003529 heme pocket [chemical binding]; other site 1166130003530 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1166130003531 putative active site [active] 1166130003532 heme pocket [chemical binding]; other site 1166130003533 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166130003534 metal binding site [ion binding]; metal-binding site 1166130003535 active site 1166130003536 I-site; other site 1166130003537 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1166130003538 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 1166130003539 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1166130003540 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1166130003541 minor groove reading motif; other site 1166130003542 helix-hairpin-helix signature motif; other site 1166130003543 substrate binding pocket [chemical binding]; other site 1166130003544 active site 1166130003545 putative chaperone; Provisional; Region: PRK11678 1166130003546 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 1166130003547 nucleotide binding site [chemical binding]; other site 1166130003548 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1166130003549 SBD interface [polypeptide binding]; other site 1166130003550 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 1166130003551 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1166130003552 HlyD family secretion protein; Region: HlyD_3; pfam13437 1166130003553 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1166130003554 Protein export membrane protein; Region: SecD_SecF; cl14618 1166130003555 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 1166130003556 putative transporter; Provisional; Region: PRK10504 1166130003557 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130003558 putative substrate translocation pore; other site 1166130003559 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130003560 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 1166130003561 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166130003562 dimerization interface [polypeptide binding]; other site 1166130003563 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1166130003564 dimer interface [polypeptide binding]; other site 1166130003565 phosphorylation site [posttranslational modification] 1166130003566 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166130003567 ATP binding site [chemical binding]; other site 1166130003568 Mg2+ binding site [ion binding]; other site 1166130003569 G-X-G motif; other site 1166130003570 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 1166130003571 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130003572 active site 1166130003573 phosphorylation site [posttranslational modification] 1166130003574 intermolecular recognition site; other site 1166130003575 dimerization interface [polypeptide binding]; other site 1166130003576 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1166130003577 DNA binding site [nucleotide binding] 1166130003578 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1166130003579 non-specific DNA binding site [nucleotide binding]; other site 1166130003580 salt bridge; other site 1166130003581 sequence-specific DNA binding site [nucleotide binding]; other site 1166130003582 2TM domain; Region: 2TM; pfam13239 1166130003583 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1166130003584 binding surface 1166130003585 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1166130003586 TPR motif; other site 1166130003587 putative protease; Provisional; Region: PRK15452 1166130003588 Peptidase family U32; Region: Peptidase_U32; pfam01136 1166130003589 lipid kinase; Reviewed; Region: PRK13054 1166130003590 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1166130003591 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1166130003592 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 4. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_4; cd03329 1166130003593 putative active site pocket [active] 1166130003594 metal binding site [ion binding]; metal-binding site 1166130003595 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 1166130003596 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1166130003597 putative active site; other site 1166130003598 catalytic residue [active] 1166130003599 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1166130003600 dimer interface [polypeptide binding]; other site 1166130003601 substrate binding site [chemical binding]; other site 1166130003602 ATP binding site [chemical binding]; other site 1166130003603 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1166130003604 substrate binding site [chemical binding]; other site 1166130003605 multimerization interface [polypeptide binding]; other site 1166130003606 ATP binding site [chemical binding]; other site 1166130003607 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1166130003608 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1166130003609 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166130003610 putative CheW interface [polypeptide binding]; other site 1166130003611 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1166130003612 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1166130003613 lac repressor; Reviewed; Region: lacI; PRK09526 1166130003614 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1166130003615 DNA binding site [nucleotide binding] 1166130003616 domain linker motif; other site 1166130003617 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1166130003618 ligand binding site [chemical binding]; other site 1166130003619 dimerization interface (open form) [polypeptide binding]; other site 1166130003620 dimerization interface (closed form) [polypeptide binding]; other site 1166130003621 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1166130003622 trimer interface; other site 1166130003623 sugar binding site [chemical binding]; other site 1166130003624 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1166130003625 active site turn [active] 1166130003626 phosphorylation site [posttranslational modification] 1166130003627 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1166130003628 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1166130003629 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1166130003630 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1166130003631 Arabinogalactan endo-1,4-beta-galactosidase [Carbohydrate transport and metabolism]; Region: COG3867 1166130003632 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1166130003633 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130003634 dimer interface [polypeptide binding]; other site 1166130003635 conserved gate region; other site 1166130003636 putative PBP binding loops; other site 1166130003637 ABC-ATPase subunit interface; other site 1166130003638 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130003639 dimer interface [polypeptide binding]; other site 1166130003640 conserved gate region; other site 1166130003641 ABC-ATPase subunit interface; other site 1166130003642 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1166130003643 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1166130003644 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1166130003645 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1166130003646 Walker A/P-loop; other site 1166130003647 ATP binding site [chemical binding]; other site 1166130003648 Q-loop/lid; other site 1166130003649 ABC transporter signature motif; other site 1166130003650 Walker B; other site 1166130003651 D-loop; other site 1166130003652 H-loop/switch region; other site 1166130003653 TOBE domain; Region: TOBE; pfam03459 1166130003654 TOBE domain; Region: TOBE_2; pfam08402 1166130003655 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1166130003656 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1166130003657 putative NAD(P) binding site [chemical binding]; other site 1166130003658 dimer interface [polypeptide binding]; other site 1166130003659 Predicted integral membrane protein [Function unknown]; Region: COG5455 1166130003660 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1166130003661 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166130003662 Coenzyme A binding pocket [chemical binding]; other site 1166130003663 antiporter inner membrane protein; Provisional; Region: PRK11670 1166130003664 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1166130003665 Walker A motif; other site 1166130003666 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1166130003667 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1166130003668 active site 1166130003669 HIGH motif; other site 1166130003670 KMSKS motif; other site 1166130003671 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1166130003672 tRNA binding surface [nucleotide binding]; other site 1166130003673 anticodon binding site; other site 1166130003674 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1166130003675 dimer interface [polypeptide binding]; other site 1166130003676 putative tRNA-binding site [nucleotide binding]; other site 1166130003677 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 1166130003678 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 1166130003679 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1166130003680 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1166130003681 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 1166130003682 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130003683 active site 1166130003684 phosphorylation site [posttranslational modification] 1166130003685 intermolecular recognition site; other site 1166130003686 dimerization interface [polypeptide binding]; other site 1166130003687 LytTr DNA-binding domain; Region: LytTR; pfam04397 1166130003688 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1166130003689 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1166130003690 GAF domain; Region: GAF; pfam01590 1166130003691 Histidine kinase; Region: His_kinase; pfam06580 1166130003692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166130003693 ATP binding site [chemical binding]; other site 1166130003694 Mg2+ binding site [ion binding]; other site 1166130003695 G-X-G motif; other site 1166130003696 transcriptional regulator MirA; Provisional; Region: PRK15043 1166130003697 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 1166130003698 DNA binding residues [nucleotide binding] 1166130003699 hypothetical protein; Provisional; Region: PRK13681 1166130003700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130003701 putative PBP binding loops; other site 1166130003702 ABC-ATPase subunit interface; other site 1166130003703 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1166130003704 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1166130003705 Walker A/P-loop; other site 1166130003706 ATP binding site [chemical binding]; other site 1166130003707 Q-loop/lid; other site 1166130003708 ABC transporter signature motif; other site 1166130003709 Walker B; other site 1166130003710 D-loop; other site 1166130003711 H-loop/switch region; other site 1166130003712 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130003713 dimer interface [polypeptide binding]; other site 1166130003714 conserved gate region; other site 1166130003715 ABC-ATPase subunit interface; other site 1166130003716 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1166130003717 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1166130003718 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1166130003719 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1166130003720 D-lactate dehydrogenase; Provisional; Region: PRK11183 1166130003721 FAD binding domain; Region: FAD_binding_4; pfam01565 1166130003722 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 1166130003723 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1166130003724 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166130003725 Coenzyme A binding pocket [chemical binding]; other site 1166130003726 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1166130003727 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 1166130003728 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 1166130003729 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1166130003730 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1166130003731 oxidoreductase; Provisional; Region: PRK12743 1166130003732 classical (c) SDRs; Region: SDR_c; cd05233 1166130003733 NAD(P) binding site [chemical binding]; other site 1166130003734 active site 1166130003735 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1166130003736 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166130003737 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130003738 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 1166130003739 putative substrate binding pocket [chemical binding]; other site 1166130003740 putative dimerization interface [polypeptide binding]; other site 1166130003741 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 1166130003742 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1166130003743 FMN binding site [chemical binding]; other site 1166130003744 active site 1166130003745 catalytic residues [active] 1166130003746 substrate binding site [chemical binding]; other site 1166130003747 hypothetical protein; Provisional; Region: PRK01821 1166130003748 hypothetical protein; Provisional; Region: PRK10711 1166130003749 cytidine deaminase; Provisional; Region: PRK09027 1166130003750 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1166130003751 active site 1166130003752 catalytic motif [active] 1166130003753 Zn binding site [ion binding]; other site 1166130003754 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1166130003755 active site 1166130003756 catalytic motif [active] 1166130003757 Zn binding site [ion binding]; other site 1166130003758 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1166130003759 putative active site [active] 1166130003760 BssS protein family; Region: BssS; cl08210 1166130003761 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1166130003762 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1166130003763 TM-ABC transporter signature motif; other site 1166130003764 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1166130003765 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 1166130003766 Walker A/P-loop; other site 1166130003767 ATP binding site [chemical binding]; other site 1166130003768 Q-loop/lid; other site 1166130003769 ABC transporter signature motif; other site 1166130003770 Walker B; other site 1166130003771 D-loop; other site 1166130003772 H-loop/switch region; other site 1166130003773 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1166130003774 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 1166130003775 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 1166130003776 ligand binding site [chemical binding]; other site 1166130003777 calcium binding site [ion binding]; other site 1166130003778 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 1166130003779 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1166130003780 DNA binding site [nucleotide binding] 1166130003781 domain linker motif; other site 1166130003782 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1166130003783 dimerization interface (closed form) [polypeptide binding]; other site 1166130003784 ligand binding site [chemical binding]; other site 1166130003785 Predicted membrane protein [Function unknown]; Region: COG2311 1166130003786 hypothetical protein; Provisional; Region: PRK10835 1166130003787 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1166130003788 GTP cyclohydrolase I; Provisional; Region: PLN03044 1166130003789 active site 1166130003790 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130003791 putative substrate translocation pore; other site 1166130003792 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1166130003793 S-formylglutathione hydrolase; Region: PLN02442 1166130003794 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 1166130003795 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1166130003796 N-terminal plug; other site 1166130003797 ligand-binding site [chemical binding]; other site 1166130003798 lysine transporter; Provisional; Region: PRK10836 1166130003799 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1166130003800 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1166130003801 Walker A/P-loop; other site 1166130003802 ATP binding site [chemical binding]; other site 1166130003803 Q-loop/lid; other site 1166130003804 ABC transporter signature motif; other site 1166130003805 Walker B; other site 1166130003806 D-loop; other site 1166130003807 H-loop/switch region; other site 1166130003808 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1166130003809 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130003810 dimer interface [polypeptide binding]; other site 1166130003811 conserved gate region; other site 1166130003812 putative PBP binding loops; other site 1166130003813 ABC-ATPase subunit interface; other site 1166130003814 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130003815 dimer interface [polypeptide binding]; other site 1166130003816 conserved gate region; other site 1166130003817 putative PBP binding loops; other site 1166130003818 ABC-ATPase subunit interface; other site 1166130003819 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1166130003820 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166130003821 substrate binding pocket [chemical binding]; other site 1166130003822 membrane-bound complex binding site; other site 1166130003823 hinge residues; other site 1166130003824 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 1166130003825 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130003826 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1166130003827 putative dimerization interface [polypeptide binding]; other site 1166130003828 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 1166130003829 endonuclease IV; Provisional; Region: PRK01060 1166130003830 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1166130003831 AP (apurinic/apyrimidinic) site pocket; other site 1166130003832 DNA interaction; other site 1166130003833 Metal-binding active site; metal-binding site 1166130003834 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 1166130003835 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 1166130003836 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1166130003837 active site 1166130003838 P-loop; other site 1166130003839 phosphorylation site [posttranslational modification] 1166130003840 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 1166130003841 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1166130003842 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1166130003843 putative substrate binding site [chemical binding]; other site 1166130003844 putative ATP binding site [chemical binding]; other site 1166130003845 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 1166130003846 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1166130003847 active site 1166130003848 phosphorylation site [posttranslational modification] 1166130003849 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1166130003850 dimerization domain swap beta strand [polypeptide binding]; other site 1166130003851 regulatory protein interface [polypeptide binding]; other site 1166130003852 active site 1166130003853 regulatory phosphorylation site [posttranslational modification]; other site 1166130003854 sugar efflux transporter B; Provisional; Region: PRK15011 1166130003855 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130003856 putative substrate translocation pore; other site 1166130003857 elongation factor P; Provisional; Region: PRK04542 1166130003858 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1166130003859 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1166130003860 RNA binding site [nucleotide binding]; other site 1166130003861 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1166130003862 RNA binding site [nucleotide binding]; other site 1166130003863 mannonate dehydratase; Provisional; Region: PRK03906 1166130003864 mannonate dehydratase; Region: uxuA; TIGR00695 1166130003865 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1166130003866 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1166130003867 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1166130003868 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1166130003869 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1166130003870 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1166130003871 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1166130003872 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1166130003873 active site 1166130003874 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 1166130003875 NlpC/P60 family; Region: NLPC_P60; pfam00877 1166130003876 phage resistance protein; Provisional; Region: PRK10551 1166130003877 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1166130003878 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1166130003879 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1166130003880 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1166130003881 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1166130003882 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130003883 dimer interface [polypeptide binding]; other site 1166130003884 conserved gate region; other site 1166130003885 putative PBP binding loops; other site 1166130003886 ABC-ATPase subunit interface; other site 1166130003887 microcin C ABC transporter permease; Provisional; Region: PRK15021 1166130003888 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130003889 dimer interface [polypeptide binding]; other site 1166130003890 conserved gate region; other site 1166130003891 ABC-ATPase subunit interface; other site 1166130003892 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 1166130003893 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1166130003894 Walker A/P-loop; other site 1166130003895 ATP binding site [chemical binding]; other site 1166130003896 Q-loop/lid; other site 1166130003897 ABC transporter signature motif; other site 1166130003898 Walker B; other site 1166130003899 D-loop; other site 1166130003900 H-loop/switch region; other site 1166130003901 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1166130003902 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1166130003903 Walker A/P-loop; other site 1166130003904 ATP binding site [chemical binding]; other site 1166130003905 Q-loop/lid; other site 1166130003906 ABC transporter signature motif; other site 1166130003907 Walker B; other site 1166130003908 D-loop; other site 1166130003909 H-loop/switch region; other site 1166130003910 hypothetical protein; Provisional; Region: PRK11835 1166130003911 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130003912 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1166130003913 putative substrate translocation pore; other site 1166130003914 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 1166130003915 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1166130003916 RNA binding surface [nucleotide binding]; other site 1166130003917 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1166130003918 active site 1166130003919 uracil binding [chemical binding]; other site 1166130003920 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1166130003921 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1166130003922 ATP binding site [chemical binding]; other site 1166130003923 putative Mg++ binding site [ion binding]; other site 1166130003924 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1166130003925 nucleotide binding region [chemical binding]; other site 1166130003926 ATP-binding site [chemical binding]; other site 1166130003927 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1166130003928 5S rRNA interface [nucleotide binding]; other site 1166130003929 CTC domain interface [polypeptide binding]; other site 1166130003930 L16 interface [polypeptide binding]; other site 1166130003931 Nucleoid-associated protein [General function prediction only]; Region: COG3081 1166130003932 nucleoid-associated protein NdpA; Validated; Region: PRK00378 1166130003933 hypothetical protein; Provisional; Region: PRK13689 1166130003934 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 1166130003935 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 1166130003936 Sulfatase; Region: Sulfatase; cl17466 1166130003937 hypothetical protein; Provisional; Region: PRK09951 1166130003938 Abi-like protein; Region: Abi_2; pfam07751 1166130003939 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 1166130003940 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1166130003941 active site 1166130003942 DNA binding site [nucleotide binding] 1166130003943 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1166130003944 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1166130003945 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1166130003946 Catalytic site [active] 1166130003947 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1166130003948 Phage-related protein, tail component [Function unknown]; Region: COG4733 1166130003949 Putative phage tail protein; Region: Phage-tail_3; pfam13550 1166130003950 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1166130003951 Interdomain contacts; other site 1166130003952 Cytokine receptor motif; other site 1166130003953 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 1166130003954 Phage-related protein, tail component [Function unknown]; Region: COG4723 1166130003955 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 1166130003956 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 1166130003957 MPN+ (JAMM) motif; other site 1166130003958 Zinc-binding site [ion binding]; other site 1166130003959 NlpC/P60 family; Region: NLPC_P60; pfam00877 1166130003960 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1166130003961 Phage minor tail protein L; Region: Phage_tail_L; cl01908 1166130003962 Phage minor tail protein; Region: Phage_min_tail; pfam05939 1166130003963 Phage-related minor tail protein [Function unknown]; Region: COG5281 1166130003964 tape measure domain; Region: tape_meas_nterm; TIGR02675 1166130003965 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 1166130003966 phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541 1166130003967 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 1166130003968 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 1166130003969 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 1166130003970 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 1166130003971 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 1166130003972 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 1166130003973 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 1166130003974 oligomerization interface [polypeptide binding]; other site 1166130003975 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 1166130003976 Phage-related protein [Function unknown]; Region: COG4695 1166130003977 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 1166130003978 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 1166130003979 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1166130003980 Phage capsid family; Region: Phage_capsid; pfam05065 1166130003981 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1166130003982 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 1166130003983 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1166130003984 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1166130003985 active site 1166130003986 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1166130003987 active site 1166130003988 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 1166130003989 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1166130003990 catalytic residues [active] 1166130003991 Protein of unknown function (DUF754); Region: DUF754; pfam05449 1166130003992 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1166130003993 DNA methylase; Region: N6_N4_Mtase; pfam01555 1166130003994 DNA methylase; Region: N6_N4_Mtase; pfam01555 1166130003995 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1166130003996 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 1166130003997 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 1166130003998 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 1166130003999 Protein of unknown function (DUF968); Region: DUF968; pfam06147 1166130004000 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1166130004001 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1166130004002 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 1166130004003 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1166130004004 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1166130004005 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1166130004006 cofactor binding site; other site 1166130004007 DNA binding site [nucleotide binding] 1166130004008 substrate interaction site [chemical binding]; other site 1166130004009 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1166130004010 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1166130004011 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166130004012 DNA-binding site [nucleotide binding]; DNA binding site 1166130004013 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 1166130004014 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 1166130004015 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1166130004016 non-specific DNA binding site [nucleotide binding]; other site 1166130004017 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1166130004018 salt bridge; other site 1166130004019 sequence-specific DNA binding site [nucleotide binding]; other site 1166130004020 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1166130004021 Catalytic site [active] 1166130004022 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 1166130004023 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1166130004024 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1166130004025 active site 1166130004026 DNA binding site [nucleotide binding] 1166130004027 Int/Topo IB signature motif; other site 1166130004028 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1166130004029 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1166130004030 putative active site [active] 1166130004031 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1166130004032 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1166130004033 Walker A/P-loop; other site 1166130004034 ATP binding site [chemical binding]; other site 1166130004035 Q-loop/lid; other site 1166130004036 ABC transporter signature motif; other site 1166130004037 Walker B; other site 1166130004038 D-loop; other site 1166130004039 H-loop/switch region; other site 1166130004040 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1166130004041 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1166130004042 NAD(P) binding site [chemical binding]; other site 1166130004043 active site 1166130004044 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1166130004045 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1166130004046 active site 2 [active] 1166130004047 active site 1 [active] 1166130004048 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1166130004049 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1166130004050 dimer interface [polypeptide binding]; other site 1166130004051 active site 1166130004052 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1166130004053 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1166130004054 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 1166130004055 Walker A/P-loop; other site 1166130004056 ATP binding site [chemical binding]; other site 1166130004057 Q-loop/lid; other site 1166130004058 ABC transporter signature motif; other site 1166130004059 Walker B; other site 1166130004060 D-loop; other site 1166130004061 H-loop/switch region; other site 1166130004062 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1166130004063 FtsX-like permease family; Region: FtsX; pfam02687 1166130004064 macrolide transporter subunit MacA; Provisional; Region: PRK11578 1166130004065 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1166130004066 HlyD family secretion protein; Region: HlyD_3; pfam13437 1166130004067 malate:quinone oxidoreductase; Validated; Region: PRK05257 1166130004068 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1166130004069 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1166130004070 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1166130004071 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1166130004072 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1166130004073 MgtE intracellular N domain; Region: MgtE_N; smart00924 1166130004074 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1166130004075 Divalent cation transporter; Region: MgtE; cl00786 1166130004076 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 1166130004077 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1166130004078 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1166130004079 Walker A/P-loop; other site 1166130004080 ATP binding site [chemical binding]; other site 1166130004081 Q-loop/lid; other site 1166130004082 ABC transporter signature motif; other site 1166130004083 Walker B; other site 1166130004084 D-loop; other site 1166130004085 H-loop/switch region; other site 1166130004086 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 1166130004087 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 1166130004088 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1166130004089 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130004090 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1166130004091 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1166130004092 DNA binding site [nucleotide binding] 1166130004093 active site 1166130004094 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 1166130004095 ApbE family; Region: ApbE; pfam02424 1166130004096 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1166130004097 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1166130004098 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 1166130004099 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166130004100 ATP binding site [chemical binding]; other site 1166130004101 G-X-G motif; other site 1166130004102 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1166130004103 putative binding surface; other site 1166130004104 active site 1166130004105 transcriptional regulator RcsB; Provisional; Region: PRK10840 1166130004106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130004107 active site 1166130004108 phosphorylation site [posttranslational modification] 1166130004109 intermolecular recognition site; other site 1166130004110 dimerization interface [polypeptide binding]; other site 1166130004111 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1166130004112 DNA binding residues [nucleotide binding] 1166130004113 dimerization interface [polypeptide binding]; other site 1166130004114 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 1166130004115 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1166130004116 dimer interface [polypeptide binding]; other site 1166130004117 phosphorylation site [posttranslational modification] 1166130004118 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166130004119 ATP binding site [chemical binding]; other site 1166130004120 Mg2+ binding site [ion binding]; other site 1166130004121 G-X-G motif; other site 1166130004122 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 1166130004123 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130004124 active site 1166130004125 phosphorylation site [posttranslational modification] 1166130004126 intermolecular recognition site; other site 1166130004127 dimerization interface [polypeptide binding]; other site 1166130004128 DNA gyrase subunit A; Validated; Region: PRK05560 1166130004129 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1166130004130 CAP-like domain; other site 1166130004131 active site 1166130004132 primary dimer interface [polypeptide binding]; other site 1166130004133 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1166130004134 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1166130004135 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1166130004136 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1166130004137 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1166130004138 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1166130004139 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1166130004140 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166130004141 S-adenosylmethionine binding site [chemical binding]; other site 1166130004142 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 1166130004143 ATP cone domain; Region: ATP-cone; pfam03477 1166130004144 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1166130004145 active site 1166130004146 dimer interface [polypeptide binding]; other site 1166130004147 catalytic residues [active] 1166130004148 effector binding site; other site 1166130004149 R2 peptide binding site; other site 1166130004150 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1166130004151 dimer interface [polypeptide binding]; other site 1166130004152 putative radical transfer pathway; other site 1166130004153 diiron center [ion binding]; other site 1166130004154 tyrosyl radical; other site 1166130004155 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1166130004156 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1166130004157 catalytic loop [active] 1166130004158 iron binding site [ion binding]; other site 1166130004159 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 1166130004160 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 1166130004161 active site 1166130004162 catalytic site [active] 1166130004163 metal binding site [ion binding]; metal-binding site 1166130004164 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 1166130004165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130004166 putative substrate translocation pore; other site 1166130004167 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 1166130004168 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1166130004169 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1166130004170 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 1166130004171 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1166130004172 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 1166130004173 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1166130004174 Cysteine-rich domain; Region: CCG; pfam02754 1166130004175 Cysteine-rich domain; Region: CCG; pfam02754 1166130004176 hypothetical protein; Provisional; Region: PRK03673 1166130004177 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1166130004178 putative MPT binding site; other site 1166130004179 Competence-damaged protein; Region: CinA; cl00666 1166130004180 YfaZ precursor; Region: YfaZ; pfam07437 1166130004181 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 1166130004182 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 1166130004183 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 1166130004184 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1166130004185 acyl-activating enzyme (AAE) consensus motif; other site 1166130004186 putative AMP binding site [chemical binding]; other site 1166130004187 putative active site [active] 1166130004188 putative CoA binding site [chemical binding]; other site 1166130004189 O-succinylbenzoate synthase; Provisional; Region: PRK05105 1166130004190 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1166130004191 active site 1166130004192 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1166130004193 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1166130004194 substrate binding site [chemical binding]; other site 1166130004195 oxyanion hole (OAH) forming residues; other site 1166130004196 trimer interface [polypeptide binding]; other site 1166130004197 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 1166130004198 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1166130004199 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1166130004200 dimer interface [polypeptide binding]; other site 1166130004201 tetramer interface [polypeptide binding]; other site 1166130004202 PYR/PP interface [polypeptide binding]; other site 1166130004203 TPP binding site [chemical binding]; other site 1166130004204 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1166130004205 TPP-binding site; other site 1166130004206 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 1166130004207 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1166130004208 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 1166130004209 putative acyltransferase; Provisional; Region: PRK10314 1166130004210 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1166130004211 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1166130004212 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130004213 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1166130004214 active site 1166130004215 phosphorylation site [posttranslational modification] 1166130004216 intermolecular recognition site; other site 1166130004217 dimerization interface [polypeptide binding]; other site 1166130004218 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1166130004219 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1166130004220 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1166130004221 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1166130004222 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1166130004223 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1166130004224 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1166130004225 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1166130004226 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1166130004227 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1166130004228 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1166130004229 4Fe-4S binding domain; Region: Fer4; pfam00037 1166130004230 4Fe-4S binding domain; Region: Fer4; pfam00037 1166130004231 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1166130004232 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 1166130004233 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1166130004234 catalytic loop [active] 1166130004235 iron binding site [ion binding]; other site 1166130004236 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1166130004237 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1166130004238 [4Fe-4S] binding site [ion binding]; other site 1166130004239 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1166130004240 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 1166130004241 SLBB domain; Region: SLBB; pfam10531 1166130004242 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1166130004243 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1166130004244 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1166130004245 putative dimer interface [polypeptide binding]; other site 1166130004246 [2Fe-2S] cluster binding site [ion binding]; other site 1166130004247 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 1166130004248 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1166130004249 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1166130004250 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 1166130004251 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1166130004252 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 1166130004253 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130004254 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 1166130004255 putative dimerization interface [polypeptide binding]; other site 1166130004256 aminotransferase AlaT; Validated; Region: PRK09265 1166130004257 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1166130004258 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130004259 homodimer interface [polypeptide binding]; other site 1166130004260 catalytic residue [active] 1166130004261 5'-nucleotidase; Provisional; Region: PRK03826 1166130004262 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1166130004263 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1166130004264 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1166130004265 TrkA-C domain; Region: TrkA_C; pfam02080 1166130004266 TrkA-C domain; Region: TrkA_C; pfam02080 1166130004267 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1166130004268 putative phosphatase; Provisional; Region: PRK11587 1166130004269 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1166130004270 motif II; other site 1166130004271 hypothetical protein; Validated; Region: PRK05445 1166130004272 hypothetical protein; Provisional; Region: PRK01816 1166130004273 propionate/acetate kinase; Provisional; Region: PRK12379 1166130004274 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1166130004275 phosphate acetyltransferase; Reviewed; Region: PRK05632 1166130004276 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1166130004277 DRTGG domain; Region: DRTGG; pfam07085 1166130004278 phosphate acetyltransferase; Region: pta; TIGR00651 1166130004279 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1166130004280 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1166130004281 PYR/PP interface [polypeptide binding]; other site 1166130004282 dimer interface [polypeptide binding]; other site 1166130004283 TPP binding site [chemical binding]; other site 1166130004284 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1166130004285 transketolase; Reviewed; Region: PRK05899 1166130004286 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1166130004287 TPP-binding site [chemical binding]; other site 1166130004288 dimer interface [polypeptide binding]; other site 1166130004289 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK12996 1166130004290 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1166130004291 active site 1166130004292 P-loop; other site 1166130004293 phosphorylation site [posttranslational modification] 1166130004294 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1166130004295 active site 1166130004296 phosphorylation site [posttranslational modification] 1166130004297 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1166130004298 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1166130004299 DNA binding site [nucleotide binding] 1166130004300 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1166130004301 putative dimerization interface [polypeptide binding]; other site 1166130004302 putative ligand binding site [chemical binding]; other site 1166130004303 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 1166130004304 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 1166130004305 nudix motif; other site 1166130004306 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1166130004307 active site 1166130004308 metal binding site [ion binding]; metal-binding site 1166130004309 homotetramer interface [polypeptide binding]; other site 1166130004310 glutathione S-transferase; Provisional; Region: PRK15113 1166130004311 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1166130004312 C-terminal domain interface [polypeptide binding]; other site 1166130004313 GSH binding site (G-site) [chemical binding]; other site 1166130004314 dimer interface [polypeptide binding]; other site 1166130004315 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 1166130004316 N-terminal domain interface [polypeptide binding]; other site 1166130004317 putative dimer interface [polypeptide binding]; other site 1166130004318 putative substrate binding pocket (H-site) [chemical binding]; other site 1166130004319 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1166130004320 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1166130004321 C-terminal domain interface [polypeptide binding]; other site 1166130004322 GSH binding site (G-site) [chemical binding]; other site 1166130004323 dimer interface [polypeptide binding]; other site 1166130004324 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 1166130004325 N-terminal domain interface [polypeptide binding]; other site 1166130004326 putative dimer interface [polypeptide binding]; other site 1166130004327 active site 1166130004328 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1166130004329 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1166130004330 putative NAD(P) binding site [chemical binding]; other site 1166130004331 putative active site [active] 1166130004332 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1166130004333 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166130004334 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1166130004335 Coenzyme A binding pocket [chemical binding]; other site 1166130004336 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 1166130004337 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1166130004338 Walker A/P-loop; other site 1166130004339 ATP binding site [chemical binding]; other site 1166130004340 Q-loop/lid; other site 1166130004341 ABC transporter signature motif; other site 1166130004342 Walker B; other site 1166130004343 D-loop; other site 1166130004344 H-loop/switch region; other site 1166130004345 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1166130004346 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130004347 dimer interface [polypeptide binding]; other site 1166130004348 conserved gate region; other site 1166130004349 putative PBP binding loops; other site 1166130004350 ABC-ATPase subunit interface; other site 1166130004351 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1166130004352 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130004353 dimer interface [polypeptide binding]; other site 1166130004354 conserved gate region; other site 1166130004355 putative PBP binding loops; other site 1166130004356 ABC-ATPase subunit interface; other site 1166130004357 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 1166130004358 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166130004359 substrate binding pocket [chemical binding]; other site 1166130004360 membrane-bound complex binding site; other site 1166130004361 hinge residues; other site 1166130004362 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 1166130004363 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166130004364 substrate binding pocket [chemical binding]; other site 1166130004365 membrane-bound complex binding site; other site 1166130004366 hinge residues; other site 1166130004367 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 1166130004368 Flavoprotein; Region: Flavoprotein; pfam02441 1166130004369 amidophosphoribosyltransferase; Provisional; Region: PRK09246 1166130004370 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1166130004371 active site 1166130004372 tetramer interface [polypeptide binding]; other site 1166130004373 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1166130004374 active site 1166130004375 colicin V production protein; Provisional; Region: PRK10845 1166130004376 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1166130004377 cell division protein DedD; Provisional; Region: PRK11633 1166130004378 Sporulation related domain; Region: SPOR; pfam05036 1166130004379 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 1166130004380 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1166130004381 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1166130004382 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1166130004383 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1166130004384 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1166130004385 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1166130004386 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1166130004387 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1166130004388 dimerization interface 3.5A [polypeptide binding]; other site 1166130004389 active site 1166130004390 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 1166130004391 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1166130004392 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 1166130004393 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 1166130004394 ligand binding site [chemical binding]; other site 1166130004395 NAD binding site [chemical binding]; other site 1166130004396 catalytic site [active] 1166130004397 homodimer interface [polypeptide binding]; other site 1166130004398 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 1166130004399 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 1166130004400 beta-galactosidase; Region: BGL; TIGR03356 1166130004401 putative transporter; Provisional; Region: PRK12382 1166130004402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130004403 putative substrate translocation pore; other site 1166130004404 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1166130004405 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1166130004406 dimer interface [polypeptide binding]; other site 1166130004407 active site 1166130004408 Uncharacterized conserved protein [Function unknown]; Region: COG4121 1166130004409 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 1166130004410 YfcL protein; Region: YfcL; pfam08891 1166130004411 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 1166130004412 hypothetical protein; Provisional; Region: PRK10621 1166130004413 Predicted permeases [General function prediction only]; Region: COG0730 1166130004414 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 1166130004415 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 1166130004416 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1166130004417 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1166130004418 Tetramer interface [polypeptide binding]; other site 1166130004419 active site 1166130004420 FMN-binding site [chemical binding]; other site 1166130004421 HemK family putative methylases; Region: hemK_fam; TIGR00536 1166130004422 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166130004423 S-adenosylmethionine binding site [chemical binding]; other site 1166130004424 hypothetical protein; Provisional; Region: PRK04946 1166130004425 Smr domain; Region: Smr; pfam01713 1166130004426 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1166130004427 catalytic core [active] 1166130004428 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1166130004429 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1166130004430 substrate binding site [chemical binding]; other site 1166130004431 oxyanion hole (OAH) forming residues; other site 1166130004432 trimer interface [polypeptide binding]; other site 1166130004433 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1166130004434 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1166130004435 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 1166130004436 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1166130004437 dimer interface [polypeptide binding]; other site 1166130004438 active site 1166130004439 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 1166130004440 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 1166130004441 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 1166130004442 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1166130004443 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 1166130004444 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 1166130004445 active site 1166130004446 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 1166130004447 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166130004448 DNA-binding site [nucleotide binding]; DNA binding site 1166130004449 UTRA domain; Region: UTRA; pfam07702 1166130004450 HutD; Region: HutD; pfam05962 1166130004451 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1166130004452 active sites [active] 1166130004453 tetramer interface [polypeptide binding]; other site 1166130004454 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1166130004455 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130004456 ABC-ATPase subunit interface; other site 1166130004457 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1166130004458 dimer interface [polypeptide binding]; other site 1166130004459 conserved gate region; other site 1166130004460 putative PBP binding loops; other site 1166130004461 ABC-ATPase subunit interface; other site 1166130004462 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1166130004463 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1166130004464 Walker A/P-loop; other site 1166130004465 ATP binding site [chemical binding]; other site 1166130004466 Q-loop/lid; other site 1166130004467 ABC transporter signature motif; other site 1166130004468 Walker B; other site 1166130004469 D-loop; other site 1166130004470 H-loop/switch region; other site 1166130004471 urocanate hydratase; Provisional; Region: PRK05414 1166130004472 imidazolonepropionase; Validated; Region: PRK09356 1166130004473 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1166130004474 active site 1166130004475 N-formylglutamate amidohydrolase; Region: FGase; cl01522 1166130004476 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1166130004477 active sites [active] 1166130004478 tetramer interface [polypeptide binding]; other site 1166130004479 Urocanate hydratase [Amino acid transport and metabolism]; Region: HutU; COG2987 1166130004480 urocanate hydratase; Provisional; Region: PRK05414 1166130004481 aminotransferase; Validated; Region: PRK08175 1166130004482 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1166130004483 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130004484 homodimer interface [polypeptide binding]; other site 1166130004485 catalytic residue [active] 1166130004486 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1166130004487 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1166130004488 GAF domain; Region: GAF; pfam01590 1166130004489 Histidine kinase; Region: His_kinase; pfam06580 1166130004490 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166130004491 ATP binding site [chemical binding]; other site 1166130004492 Mg2+ binding site [ion binding]; other site 1166130004493 G-X-G motif; other site 1166130004494 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1166130004495 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130004496 active site 1166130004497 phosphorylation site [posttranslational modification] 1166130004498 intermolecular recognition site; other site 1166130004499 dimerization interface [polypeptide binding]; other site 1166130004500 LytTr DNA-binding domain; Region: LytTR; pfam04397 1166130004501 glucokinase; Provisional; Region: glk; PRK00292 1166130004502 glucokinase, proteobacterial type; Region: glk; TIGR00749 1166130004503 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1166130004504 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1166130004505 Cl- selectivity filter; other site 1166130004506 Cl- binding residues [ion binding]; other site 1166130004507 pore gating glutamate residue; other site 1166130004508 dimer interface [polypeptide binding]; other site 1166130004509 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 1166130004510 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1166130004511 dimer interface [polypeptide binding]; other site 1166130004512 PYR/PP interface [polypeptide binding]; other site 1166130004513 TPP binding site [chemical binding]; other site 1166130004514 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1166130004515 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1166130004516 TPP-binding site [chemical binding]; other site 1166130004517 dimer interface [polypeptide binding]; other site 1166130004518 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1166130004519 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1166130004520 active site 1166130004521 catalytic tetrad [active] 1166130004522 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 1166130004523 manganese transport protein MntH; Reviewed; Region: PRK00701 1166130004524 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1166130004525 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1166130004526 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1166130004527 Nucleoside recognition; Region: Gate; pfam07670 1166130004528 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1166130004529 MASE1; Region: MASE1; cl17823 1166130004530 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1166130004531 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1166130004532 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1166130004533 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 1166130004534 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 1166130004535 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1166130004536 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130004537 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1166130004538 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1166130004539 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1166130004540 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1166130004541 Protein of unknown function (DUF419); Region: DUF419; cl15265 1166130004542 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1166130004543 sequence-specific DNA binding site [nucleotide binding]; other site 1166130004544 salt bridge; other site 1166130004545 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130004546 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1166130004547 putative substrate translocation pore; other site 1166130004548 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1166130004549 EamA-like transporter family; Region: EamA; pfam00892 1166130004550 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1166130004551 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1166130004552 DNA binding site [nucleotide binding] 1166130004553 domain linker motif; other site 1166130004554 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 1166130004555 dimerization interface [polypeptide binding]; other site 1166130004556 ligand binding site [chemical binding]; other site 1166130004557 phenylalanine transporter; Provisional; Region: PRK10249 1166130004558 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1166130004559 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1166130004560 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1166130004561 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1166130004562 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1166130004563 active site 1166130004564 metal binding site [ion binding]; metal-binding site 1166130004565 Cache domain; Region: Cache_1; pfam02743 1166130004566 HAMP domain; Region: HAMP; pfam00672 1166130004567 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1166130004568 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166130004569 dimer interface [polypeptide binding]; other site 1166130004570 putative CheW interface [polypeptide binding]; other site 1166130004571 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 1166130004572 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1166130004573 nudix motif; other site 1166130004574 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1166130004575 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1166130004576 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 1166130004577 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1166130004578 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166130004579 Coenzyme A binding pocket [chemical binding]; other site 1166130004580 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166130004581 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130004582 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1166130004583 dimerization interface [polypeptide binding]; other site 1166130004584 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1166130004585 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1166130004586 N-terminal plug; other site 1166130004587 ligand-binding site [chemical binding]; other site 1166130004588 PQQ-like domain; Region: PQQ_2; pfam13360 1166130004589 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1166130004590 FOG: CBS domain [General function prediction only]; Region: COG0517 1166130004591 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1166130004592 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1166130004593 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 1166130004594 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1166130004595 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166130004596 metal binding site [ion binding]; metal-binding site 1166130004597 active site 1166130004598 I-site; other site 1166130004599 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1166130004600 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1166130004601 Walker A/P-loop; other site 1166130004602 ATP binding site [chemical binding]; other site 1166130004603 Q-loop/lid; other site 1166130004604 ABC transporter signature motif; other site 1166130004605 Walker B; other site 1166130004606 D-loop; other site 1166130004607 H-loop/switch region; other site 1166130004608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130004609 dimer interface [polypeptide binding]; other site 1166130004610 conserved gate region; other site 1166130004611 putative PBP binding loops; other site 1166130004612 ABC-ATPase subunit interface; other site 1166130004613 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130004614 dimer interface [polypeptide binding]; other site 1166130004615 conserved gate region; other site 1166130004616 putative PBP binding loops; other site 1166130004617 ABC-ATPase subunit interface; other site 1166130004618 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1166130004619 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166130004620 substrate binding pocket [chemical binding]; other site 1166130004621 membrane-bound complex binding site; other site 1166130004622 hinge residues; other site 1166130004623 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1166130004624 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166130004625 DNA-binding site [nucleotide binding]; DNA binding site 1166130004626 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1166130004627 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130004628 homodimer interface [polypeptide binding]; other site 1166130004629 catalytic residue [active] 1166130004630 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 1166130004631 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1166130004632 Nitrate and nitrite sensing; Region: NIT; pfam08376 1166130004633 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166130004634 dimerization interface [polypeptide binding]; other site 1166130004635 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1166130004636 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166130004637 dimer interface [polypeptide binding]; other site 1166130004638 putative CheW interface [polypeptide binding]; other site 1166130004639 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 1166130004640 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1166130004641 dimer interface [polypeptide binding]; other site 1166130004642 FMN binding site [chemical binding]; other site 1166130004643 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1166130004644 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1166130004645 active site 1166130004646 HIGH motif; other site 1166130004647 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1166130004648 active site 1166130004649 KMSKS motif; other site 1166130004650 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166130004651 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130004652 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1166130004653 putative dimerization interface [polypeptide binding]; other site 1166130004654 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1166130004655 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1166130004656 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 1166130004657 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1166130004658 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1166130004659 nucleotide binding pocket [chemical binding]; other site 1166130004660 K-X-D-G motif; other site 1166130004661 catalytic site [active] 1166130004662 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1166130004663 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1166130004664 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1166130004665 Dimer interface [polypeptide binding]; other site 1166130004666 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 1166130004667 cell division protein ZipA; Provisional; Region: PRK03427 1166130004668 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 1166130004669 FtsZ protein binding site [polypeptide binding]; other site 1166130004670 putative sulfate transport protein CysZ; Validated; Region: PRK04949 1166130004671 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1166130004672 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1166130004673 dimer interface [polypeptide binding]; other site 1166130004674 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130004675 catalytic residue [active] 1166130004676 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1166130004677 dimerization domain swap beta strand [polypeptide binding]; other site 1166130004678 regulatory protein interface [polypeptide binding]; other site 1166130004679 active site 1166130004680 regulatory phosphorylation site [posttranslational modification]; other site 1166130004681 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 1166130004682 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1166130004683 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1166130004684 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1166130004685 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1166130004686 HPr interaction site; other site 1166130004687 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1166130004688 active site 1166130004689 phosphorylation site [posttranslational modification] 1166130004690 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1166130004691 dimer interface [polypeptide binding]; other site 1166130004692 pyridoxamine kinase; Validated; Region: PRK05756 1166130004693 pyridoxal binding site [chemical binding]; other site 1166130004694 ATP binding site [chemical binding]; other site 1166130004695 cysteine synthase B; Region: cysM; TIGR01138 1166130004696 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1166130004697 dimer interface [polypeptide binding]; other site 1166130004698 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130004699 catalytic residue [active] 1166130004700 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 1166130004701 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1166130004702 Walker A/P-loop; other site 1166130004703 ATP binding site [chemical binding]; other site 1166130004704 Q-loop/lid; other site 1166130004705 ABC transporter signature motif; other site 1166130004706 Walker B; other site 1166130004707 D-loop; other site 1166130004708 H-loop/switch region; other site 1166130004709 TOBE-like domain; Region: TOBE_3; pfam12857 1166130004710 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1166130004711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130004712 dimer interface [polypeptide binding]; other site 1166130004713 conserved gate region; other site 1166130004714 putative PBP binding loops; other site 1166130004715 ABC-ATPase subunit interface; other site 1166130004716 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1166130004717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130004718 dimer interface [polypeptide binding]; other site 1166130004719 conserved gate region; other site 1166130004720 putative PBP binding loops; other site 1166130004721 ABC-ATPase subunit interface; other site 1166130004722 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1166130004723 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1166130004724 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1166130004725 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 1166130004726 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 1166130004727 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 1166130004728 putative acetyltransferase; Provisional; Region: PRK03624 1166130004729 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166130004730 Coenzyme A binding pocket [chemical binding]; other site 1166130004731 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 1166130004732 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1166130004733 active site 1166130004734 metal binding site [ion binding]; metal-binding site 1166130004735 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1166130004736 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1166130004737 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 1166130004738 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1166130004739 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1166130004740 putative NAD(P) binding site [chemical binding]; other site 1166130004741 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1166130004742 transaldolase-like protein; Provisional; Region: PTZ00411 1166130004743 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1166130004744 active site 1166130004745 dimer interface [polypeptide binding]; other site 1166130004746 catalytic residue [active] 1166130004747 transketolase; Reviewed; Region: PRK12753 1166130004748 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1166130004749 TPP-binding site [chemical binding]; other site 1166130004750 dimer interface [polypeptide binding]; other site 1166130004751 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1166130004752 PYR/PP interface [polypeptide binding]; other site 1166130004753 dimer interface [polypeptide binding]; other site 1166130004754 TPP binding site [chemical binding]; other site 1166130004755 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1166130004756 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 1166130004757 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 1166130004758 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1166130004759 dimer interface [polypeptide binding]; other site 1166130004760 ADP-ribose binding site [chemical binding]; other site 1166130004761 active site 1166130004762 nudix motif; other site 1166130004763 metal binding site [ion binding]; metal-binding site 1166130004764 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 1166130004765 4Fe-4S binding domain; Region: Fer4; pfam00037 1166130004766 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1166130004767 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1166130004768 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 1166130004769 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1166130004770 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166130004771 dimerization interface [polypeptide binding]; other site 1166130004772 Histidine kinase; Region: HisKA_3; pfam07730 1166130004773 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166130004774 ATP binding site [chemical binding]; other site 1166130004775 Mg2+ binding site [ion binding]; other site 1166130004776 G-X-G motif; other site 1166130004777 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 1166130004778 Protein export membrane protein; Region: SecD_SecF; cl14618 1166130004779 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166130004780 Coenzyme A binding pocket [chemical binding]; other site 1166130004781 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 1166130004782 ArsC family; Region: ArsC; pfam03960 1166130004783 putative catalytic residues [active] 1166130004784 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1166130004785 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1166130004786 metal binding site [ion binding]; metal-binding site 1166130004787 dimer interface [polypeptide binding]; other site 1166130004788 hypothetical protein; Provisional; Region: PRK13664 1166130004789 putative hydrolase; Provisional; Region: PRK11460 1166130004790 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1166130004791 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 1166130004792 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 1166130004793 Helicase; Region: Helicase_RecD; pfam05127 1166130004794 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166130004795 Coenzyme A binding pocket [chemical binding]; other site 1166130004796 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 1166130004797 Predicted metalloprotease [General function prediction only]; Region: COG2321 1166130004798 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1166130004799 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1166130004800 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1166130004801 ATP binding site [chemical binding]; other site 1166130004802 active site 1166130004803 substrate binding site [chemical binding]; other site 1166130004804 lipoprotein; Provisional; Region: PRK11679 1166130004805 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 1166130004806 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1166130004807 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1166130004808 dimer interface [polypeptide binding]; other site 1166130004809 active site 1166130004810 catalytic residue [active] 1166130004811 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 1166130004812 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 1166130004813 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1166130004814 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1166130004815 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1166130004816 catalytic triad [active] 1166130004817 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 1166130004818 4Fe-4S binding domain; Region: Fer4; pfam00037 1166130004819 hydrogenase 4 subunit B; Validated; Region: PRK06521 1166130004820 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1166130004821 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1166130004822 NADH dehydrogenase; Region: NADHdh; cl00469 1166130004823 hydrogenase 4 subunit D; Validated; Region: PRK06525 1166130004824 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1166130004825 hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492 1166130004826 hydrogenase 4 subunit F; Validated; Region: PRK06458 1166130004827 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1166130004828 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 1166130004829 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1166130004830 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1166130004831 hydrogenase 4 subunit H; Validated; Region: PRK08222 1166130004832 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1166130004833 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 1166130004834 Formate hydrogenlyase maturation protein HycH; Region: HycH; pfam07450 1166130004835 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 1166130004836 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1166130004837 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166130004838 Walker A motif; other site 1166130004839 ATP binding site [chemical binding]; other site 1166130004840 Walker B motif; other site 1166130004841 arginine finger; other site 1166130004842 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1166130004843 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 1166130004844 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1166130004845 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1166130004846 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 1166130004847 Peptidase family M48; Region: Peptidase_M48; cl12018 1166130004848 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1166130004849 TPR motif; other site 1166130004850 binding surface 1166130004851 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1166130004852 ArsC family; Region: ArsC; pfam03960 1166130004853 catalytic residues [active] 1166130004854 DNA replication initiation factor; Provisional; Region: PRK08084 1166130004855 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1166130004856 uracil transporter; Provisional; Region: PRK10720 1166130004857 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1166130004858 active site 1166130004859 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1166130004860 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1166130004861 dimerization interface [polypeptide binding]; other site 1166130004862 putative ATP binding site [chemical binding]; other site 1166130004863 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1166130004864 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1166130004865 active site 1166130004866 substrate binding site [chemical binding]; other site 1166130004867 cosubstrate binding site; other site 1166130004868 catalytic site [active] 1166130004869 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 1166130004870 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1166130004871 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1166130004872 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 1166130004873 domain interface [polypeptide binding]; other site 1166130004874 active site 1166130004875 catalytic site [active] 1166130004876 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 1166130004877 domain interface [polypeptide binding]; other site 1166130004878 active site 1166130004879 catalytic site [active] 1166130004880 exopolyphosphatase; Provisional; Region: PRK10854 1166130004881 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1166130004882 MASE1; Region: MASE1; pfam05231 1166130004883 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1166130004884 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1166130004885 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1166130004886 NACHT domain; Region: NACHT; pfam05729 1166130004887 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1166130004888 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1166130004889 Tar ligand binding domain homologue; Region: TarH; pfam02203 1166130004890 dimer interface [polypeptide binding]; other site 1166130004891 ligand binding site [chemical binding]; other site 1166130004892 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1166130004893 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166130004894 dimerization interface [polypeptide binding]; other site 1166130004895 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166130004896 dimer interface [polypeptide binding]; other site 1166130004897 putative CheW interface [polypeptide binding]; other site 1166130004898 GMP synthase; Reviewed; Region: guaA; PRK00074 1166130004899 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1166130004900 AMP/PPi binding site [chemical binding]; other site 1166130004901 candidate oxyanion hole; other site 1166130004902 catalytic triad [active] 1166130004903 potential glutamine specificity residues [chemical binding]; other site 1166130004904 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1166130004905 ATP Binding subdomain [chemical binding]; other site 1166130004906 Ligand Binding sites [chemical binding]; other site 1166130004907 Dimerization subdomain; other site 1166130004908 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1166130004909 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1166130004910 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1166130004911 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1166130004912 active site 1166130004913 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1166130004914 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1166130004915 generic binding surface II; other site 1166130004916 generic binding surface I; other site 1166130004917 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1166130004918 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1166130004919 active site 1166130004920 Zn binding site [ion binding]; other site 1166130004921 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 1166130004922 TolA C-terminal; Region: TolA; pfam06519 1166130004923 GTP-binding protein Der; Reviewed; Region: PRK00093 1166130004924 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1166130004925 G1 box; other site 1166130004926 GTP/Mg2+ binding site [chemical binding]; other site 1166130004927 Switch I region; other site 1166130004928 G2 box; other site 1166130004929 Switch II region; other site 1166130004930 G3 box; other site 1166130004931 G4 box; other site 1166130004932 G5 box; other site 1166130004933 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1166130004934 G1 box; other site 1166130004935 GTP/Mg2+ binding site [chemical binding]; other site 1166130004936 Switch I region; other site 1166130004937 G2 box; other site 1166130004938 G3 box; other site 1166130004939 Switch II region; other site 1166130004940 G4 box; other site 1166130004941 G5 box; other site 1166130004942 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 1166130004943 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 1166130004944 Trp docking motif [polypeptide binding]; other site 1166130004945 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1166130004946 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 1166130004947 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1166130004948 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1166130004949 dimer interface [polypeptide binding]; other site 1166130004950 motif 1; other site 1166130004951 active site 1166130004952 motif 2; other site 1166130004953 motif 3; other site 1166130004954 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1166130004955 anticodon binding site; other site 1166130004956 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1166130004957 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1166130004958 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1166130004959 cytoskeletal protein RodZ; Provisional; Region: PRK10856 1166130004960 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1166130004961 non-specific DNA binding site [nucleotide binding]; other site 1166130004962 salt bridge; other site 1166130004963 sequence-specific DNA binding site [nucleotide binding]; other site 1166130004964 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1166130004965 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 1166130004966 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1166130004967 FeS/SAM binding site; other site 1166130004968 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1166130004969 active site 1166130004970 multimer interface [polypeptide binding]; other site 1166130004971 penicillin-binding protein 1C; Provisional; Region: PRK11240 1166130004972 Transglycosylase; Region: Transgly; pfam00912 1166130004973 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1166130004974 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 1166130004975 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1166130004976 MG2 domain; Region: A2M_N; pfam01835 1166130004977 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1166130004978 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1166130004979 surface patch; other site 1166130004980 thioester region; other site 1166130004981 specificity defining residues; other site 1166130004982 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1166130004983 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1166130004984 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1166130004985 active site turn [active] 1166130004986 phosphorylation site [posttranslational modification] 1166130004987 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1166130004988 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 1166130004989 NAD binding site [chemical binding]; other site 1166130004990 sugar binding site [chemical binding]; other site 1166130004991 divalent metal binding site [ion binding]; other site 1166130004992 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1166130004993 dimer interface [polypeptide binding]; other site 1166130004994 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 1166130004995 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1166130004996 active site residue [active] 1166130004997 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1166130004998 active site residue [active] 1166130004999 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1166130005000 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1166130005001 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1166130005002 putative active site [active] 1166130005003 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1166130005004 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 1166130005005 aminopeptidase B; Provisional; Region: PRK05015 1166130005006 Peptidase; Region: DUF3663; pfam12404 1166130005007 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1166130005008 interface (dimer of trimers) [polypeptide binding]; other site 1166130005009 Substrate-binding/catalytic site; other site 1166130005010 Zn-binding sites [ion binding]; other site 1166130005011 hypothetical protein; Provisional; Region: PRK10721 1166130005012 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1166130005013 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1166130005014 catalytic loop [active] 1166130005015 iron binding site [ion binding]; other site 1166130005016 chaperone protein HscA; Provisional; Region: hscA; PRK05183 1166130005017 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 1166130005018 nucleotide binding site [chemical binding]; other site 1166130005019 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1166130005020 SBD interface [polypeptide binding]; other site 1166130005021 co-chaperone HscB; Provisional; Region: hscB; PRK05014 1166130005022 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1166130005023 HSP70 interaction site [polypeptide binding]; other site 1166130005024 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 1166130005025 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 1166130005026 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1166130005027 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1166130005028 trimerization site [polypeptide binding]; other site 1166130005029 active site 1166130005030 cysteine desulfurase; Provisional; Region: PRK14012 1166130005031 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1166130005032 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1166130005033 catalytic residue [active] 1166130005034 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 1166130005035 Rrf2 family protein; Region: rrf2_super; TIGR00738 1166130005036 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 1166130005037 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1166130005038 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1166130005039 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1166130005040 active site 1166130005041 dimerization interface [polypeptide binding]; other site 1166130005042 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 1166130005043 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 1166130005044 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 1166130005045 PRD domain; Region: PRD; pfam00874 1166130005046 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1166130005047 MFS_1 like family; Region: MFS_1_like; pfam12832 1166130005048 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1166130005049 putative metal binding site [ion binding]; other site 1166130005050 putative homodimer interface [polypeptide binding]; other site 1166130005051 putative homotetramer interface [polypeptide binding]; other site 1166130005052 putative homodimer-homodimer interface [polypeptide binding]; other site 1166130005053 putative allosteric switch controlling residues; other site 1166130005054 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 1166130005055 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1166130005056 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1166130005057 dimer interface [polypeptide binding]; other site 1166130005058 active site 1166130005059 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1166130005060 folate binding site [chemical binding]; other site 1166130005061 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1166130005062 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1166130005063 heme-binding site [chemical binding]; other site 1166130005064 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1166130005065 FAD binding pocket [chemical binding]; other site 1166130005066 FAD binding motif [chemical binding]; other site 1166130005067 phosphate binding motif [ion binding]; other site 1166130005068 beta-alpha-beta structure motif; other site 1166130005069 NAD binding pocket [chemical binding]; other site 1166130005070 Heme binding pocket [chemical binding]; other site 1166130005071 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 1166130005072 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1166130005073 response regulator GlrR; Provisional; Region: PRK15115 1166130005074 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130005075 active site 1166130005076 phosphorylation site [posttranslational modification] 1166130005077 intermolecular recognition site; other site 1166130005078 dimerization interface [polypeptide binding]; other site 1166130005079 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166130005080 Walker A motif; other site 1166130005081 ATP binding site [chemical binding]; other site 1166130005082 Walker B motif; other site 1166130005083 arginine finger; other site 1166130005084 hypothetical protein; Provisional; Region: PRK10722 1166130005085 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1166130005086 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1166130005087 dimer interface [polypeptide binding]; other site 1166130005088 phosphorylation site [posttranslational modification] 1166130005089 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166130005090 ATP binding site [chemical binding]; other site 1166130005091 Mg2+ binding site [ion binding]; other site 1166130005092 G-X-G motif; other site 1166130005093 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1166130005094 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1166130005095 dimerization interface [polypeptide binding]; other site 1166130005096 ATP binding site [chemical binding]; other site 1166130005097 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1166130005098 dimerization interface [polypeptide binding]; other site 1166130005099 ATP binding site [chemical binding]; other site 1166130005100 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1166130005101 putative active site [active] 1166130005102 catalytic triad [active] 1166130005103 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 1166130005104 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166130005105 substrate binding pocket [chemical binding]; other site 1166130005106 membrane-bound complex binding site; other site 1166130005107 hinge residues; other site 1166130005108 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1166130005109 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1166130005110 catalytic residue [active] 1166130005111 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1166130005112 nucleoside/Zn binding site; other site 1166130005113 dimer interface [polypeptide binding]; other site 1166130005114 catalytic motif [active] 1166130005115 hypothetical protein; Provisional; Region: PRK11590 1166130005116 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1166130005117 H+ Antiporter protein; Region: 2A0121; TIGR00900 1166130005118 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130005119 putative substrate translocation pore; other site 1166130005120 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1166130005121 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 1166130005122 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1166130005123 putative active site [active] 1166130005124 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 1166130005125 active site 1166130005126 catalytic triad [active] 1166130005127 oxyanion hole [active] 1166130005128 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1166130005129 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1166130005130 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1166130005131 active site 1166130005132 hydrophilic channel; other site 1166130005133 dimerization interface [polypeptide binding]; other site 1166130005134 catalytic residues [active] 1166130005135 active site lid [active] 1166130005136 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1166130005137 Recombination protein O N terminal; Region: RecO_N; pfam11967 1166130005138 Recombination protein O C terminal; Region: RecO_C; pfam02565 1166130005139 GTPase Era; Reviewed; Region: era; PRK00089 1166130005140 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1166130005141 G1 box; other site 1166130005142 GTP/Mg2+ binding site [chemical binding]; other site 1166130005143 Switch I region; other site 1166130005144 G2 box; other site 1166130005145 Switch II region; other site 1166130005146 G3 box; other site 1166130005147 G4 box; other site 1166130005148 G5 box; other site 1166130005149 KH domain; Region: KH_2; pfam07650 1166130005150 ribonuclease III; Reviewed; Region: rnc; PRK00102 1166130005151 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1166130005152 dimerization interface [polypeptide binding]; other site 1166130005153 active site 1166130005154 metal binding site [ion binding]; metal-binding site 1166130005155 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1166130005156 dsRNA binding site [nucleotide binding]; other site 1166130005157 signal peptidase I; Provisional; Region: PRK10861 1166130005158 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1166130005159 Catalytic site [active] 1166130005160 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1166130005161 GTP-binding protein LepA; Provisional; Region: PRK05433 1166130005162 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1166130005163 G1 box; other site 1166130005164 putative GEF interaction site [polypeptide binding]; other site 1166130005165 GTP/Mg2+ binding site [chemical binding]; other site 1166130005166 Switch I region; other site 1166130005167 G2 box; other site 1166130005168 G3 box; other site 1166130005169 Switch II region; other site 1166130005170 G4 box; other site 1166130005171 G5 box; other site 1166130005172 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1166130005173 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1166130005174 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1166130005175 SoxR reducing system protein RseC; Provisional; Region: PRK10862 1166130005176 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 1166130005177 anti-sigma E factor; Provisional; Region: rseB; PRK09455 1166130005178 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 1166130005179 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 1166130005180 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 1166130005181 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 1166130005182 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1166130005183 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1166130005184 DNA binding residues [nucleotide binding] 1166130005185 L-aspartate oxidase; Provisional; Region: PRK09077 1166130005186 L-aspartate oxidase; Provisional; Region: PRK06175 1166130005187 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1166130005188 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1166130005189 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166130005190 S-adenosylmethionine binding site [chemical binding]; other site 1166130005191 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1166130005192 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1166130005193 ATP binding site [chemical binding]; other site 1166130005194 Mg++ binding site [ion binding]; other site 1166130005195 motif III; other site 1166130005196 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1166130005197 nucleotide binding region [chemical binding]; other site 1166130005198 ATP-binding site [chemical binding]; other site 1166130005199 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 1166130005200 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1166130005201 ligand binding site [chemical binding]; other site 1166130005202 active site 1166130005203 UGI interface [polypeptide binding]; other site 1166130005204 catalytic site [active] 1166130005205 putative methyltransferase; Provisional; Region: PRK10864 1166130005206 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1166130005207 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1166130005208 thioredoxin 2; Provisional; Region: PRK10996 1166130005209 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 1166130005210 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1166130005211 catalytic residues [active] 1166130005212 Uncharacterized conserved protein [Function unknown]; Region: COG3148 1166130005213 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1166130005214 CoA binding domain; Region: CoA_binding_2; pfam13380 1166130005215 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1166130005216 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1166130005217 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1166130005218 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 1166130005219 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 1166130005220 domain interface [polypeptide binding]; other site 1166130005221 putative active site [active] 1166130005222 catalytic site [active] 1166130005223 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 1166130005224 domain interface [polypeptide binding]; other site 1166130005225 putative active site [active] 1166130005226 catalytic site [active] 1166130005227 lipoprotein; Provisional; Region: PRK10759 1166130005228 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1166130005229 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130005230 putative substrate translocation pore; other site 1166130005231 protein disaggregation chaperone; Provisional; Region: PRK10865 1166130005232 Clp amino terminal domain; Region: Clp_N; pfam02861 1166130005233 Clp amino terminal domain; Region: Clp_N; pfam02861 1166130005234 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166130005235 Walker A motif; other site 1166130005236 ATP binding site [chemical binding]; other site 1166130005237 Walker B motif; other site 1166130005238 arginine finger; other site 1166130005239 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166130005240 Walker A motif; other site 1166130005241 ATP binding site [chemical binding]; other site 1166130005242 Walker B motif; other site 1166130005243 arginine finger; other site 1166130005244 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1166130005245 hypothetical protein; Provisional; Region: PRK10723 1166130005246 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1166130005247 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 1166130005248 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1166130005249 RNA binding surface [nucleotide binding]; other site 1166130005250 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1166130005251 active site 1166130005252 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 1166130005253 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1166130005254 30S subunit binding site; other site 1166130005255 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 1166130005256 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 1166130005257 Prephenate dehydratase; Region: PDT; pfam00800 1166130005258 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1166130005259 putative L-Phe binding site [chemical binding]; other site 1166130005260 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1166130005261 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 1166130005262 Chorismate mutase type II; Region: CM_2; cl00693 1166130005263 prephenate dehydrogenase; Validated; Region: PRK08507 1166130005264 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1166130005265 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1166130005266 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1166130005267 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1166130005268 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 1166130005269 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 1166130005270 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 1166130005271 DksA-like zinc finger domain containing protein; Region: PHA00080 1166130005272 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 1166130005273 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 1166130005274 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 1166130005275 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1166130005276 catalytic residues [active] 1166130005277 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 1166130005278 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 1166130005279 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 1166130005280 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1166130005281 baseplate wedge subunit; Provisional; Region: W; PHA02516 1166130005282 baseplate assembly protein; Provisional; Region: J; PHA02568 1166130005283 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 1166130005284 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 1166130005285 Phage Tail Collar Domain; Region: Collar; pfam07484 1166130005286 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1166130005287 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 1166130005288 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1166130005289 major tail sheath protein; Provisional; Region: FI; PHA02560 1166130005290 major tail tube protein; Provisional; Region: FII; PHA02600 1166130005291 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1166130005292 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 1166130005293 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 1166130005294 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 1166130005295 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 1166130005296 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1166130005297 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1166130005298 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1166130005299 RimM N-terminal domain; Region: RimM; pfam01782 1166130005300 PRC-barrel domain; Region: PRC; pfam05239 1166130005301 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1166130005302 signal recognition particle protein; Provisional; Region: PRK10867 1166130005303 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1166130005304 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1166130005305 P loop; other site 1166130005306 GTP binding site [chemical binding]; other site 1166130005307 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1166130005308 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 1166130005309 hypothetical protein; Provisional; Region: PRK11573 1166130005310 Domain of unknown function DUF21; Region: DUF21; pfam01595 1166130005311 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1166130005312 Transporter associated domain; Region: CorC_HlyC; smart01091 1166130005313 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1166130005314 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1166130005315 dimer interface [polypeptide binding]; other site 1166130005316 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1166130005317 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 1166130005318 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1166130005319 recombination and repair protein; Provisional; Region: PRK10869 1166130005320 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1166130005321 Walker A/P-loop; other site 1166130005322 ATP binding site [chemical binding]; other site 1166130005323 Q-loop/lid; other site 1166130005324 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1166130005325 ABC transporter signature motif; other site 1166130005326 Walker B; other site 1166130005327 D-loop; other site 1166130005328 H-loop/switch region; other site 1166130005329 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 1166130005330 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1166130005331 hypothetical protein; Validated; Region: PRK01777 1166130005332 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1166130005333 putative coenzyme Q binding site [chemical binding]; other site 1166130005334 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1166130005335 SmpB-tmRNA interface; other site 1166130005336 integrase; Provisional; Region: PRK09692 1166130005337 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1166130005338 active site 1166130005339 Int/Topo IB signature motif; other site 1166130005340 AAA domain; Region: AAA_17; pfam13207 1166130005341 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 1166130005342 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 1166130005343 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 1166130005344 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 1166130005345 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1166130005346 active site 1166130005347 metal binding site [ion binding]; metal-binding site 1166130005348 Phage associated DNA primase [General function prediction only]; Region: COG3378 1166130005349 D5 N terminal like; Region: D5_N; smart00885 1166130005350 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 1166130005351 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1166130005352 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1166130005353 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1166130005354 Invasin, domain 3; Region: Invasin_D3; pfam09134 1166130005355 Flagellar transcriptional activator (FlhD); Region: FlhD; cl05012 1166130005356 Flagellar transcriptional activator (FlhC); Region: FlhC; cl05036 1166130005357 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1166130005358 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1166130005359 DNA binding residues [nucleotide binding] 1166130005360 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1166130005361 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1166130005362 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1166130005363 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 1166130005364 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1166130005365 flagellar motor switch protein; Validated; Region: fliN; PRK05698 1166130005366 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1166130005367 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1166130005368 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 1166130005369 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 1166130005370 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 1166130005371 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 1166130005372 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 1166130005373 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1166130005374 Walker A motif/ATP binding site; other site 1166130005375 Walker B motif; other site 1166130005376 flagellar assembly protein H; Validated; Region: fliH; PRK05687 1166130005377 Flagellar assembly protein FliH; Region: FliH; pfam02108 1166130005378 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1166130005379 FliG C-terminal domain; Region: FliG_C; pfam01706 1166130005380 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1166130005381 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 1166130005382 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1166130005383 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 1166130005384 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 1166130005385 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1166130005386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166130005387 S-adenosylmethionine binding site [chemical binding]; other site 1166130005388 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1166130005389 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130005390 active site 1166130005391 phosphorylation site [posttranslational modification] 1166130005392 intermolecular recognition site; other site 1166130005393 dimerization interface [polypeptide binding]; other site 1166130005394 CheB methylesterase; Region: CheB_methylest; pfam01339 1166130005395 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1166130005396 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130005397 active site 1166130005398 phosphorylation site [posttranslational modification] 1166130005399 intermolecular recognition site; other site 1166130005400 dimerization interface [polypeptide binding]; other site 1166130005401 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 1166130005402 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1166130005403 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1166130005404 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1166130005405 FHIPEP family; Region: FHIPEP; pfam00771 1166130005406 Flagellar protein FlhE; Region: FlhE; pfam06366 1166130005407 Flagellar protein FlhE; Region: FlhE; pfam06366 1166130005408 Flagellar protein FlhE; Region: FlhE; pfam06366 1166130005409 flagellar protein FliS; Validated; Region: fliS; PRK05685 1166130005410 flagellar capping protein; Reviewed; Region: fliD; PRK08032 1166130005411 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1166130005412 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1166130005413 flagellin; Validated; Region: PRK06819 1166130005414 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1166130005415 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1166130005416 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 1166130005417 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1166130005418 chemotaxis protein CheA; Provisional; Region: PRK10547 1166130005419 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1166130005420 putative binding surface; other site 1166130005421 active site 1166130005422 CheY binding; Region: CheY-binding; pfam09078 1166130005423 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1166130005424 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166130005425 ATP binding site [chemical binding]; other site 1166130005426 Mg2+ binding site [ion binding]; other site 1166130005427 G-X-G motif; other site 1166130005428 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1166130005429 flagellar motor protein MotB; Validated; Region: motB; PRK09041 1166130005430 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1166130005431 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 1166130005432 ligand binding site [chemical binding]; other site 1166130005433 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1166130005434 flagellar motor protein MotA; Validated; Region: PRK09110 1166130005435 Flagellar transcriptional activator (FlhC); Region: FlhC; cl05036 1166130005436 transcriptional activator FlhD; Provisional; Region: PRK02909 1166130005437 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 1166130005438 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1166130005439 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1166130005440 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1166130005441 DNA binding residues [nucleotide binding] 1166130005442 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1166130005443 HAMP domain; Region: HAMP; pfam00672 1166130005444 dimerization interface [polypeptide binding]; other site 1166130005445 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1166130005446 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166130005447 dimer interface [polypeptide binding]; other site 1166130005448 putative CheW interface [polypeptide binding]; other site 1166130005449 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 1166130005450 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1166130005451 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 1166130005452 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1166130005453 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 1166130005454 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 1166130005455 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1166130005456 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1166130005457 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1166130005458 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 1166130005459 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 1166130005460 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 1166130005461 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1166130005462 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1166130005463 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 1166130005464 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1166130005465 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1166130005466 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1166130005467 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1166130005468 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1166130005469 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1166130005470 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1166130005471 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1166130005472 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1166130005473 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1166130005474 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1166130005475 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1166130005476 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1166130005477 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 1166130005478 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1166130005479 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 1166130005480 FlgN protein; Region: FlgN; cl09176 1166130005481 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1166130005482 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1166130005483 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1166130005484 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1166130005485 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1166130005486 catalytic triad [active] 1166130005487 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1166130005488 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1166130005489 RNA polymerase sigma factor; Provisional; Region: PRK12512 1166130005490 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1166130005491 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1166130005492 DNA binding residues [nucleotide binding] 1166130005493 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1166130005494 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166130005495 Walker A/P-loop; other site 1166130005496 ATP binding site [chemical binding]; other site 1166130005497 Q-loop/lid; other site 1166130005498 ABC transporter signature motif; other site 1166130005499 Walker B; other site 1166130005500 D-loop; other site 1166130005501 H-loop/switch region; other site 1166130005502 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1166130005503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130005504 dimer interface [polypeptide binding]; other site 1166130005505 conserved gate region; other site 1166130005506 ABC-ATPase subunit interface; other site 1166130005507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130005508 dimer interface [polypeptide binding]; other site 1166130005509 conserved gate region; other site 1166130005510 putative PBP binding loops; other site 1166130005511 ABC-ATPase subunit interface; other site 1166130005512 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1166130005513 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1166130005514 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1166130005515 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1166130005516 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1166130005517 Walker A/P-loop; other site 1166130005518 ATP binding site [chemical binding]; other site 1166130005519 Q-loop/lid; other site 1166130005520 ABC transporter signature motif; other site 1166130005521 Walker B; other site 1166130005522 D-loop; other site 1166130005523 H-loop/switch region; other site 1166130005524 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 1166130005525 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1166130005526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130005527 dimer interface [polypeptide binding]; other site 1166130005528 conserved gate region; other site 1166130005529 putative PBP binding loops; other site 1166130005530 ABC-ATPase subunit interface; other site 1166130005531 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1166130005532 acid-resistance protein; Provisional; Region: PRK10208 1166130005533 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 1166130005534 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1166130005535 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130005536 catalytic residue [active] 1166130005537 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1166130005538 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1166130005539 putative substrate binding site [chemical binding]; other site 1166130005540 putative ATP binding site [chemical binding]; other site 1166130005541 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1166130005542 trimer interface; other site 1166130005543 sugar binding site [chemical binding]; other site 1166130005544 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1166130005545 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1166130005546 active site turn [active] 1166130005547 phosphorylation site [posttranslational modification] 1166130005548 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1166130005549 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1166130005550 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1166130005551 substrate binding [chemical binding]; other site 1166130005552 active site 1166130005553 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1166130005554 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 1166130005555 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1166130005556 DNA binding site [nucleotide binding] 1166130005557 domain linker motif; other site 1166130005558 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1166130005559 dimerization interface [polypeptide binding]; other site 1166130005560 ligand binding site [chemical binding]; other site 1166130005561 Secretory lipase; Region: LIP; pfam03583 1166130005562 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1166130005563 dimerization interface [polypeptide binding]; other site 1166130005564 putative DNA binding site [nucleotide binding]; other site 1166130005565 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1166130005566 putative Zn2+ binding site [ion binding]; other site 1166130005567 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1166130005568 active site residue [active] 1166130005569 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 1166130005570 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 1166130005571 DNA cytosine methylase; Provisional; Region: PRK10458 1166130005572 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1166130005573 cofactor binding site; other site 1166130005574 DNA binding site [nucleotide binding] 1166130005575 substrate interaction site [chemical binding]; other site 1166130005576 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1166130005577 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1166130005578 dimer interface [polypeptide binding]; other site 1166130005579 ligand binding site [chemical binding]; other site 1166130005580 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166130005581 dimerization interface [polypeptide binding]; other site 1166130005582 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166130005583 dimer interface [polypeptide binding]; other site 1166130005584 putative CheW interface [polypeptide binding]; other site 1166130005585 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 1166130005586 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 1166130005587 hypothetical protein; Provisional; Region: PRK10556 1166130005588 hypothetical protein; Provisional; Region: PRK10132 1166130005589 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1166130005590 catalytic residues [active] 1166130005591 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1166130005592 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1166130005593 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1166130005594 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1166130005595 active site 1166130005596 dimer interface [polypeptide binding]; other site 1166130005597 catalytic residues [active] 1166130005598 effector binding site; other site 1166130005599 R2 peptide binding site; other site 1166130005600 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1166130005601 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1166130005602 dimer interface [polypeptide binding]; other site 1166130005603 putative radical transfer pathway; other site 1166130005604 diiron center [ion binding]; other site 1166130005605 tyrosyl radical; other site 1166130005606 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 1166130005607 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1166130005608 Walker A/P-loop; other site 1166130005609 ATP binding site [chemical binding]; other site 1166130005610 Q-loop/lid; other site 1166130005611 ABC transporter signature motif; other site 1166130005612 Walker B; other site 1166130005613 D-loop; other site 1166130005614 H-loop/switch region; other site 1166130005615 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1166130005616 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1166130005617 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130005618 dimer interface [polypeptide binding]; other site 1166130005619 conserved gate region; other site 1166130005620 putative PBP binding loops; other site 1166130005621 ABC-ATPase subunit interface; other site 1166130005622 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 1166130005623 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1166130005624 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1166130005625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130005626 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1166130005627 putative L-valine exporter; Provisional; Region: PRK10408 1166130005628 transcriptional repressor MprA; Provisional; Region: PRK10870 1166130005629 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1166130005630 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 1166130005631 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1166130005632 HlyD family secretion protein; Region: HlyD_3; pfam13437 1166130005633 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1166130005634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130005635 putative substrate translocation pore; other site 1166130005636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130005637 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1166130005638 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1166130005639 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 1166130005640 catalytic site [active] 1166130005641 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1166130005642 glutamate--cysteine ligase; Provisional; Region: PRK02107 1166130005643 Predicted membrane protein [Function unknown]; Region: COG1238 1166130005644 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 1166130005645 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1166130005646 motif II; other site 1166130005647 carbon storage regulator; Provisional; Region: PRK01712 1166130005648 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1166130005649 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1166130005650 motif 1; other site 1166130005651 active site 1166130005652 motif 2; other site 1166130005653 motif 3; other site 1166130005654 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1166130005655 DHHA1 domain; Region: DHHA1; pfam02272 1166130005656 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1166130005657 recombinase A; Provisional; Region: recA; PRK09354 1166130005658 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1166130005659 hexamer interface [polypeptide binding]; other site 1166130005660 Walker A motif; other site 1166130005661 ATP binding site [chemical binding]; other site 1166130005662 Walker B motif; other site 1166130005663 hypothetical protein; Validated; Region: PRK03661 1166130005664 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1166130005665 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1166130005666 metal binding site [ion binding]; metal-binding site 1166130005667 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1166130005668 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1166130005669 ABC-ATPase subunit interface; other site 1166130005670 dimer interface [polypeptide binding]; other site 1166130005671 putative PBP binding regions; other site 1166130005672 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1166130005673 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1166130005674 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1166130005675 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1166130005676 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1166130005677 catalytic residue [active] 1166130005678 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 1166130005679 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 1166130005680 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 1166130005681 Nucleoside recognition; Region: Gate; pfam07670 1166130005682 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 1166130005683 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 1166130005684 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 1166130005685 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 1166130005686 putative NAD(P) binding site [chemical binding]; other site 1166130005687 active site 1166130005688 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 1166130005689 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 1166130005690 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1166130005691 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1166130005692 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 1166130005693 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1166130005694 putative active site [active] 1166130005695 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1166130005696 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 1166130005697 GAF domain; Region: GAF; pfam01590 1166130005698 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166130005699 Walker A motif; other site 1166130005700 ATP binding site [chemical binding]; other site 1166130005701 Walker B motif; other site 1166130005702 arginine finger; other site 1166130005703 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 1166130005704 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1166130005705 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1166130005706 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1166130005707 iron binding site [ion binding]; other site 1166130005708 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 1166130005709 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1166130005710 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 1166130005711 Acylphosphatase; Region: Acylphosphatase; pfam00708 1166130005712 HypF finger; Region: zf-HYPF; pfam07503 1166130005713 HypF finger; Region: zf-HYPF; pfam07503 1166130005714 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 1166130005715 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1166130005716 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1166130005717 [4Fe-4S] binding site [ion binding]; other site 1166130005718 molybdopterin cofactor binding site; other site 1166130005719 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 1166130005720 molybdopterin cofactor binding site; other site 1166130005721 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 1166130005722 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1166130005723 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1166130005724 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1166130005725 DNA binding site [nucleotide binding] 1166130005726 domain linker motif; other site 1166130005727 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1166130005728 dimerization interface (closed form) [polypeptide binding]; other site 1166130005729 ligand binding site [chemical binding]; other site 1166130005730 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 1166130005731 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1166130005732 active site turn [active] 1166130005733 phosphorylation site [posttranslational modification] 1166130005734 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1166130005735 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 1166130005736 beta-galactosidase; Region: BGL; TIGR03356 1166130005737 oxidoreductase; Provisional; Region: PRK06128 1166130005738 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1166130005739 NAD binding site [chemical binding]; other site 1166130005740 metal binding site [ion binding]; metal-binding site 1166130005741 active site 1166130005742 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1166130005743 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1166130005744 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 1166130005745 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1166130005746 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1166130005747 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1166130005748 DNA binding site [nucleotide binding] 1166130005749 active site 1166130005750 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1166130005751 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1166130005752 tetramer interface [polypeptide binding]; other site 1166130005753 active site 1166130005754 Mg2+/Mn2+ binding site [ion binding]; other site 1166130005755 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1166130005756 non-specific DNA binding site [nucleotide binding]; other site 1166130005757 salt bridge; other site 1166130005758 sequence-specific DNA binding site [nucleotide binding]; other site 1166130005759 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 1166130005760 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1166130005761 dimerization interface [polypeptide binding]; other site 1166130005762 putative DNA binding site [nucleotide binding]; other site 1166130005763 putative Zn2+ binding site [ion binding]; other site 1166130005764 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1166130005765 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1166130005766 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1166130005767 active site turn [active] 1166130005768 phosphorylation site [posttranslational modification] 1166130005769 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1166130005770 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1166130005771 HPr interaction site; other site 1166130005772 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1166130005773 active site 1166130005774 phosphorylation site [posttranslational modification] 1166130005775 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1166130005776 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1166130005777 DNA binding site [nucleotide binding] 1166130005778 domain linker motif; other site 1166130005779 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1166130005780 dimerization interface (closed form) [polypeptide binding]; other site 1166130005781 ligand binding site [chemical binding]; other site 1166130005782 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1166130005783 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1166130005784 active site 1166130005785 catalytic tetrad [active] 1166130005786 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166130005787 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130005788 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1166130005789 putative effector binding pocket; other site 1166130005790 putative dimerization interface [polypeptide binding]; other site 1166130005791 GAF domain; Region: GAF; pfam01590 1166130005792 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1166130005793 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1166130005794 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166130005795 metal binding site [ion binding]; metal-binding site 1166130005796 active site 1166130005797 I-site; other site 1166130005798 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 1166130005799 nickel binding site [ion binding]; other site 1166130005800 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 1166130005801 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 1166130005802 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 1166130005803 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1166130005804 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 1166130005805 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1166130005806 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1166130005807 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1166130005808 NADH dehydrogenase; Region: NADHdh; cl00469 1166130005809 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 1166130005810 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1166130005811 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 1166130005812 4Fe-4S binding domain; Region: Fer4; pfam00037 1166130005813 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 1166130005814 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 1166130005815 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 1166130005816 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 1166130005817 hydrogenase assembly chaperone; Provisional; Region: PRK10409 1166130005818 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 1166130005819 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 1166130005820 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 1166130005821 dimerization interface [polypeptide binding]; other site 1166130005822 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 1166130005823 ATP binding site [chemical binding]; other site 1166130005824 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 1166130005825 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1166130005826 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1166130005827 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166130005828 Walker A motif; other site 1166130005829 ATP binding site [chemical binding]; other site 1166130005830 Walker B motif; other site 1166130005831 arginine finger; other site 1166130005832 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1166130005833 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 1166130005834 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1166130005835 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1166130005836 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1166130005837 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1166130005838 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 1166130005839 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1166130005840 catalytic residues [active] 1166130005841 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1166130005842 dimer interface [polypeptide binding]; other site 1166130005843 phosphorylation site [posttranslational modification] 1166130005844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166130005845 ATP binding site [chemical binding]; other site 1166130005846 Mg2+ binding site [ion binding]; other site 1166130005847 G-X-G motif; other site 1166130005848 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1166130005849 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130005850 active site 1166130005851 phosphorylation site [posttranslational modification] 1166130005852 intermolecular recognition site; other site 1166130005853 dimerization interface [polypeptide binding]; other site 1166130005854 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1166130005855 DNA binding site [nucleotide binding] 1166130005856 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1166130005857 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1166130005858 [4Fe-4S] binding site [ion binding]; other site 1166130005859 molybdopterin cofactor binding site; other site 1166130005860 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1166130005861 molybdopterin cofactor binding site; other site 1166130005862 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1166130005863 Flavodoxin; Region: Flavodoxin_1; pfam00258 1166130005864 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1166130005865 FAD binding pocket [chemical binding]; other site 1166130005866 FAD binding motif [chemical binding]; other site 1166130005867 catalytic residues [active] 1166130005868 NAD binding pocket [chemical binding]; other site 1166130005869 phosphate binding motif [ion binding]; other site 1166130005870 beta-alpha-beta structure motif; other site 1166130005871 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1166130005872 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1166130005873 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1166130005874 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1166130005875 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1166130005876 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1166130005877 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1166130005878 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1166130005879 Walker A/P-loop; other site 1166130005880 ATP binding site [chemical binding]; other site 1166130005881 Q-loop/lid; other site 1166130005882 ABC transporter signature motif; other site 1166130005883 Walker B; other site 1166130005884 D-loop; other site 1166130005885 H-loop/switch region; other site 1166130005886 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1166130005887 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130005888 dimer interface [polypeptide binding]; other site 1166130005889 conserved gate region; other site 1166130005890 putative PBP binding loops; other site 1166130005891 ABC-ATPase subunit interface; other site 1166130005892 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1166130005893 NMT1-like family; Region: NMT1_2; pfam13379 1166130005894 Nitrate and nitrite sensing; Region: NIT; pfam08376 1166130005895 ANTAR domain; Region: ANTAR; pfam03861 1166130005896 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1166130005897 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1166130005898 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1166130005899 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1166130005900 Putative catalytic domain, repeat 1, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_1; cd09172 1166130005901 PLD-like domain; Region: PLDc_2; pfam13091 1166130005902 putative active site [active] 1166130005903 catalytic site [active] 1166130005904 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 1166130005905 PLD-like domain; Region: PLDc_2; pfam13091 1166130005906 putative active site [active] 1166130005907 catalytic site [active] 1166130005908 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1166130005909 TPR motif; other site 1166130005910 binding surface 1166130005911 TPR repeat; Region: TPR_11; pfam13414 1166130005912 RNA polymerase sigma factor; Provisional; Region: PRK12547 1166130005913 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1166130005914 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1166130005915 DNA binding residues [nucleotide binding] 1166130005916 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1166130005917 YceI-like domain; Region: YceI; smart00867 1166130005918 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1166130005919 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130005920 active site 1166130005921 phosphorylation site [posttranslational modification] 1166130005922 intermolecular recognition site; other site 1166130005923 dimerization interface [polypeptide binding]; other site 1166130005924 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1166130005925 DNA binding site [nucleotide binding] 1166130005926 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1166130005927 HAMP domain; Region: HAMP; pfam00672 1166130005928 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1166130005929 dimer interface [polypeptide binding]; other site 1166130005930 phosphorylation site [posttranslational modification] 1166130005931 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166130005932 ATP binding site [chemical binding]; other site 1166130005933 Mg2+ binding site [ion binding]; other site 1166130005934 G-X-G motif; other site 1166130005935 Predicted membrane protein [Function unknown]; Region: COG2259 1166130005936 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 1166130005937 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1166130005938 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1166130005939 potential catalytic triad [active] 1166130005940 conserved cys residue [active] 1166130005941 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1166130005942 active site 1166130005943 P-loop; other site 1166130005944 phosphorylation site [posttranslational modification] 1166130005945 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 1166130005946 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1166130005947 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1166130005948 methionine cluster; other site 1166130005949 active site 1166130005950 phosphorylation site [posttranslational modification] 1166130005951 metal binding site [ion binding]; metal-binding site 1166130005952 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 1166130005953 Cupin domain; Region: Cupin_2; pfam07883 1166130005954 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130005955 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1166130005956 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1166130005957 NAD binding site [chemical binding]; other site 1166130005958 sugar binding site [chemical binding]; other site 1166130005959 divalent metal binding site [ion binding]; other site 1166130005960 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1166130005961 dimer interface [polypeptide binding]; other site 1166130005962 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 1166130005963 putative active site [active] 1166130005964 YdjC motif; other site 1166130005965 Mg binding site [ion binding]; other site 1166130005966 putative homodimer interface [polypeptide binding]; other site 1166130005967 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 1166130005968 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1166130005969 trimer interface; other site 1166130005970 sugar binding site [chemical binding]; other site 1166130005971 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1166130005972 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1166130005973 NAD(P) binding site [chemical binding]; other site 1166130005974 active site 1166130005975 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 1166130005976 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1166130005977 NAD(P) binding site [chemical binding]; other site 1166130005978 active site 1166130005979 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1166130005980 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130005981 putative substrate translocation pore; other site 1166130005982 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1166130005983 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1166130005984 conserved cys residue [active] 1166130005985 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130005986 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130005987 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1166130005988 Cupin; Region: Cupin_6; pfam12852 1166130005989 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130005990 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1166130005991 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 1166130005992 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 1166130005993 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166130005994 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130005995 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1166130005996 putative effector binding pocket; other site 1166130005997 dimerization interface [polypeptide binding]; other site 1166130005998 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1166130005999 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1166130006000 FMN binding site [chemical binding]; other site 1166130006001 active site 1166130006002 substrate binding site [chemical binding]; other site 1166130006003 catalytic residue [active] 1166130006004 short chain dehydrogenase; Provisional; Region: PRK07041 1166130006005 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1166130006006 NAD(P) binding site [chemical binding]; other site 1166130006007 active site 1166130006008 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 1166130006009 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1166130006010 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130006011 Helix-turn-helix domain; Region: HTH_18; pfam12833 1166130006012 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1166130006013 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1166130006014 NAD(P) binding site [chemical binding]; other site 1166130006015 active site 1166130006016 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1166130006017 MutS domain I; Region: MutS_I; pfam01624 1166130006018 MutS domain II; Region: MutS_II; pfam05188 1166130006019 MutS domain III; Region: MutS_III; pfam05192 1166130006020 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1166130006021 Walker A/P-loop; other site 1166130006022 ATP binding site [chemical binding]; other site 1166130006023 Q-loop/lid; other site 1166130006024 ABC transporter signature motif; other site 1166130006025 Walker B; other site 1166130006026 D-loop; other site 1166130006027 H-loop/switch region; other site 1166130006028 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166130006029 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130006030 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1166130006031 putative effector binding pocket; other site 1166130006032 dimerization interface [polypeptide binding]; other site 1166130006033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130006034 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1166130006035 putative substrate translocation pore; other site 1166130006036 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 1166130006037 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 1166130006038 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1166130006039 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1166130006040 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1166130006041 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1166130006042 DNA binding residues [nucleotide binding] 1166130006043 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 1166130006044 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1166130006045 Peptidase family M23; Region: Peptidase_M23; pfam01551 1166130006046 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1166130006047 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166130006048 S-adenosylmethionine binding site [chemical binding]; other site 1166130006049 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1166130006050 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 1166130006051 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 1166130006052 Permutation of conserved domain; other site 1166130006053 active site 1166130006054 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1166130006055 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1166130006056 homotrimer interaction site [polypeptide binding]; other site 1166130006057 zinc binding site [ion binding]; other site 1166130006058 CDP-binding sites; other site 1166130006059 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1166130006060 substrate binding site; other site 1166130006061 dimer interface; other site 1166130006062 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 1166130006063 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1166130006064 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 1166130006065 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1166130006066 ligand-binding site [chemical binding]; other site 1166130006067 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 1166130006068 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1166130006069 CysD dimerization site [polypeptide binding]; other site 1166130006070 G1 box; other site 1166130006071 putative GEF interaction site [polypeptide binding]; other site 1166130006072 GTP/Mg2+ binding site [chemical binding]; other site 1166130006073 Switch I region; other site 1166130006074 G2 box; other site 1166130006075 G3 box; other site 1166130006076 Switch II region; other site 1166130006077 G4 box; other site 1166130006078 G5 box; other site 1166130006079 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1166130006080 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1166130006081 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1166130006082 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1166130006083 Active Sites [active] 1166130006084 siroheme synthase; Provisional; Region: cysG; PRK10637 1166130006085 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1166130006086 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1166130006087 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1166130006088 active site 1166130006089 SAM binding site [chemical binding]; other site 1166130006090 homodimer interface [polypeptide binding]; other site 1166130006091 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 1166130006092 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1166130006093 metal binding site [ion binding]; metal-binding site 1166130006094 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 1166130006095 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1166130006096 hypothetical protein; Provisional; Region: PRK10873 1166130006097 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1166130006098 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130006099 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1166130006100 dimerization interface [polypeptide binding]; other site 1166130006101 substrate binding pocket [chemical binding]; other site 1166130006102 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1166130006103 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1166130006104 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1166130006105 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1166130006106 catalytic residue [active] 1166130006107 Fe-S metabolism associated domain; Region: SufE; cl00951 1166130006108 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 1166130006109 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1166130006110 putative ATP binding site [chemical binding]; other site 1166130006111 putative substrate interface [chemical binding]; other site 1166130006112 murein transglycosylase A; Provisional; Region: mltA; PRK11162 1166130006113 MltA specific insert domain; Region: MltA; smart00925 1166130006114 3D domain; Region: 3D; pfam06725 1166130006115 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 1166130006116 AMIN domain; Region: AMIN; pfam11741 1166130006117 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1166130006118 active site 1166130006119 metal binding site [ion binding]; metal-binding site 1166130006120 N-acetylglutamate synthase; Validated; Region: PRK05279 1166130006121 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 1166130006122 putative feedback inhibition sensing region; other site 1166130006123 putative nucleotide binding site [chemical binding]; other site 1166130006124 putative substrate binding site [chemical binding]; other site 1166130006125 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166130006126 Coenzyme A binding pocket [chemical binding]; other site 1166130006127 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 1166130006128 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 1166130006129 Helicase; Region: Helicase_RecD; pfam05127 1166130006130 Family description; Region: UvrD_C_2; pfam13538 1166130006131 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 1166130006132 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1166130006133 protease3; Provisional; Region: PRK15101 1166130006134 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1166130006135 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1166130006136 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1166130006137 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 1166130006138 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1166130006139 hypothetical protein; Provisional; Region: PRK10332 1166130006140 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 1166130006141 Protein of unknown function (DUF2509); Region: DUF2509; cl11672 1166130006142 hypothetical protein; Provisional; Region: PRK10557 1166130006143 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1166130006144 hypothetical protein; Provisional; Region: PRK10506 1166130006145 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1166130006146 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1166130006147 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1166130006148 dimerization interface [polypeptide binding]; other site 1166130006149 active site 1166130006150 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1166130006151 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 1166130006152 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1166130006153 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1166130006154 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1166130006155 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1166130006156 RNA pyrophosphohydrolase; Reviewed; Region: PRK00714 1166130006157 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 1166130006158 putative DNA-binding cleft [nucleotide binding]; other site 1166130006159 putative DNA clevage site; other site 1166130006160 molecular lever; other site 1166130006161 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1166130006162 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1166130006163 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1166130006164 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1166130006165 active site 1166130006166 catalytic tetrad [active] 1166130006167 lysophospholipid transporter LplT; Provisional; Region: PRK11195 1166130006168 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130006169 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 1166130006170 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1166130006171 putative acyl-acceptor binding pocket; other site 1166130006172 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 1166130006173 acyl-activating enzyme (AAE) consensus motif; other site 1166130006174 putative AMP binding site [chemical binding]; other site 1166130006175 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 1166130006176 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1166130006177 DNA binding site [nucleotide binding] 1166130006178 domain linker motif; other site 1166130006179 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1166130006180 dimerization interface (closed form) [polypeptide binding]; other site 1166130006181 ligand binding site [chemical binding]; other site 1166130006182 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166130006183 Coenzyme A binding pocket [chemical binding]; other site 1166130006184 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 1166130006185 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166130006186 DNA-binding site [nucleotide binding]; DNA binding site 1166130006187 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1166130006188 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1166130006189 active site 1166130006190 P-loop; other site 1166130006191 phosphorylation site [posttranslational modification] 1166130006192 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1166130006193 beta-galactosidase; Region: BGL; TIGR03356 1166130006194 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1166130006195 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1166130006196 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1166130006197 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1166130006198 DNA binding site [nucleotide binding] 1166130006199 domain linker motif; other site 1166130006200 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1166130006201 dimerization interface (closed form) [polypeptide binding]; other site 1166130006202 ligand binding site [chemical binding]; other site 1166130006203 diaminopimelate decarboxylase; Provisional; Region: PRK11165 1166130006204 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1166130006205 active site 1166130006206 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1166130006207 substrate binding site [chemical binding]; other site 1166130006208 catalytic residues [active] 1166130006209 dimer interface [polypeptide binding]; other site 1166130006210 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1166130006211 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130006212 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1166130006213 dimerization interface [polypeptide binding]; other site 1166130006214 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1166130006215 aspartate racemase; Region: asp_race; TIGR00035 1166130006216 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1166130006217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130006218 dimer interface [polypeptide binding]; other site 1166130006219 conserved gate region; other site 1166130006220 putative PBP binding loops; other site 1166130006221 ABC-ATPase subunit interface; other site 1166130006222 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1166130006223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130006224 dimer interface [polypeptide binding]; other site 1166130006225 conserved gate region; other site 1166130006226 putative PBP binding loops; other site 1166130006227 ABC-ATPase subunit interface; other site 1166130006228 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1166130006229 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1166130006230 Walker A/P-loop; other site 1166130006231 ATP binding site [chemical binding]; other site 1166130006232 Q-loop/lid; other site 1166130006233 ABC transporter signature motif; other site 1166130006234 Walker B; other site 1166130006235 D-loop; other site 1166130006236 H-loop/switch region; other site 1166130006237 TOBE domain; Region: TOBE; pfam03459 1166130006238 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1166130006239 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1166130006240 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1166130006241 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1166130006242 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130006243 putative substrate translocation pore; other site 1166130006244 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130006245 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 1166130006246 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1166130006247 NADP binding site [chemical binding]; other site 1166130006248 homodimer interface [polypeptide binding]; other site 1166130006249 active site 1166130006250 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 1166130006251 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1166130006252 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1166130006253 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 1166130006254 putative acyltransferase; Provisional; Region: PRK05790 1166130006255 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1166130006256 dimer interface [polypeptide binding]; other site 1166130006257 active site 1166130006258 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1166130006259 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1166130006260 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130006261 dimer interface [polypeptide binding]; other site 1166130006262 conserved gate region; other site 1166130006263 putative PBP binding loops; other site 1166130006264 ABC-ATPase subunit interface; other site 1166130006265 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1166130006266 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1166130006267 Walker A/P-loop; other site 1166130006268 ATP binding site [chemical binding]; other site 1166130006269 Q-loop/lid; other site 1166130006270 ABC transporter signature motif; other site 1166130006271 Walker B; other site 1166130006272 D-loop; other site 1166130006273 H-loop/switch region; other site 1166130006274 NIL domain; Region: NIL; pfam09383 1166130006275 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1166130006276 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1166130006277 dimer interface [polypeptide binding]; other site 1166130006278 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130006279 catalytic residue [active] 1166130006280 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1166130006281 FOG: CBS domain [General function prediction only]; Region: COG0517 1166130006282 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 1166130006283 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1166130006284 homodimer interface [polypeptide binding]; other site 1166130006285 substrate-cofactor binding pocket; other site 1166130006286 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130006287 catalytic residue [active] 1166130006288 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1166130006289 PAS domain; Region: PAS_9; pfam13426 1166130006290 putative active site [active] 1166130006291 heme pocket [chemical binding]; other site 1166130006292 PAS domain S-box; Region: sensory_box; TIGR00229 1166130006293 PAS domain; Region: PAS_8; pfam13188 1166130006294 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1166130006295 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166130006296 metal binding site [ion binding]; metal-binding site 1166130006297 active site 1166130006298 I-site; other site 1166130006299 PAS domain; Region: PAS; smart00091 1166130006300 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166130006301 metal binding site [ion binding]; metal-binding site 1166130006302 active site 1166130006303 I-site; other site 1166130006304 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1166130006305 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 1166130006306 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1166130006307 DXD motif; other site 1166130006308 PilZ domain; Region: PilZ; pfam07238 1166130006309 cellulose synthase regulator protein; Provisional; Region: PRK11114 1166130006310 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 1166130006311 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1166130006312 binding surface 1166130006313 TPR motif; other site 1166130006314 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 1166130006315 Cellulose synthase subunit D; Region: Cellsynth_D; pfam03500 1166130006316 PAS domain; Region: PAS_9; pfam13426 1166130006317 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1166130006318 putative active site [active] 1166130006319 heme pocket [chemical binding]; other site 1166130006320 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1166130006321 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166130006322 metal binding site [ion binding]; metal-binding site 1166130006323 active site 1166130006324 I-site; other site 1166130006325 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1166130006326 active site 1166130006327 tetramer interface; other site 1166130006328 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 1166130006329 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1166130006330 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130006331 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1166130006332 dimerization interface [polypeptide binding]; other site 1166130006333 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1166130006334 dimer interface [polypeptide binding]; other site 1166130006335 FMN binding site [chemical binding]; other site 1166130006336 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 1166130006337 CcdB protein; Region: CcdB; pfam01845 1166130006338 Uncharacterized conserved protein [Function unknown]; Region: COG2850 1166130006339 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166130006340 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130006341 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 1166130006342 putative effector binding pocket; other site 1166130006343 putative dimerization interface [polypeptide binding]; other site 1166130006344 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1166130006345 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 1166130006346 NAD(P) binding site [chemical binding]; other site 1166130006347 active site 1166130006348 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1166130006349 CGNR zinc finger; Region: zf-CGNR; pfam11706 1166130006350 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1166130006351 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1166130006352 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166130006353 S-adenosylmethionine binding site [chemical binding]; other site 1166130006354 Flavivirus glycoprotein, central and dimerisation domains; Region: Flavi_glycoprot; pfam00869 1166130006355 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1166130006356 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1166130006357 sequence-specific DNA binding site [nucleotide binding]; other site 1166130006358 salt bridge; other site 1166130006359 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1166130006360 DNA-binding site [nucleotide binding]; DNA binding site 1166130006361 RNA-binding motif; other site 1166130006362 mannonate dehydratase; Provisional; Region: PRK03906 1166130006363 mannonate dehydratase; Region: uxuA; TIGR00695 1166130006364 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1166130006365 gluconate transporter; Region: gntP; TIGR00791 1166130006366 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1166130006367 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166130006368 dimer interface [polypeptide binding]; other site 1166130006369 putative CheW interface [polypeptide binding]; other site 1166130006370 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166130006371 Coenzyme A binding pocket [chemical binding]; other site 1166130006372 Uncharacterized conserved protein [Function unknown]; Region: COG3592 1166130006373 AAA domain; Region: AAA_33; pfam13671 1166130006374 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1166130006375 active site 1166130006376 PAAR motif; Region: PAAR_motif; pfam05488 1166130006377 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1166130006378 Peptidase family M23; Region: Peptidase_M23; pfam01551 1166130006379 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166130006380 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130006381 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1166130006382 dimerization interface [polypeptide binding]; other site 1166130006383 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 1166130006384 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 1166130006385 Flavoprotein; Region: Flavoprotein; pfam02441 1166130006386 Protein of unknown function (DUF554); Region: DUF554; pfam04474 1166130006387 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 1166130006388 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1166130006389 active site 1166130006390 metal binding site [ion binding]; metal-binding site 1166130006391 nudix motif; other site 1166130006392 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 1166130006393 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1166130006394 dimer interface [polypeptide binding]; other site 1166130006395 putative anticodon binding site; other site 1166130006396 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1166130006397 motif 1; other site 1166130006398 active site 1166130006399 motif 2; other site 1166130006400 motif 3; other site 1166130006401 peptide chain release factor 2; Provisional; Region: PRK08787 1166130006402 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1166130006403 RF-1 domain; Region: RF-1; pfam00472 1166130006404 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 1166130006405 DHH family; Region: DHH; pfam01368 1166130006406 DHHA1 domain; Region: DHHA1; pfam02272 1166130006407 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 1166130006408 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1166130006409 dimerization domain [polypeptide binding]; other site 1166130006410 dimer interface [polypeptide binding]; other site 1166130006411 catalytic residues [active] 1166130006412 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1166130006413 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1166130006414 active site 1166130006415 Int/Topo IB signature motif; other site 1166130006416 flavodoxin FldB; Provisional; Region: PRK12359 1166130006417 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 1166130006418 hypothetical protein; Provisional; Region: PRK10878 1166130006419 putative global regulator; Reviewed; Region: PRK09559 1166130006420 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1166130006421 hemolysin; Provisional; Region: PRK15087 1166130006422 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1166130006423 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1166130006424 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1166130006425 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1166130006426 putative active site [active] 1166130006427 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1166130006428 beta-galactosidase; Region: BGL; TIGR03356 1166130006429 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 1166130006430 classical (c) SDRs; Region: SDR_c; cd05233 1166130006431 NAD(P) binding site [chemical binding]; other site 1166130006432 active site 1166130006433 glycine dehydrogenase; Provisional; Region: PRK05367 1166130006434 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1166130006435 tetramer interface [polypeptide binding]; other site 1166130006436 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130006437 catalytic residue [active] 1166130006438 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1166130006439 tetramer interface [polypeptide binding]; other site 1166130006440 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130006441 catalytic residue [active] 1166130006442 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1166130006443 lipoyl attachment site [posttranslational modification]; other site 1166130006444 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1166130006445 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1166130006446 oxidoreductase; Provisional; Region: PRK08013 1166130006447 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1166130006448 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 1166130006449 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 1166130006450 proline aminopeptidase P II; Provisional; Region: PRK10879 1166130006451 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1166130006452 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1166130006453 active site 1166130006454 hypothetical protein; Reviewed; Region: PRK01736 1166130006455 Z-ring-associated protein; Provisional; Region: PRK10972 1166130006456 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 1166130006457 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1166130006458 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1166130006459 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1166130006460 ligand binding site [chemical binding]; other site 1166130006461 NAD binding site [chemical binding]; other site 1166130006462 tetramer interface [polypeptide binding]; other site 1166130006463 catalytic site [active] 1166130006464 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1166130006465 L-serine binding site [chemical binding]; other site 1166130006466 ACT domain interface; other site 1166130006467 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1166130006468 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1166130006469 active site 1166130006470 dimer interface [polypeptide binding]; other site 1166130006471 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1166130006472 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130006473 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 1166130006474 putative dimerization interface [polypeptide binding]; other site 1166130006475 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1166130006476 oxidative stress defense protein; Provisional; Region: PRK11087 1166130006477 arginine exporter protein; Provisional; Region: PRK09304 1166130006478 mechanosensitive channel MscS; Provisional; Region: PRK10334 1166130006479 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1166130006480 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1166130006481 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 1166130006482 active site 1166130006483 intersubunit interface [polypeptide binding]; other site 1166130006484 zinc binding site [ion binding]; other site 1166130006485 Na+ binding site [ion binding]; other site 1166130006486 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1166130006487 Phosphoglycerate kinase; Region: PGK; pfam00162 1166130006488 substrate binding site [chemical binding]; other site 1166130006489 hinge regions; other site 1166130006490 ADP binding site [chemical binding]; other site 1166130006491 catalytic site [active] 1166130006492 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 1166130006493 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1166130006494 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1166130006495 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1166130006496 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1166130006497 transketolase; Reviewed; Region: PRK12753 1166130006498 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1166130006499 TPP-binding site [chemical binding]; other site 1166130006500 dimer interface [polypeptide binding]; other site 1166130006501 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1166130006502 PYR/PP interface [polypeptide binding]; other site 1166130006503 dimer interface [polypeptide binding]; other site 1166130006504 TPP binding site [chemical binding]; other site 1166130006505 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1166130006506 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1166130006507 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 1166130006508 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1166130006509 dimer interface [polypeptide binding]; other site 1166130006510 active site 1166130006511 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1166130006512 catalytic residues [active] 1166130006513 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1166130006514 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1166130006515 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1166130006516 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1166130006517 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1166130006518 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1166130006519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130006520 putative substrate translocation pore; other site 1166130006521 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 1166130006522 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130006523 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1166130006524 hypothetical protein; Provisional; Region: PRK04860 1166130006525 DNA-specific endonuclease I; Provisional; Region: PRK15137 1166130006526 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 1166130006527 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1166130006528 RNA methyltransferase, RsmE family; Region: TIGR00046 1166130006529 glutathione synthetase; Provisional; Region: PRK05246 1166130006530 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1166130006531 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1166130006532 hypothetical protein; Validated; Region: PRK00228 1166130006533 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1166130006534 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1166130006535 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1166130006536 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 1166130006537 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1166130006538 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1166130006539 Walker A motif; other site 1166130006540 ATP binding site [chemical binding]; other site 1166130006541 Walker B motif; other site 1166130006542 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 1166130006543 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1166130006544 catalytic residue [active] 1166130006545 YGGT family; Region: YGGT; pfam02325 1166130006546 Predicted integral membrane protein [Function unknown]; Region: COG0762 1166130006547 hypothetical protein; Validated; Region: PRK05090 1166130006548 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1166130006549 active site 1166130006550 dimerization interface [polypeptide binding]; other site 1166130006551 HemN family oxidoreductase; Provisional; Region: PRK05660 1166130006552 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1166130006553 FeS/SAM binding site; other site 1166130006554 HemN C-terminal domain; Region: HemN_C; pfam06969 1166130006555 hypothetical protein; Provisional; Region: PRK10626 1166130006556 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 1166130006557 hypothetical protein; Provisional; Region: PRK11702 1166130006558 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1166130006559 adenine DNA glycosylase; Provisional; Region: PRK10880 1166130006560 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1166130006561 minor groove reading motif; other site 1166130006562 helix-hairpin-helix signature motif; other site 1166130006563 substrate binding pocket [chemical binding]; other site 1166130006564 active site 1166130006565 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1166130006566 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1166130006567 DNA binding and oxoG recognition site [nucleotide binding] 1166130006568 oxidative damage protection protein; Provisional; Region: PRK05408 1166130006569 murein transglycosylase C; Provisional; Region: mltC; PRK11671 1166130006570 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 1166130006571 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1166130006572 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1166130006573 catalytic residue [active] 1166130006574 nucleoside transporter; Region: 2A0110; TIGR00889 1166130006575 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 1166130006576 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802 1166130006577 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 1166130006578 Coenzyme A transferase; Region: CoA_trans; cl17247 1166130006579 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1166130006580 citrate lyase subunit gamma; Provisional; Region: PRK13253 1166130006581 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 1166130006582 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 1166130006583 putative active site [active] 1166130006584 (T/H)XGH motif; other site 1166130006585 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1166130006586 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1166130006587 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 1166130006588 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1166130006589 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1166130006590 putative active site [active] 1166130006591 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166130006592 ATP binding site [chemical binding]; other site 1166130006593 Mg2+ binding site [ion binding]; other site 1166130006594 G-X-G motif; other site 1166130006595 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1166130006596 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130006597 active site 1166130006598 phosphorylation site [posttranslational modification] 1166130006599 intermolecular recognition site; other site 1166130006600 dimerization interface [polypeptide binding]; other site 1166130006601 Transcriptional regulator; Region: CitT; pfam12431 1166130006602 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1166130006603 ornithine decarboxylase; Provisional; Region: PRK13578 1166130006604 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1166130006605 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1166130006606 homodimer interface [polypeptide binding]; other site 1166130006607 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130006608 catalytic residue [active] 1166130006609 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1166130006610 Protein of unknown function (DUF554); Region: DUF554; pfam04474 1166130006611 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 1166130006612 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1166130006613 ImpA domain protein; Region: DUF3702; pfam12486 1166130006614 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1166130006615 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 1166130006616 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 1166130006617 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 1166130006618 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 1166130006619 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 1166130006620 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 1166130006621 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1166130006622 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1166130006623 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 1166130006624 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 1166130006625 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 1166130006626 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 1166130006627 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1166130006628 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 1166130006629 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1166130006630 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 1166130006631 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 1166130006632 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1166130006633 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1166130006634 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1166130006635 Peptidase family M23; Region: Peptidase_M23; pfam01551 1166130006636 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1166130006637 catalytic residue [active] 1166130006638 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 1166130006639 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1166130006640 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1166130006641 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 1166130006642 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 1166130006643 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1166130006644 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1166130006645 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166130006646 Walker A motif; other site 1166130006647 ATP binding site [chemical binding]; other site 1166130006648 Walker B motif; other site 1166130006649 arginine finger; other site 1166130006650 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166130006651 Walker A motif; other site 1166130006652 ATP binding site [chemical binding]; other site 1166130006653 Walker B motif; other site 1166130006654 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1166130006655 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1166130006656 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1166130006657 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1166130006658 ligand binding site [chemical binding]; other site 1166130006659 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 1166130006660 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 1166130006661 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1166130006662 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 1166130006663 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1166130006664 Protein of unknown function (DUF770); Region: DUF770; pfam05591 1166130006665 Helix-turn-helix domain; Region: HTH_39; pfam14090 1166130006666 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1166130006667 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1166130006668 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166130006669 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1166130006670 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1166130006671 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166130006672 S-adenosylmethionine binding site [chemical binding]; other site 1166130006673 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166130006674 S-adenosylmethionine binding site [chemical binding]; other site 1166130006675 acetoin reductase; Validated; Region: PRK08643 1166130006676 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 1166130006677 NAD binding site [chemical binding]; other site 1166130006678 homotetramer interface [polypeptide binding]; other site 1166130006679 homodimer interface [polypeptide binding]; other site 1166130006680 active site 1166130006681 substrate binding site [chemical binding]; other site 1166130006682 acetolactate synthase; Reviewed; Region: PRK08617 1166130006683 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1166130006684 PYR/PP interface [polypeptide binding]; other site 1166130006685 dimer interface [polypeptide binding]; other site 1166130006686 TPP binding site [chemical binding]; other site 1166130006687 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1166130006688 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1166130006689 TPP-binding site [chemical binding]; other site 1166130006690 dimer interface [polypeptide binding]; other site 1166130006691 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 1166130006692 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166130006693 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130006694 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 1166130006695 putative dimerization interface [polypeptide binding]; other site 1166130006696 putative substrate binding pocket [chemical binding]; other site 1166130006697 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 1166130006698 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 1166130006699 Domain of unknown function (DUF1971); Region: DUF1971; cl17717 1166130006700 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1166130006701 putative pectinesterase; Region: PLN02432; cl01911 1166130006702 Pectinesterase; Region: Pectinesterase; pfam01095 1166130006703 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 1166130006704 active site 1166130006705 catalytic triad [active] 1166130006706 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1166130006707 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1166130006708 Walker A/P-loop; other site 1166130006709 ATP binding site [chemical binding]; other site 1166130006710 Q-loop/lid; other site 1166130006711 ABC transporter signature motif; other site 1166130006712 Walker B; other site 1166130006713 D-loop; other site 1166130006714 H-loop/switch region; other site 1166130006715 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1166130006716 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130006717 dimer interface [polypeptide binding]; other site 1166130006718 conserved gate region; other site 1166130006719 ABC-ATPase subunit interface; other site 1166130006720 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130006721 dimer interface [polypeptide binding]; other site 1166130006722 conserved gate region; other site 1166130006723 putative PBP binding loops; other site 1166130006724 ABC-ATPase subunit interface; other site 1166130006725 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1166130006726 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1166130006727 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1166130006728 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1166130006729 N-terminal plug; other site 1166130006730 ligand-binding site [chemical binding]; other site 1166130006731 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1166130006732 catalytic residues [active] 1166130006733 putative S-transferase; Provisional; Region: PRK11752 1166130006734 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1166130006735 C-terminal domain interface [polypeptide binding]; other site 1166130006736 GSH binding site (G-site) [chemical binding]; other site 1166130006737 dimer interface [polypeptide binding]; other site 1166130006738 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 1166130006739 dimer interface [polypeptide binding]; other site 1166130006740 N-terminal domain interface [polypeptide binding]; other site 1166130006741 active site 1166130006742 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1166130006743 PAS fold; Region: PAS_3; pfam08447 1166130006744 putative active site [active] 1166130006745 heme pocket [chemical binding]; other site 1166130006746 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1166130006747 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166130006748 metal binding site [ion binding]; metal-binding site 1166130006749 active site 1166130006750 I-site; other site 1166130006751 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 1166130006752 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1166130006753 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1166130006754 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 1166130006755 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 1166130006756 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 1166130006757 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 1166130006758 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 1166130006759 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 1166130006760 putative substrate-binding site; other site 1166130006761 nickel binding site [ion binding]; other site 1166130006762 hydrogenase 2 large subunit; Provisional; Region: PRK10467 1166130006763 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1166130006764 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 1166130006765 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 1166130006766 4Fe-4S binding domain; Region: Fer4; cl02805 1166130006767 hydrogenase 2 small subunit; Provisional; Region: PRK10468 1166130006768 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1166130006769 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1166130006770 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 1166130006771 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 1166130006772 HAMP domain; Region: HAMP; pfam00672 1166130006773 dimerization interface [polypeptide binding]; other site 1166130006774 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166130006775 dimer interface [polypeptide binding]; other site 1166130006776 putative CheW interface [polypeptide binding]; other site 1166130006777 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1166130006778 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1166130006779 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1166130006780 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1166130006781 active site 1166130006782 catalytic tetrad [active] 1166130006783 hypothetical protein; Provisional; Region: PRK05208 1166130006784 oxidoreductase; Provisional; Region: PRK07985 1166130006785 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1166130006786 NAD(P) binding site [chemical binding]; other site 1166130006787 active site 1166130006788 biopolymer transport protein ExbD; Provisional; Region: PRK11267 1166130006789 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1166130006790 biopolymer transport protein ExbB; Provisional; Region: PRK10414 1166130006791 cystathionine beta-lyase; Provisional; Region: PRK08114 1166130006792 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1166130006793 homodimer interface [polypeptide binding]; other site 1166130006794 substrate-cofactor binding pocket; other site 1166130006795 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130006796 catalytic residue [active] 1166130006797 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1166130006798 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1166130006799 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1166130006800 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1166130006801 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130006802 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130006803 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1166130006804 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1166130006805 dimer interface [polypeptide binding]; other site 1166130006806 active site 1166130006807 metal binding site [ion binding]; metal-binding site 1166130006808 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1166130006809 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1166130006810 active site 1166130006811 catalytic tetrad [active] 1166130006812 hypothetical protein; Provisional; Region: PRK01254 1166130006813 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 1166130006814 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 1166130006815 FtsI repressor; Provisional; Region: PRK10883 1166130006816 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1166130006817 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1166130006818 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 1166130006819 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1166130006820 putative acyl-acceptor binding pocket; other site 1166130006821 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1166130006822 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1166130006823 CAP-like domain; other site 1166130006824 active site 1166130006825 primary dimer interface [polypeptide binding]; other site 1166130006826 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 1166130006827 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 1166130006828 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130006829 active site 1166130006830 phosphorylation site [posttranslational modification] 1166130006831 intermolecular recognition site; other site 1166130006832 dimerization interface [polypeptide binding]; other site 1166130006833 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1166130006834 DNA binding site [nucleotide binding] 1166130006835 sensor protein QseC; Provisional; Region: PRK10337 1166130006836 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1166130006837 dimer interface [polypeptide binding]; other site 1166130006838 phosphorylation site [posttranslational modification] 1166130006839 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166130006840 ATP binding site [chemical binding]; other site 1166130006841 G-X-G motif; other site 1166130006842 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1166130006843 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1166130006844 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 1166130006845 galactoside permease; Reviewed; Region: lacY; PRK09528 1166130006846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130006847 putative substrate translocation pore; other site 1166130006848 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 1166130006849 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1166130006850 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130006851 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1166130006852 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130006853 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 1166130006854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166130006855 ATP binding site [chemical binding]; other site 1166130006856 Mg2+ binding site [ion binding]; other site 1166130006857 G-X-G motif; other site 1166130006858 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1166130006859 anchoring element; other site 1166130006860 dimer interface [polypeptide binding]; other site 1166130006861 ATP binding site [chemical binding]; other site 1166130006862 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1166130006863 active site 1166130006864 metal binding site [ion binding]; metal-binding site 1166130006865 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1166130006866 esterase YqiA; Provisional; Region: PRK11071 1166130006867 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1166130006868 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1166130006869 hexamer interface [polypeptide binding]; other site 1166130006870 active site 1166130006871 metal binding site [ion binding]; metal-binding site 1166130006872 putative dehydrogenase; Provisional; Region: PRK11039 1166130006873 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 1166130006874 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1166130006875 dimer interface [polypeptide binding]; other site 1166130006876 ADP-ribose binding site [chemical binding]; other site 1166130006877 active site 1166130006878 nudix motif; other site 1166130006879 metal binding site [ion binding]; metal-binding site 1166130006880 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 1166130006881 hypothetical protein; Provisional; Region: PRK11653 1166130006882 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1166130006883 DctM-like transporters; Region: DctM; pfam06808 1166130006884 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1166130006885 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1166130006886 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1166130006887 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1166130006888 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1166130006889 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1166130006890 putative active site [active] 1166130006891 metal binding site [ion binding]; metal-binding site 1166130006892 zinc transporter ZupT; Provisional; Region: PRK04201 1166130006893 ZIP Zinc transporter; Region: Zip; pfam02535 1166130006894 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 1166130006895 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 1166130006896 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1166130006897 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 1166130006898 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 1166130006899 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1166130006900 putative ribose interaction site [chemical binding]; other site 1166130006901 putative ADP binding site [chemical binding]; other site 1166130006902 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1166130006903 active site 1166130006904 nucleotide binding site [chemical binding]; other site 1166130006905 HIGH motif; other site 1166130006906 KMSKS motif; other site 1166130006907 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 1166130006908 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1166130006909 metal binding triad; other site 1166130006910 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1166130006911 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1166130006912 metal binding triad; other site 1166130006913 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1166130006914 Uncharacterized conserved protein [Function unknown]; Region: COG3025 1166130006915 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 1166130006916 putative active site [active] 1166130006917 putative metal binding residues [ion binding]; other site 1166130006918 signature motif; other site 1166130006919 putative triphosphate binding site [ion binding]; other site 1166130006920 CHAD domain; Region: CHAD; pfam05235 1166130006921 SH3 domain-containing protein; Provisional; Region: PRK10884 1166130006922 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1166130006923 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1166130006924 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1166130006925 active site 1166130006926 NTP binding site [chemical binding]; other site 1166130006927 metal binding triad [ion binding]; metal-binding site 1166130006928 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1166130006929 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1166130006930 Zn2+ binding site [ion binding]; other site 1166130006931 Mg2+ binding site [ion binding]; other site 1166130006932 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1166130006933 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1166130006934 homooctamer interface [polypeptide binding]; other site 1166130006935 active site 1166130006936 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1166130006937 UGMP family protein; Validated; Region: PRK09604 1166130006938 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1166130006939 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1166130006940 DNA primase; Validated; Region: dnaG; PRK05667 1166130006941 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1166130006942 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1166130006943 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1166130006944 active site 1166130006945 metal binding site [ion binding]; metal-binding site 1166130006946 interdomain interaction site; other site 1166130006947 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1166130006948 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 1166130006949 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1166130006950 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1166130006951 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1166130006952 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1166130006953 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1166130006954 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1166130006955 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1166130006956 DNA binding residues [nucleotide binding] 1166130006957 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1166130006958 active site 1166130006959 SUMO-1 interface [polypeptide binding]; other site 1166130006960 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 1166130006961 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 1166130006962 tail protein; Provisional; Region: D; PHA02561 1166130006963 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 1166130006964 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1166130006965 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 1166130006966 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1166130006967 major tail tube protein; Provisional; Region: FII; PHA02600 1166130006968 major tail sheath protein; Provisional; Region: FI; PHA02560 1166130006969 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1166130006970 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 1166130006971 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 1166130006972 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 1166130006973 baseplate assembly protein; Provisional; Region: J; PHA02568 1166130006974 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1166130006975 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1166130006976 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 1166130006977 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1166130006978 Patatin-like phospholipase; Region: Patatin; pfam01734 1166130006979 active site 1166130006980 nucleophile elbow; other site 1166130006981 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1166130006982 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 1166130006983 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 1166130006984 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 1166130006985 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1166130006986 catalytic residues [active] 1166130006987 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 1166130006988 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 1166130006989 terminase endonuclease subunit; Provisional; Region: M; PHA02537 1166130006990 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 1166130006991 capsid protein; Provisional; Region: N; PHA02538 1166130006992 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; pfam05929 1166130006993 terminase ATPase subunit; Provisional; Region: P; PHA02535 1166130006994 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 1166130006995 portal vertex protein; Provisional; Region: Q; PHA02536 1166130006996 Phage portal protein; Region: Phage_portal; pfam04860 1166130006997 endonuclease subunit; Provisional; Region: 46; PHA02562 1166130006998 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 1166130006999 Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961 1166130007000 DksA-like zinc finger domain containing protein; Region: PHA00080 1166130007001 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 1166130007002 Protein of unknown function (DUF2724); Region: DUF2724; pfam10893 1166130007003 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 1166130007004 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 1166130007005 Short C-terminal domain; Region: SHOCT; pfam09851 1166130007006 integrase; Provisional; Region: int; PHA02601 1166130007007 Phage HP1 integrase, C-terminal catalytic domain. Bacteriophage HP1 and related integrases are found in eubacteria, plasmids and temperate bacteriophages of the P2 family. They belong to the DNA breaking-rejoining enzyme superfamily, which includes...; Region: HP1_INT_C; cd00797 1166130007008 dimer interface [polypeptide binding]; other site 1166130007009 active site 1166130007010 catalytic residues [active] 1166130007011 Int/Topo IB signature motif; other site 1166130007012 Uncharacterized conserved protein [Function unknown]; Region: COG3287 1166130007013 FIST N domain; Region: FIST; pfam08495 1166130007014 FIST C domain; Region: FIST_C; pfam10442 1166130007015 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1166130007016 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166130007017 ATP binding site [chemical binding]; other site 1166130007018 Mg2+ binding site [ion binding]; other site 1166130007019 G-X-G motif; other site 1166130007020 Response regulator receiver domain; Region: Response_reg; pfam00072 1166130007021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130007022 active site 1166130007023 phosphorylation site [posttranslational modification] 1166130007024 intermolecular recognition site; other site 1166130007025 dimerization interface [polypeptide binding]; other site 1166130007026 HDOD domain; Region: HDOD; pfam08668 1166130007027 Response regulator receiver domain; Region: Response_reg; pfam00072 1166130007028 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130007029 active site 1166130007030 phosphorylation site [posttranslational modification] 1166130007031 intermolecular recognition site; other site 1166130007032 dimerization interface [polypeptide binding]; other site 1166130007033 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 1166130007034 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1166130007035 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1166130007036 FAD binding pocket [chemical binding]; other site 1166130007037 FAD binding motif [chemical binding]; other site 1166130007038 phosphate binding motif [ion binding]; other site 1166130007039 NAD binding pocket [chemical binding]; other site 1166130007040 Predicted transcriptional regulators [Transcription]; Region: COG1695 1166130007041 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1166130007042 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1166130007043 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1166130007044 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166130007045 dimerization interface [polypeptide binding]; other site 1166130007046 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166130007047 dimer interface [polypeptide binding]; other site 1166130007048 putative CheW interface [polypeptide binding]; other site 1166130007049 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1166130007050 PAS domain; Region: PAS_9; pfam13426 1166130007051 putative active site [active] 1166130007052 heme pocket [chemical binding]; other site 1166130007053 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1166130007054 HAMP domain; Region: HAMP; pfam00672 1166130007055 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1166130007056 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166130007057 dimer interface [polypeptide binding]; other site 1166130007058 putative CheW interface [polypeptide binding]; other site 1166130007059 putrescine aminotransferase; Region: putres_am_tran; TIGR03372 1166130007060 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1166130007061 inhibitor-cofactor binding pocket; inhibition site 1166130007062 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130007063 catalytic residue [active] 1166130007064 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 1166130007065 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1166130007066 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1166130007067 putative active site; other site 1166130007068 catalytic residue [active] 1166130007069 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 1166130007070 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 1166130007071 putative N- and C-terminal domain interface [polypeptide binding]; other site 1166130007072 putative active site [active] 1166130007073 putative MgATP binding site [chemical binding]; other site 1166130007074 catalytic site [active] 1166130007075 metal binding site [ion binding]; metal-binding site 1166130007076 putative carbohydrate binding site [chemical binding]; other site 1166130007077 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1166130007078 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1166130007079 active site 1166130007080 FMN binding site [chemical binding]; other site 1166130007081 2,4-decadienoyl-CoA binding site; other site 1166130007082 catalytic residue [active] 1166130007083 4Fe-4S cluster binding site [ion binding]; other site 1166130007084 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1166130007085 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1166130007086 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 1166130007087 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166130007088 S-adenosylmethionine binding site [chemical binding]; other site 1166130007089 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 1166130007090 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1166130007091 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1166130007092 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1166130007093 serine/threonine transporter SstT; Provisional; Region: PRK13628 1166130007094 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1166130007095 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 1166130007096 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1166130007097 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1166130007098 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1166130007099 Glucuronate isomerase; Region: UxaC; pfam02614 1166130007100 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1166130007101 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130007102 D-galactonate transporter; Region: 2A0114; TIGR00893 1166130007103 putative substrate translocation pore; other site 1166130007104 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 1166130007105 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166130007106 DNA-binding site [nucleotide binding]; DNA binding site 1166130007107 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1166130007108 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1166130007109 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1166130007110 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 1166130007111 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 1166130007112 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 1166130007113 Predicted membrane protein [Function unknown]; Region: COG5393 1166130007114 YqjK-like protein; Region: YqjK; pfam13997 1166130007115 Predicted membrane protein [Function unknown]; Region: COG2259 1166130007116 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1166130007117 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1166130007118 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1166130007119 putative dimer interface [polypeptide binding]; other site 1166130007120 N-terminal domain interface [polypeptide binding]; other site 1166130007121 putative substrate binding pocket (H-site) [chemical binding]; other site 1166130007122 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1166130007123 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130007124 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1166130007125 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1166130007126 dimerization interface [polypeptide binding]; other site 1166130007127 Pirin-related protein [General function prediction only]; Region: COG1741 1166130007128 Pirin; Region: Pirin; pfam02678 1166130007129 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130007130 Helix-turn-helix domain; Region: HTH_18; pfam12833 1166130007131 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130007132 SnoaL-like domain; Region: SnoaL_2; pfam12680 1166130007133 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1166130007134 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1166130007135 catalytic triad [active] 1166130007136 Glycerate kinase family; Region: Gly_kinase; cl00841 1166130007137 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 1166130007138 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1166130007139 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 1166130007140 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130007141 D-galactonate transporter; Region: 2A0114; TIGR00893 1166130007142 putative substrate translocation pore; other site 1166130007143 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1166130007144 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1166130007145 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1166130007146 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 1166130007147 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1166130007148 putative SAM binding site [chemical binding]; other site 1166130007149 putative homodimer interface [polypeptide binding]; other site 1166130007150 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1166130007151 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 1166130007152 putative ligand binding site [chemical binding]; other site 1166130007153 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 1166130007154 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1166130007155 dimer interface [polypeptide binding]; other site 1166130007156 active site 1166130007157 outer membrane lipoprotein; Provisional; Region: PRK11023 1166130007158 BON domain; Region: BON; pfam04972 1166130007159 BON domain; Region: BON; pfam04972 1166130007160 Predicted permease; Region: DUF318; pfam03773 1166130007161 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 1166130007162 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1166130007163 NAD binding site [chemical binding]; other site 1166130007164 active site 1166130007165 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1166130007166 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1166130007167 proposed catalytic triad [active] 1166130007168 conserved cys residue [active] 1166130007169 hypothetical protein; Provisional; Region: PRK03467 1166130007170 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1166130007171 GIY-YIG motif/motif A; other site 1166130007172 putative active site [active] 1166130007173 putative metal binding site [ion binding]; other site 1166130007174 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1166130007175 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166130007176 Coenzyme A binding pocket [chemical binding]; other site 1166130007177 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 1166130007178 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1166130007179 Peptidase family U32; Region: Peptidase_U32; pfam01136 1166130007180 putative protease; Provisional; Region: PRK15447 1166130007181 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1166130007182 hypothetical protein; Provisional; Region: PRK10508 1166130007183 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1166130007184 tryptophan permease; Provisional; Region: PRK10483 1166130007185 aromatic amino acid transport protein; Region: araaP; TIGR00837 1166130007186 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1166130007187 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1166130007188 ATP binding site [chemical binding]; other site 1166130007189 Mg++ binding site [ion binding]; other site 1166130007190 motif III; other site 1166130007191 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1166130007192 nucleotide binding region [chemical binding]; other site 1166130007193 ATP-binding site [chemical binding]; other site 1166130007194 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1166130007195 putative RNA binding site [nucleotide binding]; other site 1166130007196 lipoprotein NlpI; Provisional; Region: PRK11189 1166130007197 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1166130007198 binding surface 1166130007199 TPR motif; other site 1166130007200 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1166130007201 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1166130007202 RNase E interface [polypeptide binding]; other site 1166130007203 trimer interface [polypeptide binding]; other site 1166130007204 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1166130007205 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1166130007206 RNase E interface [polypeptide binding]; other site 1166130007207 trimer interface [polypeptide binding]; other site 1166130007208 active site 1166130007209 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1166130007210 putative nucleic acid binding region [nucleotide binding]; other site 1166130007211 G-X-X-G motif; other site 1166130007212 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1166130007213 RNA binding site [nucleotide binding]; other site 1166130007214 domain interface; other site 1166130007215 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1166130007216 16S/18S rRNA binding site [nucleotide binding]; other site 1166130007217 S13e-L30e interaction site [polypeptide binding]; other site 1166130007218 25S rRNA binding site [nucleotide binding]; other site 1166130007219 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 1166130007220 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1166130007221 RNA binding site [nucleotide binding]; other site 1166130007222 active site 1166130007223 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1166130007224 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1166130007225 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1166130007226 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1166130007227 translation initiation factor IF-2; Validated; Region: infB; PRK05306 1166130007228 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1166130007229 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1166130007230 G1 box; other site 1166130007231 putative GEF interaction site [polypeptide binding]; other site 1166130007232 GTP/Mg2+ binding site [chemical binding]; other site 1166130007233 Switch I region; other site 1166130007234 G2 box; other site 1166130007235 G3 box; other site 1166130007236 Switch II region; other site 1166130007237 G4 box; other site 1166130007238 G5 box; other site 1166130007239 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1166130007240 Translation-initiation factor 2; Region: IF-2; pfam11987 1166130007241 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1166130007242 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1166130007243 NusA N-terminal domain; Region: NusA_N; pfam08529 1166130007244 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1166130007245 RNA binding site [nucleotide binding]; other site 1166130007246 homodimer interface [polypeptide binding]; other site 1166130007247 NusA-like KH domain; Region: KH_5; pfam13184 1166130007248 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1166130007249 G-X-X-G motif; other site 1166130007250 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1166130007251 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1166130007252 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1166130007253 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1166130007254 putative oligomer interface [polypeptide binding]; other site 1166130007255 putative RNA binding site [nucleotide binding]; other site 1166130007256 argininosuccinate synthase; Validated; Region: PRK05370 1166130007257 argininosuccinate synthase; Provisional; Region: PRK13820 1166130007258 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1166130007259 putative fimbrial protein TcfA; Provisional; Region: PRK15308 1166130007260 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1166130007261 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 1166130007262 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1166130007263 active site 1166130007264 substrate binding site [chemical binding]; other site 1166130007265 metal binding site [ion binding]; metal-binding site 1166130007266 dihydropteroate synthase; Region: DHPS; TIGR01496 1166130007267 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1166130007268 substrate binding pocket [chemical binding]; other site 1166130007269 dimer interface [polypeptide binding]; other site 1166130007270 inhibitor binding site; inhibition site 1166130007271 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 1166130007272 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166130007273 Walker A motif; other site 1166130007274 ATP binding site [chemical binding]; other site 1166130007275 Walker B motif; other site 1166130007276 arginine finger; other site 1166130007277 Peptidase family M41; Region: Peptidase_M41; pfam01434 1166130007278 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1166130007279 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166130007280 S-adenosylmethionine binding site [chemical binding]; other site 1166130007281 RNA-binding protein YhbY; Provisional; Region: PRK10343 1166130007282 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1166130007283 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1166130007284 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1166130007285 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 1166130007286 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1166130007287 GTPase CgtA; Reviewed; Region: obgE; PRK12298 1166130007288 GTP1/OBG; Region: GTP1_OBG; pfam01018 1166130007289 Obg GTPase; Region: Obg; cd01898 1166130007290 G1 box; other site 1166130007291 GTP/Mg2+ binding site [chemical binding]; other site 1166130007292 Switch I region; other site 1166130007293 G2 box; other site 1166130007294 G3 box; other site 1166130007295 Switch II region; other site 1166130007296 G4 box; other site 1166130007297 G5 box; other site 1166130007298 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1166130007299 EamA-like transporter family; Region: EamA; pfam00892 1166130007300 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1166130007301 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1166130007302 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1166130007303 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1166130007304 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1166130007305 substrate binding pocket [chemical binding]; other site 1166130007306 chain length determination region; other site 1166130007307 substrate-Mg2+ binding site; other site 1166130007308 catalytic residues [active] 1166130007309 aspartate-rich region 1; other site 1166130007310 active site lid residues [active] 1166130007311 aspartate-rich region 2; other site 1166130007312 Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423 1166130007313 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1166130007314 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1166130007315 hinge; other site 1166130007316 active site 1166130007317 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 1166130007318 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1166130007319 anti sigma factor interaction site; other site 1166130007320 regulatory phosphorylation site [posttranslational modification]; other site 1166130007321 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 1166130007322 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1166130007323 mce related protein; Region: MCE; pfam02470 1166130007324 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1166130007325 conserved hypothetical integral membrane protein; Region: TIGR00056 1166130007326 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 1166130007327 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1166130007328 Walker A/P-loop; other site 1166130007329 ATP binding site [chemical binding]; other site 1166130007330 Q-loop/lid; other site 1166130007331 ABC transporter signature motif; other site 1166130007332 Walker B; other site 1166130007333 D-loop; other site 1166130007334 H-loop/switch region; other site 1166130007335 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 1166130007336 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1166130007337 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1166130007338 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1166130007339 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1166130007340 putative active site [active] 1166130007341 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1166130007342 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 1166130007343 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1166130007344 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 1166130007345 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1166130007346 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 1166130007347 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 1166130007348 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 1166130007349 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1166130007350 Walker A/P-loop; other site 1166130007351 ATP binding site [chemical binding]; other site 1166130007352 Q-loop/lid; other site 1166130007353 ABC transporter signature motif; other site 1166130007354 Walker B; other site 1166130007355 D-loop; other site 1166130007356 H-loop/switch region; other site 1166130007357 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1166130007358 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1166130007359 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1166130007360 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1166130007361 30S subunit binding site; other site 1166130007362 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1166130007363 active site 1166130007364 phosphorylation site [posttranslational modification] 1166130007365 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 1166130007366 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1166130007367 dimerization domain swap beta strand [polypeptide binding]; other site 1166130007368 regulatory protein interface [polypeptide binding]; other site 1166130007369 active site 1166130007370 regulatory phosphorylation site [posttranslational modification]; other site 1166130007371 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 1166130007372 Transglycosylase; Region: Transgly; cl17702 1166130007373 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 1166130007374 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 1166130007375 conserved cys residue [active] 1166130007376 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 1166130007377 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1166130007378 putative active site [active] 1166130007379 heme pocket [chemical binding]; other site 1166130007380 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1166130007381 dimer interface [polypeptide binding]; other site 1166130007382 phosphorylation site [posttranslational modification] 1166130007383 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166130007384 ATP binding site [chemical binding]; other site 1166130007385 Mg2+ binding site [ion binding]; other site 1166130007386 G-X-G motif; other site 1166130007387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130007388 active site 1166130007389 phosphorylation site [posttranslational modification] 1166130007390 intermolecular recognition site; other site 1166130007391 dimerization interface [polypeptide binding]; other site 1166130007392 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1166130007393 putative binding surface; other site 1166130007394 active site 1166130007395 radical SAM protein, TIGR01212 family; Region: TIGR01212 1166130007396 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1166130007397 FeS/SAM binding site; other site 1166130007398 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1166130007399 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1166130007400 active site 1166130007401 dimer interface [polypeptide binding]; other site 1166130007402 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1166130007403 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1166130007404 active site 1166130007405 FMN binding site [chemical binding]; other site 1166130007406 substrate binding site [chemical binding]; other site 1166130007407 3Fe-4S cluster binding site [ion binding]; other site 1166130007408 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1166130007409 domain interface; other site 1166130007410 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 1166130007411 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1166130007412 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1166130007413 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1166130007414 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 1166130007415 stringent starvation protein A; Provisional; Region: sspA; PRK09481 1166130007416 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 1166130007417 C-terminal domain interface [polypeptide binding]; other site 1166130007418 putative GSH binding site (G-site) [chemical binding]; other site 1166130007419 dimer interface [polypeptide binding]; other site 1166130007420 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 1166130007421 dimer interface [polypeptide binding]; other site 1166130007422 N-terminal domain interface [polypeptide binding]; other site 1166130007423 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1166130007424 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1166130007425 23S rRNA interface [nucleotide binding]; other site 1166130007426 L3 interface [polypeptide binding]; other site 1166130007427 Predicted ATPase [General function prediction only]; Region: COG1485 1166130007428 hypothetical protein; Provisional; Region: PRK11677 1166130007429 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 1166130007430 serine endoprotease; Provisional; Region: PRK10139 1166130007431 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1166130007432 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1166130007433 protein binding site [polypeptide binding]; other site 1166130007434 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1166130007435 serine endoprotease; Provisional; Region: PRK10898 1166130007436 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1166130007437 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1166130007438 malate dehydrogenase; Provisional; Region: PRK05086 1166130007439 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 1166130007440 NAD binding site [chemical binding]; other site 1166130007441 dimerization interface [polypeptide binding]; other site 1166130007442 Substrate binding site [chemical binding]; other site 1166130007443 arginine repressor; Provisional; Region: PRK05066 1166130007444 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1166130007445 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1166130007446 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1166130007447 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1166130007448 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 1166130007449 RNAase interaction site [polypeptide binding]; other site 1166130007450 succinic semialdehyde dehydrogenase; Region: PLN02278 1166130007451 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1166130007452 tetramerization interface [polypeptide binding]; other site 1166130007453 NAD(P) binding site [chemical binding]; other site 1166130007454 catalytic residues [active] 1166130007455 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 1166130007456 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1166130007457 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 1166130007458 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1166130007459 HlyD family secretion protein; Region: HlyD_3; pfam13437 1166130007460 efflux system membrane protein; Provisional; Region: PRK11594 1166130007461 transcriptional regulator; Provisional; Region: PRK10632 1166130007462 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130007463 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1166130007464 putative effector binding pocket; other site 1166130007465 dimerization interface [polypeptide binding]; other site 1166130007466 protease TldD; Provisional; Region: tldD; PRK10735 1166130007467 hypothetical protein; Provisional; Region: PRK10899 1166130007468 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1166130007469 ribonuclease G; Provisional; Region: PRK11712 1166130007470 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1166130007471 homodimer interface [polypeptide binding]; other site 1166130007472 oligonucleotide binding site [chemical binding]; other site 1166130007473 Maf-like protein; Region: Maf; pfam02545 1166130007474 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1166130007475 active site 1166130007476 dimer interface [polypeptide binding]; other site 1166130007477 rod shape-determining protein MreD; Provisional; Region: PRK11060 1166130007478 rod shape-determining protein MreC; Region: mreC; TIGR00219 1166130007479 rod shape-determining protein MreC; Region: MreC; pfam04085 1166130007480 rod shape-determining protein MreB; Provisional; Region: PRK13927 1166130007481 MreB and similar proteins; Region: MreB_like; cd10225 1166130007482 nucleotide binding site [chemical binding]; other site 1166130007483 Mg binding site [ion binding]; other site 1166130007484 putative protofilament interaction site [polypeptide binding]; other site 1166130007485 RodZ interaction site [polypeptide binding]; other site 1166130007486 regulatory protein CsrD; Provisional; Region: PRK11059 1166130007487 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166130007488 metal binding site [ion binding]; metal-binding site 1166130007489 active site 1166130007490 I-site; other site 1166130007491 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1166130007492 TMAO/DMSO reductase; Reviewed; Region: PRK05363 1166130007493 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 1166130007494 Moco binding site; other site 1166130007495 metal coordination site [ion binding]; other site 1166130007496 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 1166130007497 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1166130007498 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1166130007499 trimer interface [polypeptide binding]; other site 1166130007500 active site 1166130007501 dimer interface [polypeptide binding]; other site 1166130007502 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1166130007503 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1166130007504 carboxyltransferase (CT) interaction site; other site 1166130007505 biotinylation site [posttranslational modification]; other site 1166130007506 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1166130007507 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1166130007508 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1166130007509 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1166130007510 hypothetical protein; Provisional; Region: PRK10633 1166130007511 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 1166130007512 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1166130007513 Na binding site [ion binding]; other site 1166130007514 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1166130007515 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1166130007516 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1166130007517 active site 1166130007518 FMN binding site [chemical binding]; other site 1166130007519 catalytic residues [active] 1166130007520 substrate binding site [chemical binding]; other site 1166130007521 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 1166130007522 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 1166130007523 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 1166130007524 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1166130007525 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1166130007526 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1166130007527 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166130007528 metal binding site [ion binding]; metal-binding site 1166130007529 active site 1166130007530 I-site; other site 1166130007531 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1166130007532 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1166130007533 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1166130007534 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166130007535 substrate binding pocket [chemical binding]; other site 1166130007536 membrane-bound complex binding site; other site 1166130007537 hinge residues; other site 1166130007538 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 1166130007539 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1166130007540 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130007541 dimer interface [polypeptide binding]; other site 1166130007542 ABC-ATPase subunit interface; other site 1166130007543 putative PBP binding loops; other site 1166130007544 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130007545 dimer interface [polypeptide binding]; other site 1166130007546 conserved gate region; other site 1166130007547 putative PBP binding loops; other site 1166130007548 ABC-ATPase subunit interface; other site 1166130007549 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1166130007550 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1166130007551 Walker A/P-loop; other site 1166130007552 ATP binding site [chemical binding]; other site 1166130007553 Q-loop/lid; other site 1166130007554 ABC transporter signature motif; other site 1166130007555 Walker B; other site 1166130007556 D-loop; other site 1166130007557 H-loop/switch region; other site 1166130007558 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1166130007559 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1166130007560 trimer interface [polypeptide binding]; other site 1166130007561 putative metal binding site [ion binding]; other site 1166130007562 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 1166130007563 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1166130007564 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1166130007565 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1166130007566 shikimate binding site; other site 1166130007567 NAD(P) binding site [chemical binding]; other site 1166130007568 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 1166130007569 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1166130007570 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1166130007571 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1166130007572 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1166130007573 hypothetical protein; Validated; Region: PRK03430 1166130007574 hypothetical protein; Provisional; Region: PRK10736 1166130007575 DNA protecting protein DprA; Region: dprA; TIGR00732 1166130007576 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1166130007577 active site 1166130007578 catalytic residues [active] 1166130007579 metal binding site [ion binding]; metal-binding site 1166130007580 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1166130007581 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1166130007582 putative active site [active] 1166130007583 substrate binding site [chemical binding]; other site 1166130007584 putative cosubstrate binding site; other site 1166130007585 catalytic site [active] 1166130007586 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1166130007587 substrate binding site [chemical binding]; other site 1166130007588 16S rRNA methyltransferase B; Provisional; Region: PRK10901 1166130007589 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1166130007590 putative RNA binding site [nucleotide binding]; other site 1166130007591 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166130007592 S-adenosylmethionine binding site [chemical binding]; other site 1166130007593 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1166130007594 TrkA-N domain; Region: TrkA_N; pfam02254 1166130007595 TrkA-C domain; Region: TrkA_C; pfam02080 1166130007596 TrkA-N domain; Region: TrkA_N; pfam02254 1166130007597 TrkA-C domain; Region: TrkA_C; pfam02080 1166130007598 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1166130007599 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1166130007600 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 1166130007601 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 1166130007602 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1166130007603 DNA binding residues [nucleotide binding] 1166130007604 dimer interface [polypeptide binding]; other site 1166130007605 metal binding site [ion binding]; metal-binding site 1166130007606 hypothetical protein; Provisional; Region: PRK10203 1166130007607 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1166130007608 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1166130007609 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1166130007610 alphaNTD homodimer interface [polypeptide binding]; other site 1166130007611 alphaNTD - beta interaction site [polypeptide binding]; other site 1166130007612 alphaNTD - beta' interaction site [polypeptide binding]; other site 1166130007613 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1166130007614 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1166130007615 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1166130007616 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1166130007617 RNA binding surface [nucleotide binding]; other site 1166130007618 30S ribosomal protein S11; Validated; Region: PRK05309 1166130007619 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1166130007620 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1166130007621 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 1166130007622 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1166130007623 SecY translocase; Region: SecY; pfam00344 1166130007624 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1166130007625 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1166130007626 23S rRNA binding site [nucleotide binding]; other site 1166130007627 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1166130007628 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1166130007629 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1166130007630 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1166130007631 23S rRNA interface [nucleotide binding]; other site 1166130007632 5S rRNA interface [nucleotide binding]; other site 1166130007633 L27 interface [polypeptide binding]; other site 1166130007634 L5 interface [polypeptide binding]; other site 1166130007635 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1166130007636 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1166130007637 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1166130007638 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1166130007639 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1166130007640 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1166130007641 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1166130007642 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1166130007643 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1166130007644 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1166130007645 RNA binding site [nucleotide binding]; other site 1166130007646 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1166130007647 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1166130007648 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1166130007649 23S rRNA interface [nucleotide binding]; other site 1166130007650 putative translocon interaction site; other site 1166130007651 signal recognition particle (SRP54) interaction site; other site 1166130007652 L23 interface [polypeptide binding]; other site 1166130007653 trigger factor interaction site; other site 1166130007654 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1166130007655 23S rRNA interface [nucleotide binding]; other site 1166130007656 5S rRNA interface [nucleotide binding]; other site 1166130007657 putative antibiotic binding site [chemical binding]; other site 1166130007658 L25 interface [polypeptide binding]; other site 1166130007659 L27 interface [polypeptide binding]; other site 1166130007660 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1166130007661 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1166130007662 G-X-X-G motif; other site 1166130007663 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1166130007664 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1166130007665 protein-rRNA interface [nucleotide binding]; other site 1166130007666 putative translocon binding site; other site 1166130007667 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1166130007668 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1166130007669 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1166130007670 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1166130007671 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1166130007672 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1166130007673 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 1166130007674 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1166130007675 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1166130007676 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1166130007677 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1166130007678 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1166130007679 heme binding site [chemical binding]; other site 1166130007680 ferroxidase pore; other site 1166130007681 ferroxidase diiron center [ion binding]; other site 1166130007682 elongation factor Tu; Reviewed; Region: PRK00049 1166130007683 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1166130007684 G1 box; other site 1166130007685 GEF interaction site [polypeptide binding]; other site 1166130007686 GTP/Mg2+ binding site [chemical binding]; other site 1166130007687 Switch I region; other site 1166130007688 G2 box; other site 1166130007689 G3 box; other site 1166130007690 Switch II region; other site 1166130007691 G4 box; other site 1166130007692 G5 box; other site 1166130007693 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1166130007694 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1166130007695 Antibiotic Binding Site [chemical binding]; other site 1166130007696 elongation factor G; Reviewed; Region: PRK00007 1166130007697 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1166130007698 G1 box; other site 1166130007699 putative GEF interaction site [polypeptide binding]; other site 1166130007700 GTP/Mg2+ binding site [chemical binding]; other site 1166130007701 Switch I region; other site 1166130007702 G2 box; other site 1166130007703 G3 box; other site 1166130007704 Switch II region; other site 1166130007705 G4 box; other site 1166130007706 G5 box; other site 1166130007707 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1166130007708 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1166130007709 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1166130007710 30S ribosomal protein S7; Validated; Region: PRK05302 1166130007711 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1166130007712 S17 interaction site [polypeptide binding]; other site 1166130007713 S8 interaction site; other site 1166130007714 16S rRNA interaction site [nucleotide binding]; other site 1166130007715 streptomycin interaction site [chemical binding]; other site 1166130007716 23S rRNA interaction site [nucleotide binding]; other site 1166130007717 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1166130007718 DsrH like protein; Region: DsrH; cl17347 1166130007719 sulfur relay protein TusC; Validated; Region: PRK00211 1166130007720 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 1166130007721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1166130007722 YheO-like PAS domain; Region: PAS_6; pfam08348 1166130007723 HTH domain; Region: HTH_22; pfam13309 1166130007724 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 1166130007725 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1166130007726 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1166130007727 phi X174 lysis protein; Provisional; Region: PRK02793 1166130007728 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1166130007729 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1166130007730 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 1166130007731 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 1166130007732 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1166130007733 TrkA-N domain; Region: TrkA_N; pfam02254 1166130007734 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 1166130007735 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 1166130007736 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166130007737 Walker A/P-loop; other site 1166130007738 ATP binding site [chemical binding]; other site 1166130007739 Q-loop/lid; other site 1166130007740 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1166130007741 ABC transporter; Region: ABC_tran_2; pfam12848 1166130007742 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1166130007743 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1166130007744 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166130007745 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130007746 The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416 1166130007747 putative dimerization interface [polypeptide binding]; other site 1166130007748 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1166130007749 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 1166130007750 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 1166130007751 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 1166130007752 Membrane transport protein; Region: Mem_trans; cl09117 1166130007753 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; pfam06833 1166130007754 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 1166130007755 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 1166130007756 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 1166130007757 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 1166130007758 Coenzyme A transferase; Region: CoA_trans; cl17247 1166130007759 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 1166130007760 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 1166130007761 active site 1166130007762 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 1166130007763 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1166130007764 active site 1166130007765 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1166130007766 nudix motif; other site 1166130007767 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1166130007768 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 1166130007769 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1166130007770 putative hydrolase; Provisional; Region: PRK10985 1166130007771 hypothetical protein; Provisional; Region: PRK04966 1166130007772 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 1166130007773 active site 1166130007774 hypothetical protein; Provisional; Region: PRK10738 1166130007775 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 1166130007776 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1166130007777 ligand binding site [chemical binding]; other site 1166130007778 flexible hinge region; other site 1166130007779 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1166130007780 putative switch regulator; other site 1166130007781 non-specific DNA interactions [nucleotide binding]; other site 1166130007782 DNA binding site [nucleotide binding] 1166130007783 sequence specific DNA binding site [nucleotide binding]; other site 1166130007784 putative cAMP binding site [chemical binding]; other site 1166130007785 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 1166130007786 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1166130007787 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1166130007788 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 1166130007789 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1166130007790 inhibitor-cofactor binding pocket; inhibition site 1166130007791 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130007792 catalytic residue [active] 1166130007793 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1166130007794 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1166130007795 glutamine binding [chemical binding]; other site 1166130007796 catalytic triad [active] 1166130007797 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 1166130007798 cell filamentation protein Fic; Provisional; Region: PRK10347 1166130007799 hypothetical protein; Provisional; Region: PRK10204 1166130007800 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 1166130007801 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1166130007802 substrate binding site [chemical binding]; other site 1166130007803 cytosine deaminase; Provisional; Region: PRK09230 1166130007804 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1166130007805 active site 1166130007806 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1166130007807 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1166130007808 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1166130007809 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1166130007810 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1166130007811 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1166130007812 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 1166130007813 siroheme synthase; Provisional; Region: cysG; PRK10637 1166130007814 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1166130007815 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1166130007816 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1166130007817 active site 1166130007818 SAM binding site [chemical binding]; other site 1166130007819 homodimer interface [polypeptide binding]; other site 1166130007820 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1166130007821 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1166130007822 active site 1166130007823 HIGH motif; other site 1166130007824 dimer interface [polypeptide binding]; other site 1166130007825 KMSKS motif; other site 1166130007826 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1166130007827 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1166130007828 motif II; other site 1166130007829 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1166130007830 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1166130007831 substrate binding site [chemical binding]; other site 1166130007832 hexamer interface [polypeptide binding]; other site 1166130007833 metal binding site [ion binding]; metal-binding site 1166130007834 DNA adenine methylase; Provisional; Region: PRK10904 1166130007835 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 1166130007836 cell division protein DamX; Validated; Region: PRK10905 1166130007837 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1166130007838 active site 1166130007839 dimer interface [polypeptide binding]; other site 1166130007840 metal binding site [ion binding]; metal-binding site 1166130007841 shikimate kinase; Reviewed; Region: aroK; PRK00131 1166130007842 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1166130007843 ADP binding site [chemical binding]; other site 1166130007844 magnesium binding site [ion binding]; other site 1166130007845 putative shikimate binding site; other site 1166130007846 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 1166130007847 Secretin and TonB N terminus short domain; Region: STN; smart00965 1166130007848 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1166130007849 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1166130007850 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 1166130007851 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 1166130007852 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1166130007853 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 1166130007854 Transglycosylase; Region: Transgly; pfam00912 1166130007855 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1166130007856 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 1166130007857 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1166130007858 dimer interface [polypeptide binding]; other site 1166130007859 ADP-ribose binding site [chemical binding]; other site 1166130007860 active site 1166130007861 nudix motif; other site 1166130007862 metal binding site [ion binding]; metal-binding site 1166130007863 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 1166130007864 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1166130007865 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1166130007866 motif II; other site 1166130007867 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1166130007868 RNA binding surface [nucleotide binding]; other site 1166130007869 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1166130007870 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1166130007871 dimerization interface [polypeptide binding]; other site 1166130007872 domain crossover interface; other site 1166130007873 redox-dependent activation switch; other site 1166130007874 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1166130007875 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1166130007876 active site 1166130007877 substrate-binding site [chemical binding]; other site 1166130007878 metal-binding site [ion binding] 1166130007879 ATP binding site [chemical binding]; other site 1166130007880 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 1166130007881 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166130007882 dimerization interface [polypeptide binding]; other site 1166130007883 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1166130007884 dimer interface [polypeptide binding]; other site 1166130007885 phosphorylation site [posttranslational modification] 1166130007886 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166130007887 ATP binding site [chemical binding]; other site 1166130007888 G-X-G motif; other site 1166130007889 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1166130007890 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130007891 active site 1166130007892 phosphorylation site [posttranslational modification] 1166130007893 intermolecular recognition site; other site 1166130007894 dimerization interface [polypeptide binding]; other site 1166130007895 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1166130007896 DNA binding site [nucleotide binding] 1166130007897 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1166130007898 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1166130007899 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1166130007900 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1166130007901 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1166130007902 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1166130007903 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1166130007904 RNA binding site [nucleotide binding]; other site 1166130007905 FeoA domain; Region: FeoA; cl00838 1166130007906 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 1166130007907 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1166130007908 G1 box; other site 1166130007909 GTP/Mg2+ binding site [chemical binding]; other site 1166130007910 Switch I region; other site 1166130007911 G2 box; other site 1166130007912 G3 box; other site 1166130007913 Switch II region; other site 1166130007914 G4 box; other site 1166130007915 G5 box; other site 1166130007916 Nucleoside recognition; Region: Gate; pfam07670 1166130007917 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1166130007918 Nucleoside recognition; Region: Gate; pfam07670 1166130007919 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 1166130007920 carboxylesterase BioH; Provisional; Region: PRK10349 1166130007921 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1166130007922 DNA utilization protein GntX; Provisional; Region: PRK11595 1166130007923 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1166130007924 active site 1166130007925 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 1166130007926 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1166130007927 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1166130007928 high-affinity gluconate transporter; Provisional; Region: PRK14984 1166130007929 gluconate transporter; Region: gntP; TIGR00791 1166130007930 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1166130007931 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 1166130007932 maltodextrin phosphorylase; Provisional; Region: PRK14985 1166130007933 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1166130007934 active site pocket [active] 1166130007935 transcriptional regulator MalT; Provisional; Region: PRK04841 1166130007936 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1166130007937 DNA binding residues [nucleotide binding] 1166130007938 dimerization interface [polypeptide binding]; other site 1166130007939 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 1166130007940 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1166130007941 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1166130007942 intramembrane serine protease GlpG; Provisional; Region: PRK10907 1166130007943 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 1166130007944 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1166130007945 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 1166130007946 active site residue [active] 1166130007947 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 1166130007948 glycogen phosphorylase; Provisional; Region: PRK14986 1166130007949 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1166130007950 homodimer interface [polypeptide binding]; other site 1166130007951 active site pocket [active] 1166130007952 glycogen synthase; Provisional; Region: glgA; PRK00654 1166130007953 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1166130007954 ADP-binding pocket [chemical binding]; other site 1166130007955 homodimer interface [polypeptide binding]; other site 1166130007956 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 1166130007957 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1166130007958 ligand binding site; other site 1166130007959 oligomer interface; other site 1166130007960 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1166130007961 sulfate 1 binding site; other site 1166130007962 glycogen debranching enzyme; Provisional; Region: PRK03705 1166130007963 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1166130007964 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1166130007965 active site 1166130007966 catalytic site [active] 1166130007967 glycogen branching enzyme; Provisional; Region: PRK05402 1166130007968 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1166130007969 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1166130007970 active site 1166130007971 catalytic site [active] 1166130007972 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1166130007973 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1166130007974 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1166130007975 putative antibiotic transporter; Provisional; Region: PRK10739 1166130007976 low affinity gluconate transporter; Provisional; Region: PRK10472 1166130007977 gluconate transporter; Region: gntP; TIGR00791 1166130007978 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1166130007979 Shikimate kinase; Region: SKI; pfam01202 1166130007980 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 1166130007981 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1166130007982 DNA binding site [nucleotide binding] 1166130007983 domain linker motif; other site 1166130007984 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1166130007985 putative ligand binding site [chemical binding]; other site 1166130007986 putative dimerization interface [polypeptide binding]; other site 1166130007987 Pirin-related protein [General function prediction only]; Region: COG1741 1166130007988 Pirin; Region: Pirin; pfam02678 1166130007989 putative oxidoreductase; Provisional; Region: PRK10206 1166130007990 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1166130007991 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1166130007992 putative acetyltransferase YhhY; Provisional; Region: PRK10140 1166130007993 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166130007994 Coenzyme A binding pocket [chemical binding]; other site 1166130007995 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 1166130007996 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1166130007997 hypothetical protein; Provisional; Region: PRK10350 1166130007998 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 1166130007999 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 1166130008000 putative active site [active] 1166130008001 catalytic site [active] 1166130008002 putative metal binding site [ion binding]; other site 1166130008003 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1166130008004 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1166130008005 Walker A/P-loop; other site 1166130008006 ATP binding site [chemical binding]; other site 1166130008007 Q-loop/lid; other site 1166130008008 ABC transporter signature motif; other site 1166130008009 Walker B; other site 1166130008010 D-loop; other site 1166130008011 H-loop/switch region; other site 1166130008012 TOBE domain; Region: TOBE_2; pfam08402 1166130008013 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1166130008014 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130008015 dimer interface [polypeptide binding]; other site 1166130008016 conserved gate region; other site 1166130008017 putative PBP binding loops; other site 1166130008018 ABC-ATPase subunit interface; other site 1166130008019 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1166130008020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130008021 putative PBP binding loops; other site 1166130008022 dimer interface [polypeptide binding]; other site 1166130008023 ABC-ATPase subunit interface; other site 1166130008024 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 1166130008025 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1166130008026 small toxic polypeptide; Provisional; Region: PRK09738 1166130008027 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 1166130008028 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1166130008029 Walker A/P-loop; other site 1166130008030 ATP binding site [chemical binding]; other site 1166130008031 Q-loop/lid; other site 1166130008032 ABC transporter signature motif; other site 1166130008033 Walker B; other site 1166130008034 D-loop; other site 1166130008035 H-loop/switch region; other site 1166130008036 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1166130008037 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1166130008038 Walker A/P-loop; other site 1166130008039 ATP binding site [chemical binding]; other site 1166130008040 Q-loop/lid; other site 1166130008041 ABC transporter signature motif; other site 1166130008042 Walker B; other site 1166130008043 D-loop; other site 1166130008044 H-loop/switch region; other site 1166130008045 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1166130008046 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1166130008047 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1166130008048 TM-ABC transporter signature motif; other site 1166130008049 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1166130008050 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1166130008051 TM-ABC transporter signature motif; other site 1166130008052 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1166130008053 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1166130008054 dimerization interface [polypeptide binding]; other site 1166130008055 ligand binding site [chemical binding]; other site 1166130008056 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 1166130008057 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1166130008058 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1166130008059 dimerization interface [polypeptide binding]; other site 1166130008060 ligand binding site [chemical binding]; other site 1166130008061 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 1166130008062 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1166130008063 inhibitor-cofactor binding pocket; inhibition site 1166130008064 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130008065 catalytic residue [active] 1166130008066 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1166130008067 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1166130008068 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1166130008069 DNA binding residues [nucleotide binding] 1166130008070 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 1166130008071 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1166130008072 cell division protein FtsE; Provisional; Region: PRK10908 1166130008073 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166130008074 Walker A/P-loop; other site 1166130008075 ATP binding site [chemical binding]; other site 1166130008076 Q-loop/lid; other site 1166130008077 ABC transporter signature motif; other site 1166130008078 Walker B; other site 1166130008079 D-loop; other site 1166130008080 H-loop/switch region; other site 1166130008081 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1166130008082 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1166130008083 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1166130008084 P loop; other site 1166130008085 GTP binding site [chemical binding]; other site 1166130008086 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1166130008087 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166130008088 S-adenosylmethionine binding site [chemical binding]; other site 1166130008089 hypothetical protein; Provisional; Region: PRK10910 1166130008090 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 1166130008091 Predicted membrane protein [Function unknown]; Region: COG3714 1166130008092 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 1166130008093 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1166130008094 metal-binding site [ion binding] 1166130008095 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1166130008096 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1166130008097 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 1166130008098 CPxP motif; other site 1166130008099 hypothetical protein; Provisional; Region: PRK11212 1166130008100 hypothetical protein; Provisional; Region: PRK11615 1166130008101 major facilitator superfamily transporter; Provisional; Region: PRK05122 1166130008102 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130008103 putative substrate translocation pore; other site 1166130008104 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1166130008105 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1166130008106 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 1166130008107 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 1166130008108 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 1166130008109 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1166130008110 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 1166130008111 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 1166130008112 putative active site [active] 1166130008113 putative catalytic site [active] 1166130008114 putative Zn binding site [ion binding]; other site 1166130008115 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 1166130008116 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1166130008117 active site 1166130008118 substrate binding site [chemical binding]; other site 1166130008119 cosubstrate binding site; other site 1166130008120 catalytic site [active] 1166130008121 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 1166130008122 active site 1166130008123 hexamer interface [polypeptide binding]; other site 1166130008124 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 1166130008125 NAD binding site [chemical binding]; other site 1166130008126 substrate binding site [chemical binding]; other site 1166130008127 active site 1166130008128 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1166130008129 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1166130008130 Ligand binding site; other site 1166130008131 Putative Catalytic site; other site 1166130008132 DXD motif; other site 1166130008133 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1166130008134 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1166130008135 inhibitor-cofactor binding pocket; inhibition site 1166130008136 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130008137 catalytic residue [active] 1166130008138 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; pfam05870 1166130008139 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166130008140 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130008141 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1166130008142 dimerization interface [polypeptide binding]; other site 1166130008143 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1166130008144 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 1166130008145 substrate binding site [chemical binding]; other site 1166130008146 nickel transporter permease NikB; Provisional; Region: PRK10352 1166130008147 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130008148 dimer interface [polypeptide binding]; other site 1166130008149 conserved gate region; other site 1166130008150 putative PBP binding loops; other site 1166130008151 ABC-ATPase subunit interface; other site 1166130008152 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 1166130008153 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130008154 dimer interface [polypeptide binding]; other site 1166130008155 conserved gate region; other site 1166130008156 putative PBP binding loops; other site 1166130008157 ABC-ATPase subunit interface; other site 1166130008158 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 1166130008159 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1166130008160 Walker A/P-loop; other site 1166130008161 ATP binding site [chemical binding]; other site 1166130008162 Q-loop/lid; other site 1166130008163 ABC transporter signature motif; other site 1166130008164 Walker B; other site 1166130008165 D-loop; other site 1166130008166 H-loop/switch region; other site 1166130008167 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 1166130008168 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1166130008169 Walker A/P-loop; other site 1166130008170 ATP binding site [chemical binding]; other site 1166130008171 Q-loop/lid; other site 1166130008172 ABC transporter signature motif; other site 1166130008173 Walker B; other site 1166130008174 D-loop; other site 1166130008175 H-loop/switch region; other site 1166130008176 nickel responsive regulator; Provisional; Region: PRK02967 1166130008177 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 1166130008178 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1166130008179 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1166130008180 NAD(P) binding site [chemical binding]; other site 1166130008181 active site 1166130008182 Predicted permeases [General function prediction only]; Region: COG0679 1166130008183 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 1166130008184 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 1166130008185 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 1166130008186 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1166130008187 PAAR motif; Region: PAAR_motif; pfam05488 1166130008188 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1166130008189 RHS Repeat; Region: RHS_repeat; cl11982 1166130008190 RHS Repeat; Region: RHS_repeat; pfam05593 1166130008191 RHS Repeat; Region: RHS_repeat; cl11982 1166130008192 RHS Repeat; Region: RHS_repeat; pfam05593 1166130008193 RHS Repeat; Region: RHS_repeat; cl11982 1166130008194 RHS protein; Region: RHS; pfam03527 1166130008195 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1166130008196 HNH/ENDO VII superfamily nuclease with conserved GHE residues; Region: GH-E; pfam14410 1166130008197 Domain of unknown function (DUF1795); Region: DUF1795; cl02256 1166130008198 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1166130008199 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1166130008200 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1166130008201 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1166130008202 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 1166130008203 Predicted flavoproteins [General function prediction only]; Region: COG2081 1166130008204 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1166130008205 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1166130008206 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1166130008207 universal stress protein UspB; Provisional; Region: PRK04960 1166130008208 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1166130008209 Ligand Binding Site [chemical binding]; other site 1166130008210 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166130008211 S-adenosylmethionine binding site [chemical binding]; other site 1166130008212 oligopeptidase A; Provisional; Region: PRK10911 1166130008213 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1166130008214 active site 1166130008215 Zn binding site [ion binding]; other site 1166130008216 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1166130008217 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 1166130008218 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1166130008219 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1166130008220 glutathione reductase; Validated; Region: PRK06116 1166130008221 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1166130008222 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1166130008223 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1166130008224 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1166130008225 catalytic core [active] 1166130008226 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166130008227 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130008228 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1166130008229 substrate binding pocket [chemical binding]; other site 1166130008230 dimerization interface [polypeptide binding]; other site 1166130008231 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 1166130008232 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 1166130008233 putative active site; other site 1166130008234 catalytic triad [active] 1166130008235 putative dimer interface [polypeptide binding]; other site 1166130008236 agmatine deiminase; Region: agmatine_aguA; TIGR03380 1166130008237 agmatine deiminase; Provisional; Region: PRK13551 1166130008238 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1166130008239 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166130008240 Coenzyme A binding pocket [chemical binding]; other site 1166130008241 trehalase; Provisional; Region: treF; PRK13270 1166130008242 Trehalase; Region: Trehalase; pfam01204 1166130008243 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1166130008244 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1166130008245 Coenzyme A binding pocket [chemical binding]; other site 1166130008246 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 1166130008247 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1166130008248 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1166130008249 NAD(P) binding site [chemical binding]; other site 1166130008250 active site 1166130008251 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166130008252 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130008253 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1166130008254 putative effector binding pocket; other site 1166130008255 putative dimerization interface [polypeptide binding]; other site 1166130008256 inner membrane protein YhjD; Region: TIGR00766 1166130008257 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130008258 metabolite-proton symporter; Region: 2A0106; TIGR00883 1166130008259 putative substrate translocation pore; other site 1166130008260 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1166130008261 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1166130008262 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1166130008263 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1166130008264 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1166130008265 substrate binding site [chemical binding]; other site 1166130008266 ATP binding site [chemical binding]; other site 1166130008267 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1166130008268 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1166130008269 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1166130008270 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1166130008271 putative diguanylate cyclase; Provisional; Region: PRK13561 1166130008272 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166130008273 metal binding site [ion binding]; metal-binding site 1166130008274 active site 1166130008275 I-site; other site 1166130008276 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1166130008277 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 1166130008278 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1166130008279 TPR motif; other site 1166130008280 binding surface 1166130008281 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1166130008282 binding surface 1166130008283 TPR motif; other site 1166130008284 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 1166130008285 endo-1,4-D-glucanase; Provisional; Region: PRK11097 1166130008286 cellulose synthase regulator protein; Provisional; Region: PRK11114 1166130008287 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 1166130008288 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1166130008289 DXD motif; other site 1166130008290 PilZ domain; Region: PilZ; pfam07238 1166130008291 cell division protein; Provisional; Region: PRK10037 1166130008292 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1166130008293 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 1166130008294 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 1166130008295 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 1166130008296 Protein of unknown function (DUF2636); Region: DUF2636; pfam11120 1166130008297 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 1166130008298 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 1166130008299 Cellulose synthase subunit D; Region: Cellsynth_D; pfam03500 1166130008300 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 1166130008301 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1166130008302 TPR motif; other site 1166130008303 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1166130008304 binding surface 1166130008305 TPR motif; other site 1166130008306 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 1166130008307 cellulose synthase regulator protein; Provisional; Region: PRK11114 1166130008308 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 1166130008309 Cellulose synthase-like protein; Region: PLN02893 1166130008310 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1166130008311 DXD motif; other site 1166130008312 PilZ domain; Region: PilZ; pfam07238 1166130008313 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1166130008314 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1166130008315 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1166130008316 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1166130008317 Walker A/P-loop; other site 1166130008318 ATP binding site [chemical binding]; other site 1166130008319 Q-loop/lid; other site 1166130008320 ABC transporter signature motif; other site 1166130008321 Walker B; other site 1166130008322 D-loop; other site 1166130008323 H-loop/switch region; other site 1166130008324 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1166130008325 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 1166130008326 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1166130008327 Walker A/P-loop; other site 1166130008328 ATP binding site [chemical binding]; other site 1166130008329 Q-loop/lid; other site 1166130008330 ABC transporter signature motif; other site 1166130008331 Walker B; other site 1166130008332 D-loop; other site 1166130008333 H-loop/switch region; other site 1166130008334 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1166130008335 dipeptide transporter; Provisional; Region: PRK10913 1166130008336 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1166130008337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130008338 dimer interface [polypeptide binding]; other site 1166130008339 conserved gate region; other site 1166130008340 putative PBP binding loops; other site 1166130008341 ABC-ATPase subunit interface; other site 1166130008342 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1166130008343 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130008344 dimer interface [polypeptide binding]; other site 1166130008345 conserved gate region; other site 1166130008346 putative PBP binding loops; other site 1166130008347 ABC-ATPase subunit interface; other site 1166130008348 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1166130008349 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1166130008350 peptide binding site [polypeptide binding]; other site 1166130008351 phosphoethanolamine transferase; Provisional; Region: PRK11560 1166130008352 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1166130008353 Sulfatase; Region: Sulfatase; pfam00884 1166130008354 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1166130008355 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1166130008356 Autotransporter beta-domain; Region: Autotransporter; cl17461 1166130008357 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 1166130008358 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1166130008359 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166130008360 Coenzyme A binding pocket [chemical binding]; other site 1166130008361 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1166130008362 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1166130008363 molybdopterin cofactor binding site [chemical binding]; other site 1166130008364 substrate binding site [chemical binding]; other site 1166130008365 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1166130008366 molybdopterin cofactor binding site; other site 1166130008367 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1166130008368 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1166130008369 DNA binding site [nucleotide binding] 1166130008370 domain linker motif; other site 1166130008371 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1166130008372 putative dimerization interface [polypeptide binding]; other site 1166130008373 putative ligand binding site [chemical binding]; other site 1166130008374 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1166130008375 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1166130008376 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1166130008377 substrate binding site [chemical binding]; other site 1166130008378 ATP binding site [chemical binding]; other site 1166130008379 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130008380 D-galactonate transporter; Region: 2A0114; TIGR00893 1166130008381 putative substrate translocation pore; other site 1166130008382 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1166130008383 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1166130008384 dimerization interface [polypeptide binding]; other site 1166130008385 ligand binding site [chemical binding]; other site 1166130008386 NADP binding site [chemical binding]; other site 1166130008387 catalytic site [active] 1166130008388 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 1166130008389 Predicted transcriptional regulator [Transcription]; Region: COG2944 1166130008390 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1166130008391 salt bridge; other site 1166130008392 non-specific DNA binding site [nucleotide binding]; other site 1166130008393 sequence-specific DNA binding site [nucleotide binding]; other site 1166130008394 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1166130008395 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166130008396 Walker A/P-loop; other site 1166130008397 ATP binding site [chemical binding]; other site 1166130008398 Q-loop/lid; other site 1166130008399 ABC transporter signature motif; other site 1166130008400 Walker B; other site 1166130008401 D-loop; other site 1166130008402 H-loop/switch region; other site 1166130008403 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1166130008404 Response regulator receiver domain; Region: Response_reg; pfam00072 1166130008405 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130008406 active site 1166130008407 phosphorylation site [posttranslational modification] 1166130008408 intermolecular recognition site; other site 1166130008409 dimerization interface [polypeptide binding]; other site 1166130008410 CheC-like family; Region: CheC; pfam04509 1166130008411 Chemotaxis phosphatase CheX; Region: CheX; cl15816 1166130008412 PAS fold; Region: PAS_4; pfam08448 1166130008413 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1166130008414 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166130008415 metal binding site [ion binding]; metal-binding site 1166130008416 active site 1166130008417 I-site; other site 1166130008418 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1166130008419 DALR anticodon binding domain; Region: DALR_1; pfam05746 1166130008420 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1166130008421 dimer interface [polypeptide binding]; other site 1166130008422 motif 1; other site 1166130008423 active site 1166130008424 motif 2; other site 1166130008425 motif 3; other site 1166130008426 YsaB-like lipoprotein; Region: YsaB; pfam13983 1166130008427 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1166130008428 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1166130008429 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1166130008430 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1166130008431 conserved cys residue [active] 1166130008432 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130008433 Isochorismatase family; Region: Isochorismatase; pfam00857 1166130008434 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1166130008435 catalytic triad [active] 1166130008436 conserved cis-peptide bond; other site 1166130008437 xylulokinase; Provisional; Region: PRK15027 1166130008438 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1166130008439 N- and C-terminal domain interface [polypeptide binding]; other site 1166130008440 active site 1166130008441 MgATP binding site [chemical binding]; other site 1166130008442 catalytic site [active] 1166130008443 metal binding site [ion binding]; metal-binding site 1166130008444 xylulose binding site [chemical binding]; other site 1166130008445 homodimer interface [polypeptide binding]; other site 1166130008446 xylose isomerase; Provisional; Region: PRK05474 1166130008447 xylose isomerase; Region: xylose_isom_A; TIGR02630 1166130008448 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 1166130008449 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1166130008450 putative ligand binding site [chemical binding]; other site 1166130008451 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 1166130008452 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1166130008453 Walker A/P-loop; other site 1166130008454 ATP binding site [chemical binding]; other site 1166130008455 Q-loop/lid; other site 1166130008456 ABC transporter signature motif; other site 1166130008457 Walker B; other site 1166130008458 D-loop; other site 1166130008459 H-loop/switch region; other site 1166130008460 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1166130008461 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1166130008462 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1166130008463 TM-ABC transporter signature motif; other site 1166130008464 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 1166130008465 putative dimerization interface [polypeptide binding]; other site 1166130008466 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1166130008467 putative ligand binding site [chemical binding]; other site 1166130008468 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130008469 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1166130008470 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130008471 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 1166130008472 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 1166130008473 alpha-amylase; Reviewed; Region: malS; PRK09505 1166130008474 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1166130008475 active site 1166130008476 Alpha amylase catalytic domain family; Region: AmyAc_family; cd00551 1166130008477 active site 1166130008478 catalytic site [active] 1166130008479 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 1166130008480 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1166130008481 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130008482 homodimer interface [polypeptide binding]; other site 1166130008483 catalytic residue [active] 1166130008484 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 1166130008485 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1166130008486 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 1166130008487 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 1166130008488 G1 box; other site 1166130008489 putative GEF interaction site [polypeptide binding]; other site 1166130008490 GTP/Mg2+ binding site [chemical binding]; other site 1166130008491 Switch I region; other site 1166130008492 G2 box; other site 1166130008493 G3 box; other site 1166130008494 Switch II region; other site 1166130008495 G4 box; other site 1166130008496 G5 box; other site 1166130008497 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 1166130008498 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 1166130008499 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 1166130008500 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 1166130008501 selenocysteine synthase; Provisional; Region: PRK04311 1166130008502 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 1166130008503 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 1166130008504 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1166130008505 catalytic residue [active] 1166130008506 putative glutathione S-transferase; Provisional; Region: PRK10357 1166130008507 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 1166130008508 putative C-terminal domain interface [polypeptide binding]; other site 1166130008509 putative GSH binding site (G-site) [chemical binding]; other site 1166130008510 putative dimer interface [polypeptide binding]; other site 1166130008511 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1166130008512 dimer interface [polypeptide binding]; other site 1166130008513 N-terminal domain interface [polypeptide binding]; other site 1166130008514 putative substrate binding pocket (H-site) [chemical binding]; other site 1166130008515 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 1166130008516 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1166130008517 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1166130008518 active site 1166130008519 P-loop; other site 1166130008520 phosphorylation site [posttranslational modification] 1166130008521 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1166130008522 active site 1166130008523 phosphorylation site [posttranslational modification] 1166130008524 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1166130008525 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1166130008526 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1166130008527 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 1166130008528 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 1166130008529 hypothetical protein; Provisional; Region: PRK11020 1166130008530 L-lactate permease; Provisional; Region: PRK10420 1166130008531 glycolate transporter; Provisional; Region: PRK09695 1166130008532 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 1166130008533 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166130008534 DNA-binding site [nucleotide binding]; DNA binding site 1166130008535 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1166130008536 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 1166130008537 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1166130008538 active site 1166130008539 substrate binding site [chemical binding]; other site 1166130008540 FMN binding site [chemical binding]; other site 1166130008541 putative catalytic residues [active] 1166130008542 putative rRNA methylase; Provisional; Region: PRK10358 1166130008543 serine acetyltransferase; Provisional; Region: cysE; PRK11132 1166130008544 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 1166130008545 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1166130008546 trimer interface [polypeptide binding]; other site 1166130008547 active site 1166130008548 substrate binding site [chemical binding]; other site 1166130008549 CoA binding site [chemical binding]; other site 1166130008550 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1166130008551 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1166130008552 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1166130008553 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 1166130008554 SecA binding site; other site 1166130008555 Preprotein binding site; other site 1166130008556 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1166130008557 GSH binding site [chemical binding]; other site 1166130008558 catalytic residues [active] 1166130008559 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1166130008560 active site residue [active] 1166130008561 phosphoglyceromutase; Provisional; Region: PRK05434 1166130008562 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1166130008563 AmiB activator; Provisional; Region: PRK11637 1166130008564 Peptidase family M23; Region: Peptidase_M23; pfam01551 1166130008565 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1166130008566 NodB motif; other site 1166130008567 putative active site [active] 1166130008568 putative catalytic site [active] 1166130008569 Zn binding site [ion binding]; other site 1166130008570 putative glycosyl transferase; Provisional; Region: PRK10073 1166130008571 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1166130008572 active site 1166130008573 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1166130008574 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1166130008575 NAD(P) binding site [chemical binding]; other site 1166130008576 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1166130008577 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1166130008578 substrate-cofactor binding pocket; other site 1166130008579 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130008580 catalytic residue [active] 1166130008581 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 1166130008582 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 1166130008583 NADP binding site [chemical binding]; other site 1166130008584 homopentamer interface [polypeptide binding]; other site 1166130008585 substrate binding site [chemical binding]; other site 1166130008586 active site 1166130008587 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1166130008588 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1166130008589 putative active site [active] 1166130008590 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1166130008591 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1166130008592 putative active site [active] 1166130008593 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1166130008594 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1166130008595 putative active site [active] 1166130008596 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1166130008597 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1166130008598 O-Antigen ligase; Region: Wzy_C; cl04850 1166130008599 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1166130008600 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1166130008601 putative active site [active] 1166130008602 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1166130008603 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1166130008604 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1166130008605 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1166130008606 lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484 1166130008607 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1166130008608 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1166130008609 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1166130008610 Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534 1166130008611 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1166130008612 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1166130008613 putative metal binding site; other site 1166130008614 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1166130008615 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1166130008616 active site 1166130008617 (T/H)XGH motif; other site 1166130008618 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1166130008619 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1166130008620 DNA binding site [nucleotide binding] 1166130008621 catalytic residue [active] 1166130008622 H2TH interface [polypeptide binding]; other site 1166130008623 putative catalytic residues [active] 1166130008624 turnover-facilitating residue; other site 1166130008625 intercalation triad [nucleotide binding]; other site 1166130008626 8OG recognition residue [nucleotide binding]; other site 1166130008627 putative reading head residues; other site 1166130008628 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1166130008629 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1166130008630 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1166130008631 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1166130008632 hypothetical protein; Reviewed; Region: PRK00024 1166130008633 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1166130008634 MPN+ (JAMM) motif; other site 1166130008635 Zinc-binding site [ion binding]; other site 1166130008636 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1166130008637 Flavoprotein; Region: Flavoprotein; pfam02441 1166130008638 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1166130008639 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1166130008640 trimer interface [polypeptide binding]; other site 1166130008641 active site 1166130008642 division inhibitor protein; Provisional; Region: slmA; PRK09480 1166130008643 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1166130008644 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1166130008645 Strictosidine synthase; Region: Str_synth; pfam03088 1166130008646 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1166130008647 active site 1166130008648 ribonuclease PH; Reviewed; Region: rph; PRK00173 1166130008649 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1166130008650 hexamer interface [polypeptide binding]; other site 1166130008651 active site 1166130008652 hypothetical protein; Provisional; Region: PRK11820 1166130008653 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1166130008654 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1166130008655 Predicted membrane protein [Function unknown]; Region: COG2860 1166130008656 UPF0126 domain; Region: UPF0126; pfam03458 1166130008657 UPF0126 domain; Region: UPF0126; pfam03458 1166130008658 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 1166130008659 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 1166130008660 nucleotide binding pocket [chemical binding]; other site 1166130008661 K-X-D-G motif; other site 1166130008662 catalytic site [active] 1166130008663 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1166130008664 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1166130008665 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1166130008666 catalytic site [active] 1166130008667 G-X2-G-X-G-K; other site 1166130008668 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1166130008669 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 1166130008670 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1166130008671 Zn2+ binding site [ion binding]; other site 1166130008672 Mg2+ binding site [ion binding]; other site 1166130008673 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1166130008674 synthetase active site [active] 1166130008675 NTP binding site [chemical binding]; other site 1166130008676 metal binding site [ion binding]; metal-binding site 1166130008677 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1166130008678 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1166130008679 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 1166130008680 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1166130008681 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 1166130008682 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1166130008683 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1166130008684 generic binding surface II; other site 1166130008685 ssDNA binding site; other site 1166130008686 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1166130008687 ATP binding site [chemical binding]; other site 1166130008688 putative Mg++ binding site [ion binding]; other site 1166130008689 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1166130008690 nucleotide binding region [chemical binding]; other site 1166130008691 ATP-binding site [chemical binding]; other site 1166130008692 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1166130008693 AsmA family; Region: AsmA; pfam05170 1166130008694 HicB family; Region: HicB; pfam05534 1166130008695 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 1166130008696 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1166130008697 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1166130008698 FMN binding site [chemical binding]; other site 1166130008699 active site 1166130008700 substrate binding site [chemical binding]; other site 1166130008701 catalytic residue [active] 1166130008702 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1166130008703 DNA binding residues [nucleotide binding] 1166130008704 dimerization interface [polypeptide binding]; other site 1166130008705 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 1166130008706 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1166130008707 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1166130008708 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1166130008709 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1166130008710 inhibitor site; inhibition site 1166130008711 active site 1166130008712 dimer interface [polypeptide binding]; other site 1166130008713 catalytic residue [active] 1166130008714 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1166130008715 B3/4 domain; Region: B3_4; pfam03483 1166130008716 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1166130008717 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1166130008718 non-specific DNA binding site [nucleotide binding]; other site 1166130008719 salt bridge; other site 1166130008720 sequence-specific DNA binding site [nucleotide binding]; other site 1166130008721 Cupin domain; Region: Cupin_2; pfam07883 1166130008722 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130008723 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1166130008724 putative substrate translocation pore; other site 1166130008725 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1166130008726 Predicted transcriptional regulator [Transcription]; Region: COG2378 1166130008727 WYL domain; Region: WYL; pfam13280 1166130008728 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1166130008729 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1166130008730 active site 1166130008731 catalytic tetrad [active] 1166130008732 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166130008733 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130008734 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1166130008735 putative effector binding pocket; other site 1166130008736 dimerization interface [polypeptide binding]; other site 1166130008737 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1166130008738 FMN binding site [chemical binding]; other site 1166130008739 dimer interface [polypeptide binding]; other site 1166130008740 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1166130008741 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1166130008742 NAD binding site [chemical binding]; other site 1166130008743 catalytic Zn binding site [ion binding]; other site 1166130008744 structural Zn binding site [ion binding]; other site 1166130008745 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1166130008746 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1166130008747 Walker A/P-loop; other site 1166130008748 ATP binding site [chemical binding]; other site 1166130008749 Q-loop/lid; other site 1166130008750 ABC transporter signature motif; other site 1166130008751 Walker B; other site 1166130008752 D-loop; other site 1166130008753 H-loop/switch region; other site 1166130008754 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1166130008755 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1166130008756 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1166130008757 Walker A/P-loop; other site 1166130008758 ATP binding site [chemical binding]; other site 1166130008759 Q-loop/lid; other site 1166130008760 ABC transporter signature motif; other site 1166130008761 Walker B; other site 1166130008762 D-loop; other site 1166130008763 H-loop/switch region; other site 1166130008764 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1166130008765 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1166130008766 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1166130008767 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130008768 dimer interface [polypeptide binding]; other site 1166130008769 conserved gate region; other site 1166130008770 putative PBP binding loops; other site 1166130008771 ABC-ATPase subunit interface; other site 1166130008772 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1166130008773 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130008774 dimer interface [polypeptide binding]; other site 1166130008775 conserved gate region; other site 1166130008776 putative PBP binding loops; other site 1166130008777 ABC-ATPase subunit interface; other site 1166130008778 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1166130008779 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1166130008780 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1166130008781 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1166130008782 DNA binding site [nucleotide binding] 1166130008783 domain linker motif; other site 1166130008784 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1166130008785 ligand binding site [chemical binding]; other site 1166130008786 dimerization interface [polypeptide binding]; other site 1166130008787 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1166130008788 active site 1166130008789 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1166130008790 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1166130008791 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1166130008792 beta-galactosidase; Region: BGL; TIGR03356 1166130008793 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1166130008794 methionine cluster; other site 1166130008795 active site 1166130008796 phosphorylation site [posttranslational modification] 1166130008797 metal binding site [ion binding]; metal-binding site 1166130008798 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1166130008799 EamA-like transporter family; Region: EamA; pfam00892 1166130008800 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1166130008801 EamA-like transporter family; Region: EamA; pfam00892 1166130008802 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 1166130008803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130008804 putative substrate translocation pore; other site 1166130008805 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 1166130008806 putative hydrophobic ligand binding site [chemical binding]; other site 1166130008807 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 1166130008808 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166130008809 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130008810 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1166130008811 dimerization interface [polypeptide binding]; other site 1166130008812 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 1166130008813 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1166130008814 putative valine binding site [chemical binding]; other site 1166130008815 dimer interface [polypeptide binding]; other site 1166130008816 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 1166130008817 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1166130008818 PYR/PP interface [polypeptide binding]; other site 1166130008819 dimer interface [polypeptide binding]; other site 1166130008820 TPP binding site [chemical binding]; other site 1166130008821 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1166130008822 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1166130008823 TPP-binding site [chemical binding]; other site 1166130008824 dimer interface [polypeptide binding]; other site 1166130008825 FlhB HrpN YscU SpaS Family; Region: Bac_export_2; pfam01312 1166130008826 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1166130008827 Bacterial export proteins, family 1; Region: Bac_export_1; pfam01311 1166130008828 Bacterial export proteins, family 3; Region: Bac_export_3; pfam01313 1166130008829 type III secretion system protein YscR; Provisional; Region: PRK12797 1166130008830 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 1166130008831 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1166130008832 type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546 1166130008833 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1166130008834 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1166130008835 Walker A motif; other site 1166130008836 ATP binding site [chemical binding]; other site 1166130008837 Walker B motif; other site 1166130008838 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 1166130008839 phosphopeptide binding site; other site 1166130008840 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 1166130008841 FHIPEP family; Region: FHIPEP; pfam00771 1166130008842 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1166130008843 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1166130008844 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1166130008845 DNA binding residues [nucleotide binding] 1166130008846 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1166130008847 HrpF protein; Region: HrpF; pfam06266 1166130008848 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 1166130008849 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1166130008850 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1166130008851 HrpE/YscL/FliH and V-type ATPase subunit E; Region: HrpE; pfam06188 1166130008852 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1166130008853 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1166130008854 Type III secretion needle MxiH like; Region: MxiH; pfam09392 1166130008855 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 1166130008856 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1166130008857 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 1166130008858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130008859 putative substrate translocation pore; other site 1166130008860 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 1166130008861 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1166130008862 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1166130008863 catalytic residue [active] 1166130008864 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1166130008865 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1166130008866 Domain of unknown function (DUF202); Region: DUF202; pfam02656 1166130008867 Predicted membrane protein [Function unknown]; Region: COG2149 1166130008868 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1166130008869 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 1166130008870 NAD binding site [chemical binding]; other site 1166130008871 sugar binding site [chemical binding]; other site 1166130008872 divalent metal binding site [ion binding]; other site 1166130008873 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1166130008874 dimer interface [polypeptide binding]; other site 1166130008875 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1166130008876 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1166130008877 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1166130008878 active site turn [active] 1166130008879 phosphorylation site [posttranslational modification] 1166130008880 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1166130008881 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166130008882 DNA-binding site [nucleotide binding]; DNA binding site 1166130008883 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1166130008884 putative transporter; Validated; Region: PRK03818 1166130008885 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1166130008886 TrkA-C domain; Region: TrkA_C; pfam02080 1166130008887 TrkA-C domain; Region: TrkA_C; pfam02080 1166130008888 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1166130008889 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 1166130008890 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130008891 putative substrate translocation pore; other site 1166130008892 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1166130008893 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1166130008894 putative dimer interface [polypeptide binding]; other site 1166130008895 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1166130008896 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1166130008897 putative dimer interface [polypeptide binding]; other site 1166130008898 hypothetical protein; Provisional; Region: PRK11616 1166130008899 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 1166130008900 putative oxidoreductase; Provisional; Region: PRK11445 1166130008901 sugar phosphate phosphatase; Provisional; Region: PRK10513 1166130008902 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1166130008903 active site 1166130008904 motif I; other site 1166130008905 motif II; other site 1166130008906 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1166130008907 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1166130008908 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166130008909 Mg2+ binding site [ion binding]; other site 1166130008910 G-X-G motif; other site 1166130008911 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1166130008912 anchoring element; other site 1166130008913 dimer interface [polypeptide binding]; other site 1166130008914 ATP binding site [chemical binding]; other site 1166130008915 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1166130008916 active site 1166130008917 putative metal-binding site [ion binding]; other site 1166130008918 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1166130008919 recF protein; Region: recf; TIGR00611 1166130008920 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166130008921 Walker A/P-loop; other site 1166130008922 ATP binding site [chemical binding]; other site 1166130008923 Q-loop/lid; other site 1166130008924 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166130008925 ABC transporter signature motif; other site 1166130008926 Walker B; other site 1166130008927 D-loop; other site 1166130008928 H-loop/switch region; other site 1166130008929 DNA polymerase III subunit beta; Validated; Region: PRK05643 1166130008930 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1166130008931 putative DNA binding surface [nucleotide binding]; other site 1166130008932 dimer interface [polypeptide binding]; other site 1166130008933 beta-clamp/clamp loader binding surface; other site 1166130008934 beta-clamp/translesion DNA polymerase binding surface; other site 1166130008935 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1166130008936 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1166130008937 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166130008938 Walker A motif; other site 1166130008939 ATP binding site [chemical binding]; other site 1166130008940 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1166130008941 Walker B motif; other site 1166130008942 arginine finger; other site 1166130008943 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1166130008944 DnaA box-binding interface [nucleotide binding]; other site 1166130008945 ribonuclease P; Reviewed; Region: rnpA; PRK01732 1166130008946 membrane protein insertase; Provisional; Region: PRK01318 1166130008947 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1166130008948 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1166130008949 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1166130008950 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1166130008951 G1 box; other site 1166130008952 GTP/Mg2+ binding site [chemical binding]; other site 1166130008953 Switch I region; other site 1166130008954 G2 box; other site 1166130008955 Switch II region; other site 1166130008956 G3 box; other site 1166130008957 G4 box; other site 1166130008958 G5 box; other site 1166130008959 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1166130008960 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1166130008961 Predicted flavoprotein [General function prediction only]; Region: COG0431 1166130008962 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1166130008963 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1166130008964 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 1166130008965 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1166130008966 motif II; other site 1166130008967 Uncharacterized protein family (UPF0167); Region: UPF0167; pfam03691 1166130008968 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1166130008969 transcriptional regulator PhoU; Provisional; Region: PRK11115 1166130008970 PhoU domain; Region: PhoU; pfam01895 1166130008971 PhoU domain; Region: PhoU; pfam01895 1166130008972 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 1166130008973 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1166130008974 Walker A/P-loop; other site 1166130008975 ATP binding site [chemical binding]; other site 1166130008976 Q-loop/lid; other site 1166130008977 ABC transporter signature motif; other site 1166130008978 Walker B; other site 1166130008979 D-loop; other site 1166130008980 H-loop/switch region; other site 1166130008981 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 1166130008982 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130008983 dimer interface [polypeptide binding]; other site 1166130008984 conserved gate region; other site 1166130008985 putative PBP binding loops; other site 1166130008986 ABC-ATPase subunit interface; other site 1166130008987 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 1166130008988 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130008989 dimer interface [polypeptide binding]; other site 1166130008990 conserved gate region; other site 1166130008991 putative PBP binding loops; other site 1166130008992 ABC-ATPase subunit interface; other site 1166130008993 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166130008994 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1166130008995 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1166130008996 glutaminase active site [active] 1166130008997 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1166130008998 dimer interface [polypeptide binding]; other site 1166130008999 active site 1166130009000 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1166130009001 dimer interface [polypeptide binding]; other site 1166130009002 active site 1166130009003 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 1166130009004 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1166130009005 Substrate binding site; other site 1166130009006 Mg++ binding site; other site 1166130009007 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1166130009008 active site 1166130009009 substrate binding site [chemical binding]; other site 1166130009010 CoA binding site [chemical binding]; other site 1166130009011 Right handed beta helix region; Region: Beta_helix; pfam13229 1166130009012 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1166130009013 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1166130009014 gamma subunit interface [polypeptide binding]; other site 1166130009015 epsilon subunit interface [polypeptide binding]; other site 1166130009016 LBP interface [polypeptide binding]; other site 1166130009017 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1166130009018 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1166130009019 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1166130009020 alpha subunit interaction interface [polypeptide binding]; other site 1166130009021 Walker A motif; other site 1166130009022 ATP binding site [chemical binding]; other site 1166130009023 Walker B motif; other site 1166130009024 inhibitor binding site; inhibition site 1166130009025 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1166130009026 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1166130009027 core domain interface [polypeptide binding]; other site 1166130009028 delta subunit interface [polypeptide binding]; other site 1166130009029 epsilon subunit interface [polypeptide binding]; other site 1166130009030 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1166130009031 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1166130009032 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1166130009033 beta subunit interaction interface [polypeptide binding]; other site 1166130009034 Walker A motif; other site 1166130009035 ATP binding site [chemical binding]; other site 1166130009036 Walker B motif; other site 1166130009037 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1166130009038 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1166130009039 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1166130009040 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1166130009041 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1166130009042 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1166130009043 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1166130009044 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1166130009045 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 1166130009046 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1166130009047 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166130009048 S-adenosylmethionine binding site [chemical binding]; other site 1166130009049 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1166130009050 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1166130009051 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1166130009052 FMN-binding protein MioC; Provisional; Region: PRK09004 1166130009053 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 1166130009054 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1166130009055 putative DNA binding site [nucleotide binding]; other site 1166130009056 putative Zn2+ binding site [ion binding]; other site 1166130009057 AsnC family; Region: AsnC_trans_reg; pfam01037 1166130009058 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 1166130009059 dimer interface [polypeptide binding]; other site 1166130009060 active site 1166130009061 hypothetical protein; Provisional; Region: yieM; PRK10997 1166130009062 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 1166130009063 metal ion-dependent adhesion site (MIDAS); other site 1166130009064 regulatory ATPase RavA; Provisional; Region: PRK13531 1166130009065 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166130009066 Walker A motif; other site 1166130009067 ATP binding site [chemical binding]; other site 1166130009068 Walker B motif; other site 1166130009069 arginine finger; other site 1166130009070 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 1166130009071 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 1166130009072 potassium uptake protein; Region: kup; TIGR00794 1166130009073 D-ribose pyranase; Provisional; Region: PRK11797 1166130009074 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 1166130009075 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1166130009076 Walker A/P-loop; other site 1166130009077 ATP binding site [chemical binding]; other site 1166130009078 Q-loop/lid; other site 1166130009079 ABC transporter signature motif; other site 1166130009080 Walker B; other site 1166130009081 D-loop; other site 1166130009082 H-loop/switch region; other site 1166130009083 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1166130009084 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1166130009085 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1166130009086 TM-ABC transporter signature motif; other site 1166130009087 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1166130009088 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1166130009089 ligand binding site [chemical binding]; other site 1166130009090 dimerization interface [polypeptide binding]; other site 1166130009091 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1166130009092 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1166130009093 substrate binding site [chemical binding]; other site 1166130009094 dimer interface [polypeptide binding]; other site 1166130009095 ATP binding site [chemical binding]; other site 1166130009096 transcriptional repressor RbsR; Provisional; Region: PRK10423 1166130009097 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1166130009098 DNA binding site [nucleotide binding] 1166130009099 domain linker motif; other site 1166130009100 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1166130009101 dimerization interface [polypeptide binding]; other site 1166130009102 ligand binding site [chemical binding]; other site 1166130009103 putative transporter; Provisional; Region: PRK10504 1166130009104 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130009105 putative substrate translocation pore; other site 1166130009106 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130009107 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1166130009108 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166130009109 DNA-binding site [nucleotide binding]; DNA binding site 1166130009110 FCD domain; Region: FCD; pfam07729 1166130009111 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1166130009112 Walker A motif; other site 1166130009113 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1166130009114 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1166130009115 GTP binding site; other site 1166130009116 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 1166130009117 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1166130009118 serine/threonine protein kinase; Provisional; Region: PRK11768 1166130009119 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1166130009120 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1166130009121 catalytic residues [active] 1166130009122 hinge region; other site 1166130009123 alpha helical domain; other site 1166130009124 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1166130009125 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 1166130009126 putative acyl-acceptor binding pocket; other site 1166130009127 DNA polymerase I; Provisional; Region: PRK05755 1166130009128 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1166130009129 active site 1166130009130 metal binding site 1 [ion binding]; metal-binding site 1166130009131 putative 5' ssDNA interaction site; other site 1166130009132 metal binding site 3; metal-binding site 1166130009133 metal binding site 2 [ion binding]; metal-binding site 1166130009134 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1166130009135 putative DNA binding site [nucleotide binding]; other site 1166130009136 putative metal binding site [ion binding]; other site 1166130009137 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1166130009138 active site 1166130009139 catalytic site [active] 1166130009140 substrate binding site [chemical binding]; other site 1166130009141 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1166130009142 active site 1166130009143 DNA binding site [nucleotide binding] 1166130009144 catalytic site [active] 1166130009145 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1166130009146 G1 box; other site 1166130009147 GTP/Mg2+ binding site [chemical binding]; other site 1166130009148 Switch I region; other site 1166130009149 G2 box; other site 1166130009150 G3 box; other site 1166130009151 Switch II region; other site 1166130009152 G4 box; other site 1166130009153 G5 box; other site 1166130009154 Der GTPase activator; Provisional; Region: PRK05244 1166130009155 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1166130009156 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1166130009157 FeS/SAM binding site; other site 1166130009158 HemN C-terminal domain; Region: HemN_C; pfam06969 1166130009159 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 1166130009160 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130009161 active site 1166130009162 phosphorylation site [posttranslational modification] 1166130009163 intermolecular recognition site; other site 1166130009164 dimerization interface [polypeptide binding]; other site 1166130009165 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166130009166 Walker A motif; other site 1166130009167 ATP binding site [chemical binding]; other site 1166130009168 Walker B motif; other site 1166130009169 arginine finger; other site 1166130009170 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1166130009171 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 1166130009172 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1166130009173 putative active site [active] 1166130009174 heme pocket [chemical binding]; other site 1166130009175 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1166130009176 dimer interface [polypeptide binding]; other site 1166130009177 phosphorylation site [posttranslational modification] 1166130009178 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166130009179 ATP binding site [chemical binding]; other site 1166130009180 Mg2+ binding site [ion binding]; other site 1166130009181 G-X-G motif; other site 1166130009182 glutamine synthetase; Provisional; Region: glnA; PRK09469 1166130009183 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1166130009184 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1166130009185 GTP-binding protein; Provisional; Region: PRK10218 1166130009186 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1166130009187 G1 box; other site 1166130009188 putative GEF interaction site [polypeptide binding]; other site 1166130009189 GTP/Mg2+ binding site [chemical binding]; other site 1166130009190 Switch I region; other site 1166130009191 G2 box; other site 1166130009192 G3 box; other site 1166130009193 Switch II region; other site 1166130009194 G4 box; other site 1166130009195 G5 box; other site 1166130009196 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1166130009197 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1166130009198 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1166130009199 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1166130009200 motif II; other site 1166130009201 hypothetical protein; Reviewed; Region: PRK01637 1166130009202 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1166130009203 putative active site [active] 1166130009204 dimerization interface [polypeptide binding]; other site 1166130009205 putative tRNAtyr binding site [nucleotide binding]; other site 1166130009206 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166130009207 Coenzyme A binding pocket [chemical binding]; other site 1166130009208 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 1166130009209 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1166130009210 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1166130009211 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1166130009212 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 1166130009213 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 1166130009214 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 1166130009215 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1166130009216 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1166130009217 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1166130009218 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1166130009219 molybdopterin cofactor binding site; other site 1166130009220 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1166130009221 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1166130009222 molybdopterin cofactor binding site; other site 1166130009223 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1166130009224 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1166130009225 Flagellar protein FlhE; Region: FlhE; pfam06366 1166130009226 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1166130009227 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1166130009228 Walker A/P-loop; other site 1166130009229 ATP binding site [chemical binding]; other site 1166130009230 Q-loop/lid; other site 1166130009231 ABC transporter signature motif; other site 1166130009232 Walker B; other site 1166130009233 D-loop; other site 1166130009234 H-loop/switch region; other site 1166130009235 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1166130009236 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1166130009237 FtsX-like permease family; Region: FtsX; pfam02687 1166130009238 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1166130009239 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1166130009240 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1166130009241 HlyD family secretion protein; Region: HlyD_3; pfam13437 1166130009242 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1166130009243 AzlC protein; Region: AzlC; cl00570 1166130009244 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1166130009245 non-specific DNA binding site [nucleotide binding]; other site 1166130009246 salt bridge; other site 1166130009247 sequence-specific DNA binding site [nucleotide binding]; other site 1166130009248 Cupin domain; Region: Cupin_2; cl17218 1166130009249 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1166130009250 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1166130009251 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1166130009252 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1166130009253 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1166130009254 PapC N-terminal domain; Region: PapC_N; pfam13954 1166130009255 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1166130009256 PapC C-terminal domain; Region: PapC_C; pfam13953 1166130009257 Fimbrial protein; Region: Fimbrial; cl01416 1166130009258 fimbrial assembly chaperone SthB; Provisional; Region: PRK15295 1166130009259 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1166130009260 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1166130009261 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 1166130009262 lactaldehyde reductase; Region: lactal_redase; TIGR02638 1166130009263 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1166130009264 dimer interface [polypeptide binding]; other site 1166130009265 active site 1166130009266 metal binding site [ion binding]; metal-binding site 1166130009267 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1166130009268 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1166130009269 TM-ABC transporter signature motif; other site 1166130009270 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1166130009271 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1166130009272 TM-ABC transporter signature motif; other site 1166130009273 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1166130009274 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1166130009275 Walker A/P-loop; other site 1166130009276 ATP binding site [chemical binding]; other site 1166130009277 Q-loop/lid; other site 1166130009278 ABC transporter signature motif; other site 1166130009279 Walker B; other site 1166130009280 D-loop; other site 1166130009281 H-loop/switch region; other site 1166130009282 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1166130009283 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 1166130009284 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 1166130009285 ligand binding site [chemical binding]; other site 1166130009286 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1166130009287 intersubunit interface [polypeptide binding]; other site 1166130009288 active site 1166130009289 Zn2+ binding site [ion binding]; other site 1166130009290 L-rhamnose isomerase; Provisional; Region: PRK01076 1166130009291 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1166130009292 N- and C-terminal domain interface [polypeptide binding]; other site 1166130009293 active site 1166130009294 putative catalytic site [active] 1166130009295 metal binding site [ion binding]; metal-binding site 1166130009296 ATP binding site [chemical binding]; other site 1166130009297 rhamnulokinase; Provisional; Region: rhaB; PRK10640 1166130009298 carbohydrate binding site [chemical binding]; other site 1166130009299 transcriptional activator RhaS; Provisional; Region: PRK13503 1166130009300 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1166130009301 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130009302 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130009303 transcriptional activator RhaR; Provisional; Region: PRK13502 1166130009304 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1166130009305 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130009306 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 1166130009307 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 1166130009308 superoxide dismutase; Provisional; Region: PRK10925 1166130009309 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1166130009310 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1166130009311 2-keto-3-deoxygluconate transporter; Region: kdgT; TIGR00793 1166130009312 N-acetylneuraminate lyase; Region: nanA; TIGR00683 1166130009313 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1166130009314 inhibitor site; inhibition site 1166130009315 active site 1166130009316 dimer interface [polypeptide binding]; other site 1166130009317 catalytic residue [active] 1166130009318 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 1166130009319 MOSC domain; Region: MOSC; pfam03473 1166130009320 3-alpha domain; Region: 3-alpha; pfam03475 1166130009321 two-component sensor protein; Provisional; Region: cpxA; PRK09470 1166130009322 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166130009323 dimerization interface [polypeptide binding]; other site 1166130009324 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1166130009325 dimer interface [polypeptide binding]; other site 1166130009326 phosphorylation site [posttranslational modification] 1166130009327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166130009328 ATP binding site [chemical binding]; other site 1166130009329 Mg2+ binding site [ion binding]; other site 1166130009330 G-X-G motif; other site 1166130009331 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 1166130009332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130009333 intermolecular recognition site; other site 1166130009334 active site 1166130009335 dimerization interface [polypeptide binding]; other site 1166130009336 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1166130009337 DNA binding site [nucleotide binding] 1166130009338 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1166130009339 dimer interface [polypeptide binding]; other site 1166130009340 integrase; Provisional; Region: int; PHA02601 1166130009341 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1166130009342 active site 1166130009343 DNA binding site [nucleotide binding] 1166130009344 Int/Topo IB signature motif; other site 1166130009345 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1166130009346 non-specific DNA binding site [nucleotide binding]; other site 1166130009347 salt bridge; other site 1166130009348 sequence-specific DNA binding site [nucleotide binding]; other site 1166130009349 Regulatory phage protein cox; Region: Phage_Cox; pfam10743 1166130009350 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 1166130009351 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 1166130009352 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 1166130009353 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 1166130009354 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 1166130009355 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 1166130009356 Protein of unknown function (DUF3121); Region: DUF3121; cl11879 1166130009357 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 1166130009358 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1166130009359 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1166130009360 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1166130009361 active site 1166130009362 ADP/pyrophosphate binding site [chemical binding]; other site 1166130009363 dimerization interface [polypeptide binding]; other site 1166130009364 allosteric effector site; other site 1166130009365 fructose-1,6-bisphosphate binding site; other site 1166130009366 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1166130009367 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166130009368 substrate binding pocket [chemical binding]; other site 1166130009369 membrane-bound complex binding site; other site 1166130009370 hinge residues; other site 1166130009371 CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471 1166130009372 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1166130009373 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1166130009374 transmembrane helices; other site 1166130009375 triosephosphate isomerase; Provisional; Region: PRK14567 1166130009376 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1166130009377 substrate binding site [chemical binding]; other site 1166130009378 dimer interface [polypeptide binding]; other site 1166130009379 catalytic triad [active] 1166130009380 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 1166130009381 Predicted membrane protein [Function unknown]; Region: COG3152 1166130009382 ferredoxin-NADP reductase; Provisional; Region: PRK10926 1166130009383 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1166130009384 FAD binding pocket [chemical binding]; other site 1166130009385 FAD binding motif [chemical binding]; other site 1166130009386 phosphate binding motif [ion binding]; other site 1166130009387 beta-alpha-beta structure motif; other site 1166130009388 NAD binding pocket [chemical binding]; other site 1166130009389 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1166130009390 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1166130009391 putative active site [active] 1166130009392 glycerol kinase; Provisional; Region: glpK; PRK00047 1166130009393 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1166130009394 N- and C-terminal domain interface [polypeptide binding]; other site 1166130009395 active site 1166130009396 MgATP binding site [chemical binding]; other site 1166130009397 catalytic site [active] 1166130009398 metal binding site [ion binding]; metal-binding site 1166130009399 glycerol binding site [chemical binding]; other site 1166130009400 homotetramer interface [polypeptide binding]; other site 1166130009401 homodimer interface [polypeptide binding]; other site 1166130009402 FBP binding site [chemical binding]; other site 1166130009403 protein IIAGlc interface [polypeptide binding]; other site 1166130009404 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1166130009405 amphipathic channel; other site 1166130009406 Asn-Pro-Ala signature motifs; other site 1166130009407 septal ring assembly protein ZapB; Provisional; Region: PRK15422 1166130009408 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1166130009409 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 1166130009410 UbiA prenyltransferase family; Region: UbiA; pfam01040 1166130009411 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1166130009412 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166130009413 Walker A motif; other site 1166130009414 ATP binding site [chemical binding]; other site 1166130009415 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1166130009416 Walker B motif; other site 1166130009417 arginine finger; other site 1166130009418 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1166130009419 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1166130009420 active site 1166130009421 HslU subunit interaction site [polypeptide binding]; other site 1166130009422 cell division protein FtsN; Provisional; Region: PRK12757 1166130009423 Sporulation related domain; Region: SPOR; cl10051 1166130009424 Sporulation related domain; Region: SPOR; cl10051 1166130009425 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1166130009426 DNA binding site [nucleotide binding] 1166130009427 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 1166130009428 domain linker motif; other site 1166130009429 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 1166130009430 dimerization interface [polypeptide binding]; other site 1166130009431 ligand binding site [chemical binding]; other site 1166130009432 primosome assembly protein PriA; Validated; Region: PRK05580 1166130009433 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1166130009434 ATP binding site [chemical binding]; other site 1166130009435 putative Mg++ binding site [ion binding]; other site 1166130009436 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1166130009437 ATP-binding site [chemical binding]; other site 1166130009438 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1166130009439 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 1166130009440 dimerization interface [polypeptide binding]; other site 1166130009441 DNA binding site [nucleotide binding] 1166130009442 corepressor binding sites; other site 1166130009443 cystathionine gamma-synthase; Provisional; Region: PRK08045 1166130009444 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1166130009445 homodimer interface [polypeptide binding]; other site 1166130009446 substrate-cofactor binding pocket; other site 1166130009447 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130009448 catalytic residue [active] 1166130009449 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 1166130009450 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1166130009451 putative catalytic residues [active] 1166130009452 putative nucleotide binding site [chemical binding]; other site 1166130009453 putative aspartate binding site [chemical binding]; other site 1166130009454 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 1166130009455 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1166130009456 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1166130009457 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1166130009458 FAD binding site [chemical binding]; other site 1166130009459 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1166130009460 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1166130009461 dimer interface [polypeptide binding]; other site 1166130009462 active site 1166130009463 metal binding site [ion binding]; metal-binding site 1166130009464 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1166130009465 active site 1166130009466 intersubunit interactions; other site 1166130009467 catalytic residue [active] 1166130009468 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1166130009469 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130009470 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1166130009471 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1166130009472 acetylornithine deacetylase; Provisional; Region: PRK05111 1166130009473 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1166130009474 metal binding site [ion binding]; metal-binding site 1166130009475 putative dimer interface [polypeptide binding]; other site 1166130009476 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1166130009477 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1166130009478 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 1166130009479 nucleotide binding site [chemical binding]; other site 1166130009480 N-acetyl-L-glutamate binding site [chemical binding]; other site 1166130009481 argininosuccinate lyase; Provisional; Region: PRK04833 1166130009482 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1166130009483 active sites [active] 1166130009484 tetramer interface [polypeptide binding]; other site 1166130009485 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1166130009486 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130009487 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1166130009488 dimerization interface [polypeptide binding]; other site 1166130009489 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1166130009490 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1166130009491 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1166130009492 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1166130009493 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1166130009494 hypothetical protein; Provisional; Region: PRK11056 1166130009495 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 1166130009496 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166130009497 S-adenosylmethionine binding site [chemical binding]; other site 1166130009498 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 1166130009499 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1166130009500 N-terminal plug; other site 1166130009501 ligand-binding site [chemical binding]; other site 1166130009502 glutamate racemase; Provisional; Region: PRK00865 1166130009503 transcriptional regulator HdfR; Provisional; Region: PRK03601 1166130009504 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1166130009505 transcriptional regulator HdfR; Provisional; Region: PRK03601 1166130009506 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130009507 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1166130009508 dimerization interface [polypeptide binding]; other site 1166130009509 hypothetical protein; Provisional; Region: PRK11027 1166130009510 putative ATP-dependent protease; Provisional; Region: PRK09862 1166130009511 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1166130009512 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166130009513 Walker A motif; other site 1166130009514 ATP binding site [chemical binding]; other site 1166130009515 Walker B motif; other site 1166130009516 arginine finger; other site 1166130009517 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1166130009518 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 1166130009519 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1166130009520 PYR/PP interface [polypeptide binding]; other site 1166130009521 dimer interface [polypeptide binding]; other site 1166130009522 TPP binding site [chemical binding]; other site 1166130009523 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1166130009524 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1166130009525 TPP-binding site [chemical binding]; other site 1166130009526 dimer interface [polypeptide binding]; other site 1166130009527 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 1166130009528 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1166130009529 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1166130009530 homodimer interface [polypeptide binding]; other site 1166130009531 substrate-cofactor binding pocket; other site 1166130009532 catalytic residue [active] 1166130009533 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1166130009534 threonine dehydratase; Reviewed; Region: PRK09224 1166130009535 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1166130009536 tetramer interface [polypeptide binding]; other site 1166130009537 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130009538 catalytic residue [active] 1166130009539 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1166130009540 putative Ile/Val binding site [chemical binding]; other site 1166130009541 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1166130009542 putative Ile/Val binding site [chemical binding]; other site 1166130009543 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130009544 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 1166130009545 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 1166130009546 putative dimerization interface [polypeptide binding]; other site 1166130009547 ketol-acid reductoisomerase; Validated; Region: PRK05225 1166130009548 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1166130009549 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1166130009550 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1166130009551 Predicted transcriptional regulator [Transcription]; Region: COG1959 1166130009552 Transcriptional regulator; Region: Rrf2; pfam02082 1166130009553 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 1166130009554 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1166130009555 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 1166130009556 Part of AAA domain; Region: AAA_19; pfam13245 1166130009557 Family description; Region: UvrD_C_2; pfam13538 1166130009558 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 1166130009559 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1166130009560 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 1166130009561 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1166130009562 ATP binding site [chemical binding]; other site 1166130009563 Mg++ binding site [ion binding]; other site 1166130009564 motif III; other site 1166130009565 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1166130009566 nucleotide binding region [chemical binding]; other site 1166130009567 ATP-binding site [chemical binding]; other site 1166130009568 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1166130009569 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1166130009570 catalytic residues [active] 1166130009571 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1166130009572 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1166130009573 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1166130009574 RNA binding site [nucleotide binding]; other site 1166130009575 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1166130009576 multimer interface [polypeptide binding]; other site 1166130009577 Walker A motif; other site 1166130009578 ATP binding site [chemical binding]; other site 1166130009579 Walker B motif; other site 1166130009580 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 1166130009581 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1166130009582 Mg++ binding site [ion binding]; other site 1166130009583 putative catalytic motif [active] 1166130009584 substrate binding site [chemical binding]; other site 1166130009585 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 1166130009586 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1166130009587 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1166130009588 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1166130009589 homodimer interface [polypeptide binding]; other site 1166130009590 active site 1166130009591 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 1166130009592 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1166130009593 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1166130009594 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1166130009595 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166130009596 Coenzyme A binding pocket [chemical binding]; other site 1166130009597 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1166130009598 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1166130009599 inhibitor-cofactor binding pocket; inhibition site 1166130009600 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130009601 catalytic residue [active] 1166130009602 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1166130009603 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 1166130009604 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 1166130009605 putative common antigen polymerase; Provisional; Region: PRK02975 1166130009606 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1166130009607 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1166130009608 putative transport protein YifK; Provisional; Region: PRK10746 1166130009609 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 1166130009610 HemY protein N-terminus; Region: HemY_N; pfam07219 1166130009611 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1166130009612 HemX; Region: HemX; pfam04375 1166130009613 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1166130009614 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1166130009615 active site 1166130009616 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1166130009617 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1166130009618 domain interfaces; other site 1166130009619 active site 1166130009620 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 1166130009621 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 1166130009622 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 1166130009623 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 1166130009624 putative iron binding site [ion binding]; other site 1166130009625 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 1166130009626 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1166130009627 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1166130009628 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1166130009629 hypothetical protein; Provisional; Region: PRK10963 1166130009630 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 1166130009631 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1166130009632 active site 1166130009633 DNA binding site [nucleotide binding] 1166130009634 Int/Topo IB signature motif; other site 1166130009635 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 1166130009636 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1166130009637 motif II; other site 1166130009638 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1166130009639 Part of AAA domain; Region: AAA_19; pfam13245 1166130009640 Family description; Region: UvrD_C_2; pfam13538 1166130009641 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1166130009642 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 1166130009643 Cl binding site [ion binding]; other site 1166130009644 oligomer interface [polypeptide binding]; other site 1166130009645 hypothetical protein; Provisional; Region: PRK11371 1166130009646 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 1166130009647 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1166130009648 CoenzymeA binding site [chemical binding]; other site 1166130009649 subunit interaction site [polypeptide binding]; other site 1166130009650 PHB binding site; other site 1166130009651 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 1166130009652 dimerization interface [polypeptide binding]; other site 1166130009653 substrate binding site [chemical binding]; other site 1166130009654 active site 1166130009655 calcium binding site [ion binding]; other site 1166130009656 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 1166130009657 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1166130009658 ATP binding site [chemical binding]; other site 1166130009659 putative Mg++ binding site [ion binding]; other site 1166130009660 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1166130009661 nucleotide binding region [chemical binding]; other site 1166130009662 ATP-binding site [chemical binding]; other site 1166130009663 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1166130009664 HRDC domain; Region: HRDC; pfam00570 1166130009665 threonine efflux system; Provisional; Region: PRK10229 1166130009666 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 1166130009667 lysophospholipase L2; Provisional; Region: PRK10749 1166130009668 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1166130009669 putative hydrolase; Provisional; Region: PRK10976 1166130009670 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1166130009671 active site 1166130009672 motif I; other site 1166130009673 motif II; other site 1166130009674 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1166130009675 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1166130009676 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 1166130009677 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130009678 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 1166130009679 putative dimerization interface [polypeptide binding]; other site 1166130009680 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1166130009681 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1166130009682 THF binding site; other site 1166130009683 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1166130009684 substrate binding site [chemical binding]; other site 1166130009685 THF binding site; other site 1166130009686 zinc-binding site [ion binding]; other site 1166130009687 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1166130009688 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1166130009689 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1166130009690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130009691 dimer interface [polypeptide binding]; other site 1166130009692 conserved gate region; other site 1166130009693 putative PBP binding loops; other site 1166130009694 ABC-ATPase subunit interface; other site 1166130009695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1166130009696 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1166130009697 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166130009698 Walker A/P-loop; other site 1166130009699 ATP binding site [chemical binding]; other site 1166130009700 Q-loop/lid; other site 1166130009701 ABC transporter signature motif; other site 1166130009702 Walker B; other site 1166130009703 D-loop; other site 1166130009704 H-loop/switch region; other site 1166130009705 TOBE domain; Region: TOBE_2; pfam08402 1166130009706 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1166130009707 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1166130009708 uridine phosphorylase; Provisional; Region: PRK11178 1166130009709 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 1166130009710 DNA recombination protein RmuC; Provisional; Region: PRK10361 1166130009711 RmuC family; Region: RmuC; pfam02646 1166130009712 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1166130009713 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166130009714 S-adenosylmethionine binding site [chemical binding]; other site 1166130009715 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 1166130009716 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 1166130009717 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1166130009718 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 1166130009719 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1166130009720 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1166130009721 sec-independent translocase; Provisional; Region: PRK01770 1166130009722 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 1166130009723 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1166130009724 active site 1166130009725 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 1166130009726 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 1166130009727 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 1166130009728 FMN reductase; Validated; Region: fre; PRK08051 1166130009729 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1166130009730 FAD binding pocket [chemical binding]; other site 1166130009731 FAD binding motif [chemical binding]; other site 1166130009732 phosphate binding motif [ion binding]; other site 1166130009733 beta-alpha-beta structure motif; other site 1166130009734 NAD binding pocket [chemical binding]; other site 1166130009735 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 1166130009736 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1166130009737 dimer interface [polypeptide binding]; other site 1166130009738 active site 1166130009739 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1166130009740 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1166130009741 substrate binding site [chemical binding]; other site 1166130009742 oxyanion hole (OAH) forming residues; other site 1166130009743 trimer interface [polypeptide binding]; other site 1166130009744 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1166130009745 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1166130009746 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1166130009747 proline dipeptidase; Provisional; Region: PRK13607 1166130009748 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1166130009749 active site 1166130009750 hypothetical protein; Provisional; Region: PRK11568 1166130009751 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1166130009752 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1166130009753 potassium transporter; Provisional; Region: PRK10750 1166130009754 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1166130009755 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 1166130009756 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1166130009757 16S ribosomal RNA; NCBI Prokaryotic Genome Annotation Pipeline predicts rRNA that is too short 1166130009758 23S ribosomal RNA; NCBI Prokaryotic Genome Annotation Pipeline predicts rRNA that is too short 1166130009759 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1166130009760 FAD binding domain; Region: FAD_binding_4; pfam01565 1166130009761 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1166130009762 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1166130009763 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1166130009764 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1166130009765 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1166130009766 pantothenate kinase; Provisional; Region: PRK05439 1166130009767 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1166130009768 ATP-binding site [chemical binding]; other site 1166130009769 CoA-binding site [chemical binding]; other site 1166130009770 Mg2+-binding site [ion binding]; other site 1166130009771 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1166130009772 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166130009773 Coenzyme A binding pocket [chemical binding]; other site 1166130009774 elongation factor Tu; Reviewed; Region: PRK00049 1166130009775 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1166130009776 G1 box; other site 1166130009777 GEF interaction site [polypeptide binding]; other site 1166130009778 GTP/Mg2+ binding site [chemical binding]; other site 1166130009779 Switch I region; other site 1166130009780 G2 box; other site 1166130009781 G3 box; other site 1166130009782 Switch II region; other site 1166130009783 G4 box; other site 1166130009784 G5 box; other site 1166130009785 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1166130009786 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1166130009787 Antibiotic Binding Site [chemical binding]; other site 1166130009788 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1166130009789 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1166130009790 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1166130009791 putative homodimer interface [polypeptide binding]; other site 1166130009792 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1166130009793 heterodimer interface [polypeptide binding]; other site 1166130009794 homodimer interface [polypeptide binding]; other site 1166130009795 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1166130009796 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1166130009797 23S rRNA interface [nucleotide binding]; other site 1166130009798 L7/L12 interface [polypeptide binding]; other site 1166130009799 putative thiostrepton binding site; other site 1166130009800 L25 interface [polypeptide binding]; other site 1166130009801 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1166130009802 mRNA/rRNA interface [nucleotide binding]; other site 1166130009803 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1166130009804 23S rRNA interface [nucleotide binding]; other site 1166130009805 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1166130009806 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1166130009807 core dimer interface [polypeptide binding]; other site 1166130009808 peripheral dimer interface [polypeptide binding]; other site 1166130009809 L10 interface [polypeptide binding]; other site 1166130009810 L11 interface [polypeptide binding]; other site 1166130009811 putative EF-Tu interaction site [polypeptide binding]; other site 1166130009812 putative EF-G interaction site [polypeptide binding]; other site 1166130009813 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1166130009814 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1166130009815 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1166130009816 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1166130009817 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1166130009818 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1166130009819 RPB3 interaction site [polypeptide binding]; other site 1166130009820 RPB1 interaction site [polypeptide binding]; other site 1166130009821 RPB11 interaction site [polypeptide binding]; other site 1166130009822 RPB10 interaction site [polypeptide binding]; other site 1166130009823 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1166130009824 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1166130009825 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1166130009826 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1166130009827 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1166130009828 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1166130009829 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1166130009830 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1166130009831 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1166130009832 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1166130009833 DNA binding site [nucleotide binding] 1166130009834 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1166130009835 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1166130009836 methionine cluster; other site 1166130009837 active site 1166130009838 phosphorylation site [posttranslational modification] 1166130009839 metal binding site [ion binding]; metal-binding site 1166130009840 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1166130009841 active site 1166130009842 P-loop; other site 1166130009843 phosphorylation site [posttranslational modification] 1166130009844 Cache domain; Region: Cache_1; pfam02743 1166130009845 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1166130009846 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166130009847 metal binding site [ion binding]; metal-binding site 1166130009848 active site 1166130009849 I-site; other site 1166130009850 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 1166130009851 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1166130009852 FeS/SAM binding site; other site 1166130009853 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1166130009854 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1166130009855 ThiS interaction site; other site 1166130009856 putative active site [active] 1166130009857 tetramer interface [polypeptide binding]; other site 1166130009858 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1166130009859 thiS-thiF/thiG interaction site; other site 1166130009860 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1166130009861 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 1166130009862 ATP binding site [chemical binding]; other site 1166130009863 substrate interface [chemical binding]; other site 1166130009864 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1166130009865 thiamine phosphate binding site [chemical binding]; other site 1166130009866 active site 1166130009867 pyrophosphate binding site [ion binding]; other site 1166130009868 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1166130009869 ThiC-associated domain; Region: ThiC-associated; pfam13667 1166130009870 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1166130009871 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 1166130009872 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1166130009873 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1166130009874 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1166130009875 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1166130009876 putative NADH binding site [chemical binding]; other site 1166130009877 putative active site [active] 1166130009878 nudix motif; other site 1166130009879 putative metal binding site [ion binding]; other site 1166130009880 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1166130009881 substrate binding site [chemical binding]; other site 1166130009882 active site 1166130009883 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1166130009884 Active_site [active] 1166130009885 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 1166130009886 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1166130009887 IHF dimer interface [polypeptide binding]; other site 1166130009888 IHF - DNA interface [nucleotide binding]; other site 1166130009889 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 1166130009890 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1166130009891 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1166130009892 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1166130009893 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1166130009894 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1166130009895 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1166130009896 purine monophosphate binding site [chemical binding]; other site 1166130009897 dimer interface [polypeptide binding]; other site 1166130009898 putative catalytic residues [active] 1166130009899 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1166130009900 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1166130009901 hypothetical protein; Provisional; Region: PRK10039 1166130009902 hypothetical protein; Provisional; Region: PRK10039 1166130009903 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1166130009904 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1166130009905 proposed active site lysine [active] 1166130009906 conserved cys residue [active] 1166130009907 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 1166130009908 malate synthase A; Region: malate_syn_A; TIGR01344 1166130009909 active site 1166130009910 isocitrate lyase; Provisional; Region: PRK15063 1166130009911 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1166130009912 tetramer interface [polypeptide binding]; other site 1166130009913 active site 1166130009914 Mg2+/Mn2+ binding site [ion binding]; other site 1166130009915 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 1166130009916 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 1166130009917 Cytidylyltransferase family; Region: CTP_transf_1; cl17467 1166130009918 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1166130009919 transcriptional repressor IclR; Provisional; Region: PRK11569 1166130009920 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1166130009921 Bacterial transcriptional regulator; Region: IclR; pfam01614 1166130009922 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1166130009923 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1166130009924 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1166130009925 substrate binding pocket [chemical binding]; other site 1166130009926 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1166130009927 B12 binding site [chemical binding]; other site 1166130009928 cobalt ligand [ion binding]; other site 1166130009929 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1166130009930 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1166130009931 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1166130009932 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 1166130009933 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1166130009934 RNA binding surface [nucleotide binding]; other site 1166130009935 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 1166130009936 probable active site [active] 1166130009937 hypothetical protein; Provisional; Region: PRK10515 1166130009938 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 1166130009939 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1166130009940 non-specific DNA binding site [nucleotide binding]; other site 1166130009941 salt bridge; other site 1166130009942 sequence-specific DNA binding site [nucleotide binding]; other site 1166130009943 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1166130009944 Sodium Bile acid symporter family; Region: SBF; pfam01758 1166130009945 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 1166130009946 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 1166130009947 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166130009948 Walker A motif; other site 1166130009949 ATP binding site [chemical binding]; other site 1166130009950 Walker B motif; other site 1166130009951 arginine finger; other site 1166130009952 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1166130009953 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1166130009954 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1166130009955 hypothetical protein; Reviewed; Region: PRK09588 1166130009956 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 1166130009957 aspartate kinase III; Validated; Region: PRK09084 1166130009958 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1166130009959 nucleotide binding site [chemical binding]; other site 1166130009960 substrate binding site [chemical binding]; other site 1166130009961 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 1166130009962 lysine allosteric regulatory site; other site 1166130009963 dimer interface [polypeptide binding]; other site 1166130009964 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 1166130009965 dimer interface [polypeptide binding]; other site 1166130009966 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1166130009967 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1166130009968 active site 1166130009969 dimer interface [polypeptide binding]; other site 1166130009970 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1166130009971 dimer interface [polypeptide binding]; other site 1166130009972 active site 1166130009973 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 1166130009974 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 1166130009975 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 1166130009976 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 1166130009977 putative trimer interface [polypeptide binding]; other site 1166130009978 putative active site [active] 1166130009979 putative substrate binding site [chemical binding]; other site 1166130009980 putative CoA binding site [chemical binding]; other site 1166130009981 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1166130009982 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166130009983 Coenzyme A binding pocket [chemical binding]; other site 1166130009984 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 1166130009985 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1166130009986 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130009987 dimer interface [polypeptide binding]; other site 1166130009988 conserved gate region; other site 1166130009989 putative PBP binding loops; other site 1166130009990 ABC-ATPase subunit interface; other site 1166130009991 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130009992 dimer interface [polypeptide binding]; other site 1166130009993 conserved gate region; other site 1166130009994 putative PBP binding loops; other site 1166130009995 ABC-ATPase subunit interface; other site 1166130009996 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 1166130009997 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1166130009998 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1166130009999 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 1166130010000 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1166130010001 Walker A/P-loop; other site 1166130010002 ATP binding site [chemical binding]; other site 1166130010003 Q-loop/lid; other site 1166130010004 ABC transporter signature motif; other site 1166130010005 Walker B; other site 1166130010006 D-loop; other site 1166130010007 H-loop/switch region; other site 1166130010008 TOBE domain; Region: TOBE_2; pfam08402 1166130010009 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1166130010010 trimer interface; other site 1166130010011 sugar binding site [chemical binding]; other site 1166130010012 maltose regulon periplasmic protein; Provisional; Region: PRK10564 1166130010013 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 1166130010014 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 1166130010015 UbiA prenyltransferase family; Region: UbiA; pfam01040 1166130010016 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 1166130010017 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1166130010018 putative acyl-acceptor binding pocket; other site 1166130010019 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1166130010020 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 1166130010021 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1166130010022 hypothetical protein; Provisional; Region: PRK10428 1166130010023 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1166130010024 metal binding site 2 [ion binding]; metal-binding site 1166130010025 putative DNA binding helix; other site 1166130010026 metal binding site 1 [ion binding]; metal-binding site 1166130010027 dimer interface [polypeptide binding]; other site 1166130010028 structural Zn2+ binding site [ion binding]; other site 1166130010029 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 1166130010030 Isochorismatase family; Region: Isochorismatase; pfam00857 1166130010031 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1166130010032 catalytic triad [active] 1166130010033 dimer interface [polypeptide binding]; other site 1166130010034 conserved cis-peptide bond; other site 1166130010035 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1166130010036 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1166130010037 FMN binding site [chemical binding]; other site 1166130010038 active site 1166130010039 catalytic residues [active] 1166130010040 substrate binding site [chemical binding]; other site 1166130010041 phage shock protein G; Reviewed; Region: pspG; PRK09459 1166130010042 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1166130010043 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1166130010044 NADP binding site [chemical binding]; other site 1166130010045 dimer interface [polypeptide binding]; other site 1166130010046 replicative DNA helicase; Provisional; Region: PRK08006 1166130010047 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1166130010048 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1166130010049 Walker A motif; other site 1166130010050 ATP binding site [chemical binding]; other site 1166130010051 Walker B motif; other site 1166130010052 DNA binding loops [nucleotide binding] 1166130010053 alanine racemase; Reviewed; Region: alr; PRK00053 1166130010054 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1166130010055 active site 1166130010056 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1166130010057 substrate binding site [chemical binding]; other site 1166130010058 catalytic residues [active] 1166130010059 dimer interface [polypeptide binding]; other site 1166130010060 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1166130010061 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1166130010062 active site 1166130010063 nucleotide binding site [chemical binding]; other site 1166130010064 HIGH motif; other site 1166130010065 KMSKS motif; other site 1166130010066 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1166130010067 AAA domain; Region: AAA_28; pfam13521 1166130010068 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1166130010069 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1166130010070 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130010071 homodimer interface [polypeptide binding]; other site 1166130010072 catalytic residue [active] 1166130010073 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1166130010074 active site 1166130010075 motif I; other site 1166130010076 motif II; other site 1166130010077 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1166130010078 antimicrobial resistance protein Mig-14; Provisional; Region: PRK15312 1166130010079 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1166130010080 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1166130010081 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130010082 active site 1166130010083 phosphorylation site [posttranslational modification] 1166130010084 intermolecular recognition site; other site 1166130010085 dimerization interface [polypeptide binding]; other site 1166130010086 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1166130010087 DNA binding site [nucleotide binding] 1166130010088 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1166130010089 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1166130010090 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1166130010091 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1166130010092 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1166130010093 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1166130010094 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1166130010095 dimer interface [polypeptide binding]; other site 1166130010096 ssDNA binding site [nucleotide binding]; other site 1166130010097 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1166130010098 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1166130010099 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1166130010100 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166130010101 substrate binding pocket [chemical binding]; other site 1166130010102 membrane-bound complex binding site; other site 1166130010103 hinge residues; other site 1166130010104 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1166130010105 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1166130010106 Walker A/P-loop; other site 1166130010107 ATP binding site [chemical binding]; other site 1166130010108 Q-loop/lid; other site 1166130010109 ABC transporter signature motif; other site 1166130010110 Walker B; other site 1166130010111 D-loop; other site 1166130010112 H-loop/switch region; other site 1166130010113 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1166130010114 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130010115 dimer interface [polypeptide binding]; other site 1166130010116 conserved gate region; other site 1166130010117 putative PBP binding loops; other site 1166130010118 ABC-ATPase subunit interface; other site 1166130010119 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1166130010120 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1166130010121 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1166130010122 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 1166130010123 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1166130010124 RHS Repeat; Region: RHS_repeat; pfam05593 1166130010125 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1166130010126 RHS Repeat; Region: RHS_repeat; pfam05593 1166130010127 RHS Repeat; Region: RHS_repeat; pfam05593 1166130010128 RHS Repeat; Region: RHS_repeat; cl11982 1166130010129 RHS Repeat; Region: RHS_repeat; cl11982 1166130010130 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1166130010131 RHS Repeat; Region: RHS_repeat; pfam05593 1166130010132 RHS Repeat; Region: RHS_repeat; pfam05593 1166130010133 RHS protein; Region: RHS; pfam03527 1166130010134 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1166130010135 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 1166130010136 GIY-YIG motif/motif A; other site 1166130010137 active site 1166130010138 catalytic site [active] 1166130010139 metal binding site [ion binding]; metal-binding site 1166130010140 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 1166130010141 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 1166130010142 Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255 1166130010143 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1166130010144 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1166130010145 Cupin domain; Region: Cupin_2; cl17218 1166130010146 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1166130010147 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1166130010148 active site 1166130010149 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1166130010150 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1166130010151 DNA binding site [nucleotide binding] 1166130010152 domain linker motif; other site 1166130010153 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 1166130010154 putative dimerization interface [polypeptide binding]; other site 1166130010155 putative ligand binding site [chemical binding]; other site 1166130010156 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1166130010157 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1166130010158 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166130010159 Walker A/P-loop; other site 1166130010160 ATP binding site [chemical binding]; other site 1166130010161 Q-loop/lid; other site 1166130010162 ABC transporter signature motif; other site 1166130010163 Walker B; other site 1166130010164 D-loop; other site 1166130010165 H-loop/switch region; other site 1166130010166 TOBE domain; Region: TOBE_2; pfam08402 1166130010167 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 1166130010168 hypothetical protein; Provisional; Region: PRK11622 1166130010169 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130010170 dimer interface [polypeptide binding]; other site 1166130010171 putative PBP binding loops; other site 1166130010172 ABC-ATPase subunit interface; other site 1166130010173 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1166130010174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130010175 dimer interface [polypeptide binding]; other site 1166130010176 conserved gate region; other site 1166130010177 putative PBP binding loops; other site 1166130010178 ABC-ATPase subunit interface; other site 1166130010179 PAS domain S-box; Region: sensory_box; TIGR00229 1166130010180 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1166130010181 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166130010182 metal binding site [ion binding]; metal-binding site 1166130010183 active site 1166130010184 I-site; other site 1166130010185 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1166130010186 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1166130010187 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1166130010188 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1166130010189 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130010190 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 1166130010191 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 1166130010192 DNA binding residues [nucleotide binding] 1166130010193 dimer interface [polypeptide binding]; other site 1166130010194 [2Fe-2S] cluster binding site [ion binding]; other site 1166130010195 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1166130010196 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1166130010197 putative C-terminal domain interface [polypeptide binding]; other site 1166130010198 putative GSH binding site (G-site) [chemical binding]; other site 1166130010199 putative dimer interface [polypeptide binding]; other site 1166130010200 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 1166130010201 putative N-terminal domain interface [polypeptide binding]; other site 1166130010202 putative dimer interface [polypeptide binding]; other site 1166130010203 putative substrate binding pocket (H-site) [chemical binding]; other site 1166130010204 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1166130010205 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1166130010206 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166130010207 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130010208 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1166130010209 putative dimerization interface [polypeptide binding]; other site 1166130010210 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 1166130010211 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1166130010212 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1166130010213 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1166130010214 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1166130010215 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1166130010216 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1166130010217 Na binding site [ion binding]; other site 1166130010218 Predicted membrane protein [Function unknown]; Region: COG3162 1166130010219 acetyl-CoA synthetase; Provisional; Region: PRK00174 1166130010220 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1166130010221 active site 1166130010222 CoA binding site [chemical binding]; other site 1166130010223 acyl-activating enzyme (AAE) consensus motif; other site 1166130010224 AMP binding site [chemical binding]; other site 1166130010225 acetate binding site [chemical binding]; other site 1166130010226 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 1166130010227 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1166130010228 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1166130010229 dimerization interface [polypeptide binding]; other site 1166130010230 putative Zn2+ binding site [ion binding]; other site 1166130010231 putative DNA binding site [nucleotide binding]; other site 1166130010232 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1166130010233 EamA-like transporter family; Region: EamA; pfam00892 1166130010234 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1166130010235 EamA-like transporter family; Region: EamA; pfam00892 1166130010236 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1166130010237 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166130010238 S-adenosylmethionine binding site [chemical binding]; other site 1166130010239 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1166130010240 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166130010241 S-adenosylmethionine binding site [chemical binding]; other site 1166130010242 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1166130010243 molybdopterin cofactor binding site; other site 1166130010244 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 1166130010245 molybdopterin cofactor binding site; other site 1166130010246 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1166130010247 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1166130010248 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130010249 active site 1166130010250 phosphorylation site [posttranslational modification] 1166130010251 intermolecular recognition site; other site 1166130010252 dimerization interface [polypeptide binding]; other site 1166130010253 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1166130010254 DNA binding site [nucleotide binding] 1166130010255 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1166130010256 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1166130010257 substrate binding site [chemical binding]; other site 1166130010258 ATP binding site [chemical binding]; other site 1166130010259 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1166130010260 intersubunit interface [polypeptide binding]; other site 1166130010261 active site 1166130010262 zinc binding site [ion binding]; other site 1166130010263 Na+ binding site [ion binding]; other site 1166130010264 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 1166130010265 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1166130010266 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 1166130010267 putative ligand binding site [chemical binding]; other site 1166130010268 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1166130010269 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1166130010270 TM-ABC transporter signature motif; other site 1166130010271 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1166130010272 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1166130010273 Walker A/P-loop; other site 1166130010274 ATP binding site [chemical binding]; other site 1166130010275 Q-loop/lid; other site 1166130010276 ABC transporter signature motif; other site 1166130010277 Walker B; other site 1166130010278 D-loop; other site 1166130010279 H-loop/switch region; other site 1166130010280 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1166130010281 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166130010282 dimerization interface [polypeptide binding]; other site 1166130010283 PAS domain; Region: PAS; smart00091 1166130010284 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1166130010285 putative active site [active] 1166130010286 heme pocket [chemical binding]; other site 1166130010287 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1166130010288 dimer interface [polypeptide binding]; other site 1166130010289 phosphorylation site [posttranslational modification] 1166130010290 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166130010291 ATP binding site [chemical binding]; other site 1166130010292 Mg2+ binding site [ion binding]; other site 1166130010293 G-X-G motif; other site 1166130010294 Response regulator receiver domain; Region: Response_reg; pfam00072 1166130010295 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130010296 active site 1166130010297 phosphorylation site [posttranslational modification] 1166130010298 intermolecular recognition site; other site 1166130010299 dimerization interface [polypeptide binding]; other site 1166130010300 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1166130010301 active site 1166130010302 putative hydrolase; Provisional; Region: PRK02113 1166130010303 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 1166130010304 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 1166130010305 active site 1166130010306 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 1166130010307 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1166130010308 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 1166130010309 active site 1166130010310 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 1166130010311 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1166130010312 Walker A/P-loop; other site 1166130010313 ATP binding site [chemical binding]; other site 1166130010314 Q-loop/lid; other site 1166130010315 ABC transporter signature motif; other site 1166130010316 Walker B; other site 1166130010317 D-loop; other site 1166130010318 H-loop/switch region; other site 1166130010319 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 1166130010320 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1166130010321 Walker A/P-loop; other site 1166130010322 ATP binding site [chemical binding]; other site 1166130010323 Q-loop/lid; other site 1166130010324 ABC transporter signature motif; other site 1166130010325 Walker B; other site 1166130010326 D-loop; other site 1166130010327 H-loop/switch region; other site 1166130010328 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1166130010329 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 1166130010330 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 1166130010331 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 1166130010332 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 1166130010333 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 1166130010334 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166130010335 DNA-binding site [nucleotide binding]; DNA binding site 1166130010336 UTRA domain; Region: UTRA; pfam07702 1166130010337 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1166130010338 dimer interface [polypeptide binding]; other site 1166130010339 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1166130010340 hypothetical protein; Provisional; Region: PRK10220 1166130010341 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1166130010342 PhnA protein; Region: PhnA; pfam03831 1166130010343 hypothetical protein; Provisional; Region: PRK09866 1166130010344 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1166130010345 G1 box; other site 1166130010346 GTP/Mg2+ binding site [chemical binding]; other site 1166130010347 G2 box; other site 1166130010348 Switch I region; other site 1166130010349 G3 box; other site 1166130010350 Switch II region; other site 1166130010351 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1166130010352 G2 box; other site 1166130010353 Switch I region; other site 1166130010354 G3 box; other site 1166130010355 Switch II region; other site 1166130010356 G4 box; other site 1166130010357 G5 box; other site 1166130010358 YjcZ-like protein; Region: YjcZ; pfam13990 1166130010359 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 1166130010360 proline/glycine betaine transporter; Provisional; Region: PRK10642 1166130010361 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130010362 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130010363 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 1166130010364 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 1166130010365 Predicted membrane protein (DUF2238); Region: DUF2238; cl01464 1166130010366 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1166130010367 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1166130010368 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130010369 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1166130010370 putative transcriptional regulator; Provisional; Region: PRK11640 1166130010371 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 1166130010372 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1166130010373 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1166130010374 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1166130010375 DsbD alpha interface [polypeptide binding]; other site 1166130010376 catalytic residues [active] 1166130010377 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 1166130010378 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1166130010379 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1166130010380 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1166130010381 Aspartase; Region: Aspartase; cd01357 1166130010382 active sites [active] 1166130010383 tetramer interface [polypeptide binding]; other site 1166130010384 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 1166130010385 putative transporter; Provisional; Region: PRK11021 1166130010386 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1166130010387 oligomerisation interface [polypeptide binding]; other site 1166130010388 mobile loop; other site 1166130010389 roof hairpin; other site 1166130010390 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1166130010391 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1166130010392 ring oligomerisation interface [polypeptide binding]; other site 1166130010393 ATP/Mg binding site [chemical binding]; other site 1166130010394 stacking interactions; other site 1166130010395 hinge regions; other site 1166130010396 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 1166130010397 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1166130010398 HAMP domain; Region: HAMP; pfam00672 1166130010399 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1166130010400 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166130010401 dimer interface [polypeptide binding]; other site 1166130010402 putative CheW interface [polypeptide binding]; other site 1166130010403 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 1166130010404 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1166130010405 FeS/SAM binding site; other site 1166130010406 elongation factor P; Validated; Region: PRK00529 1166130010407 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1166130010408 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1166130010409 RNA binding site [nucleotide binding]; other site 1166130010410 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1166130010411 RNA binding site [nucleotide binding]; other site 1166130010412 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 1166130010413 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1166130010414 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1166130010415 DNA binding residues [nucleotide binding] 1166130010416 dimerization interface [polypeptide binding]; other site 1166130010417 multidrug efflux system protein; Provisional; Region: PRK11431 1166130010418 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 1166130010419 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1166130010420 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 1166130010421 Iron-sulfur protein interface; other site 1166130010422 proximal quinone binding site [chemical binding]; other site 1166130010423 C-subunit interface; other site 1166130010424 distal quinone binding site; other site 1166130010425 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 1166130010426 D-subunit interface [polypeptide binding]; other site 1166130010427 Iron-sulfur protein interface; other site 1166130010428 proximal quinone binding site [chemical binding]; other site 1166130010429 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 1166130010430 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1166130010431 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 1166130010432 L-aspartate oxidase; Provisional; Region: PRK06175 1166130010433 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1166130010434 poxB regulator PoxA; Provisional; Region: PRK09350 1166130010435 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1166130010436 motif 1; other site 1166130010437 dimer interface [polypeptide binding]; other site 1166130010438 active site 1166130010439 motif 2; other site 1166130010440 motif 3; other site 1166130010441 putative mechanosensitive channel protein; Provisional; Region: PRK10929 1166130010442 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1166130010443 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1166130010444 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 1166130010445 GTPase RsgA; Reviewed; Region: PRK12288 1166130010446 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1166130010447 RNA binding site [nucleotide binding]; other site 1166130010448 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1166130010449 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1166130010450 GTP/Mg2+ binding site [chemical binding]; other site 1166130010451 G4 box; other site 1166130010452 G5 box; other site 1166130010453 G1 box; other site 1166130010454 Switch I region; other site 1166130010455 G2 box; other site 1166130010456 G3 box; other site 1166130010457 Switch II region; other site 1166130010458 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1166130010459 catalytic site [active] 1166130010460 putative active site [active] 1166130010461 putative substrate binding site [chemical binding]; other site 1166130010462 dimer interface [polypeptide binding]; other site 1166130010463 epoxyqueuosine reductase; Region: TIGR00276 1166130010464 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1166130010465 putative carbohydrate kinase; Provisional; Region: PRK10565 1166130010466 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1166130010467 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1166130010468 putative substrate binding site [chemical binding]; other site 1166130010469 putative ATP binding site [chemical binding]; other site 1166130010470 ADP-binding protein; Provisional; Region: PRK10646 1166130010471 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 1166130010472 AMIN domain; Region: AMIN; pfam11741 1166130010473 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1166130010474 active site 1166130010475 metal binding site [ion binding]; metal-binding site 1166130010476 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1166130010477 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166130010478 ATP binding site [chemical binding]; other site 1166130010479 Mg2+ binding site [ion binding]; other site 1166130010480 G-X-G motif; other site 1166130010481 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 1166130010482 ATP binding site [chemical binding]; other site 1166130010483 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1166130010484 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1166130010485 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1166130010486 bacterial Hfq-like; Region: Hfq; cd01716 1166130010487 hexamer interface [polypeptide binding]; other site 1166130010488 Sm1 motif; other site 1166130010489 RNA binding site [nucleotide binding]; other site 1166130010490 Sm2 motif; other site 1166130010491 GTPase HflX; Provisional; Region: PRK11058 1166130010492 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1166130010493 HflX GTPase family; Region: HflX; cd01878 1166130010494 G1 box; other site 1166130010495 GTP/Mg2+ binding site [chemical binding]; other site 1166130010496 Switch I region; other site 1166130010497 G2 box; other site 1166130010498 G3 box; other site 1166130010499 Switch II region; other site 1166130010500 G4 box; other site 1166130010501 G5 box; other site 1166130010502 FtsH protease regulator HflK; Provisional; Region: PRK10930 1166130010503 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 1166130010504 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1166130010505 FtsH protease regulator HflC; Provisional; Region: PRK11029 1166130010506 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1166130010507 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 1166130010508 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1166130010509 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1166130010510 GDP-binding site [chemical binding]; other site 1166130010511 ACT binding site; other site 1166130010512 IMP binding site; other site 1166130010513 Predicted transcriptional regulator [Transcription]; Region: COG1959 1166130010514 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166130010515 DNA-binding site [nucleotide binding]; DNA binding site 1166130010516 exoribonuclease R; Provisional; Region: PRK11642 1166130010517 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1166130010518 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1166130010519 RNB domain; Region: RNB; pfam00773 1166130010520 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1166130010521 RNA binding site [nucleotide binding]; other site 1166130010522 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 1166130010523 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1166130010524 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1166130010525 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 1166130010526 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1166130010527 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 1166130010528 Predicted membrane protein [Function unknown]; Region: COG3766 1166130010529 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1166130010530 Protein of unknown function (DUF1190); Region: DUF1190; cl10031 1166130010531 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1166130010532 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130010533 metabolite-proton symporter; Region: 2A0106; TIGR00883 1166130010534 putative substrate translocation pore; other site 1166130010535 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1166130010536 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 1166130010537 FAD binding site [chemical binding]; other site 1166130010538 substrate binding site [chemical binding]; other site 1166130010539 catalytic residues [active] 1166130010540 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166130010541 dimerization interface [polypeptide binding]; other site 1166130010542 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1166130010543 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166130010544 dimer interface [polypeptide binding]; other site 1166130010545 putative CheW interface [polypeptide binding]; other site 1166130010546 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1166130010547 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 1166130010548 esterase; Provisional; Region: PRK10566 1166130010549 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1166130010550 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1166130010551 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130010552 putative substrate translocation pore; other site 1166130010553 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1166130010554 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1166130010555 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1166130010556 generic binding surface I; other site 1166130010557 generic binding surface II; other site 1166130010558 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1166130010559 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1166130010560 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1166130010561 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1166130010562 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1166130010563 EamA-like transporter family; Region: EamA; pfam00892 1166130010564 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 1166130010565 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 1166130010566 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 1166130010567 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 1166130010568 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1166130010569 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1166130010570 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1166130010571 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 1166130010572 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 1166130010573 Hemerythrin-like domain; Region: Hr-like; cd12108 1166130010574 Fe binding site [ion binding]; other site 1166130010575 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1166130010576 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1166130010577 dimer interface [polypeptide binding]; other site 1166130010578 ligand binding site [chemical binding]; other site 1166130010579 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166130010580 dimerization interface [polypeptide binding]; other site 1166130010581 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166130010582 dimer interface [polypeptide binding]; other site 1166130010583 putative CheW interface [polypeptide binding]; other site 1166130010584 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1166130010585 EamA-like transporter family; Region: EamA; pfam00892 1166130010586 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1166130010587 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1166130010588 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130010589 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130010590 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1166130010591 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1166130010592 NADP binding site [chemical binding]; other site 1166130010593 Predicted transcriptional regulators [Transcription]; Region: COG1733 1166130010594 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1166130010595 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 1166130010596 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1166130010597 active site 1166130010598 metal binding site [ion binding]; metal-binding site 1166130010599 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1166130010600 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1166130010601 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1166130010602 active site 1166130010603 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 1166130010604 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 1166130010605 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1166130010606 Domain of unknown function DUF21; Region: DUF21; pfam01595 1166130010607 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1166130010608 Transporter associated domain; Region: CorC_HlyC; smart01091 1166130010609 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1166130010610 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1166130010611 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1166130010612 Surface antigen; Region: Bac_surface_Ag; pfam01103 1166130010613 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1166130010614 Family of unknown function (DUF490); Region: DUF490; pfam04357 1166130010615 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1166130010616 putative active site pocket [active] 1166130010617 dimerization interface [polypeptide binding]; other site 1166130010618 putative catalytic residue [active] 1166130010619 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1166130010620 dimer interface [polypeptide binding]; other site 1166130010621 substrate binding site [chemical binding]; other site 1166130010622 metal binding sites [ion binding]; metal-binding site 1166130010623 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 1166130010624 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1166130010625 putative ligand binding site [chemical binding]; other site 1166130010626 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1166130010627 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1166130010628 Walker A/P-loop; other site 1166130010629 ATP binding site [chemical binding]; other site 1166130010630 Q-loop/lid; other site 1166130010631 ABC transporter signature motif; other site 1166130010632 Walker B; other site 1166130010633 D-loop; other site 1166130010634 H-loop/switch region; other site 1166130010635 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1166130010636 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1166130010637 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1166130010638 TM-ABC transporter signature motif; other site 1166130010639 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1166130010640 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1166130010641 TM-ABC transporter signature motif; other site 1166130010642 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1166130010643 dimer interface [polypeptide binding]; other site 1166130010644 ligand binding site [chemical binding]; other site 1166130010645 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1166130010646 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166130010647 dimer interface [polypeptide binding]; other site 1166130010648 putative CheW interface [polypeptide binding]; other site 1166130010649 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 1166130010650 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1166130010651 AMP binding site [chemical binding]; other site 1166130010652 metal binding site [ion binding]; metal-binding site 1166130010653 active site 1166130010654 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 1166130010655 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1166130010656 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1166130010657 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1166130010658 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 1166130010659 active site 1166130010660 catalytic residues [active] 1166130010661 hypothetical protein; Provisional; Region: PRK05255 1166130010662 peptidase PmbA; Provisional; Region: PRK11040 1166130010663 cytochrome b562; Provisional; Region: PRK15058 1166130010664 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1166130010665 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1166130010666 NADP binding site [chemical binding]; other site 1166130010667 dimer interface [polypeptide binding]; other site 1166130010668 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130010669 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 1166130010670 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1166130010671 dimerization interface [polypeptide binding]; other site 1166130010672 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 1166130010673 conserved hypothetical protein EF_0830/AHA_3911; Region: EF_0830; TIGR03577 1166130010674 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 1166130010675 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 1166130010676 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 1166130010677 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 1166130010678 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1166130010679 active site 1166130010680 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 1166130010681 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 1166130010682 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1166130010683 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 1166130010684 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1166130010685 HTH domain; Region: HTH_11; pfam08279 1166130010686 Mga helix-turn-helix domain; Region: Mga; pfam05043 1166130010687 PRD domain; Region: PRD; pfam00874 1166130010688 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1166130010689 active site 1166130010690 P-loop; other site 1166130010691 phosphorylation site [posttranslational modification] 1166130010692 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1166130010693 active site 1166130010694 phosphorylation site [posttranslational modification] 1166130010695 short chain dehydrogenase; Provisional; Region: PRK06180 1166130010696 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1166130010697 NADP binding site [chemical binding]; other site 1166130010698 active site 1166130010699 steroid binding site; other site 1166130010700 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1166130010701 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130010702 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1166130010703 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 1166130010704 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1166130010705 FeS/SAM binding site; other site 1166130010706 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1166130010707 ATP cone domain; Region: ATP-cone; pfam03477 1166130010708 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1166130010709 effector binding site; other site 1166130010710 active site 1166130010711 Zn binding site [ion binding]; other site 1166130010712 glycine loop; other site 1166130010713 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 1166130010714 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1166130010715 Ca binding site [ion binding]; other site 1166130010716 active site 1166130010717 catalytic site [active] 1166130010718 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1166130010719 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 1166130010720 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1166130010721 active site turn [active] 1166130010722 phosphorylation site [posttranslational modification] 1166130010723 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1166130010724 trehalose repressor; Provisional; Region: treR; PRK09492 1166130010725 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1166130010726 DNA binding site [nucleotide binding] 1166130010727 domain linker motif; other site 1166130010728 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 1166130010729 dimerization interface [polypeptide binding]; other site 1166130010730 ligand binding site [chemical binding]; other site 1166130010731 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 1166130010732 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1166130010733 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1166130010734 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1166130010735 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1166130010736 motif II; other site 1166130010737 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1166130010738 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 1166130010739 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 1166130010740 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 1166130010741 active site 1166130010742 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 1166130010743 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1166130010744 homotrimer interaction site [polypeptide binding]; other site 1166130010745 putative active site [active] 1166130010746 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 1166130010747 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 1166130010748 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 1166130010749 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 1166130010750 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1166130010751 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1166130010752 PyrBI operon leader peptide; Region: PyrBI_leader; cl11578 1166130010753 Arginine repressor [Transcription]; Region: ArgR; COG1438 1166130010754 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1166130010755 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1166130010756 Predicted membrane protein [Function unknown]; Region: COG1288 1166130010757 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1166130010758 ornithine carbamoyltransferase; Validated; Region: PRK02102 1166130010759 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1166130010760 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1166130010761 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1166130010762 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1166130010763 putative substrate binding site [chemical binding]; other site 1166130010764 nucleotide binding site [chemical binding]; other site 1166130010765 nucleotide binding site [chemical binding]; other site 1166130010766 homodimer interface [polypeptide binding]; other site 1166130010767 arginine deiminase; Provisional; Region: PRK01388 1166130010768 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1166130010769 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 1166130010770 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1166130010771 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1166130010772 RNase E inhibitor protein; Provisional; Region: PRK11191 1166130010773 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 1166130010774 active site 1166130010775 dinuclear metal binding site [ion binding]; other site 1166130010776 dimerization interface [polypeptide binding]; other site 1166130010777 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166130010778 Coenzyme A binding pocket [chemical binding]; other site 1166130010779 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1166130010780 Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987 1166130010781 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1166130010782 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1166130010783 HIGH motif; other site 1166130010784 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1166130010785 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1166130010786 active site 1166130010787 KMSKS motif; other site 1166130010788 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1166130010789 tRNA binding surface [nucleotide binding]; other site 1166130010790 anticodon binding site; other site 1166130010791 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1166130010792 DNA polymerase III subunit chi; Validated; Region: PRK05728 1166130010793 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1166130010794 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1166130010795 interface (dimer of trimers) [polypeptide binding]; other site 1166130010796 Substrate-binding/catalytic site; other site 1166130010797 Zn-binding sites [ion binding]; other site 1166130010798 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 1166130010799 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1166130010800 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 1166130010801 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1166130010802 dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361 1166130010803 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 1166130010804 DAK2 domain; Region: Dak2; pfam02734 1166130010805 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1166130010806 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1166130010807 putative NAD(P) binding site [chemical binding]; other site 1166130010808 putative substrate binding site [chemical binding]; other site 1166130010809 catalytic Zn binding site [ion binding]; other site 1166130010810 structural Zn binding site [ion binding]; other site 1166130010811 dimer interface [polypeptide binding]; other site 1166130010812 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1166130010813 catalytic residues [active] 1166130010814 Protein of unknown function (DUF2589); Region: DUF2589; pfam11655 1166130010815 Protein of unknown function (DUF2589); Region: DUF2589; pfam11655 1166130010816 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1166130010817 catalytic residues [active] 1166130010818 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 1166130010819 active site 1166130010820 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1166130010821 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1166130010822 active site 1166130010823 phosphorylation site [posttranslational modification] 1166130010824 intermolecular recognition site; other site 1166130010825 dimerization interface [polypeptide binding]; other site 1166130010826 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1166130010827 DNA binding residues [nucleotide binding] 1166130010828 dimerization interface [polypeptide binding]; other site 1166130010829 integrase; Provisional; Region: PRK09692 1166130010830 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1166130010831 active site 1166130010832 Int/Topo IB signature motif; other site 1166130010833 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1166130010834 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1166130010835 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1166130010836 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1166130010837 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1166130010838 Protein of unknown function DUF45; Region: DUF45; pfam01863 1166130010839 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 1166130010840 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1166130010841 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1166130010842 ATP binding site [chemical binding]; other site 1166130010843 putative Mg++ binding site [ion binding]; other site 1166130010844 Protein of unknown function DUF262; Region: DUF262; pfam03235 1166130010845 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1166130010846 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1166130010847 Protein of unknown function DUF262; Region: DUF262; pfam03235 1166130010848 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1166130010849 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1166130010850 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1166130010851 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1166130010852 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1166130010853 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1166130010854 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1166130010855 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 1166130010856 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 1166130010857 Predicted GTPase [General function prediction only]; Region: COG3596 1166130010858 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166130010859 YfjP GTPase; Region: YfjP; cd11383 1166130010860 G1 box; other site 1166130010861 Walker A/P-loop; other site 1166130010862 GTP/Mg2+ binding site [chemical binding]; other site 1166130010863 ATP binding site [chemical binding]; other site 1166130010864 Switch I region; other site 1166130010865 G2 box; other site 1166130010866 Switch II region; other site 1166130010867 G3 box; other site 1166130010868 G4 box; other site 1166130010869 G5 box; other site 1166130010870 Domain of unknown function (DUF932); Region: DUF932; pfam06067 1166130010871 Predicted transcriptional regulator [Transcription]; Region: COG2378 1166130010872 WYL domain; Region: WYL; cl14852 1166130010873 Antirestriction protein; Region: Antirestrict; pfam03230 1166130010874 hypothetical protein; Reviewed; Region: PRK00024 1166130010875 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1166130010876 MPN+ (JAMM) motif; other site 1166130010877 Zinc-binding site [ion binding]; other site 1166130010878 Protein of unknown function (DUF987); Region: DUF987; pfam06174 1166130010879 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 1166130010880 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 1166130010881 Uncharacterized conserved protein [Function unknown]; Region: COG4127 1166130010882 Restriction endonuclease; Region: Mrr_cat; pfam04471 1166130010883 integrase; Provisional; Region: PRK09692 1166130010884 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1166130010885 active site 1166130010886 Int/Topo IB signature motif; other site 1166130010887 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166130010888 Walker A/P-loop; other site 1166130010889 ATP binding site [chemical binding]; other site 1166130010890 AAA domain; Region: AAA_21; pfam13304 1166130010891 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166130010892 ABC transporter signature motif; other site 1166130010893 Walker B; other site 1166130010894 D-loop; other site 1166130010895 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1166130010896 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1166130010897 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1166130010898 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1166130010899 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1166130010900 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166130010901 S-adenosylmethionine binding site [chemical binding]; other site 1166130010902 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1166130010903 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1166130010904 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1166130010905 ATP binding site [chemical binding]; other site 1166130010906 putative Mg++ binding site [ion binding]; other site 1166130010907 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 1166130010908 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 1166130010909 Domain of unknown function (DUF4268); Region: DUF4268; pfam14088 1166130010910 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1166130010911 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1166130010912 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1166130010913 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1166130010914 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1166130010915 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1166130010916 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1166130010917 Transposase; Region: HTH_Tnp_1; pfam01527 1166130010918 HTH-like domain; Region: HTH_21; pfam13276 1166130010919 Integrase core domain; Region: rve; pfam00665 1166130010920 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1166130010921 Integrase core domain; Region: rve_2; pfam13333 1166130010922 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1166130010923 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1166130010924 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1166130010925 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 1166130010926 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1166130010927 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1166130010928 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1166130010929 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1166130010930 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 1166130010931 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1166130010932 trimer interface [polypeptide binding]; other site 1166130010933 active site 1166130010934 substrate binding site [chemical binding]; other site 1166130010935 CoA binding site [chemical binding]; other site 1166130010936 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1166130010937 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130010938 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1166130010939 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130010940 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1166130010941 dimerization interface [polypeptide binding]; other site 1166130010942 substrate binding pocket [chemical binding]; other site 1166130010943 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1166130010944 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1166130010945 DoxX; Region: DoxX; pfam07681 1166130010946 Predicted transcriptional regulators [Transcription]; Region: COG1733 1166130010947 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1166130010948 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1166130010949 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1166130010950 substrate binding pocket [chemical binding]; other site 1166130010951 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1166130010952 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1166130010953 putative active site [active] 1166130010954 catalytic site [active] 1166130010955 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1166130010956 putative active site [active] 1166130010957 catalytic site [active] 1166130010958 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1166130010959 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1166130010960 ATP binding site [chemical binding]; other site 1166130010961 putative Mg++ binding site [ion binding]; other site 1166130010962 nucleotide binding region [chemical binding]; other site 1166130010963 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 1166130010964 ATP-binding site [chemical binding]; other site 1166130010965 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 1166130010966 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1166130010967 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1166130010968 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1166130010969 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1166130010970 Walker A/P-loop; other site 1166130010971 ATP binding site [chemical binding]; other site 1166130010972 Q-loop/lid; other site 1166130010973 ABC transporter signature motif; other site 1166130010974 Walker B; other site 1166130010975 D-loop; other site 1166130010976 H-loop/switch region; other site 1166130010977 TOBE domain; Region: TOBE_2; pfam08402 1166130010978 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1166130010979 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1166130010980 active site 1166130010981 metal binding site [ion binding]; metal-binding site 1166130010982 hexamer interface [polypeptide binding]; other site 1166130010983 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1166130010984 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130010985 dimer interface [polypeptide binding]; other site 1166130010986 conserved gate region; other site 1166130010987 putative PBP binding loops; other site 1166130010988 ABC-ATPase subunit interface; other site 1166130010989 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130010990 dimer interface [polypeptide binding]; other site 1166130010991 conserved gate region; other site 1166130010992 putative PBP binding loops; other site 1166130010993 ABC-ATPase subunit interface; other site 1166130010994 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1166130010995 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1166130010996 N-terminal plug; other site 1166130010997 ligand-binding site [chemical binding]; other site 1166130010998 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1166130010999 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1166130011000 Walker A/P-loop; other site 1166130011001 ATP binding site [chemical binding]; other site 1166130011002 Q-loop/lid; other site 1166130011003 ABC transporter signature motif; other site 1166130011004 Walker B; other site 1166130011005 D-loop; other site 1166130011006 H-loop/switch region; other site 1166130011007 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1166130011008 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1166130011009 ABC-ATPase subunit interface; other site 1166130011010 dimer interface [polypeptide binding]; other site 1166130011011 putative PBP binding regions; other site 1166130011012 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1166130011013 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1166130011014 ABC-ATPase subunit interface; other site 1166130011015 dimer interface [polypeptide binding]; other site 1166130011016 putative PBP binding regions; other site 1166130011017 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1166130011018 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1166130011019 siderophore binding site; other site 1166130011020 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1166130011021 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1166130011022 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1166130011023 putative active site [active] 1166130011024 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 1166130011025 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1166130011026 Protein export membrane protein; Region: SecD_SecF; cl14618 1166130011027 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1166130011028 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1166130011029 HlyD family secretion protein; Region: HlyD_3; pfam13437 1166130011030 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1166130011031 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1166130011032 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1166130011033 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1166130011034 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166130011035 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130011036 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461 1166130011037 putative substrate binding pocket [chemical binding]; other site 1166130011038 putative dimerization interface [polypeptide binding]; other site 1166130011039 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1166130011040 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130011041 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1166130011042 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1166130011043 N-terminal plug; other site 1166130011044 ligand-binding site [chemical binding]; other site 1166130011045 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1166130011046 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1166130011047 active site turn [active] 1166130011048 phosphorylation site [posttranslational modification] 1166130011049 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1166130011050 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1166130011051 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1166130011052 putative active site [active] 1166130011053 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1166130011054 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1166130011055 DNA binding site [nucleotide binding] 1166130011056 flagellar biosynthesis sigma factor; Provisional; Region: PRK12427 1166130011057 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1166130011058 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1166130011059 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1166130011060 DNA binding residues [nucleotide binding] 1166130011061 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1166130011062 NlpC/P60 family; Region: NLPC_P60; pfam00877 1166130011063 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1166130011064 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166130011065 DNA-binding site [nucleotide binding]; DNA binding site 1166130011066 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1166130011067 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130011068 homodimer interface [polypeptide binding]; other site 1166130011069 catalytic residue [active] 1166130011070 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 1166130011071 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1166130011072 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1166130011073 oligomer interface [polypeptide binding]; other site 1166130011074 active site residues [active] 1166130011075 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 1166130011076 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 1166130011077 FosA, a Fosfomycin resistance protein, catalyzes the addition of glutathione to the antibiotic fosfomycin, making it inactive; Region: FosA; cd07244 1166130011078 dimer interface [polypeptide binding]; other site 1166130011079 Mn binding site [ion binding]; other site 1166130011080 K binding site [ion binding]; other site 1166130011081 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1166130011082 transcriptional regulator SlyA; Provisional; Region: PRK03573 1166130011083 MarR family; Region: MarR; pfam01047 1166130011084 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1166130011085 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1166130011086 HlyD family secretion protein; Region: HlyD_3; pfam13437 1166130011087 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 1166130011088 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 1166130011089 CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241 1166130011090 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 1166130011091 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 1166130011092 Uncharacterized conserved protein (DUF2164); Region: DUF2164; cl02278 1166130011093 Protein of unknown function (DUF445); Region: DUF445; pfam04286 1166130011094 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1166130011095 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1166130011096 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1166130011097 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130011098 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166130011099 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130011100 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_5; cd08426 1166130011101 putative dimerization interface [polypeptide binding]; other site 1166130011102 Nucleoside recognition; Region: Gate; pfam07670 1166130011103 hypothetical protein; Provisional; Region: PRK10519 1166130011104 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 1166130011105 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1166130011106 metal binding site [ion binding]; metal-binding site 1166130011107 putative dimer interface [polypeptide binding]; other site 1166130011108 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1166130011109 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1166130011110 active site 1166130011111 metal binding site [ion binding]; metal-binding site 1166130011112 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 1166130011113 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1166130011114 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1166130011115 NAD(P) binding site [chemical binding]; other site 1166130011116 catalytic residues [active] 1166130011117 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 1166130011118 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1166130011119 P-loop, Walker A motif; other site 1166130011120 Base recognition motif; other site 1166130011121 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1166130011122 Uncharacterized small protein [Function unknown]; Region: COG2879 1166130011123 carbon starvation protein A; Provisional; Region: PRK15015 1166130011124 Carbon starvation protein CstA; Region: CstA; pfam02554 1166130011125 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1166130011126 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1166130011127 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1166130011128 dimer interface [polypeptide binding]; other site 1166130011129 ligand binding site [chemical binding]; other site 1166130011130 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166130011131 dimerization interface [polypeptide binding]; other site 1166130011132 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166130011133 dimer interface [polypeptide binding]; other site 1166130011134 putative CheW interface [polypeptide binding]; other site 1166130011135 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166130011136 Coenzyme A binding pocket [chemical binding]; other site 1166130011137 phosphoglycerol transferase I; Provisional; Region: PRK03776 1166130011138 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1166130011139 hypothetical protein; Provisional; Region: PRK11667 1166130011140 DNA replication protein DnaC; Validated; Region: PRK07952 1166130011141 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166130011142 Walker A motif; other site 1166130011143 ATP binding site [chemical binding]; other site 1166130011144 Walker B motif; other site 1166130011145 primosomal protein DnaI; Provisional; Region: PRK02854 1166130011146 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1166130011147 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1166130011148 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1166130011149 putative Zn2+ binding site [ion binding]; other site 1166130011150 putative DNA binding site [nucleotide binding]; other site 1166130011151 hypothetical protein; Provisional; Region: PRK09917 1166130011152 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1166130011153 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1166130011154 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1166130011155 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1166130011156 DNA binding residues [nucleotide binding] 1166130011157 dimerization interface [polypeptide binding]; other site 1166130011158 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 1166130011159 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1166130011160 DNA binding residues [nucleotide binding] 1166130011161 dimerization interface [polypeptide binding]; other site 1166130011162 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1166130011163 putative deacylase active site [active] 1166130011164 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1166130011165 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1166130011166 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 1166130011167 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1166130011168 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1166130011169 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1166130011170 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166130011171 metal binding site [ion binding]; metal-binding site 1166130011172 active site 1166130011173 I-site; other site 1166130011174 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 1166130011175 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 1166130011176 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 1166130011177 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166130011178 S-adenosylmethionine binding site [chemical binding]; other site 1166130011179 DNA polymerase III subunit psi; Validated; Region: PRK06856 1166130011180 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 1166130011181 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166130011182 Coenzyme A binding pocket [chemical binding]; other site 1166130011183 dUMP phosphatase; Provisional; Region: PRK09449 1166130011184 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1166130011185 motif II; other site 1166130011186 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1166130011187 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1166130011188 G1 box; other site 1166130011189 putative GEF interaction site [polypeptide binding]; other site 1166130011190 GTP/Mg2+ binding site [chemical binding]; other site 1166130011191 Switch I region; other site 1166130011192 G2 box; other site 1166130011193 G3 box; other site 1166130011194 Switch II region; other site 1166130011195 G4 box; other site 1166130011196 G5 box; other site 1166130011197 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1166130011198 periplasmic protein; Provisional; Region: PRK10568 1166130011199 BON domain; Region: BON; pfam04972 1166130011200 BON domain; Region: BON; pfam04972 1166130011201 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1166130011202 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1166130011203 active site 1166130011204 nucleophile elbow; other site 1166130011205 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1166130011206 active site 1166130011207 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 1166130011208 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 1166130011209 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1166130011210 hypothetical protein; Provisional; Region: PRK10977 1166130011211 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1166130011212 intersubunit interface [polypeptide binding]; other site 1166130011213 active site 1166130011214 catalytic residue [active] 1166130011215 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1166130011216 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1166130011217 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1166130011218 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1166130011219 phosphopentomutase; Provisional; Region: PRK05362 1166130011220 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1166130011221 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1166130011222 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1166130011223 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 1166130011224 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 1166130011225 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1166130011226 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1166130011227 hypothetical protein; Provisional; Region: PRK11246 1166130011228 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 1166130011229 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1166130011230 motif II; other site 1166130011231 DNA repair protein RadA; Region: sms; TIGR00416 1166130011232 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1166130011233 Walker A motif/ATP binding site; other site 1166130011234 ATP binding site [chemical binding]; other site 1166130011235 Walker B motif; other site 1166130011236 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1166130011237 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1166130011238 non-specific DNA binding site [nucleotide binding]; other site 1166130011239 salt bridge; other site 1166130011240 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 1166130011241 sequence-specific DNA binding site [nucleotide binding]; other site 1166130011242 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 1166130011243 active site 1166130011244 (T/H)XGH motif; other site 1166130011245 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1166130011246 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1166130011247 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1166130011248 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1166130011249 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1166130011250 ABC transporter; Region: ABC_tran_2; pfam12848 1166130011251 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1166130011252 lytic murein transglycosylase; Provisional; Region: PRK11619 1166130011253 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1166130011254 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1166130011255 catalytic residue [active] 1166130011256 Trp operon repressor; Provisional; Region: PRK01381 1166130011257 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 1166130011258 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1166130011259 catalytic core [active] 1166130011260 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 1166130011261 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130011262 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1166130011263 hypothetical protein; Provisional; Region: PRK10756 1166130011264 CreA protein; Region: CreA; pfam05981 1166130011265 DNA-binding response regulator CreB; Provisional; Region: PRK11083 1166130011266 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130011267 active site 1166130011268 phosphorylation site [posttranslational modification] 1166130011269 intermolecular recognition site; other site 1166130011270 dimerization interface [polypeptide binding]; other site 1166130011271 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1166130011272 DNA binding site [nucleotide binding] 1166130011273 sensory histidine kinase CreC; Provisional; Region: PRK11100 1166130011274 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166130011275 dimerization interface [polypeptide binding]; other site 1166130011276 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1166130011277 dimer interface [polypeptide binding]; other site 1166130011278 phosphorylation site [posttranslational modification] 1166130011279 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166130011280 ATP binding site [chemical binding]; other site 1166130011281 Mg2+ binding site [ion binding]; other site 1166130011282 G-X-G motif; other site 1166130011283 Inner membrane protein CreD; Region: CreD; cl01844 1166130011284 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1166130011285 two-component response regulator; Provisional; Region: PRK11173 1166130011286 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130011287 active site 1166130011288 phosphorylation site [posttranslational modification] 1166130011289 intermolecular recognition site; other site 1166130011290 dimerization interface [polypeptide binding]; other site 1166130011291 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1166130011292 DNA binding site [nucleotide binding] 1166130011293 putative RNA methyltransferase; Provisional; Region: PRK10433 1166130011294 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1166130011295 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 1166130011296 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1166130011297 putative catalytic residues [active] 1166130011298 putative nucleotide binding site [chemical binding]; other site 1166130011299 putative aspartate binding site [chemical binding]; other site 1166130011300 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 1166130011301 dimer interface [polypeptide binding]; other site 1166130011302 putative threonine allosteric regulatory site; other site 1166130011303 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 1166130011304 putative threonine allosteric regulatory site; other site 1166130011305 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1166130011306 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1166130011307 homoserine kinase; Provisional; Region: PRK01212 1166130011308 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1166130011309 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1166130011310 threonine synthase; Validated; Region: PRK09225 1166130011311 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1166130011312 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1166130011313 catalytic residue [active] 1166130011314 hypothetical protein; Validated; Region: PRK02101 1166130011315 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1166130011316 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1166130011317 transaldolase-like protein; Provisional; Region: PTZ00411 1166130011318 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1166130011319 active site 1166130011320 dimer interface [polypeptide binding]; other site 1166130011321 catalytic residue [active] 1166130011322 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1166130011323 MPT binding site; other site 1166130011324 trimer interface [polypeptide binding]; other site 1166130011325 metabolite-proton symporter; Region: 2A0106; TIGR00883 1166130011326 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130011327 putative substrate translocation pore; other site 1166130011328 hypothetical protein; Provisional; Region: PRK10659 1166130011329 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1166130011330 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1166130011331 nucleotide binding site [chemical binding]; other site 1166130011332 chaperone protein DnaJ; Provisional; Region: PRK10767 1166130011333 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1166130011334 HSP70 interaction site [polypeptide binding]; other site 1166130011335 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1166130011336 substrate binding site [polypeptide binding]; other site 1166130011337 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1166130011338 Zn binding sites [ion binding]; other site 1166130011339 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1166130011340 dimer interface [polypeptide binding]; other site 1166130011341 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 1166130011342 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 1166130011343 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130011344 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 1166130011345 putative dimerization interface [polypeptide binding]; other site 1166130011346 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1166130011347 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1166130011348 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1166130011349 active site 1166130011350 Riboflavin kinase; Region: Flavokinase; smart00904 1166130011351 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1166130011352 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1166130011353 active site 1166130011354 HIGH motif; other site 1166130011355 nucleotide binding site [chemical binding]; other site 1166130011356 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1166130011357 active site 1166130011358 KMSKS motif; other site 1166130011359 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1166130011360 tRNA binding surface [nucleotide binding]; other site 1166130011361 anticodon binding site; other site 1166130011362 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1166130011363 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1166130011364 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1166130011365 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1166130011366 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1166130011367 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1166130011368 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1166130011369 active site 1166130011370 tetramer interface [polypeptide binding]; other site 1166130011371 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1166130011372 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1166130011373 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1166130011374 carbamoyl-phosphate synthase, small subunit; Region: CPSaseIIsmall; TIGR01368 1166130011375 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1166130011376 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1166130011377 catalytic site [active] 1166130011378 subunit interface [polypeptide binding]; other site 1166130011379 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1166130011380 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1166130011381 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1166130011382 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1166130011383 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1166130011384 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1166130011385 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1166130011386 IMP binding site; other site 1166130011387 dimer interface [polypeptide binding]; other site 1166130011388 interdomain contacts; other site 1166130011389 partial ornithine binding site; other site 1166130011390 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1166130011391 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 1166130011392 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1166130011393 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 1166130011394 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1166130011395 TrkA-N domain; Region: TrkA_N; pfam02254 1166130011396 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1166130011397 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1166130011398 folate binding site [chemical binding]; other site 1166130011399 NADP+ binding site [chemical binding]; other site 1166130011400 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 1166130011401 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1166130011402 active site 1166130011403 metal binding site [ion binding]; metal-binding site 1166130011404 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 1166130011405 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1166130011406 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1166130011407 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 1166130011408 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1166130011409 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 1166130011410 SurA N-terminal domain; Region: SurA_N; pfam09312 1166130011411 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1166130011412 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1166130011413 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 1166130011414 OstA-like protein; Region: OstA; pfam03968 1166130011415 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1166130011416 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 1166130011417 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 1166130011418 putative metal binding site [ion binding]; other site 1166130011419 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1166130011420 HSP70 interaction site [polypeptide binding]; other site 1166130011421 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1166130011422 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1166130011423 active site 1166130011424 ATP-dependent helicase HepA; Validated; Region: PRK04914 1166130011425 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1166130011426 ATP binding site [chemical binding]; other site 1166130011427 putative Mg++ binding site [ion binding]; other site 1166130011428 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1166130011429 nucleotide binding region [chemical binding]; other site 1166130011430 ATP-binding site [chemical binding]; other site 1166130011431 DNA polymerase II; Reviewed; Region: PRK05762 1166130011432 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 1166130011433 active site 1166130011434 catalytic site [active] 1166130011435 substrate binding site [chemical binding]; other site 1166130011436 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 1166130011437 active site 1166130011438 metal-binding site 1166130011439 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1166130011440 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1166130011441 intersubunit interface [polypeptide binding]; other site 1166130011442 active site 1166130011443 Zn2+ binding site [ion binding]; other site 1166130011444 L-arabinose isomerase; Provisional; Region: PRK02929 1166130011445 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1166130011446 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1166130011447 trimer interface [polypeptide binding]; other site 1166130011448 putative substrate binding site [chemical binding]; other site 1166130011449 putative metal binding site [ion binding]; other site 1166130011450 ribulokinase; Provisional; Region: PRK04123 1166130011451 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1166130011452 N- and C-terminal domain interface [polypeptide binding]; other site 1166130011453 active site 1166130011454 MgATP binding site [chemical binding]; other site 1166130011455 catalytic site [active] 1166130011456 metal binding site [ion binding]; metal-binding site 1166130011457 carbohydrate binding site [chemical binding]; other site 1166130011458 homodimer interface [polypeptide binding]; other site 1166130011459 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 1166130011460 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1166130011461 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130011462 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130011463 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1166130011464 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1166130011465 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 1166130011466 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 1166130011467 Walker A/P-loop; other site 1166130011468 ATP binding site [chemical binding]; other site 1166130011469 Q-loop/lid; other site 1166130011470 ABC transporter signature motif; other site 1166130011471 Walker B; other site 1166130011472 D-loop; other site 1166130011473 H-loop/switch region; other site 1166130011474 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 1166130011475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130011476 dimer interface [polypeptide binding]; other site 1166130011477 conserved gate region; other site 1166130011478 putative PBP binding loops; other site 1166130011479 ABC-ATPase subunit interface; other site 1166130011480 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130011481 dimer interface [polypeptide binding]; other site 1166130011482 conserved gate region; other site 1166130011483 putative PBP binding loops; other site 1166130011484 ABC-ATPase subunit interface; other site 1166130011485 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1166130011486 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 1166130011487 transcriptional regulator SgrR; Provisional; Region: PRK13626 1166130011488 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1166130011489 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 1166130011490 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130011491 sugar efflux transporter; Region: 2A0120; TIGR00899 1166130011492 putative substrate translocation pore; other site 1166130011493 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1166130011494 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1166130011495 substrate binding site [chemical binding]; other site 1166130011496 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1166130011497 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1166130011498 substrate binding site [chemical binding]; other site 1166130011499 ligand binding site [chemical binding]; other site 1166130011500 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1166130011501 tartrate dehydrogenase; Region: TTC; TIGR02089 1166130011502 2-isopropylmalate synthase; Validated; Region: PRK00915 1166130011503 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1166130011504 active site 1166130011505 catalytic residues [active] 1166130011506 metal binding site [ion binding]; metal-binding site 1166130011507 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1166130011508 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 1166130011509 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130011510 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 1166130011511 putative substrate binding pocket [chemical binding]; other site 1166130011512 putative dimerization interface [polypeptide binding]; other site 1166130011513 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 1166130011514 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1166130011515 PYR/PP interface [polypeptide binding]; other site 1166130011516 dimer interface [polypeptide binding]; other site 1166130011517 TPP binding site [chemical binding]; other site 1166130011518 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1166130011519 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1166130011520 TPP-binding site [chemical binding]; other site 1166130011521 dimer interface [polypeptide binding]; other site 1166130011522 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1166130011523 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1166130011524 putative valine binding site [chemical binding]; other site 1166130011525 dimer interface [polypeptide binding]; other site 1166130011526 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1166130011527 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 1166130011528 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1166130011529 DNA binding site [nucleotide binding] 1166130011530 domain linker motif; other site 1166130011531 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1166130011532 dimerization interface [polypeptide binding]; other site 1166130011533 ligand binding site [chemical binding]; other site 1166130011534 MraZ protein; Region: MraZ; pfam02381 1166130011535 MraZ protein; Region: MraZ; pfam02381 1166130011536 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 1166130011537 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1166130011538 cell division protein FtsL; Provisional; Region: PRK10772 1166130011539 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 1166130011540 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1166130011541 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1166130011542 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1166130011543 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1166130011544 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1166130011545 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1166130011546 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 1166130011547 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1166130011548 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1166130011549 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1166130011550 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1166130011551 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1166130011552 Mg++ binding site [ion binding]; other site 1166130011553 putative catalytic motif [active] 1166130011554 putative substrate binding site [chemical binding]; other site 1166130011555 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 1166130011556 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1166130011557 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1166130011558 cell division protein FtsW; Provisional; Region: PRK10774 1166130011559 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1166130011560 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1166130011561 active site 1166130011562 homodimer interface [polypeptide binding]; other site 1166130011563 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1166130011564 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1166130011565 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1166130011566 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1166130011567 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1166130011568 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1166130011569 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1166130011570 cell division protein FtsQ; Provisional; Region: PRK10775 1166130011571 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1166130011572 Cell division protein FtsQ; Region: FtsQ; pfam03799 1166130011573 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 1166130011574 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1166130011575 Cell division protein FtsA; Region: FtsA; pfam14450 1166130011576 cell division protein FtsZ; Validated; Region: PRK09330 1166130011577 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1166130011578 nucleotide binding site [chemical binding]; other site 1166130011579 SulA interaction site; other site 1166130011580 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1166130011581 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1166130011582 SecA regulator SecM; Provisional; Region: PRK02943 1166130011583 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1166130011584 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1166130011585 SEC-C motif; Region: SEC-C; pfam02810 1166130011586 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1166130011587 active site 1166130011588 8-oxo-dGMP binding site [chemical binding]; other site 1166130011589 nudix motif; other site 1166130011590 metal binding site [ion binding]; metal-binding site 1166130011591 DNA gyrase inhibitor; Reviewed; Region: PRK00418 1166130011592 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 1166130011593 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1166130011594 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1166130011595 CoA-binding site [chemical binding]; other site 1166130011596 ATP-binding [chemical binding]; other site 1166130011597 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 1166130011598 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1166130011599 active site 1166130011600 type IV pilin biogenesis protein; Provisional; Region: PRK10573 1166130011601 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1166130011602 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1166130011603 hypothetical protein; Provisional; Region: PRK10436 1166130011604 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1166130011605 Walker A motif; other site 1166130011606 ATP binding site [chemical binding]; other site 1166130011607 Walker B motif; other site 1166130011608 putative major pilin subunit; Provisional; Region: PRK10574 1166130011609 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1166130011610 Pilin (bacterial filament); Region: Pilin; pfam00114 1166130011611 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 1166130011612 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1166130011613 dimerization interface [polypeptide binding]; other site 1166130011614 active site 1166130011615 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1166130011616 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1166130011617 amidase catalytic site [active] 1166130011618 Zn binding residues [ion binding]; other site 1166130011619 substrate binding site [chemical binding]; other site 1166130011620 regulatory protein AmpE; Provisional; Region: PRK10987 1166130011621 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 1166130011622 active site 1166130011623 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1166130011624 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130011625 putative substrate translocation pore; other site 1166130011626 aromatic amino acid transporter; Provisional; Region: PRK10238 1166130011627 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 1166130011628 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166130011629 DNA-binding site [nucleotide binding]; DNA binding site 1166130011630 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1166130011631 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1166130011632 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1166130011633 dimer interface [polypeptide binding]; other site 1166130011634 TPP-binding site [chemical binding]; other site 1166130011635 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 1166130011636 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1166130011637 E3 interaction surface; other site 1166130011638 lipoyl attachment site [posttranslational modification]; other site 1166130011639 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1166130011640 E3 interaction surface; other site 1166130011641 lipoyl attachment site [posttranslational modification]; other site 1166130011642 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1166130011643 E3 interaction surface; other site 1166130011644 lipoyl attachment site [posttranslational modification]; other site 1166130011645 e3 binding domain; Region: E3_binding; pfam02817 1166130011646 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1166130011647 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1166130011648 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1166130011649 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1166130011650 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1166130011651 conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731 1166130011652 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 1166130011653 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1166130011654 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1166130011655 substrate binding site [chemical binding]; other site 1166130011656 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1166130011657 substrate binding site [chemical binding]; other site 1166130011658 ligand binding site [chemical binding]; other site 1166130011659 hypothetical protein; Provisional; Region: PRK05248 1166130011660 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 1166130011661 spermidine synthase; Provisional; Region: PRK00811 1166130011662 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166130011663 S-adenosylmethionine binding site [chemical binding]; other site 1166130011664 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 1166130011665 multicopper oxidase; Provisional; Region: PRK10965 1166130011666 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1166130011667 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1166130011668 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1166130011669 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1166130011670 Trp docking motif [polypeptide binding]; other site 1166130011671 putative active site [active] 1166130011672 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1166130011673 active site 1166130011674 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1166130011675 active site clefts [active] 1166130011676 zinc binding site [ion binding]; other site 1166130011677 dimer interface [polypeptide binding]; other site 1166130011678 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1166130011679 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1166130011680 Walker A/P-loop; other site 1166130011681 ATP binding site [chemical binding]; other site 1166130011682 Q-loop/lid; other site 1166130011683 ABC transporter signature motif; other site 1166130011684 Walker B; other site 1166130011685 D-loop; other site 1166130011686 H-loop/switch region; other site 1166130011687 inner membrane transport permease; Provisional; Region: PRK15066 1166130011688 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1166130011689 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1166130011690 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 1166130011691 putative active site [active] 1166130011692 putative metal binding site [ion binding]; other site 1166130011693 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1166130011694 tetramerization interface [polypeptide binding]; other site 1166130011695 active site 1166130011696 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1166130011697 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1166130011698 active site 1166130011699 ATP-binding site [chemical binding]; other site 1166130011700 pantoate-binding site; other site 1166130011701 HXXH motif; other site 1166130011702 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1166130011703 active site 1166130011704 oligomerization interface [polypeptide binding]; other site 1166130011705 metal binding site [ion binding]; metal-binding site 1166130011706 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1166130011707 catalytic center binding site [active] 1166130011708 ATP binding site [chemical binding]; other site 1166130011709 poly(A) polymerase; Region: pcnB; TIGR01942 1166130011710 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1166130011711 active site 1166130011712 NTP binding site [chemical binding]; other site 1166130011713 metal binding triad [ion binding]; metal-binding site 1166130011714 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1166130011715 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 1166130011716 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 1166130011717 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1166130011718 2'-5' RNA ligase; Provisional; Region: PRK15124 1166130011719 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1166130011720 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1166130011721 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 1166130011722 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1166130011723 ATP binding site [chemical binding]; other site 1166130011724 putative Mg++ binding site [ion binding]; other site 1166130011725 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1166130011726 nucleotide binding region [chemical binding]; other site 1166130011727 ATP-binding site [chemical binding]; other site 1166130011728 Helicase associated domain (HA2); Region: HA2; pfam04408 1166130011729 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1166130011730 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 1166130011731 Transglycosylase; Region: Transgly; pfam00912 1166130011732 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1166130011733 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1166130011734 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1166130011735 N-terminal plug; other site 1166130011736 ligand-binding site [chemical binding]; other site 1166130011737 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 1166130011738 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1166130011739 Walker A/P-loop; other site 1166130011740 ATP binding site [chemical binding]; other site 1166130011741 Q-loop/lid; other site 1166130011742 ABC transporter signature motif; other site 1166130011743 Walker B; other site 1166130011744 D-loop; other site 1166130011745 H-loop/switch region; other site 1166130011746 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1166130011747 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1166130011748 siderophore binding site; other site 1166130011749 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1166130011750 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1166130011751 ABC-ATPase subunit interface; other site 1166130011752 dimer interface [polypeptide binding]; other site 1166130011753 putative PBP binding regions; other site 1166130011754 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1166130011755 ABC-ATPase subunit interface; other site 1166130011756 dimer interface [polypeptide binding]; other site 1166130011757 putative PBP binding regions; other site 1166130011758 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1166130011759 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1166130011760 inhibitor-cofactor binding pocket; inhibition site 1166130011761 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130011762 catalytic residue [active] 1166130011763 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1166130011764 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1166130011765 Cl- selectivity filter; other site 1166130011766 Cl- binding residues [ion binding]; other site 1166130011767 pore gating glutamate residue; other site 1166130011768 dimer interface [polypeptide binding]; other site 1166130011769 H+/Cl- coupling transport residue; other site 1166130011770 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1166130011771 hypothetical protein; Provisional; Region: PRK10578 1166130011772 UPF0126 domain; Region: UPF0126; pfam03458 1166130011773 UPF0126 domain; Region: UPF0126; pfam03458 1166130011774 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 1166130011775 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1166130011776 cobalamin binding residues [chemical binding]; other site 1166130011777 putative BtuC binding residues; other site 1166130011778 dimer interface [polypeptide binding]; other site 1166130011779 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1166130011780 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1166130011781 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 1166130011782 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1166130011783 Zn2+ binding site [ion binding]; other site 1166130011784 Mg2+ binding site [ion binding]; other site 1166130011785 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1166130011786 serine endoprotease; Provisional; Region: PRK10942 1166130011787 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1166130011788 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1166130011789 protein binding site [polypeptide binding]; other site 1166130011790 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1166130011791 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 1166130011792 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1166130011793 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1166130011794 hypothetical protein; Provisional; Region: PRK13677 1166130011795 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1166130011796 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1166130011797 trimer interface [polypeptide binding]; other site 1166130011798 active site 1166130011799 substrate binding site [chemical binding]; other site 1166130011800 CoA binding site [chemical binding]; other site 1166130011801 PII uridylyl-transferase; Provisional; Region: PRK05007 1166130011802 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1166130011803 metal binding triad; other site 1166130011804 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1166130011805 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1166130011806 Zn2+ binding site [ion binding]; other site 1166130011807 Mg2+ binding site [ion binding]; other site 1166130011808 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1166130011809 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1166130011810 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1166130011811 active site 1166130011812 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1166130011813 rRNA interaction site [nucleotide binding]; other site 1166130011814 S8 interaction site; other site 1166130011815 putative laminin-1 binding site; other site 1166130011816 elongation factor Ts; Provisional; Region: tsf; PRK09377 1166130011817 UBA/TS-N domain; Region: UBA; pfam00627 1166130011818 Elongation factor TS; Region: EF_TS; pfam00889 1166130011819 Elongation factor TS; Region: EF_TS; pfam00889 1166130011820 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1166130011821 putative nucleotide binding site [chemical binding]; other site 1166130011822 uridine monophosphate binding site [chemical binding]; other site 1166130011823 homohexameric interface [polypeptide binding]; other site 1166130011824 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1166130011825 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1166130011826 hinge region; other site 1166130011827 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1166130011828 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1166130011829 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1166130011830 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1166130011831 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1166130011832 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1166130011833 catalytic residue [active] 1166130011834 putative FPP diphosphate binding site; other site 1166130011835 putative FPP binding hydrophobic cleft; other site 1166130011836 dimer interface [polypeptide binding]; other site 1166130011837 putative IPP diphosphate binding site; other site 1166130011838 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 1166130011839 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1166130011840 zinc metallopeptidase RseP; Provisional; Region: PRK10779 1166130011841 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1166130011842 active site 1166130011843 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1166130011844 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1166130011845 protein binding site [polypeptide binding]; other site 1166130011846 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1166130011847 putative substrate binding region [chemical binding]; other site 1166130011848 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 1166130011849 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1166130011850 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1166130011851 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1166130011852 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1166130011853 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1166130011854 Surface antigen; Region: Bac_surface_Ag; pfam01103 1166130011855 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1166130011856 periplasmic chaperone; Provisional; Region: PRK10780 1166130011857 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1166130011858 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1166130011859 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1166130011860 trimer interface [polypeptide binding]; other site 1166130011861 active site 1166130011862 UDP-GlcNAc binding site [chemical binding]; other site 1166130011863 lipid binding site [chemical binding]; lipid-binding site 1166130011864 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1166130011865 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1166130011866 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1166130011867 active site 1166130011868 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1166130011869 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1166130011870 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1166130011871 RNA/DNA hybrid binding site [nucleotide binding]; other site 1166130011872 active site 1166130011873 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1166130011874 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1166130011875 putative active site [active] 1166130011876 putative PHP Thumb interface [polypeptide binding]; other site 1166130011877 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1166130011878 generic binding surface II; other site 1166130011879 generic binding surface I; other site 1166130011880 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1166130011881 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1166130011882 lysine decarboxylase LdcC; Provisional; Region: PRK15399 1166130011883 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1166130011884 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1166130011885 homodimer interface [polypeptide binding]; other site 1166130011886 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130011887 catalytic residue [active] 1166130011888 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1166130011889 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1166130011890 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1166130011891 putative metal binding site [ion binding]; other site 1166130011892 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 1166130011893 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1166130011894 Ligand Binding Site [chemical binding]; other site 1166130011895 TilS substrate binding domain; Region: TilS; pfam09179 1166130011896 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 1166130011897 Rho-binding antiterminator; Provisional; Region: PRK11625 1166130011898 hypothetical protein; Provisional; Region: PRK04964 1166130011899 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 1166130011900 hypothetical protein; Provisional; Region: PRK09256 1166130011901 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1166130011902 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 1166130011903 NlpE N-terminal domain; Region: NlpE; pfam04170 1166130011904 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1166130011905 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1166130011906 dimer interface [polypeptide binding]; other site 1166130011907 motif 1; other site 1166130011908 active site 1166130011909 motif 2; other site 1166130011910 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1166130011911 putative deacylase active site [active] 1166130011912 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1166130011913 active site 1166130011914 motif 3; other site 1166130011915 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1166130011916 anticodon binding site; other site 1166130011917 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1166130011918 homodimer interaction site [polypeptide binding]; other site 1166130011919 cofactor binding site; other site 1166130011920 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 1166130011921 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 1166130011922 lipoprotein, YaeC family; Region: TIGR00363 1166130011923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130011924 dimer interface [polypeptide binding]; other site 1166130011925 conserved gate region; other site 1166130011926 ABC-ATPase subunit interface; other site 1166130011927 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1166130011928 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1166130011929 Walker A/P-loop; other site 1166130011930 ATP binding site [chemical binding]; other site 1166130011931 Q-loop/lid; other site 1166130011932 ABC transporter signature motif; other site 1166130011933 Walker B; other site 1166130011934 D-loop; other site 1166130011935 H-loop/switch region; other site 1166130011936 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1166130011937 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 1166130011938 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1166130011939 active site 1166130011940 motif I; other site 1166130011941 motif II; other site 1166130011942 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1166130011943 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 1166130011944 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1166130011945 active site 1166130011946 motif I; other site 1166130011947 motif II; other site 1166130011948 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 1166130011949 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1166130011950 dimer interface [polypeptide binding]; other site 1166130011951 active site 1166130011952 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1166130011953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130011954 putative substrate translocation pore; other site 1166130011955 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1166130011956 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1166130011957 HlyD family secretion protein; Region: HlyD_3; pfam13437 1166130011958 Predicted transcriptional regulators [Transcription]; Region: COG1733 1166130011959 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1166130011960 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1166130011961 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1166130011962 active site 1166130011963 catalytic tetrad [active] 1166130011964 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166130011965 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130011966 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 1166130011967 putative effector binding pocket; other site 1166130011968 dimerization interface [polypeptide binding]; other site 1166130011969 hypothetical protein; Provisional; Region: PRK05421 1166130011970 putative catalytic site [active] 1166130011971 putative metal binding site [ion binding]; other site 1166130011972 putative phosphate binding site [ion binding]; other site 1166130011973 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1166130011974 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1166130011975 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1166130011976 catalytic residue [active] 1166130011977 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1166130011978 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1166130011979 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1166130011980 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1166130011981 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 1166130011982 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1166130011983 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1166130011984 RNA/DNA hybrid binding site [nucleotide binding]; other site 1166130011985 active site 1166130011986 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1166130011987 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1166130011988 active site 1166130011989 catalytic site [active] 1166130011990 substrate binding site [chemical binding]; other site 1166130011991 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 1166130011992 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1166130011993 Na binding site [ion binding]; other site 1166130011994 putative substrate binding site [chemical binding]; other site 1166130011995 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1166130011996 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166130011997 DNA-binding site [nucleotide binding]; DNA binding site 1166130011998 FCD domain; Region: FCD; pfam07729 1166130011999 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 1166130012000 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1166130012001 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 1166130012002 active site 1166130012003 catalytic site [active] 1166130012004 tetramer interface [polypeptide binding]; other site 1166130012005 flap endonuclease-like protein; Provisional; Region: PRK09482 1166130012006 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1166130012007 active site 1166130012008 metal binding site 1 [ion binding]; metal-binding site 1166130012009 putative 5' ssDNA interaction site; other site 1166130012010 metal binding site 3; metal-binding site 1166130012011 metal binding site 2 [ion binding]; metal-binding site 1166130012012 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1166130012013 putative DNA binding site [nucleotide binding]; other site 1166130012014 putative metal binding site [ion binding]; other site 1166130012015 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1166130012016 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1166130012017 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1166130012018 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1166130012019 serine transporter; Region: stp; TIGR00814 1166130012020 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1166130012021 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 1166130012022 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 1166130012023 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 1166130012024 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1166130012025 SecY interacting protein Syd; Provisional; Region: PRK04968 1166130012026 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 1166130012027 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 1166130012028 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1166130012029 probable active site [active] 1166130012030 flavodoxin; Provisional; Region: PRK08105 1166130012031 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130012032 D-galactonate transporter; Region: 2A0114; TIGR00893 1166130012033 putative substrate translocation pore; other site 1166130012034 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1166130012035 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1166130012036 active site 1166130012037 tetramer interface [polypeptide binding]; other site 1166130012038 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1166130012039 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1166130012040 active site 1166130012041 tetramer interface [polypeptide binding]; other site 1166130012042 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1166130012043 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 1166130012044 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 1166130012045 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166130012046 dimerization interface [polypeptide binding]; other site 1166130012047 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1166130012048 dimer interface [polypeptide binding]; other site 1166130012049 phosphorylation site [posttranslational modification] 1166130012050 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166130012051 ATP binding site [chemical binding]; other site 1166130012052 Mg2+ binding site [ion binding]; other site 1166130012053 G-X-G motif; other site 1166130012054 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 1166130012055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130012056 active site 1166130012057 phosphorylation site [posttranslational modification] 1166130012058 intermolecular recognition site; other site 1166130012059 dimerization interface [polypeptide binding]; other site 1166130012060 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1166130012061 putative binding surface; other site 1166130012062 active site 1166130012063 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 1166130012064 TRAM domain; Region: TRAM; pfam01938 1166130012065 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166130012066 S-adenosylmethionine binding site [chemical binding]; other site 1166130012067 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 1166130012068 HD domain; Region: HD_4; pfam13328 1166130012069 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1166130012070 synthetase active site [active] 1166130012071 NTP binding site [chemical binding]; other site 1166130012072 metal binding site [ion binding]; metal-binding site 1166130012073 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1166130012074 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1166130012075 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1166130012076 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1166130012077 homodimer interface [polypeptide binding]; other site 1166130012078 metal binding site [ion binding]; metal-binding site 1166130012079 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1166130012080 homodimer interface [polypeptide binding]; other site 1166130012081 active site 1166130012082 putative chemical substrate binding site [chemical binding]; other site 1166130012083 metal binding site [ion binding]; metal-binding site 1166130012084 CTP synthetase; Validated; Region: pyrG; PRK05380 1166130012085 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1166130012086 Catalytic site [active] 1166130012087 active site 1166130012088 UTP binding site [chemical binding]; other site 1166130012089 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1166130012090 active site 1166130012091 putative oxyanion hole; other site 1166130012092 catalytic triad [active] 1166130012093 enolase; Provisional; Region: eno; PRK00077 1166130012094 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1166130012095 dimer interface [polypeptide binding]; other site 1166130012096 metal binding site [ion binding]; metal-binding site 1166130012097 substrate binding pocket [chemical binding]; other site 1166130012098 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1166130012099 NAD(P) binding site [chemical binding]; other site 1166130012100 active site 1166130012101 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1166130012102 Repair protein; Region: Repair_PSII; pfam04536 1166130012103 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 1166130012104 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1166130012105 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 1166130012106 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1166130012107 NADP binding site [chemical binding]; other site 1166130012108 homodimer interface [polypeptide binding]; other site 1166130012109 active site 1166130012110 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1166130012111 active site 1166130012112 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 1166130012113 Flavodoxin; Region: Flavodoxin_1; pfam00258 1166130012114 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1166130012115 FAD binding pocket [chemical binding]; other site 1166130012116 FAD binding motif [chemical binding]; other site 1166130012117 catalytic residues [active] 1166130012118 NAD binding pocket [chemical binding]; other site 1166130012119 phosphate binding motif [ion binding]; other site 1166130012120 beta-alpha-beta structure motif; other site 1166130012121 sulfite reductase subunit beta; Provisional; Region: PRK13504 1166130012122 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1166130012123 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1166130012124 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1166130012125 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1166130012126 Active Sites [active] 1166130012127 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 1166130012128 SnoaL-like domain; Region: SnoaL_3; pfam13474 1166130012129 amidase; Provisional; Region: PRK09201 1166130012130 Amidase; Region: Amidase; cl11426 1166130012131 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 1166130012132 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1166130012133 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1166130012134 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1166130012135 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1166130012136 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1166130012137 putative active site [active] 1166130012138 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1166130012139 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1166130012140 catalytic residue [active] 1166130012141 allantoate amidohydrolase; Reviewed; Region: PRK09290 1166130012142 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1166130012143 active site 1166130012144 metal binding site [ion binding]; metal-binding site 1166130012145 dimer interface [polypeptide binding]; other site 1166130012146 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1166130012147 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166130012148 DNA-binding site [nucleotide binding]; DNA binding site 1166130012149 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1166130012150 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1166130012151 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1166130012152 Walker A/P-loop; other site 1166130012153 ATP binding site [chemical binding]; other site 1166130012154 Q-loop/lid; other site 1166130012155 ABC transporter signature motif; other site 1166130012156 Walker B; other site 1166130012157 D-loop; other site 1166130012158 H-loop/switch region; other site 1166130012159 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1166130012160 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1166130012161 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1166130012162 Walker A/P-loop; other site 1166130012163 ATP binding site [chemical binding]; other site 1166130012164 Q-loop/lid; other site 1166130012165 ABC transporter signature motif; other site 1166130012166 Walker B; other site 1166130012167 D-loop; other site 1166130012168 H-loop/switch region; other site 1166130012169 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1166130012170 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1166130012171 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511 1166130012172 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1166130012173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130012174 dimer interface [polypeptide binding]; other site 1166130012175 conserved gate region; other site 1166130012176 ABC-ATPase subunit interface; other site 1166130012177 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1166130012178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130012179 dimer interface [polypeptide binding]; other site 1166130012180 conserved gate region; other site 1166130012181 putative PBP binding loops; other site 1166130012182 ABC-ATPase subunit interface; other site 1166130012183 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1166130012184 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1166130012185 C-N hydrolase family amidase; Provisional; Region: PRK10438 1166130012186 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 1166130012187 putative active site [active] 1166130012188 catalytic triad [active] 1166130012189 dimer interface [polypeptide binding]; other site 1166130012190 multimer interface [polypeptide binding]; other site 1166130012191 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 1166130012192 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1166130012193 active site 1166130012194 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 1166130012195 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1166130012196 dimer interface [polypeptide binding]; other site 1166130012197 active site 1166130012198 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1166130012199 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1166130012200 putative active site [active] 1166130012201 putative dimer interface [polypeptide binding]; other site 1166130012202 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 1166130012203 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1166130012204 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1166130012205 active site 1166130012206 DNA polymerase IV; Validated; Region: PRK02406 1166130012207 DNA binding site [nucleotide binding] 1166130012208 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 1166130012209 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 1166130012210 metal binding site [ion binding]; metal-binding site 1166130012211 dimer interface [polypeptide binding]; other site 1166130012212 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1166130012213 active site 1166130012214 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 1166130012215 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 1166130012216 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1166130012217 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1166130012218 trimer interface [polypeptide binding]; other site 1166130012219 eyelet of channel; other site 1166130012220 gamma-glutamyl kinase; Provisional; Region: PRK05429 1166130012221 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1166130012222 nucleotide binding site [chemical binding]; other site 1166130012223 homotetrameric interface [polypeptide binding]; other site 1166130012224 putative phosphate binding site [ion binding]; other site 1166130012225 putative allosteric binding site; other site 1166130012226 PUA domain; Region: PUA; pfam01472 1166130012227 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1166130012228 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1166130012229 putative catalytic cysteine [active] 1166130012230 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1166130012231 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1166130012232 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1166130012233 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1166130012234 zinc/cadmium-binding protein; Provisional; Region: PRK10306 1166130012235 hypothetical protein; Provisional; Region: PRK11469 1166130012236 Domain of unknown function DUF; Region: DUF204; pfam02659 1166130012237 Domain of unknown function DUF; Region: DUF204; pfam02659 1166130012238 chromosome condensation membrane protein; Provisional; Region: PRK14196 1166130012239 General stress protein [General function prediction only]; Region: GsiB; COG3729 1166130012240 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166130012241 D-loop; other site 1166130012242 H-loop/switch region; other site 1166130012243 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130012244 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1166130012245 dimerization interface [polypeptide binding]; other site 1166130012246 Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen; Region: GT8_Glycogenin; cd02537 1166130012247 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1166130012248 substrate binding site; other site 1166130012249 Manganese binding site; other site 1166130012250 dimer interface; other site 1166130012251 sugar 1,4-lactone oxidases; Region: FAD_lactone_ox; TIGR01678 1166130012252 FAD binding domain; Region: FAD_binding_4; pfam01565 1166130012253 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1166130012254 Competence-damaged protein; Region: CinA; cl00666 1166130012255 Predicted membrane protein [Function unknown]; Region: COG2323 1166130012256 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 1166130012257 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 1166130012258 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1166130012259 ethanolamine permease; Region: 2A0305; TIGR00908 1166130012260 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 1166130012261 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1166130012262 putative acyl-acceptor binding pocket; other site 1166130012263 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 1166130012264 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1166130012265 dimer interface [polypeptide binding]; other site 1166130012266 active site 1166130012267 Schiff base residues; other site 1166130012268 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 1166130012269 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1166130012270 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1166130012271 Isochorismatase family; Region: Isochorismatase; pfam00857 1166130012272 catalytic triad [active] 1166130012273 conserved cis-peptide bond; other site 1166130012274 microcin B17 transporter; Reviewed; Region: PRK11098 1166130012275 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 1166130012276 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 1166130012277 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 1166130012278 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1166130012279 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1166130012280 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1166130012281 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 1166130012282 drug efflux system protein MdtG; Provisional; Region: PRK09874 1166130012283 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130012284 putative substrate translocation pore; other site 1166130012285 Sigma-S stabilisation anti-adaptor protein; Region: Anti-adapt_IraP; cl11681 1166130012286 alkaline phosphatase; Provisional; Region: PRK10518 1166130012287 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1166130012288 dimer interface [polypeptide binding]; other site 1166130012289 active site 1166130012290 psiF repeat; Region: PsiF_repeat; pfam07769 1166130012291 psiF repeat; Region: PsiF_repeat; pfam07769 1166130012292 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1166130012293 iron-sulfur cluster [ion binding]; other site 1166130012294 [2Fe-2S] cluster binding site [ion binding]; other site 1166130012295 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1166130012296 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1166130012297 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1166130012298 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1166130012299 pyrroline-5-carboxylate reductase; Region: PLN02688 1166130012300 hypothetical protein; Validated; Region: PRK00124 1166130012301 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 1166130012302 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1166130012303 ADP binding site [chemical binding]; other site 1166130012304 magnesium binding site [ion binding]; other site 1166130012305 putative shikimate binding site; other site 1166130012306 hypothetical protein; Provisional; Region: PRK10380 1166130012307 hypothetical protein; Provisional; Region: PRK10481 1166130012308 hypothetical protein; Provisional; Region: PRK10579 1166130012309 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 1166130012310 fructokinase; Reviewed; Region: PRK09557 1166130012311 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1166130012312 nucleotide binding site [chemical binding]; other site 1166130012313 exonuclease subunit SbcC; Provisional; Region: PRK10246 1166130012314 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166130012315 Walker A/P-loop; other site 1166130012316 ATP binding site [chemical binding]; other site 1166130012317 Q-loop/lid; other site 1166130012318 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166130012319 ABC transporter signature motif; other site 1166130012320 Walker B; other site 1166130012321 D-loop; other site 1166130012322 H-loop/switch region; other site 1166130012323 exonuclease subunit SbcD; Provisional; Region: PRK10966 1166130012324 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1166130012325 active site 1166130012326 metal binding site [ion binding]; metal-binding site 1166130012327 DNA binding site [nucleotide binding] 1166130012328 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1166130012329 transcriptional regulator PhoB; Provisional; Region: PRK10161 1166130012330 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130012331 active site 1166130012332 phosphorylation site [posttranslational modification] 1166130012333 intermolecular recognition site; other site 1166130012334 dimerization interface [polypeptide binding]; other site 1166130012335 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1166130012336 DNA binding site [nucleotide binding] 1166130012337 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 1166130012338 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 1166130012339 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1166130012340 putative active site [active] 1166130012341 heme pocket [chemical binding]; other site 1166130012342 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1166130012343 dimer interface [polypeptide binding]; other site 1166130012344 phosphorylation site [posttranslational modification] 1166130012345 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166130012346 ATP binding site [chemical binding]; other site 1166130012347 Mg2+ binding site [ion binding]; other site 1166130012348 G-X-G motif; other site 1166130012349 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1166130012350 putative proline-specific permease; Provisional; Region: proY; PRK10580 1166130012351 Spore germination protein; Region: Spore_permease; cl17796 1166130012352 maltodextrin glucosidase; Provisional; Region: PRK10785 1166130012353 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1166130012354 homodimer interface [polypeptide binding]; other site 1166130012355 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1166130012356 active site 1166130012357 homodimer interface [polypeptide binding]; other site 1166130012358 catalytic site [active] 1166130012359 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 1166130012360 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 1166130012361 peroxidase; Provisional; Region: PRK15000 1166130012362 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1166130012363 dimer interface [polypeptide binding]; other site 1166130012364 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1166130012365 catalytic triad [active] 1166130012366 peroxidatic and resolving cysteines [active] 1166130012367 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 1166130012368 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1166130012369 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1166130012370 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1166130012371 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 1166130012372 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1166130012373 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 1166130012374 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1166130012375 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1166130012376 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1166130012377 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1166130012378 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1166130012379 Protein export membrane protein; Region: SecD_SecF; pfam02355 1166130012380 transcriptional regulator RcsB; Provisional; Region: PRK10840 1166130012381 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130012382 active site 1166130012383 phosphorylation site [posttranslational modification] 1166130012384 intermolecular recognition site; other site 1166130012385 dimerization interface [polypeptide binding]; other site 1166130012386 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1166130012387 DNA binding residues [nucleotide binding] 1166130012388 dimerization interface [polypeptide binding]; other site 1166130012389 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 1166130012390 PAS fold; Region: PAS_4; pfam08448 1166130012391 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1166130012392 dimer interface [polypeptide binding]; other site 1166130012393 phosphorylation site [posttranslational modification] 1166130012394 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1166130012395 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166130012396 ATP binding site [chemical binding]; other site 1166130012397 Mg2+ binding site [ion binding]; other site 1166130012398 G-X-G motif; other site 1166130012399 Response regulator receiver domain; Region: Response_reg; pfam00072 1166130012400 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130012401 active site 1166130012402 phosphorylation site [posttranslational modification] 1166130012403 intermolecular recognition site; other site 1166130012404 dimerization interface [polypeptide binding]; other site 1166130012405 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1166130012406 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130012407 active site 1166130012408 phosphorylation site [posttranslational modification] 1166130012409 intermolecular recognition site; other site 1166130012410 dimerization interface [polypeptide binding]; other site 1166130012411 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1166130012412 DNA binding residues [nucleotide binding] 1166130012413 dimerization interface [polypeptide binding]; other site 1166130012414 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1166130012415 FtsX-like permease family; Region: FtsX; pfam02687 1166130012416 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1166130012417 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1166130012418 Walker A/P-loop; other site 1166130012419 ATP binding site [chemical binding]; other site 1166130012420 Q-loop/lid; other site 1166130012421 ABC transporter signature motif; other site 1166130012422 Walker B; other site 1166130012423 D-loop; other site 1166130012424 H-loop/switch region; other site 1166130012425 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1166130012426 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1166130012427 Predicted transcriptional regulator [Transcription]; Region: COG2378 1166130012428 HTH domain; Region: HTH_11; pfam08279 1166130012429 WYL domain; Region: WYL; pfam13280 1166130012430 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 1166130012431 hypothetical protein; Provisional; Region: PRK11530 1166130012432 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1166130012433 ATP cone domain; Region: ATP-cone; pfam03477 1166130012434 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 1166130012435 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1166130012436 catalytic motif [active] 1166130012437 Zn binding site [ion binding]; other site 1166130012438 RibD C-terminal domain; Region: RibD_C; cl17279 1166130012439 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1166130012440 homopentamer interface [polypeptide binding]; other site 1166130012441 active site 1166130012442 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1166130012443 putative RNA binding site [nucleotide binding]; other site 1166130012444 thiamine monophosphate kinase; Provisional; Region: PRK05731 1166130012445 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1166130012446 ATP binding site [chemical binding]; other site 1166130012447 dimerization interface [polypeptide binding]; other site 1166130012448 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1166130012449 tetramer interfaces [polypeptide binding]; other site 1166130012450 binuclear metal-binding site [ion binding]; other site 1166130012451 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1166130012452 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1166130012453 active site 1166130012454 catalytic tetrad [active] 1166130012455 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1166130012456 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1166130012457 TPP-binding site; other site 1166130012458 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1166130012459 PYR/PP interface [polypeptide binding]; other site 1166130012460 dimer interface [polypeptide binding]; other site 1166130012461 TPP binding site [chemical binding]; other site 1166130012462 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1166130012463 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1166130012464 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1166130012465 substrate binding pocket [chemical binding]; other site 1166130012466 chain length determination region; other site 1166130012467 substrate-Mg2+ binding site; other site 1166130012468 catalytic residues [active] 1166130012469 aspartate-rich region 1; other site 1166130012470 active site lid residues [active] 1166130012471 aspartate-rich region 2; other site 1166130012472 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1166130012473 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 1166130012474 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1166130012475 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1166130012476 Ligand Binding Site [chemical binding]; other site 1166130012477 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1166130012478 active site residue [active] 1166130012479 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 1166130012480 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1166130012481 conserved cys residue [active] 1166130012482 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1166130012483 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1166130012484 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1166130012485 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1166130012486 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1166130012487 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130012488 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1166130012489 putative substrate translocation pore; other site 1166130012490 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 1166130012491 UbiA prenyltransferase family; Region: UbiA; pfam01040 1166130012492 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 1166130012493 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1166130012494 Subunit I/III interface [polypeptide binding]; other site 1166130012495 Subunit III/IV interface [polypeptide binding]; other site 1166130012496 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1166130012497 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1166130012498 D-pathway; other site 1166130012499 Putative ubiquinol binding site [chemical binding]; other site 1166130012500 Low-spin heme (heme b) binding site [chemical binding]; other site 1166130012501 Putative water exit pathway; other site 1166130012502 Binuclear center (heme o3/CuB) [ion binding]; other site 1166130012503 K-pathway; other site 1166130012504 Putative proton exit pathway; other site 1166130012505 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 1166130012506 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1166130012507 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1166130012508 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130012509 muropeptide transporter; Reviewed; Region: ampG; PRK11902 1166130012510 putative substrate translocation pore; other site 1166130012511 hypothetical protein; Provisional; Region: PRK11627 1166130012512 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1166130012513 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 1166130012514 transcriptional regulator BolA; Provisional; Region: PRK11628 1166130012515 trigger factor; Provisional; Region: tig; PRK01490 1166130012516 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1166130012517 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1166130012518 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1166130012519 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1166130012520 oligomer interface [polypeptide binding]; other site 1166130012521 active site residues [active] 1166130012522 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1166130012523 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1166130012524 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166130012525 Walker A motif; other site 1166130012526 ATP binding site [chemical binding]; other site 1166130012527 Walker B motif; other site 1166130012528 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1166130012529 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 1166130012530 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1166130012531 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1166130012532 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166130012533 Walker A motif; other site 1166130012534 ATP binding site [chemical binding]; other site 1166130012535 Walker B motif; other site 1166130012536 arginine finger; other site 1166130012537 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1166130012538 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1166130012539 IHF dimer interface [polypeptide binding]; other site 1166130012540 IHF - DNA interface [nucleotide binding]; other site 1166130012541 periplasmic folding chaperone; Provisional; Region: PRK10788 1166130012542 SurA N-terminal domain; Region: SurA_N_3; cl07813 1166130012543 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1166130012544 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 1166130012545 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1166130012546 active site 1166130012547 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1166130012548 Ligand Binding Site [chemical binding]; other site 1166130012549 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1166130012550 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1166130012551 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1166130012552 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 1166130012553 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1166130012554 active site 1166130012555 motif I; other site 1166130012556 motif II; other site 1166130012557 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1166130012558 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1166130012559 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1166130012560 catalytic residue [active] 1166130012561 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1166130012562 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1166130012563 AsnC family; Region: AsnC_trans_reg; pfam01037 1166130012564 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1166130012565 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1166130012566 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166130012567 Walker A/P-loop; other site 1166130012568 ATP binding site [chemical binding]; other site 1166130012569 Q-loop/lid; other site 1166130012570 ABC transporter signature motif; other site 1166130012571 Walker B; other site 1166130012572 D-loop; other site 1166130012573 H-loop/switch region; other site 1166130012574 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 1166130012575 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1166130012576 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166130012577 Walker A/P-loop; other site 1166130012578 ATP binding site [chemical binding]; other site 1166130012579 Q-loop/lid; other site 1166130012580 ABC transporter signature motif; other site 1166130012581 Walker B; other site 1166130012582 D-loop; other site 1166130012583 H-loop/switch region; other site 1166130012584 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 1166130012585 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1166130012586 ammonium transporter; Provisional; Region: PRK10666 1166130012587 acyl-CoA thioesterase II; Provisional; Region: PRK10526 1166130012588 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1166130012589 active site 1166130012590 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1166130012591 catalytic triad [active] 1166130012592 dimer interface [polypeptide binding]; other site 1166130012593 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 1166130012594 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1166130012595 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1166130012596 DNA binding site [nucleotide binding] 1166130012597 active site 1166130012598 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1166130012599 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1166130012600 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166130012601 DNA-binding site [nucleotide binding]; DNA binding site 1166130012602 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1166130012603 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130012604 homodimer interface [polypeptide binding]; other site 1166130012605 catalytic residue [active] 1166130012606 Predicted membrane protein [Function unknown]; Region: COG2364 1166130012607 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1166130012608 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1166130012609 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1166130012610 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1166130012611 lac repressor; Reviewed; Region: lacI; PRK09526 1166130012612 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1166130012613 DNA binding site [nucleotide binding] 1166130012614 domain linker motif; other site 1166130012615 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1166130012616 dimerization interface (open form) [polypeptide binding]; other site 1166130012617 ligand binding site [chemical binding]; other site 1166130012618 dimerization interface (closed form) [polypeptide binding]; other site 1166130012619 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 1166130012620 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1166130012621 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1166130012622 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1166130012623 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 1166130012624 Protein of unknown function (DUF1428); Region: DUF1428; cl02319 1166130012625 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1166130012626 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1166130012627 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1166130012628 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1166130012629 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1166130012630 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166130012631 DNA-binding site [nucleotide binding]; DNA binding site 1166130012632 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1166130012633 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1166130012634 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 1166130012635 metal binding site [ion binding]; metal-binding site 1166130012636 substrate binding pocket [chemical binding]; other site 1166130012637 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1166130012638 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1166130012639 active site turn [active] 1166130012640 phosphorylation site [posttranslational modification] 1166130012641 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1166130012642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130012643 dimer interface [polypeptide binding]; other site 1166130012644 conserved gate region; other site 1166130012645 ABC-ATPase subunit interface; other site 1166130012646 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1166130012647 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1166130012648 Walker A/P-loop; other site 1166130012649 ATP binding site [chemical binding]; other site 1166130012650 Q-loop/lid; other site 1166130012651 ABC transporter signature motif; other site 1166130012652 Walker B; other site 1166130012653 D-loop; other site 1166130012654 H-loop/switch region; other site 1166130012655 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1166130012656 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1166130012657 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1166130012658 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1166130012659 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1166130012660 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1166130012661 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1166130012662 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1166130012663 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1166130012664 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1166130012665 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166130012666 DNA-binding site [nucleotide binding]; DNA binding site 1166130012667 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1166130012668 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130012669 homodimer interface [polypeptide binding]; other site 1166130012670 catalytic residue [active] 1166130012671 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 1166130012672 maltose O-acetyltransferase; Provisional; Region: PRK10092 1166130012673 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1166130012674 active site 1166130012675 substrate binding site [chemical binding]; other site 1166130012676 trimer interface [polypeptide binding]; other site 1166130012677 CoA binding site [chemical binding]; other site 1166130012678 gene expression modulator; Provisional; Region: PRK10945 1166130012679 Hha toxicity attenuator; Provisional; Region: PRK10667 1166130012680 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 1166130012681 Protein export membrane protein; Region: SecD_SecF; cl14618 1166130012682 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1166130012683 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1166130012684 HlyD family secretion protein; Region: HlyD_3; pfam13437 1166130012685 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 1166130012686 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1166130012687 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1166130012688 hypothetical protein; Provisional; Region: PRK11281 1166130012689 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1166130012690 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 1166130012691 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1166130012692 hypothetical protein; Provisional; Region: PRK11038 1166130012693 Primosomal replication protein priB and priC; Region: priB_priC; cl11483 1166130012694 hypothetical protein; Provisional; Region: PRK10527 1166130012695 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1166130012696 active site 1166130012697 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166130012698 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 1166130012699 Walker A motif; other site 1166130012700 ATP binding site [chemical binding]; other site 1166130012701 Walker B motif; other site 1166130012702 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1166130012703 arginine finger; other site 1166130012704 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1166130012705 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 1166130012706 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 1166130012707 hypothetical protein; Validated; Region: PRK00153 1166130012708 recombination protein RecR; Reviewed; Region: recR; PRK00076 1166130012709 RecR protein; Region: RecR; pfam02132 1166130012710 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1166130012711 putative active site [active] 1166130012712 putative metal-binding site [ion binding]; other site 1166130012713 tetramer interface [polypeptide binding]; other site 1166130012714 heat shock protein 90; Provisional; Region: PRK05218 1166130012715 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166130012716 ATP binding site [chemical binding]; other site 1166130012717 Mg2+ binding site [ion binding]; other site 1166130012718 G-X-G motif; other site 1166130012719 adenylate kinase; Reviewed; Region: adk; PRK00279 1166130012720 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1166130012721 AMP-binding site [chemical binding]; other site 1166130012722 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1166130012723 ferrochelatase; Reviewed; Region: hemH; PRK00035 1166130012724 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1166130012725 C-terminal domain interface [polypeptide binding]; other site 1166130012726 active site 1166130012727 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1166130012728 active site 1166130012729 N-terminal domain interface [polypeptide binding]; other site 1166130012730 inosine/guanosine kinase; Provisional; Region: PRK15074 1166130012731 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1166130012732 putative cation:proton antiport protein; Provisional; Region: PRK10669 1166130012733 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 1166130012734 TrkA-N domain; Region: TrkA_N; pfam02254 1166130012735 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130012736 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1166130012737 putative substrate translocation pore; other site 1166130012738 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 1166130012739 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 1166130012740 active site 1166130012741 metal binding site [ion binding]; metal-binding site 1166130012742 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1166130012743 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1166130012744 putative deacylase active site [active] 1166130012745 TraB family; Region: TraB; cl12050 1166130012746 copper exporting ATPase; Provisional; Region: copA; PRK10671 1166130012747 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1166130012748 metal-binding site [ion binding] 1166130012749 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1166130012750 metal-binding site [ion binding] 1166130012751 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1166130012752 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1166130012753 motif II; other site 1166130012754 TM2 domain; Region: TM2; pfam05154 1166130012755 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 1166130012756 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1166130012757 DNA binding residues [nucleotide binding] 1166130012758 dimer interface [polypeptide binding]; other site 1166130012759 copper binding site [ion binding]; other site 1166130012760 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 1166130012761 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1166130012762 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1166130012763 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1166130012764 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1166130012765 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1166130012766 oxidoreductase; Provisional; Region: PRK08017 1166130012767 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1166130012768 NADP binding site [chemical binding]; other site 1166130012769 active site 1166130012770 steroid binding site; other site 1166130012771 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1166130012772 active site 1166130012773 catalytic triad [active] 1166130012774 oxyanion hole [active] 1166130012775 switch loop; other site 1166130012776 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 1166130012777 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1166130012778 Walker A/P-loop; other site 1166130012779 ATP binding site [chemical binding]; other site 1166130012780 Q-loop/lid; other site 1166130012781 ABC transporter signature motif; other site 1166130012782 Walker B; other site 1166130012783 D-loop; other site 1166130012784 H-loop/switch region; other site 1166130012785 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1166130012786 FtsX-like permease family; Region: FtsX; pfam02687 1166130012787 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1166130012788 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1166130012789 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1166130012790 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1166130012791 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1166130012792 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1166130012793 Walker A/P-loop; other site 1166130012794 ATP binding site [chemical binding]; other site 1166130012795 Q-loop/lid; other site 1166130012796 ABC transporter signature motif; other site 1166130012797 Walker B; other site 1166130012798 D-loop; other site 1166130012799 H-loop/switch region; other site 1166130012800 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1166130012801 NIL domain; Region: NIL; pfam09383 1166130012802 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130012803 dimer interface [polypeptide binding]; other site 1166130012804 conserved gate region; other site 1166130012805 ABC-ATPase subunit interface; other site 1166130012806 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1166130012807 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 1166130012808 active site residue [active] 1166130012809 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1166130012810 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1166130012811 ATP-grasp domain; Region: ATP-grasp; pfam02222 1166130012812 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1166130012813 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1166130012814 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1166130012815 putative active site [active] 1166130012816 putative metal binding site [ion binding]; other site 1166130012817 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1166130012818 substrate binding site [chemical binding]; other site 1166130012819 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1166130012820 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1166130012821 active site 1166130012822 HIGH motif; other site 1166130012823 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1166130012824 KMSKS motif; other site 1166130012825 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1166130012826 tRNA binding surface [nucleotide binding]; other site 1166130012827 anticodon binding site; other site 1166130012828 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1166130012829 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 1166130012830 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1166130012831 DNA binding site [nucleotide binding] 1166130012832 domain linker motif; other site 1166130012833 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1166130012834 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1166130012835 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1166130012836 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1166130012837 active site turn [active] 1166130012838 phosphorylation site [posttranslational modification] 1166130012839 ribosome-associated protein; Provisional; Region: PRK11507 1166130012840 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 1166130012841 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1166130012842 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1166130012843 homodimer interface [polypeptide binding]; other site 1166130012844 NADP binding site [chemical binding]; other site 1166130012845 substrate binding site [chemical binding]; other site 1166130012846 Fimbrial protein; Region: Fimbrial; cl01416 1166130012847 Fimbrial protein; Region: Fimbrial; cl01416 1166130012848 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 1166130012849 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1166130012850 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1166130012851 outer membrane usher protein FimD; Provisional; Region: PRK15198 1166130012852 PapC N-terminal domain; Region: PapC_N; pfam13954 1166130012853 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1166130012854 PapC C-terminal domain; Region: PapC_C; pfam13953 1166130012855 Fimbrial protein; Region: Fimbrial; cl01416 1166130012856 Fimbrial protein; Region: Fimbrial; cl01416 1166130012857 transcriptional regulator FimZ; Provisional; Region: PRK09935 1166130012858 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130012859 active site 1166130012860 phosphorylation site [posttranslational modification] 1166130012861 intermolecular recognition site; other site 1166130012862 dimerization interface [polypeptide binding]; other site 1166130012863 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1166130012864 DNA binding residues [nucleotide binding] 1166130012865 dimerization interface [polypeptide binding]; other site 1166130012866 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1166130012867 Sigma-S stabilisation anti-adaptor protein; Region: Anti-adapt_IraP; cl11681 1166130012868 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1166130012869 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1166130012870 putative dimer interface [polypeptide binding]; other site 1166130012871 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1166130012872 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1166130012873 active site 1166130012874 substrate binding site [chemical binding]; other site 1166130012875 coenzyme B12 binding site [chemical binding]; other site 1166130012876 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1166130012877 B12 binding site [chemical binding]; other site 1166130012878 cobalt ligand [ion binding]; other site 1166130012879 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1166130012880 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1166130012881 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1166130012882 methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423 1166130012883 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1166130012884 substrate binding site [chemical binding]; other site 1166130012885 oxyanion hole (OAH) forming residues; other site 1166130012886 trimer interface [polypeptide binding]; other site 1166130012887 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1166130012888 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1166130012889 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1166130012890 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166130012891 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130012892 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1166130012893 dimerization interface [polypeptide binding]; other site 1166130012894 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166130012895 Coenzyme A binding pocket [chemical binding]; other site 1166130012896 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1166130012897 CAT RNA binding domain; Region: CAT_RBD; smart01061 1166130012898 PRD domain; Region: PRD; pfam00874 1166130012899 PRD domain; Region: PRD; pfam00874 1166130012900 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1166130012901 beta-galactosidase; Region: BGL; TIGR03356 1166130012902 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1166130012903 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1166130012904 active site turn [active] 1166130012905 phosphorylation site [posttranslational modification] 1166130012906 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1166130012907 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1166130012908 HPr interaction site; other site 1166130012909 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1166130012910 active site 1166130012911 phosphorylation site [posttranslational modification] 1166130012912 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 1166130012913 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1166130012914 trimer interface; other site 1166130012915 sugar binding site [chemical binding]; other site 1166130012916 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 1166130012917 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1166130012918 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166130012919 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130012920 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1166130012921 putative effector binding pocket; other site 1166130012922 putative dimerization interface [polypeptide binding]; other site 1166130012923 short chain dehydrogenase; Provisional; Region: PRK06500 1166130012924 classical (c) SDRs; Region: SDR_c; cd05233 1166130012925 NAD(P) binding site [chemical binding]; other site 1166130012926 active site 1166130012927 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1166130012928 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1166130012929 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1166130012930 putative di-iron ligands [ion binding]; other site 1166130012931 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1166130012932 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1166130012933 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1166130012934 active site 1166130012935 FMN binding site [chemical binding]; other site 1166130012936 substrate binding site [chemical binding]; other site 1166130012937 homotetramer interface [polypeptide binding]; other site 1166130012938 catalytic residue [active] 1166130012939 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1166130012940 HAMP domain; Region: HAMP; pfam00672 1166130012941 dimerization interface [polypeptide binding]; other site 1166130012942 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166130012943 dimer interface [polypeptide binding]; other site 1166130012944 putative CheW interface [polypeptide binding]; other site 1166130012945 Periplasmic pectate lyase; Region: Pectate_lyase_2; pfam06917 1166130012946 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 1166130012947 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1166130012948 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1166130012949 DNA binding residues [nucleotide binding] 1166130012950 dimerization interface [polypeptide binding]; other site 1166130012951 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1166130012952 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1166130012953 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1166130012954 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1166130012955 DNA binding residues [nucleotide binding] 1166130012956 dimerization interface [polypeptide binding]; other site 1166130012957 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1166130012958 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130012959 dimer interface [polypeptide binding]; other site 1166130012960 conserved gate region; other site 1166130012961 putative PBP binding loops; other site 1166130012962 ABC-ATPase subunit interface; other site 1166130012963 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1166130012964 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130012965 dimer interface [polypeptide binding]; other site 1166130012966 conserved gate region; other site 1166130012967 putative PBP binding loops; other site 1166130012968 ABC-ATPase subunit interface; other site 1166130012969 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1166130012970 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1166130012971 Walker A/P-loop; other site 1166130012972 ATP binding site [chemical binding]; other site 1166130012973 Q-loop/lid; other site 1166130012974 ABC transporter signature motif; other site 1166130012975 Walker B; other site 1166130012976 D-loop; other site 1166130012977 H-loop/switch region; other site 1166130012978 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1166130012979 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1166130012980 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1166130012981 Walker A/P-loop; other site 1166130012982 ATP binding site [chemical binding]; other site 1166130012983 Q-loop/lid; other site 1166130012984 ABC transporter signature motif; other site 1166130012985 Walker B; other site 1166130012986 D-loop; other site 1166130012987 H-loop/switch region; other site 1166130012988 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1166130012989 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1166130012990 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1166130012991 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1166130012992 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1166130012993 Walker A/P-loop; other site 1166130012994 ATP binding site [chemical binding]; other site 1166130012995 Q-loop/lid; other site 1166130012996 ABC transporter signature motif; other site 1166130012997 Walker B; other site 1166130012998 D-loop; other site 1166130012999 H-loop/switch region; other site 1166130013000 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1166130013001 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1166130013002 putative PBP binding regions; other site 1166130013003 ABC-ATPase subunit interface; other site 1166130013004 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 1166130013005 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1166130013006 putative ligand binding residues [chemical binding]; other site 1166130013007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130013008 putative substrate translocation pore; other site 1166130013009 KTSC domain; Region: KTSC; pfam13619 1166130013010 transcriptional regulator; Provisional; Region: PRK10632 1166130013011 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130013012 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1166130013013 putative effector binding pocket; other site 1166130013014 dimerization interface [polypeptide binding]; other site 1166130013015 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1166130013016 DNA binding residues [nucleotide binding] 1166130013017 dimerization interface [polypeptide binding]; other site 1166130013018 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1166130013019 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 1166130013020 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1166130013021 catalytic residues [active] 1166130013022 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1166130013023 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 1166130013024 conserved cys residue [active] 1166130013025 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130013026 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1166130013027 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1166130013028 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1166130013029 YCII-related domain; Region: YCII; cl00999 1166130013030 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1166130013031 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130013032 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1166130013033 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1166130013034 trimer interface [polypeptide binding]; other site 1166130013035 eyelet of channel; other site 1166130013036 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166130013037 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130013038 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1166130013039 putative effector binding pocket; other site 1166130013040 putative dimerization interface [polypeptide binding]; other site 1166130013041 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1166130013042 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 1166130013043 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1166130013044 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1166130013045 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1166130013046 NAD(P) binding site [chemical binding]; other site 1166130013047 active site 1166130013048 hypothetical protein; Provisional; Region: PRK06062 1166130013049 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1166130013050 inhibitor-cofactor binding pocket; inhibition site 1166130013051 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130013052 catalytic residue [active] 1166130013053 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1166130013054 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1166130013055 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1166130013056 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1166130013057 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166130013058 dimer interface [polypeptide binding]; other site 1166130013059 putative CheW interface [polypeptide binding]; other site 1166130013060 outer membrane receptor FepA; Provisional; Region: PRK13524 1166130013061 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1166130013062 N-terminal plug; other site 1166130013063 ligand-binding site [chemical binding]; other site 1166130013064 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 1166130013065 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 1166130013066 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1166130013067 MbtH-like protein; Region: MbtH; cl01279 1166130013068 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1166130013069 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1166130013070 acyl-activating enzyme (AAE) consensus motif; other site 1166130013071 AMP binding site [chemical binding]; other site 1166130013072 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1166130013073 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1166130013074 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1166130013075 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1166130013076 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 1166130013077 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1166130013078 Walker A/P-loop; other site 1166130013079 ATP binding site [chemical binding]; other site 1166130013080 Q-loop/lid; other site 1166130013081 ABC transporter signature motif; other site 1166130013082 Walker B; other site 1166130013083 D-loop; other site 1166130013084 H-loop/switch region; other site 1166130013085 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1166130013086 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1166130013087 ABC-ATPase subunit interface; other site 1166130013088 dimer interface [polypeptide binding]; other site 1166130013089 putative PBP binding regions; other site 1166130013090 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1166130013091 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1166130013092 ABC-ATPase subunit interface; other site 1166130013093 dimer interface [polypeptide binding]; other site 1166130013094 putative PBP binding regions; other site 1166130013095 enterobactin exporter EntS; Provisional; Region: PRK10489 1166130013096 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130013097 putative substrate translocation pore; other site 1166130013098 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 1166130013099 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1166130013100 siderophore binding site; other site 1166130013101 isochorismate synthase EntC; Provisional; Region: PRK15016 1166130013102 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1166130013103 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 1166130013104 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1166130013105 acyl-activating enzyme (AAE) consensus motif; other site 1166130013106 active site 1166130013107 AMP binding site [chemical binding]; other site 1166130013108 substrate binding site [chemical binding]; other site 1166130013109 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1166130013110 hydrophobic substrate binding pocket; other site 1166130013111 Isochorismatase family; Region: Isochorismatase; pfam00857 1166130013112 active site 1166130013113 conserved cis-peptide bond; other site 1166130013114 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1166130013115 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1166130013116 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1166130013117 NAD(P) binding site [chemical binding]; other site 1166130013118 active site 1166130013119 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1166130013120 CoenzymeA binding site [chemical binding]; other site 1166130013121 subunit interaction site [polypeptide binding]; other site 1166130013122 PHB binding site; other site 1166130013123 carbon starvation protein A; Provisional; Region: PRK15015 1166130013124 Carbon starvation protein CstA; Region: CstA; pfam02554 1166130013125 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1166130013126 Uncharacterized small protein [Function unknown]; Region: COG2879 1166130013127 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1166130013128 classical (c) SDRs; Region: SDR_c; cd05233 1166130013129 NAD(P) binding site [chemical binding]; other site 1166130013130 active site 1166130013131 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1166130013132 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1166130013133 choline transport protein BetT; Provisional; Region: PRK09928 1166130013134 transcriptional regulator BetI; Validated; Region: PRK00767 1166130013135 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1166130013136 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1166130013137 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 1166130013138 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1166130013139 NAD(P) binding site [chemical binding]; other site 1166130013140 catalytic residues [active] 1166130013141 choline dehydrogenase; Validated; Region: PRK02106 1166130013142 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1166130013143 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1166130013144 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 1166130013145 putative active site [active] 1166130013146 metal binding site [ion binding]; metal-binding site 1166130013147 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1166130013148 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1166130013149 Walker A/P-loop; other site 1166130013150 ATP binding site [chemical binding]; other site 1166130013151 Q-loop/lid; other site 1166130013152 ABC transporter signature motif; other site 1166130013153 Walker B; other site 1166130013154 D-loop; other site 1166130013155 H-loop/switch region; other site 1166130013156 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1166130013157 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1166130013158 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1166130013159 TM-ABC transporter signature motif; other site 1166130013160 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 1166130013161 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1166130013162 putative ligand binding site [chemical binding]; other site 1166130013163 Uncharacterized conserved protein [Function unknown]; Region: COG5276 1166130013164 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 1166130013165 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 1166130013166 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1166130013167 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 1166130013168 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1166130013169 intersubunit interface [polypeptide binding]; other site 1166130013170 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1166130013171 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1166130013172 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1166130013173 ABC-ATPase subunit interface; other site 1166130013174 dimer interface [polypeptide binding]; other site 1166130013175 putative PBP binding regions; other site 1166130013176 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1166130013177 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1166130013178 Walker A/P-loop; other site 1166130013179 ATP binding site [chemical binding]; other site 1166130013180 Q-loop/lid; other site 1166130013181 ABC transporter signature motif; other site 1166130013182 Walker B; other site 1166130013183 D-loop; other site 1166130013184 H-loop/switch region; other site 1166130013185 Tetratrico peptide repeat; Region: TPR_5; pfam12688 1166130013186 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1166130013187 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 1166130013188 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1166130013189 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1166130013190 N-terminal plug; other site 1166130013191 ligand-binding site [chemical binding]; other site 1166130013192 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1166130013193 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1166130013194 siderophore binding site; other site 1166130013195 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1166130013196 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1166130013197 ABC-ATPase subunit interface; other site 1166130013198 dimer interface [polypeptide binding]; other site 1166130013199 putative PBP binding regions; other site 1166130013200 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1166130013201 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1166130013202 ABC-ATPase subunit interface; other site 1166130013203 dimer interface [polypeptide binding]; other site 1166130013204 putative PBP binding regions; other site 1166130013205 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1166130013206 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1166130013207 Walker A/P-loop; other site 1166130013208 ATP binding site [chemical binding]; other site 1166130013209 Q-loop/lid; other site 1166130013210 ABC transporter signature motif; other site 1166130013211 Walker B; other site 1166130013212 D-loop; other site 1166130013213 H-loop/switch region; other site 1166130013214 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 1166130013215 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1166130013216 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1166130013217 Cupin domain; Region: Cupin_2; cl17218 1166130013218 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1166130013219 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130013220 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130013221 2-isopropylmalate synthase; Validated; Region: PRK03739 1166130013222 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1166130013223 active site 1166130013224 catalytic residues [active] 1166130013225 metal binding site [ion binding]; metal-binding site 1166130013226 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1166130013227 haemagglutination activity domain; Region: Haemagg_act; smart00912 1166130013228 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1166130013229 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1166130013230 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 1166130013231 SdpI/YhfL protein family; Region: SdpI; pfam13630 1166130013232 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1166130013233 Tar ligand binding domain homologue; Region: TarH; pfam02203 1166130013234 HAMP domain; Region: HAMP; pfam00672 1166130013235 dimerization interface [polypeptide binding]; other site 1166130013236 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1166130013237 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166130013238 dimer interface [polypeptide binding]; other site 1166130013239 putative CheW interface [polypeptide binding]; other site 1166130013240 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 1166130013241 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1166130013242 non-specific DNA binding site [nucleotide binding]; other site 1166130013243 salt bridge; other site 1166130013244 sequence-specific DNA binding site [nucleotide binding]; other site 1166130013245 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1166130013246 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1166130013247 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 1166130013248 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1166130013249 Cupin domain; Region: Cupin_2; cl17218 1166130013250 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691 1166130013251 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 1166130013252 intersubunit interface [polypeptide binding]; other site 1166130013253 active site 1166130013254 Zn2+ binding site [ion binding]; other site 1166130013255 methionine aminotransferase; Validated; Region: PRK09082 1166130013256 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1166130013257 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130013258 homodimer interface [polypeptide binding]; other site 1166130013259 catalytic residue [active] 1166130013260 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 1166130013261 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1166130013262 dimerization domain [polypeptide binding]; other site 1166130013263 dimer interface [polypeptide binding]; other site 1166130013264 catalytic residues [active] 1166130013265 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 1166130013266 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1166130013267 dimer interface [polypeptide binding]; other site 1166130013268 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1166130013269 catalytic triad [active] 1166130013270 peroxidatic and resolving cysteines [active] 1166130013271 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1166130013272 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1166130013273 catalytic residue [active] 1166130013274 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1166130013275 catalytic residues [active] 1166130013276 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1166130013277 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1166130013278 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1166130013279 Ligand Binding Site [chemical binding]; other site 1166130013280 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 1166130013281 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1166130013282 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 1166130013283 B1 nucleotide binding pocket [chemical binding]; other site 1166130013284 B2 nucleotide binding pocket [chemical binding]; other site 1166130013285 CAS motifs; other site 1166130013286 active site 1166130013287 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 1166130013288 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1166130013289 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 1166130013290 Outer membrane efflux protein; Region: OEP; pfam02321 1166130013291 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 1166130013292 HlyD family secretion protein; Region: HlyD_3; pfam13437 1166130013293 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 1166130013294 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1166130013295 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 1166130013296 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1166130013297 DNA-binding site [nucleotide binding]; DNA binding site 1166130013298 RNA-binding motif; other site 1166130013299 chromosome condensation membrane protein; Provisional; Region: PRK14196 1166130013300 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1166130013301 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1166130013302 putative active site [active] 1166130013303 catalytic triad [active] 1166130013304 putative dimer interface [polypeptide binding]; other site 1166130013305 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 1166130013306 lipoyl synthase; Provisional; Region: PRK05481 1166130013307 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1166130013308 FeS/SAM binding site; other site 1166130013309 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 1166130013310 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130013311 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1166130013312 substrate binding pocket [chemical binding]; other site 1166130013313 dimerization interface [polypeptide binding]; other site 1166130013314 lipoate-protein ligase B; Provisional; Region: PRK14342 1166130013315 hypothetical protein; Provisional; Region: PRK04998 1166130013316 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 1166130013317 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1166130013318 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1166130013319 rare lipoprotein A; Provisional; Region: PRK10672 1166130013320 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1166130013321 Sporulation related domain; Region: SPOR; pfam05036 1166130013322 cell wall shape-determining protein; Provisional; Region: PRK10794 1166130013323 penicillin-binding protein 2; Provisional; Region: PRK10795 1166130013324 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1166130013325 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1166130013326 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 1166130013327 ribosome-associated protein; Provisional; Region: PRK11538 1166130013328 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1166130013329 catalytic core [active] 1166130013330 threonine-phosphate decarboxylase; Provisional; Region: PRK08056 1166130013331 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1166130013332 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130013333 homodimer interface [polypeptide binding]; other site 1166130013334 catalytic residue [active] 1166130013335 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1166130013336 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1166130013337 active site 1166130013338 (T/H)XGH motif; other site 1166130013339 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1166130013340 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1166130013341 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 1166130013342 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1166130013343 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1166130013344 HIGH motif; other site 1166130013345 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1166130013346 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1166130013347 active site 1166130013348 KMSKS motif; other site 1166130013349 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1166130013350 tRNA binding surface [nucleotide binding]; other site 1166130013351 hypothetical protein; Provisional; Region: PRK11032 1166130013352 SPX domain; Region: SPX; pfam03105 1166130013353 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1166130013354 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1166130013355 Walker A/P-loop; other site 1166130013356 ATP binding site [chemical binding]; other site 1166130013357 Q-loop/lid; other site 1166130013358 ABC transporter signature motif; other site 1166130013359 Walker B; other site 1166130013360 D-loop; other site 1166130013361 H-loop/switch region; other site 1166130013362 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1166130013363 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130013364 dimer interface [polypeptide binding]; other site 1166130013365 conserved gate region; other site 1166130013366 putative PBP binding loops; other site 1166130013367 ABC-ATPase subunit interface; other site 1166130013368 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1166130013369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130013370 dimer interface [polypeptide binding]; other site 1166130013371 conserved gate region; other site 1166130013372 putative PBP binding loops; other site 1166130013373 ABC-ATPase subunit interface; other site 1166130013374 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 1166130013375 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166130013376 substrate binding pocket [chemical binding]; other site 1166130013377 membrane-bound complex binding site; other site 1166130013378 hinge residues; other site 1166130013379 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1166130013380 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1166130013381 putative active site [active] 1166130013382 catalytic triad [active] 1166130013383 putative dimer interface [polypeptide binding]; other site 1166130013384 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 1166130013385 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1166130013386 Transporter associated domain; Region: CorC_HlyC; smart01091 1166130013387 metal-binding heat shock protein; Provisional; Region: PRK00016 1166130013388 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1166130013389 PhoH-like protein; Region: PhoH; pfam02562 1166130013390 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1166130013391 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1166130013392 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1166130013393 FeS/SAM binding site; other site 1166130013394 TRAM domain; Region: TRAM; pfam01938 1166130013395 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 1166130013396 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1166130013397 asparagine synthetase B; Provisional; Region: asnB; PRK09431 1166130013398 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1166130013399 active site 1166130013400 dimer interface [polypeptide binding]; other site 1166130013401 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1166130013402 Ligand Binding Site [chemical binding]; other site 1166130013403 Molecular Tunnel; other site 1166130013404 UMP phosphatase; Provisional; Region: PRK10444 1166130013405 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1166130013406 active site 1166130013407 motif I; other site 1166130013408 motif II; other site 1166130013409 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1166130013410 MarR family; Region: MarR; pfam01047 1166130013411 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1166130013412 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1166130013413 nucleotide binding site [chemical binding]; other site 1166130013414 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 1166130013415 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1166130013416 active site 1166130013417 dimer interface [polypeptide binding]; other site 1166130013418 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1166130013419 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1166130013420 active site 1166130013421 trimer interface [polypeptide binding]; other site 1166130013422 allosteric site; other site 1166130013423 active site lid [active] 1166130013424 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1166130013425 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 1166130013426 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1166130013427 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1166130013428 active site turn [active] 1166130013429 phosphorylation site [posttranslational modification] 1166130013430 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1166130013431 HPr interaction site; other site 1166130013432 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1166130013433 active site 1166130013434 phosphorylation site [posttranslational modification] 1166130013435 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1166130013436 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1166130013437 active site 1166130013438 HIGH motif; other site 1166130013439 nucleotide binding site [chemical binding]; other site 1166130013440 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1166130013441 KMSKS motif; other site 1166130013442 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1166130013443 outer membrane porin, OprD family; Region: OprD; pfam03573 1166130013444 Putative carbohydrate binding domain; Region: CHB_HEX; smart01081 1166130013445 N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525 1166130013446 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 1166130013447 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a...; Region: GH20_Sm-chitobiase-like; cd06569 1166130013448 active site 1166130013449 C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847 1166130013450 ferric uptake regulator; Provisional; Region: fur; PRK09462 1166130013451 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1166130013452 metal binding site 2 [ion binding]; metal-binding site 1166130013453 putative DNA binding helix; other site 1166130013454 metal binding site 1 [ion binding]; metal-binding site 1166130013455 dimer interface [polypeptide binding]; other site 1166130013456 structural Zn2+ binding site [ion binding]; other site 1166130013457 flavodoxin FldA; Validated; Region: PRK09267 1166130013458 LexA regulated protein; Provisional; Region: PRK11675 1166130013459 acyl-CoA esterase; Provisional; Region: PRK10673 1166130013460 PGAP1-like protein; Region: PGAP1; pfam07819 1166130013461 replication initiation regulator SeqA; Provisional; Region: PRK11187 1166130013462 phosphoglucomutase; Validated; Region: PRK07564 1166130013463 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1166130013464 active site 1166130013465 substrate binding site [chemical binding]; other site 1166130013466 metal binding site [ion binding]; metal-binding site 1166130013467 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1166130013468 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1166130013469 Predicted membrane protein [Function unknown]; Region: COG2510 1166130013470 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1166130013471 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130013472 active site 1166130013473 phosphorylation site [posttranslational modification] 1166130013474 intermolecular recognition site; other site 1166130013475 dimerization interface [polypeptide binding]; other site 1166130013476 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1166130013477 DNA binding site [nucleotide binding] 1166130013478 sensor protein KdpD; Provisional; Region: PRK10490 1166130013479 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1166130013480 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1166130013481 Ligand Binding Site [chemical binding]; other site 1166130013482 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1166130013483 GAF domain; Region: GAF_3; pfam13492 1166130013484 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1166130013485 dimer interface [polypeptide binding]; other site 1166130013486 phosphorylation site [posttranslational modification] 1166130013487 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166130013488 ATP binding site [chemical binding]; other site 1166130013489 Mg2+ binding site [ion binding]; other site 1166130013490 G-X-G motif; other site 1166130013491 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 1166130013492 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1166130013493 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1166130013494 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1166130013495 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 1166130013496 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 1166130013497 DNA photolyase; Region: DNA_photolyase; pfam00875 1166130013498 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1166130013499 metal-binding protein; Provisional; Region: PRK10799 1166130013500 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1166130013501 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1166130013502 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1166130013503 LamB/YcsF family protein; Provisional; Region: PRK05406 1166130013504 endonuclease VIII; Provisional; Region: PRK10445 1166130013505 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 1166130013506 DNA binding site [nucleotide binding] 1166130013507 catalytic residue [active] 1166130013508 putative catalytic residues [active] 1166130013509 H2TH interface [polypeptide binding]; other site 1166130013510 intercalation triad [nucleotide binding]; other site 1166130013511 substrate specificity determining residue; other site 1166130013512 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1166130013513 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1166130013514 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1166130013515 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1166130013516 dimer interface [polypeptide binding]; other site 1166130013517 active site 1166130013518 citrylCoA binding site [chemical binding]; other site 1166130013519 NADH binding [chemical binding]; other site 1166130013520 cationic pore residues; other site 1166130013521 oxalacetate/citrate binding site [chemical binding]; other site 1166130013522 coenzyme A binding site [chemical binding]; other site 1166130013523 catalytic triad [active] 1166130013524 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1166130013525 Iron-sulfur protein interface; other site 1166130013526 proximal quinone binding site [chemical binding]; other site 1166130013527 SdhD (CybS) interface [polypeptide binding]; other site 1166130013528 proximal heme binding site [chemical binding]; other site 1166130013529 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 1166130013530 SdhC subunit interface [polypeptide binding]; other site 1166130013531 proximal heme binding site [chemical binding]; other site 1166130013532 cardiolipin binding site; other site 1166130013533 Iron-sulfur protein interface; other site 1166130013534 proximal quinone binding site [chemical binding]; other site 1166130013535 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 1166130013536 L-aspartate oxidase; Provisional; Region: PRK06175 1166130013537 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1166130013538 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1166130013539 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1166130013540 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1166130013541 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1166130013542 TPP-binding site [chemical binding]; other site 1166130013543 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1166130013544 dimer interface [polypeptide binding]; other site 1166130013545 PYR/PP interface [polypeptide binding]; other site 1166130013546 TPP binding site [chemical binding]; other site 1166130013547 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1166130013548 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1166130013549 E3 interaction surface; other site 1166130013550 lipoyl attachment site [posttranslational modification]; other site 1166130013551 e3 binding domain; Region: E3_binding; pfam02817 1166130013552 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1166130013553 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1166130013554 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1166130013555 CoA-ligase; Region: Ligase_CoA; pfam00549 1166130013556 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1166130013557 CoA binding domain; Region: CoA_binding; smart00881 1166130013558 CoA-ligase; Region: Ligase_CoA; pfam00549 1166130013559 Predicted transcriptional regulators [Transcription]; Region: COG1733 1166130013560 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1166130013561 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1166130013562 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1166130013563 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1166130013564 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1166130013565 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 1166130013566 hypothetical protein; Provisional; Region: PRK10588 1166130013567 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1166130013568 active site 1166130013569 colicin uptake protein TolQ; Provisional; Region: PRK10801 1166130013570 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1166130013571 colicin uptake protein TolR; Provisional; Region: PRK11024 1166130013572 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 1166130013573 TolA C-terminal; Region: TolA; pfam06519 1166130013574 translocation protein TolB; Provisional; Region: tolB; PRK03629 1166130013575 TolB amino-terminal domain; Region: TolB_N; pfam04052 1166130013576 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1166130013577 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1166130013578 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1166130013579 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 1166130013580 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1166130013581 ligand binding site [chemical binding]; other site 1166130013582 tol-pal system protein YbgF; Provisional; Region: PRK10803 1166130013583 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1166130013584 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1166130013585 quinolinate synthetase; Provisional; Region: PRK09375 1166130013586 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 1166130013587 zinc transporter ZitB; Provisional; Region: PRK03557 1166130013588 YbgS-like protein; Region: YbgS; pfam13985 1166130013589 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1166130013590 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1166130013591 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1166130013592 catalytic core [active] 1166130013593 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1166130013594 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1166130013595 active site 1166130013596 catalytic residues [active] 1166130013597 galactokinase; Provisional; Region: PRK05101 1166130013598 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1166130013599 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1166130013600 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 1166130013601 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1166130013602 dimer interface [polypeptide binding]; other site 1166130013603 active site 1166130013604 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 1166130013605 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1166130013606 NAD binding site [chemical binding]; other site 1166130013607 homodimer interface [polypeptide binding]; other site 1166130013608 active site 1166130013609 substrate binding site [chemical binding]; other site 1166130013610 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 1166130013611 active site 1166130013612 putative substrate binding region [chemical binding]; other site 1166130013613 Protein of unknown function (DUF2167); Region: DUF2167; cl01938 1166130013614 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 1166130013615 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166130013616 Walker A/P-loop; other site 1166130013617 ATP binding site [chemical binding]; other site 1166130013618 Q-loop/lid; other site 1166130013619 ABC transporter signature motif; other site 1166130013620 Walker B; other site 1166130013621 D-loop; other site 1166130013622 H-loop/switch region; other site 1166130013623 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166130013624 Walker A/P-loop; other site 1166130013625 ATP binding site [chemical binding]; other site 1166130013626 Q-loop/lid; other site 1166130013627 ABC transporter signature motif; other site 1166130013628 Walker B; other site 1166130013629 D-loop; other site 1166130013630 H-loop/switch region; other site 1166130013631 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 1166130013632 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 1166130013633 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1166130013634 TOBE domain; Region: TOBE; pfam03459 1166130013635 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 1166130013636 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 1166130013637 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166130013638 substrate binding pocket [chemical binding]; other site 1166130013639 membrane-bound complex binding site; other site 1166130013640 hinge residues; other site 1166130013641 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1166130013642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130013643 dimer interface [polypeptide binding]; other site 1166130013644 conserved gate region; other site 1166130013645 putative PBP binding loops; other site 1166130013646 ABC-ATPase subunit interface; other site 1166130013647 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 1166130013648 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166130013649 Walker A/P-loop; other site 1166130013650 ATP binding site [chemical binding]; other site 1166130013651 Q-loop/lid; other site 1166130013652 ABC transporter signature motif; other site 1166130013653 Walker B; other site 1166130013654 D-loop; other site 1166130013655 H-loop/switch region; other site 1166130013656 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1166130013657 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 1166130013658 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1166130013659 motif II; other site 1166130013660 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1166130013661 6-phosphogluconolactonase; Provisional; Region: PRK11028 1166130013662 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1166130013663 acyl-CoA thioesterase; Provisional; Region: PRK10531 1166130013664 putative pectinesterase; Region: PLN02432; cl01911 1166130013665 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1166130013666 substrate binding site [chemical binding]; other site 1166130013667 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 1166130013668 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1166130013669 inhibitor-cofactor binding pocket; inhibition site 1166130013670 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130013671 catalytic residue [active] 1166130013672 biotin synthase; Provisional; Region: PRK15108 1166130013673 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1166130013674 FeS/SAM binding site; other site 1166130013675 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1166130013676 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1166130013677 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1166130013678 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1166130013679 catalytic residue [active] 1166130013680 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1166130013681 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166130013682 S-adenosylmethionine binding site [chemical binding]; other site 1166130013683 AAA domain; Region: AAA_26; pfam13500 1166130013684 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1166130013685 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 1166130013686 ADP binding site [chemical binding]; other site 1166130013687 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166130013688 ATP binding site [chemical binding]; other site 1166130013689 Walker A/P-loop; other site 1166130013690 ABC transporter; Region: ABC_tran; pfam00005 1166130013691 Q-loop/lid; other site 1166130013692 ABC transporter signature motif; other site 1166130013693 Walker B; other site 1166130013694 D-loop; other site 1166130013695 H-loop/switch region; other site 1166130013696 excinuclease ABC subunit B; Provisional; Region: PRK05298 1166130013697 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1166130013698 ATP binding site [chemical binding]; other site 1166130013699 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1166130013700 nucleotide binding region [chemical binding]; other site 1166130013701 ATP-binding site [chemical binding]; other site 1166130013702 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1166130013703 UvrB/uvrC motif; Region: UVR; pfam02151 1166130013704 sensor protein BasS/PmrB; Provisional; Region: PRK10755 1166130013705 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1166130013706 dimer interface [polypeptide binding]; other site 1166130013707 phosphorylation site [posttranslational modification] 1166130013708 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166130013709 ATP binding site [chemical binding]; other site 1166130013710 G-X-G motif; other site 1166130013711 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1166130013712 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130013713 active site 1166130013714 phosphorylation site [posttranslational modification] 1166130013715 intermolecular recognition site; other site 1166130013716 dimerization interface [polypeptide binding]; other site 1166130013717 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1166130013718 DNA binding site [nucleotide binding] 1166130013719 putative metal dependent hydrolase; Provisional; Region: PRK11598 1166130013720 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1166130013721 Sulfatase; Region: Sulfatase; pfam00884 1166130013722 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1166130013723 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1166130013724 phosphate binding site [ion binding]; other site 1166130013725 putative substrate binding pocket [chemical binding]; other site 1166130013726 dimer interface [polypeptide binding]; other site 1166130013727 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1166130013728 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1166130013729 FeS/SAM binding site; other site 1166130013730 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1166130013731 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1166130013732 MPT binding site; other site 1166130013733 trimer interface [polypeptide binding]; other site 1166130013734 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1166130013735 trimer interface [polypeptide binding]; other site 1166130013736 dimer interface [polypeptide binding]; other site 1166130013737 putative active site [active] 1166130013738 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1166130013739 MoaE interaction surface [polypeptide binding]; other site 1166130013740 MoeB interaction surface [polypeptide binding]; other site 1166130013741 thiocarboxylated glycine; other site 1166130013742 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1166130013743 MoaE homodimer interface [polypeptide binding]; other site 1166130013744 MoaD interaction [polypeptide binding]; other site 1166130013745 active site residues [active] 1166130013746 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1166130013747 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1166130013748 Predicted integral membrane protein [Function unknown]; Region: COG0392 1166130013749 cardiolipin synthase 2; Provisional; Region: PRK11263 1166130013750 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1166130013751 putative active site [active] 1166130013752 catalytic site [active] 1166130013753 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1166130013754 putative active site [active] 1166130013755 catalytic site [active] 1166130013756 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 1166130013757 putative catalytic site [active] 1166130013758 putative metal binding site [ion binding]; other site 1166130013759 putative phosphate binding site [ion binding]; other site 1166130013760 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 1166130013761 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1166130013762 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1166130013763 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1166130013764 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1166130013765 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1166130013766 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1166130013767 Walker A/P-loop; other site 1166130013768 ATP binding site [chemical binding]; other site 1166130013769 Q-loop/lid; other site 1166130013770 ABC transporter signature motif; other site 1166130013771 Walker B; other site 1166130013772 D-loop; other site 1166130013773 H-loop/switch region; other site 1166130013774 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1166130013775 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1166130013776 Walker A/P-loop; other site 1166130013777 ATP binding site [chemical binding]; other site 1166130013778 Q-loop/lid; other site 1166130013779 ABC transporter signature motif; other site 1166130013780 Walker B; other site 1166130013781 D-loop; other site 1166130013782 H-loop/switch region; other site 1166130013783 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1166130013784 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1166130013785 HlyD family secretion protein; Region: HlyD_3; pfam13437 1166130013786 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 1166130013787 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1166130013788 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 1166130013789 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1166130013790 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1166130013791 ATP binding site [chemical binding]; other site 1166130013792 Mg++ binding site [ion binding]; other site 1166130013793 motif III; other site 1166130013794 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1166130013795 nucleotide binding region [chemical binding]; other site 1166130013796 ATP-binding site [chemical binding]; other site 1166130013797 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1166130013798 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1166130013799 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1166130013800 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1166130013801 beta-galactosidase; Region: BGL; TIGR03356 1166130013802 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1166130013803 beta-galactosidase; Region: BGL; TIGR03356 1166130013804 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1166130013805 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1166130013806 active site turn [active] 1166130013807 phosphorylation site [posttranslational modification] 1166130013808 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1166130013809 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1166130013810 HPr interaction site; other site 1166130013811 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1166130013812 active site 1166130013813 phosphorylation site [posttranslational modification] 1166130013814 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1166130013815 CAT RNA binding domain; Region: CAT_RBD; smart01061 1166130013816 PRD domain; Region: PRD; pfam00874 1166130013817 PRD domain; Region: PRD; pfam00874 1166130013818 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 1166130013819 DEAD_2; Region: DEAD_2; pfam06733 1166130013820 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1166130013821 glycosyl transferase family protein; Provisional; Region: PRK08136 1166130013822 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1166130013823 hypothetical protein; Provisional; Region: PRK10259 1166130013824 hypothetical protein; Provisional; Region: PRK11019 1166130013825 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1166130013826 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 1166130013827 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166130013828 S-adenosylmethionine binding site [chemical binding]; other site 1166130013829 putative mechanosensitive channel protein; Provisional; Region: PRK11465 1166130013830 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1166130013831 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 1166130013832 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1166130013833 Walker A/P-loop; other site 1166130013834 ATP binding site [chemical binding]; other site 1166130013835 Q-loop/lid; other site 1166130013836 ABC transporter signature motif; other site 1166130013837 Walker B; other site 1166130013838 D-loop; other site 1166130013839 H-loop/switch region; other site 1166130013840 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1166130013841 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130013842 dimer interface [polypeptide binding]; other site 1166130013843 conserved gate region; other site 1166130013844 putative PBP binding loops; other site 1166130013845 ABC-ATPase subunit interface; other site 1166130013846 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 1166130013847 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166130013848 substrate binding pocket [chemical binding]; other site 1166130013849 membrane-bound complex binding site; other site 1166130013850 hinge residues; other site 1166130013851 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1166130013852 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1166130013853 dimerization interface [polypeptide binding]; other site 1166130013854 DPS ferroxidase diiron center [ion binding]; other site 1166130013855 ion pore; other site 1166130013856 threonine and homoserine efflux system; Provisional; Region: PRK10532 1166130013857 EamA-like transporter family; Region: EamA; pfam00892 1166130013858 outer membrane protein X; Provisional; Region: ompX; PRK09408 1166130013859 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 1166130013860 Sulfatase; Region: Sulfatase; pfam00884 1166130013861 manganese transport regulator MntR; Provisional; Region: PRK11050 1166130013862 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1166130013863 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1166130013864 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1166130013865 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 1166130013866 transmembrane helices; other site 1166130013867 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1166130013868 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1166130013869 HlyD family secretion protein; Region: HlyD_3; pfam13437 1166130013870 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130013871 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1166130013872 putative substrate translocation pore; other site 1166130013873 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130013874 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1166130013875 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1166130013876 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1166130013877 active site 1166130013878 catalytic tetrad [active] 1166130013879 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1166130013880 beta-galactosidase; Region: BGL; TIGR03356 1166130013881 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1166130013882 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1166130013883 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1166130013884 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166130013885 DNA-binding site [nucleotide binding]; DNA binding site 1166130013886 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1166130013887 L,D-transpeptidase; Provisional; Region: PRK10260 1166130013888 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1166130013889 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1166130013890 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1166130013891 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166130013892 Walker A/P-loop; other site 1166130013893 ATP binding site [chemical binding]; other site 1166130013894 ABC transporter signature motif; other site 1166130013895 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1166130013896 Walker B; other site 1166130013897 ABC transporter; Region: ABC_tran_2; pfam12848 1166130013898 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1166130013899 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1166130013900 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1166130013901 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 1166130013902 putative active site [active] 1166130013903 putative catalytic site [active] 1166130013904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130013905 D-galactonate transporter; Region: 2A0114; TIGR00893 1166130013906 putative substrate translocation pore; other site 1166130013907 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1166130013908 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1166130013909 DNA binding site [nucleotide binding] 1166130013910 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1166130013911 ligand binding site [chemical binding]; other site 1166130013912 dimerization interface [polypeptide binding]; other site 1166130013913 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 1166130013914 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1166130013915 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1166130013916 active site 1166130013917 motif I; other site 1166130013918 motif II; other site 1166130013919 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1166130013920 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 1166130013921 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 1166130013922 dimer interface [polypeptide binding]; other site 1166130013923 active site 1166130013924 glycine loop; other site 1166130013925 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 1166130013926 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1166130013927 FeS/SAM binding site; other site 1166130013928 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1166130013929 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1166130013930 ATP binding site [chemical binding]; other site 1166130013931 substrate interface [chemical binding]; other site 1166130013932 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 1166130013933 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1166130013934 dimer interface [polypeptide binding]; other site 1166130013935 putative functional site; other site 1166130013936 putative MPT binding site; other site 1166130013937 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 1166130013938 catalytic nucleophile [active] 1166130013939 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1166130013940 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1166130013941 Walker A/P-loop; other site 1166130013942 ATP binding site [chemical binding]; other site 1166130013943 Q-loop/lid; other site 1166130013944 ABC transporter signature motif; other site 1166130013945 Walker B; other site 1166130013946 D-loop; other site 1166130013947 H-loop/switch region; other site 1166130013948 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1166130013949 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1166130013950 Walker A/P-loop; other site 1166130013951 ATP binding site [chemical binding]; other site 1166130013952 Q-loop/lid; other site 1166130013953 ABC transporter signature motif; other site 1166130013954 Walker B; other site 1166130013955 D-loop; other site 1166130013956 H-loop/switch region; other site 1166130013957 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1166130013958 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 1166130013959 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 1166130013960 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 1166130013961 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130013962 dimer interface [polypeptide binding]; other site 1166130013963 conserved gate region; other site 1166130013964 putative PBP binding loops; other site 1166130013965 ABC-ATPase subunit interface; other site 1166130013966 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 1166130013967 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1166130013968 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130013969 dimer interface [polypeptide binding]; other site 1166130013970 conserved gate region; other site 1166130013971 putative PBP binding loops; other site 1166130013972 ABC-ATPase subunit interface; other site 1166130013973 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 1166130013974 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1166130013975 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1166130013976 FeS/SAM binding site; other site 1166130013977 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1166130013978 MarR family; Region: MarR_2; pfam12802 1166130013979 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166130013980 Coenzyme A binding pocket [chemical binding]; other site 1166130013981 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1166130013982 active site 1166130013983 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1166130013984 Putative esterase; Region: Esterase; pfam00756 1166130013985 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166130013986 Coenzyme A binding pocket [chemical binding]; other site 1166130013987 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683 1166130013988 nudix motif; other site 1166130013989 Src homology 3 domains; Region: SH3; smart00326 1166130013990 peptide ligand binding site [polypeptide binding]; other site 1166130013991 Src Homology 3 domain superfamily; Region: SH3; cd00174 1166130013992 peptide ligand binding site [polypeptide binding]; other site 1166130013993 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1166130013994 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1166130013995 putative C-terminal domain interface [polypeptide binding]; other site 1166130013996 putative GSH binding site (G-site) [chemical binding]; other site 1166130013997 putative dimer interface [polypeptide binding]; other site 1166130013998 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 1166130013999 putative N-terminal domain interface [polypeptide binding]; other site 1166130014000 putative dimer interface [polypeptide binding]; other site 1166130014001 putative substrate binding pocket (H-site) [chemical binding]; other site 1166130014002 Biofilm formation protein (YliH/bssR); Region: YliH; cl08211 1166130014003 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1166130014004 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1166130014005 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 1166130014006 flagellin; Provisional; Region: PRK12802 1166130014007 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1166130014008 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1166130014009 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130014010 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1166130014011 dimerization interface [polypeptide binding]; other site 1166130014012 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1166130014013 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1166130014014 putative C-terminal domain interface [polypeptide binding]; other site 1166130014015 putative GSH binding site (G-site) [chemical binding]; other site 1166130014016 putative dimer interface [polypeptide binding]; other site 1166130014017 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 1166130014018 putative N-terminal domain interface [polypeptide binding]; other site 1166130014019 putative dimer interface [polypeptide binding]; other site 1166130014020 putative substrate binding pocket (H-site) [chemical binding]; other site 1166130014021 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 1166130014022 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1166130014023 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1166130014024 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 1166130014025 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1166130014026 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1166130014027 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1166130014028 active site 1166130014029 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1166130014030 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 1166130014031 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130014032 putative substrate translocation pore; other site 1166130014033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130014034 putative substrate translocation pore; other site 1166130014035 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1166130014036 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1166130014037 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 1166130014038 putative transporter; Provisional; Region: PRK04972 1166130014039 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1166130014040 TrkA-C domain; Region: TrkA_C; pfam02080 1166130014041 TrkA-C domain; Region: TrkA_C; pfam02080 1166130014042 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1166130014043 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 1166130014044 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 1166130014045 GSH binding site [chemical binding]; other site 1166130014046 catalytic residues [active] 1166130014047 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1166130014048 dimer interface [polypeptide binding]; other site 1166130014049 FMN binding site [chemical binding]; other site 1166130014050 NADPH bind site [chemical binding]; other site 1166130014051 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1166130014052 RimK-like ATP-grasp domain; Region: RimK; pfam08443 1166130014053 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1166130014054 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1166130014055 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1166130014056 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 1166130014057 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166130014058 Walker A/P-loop; other site 1166130014059 ATP binding site [chemical binding]; other site 1166130014060 Q-loop/lid; other site 1166130014061 ABC transporter signature motif; other site 1166130014062 Walker B; other site 1166130014063 D-loop; other site 1166130014064 H-loop/switch region; other site 1166130014065 TOBE domain; Region: TOBE_2; pfam08402 1166130014066 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1166130014067 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130014068 dimer interface [polypeptide binding]; other site 1166130014069 conserved gate region; other site 1166130014070 putative PBP binding loops; other site 1166130014071 ABC-ATPase subunit interface; other site 1166130014072 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1166130014073 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130014074 dimer interface [polypeptide binding]; other site 1166130014075 conserved gate region; other site 1166130014076 putative PBP binding loops; other site 1166130014077 ABC-ATPase subunit interface; other site 1166130014078 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 1166130014079 23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522 1166130014080 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166130014081 S-adenosylmethionine binding site [chemical binding]; other site 1166130014082 putative oxidoreductase; Provisional; Region: PRK09939 1166130014083 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1166130014084 putative molybdopterin cofactor binding site [chemical binding]; other site 1166130014085 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1166130014086 putative molybdopterin cofactor binding site; other site 1166130014087 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1166130014088 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166130014089 substrate binding pocket [chemical binding]; other site 1166130014090 membrane-bound complex binding site; other site 1166130014091 hinge residues; other site 1166130014092 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130014093 dimer interface [polypeptide binding]; other site 1166130014094 conserved gate region; other site 1166130014095 putative PBP binding loops; other site 1166130014096 ABC-ATPase subunit interface; other site 1166130014097 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1166130014098 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130014099 dimer interface [polypeptide binding]; other site 1166130014100 conserved gate region; other site 1166130014101 putative PBP binding loops; other site 1166130014102 ABC-ATPase subunit interface; other site 1166130014103 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1166130014104 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166130014105 substrate binding pocket [chemical binding]; other site 1166130014106 membrane-bound complex binding site; other site 1166130014107 hinge residues; other site 1166130014108 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 1166130014109 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166130014110 Walker A/P-loop; other site 1166130014111 ATP binding site [chemical binding]; other site 1166130014112 Q-loop/lid; other site 1166130014113 ABC transporter signature motif; other site 1166130014114 Walker B; other site 1166130014115 D-loop; other site 1166130014116 H-loop/switch region; other site 1166130014117 putative lipoprotein; Provisional; Region: PRK10533 1166130014118 hypothetical protein; Provisional; Region: PRK02877 1166130014119 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1166130014120 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1166130014121 amidase catalytic site [active] 1166130014122 Zn binding residues [ion binding]; other site 1166130014123 substrate binding site [chemical binding]; other site 1166130014124 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1166130014125 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1166130014126 NAD(P) binding site [chemical binding]; other site 1166130014127 active site 1166130014128 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1166130014129 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 1166130014130 putative NAD(P) binding site [chemical binding]; other site 1166130014131 putative active site [active] 1166130014132 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1166130014133 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1166130014134 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1166130014135 tetramer interface [polypeptide binding]; other site 1166130014136 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130014137 catalytic residue [active] 1166130014138 pyruvate dehydrogenase; Provisional; Region: PRK09124 1166130014139 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1166130014140 PYR/PP interface [polypeptide binding]; other site 1166130014141 dimer interface [polypeptide binding]; other site 1166130014142 tetramer interface [polypeptide binding]; other site 1166130014143 TPP binding site [chemical binding]; other site 1166130014144 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1166130014145 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1166130014146 TPP-binding site [chemical binding]; other site 1166130014147 Predicted membrane protein [Function unknown]; Region: COG2259 1166130014148 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 1166130014149 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 1166130014150 FAD binding pocket [chemical binding]; other site 1166130014151 FAD binding motif [chemical binding]; other site 1166130014152 phosphate binding motif [ion binding]; other site 1166130014153 beta-alpha-beta structure motif; other site 1166130014154 NAD binding pocket [chemical binding]; other site 1166130014155 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1166130014156 catalytic loop [active] 1166130014157 iron binding site [ion binding]; other site 1166130014158 hybrid cluster protein; Provisional; Region: PRK05290 1166130014159 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1166130014160 ACS interaction site; other site 1166130014161 CODH interaction site; other site 1166130014162 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 1166130014163 hybrid metal cluster; other site 1166130014164 Predicted membrane protein [Function unknown]; Region: COG2431 1166130014165 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1166130014166 amphipathic channel; other site 1166130014167 Asn-Pro-Ala signature motifs; other site 1166130014168 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 1166130014169 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 1166130014170 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1166130014171 putative active site [active] 1166130014172 putative metal-binding site [ion binding]; other site 1166130014173 Protein of unknown function (DUF535); Region: DUF535; cl01128 1166130014174 macrolide transporter subunit MacA; Provisional; Region: PRK11578 1166130014175 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1166130014176 HlyD family secretion protein; Region: HlyD_3; pfam13437 1166130014177 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 1166130014178 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1166130014179 Walker A/P-loop; other site 1166130014180 ATP binding site [chemical binding]; other site 1166130014181 Q-loop/lid; other site 1166130014182 ABC transporter signature motif; other site 1166130014183 Walker B; other site 1166130014184 D-loop; other site 1166130014185 H-loop/switch region; other site 1166130014186 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1166130014187 FtsX-like permease family; Region: FtsX; pfam02687 1166130014188 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1166130014189 DNA-binding site [nucleotide binding]; DNA binding site 1166130014190 RNA-binding motif; other site 1166130014191 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1166130014192 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 1166130014193 Clp amino terminal domain; Region: Clp_N; pfam02861 1166130014194 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166130014195 Walker A motif; other site 1166130014196 ATP binding site [chemical binding]; other site 1166130014197 Walker B motif; other site 1166130014198 arginine finger; other site 1166130014199 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166130014200 Walker A motif; other site 1166130014201 ATP binding site [chemical binding]; other site 1166130014202 Walker B motif; other site 1166130014203 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1166130014204 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1166130014205 heme-binding site [chemical binding]; other site 1166130014206 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1166130014207 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166130014208 metal binding site [ion binding]; metal-binding site 1166130014209 active site 1166130014210 I-site; other site 1166130014211 RES domain; Region: RES; cl02411 1166130014212 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 1166130014213 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 1166130014214 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1166130014215 rRNA binding site [nucleotide binding]; other site 1166130014216 predicted 30S ribosome binding site; other site 1166130014217 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1166130014218 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 1166130014219 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1166130014220 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166130014221 Walker A/P-loop; other site 1166130014222 ATP binding site [chemical binding]; other site 1166130014223 Q-loop/lid; other site 1166130014224 ABC transporter signature motif; other site 1166130014225 Walker B; other site 1166130014226 D-loop; other site 1166130014227 H-loop/switch region; other site 1166130014228 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 1166130014229 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1166130014230 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166130014231 Walker A/P-loop; other site 1166130014232 ATP binding site [chemical binding]; other site 1166130014233 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166130014234 Q-loop/lid; other site 1166130014235 Q-loop/lid; other site 1166130014236 ABC transporter signature motif; other site 1166130014237 Walker B; other site 1166130014238 D-loop; other site 1166130014239 H-loop/switch region; other site 1166130014240 thioredoxin reductase; Provisional; Region: PRK10262 1166130014241 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1166130014242 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1166130014243 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1166130014244 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1166130014245 putative DNA binding site [nucleotide binding]; other site 1166130014246 putative Zn2+ binding site [ion binding]; other site 1166130014247 AsnC family; Region: AsnC_trans_reg; pfam01037 1166130014248 DNA translocase FtsK; Provisional; Region: PRK10263 1166130014249 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1166130014250 DNA translocase FtsK; Provisional; Region: PRK10263 1166130014251 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1166130014252 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1166130014253 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 1166130014254 periplasmic chaperone LolA; Region: lolA; TIGR00547 1166130014255 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1166130014256 recombination factor protein RarA; Reviewed; Region: PRK13342 1166130014257 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166130014258 Walker A motif; other site 1166130014259 ATP binding site [chemical binding]; other site 1166130014260 Walker B motif; other site 1166130014261 arginine finger; other site 1166130014262 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1166130014263 seryl-tRNA synthetase; Provisional; Region: PRK05431 1166130014264 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1166130014265 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1166130014266 dimer interface [polypeptide binding]; other site 1166130014267 active site 1166130014268 motif 1; other site 1166130014269 motif 2; other site 1166130014270 motif 3; other site 1166130014271 putative MFS family transporter protein; Provisional; Region: PRK03633 1166130014272 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130014273 putative substrate translocation pore; other site 1166130014274 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 1166130014275 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1166130014276 FeS/SAM binding site; other site 1166130014277 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1166130014278 Pyruvate formate lyase 1; Region: PFL1; cd01678 1166130014279 coenzyme A binding site [chemical binding]; other site 1166130014280 active site 1166130014281 catalytic residues [active] 1166130014282 glycine loop; other site 1166130014283 formate transporter; Provisional; Region: PRK10805 1166130014284 uncharacterized domain; Region: TIGR00702 1166130014285 YcaO-like family; Region: YcaO; pfam02624 1166130014286 Predicted membrane protein [Function unknown]; Region: COG2323 1166130014287 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1166130014288 homodimer interface [polypeptide binding]; other site 1166130014289 substrate-cofactor binding pocket; other site 1166130014290 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130014291 catalytic residue [active] 1166130014292 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1166130014293 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1166130014294 hinge; other site 1166130014295 active site 1166130014296 cytidylate kinase; Provisional; Region: cmk; PRK00023 1166130014297 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1166130014298 CMP-binding site; other site 1166130014299 The sites determining sugar specificity; other site 1166130014300 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1166130014301 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1166130014302 RNA binding site [nucleotide binding]; other site 1166130014303 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1166130014304 RNA binding site [nucleotide binding]; other site 1166130014305 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 1166130014306 RNA binding site [nucleotide binding]; other site 1166130014307 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 1166130014308 RNA binding site [nucleotide binding]; other site 1166130014309 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1166130014310 RNA binding site [nucleotide binding]; other site 1166130014311 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1166130014312 IHF dimer interface [polypeptide binding]; other site 1166130014313 IHF - DNA interface [nucleotide binding]; other site 1166130014314 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1166130014315 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 1166130014316 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1166130014317 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1166130014318 Walker A/P-loop; other site 1166130014319 ATP binding site [chemical binding]; other site 1166130014320 Q-loop/lid; other site 1166130014321 ABC transporter signature motif; other site 1166130014322 Walker B; other site 1166130014323 D-loop; other site 1166130014324 H-loop/switch region; other site 1166130014325 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1166130014326 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 1166130014327 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1166130014328 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1166130014329 Trm112p-like protein; Region: Trm112p; cl01066 1166130014330 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1166130014331 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1166130014332 Ligand binding site; other site 1166130014333 oligomer interface; other site 1166130014334 hypothetical protein; Provisional; Region: PRK10593 1166130014335 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1166130014336 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1166130014337 putative active site [active] 1166130014338 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1166130014339 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166130014340 S-adenosylmethionine binding site [chemical binding]; other site 1166130014341 condesin subunit F; Provisional; Region: PRK05260 1166130014342 condesin subunit E; Provisional; Region: PRK05256 1166130014343 cell division protein MukB; Provisional; Region: mukB; PRK04863 1166130014344 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1166130014345 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1166130014346 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1166130014347 murein L,D-transpeptidase; Provisional; Region: PRK10594 1166130014348 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1166130014349 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1166130014350 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1166130014351 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 1166130014352 Peptidase M15; Region: Peptidase_M15_3; cl01194 1166130014353 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1166130014354 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1166130014355 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1166130014356 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130014357 homodimer interface [polypeptide binding]; other site 1166130014358 catalytic residue [active] 1166130014359 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1166130014360 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1166130014361 trimer interface [polypeptide binding]; other site 1166130014362 eyelet of channel; other site 1166130014363 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1166130014364 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1166130014365 putative dimer interface [polypeptide binding]; other site 1166130014366 putative anticodon binding site; other site 1166130014367 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1166130014368 homodimer interface [polypeptide binding]; other site 1166130014369 motif 1; other site 1166130014370 motif 2; other site 1166130014371 active site 1166130014372 motif 3; other site 1166130014373 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 1166130014374 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 1166130014375 active site 1166130014376 aminopeptidase N; Provisional; Region: pepN; PRK14015 1166130014377 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 1166130014378 active site 1166130014379 Zn binding site [ion binding]; other site 1166130014380 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 1166130014381 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1166130014382 Walker A/P-loop; other site 1166130014383 ATP binding site [chemical binding]; other site 1166130014384 Q-loop/lid; other site 1166130014385 ABC transporter signature motif; other site 1166130014386 Walker B; other site 1166130014387 D-loop; other site 1166130014388 H-loop/switch region; other site 1166130014389 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1166130014390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130014391 dimer interface [polypeptide binding]; other site 1166130014392 conserved gate region; other site 1166130014393 putative PBP binding loops; other site 1166130014394 ABC-ATPase subunit interface; other site 1166130014395 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1166130014396 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1166130014397 active site 1166130014398 dimer interface [polypeptide binding]; other site 1166130014399 non-prolyl cis peptide bond; other site 1166130014400 insertion regions; other site 1166130014401 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1166130014402 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166130014403 substrate binding pocket [chemical binding]; other site 1166130014404 membrane-bound complex binding site; other site 1166130014405 hinge residues; other site 1166130014406 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 1166130014407 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1166130014408 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1166130014409 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1166130014410 quinone interaction residues [chemical binding]; other site 1166130014411 active site 1166130014412 catalytic residues [active] 1166130014413 FMN binding site [chemical binding]; other site 1166130014414 substrate binding site [chemical binding]; other site 1166130014415 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 1166130014416 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1166130014417 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1166130014418 MOSC domain; Region: MOSC; pfam03473 1166130014419 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1166130014420 catalytic loop [active] 1166130014421 iron binding site [ion binding]; other site 1166130014422 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 1166130014423 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1166130014424 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166130014425 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166130014426 S-adenosylmethionine binding site [chemical binding]; other site 1166130014427 ABC transporter ATPase component; Reviewed; Region: PRK11147 1166130014428 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166130014429 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166130014430 Walker A/P-loop; other site 1166130014431 Walker A/P-loop; other site 1166130014432 ATP binding site [chemical binding]; other site 1166130014433 ATP binding site [chemical binding]; other site 1166130014434 Q-loop/lid; other site 1166130014435 Q-loop/lid; other site 1166130014436 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1166130014437 ABC transporter signature motif; other site 1166130014438 Walker B; other site 1166130014439 D-loop; other site 1166130014440 ABC transporter; Region: ABC_tran_2; pfam12848 1166130014441 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1166130014442 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 1166130014443 Paraquat-inducible protein A; Region: PqiA; pfam04403 1166130014444 Paraquat-inducible protein A; Region: PqiA; pfam04403 1166130014445 paraquat-inducible protein B; Provisional; Region: PRK10807 1166130014446 mce related protein; Region: MCE; pfam02470 1166130014447 mce related protein; Region: MCE; pfam02470 1166130014448 mce related protein; Region: MCE; pfam02470 1166130014449 Biogenesis of lysosome-related organelles complex-1 subunit 2; Region: BLOC1_2; pfam10046 1166130014450 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 1166130014451 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1166130014452 ribosome modulation factor; Provisional; Region: PRK14563 1166130014453 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 1166130014454 active site 1 [active] 1166130014455 dimer interface [polypeptide binding]; other site 1166130014456 active site 2 [active] 1166130014457 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 1166130014458 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1166130014459 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 1166130014460 outer membrane protein A; Reviewed; Region: PRK10808 1166130014461 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 1166130014462 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1166130014463 ligand binding site [chemical binding]; other site 1166130014464 SOS cell division inhibitor; Provisional; Region: PRK10595 1166130014465 TfoX N-terminal domain; Region: TfoX_N; pfam04993 1166130014466 TfoX C-terminal domain; Region: TfoX_C; pfam04994 1166130014467 TIGR01666 family membrane protein; Region: YCCS 1166130014468 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1166130014469 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1166130014470 Predicted membrane protein [Function unknown]; Region: COG3304 1166130014471 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1166130014472 DNA helicase IV; Provisional; Region: helD; PRK11054 1166130014473 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 1166130014474 Part of AAA domain; Region: AAA_19; pfam13245 1166130014475 Family description; Region: UvrD_C_2; pfam13538 1166130014476 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1166130014477 active site 1166130014478 dimer interfaces [polypeptide binding]; other site 1166130014479 catalytic residues [active] 1166130014480 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1166130014481 heat shock protein HspQ; Provisional; Region: PRK14129 1166130014482 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 1166130014483 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 1166130014484 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1166130014485 putative RNA binding site [nucleotide binding]; other site 1166130014486 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166130014487 S-adenosylmethionine binding site [chemical binding]; other site 1166130014488 acylphosphatase; Provisional; Region: PRK14426 1166130014489 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 1166130014490 sulfur transfer protein TusE; Provisional; Region: PRK11508 1166130014491 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1166130014492 YccA-like proteins; Region: YccA_like; cd10433 1166130014493 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1166130014494 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1166130014495 peptide binding site [polypeptide binding]; other site 1166130014496 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 1166130014497 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1166130014498 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1166130014499 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 1166130014500 Phosphopantetheinyl transferase (holo-ACP synthase) [Lipid metabolism]; Region: AcpS; COG0736 1166130014501 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1166130014502 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1166130014503 NAD(P) binding site [chemical binding]; other site 1166130014504 active site 1166130014505 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases [Lipid metabolism]; Region: FabA; COG0764 1166130014506 active site 2 [active] 1166130014507 active site 1 [active] 1166130014508 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1166130014509 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 1166130014510 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1166130014511 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1166130014512 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1166130014513 dimer interface [polypeptide binding]; other site 1166130014514 active site 1166130014515 polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103 1166130014516 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1166130014517 active site 1166130014518 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1166130014519 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1166130014520 active site 1166130014521 aminotransferase AlaT; Validated; Region: PRK09265 1166130014522 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1166130014523 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1166130014524 Walker A/P-loop; other site 1166130014525 ATP binding site [chemical binding]; other site 1166130014526 Q-loop/lid; other site 1166130014527 ABC transporter signature motif; other site 1166130014528 Walker B; other site 1166130014529 D-loop; other site 1166130014530 H-loop/switch region; other site 1166130014531 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1166130014532 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1166130014533 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1166130014534 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1166130014535 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1166130014536 DNA binding residues [nucleotide binding] 1166130014537 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1166130014538 heme-binding site [chemical binding]; other site 1166130014539 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1166130014540 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166130014541 metal binding site [ion binding]; metal-binding site 1166130014542 active site 1166130014543 I-site; other site 1166130014544 Uncharacterized protein family (UPF0257); Region: UPF0257; cl14672 1166130014545 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1166130014546 classical (c) SDRs; Region: SDR_c; cd05233 1166130014547 NAD(P) binding site [chemical binding]; other site 1166130014548 active site 1166130014549 Predicted transcriptional regulators [Transcription]; Region: COG1733 1166130014550 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1166130014551 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 1166130014552 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1166130014553 catalytic core [active] 1166130014554 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1166130014555 hypothetical protein; Provisional; Region: PRK10174 1166130014556 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 1166130014557 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1166130014558 General stress protein [General function prediction only]; Region: GsiB; COG3729 1166130014559 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 1166130014560 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1166130014561 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1166130014562 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 1166130014563 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 1166130014564 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 1166130014565 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1166130014566 ligand binding site [chemical binding]; other site 1166130014567 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1166130014568 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1166130014569 Walker A/P-loop; other site 1166130014570 ATP binding site [chemical binding]; other site 1166130014571 Q-loop/lid; other site 1166130014572 ABC transporter signature motif; other site 1166130014573 Walker B; other site 1166130014574 D-loop; other site 1166130014575 H-loop/switch region; other site 1166130014576 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1166130014577 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1166130014578 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1166130014579 TM-ABC transporter signature motif; other site 1166130014580 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1166130014581 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1166130014582 TM-ABC transporter signature motif; other site 1166130014583 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 1166130014584 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 1166130014585 N- and C-terminal domain interface [polypeptide binding]; other site 1166130014586 active site 1166130014587 MgATP binding site [chemical binding]; other site 1166130014588 catalytic site [active] 1166130014589 metal binding site [ion binding]; metal-binding site 1166130014590 carbohydrate binding site [chemical binding]; other site 1166130014591 putative homodimer interface [polypeptide binding]; other site 1166130014592 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1166130014593 putative active site [active] 1166130014594 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 1166130014595 Predicted transcriptional regulator [Transcription]; Region: COG3905 1166130014596 Proline dehydrogenase; Region: Pro_dh; pfam01619 1166130014597 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1166130014598 Glutamate binding site [chemical binding]; other site 1166130014599 NAD binding site [chemical binding]; other site 1166130014600 catalytic residues [active] 1166130014601 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1166130014602 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1166130014603 Na binding site [ion binding]; other site 1166130014604 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 1166130014605 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1166130014606 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1166130014607 Nucleoside recognition; Region: Gate; pfam07670 1166130014608 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1166130014609 FTR1 family protein; Region: TIGR00145 1166130014610 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 1166130014611 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1166130014612 Imelysin; Region: Peptidase_M75; pfam09375 1166130014613 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1166130014614 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1166130014615 hypothetical protein; Provisional; Region: PRK10536 1166130014616 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1166130014617 Chorismate mutase type II; Region: CM_2; cl00693 1166130014618 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1166130014619 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 1166130014620 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1166130014621 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130014622 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1166130014623 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1166130014624 HlyD family secretion protein; Region: HlyD_3; pfam13437 1166130014625 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1166130014626 Predicted transcriptional regulator [Transcription]; Region: COG1959 1166130014627 Transcriptional regulator; Region: Rrf2; pfam02082 1166130014628 Transcriptional regulator; Region: Rrf2; cl17282 1166130014629 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1166130014630 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1166130014631 NAD(P) binding site [chemical binding]; other site 1166130014632 active site 1166130014633 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166130014634 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130014635 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1166130014636 putative effector binding pocket; other site 1166130014637 putative dimerization interface [polypeptide binding]; other site 1166130014638 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144 1166130014639 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1166130014640 conserved cys residue [active] 1166130014641 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 1166130014642 ligand binding site [chemical binding]; other site 1166130014643 dimer interface [polypeptide binding]; other site 1166130014644 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1166130014645 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1166130014646 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 1166130014647 homotrimer interaction site [polypeptide binding]; other site 1166130014648 putative active site [active] 1166130014649 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1166130014650 hydrophobic ligand binding site; other site 1166130014651 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 1166130014652 dimerization interface [polypeptide binding]; other site 1166130014653 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1166130014654 NAD binding site [chemical binding]; other site 1166130014655 ligand binding site [chemical binding]; other site 1166130014656 catalytic site [active] 1166130014657 short chain dehydrogenase; Provisional; Region: PRK06500 1166130014658 classical (c) SDRs; Region: SDR_c; cd05233 1166130014659 NAD(P) binding site [chemical binding]; other site 1166130014660 active site 1166130014661 Predicted transcriptional regulators [Transcription]; Region: COG1733 1166130014662 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1166130014663 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1166130014664 C factor cell-cell signaling protein; Provisional; Region: PRK09009 1166130014665 NAD(P) binding site [chemical binding]; other site 1166130014666 active site 1166130014667 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1166130014668 classical (c) SDRs; Region: SDR_c; cd05233 1166130014669 NAD(P) binding site [chemical binding]; other site 1166130014670 active site 1166130014671 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1166130014672 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130014673 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1166130014674 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1166130014675 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 1166130014676 active site 1166130014677 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1166130014678 dimer interface [polypeptide binding]; other site 1166130014679 substrate binding site [chemical binding]; other site 1166130014680 catalytic residue [active] 1166130014681 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1166130014682 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1166130014683 Walker A/P-loop; other site 1166130014684 ATP binding site [chemical binding]; other site 1166130014685 Q-loop/lid; other site 1166130014686 ABC transporter signature motif; other site 1166130014687 Walker B; other site 1166130014688 D-loop; other site 1166130014689 H-loop/switch region; other site 1166130014690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130014691 dimer interface [polypeptide binding]; other site 1166130014692 conserved gate region; other site 1166130014693 putative PBP binding loops; other site 1166130014694 ABC-ATPase subunit interface; other site 1166130014695 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1166130014696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130014697 dimer interface [polypeptide binding]; other site 1166130014698 conserved gate region; other site 1166130014699 putative PBP binding loops; other site 1166130014700 ABC-ATPase subunit interface; other site 1166130014701 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1166130014702 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166130014703 substrate binding pocket [chemical binding]; other site 1166130014704 membrane-bound complex binding site; other site 1166130014705 hinge residues; other site 1166130014706 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1166130014707 homotrimer interaction site [polypeptide binding]; other site 1166130014708 putative active site [active] 1166130014709 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1166130014710 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1166130014711 Bacterial transcriptional regulator; Region: IclR; pfam01614 1166130014712 S-methylmethionine transporter; Provisional; Region: PRK11387 1166130014713 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1166130014714 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1166130014715 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1166130014716 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1166130014717 putative NAD(P) binding site [chemical binding]; other site 1166130014718 RibD C-terminal domain; Region: RibD_C; cl17279 1166130014719 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1166130014720 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166130014721 Coenzyme A binding pocket [chemical binding]; other site 1166130014722 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166130014723 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130014724 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1166130014725 putative effector binding pocket; other site 1166130014726 dimerization interface [polypeptide binding]; other site 1166130014727 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1166130014728 NmrA-like family; Region: NmrA; pfam05368 1166130014729 NAD(P) binding site [chemical binding]; other site 1166130014730 active site 1166130014731 Cupin; Region: Cupin_6; pfam12852 1166130014732 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1166130014733 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130014734 short chain dehydrogenase; Validated; Region: PRK06182 1166130014735 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1166130014736 NADP binding site [chemical binding]; other site 1166130014737 active site 1166130014738 steroid binding site; other site 1166130014739 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130014740 putative substrate translocation pore; other site 1166130014741 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1166130014742 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1166130014743 NAD(P) binding site [chemical binding]; other site 1166130014744 active site 1166130014745 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166130014746 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130014747 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1166130014748 dimerization interface [polypeptide binding]; other site 1166130014749 MltA-interacting protein MipA; Region: MipA; cl01504 1166130014750 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1166130014751 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130014752 active site 1166130014753 phosphorylation site [posttranslational modification] 1166130014754 intermolecular recognition site; other site 1166130014755 dimerization interface [polypeptide binding]; other site 1166130014756 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1166130014757 DNA binding site [nucleotide binding] 1166130014758 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1166130014759 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1166130014760 dimer interface [polypeptide binding]; other site 1166130014761 phosphorylation site [posttranslational modification] 1166130014762 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166130014763 ATP binding site [chemical binding]; other site 1166130014764 Mg2+ binding site [ion binding]; other site 1166130014765 G-X-G motif; other site 1166130014766 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 1166130014767 RNAase interaction site [polypeptide binding]; other site 1166130014768 chloramphenicol acetyltransferase; Provisional; Region: PRK13757 1166130014769 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 1166130014770 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 1166130014771 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1166130014772 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166130014773 Coenzyme A binding pocket [chemical binding]; other site 1166130014774 classical (c) SDRs; Region: SDR_c; cd05233 1166130014775 NAD(P) binding site [chemical binding]; other site 1166130014776 active site 1166130014777 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1166130014778 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1166130014779 putative transcriptional regulator; Provisional; Region: PRK11640 1166130014780 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1166130014781 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 1166130014782 SnoaL-like domain; Region: SnoaL_2; pfam12680 1166130014783 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1166130014784 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1166130014785 catalytic triad [active] 1166130014786 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1166130014787 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166130014788 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166130014789 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130014790 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1166130014791 putative effector binding pocket; other site 1166130014792 putative dimerization interface [polypeptide binding]; other site 1166130014793 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 1166130014794 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1166130014795 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1166130014796 NAD(P) binding site [chemical binding]; other site 1166130014797 active site 1166130014798 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1166130014799 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166130014800 dimer interface [polypeptide binding]; other site 1166130014801 putative CheW interface [polypeptide binding]; other site 1166130014802 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1166130014803 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1166130014804 NAD(P) binding site [chemical binding]; other site 1166130014805 active site 1166130014806 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166130014807 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130014808 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1166130014809 dimerization interface [polypeptide binding]; other site 1166130014810 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166130014811 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130014812 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1166130014813 putative effector binding pocket; other site 1166130014814 dimerization interface [polypeptide binding]; other site 1166130014815 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1166130014816 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1166130014817 putative NAD(P) binding site [chemical binding]; other site 1166130014818 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1166130014819 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 1166130014820 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 1166130014821 putative ligand binding site [chemical binding]; other site 1166130014822 NAD binding site [chemical binding]; other site 1166130014823 dimerization interface [polypeptide binding]; other site 1166130014824 catalytic site [active] 1166130014825 putative hydrolase; Validated; Region: PRK09248 1166130014826 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 1166130014827 active site 1166130014828 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 1166130014829 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 1166130014830 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 1166130014831 curli assembly protein CsgF; Provisional; Region: PRK10050 1166130014832 curli assembly protein CsgE; Provisional; Region: PRK10386 1166130014833 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 1166130014834 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1166130014835 DNA binding residues [nucleotide binding] 1166130014836 dimerization interface [polypeptide binding]; other site 1166130014837 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 1166130014838 Curlin associated repeat; Region: Curlin_rpt; pfam07012 1166130014839 Curlin associated repeat; Region: Curlin_rpt; pfam07012 1166130014840 major curlin subunit; Provisional; Region: csgA; PRK10051 1166130014841 Curlin associated repeat; Region: Curlin_rpt; pfam07012 1166130014842 Thin aggregative fimbriae synthesis protein; Region: Tafi-CsgC; cl11667 1166130014843 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1166130014844 putative ADP-ribose binding site [chemical binding]; other site 1166130014845 putative active site [active] 1166130014846 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1166130014847 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1166130014848 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 1166130014849 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 1166130014850 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1166130014851 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 1166130014852 Ligand binding site; other site 1166130014853 DXD motif; other site 1166130014854 secY/secA suppressor protein; Provisional; Region: PRK11467 1166130014855 drug efflux system protein MdtG; Provisional; Region: PRK09874 1166130014856 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130014857 putative substrate translocation pore; other site 1166130014858 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1166130014859 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1166130014860 putative acyl-acceptor binding pocket; other site 1166130014861 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1166130014862 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1166130014863 active site residue [active] 1166130014864 hypothetical protein; Provisional; Region: PRK03757 1166130014865 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1166130014866 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 1166130014867 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1166130014868 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 1166130014869 DNA damage-inducible protein I; Provisional; Region: PRK10597 1166130014870 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1166130014871 active site 1166130014872 substrate binding pocket [chemical binding]; other site 1166130014873 dimer interface [polypeptide binding]; other site 1166130014874 lipoprotein; Provisional; Region: PRK10598 1166130014875 glutaredoxin 2; Provisional; Region: PRK10387 1166130014876 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 1166130014877 C-terminal domain interface [polypeptide binding]; other site 1166130014878 GSH binding site (G-site) [chemical binding]; other site 1166130014879 catalytic residues [active] 1166130014880 putative dimer interface [polypeptide binding]; other site 1166130014881 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 1166130014882 N-terminal domain interface [polypeptide binding]; other site 1166130014883 multidrug resistance protein MdtH; Provisional; Region: PRK11646 1166130014884 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130014885 putative substrate translocation pore; other site 1166130014886 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 1166130014887 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1166130014888 hypothetical protein; Provisional; Region: PRK11239 1166130014889 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 1166130014890 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1166130014891 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1166130014892 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1166130014893 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1166130014894 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 1166130014895 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 1166130014896 SAF-like; Region: SAF_2; pfam13144 1166130014897 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1166130014898 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 1166130014899 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1166130014900 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1166130014901 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1166130014902 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1166130014903 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1166130014904 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 1166130014905 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1166130014906 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1166130014907 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1166130014908 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1166130014909 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1166130014910 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1166130014911 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 1166130014912 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1166130014913 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1166130014914 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 1166130014915 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1166130014916 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1166130014917 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 1166130014918 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 1166130014919 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1166130014920 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1166130014921 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 1166130014922 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 1166130014923 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1166130014924 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 1166130014925 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1166130014926 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 1166130014927 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1166130014928 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1166130014929 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1166130014930 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166130014931 putative substrate translocation pore; other site 1166130014932 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166130014933 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166130014934 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1166130014935 putative effector binding pocket; other site 1166130014936 dimerization interface [polypeptide binding]; other site 1166130014937 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1166130014938 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1166130014939 homodimer interface [polypeptide binding]; other site 1166130014940 oligonucleotide binding site [chemical binding]; other site 1166130014941 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 1166130014942 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1166130014943 RNA binding surface [nucleotide binding]; other site 1166130014944 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1166130014945 active site 1166130014946 Abhydrolase family; Region: Abhydrolase_7; pfam12715 1166130014947 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1166130014948 Maf-like protein; Region: Maf; pfam02545 1166130014949 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1166130014950 active site 1166130014951 dimer interface [polypeptide binding]; other site 1166130014952 hypothetical protein; Provisional; Region: PRK11193 1166130014953 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1166130014954 putative phosphate acyltransferase; Provisional; Region: PRK05331 1166130014955 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1166130014956 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1166130014957 dimer interface [polypeptide binding]; other site 1166130014958 active site 1166130014959 CoA binding pocket [chemical binding]; other site 1166130014960 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1166130014961 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1166130014962 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1166130014963 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1166130014964 NAD(P) binding site [chemical binding]; other site 1166130014965 homotetramer interface [polypeptide binding]; other site 1166130014966 homodimer interface [polypeptide binding]; other site 1166130014967 active site 1166130014968 acyl carrier protein; Provisional; Region: acpP; PRK00982 1166130014969 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1166130014970 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1166130014971 dimer interface [polypeptide binding]; other site 1166130014972 active site 1166130014973 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1166130014974 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1166130014975 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166130014976 catalytic residue [active] 1166130014977 conserved hypothetical protein, YceG family; Region: TIGR00247 1166130014978 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1166130014979 dimerization interface [polypeptide binding]; other site 1166130014980 thymidylate kinase; Validated; Region: tmk; PRK00698 1166130014981 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1166130014982 TMP-binding site; other site 1166130014983 ATP-binding site [chemical binding]; other site 1166130014984 DNA polymerase III subunit delta'; Validated; Region: PRK07993 1166130014985 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 1166130014986 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1166130014987 active site 1166130014988 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 1166130014989 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1166130014990 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1166130014991 active site turn [active] 1166130014992 phosphorylation site [posttranslational modification] 1166130014993 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 1166130014994 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1166130014995 N-terminal plug; other site 1166130014996 ligand-binding site [chemical binding]; other site 1166130014997 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1166130014998 nucleotide binding site/active site [active] 1166130014999 HIT family signature motif; other site 1166130015000 catalytic residue [active] 1166130015001 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 1166130015002 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 1166130015003 putative dimer interface [polypeptide binding]; other site 1166130015004 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 1166130015005 thiamine kinase; Region: ycfN_thiK; TIGR02721 1166130015006 thiamine kinase; Provisional; Region: thiK; PRK10271 1166130015007 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1166130015008 beta-hexosaminidase; Provisional; Region: PRK05337 1166130015009 hypothetical protein; Provisional; Region: PRK04940 1166130015010 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1166130015011 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1166130015012 hypothetical protein; Provisional; Region: PRK11280 1166130015013 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1166130015014 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1166130015015 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1166130015016 L,D-transpeptidase; Provisional; Region: PRK10190 1166130015017 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1166130015018 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1166130015019 transcription-repair coupling factor; Provisional; Region: PRK10689 1166130015020 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1166130015021 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1166130015022 ATP binding site [chemical binding]; other site 1166130015023 putative Mg++ binding site [ion binding]; other site 1166130015024 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1166130015025 nucleotide binding region [chemical binding]; other site 1166130015026 ATP-binding site [chemical binding]; other site 1166130015027 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1166130015028 Predicted membrane protein [Function unknown]; Region: COG4763 1166130015029 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1166130015030 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 1166130015031 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1166130015032 FtsX-like permease family; Region: FtsX; pfam02687 1166130015033 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 1166130015034 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1166130015035 Walker A/P-loop; other site 1166130015036 ATP binding site [chemical binding]; other site 1166130015037 Q-loop/lid; other site 1166130015038 ABC transporter signature motif; other site 1166130015039 Walker B; other site 1166130015040 D-loop; other site 1166130015041 H-loop/switch region; other site 1166130015042 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 1166130015043 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1166130015044 FtsX-like permease family; Region: FtsX; pfam02687 1166130015045 fructokinase; Reviewed; Region: PRK09557 1166130015046 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1166130015047 nucleotide binding site [chemical binding]; other site 1166130015048 NAD-dependent deacetylase; Provisional; Region: PRK00481 1166130015049 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1166130015050 NAD+ binding site [chemical binding]; other site 1166130015051 substrate binding site [chemical binding]; other site 1166130015052 Zn binding site [ion binding]; other site 1166130015053 MltA-interacting protein MipA; Region: MipA; cl01504 1166130015054 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1166130015055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130015056 active site 1166130015057 phosphorylation site [posttranslational modification] 1166130015058 intermolecular recognition site; other site 1166130015059 dimerization interface [polypeptide binding]; other site 1166130015060 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1166130015061 DNA binding site [nucleotide binding] 1166130015062 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1166130015063 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1166130015064 dimerization interface [polypeptide binding]; other site 1166130015065 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166130015066 ATP binding site [chemical binding]; other site 1166130015067 Mg2+ binding site [ion binding]; other site 1166130015068 G-X-G motif; other site 1166130015069 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 1166130015070 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1166130015071 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1166130015072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130015073 dimer interface [polypeptide binding]; other site 1166130015074 conserved gate region; other site 1166130015075 putative PBP binding loops; other site 1166130015076 ABC-ATPase subunit interface; other site 1166130015077 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1166130015078 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166130015079 dimer interface [polypeptide binding]; other site 1166130015080 conserved gate region; other site 1166130015081 putative PBP binding loops; other site 1166130015082 ABC-ATPase subunit interface; other site 1166130015083 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 1166130015084 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166130015085 Walker A/P-loop; other site 1166130015086 ATP binding site [chemical binding]; other site 1166130015087 Q-loop/lid; other site 1166130015088 ABC transporter signature motif; other site 1166130015089 Walker B; other site 1166130015090 D-loop; other site 1166130015091 H-loop/switch region; other site 1166130015092 TOBE domain; Region: TOBE_2; pfam08402 1166130015093 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 1166130015094 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1166130015095 metal binding site [ion binding]; metal-binding site 1166130015096 dimer interface [polypeptide binding]; other site 1166130015097 Uncharacterized conserved protein [Function unknown]; Region: COG2850 1166130015098 Cupin-like domain; Region: Cupin_8; pfam13621 1166130015099 sensor protein PhoQ; Provisional; Region: PRK10815 1166130015100 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 1166130015101 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 1166130015102 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166130015103 ATP binding site [chemical binding]; other site 1166130015104 Mg2+ binding site [ion binding]; other site 1166130015105 G-X-G motif; other site 1166130015106 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 1166130015107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166130015108 active site 1166130015109 phosphorylation site [posttranslational modification] 1166130015110 intermolecular recognition site; other site 1166130015111 dimerization interface [polypeptide binding]; other site 1166130015112 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1166130015113 DNA binding site [nucleotide binding] 1166130015114 adenylosuccinate lyase; Provisional; Region: PRK09285 1166130015115 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1166130015116 tetramer interface [polypeptide binding]; other site 1166130015117 active site 1166130015118 putative lysogenization regulator; Reviewed; Region: PRK00218 1166130015119 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1166130015120 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 1166130015121 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 1166130015122 nudix motif; other site 1166130015123 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 1166130015124 pseudouridine synthase; Region: TIGR00093 1166130015125 probable active site [active] 1166130015126 isocitrate dehydrogenase; Validated; Region: PRK07362 1166130015127 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1166130015128 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1166130015129 active site 1166130015130 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1166130015131 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1166130015132 active site 1166130015133 ATP binding site [chemical binding]; other site 1166130015134 substrate binding site [chemical binding]; other site 1166130015135 activation loop (A-loop); other site 1166130015136 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1166130015137 Transposase; Region: HTH_Tnp_1; pfam01527 1166130015138 HTH-like domain; Region: HTH_21; pfam13276 1166130015139 Integrase core domain; Region: rve; pfam00665 1166130015140 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1166130015141 Integrase core domain; Region: rve_2; pfam13333