-- dump date   	20140619_070457
-- class       	Genbank::Feature
-- table       	feature
-- table       	main
-- field 1	id
-- field 2	type
-- field 3	name
-- field 4	contig
-- field 5	start_pos
-- field 6	end_pos
-- field 7	strand
-- field 8	description
-- field 9	chrom_position
-- field 10	organism
-- field 11	GeneID
-- header
-- id	type	name	contig	start_pos	end_pos	strand	description	chrom_position	organism	GeneID
254945000001	SEQ_END	SEQ_END	NC_005295.2	1516355	1516355	DR	NC_005295.2; contig end	1516355..1516355	Ehrlichia ruminantium str. Welgevonden	<NULL_VALUE>
YP_179868.1	CDS	gapB	NC_005295.2	89	1096	D	gapB | NAD(P)-dependent glyceraldehyde 3-phosphate dehydrogenase | len: 335 aa | Highly similar to many e.g. G3P2_BACSU O34425 Glyceraldehyde 3-phosphate dehydrogease 2 (340 aa) from Bacillus subtilis, fasta scores: E(): 2.1e-55, 44.242% identity in 330 aa overlap | Contains Pfam match to entry PF00044 gpdh, Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain and PF02800 gpdh_C, Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; glyceraldehyde 3-phosphate dehydrogenase	89..1096	Ehrlichia ruminantium str. Welgevonden	3233332
YP_179869.1	CDS	elbB	NC_005295.2	2717	3379	R	probable elbB | probable enhancing lycopene biosynthesis protein 2 | len: 220 aa | Similar to several e.g. ELBB_ECOLI P26428 Enhancing lycopene biosynthesis protein 2 (217 aa) from Escherichia coli, fasta scores: E(): 1.8e-23, 37.736% identity in 212 aa overlap | Contains Pfam match to entry PF01965 DJ-1_PfpI, DJ-1/PfpI family; isoprenoid biosynthesis protein with amidotransferase-like domain	complement(2717..3379)	Ehrlichia ruminantium str. Welgevonden	3233496
YP_179870.1	CDS	proC	NC_005295.2	3503	4318	D	proC | pyrroline-5-carboxylate reductase | len: 271 aa | Similar to many e.g. PROH_BACSU P14383 Pyrroline-5-carboxylate reductase 1 (297 aa) from Bacillus subtilis, fasta scores: E(): 7.9e-11, 30.000% identity in 210 aa overlap | Contains Pfam match to entry PF01089 P5CR, Delta 1-pyrroline-5-carboxylate reductase; pyrroline-5-carboxylate reductase	3503..4318	Ehrlichia ruminantium str. Welgevonden	3232623
YP_179871.1	CDS	dnaZ	NC_005295.2	5143	6606	D	probable dnaZ | probable DNA polymerase III, gamma subunit | len: 487 aa | Similar to the N-terminus of DP3X_ECOLI P06710 DNA polymerase III subunit tau [contains: DNA polymerase III subunit gamma] (643 aa) from Escherichia coli, fasta scores: E(): 4.2e-35, 33.604% identity in 369 aa overlap. The N-terminus of the E. coli DNA polymerase III subunit tau encodes subunit gamma | Contains PS00017 ATP/GTP-binding site motif A (P-loop) | Similar to Erum2940; DNA polymerase III gamma and tau chains	5143..6606	Ehrlichia ruminantium str. Welgevonden	3233492
YP_179872.1	CDS	Erum0050	NC_005295.2	6617	6922	D	unknown | len: 101 aa | Contains Pfam match to entry PF02575 DUF149, Uncharacterised BCR, YbaB family COG0718; hypothetical protein	6617..6922	Ehrlichia ruminantium str. Welgevonden	3232807
YP_179873.1	CDS	asd	NC_005295.2	6929	7942	D	asd | aspartate-semialdehyde dehydrogenase | len: 337 aa | Highly similar to many e.g. DHAS_BACSU Q04797 Aspartate-semialdehyde dehydrogenase (346 aa) from Bacillus subtilis, fasta scores: E(): 1.9e-35, 46.588% identity in 337 aa overlap | Contains Pfam match to entry PF01118 Semialdhyde_dh, Semialdehyde dehydrogenase, NAD binding domain and PF02774 Semialdhyde_dhC, Semialdehyde dehydrogenase, dimerisation domain | The N-terminus is almost identical to Erum8540; aspartate-semialdehyde dehydrogenase	6929..7942	Ehrlichia ruminantium str. Welgevonden	3233280
YP_179874.1	CDS	metK	NC_005295.2	9675	10880	R	methionine adenosyltransferase; catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase	complement(9675..10880)	Ehrlichia ruminantium str. Welgevonden	3233408
YP_179875.1	CDS	ubiF	NC_005295.2	11661	12833	D	probable ubiF | probable 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase | len: 390 aa | Similar to many e.g. UBIF_ECOLI P75728 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase (391 aa) from Escherichia coli, fasta scores: E(): 8e-25, 27.835% identity in 388 aa overlap | Contains Pfam match to entry PF01360 Monooxygenase, Monooxygenase | Contains PS01304 ubiH/COQ6 monooxygenase family signature | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 9-31 | C-terminus ends within a tandem repeat, 158 bp repeated 2.8 times; 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase	11661..12833	Ehrlichia ruminantium str. Welgevonden	3232620
YP_179876.1	CDS	Erum0090	NC_005295.2	13718	14299	R	probable membrane protein | len: 193 aa | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.927) with cleavage site probability 0.502 between residues 49 and 50 | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 74-96; hypothetical protein	complement(13718..14299)	Ehrlichia ruminantium str. Welgevonden	3232808
YP_179877.1	CDS	glyQ	NC_005295.2	14660	15502	D	glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha	14660..15502	Ehrlichia ruminantium str. Welgevonden	3233343
YP_179878.1	CDS	glyS	NC_005295.2	15517	17625	D	glyS | glycyl-tRNA synthetase beta chain | len: 702 aa | Similar to many e.g. SYGB_ECOLI P00961 Glycyl-tRNA synthetase beta chain (688 aa) from Escherichia coli, fasta scores: E(): 3.4e-36, 26.582% identity in 711 aa overlap | Contains Pfam match to entry PF02092 tRNA_synt_2f, Glycyl-tRNA synthetase beta subunit; glycyl-tRNA synthetase beta chain	15517..17625	Ehrlichia ruminantium str. Welgevonden	3233344
YP_179879.1	CDS	dnaJ	NC_005295.2	17690	18838	D	chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; molecular chaperone DnaJ	17690..18838	Ehrlichia ruminantium str. Welgevonden	3233309
YP_179880.1	CDS	nadC	NC_005295.2	18869	19702	R	nadC | nicotinate-nucleotide pyrophosphorylase [carboxylating] | len: 277 aa | Similar to many e.g. NADC_ECOLI P30011 Nicotinate-nucleotide pyrophosphorylase [carboxylating] (296 aa) from Escherichia coli, fasta scores: E(): 5.3e-28, 36.667% identity in 270 aa overlap | Contains Pfam match to entry PF02749 QRPTase_N, Quinolinate phosphoribosyl transferase, N-terminal domain and PF01729 QRPTase, Quinolinate phosphoribosyl transferase, C-terminal domain; nicotinate-nucleotide pyrophosphorylase	complement(18869..19702)	Ehrlichia ruminantium str. Welgevonden	3233414
YP_179881.1	CDS	Erum0150	NC_005295.2	19810	20397	D	probable integral membrane protein | len: 195 aa | Similar to many e.g. YGIH_ECOLI P31056 Hypothetical UPF0078 protein ygiH (205 aa) from Escherichia coli, fasta scores: E(): 2.1e-16, 35.938% identity in 192 aa overlap | Contains Pfam match to entry PF02660 DUF205, Domain of unknown function DUF | Contains 5 probable transmembrane helices predicted by TMHMM2.0 at aa 7-29, 52-71, 78-100, 115-134 and 147-169; hypothetical protein	19810..20397	Ehrlichia ruminantium str. Welgevonden	3232809
YP_179882.1	CDS	ruvC	NC_005295.2	20405	20887	R	ruvC | crossover junction endodeoxyribonuclease RuvC | len: 160 aa | Similar to many e.g. RUVC_ECOLI P24239 Crossover junction endodeoxyribonuclease ruvC (172 aa) from Escherichia coli, fasta scores: E(): 2.8e-11, 31.818% identity in 154 aa overlap | Contains Pfam match to entry PF02075 RuvC, Crossover junction endodeoxyribonuclease RuvC | Contains PS01321 Crossover junction endodeoxyribonuclease ruvC signature; crossover junction endodeoxyribonuclease RuvC	complement(20405..20887)	Ehrlichia ruminantium str. Welgevonden	3232719
YP_179883.1	CDS	coxC	NC_005295.2	21076	21900	R	coxC | cytochrome c oxidase subunit III | len: 274 aa | Similar to many e.g. COX3_PARDE P06030 Cytochrome c oxidase polypeptide III (273 aa) from Paracoccus denitrificans, fasta scores: E(): 5e-46, 43.478% identity in 276 aa overlap | Contains Pfam match to entry PF00510 COX3, Cytochrome c oxidase subunit III | Contains 7 probable transmembrane helices predicted by TMHMM2.0 at aa 12-34, 38-60, 81-103, 139-161, 168-190, 210-232 and 253-272; cytochrome c oxidase polypeptide III	complement(21076..21900)	Ehrlichia ruminantium str. Welgevonden	3233299
YP_179884.1	CDS	hemE	NC_005295.2	21995	23002	R	hemE | uroporphyrinogen decarboxylase | len: 335 aa | Similar to many e.g. DCUP_ECOLI P29680 Uroporphyrinogen decarboxylase (354 aa) from Escherichia coli, fasta scores: E(): 2.1e-33, 33.333% identity in 330 aa overlap | Contains Pfam match to entry PF01208 URO-D, Uroporphyrinogen decarboxylase (URO-D) | Contains PS00906 Uroporphyrinogen decarboxylase signature 1; uroporphyrinogen decarboxylase	complement(21995..23002)	Ehrlichia ruminantium str. Welgevonden	3233360
YP_179885.1	CDS	corC	NC_005295.2	23425	24291	D	possible corC | possible magnesium and cobalt efflux protein | len: 288 aa | Similar to many e.g. CORC_SALTY Q9R874 Magnesium and cobalt efflux protein (292 aa) from Salmonella typhimurium, fasta scores: E(): 2e-17, 29.766% identity in 299 aa overlap | Contains 2 Pfam matches to entry PF00571 CBS, CBS domain and PF03471 CorC_HlyC, Transporter associated domain | Similar to Erum2070; hypothetical protein	23425..24291	Ehrlichia ruminantium str. Welgevonden	3233451
YP_179886.1	CDS	Erum0200	NC_005295.2	24288	24824	R	possible protease | len: 178 aa | Similar to several bacteriophage prohead proteases e.g. VP4_BPHK7 P49860  prohead protease (GP4) (225 aa) from Bacteriophage HK97, fasta scores: E(): 3.2e-11, 38.129% identity in 139 aa overlap | Contains Pfam match to entry PF04586 Caudo_protease, Caudovirus prohead protease; hypothetical protein	complement(24288..24824)	Ehrlichia ruminantium str. Welgevonden	3232810
YP_179887.1	CDS	Erum0210	NC_005295.2	25216	26400	R	possible genetic exchange protein | len: 394 aa | Similar to several uncharacterized proteins e.g. Q9RNH1 portal protein (396 aa) from Rhodobacter capsulatus, fasta scores: E(): 3.1e-56, 42.582% identity in 364 aa overlap | Contains Pfam match to entry PF04860 Phage_portal, Phage portal protein; hypothetical protein	complement(25216..26400)	Ehrlichia ruminantium str. Welgevonden	3232811
YP_179888.1	CDS	bioC	NC_005295.2	26681	27430	D	possible bioC | possible biotin synthesis protein BioC | len: 249 aa | Similar to e.g. BIOC_ECOLI P12999 Biotin synthesis protein bioC (251 aa) from Escherichia coli, fasta scores: E(): 1.8e-06, 24.865% identity in 185 aa overlap | Similar to Erum7700; hypothetical protein	26681..27430	Ehrlichia ruminantium str. Welgevonden	3233448
YP_179889.1	CDS	nadA	NC_005295.2	27448	28392	D	3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase	27448..28392	Ehrlichia ruminantium str. Welgevonden	3233413
YP_179890.1	CDS	fdxA	NC_005295.2	28552	28929	R	fdxA | ferredoxin | len: 125 aa | Similar to many e.g. FER1_CAUCR Q45972 Ferredoxin 1 (FdI) (112 aa) from Caulobacter crescentus, fasta scores: E(): 2.7e-14, 48.760% identity in 121 aa overlap | Contains 2 Pfam matches to entry PF00037 fer4, 4Fe-4S binding domain | Contains PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature; ferredoxin	complement(28552..28929)	Ehrlichia ruminantium str. Welgevonden	3233320
YP_179891.1	CDS	Erum0250	NC_005295.2	29140	30513	D	unknown | len: 457 aa | Weakly similar to the C-terminus of Q9X4J3 120-kDa protein (688 aa) from Ehrlichia canis, fasta scores: E(): 3.4e-07, 29.341% identity in 501 aa overlap | Contains a tandem repeat, 297 bp repeated 2.8 times (or 99 bp repeated 8.4 times). Q9X4J3 from Ehrlichia canis also contains tandem repeats.; hypothetical protein	29140..30513	Ehrlichia ruminantium str. Welgevonden	3232812
YP_179892.1	CDS	virD4	NC_005295.2	31165	33570	R	virD4 | type IV secretion system protein VirD4 | len: 801 aa | Highly similar to many e.g. Q8RPL9 VirD4 (714 aa) from Ehrlichia chaffeensis, fasta scores: E(): 7.9e-197, 83.836% identity in 730 aa overlap | Contains Pfam match to entry PF02534 TRAG, TraG/TraD family | Contains 3 probable transmembrane helices predicted by TMHMM2.0 at aa 13-35, 80-102 and 161-183 | Contains a tandem repeat, 6 bp repeated 5.0 times | Similar to Erum5220; type IV secretion system component VirD4	complement(31165..33570)	Ehrlichia ruminantium str. Welgevonden	3232804
YP_179893.1	CDS	virB11	NC_005295.2	33611	34609	R	virB11 | type IV secretion system protein VirB11 | len: 332 aa | Highly similar to many e.g. Q8RPM0 VirB11 (332 aa) from Ehrlichia chaffeensis, fasta scores: E(): 1.4e-109, 90.332% identity in 331 aa overlap | Contains Pfam match to entry PF00437 GSPII_E, Type II/IV secretion system protein | Contains PS00017 ATP/GTP-binding site motif A (P-loop); type IV secretion system ATPase VirB11	complement(33611..34609)	Ehrlichia ruminantium str. Welgevonden	3232798
YP_179894.1	CDS	virB10	NC_005295.2	34633	35979	R	virB10 | type IV secretion system protein VirB10 | len: 448 aa | Similar to many e.g. Q8RPM1 VirB10 (447 aa) from Ehrlichia chaffeensis, fasta scores: E(): 8.6e-101, 71.840% identity in 451 aa overlap | Contains Pfam match to entry PF03743 TrbI, Bacterial conjugation TrbI-like protein | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 29-47 | Contains a tandem repeat, 6 bp repeated 9.0 times; VirB10 protein	complement(34633..35979)	Ehrlichia ruminantium str. Welgevonden	3232797
YP_179895.1	CDS	virB9	NC_005295.2	36000	36803	R	virB9 | type IV secretion system protein VirB9 | len: 267 aa | Highly similar to many e.g. Q8RPM2 VirB9 (273 aa) from Ehrlichia chaffeensis, fasta scores: E(): 1.5e-75, 71.898% identity in 274 aa overlap | Contains Pfam match to entry PF03524 cagX, Conjugal transfer protein | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.987 between residues 23 and 24 | Similar to Erum7530; conjugal transfer protein trbG precursor	complement(36000..36803)	Ehrlichia ruminantium str. Welgevonden	3232803
YP_179896.1	CDS	virB8	NC_005295.2	36787	37485	R	virB8 | type IV secretion system protein VirB8 | len: 232 aa | Similar to many e.g. Q8RPM3 VirB8 (237 aa) from Ehrlichia chaffeensis, fasta scores: E(): 1.4e-75, 81.197% identity in 234 aa overlap | Contains Pfam match to entry PF04335 VirB8, VirB8 protein | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 40-62; hypothetical protein	complement(36787..37485)	Ehrlichia ruminantium str. Welgevonden	3232802
YP_179897.1	CDS	Erum0310	NC_005295.2	37641	38756	R	probable riboflavin biosynthesis protein | len: 371 aa | Similar to many e.g. GCH2_AZOBR P43525 GTP cyclohydrolase II (385 aa) from Azospirillum brasilense, fasta scores: E(): 5.2e-31, 32.345% identity in 371 aa overlap and the C-terminus is similar to GCH2_ECOLI P25523 GTP cyclohydrolase II (196 aa) from Escherichia coli, fasta scores: E(): 5.9e-22, 45.122% identity in 164 aa overlap | Contains Pfam match to entry PF00925 GTP_cyclohydro2, GTP cyclohydrolase II | GTP cyclohydrolase II (ribA) is sometimes found as a bifunctional enzyme with 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP_synthase). Note that although Erum0310 is much longer than GCH2_ECOLI suggesting that it may be a bifunctional enzyme, the DHBP_synthase domain is not present.; GTP cyclohydrolase II	complement(37641..38756)	Ehrlichia ruminantium str. Welgevonden	3232813
YP_179898.1	CDS	Erum0320	NC_005295.2	40543	41607	R	unknown | len: 354 aa | Weakly similar to several e.g. Y092_RICPR Q9ZE55 Hypothetical protein RP092 (334 aa) from Rickettsia prowazekii, fasta scores: E(): 1.9e-14, 27.244% identity in 312 aa overlap | Contains Pfam match to entry PF00515 TPR, TPR Domain | Similar to Erum4110; hypothetical protein	complement(40543..41607)	Ehrlichia ruminantium str. Welgevonden	3232814
YP_179899.1	CDS	Erum0330	NC_005295.2	41683	42162	R	probable integral membrane protein | len: 159 aa | Contains 2 probable transmembrane helices predicted by TMHMM2.0 at aa 7-24 and 44-66. The initial transmembrane helix could represent a possible N-terminal signal sequence.; hypothetical protein	complement(41683..42162)	Ehrlichia ruminantium str. Welgevonden	3232815
YP_179900.1	CDS	dapF	NC_005295.2	42252	43049	R	dapF | diaminopimelate epimerase | len: 265 aa | Similar to many e.g. DAPF_ECOLI P08885 Diaminopimelate epimerase (274 aa) from Escherichia coli, fasta scores: E(): 2.3e-29, 33.824% identity in 272 aa overlap | Contains 2 Pfam matches to entry PF01678 DAP_epimerase, Diaminopimelate epimerase | Contains PS01326 Diaminopimelate epimerase signature; diaminopimelate epimerase	complement(42252..43049)	Ehrlichia ruminantium str. Welgevonden	3233305
YP_179901.1	CDS	Erum0350	NC_005295.2	43280	43711	R	unknown | len: 143 aa; hypothetical protein	complement(43280..43711)	Ehrlichia ruminantium str. Welgevonden	3232816
YP_179902.1	CDS	pgk	NC_005295.2	44788	45975	D	Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase	44788..45975	Ehrlichia ruminantium str. Welgevonden	3233441
YP_179903.1	CDS	xseA	NC_005295.2	47559	48725	R	xseA | exodeoxyribonuclease VII large subunit | len: 388 aa | Highly similar to many e.g. EX7L_ECOLI P04994 Exodeoxyribonuclease VII large subunit (456 aa) from Escherichia coli, fasta scores: E(): 9.8e-43, 40.286% identity in 350 aa overlap | Contains Pfam match to entry PF01336 tRNA_anti, OB-fold nucleic acid binding domain and PF02601 Exonuc_VII_L, Exonuclease VII, large subunit | N-terminus starts within a tandem repeat, 203 bp repeated 3.0 times | N-terminus is almost identical to Erum0371, Erum0372; exodeoxyribonuclease VII large subunit	complement(47559..48725)	Ehrlichia ruminantium str. Welgevonden	3232805
YP_179904.1	CDS	Erum0380	NC_005295.2	49128	49796	R	probable membrane protein | len: 222 aa | Almost identical to Q93FQ3 Hypothetical 6.6 kDa protein (Fragment) (58 aa) from Ehrlichia ruminantium (Gardel), fasta scores: E(): 7.1e-16, 96.552% identity in 58 aa overlap | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 88-105 | C-terminus ends within a tandem repeat, 203 bp repeated 3.0 times; hypothetical protein	complement(49128..49796)	Ehrlichia ruminantium str. Welgevonden	3232819
YP_179905.1	CDS	dapD	NC_005295.2	50073	50927	D	catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase	50073..50927	Ehrlichia ruminantium str. Welgevonden	3233304
YP_179906.1	CDS	trmE	NC_005295.2	51391	52710	D	in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE	51391..52710	Ehrlichia ruminantium str. Welgevonden	3232616
YP_179907.1	CDS	dfp	NC_005295.2	54854	55399	R	decarboxylates 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine.; phosphopantothenoylcysteine decarboxylase	complement(54854..55399)	Ehrlichia ruminantium str. Welgevonden	3233489
YP_179908.1	CDS	recG	NC_005295.2	55495	57528	D	recG | ATP-dependent DNA helicase RecG | len: 677 aa | Highly similar to many e.g. RECG_ECOLI P24230 ATP-dependent DNA helicase recG (693 aa) from Escherichia coli, fasta scores: E(): 6.5e-63, 38.066% identity in 662 aa overlap | Contains Pfam match to entry PF00270 DEAD, DEAD/DEAH box helicase and PF00271 helicase_C, Helicase conserved C-terminal domain | Contains PS00017 ATP/GTP-binding site motif A (P-loop) | Similar to Erum7290; ATP-dependent DNA helicase RecG	55495..57528	Ehrlichia ruminantium str. Welgevonden	3232648
YP_179909.1	CDS	Erum0430	NC_005295.2	59892	60854	D	possible NADH-ubiquinone oxidoreductase subunit | len: 320 aa | Similar to several uncharacterized bacterial proteins e.g. Q9A2G1 NADH-ubiquinone oxidoreductase (319 aa) from Caulobacter crescentus, fasta scores: E(): 1.5e-33, 37.778% identity in 315 aa overlap. Also similar to several eukaryotic NADH-ubiquinone oxidoreductase proteins e.g. NUEM_BOVIN P34943 NADH-ubiquinone oxidoreductase 39 kDa subunit, mitochondrial precursor (380 aa) from Bos taurus, fasta scores: E(): 3.4e-23, 31.922% identity in 307 aa overlap | Contains 2 probable transmembrane helices predicted by TMHMM2.0 at aa 169-191 and 238-260 | C-terminus ends within a tandem repeat, 283 bp repeated 3.2 times; NADH-ubiquinone oxidoreductase subunit	59892..60854	Ehrlichia ruminantium str. Welgevonden	3232820
YP_179910.1	CDS	dksA	NC_005295.2	63003	63458	R	probable dksA | probable DnaK suppressor protein | len: 151 aa | Similar to several e.g. DKSA_ECOLI P18274 DnaK suppressor protein (151 aa) from Escherichia coli, fasta scores: E(): 4.5e-08, 38.655% identity in 119 aa overlap | Contains Pfam match to entry PF01258 zf_dskA_traR, Prokaryotic dksA/traR C4-type zinc finger; DNAK suppressor protein	complement(63003..63458)	Ehrlichia ruminantium str. Welgevonden	3233490
YP_179911.1	CDS	ccmB	NC_005295.2	63571	64233	D	possible ccmB | possible heme exporter protein B | len: 220 aa | Similar to several e.g. CCMB_ECOLI P33930 Heme exporter protein B (220 aa) from Escherichia coli, fasta scores: E(): 5.9e-12, 25.688% identity in 218 aa overlap | Contains Pfam match to entry PF03379 CcmB, CcmB protein, incomplete domain | Contains 5 probable transmembrane helices predicted by TMHMM2.0 at aa 15-37, 95-117, 127-149, 156-178 and 191-213; Heme exporter protein B	63571..64233	Ehrlichia ruminantium str. Welgevonden	3233449
YP_179912.1	CDS	Erum0460	NC_005295.2	64380	65300	D	probable cation efflux system protein | len: 306 aa | Similar to many e.g. ZITB_ECOLI P75757 Zinc transporter zitB (313 aa) from Escherichia coli, fasta scores: E(): 6.7e-40, 39.858% identity in 281 aa overlap | Contains Pfam match to entry PF01545 Cation_efflux, Cation efflux family | Contains 6 probable transmembrane helices predicted by TMHMM2.0 at aa 17-36, 46-63, 83-101, 116-138, 151-173 and 177-196; zinc transporter	64380..65300	Ehrlichia ruminantium str. Welgevonden	3232821
YP_179913.1	CDS	Erum0470	NC_005295.2	65766	66392	D	probable exported protein | len: 208 aa | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.974) with cleavage site probability 0.914 between residues 23 and 24; hypothetical protein	65766..66392	Ehrlichia ruminantium str. Welgevonden	3232822
YP_179914.1	CDS	rpsT	NC_005295.2	67031	67318	R	binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20	complement(67031..67318)	Ehrlichia ruminantium str. Welgevonden	3232717
YP_179915.1	CDS	polA	NC_005295.2	69066	71663	R	has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I	complement(69066..71663)	Ehrlichia ruminantium str. Welgevonden	3233446
YP_179916.1	CDS	Erum0500	NC_005295.2	72863	73171	D	unknown | len: 102 aa; hypothetical protein	72863..73171	Ehrlichia ruminantium str. Welgevonden	3232825
YP_179917.1	CDS	argF	NC_005295.2	73502	74419	D	catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; ornithine carbamoyltransferase	73502..74419	Ehrlichia ruminantium str. Welgevonden	3233274
YP_179918.1	CDS	recF	NC_005295.2	75334	76452	D	Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F	75334..76452	Ehrlichia ruminantium str. Welgevonden	3232590
YP_179919.1	CDS	Erum0530	NC_005295.2	77021	77812	R	possible uracil DNA glycosylase | len: 263 aa | Similar to several uncharacterized proteins e.g. Q9ZCB5 Hypothetical protein RP845 (258 aa) from Rickettsia prowazekii, fasta scores: E(): 1.1e-42, 56.021% identity in 191 aa overlap | Contains Pfam match to entry PF03167 UDG, Uracil DNA glycosylase superfamily; hypothetical protein	complement(77021..77812)	Ehrlichia ruminantium str. Welgevonden	3232826
YP_179920.1	CDS	def1	NC_005295.2	77840	78385	R	probable def1 | probable peptide deformylase 1 | len: 181 aa | Similar to many e.g. DEF1_RICCN Q92IZ1 Peptide deformylase 1 (175 aa) from Rickettsia conorii, fasta scores: E(): 3.7e-24, 42.135% identity in 178 aa overlap and DEF_THETH P43522 Peptide deformylase (192 aa) from Thermus thermophilus, fasta scores: E(): 2.3e-12, 35.762% identity in 151 aa overlap | Contains Pfam match to entry PF01327 Pep_deformylase, Polypeptide deformylase | Similar to Erum1820; peptide deformylase	complement(77840..78385)	Ehrlichia ruminantium str. Welgevonden	3233487
YP_179921.1	CDS	plsC	NC_005295.2	78468	79193	D	probable plsC | probable 1-acyl-sn-glycerol-3-phosphate acyltransferase | len: 241 aa | Similar to many e.g. PLSC_ECOLI P26647 1-acyl-sn-glycerol-3-phosphate acyltransferase (245 aa) from Escherichia coli, fasta scores: E(): 4.7e-07, 25.581% identity in 215 aa overlap | Contains Pfam match to entry PF01553 Acyltransferase, Acyltransferase | Contains 3 probable transmembrane helices predicted by TMHMM2.0 at aa 4-26, 97-115 and 169-191; 1-acyl-sn-glycerol-3-phosphate acyltransferase	78468..79193	Ehrlichia ruminantium str. Welgevonden	3232578
YP_179922.1	CDS	rpe	NC_005295.2	80021	80668	D	rpe | ribulose-phosphate 3-epimerase | len: 215 aa | Similar to many e.g. RPE_ECOLI P32661 Ribulose-phosphate 3-epimerase (225 aa) from Escherichia coli, fasta scores: E(): 1.2e-28, 41.981% identity in 212 aa overlap | Contains Pfam match to entry PF00834 Ribul_P_3_epim, Ribulose-phosphate 3 epimerase family | Contains PS01085 Ribulose-phosphate 3-epimerase family signature 1 and PS01086 Ribulose-phosphate 3-epimerase family signature 2; ribulose-phosphate 3-epimerase	80021..80668	Ehrlichia ruminantium str. Welgevonden	3232660
YP_179923.1	CDS	Erum0570	NC_005295.2	82207	83004	D	probable integral membrane protein | len: 265 aa | Similar to many e.g. YRBE_ECOLI P45392 Hypothetical protein yrbE (260 aa) from Escherichia coli, fasta scores: E(): 1.1e-18, 32.227% identity in 211 aa overlap | Contains Pfam match to entry PF02405 DUF140, Domain of unknown function DUF140 | Contains 6 probable transmembrane helices predicted by TMHMM2.0 at aa 20-39, 59-81, 94-116, 152-174, 208-230 and 237-259; hypothetical protein	82207..83004	Ehrlichia ruminantium str. Welgevonden	3232827
YP_179924.1	CDS	Erum0580	NC_005295.2	83014	83733	D	probable ABC transporter, ATP binding protein | len: 239 aa | Similar to many e.g. OPCA_BACSU O34992 Glycine betaine/carnitine/choline transport ATP-binding protein (380 aa) from Bacillus subtilis, fasta scores: E(): 1.9e-21, 36.123% identity in 227 aa overlap | Contains Pfam match to entry PF00005 ABC_tran, ABC transporter | Contains PS00675 Sigma-54 interaction domain ATP-binding region A signature, PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature | Similar to Erum2550, Erum5760, Erum1190, Erum6820, Erum6270, Erum7050; ribonucleotide ABC transporter ATP-binding protein	83014..83733	Ehrlichia ruminantium str. Welgevonden	3232828
YP_179925.1	CDS	Erum0590	NC_005295.2	84258	86099	D	probable integral membrane protein | len: 613 aa | Contains 3 probable transmembrane helices predicted by TMHMM2.0 at aa 322-344, 519-541 and 551-573; hypothetical protein	84258..86099	Ehrlichia ruminantium str. Welgevonden	3232829
YP_179926.1	CDS	ispB	NC_005295.2	86701	87678	R	ispB | octaprenyl-diphosphate synthase | len: 325 aa | Similar to many e.g. ISPB_ECOLI Octaprenyl-diphosphate synthase (323 aa) from Escherichia coli, fasta scores: E(): 9.2e-39, 35.312% identity in 320 aa overlap | Contains Pfam match to entry PF00348 polyprenyl_synt, Polyprenyl synthetase | Contains PS00723 Polyprenyl synthetases signature 1 and PS00444 Polyprenyl synthetases signature 2 | Similar to Erum5660; octaprenyl-diphosphate synthase	complement(86701..87678)	Ehrlichia ruminantium str. Welgevonden	3233373
YP_179927.1	CDS	glnA	NC_005295.2	88114	89526	R	glnA | glutamine synthetase | len: 470 aa | Highly similar to many e.g. GLNA_ECOLI Glutamine synthetase (468 aa) from Escherichia coli, fasta scores: E(): 2.1e-103, 51.173% identity in 469 aa overlap | Contains Pfam match to entry PF03951 gln-synt_N, Glutamine synthetase, beta-Grasp domain and PF00120 gln-synt, Glutamine synthetase, catalytic domain | Contains PS00181 Glutamine synthetase  ATP-binding region signature and PS00182 Glutamine synthetase class-I adenylation site | Similar to Erum1480; glutamine synthetase I	complement(88114..89526)	Ehrlichia ruminantium str. Welgevonden	3233337
YP_179928.1	CDS	tyrS	NC_005295.2	89895	91151	D	tyrS | tyrosyl-tRNA synthetase | len: 418 aa | Highly similar to many e.g. SYY_ECOLI Tyrosyl-tRNA synthetase (423 aa) from Escherichia coli, fasta scores: E(): 5.4e-52, 37.831% identity in 415 aa overlap | Contains Pfam match to entry PF00579 tRNA-synt_1b, tRNA synthetases class I (W and Y) and PF01479 S4, S4 domain; tyrosyl-tRNA synthetase	89895..91151	Ehrlichia ruminantium str. Welgevonden	3232791
YP_179929.1	CDS	hemA	NC_005295.2	91191	92387	D	catalyzes the formation of 5-aminolevulinate from succinyl-CoA and glycine; 5-aminolevulinate synthase	91191..92387	Ehrlichia ruminantium str. Welgevonden	3233357
YP_179930.1	CDS	Erum0631	NC_005295.2	92734	93102	R	conserved hypothetical protein | len: 122 aa | Similar to several e.g. YH05_CLOPE Hypothetical protein CPE1705 (122 aa) from Clostridium perfringens, fasta scores: E(): 2.5e-09, 39.175% identity in 97 aa overlap | Contains Pfam match to entry PF02021 UPF0102, Uncharacterised protein family UPF0102; hypothetical protein	complement(92734..93102)	Ehrlichia ruminantium str. Welgevonden	3232830
YP_179931.1	CDS	secF	NC_005295.2	93910	94779	D	forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF	93910..94779	Ehrlichia ruminantium str. Welgevonden	3232723
YP_179932.1	CDS	fbaB	NC_005295.2	96250	97152	R	catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate; fructose-bisphosphate aldolase	complement(96250..97152)	Ehrlichia ruminantium str. Welgevonden	3233502
YP_179933.1	CDS	Erum0660	NC_005295.2	97564	108711	D	unknown | len: 3715 aa | Contains four tandem repeats, 300 bp repeated 2.6 times, 171 bp repeated 2.4 times, 471 bp repeated 2.7 times, 171 bp repeated 2.4 times; hypothetical protein	97564..108711	Ehrlichia ruminantium str. Welgevonden	3232831
YP_179934.1	CDS	pdhC	NC_005295.2	109271	110491	D	pdhC | dihydrolipoamide acetyltransferase, E2 component of pyruvate dehydrogenase complex | len: 406 aa | Similar to many e.g. ODP2_ZYMMO O66119 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex (412 aa) from Zymomonas mobilis, fasta scores: E(): 4e-70, 49.639% identity in 415 aa overlap | Contains Pfam match to entry PF00364 biotin_lipoyl, Biotin-requiring enzyme, PF02817 e3_binding, e3 binding domain and PF00198 2-oxoacid_dh 2-oxoacid dehydrogenases acyltransferase (catalytic domain) | Similar to Erum8200; branched-chain alpha-keto acid dehydrogenase subunit E2	109271..110491	Ehrlichia ruminantium str. Welgevonden	3233434
YP_179935.1	CDS	Erum0680	NC_005295.2	112630	114252	D	unknown | len: 540 aa | Similar to Erum0690; hypothetical protein	112630..114252	Ehrlichia ruminantium str. Welgevonden	3232832
YP_179936.1	CDS	Erum0690	NC_005295.2	115442	116854	D	unknown | len: 470 aa | Similar to Erum8340, Erum8170, Erum0680; hypothetical protein	115442..116854	Ehrlichia ruminantium str. Welgevonden	3232833
YP_179937.1	CDS	Erum0700	NC_005295.2	118368	120011	D	probable integral membrane protein | len: 547 aa | Contains 2 probable transmembrane helices predicted by TMHMM2.0 at aa 4-22 and 469-491 | Similar to Erum0720, Erum8170; hypothetical protein	118368..120011	Ehrlichia ruminantium str. Welgevonden	3232834
YP_179938.1	CDS	Erum0710	NC_005295.2	120001	120372	D	unknown | len: 123 aa; hypothetical protein	120001..120372	Ehrlichia ruminantium str. Welgevonden	3232835
YP_179939.1	CDS	Erum0720	NC_005295.2	120712	123507	D	unknown | len: 931 aa | Similar to Erum0700; hypothetical protein	120712..123507	Ehrlichia ruminantium str. Welgevonden	3232836
YP_179940.1	CDS	Erum0730	NC_005295.2	123762	124043	R	unknown | len: 93 aa; hypothetical protein	complement(123762..124043)	Ehrlichia ruminantium str. Welgevonden	3232837
YP_179941.1	CDS	guaA	NC_005295.2	124892	126478	D	contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase	124892..126478	Ehrlichia ruminantium str. Welgevonden	3233353
YP_179942.1	CDS	gltA	NC_005295.2	128215	129462	D	gltA | citrate synthase | len: 415 aa | Highly similar to many e.g. CISY_ECOLI P00891 Citrate synthase (427 aa) from Escherichia coli, fasta scores: E(): 2e-76, 49.517% identity in 414 aa overlap | Contains Pfam match to entry PF00285 citrate_synt, Citrate synthase | Contains PS00480 Citrate synthase signature; citrate synthase	128215..129462	Ehrlichia ruminantium str. Welgevonden	3233339
YP_179943.1	CDS	gshA	NC_005295.2	131838	133037	D	possible gshA | possible gamma-glutamylcysteine synthetase | len: 399 aa | Identical to Q93ET2 Hypothetical glutamate-cysteine ligase (fragment) (182 aa) from Ehrlichia ruminantium (Highway), fasta scores: E(): 2.2e-69, 100.000% identity in 182 aa overlap. Similar to several e.g. Q56277  gamma-glutamylcysteine synthetase (436 aa) from Thiobacillus ferrooxidans, fasta scores: E(): 1.7e-43, 35.768% identity in 397 aa overlap; hypothetical protein	131838..133037	Ehrlichia ruminantium str. Welgevonden	3233454
YP_179944.1	CDS	valS	NC_005295.2	135473	137905	D	valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase	135473..137905	Ehrlichia ruminantium str. Welgevonden	3232796
YP_179945.1	CDS	smpB	NC_005295.2	140410	140856	R	binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein	complement(140410..140856)	Ehrlichia ruminantium str. Welgevonden	3232727
YP_179946.1	CDS	ribB	NC_005295.2	140880	141515	R	ribB | 3,4-dihydroxy-2-butanone 4-phosphate synthase | len: 211 aa | Similar to many e.g. RIBB_ECOLI P24199 3,4-dihydroxy-2-butanone 4-phosphate synthase (217 aa) from Escherichia coli, fasta scores: E(): 5.1e-29, 42.640% identity in 197 aa overlap | Contains Pfam match to entry PF00926 DHBP_synthase, 3,4-dihydroxy-2-butanone 4-phosphate synthase; 3,4-dihydroxy-2-butanone 4-phosphate synthase	complement(140880..141515)	Ehrlichia ruminantium str. Welgevonden	3232651
YP_179947.1	CDS	greA	NC_005295.2	141535	142023	R	greA | transcription elongation factor GreA | len: 162 aa | Similar to many e.g. GREA_ECOLI P21346 Transcription elongation factor greA (158 aa) from Escherichia coli, fasta scores: E(): 3.8e-20, 49.057% identity in 159 aa overlap | Contains Pfam match to entry PF01272 GreA_GreB, Prokaryotic transcription elongation factor, GreA/GreB, C-terminal domain and PF03449 GreA_GreB_N, Prokaryotic transcription elongation factor, GreA/GreB, N-terminal domain | Contains PS00829 Prokaryotic transcription elongation factors signature 1; transcription elongation factor greA	complement(141535..142023)	Ehrlichia ruminantium str. Welgevonden	3233348
YP_179948.1	CDS	atpA	NC_005295.2	142068	143591	R	produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; ATP synthase F0F1 subunit alpha	complement(142068..143591)	Ehrlichia ruminantium str. Welgevonden	3233282
YP_179949.1	CDS	atpH	NC_005295.2	143594	144163	R	probable atpH | probable ATP synthase delta chain | len: 189 aa | Weakly similar to many e.g. ATPD_RHORU P05438 ATP synthase delta chain (186 aa) from Rhodospirillum rubrum, fasta scores: E(): 2.9e-07, 25.967% identity in 181 aa overlap | Contains Pfam match to entry PF00213 OSCP, ATP synthase delta (OSCP) subunit | Contains PS00389 ATP synthase delta (OSCP) subunit signature; ATP synthase subunit delta	complement(143594..144163)	Ehrlichia ruminantium str. Welgevonden	3233473
YP_179950.1	CDS	Erum0831	NC_005295.2	145084	145338	R	probable integral membrane protein | Contains 2 probable transmembrane helices predicted by TMHMM2.0 at aa 7-29 and 44-66; hypothetical protein	complement(145084..145338)	Ehrlichia ruminantium str. Welgevonden	3232841
YP_179951.1	CDS	Erum0840	NC_005295.2	145344	146585	R	probable integral membrane protein | len: 413 aa | Weakly similar to two others e.g. Q92JU0 Hypothetical transmembrane protein SMc03234 (545 aa) from Rhizobium meliloti, fasta scores: E(): 4.4e-07, 20.844% identity in 403 aa overlap | Contains 2 probable transmembrane helices predicted by TMHMM2.0 at aa 4-26 and 39-61; hypothetical protein	complement(145344..146585)	Ehrlichia ruminantium str. Welgevonden	3232842
YP_179952.1	CDS	Erum0850	NC_005295.2	146582	147358	R	probable membrane protein | len: 258 aa | Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 7-29 | Contains predicted helix-turn-helix motif; hypothetical protein	complement(146582..147358)	Ehrlichia ruminantium str. Welgevonden	3232843
YP_179953.1	CDS	lolE	NC_005295.2	147367	148602	R	probable lolE | probable lipoprotein releasing system transmembrane protein LolE | len: 411 aa | Similar to many e.g. LOLE_ECOLI P75958 Lipoprotein releasing system transmembrane protein lolE (413 aa) from Escherichia coli, fasta scores: E(): 5e-32, 30.488% identity in 410 aa overlap | Contains Pfam match to entry PF02687 FtsX, Predicted permease | Contains PS00043 Bacterial regulatory proteins, gntR family signature | Contains 4 probable transmembrane helices predicted by TMHMM2.0 at aa 21-43, 269-291, 312-334 and 372-394 | Contains predicted helix-turn-helix motif; lipoprotein releasing system transmembrane protein lolC	complement(147367..148602)	Ehrlichia ruminantium str. Welgevonden	3233522
YP_179954.1	CDS	Erum0870	NC_005295.2	150161	151180	D	conserved hypothetical protein | len: 339 aa | Similar to several from Alphaproteobacteria e.g. EAA25698 Hypothetical protein (324 aa) from Rickettsia sibirica, fasta scores: E(): 2.1e-16, 22.840% identity in 324 aa overlap. Very weakly similar to HOLA_ECOLI P28630 DNA polymerase III, delta subunit (343 aa) from Escherichia coli, fasta scores: E(): 0.13, 20.370% identity in 270 aa overlap; hypothetical protein	150161..151180	Ehrlichia ruminantium str. Welgevonden	3232844
YP_179955.1	CDS	ccmF	NC_005295.2	152474	154390	D	ccmF | cytochrome c-type biogenesis protein CcmF | len: 638 aa | Highly similar to many e.g. Cytochrome c-type biogenesis protein ccmF (647 aa) from Escherichia coli, fasta scores: E(): 1.1e-73, 37.242% identity in 631 aa overlap | Contains Pfam match to entry PF01578 CytC_asm, Cytochrome C assembly protein | Contains 14 probable transmembrane helices predicted by TMHMM2.0 at aa 5-27, 32-54, 79-101, 113-132, 163-185, 194-216, 236-253, 260-282, 302-321, 341-363, 383-405, 426-448, 479-501 and 601-623; cytochrome c-type biogenesis protein CycK	152474..154390	Ehrlichia ruminantium str. Welgevonden	3233294
YP_179956.1	CDS	Erum0890	NC_005295.2	154565	155407	D	probable aminomethyl transferase | len: 280 aa | Similar to several uncharacterized proteins e.g. Q89S51 Glycine cleavage system T protein, aminomethyltransferase (293 aa) from Bradyrhizobium japonicum, fasta scores: E(): 2.1e-17, 29.104% identity in 268 aa overlap and Q9ZD79 Hypothetical protein RP464 (285 aa) from Rickettsia prowazekii, fasta scores: E(): 9.6e-16, 26.990% identity in 289 aa overlap | Contains Pfam match to entry PF01571 GCV_T, Glycine cleavage T-protein (aminomethyl transferase) | Contains PS00436 Peroxidases active site signature; hypothetical protein	154565..155407	Ehrlichia ruminantium str. Welgevonden	3232845
YP_179957.1	CDS	purF	NC_005295.2	157638	159038	R	Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase	complement(157638..159038)	Ehrlichia ruminantium str. Welgevonden	3232633
YP_179958.1	CDS	pth	NC_005295.2	159619	160200	R	Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase	complement(159619..160200)	Ehrlichia ruminantium str. Welgevonden	3232627
YP_179959.1	CDS	rplY	NC_005295.2	160226	160852	R	the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25	complement(160226..160852)	Ehrlichia ruminantium str. Welgevonden	3232598
YP_179960.1	CDS	comF	NC_005295.2	163023	163715	R	possible comF | possible competence protein F | len: 230 aa | Similar to many e.g. COMF_HAEIN P31773 Competence protein F (229 aa) from Haemophilus influenzae, fasta scores: E(): 8.4e-13, 31.140% identity in 228 aa overlap | Contains PS00103 Purine/pyrimidine phosphoribosyl transferases signature; competence protein F (DNA transformation protein comF)	complement(163023..163715)	Ehrlichia ruminantium str. Welgevonden	3233450
YP_179961.1	CDS	dapE	NC_005295.2	163716	164867	R	dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.; succinyl-diaminopimelate desuccinylase	complement(163716..164867)	Ehrlichia ruminantium str. Welgevonden	3233485
YP_179962.1	CDS	Erum0950	NC_005295.2	166798	168507	R	probable glutathione-regulated potassium-efflux system protein | len: 569 aa | Highly similar to many e.g. KEFC_ECOLI P03819 Glutathione-regulated potassium-effllux system protein kefC (620 aa) from Escherichia coli, fasta scores: E(): 1.5e-57, 34.690% identity in 565 aa overlap | Contains Pfam match to entry PF02254 TrkA-N, TrkA-N domain and PF00999 Na_H_Exchanger, Sodium/hydrogen exchanger family | Contains 10 probable transmembrane helices predicted by TMHMM2.0 at aa 13-35, 55-77, 84-106, 116-135, 148-167, 182-204, 216-235, 294-316, 323-345 and 360-382; glutathione-regulated potassium-efflux system protein kefB	complement(166798..168507)	Ehrlichia ruminantium str. Welgevonden	3232846
YP_179963.1	CDS	Erum0960	NC_005295.2	168521	169102	R	conserved hypothetical protein | len: 193 aa | Similar to several e.g. Q82WB4 Hypothetical protein (185 aa) from Nitrosomonas europaea, fasta scores: E(): 4.9e-35, 53.514% identity in 185 aa overlap; hypothetical protein	complement(168521..169102)	Ehrlichia ruminantium str. Welgevonden	3232847
YP_179964.1	CDS	Erum0970	NC_005295.2	169193	169660	R	probable integral membrane protein | len: 155 aa | Similar to several e.g. Q92FV5  integral membrane protein (145 aa) from Rickettsia conorii, fasta scores: E(): 8e-21, 43.151% identity in 146 aa overlap | Contains Pfam match to entry PF03653 UPF0093, Uncharacterised protein family (UPF0093) | Contains 4 probable transmembrane helices predicted by TMHMM2.0 at aa 24-43, 64-86, 91-113 and 129-151; hypothetical protein	complement(169193..169660)	Ehrlichia ruminantium str. Welgevonden	3232848
YP_179965.1	CDS	pdhB	NC_005295.2	171496	172494	R	catalyzes the oxidative decarboxylation of pyruvate with concomitant acetylation of a lipoic acid-containing dihydrolipoamide acyltransferase within the complex. The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2); it contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase; pyruvate dehydrogenase subunit beta	complement(171496..172494)	Ehrlichia ruminantium str. Welgevonden	3232575
YP_179966.1	CDS	Erum0990	NC_005295.2	173802	175625	R	probable integral membrane protein | len: 607 aa | Contains 2 probable transmembrane helices predicted by TMHMM2.0 at aa 526-545 and 558-580; hypothetical protein	complement(173802..175625)	Ehrlichia ruminantium str. Welgevonden	3232849
YP_179967.1	CDS	tldD	NC_005295.2	175813	177240	D	tldD | TldD protein | len: 475 aa | Highly similar to many e.g. TLDD_ECOLI P46473 TldD protein (481 aa) from Escherichia coli, fasta scores: E(): 2e-86, 53.691% identity in 447 aa overlap | Contains Pfam match to entry PF01523 PmbA_TldD,  modulator of DNA gyrase | Similar to Erum4010; TldD protein	175813..177240	Ehrlichia ruminantium str. Welgevonden	3232742
YP_179968.1	CDS	Erum1010	NC_005295.2	177785	178876	R	translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD	complement(177785..178876)	Ehrlichia ruminantium str. Welgevonden	3232850
YP_179969.1	CDS	ispF	NC_005295.2	179823	180344	R	ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | len: 173 aa | Similar to many e.g. ISPF_ECOLI P36663 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (159 aa) from Escherichia coli, fasta scores: E(): 6.5e-23, 46.203% identity in 158 aa overlap | Contains Pfam match to entry PF02542 YgbB, YgbB family | C-terminus ends within a tandem repeat, 154 bp repeated 5.1 times; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	complement(179823..180344)	Ehrlichia ruminantium str. Welgevonden	3233374
YP_179970.1	CDS	ispD	NC_005295.2	181501	182229	R	probable ispD | probable 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase | len: 242 aa | Similar to many e.g. ISPD_ECOLI Q46893 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (235 aa) from Escherichia coli, fasta scores: E(): 5.8e-09, 26.244% identity in 221 aa overlap | Contains Pfam match to entry PF01128 IspD, Uncharacterized protein family UPF0007; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	complement(181501..182229)	Ehrlichia ruminantium str. Welgevonden	3233518
YP_179971.1	CDS	Erum1040	NC_005295.2	182499	185996	D	probable integral membrane protein | len: 1165 aa | Weakly similar to three eukaryotic proteins e.g. Q8VBY1 Phosphophoryn precursor (Dentin sialophosphoprotein) (970 aa) from Rattus norvegicus, fasta scores: E(): 9.7e-10, 22.835% identity in 762 aa overlap | Contains 2 probable transmembrane helices predicted by TMHMM2.0 at aa 35-57 and 70-92 | Contains a tandem repeat, 294 bp repeated 2.8 times | Similar to Erum5210, Erum2170; integral membrane protein	182499..185996	Ehrlichia ruminantium str. Welgevonden	3232851
YP_179972.1	CDS	Erum1050	NC_005295.2	186076	187440	D	probable integral membrane protein | len: 454 aa | Contains 2 probable transmembrane helices predicted by TMHMM2.0 at aa 39-61 and 76-98; hypothetical protein	186076..187440	Ehrlichia ruminantium str. Welgevonden	3232852
YP_179973.1	CDS	purE	NC_005295.2	188074	188586	R	purE | phosphoribosylaminoimidazole carboxylase catalytic subunit | len: 170 aa | Similar to many e.g. PUR6_ECOLI P09028 Phosphoribosylaminoimidazole carboxylase catalytic subunit (168 aa) from Escherichia coli, fasta scores: E(): 1.6e-27, 52.229% identity in 157 aa overlap | Contains Pfam match to entry PF00731 AIRC, AIR carboxylase; phosphoribosylaminoimidazole carboxylase catalytic subunit	complement(188074..188586)	Ehrlichia ruminantium str. Welgevonden	3232632
YP_179974.1	CDS	Erum1070	NC_005295.2	188576	189118	R	probable exported protein | len: 180 aa | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.864) with cleavage site probability 0.310 between residues 23 and 24; hypothetical protein	complement(188576..189118)	Ehrlichia ruminantium str. Welgevonden	3232853
YP_179975.1	CDS	ihfA	NC_005295.2	189536	189835	D	probable ihfA | probable integration host factor alpha-subunit | len: 99 aa | Similar to several e.g. IHFA_ECOLI P06984 Integration host factor alpha-subunit (99 aa) from Escherichia coli, fasta scores: E(): 8.9e-07, 35.484% identity in 93 aa overlap | Contains Pfam match to entry PF00216 Bac_DNA_binding, Bacterial DNA-binding protein | Contains PS00045 Bacterial histone-like DNA-binding proteins signature; integration host factor alpha-subunit	189536..189835	Ehrlichia ruminantium str. Welgevonden	3233515
YP_179976.1	CDS	Erum1090	NC_005295.2	189848	190216	D	conserved hypothetical protein | len: 122 aa | Similar to several uncharacterized proteins e.g. Hypothetical protein Atu1181 (203 aa) from Agrobacterium tumefaciens, fasta scores: E(): 7.8e-13, 64.384% identity in 73 aa overlap | Contains predicted helix-turn-helix motif; hypothetical protein	189848..190216	Ehrlichia ruminantium str. Welgevonden	3232854
YP_179977.1	CDS	Erum1100	NC_005295.2	191316	191801	D	unknown | len: 161 aa | Highly similar to two others Q93FQ9 Cell surface mucin-like protein (351 aa) from Ehrlichia ruminantium (Highway), fasta scores: E(): 4.7e-46, 71.429% identity in 161 aa overlap and Q93FQ8 Hypothetical 10.9 kDa protein (Fragment) (99 aa) from Ehrlichia ruminantium (Highway), fasta scores: E(): 5.1e-48, 96.970% identity in 99 aa overlap | Highly similar to the N-terminus of Erum1110; hypothetical protein	191316..191801	Ehrlichia ruminantium str. Welgevonden	3232855
YP_179978.1	CDS	Erum1110	NC_005295.2	191915	193900	D	unknown | len: 661 aa | Almost identical to Q93FQ9 Cell surface mucin-like protein (351 aa) from Ehrlichia ruminantium (Highway), fasta scores: E(): 8.1e-80, 89.349% identity in 338 aa overlap. Highly similar to Q93FQ8 Hypothetical 10.9 kDa protein (Fragment) (99 aa) from Ehrlichia ruminantium (Highway), fasta scores: E(): 1.1e-12, 67.000% identity in 100 aa overlap. Similar to many other eukaryotic proteins containing repeats. | Contains two tandem repeats, 12 bp repeated 2.5 times, 27 bp repeated 56.0 times. Q93FQ9 contains only 21.7 copies of the 27 bp repeat. | The N-terminus is highly similar to Erum1100; hypothetical protein	191915..193900	Ehrlichia ruminantium str. Welgevonden	3232856
YP_179979.1	CDS	trpS	NC_005295.2	195478	196476	R	trpS | tryptophanyl-tRNA synthetase | len: 332 aa | Identical to Q93FR0 Hypothetical tryptophanyl-tRNA ligase (259 aa) from Ehrlichia ruminantium (Highway), fasta scores: E(): 5.6e-94, 100.000% identity in 259 aa overlap. Highly similar to many e.g. SYW_ECOLI P00954 Tryptophanyl-tRNA synthetase (334 aa) from Escherichia coli, fasta scores: E(): 2.4e-45, 39.403% identity in 335 aa overlap | Contains Pfam match to entry PF00579 tRNA-synt 1b, tRNA synthetase class I (W and Y) | Contains PS00178 Aminoacyl-transfer RNA synthetase class-I signature; tryptophanyl-tRNA synthetase	complement(195478..196476)	Ehrlichia ruminantium str. Welgevonden	3232784
YP_179980.1	CDS	grpE	NC_005295.2	196670	197269	R	grpE | GrpE protein | len: 199 aa | Similar to many e.g. GRPE_CAUCR P48195 GrpE protein (HSP-70 cofactor) (198 aa) from Caulobacter crescentus, fasta scores: E(): 1.6e-11, 37.662% identity in 154 aa overlap | Contains Pfam match to entry PF01025 GrpE, GrpE | Contains PS01071 grpE protein signature; yeast GrpE protein (HSP-70 cofactor)	complement(196670..197269)	Ehrlichia ruminantium str. Welgevonden	3233351
YP_179981.1	CDS	ribD	NC_005295.2	197389	198486	D	ribD | riboflavin biosynthesis protein RibD | len: 365 aa | Similar to many e.g. RIBD_BACSU P17618 Riboflavin biosynthesis protein ribD (361 aa) from Bacillus subtilis, fasta scores: E(): 3.4e-40, 36.158% identity in 354 aa overlap | Contains Pfam match to entry PF00383 dCMP_cyt_deam, Cytidine and deoxycytidylate deaminase zinc-binding region and PF01872 RibD_C, RibD C-terminal domain | Contains PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature; riboflavin biosynthesis protein ribD	197389..198486	Ehrlichia ruminantium str. Welgevonden	3232652
YP_179982.1	CDS	Erum1150	NC_005295.2	200778	201317	D	unknown | len: 179 aa; hypothetical protein	200778..201317	Ehrlichia ruminantium str. Welgevonden	3232857
YP_179983.1	CDS	pyrG	NC_005295.2	202604	204226	R	CTP synthase; CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase	complement(202604..204226)	Ehrlichia ruminantium str. Welgevonden	3232643
YP_179984.1	CDS	secG	NC_005295.2	204233	204565	R	probable secG | probable protein-export membrane protein SecG | len: 110 aa | Weakly similar to several e.g. SECG_ECOLI P33582 Protein-export membrane protein secG (110 aa) from Escherichia coli, fasta scores: E(): 0.0065, 27.103% identity in 107 aa overlap | Contains Pfam match to entry PF03840 SecG Preprotein translocase SecG subunit | Contains 2 probable transmembrane helices predicted by TMHMM at aa 2-21 and 50-72; preprotein translocase subunit SecG	complement(204233..204565)	Ehrlichia ruminantium str. Welgevonden	3232605
YP_179985.1	CDS	Erum1180	NC_005295.2	205948	206886	D	probable integrase/recombinase XerD or XerC | len: 312 aa | Similar to many e.g. XERD_ECOLI P21891 Integrase/recombinase xerD (298 aa) from Escherichia coli, fasta scores: E(): 1.3e-14, 34.641% identity in 306 aa | Contains Pfam match to PF02899 Phage_integr_N, Phage integrase, N-terminal SAM-like domain and PF00589 Phage_integrase, Phage integrase family | Similar to Erum6590; tyrosine recombinase xerD	205948..206886	Ehrlichia ruminantium str. Welgevonden	3232858
YP_179986.1	CDS	lolD	NC_005295.2	207977	208663	R	lolD | lipoprotein releasing system ATP-binding protein LolD | len: 228 aa | Similar to many e.g. LOLD_ECOLI P75957 Lipoprotein releasing system ATP-binding protein LolD (233 aa) from Escherichia coli, fasta scores: E(): 2.7e-25, 41.629% identity in 221 aa overlap | Contains Pfam match to entry PF00005 ABC_tran, ABC transporter | Contains PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature | Similar to Erum2550, Erum5760, Erum0580, Erum6270, Erum6820, Erum2590; lipoprotein releasing system (ABC transporter) ATP-binding protein lolD	complement(207977..208663)	Ehrlichia ruminantium str. Welgevonden	3233383
YP_179987.1	CDS	maeB	NC_005295.2	209617	211884	D	NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; malic enzyme	209617..211884	Ehrlichia ruminantium str. Welgevonden	3233387
YP_179988.1	CDS	Erum1210	NC_005295.2	212100	214733	D	probable exported protein | len: 877 aa | Similar to several hypothetical proteins e.g. Q9ZDH9 Hypothetical protein RP349 (868 aa) from Rickettsia prowazekii, fasta scores: E(): 4.6e-14, 22.832% identity in 911 aa overlap | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.744) with cleavage site probability 0.436 between residues 37 and 38; hypothetical protein	212100..214733	Ehrlichia ruminantium str. Welgevonden	3232859
YP_179989.1	CDS	lnt	NC_005295.2	216108	217628	R	probable lnt | probable apolipoprotein N-acyltransferase | len: 506 aa | Similar to many e.g. LNT_SALTY O87576 Apolipoprotein N-acyltransferase (512 aa) from Salmonella typhimurium, fasta scores: E(): 2.7e-13, 26.205% identity in 477 aa overlap | Contains Pfam match to entry PF00795 CN_hydrolase, Carbon-nitrogen hydrolase | Contains 7 probable transmembrane helices predicted by TMHMM2.0 at aa 23-45, 57-79, 83-105, 118-140, 160-179, 186-203 and 478-497. The initial transmembrane helix could represent a possible signal sequence.; apolipoprotein N-acyltransferase	complement(216108..217628)	Ehrlichia ruminantium str. Welgevonden	3233521
YP_179990.1	CDS	Erum1230	NC_005295.2	218906	219466	R	unknown | len: 186 aa | Erum1230 falls almost entirely within a tandem repeat, 237 bp repeated 2.4 times; hypothetical protein	complement(218906..219466)	Ehrlichia ruminantium str. Welgevonden	3232860
YP_179991.1	CDS	Erum1240	NC_005295.2	220087	221565	D	subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone; monovalent cation/H+ antiporter subunit D	220087..221565	Ehrlichia ruminantium str. Welgevonden	3232862
YP_179992.1	CDS	Erum1250	NC_005295.2	221794	222093	R	probable membrane protein | len: 99 aa | Almost identical to Q93FQ0 Hypothetical protein (99 aa) from Ehrlichia ruminantium (Gardel), fasta scores: E(): 1.3e-37, 97.980% identity in 99 aa overlap | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 12-34; hypothetical protein	complement(221794..222093)	Ehrlichia ruminantium str. Welgevonden	3232863
YP_179993.1	CDS	Erum1260	NC_005295.2	222692	223141	R	probable membrane protein | len: 149 aa | Identical to Q93FP9 Hypothetical outer membrane protein (149 aa) from Ehrlichia ruminantium (Gardel), fasta scores: E(): 2.5e-52, 100.000% identity in 149 aa overlap. Similar to many uncharacterized proteins e.g. Q92GL7 ABC transporter substrate binding protein (149 aa) from Rickettsia conorii, fasta scores: E(): 6.9e-12, 36.301% identity in 146 aa overlap | Contains Pfam match to entry PF02470 mce, mce related protein | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 5-27. The transmembrane helix could represent a possible N-terminal signal sequence.; ABC transporter substrate-binding protein	complement(222692..223141)	Ehrlichia ruminantium str. Welgevonden	3232864
YP_179994.1	CDS	Erum1270	NC_005295.2	223169	223450	R	unknown | len: 93 aa | Similar to several bacterial hypothetical proteins e.g. Q9A739 Hypothetical protein CC1887 (105 aa) from Caulobacter crescentus, fasta scores: E(): 2.7e-08, 42.529% identity in 87 aa overlap | Contains Pfam match to entry PF05071 Complex1_17_2kD, NADH:ubiquinone oxidoreductase 17.2 kD subunit; hypothetical protein	complement(223169..223450)	Ehrlichia ruminantium str. Welgevonden	3232865
YP_179995.1	CDS	nrdR	NC_005295.2	223589	224050	D	conserved hypothetical protein | len: 153 aa | Similar to many e.g. YBAD_ECOLI P25538 Hypothetical UPF0168 protein ybaD (149 aa) from Escherichia coli, fasta scores: E(): 2.5e-20, 46.259% identity in 147 aa overlap | Contains Pfam match to entry PF03477 ATP-cone, ATP cone domain; transcriptional regulator NrdR	223589..224050	Ehrlichia ruminantium str. Welgevonden	3232866
YP_179996.1	CDS	Erum1290	NC_005295.2	225440	227134	R	unknown | len: 564 aa; hypothetical protein	complement(225440..227134)	Ehrlichia ruminantium str. Welgevonden	3232867
YP_179997.1	CDS	Erum1300	NC_005295.2	227314	231318	D	unknown | len: 1334 aa | Similar to Q9X4P9 Surface protein (956 aa) from Ehrlichia chaffeensis, fasta scores: E(): 7.8e-210, 59.425% identity in 939 aa overlap. Erum1300 contains an extra 380 aa at the N-terminus. | Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature | A small region is identical to Erum1231; hypothetical protein	227314..231318	Ehrlichia ruminantium str. Welgevonden	3232868
YP_179998.1	CDS	fbpA	NC_005295.2	232299	233345	D	probable fbpA | probable iron-binding periplasmic protein | len: 348 aa | Similar to many e.g. Q9X4Q0 Iron-binding protein (347 aa) from Ehrlichia chaffeensis, fasta scores: E(): 2.4e-99, 79.023% identity in 348 aa overlap and FBPA_HAEIN P35755 Iron-utilization periplasmic protein (332 aa) from Haemophilus influenzae, fasta scores: E(): 2.5e-17, 28.308% identity in 325 aa overlap | Contains Pfam match to entry PF01547 SBP_bac_1, Bacterial extracellular solute-binding protein | Contains PS01037 Bacterial extracellular solute-binding proteins, family 1 signature | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.746) with cleavage site probability 0.592 between residues 23 and 24; major ferric iron binding protein precursor	232299..233345	Ehrlichia ruminantium str. Welgevonden	3233503
YP_179999.1	CDS	rpsP	NC_005295.2	234110	234373	R	binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16	complement(234110..234373)	Ehrlichia ruminantium str. Welgevonden	3232713
YP_180000.1	CDS	proP	NC_005295.2	234633	235901	D	proP | proline/betaine transporter | len: 422 aa | Similar to many e.g. PROP_ECOLI P30848 Proline/betaine transporter (500 aa) from Escherichia coli, fasta scores: E(): 2.3e-43, 32.067% identity in 421 aa overlap | Contains Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter | Contains 12 probable transmembrane helices predicted by TMHMM2.0 at aa 16-38, 48-70, 77-99, 104-123, 144-166, 176-196, 231-253, 268-290, 303-320, 325-347, 368-390 and 394-411 | Similar to Erum2740, Erum2810, Erum2820; proline/betaine transporter	234633..235901	Ehrlichia ruminantium str. Welgevonden	3232624
YP_180001.1	CDS	Erum1340	NC_005295.2	236976	237143	R	conserved hypothetical protein | len: 55 aa | Similar to many e.g. YCAR_ECOLI P75844 Protein ycaR (60 aa) from Escherichia coli, fasta scores: E(): 1e-07, 50.943% identity in 53 aa overlap | Contains Pfam match to entry PF03966 DUF343, Protein of unknown function (DUF343); hypothetical protein	complement(236976..237143)	Ehrlichia ruminantium str. Welgevonden	3232869
YP_180002.1	CDS	Erum1350	NC_005295.2	237829	238524	R	probable short chain dehydrogenase | len: 231 aa | Similar to many e.g. DHG2_BACME P39483 Glucose 1-dehydrogenase II (261 aa) from Bacillus megaterium, fasta scores: E(): 1.1e-07, 27.027% identity in 222 aa overlap | Contains Pfam match to entry PF00106 adh_short, short chain dehydrogenase; pteridine reductase 1	complement(237829..238524)	Ehrlichia ruminantium str. Welgevonden	3232870
YP_180003.1	CDS	pheS	NC_005295.2	238526	239560	R	catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha	complement(238526..239560)	Ehrlichia ruminantium str. Welgevonden	3233442
YP_180004.1	CDS	rplT	NC_005295.2	239550	239921	R	binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20	complement(239550..239921)	Ehrlichia ruminantium str. Welgevonden	3232679
YP_180005.1	CDS	rpmI	NC_005295.2	239946	240146	R	rpmI | 50S ribosomal protein L35 | len: 66 aa | Similar to many e.g. RL35_BRUME Q8YE70 50S ribosomal protein L35 (66 aa) from Brucella melitensis, fasta scores: E(): 2.7e-12, 55.556% identity in 63 aa overlap | Contains Pfam match to entry PF01632 Ribosomal_L35p, Ribosomal protein L35; 50S ribosomal protein L35	complement(239946..240146)	Ehrlichia ruminantium str. Welgevonden	3232691
YP_180006.1	CDS	Erum1390	NC_005295.2	240441	241106	D	conserved hypothetical protein | len: 221 aa | Similar to several from Alphaproteobacteria e.g. Q92JG4 Hypothetical protein RC0103 (186 aa) from Rickettsia conorii, fasta scores: E(): 1.7e-36, 52.941% identity in 170 aa overlap | Contains PF06242 DUF1013, Protein of unknown function (DUF1013); hypothetical protein	240441..241106	Ehrlichia ruminantium str. Welgevonden	3232871
YP_180007.1	CDS	rho	NC_005295.2	241530	242966	D	An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho	241530..242966	Ehrlichia ruminantium str. Welgevonden	3232649
YP_180008.1	CDS	Erum1410	NC_005295.2	244325	244567	R	unknown | len: 80 aa | Similar to the C-terminus of several hypothetical proteins e.g. Q89JW2 Bll5157 protein (241 aa) from Bradyrhizobium japonicum, fasta scores: E(): 4.7e-07, 50.000% identity in 60 aa overlap | Contains Pfam match to entry PF00226 DnaJ, DnaJ domain | Almost identical to Erum7661; hypothetical protein	complement(244325..244567)	Ehrlichia ruminantium str. Welgevonden	3232872
YP_180009.1	CDS	Erum1420	NC_005295.2	244697	246106	R	probable dihydrolipoamide dehydrogenase, E3 component of pyruvate or 2-oxoglutarate dehydrogenase complex | len: 469 aa | Similar to many e.g. DLDH_ZYMMO P50970 Dihydrolipoamide dehydrogenase (466 aa) from Zymomonas mobilis, fasta scores: E(): 2.5e-79, 45.148% identity in 474 aa overlap | Contains Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase and PF02852 pyr_redox_dim, Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain | Contains PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site | Similar to Erum5130; dihydrolipoamide dehydrogenase	complement(244697..246106)	Ehrlichia ruminantium str. Welgevonden	3232873
YP_180010.1	CDS	Erum1430	NC_005295.2	246279	249134	D	unknown | len: 951 aa | Contains a tandem repeat, 198 bp repeated 2.3 times; hypothetical protein	246279..249134	Ehrlichia ruminantium str. Welgevonden	3232874
YP_180011.1	CDS	Erum1440	NC_005295.2	249295	250743	D	probable membrane protein | len: 482 aa | Similar to other rickettsial proteins e.g. Q92G01 Hypothetical protein RC1326 (523 aa) from Rickettsia conorii, fasta scores: E(): 1.8e-09, 21.063% identity in 489 aa overlap | Contains PS00148 Arginase family signature 2 | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 320-342; hypothetical protein	249295..250743	Ehrlichia ruminantium str. Welgevonden	3232875
YP_180012.1	CDS	Erum1450	NC_005295.2	250748	251374	D	probable membrane protein | len: 208 aa | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 10-32; hypothetical protein	250748..251374	Ehrlichia ruminantium str. Welgevonden	3232876
YP_180013.1	CDS	Erum1460	NC_005295.2	251361	251903	D	probable exported protein | len: 180 aa | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.966) with cleavage site probability 0.541 between residues 21 and 22; hypothetical protein	251361..251903	Ehrlichia ruminantium str. Welgevonden	3232877
YP_180014.1	CDS	Erum1470	NC_005295.2	252753	253541	D	unknown | len: 262 aa | Similar to several proteins that have been termed PhnP e.g. Q92FY5 PhnP protein (254 aa) from Rickettsia conorii, fasta scores: E(): 5.8e-27, 33.206% identity in 262 aa overlap | Contains Pfam match to entry PF00753 lactamase_B, Metallo-beta-lactamase superfamily; PhnP protein	252753..253541	Ehrlichia ruminantium str. Welgevonden	3232878
YP_180015.1	CDS	Erum1480	NC_005295.2	255354	256160	R	possible truncated glutamine synthetase | len: 268 aa | Similar to the C-terminus of many e.g. GLNA_THEMA P36205 Glutamine synthetase (439 aa) from Thermotoga maritima, fasta scores: E(): 4e-12, 29.528% identity in 254 aa overlap | Contains Pfam match to entry PF00120 gln-synt, Glutamine synthetase, catalytic domain. Note: does not contain PF03951 gln-synt_N, Glutamine synthetase, beta-Grasp domain | Similar to Erum0610; glutamine synthetase	complement(255354..256160)	Ehrlichia ruminantium str. Welgevonden	3232879
YP_180016.1	CDS	Erum1490	NC_005295.2	256166	257290	R	possible ABC transporter, membrane-spanning protein | len: 374 aa | Similar to many e.g. YQGH_BACSU P46339 Probable ABC transporter permease protein yqgH (309 aa) from Bacillus subtilis, fasta scores: E(): 4.1e-23, 29.508% identity in 305 aa overlap | Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport system inner membrane component | Contains 8 probable transmembrane helices predicted by TMHMM2.0 at aa 2-24, 47-69, 81-103, 148-170, 183-205, 225-247, 268-290 and 341-363 | Similar to Erum5280; ABC transporter permease	complement(256166..257290)	Ehrlichia ruminantium str. Welgevonden	3232880
YP_180017.1	CDS	alaS	NC_005295.2	257453	260116	D	Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase	257453..260116	Ehrlichia ruminantium str. Welgevonden	3233270
YP_180018.1	CDS	sucD	NC_005295.2	262227	263114	R	sucD | succinyl-CoA synthetase, alpha subunit | len: 295 aa | Highly similar to many e.g. SUCD_ECOLI P07459 Succinyl-CoA synthetase alpha chain (288 aa) from Escherichia coli, fasta scores: E(): 1.7e-69, 64.505% identity in 293 aa overlap | Contains Pfam match to entry PF02629 CoA_binding, CoA binding domain and PF00549 ligase-CoA, CoA-ligase | Contains PS01216 ATP-citrate lyase/succinyl-CoA ligases family signature 1 and PS00399 ATP-citrate lyase/succinyl-CoA ligases family active site; succinyl-CoA synthetase alpha chain	complement(262227..263114)	Ehrlichia ruminantium str. Welgevonden	3232733
YP_180019.1	CDS	sucC	NC_005295.2	263122	264282	R	catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta	complement(263122..264282)	Ehrlichia ruminantium str. Welgevonden	3232732
YP_180020.2	CDS	rpsU	NC_005295.2	264364	264651	R	a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21	complement(264364..264651)	Ehrlichia ruminantium str. Welgevonden	3233464
YP_180021.1	CDS	Erum1540	NC_005295.2	264780	265808	R	probable exported protein | len: 342 aa | Almost identical to Q46326 (Clone pF5.2) immunodominant protein (277 aa) from Ehrlichia ruminantium (Crystal Springs), fasta scores: E(): 3e-104, 99.278% identity in 277 aa overlap. Similar to several uncharacterized proteins e.g. Q92SA4  phosphate-binding periplasmic protein (344 aa) from Rhizobium meliloti, fasta scores: E(): 4.5e-38, 36.508% identity in 315 aa overlap | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.969) with cleavage site probability 0.349 between residues 20 and 21; protein sphX precursor	complement(264780..265808)	Ehrlichia ruminantium str. Welgevonden	3232881
YP_180022.1	CDS	map2	NC_005295.2	265877	266506	R	map2 | major antigenic protein 2 | len: 209 aa | Identical to Q9R416 Major antigenic protein 2 (209 aa) from Ehrlichia ruminantium (Um Banein and Palm River), fasta scores: E(): 6.4e-76, 100.000% identity in 209 aa overlap. Similar to P70747 Major surface protein 5 (210 aa) from Anaplasma marginale, fasta scores: E(): 1.8e-35, 49.275% identity in 207 aa overlap | Contains Pfam match to entry PF02630 SCO1-SenC, SCO1/SenC | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 7-29. The transmembrane helix could represent a possible N-terminal signal sequence.; SCO2 like-protein	complement(265877..266506)	Ehrlichia ruminantium str. Welgevonden	3233405
YP_180023.1	CDS	Erum1560	NC_005295.2	267641	268678	R	probable 2-nitropropane dioxygenase | len: 345 aa | Similar to many uncharacterized proteins e.g. Q8RGV3 Enoyl-[acyl-carrier-protein] reductase (318 aa) from Fusobacterium nucleatum, fasta scores: E(): 9.4e-31, 38.679% identity in 318 aa overlap | Contains Pfam match to entry PF03060 NPD, 2-nitropropane dioxygenase; hypothetical protein	complement(267641..268678)	Ehrlichia ruminantium str. Welgevonden	3232882
YP_180024.1	CDS	Erum1570	NC_005295.2	268691	269212	R	probable cytochrome b561 | len: 173 aa | Similar to many e.g. C56I_ECOLI P75925 Cytochrome b561 homolog 2 (188 aa) from Escherichia coli, fasta scores: E(): 1.4e-10, 29.651% identity in 172 aa overlap | Contains Pfam match to entry PF01292 Ni_hydr_CYTB, Cytochrome b561 family | Contains 5 probable transmembrane helices predicted by TMHMM2.0 at aa 7-29, 44-63, 76-98, 103-125 and 138-157. The initial transmembrane helix could represent a possible N-terminal signal peptide.; cytochrome b561	complement(268691..269212)	Ehrlichia ruminantium str. Welgevonden	3232883
YP_180025.1	CDS	Erum1580	NC_005295.2	270191	271801	D	probable ABC transporter, membrane-spanning protein | len: 536 aa | Similar to many e.g. FBB2_HAEIN P71338 Iron(III)-transport system permease protein FbpB 2 (506 aa) from Haemophilus influenzae, fasta scores: E(): 2.2e-20, 26.376% identity in 527 aa overlap | Contains 2 Pfam matches to entry PF00528 BPD_transp, Binding-protein-dependent transport system inner membrane component | Contains 12 probable transmembrane helices predicted by TMHMM2.0 at aa 9-31, 51-73, 86-108, 128-150, 179-201, 233-252, 282-304, 330-352, 364-386, 390-409, 456-478 and 502-524; Iron(III)-transport system permease protein fbpB 2	270191..271801	Ehrlichia ruminantium str. Welgevonden	3232884
YP_180026.1	CDS	Erum1590	NC_005295.2	272708	274252	R	probable secretion protein | len: 514 aa | Similar to many e.g. APRE_PSEAE Q03025 Alkaline protease secretion protein (432 aa) from Pseudomonas aeruginosa, fasta scores: E(): 2.4e-23, 30.607% identity in 428 aa overlap | Contains Pfam match to entry PF00529 HlyD, HlyD family secretion protein | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 76-98; alkaline protease secretion protein AprE	complement(272708..274252)	Ehrlichia ruminantium str. Welgevonden	3232885
YP_180027.1	CDS	Erum1600	NC_005295.2	274516	275130	R	unknown | len: 204 aa | Weakly similar to several hypothetical proteins e.g. Q9ZCU5 Hypothetical protein RP616 (203 aa) from Rickettsia prowazekii, fasta scores: E(): 6.3e-09, 28.000% identity in 175 aa overlap; hypothetical protein	complement(274516..275130)	Ehrlichia ruminantium str. Welgevonden	3232886
YP_180028.1	CDS	Erum1610	NC_005295.2	275984	277612	R	conserved hypothetical protein | len: 542 aa | Similar to many e.g. Y551_SYNY3 P54123 Hypothetical protein slr0551 (640 aa) from Synechocystis sp., fasta scores: E(): 9.6e-59, 31.957% identity in 557 aa overlap | Contains Pfam match to entry PF00753 lactamase_B, Metallo-beta-lactamase superfamily; hypothetical protein	complement(275984..277612)	Ehrlichia ruminantium str. Welgevonden	3232887
YP_180029.1	CDS	Erum1620	NC_005295.2	277939	278532	D	probable integral membrane protein | len: 197 aa | Contains 4 probable transmembrane helices predicted by TMHMM2.0 at aa 12-31, 41-63, 102-124 and 134-156; hypothetical protein	277939..278532	Ehrlichia ruminantium str. Welgevonden	3232888
YP_180030.1	CDS	rpsL	NC_005295.2	280109	280480	D	interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12	280109..280480	Ehrlichia ruminantium str. Welgevonden	3232709
YP_180031.1	CDS	rpsG	NC_005295.2	280497	280979	D	binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7	280497..280979	Ehrlichia ruminantium str. Welgevonden	3232704
YP_180032.1	CDS	fusA	NC_005295.2	281003	283072	D	EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G	281003..283072	Ehrlichia ruminantium str. Welgevonden	3233331
YP_180033.1	CDS	tufA	NC_005295.2	283090	284277	D	EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu	283090..284277	Ehrlichia ruminantium str. Welgevonden	3232789
YP_180034.1	CDS	nusG	NC_005295.2	284600	285139	D	nusG | transcription antitermination protein NusG | len: 179 aa | Similar to many e.g. NUSG_ECOLI P16921 Transcription antitermination protein NusG (180 aa) from Escherichia coli, fasta scores: E(): 6.4e-18, 37.500% identity in 176 aa overlap | Contains Pfam match to entry PF02357 NusG, Transcription termination factor nusG and PF00467 KOW, KOW motif; transcription antitermination protein NUSG	284600..285139	Ehrlichia ruminantium str. Welgevonden	3233429
YP_180035.1	CDS	rplK	NC_005295.2	285143	285586	D	binds directly to 23S ribosomal RNA; 50S ribosomal protein L11	285143..285586	Ehrlichia ruminantium str. Welgevonden	3232670
YP_180036.1	CDS	rplA	NC_005295.2	285604	286266	D	in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1	285604..286266	Ehrlichia ruminantium str. Welgevonden	3232662
YP_180037.1	CDS	rplJ	NC_005295.2	286284	286766	D	binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10	286284..286766	Ehrlichia ruminantium str. Welgevonden	3232669
YP_180038.1	CDS	rplL	NC_005295.2	286802	287197	D	present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12	286802..287197	Ehrlichia ruminantium str. Welgevonden	3232671
YP_180039.1	CDS	rpoB	NC_005295.2	287245	291387	D	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta	287245..291387	Ehrlichia ruminantium str. Welgevonden	3232694
YP_180040.1	CDS	rpoC	NC_005295.2	291407	295642	D	rpoC | DNA-directed RNA polymerase beta' chain | len: 1411 aa | Highly similar to many e.g. RPOC_ECOLI P00577 DNA-directed RNA polymerase beta' chain (1407 aa) from Escherichia coli, fasta scores: E(): 0, 55.305% identity in 1376 aa overlap | Contains Pfam match to entry PF04997 RNA_pol_Rpb1_1, RNA polymerase Rpb1, domain 1, PF00623 RNA_pol_Rpb1_2, RNA polymerase Rpb1, domain 2, PF04983 RNA_pol_Rpb1_3, RNA polymerase Rpb1, domain 3, PF05000 RNA_pol_Rpb1_4, RNA polymerase Rpb1, domain 4 and PF04998 RNA_pol_Rpb1_5, RNA polymerase Rpb1, domain 5; DNA-directed RNA polymerase beta' chain	291407..295642	Ehrlichia ruminantium str. Welgevonden	3232695
YP_180041.1	CDS	bioF	NC_005295.2	296873	297976	D	probable bioF | probable 8-amino-7-oxononanoate synthase | len: 367 aa | Similar to many e.g. BIOF_ECOLI P12998 8-amino-7-oxononanoate synthase (384 aa) from Escherichia coli, fasta scores: E(): 2.1e-23, 31.165% identity in 369 aa overlap | Contains Pfam match to entry PF00155 aminotran_1_2, Aminotransferase class I and II | Contains PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site | Similar to Erum0630; 8-amino-7-oxononanoate synthase	296873..297976	Ehrlichia ruminantium str. Welgevonden	3233476
YP_180042.1	CDS	Erum1750	NC_005295.2	298429	298857	D	probable integral membrane protein | len: 142 aa | Similar to several e.g. Q92I13 Hypothetical protein RC0607 (144 aa) from Rickettsia conorii, fasta scores: E(): 2.6e-10, 30.769% identity in 143 aa overlap | Contains 4 probable transmembrane helices predicted by TMHMM2.0 at aa 9-31, 41-63, 87-109 and 119-141 | Contains PS00225 Crystallins beta and gamma 'Greek key' motif signature; hypothetical protein	298429..298857	Ehrlichia ruminantium str. Welgevonden	3232889
YP_180043.1	CDS	rnhB	NC_005295.2	300081	300719	R	RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII	complement(300081..300719)	Ehrlichia ruminantium str. Welgevonden	3232658
YP_180044.1	CDS	Erum1770	NC_005295.2	301824	306413	D	unknown | len: 1529 aa; hypothetical protein	301824..306413	Ehrlichia ruminantium str. Welgevonden	3232890
YP_180045.1	CDS	Erum1780	NC_005295.2	306800	307318	R	possible Na+/H+ antiporter subunit | len: 172 aa | Weakly similar to Q8U1Q2  multisubunit Na+/H+ antiporter (201 aa) from Pyrococcus furiosus, fasta scores: E(): 4e-05, 28.378% identity in 148 aa overlap | Contains Pfam match to entry PF01899 MNHE, Na+/H+ ion antiporter subunit | Contains 2 probable transmembrane helices predicted by TMHMM2.0 at aa 7-36 and 63-85; hypothetical protein	complement(306800..307318)	Ehrlichia ruminantium str. Welgevonden	3232891
YP_180046.1	CDS	Erum1790	NC_005295.2	307463	308080	D	probable membrane protein | len: 205 aa | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 4-26; hypothetical protein	307463..308080	Ehrlichia ruminantium str. Welgevonden	3232892
YP_180047.1	CDS	Erum1800	NC_005295.2	308694	309467	R	type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP; pantothenate kinase	complement(308694..309467)	Ehrlichia ruminantium str. Welgevonden	3232893
YP_180048.1	CDS	pyrD	NC_005295.2	309479	310519	R	catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2	complement(309479..310519)	Ehrlichia ruminantium str. Welgevonden	3232641
YP_180049.1	CDS	def2	NC_005295.2	310695	311279	D	probable def2 | probable peptide deformylase 2 | len: 194 aa | Similar to several e.g. DEF_THETH P43522 Peptide deformylase (192 aa) from Thermus thermophilus, fasta scores: E(): 9e-07, 28.276% identity in 145 aa overlap | Contains Pfam match to entry PF01327 Pep_deformylase, Polypeptide deformylase | Similar to Erum0540; peptide deformylase	310695..311279	Ehrlichia ruminantium str. Welgevonden	3233488
YP_180050.1	CDS	argH	NC_005295.2	312965	314353	R	catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase	complement(312965..314353)	Ehrlichia ruminantium str. Welgevonden	3233276
YP_180051.1	CDS	Erum1840	NC_005295.2	315725	316528	D	unknown | len: 267 aa | Weakly similar to several patatin-like proteins from plants e.g. Q8LBT5 Patatin-like protein (383 aa) from Arabidopsis thaliana, fasta scores: E(): 8e-10, 24.407% identity in 295 aa overlap | Contains Pfam match to entry PF01734 Patatin, Patatin-like phospholipase; hypothetical protein	315725..316528	Ehrlichia ruminantium str. Welgevonden	3232894
YP_180052.1	CDS	pdxH	NC_005295.2	316721	317305	D	pdxH | pyridoxamine 5'-phosphatate oxidase | len: 194 aa | Similar to many e.g. PDXH_ECOLI P28225 Pyridoxamine 5'-phosphate oxidase (217 aa) from Escherichia coli, fasta scores: E(): 4.9e-25, 40.526% identity in 190 aa overlap | Contains Pfam match to entry PF01243 Pyridox_oxidase, Pyridoxamine 5'-phosphate oxidase; pyridoxamine 5'-phosphate oxidase	316721..317305	Ehrlichia ruminantium str. Welgevonden	3233435
YP_180053.1	CDS	Erum1851	NC_005295.2	318172	318450	R	unknown | len: 92 aa | Weakly similar to several e.g. Y457_BUCAP Hypothetical protein BUsg457 (111 aa) from Buchnera aphidicola, fasta scores: E(): 5.1e-06, 36.782% identity in 87 aa overlap; hypothetical protein	complement(318172..318450)	Ehrlichia ruminantium str. Welgevonden	3232895
YP_180054.1	CDS	Erum1860	NC_005295.2	318709	319521	D	probable membrane protein | len: 270 aa | Similar to Q8YUM6 Hypothetical protein All2314 (281 aa) from Anabaena sp., fasta scores: E(): 7.8e-15, 28.090% identity in 267 aa overlap | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 7-24. The transmembrane helix could represent a possible signal sequence.; hypothetical protein	318709..319521	Ehrlichia ruminantium str. Welgevonden	3232896
YP_180055.1	CDS	dnaE	NC_005295.2	321503	324862	D	dnaE | DNA polymerase III, alpha subunit | len: 1119 aa | Highly similar to many e.g. DP3A_ECOLI P10443 DNA polymerase III alpha subunit (1160 aa) from Escherichia coli, fasta scores: E(): 4e-99, 38.367% identity in 1139 aa overlap | Contains Pfam match to entry PF02231 PHP_N, PHP domain N-terminal region and PF02811 PHP_C, PHP domain C-terminal region; DNA polymerase III alpha subunit	321503..324862	Ehrlichia ruminantium str. Welgevonden	3233308
YP_180056.1	CDS	aroE	NC_005295.2	325419	326702	D	aroE | 3-phosphoshikimate 1-carboxyvinyltransferase | len: 427 aa | Similar to many e.g. AROA_BACSU P20691 3-phosphoshikimate 1-carboxyvinyltransferase (428 aa) from Bacillus subtilis, fasta scores: E(): 1e-19, 26.406% identity in 409 aa overlap | Contains Pfam match to entry PF00275 EPSP_synthase, EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); 3-phosphoshikimate 1-carboxyvinyltransferase	325419..326702	Ehrlichia ruminantium str. Welgevonden	3233279
YP_180057.1	CDS	sdhC	NC_005295.2	328606	329004	D	probable sdhC | probable succinate dehydrogenase cytochrome b-556 subunit | len: 132 aa | Similar to many e.g. DHSC_ECOLI P10446 Succinate dehydrogenase cytochrome b-556 subunit (129 aa) from Escherichia coli, fasta scores: E(): 2.5e-08, 31.538% identity in 130 aa overlap | Contains Pfam match to entry PF01127 Sdh_cyt, Succinate dehydrogenase cytochrome b subunit | Contains PS01000 Succinate dehydrogenase cytochrome b subunit signature 1 and PS01001 Succinate dehydrogenase cytochrome b subunit signature 2 | Contains 3 probable transmembrane helices predicted by TMHMM2.0 at aa 28-50, 65-87 and 108-130; succinate dehydrogenase cytochrome B-556 subunit	328606..329004	Ehrlichia ruminantium str. Welgevonden	3232601
YP_180058.1	CDS	sdhD	NC_005295.2	329014	329364	D	probable sdhD | probable succinate dehydrogenase cytochrome b small subunit | len: 116 aa | Weakly similar to several e.g. O82997 Succinate dehydrogenase cytochrome b small subunit (127 aa) from Rhodospirillum rubrum, fasta scores: E(): 5.2e-05, 31.356% identity in 118 aa overlap | Contains Pfam match to entry PF001127 Sdh_cyt, Succinate dehydrogenase cytochrome b subunit | Contains 3 probable transmembrane helices predicted by TMHMM2.0 at aa 13-35, 55-77 and 90-112; succinate dehydrogenase hydrophobic membrane anchor protein	329014..329364	Ehrlichia ruminantium str. Welgevonden	3232602
YP_180059.1	CDS	Erum1900	NC_005295.2	329566	330819	D	unknown | len: 417 aa; hypothetical protein	329566..330819	Ehrlichia ruminantium str. Welgevonden	3232897
YP_180060.1	CDS	thiD	NC_005295.2	331070	331870	R	probable thiD | probable phosphomethylpyrimidine kinase | len: 266 aa | Similar to many e.g. THID_ECOLI P76422 Phosphomethylpyrimidine kinase (266 aa) from Escherichia coli, fasta scores: E(): 1.4e-26, 38.911% identity in 257 aa overlap; phosphomethylpyrimidine kinase	complement(331070..331870)	Ehrlichia ruminantium str. Welgevonden	3232609
YP_180061.1	CDS	Erum1920	NC_005295.2	331827	332519	R	conserved hypothetical protein | len: 230 aa | Similar to several mostly from other Alphaproteobacteria e.g. Q9ZCT2 Hypothetical protein RP631 (221 aa) from Rickettsia prowazekii, fasta scores: E(): 7.5e-16, 32.432% identity in 222 aa overlap | Contains PS00017 ATP/GTP-binding site motif A (P-loop); hypothetical protein	complement(331827..332519)	Ehrlichia ruminantium str. Welgevonden	3232898
YP_180062.1	CDS	Erum1930	NC_005295.2	333154	334275	R	probable integral membrane protein | len: 373 aa | Similar to many e.g. PERM_ECOLI P77406  permease perM (353 aa) from Escherichia coli, fasta scores: E(): 2.4e-10, 23.496% identity in 349 aa overlap | Contains Pfam match to entry PF01594 UPF0118, Domain of unknown function DUF20 | Contains 8 probable transmembrane helices predicted by TMHMM2.0 at aa 9-28, 32-51, 64-86, 169-191, 237-259, 264-286, 293-315 and 325-356; hypothetical protein	complement(333154..334275)	Ehrlichia ruminantium str. Welgevonden	3232899
YP_180063.1	CDS	rpsD	NC_005295.2	334645	335253	R	primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4	complement(334645..335253)	Ehrlichia ruminantium str. Welgevonden	3232701
YP_180064.1	CDS	Erum1950	NC_005295.2	337941	338150	D	conserved hypothetical protein | len: 69 aa | Similar to several e.g. YFHJ_ECOLI P37096 Hypothetical protein yfhJ (66 aa) from Escherichia coli, fasta scores: E(): 3e-07, 46.774% identity in 62 aa overlap | Contains Pfam match to entry PF04384 DUF528, Protein of unknown function (DUF528); hypothetical protein	337941..338150	Ehrlichia ruminantium str. Welgevonden	3232900
YP_180065.1	CDS	Erum1960	NC_005295.2	338225	339376	R	probable exported protein | len: 383 aa | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.800) with cleavage site probability 0.406 between residues 24 and 25; hypothetical protein	complement(338225..339376)	Ehrlichia ruminantium str. Welgevonden	3232901
YP_180066.1	CDS	Erum1970	NC_005295.2	339411	340199	R	possible acetyltransferase | len: 262 aa | Contains Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family; hypothetical protein	complement(339411..340199)	Ehrlichia ruminantium str. Welgevonden	3232902
YP_180067.1	CDS	pgpA	NC_005295.2	340200	340706	R	probable pgpA | probable phosphatidylglycerophosphatase A | len: 168 aa | Similar to several uncharacterized proteins e.g. Q92GG2 Phosphatidylglycerophosphatase A (199 aa) from Rickettsia conorii, fasta scores: E(): 1.8e-10, 36.410% identity in 195 aa overlap | Contains Pfam match to entry PF04608 PgpA, Phosphatidylglycerophosphatase A | Contains 4 probable transmembrane helices predicted by TMHMM2.0 at aa 36-58, 73-95, 102-124 and 144-166; phosphatidylglycerophosphatase A	complement(340200..340706)	Ehrlichia ruminantium str. Welgevonden	3232576
YP_180068.1	CDS	tig	NC_005295.2	341671	343011	D	tig | trigger factor | len: 446 aa | Similar to many e.g. TIG_ECOLI P22257 Trigger factor (TF) (432 aa) from Escherichia coli, fasta scores: E(): 7.5e-12, 23.678% identity in 435 aa overlap | Contains Pfam match to entry PF05697 Trigger_N, Bacterial trigger factor protein (TF), PF00254 FKBP, FKBP-type peptidyl-prolyl cis-trans isomerase and PF05698 Trigger_C, Bacterial trigger factor protein (TF) C-terminus; trigger factor	341671..343011	Ehrlichia ruminantium str. Welgevonden	3232740
YP_180069.1	CDS	clpP	NC_005295.2	343074	343670	D	hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit	343074..343670	Ehrlichia ruminantium str. Welgevonden	3233297
YP_180070.1	CDS	clpX	NC_005295.2	343690	344910	D	binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX	343690..344910	Ehrlichia ruminantium str. Welgevonden	3233298
YP_180071.1	CDS	lon	NC_005295.2	344920	347325	D	lon | ATP-dependent protease La | len: 801 aa | Highly similar to many e.g. LON_ECOLI P08177 ATP-dependent protease La (784 aa) from Escherichia coli, fasta scores: E(): 4.6e-132, 52.412% identity in 767 aa overlap | Contains Pfam match to entry PF02190 LON, ATP-dependent protease La (LON) domain, PF00004 AAA, ATPase family associated with various cellular activities (AAA) and PF05362 Lon_C, Lon protease (S16) C-terminal proteolytic domain | Contains PS00017 ATP/GTP-binding site motif A (P-loop) and PS01046 ATP-dependent serine proteases, lon family, serine active site; ATP-dependent protease La	344920..347325	Ehrlichia ruminantium str. Welgevonden	3233384
YP_180072.1	CDS	fmt	NC_005295.2	349866	350777	D	fmt | methionyl-tRNA formyltransferase | len: 303 aa | Similar to many e.g. FMT_ECOLI P23882 Methionyl-tRNA formyltransferase (314 aa) from Escherichia coli, fasta scores: E(): 7.2e-37, 41.196% identity in 301 aa overlap | Contains Pfam match to entry PF00551 formyl_transf, Formyl transferase and PF02911 formyl_trans_C, Formyl transferase, C-terminal domain | Similar to Erum6370; methionyl-tRNA formyltransferase	349866..350777	Ehrlichia ruminantium str. Welgevonden	3233323
YP_180073.1	CDS	Erum2040	NC_005295.2	351158	351976	D	conserved hypothetical protein | len: 272 aa | Similar to many e.g. Y8J1_AGRT5 Q8U7F8 Hypothetical UPF0176 protein Atu4491 (314 aa) from Agrobacterium tumefaciens, fasta scores: E(): 2.4e-43, 43.273% identity in 275 aa overlap | Contains Pfam match to entry PF00581 Rhodanese, Rhodanese-like domain; hypothetical protein	351158..351976	Ehrlichia ruminantium str. Welgevonden	3232903
YP_180074.1	CDS	Erum2050	NC_005295.2	352405	353262	D	conserved hypothetical protein | len: 285 aa | Similar to many e.g. YDIA_ECOLI P03822 Hypothetical UPF0085 protein ydiA (277 aa) from Escherichia coli, fasta scores: E(): 3.2e-17, 31.673% identity in 281 aa overlap | Contains Pfam match to entry PF03618 DUF299, Domain of unknown function (DUF299); hypothetical protein	352405..353262	Ehrlichia ruminantium str. Welgevonden	3232904
YP_180075.1	CDS	thiE	NC_005295.2	353645	354697	D	probable thiE | probable thiamine-phosphate pyrophosphorylase | len: 350 aa | Similar to many e.g. THIE_ECOLI P30137 Thiamine-phosphate pyrophosphorylase (211 aa) from Escherichia coli, fasta scores: E(): 3.6e-27, 46.316% identity in 190 aa overlap. Note that Erum2060 contains an extra 140 aa at the N-terminus | Contains Pfam match to entry PF02581 TMP-TENI, Thiamine monophosphate synthase/TENI; thiamine-phosphate pyrophosphorylase	353645..354697	Ehrlichia ruminantium str. Welgevonden	3232610
YP_180076.1	CDS	Erum2070	NC_005295.2	355581	356876	R	probable integral membrane protein | len: 431 aa | Similar to many e.g. FJD_ECOLI P37908 Hypothetical protein yfjD (428 aa) from Escherichia coli, fasta scores: E(): 3.5e-42, 31.340% identity in 418 aa overlap | Contains Pfam match to entry PF01595 DUF21, Domain of unknown function DUF21, 2 Pfam matches to entry PF00571 CBS, CBS domain and PF03471 CorC_HlyC, Transporter associated domain | Contains 4 probable transmembrane helices predicted by TMHMM2.0 at aa 4-23, 61-83, 93-112 and 125-147. The initial transmembrane helix could represent a possible N-terminal signal sequence. | Similar to Erum0190; hypothetical protein	complement(355581..356876)	Ehrlichia ruminantium str. Welgevonden	3232905
YP_180077.1	CDS	Erum2080	NC_005295.2	357016	357300	D	probable integral membrane protein | len: 94 aa | Similar to several e.g. YR5A_AGRT5 Q8U530 Hypothetical protein Atu2659.1/AGR_C_4820 (106 aa) from Agrobacterium tumefaciens, fasta scores: E(): 1e-06, 34.884% identity in 86 aa overlap | Contains Pfam match to entry PF02325 YGGT, YGGT family | Contains 2 probable transmembrane helices predicted by TMHMM2.0 at aa 12-34 and 62-84; hypothetical protein	357016..357300	Ehrlichia ruminantium str. Welgevonden	3232906
YP_180078.1	CDS	ftsK	NC_005295.2	357313	359880	D	probable ftsK | probable cell division protein FtsK | len: 855 aa | Similar in length to several uncharacterized proteins that have been termed FtsK e.g. Q92L89  cell division transmembrane protein FtsK (881 aa) from Rhizobium meliloti, fasta scores: E(): 6.6e-111, 43.955% identity in 885 aa overlap. C terminus is highly similar to many e.g. FTSK_ECOLI P46889 Cell division protein ftsK (1329 aa) from Escherichia coli, fasta scores: E(): 8e-80, 51.205% identity in 498 aa overlap | Contains Pfam match to entry PF01580 FtsK_SpoIIIE, FtsK/SpoIIIE family | Contains PS00017 ATP/GTP-binding site motif A (P-loop) | Contains 5 probable transmembrane helices predicted by TMHMM2.0 at aa 9-31, 60-82, 89-108, 123-145 and 150-167. The initial transmembrane helix could represent a possible N-terminal signal sequence. | Contains a tandem repeat, 45 bp repeated 4.1 times (or 15 bp repeated 11.6 times, or 30 bp repeated 4.4 times); DNA translocase FtsK	357313..359880	Ehrlichia ruminantium str. Welgevonden	3233508
YP_180079.1	CDS	Erum2100	NC_005295.2	360550	361473	R	probable integral membrane protein | len: 307 aa | Contains 6 probable transmembrane helices predicted by TMHMM2.0 at aa 46-68, 83-105, 137-159, 169-188, 209-231 and 246-268; hypothetical protein	complement(360550..361473)	Ehrlichia ruminantium str. Welgevonden	3232907
YP_180080.1	CDS	argD	NC_005295.2	361556	362731	R	DapATase; functions in arginine biosynthetic pathway; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine; acetylornithine transaminase protein	complement(361556..362731)	Ehrlichia ruminantium str. Welgevonden	3233273
YP_180081.1	CDS	Erum2120	NC_005295.2	362872	364305	D	possible histidine kinase sensor component of a two-component regulatory system | len: 477 aa | Similar to many e.g. Q9ZDU5 Histidine kinase sensor protein (BARA) (497 aa) from Rickettsia prowazekii, fasta scores: E(): 7.4e-45, 45.482% identity in 332 aa overlap | Contains Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase and PF00512 HisKA, His Kinase A (phosphoacceptor) domain | Contains 2 probable transmembrane helices predicted by TMHMM2.0 at aa 12-34 and 190-212. The initial transmembrane helix could represent a possible N-terminal signal sequence. | Note that the regulator component is absent/unattached.; sensor protein	362872..364305	Ehrlichia ruminantium str. Welgevonden	3232908
YP_180082.1	CDS	mutL	NC_005295.2	365216	367285	D	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein	365216..367285	Ehrlichia ruminantium str. Welgevonden	3233410
YP_180083.1	CDS	smf	NC_005295.2	368495	369622	R	probable smf | probable DNA processing protein chain A | len: 375 aa | Similar to many e.g. SMF_HAEIN P43862 Smf protein (DNA processing chain A) (373 aa) from Haemophilus influenzae, fasta scores: E(): 1.5e-31, 38.832% identity in 291 aa overlap | Contains Pfam match to entry PF02481 SMF, SMF family; Smf protein (DNA processing chain A)	complement(368495..369622)	Ehrlichia ruminantium str. Welgevonden	3232606
YP_180084.1	CDS	fabF	NC_005295.2	369755	371026	R	fabF | 3-oxoacyl-[acyl-carrier-protein] synthase II | len: 423 aa | Highly similar to many e.g. FABF_ECOLI P39435 3-oxoacyl-[acyl-carrier-protein] synthase II (412 aa) from Escherichia coli, fasta scores: E(): 1.5e-68, 49.286% identity in 420 aa overlap | Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase, N-terminal domain and PF02801 ketoacyl-synt_C, Beta-ketoacyl synthase, C-terminal domain; 3-oxoacyl-ACP synthase	complement(369755..371026)	Ehrlichia ruminantium str. Welgevonden	3233315
YP_180085.1	CDS	acpP	NC_005295.2	371039	371317	R	acpP | acyl carrier protein | len: 92 aa | Similar to several e.g. ACP_BACSU P80643 Acyl carrier protein (ACP) (77 aa) from Bacillus subtilis, fasta scores: E(): 3.6e-05, 44.595% identity in 74 aa overlap | Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site | Contains PS00012 Phosphopantetheine attachment site; Acyl carrier protein	complement(371039..371317)	Ehrlichia ruminantium str. Welgevonden	3233268
YP_180086.1	CDS	Erum2170	NC_005295.2	372165	375386	R	unknown | len: 1073 aa | Weakly similar to several repetitive eukaryotic proteins e.g. DSPP_HUMAN Q9NZW4 Dentin sialophosphoprotein precursor (1253 aa) from Homo sapiens, fasta scores: E(): 1.2e-08, 19.508% identity in 651 aa overlap | Contains a tandem repeat, 252 bp repeated 2.7 times (or 126 bp repeated 5.1 times); hypothetical protein	complement(372165..375386)	Ehrlichia ruminantium str. Welgevonden	3232909
YP_180087.1	CDS	Erum2180	NC_005295.2	376082	378712	D	probable integral membrane protein | len: 876 aa | Weakly similar to several eukaryotic proteins e.g. RN5A_HUMAN Q05823 2-5A-dependent ribonuclease (741 aa) from Homo sapiens, fasta scores: E(): 9.2e-07, 25.862% identity in 348 aa overlap | Contains 9 Pfam matches to entry PF00023 ank, Ankyrin repeat | Contains 2 probable transmembrane helices predicted by TMHMM2.0 at aa 722-744 and 765-787; hypothetical protein	376082..378712	Ehrlichia ruminantium str. Welgevonden	3232910
YP_180088.1	CDS	rpmG	NC_005295.2	378705	378875	R	in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33	complement(378705..378875)	Ehrlichia ruminantium str. Welgevonden	3232689
YP_180089.1	CDS	Erum2200	NC_005295.2	379119	379826	D	probable integral membrane protein | len: 235 aa | Contains 6 probable transmembrane helices predicted by TMHMM2.0 at aa 12-34, 44-66, 73-95, 110-132, 145-167 and 196-218; phosphatidylglycerophosphatase A	379119..379826	Ehrlichia ruminantium str. Welgevonden	3232911
YP_180090.1	CDS	dsbB	NC_005295.2	379828	380310	D	possible dsbB | possible disulfide bond formation protein B | len: 160 aa | Similar to 2 hypothetical proteins e.g. Y370_RICPR Q9ZDF9 Hypothetical protein RP370 (172 aa) from Rickettsia prowazekii, fasta scores: E(): 1.9e-09, 25.714% identity in 175 aa overlap. Weakly similar to several DsbB proteins e.g. DSBB_ECOLI P30018 Disulfide bond formation protein B (176 aa) from Escherichia coli, fasta scores: E(): 0.28, 25.714% identity in 175 aa overlap | Contains Pfam match to entry PF02600 DsbB, Disulfide bond formation protein DsbB | Contains 4 probable transmembrane helices predicted by TMHMM2.0 at aa 12-34, 44-58, 63-85 and 131-153; hypothetical protein	379828..380310	Ehrlichia ruminantium str. Welgevonden	3233452
YP_180091.1	CDS	Erum2220	NC_005295.2	380294	380806	D	unknown | len: 170 aa | Similar to several eukaryotic proteins e.g. COQ7_HUMAN Q99807 Ubiquinone biosynthesis protein COQ7 homolog (217 aa) from Homo sapiens, fasta scores: E(): 1.5e-24, 48.503% identity in 167 aa overlap | Contains 2 Pfam matches to entry PF03232 COQ7, Ubiquinone biosynthesis protein COQ7; hypothetical protein	380294..380806	Ehrlichia ruminantium str. Welgevonden	3232912
YP_180092.1	CDS	mnmA	NC_005295.2	381487	382599	R	catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA	complement(381487..382599)	Ehrlichia ruminantium str. Welgevonden	3232747
YP_180093.1	CDS	Erum2240	NC_005295.2	383468	384577	R	probable membrane protein | len: 369 aa | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 15-37. The transmembrane helix could represent a possible N-terminal signal sequence. | Similar to Erum2290; hypothetical protein	complement(383468..384577)	Ehrlichia ruminantium str. Welgevonden	3232913
YP_180094.1	CDS	Erum2250	NC_005295.2	386285	387328	R	probable membrane protein | len: 347 aa | Contains PS00881 Protein splicing signature | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 20-42. The transmembrane helix could represent a possible N-terminal signal sequence. | Similar to Erum2400, Erum2260, Erum2410, Erum2330, Erum2310, Erum2350, Erum2340; hypothetical protein	complement(386285..387328)	Ehrlichia ruminantium str. Welgevonden	3232914
YP_180095.1	CDS	Erum2260	NC_005295.2	388344	389285	R	probable membrane protein | len: 313 aa | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 5-27. The transmembrane helix could represent a possible N-terminal signal sequence. | Similar to Erum2250, Erum2400, Erum2410, Erum2330, Erum2340, Erum2350, Erum2310, Erum2320, Erum2270; hypothetical protein	complement(388344..389285)	Ehrlichia ruminantium str. Welgevonden	3232915
YP_180096.1	CDS	Erum2270	NC_005295.2	390158	391312	R	probable membrane protein | len: 384 aa | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 7-29. The transmembrane helix could represent a possible N-terminal signal sequence. | Similar to Erum2290, Erum2280; hypothetical protein	complement(390158..391312)	Ehrlichia ruminantium str. Welgevonden	3232916
YP_180097.1	CDS	Erum2280	NC_005295.2	393120	394145	R	probable membrane protein | len: 341 aa | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 7-29. The transmembrane helix could represent a possible N-terminal signal sequence. | Similar to Erum2290, Erum2270, Erum2300; hypothetical protein	complement(393120..394145)	Ehrlichia ruminantium str. Welgevonden	3232917
YP_180098.1	CDS	Erum2290	NC_005295.2	394434	395462	R	probable membrane protein | len: 342 aa | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 4-23. The transmembrane helix could represent a possible N-terminal signal sequence. | Similar to Erum2280, Erum2270, Erum2240; hypothetical protein	complement(394434..395462)	Ehrlichia ruminantium str. Welgevonden	3232918
YP_180099.1	CDS	Erum2300	NC_005295.2	395908	397020	R	probable membrane protein | len: 370 aa | Contains predicted helix-turn-helix motif | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 13-35; hypothetical protein	complement(395908..397020)	Ehrlichia ruminantium str. Welgevonden	3232919
YP_180100.1	CDS	Erum2310	NC_005295.2	397560	398513	D	probable membrane protein | possible exported protein | len: 317 aa | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.961) with cleavage site probability 0.818 between residues 20 and 21. The signal peptide could represent a transmembrane helix | Similar to Erum2330, Erum2340, Erum2320, Erum2350, Erum2410, Erum2260, Erum2400, Erum2250 suggests this is a member of a membrane protein family; membrane protein or exported protein	397560..398513	Ehrlichia ruminantium str. Welgevonden	3232920
YP_180101.1	CDS	Erum2320	NC_005295.2	398968	399891	D	probable membrane protein | possible exported protein | len: 307 aa | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.985) with cleavage site probability 0.807 between residues 29 and 30. The signal peptide could represent a transmembrane helix | Similarity to Erum2310, Erum2330, Erum2340, Erum2350, Erum2410, Erum2400, Erum2260 suggests this is a member of a membrane protein family; hypothetical protein	398968..399891	Ehrlichia ruminantium str. Welgevonden	3232921
YP_180102.1	CDS	Erum2330	NC_005295.2	400307	401227	D	probable membrane protein | len: 306 aa | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 7-29. The transmembrane helix could represent a possible N-terminal signal sequence. | Similar to Erum2310, Erum2340, Erum2350, Erum2320, Erum2400, Erum2260, Erum2250, Erum2410; hypothetical protein	400307..401227	Ehrlichia ruminantium str. Welgevonden	3232922
YP_180103.1	CDS	Erum2340	NC_005295.2	401651	402631	D	probable membrane protein | len: 326 aa | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 7-29. The transmembrane helix could represent a possible N-terminal signal sequence. | Similar to Erum2330, Erum2350, Erum2310, Erum2320, Erum2400, Erum2260, Erum2410, Erum2250; hypothetical protein	401651..402631	Ehrlichia ruminantium str. Welgevonden	3232923
YP_180104.1	CDS	Erum2370	NC_005295.2	405858	407111	R	unknown | len: 417 aa; hypothetical protein	complement(405858..407111)	Ehrlichia ruminantium str. Welgevonden	3232925
YP_180105.1	CDS	Erum2380	NC_005295.2	407153	408151	R	unknown | len: 332 aa; hypothetical protein	complement(407153..408151)	Ehrlichia ruminantium str. Welgevonden	3232926
YP_180106.1	CDS	uvrD	NC_005295.2	408503	410422	R	uvrD | DNA helicase II | len: 639 aa | Highly similar to many e.g. UVRD_ECOLI P03018 DNA helicase II (720 aa) from Escherichia coli, fasta scores: E(): 2e-69, 39.658% identity in 643 aa overlap | Contains Pfam match to entry PF00580 UvrD-helicase, UvrD/REP helicase | Contains PS00017 ATP/GTP-binding site motif A (P-loop); DNA helicase II	complement(408503..410422)	Ehrlichia ruminantium str. Welgevonden	3232795
YP_180107.1	CDS	Erum2400	NC_005295.2	410978	412153	R	probable membrane protein | len: 391 aa | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 5-27. The transmembrane helix could represent a possible N-terminal signal sequence. | Contains a tandem repeat, 90 bp repeated 2.0 times | Similar to Erum2410, Erum2250, Erum2260, Erum2330, Erum2340, Erum2350, Erum2310, Erum2320; hypothetical protein	complement(410978..412153)	Ehrlichia ruminantium str. Welgevonden	3232927
YP_180108.1	CDS	Erum2410	NC_005295.2	412491	413471	R	probable membrane protein | len: 326 aa | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 13-35. The transmembrane helix could represent a possible N-terminal signal sequence. | Similar to Erum2400, Erum2250, Erum2260, Erum2320, Erum2310, Erum2330, Erum2350, Erum2340; hypothetical protein	complement(412491..413471)	Ehrlichia ruminantium str. Welgevonden	3232928
YP_180109.1	CDS	gyrA	NC_005295.2	415358	418054	D	negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A	415358..418054	Ehrlichia ruminantium str. Welgevonden	3233355
YP_180110.1	CDS	nth	NC_005295.2	418074	418706	D	nth | endonuclease III | len: 210 aa | Highly similar to many e.g. END3_ECOLI P20625 Endonuclease III (211 aa) from Escherichia coli, fasta scores: E(): 4.1e-41, 51.923% identity in 208 aa overlap | Contains Pfam match to entry PF00730 HhH-GPD, HhH-GPD superfamily base excision DNA repair protein | Contains PS00764 Endonuclease III iron-sulfur binding region signature; endonuclease III	418074..418706	Ehrlichia ruminantium str. Welgevonden	3233416
YP_180111.1	CDS	Erum2440	NC_005295.2	418973	419635	D	probable integral membrane protein | len: 220 aa | Contains 2 probable transmembrane helices predicted by TMHMM2.0 at aa 7-29 and 34-53; hypothetical protein	418973..419635	Ehrlichia ruminantium str. Welgevonden	3232929
YP_180112.1	CDS	htpG	NC_005295.2	419708	421621	D	molecular chaperone; heat shock protein 90	419708..421621	Ehrlichia ruminantium str. Welgevonden	3233367
YP_180113.1	CDS	purB	NC_005295.2	422169	423467	R	Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase	complement(422169..423467)	Ehrlichia ruminantium str. Welgevonden	3232629
YP_180114.1	CDS	Erum2470	NC_005295.2	425783	426859	D	probable integral membrane protein | len: 358 aa | Contains 2 probable transmembrane helices predicted by TMHMM2.0 at aa 73-95 and 115-137 | Similar to Erum2480; integral membrane protein	425783..426859	Ehrlichia ruminantium str. Welgevonden	3232930
YP_180115.1	CDS	Erum2480	NC_005295.2	428148	429254	D	probable integral membrane protein | len: 368 aa | Contains 3 probable transmembrane helices predicted by TMHMM2.0 at aa 12-31, 58-80 and 100-122 | Similar to Erum2470; integral membrane protein	428148..429254	Ehrlichia ruminantium str. Welgevonden	3232931
YP_180116.1	CDS	Erum2490	NC_005295.2	429954	432449	R	unknown | len: 831 aa | Similar to Erum2510, Erum2500; hypothetical protein	complement(429954..432449)	Ehrlichia ruminantium str. Welgevonden	3232932
YP_180117.1	CDS	Erum2500	NC_005295.2	433014	433931	R	unknown | len: 305 aa | Similar to Erum2490, Erum2510; hypothetical protein	complement(433014..433931)	Ehrlichia ruminantium str. Welgevonden	3232933
YP_180118.1	CDS	Erum2510	NC_005295.2	434510	436933	R	unknown | len: 807 aa | Termed cpg1 in Louw et al. (2002) Ann. N.Y. Acad. Sci. 969: 147-150 | Similar to Erum2490, Erum2500; hypothetical protein	complement(434510..436933)	Ehrlichia ruminantium str. Welgevonden	3232934
YP_180119.1	CDS	Erum2520	NC_005295.2	437389	438147	R	probable biotin--[acetyl-CoA-carboxylase] synthetase | len: 252 aa | Similar to many of similar length e.g. BIRA_PARDE P29906 Biotin--[acetyl-CoA-carboxylase] synthetase (240 aa) from Paracoccus denitrificans, fasta scores: E(): 9.7e-14, 30.126% identity in 239 aa overlap. Similar to the C-terminus of many others e.g. BIRA_BACSU P42975 BirA bifunctional protein (325 aa) from Bacillus subtilis, fasta scores: E(): 1e-18, 29.796% identity in 245 aa overlap and BIRA_ECOLI P06709 BirA bifunctional protein from Escherichia coli, fasta scores: E(): 1.8e-08, 28.163% identity in 245 aa overlap | Contains Pfam match to entry PF03099 BPL_LipA_LipB, Biotin/lipoate A/B protein ligase family and PF02237 BPL_C, Biotin protein ligase C terminal domain, incomplete domain. There is no obvious DNA binding domain.; biotin-protein ligase	complement(437389..438147)	Ehrlichia ruminantium str. Welgevonden	3232935
YP_180120.1	CDS	Erum2530	NC_005295.2	438555	439280	R	probable glutathione S-transferase | len: 241 aa | Similar to many uncharacterized bacterial proteins e.g. Q9A2C6 Glutathione S-transferase family protein (228 aa) from Caulobacter crescentus, fasta scores: E(): 1.7e-29, 39.910% identity in 223 aa overlap. Also similar to many eukaryotic proteins e.g. GTH2_YEAST Q12390 Glutathione S-transferase II (233 aa) from Saccharomyces cerevisiae, fasta scores: E(): 2.3e-06, 25.121% identity in 207 aa overlap | Contains Pfam match to entry PF02798 GST_N, Glutathione S-transferase, N-terminal domain and PF00043 GST_C, Glutathione S-transferase, C-terminal domain | C-terminus ends within a tandem repeat, 155 bp repeated 3.0 times; hypothetical protein	complement(438555..439280)	Ehrlichia ruminantium str. Welgevonden	3232936
YP_180121.1	CDS	Erum2540	NC_005295.2	440268	440795	R	probable exported protein | len: 175 aa | Weakly similar to e.g. Q9ZN94 OrfA protein (Fragment) (104 aa) from Wolbachia sp., fasta scores: E(): 7.6e-11, 39.806% identity in 103 aa overlap | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.777) with cleavage site probability 0.414 between residues 22 and 23; hypothetical protein	complement(440268..440795)	Ehrlichia ruminantium str. Welgevonden	3232937
YP_180122.1	CDS	Erum2550	NC_005295.2	441239	442261	D	probable ABC transporter, ATP-binding protein | len: 340 aa | Similar to many e.g. FBPC_ECOLI P37009 Ferric cations import ATP-binding protein FbpC (348 aa) from Escherichia coli, fasta scores: E(): 1.9e-32, 33.934% identity in 333 aa overlap | Contains Pfam match to entry PF00005 ABC_tran, ABC transporter | Contains PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop) | Similar to Erum0580, Erum1190, Erum5760, Erum6820, Erum6270, Erum7050, Erum2590; spermidine/putrescine ABC transporter ATP-binding protein	441239..442261	Ehrlichia ruminantium str. Welgevonden	3232938
YP_180123.1	CDS	tatA	NC_005295.2	442296	442466	D	possible tatA | possible Sec-independent protein translocase membrane protein | len: 56 aa | Similar to several uncharacterized TatA proteins e.g. TAT2_AQUAE O66477 Sec-independent protein translocase (59 aa) from Aquifex aeolicus, fasta scores: E(): 6e-06, 63.158% identity in 38 aa overlap | Contains Pfam match to entry PF02416 MttA_Hcf106, mttA/Hcf106 family | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 5-22; Sec-independent protein translocase membrane protein	442296..442466	Ehrlichia ruminantium str. Welgevonden	3233465
YP_180124.1	CDS	recR	NC_005295.2	442689	443276	D	involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR	442689..443276	Ehrlichia ruminantium str. Welgevonden	3232592
YP_180125.1	CDS	Erum2580	NC_005295.2	444399	445262	R	probable ABC transporter, periplasmic solute binding protein | len: 287 aa | Similar to many e.g. ZNUA_ECOLI P39172 High-affinity zinc uptake system protein (310 aa) from Escherichia coli, fasta scores: E(): 1.9e-08, 27.362% identity in 307 aa overlap | Contains Pfam match to entry PF01297 SBP_bac_9, Periplasmic solute binding protein family | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 7-29. The transmembrane helix could represent a possible N-terminal signal sequence.; high-affinity zinc uptake system protein znuA	complement(444399..445262)	Ehrlichia ruminantium str. Welgevonden	3232939
YP_180126.1	CDS	Erum2590	NC_005295.2	445254	445982	D	probable ABC transporter, ATP-binding protein | len: 242 aa | Similar to many e.g. ZNUC_ECOLI P52648 High-affinity zinc uptake system ATP-binding protein ZnuC (251 aa) from Escherichia coli, fasta scores: E(): 9.8e-24, 36.111% identity in 216 aa overlap | Contains Pfam match to entry PF00005 ABC_tran, ABC transporter | Contains PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature | Similar to Erum1190; high-affinity zinc uptake system ATP-binding protein znuC	445254..445982	Ehrlichia ruminantium str. Welgevonden	3232940
YP_180127.1	CDS	ubiB	NC_005295.2	445975	447417	D	probable ubiB | probable ubiquinone biosynthesis protein UbiB | len: 480 aa | Similar to many e.g. UBIB_ECOLI P27854 Probable ubiquinone biosynthesis protein ubiB (546 aa) from Escherichia coli, fasta scores: E(): 1.1e-19, 34.475% identity in 467 aa overlap | Contains Pfam match to entry PF03109 ABC1, ABC1 family | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 7-29 | C-terminus ends within a tandem repeat, 221 bp repeated 2.0 times; ubiquinone biosynthesis protein	445975..447417	Ehrlichia ruminantium str. Welgevonden	3232619
YP_180128.1	CDS	Erum2610	NC_005295.2	447642	448847	D	probable integral membrane protein | len: 401 aa | Similar to several e.g. Q9RG52  transport protein (387 aa) from Legionella pneumophila, fasta scores: E(): 2.8e-15, 22.222% identity in 369 aa overlap | Contains 12 probable transmembrane helices predicted by TMHMM2.0 at aa 7-29, 39-61, 74-93, 98-120, 133-155, 165-182, 218-240, 255-277, 284-301, 305-327, 339-361 and 371-393 | N-terminus starts within a tandem repeat, 221 bp repeated 2.0 times | Similar to Erum6780; hypothetical protein	447642..448847	Ehrlichia ruminantium str. Welgevonden	3232941
YP_180129.1	CDS	Erum2620	NC_005295.2	449463	450800	R	catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase	complement(449463..450800)	Ehrlichia ruminantium str. Welgevonden	3232942
YP_180130.1	CDS	Erum2630	NC_005295.2	452753	456361	R	unknown | len: 1202 aa | Similar to the N-terminus of Q9A4Q6 Hypothetical protein CC2774 (514 aa) from Caulobacter crescentus, fasta scores: E(): 8.6e-17; 31.806% identity in 371 aa overlap | C-terminus ends within a tandem repeat, 375 bp repeated 2.1 times (or 187 bp repeated 4.2 times); hypothetical protein	complement(452753..456361)	Ehrlichia ruminantium str. Welgevonden	3232943
YP_180131.1	CDS	Erum2640	NC_005295.2	457609	458433	R	conserved hypothetical protein | len: 274 aa | Similar to three others from Alphaproteobacteria e.g. Q8UGS0 Hypothetical protein Atu0965 (294 aa) from Agrobacterium tumefaciens, fasta scores: E(): 8.9e-20, 29.562% identity in 274 aa overlap; hypothetical protein	complement(457609..458433)	Ehrlichia ruminantium str. Welgevonden	3232944
YP_180132.1	CDS	sucA	NC_005295.2	459166	461907	D	SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1	459166..461907	Ehrlichia ruminantium str. Welgevonden	3232730
YP_180133.1	CDS	Erum2660	NC_005295.2	463241	464476	R	unknown | len: 411 aa | Similar to several uncharacterized phage proteins e.g. Q8W627  major capsid protein (407 aa) from Bacteriophage P27, fasta scores: E(): 9.5e-24, 28.571% identity in 413 aa overlap; hypothetical protein	complement(463241..464476)	Ehrlichia ruminantium str. Welgevonden	3232945
YP_180134.1	CDS	dapA	NC_005295.2	464666	465556	R	catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase	complement(464666..465556)	Ehrlichia ruminantium str. Welgevonden	3233302
YP_180135.1	CDS	Erum2680	NC_005295.2	465915	466256	R	probable HIT-like protein | len: 113 aa | Similar to many uncharacterized proteins e.g. YHIT_RICPR Q9ZDL1 Hypothetical HIT-like protein RP317 (120 aa) from Rickettsia prowazekii, fasta scores: E(): 2.1e-21, 53.571% identity in 112 aa overlap | Contains Pfam match to entry PF01230 HIT, HIT domain | Contains PS00892 HIT family signature; protein kinase C inhibitor 1	complement(465915..466256)	Ehrlichia ruminantium str. Welgevonden	3232946
YP_180136.1	CDS	Erum2690	NC_005295.2	466268	467326	R	unknown | len: 352 aa | Contains PS00017 ATP/GTP-binding site motif A (P-loop); hypothetical protein	complement(466268..467326)	Ehrlichia ruminantium str. Welgevonden	3232947
YP_180137.1	CDS	mutS	NC_005295.2	467517	469931	D	This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS	467517..469931	Ehrlichia ruminantium str. Welgevonden	3233412
YP_180138.1	CDS	nadE	NC_005295.2	471261	472802	R	probable nadE | probable glutamine-dependent NAD(+) synthetase | len: 513 aa | Similar to many e.g. NADE_RHOCA Q03638 Glutamine-dependent NAD(+) synthetase (552 aa) from Rhodobacter capsulatus, fasta scores: E(): 8.8e-48, 34.572% identity in 538 aa overlap | Contains Pfam match to entry PF02540 NAD_synthase, NAD synthase, but does not contain PF00795 Carbon-nitrogen hydrolase as seen in NADE_RHOCA.; glutamine-dependent NAD(+) synthetase	complement(471261..472802)	Ehrlichia ruminantium str. Welgevonden	3233530
YP_180139.1	CDS	hemB	NC_005295.2	474068	475057	R	catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase	complement(474068..475057)	Ehrlichia ruminantium str. Welgevonden	3233358
YP_180140.1	CDS	Erum2730	NC_005295.2	476906	479644	D	unknown | len: 912 aa | Weakly similar to four others from Alphaproteobacteria e.g. Q89WD7 Bll0753 protein (1048 aa) from Bradyrhizobium japonicum, fasta scores: E(): 3e-11, 20.498% identity in 1044 aa overlap; hypothetical protein	476906..479644	Ehrlichia ruminantium str. Welgevonden	3232948
YP_180141.1	CDS	Erum2740	NC_005295.2	479765	481045	D	probable integral membrane transport protein | len: 426 aa | Similar to many e.g. SHIA_ECOLI P76350 Shikimate transporter (438 aa) from Escherichia coli, fasta scores: E(): 2.7e-21, 26.570% identity in 414 aa overlap | Contains Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter | Contains 12 probable transmembrane helices predicted by TMHMM2.0 at aa 21-43, 63-85, 98-117, 127-149, 161-183, 193-215, 250-272, 277-299, 312-334, 338-360, 367-389 and 394-416 | Similar to Erum2810, Erum2820, Erum1330; integral membrane transport protein	479765..481045	Ehrlichia ruminantium str. Welgevonden	3232949
YP_180142.1	CDS	Erum2750	NC_005295.2	482423	484006	R	probable membrane protein | len: 527 aa | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 34-56 | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.991) with cleavage site probability 0.266 between residues 21 and 22 | Similar to Erum2800, Erum2770, Erum2780, Erum3630, Erum3610, Erum2760, Erum3600, Erum2790, Erum3620; hypothetical protein	complement(482423..484006)	Ehrlichia ruminantium str. Welgevonden	3232950
YP_180143.1	CDS	Erum2760	NC_005295.2	484914	486473	R	probable membrane protein | len: 519 aa | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 39-61 | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.762 between residues 25 and 26 | Similar to Erum2770, Erum2780, Erum2790, Erum2750, Erum3610, Erum3630, Erum2800; hypothetical protein	complement(484914..486473)	Ehrlichia ruminantium str. Welgevonden	3232951
YP_180144.1	CDS	Erum2770	NC_005295.2	486622	488202	R	probable membrane protein | len: 526 aa | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 38-60 | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.458 between residues 20 and 21 | Similar to Erum2760, Erum2750, Erum2780, Erum2790, Erum2800, Erum3610, Erum3620, Erum3630, Erum3600; hypothetical protein	complement(486622..488202)	Ehrlichia ruminantium str. Welgevonden	3232952
YP_180145.1	CDS	Erum2780	NC_005295.2	488444	490018	R	probable membrane protein | len: 524 aa | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 34-56 | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.823) with cleavage site probability 0.371 between residues 23 and 24 | Contains a tandem repeat, 21 bp repeated 2.0 times | Similar to Erum2750, Erum2770, Erum2760, Erum2790, Erum3630, Erum2800, Erum3610, Erum3620, Erum3600; hypothetical protein	complement(488444..490018)	Ehrlichia ruminantium str. Welgevonden	3232953
YP_180146.1	CDS	Erum2790	NC_005295.2	490196	492157	R	probable integral membrane protein | len: 653 aa | Contains 2 probable transmembrane helices predicted by TMHMM2.0 at aa 10-32 and 44-63. The initial transmembrane helix could represent a possible N-terminal signal sequence. | Similar to Erum2770, Erum2760, Erum2780, Erum2750, Erum3630, Erum2800, Erum3610, Erum3620, Erum3600; hypothetical protein	complement(490196..492157)	Ehrlichia ruminantium str. Welgevonden	3232954
YP_180147.1	CDS	Erum2800	NC_005295.2	492695	494257	R	probable membrane protein | len: 520 aa | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 34-56 | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.971) with cleavage site probability 0.738 between residues 42 and 43 | Similar to Erum2750, Erum3610, Erum3630, Erum2770, Erum2780, Erum3620, Erum3600, Erum2790, Erum2760; hypothetical protein	complement(492695..494257)	Ehrlichia ruminantium str. Welgevonden	3232955
YP_180148.1	CDS	Erum2810	NC_005295.2	495433	496686	D	probable integral membrane transport protein | len: 417 aa | Similar to many e.g. SHIA_ECOLI P76350 Shikimate transporter (438 aa) from Escherichia coli, fasta scores: E(): 6.2e-22, 29.117% identity in 419 aa overlap | Contains Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter | Contains 12 probable transmembrane helices predicted by TMHMM2.0 at aa 7-26, 46-68, 80-102, 112-134,143-165, 180-199, 233-255, 265-284, 291-313, 317-339, 352-374 and 378-400 | Similar to Erum2740, Erum2820, Erum1330; integral membrane transport protein	495433..496686	Ehrlichia ruminantium str. Welgevonden	3232956
YP_180149.1	CDS	Erum2820	NC_005295.2	498533	499780	D	probable integral membrane transport protein | len: 415 aa | Similar to many e.g. SHIA_ECOLI P76350 Shikimate transporter (438 aa) from Escherichia coli, fasta scores: E(): 2.3e-21, 27.865% identity in 384 aa overlap | Contains Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter | Contains 12 probable transmembrane helices predicted by TMHMM2.0 at aa 12-34, 49-71, 80-99, 109-131, 144-166, 181-200, 236-258, 263-285, 292-314, 318-340, 352-374 and 379-401 | Similar to Erum2810, Erum2740, Erum1330; integral membrane transport protein	498533..499780	Ehrlichia ruminantium str. Welgevonden	3232957
YP_180150.1	CDS	ssb	NC_005295.2	501494	501964	R	ssb | single-strand DNA binding protein | len: 156 aa | Similar to many e.g. SSB_ECOLI P02339 Single-strand binding protein (177 aa) from Escherichia coli, fasta scores: E(): 1.2e-20, 52.137% identity in 117 aa overlap | Contains Pfam match to entry PF00436 SSB, Single-strand binding protein family | Contains PS00735 Single-strand binding protein family signature 1 and PS00736 Single-strand binding protein family signature 2; single-strand binding protein	complement(501494..501964)	Ehrlichia ruminantium str. Welgevonden	3232729
YP_180151.1	CDS	matA	NC_005295.2	502112	503494	D	probable matA | probable malonyl-CoA decarboxylase | len: 460 aa | Similar to several e.g. Q9ZIP6 Malonyl-CoA decarboxylase (462 aa) from Rhizobium leguminosarum, fasta scores: E(): 1e-33, 36.719% identity in 384 aa overlap | Contains Pfam match to entry PF05292 MCD, Malonyl-CoA decarboxylase (MCD) | C-terminus is almost identical to Erum2880; hypothetical protein	502112..503494	Ehrlichia ruminantium str. Welgevonden	3233525
YP_180152.1	CDS	gatB	NC_005295.2	503532	504977	D	allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B	503532..504977	Ehrlichia ruminantium str. Welgevonden	3233334
YP_180153.1	CDS	fabI	NC_005295.2	505475	506296	D	fabI | enoyl-[acyl-carrier-protein] reductase [NADH] | len: 273 aa | Highly similar to many e.g. FABI_ECOLI P29132 Enoyl-[acyl-carrier-protein] reductase [NADH] (261 aa) from Escherichia coli, fasta scores: E(): 6.6e-42, 43.191% identity in 257 aa overlap | Contains Pfam match to entry PF00106 adh_short, short chain dehydrogenase | Similar to Erum3840; enoyl-ACP reductase	505475..506296	Ehrlichia ruminantium str. Welgevonden	3233318
YP_180154.1	CDS	dnaA	NC_005295.2	506593	507987	D	binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosome replication initiator DnaA	506593..507987	Ehrlichia ruminantium str. Welgevonden	3233306
YP_180155.1	CDS	Erum2900	NC_005295.2	509243	510238	R	probable integral membrane protein | len: 331 aa | Contains 2 probable transmembrane helices predicted by TMHMM2.0 at aa 231-253 and 257-279; hypothetical protein	complement(509243..510238)	Ehrlichia ruminantium str. Welgevonden	3232960
YP_180156.1	CDS	nadD	NC_005295.2	510535	511119	D	probable nadD | probable nicotinate-nucleotide adenylyltransferase | len: 194 aa | Similar to many e.g. NADD_BACSU P54455 Probable nicotinate-nucleotide adenylyltransferase (189 aa) from Bacillus subtilis, fasta scores: E(): 2e-08, 25.316% identity in 158 aa overlap | Contains Pfam match to entry PF01467 CTP_transf_2, Cytidylyltransferase; nicotinate-nucleotide adenylyltransferase	510535..511119	Ehrlichia ruminantium str. Welgevonden	3233529
YP_180157.1	CDS	pdxJ	NC_005295.2	511573	512289	D	involved in the de novo synthesis of pyridoxine (Vitamin B6); pyridoxine 5'-phosphate synthase	511573..512289	Ehrlichia ruminantium str. Welgevonden	3233436
YP_180158.1	CDS	hupB	NC_005295.2	512276	512560	R	probable hupB | probable DNA-binding protein HU-beta | len: 94 aa | Weakly similar to several e.g. DBHB_ECOLI PP02341 DNA-binding protein HU-beta (90 aa) from Escherichia coli, fasta scores: E(): 0.0017, 27.778% identity in 90 aa overlap | Contains Pfam match to entry PF00216 Bac_DNA_binding, Bacterial DNA-binding protein; DNA-binding protein HU	complement(512276..512560)	Ehrlichia ruminantium str. Welgevonden	3233514
YP_180159.1	CDS	holB	NC_005295.2	512873	513763	R	possible holB | possible DNA polymerase III, delta prime subunit | len: 296 aa | Weakly similar to several e.g. Q9RQJ8 DNA polymerase III delta prime subunit (335 aa) from Caulobacter crescentus, fasta scores: E(): 2.4e-08, 30.851% identity in 188 aa overlap | Similar to Erum0040; DNA polymerase III subunit gamma	complement(512873..513763)	Ehrlichia ruminantium str. Welgevonden	3233457
YP_180160.1	CDS	Erum2950	NC_005295.2	514775	515374	R	conserved hypothetical protein | len: 199 aa | Similar to many e.g. YCIO_ECOLI P45847 Protein yciO (206 aa) from Escherichia coli, fasta scores: E(): 3.1e-09, 27.807% identity in 187 aa overlap | Contains Pfam match to entry PF01300 Sua5_yciO_yrdC, yrdC domain | N-terminus starts within a tandem repeat, 144 bp repeated 6.0 times; hypothetical protein	complement(514775..515374)	Ehrlichia ruminantium str. Welgevonden	3232961
YP_180161.1	CDS	coaE	NC_005295.2	516667	517272	D	probable coaE | probable dephospho-CoA kinase | len: 201 aa | Similar to several uncharacterized proteins e.g. COAE_RHIME Q92TE9 Dephospho-CoA kinase (194 aa) from Rhizobium meliloti, fasta scores: E(): 4.9e-14, 31.156% identity in 199 aa overlap and weakly similar to many e.g. COAE_ECOLI P36679 Dephospho-CoA kinase (206 aa) from Escherichia coli, fasta scores: E(): 0.00039, 24.599% identity in 187 aa overlap | Contains Pfam match to entry PF01121 CoaE, Dephospho-CoA kinase | Contains PS00017 ATP/GTP-binding site motif A (P-loop); dephospho-CoA kinase	516667..517272	Ehrlichia ruminantium str. Welgevonden	3233479
YP_180162.1	CDS	thiC	NC_005295.2	519169	520836	R	required for the synthesis of the hydromethylpyrimidine moiety of thiamine; thiamine biosynthesis protein ThiC	complement(519169..520836)	Ehrlichia ruminantium str. Welgevonden	3232737
YP_180163.1	CDS	Erum2980	NC_005295.2	521186	521746	R	unknown | len: 186 aa | Weakly similar to several e.g. Q9A227 Smr family protein (189 aa) from Caulobacter crescentus, fasta scores: E(): 2.4e-07, 26.923% identity in 182 aa overlap | Contains Pfam match to entry PF01713 Smr, Smr domain; hypothetical protein	complement(521186..521746)	Ehrlichia ruminantium str. Welgevonden	3232962
YP_180164.1	CDS	rpoZ	NC_005295.2	521892	522290	R	probable rpoZ | probable DNA-directed RNA polymerase omega chain | len: 132 aa | Weakly similar to several e.g. RPOZ_AGRT5 Q8UGK8 Probable DNA-directed RNA polymerase omega chain (129 aa) from Agrobacterium tumefaciens, fasta scores: E(): 4e-07, 33.628% identity in 113 aa overlap and weakly similar to the N-terminus of several e.g. RPOZ_ECOLI P08374 DNA-directed RNA polymerase omega chain (91 aa) from Escherichia coli, fasta scores: E(): 0.0048, 37.500% identity in 64 aa overlap | Contains Pfam match to entry PF01192 RNA_pol_Rpb6, RNA polymerase Rpb6; DNA-directed RNA polymerase omega chain	complement(521892..522290)	Ehrlichia ruminantium str. Welgevonden	3232599
YP_180165.1	CDS	Erum3000	NC_005295.2	522379	522750	R	unknown | len: 123 aa | Contains PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2; hypothetical protein	complement(522379..522750)	Ehrlichia ruminantium str. Welgevonden	3232963
YP_180166.1	CDS	leuS	NC_005295.2	523155	525647	D	leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase	523155..525647	Ehrlichia ruminantium str. Welgevonden	3233378
YP_180167.1	CDS	Erum3030	NC_005295.2	527287	528072	D	possible deoxyribonuclease | len: 261 aa | Similar to many uncharacterized proteins e.g. YCFH_ECOLI P37346 deoxyribonuclease YcfH (265 aa) from Escherichia coli, fasta scores: E(): 2.7e-37, 42.353% identity in 255 aa overlap | Contains Pfam match to entry PF01026 TatD_DNase, TatD related DNase | Contains PS01137 TATD_1 TatD deoxyribonuclease family signature 1; deoxyribonuclease	527287..528072	Ehrlichia ruminantium str. Welgevonden	3232965
YP_180168.1	CDS	pyrF	NC_005295.2	529288	529983	D	pyrF | orotidine 5'-phosphate decarboxylase | len: 231 aa | Similar to many e.g. PYRF_ECOLI P08244 Orotidine 5'-phosphate decarboxylase (245 aa) from Escherichia coli, fasta scores: E(): 1.8e-23, 37.118% identity in 229 aa overlap | Contains Pfam match to entry PF00215 OMPdecase, Orotidine 5'-phosphate decarboxylase/HUMPS family | Contains PS00156 Orotidine 5'-phosphate decarboxylase active site; orotidine 5'-phosphate decarboxylase	529288..529983	Ehrlichia ruminantium str. Welgevonden	3232642
YP_180169.1	CDS	surE	NC_005295.2	531074	531832	D	surE | acid phosphatase SurE | len: 252 aa | Similar to many e.g. SURE_ECOLI P36664 Acid phosphatase surE (253 aa) from Escherichia coli, fasta scores: E(): 2.3e-19, 33.977% identity in 259 aa overlap | Contains Pfam match to entry PF01975 SurE, Survival protein SurE; acid phosphatase SurE	531074..531832	Ehrlichia ruminantium str. Welgevonden	3232734
YP_180170.1	CDS	ccmE	NC_005295.2	531963	532367	D	CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane; cytochrome c-type biogenesis protein CcmE	531963..532367	Ehrlichia ruminantium str. Welgevonden	3233293
YP_180171.1	CDS	nuoC	NC_005295.2	533283	533858	R	probable nuoC | probable NADH-quinone oxidoreductase chain C | len: 191 aa | Similar to many e.g. NQO5_PARDE P29917 NADH-quinone oxidoreductase chain 5 (206 aa) from Paracoccus denitrificans, fasta scores: E(): 4.1e-32, 49.198% identity in 187 aa overlap and NUOC_RICPR Q9ZDH3 NADH-quinone oxidoreductase chain C (197 aa) from Rickettsia prowazekii, fasta scores: E(): 1.6e-25, 40.957% identity in 188 aa overlap | Contains Pfam match to entry PF00329 complex1_30Kd, Respiratory-chain NADH dehydrogenase, 30 Kd subunit | C-terminal region is almost identical to Erum3080; NADH-quinone oxidoreductase chain C	complement(533283..533858)	Ehrlichia ruminantium str. Welgevonden	3232573
YP_180172.1	CDS	nuoB	NC_005295.2	535356	535874	R	The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B	complement(535356..535874)	Ehrlichia ruminantium str. Welgevonden	3233417
YP_180173.1	CDS	nuoA	NC_005295.2	535881	536252	R	probable nuoA | probable NADH-quinone oxidoreductase chain A | len: 123 aa | Similar to many e.g. NQO7_PARDE P29919 NADH-quinone oxidoreductase chain 7 (121 aa) from Paracoccus denitrificans, fasta scores: E(): 3.5e-25, 52.586% identity in 116 aa overlap and NUOA_RICCN Q92ID5 NADH-quinone oxidoreductase chain A (123 aa) from Rickettsia conorii, fasta scores: E(): 3.4e-26, 62.069% identity in 116 aa overlap | Contains Pfam match to entry PF00507 oxidored_q4, NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 | Contains 3 probable transmembrane helices predicted by TMHMM2.0 at aa 31-53, 83-105 and 112-134; NADH-quinone oxidoreductase chain A	complement(535881..536252)	Ehrlichia ruminantium str. Welgevonden	3233533
YP_180174.1	CDS	uvrA	NC_005295.2	536881	539760	R	uvrA | uvrABC system protein A | len: 959 aa | Highly similar to many e.g. UVRA_HAEIN P44410 UvrABC system protein A (943 aa) from Haemophilus influenzae, fasta scores: E(): 4.5e-127, 51.346% identity in 966 aa overlap | Contains 2 Pfam matches to entry PF00005 ABC_tran, ABC transporter | Contains PS00211 ABC transporters family signature and 2 PS00017 ATP/GTP-binding site motif A (P-loop); excinuclease ABC subunit A	complement(536881..539760)	Ehrlichia ruminantium str. Welgevonden	3232794
YP_180175.1	CDS	Erum3120	NC_005295.2	539970	540494	R	unknown | len: 174 aa | Weakly similar to e.g. NUSB_RICPR Q9ZE01 N utilization substance protein B homolog (NusB protein) (155 aa) from Rickettsia prowazekii, fasta scores: E(): 4.8e-05, 28.966% identity in 145 aa overlap | Contains Pfam match to entry PF01029 NusB, NusB family; N utilization substance protein B-like protein	complement(539970..540494)	Ehrlichia ruminantium str. Welgevonden	3232967
YP_180176.1	CDS	ribH	NC_005295.2	540499	540948	R	RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase	complement(540499..540948)	Ehrlichia ruminantium str. Welgevonden	3232594
YP_180177.1	CDS	Erum3140	NC_005295.2	540968	542695	R	functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; inner membrane protein translocase component YidC	complement(540968..542695)	Ehrlichia ruminantium str. Welgevonden	3232968
YP_180178.1	CDS	Erum3150	NC_005295.2	543760	545145	R	probable integral membrane transport protein | len: 461 aa | Similar to many e.g. YAAJ_ECOLI P30143 transporter yaaJ (476 aa) from Escherichia coli, fasta scores: E(): 8.2e-26, 26.068% identity in 468 aa overlap | Contains Pfam match to entry PF01235 Na_Ala_symp, Sodium:alanine symporter family | Contains 11 probable transmembrane helices predicted by TMHMM2.0 at aa 20-42, 78-100, 105-127, 163-182, 197-219, 232-249, 259-281, 319-341, 363-385, 397-416 and 426-44 | Similar to Erum5810; integral membrane transport protein	complement(543760..545145)	Ehrlichia ruminantium str. Welgevonden	3232969
YP_180179.1	CDS	pssA	NC_005295.2	545170	545952	R	probable pssA | probable CDP-diacylglycerol--serine O-phosphatidyltransferase | len: 260 aa | Similar to many e.g. PSS_BACSU P39823 CDP-diacylglycerol--serine O-phosphatidyltransferase (177 aa) from Bacillus subtilis, fasta scores: E(): 6.8e-11, 34.965% identity in 143 aa overlap | Contains Pfam match to entry PF01066 CDP-OH_P_transf, CDP-alcohol phosphatidyltransferase | Contains PS00379 CDP-alcohol phosphatidyltransferases signature | Contains 7 probable transmembrane helices predicted by TMHMM2.0 at aa 15-37, 44-61, 94-116, 137-159, 179-201, 206-223 and 228-250; CDP-diacylglycerol--serine O-phosphatidyltransferase	complement(545170..545952)	Ehrlichia ruminantium str. Welgevonden	3232583
YP_180180.1	CDS	psd	NC_005295.2	545955	546638	R	catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine; phosphatidylserine decarboxylase	complement(545955..546638)	Ehrlichia ruminantium str. Welgevonden	3232582
YP_180181.1	CDS	Erum3180	NC_005295.2	549143	552547	R	unknown | len: 1134 aa | Similar to several e.g. Q82W40 Hypothetical protein (1183 aa) from Nitrosomonas europaea, fasta scores: E(): 5.4e-115, 48.021% identity in 1162 aa overlap | Contains PS00190 Cytochrome c family heme-binding site signature | C-terminus ends within a tandem repeat, 182 bp repeated 4.4 times; hypothetical protein	complement(549143..552547)	Ehrlichia ruminantium str. Welgevonden	3232972
YP_180182.1	CDS	efp	NC_005295.2	553107	553676	D	probable efp | probable elongation factor P | len: 189 aa | Similar to many e.g. EFP_ECOLI P33398 Elongation factor P (187 aa) from Escherichia coli, fasta scores: E(): 6.6e-10, 26.776% identity in 183 aa overlap | Contains Pfam match to entry PF01132 EFP, Elongation factor P (EF-P); elongation factor P (EF-P)	553107..553676	Ehrlichia ruminantium str. Welgevonden	3233495
YP_180183.1	CDS	suhB	NC_005295.2	553838	554608	D	probable suhB | probable inositol-1-monophosphatase | len: 256 aa | Similar to many e.g. SUHB_ECOLI P22783 Inositol-1-monophosphatase (267 aa) from Escherichia coli, fasta scores: E(): 7.3e-08, 22.368% identity in 228 aa overlap | Contains Pfam match to entry PF00459 inositol_P, Inositol monophosphatase family; inositol monophosphatase	553838..554608	Ehrlichia ruminantium str. Welgevonden	3232607
YP_180184.1	CDS	rluC	NC_005295.2	555611	556528	D	probable rluC | probable ribosomal large subunit pseudouridine synthase C | len: 305 aa | Similar to many e.g. RLUC_ECOLI P23851 Ribosomal large subunit pseudouridine synthase C (319 aa) from Escherichia coli, fasta scores: E(): 5.3e-19, 28.526% identity in 312 aa overlap | Contains Pfam match to entry PF00849 PseudoU_synth_2, RNA pseudouridylate synthase and PF01479 S4, S4 domain | Contains PS01129 Rlu family of pseudouridine synthase signature | Similar to Erum5330; ribosomal large subunit pseudouridine synthase C	555611..556528	Ehrlichia ruminantium str. Welgevonden	3232596
YP_180185.1	CDS	pleD	NC_005295.2	556907	558292	R	involved in swarmer-to-stalked cell differentiation in Caulobacter crescentus; catalyzes the condensation of two GTP molecules to form the secondary messenger cyclic di-GMP (c-di-GMP); upon phosphorylation of domain D1 the protein dimerizes; presumably this allows the two GTP-bound GGDEF (diguanylate cyclase) domains to catalyze the condensation reaction; allosterically inhibited by c-di-GMP; response regulator PleD	complement(556907..558292)	Ehrlichia ruminantium str. Welgevonden	3232973
YP_180186.1	CDS	Erum3221	NC_005295.2	558289	558570	R	unknown | len: 93 aa; hypothetical protein	complement(558289..558570)	Ehrlichia ruminantium str. Welgevonden	3232974
YP_180187.1	CDS	Erum3230	NC_005295.2	558582	563351	R	possible NAD-glutamate dehydrogenase | len: 1589 aa | Similar to several hypothetical proteins and uncharacterized proteins that have been termed NAD-glutamate dehydrogenase e.g. Q9ZCI2 Hypothetical protein RP758 (1581 aa) from Rickettsia prowazekii, fasta scores: E(): 3e-177, 35.719% identity in 1593 aa overlap | Contains Pfam match to entry PF05088 Bac_GDH, Bacterial NAD-glutamate dehydrogenase; hypothetical protein	complement(558582..563351)	Ehrlichia ruminantium str. Welgevonden	3232975
YP_180188.1	CDS	Erum3240	NC_005295.2	563952	564584	D	probable integral membrane protein | len: 210 aa | Similar to several e.g. EXOD_RHIME Q52923 ExoD protein (240 aa) from Rhizobium meliloti, fasta scores: E(): 1.2e-12, 27.604% identity in 192 aa overlap | Contains Pfam match to entry PF06055 ExoD, Exopolysaccharide synthesis | Contains 4 probable transmembrane helices predicted by TMHMM2.0 at aa 33-52, 62-84, 131-153 and 173-195; hypothetical protein	563952..564584	Ehrlichia ruminantium str. Welgevonden	3232976
YP_180189.1	CDS	cysS	NC_005295.2	564581	565954	D	catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase	564581..565954	Ehrlichia ruminantium str. Welgevonden	3233301
YP_180190.1	CDS	Erum3260	NC_005295.2	566922	568868	R	unknown | len: 648 aa | Almost identical to Q93FT6 Hypothetical 72.9 kDa protein (648 aa) from Ehrlichia ruminantium (Highway), fasta scores: E(): 0, 99.691% identity in 648 aa overlap; hypothetical protein	complement(566922..568868)	Ehrlichia ruminantium str. Welgevonden	3232977
YP_180191.1	CDS	nrdF	NC_005295.2	569185	570159	D	B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta	569185..570159	Ehrlichia ruminantium str. Welgevonden	3233532
YP_180192.1	CDS	Erum3280	NC_005295.2	572183	572467	R	conserved hypothetical protein | len: 94 aa | Similar to three other rickettsial proteins e.g. EAA25622 Hypothetical protein (107 aa) from Rickettsia sibirica, fasta scores: E(): 6.3e-13, 43.000% identity in 100 aa overlap; hypothetical protein	complement(572183..572467)	Ehrlichia ruminantium str. Welgevonden	3232978
YP_180193.1	CDS	Erum3290	NC_005295.2	572473	573057	R	unknown | len: 194 aa; hypothetical protein	complement(572473..573057)	Ehrlichia ruminantium str. Welgevonden	3232979
YP_180194.1	CDS	Erum3300	NC_005295.2	573128	574147	D	conserved hypothetical protein | len: 339 aa | Similar to many e.g. Q98HW7 Hypothetical protein mlr2680 (362 aa) from Rhizobium loti, fasta scores: E(): 1.2e-37, 33.824% identity in 340 aa overlap | Contains Pfam match to entry PF02636 DUF185, Uncharacterized ACR; hypothetical protein	573128..574147	Ehrlichia ruminantium str. Welgevonden	3232980
YP_180195.1	CDS	dnaG	NC_005295.2	575253	577031	D	probable dnaG | probable DNA primase | len: 592 aa | Similar to many e.g. PRIM_RICPR P30103 DNA primase (593 aa) from Rickettsia prowazekii, fasta scores: E(): 5.3e-31, 33.775% identity in 604 aa overlap. Similar to N-terminus of PRIM_ECOLI P02923 DNA primase (581 aa) from Escherichia coli, fasta scores: E(): 7.8e-11, 33.253% identity in 415 aa overlap | Contains Pfam match to entry PF01807 zf-CHC2, CHC2 zinc finger and PF01751 Toprim, Toprim domain; DNA primase	575253..577031	Ehrlichia ruminantium str. Welgevonden	3233491
YP_180196.1	CDS	rpoD	NC_005295.2	578492	580360	R	rpoD | RNA polymerase sigma-70 factor | len: 622 aa | Highly similar to many e.g. RPSD_ECOLI P00579 RNA polymerase sigma factor RpoD (613 aa) from Escherichia coli, fasta scores: E(): 5e-73, 42.229% identity in 637 aa overlap | Contains Pfam match to entry PF03979 sigma70_r1_1, Sigma-70 factor, PF00140 sigma70_r1_2, Sigma-70 factor, region 1.2, PF04546 sigma70_ner, Sigma-70, non-essential region, PF04542 sigma70_r2, Sigma-70 region 2, PF04539 sigma70_r3, Sigma-70 region 3 and PF04545 sigma70_r4, Sigma-70, region 4 | Contains PS00715 Sigma-70 factors family signature 1 and PS00716 Sigma-70 factors family signature 2 | Contains 3 predicted helix-turn-helix motifs | Similar to Erum3960; RNA polymerase sigma factor rpoD	complement(578492..580360)	Ehrlichia ruminantium str. Welgevonden	3232696
YP_180197.1	CDS	Erum3330	NC_005295.2	581013	581966	R	conserved hypothetical protein | len: 317 aa | Similar to many uncharacterized proteins e.g. P45672 NifR3-like protein (328 aa) from Azospirillum brasilense, fasta scores: E(): 5.4e-66, 56.958% identity in 309 aa overlap | Contains Pfam match to entry PF01207 Dus, Dihydrouridine synthase (Dus) | Contains PS01136 Uncharacterized protein family UPF0034 signature; nitrogen regulation protein nifR3	complement(581013..581966)	Ehrlichia ruminantium str. Welgevonden	3232981
YP_180198.1	CDS	ispE	NC_005295.2	582906	583751	D	An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	582906..583751	Ehrlichia ruminantium str. Welgevonden	3233519
YP_180199.1	CDS	cutA	NC_005295.2	583951	584280	R	probable cutA | probable periplasmic divalent cation tolerance protein CutA | len: 109 aa | Similar to many e.g. CUTA_ECOLI P36654 Periplasmic divalent cation tolerance protein cutA (112 aa) from Escherichia coli, fasta scores: E(): 6.8e-07, 31.313% identity in 99 aa overlap | Contains Pfam match to entry PF03091 CutA1, CutA1 divalent ion tolerance protein; periplasmic divalent cation tolerance protein	complement(583951..584280)	Ehrlichia ruminantium str. Welgevonden	3233483
YP_180200.1	CDS	Erum3360	NC_005295.2	584395	586881	R	probable two component sensor kinase | len: 828 aa | Similar to many uncharacterized proteins e.g. Q8UFN5 two component sensor kinase (861 aa) from Agrobacterium tumefaciens, fasta scores: E(): 1.8e-56, 31.621% identity in 876 aa overlap | Contains Pfam match to PF00512 HisKA, His Kinase A (phosphoacceptor) domain, PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase and PF00072 response_reg, response regulator receiver domain | Contains 3 probable transmembrane helices predicted by TMHMM2.0 at aa 24-46, 51-73 and 655-677 | Note that the sensor kinase and response regulator receiver domains, normally found in separate proteins in bacterial two-component systems, are both present in Erum3360. There is no obvious DNA-binding domain.; histidine kinase sensor protein	complement(584395..586881)	Ehrlichia ruminantium str. Welgevonden	3232982
YP_180201.1	CDS	mdmC	NC_005295.2	586993	587649	R	probable mdmC | probable O-methyltransferase | len: 218 aa | Similar to many e.g. MDMC_STRMY Q00719 O-methyltransferase (221 aa) from Streptomyces mycarofaciens, fasta scores: E(): 8e-10, 29.834% identity in 181 aa overlap | Contains Pfam match to entry PF01596 Methyltransf_3, O-methyltransferase | Contains PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature; O-methyltransferase	complement(586993..587649)	Ehrlichia ruminantium str. Welgevonden	3233526
YP_180202.1	CDS	Erum3380	NC_005295.2	587893	588177	D	unknown | len: 94 aa; hypothetical protein	587893..588177	Ehrlichia ruminantium str. Welgevonden	3232983
YP_180203.1	CDS	Erum3390	NC_005295.2	588280	589683	D	conserved hypothetical protein | len: 467 aa | Similar to many e.g. YJEF_ECOLI P31806 Hypothetical protein yjeF (515 aa) from Escherichia coli, fasta scores: E(): 3e-20, 29.158% identity in 463 aa overlap | Contains Pfam match to entry PF03853 yjeF_N, yjeF-related protein and PF01256 carb_kinase, carbohydrate kinase | Contains PS00092 N-6 Adenine-specific DNA methylases signature and PS01050 Uncharacterized protein family UPF0031 signature 2; hypothetical protein	588280..589683	Ehrlichia ruminantium str. Welgevonden	3232984
YP_180204.1	CDS	topA	NC_005295.2	590829	593288	D	topA | DNA topoisomerase I | len: 819 aa | Highly similar to many e.g. TOP1_ECOLI P06612 DNA topoisomerase I (865 aa) from Escherichia coli, fasta scores: E(): 2.6e-37, 40.572% identity in 769 aa overlap | Contains Pfam match to entry PF01751 Toprim, Toprim domain, PF01131 Topoisom_bac, DNA topoisomerase and PF01396 zf-C4_Topoisom, Topoisomerase DNA binding C4 zinc finger | Contains PS00396 prokaryotic DNA topoisomerase I active site; DNA topoisomerase I	590829..593288	Ehrlichia ruminantium str. Welgevonden	3232743
YP_180205.1	CDS	Erum3410	NC_005295.2	593627	593986	R	unknown | len: 119 aa | Weakly similar to Q8U541 AGR_C_4407p (359 aa) from Agrobacterium tumefaciens, fasta scores: E(): 5.1e-05, 24.771% identity in 109 aa overlap; hypothetical protein	complement(593627..593986)	Ehrlichia ruminantium str. Welgevonden	3232985
YP_180206.1	CDS	Erum3420	NC_005295.2	594239	594700	R	conserved hypothetical protein | len: 153 aa | Similar to several from Alphaproteobacteria e.g. EAA26169 hypothetical protein (157 aa) from Rickettsia sibirica, fasta scores: E(): 1.6e-11, 31.081% identity in 148 aa overlap; hypothetical protein	complement(594239..594700)	Ehrlichia ruminantium str. Welgevonden	3232986
YP_180207.1	CDS	acpS	NC_005295.2	596527	596898	R	Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase	complement(596527..596898)	Ehrlichia ruminantium str. Welgevonden	3233471
YP_180208.1	CDS	proS	NC_005295.2	596900	598180	R	catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase	complement(596900..598180)	Ehrlichia ruminantium str. Welgevonden	3232625
YP_180209.1	CDS	Erum3450	NC_005295.2	598768	599751	R	probable exported protein | len: 327 aa | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.612 between residues 21 and 22. The signal peptide could represent a possible transmembrane helix. | Similar to Erum5370; hypothetical protein	complement(598768..599751)	Ehrlichia ruminantium str. Welgevonden	3232987
YP_180210.1	CDS	coaD	NC_005295.2	600036	600533	D	Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase	600036..600533	Ehrlichia ruminantium str. Welgevonden	3233478
YP_180211.1	CDS	trxB	NC_005295.2	602550	603506	R	trxB | thioredoxin reductase | len: 318 aa | Highly similar to many e.g. TRXB_ECOLI P09625 Thioredoxin reductase (320 aa) from Escherichia coli, fasta scores: E(): 7.6e-51, 50.949% identity in 316 aa overlap | Contains Pfam match to PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase | Contains PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site | Similar to Erum4020, Erum5130; thioredoxin reductase	complement(602550..603506)	Ehrlichia ruminantium str. Welgevonden	3232787
YP_180212.1	CDS	Erum3480	NC_005295.2	603507	604124	R	probable peroxiredoxin | len: 205 aa | Highly similar to many uncharacterized proteins e.g. Q9ZDK1 thioredoxin peroxidase 1 (200 aa) from Rickettsia prowazekii, fasta scores: E(): 1.6e-41, 51.269% identity in 197 aa overlap | Contains Pfam match to entry PF00578 AhpC-TSA, AhpC/TSA family | Similar to Erum4880; peroxiredoxin (26 kDa antigen)	complement(603507..604124)	Ehrlichia ruminantium str. Welgevonden	3232988
YP_180213.1	CDS	aatA	NC_005295.2	604510	605709	D	aatA | aspartate aminotransferase A | len: 399 aa | Highly similar to many e.g. AATA_RHIME Q02635 Aspartate aminotransferase A (400 aa) from Rhizobium meliloti, fasta scores: E(): 7.3e-74, 51.010% identity in 396 aa overlap | Contains Pfam match to entry PF00155 aminotran_1_2, Aminotransferase class I and II | Contains PS00105 aminotransferases class-I pyridoxal-phosphate attachment site; aspartate aminotransferase	604510..605709	Ehrlichia ruminantium str. Welgevonden	3233266
YP_180214.1	CDS	ppiD	NC_005295.2	607319	609211	R	probable ppiD | probable peptidyl-prolyl cis-trans isomerase D | len: 630 aa | Similar to many e.g. PPID_ECOLI P77241 Peptidyl-prolyl cis-trans isomerase D (623 aa) from Escherichia coli, fasta scores: E(): 1.1e-12, 21.672% identity in 646 aa overlap | Contains Pfam match to entry PF00639 Rotamase, PPIC-type PPIASE domain | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 7-29. The transmembrane helix could represent a possible N-terminal signal sequence. | Contains predicted helix-turn-helix motif; peptidyl-prolyl cis-trans isomerase D	complement(607319..609211)	Ehrlichia ruminantium str. Welgevonden	3232580
YP_180215.1	CDS	Erum3510	NC_005295.2	609552	610133	R	possible glycoprotease | len: 193 aa | Weakly similar to many uncharacterized proteases e.g. YEAZ_ECOLI P76256 Hypothetical protease yeaZ (231 aa) from Escherichia coli, fasta scores: E(): 1.7e-06, 32.558% identity in 129 aa overlap | Contains Pfam match to entry PF00814 Peptidase_M22, Glycoprotease family; hypothetical protein	complement(609552..610133)	Ehrlichia ruminantium str. Welgevonden	3232989
YP_180216.1	CDS	truB	NC_005295.2	612383	613273	D	probable truB | probable tRNA pseudouridine synthase B | len: 296 aa | Similar to many uncharacterized proteins e.g. TRUB_CAUCR P58063 tRNA pseudouridine synthase B (310 aa) from Caulobacter crescentus, fasta scores: E(): 1.1e-40, 41.528% identity in 301 aa overlap. Similar to the N-terminus of TRUB_ECOLI P09171 tRNA pseudouridine synthase B (314 aa) from Escherichia coli, fasta scores: E(): 1.1e-24, 36.792% identity in 212 aa overlap | Contains Pfam match to entry PF01509 TruB_N, TruB family pseudouridylate synthase (N terminal domain); tRNA pseudouridine synthase B	612383..613273	Ehrlichia ruminantium str. Welgevonden	3232617
YP_180217.1	CDS	rpsO	NC_005295.2	613292	613573	D	primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15	613292..613573	Ehrlichia ruminantium str. Welgevonden	3232712
YP_180218.1	CDS	pnp	NC_005295.2	613606	615975	D	pnp | polyribonucleotide nucleotidyltransferase | len: 789 aa | Highly similar to many e.g. PNP_ECOLI P05055 Polyribonucleotide nucleotidyltransferase (711 aa) from Escherichia coli, fasta scores: E(): 8e-93, 48.442% identity in 706 aa overlap | Contains 2 Pfam matches to entry PF01138 RNase_PH, 3' exoribonuclease family, domain 1, 2 matches to entry PF03725 RNase_PH_C, 3' exoribonuclease family, domain 2, PF03726 PNPase, polyribonucleotide nucleotidyltransferase, RNA binding domain, PF00013 KH, KH domain and PF00575 S1, S1 RNA binding domain; polynucleotide phosphorylase	613606..615975	Ehrlichia ruminantium str. Welgevonden	3233445
YP_180219.1	CDS	Erum3550	NC_005295.2	616005	616802	D	conserved hypothetical protein | len: 265 aa | Similar to several e.g. Q9A9Y0 Hypothetical protein CC0831 (303 aa) from Caulobacter crescentus, fasta scores: E(): 6.1e-22, 32.090% identity in 268 aa overlap; hypothetical protein	616005..616802	Ehrlichia ruminantium str. Welgevonden	3232990
YP_180220.1	CDS	lepA	NC_005295.2	616834	618630	D	binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA	616834..618630	Ehrlichia ruminantium str. Welgevonden	3233377
YP_180221.1	CDS	Erum3570	NC_005295.2	619159	620289	D	probable integral membrane protein | len: 376 aa | Contains 2 probable transmembrane helices predicted by TMHMM2.0 at aa 5-27 and 37-59 | Contains a tandem repeat, 12 bp repeated 3.2 times; hypothetical protein	619159..620289	Ehrlichia ruminantium str. Welgevonden	3232991
YP_180222.1	CDS	Erum3580	NC_005295.2	620863	621429	D	probable integral membrane protein | len: 188 aa | Contains 2 probable transmembrane helices predicted by TMHMM2.0 at aa 9-28 and 38-60. The initial transmembrane helix could represent a possible N-terminal signal sequence.; hypothetical protein	620863..621429	Ehrlichia ruminantium str. Welgevonden	3232992
YP_180223.1	CDS	Erum3590	NC_005295.2	621836	623005	D	probable integral membrane protein | len: 389 aa | Contains 2 probable transmembrane helices predicted by TMHMM2.0 at aa 11-33 and 40-62 | Contains two tandem repeats, 45 bp repeated 7.4 times, 42 bp repeated 2.1 times; hypothetical protein	621836..623005	Ehrlichia ruminantium str. Welgevonden	3232993
YP_180224.1	CDS	Erum3600	NC_005295.2	624287	626044	D	probable integral membrane protein | len: 585 aa | Similar in the repetitive region to several uncharacterized proteins e.g. O33899 M-like protein (374 aa) from Streptococcus equi, fasta scores: E(): 7.5e-08, 65.625% identity in 64 aa overlap | Contains 2 probable transmembrane helices predicted by TMHMM2.0 at aa 10-32 and 44-66. The initial transmembrane helix could represent a possible N-terminal signal sequence. | Contains a tandem repeat, 12 bp repeated 16.7 times (or 6 bp repeated 19.3 times) | Similar to Erum2750, Erum3610, Erum3630, Erum2800, Erum2780, Erum3620, Erum2770, Erum2790; hypothetical protein	624287..626044	Ehrlichia ruminantium str. Welgevonden	3232994
YP_180225.1	CDS	Erum3610	NC_005295.2	627956	629497	R	probable membrane protein | len: 513 aa | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 35-57 | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.980) with cleavage site probability 0.499 between residues 28 and 29. The signal peptide could represent a possible transmembrane helix. | Similar to Erum3630, Erum2800, Erum3620, Erum2750, Erum2770, Erum2760, Erum3600, Erum2780, Erum2790; hypothetical protein	complement(627956..629497)	Ehrlichia ruminantium str. Welgevonden	3232996
YP_180226.1	CDS	Erum3620	NC_005295.2	630600	632213	R	probable integral membrane protein | len: 537 aa | Contains 2 probable transmembrane helices predicted by TMHMM2.0 at aa 26-43 and 55-77. The initial transmembrane helix could represent a possible N-terminal signal sequence. | Similar to Erum3630, Erum3610, Erum2800, Erum2780, Erum2770, Erum3600, Erum2790, Erum2750; hypothetical protein	complement(630600..632213)	Ehrlichia ruminantium str. Welgevonden	3232997
YP_180227.1	CDS	Erum3630	NC_005295.2	633289	634848	R	probable membrane protein | len: 519 aa | Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 34-56 | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.483 between residues 54 and 55. The signal peptide could represent a possible transmembrane helix. | Similar to Erum3610, Erum3620, Erum2800, Erum2750, Erum3600, Erum2780, Erum2790, Erum2770, Erum2760; hypothetical protein	complement(633289..634848)	Ehrlichia ruminantium str. Welgevonden	3232998
YP_180228.1	CDS	Erum3640	NC_005295.2	636091	636426	D	unknown | len: 111 aa; hypothetical protein	636091..636426	Ehrlichia ruminantium str. Welgevonden	3232999
YP_180229.1	CDS	prfB	NC_005295.2	638210	639314	R	prfB | peptide chain release factor 2 | len: 367 aa | Highly similar to many e.g. RF2_ECOLI Peptide chain release factor 2 (365 aa) from Escherichia coli, fasta scores: E(): 4.5e-67, 45.251% identity in 358 aa overlap | Contains Pfam match to entry PF00472 RF-1, peptidyl-tRNA hydrolase domain and PF03462 PCRF, peptide chain release factor domain | Contains PS00745 Prokaryotic-type class I peptide chain release factors signature | Contains natural frameshift at the UGA termination codon after Leu-25 | Similar to Erum4500; peptide chain release factor 2	complement(join(638210..639238,639240..639314))	Ehrlichia ruminantium str. Welgevonden	3233469
YP_180230.1	CDS	Erum3660	NC_005295.2	640113	640862	R	conserved hypothetical protein | len: 249 aa | Similar to many e.g. YR53_RHIME Q92M88 Hypothetical UPF0082 protein R02753 (248 aa) from Rhizobium meliloti, fasta scores: E(): 1.1e-41, 51.029% identity in 243 aa overlap | Contains Pfam match to entry PF01709 DUF28, domain of unknown function; hypothetical protein	complement(640113..640862)	Ehrlichia ruminantium str. Welgevonden	3233000
YP_180231.1	CDS	gatA	NC_005295.2	640876	642339	R	allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A	complement(640876..642339)	Ehrlichia ruminantium str. Welgevonden	3233333
YP_180232.1	CDS	folC	NC_005295.2	643152	644447	D	probable folC | probable folylpolyglutamate synthase/dihydrofolate synthase | len: 431 aa | Similar to many e.g. FOLC_ECOLI P08192 FolC bifunctional protein (422 aa) from Escherichia coli, fasta scores: E(): 2.3e-23, 33.816% identity in 414 aa overlap | Contains Pfam match to entry PF01225 Mur_ligase, Mur ligase family, catalytic domain | Contains PS01011 Folylpolyglutamate synthase signature 1 and PS01012 Folylpolyglutamate synthase signature 2; folylpolyglutamate synthase	643152..644447	Ehrlichia ruminantium str. Welgevonden	3233504
YP_180233.1	CDS	hemC	NC_005295.2	645592	646491	D	transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase	645592..646491	Ehrlichia ruminantium str. Welgevonden	3233359
YP_180234.1	CDS	typA	NC_005295.2	647275	649113	D	probable typA | probable GTP-binding protein TypA/BipA | len: 612 aa | Highly similar to many e.g. TYPA_ECOLI P32132 GTP-binding protein typA/BipA (591 aa) from Escherichia coli, fasta scores: E(): 3.6e-105, 52.811% identity in 587 aa overlap | Contains Pfam match to entry PF00009 GTP_EFTU, Elongation factor Tu GTP binding domain, PF03144 GTP_EFTU_D2, Elongation factor Tu domain 2 and PF00679 EFG_C, Elongation factor G C-terminus | Contains PS00017 ATP/GTP-binding site motif A (P-loop) and PS00301 GTP-binding elongation factors signature | Similar to Erum3560, Erum1650, Erum1660, Erum6090, Erum4690; GTP-binding protein TypA	647275..649113	Ehrlichia ruminantium str. Welgevonden	3232618
YP_180235.1	CDS	Erum3701	NC_005295.2	650356	650676	D	unknown | len: 106 aa; hypothetical protein	650356..650676	Ehrlichia ruminantium str. Welgevonden	3233001
YP_180236.1	CDS	nuoI	NC_005295.2	651435	651941	R	Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I	complement(651435..651941)	Ehrlichia ruminantium str. Welgevonden	3233423
YP_180237.1	CDS	sipF	NC_005295.2	651950	652666	R	sipF | prokaryotic type I signal peptidase | len: 238 aa | Similar to many e.g. O69160 prokaryotic type I signal peptidase sipF (254 aa) from Bradyrhizobium japonicum, fasta scores: E(): 9.3e-40, 49.793% identity in 241 aa overlap | Contains Pfam match to entry PF00461 Peptidase_S26, Signal peptidase I | Contains PS00501 Signal peptidases I serine active site, PS00760 Signal peptidases I lysine active site and PS00761 Signal peptidases I signature 3 | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 7-29; Signal peptidase I	complement(651950..652666)	Ehrlichia ruminantium str. Welgevonden	3232726
YP_180238.1	CDS	Erum3730	NC_005295.2	652681	653142	R	unknown | len: 153 aa | Contains Pfam match to entry PF01521 HesB-like, HesB-like domain | Contains PS01152, Hypothetical hesB/yadR/yfhF family signature | Contains a tandem repeat, 27 bp repeated 2.2 times; hypothetical protein	complement(652681..653142)	Ehrlichia ruminantium str. Welgevonden	3233002
YP_180239.1	CDS	Erum3740	NC_005295.2	653196	654407	D	probable metal dependent phosphohydrolase | len: 403 aa | Similar to many uncharacterized proteins e.g. DGT1_CAUCR Q9A6S5 Deoxyguanosinetriphosphate triphosphohydrolase-like protein (394 aa) from Caulobacter crescentus, fasta scores: E(): 6.3e-70, 46.329% identity in 395 aa overlap. Weakly similar to DGTP_ECOLI P15723 Deoxyguanosinetriphosphate triphosphohydrolase (504 aa) from Escherichia coli, fasta scores: E(): 0.0032, 23.579% identity in 475 aa overlap | Contains Pfam match to entry PF01966 HD, HD domain; deoxyguanosinetriphosphate triphosphohydrolase-like protein	653196..654407	Ehrlichia ruminantium str. Welgevonden	3233003
YP_180240.1	CDS	Erum3750	NC_005295.2	654668	659692	D	unknown | len: 1674 aa | Similar to ankyrin repeat reqions in Q9APN7 43 kDa surface protein (390 aa) from Ehrlichia canis, fasta scores: E(): 2.8e-13, 27.735% identity in 393 aa overlap | Contains 19 Pfam matches to entry PF00023 ank, Ankyrin repeat | Contains PS00017 ATP/GTP-binding site motif A (P-loop) | Contains two tandem repeats, 27 bp repeated 8.3 times, 144 bp repeated 3.9 times; hypothetical protein	654668..659692	Ehrlichia ruminantium str. Welgevonden	3233004
YP_180241.1	CDS	Erum3760	NC_005295.2	661099	662025	D	probable integral membrane protein | len: 308 aa | Contains 6 probable transmembrane helices predicted by TMHMM2.0 at aa 39-61, 71-93, 116-138, 148-170, 201-223 and 238-260; hypothetical protein	661099..662025	Ehrlichia ruminantium str. Welgevonden	3233005
YP_180242.1	CDS	argG	NC_005295.2	662414	663598	R	catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming; argininosuccinate synthase	complement(662414..663598)	Ehrlichia ruminantium str. Welgevonden	3233275
YP_180243.1	CDS	Erum3780	NC_005295.2	663767	664438	D	probable exported protein | len: 223 aa | Contains signal peptide predicted by SignalP 2.0 HMM (probability 0.987) with cleavage site probability 0.962 between residues 22 and 23; hypothetical protein	663767..664438	Ehrlichia ruminantium str. Welgevonden	3233006
YP_180244.1	CDS	Erum3790	NC_005295.2	665023	665730	D	probable exported protein | len: 235 aa | Contains signal peptide predicted by SignalP 2.0 HMM (probability 0.966) with cleavage site probability 0.774 between residues 27 and 28. The signal peptide could represent a possible transmembrane helix.; hypothetical protein	665023..665730	Ehrlichia ruminantium str. Welgevonden	3233007
YP_180245.1	CDS	argJ	NC_005295.2	667420	668679	D	bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate; bifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein	667420..668679	Ehrlichia ruminantium str. Welgevonden	3233277
YP_180246.1	CDS	exoA	NC_005295.2	668689	669525	D	probable exoA | probable exodeoxyribonuclease | len: 278 aa | Similar to many uncharacterized proteins that have been termed exodeoxyribonuclease III e.g. Q9ZCP7 exodeoxyribonuclease III (XTHA2) (269 aa) from Rickettsia prowazekii, fasta scores: E(): 3.6e-25, 39.927% identity in 273 aa overlap. Weakly similar to EXOA_STRPN P21998 Exodeoxyribonuclease (275 aa) from Streptococcus pneumoniae, fasta scores: E(): 5.6e-07, 26.756% identity in 299 aa overlap | Contains Pfam match to entry PF03372 Exo_endo_phos, Endonuclease/Exonuclease/phosphatase family | Contains PS00728 apurinic/apyrimidinic endonucleases family 1 signature 3; exodeoxyribonuclease III	668689..669525	Ehrlichia ruminantium str. Welgevonden	3233500
YP_180247.1	CDS	Erum3820	NC_005295.2	671042	671824	R	probable integral membrane protein | len: 260 aa | Contains 6 probable transmembrane helices predicted by TMHMM2.0 at aa 12-34, 49-71, 92-114, 124-146, 167-189 and 199-218; hypothetical protein	complement(671042..671824)	Ehrlichia ruminantium str. Welgevonden	3233008
YP_180248.1	CDS	Erum3830	NC_005295.2	673031	673861	R	probable integral membrane protein | len: 276 aa | Contains 6 probable transmembrane helices predicted by TMHMM2.0 at aa 13-35, 45-67, 93-115, 130-152,171-193 and 220-242. The initial transmembrane helix could represent a possible N-terminal signal sequence.; hypothetical protein	complement(673031..673861)	Ehrlichia ruminantium str. Welgevonden	3233009
YP_180249.1	CDS	fabG	NC_005295.2	673872	674609	R	fabG | 3-oxoacyl-[acyl carrier protein] reductase | len: 245 aa | Highly similar to many e.g. FABG_ECOLI P25716 3-oxoacyl-[acyl-carrier protein] reductase (244 aa) from Escherichia coli, fasta scores: E(): 7.5e-38, 47.521% identity in 242 aa overlap | Contains Pfam match to entry PF00106 adh_short, short chain dehydrogenase | Contains PS00061 short-chain dehydrogenases/reductases family signature | Similar to Erum6410, Erum2860; 3-oxoacyl-ACP reductase	complement(673872..674609)	Ehrlichia ruminantium str. Welgevonden	3233316
YP_180250.1	CDS	putA	NC_005295.2	675354	678485	D	proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichia coli this protein self regulates transcription via a DNA-binding domain at the N-terminus but the proteins from this group do not and in addition appear to have a truncated C-terminal domain; bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase	675354..678485	Ehrlichia ruminantium str. Welgevonden	3232638
YP_180251.1	CDS	Erum3860	NC_005295.2	679005	679520	R	probable membrane protein | len: 171 aa | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 10-32. The transmembrane helix could represent a possible N-terminal signal sequence.; hypothetical protein	complement(679005..679520)	Ehrlichia ruminantium str. Welgevonden	3233010
YP_180252.1	CDS	bioA	NC_005295.2	680828	682105	R	bioA | adenosylmethionine-8-amino-7-oxononanoate aminotransferase | len: 425 aa | Highly similar to many e.g. BIOA_ECOLI Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (429 aa) from Escherichia coli, fasta scores: E(): 5.8e-73, 45.585% identity in 419 aa overlap | Contains Pfam match to entry PF00202 aminotran_3, Aminotransferase class-III | Contains PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site | Similar to Erum2110; adenosylmethionine-8-amino-7-oxononanoate aminotransferase	complement(680828..682105)	Ehrlichia ruminantium str. Welgevonden	3233287
YP_180253.1	CDS	Erum3880	NC_005295.2	683813	685228	R	conserved hypothetical protein | len: 471 aa | Similar to several e.g. Q92ID2 Hypothetical protein RC0488 (183 aa) from Rickettsia conorii, fasta scores: E(): 8.6e-32, 54.819% identity in 166 aa overlap; hypothetical protein	complement(683813..685228)	Ehrlichia ruminantium str. Welgevonden	3233011
YP_180254.1	CDS	Erum3890	NC_005295.2	685964	686344	R	unknown | len: 126 aa | Similar to Erum3900; hypothetical protein	complement(685964..686344)	Ehrlichia ruminantium str. Welgevonden	3233012
YP_180255.1	CDS	Erum3900	NC_005295.2	686489	687058	R	unknown | len: 189 aa | Similar to Erum3890; hypothetical protein	complement(686489..687058)	Ehrlichia ruminantium str. Welgevonden	3233013
YP_180256.1	CDS	Erum3910	NC_005295.2	687116	687505	R	unknown | len: 129 aa; hypothetical protein	complement(687116..687505)	Ehrlichia ruminantium str. Welgevonden	3233014
YP_180257.1	CDS	Erum3920	NC_005295.2	687483	687893	R	unknown | len: 136 aa; hypothetical protein	complement(687483..687893)	Ehrlichia ruminantium str. Welgevonden	3233015
YP_180258.1	CDS	Erum3930	NC_005295.2	687890	688456	R	unknown | len: 188 aa; hypothetical protein	complement(687890..688456)	Ehrlichia ruminantium str. Welgevonden	3233016
YP_180259.1	CDS	Erum3940	NC_005295.2	688494	688841	R	unknown | len: 115 aa; hypothetical protein	complement(688494..688841)	Ehrlichia ruminantium str. Welgevonden	3233017
YP_180260.1	CDS	rpmJ	NC_005295.2	689204	689332	D	smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group do not have the motif; 50S ribosomal protein L36	689204..689332	Ehrlichia ruminantium str. Welgevonden	3232692
YP_180261.1	CDS	rpoH	NC_005295.2	690509	691399	R	rpoH | RNA polymerase sigma-32 factor | len: 296 aa | Similar to many e.g. RP32_ECOLI P00580 RNA polymerase sigma-32 factor (284 aa) from Escherichia coli, fasta scores: E(): 3e-32, 36.397% identity in 272 aa overlap | Contains Pfam match to entry PF04545 sigma70_r4, Sigma-70, region 4 and PF04542 sigma70_r2, Sigma-70 region 2 | Contains predicted helix-turn-helix motif | Similar to Erum3320; RNA polymerase sigma-32 factor	complement(690509..691399)	Ehrlichia ruminantium str. Welgevonden	3232697
YP_180262.1	CDS	Erum3970	NC_005295.2	691518	692114	D	unknown | len: 198 aa | Weakly similar to several uncharacterized proteins e.g. RP5M_BRAJA P30334 Probable sigma(54) modulation protein (203 aa) from Bradyrhizobium japonicum, fasta scores: E(): 8.4e-10, 26.667% identity in 195 aa overlap; sigma(54) modulation protein	691518..692114	Ehrlichia ruminantium str. Welgevonden	3233018
YP_180263.1	CDS	Erum3980	NC_005295.2	692291	701299	D	unknown | len: 3002 aa | C-terminus is weakly similar to several e.g. Q9VTN2 CG6004 protein (1444 aa) from Drosophila melanogaster, fasta scores: E(): 7.4e-06, 22.560% identity in 922 aa overlap | Contains 7 Pfam matches to entry PF00023 ank, Ankyrin repeat | Contains three tandem repeats, 144 bp repeated 2.7 times, 36 bp repeated 2.7 times, 93 bp repeated 9.2 times; hypothetical protein	692291..701299	Ehrlichia ruminantium str. Welgevonden	3233019
YP_180264.1	CDS	atpG	NC_005295.2	701378	702229	D	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; ATP synthase F0F1 subunit gamma	701378..702229	Ehrlichia ruminantium str. Welgevonden	3233286
YP_180265.1	CDS	folE	NC_005295.2	702238	702810	D	folE | GTP cyclohydrolase I | len: 190 aa | Similar to many e.g. GCH1_RICPR Q9ZDE8 GTP cyclohydrolase I (190 aa) from Rickettsia prowazekii, fasta scores: E(): 1.5e-25, 36.757% identity in 185 aa overlap and GCH1_BACSU P19465 GTP cyclohydrolase I (190 aa) from Bacillus subtilis, fasta scores: E(): 5e-16, 31.183% identity in 186 aa overlap | Contains Pfam match to entry PF01227 GTP_cyclohydroI, GTP cyclohydrolase I | Contains PS00860 GTP cyclohydrolase I signature 2; GTP cyclohydrolase I	702238..702810	Ehrlichia ruminantium str. Welgevonden	3233325
YP_180266.1	CDS	pmbA	NC_005295.2	702785	704152	D	probable pmbA | probable PmbA protein | len: 455 aa | Similar to many e.g. PMBA_ECOLI P24231 PmbA protein (TldE protein) (450 aa) from Escherichia coli, fasta scores: E(): 1.5e-26, 29.890% identity in 455 aa overlap | Contains Pfam match to entry PF01523 PmbA_TldD,  modulator of DNA gyrase | Similar to Erum1000; PmbA protein	702785..704152	Ehrlichia ruminantium str. Welgevonden	3232579
YP_180267.1	CDS	Erum4020	NC_005295.2	704653	705666	D	probable pyridine nucleotide-disulphide oxidoreductase | len: 337 aa | Similar to many proteins that have been termed thioredoxin reductase e.g. Q92HY3 Thioredoxin reductase (340 aa) from Rickettsia conorii, fasta scores: E(): 3.2e-67, 48.348% identity in 333 aa overlap | Contains Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 5-27 | Similar to Erum3470; thioredoxin reductase	704653..705666	Ehrlichia ruminantium str. Welgevonden	3233020
YP_180268.1	CDS	ksgA	NC_005295.2	706239	707027	R	catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase	complement(706239..707027)	Ehrlichia ruminantium str. Welgevonden	3233376
YP_180269.1	CDS	tpiA	NC_005295.2	707266	707988	D	Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase	707266..707988	Ehrlichia ruminantium str. Welgevonden	3232744
YP_180270.1	CDS	Erum4050	NC_005295.2	707988	708968	D	probable exported protein | len: 326 aa | Almost identical to Q93FU3 Hypothetical cell surface protein (326 aa) from Ehrlichia ruminantium (Highway), fasta scores: E(): 3.8e-117, 99.693% identity in 326 aa overlap. Similar to many immunogenic proteins e.g. BCSP_BRUME 31 kDa immunogenic protein precurser (329 aa) from Brucella abortus, fasta scores: E(): 2.4e-31, 32.609% identity in 322 aa overlap | Contains signal peptide predicted by SignalP 2.0HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.817 between residues 21 and 22; hypothetical protein	707988..708968	Ehrlichia ruminantium str. Welgevonden	3233021
YP_180271.1	CDS	gcp	NC_005295.2	708975	710021	D	in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease	708975..710021	Ehrlichia ruminantium str. Welgevonden	3233335
YP_180272.1	CDS	Erum4070	NC_005295.2	711891	712472	R	probable integral membrane protein | len: 193 aa | Weakly similar to several e.g. Y437_RICPR Q9ZDA5 Hypothetical protein RP437 (173 aa) from Rickettsia prowazekii, fasta scores: E(): 3e-06, 29.070% identity in 172 aa overlap | Contains Pfam match to entry PF06271 RDD, RDD family | Contains 3 probable transmembrane helices predicted by TMHMM2.0 at aa 34-56 | The N-terminus is similar to Erum4061; hypothetical protein	complement(711891..712472)	Ehrlichia ruminantium str. Welgevonden	3233023
YP_180273.1	CDS	folB	NC_005295.2	712679	713026	D	possible folB | possible dihydroneopterin aldolase | len: 115 aa | Weakly similar to two uncharacterized proteins e.g. AAP95859 Dihydroneopterin aldolase (123 aa) from Haemophilus ducreyi, fasta scores: E(): 6.4e-08, 28.947% identity in 114 aa overlap | Contains Pfam match to entry PF02152 FolB, Dihydroneopterin aldolase; hypothetical protein	712679..713026	Ehrlichia ruminantium str. Welgevonden	3233453
YP_180274.1	CDS	mdh	NC_005295.2	713106	714050	D	Catalyzes the reversible oxidation of malate to oxaloacetate; malate dehydrogenase	713106..714050	Ehrlichia ruminantium str. Welgevonden	3233406
YP_180275.1	CDS	rpiB	NC_005295.2	716214	716654	D	rpiB | ribose 5-phosphate isomerase B | len: 146 aa | Similar to many e.g. RPIB_ECOLI P37351 Ribose 5-phosphate isomerase B (149 aa) from Escherichia coli, fasta scores: E(): 8.8e-19, 40.845% identity in 142 aa overlap | Contains Pfam match to entry PF02502 LacAB_rpiB, Ribose/Galactose Isomerase | Contains PS00237 G-protein coupled receptors signature; ribose-5-phosphate isomerase	716214..716654	Ehrlichia ruminantium str. Welgevonden	3232661
YP_180276.1	CDS	ubiG	NC_005295.2	716651	717376	D	Involved in ubiquinone biosynthesis; 3-demethylubiquinone-9 3-methyltransferase	716651..717376	Ehrlichia ruminantium str. Welgevonden	3232621
YP_180277.1	CDS	Erum4120	NC_005295.2	718128	718598	R	conserved hypothetical protein | len: 156 aa | Almost identical to the N-terminus of Q93ET1 Hypothetical iron-sulfur cofactor synthesis protein 1 (522 aa) from Ehrlichia ruminantium (Highway), fasta scores: E(): 2.6e-54, 97.351% identity in 151 aa overlap. Similar to many e.g. YFHP_ECOLI P77484 Hypothetical protein yfhP (162 aa) from Escherichia coli, fasta scores: E(): 5.1e-14, 35.252% identity in 139 aa overlap | Contains Pfam match to entry PF02082 Rrf2, Transcriptional regulator | Contains PS01332 Uncharacterized protein family UPF0074 signature | Almost identical to the N-terminus of Erum4140; hypothetical protein	complement(718128..718598)	Ehrlichia ruminantium str. Welgevonden	3233025
YP_180278.1	CDS	Erum4130	NC_005295.2	718955	719677	R	conserved hypothetical protein | len: 240 aa | Similar to many e.g. Q92HQ8 Hypothetical protein RC0713 (239 aa) from Rickettsia conorii, fasta scores: E(): 3.5e-50, 54.976% identity in 211 aa overlap | Contains PS00228 Tubulin-beta mRNA autoregulation signal; hypothetical protein	complement(718955..719677)	Ehrlichia ruminantium str. Welgevonden	3233026
YP_180279.1	CDS	Erum4140	NC_005295.2	720000	721568	D	unknown | len: 522 aa | Almost identical to Q93ET1 Hypothetical iron-sulfur cofactor synthesis protein 1 (522 aa) from Ehrlichia ruminantium (Highway), fasta scores: E(): 3.9e-191, 98.467% identity in 522 aa overlap. C-terminus is similar to many e.g. ISCS_ECOLI P39171 Cysteine desulfurase (404 aa) from Escherichia coli, fasta scores: E(): 3.4e-22, 34.054% identity in 370 aa overlap | Contains Pfam match to entry PF02082 Rrf2, Transcriptional regulator and PF00266 aminotran_5, Aminotransferase class-V | Contains PS01332 Uncharacterized protein family UPF0074 signature and PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site | The N-terminus is almost identical to Erum4120. The C-terminus is similar to Erum4150.; cysteine desulfurase	720000..721568	Ehrlichia ruminantium str. Welgevonden	3233027
YP_180280.1	CDS	iscS	NC_005295.2	721640	722881	D	catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis; cysteine desulfurase	721640..722881	Ehrlichia ruminantium str. Welgevonden	3233372
YP_180281.1	CDS	Erum4160	NC_005295.2	722916	723329	D	probable NifU-like protein | len: 137 aa | Almost identical to Q93ES9 NIFU-like protein (137 aa) from Ehrlichia ruminantium (Highway), fasta scores: E(): 1.8e-50, 99.270% identity in 137 aa overlap. Similar to many e.g. NIFU_ECOLI P77310 NifU-like protein (128 aa) from Escherichia coli, fasta scores: E(): 2.6e-36, 65.625% identity in 128 aa overlap | Contains Pfam match to entry PF01592 NifU_N, NifU-like N terminal domain; scaffold protein	722916..723329	Ehrlichia ruminantium str. Welgevonden	3233028
YP_180282.1	CDS	Erum4170	NC_005295.2	723342	723791	D	conserved hypothetical protein | len: 149 aa | Similar to many e.g. YFHF_ECOLI P36539 Protein yfhF (107 aa) from Escherichia coli, fasta scores: E(): 4.1e-09, 30.000% identity in 110 aa overlap | Contains Pfam match to entry PF01521 HesB-like, HesB-like domain | Contains PS01152 Hypothetical hesB/yadR/yfhF family signature; hypothetical protein	723342..723791	Ehrlichia ruminantium str. Welgevonden	3233029
YP_180283.1	CDS	hscB	NC_005295.2	723784	724221	D	possible hscB | possible co-chaperone protein HscB | len: 145 aa | Weakly similar to several uncharacterized proteins e.g. HSCB_RICCN Q92J06 Co-chaperone protein HscB homolog (166 aa) from Rickettsia conorii, fasta scores: E(): 1.4e-06, 32.704% identity in 159 aa overlap | Contains Pfam match to entry PF00226 DnaJ, DnaJ domain | Contains PS00284 Serpins signature; Co-chaperone protein hscB (Hsc20)	723784..724221	Ehrlichia ruminantium str. Welgevonden	3233458
YP_180284.1	CDS	hscA	NC_005295.2	724221	726071	D	hscA | chaperone protein HscA | len: 616 aa | Highly similar to many e.g. HSCA_ECOLI P36541 Chaperone protein hscA (Hsc66) (616 aa) from Escherichia coli, fasta scores: E(): 2.2e-67, 41.308% identity in 627 aa overlap | Contains Pfam match to entry PF00012 HSP70, Hsp70 protein | Contains PS00297 Heat shock hsp70 proteins family signature 1, PS00329 Heat shock hsp70 proteins family signature 2 and PS01036 Heat shock hsp70 proteins family signature 3; chaperone protein hscA-like protein	724221..726071	Ehrlichia ruminantium str. Welgevonden	3233364
YP_180285.1	CDS	fdxB	NC_005295.2	726100	726468	D	fdxB | ferredoxin, 2FE-2S | len: 122 aa | Similar to many e.g. FER_ECOLI P25528 Ferredoxin, 2Fe-2S (110 aa) from Escherichia coli, fasta scores: E(): 4.9e-10, 44.554% identity in 101 aa overlap | Contains Pfam match to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domain | Contains PS00814 Adrenodoxin family, iron-sulfur binding region signature and PS00190 Cytochrome c family heme-binding site signature; (2Fe-2S) ferredoxin	726100..726468	Ehrlichia ruminantium str. Welgevonden	3233321
YP_180286.1	CDS	Erum4210	NC_005295.2	726465	727535	D	probable membrane protein | len: 356 aa | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 7-29. The transmembrane helix could represent a possible N-terminal signal sequence.; hypothetical protein	726465..727535	Ehrlichia ruminantium str. Welgevonden	3233030
YP_180287.1	CDS	Erum4211	NC_005295.2	727561	727938	D	possible cytochrome c-type biogenesis protein | len: 125 aa | Similar to many e.g. CCMH_RHIME Cytochrome c-type biogenesis protein cycL precursor (151 aa) from Rhizobium meliloti, fasta scores: E(): 3.1e-09, 30.189% identity in 106 aa overlap | Contains Pfam match to entry PF03918 CcmH, Cytochrome C biogenesis protein | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 96-118; cytochrome c-type biogenesis protein cycL	727561..727938	Ehrlichia ruminantium str. Welgevonden	3233031
YP_180288.1	CDS	lysK	NC_005295.2	728815	730353	D	class I; LysRS1; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri this enzyme charges both tRNA molecules for lysine that exist in this organism (but the tRNALysUUU very poorly) and in the presence of LysRS2 can charge tRNAPyl with lysine; lysyl-tRNA synthetase	728815..730353	Ehrlichia ruminantium str. Welgevonden	3233386
YP_180289.1	CDS	Erum4230	NC_005295.2	731206	731613	D	probable integral membrane protein | len: 135 aa | Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site | Contains 2 probable transmembrane helices predicted by TMHMM2.0 at aa 5-27 and 47-69; hypothetical protein	731206..731613	Ehrlichia ruminantium str. Welgevonden	3233032
YP_180290.1	CDS	truA	NC_005295.2	732895	733635	R	mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A	complement(732895..733635)	Ehrlichia ruminantium str. Welgevonden	3232785
YP_180291.1	CDS	pyrB	NC_005295.2	734164	735084	R	catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase	complement(734164..735084)	Ehrlichia ruminantium str. Welgevonden	3232639
YP_180292.1	CDS	gyrB	NC_005295.2	735447	737843	D	gyrB | DNA gyrase subunit B | len: 798 aa | Highly similar to many e.g. GYRB_CAUCR P48197 DNA gyrase subunit B (805 aa) from Caulobacter crescentus, fasta scores: E(): 2.2e-154, 51.797% identity in 807 aa overlap | Contains Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, PF00204 DNA_gyraseB, DNA gyrase B, PF01751 Toprim, Toprim domain and PF00986 DNA_gyraseB_C, DNA gyrase B subunit, carboxyl terminus | Contains PS00177 DNA topoisomerase II signature | C-terminal region is almost identical to Erum4431; DNA gyrase subunit B	735447..737843	Ehrlichia ruminantium str. Welgevonden	3233356
YP_180293.1	CDS	Erum4261	NC_005295.2	737973	738227	D	unknown | len: 84 aa; hypothetical protein	737973..738227	Ehrlichia ruminantium str. Welgevonden	3233033
YP_180294.1	CDS	nuoG	NC_005295.2	738237	740291	D	Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit G	738237..740291	Ehrlichia ruminantium str. Welgevonden	3233421
YP_180295.1	CDS	nuoH	NC_005295.2	740298	741401	D	Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit H	740298..741401	Ehrlichia ruminantium str. Welgevonden	3233422
YP_180296.1	CDS	gltX	NC_005295.2	742506	743918	R	Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase	complement(742506..743918)	Ehrlichia ruminantium str. Welgevonden	3233341
YP_180297.1	CDS	Erum4320	NC_005295.2	744213	745490	R	unknown | len: 425 aa; hypothetical protein	complement(744213..745490)	Ehrlichia ruminantium str. Welgevonden	3233036
YP_180298.1	CDS	mutM	NC_005295.2	745913	746722	D	mutM | formamidopyrimidine-DNA glycosylase | len: 269 aa | Similar to many e.g. FPG_ECOLI Formamidopyrimidine-DNA glycosylaase (269 aa) from Escherichia coli, fasta scores: E(): 9.9e-36, 36.667% identity in 270 aa overlap | Contains Pfam match to entry PF01149 Fapy_DNA_glyco, Formamidopyrimidine-DNA glycosylase; formamidopyrimidine-DNA glycosidase	745913..746722	Ehrlichia ruminantium str. Welgevonden	3233411
YP_180299.1	CDS	Erum4340	NC_005295.2	746784	747962	D	unknown | len: 392 aa; hypothetical protein	746784..747962	Ehrlichia ruminantium str. Welgevonden	3233037
YP_180300.1	CDS	Erum4350	NC_005295.2	748030	749259	R	unknown | len: 409 aa | Similar to the N-terminus of several uncharacterized proteins e.g. Q9ZCZ1 Probable 3-hydroxyacyl-CoA dehydrogenase (720 aa) from Rickettsia prowazekii, fasta scores: E(): 1.5e-26, 30.657% identity in 411 aa overlap; 3-hydroxyacyl-CoA dehydrogenase	complement(748030..749259)	Ehrlichia ruminantium str. Welgevonden	3233038
YP_180301.1	CDS	Erum4360	NC_005295.2	749327	749800	R	unknown | len: 157 aa; hypothetical protein	complement(749327..749800)	Ehrlichia ruminantium str. Welgevonden	3233039
YP_180302.1	CDS	miaA	NC_005295.2	749915	750817	D	probable miaA | probable tRNA delta(2)-isopentenylpyrophoshate transferase | len: 300 aa | Similar to many e.g. MIAA_ECOLI P16384 tRNA delta(2)-isopentenylpyrophosphate transferase (316 aa) from Escherichia coli, fasta scores: E(): 6.3e-17, 27.240% identity in 279 aa overlap | Contains Pfam match to entry PF01715 IPPT, IPP transferase | Contains PS00017 ATP/GTP-binding site motif A (P-loop); tRNA delta(2)-isopentenylpyrophosphate transferase	749915..750817	Ehrlichia ruminantium str. Welgevonden	3233527
YP_180303.1	CDS	Erum4390	NC_005295.2	752650	753372	R	unknown | len: 240 aa | Similar to Erum4400; hypothetical protein	complement(752650..753372)	Ehrlichia ruminantium str. Welgevonden	3233041
YP_180304.1	CDS	Erum4400	NC_005295.2	753876	756860	D	unknown | len: 994 aa | Similar to Erum4390; hypothetical protein	753876..756860	Ehrlichia ruminantium str. Welgevonden	3233042
YP_180305.1	CDS	Erum4410	NC_005295.2	757200	757898	D	possible type IV secretion system protein | len: 232 aa | Similar to several e.g. Q8RPL7 VirB8 (234 aa) from Anaplasma phagocytophilum, fasta scores: E(): 5.9e-05, 23.832% identity in 214 aa overlap | Contains Pfam match to entry PF04335 VirB8, VirB8 protein | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 40-62; VirB8 protein	757200..757898	Ehrlichia ruminantium str. Welgevonden	3233043
YP_180306.1	CDS	nuoD	NC_005295.2	759601	760782	D	Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit D	759601..760782	Ehrlichia ruminantium str. Welgevonden	3233418
YP_180307.1	CDS	nuoE	NC_005295.2	760786	761337	D	Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit E	760786..761337	Ehrlichia ruminantium str. Welgevonden	3233419
YP_180308.1	CDS	Erum4440	NC_005295.2	762952	763539	D	probable integral membrane protein | len: 195 aa | Contains 4 probable transmembrane helices predicted by TMHMM2.0 at aa 12-34, 38-55, 96-115 and 125-144. The initial transmembrane helix could represent a possible N-terminal signal sequence.; hypothetical protein	762952..763539	Ehrlichia ruminantium str. Welgevonden	3233045
YP_180309.1	CDS	Erum4450	NC_005295.2	764331	765173	D	unknown | len: 280 aa; hypothetical protein	764331..765173	Ehrlichia ruminantium str. Welgevonden	3233046
YP_180310.1	CDS	pccB	NC_005295.2	765995	767527	D	pccB | propionyl-CoA carboxylase beta chain | len: 510 aa | Highly similar to many e.g. PCCB_SACER P53003 Propionyl-CoA carboxylase beta chain (546 aa) from Saccharopolyspora erythraea, fasta scores: E(): 4e-93, 52.874% identity in 522 aa overlap | Contains Pfam match to entry PF01039 Carboxyl_trans, Carboxyl transferase domain | A central region is almost identical to Erum4471; human propionyl-CoA carboxylase beta chain, mitochondrial precursor	765995..767527	Ehrlichia ruminantium str. Welgevonden	3233432
YP_180311.1	CDS	Erum4470	NC_005295.2	768697	769854	R	probable exported protein | len: 385 aa | Weakly similar to two other rickettsial proteins e.g. Q92JG9 Hypothetical protein RC0098 (438 aa) from Rickettsia conorii, fasta scores: E(): 1.6e-06, 22.472% identity in 356 aa overlap | Contains PS00225 Crystallins beta and gamma 'Greek key' motif signature | Contains signal peptide predicted by SignalP 2.0 HMM (probability 1.000), cleavage site probability 0.999 between residues 24 and 25 | Similar to Erum5000; hypothetical protein	complement(768697..769854)	Ehrlichia ruminantium str. Welgevonden	3233047
YP_180312.1	CDS	argB	NC_005295.2	771427	772344	R	catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase	complement(771427..772344)	Ehrlichia ruminantium str. Welgevonden	3233271
YP_180313.1	CDS	engB	NC_005295.2	772367	772969	R	binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC	complement(772367..772969)	Ehrlichia ruminantium str. Welgevonden	3233498
YP_180314.1	CDS	prfA	NC_005295.2	773130	774209	D	recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1	773130..774209	Ehrlichia ruminantium str. Welgevonden	3233468
YP_180315.1	CDS	Erum4510	NC_005295.2	775229	776437	D	probable sodium:dicarboxylate symporter (glutamate) | len: 402 aa | Highly similar to many uncharacterized proteins e.g. Q9PKG4 Sodium:dicarboxylate symporter family protein (415 aa) from Chlamydia muridarum, fasta scores: E(): 1.6e-61, 45.501% identity in 389 aa overlap. Similar to many e.g. GLTP_ECOLI P21345 Proton glutamate symport protein (437 aa) from Escherichia coli, fasta scores: E(): 4.4e-18, 22.304% identity in 408 aa overlap | Contains Pfam match to entry PF00375 SDF, Sodium:dicarboxylate symporter family | Contains 8 probable transmembrane helices predicted by TMHMM2.0 at aa 5-27, 37-54, 74-96, 135-157, 178-200, 215-237, 287-309 and 324-346; proton/sodium-glutamate symport protein	775229..776437	Ehrlichia ruminantium str. Welgevonden	3233049
YP_180316.1	CDS	rmuC	NC_005295.2	777283	778593	R	rmuC | DNA recombination protein RmuC | len: 436 aa | Similar to many e.g. RMUC_ECOLI DNA recombination protein rmuC (475 aa) from Escherichia coli, fasta scores: E(): 1e-45, 35.659% identity in 387 aa overlap | Contains Pfam match to entry PF02646 RmuC, RmuC family | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 2-23; DNA recombination protein rmuC-like protein	complement(777283..778593)	Ehrlichia ruminantium str. Welgevonden	3232655
YP_180317.1	CDS	Erum4530	NC_005295.2	778805	779404	D	unknown | len: 199 aa | Contains a tandem repeat, 22 bp repeated 2.0 times; hypothetical protein	778805..779404	Ehrlichia ruminantium str. Welgevonden	3233050
YP_180318.1	CDS	serS	NC_005295.2	779622	780905	D	catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase	779622..780905	Ehrlichia ruminantium str. Welgevonden	3232725
YP_180319.1	CDS	hemF	NC_005295.2	783039	783905	R	catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis; coproporphyrinogen III oxidase	complement(783039..783905)	Ehrlichia ruminantium str. Welgevonden	3233361
YP_180320.1	CDS	Erum4560	NC_005295.2	784172	784459	R	conserved hypothetical protein | len: 95 aa | Similar to several from Alphaproteobacteria e.g. Y113_METEX O05113 Hypothetical 9.7 kDa protein (88 aa) from Methylobacterium extorquens, fasta scores: E(): 3.4e-08, 44.872% identity in 78 aa overlap; hypothetical protein	complement(784172..784459)	Ehrlichia ruminantium str. Welgevonden	3233051
YP_180321.1	CDS	tal	NC_005295.2	784766	785428	R	similar to novel fructose-6-phosphate aldolase from Escherichia coli; enzyme from Methanocaldococcus janaschii shows transaldolase activity; translaldolase	complement(784766..785428)	Ehrlichia ruminantium str. Welgevonden	3232608
YP_180322.1	CDS	atpC	NC_005295.2	785412	785816	R	possible atpC | possible ATP synthase epsilon chain | len: 134 aa | Weakly similar to several uncharacterized proteins e.g. ATPE_STRPN Q97PT7 ATP synthase epsilon chain (139 aa) from Streptococcus pneumoniae, fasta scores: E(): 0.0081, 28.205% identity in 117 aa overlap | Contains Pfam match to entry PF02823 ATP-synt_DE_N, ATP synthase, Delta/Epsilon chain, beta-sandwich domain; ATP synthase epsilon chain 2	complement(785412..785816)	Ehrlichia ruminantium str. Welgevonden	3233447
YP_180323.1	CDS	atpD	NC_005295.2	785819	787333	R	Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; ATP synthase F0F1 subunit beta	complement(785819..787333)	Ehrlichia ruminantium str. Welgevonden	3233284
YP_180324.1	CDS	Erum4600	NC_005295.2	787775	789145	D	probable magnesium transporter | len: 456 aa | Similar to many uncharacterized proteins e.g. Q9ZCX0 Magnesium transporter (456 aa) from Rickettsia prowazekii, fasta scores: E(): 3.5e-49, 34.298% identity in 449 aa overlap | Contains Pfam match to entry PF03448 MgtE_N, MgtE intracellular domain, 2 matches to entry PF00571 CBS, CBS domain and PF01769 MgtE, Divalent cation transporter | Contains 4 probable transmembrane helices predicted by TMHMM2.0 at aa 295-317, 367-386, 401-423 and 432-454; magnesium transporter	787775..789145	Ehrlichia ruminantium str. Welgevonden	3233052
YP_180325.1	CDS	Erum4610	NC_005295.2	790233	790607	D	probable membrane protein | len: 124 aa | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 10-30. The transmembrane helix could represent a possible N-terminal signal sequence.; hypothetical protein	790233..790607	Ehrlichia ruminantium str. Welgevonden	3233053
YP_180326.1	CDS	Erum4620	NC_005295.2	791190	791594	D	probable membrane protein | len: 134 aa | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 10-32. The transmembrane helix could represent a possible N-terminal signal sequence.; hypothetical protein	791190..791594	Ehrlichia ruminantium str. Welgevonden	3233054
YP_180327.1	CDS	Erum4630	NC_005295.2	792192	792569	D	probable membrane protein | len: 125 aa | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 10-32. The transmembrane helix could represent a possible N-terminal signal sequence.; hypothetical protein	792192..792569	Ehrlichia ruminantium str. Welgevonden	3233055
YP_180328.1	CDS	Erum4640	NC_005295.2	793044	793415	D	probable membrane protein | len: 123 aa | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 15-37; hypothetical protein	793044..793415	Ehrlichia ruminantium str. Welgevonden	3233056
YP_180329.1	CDS	Erum4650	NC_005295.2	793790	796105	R	unknown | len: 771 aa; hypothetical protein	complement(793790..796105)	Ehrlichia ruminantium str. Welgevonden	3233057
YP_180330.1	CDS	clpA	NC_005295.2	796437	798731	R	clpA | ATP-dependent Clp protease, ATP-binding subunit | len: 764 aa | Highly similar to many e.g. CLPA_ECOLI ATP-dependent Clp protease ATP-binding subunit clpA (758 aa) from Escherichia coli, fasta scores: E(): 5.6e-117, 47.320% identity in 765 aa overlap | Contains Pfam match to entry PF02861 Clp_N, Clp amino terminal domain and 2 matches to entry PF00004 AAA, ATPase family associated with various cellular activities (AAA) | Contains 2 PS00017 ATP/GTP-binding site motif A (P-loop) and PS00870 Chaperonins clpA/B signature 1 | Similar to Erum6400; ATP-dependent Clp protease ATP-binding subunit ClpA	complement(796437..798731)	Ehrlichia ruminantium str. Welgevonden	3233295
YP_180331.1	CDS	Erum4670	NC_005295.2	798898	799605	D	conserved hypothetical integral membrane protein | len: 235 aa | Almost identical to Q93FR3 Hypothetical transmembrane protein (235 aa) from Ehrlichia ruminantium (Highway), fasta scores: E(): 7.2e-81, 97.021% identity in 235 aa overlap. Similar to many hypothetical proteins e.g. YGDQ_ECOLI Hypothetical protein ygdQ (237 aa) from Escherichia coli, fasta scores: E(): 2.8e-25, 34.978% identity in 223 aa overlap | Contains Pfam match to entry PF03741 TerC, Integral membrane protein TerC family | Contains 7 probable transmembrane helices predicted by TMHMM2.0 at aa 10-32, 45-67, 77-99, 120-142, 146-168, 181-203 and 209-226; hypothetical protein	798898..799605	Ehrlichia ruminantium str. Welgevonden	3233058
YP_180332.1	CDS	rbfA	NC_005295.2	800773	801120	R	probable rbfA | probable ribosome-binding factor A | len: 115 aa | Identical to Q93FR2 Hypothetical ribosome-binding factor A (115 aa) from Ehrlichia ruminantium (Highway), fasta scores: E(): 1.2e-40, 100.000% identity in 115 aa overlap. Weakly similar to many e.g. RBFA_ECOLI P09170 Ribosome-binding factor A (132 aa) from Escherichia coli, fasta scores: E(): 0.067, 29.730% identity in 111 aa overlap | Contains Pfam match to entry PF02033 RBFA, Ribosome-binding factor A | Contains PS01319 Ribosome-binding factor A signature; ribosome-binding factor A	complement(800773..801120)	Ehrlichia ruminantium str. Welgevonden	3232588
YP_180333.1	CDS	infB	NC_005295.2	801117	803687	R	Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2	complement(801117..803687)	Ehrlichia ruminantium str. Welgevonden	3233370
YP_180334.1	CDS	nusA	NC_005295.2	803711	805264	R	modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA	complement(803711..805264)	Ehrlichia ruminantium str. Welgevonden	3232574
YP_180335.1	CDS	Erum4710	NC_005295.2	805402	808521	R	probable integral membrane transport protein | len: 1039 aa | Similar to many uncharacterized proteins e.g. YEGO_ECOLI P76399 Hypothetical protein yegO (1025 aa) from Escherichia coli, fasta scores: E(): 8.4e-43, 22.062% identity in 1038 aa overlap | Contains Pfam match to entry PF00873 ACR_tran, AcrB/AcrD/AcrF family | Contains 12 probable transmembrane helices predicted by TMHMM2.0 at aa 12-34, 335-352, 359-381, 385-407, 428-450, 460-482, 532-554, 861-880, 887-909, 914-936, 957-979 and 1003-1025; aminoglycoside efflux pump (acriflavine resistance protein D)	complement(805402..808521)	Ehrlichia ruminantium str. Welgevonden	3233059
YP_180336.1	CDS	tatC	NC_005295.2	808620	809372	R	tatC | Sec-independent protein translocase protein TatC | len: 250 aa | Similar to many e.g. TATC_ECOLI Sec-independent protein translocase protein tatC (258 aa) from Escherichia coli, fasta scores: E(): 2.7e-28, 35.537% identity in 242 aa overlap | Contains Pfam match to entry PF00902 TatC, Sec-independent protein translocase protein (TatC) | Contains 5 probable transmembrane helices predicted by TMHMM2.0 at aa 21-40, 77-99, 111-133, 171-193 and 206-228; SEC-independent protein translocase protein TatC	complement(808620..809372)	Ehrlichia ruminantium str. Welgevonden	3232735
YP_180337.1	CDS	ispG	NC_005295.2	809400	810668	R	catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase	complement(809400..810668)	Ehrlichia ruminantium str. Welgevonden	3233520
YP_180338.1	CDS	Erum4740	NC_005295.2	811538	813457	R	probable exported protein | len: 639 aa | Weakly similar to several eukaryotic proteins e.g. Q8HZW3 Heavy neurofilament protein (1135 aa) from Canis familiaris, fasta scores: E(): 1.8e-09, 34.971% identity in 509 aa overlap | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.652) with cleavage site probability 0.304 between residues 25 and 26 | Contains a tandem repeat, 138 bp repeated 6.9 times; hypothetical protein	complement(811538..813457)	Ehrlichia ruminantium str. Welgevonden	3233060
YP_180339.1	CDS	dxr	NC_005295.2	813717	814880	R	catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase	complement(813717..814880)	Ehrlichia ruminantium str. Welgevonden	3233313
YP_180340.1	CDS	nuoN	NC_005295.2	814931	816355	R	nuoN | NADH-quinone oxidoreductase chain N | len: 474 aa | Highly similar to many e.g. NQOE_PARDE P29926 NADH-quinone oxidoreductase chain 14 (499 aa) from Paracoccus denitrificans, fasta scores: E(): 4e-52, 35.897% identity in 429 aa overlap and NUON_RHOCA P50973 NADH-quinone oxidoreductase chain N (478 aa) from Rhodobacter capsulatus, fasta scores: E(): 7.9e-51, 35.550% identity in 436 aa overlap | Contains Pfam match to entry PF00361 oxidored_q1, NADH-Ubiquinone/plastoquinone (complex I), various chains | Contains 13 probable transmembrane helices predicted by TMHMM2.0 at aa 7-29, 33-55, 68-90, 100-122, 151-173, 193-215, 228-250, 265-284, 291-310, 315-337, 357-379, 394-416 and 437-459 | Similar to Erum1240, Erum6700, Erum4780, Erum4770, Erum5440; NADH-ubiquinone oxidoreductase chain N	complement(814931..816355)	Ehrlichia ruminantium str. Welgevonden	3233428
YP_180341.1	CDS	nuoM	NC_005295.2	816363	817823	R	nuoM | NADH-quinone oxidoreductase chain M | len: 486 aa | Highly similar to many e.g. NQOD_PARDE P29925 NADH-quinone oxidoreductase chain 13 (513 aa) from Paracoccus denitrificans, fasta scores: E(): 2.8e-72, 44.283% identity in 481 aa overlap and NUOM_RHOCA P50974 NADH-quinone oxidoreductase chain M (512 aa) from Rhodobacter capsulatus, fasta scores: E(): 1.5e-54, 43.064% identity in 483 aa overlap | Contains Pfam match to entry PF00361 oxidored_q1, NADH-Ubiquinone/plastoquinone (complex I), various chains | Contains 14 probable transmembrane helices predicted by TMHMM2.0 at aa 4-21, 26-48, 73-95, 102-121, 125-147, 158-180, 204-226, 233-252, 267-289, 296-313, 323-345, 366-388, 403-422 and 443-465 | Similar to Erum1240, Erum6700, Erum4780, Erum4760, Erum5440; NADH-quinone oxidoreductase chain M	complement(816363..817823)	Ehrlichia ruminantium str. Welgevonden	3233427
YP_180342.1	CDS	nuoL	NC_005295.2	817830	819698	R	nuoL | NADH-quinone oxidoreductase chain L | len: 622 aa | Highly similar to many e.g. NQOC_PARDE P29924 NADH-quinone oxidoreductase chain 12 (703 aa) from Paracoccus denitrificans, fasta scores: E(): 1.2e-82, 41.512% identity in 701 aa overlap and NUOL_RHOCA P50939 NADH-quinone oxidoreductase chain L (712 aa) from Rhodobacter capsulatus, fasta scores: E(): 1.3e-74, 41.749% identity in 709 aa overlap | Contains Pfam match to entry PF00662 oxidored_q1_N, NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus and PF00361 oxidored_q1 NADH-Ubiquinone/plastoquinone (complex I), various chains | Contains 16 probable transmembrane helices predicted by TMHMM2.0 at aa 26-48, 78-100, 107-126, 130-152, 164-186, 206-228, 249-271, 281-303, 310-332, 337-356, 376-398, 413-435, 455-472, 502-524, 545-565 and 596-618 | Contains predicted helix-turn-helix motif | Similar to Erum1240, Erum4770, Erum4760, Erum6700; NADH-quinone oxidoreductase chain L	complement(817830..819698)	Ehrlichia ruminantium str. Welgevonden	3233426
YP_180343.1	CDS	nuoK	NC_005295.2	819772	820098	R	nuoK | NADH-quinone oxidoreductase chain K | len: 108 aa | Highly similar to many e.g. NQOB_PARDE P29923 NADH-quinone oxidoreductase chain 11 (101 aa) from Paracoccus denitrificans, fasta scores: E(): 2.7e-23, 65.657% identity in 99 aa overlap and NUOK_RHOCA P50940 NADH-quinone oxidoreductase chain K (102 aa) from Rhodobacter capsulatus, fasta scores: E(): 6e-23, 65.657% identity in 99 aa overlap | Contains Pfam match to entry PF00420 oxidored_q2, NADH-ubiquinone/plastoquinone oxidoreductase chain 4L | Contains 3 probable transmembrane helices predicted by TMHMM2.0 at aa 10-32, 39-61 and 71-93; NADH-quinone oxidoreductase chain K	complement(819772..820098)	Ehrlichia ruminantium str. Welgevonden	3233425
YP_180344.1	CDS	nuoJ	NC_005295.2	820082	820684	R	nuoJ | NADH-quinone oxidoreductase chain J | len: 200 aa | Similar to many e.g. NUOJ_RHOCA P50975 NADH-quinone oxidoreductase chain J (202 aa) from Rhodobacter capsulatus, fasta scores: E(): 2.8e-23, 39.899% identity in 198 aa overlap and NQOA_PARDE P29922 NADH-quinone oxidoreductase chain 10 (200 aa) from Paracoccus denitrificans, fasta scores: E(): 1.5e-21, 37.688% identity in 199 aa overlap | Contains Pfam match to entry PF00499 oxidored_q3, NADH-ubiquinone/plastoquinone oxidoreductase chain 6 | Contains 5 probable transmembrane helices predicted by TMHMM2.0 at aa 4-23, 30-47, 51-73, 86-108 and 139-161; NADH-quinone oxidoreductase chain J	complement(820082..820684)	Ehrlichia ruminantium str. Welgevonden	3233424
YP_180345.1	CDS	nuoF	NC_005295.2	821677	822954	R	part of NADH-ubiquinone oxidoreductase complex I; shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase; NADH dehydrogenase I subunit F	complement(821677..822954)	Ehrlichia ruminantium str. Welgevonden	3233420
YP_180346.1	CDS	rpmA	NC_005295.2	823195	823461	R	involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27	complement(823195..823461)	Ehrlichia ruminantium str. Welgevonden	3232684
YP_180347.1	CDS	rplU	NC_005295.2	823467	823775	R	rplU | 50S ribosomal protein L21 | len: 102 aa | Similar to many e.g. RL21_ECOLI P02422 50S ribosomal protein L21 (103 aa) from Escherichia coli, fasta scores: E(): 3.4e-10, 38.235% identity in 102 aa overlap | Contains Pfam match to entry PF00829 Ribosomal_L21p, Ribosomal prokaryotic L21 protein | Contains PS01169 Ribosomal protein L21 signature; 50S ribosomal protein L21	complement(823467..823775)	Ehrlichia ruminantium str. Welgevonden	3232680
YP_180348.1	CDS	eno	NC_005295.2	823941	825206	D	enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase	823941..825206	Ehrlichia ruminantium str. Welgevonden	3233314
YP_180349.1	CDS	obgE	NC_005295.2	825203	826225	D	essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE	825203..826225	Ehrlichia ruminantium str. Welgevonden	3233061
YP_180350.1	CDS	mraW	NC_005295.2	828019	828924	R	probable mraW | probable S-adenosyl-methyltransferase MraW | len: 301 aa | Similar to many e.g. MRAW_ECOLI P18595 S-adenosyl-methyltransferase mraW (313 aa) from Escherichia coli, fasta scores: E(): 4.6e-35, 41.176% identity in 306 aa overlap | Contains Pfam match to entry PF01795 Methyltransf_5, MraW methylase family; S-adenosyl-methyltransferase MraW	complement(828019..828924)	Ehrlichia ruminantium str. Welgevonden	3233528
YP_180351.1	CDS	ileS	NC_005295.2	830618	833932	R	IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 2 subfamily; some organisms carry two different copies of this enzyme; in some organisms, the type 2 subfamily is associated with resistance to the antibiotic pseudomonic acid (mupirocin); isoleucyl-tRNA synthetase	complement(830618..833932)	Ehrlichia ruminantium str. Welgevonden	3233369
YP_180352.1	CDS	Erum4880	NC_005295.2	834070	834513	D	possible bacterioferritin comigratory protein | len: 147 aa | Similar to many e.g. BCP_ECOLI P23480 Bacterioferritin comigratory protein (156 aa) from Escherichia coli, fasta scores: E(): 3.4e-14, 34.228% identity in 149 aa overlap | Contains Pfam match to entry PF00578 AhpC-TSA, AhpC/TSA family | Similar to Erum3480; bacterioferritin comigratory protein	834070..834513	Ehrlichia ruminantium str. Welgevonden	3233062
YP_180353.1	CDS	Erum4890	NC_005295.2	834524	835240	D	in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE	834524..835240	Ehrlichia ruminantium str. Welgevonden	3233063
YP_180354.1	CDS	Erum4900	NC_005295.2	835243	835764	D	unknown | len: 173 aa | Weakly similar to many e.g. YGFA_ECOLI P09160 Hypothetical protein ygfA (182 aa) from Escherichia coli, fasta scores: E(): 1.5e-05, 29.189% identity in 185 aa overlap | Contains Pfam match to entry PF01812 5-FTHF_cyc-lig, 5-formyltetrahydrofolate cyclo-ligase family; hypothetical protein	835243..835764	Ehrlichia ruminantium str. Welgevonden	3233064
YP_180355.1	CDS	argS	NC_005295.2	835882	837612	R	catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase	complement(835882..837612)	Ehrlichia ruminantium str. Welgevonden	3233278
YP_180356.1	CDS	recO	NC_005295.2	837890	838624	D	involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO	837890..838624	Ehrlichia ruminantium str. Welgevonden	3233463
YP_180357.1	CDS	Erum4930	NC_005295.2	839544	840104	D	unknown | len: 186 aa; hypothetical protein	839544..840104	Ehrlichia ruminantium str. Welgevonden	3233065
YP_180358.1	CDS	Erum4950	NC_005295.2	842554	844032	D	possible competence protein | len: 492 aa | Highly similar to many e.g. COMM_HAEIN P45049 Competence protein comM (509 aa) from Haemophilus influenzae, fasta scores: E(): 4.3e-61, 41.935% identity in 496 aa overlap | Contains Pfam match to entry PF01078 Mg_chelatase, Magnesium chelatase, subunit ChlI | Contains PS00017 ATP/GTP-binding site motif A (P-loop); competence protein	842554..844032	Ehrlichia ruminantium str. Welgevonden	3233068
YP_180359.1	CDS	Erum4960	NC_005295.2	844120	844509	D	probable integral membrane protein | len: 129 aa | Contains 2 probable transmembrane helices predicted by TMHMM2.0 at aa 23-45 and 60-82; hypothetical protein	844120..844509	Ehrlichia ruminantium str. Welgevonden	3233069
YP_180360.1	CDS	rbn	NC_005295.2	845843	846676	R	possible rbn | possible tRNA processing ribonuclease BN | len: 277 aa | Similar to many uncharacterized proteins e.g. Q88EA6 Ribonuclease BN, (318 aa) from Pseudomonas putida, fasta scores: E(): 6.5e-11, 28.358% identity in 268 aa overlap. Weakly similar to RBN_ECOLI P32146 tRNA processing ribonuclease BN (290 aa) from Escherichia coli, fasta scores: E(): 0.00042, 23.077% identity in 247 aa overlap | Contains Pfam match to entry PF03631 Ribonuclease_BN, Ribonuclease BN-like family | Contains 5 probable transmembrane helices predicted by TMHMM2.0 at aa 29-51, 141-163, 175-197, 207-229 and 241-263; hypothetical protein	complement(845843..846676)	Ehrlichia ruminantium str. Welgevonden	3233462
YP_180361.1	CDS	thiL	NC_005295.2	846849	847799	D	probable thiL | probable thiamine-monophosphate kinase | len: 316 aa | Similar to many e.g. THIL_ECOLI P77785 Thiamine-monophosphate kinase (325 aa) from Escherichia coli, fasta scores: E(): 2.1e-31, 40.391% identity in 307 aa overlap | Contains Pfam match to entry PF02769 AIRS_C, AIR synthase related protein, C-terminal domain; thiamine-monophosphate kinase	846849..847799	Ehrlichia ruminantium str. Welgevonden	3232612
YP_180362.1	CDS	dnaQ	NC_005295.2	848673	849401	R	dnaQ | DNA polymerase III, epsilon subunit | len: 242 aa | Similar to many e.g. DP3E_ECOLI P03007 DNA polymerase III, epsilon chain (243 aa) from Escherichia coli, fasta scores: E(): 1.4e-27, 40.351% identity in 228 aa overlap | Contains Pfam match to entry PF00929 Exonuclease, Exonuclease; DNA polymerase III, epsilon chain	complement(848673..849401)	Ehrlichia ruminantium str. Welgevonden	3233312
YP_180363.1	CDS	Erum5000	NC_005295.2	849950	851422	R	probable exported protein | len: 490 aa | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.957) with cleavage site probability 0.943 between residues 27 and 28 | Similar to Erum5010, Erum4470; hypothetical protein	complement(849950..851422)	Ehrlichia ruminantium str. Welgevonden	3233070
YP_180364.1	CDS	Erum5010	NC_005295.2	851925	853619	R	probable exported protein | len: 564 aa | Weakly similar to Q9ZE78 Hypothetical protein RP068 (440 aa) from Rickettsia prowazekii, fasta scores: E(): 4.5e-06, 26.836% identity in 354 aa overlap | Contains PS00017 ATP/GTP-binding site motif A (P-loop) | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.993 between residues 23 and 24 | Contains a tandem repeat, 24 bp repeated 2.1 times | Similar to Erum5000; hypothetical protein	complement(851925..853619)	Ehrlichia ruminantium str. Welgevonden	3233071
YP_180365.1	CDS	petC	NC_005295.2	854272	855030	R	petC | cytochrome c1 precursor | len: 252 aa | Similar to many e.g. CY1_RHORU P23135 Cytochrome c1 precursor (272 aa) from Rhodospirillum rubrum, fasta scores: E(): 1.6e-26, 48.729% identity in 236 aa overlap | Contains Pfam match to entry PF02167 Cytochrome_C1, Cytochrome C1 family | Contains PS00190 Cytochrome c family heme-binding site signature | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.994 between residues 19 and 20 | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 222-241; cytochrome c1 precursor	complement(854272..855030)	Ehrlichia ruminantium str. Welgevonden	3233440
YP_180366.1	CDS	petB	NC_005295.2	855030	856256	R	petB | cytochrome b | len: 408 aa | Highly similar to many e.g. CYB_RHORU P23134 Cytochrome b (405 aa) from Rhodospirillum rubrum, fasta scores: E(): 9.1e-104, 61.125% identity in 391 aa overlap | Contains Pfam match to entry PF00033 cytochrome_b_N, Cytochrome b(N-terminal)/b6/petB and PF00032 cytochrome_b_C, Cytochrome b(C-terminal)/b6/petD | Contains PS00192 Cytochrome b/b6 heme-ligand signature and PS00193 Cytochrome b/b6 Qo site signature | Contains 9 probable transmembrane helices predicted by TMHMM2.0 at aa 44-66, 91-113, 128-150, 157-179, 194-216, 242-264, 306-325, 338-356 and 366-388 | Contains a tandem repeat, 20 bp repeated 2.0 times; cytochrome B	complement(855030..856256)	Ehrlichia ruminantium str. Welgevonden	3233439
YP_180367.1	CDS	petA	NC_005295.2	856280	856843	R	petA | ubiquinol-cytochrome c reductase iron-sulphur subunit | len: 187 aa | Similar to many e.g. UCRI_RHORU P23136 Ubiquinol-cytochrome C reductase iron-sulfur subunit (182 aa) from Rhodospirillum rubrum, fasta scores: E(): 7.6e-33, 49.112% identity in 169 aa overlap | Contains Pfam match to entry PF00355 Rieske, Rieske [2Fe-2S] domain | Contains PS00199 Rieske iron-sulfur protein signature 1 and PS00200 Rieske iron-sulfur protein signature 2 | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 20-41; ubiquinol-cytochrome C reductase iron-sulfur subunit	complement(856280..856843)	Ehrlichia ruminantium str. Welgevonden	3233438
YP_180368.1	CDS	Erum5050	NC_005295.2	857341	858213	R	probable integral membrane protein | len: 290 aa | Contains 5 probable transmembrane helices predicted by TMHMM2.0 at aa 10-32, 39-56, 71-90, 160-182 and 197-219; hypothetical protein	complement(857341..858213)	Ehrlichia ruminantium str. Welgevonden	3233072
YP_180369.1	CDS	Erum5060	NC_005295.2	858634	859434	R	probable ABC transporter, membrane-spanning protein | len: 266 aa | Similar to many e.g. ZNUB_ECOLI P39832 High-affinity zinc uptake system membrane protein ZnuB (261 aa) from Escherichia coli, fasta scores: E(): 1.3e-26, 33.065% identity in 248 aa overlap | Contains Pfam match to entry PF00950 ABC-3, ABC 3 transport family | Contains 7 probable transmembrane helices predicted by TMHMM2.0 at aa 9-31, 54-76, 89-111, 131-149, 177-199, 214-236 and 241-262; high-affinity zinc uptake system membrane protein znuB	complement(858634..859434)	Ehrlichia ruminantium str. Welgevonden	3233073
YP_180370.1	CDS	Erum5070	NC_005295.2	859441	859803	R	conserved hypothetical protein | len: 120 aa | Similar to several e.g. Q8UF39 Hypothetical protein Atu1561 (130 aa) from Agrobacterium tumefaciens, fasta scores: E(): 1.3e-08, 33.333% identity in 126 aa overlap | Contains Pfam match to entry PF04635 DUF598, Protein of unknown function, DUF598; hypothetical protein	complement(859441..859803)	Ehrlichia ruminantium str. Welgevonden	3233074
YP_180371.1	CDS	tsf	NC_005295.2	860209	861075	R	EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts	complement(860209..861075)	Ehrlichia ruminantium str. Welgevonden	3232788
YP_180372.1	CDS	rpsB	NC_005295.2	861065	861925	R	one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2	complement(861065..861925)	Ehrlichia ruminantium str. Welgevonden	3232699
YP_180373.1	CDS	maf	NC_005295.2	863542	864120	R	Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein	complement(863542..864120)	Ehrlichia ruminantium str. Welgevonden	3233460
YP_180374.1	CDS	infA	NC_005295.2	864113	864361	R	probable infA | probable translation initiation factor IF-1 | len: 82 aa | Similar to many e.g. IF1_ECOLI P02998 Translation initiation factor IF-1 (71 aa) from Escherichia coli, fasta scores: E(): 2.8e-06, 46.154% identity in 65 aa overlap | Contains Pfam match to entry PF00575 S1, S1 RNA binding domain; translation initiation factor IF-1	complement(864113..864361)	Ehrlichia ruminantium str. Welgevonden	3233516
YP_180375.1	CDS	Erum5120	NC_005295.2	864569	865660	R	possible secretion protein | len: 363 aa | Similar to many uncharacterized proteins e.g. Q87LY5 Conserved hypothetical protein (371 aa) from Vibrio parahaemolyticus, fasta scores: E(): 6.3e-27, 29.191% identity in 346 aa overlap | Contains Pfam match to entry PF00529 HlyD, HlyD family secretion protein | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 13-31; hypothetical protein	complement(864569..865660)	Ehrlichia ruminantium str. Welgevonden	3233075
YP_180376.1	CDS	Erum5130	NC_005295.2	865688	867085	R	probable dihydrolipoamide dehydrogenase, E3 component of pyruvate or 2-oxoglutarate dehydrogenase complex | len: 465 aa | Highly similar to many e.g. DLDH_ECOLI P00391 Dihydrolipoamide dehydrogenase (473 aa) from Escherichia coli, fasta scores: E(): 5.6e-52, 37.061% identity in 456 aa overlap | Contains Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase and PF02852 pyr_redox_dim, Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain | Contains PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site and PS00017 ATP/GTP-binding site motif A (P-loop) | Similar to Erum1420, Erum4941, Erum3470; dihydrolipoamide dehydrogenase	complement(865688..867085)	Ehrlichia ruminantium str. Welgevonden	3233076
YP_180377.1	CDS	Erum5140	NC_005295.2	867096	868265	R	probable exported protein | len: 389 aa | Weakly similar to several e.g. Q9HXJ7 Hypothetical protein PA3800 (380 aa) from Pseudomonas aeruginosa, fasta scores: E(): 1.9e-10, 21.407% identity in 327 aa overlap | Contains Pfam match to entry PF01011 PQQ, PQQ enzyme repeat | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.997 between residues 22 and 23; hypothetical protein	complement(867096..868265)	Ehrlichia ruminantium str. Welgevonden	3233077
YP_180378.1	CDS	gpmI	NC_005295.2	869115	870620	D	catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate; phosphoglyceromutase	869115..870620	Ehrlichia ruminantium str. Welgevonden	3233346
YP_180379.1	CDS	engA	NC_005295.2	871977	873296	R	EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA	complement(871977..873296)	Ehrlichia ruminantium str. Welgevonden	3233497
YP_180380.1	CDS	carA	NC_005295.2	873909	875033	D	catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit	873909..875033	Ehrlichia ruminantium str. Welgevonden	3233289
YP_180381.1	CDS	ispH	NC_005295.2	875837	876823	D	catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase	875837..876823	Ehrlichia ruminantium str. Welgevonden	3233375
YP_180382.1	CDS	dut	NC_005295.2	878039	878413	D	probable dut | probable deoxyuridine 5'-triphosphate nucleotidohydrolase | len: 124 aa | Similar to many e.g. DUT_ECOLI P06968 Deoxyuridine 5'-triphosphate nucleotidohydrolase (151 aa) from Escherichia coli, fasta scores: E(): 5.3e-14, 42.623% identity in 122 aa overlap. Lacks 30 amino acids at the N-terminus. | Contains Pfam match to entry PF00692 dUTPase, dUTPase; deoxyuridine 5-triphosphate nucleotidohydrolase	878039..878413	Ehrlichia ruminantium str. Welgevonden	3233494
YP_180383.1	CDS	Erum5200	NC_005295.2	879346	879957	D	conserved hypothetical protein | len: 203 aa | Similar to several from Alphaproteobacteria e.g. Q92HK1 Hypothetical protein RC0770 (188 aa) from Rickettsia conorii, fasta scores: E(): 3.7e-08, 32.639% identity in 144 aa overlap; hypothetical protein	879346..879957	Ehrlichia ruminantium str. Welgevonden	3233078
YP_180384.1	CDS	Erum5210	NC_005295.2	880973	888340	R	possible type IV secretion system protein | len: 2455 aa | Similar to the repetitive region of e.g. Q88XB6 Cell surface SD repeat protein precursor (3360 aa) from Lactobacillus plantarum, fasta scores: E(): 5.4e-23, 20.027% identity in 1468 aa overlap | Contains Pfam match to entry PF04610 TrbL, TrbL/VirB6 plasmid conjugal transfer protein, incomplete domain | Contains signal peptide predicted by SignalP2.0 HMM (Signal peptide probabilty 0.899) with cleavage site probability 0.583 between residues 25 and 26 | Contains 4 probable transmembrane helices predicted by TMHMM2.0 at aa 309-331, 424-446, 450-472 and 485-507 | Contains three tandem repeats, 261 bp repeated 5.1 times, 222 bp repeated 3.9 times, 180 bp repeated 1.9 times | Similar to Erum5220, Erum5230, Erum5240; hypothetical protein	complement(880973..888340)	Ehrlichia ruminantium str. Welgevonden	3233079
YP_180385.1	CDS	Erum5220	NC_005295.2	888358	892947	R	possible type IV secretion system protein | len: 1529 aa | Similar to the repetitive region of several e.g. Q88XB6 Cell surface SD repeat protein precursor (3360 aa) from Lactobacillus plantarum, fasta scores: E(): 4.4e-21, 26.078% identity in 487 aa overlap | Contains Pfam match to entry PF04610 TrbL, TrbL/VirB6 plasmid conjugal transfer protein | Contains 6 probable transmembrane helices predicted by TMHMM2.0 at aa 711-733, 740-759, 814-836, 843-865, 885-907 and 969-991 | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.925) with cleavage site probability 0.456 between residues 33 and 34 | Contains two tandem repeats, 216 bp repeated 2.4 times, 15 bp repeated 2.3 times | Similar to Erum5230, Erum5210, Erum5240; hypothetical protein	complement(888358..892947)	Ehrlichia ruminantium str. Welgevonden	3233080
YP_180386.1	CDS	Erum5230	NC_005295.2	892949	895684	R	possible type IV secretion system protein | len: 911 aa | Similar to several other rickettsial proteins e.g. Q92JC3 Hypothetical protein RC0144 (966 aa) from Rickettsia conorii, fasta scores: E(): 5.4e-22, 24.116% identity in 622 aa overlap | Contains Pfam match to entry PF04610 TrbL, TrbL/VirB6 plasmid conjugal transfer protein | Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site | Contains 7 probable transmembrane helices predicted by TMHMM2.0 at aa 534-556, 563-585, 643-665, 672-694, 704-726, 746-768 and 788-810 | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.500) with cleavage site probability 0.480 between residues 20 and 21 | Similar to Erum5220, Erum5210, Erum5240; hypothetical protein	complement(892949..895684)	Ehrlichia ruminantium str. Welgevonden	3233081
YP_180387.1	CDS	virB6	NC_005295.2	895822	898287	R	virB6 | type IV secretion system protein VirB6 | len: 821 aa | Similar to several e.g. Q8RPN1 VirB6 (826 aa) from Ehrlichia chaffeensis, fasta scores: E(): 6.6e-197, 68.826% identity in 818 aa overlap | Contains Pfam match to entry PF04610 TrbL, TrbL/VirB6 plasmid conjugal transfer protein | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.954 between residues 26 and 27 | Contains 8 probable transmembrane helices predicted by TMHMM2.0 at aa 59-81, 86-108, 429-451, 536-558, 565-587, 591-613, 626-645 and 723-745 | Similar to Erum5220, Erum5230, Erum5210, Erum0760; hypothetical protein	complement(895822..898287)	Ehrlichia ruminantium str. Welgevonden	3232801
YP_180388.1	CDS	virB4	NC_005295.2	898326	900728	R	virB4 | type IV secretion system protein VirB4 | len: 800 aa | Highly similar to many e.g. Q8RPN2 VirB4 (800 aa) from Ehrlichia chaffeensis, fasta scores: E(): 0, 93.250% identity in 800 aa overlap | Contains Pfam match to entry PF03135 CagE_TrbE_VirB, CagE, TrbE, VirB family, component of type IV transporter system | Contains PS00017 ATP/GTP-binding site motif A (P-loop) | Similar to Erum7980; type IV secretion system ATPase VirB4	complement(898326..900728)	Ehrlichia ruminantium str. Welgevonden	3232800
YP_180389.1	CDS	virB3	NC_005295.2	900728	901021	R	virB3 | type IV secretion system protein VirB3 | len: 97 aa | Similar to several e.g. Q8RPN3 VirB3 (97 aa) from Ehrlichia chaffeensis, fasta scores: E(): 1.7e-39, 96.907% identity in 97 aa overlap | Contains Pfam match to entry PF05101 VirB3, Type IV secretory pathway, VirB3-like protein | Contains 2 probable transmembrane helices predicted by TMHMM2.0 at aa 21-43 and 47-69; type IV secretion system protein VirB3	complement(900728..901021)	Ehrlichia ruminantium str. Welgevonden	3232799
YP_180390.1	CDS	sodB	NC_005295.2	901410	902042	R	sodB | superoxide dismutase [Fe] | len: 210 aa | Similar to many e.g. SODF_ECOLI P09157 Superoxide dismutase [Fe] (192 aa) from Escherichia coli, fasta scores: E(): 8.7e-34, 47.030% identity in 202 aa overlap | Contains Pfam match to entry PF00081 sodfe, Iron/manganese superoxide dismutases, alpha-hairpin domain and PF02777 sodfe_C, Iron/manganese superoxide dismutases, C-terminal domain | Contains PS00088 Manganese and iron superoxide dismutases signature; superoxide dismutase	complement(901410..902042)	Ehrlichia ruminantium str. Welgevonden	3232728
YP_180391.1	CDS	Erum5280	NC_005295.2	902307	903569	D	probable ABC transporter, membrane-spanning protein | len: 420 aa | C-terminus is similar to many e.g. PSTA_ECOLI P07654 Phosphate transport system permease protein (296 aa) from Escherichia coli, fasta scores: E(): 1.3e-14, 30.802% identity in 237 aa overlap | Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport system inner membrane component | Contains 6 probable transmembrane helices predicted by TMHMM2.0 at aa 29-51, 198-220, 241-263, 273-290, 336-358 and 386-408 | Similar to Erum1490; phosphate ABC transporter permease	902307..903569	Ehrlichia ruminantium str. Welgevonden	3233082
YP_180392.1	CDS	lipA	NC_005295.2	906311	907189	R	catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase	complement(906311..907189)	Ehrlichia ruminantium str. Welgevonden	3233381
YP_180393.1	CDS	Erum5300	NC_005295.2	908304	909698	R	unknown | len: 464 aa; hypothetical protein	complement(908304..909698)	Ehrlichia ruminantium str. Welgevonden	3233083
YP_180394.1	CDS	Erum5310	NC_005295.2	909761	913939	R	probable integral membrane protein | len: 1392 aa | Contains 2 probable transmembrane helices predicted by TMHMM2.0 at aa 593-612 and 698-720; hypothetical protein	complement(909761..913939)	Ehrlichia ruminantium str. Welgevonden	3233084
YP_180395.1	CDS	bccA	NC_005295.2	914152	916134	R	probable bccA | probable acetyl-/propionyl-coenzyme A carboxylase alpha chain | len: 660 aa | Highly similar to many e.g. BCCA_MYCTU P46401 Acetyl-/propionyl-coenzyme A carboxylase alpha chain (654 aa) from Mycobacterium tuberculosis, fasta scores: E(): 1.3e-75, 36.567% identity in 670 aa overlap | Contains Pfam match to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase L chain, N-terminal domain, PF02786 CPSase_L_D2, Carbamoyl-phosphate synthase L chain, ATP binding domain, PF02785 Biotin_carb_C, Biotin carboxylase C-terminal domain and PF00364 biotin_lipoyl, Biotin-requiring enzyme | Contains PS00866 Carbamoyl-phosphate synthase subdomain signature 1, PS00867 Carbamoyl-phosphate synthase subdomain signature 2 and PS00188 Biotin-requiring enzymes attachment site | Similar to Erum6310; propionyl-CoA carboxylase subunit alpha	complement(914152..916134)	Ehrlichia ruminantium str. Welgevonden	3233474
YP_180396.1	CDS	rluD	NC_005295.2	916282	917256	D	rluD | ribosomal large subunit pseudouridine synthase D | len: 324 aa | Similar to many e.g. RLUD_ECOLI P33643 Ribosomal large subunit pseudouridine synthase D (326 aa) from Escherichia coli, fasta scores: E(): 2e-26, 34.740% identity in 308 aa overlap | Contains Pfam match to entry PF01479 S4, S4 domain and PF00849 PseudoU_synth_2, RNA pseudouridylate synthase | Contains PS01129 Rlu family of pseudouridine synthase signature | Similar to Erum3210; pseudouridylate synthase	916282..917256	Ehrlichia ruminantium str. Welgevonden	3232654
YP_180397.1	CDS	lysA	NC_005295.2	919113	920375	D	probable lysA | probable diaminopimelate decarboxylase | len: 420 aa | Similar to many e.g. DCDA_BACSU P23630 Diaminopimelate decarboxylase (441 aa) from Bacillus subtilis, fasta scores: E(): 1.5e-15, 30.275% identity in 436 aa overlap | Contains Pfam match to entry PF02784 Orn_Arg_deC_N, Pyridoxal-dependent decarboxylase, pyridoxal binding domain and PF00278 Orn_DAP_Arg_deC, Pyridoxal-dependent decarboxylase, C-terminal sheet domain | Contains PS00878 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P attachment site and PS00636 Nt-dnaJ domain signature; diaminopimelate decarboxylase	919113..920375	Ehrlichia ruminantium str. Welgevonden	3233523
YP_180398.1	CDS	rpmB	NC_005295.2	923099	923401	D	required for 70S ribosome assembly; 50S ribosomal protein L28	923099..923401	Ehrlichia ruminantium str. Welgevonden	3232685
YP_180399.1	CDS	priA	NC_005295.2	923922	925901	R	priA | primosomal protein N' | len: 659 aa | Highly similar to many e.g. PRIA_ECOLI P17888 Primosomal protein N' (732 aa) from Escherichia coli, fasta scores: E(): 1.9e-58, 32.341% identity in 739 aa overlap | Contains Pfam match to entry PF00270 DEAD, DEAD/DEAH box helicase and PF00271 helicase_C, Helicase conserved C-terminal domain | Contains PS00675 Sigma-54 interaction domain ATP-binding region A signature; primosomal protein N'	complement(923922..925901)	Ehrlichia ruminantium str. Welgevonden	3233470
YP_180400.1	CDS	Erum5370	NC_005295.2	927298	928275	R	probable exported protein | len: 325 aa | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.617) with cleavage site probability 0.588 between residues 27 and 28 | Similar to Erum3450; hypothetical protein	complement(927298..928275)	Ehrlichia ruminantium str. Welgevonden	3233085
YP_180401.1	CDS	hemD	NC_005295.2	928519	929247	D	probable hemD | probable uroporphyrinogen-III synthase | len: 242 aa | Weakly similar to several uncharacterized proteins e.g. O67647 Hypothetical protein AQ_1771 (250 aa) from Aquifex aeolicus, fasta scores: E(): 3.1e-06, 23.789% identity in 227 aa overlap and Q8YJA9 Uroporphyrinogen-III synthase (235 aa) from Brucella melitensis, fasta scores: E(): 0.00095, 22.785% identity in 237 aa overlap | Contains Pfam match to entry PF02602 HEM4, Uroporphyrinogen-III synthase HemD; hypothetical protein	928519..929247	Ehrlichia ruminantium str. Welgevonden	3233513
YP_180402.1	CDS	Erum5390	NC_005295.2	930328	932046	R	possible aminopeptidase | len: 572 aa | Similar to many uncharacterized proteins e.g. Q8RG64 Xaa-Pro aminopeptidase (584 aa) from Fusobacterium nucleatum, fasta scores: E(): 1e-61, 33.731% identity in 587 aa overlap | Contains Pfam match to entry PF00557 Peptidase_M24 metallopeptidase family M24; aminopeptidase	complement(930328..932046)	Ehrlichia ruminantium str. Welgevonden	3233086
YP_180403.1	CDS	Erum5400	NC_005295.2	934218	934739	R	unknown | len: 173 aa | Weakly similar to several uncharacterized proteins e.g. Y867_RICPR Q9ZC99 Hypothetical protein RP867 (231 aa) from Rickettsia prowazekii, fasta scores: E(): 6.1e-11, 41.935% identity in 124 aa overlap | Contains Pfam match to entry PF00077 rvp, Retroviral aspartyl protease | Contains PS00141 Eukaryotic and viral aspartyl proteases active site; hypothetical protein	complement(934218..934739)	Ehrlichia ruminantium str. Welgevonden	3233087
YP_180404.1	CDS	Erum5410	NC_005295.2	934822	935649	R	conserved hypothetical protein | len: 275 aa | Similar to several e.g. Q9JTU6 Hypothetical protein NMA1628 (264 aa) from Neisseria meningitidis, fasta scores: E(): 2.2e-26, 34.182% identity in 275 aa overlap; hypothetical protein	complement(934822..935649)	Ehrlichia ruminantium str. Welgevonden	3233088
YP_180405.1	CDS	era	NC_005295.2	935639	936529	R	Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era	complement(935639..936529)	Ehrlichia ruminantium str. Welgevonden	3233499
YP_180406.1	CDS	ffh	NC_005295.2	937754	939106	R	ffh | signal recognition particle protein | len: 450 aa | Highly similar to many e.g. SR54_ECOLI P07019 Signal recognition particle protein (453 aa) from Escherichia coli, fasta scores: E(): 4.2e-59, 45.266% identity in 433 aa overlap | Contains Pfam match to entry PF02881 SRP54_N, SRP54-type protein, helical bundle domain, PF00448 SRP54, SRP54-type protein, GTPase domain and PF02978 SRP_SPB, Signal peptide binding domain | Contains 2 PS00017 ATP/GTP-binding site motif A (P-loop) | Similar to Erum8520; Signal recognition particle protein	complement(937754..939106)	Ehrlichia ruminantium str. Welgevonden	3233322
YP_180407.1	CDS	Erum5440	NC_005295.2	939091	940677	R	subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone; monovalent cation/H+ antiporter subunit D	complement(939091..940677)	Ehrlichia ruminantium str. Welgevonden	3233089
YP_180408.1	CDS	Erum5450	NC_005295.2	942096	942890	D	unknown | len: 264 aa | Similar to Erum5460, Erum5580, Erum5570, Erum5470; hypothetical protein	942096..942890	Ehrlichia ruminantium str. Welgevonden	3233090
YP_180409.1	CDS	Erum5460	NC_005295.2	943338	944114	D	unknown | len: 258 aa | Similar to Erum5450, Erum5580, Erum5570, Erum5470; hypothetical protein	943338..944114	Ehrlichia ruminantium str. Welgevonden	3233091
YP_180410.1	CDS	Erum5470	NC_005295.2	945747	946223	D	probable membrane protein | len: 158 aa | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 86-108 | Similar to Erum5580, Erum5460, Erum5570, Erum5590, Erum5450; hypothetical protein	945747..946223	Ehrlichia ruminantium str. Welgevonden	3233092
YP_180411.1	CDS	Erum5480	NC_005295.2	946401	946736	R	probable membrane protein | len: 111 aa | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 7-24. The transmembrane helix could represent a possible N-terminal signal sequence.; hypothetical protein	complement(946401..946736)	Ehrlichia ruminantium str. Welgevonden	3233093
YP_180412.1	CDS	Erum5490	NC_005295.2	946862	947323	R	conserved hypothetical protein | len: 153 aa | Similar to many e.g. Q92J61 Hypothetical protein RC0208 (146 aa) from Rickettsia conorii, fasta scores: E(): 7.8e-12, 31.081% identity in 148 aa overlap | Contains Pfam match to entry PF03654 ARPF, Aromatic-Rich Protein Family; hypothetical protein	complement(946862..947323)	Ehrlichia ruminantium str. Welgevonden	3233094
YP_180413.1	CDS	dnaK	NC_005295.2	947564	949501	R	heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK	complement(947564..949501)	Ehrlichia ruminantium str. Welgevonden	3233310
YP_180414.1	CDS	Erum5510	NC_005295.2	949576	951408	R	probable ribonuclease | len: 610 aa | Highly similar to many ribonucleases e.g. RNE_ECOLI P21513 Ribonuclease E (1061 aa) from Escherichia coli, fasta scores: E(): 1.2e-52, 38.679% identity in 530 aa overlap and RNG_ECOLI P25537 Ribonuclease G (488 aa) from Escherichia coli, fasta scores: E(): 5.3e-35, 28.305% identity in 537 aa overlap | Contains Pfam match to entry PF00575 S1, S1 RNA binding domain; ribonuclease E	complement(949576..951408)	Ehrlichia ruminantium str. Welgevonden	3233095
YP_180415.1	CDS	Erum5520	NC_005295.2	951548	951883	R	subunit C of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; monovalent cation/H+ antiporter subunit C	complement(951548..951883)	Ehrlichia ruminantium str. Welgevonden	3233096
YP_180416.1	CDS	Erum5530	NC_005295.2	951978	952397	R	subunit B of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; monovalent cation/H+ antiporter subunit B	complement(951978..952397)	Ehrlichia ruminantium str. Welgevonden	3233097
YP_180417.1	CDS	Erum5540	NC_005295.2	952390	952935	R	subunit B of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; monovalent cation/H+ antiporter subunit B	complement(952390..952935)	Ehrlichia ruminantium str. Welgevonden	3233098
YP_180418.1	CDS	Erum5550	NC_005295.2	952922	953221	R	subunit G of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; monovalent cation/H+ antiporter subunit G	complement(952922..953221)	Ehrlichia ruminantium str. Welgevonden	3233099
YP_180419.1	CDS	Erum5560	NC_005295.2	953218	953484	R	subunit F of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; monovalent cation/H+ antiporter subunit F	complement(953218..953484)	Ehrlichia ruminantium str. Welgevonden	3233100
YP_180420.1	CDS	Erum5570	NC_005295.2	955819	957477	D	unknown | len: 552 aa | Contains a tandem repeat, 183 bp repeated 3.0 times | Similar to Erum5580, Erum5460, Erum5470, Erum5450; hypothetical protein	955819..957477	Ehrlichia ruminantium str. Welgevonden	3233101
YP_180421.1	CDS	Erum5580	NC_005295.2	959222	960256	D	unknown | len: 344 aa | Similar to Erum5470, Erum5570, Erum5460, Erum5450, Erum5590; hypothetical protein	959222..960256	Ehrlichia ruminantium str. Welgevonden	3233102
YP_180422.1	CDS	Erum5590	NC_005295.2	961962	962603	D	unknown | len: 213 aa | Similar to Erum5580, Erum5470; hypothetical protein	961962..962603	Ehrlichia ruminantium str. Welgevonden	3233103
YP_180423.1	CDS	tkt	NC_005295.2	963646	965661	R	tkt | transketolase | len: 671 aa | Highly similar to many e.g. TKT2_ECOLI P33570 Transketolase 2 (667 aa) from Escherichia coli, fasta scores: E(): 7e-114, 47.554% identity in 654 aa overlap | Contains Pfam match to entry PF00456 transketolase, Transketolase, thiamine diphosphate binding domain, PF02779 transket_pyr, Transketolase, pyridine binding domain and PF02780 transketolase_C, Transketolase, C-terminal domain | Contains PS00801 Transketolase signature 1 and PS00802 Transketolase signature 2; transketolase	complement(963646..965661)	Ehrlichia ruminantium str. Welgevonden	3232741
YP_180424.1	CDS	Erum5610	NC_005295.2	965720	967195	R	possible carboxypeptidase | len: 491 aa | Similar to many uncharacterized proteins e.g. EAA25708 Thermostable carboxypeptidase (496 aa) from Rickettsia sibirica, fasta scores: E(): 4.5e-31, 25.703% identity in 498 aa overlap | Contains Pfam match to entry PF02074 Peptidase_M32, Carboxypeptidase Taq (M32) metallopeptidase; carboxypeptidase	complement(965720..967195)	Ehrlichia ruminantium str. Welgevonden	3233104
YP_180425.1	CDS	Erum5620	NC_005295.2	967934	968587	D	unknown | len: 217 aa | Weakly similar to many e.g. PAL_ECOLI P07176 Peptidoglycan-associated lipoprotein precursor (173 aa) from Escherichia coli, fasta scores: E(): 3.9e-07, 38.889% identity in 108 aa overlap | Pfam match to entry PF00691 OmpA, OmpA family; peptidoglycan-associated lipoprotein precursor	967934..968587	Ehrlichia ruminantium str. Welgevonden	3233105
YP_180426.1	CDS	purA	NC_005295.2	969382	970674	D	catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase	969382..970674	Ehrlichia ruminantium str. Welgevonden	3232628
YP_180427.1	CDS	Erum5640	NC_005295.2	972446	972916	R	possible Holliday junction resolvase | len: 156 aa | Similar to many uncharacterized proteins e.g. RUVX_ECOLI P52050  Holliday junction resolvase (138 aa) from Escherichia coli, fasta scores: E(): 7.5e-06, 28.030% identity in 132 aa overlap | Contains Pfam match to entry PF03652 UPF0081, Uncharacterised protein family (UPF0081); Holliday junction resolvase	complement(972446..972916)	Ehrlichia ruminantium str. Welgevonden	3233106
YP_180428.1	CDS	nrdA	NC_005295.2	973299	975086	R	Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha	complement(973299..975086)	Ehrlichia ruminantium str. Welgevonden	3233531
YP_180429.1	CDS	ispA	NC_005295.2	977138	977968	D	probable ispA | probable geranyltranstransferase | len: 276 aa | Similar to many e.g. ISPA_ECOLI P22939 Geranyltranstransferase (299 aa) from Escherichia coli, fasta scores: E(): 3.9e-22, 35.531% identity in 273 aa overlap | Contains Pfam match to entry PF00348 polyprenyl_synt, Polyprenyl synthetase | Contains PS00723 Polyprenyl synthetases signature 1 and PS00444 Polyprenyl synthetases signature 2 | Similar to Erum0600; geranyltranstransferase	977138..977968	Ehrlichia ruminantium str. Welgevonden	3233517
YP_180430.1	CDS	Erum5670	NC_005295.2	977971	978924	D	probable membrane protein | len: 317 aa | Almost identical to Q93FQ2 Hypothetical 13.1 kDa protein (Fragment) (115 aa) from Ehrlichia ruminantium (Gardel), fasta scores: E(): 2.2e-36, 97.391% identity in 115 aa overlap | Contains Pfam match to entry PF00254 FKBP, FKBP-type peptidyl-prolyl cis-trans isomerase | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 9-31. The transmembrane helix could represent a possible N-terminal signal sequence.; hypothetical protein	977971..978924	Ehrlichia ruminantium str. Welgevonden	3233107
YP_180431.1	CDS	thiO	NC_005295.2	980636	981700	R	probable thiO | probable thiamine biosynthesis oxidoreductase | len: 354 aa | Similar to several e.g. THIO_RHIET O34292  thiamine biosynthesis oxidoreductase thiO (327 aa) from Rhizobium etli, fasta scores: E(): 9e-24, 34.441% identity in 331 aa overlap | Contains Pfam match to entry PF01266 DAO, FAD dependent oxidoreductase | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.808) with cleavage site probability 0.318 between residues 23 and 24; thiamine biosynthesis oxidoreductase thiO	complement(980636..981700)	Ehrlichia ruminantium str. Welgevonden	3232613
YP_180432.1	CDS	Erum5690	NC_005295.2	983373	983810	R	possible deaminase | len: 145 aa | Similar to many uncharacterized proteins e.g. Y831_RICPR Q9ZCC6 Hypothetical protein RP831 (148 aa) from Rickettsia prowazekii, fasta scores: E(): 7.2e-21, 46.528% identity in 144 aa overlap | Contains Pfam match to entry PF00383 dCMP_cyt_deam, Cytidine and deoxycytidylate deaminase zinc-binding region | The C-terminus is highly similar to Erum5681; deaminase	complement(983373..983810)	Ehrlichia ruminantium str. Welgevonden	3233109
YP_180433.1	CDS	Erum5700	NC_005295.2	983952	984380	D	probable membrane protein | len: 142 aa | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 5-27; hypothetical protein	983952..984380	Ehrlichia ruminantium str. Welgevonden	3233110
YP_180434.1	CDS	dnaB	NC_005295.2	985870	987330	D	unwinds double stranded DNA; replicative DNA helicase	985870..987330	Ehrlichia ruminantium str. Welgevonden	3233307
YP_180435.1	CDS	fabH	NC_005295.2	989842	990801	R	fabH | 3-oxoacyl-[acyl-carrier-protein] synthase III | len: 319 aa | Highly similar to many e.g. FABH_ECOLI P24249 3-oxoacyl-[acyl-carrier-protein] synthase III (317 aa) from Escherichia coli, fasta scores: E(): 6.6e-48, 45.253% identity in 316 aa overlap | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 300-317; 3-oxoacyl-ACP synthase	complement(989842..990801)	Ehrlichia ruminantium str. Welgevonden	3233317
YP_180436.1	CDS	plsX	NC_005295.2	990818	991828	R	involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; glycerol-3-phosphate acyltransferase PlsX	complement(990818..991828)	Ehrlichia ruminantium str. Welgevonden	3233444
YP_180437.1	CDS	rpmF	NC_005295.2	991865	992047	R	some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32	complement(991865..992047)	Ehrlichia ruminantium str. Welgevonden	3232688
YP_180438.1	CDS	tgt	NC_005295.2	992248	993384	D	tgt | queuine tRNA-ribosyltransferase | len: 378 aa | Similar to many e.g. TGT_ECOLI P19675 Queuine tRNA-ribosyltransferase (375 aa) from Escherichia coli, fasta scores: E(): 1.1e-27, 39.687% identity in 383 aa overlap | Contains Pfam match to entry PF01702 TGT, Queuine tRNA-ribosyltransferase; queuine tRNA-ribosyltransferase	992248..993384	Ehrlichia ruminantium str. Welgevonden	3232736
YP_180439.1	CDS	pstB	NC_005295.2	994223	994984	R	ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate ABC transporter ATP-binding protein	complement(994223..994984)	Ehrlichia ruminantium str. Welgevonden	3232584
YP_180440.1	CDS	dapB	NC_005295.2	995005	995799	R	catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase	complement(995005..995799)	Ehrlichia ruminantium str. Welgevonden	3233303
YP_180441.1	CDS	Erum5780	NC_005295.2	995796	996290	R	probable monooxygenase | len: 164 aa | Similar to many e.g. NTAB_CHEHE P54990 Nitrilotriacetate monooxygenase component B (322 aa) from Chelatobacter heintzii, fasta scores: E(): 5.3e-14, 37.342% identity in 158 aa overlap | Contains Pfam match to entry PF01613 Flavin_Reduct, Flavin reductase like domain; monooxygenase	complement(995796..996290)	Ehrlichia ruminantium str. Welgevonden	3233111
YP_180442.1	CDS	ubiA	NC_005295.2	996344	997231	R	UbiA prenyltransferase family catalyzes the transfer of a prenyl group to various acceptors with hydrophobic ring structures in the biosynthesis of respiratory quinones, hemes, chlorophylls, vitamin E, and shikonin; 4-hydroxybenzoate polyprenyltransferase	complement(996344..997231)	Ehrlichia ruminantium str. Welgevonden	3232792
YP_180443.1	CDS	rpmH	NC_005295.2	999433	999567	D	in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34	999433..999567	Ehrlichia ruminantium str. Welgevonden	3232690
YP_180444.1	CDS	rnpA	NC_005295.2	999558	999926	D	probable rnpA | probable ribonuclease P protein component | len: 122 aa | Weakly similar to e.g. RNPA_BACSU P25814 Ribonuclease P protein component (116 aa) from Bacillus subtilis, fasta scores: E(): 2.1e-05, 31.579% identity in 114 aa overlap | Contains Pfam match to entry PF00825 Ribonuclease_P, Ribonuclease P, incomplete domain; hypothetical protein	999558..999926	Ehrlichia ruminantium str. Welgevonden	3232597
YP_180445.1	CDS	Erum5810	NC_005295.2	999991	1001304	D	probable integral membrane transport protein | len: 437 aa | Similar to many uncharacterized proteins e.g. YAAJ_ECOLI P30143  transporter yaaJ (476 aa) from Escherichia coli, fasta scores: E(): 8.5e-22, 23.288% identity in 438 aa overlap | Contains Pfam match to entry PF01235 Na_Ala_symp, Sodium:alanine symporter family | Contains 11 probable transmembrane helices predicted by TMHMM2.0 at aa 5-24, 51-73, 83-105, 133-153, 163-185, 192-214, 241-263, 291-313, 341-363, 376-398 and 402-424 | Similar to Erum3150; integral membrane transport protein	999991..1001304	Ehrlichia ruminantium str. Welgevonden	3233112
YP_180446.1	CDS	Erum5820	NC_005295.2	1004225	1006177	R	possible competence protein | len: 650 aa | Similar to several e.g. CME3_BACSU P39695 ComE operon protein 3 (776 aa) from Bacillus subtilis, fasta scores: E(): 8.9e-12, 25.451% identity in 499 aa overlap | Contains Pfam match to entry PF03772 Competence, Competence protein | Contains 12 probable transmembrane helices predicted by TMHMM2.0 at aa 4-18, 25-43, 48-70, 233-255, 275-297, 317-339, 343-365, 372-394, 398-420, 422-440, 460-482 and 487-509 | C-terminus ends within a tandem repeat, 142 bp repeated 10.2 times; competence locus E protein 3	complement(1004225..1006177)	Ehrlichia ruminantium str. Welgevonden	3233113
YP_180447.1	CDS	pheT	NC_005295.2	1006978	1009347	R	catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta	complement(1006978..1009347)	Ehrlichia ruminantium str. Welgevonden	3233443
YP_180448.1	CDS	rplQ	NC_005295.2	1009431	1009817	R	is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17	complement(1009431..1009817)	Ehrlichia ruminantium str. Welgevonden	3232676
YP_180449.1	CDS	rpoA	NC_005295.2	1009836	1010912	R	catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha	complement(1009836..1010912)	Ehrlichia ruminantium str. Welgevonden	3232693
YP_180450.1	CDS	rpsK	NC_005295.2	1010992	1011375	R	located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11	complement(1010992..1011375)	Ehrlichia ruminantium str. Welgevonden	3232708
YP_180451.1	CDS	rpsM	NC_005295.2	1011387	1011758	R	located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13	complement(1011387..1011758)	Ehrlichia ruminantium str. Welgevonden	3232710
YP_180452.1	CDS	adk	NC_005295.2	1011817	1012479	R	adk | adenylate kinase | len: 220 aa | Similar to many e.g. KAD_BACST P27142 Adenylate kinase (217 aa) from Bacillus stearothermophilus, fasta scores: E(): 1.6e-17, 34.906% identity in 212 aa overlap | Contains Pfam match to entry PF00406 ADK, Adenylate kinase | Contains PS00113 Adenylate kinase signature; adenylate kinase	complement(1011817..1012479)	Ehrlichia ruminantium str. Welgevonden	3233269
YP_180453.1	CDS	secY	NC_005295.2	1012464	1013762	R	forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY	complement(1012464..1013762)	Ehrlichia ruminantium str. Welgevonden	3232724
YP_180454.1	CDS	rplO	NC_005295.2	1013802	1014275	R	late assembly protein; 50S ribosomal protein L15	complement(1013802..1014275)	Ehrlichia ruminantium str. Welgevonden	3232674
YP_180455.1	CDS	rpsE	NC_005295.2	1014279	1014803	R	located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5	complement(1014279..1014803)	Ehrlichia ruminantium str. Welgevonden	3232702
YP_180456.1	CDS	rplR	NC_005295.2	1014821	1015183	R	binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18	complement(1014821..1015183)	Ehrlichia ruminantium str. Welgevonden	3232677
YP_180457.1	CDS	rplF	NC_005295.2	1015197	1015733	R	ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6	complement(1015197..1015733)	Ehrlichia ruminantium str. Welgevonden	3232667
YP_180458.1	CDS	rpsH	NC_005295.2	1015746	1016144	R	binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8	complement(1015746..1016144)	Ehrlichia ruminantium str. Welgevonden	3232705
YP_180459.1	CDS	rpsN	NC_005295.2	1016165	1016470	R	located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14	complement(1016165..1016470)	Ehrlichia ruminantium str. Welgevonden	3232711
YP_180460.1	CDS	rplE	NC_005295.2	1016480	1017013	R	part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5	complement(1016480..1017013)	Ehrlichia ruminantium str. Welgevonden	3232666
YP_180461.1	CDS	rplX	NC_005295.2	1017023	1017352	R	assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24	complement(1017023..1017352)	Ehrlichia ruminantium str. Welgevonden	3232683
YP_180462.1	CDS	rplN	NC_005295.2	1017354	1017713	R	binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14	complement(1017354..1017713)	Ehrlichia ruminantium str. Welgevonden	3232673
YP_180463.1	CDS	rpsQ	NC_005295.2	1017723	1017947	R	primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17	complement(1017723..1017947)	Ehrlichia ruminantium str. Welgevonden	3232714
YP_180464.1	CDS	rpmC	NC_005295.2	1017940	1018143	R	one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29	complement(1017940..1018143)	Ehrlichia ruminantium str. Welgevonden	3232686
YP_180465.1	CDS	rplP	NC_005295.2	1018156	1018566	R	located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16	complement(1018156..1018566)	Ehrlichia ruminantium str. Welgevonden	3232675
YP_180466.1	CDS	rpsC	NC_005295.2	1018579	1019214	R	forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3	complement(1018579..1019214)	Ehrlichia ruminantium str. Welgevonden	3232700
YP_180467.1	CDS	rplV	NC_005295.2	1019219	1019563	R	binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22	complement(1019219..1019563)	Ehrlichia ruminantium str. Welgevonden	3232681
YP_180468.1	CDS	rpsS	NC_005295.2	1019577	1019858	R	protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19	complement(1019577..1019858)	Ehrlichia ruminantium str. Welgevonden	3232716
YP_180469.1	CDS	rplB	NC_005295.2	1019862	1020692	R	one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2	complement(1019862..1020692)	Ehrlichia ruminantium str. Welgevonden	3232663
YP_180470.1	CDS	rplW	NC_005295.2	1020697	1020987	R	binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23	complement(1020697..1020987)	Ehrlichia ruminantium str. Welgevonden	3232682
YP_180471.1	CDS	rplD	NC_005295.2	1020984	1021601	R	L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4	complement(1020984..1021601)	Ehrlichia ruminantium str. Welgevonden	3232665
YP_180472.1	CDS	rplC	NC_005295.2	1021608	1022303	R	binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3	complement(1021608..1022303)	Ehrlichia ruminantium str. Welgevonden	3232664
YP_180473.1	CDS	rpsJ	NC_005295.2	1022296	1022631	R	NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10	complement(1022296..1022631)	Ehrlichia ruminantium str. Welgevonden	3232707
YP_180474.1	CDS	tufB	NC_005295.2	1022632	1023819	R	EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu	complement(1022632..1023819)	Ehrlichia ruminantium str. Welgevonden	3232790
YP_180475.1	CDS	Erum6100	NC_005295.2	1024175	1024924	D	probable tRNA/rRNA methyltransferase | len: 249 aa | Similar to many uncharacterized proteins e.g. YACO_BACSU Q06753 Hypothetical tRNA/rRNA methyltransferase (249 aa) from Bacillus subtilis, fasta scores: E(): 6e-21, 28.455% identity in 246 aa overlap | Contains Pfam match to entry PF00588 SpoU_methylase, SpoU rRNA Methylase family; RNA methyltransferase	1024175..1024924	Ehrlichia ruminantium str. Welgevonden	3233114
YP_180476.1	CDS	cmk	NC_005295.2	1024917	1025555	D	probable cmk | probable cytidylate kinase | len: 212 aa | Similar to many e.g. KCY_ECOLI P23863 Cytidylate kinase (227 aa) from Escherichia coli, fasta scores: E(): 2.1e-08, 31.818% identity in 220 aa overlap | Contains Pfam match to entry PF02224 Cytidylate_kin, Cytidylate kinase; cytidylate kinase	1024917..1025555	Ehrlichia ruminantium str. Welgevonden	3233477
YP_180477.1	CDS	rpsA	NC_005295.2	1025622	1027319	D	in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1	1025622..1027319	Ehrlichia ruminantium str. Welgevonden	3232698
YP_180478.1	CDS	Erum6130	NC_005295.2	1027329	1028198	D	probable peptidase | len: 289 aa | Similar to many e.g. SPPA_BACSU O34525  signal peptide peptidase sppA (335 aa) from Bacillus subtilis, fasta scores: E(): 1.2e-19, 35.681% identity in 213 aa overlap and SPPA_ECOLI P08395 Protease IV (618 aa) from Escherichia coli, fasta scores: E(): 5.3e-14, 36.416% identity in 173 aa overlap | Contains Pfam match to entry PF01343 Peptidase_S49, Peptidase family S49 | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 21-43; protease IV	1027329..1028198	Ehrlichia ruminantium str. Welgevonden	3233115
YP_180479.1	CDS	ihfB	NC_005295.2	1028201	1028464	D	possible ihfB | possible integration host factor beta subunit | len: 87 aa | Weakly similar to e.g. IHFB_RHOCA Q06607 Integration host factor beta-subunit (95 aa) from Rhodobacter capsulatus, fasta scores: E(): 1.8e-05, 43.077% identity in 65 aa overlap | Contains Pfam match to entry PF00216 Bac_DNA_binding, Bacterial DNA-binding protein; integration host factor beta-subunit	1028201..1028464	Ehrlichia ruminantium str. Welgevonden	3233459
YP_180480.1	CDS	Erum6150	NC_005295.2	1028498	1028791	D	unknown | len: 97 aa; hypothetical protein	1028498..1028791	Ehrlichia ruminantium str. Welgevonden	3233116
YP_180481.1	CDS	Erum6160	NC_005295.2	1028784	1029149	D	unknown | len: 121 aa; hypothetical protein	1028784..1029149	Ehrlichia ruminantium str. Welgevonden	3233117
YP_180482.1	CDS	Erum6170	NC_005295.2	1029265	1030242	D	probable integral membrane protein | len: 325 aa | Contains 5 probable transmembrane helices predicted by TMHMM2.0 at aa 76-98, 108-130, 182-204, 208-230 and 264-286; hypothetical protein	1029265..1030242	Ehrlichia ruminantium str. Welgevonden	3233118
YP_180483.1	CDS	hemH	NC_005295.2	1031468	1032409	D	protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase	1031468..1032409	Ehrlichia ruminantium str. Welgevonden	3233362
YP_180484.1	CDS	Erum6190	NC_005295.2	1033166	1034239	R	probable ATPase | len: 357 aa | Similar to e.g. YHCM_ECOLI P46442 Hypothetical protein yhcM (375 aa) from Escherichia coli, fasta scores: E(): 9.1e-24, 32.107% identity in 299 aa overlap, similar to many uncharacterized ATPases e.g. Q8YJE8  ATPase N2B (403 aa) from Brucella melitensis, fasta scores: E(): 1.9e-37, 34.605% identity in 367 aa overlap | Contains Pfam match to entry PF03969 AFG1_ATPase, AFG1-like ATPase | Contains PS00017 ATP/GTP-binding site motif A (P-loop); ATPase n2B	complement(1033166..1034239)	Ehrlichia ruminantium str. Welgevonden	3233119
YP_180485.1	CDS	Erum6200	NC_005295.2	1036753	1037058	R	unknown | len: 101 aa; hypothetical protein	complement(1036753..1037058)	Ehrlichia ruminantium str. Welgevonden	3233120
YP_180486.1	CDS	Erum6210	NC_005295.2	1038176	1039033	R	probable integral membrane protein | len: 285 aa | Similar to several e.g. Q88WF0 Integral membrane protein (289 aa) from Lactobacillus plantarum, fasta scores: E(): 1.5e-39, 42.908% identity in 282 aa overlap | Contains Pfam match to entry PF01145 Band_7, SPFH domain/Band 7 family | Contains 3 probable transmembrane helices predicted by TMHMM2.0 at aa 13-35, 39-61 and 73-95; hypothetical protein	complement(1038176..1039033)	Ehrlichia ruminantium str. Welgevonden	3233121
YP_180487.1	CDS	Erum6220	NC_005295.2	1040428	1040805	R	unknown | len: 125 aa | Contains 2 Pfam matches to entry PF00023 ank, Ankyrin repeat; hypothetical protein	complement(1040428..1040805)	Ehrlichia ruminantium str. Welgevonden	3233122
YP_180488.1	CDS	Erum6230	NC_005295.2	1040859	1041263	R	probable exported protein | len: 134 aa | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.545 between residues 23 and 24; hypothetical protein	complement(1040859..1041263)	Ehrlichia ruminantium str. Welgevonden	3233123
YP_180489.1	CDS	Erum6240	NC_005295.2	1041693	1041938	R	probable membrane protein | len: 81 aa | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 4-21. The transmembrane helix could represent a possible N-terminal signal sequence.; hypothetical protein	complement(1041693..1041938)	Ehrlichia ruminantium str. Welgevonden	3233124
YP_180490.1	CDS	recB	NC_005295.2	1042032	1044605	D	probable recB | probable exodeoxyribonuclease V beta chain | len: 857 aa | Similar to many e.g. EX5B_ECOLI P08394 Exodeoxyribonuclease V beta chain (1180 aa) from Escherichia coli, fasta scores: E(): 4.1e-07, 21.963% identity in 856 aa overlap | Contains Pfam match to entry PF00580 UvrD-helicase, UvrD/REP helicase | Contains PS00017 ATP/GTP-binding site motif A (P-loop) | Contains predicted helix-turn-helix motif | C-terminus ends within a tandem repeat, 132 bp repeated 5.4 times; exodeoxyribonuclease V beta chain	1042032..1044605	Ehrlichia ruminantium str. Welgevonden	3232589
YP_180491.1	CDS	qor	NC_005295.2	1045738	1046712	R	probable qor | probable quinone oxidoreductase | len: 324 aa | Similar to many e.g. QOR_ECOLI P28304 Quinone oxidoreductase (327 aa) from Escherichia coli, fasta scores: E(): 3.7e-31, 34.251% identity in 327 aa overlap | Contains Pfam match to entry PF00107 ADH_zinc_N, Zinc-binding dehydrogenase; quinone oxidoreductase	complement(1045738..1046712)	Ehrlichia ruminantium str. Welgevonden	3232587
YP_180492.1	CDS	Erum6270	NC_005295.2	1047964	1049745	R	probable ABC transporter, ATP-binding protein | len: 593 aa | Highly similar to many e.g. APRD_PSEAE Q03024 Alkaline protease secretion ATP-binding protein AprD (593 aa) from Pseudomonas aeruginosa, fasta scores: E(): 5.4e-72, 39.049% identity in 589 aa overlap | Contains Pfam match to entry PF00664 ABC_membrane, ABC transporter transmembrane region and PF00005 ABC_tran, ABC transporter | Contains PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop) | Contains 5 probable transmembrane helices predicted by TMHMM2.0 at aa 30-52, 62-84, 136-158, 163-185 and 262-284 | Similar to Erum6820, Erum0580, Erum2550, Erum1190, Erum5760; alkaline protease ABC transporter ATP-binding protein	complement(1047964..1049745)	Ehrlichia ruminantium str. Welgevonden	3233125
YP_180493.1	CDS	folP1	NC_005295.2	1050111	1050935	D	probable folP1 | probable dihydropteroate synthase 1 | len: 274 aa | Similar to many e.g. DHP1_ECOLI P11744 Dihydropteroate synthase type I (279 aa) from Escherichia coli, fasta scores: E(): 3.8e-10, 29.183% identity in 257 aa overlap | Contains Pfam match to entry PF00809 Pterin_bind, Pterin binding enzyme | Contains PS00792 Dihydropteroate synthase signature 1 | Highly similar to Erum6290; dihydropteroate synthase 1	1050111..1050935	Ehrlichia ruminantium str. Welgevonden	3233506
YP_180494.1	CDS	folP2	NC_005295.2	1051496	1052347	D	probable folP2 | probable dihydropteroate synthase 2 | len: 283 aa | Similar to many e.g. DHPS_NEIMB Q51161 Dihydropteroate synthase (285 aa) from Neisseria meningitidis, fasta scores: E(): 1.3e-16, 33.333% identity in 276 aa overlap | Contains Pfam match to entry PF00809 Pterin_bind, Pterin binding enzyme | Highly similar to Erum6280; dihydropteroate synthase 2	1051496..1052347	Ehrlichia ruminantium str. Welgevonden	3233507
YP_180495.1	CDS	Erum6300	NC_005295.2	1052943	1054001	R	probable integral membrane protein | len: 352 aa | Contains 2 probable transmembrane helices predicted by TMHMM2.0 at aa 265-287 and 299-321; hypothetical protein	complement(1052943..1054001)	Ehrlichia ruminantium str. Welgevonden	3233126
YP_180496.1	CDS	carB	NC_005295.2	1054334	1057561	D	four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit	1054334..1057561	Ehrlichia ruminantium str. Welgevonden	3233290
YP_180497.1	CDS	Erum6320	NC_005295.2	1060049	1060366	R	unknown | len: 105 aa; hypothetical protein	complement(1060049..1060366)	Ehrlichia ruminantium str. Welgevonden	3233127
YP_180498.1	CDS	fumC	NC_005295.2	1060479	1061864	R	class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase	complement(1060479..1061864)	Ehrlichia ruminantium str. Welgevonden	3233330
YP_180499.1	CDS	pyrC	NC_005295.2	1063863	1065212	D	pyrC | dihydroorotase | len: 449 aa | Highly similar to many e.g. PYRC_BACSU P25995 Dihydroorotase from Bacillus subtilis, fasta scores: E(): 2.9e-52, 41.623% identity in 382 aa overlap | Contains Pfam match to entry PF01979 Amidohydro_1, Amidohydrolase family | Contains PS00482 Dihydroorotase signature 1 and PS00483 Dihydroorotase signature 2; dihydroorotase	1063863..1065212	Ehrlichia ruminantium str. Welgevonden	3232640
YP_180500.1	CDS	lipB	NC_005295.2	1066371	1066997	R	lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B	complement(1066371..1066997)	Ehrlichia ruminantium str. Welgevonden	3233382
YP_180501.1	CDS	purN	NC_005295.2	1067421	1068059	R	purN | phosphoribosylglycinamide formyltransferase | len: 212 aa | Identical to Q93FS6 Hypothetical phosphoribosylamine-glycine (212 aa) from Ehrlichia ruminantium (Highway), fasta scores: E(): 4.4e-83, 100.000% identity in 212 aa overlap. Similar to many e.g. PUR3_ECOLI P08179 Phosphoribosylglycinamide formyltransferase (212 aa) from Escherichia coli, fasta scores: E(): 2.9e-24, 40.933% identity in 193 aa overlap | Contains Pfam match to entry PF00551 formyl_transf, Formyl transferase | Similar to Erum2030; phosphoribosylglycinamide formyltransferase	complement(1067421..1068059)	Ehrlichia ruminantium str. Welgevonden	3232637
YP_180502.1	CDS	pepA	NC_005295.2	1068227	1069729	R	catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase	complement(1068227..1069729)	Ehrlichia ruminantium str. Welgevonden	3233437
YP_180503.1	CDS	Erum6390	NC_005295.2	1071607	1072341	D	probable dioxygenase | len: 244 aa | Similar to other uncharacterized Rickettsial dioxygenases e.g. EAA25428 Hypothetical protocatechuate-34-dioxygenase beta subunit (208 aa) from Rickettsia sibirica, fasta scores: E(): 6.3e-11, 30.208% identity in 192 aa overlap | Contains Pfam match to entry PF00775 Dioxygenase, Dioxygenase | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 21-40; EC_number 1.3.11.-; hypothetical protein	1071607..1072341	Ehrlichia ruminantium str. Welgevonden	3233129
YP_180504.1	CDS	clpB	NC_005295.2	1074846	1077425	R	clpB | heat shock protein ClpB | len: 859 aa | Highly similar to many e.g. CLPB_ECOLI P03815 ClpB protein (Heat shock protein F84.1) (857 aa) from Escherichia coli, fasta scores: E(): 7.5e-156, 55.064% identity in 859 aa overlap | Contains 2 Pfam matches to entry PF02861 Clp_N, Clp amino terminal domain and PF00004 AAA, ATPase family associated with various cellular activities (AAA) | Contains PS00041 Bacterial regulatory proteins, araC family signature, 2 PS00017 ATP/GTP-binding site motif A (P-loop), PS00870 Chaperonins clpA/B signature 1 and PS00871 Chaperonins clpA/B signature 2 | Similar to Erum4660, Erum2020; ClpA-type chaperone	complement(1074846..1077425)	Ehrlichia ruminantium str. Welgevonden	3233296
YP_180505.1	CDS	Erum6410	NC_005295.2	1077816	1078565	D	probable oxidoreductase | len: 249 aa | Similar to many e.g. YCIK_ECOLI P31808 Hypothetical oxidoreductase yciK (252 aa) from Escherichia coli, fasta scores: E(): 4.5e-14, 30.415% identity in 217 aa overlap | Contains Pfam match to entry PF00106 adh_short, short chain dehydrogenase | Contains PS00061 Short-chain dehydrogenases/reductases family signature | Similar to Erum3840; oxidoreductase	1077816..1078565	Ehrlichia ruminantium str. Welgevonden	3233130
YP_180506.1	CDS	groEL	NC_005295.2	1080487	1082142	R	60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; molecular chaperone GroEL	complement(1080487..1082142)	Ehrlichia ruminantium str. Welgevonden	3233349
YP_180507.1	CDS	groES	NC_005295.2	1082240	1082524	R	10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES	complement(1082240..1082524)	Ehrlichia ruminantium str. Welgevonden	3233350
YP_180508.1	CDS	radC	NC_005295.2	1082789	1083481	D	radC | DNA repair protein RadC | len: 230 aa | Similar to many e.g. RADC_ECOLI P25531 DNA repair protein radC (222 aa) from Escherichia coli, fasta scores: E(): 2.4e-16, 29.327% identity in 208 aa overlap | Contains Pfam match to entry PF00633 HHH, Helix-hairpin-helix motif and PF04002 RadC, RadC, DNA repair protein | Contains PS01302 DNA repair protein radC family signature; DNA repair protein radC-like protein	1082789..1083481	Ehrlichia ruminantium str. Welgevonden	3232646
YP_180509.1	CDS	purQ	NC_005295.2	1083799	1084596	R	possible purQ | possible phosphoribosylformylglycinamidine synthase I | len: 265 aa | Similar to many uncharacterized proteins e.g. PURQ_METJA Q59042 Phosphoribosylformylglycinamidine synthase I (230 aa) from Methanococcus jannaschii, fasta scores: E(): 9.4e-20, 34.137% identity in 249 aa overlap; phosphoribosylformylglycinamidine synthase	complement(1083799..1084596)	Ehrlichia ruminantium str. Welgevonden	3233461
YP_180510.1	CDS	gidA	NC_005295.2	1086392	1088269	D	GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA	1086392..1088269	Ehrlichia ruminantium str. Welgevonden	3233336
YP_180511.1	CDS	glpX	NC_005295.2	1089212	1090132	R	type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II	complement(1089212..1090132)	Ehrlichia ruminantium str. Welgevonden	3233338
YP_180512.1	CDS	Erum6480	NC_005295.2	1090582	1091196	D	probable peptidase | len: 204 aa | Weakly similar to many lipoproteins e.g. YGER_ECOLI Q46798 Hypothetical lipoprotein ygeR precursor (251 aa) from Escherichia coli, fasta scores: E(): 5.3e-08, 28.378% identity in 148 aa overlap, lacks the N-terminal region | Contains Pfam match to entry PF01551 Peptidase_M37, Peptidase family M23/M37; lipoprotein nlpD precursor	1090582..1091196	Ehrlichia ruminantium str. Welgevonden	3233131
YP_180513.1	CDS	Erum6490	NC_005295.2	1092326	1092781	D	unknown | len: 151 aa; hypothetical protein	1092326..1092781	Ehrlichia ruminantium str. Welgevonden	3233132
YP_180514.1	CDS	bioB	NC_005295.2	1093182	1094150	D	bioB | biotin synthase | len: 322 aa | Highly similar to many e.g. BIOB_ECOLI P12996 Biotin synthase (346 aa) from Escherichia coli, fasta scores: E(): 3.7e-66, 51.768% identity in 311 aa overlap | Contains Pfam match to entry PF04055 Radical_SAM, Radical SAM superfamily; biotin synthase	1093182..1094150	Ehrlichia ruminantium str. Welgevonden	3233288
YP_180515.1	CDS	purL	NC_005295.2	1096633	1099665	D	probable purL | probable phosphoribosylformylglycinamidine synthase II | len: 1010 aa | Almost identical to Q93FR6 Hypothetical phosphoribosylformylglycinamidine synthase (fragment) (521 aa) from Ehrlichia ruminantium (Highway), fasta scores: E(): 1.1e-196, 98.656% identity in 521 aa overlap. Similar to many uncharacterized proteins e.g. CAD74209 Phosphoribosylformylglycinamidine synthase II (1009 aa) from Rhodopirellula baltica, fasta scores: E(): 3.7e-94, 39.926% identity in 814 aa overlap | Contains Pfam match to entry PF00586 AIRS, AIR synthase related protein, N-terminal domain and 2 matches to entry PF02769 AIRS_C, AIR synthase related protein, C-terminal domain | C-terminus ends within a tandem repeat, 185 bp repeated 6.2 times; phosphoribosylformylglycinamidine synthase II	1096633..1099665	Ehrlichia ruminantium str. Welgevonden	3232585
YP_180516.1	CDS	folK	NC_005295.2	1101277	1101801	D	probable folK | probable 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | len: 174 aa | Almost identical to Q93FR5 Hypothetical folic acid synthesis protein (174 aa) from Ehrlichia ruminantium (Highway), fasta scores: E(): 2.4e-64, 95.402% identity in 174 aa overlap. Similar to many e.g. HPPK_ECOLI P26281 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (158 aa) from Escherichia coli, fasta scores: E(): 8.3e-10, 33.566% identity in 143 aa overlap | Contains Pfam match to entry PF01288 HPPK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) | C-terminus ends within a tandem repeat, 124 bp repeated 4.4 times; 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase	1101277..1101801	Ehrlichia ruminantium str. Welgevonden	3233505
YP_180517.1	CDS	Erum6530	NC_005295.2	1103265	1103897	R	unknown | len: 210 aa | Almost identical to Q93FR4 Hypothetical 20.8 kDa protein (Fragment) (185 aa) from Ehrlichia ruminantium (Highway), fasta scores: E(): 2.2e-73, 98.919% identity in 185 aa overlap; hypothetical protein	complement(1103265..1103897)	Ehrlichia ruminantium str. Welgevonden	3233133
YP_180518.1	CDS	Erum6540	NC_005295.2	1104045	1105346	R	probable zinc metallopeptidase | len: 433 aa | Similar to several uncharacterized proteins e.g. YFGC_ECOLI P76568 Hypothetical protein YfgC precursor (487 aa) from Escherichia coli, fasta scores: E(): 7.8e-12, 23.653% identity in 334 aa overlap | Contains Pfam match to entry PF01435 Peptidase_M48, Peptidase family M48 | Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature | Contains 2 probable transmembrane helices predicted by TMHMM2.0 at aa 5-22 and 121-138. The initial transmembrane helix could represent a possible N-terminal signal sequence.; hypothetical protein	complement(1104045..1105346)	Ehrlichia ruminantium str. Welgevonden	3233134
YP_180519.1	CDS	Erum6550	NC_005295.2	1105554	1105919	D	conserved hypothetical protein | len: 121 aa | Similar to many e.g. YBEB_ECOLI P05848 Hypothetical protein ybeB (105 aa) from Escherichia coli, fasta scores: E(): 1.3e-06, 29.293% identity in 99 aa overlap | Contains Pfam match to entry PF02410 DUF143, Domain of unknown function DUF143; hypothetical protein	1105554..1105919	Ehrlichia ruminantium str. Welgevonden	3233135
YP_180520.1	CDS	Erum6560	NC_005295.2	1106325	1107212	D	unknown | len: 295 aa; hypothetical protein	1106325..1107212	Ehrlichia ruminantium str. Welgevonden	3233136
YP_180521.1	CDS	Erum6570	NC_005295.2	1108022	1108660	R	unknown | len: 212 aa; hypothetical protein	complement(1108022..1108660)	Ehrlichia ruminantium str. Welgevonden	3233137
YP_180522.1	CDS	purM	NC_005295.2	1108812	1109840	D	catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase	1108812..1109840	Ehrlichia ruminantium str. Welgevonden	3232636
YP_180523.1	CDS	Erum6590	NC_005295.2	1112448	1113386	R	probable integrase/recombinase XerD or XerC | len: 312 aa | Almost identical to Q93FS0 Hypothetical integrase/recombinase (Fragment) (124 aa) from Ehrlichia ruminantium (Highway), fasta scores: E(): 4e-44, 96.774% identity in 124 aa overlap. Highly similar to many e.g. XERD_ECOLI P21891 Integrase/recombinase xerD (298 aa) from Escherichia coli, fasta scores: E(): 2.6e-26, 33.788% identity in 293 aa overlap | Contains Pfam match to entry PF02899 Phage_integr_N, Phage integrase, N-terminal SAM-like domain and PF00589 Phage_integrase, Phage integrase family | Similar to Erum1180; integrase/recombinase	complement(1112448..1113386)	Ehrlichia ruminantium str. Welgevonden	3233138
YP_180524.1	CDS	gpsA	NC_005295.2	1113646	1114629	D	catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase	1113646..1114629	Ehrlichia ruminantium str. Welgevonden	3233347
YP_180525.1	CDS	Erum6610	NC_005295.2	1116012	1117427	R	probable response regulator component of a two-component regulatory system | len: 471 aa | Identical to Q93FR8 Hypothetical nitrogen assimilation regulatory protein (471 aa) from Ehrlichia ruminantium (Highway), fasta scores: E(): 5.7e-169, 100.000% identity in 471 aa overlap. Similar to many e.g. NTRC_ECOLI P06713 Nitrogen regulation protein NR(I) (469 aa) from Escherichia coli, fasta scores: E(): 1.2e-41, 33.120% identity in 468 aa overlap | Note that the sensor kinase component is absent/unattached | Contains Pfam match to entry PF00072 response_reg, Response regulator receiver domain, PF00158 Sigma54_activat, Sigma-54 interaction domain and PF02954 HTH_8, Bacterial regulatory protein, Fis family | Contains PS00688 Sigma-54 interaction domain C-terminal part signature | Contains predicted helix-turn-helix motif | Similar to Erum3220, Erum7860 and a central region is almost identical to Erum6630; nitrogen assimilation regulatory protein NtrX	complement(1116012..1117427)	Ehrlichia ruminantium str. Welgevonden	3233139
YP_180526.1	CDS	ftsQ	NC_005295.2	1117699	1118514	R	probable ftsQ | probable cell division protein FtsQ | len: 271 aa | Almost identical to Q93FR7 Hypothetical cell division protein FtsQ (198 aa) from Ehrlichia ruminantium (Highway), fasta scores: E(): 4.1e-77, 97.980% identity in 198 aa overlap. Similar to several e.g. FTSQ_CAUCR O68326 Cell division protein ftsQ homolog (302 aa) from Caulobacter crescentus, fasta scores: E(): 7.9e-09, 27.053% identity in 207 aa overlap | Contains Pfam match to entry PF03799 FtsQ, Cell division protein FtsQ | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 36-58; cell division protein FtsQ	complement(1117699..1118514)	Ehrlichia ruminantium str. Welgevonden	3233509
YP_180527.1	CDS	gshB	NC_005295.2	1119909	1120847	R	catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione; glutathione synthetase	complement(1119909..1120847)	Ehrlichia ruminantium str. Welgevonden	3233352
YP_180528.1	CDS	Erum6650	NC_005295.2	1121899	1122501	R	probable exported protein | len: 200 aa | Similar to several e.g. YRAP_ECOLI P45467 Hypothetical protein yraP precursor (191 aa) from Escherichia coli, fasta scores: E(): 1e-08, 31.351% identity in 185 aa overlap | Contains 2 Pfam matches to entry PF04972 BON, Transport-associated domain | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.358 between residues 28 and 29; hypothetical protein	complement(1121899..1122501)	Ehrlichia ruminantium str. Welgevonden	3233141
YP_180529.1	CDS	aspS	NC_005295.2	1123461	1125233	D	catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase	1123461..1125233	Ehrlichia ruminantium str. Welgevonden	3233281
YP_180530.1	CDS	Erum6670	NC_005295.2	1126787	1127419	D	probable haloacid dehalogenase-like hydrolase | len: 210 aa | Weakly similar to several phosphatases and hydrolases e.g. HPRP_BACSU Q9JMQ2 HPr(Ser) phosphatase (216 aa) from Bacillus subtilis, fasta scores: E(): 1.6e-06, 25.698% identity in 179 aa overlap | Contains Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase; phosphoglycolate phosphatase	1126787..1127419	Ehrlichia ruminantium str. Welgevonden	3233142
YP_180531.1	CDS	Erum6680	NC_005295.2	1127398	1127910	D	probable integral membrane protein | len: 170 aa | Weakly similar to e.g. Q97FE8 Uncharcterized conserved membrane protein (206 aa) from Clostridium acetobutylicum, fasta scores: E(): 0.41, 25.556% identity in 180 aa overlap | Contains Pfam match to entry PF06271 RDD, RDD family | Contains 3 probable transmembrane helices predicted by TMHMM2.0 at aa 21-40, 45-67 and 124-146; hypothetical protein	1127398..1127910	Ehrlichia ruminantium str. Welgevonden	3233143
YP_180532.1	CDS	ppdK	NC_005295.2	1128888	1131509	D	catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate phosphate dikinase	1128888..1131509	Ehrlichia ruminantium str. Welgevonden	3233467
YP_180533.1	CDS	Erum6700	NC_005295.2	1132518	1133996	D	probable NADH-quinone oxidoreductase subunit | len: 492 aa | Similar to many uncharacterized proteins e.g. Q9EV70  NADH-ubiquinone oxidoreductase subunit (568 aa) from Rhizobium meliloti, fasta scores: E(): 1.7e-62, 39.355% identity in 465 aa overlap and NUOM_RICPR Q9ZCG0 NADH-quinone oxidoreductase chain M (491 aa) from Rickettsia prowazekii, fasta scores: E(): 5.9e-25, 26.327% identity in 490 aa overlap | Contains Pfam match to entry PF00361 oxidored_q1,NADH-Ubiquinone/plastoquinone (complex I), various chains | Contains 13 probable transmembrane helices predicted by TMHMM2.0 at aa 17-36, 45-62, 92-114, 127-144,148-170, 177-199, 214-236, 260-282, 297-314, 350-372,392-414, 427-449 and 464-486 | Similar to Erum1240, Erum4770, Erum4760, Erum4780, Erum5440; NADH dehydrogenase I chain L	1132518..1133996	Ehrlichia ruminantium str. Welgevonden	3233144
YP_180534.1	CDS	Erum6710	NC_005295.2	1135704	1136480	R	conserved hypothetical protein | len: 258 aa | Similar to several e.g. Q9ZDI5 Hypothetical protein RP343 (252 aa) from Rickettsia prowazekii, fasta scores: E(): 1.1e-30, 37.603% identity in 242 aa | Homologues are present in other Alphaproteobacteria and in eukaryotes (mouse and human).; hypothetical protein	complement(1135704..1136480)	Ehrlichia ruminantium str. Welgevonden	3233145
YP_180535.1	CDS	Erum6720	NC_005295.2	1136504	1137028	R	probable c-type cytochrome | len: 174 aa | Similar to many e.g. CYCM_BRAJA P30323 Cytochrome c homolog (184 aa) from Bradyrhizobium japonicum, fasta scores: E(): 2.7e-24, 41.954% identity in 174 aa overlap | Contains Pfam match to entry PF00034 cytochrome_c, Cytochrome c | Contains PS00190 Cytochrome c family heme-binding site signature | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 9-31; cytochrome c-like protein	complement(1136504..1137028)	Ehrlichia ruminantium str. Welgevonden	3233146
YP_180536.1	CDS	folD	NC_005295.2	1139365	1140267	R	catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase	complement(1139365..1140267)	Ehrlichia ruminantium str. Welgevonden	3233324
YP_180537.1	CDS	gmk	NC_005295.2	1141725	1142354	R	gmk | guanylate kinase | len: 209 aa | Similar to many e.g. KGUA_ECOLI P24234 Guanylate kinase (207 aa) from Escherichia coli, fasta scores: E(): 7.3e-26, 40.933% identity in 193 aa overlap | Contains Pfam match to entry PF00625 Guanylate_kin, Guanylate kinase | Contains PS00856 Guanylate kinase signature; guanylate kinase	complement(1141725..1142354)	Ehrlichia ruminantium str. Welgevonden	3233345
YP_180538.1	CDS	ccmC	NC_005295.2	1144123	1144827	D	ccmC | heme exporter protein C | len: 234 aa | Similar to many e.g. CCMC_ECOLI P33929 Heme exporter protein C (245 aa) from Escherichia coli, fasta scores: E(): 7.1e-31, 42.009% identity in 219 aa overlap | Contains Pfam match to entry PF01578 CytC_asm, Cytochrome C assembly protein | Contains 6 probable transmembrane helices predicted by TMHMM2.0 at aa 12-34, 54-73, 80-102, 117-139,152-174 and 189-211; Heme exporter protein C	1144123..1144827	Ehrlichia ruminantium str. Welgevonden	3233292
YP_180539.1	CDS	ruvA	NC_005295.2	1144838	1145413	D	plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA	1144838..1145413	Ehrlichia ruminantium str. Welgevonden	3232600
YP_180540.1	CDS	ruvB	NC_005295.2	1146568	1147563	D	promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB	1146568..1147563	Ehrlichia ruminantium str. Welgevonden	3232718
YP_180541.1	CDS	bcr	NC_005295.2	1150505	1151701	R	probable bcr | probable bicyclomycin resistance protein | len: 398 aa | Similar to many e.g. BCR_ECOLI P28246 Bicyclomycin resistance protein (396 aa) from Escherichia coli, fasta scores: E(): 1.7e-28, 27.595% identity in 395 aa overlap | Contains Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter | Contains 12 probable transmembrane helices predicted by TMHMM2.0 at aa 7-26, 41-63, 76-98, 103-120, 133-155, 161-183, 208-230, 245-267, 279-301, 311-333, 340-362 and 367-389 | Similar to Erum2610; bicyclomycin resistance protein	complement(1150505..1151701)	Ehrlichia ruminantium str. Welgevonden	3233475
YP_180542.1	CDS	thyX	NC_005295.2	1153031	1153888	R	flavin dependent thymidylate synthase; ThyX; thymidylate synthase complementing protein; catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate; the enzyme from Mycobacterium tuberculosis forms homotetramers; uses FAD as a cofactor; FAD-dependent thymidylate synthase	complement(1153031..1153888)	Ehrlichia ruminantium str. Welgevonden	3232614
YP_180543.1	CDS	sdhB	NC_005295.2	1155650	1156426	R	part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit	complement(1155650..1156426)	Ehrlichia ruminantium str. Welgevonden	3232721
YP_180544.1	CDS	sdhA	NC_005295.2	1156460	1158256	R	part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit	complement(1156460..1158256)	Ehrlichia ruminantium str. Welgevonden	3232720
YP_180545.1	CDS	Erum6820	NC_005295.2	1159896	1161647	R	probable ABC transporter, ATP-binding and membrane-spanning protein | len: 583 aa | Similar to many e.g. YWJA_BACSU P45861 Hypothetical ABC transporter ATP-binding protein (575 aa) from Bacillus subtilis, fasta scores: E(): 5.4e-46, 30.261% identity in 575 aa overlap | Contains Pfam match to entry PF00664 ABC_membrane, ABC transporter transmembrane region and PF00664 ABC_membrane, ABC transporter transmembrane region | Contains PS00017 ATP/GTP-binding site motif A (P-loop) | Contains 5 probable transmembrane helices predicted by TMHMM2.0 at aa 12-34, 54-76, 155-174, 233-255 and 262-2845 | Similar to Erum6270, Erum5760, Erum0580, Erum2550, Erum1190; lipid ABC transporter ATP-binding protein	complement(1159896..1161647)	Ehrlichia ruminantium str. Welgevonden	3233147
YP_180546.1	CDS	Erum6830	NC_005295.2	1161651	1161980	R	unknown | len: 109 aa; CyaY protein	complement(1161651..1161980)	Ehrlichia ruminantium str. Welgevonden	3233148
YP_180547.1	CDS	glyA	NC_005295.2	1162178	1163443	R	catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase	complement(1162178..1163443)	Ehrlichia ruminantium str. Welgevonden	3233342
YP_180548.1	CDS	rplI	NC_005295.2	1163512	1164135	R	in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9	complement(1163512..1164135)	Ehrlichia ruminantium str. Welgevonden	3232668
YP_180549.1	CDS	rpsR	NC_005295.2	1164157	1164444	R	binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18	complement(1164157..1164444)	Ehrlichia ruminantium str. Welgevonden	3232715
YP_180550.1	CDS	rpsF	NC_005295.2	1164456	1164785	R	binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6	complement(1164456..1164785)	Ehrlichia ruminantium str. Welgevonden	3232703
YP_180551.1	CDS	Erum6880	NC_005295.2	1164912	1165523	R	probable integral membrane protein | len: 203 aa | Weakly similar to several e.g. CVPA_HAEIN P45108 Colicin V production protein homolog (163 aa) from Haemophilus influenzae, fasta scores: E(): 6.6e-07, 26.415% identity in 159 aa overlap | Contains Pfam match to entry PF02674 Colicin_V, Colicin V production protein | Contains 3 probable transmembrane helices predicted by TMHMM2.0 at aa 4-23, 60-82 and 97-119; hypothetical protein	complement(1164912..1165523)	Ehrlichia ruminantium str. Welgevonden	3233149
YP_180552.1	CDS	Erum6890	NC_005295.2	1165536	1168181	R	probable integral membrane protein | len: 881 aa | Similar to many uncharacterized proteins e.g. CAE33717 Conserved inner membrane protein (866 aa) from Bordetella bronchiseptica, fasta scores: E(): 1.1e-58, 36.497% identity in 885 aa overlap | Contains 20 probable transmembrane helices predictedby TMHMM2.0 at aa 35-57, 72-89, 96-118, 122-144, 151-170, 198-220, 232-254, 320-342, 367-389, 404-426, 453-470, 480-501, 529-551, 561-583, 590-607, 622-644, 657-679, 689-711, 716-735 and 852-871; hypothetical protein	complement(1165536..1168181)	Ehrlichia ruminantium str. Welgevonden	3233150
YP_180553.1	CDS	radA	NC_005295.2	1168805	1170157	D	Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA	1168805..1170157	Ehrlichia ruminantium str. Welgevonden	3232645
YP_180554.1	CDS	dsbE	NC_005295.2	1170154	1170654	D	probable dsbE | probable thiol:disulfide interchange protein | len: 166 aa | Similar to many e.g. DSBE_ECOLI P33926 Thiol:disulfide interchange protein (185 aa) from Escherichia coli, fasta scores: E(): 3.7e-12, 42.202% identity in 109 aa overlap | Contains PS00194 Thioredoxin family active site | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 3-20. The transmembrane helix could represent a possible N-terminal signal sequence.; Thiol:disulfide interchange protein Dsb	1170154..1170654	Ehrlichia ruminantium str. Welgevonden	3233493
YP_180555.1	CDS	Erum6920	NC_005295.2	1172960	1173181	D	conserved hypothetical protein | len: 73 aa | Similar to several mostly from other Alphaproteobacteria e.g. Y812_RICPR Q9ZCE4 Hypothetical protein RP812 (77 aa) from Rickettsia prowazekii, fasta scores: E(): 1.8e-06, 38.667% identity in 75 aa overlap | Contains Pfam match to entry PF01722 BolA, BolA-like protein; hypothetical protein	1172960..1173181	Ehrlichia ruminantium str. Welgevonden	3233151
YP_180556.1	CDS	Erum6930	NC_005295.2	1173188	1173520	D	possible glutaredoxin-related protein | len: 110 aa | Similar to many uncharacterized proteins e.g. Q89IC8 Glutaredoxin-related protein (110 aa) from Bradyrhizobium japonicum, fasta scores: E(): 1.7e-22, 55.046% identity in 109 aa overlap | Contains Pfam match to entry PF00462 glutaredoxin, Glutaredoxin | Similar to Erum8140; glutaredoxin-like protein GRLA	1173188..1173520	Ehrlichia ruminantium str. Welgevonden	3233152
YP_180557.1	CDS	ligA	NC_005295.2	1173549	1175573	D	ligA | NAD-dependent DNA ligase | len: 674 aa | Highly similar to many e.g. DNLJ_ECOLI P15042 DNA ligase (671 aa) from Escherichia coli, fasta scores: E(): 1.3e-55, 39.970% identity in 673 aa overlap | Contains Pfam match to entry PF03120 NAD-dependent DNA ligase OB-fold domain, PF03119 DNA_ligase_ZBD, NAD-dependent DNA ligase C4 zinc finger domain, PF00533 BRCT, BRCA1 C Terminus (BRCT) domain and PF01653 DNA_ligase_N, NAD-dependent DNA ligase adenylation domain | Contains PS01055 NAD-dependent DNA ligase signature 1 | C-terminus ends within a tandem repeat, 238 bp repeated 3.2 times; DNA ligase	1173549..1175573	Ehrlichia ruminantium str. Welgevonden	3233380
YP_180558.1	CDS	Erum6950	NC_005295.2	1176896	1178065	R	probable exonuclease | len: 389 aa | Similar to many e.g. RND_ECOLI P09155 Ribonuclease D (375 aa) from Escherichia coli, fasta scores: E(): 2.1e-15, 25.459% identity in 381 aa overlap | Contains only the N-terminal Pfam match to entry PF01612 3_5_exonuclease, 3'-5' exonuclease typical of Rnase D, the C-terminal Pfam match PF00570 present in RND_ECOLI is missing in Erum6950 | Contains PS00017 ATP/GTP-binding site motif A (P-loop) | Similar to Erum7870; ribonuclease D	complement(1176896..1178065)	Ehrlichia ruminantium str. Welgevonden	3233153
YP_180559.1	CDS	Erum6960	NC_005295.2	1178702	1180834	R	probable histidine kinase sensor component of a two-component regulatory system | len: 710 aa | Similar to many e.g. YYCG_BACSU Q45614 Sensor protein yycG (611 aa) from Bacillus subtilis, fasta scores: E(): 3.3e-12, 22.636% identity in 645 aa overlap | Contains Pfam match to entry PF00512 HisKA, His Kinase A (phosphoacceptor) domain, PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase and PF00672 HAMP, HAMP domain | Contains 5 probable transmembrane helices predicted by TMHMM2.0 at aa 20-42, 57-79, 96-118, 289-311 and 383-405 | Note that the regulator component is absent/unattached.; nitrogen regulation protein NtrY	complement(1178702..1180834)	Ehrlichia ruminantium str. Welgevonden	3233154
YP_180560.1	CDS	Erum6970	NC_005295.2	1181012	1181299	R	unknown | len: 95 aa | Weakly similar to e.g. Q87ZR9 Cold shock domain family protein (89 aa) from Pseudomonas syringae, fasta scores: E(): 0.0014, 33.784% identity in 74 aa overlap | Contains Pfam match to entry PF00313 CSD, 'Cold-shock' DNA-binding domain; cold shock-like protein cspA	complement(1181012..1181299)	Ehrlichia ruminantium str. Welgevonden	3233155
YP_180561.1	CDS	Erum6980	NC_005295.2	1181534	1182376	D	conserved hypothetical protein | len: 280 aa | Similar to several e.g. Q8DGD7 Tlr2381 protein (288 aa) from Synechococcus elongatus, fasta scores: E(): 3.5e-27, 37.589% identity in 282 aa overlap; hypothetical protein	1181534..1182376	Ehrlichia ruminantium str. Welgevonden	3233156
YP_180562.1	CDS	dcd	NC_005295.2	1183531	1184088	D	Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase	1183531..1184088	Ehrlichia ruminantium str. Welgevonden	3233486
YP_180563.1	CDS	purC	NC_005295.2	1184466	1185218	R	catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase	complement(1184466..1185218)	Ehrlichia ruminantium str. Welgevonden	3232630
YP_180564.1	CDS	hisS	NC_005295.2	1185385	1186629	D	catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase	1185385..1186629	Ehrlichia ruminantium str. Welgevonden	3233363
YP_180565.1	CDS	Erum7020	NC_005295.2	1187123	1190086	D	probable integral membrane protein | len: 987 aa | Almost identical to Q93FS1 Hypothetical 83.6 kDa protein (Fragment) (741 aa) from Ehrlichia ruminantium (Highway), fasta scores: E(): 0, 91.486% identity in 740 aa overlap | Contains 2 probable transmembrane helices predicted by TMHMM2.0 at aa 892-914 and 921-943; hypothetical protein	1187123..1190086	Ehrlichia ruminantium str. Welgevonden	3233157
YP_180566.1	CDS	Erum7030	NC_005295.2	1190098	1190850	R	probable disulfide oxidoreductase | len: 250 aa | Almost identical to Q93FS2 Hypothetical outer membrane protein (250 aa) from Ehrlichia ruminantium (Highway), fasta scores: E(): 1.2e-88, 98.800% identity in 250 aa overlap. Similar to e.g. Q842K0 Disulfide oxidoreductase (246 aa) from Ehrlichia chaffeensis, fasta scores: E(): 7.1e-67, 72.470% identity in 247 aa overlap | Contains Pfam match to entry PF01323 DSBA, DSBA-like thioredoxin domain | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 5-27. The transmembrane helix could represent a possible N-terminal signal sequence. | Similar to Erum7420; thiol:disulfide interchange protein dsbA	complement(1190098..1190850)	Ehrlichia ruminantium str. Welgevonden	3233158
YP_180567.1	CDS	Erum7040	NC_005295.2	1192711	1193790	D	probable cytochrome c oxidase assembly protein | len: 359 aa | Similar to several uncharacterized proteins e.g. Q92IS7 Cytochrome c oxidase assembly protein (337 aa) from Rickettsia conorii, fasta scores: E(): 6.6e-48, 40.059% identity in 337 aa overlap | Contains Pfam match to entry PF02628 COX15-CtaA, Cytochrome oxidase assembly protein | Contains 8 probable transmembrane helices predicted by TMHMM2.0 at aa 28-50, 111-130, 137-159,174-196, 209-231, 270-292, 299-321 and 331-350; cytochrome C oxidase assembly protein	1192711..1193790	Ehrlichia ruminantium str. Welgevonden	3233159
YP_180568.1	CDS	ccmA	NC_005295.2	1194233	1194874	D	ATP-binding protein; required for proper cytochrome c maturation; cytochrome c biogenesis protein CcmA	1194233..1194874	Ehrlichia ruminantium str. Welgevonden	3233291
YP_180569.1	CDS	Erum7060	NC_005295.2	1196835	1198475	R	unknown | len: 546 aa; hypothetical protein	complement(1196835..1198475)	Ehrlichia ruminantium str. Welgevonden	3233160
YP_180570.1	CDS	Erum7070	NC_005295.2	1198647	1202768	R	probable membrane protein | len: 1373 aa | Almost identical in overlapping region to Q93FS4 Hypothetical 42.6 kDa protein (Fragment) (382 aa) from Ehrlichia ruminantium (Highway), fasta scores: E(): 2.7e-66, 54.799% identity (92.670% ungapped) in 646 aa overlap | Contains two tandem repeats, 141 bp repeated 3.9 times, 198 bp repeated 5.2 times. Only one copy of the 198 bp repeat is present in Q93FS4 | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 5-27; hypothetical protein	complement(1198647..1202768)	Ehrlichia ruminantium str. Welgevonden	3233161
YP_180571.1	CDS	Erum7080	NC_005295.2	1202975	1205674	R	probable membrane protein | len: 899 aa | Highly similar to Q93FS3 Hypothetical lipoprotein (921 aa) from Ehrlichia ruminantium (Highway), fasta scores: E(): 0, 87.296% identity in 921 aa overlap | Contains PS00017 ATP/GTP-binding site motif A (P-loop) | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 21-43; hypothetical protein	complement(1202975..1205674)	Ehrlichia ruminantium str. Welgevonden	3233162
YP_180572.1	CDS	Erum7090	NC_005295.2	1206256	1206942	R	probable membrane protein | len: 228 aa | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 5-27. The transmembrane helix could represent a possible N-terminal signal sequence.; hypothetical protein	complement(1206256..1206942)	Ehrlichia ruminantium str. Welgevonden	3233163
YP_180573.1	CDS	Erum7100	NC_005295.2	1208584	1209336	R	probable membrane protein | len: 250 aa | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 26-48. The transmembrane helix could represent a possible N-terminal signal sequence.; hypothetical protein	complement(1208584..1209336)	Ehrlichia ruminantium str. Welgevonden	3233164
YP_180574.1	CDS	Erum7110	NC_005295.2	1210220	1210768	R	probable exported protein | len: 182 aa | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.760) with cleavage site probability 0.164 between residues 33 and 34; hypothetical protein	complement(1210220..1210768)	Ehrlichia ruminantium str. Welgevonden	3233165
YP_180575.1	CDS	Erum7120	NC_005295.2	1211793	1212407	R	probable exported protein | len: 204 aa | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.937) with cleavage site probability 0.914 between residues 19 and 20; hypothetical protein	complement(1211793..1212407)	Ehrlichia ruminantium str. Welgevonden	3233166
YP_180576.1	CDS	Erum7130	NC_005295.2	1213447	1214007	R	probable membrane protein | len: 186 aa | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 7-29. The transmembrane helix could represent a possible N-terminal signal sequence.; hypothetical protein	complement(1213447..1214007)	Ehrlichia ruminantium str. Welgevonden	3233167
YP_180577.1	CDS	Erum7140	NC_005295.2	1216232	1216825	R	probable membrane protein | len: 197 aa | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 5-27. The transmembrane helix could represent a possible N-terminal signal sequence.; hypothetical protein	complement(1216232..1216825)	Ehrlichia ruminantium str. Welgevonden	3233168
YP_180578.1	CDS	Erum7150	NC_005295.2	1219035	1219463	R	probable membrane protein | len: 142 aa | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 10-32; hypothetical protein	complement(1219035..1219463)	Ehrlichia ruminantium str. Welgevonden	3233169
YP_180579.1	CDS	Erum7160	NC_005295.2	1219913	1220431	R	probable membrane protein | len: 172 aa | Identical to Q93FQ4 Hypothetical lipoprotein (172 aa) from Ehrlichia ruminantium (Highway), fasta scores: E(): 1.7e-59, 100.000% identity in 172 aa overlap | Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 6-28; hypothetical protein	complement(1219913..1220431)	Ehrlichia ruminantium str. Welgevonden	3233170
YP_180580.1	CDS	Erum7170	NC_005295.2	1221098	1221664	D	responsible for recognizing base lesions in the genome and initiating base excision DNA repair; 3-methyladenine DNA glycosylase	1221098..1221664	Ehrlichia ruminantium str. Welgevonden	3233171
YP_180581.1	CDS	Erum7180	NC_005295.2	1223068	1223793	R	probable membrane protein | len: 241 aa | Almost identical to Q93FQ7 Hypothetical outer membrane protein (241 aa) from Ehrlichia ruminantium (Highway), fasta scores: E(): 1e-89, 97.925% identity in 241 aa overlap | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 5-27. The transmembrane helix could represent a possible N-terminal signal sequence.; hypothetical protein	complement(1223068..1223793)	Ehrlichia ruminantium str. Welgevonden	3233172
YP_180582.1	CDS	Erum7190	NC_005295.2	1223982	1224827	R	unknown | len: 281 aa; hypothetical protein	complement(1223982..1224827)	Ehrlichia ruminantium str. Welgevonden	3233173
YP_180583.1	CDS	Erum7200	NC_005295.2	1227561	1228643	R	unknown | len: 360 aa; hypothetical protein	complement(1227561..1228643)	Ehrlichia ruminantium str. Welgevonden	3233174
YP_180584.1	CDS	Erum7220	NC_005295.2	1229764	1230450	R	probable cytidylyltransferase | len: 228 aa | Similar to many uncharacterized proteins e.g. EAA25384 Phosphatidate cytidylyltransferase (230 aa) from Rickettsia sibirica, fasta scores: E(): 1.3e-18, 34.862% identity in 218 aa overlap. Similar to C-terminus of CDSA_ECOLI P06466 Phosphatidate cytidylyltransferase (249 aa) from Escherichia coli, fasta scores: E(): 1.1e-13, 40.458% identity in 131 aa overlap | Contains Pfam match to entry PF01148 CTP_transf_1, Cytidylyltransferase family | Contains 6 probable transmembrane helices predicted by TMHMM2.0 at aa 13-35, 40-59, 66-88, 93-112, 133-155 and 207-226 | Contains predicted helix-turn-helix motif | C-terminus ends within a tandem repeat, 181 bp repeated 1.9 times; phosphatidate cytidylyltransferase	complement(1229764..1230450)	Ehrlichia ruminantium str. Welgevonden	3233176
YP_180585.1	CDS	frr	NC_005295.2	1232478	1233035	R	Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor	complement(1232478..1233035)	Ehrlichia ruminantium str. Welgevonden	3233326
YP_180586.1	CDS	pyrH	NC_005295.2	1233065	1233799	R	Catalyzes the phosphorylation of UMP to UDP; uridylate kinase	complement(1233065..1233799)	Ehrlichia ruminantium str. Welgevonden	3232644
YP_180587.1	CDS	Erum7250	NC_005295.2	1236418	1239417	R	probable membrane protein | len: 999 aa | Weakly similar to several e.g. Q8G106 Conserved hypothetical protein (1146 aa) from Brucella suis, fasta scores: E(): 2.5e-07, 19.068% identity in 687 aa overlap | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 21-38; hypothetical protein	complement(1236418..1239417)	Ehrlichia ruminantium str. Welgevonden	3233177
YP_180588.1	CDS	rnhA	NC_005295.2	1239485	1239925	R	An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease H	complement(1239485..1239925)	Ehrlichia ruminantium str. Welgevonden	3232657
YP_180589.1	CDS	Erum7270	NC_005295.2	1241384	1241980	D	probable membrane protein | len: 198 aa | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 6-28. The transmembrane helix could represent a possible N-terminal signal sequence.; hypothetical protein	1241384..1241980	Ehrlichia ruminantium str. Welgevonden	3233178
YP_180590.1	CDS	Erum7280	NC_005295.2	1242228	1242773	D	probable membrane protein | len: 181 aa | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 45-67; hypothetical protein	1242228..1242773	Ehrlichia ruminantium str. Welgevonden	3233179
YP_180591.1	CDS	mfd	NC_005295.2	1244758	1248126	D	mfd | transcription-repair coupling factor | len: 1122 aa | Highly similar to many e.g. MFD_ECOLI P30958 Transcription-repair coupling factor (1148 aa) from Escherichia coli, fasta scores: E(): 2.7e-99, 30.496% identity in 1128 aa overlap | Contains Pfam match to entry PF03461 TRCF, TRCF domain, PF00270 DEAD, DEAD/DEAH box helicase, PF00271 helicase_C, Helicase conserved C-terminal domain and PF02559 CarD_TRCF, CarD-like/TRCF domain | Contains PS00070 Aldehyde dehydrogenases cysteine active site | Similar to Erum0420; transcription-repair coupling factor	1244758..1248126	Ehrlichia ruminantium str. Welgevonden	3233409
YP_180592.1	CDS	Erum7300	NC_005295.2	1250777	1251250	R	probable integral membrane protein | len: 157 aa | Contains 2 probable transmembrane helices predicted by TMHMM2.0 at aa 5-23 and 38-55; hypothetical protein	complement(1250777..1251250)	Ehrlichia ruminantium str. Welgevonden	3233180
YP_180593.1	CDS	Erum7310	NC_005295.2	1251862	1252470	R	probable integral membrane protein | len: 202 aa | Contains 2 probable transmembrane helices predicted by TMHMM2.0 at aa 5-24 and 74-96 | Contains PS00012 Phosphopantetheine attachment site; hypothetical protein	complement(1251862..1252470)	Ehrlichia ruminantium str. Welgevonden	3233181
YP_180594.1	CDS	Erum7320	NC_005295.2	1252956	1253756	R	probable integral membrane protein | len: 266 aa | Contains 2 probable transmembrane helices predicted by TMHMM2.0 at aa 7-24 and 95-117 | Similar to Erum7330; hypothetical protein	complement(1252956..1253756)	Ehrlichia ruminantium str. Welgevonden	3233182
YP_180595.1	CDS	Erum7330	NC_005295.2	1255216	1256091	R	probable membrane protein | len: 291 aa | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 117-139 | Contains PS00028 Zinc finger, C2H2 type, domain; hypothetical protein	complement(1255216..1256091)	Ehrlichia ruminantium str. Welgevonden	3233183
YP_180596.1	CDS	Erum7340	NC_005295.2	1258673	1259041	R	probable membrane protein | len: 122 aa | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 49-71; hypothetical protein	complement(1258673..1259041)	Ehrlichia ruminantium str. Welgevonden	3233184
YP_180597.1	CDS	Erum7350	NC_005295.2	1261431	1261868	D	probable membrane protein | len: 145 aa | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 37-59 | Similar to Erum7360; hypothetical protein	1261431..1261868	Ehrlichia ruminantium str. Welgevonden	3233185
YP_180598.1	CDS	Erum7360	NC_005295.2	1262530	1262973	D	probable membrane protein | len: 147 aa | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 38-60 | Similar to Erum7350; hypothetical protein	1262530..1262973	Ehrlichia ruminantium str. Welgevonden	3233186
YP_180599.1	CDS	Erum7370	NC_005295.2	1263605	1264114	D	probable integral membrane protein | len: 169 aa | Contains 2 probable transmembrane helices predicted by TMHMM2.0 at aa 21-40 and 55-77; hypothetical protein	1263605..1264114	Ehrlichia ruminantium str. Welgevonden	3233187
YP_180600.1	CDS	Erum7380	NC_005295.2	1264741	1265214	R	probable membrane protein | len: 157 aa | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 55-77; hypothetical protein	complement(1264741..1265214)	Ehrlichia ruminantium str. Welgevonden	3233188
YP_180601.1	CDS	ribE	NC_005295.2	1265562	1266170	D	catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha	1265562..1266170	Ehrlichia ruminantium str. Welgevonden	3232593
YP_180602.1	CDS	Erum7400	NC_005295.2	1266333	1267736	R	unknown | len: 467 aa | Weakly similar to several e.g. Q9PN28 Hypothetical protein Cj1270c (363 aa) from Campylobacter jejuni, fasta scores: E(): 7.9e-13, 28.495% identity in 372 aa overlap; hypothetical protein	complement(1266333..1267736)	Ehrlichia ruminantium str. Welgevonden	3233189
YP_180603.1	CDS	Erum7410	NC_005295.2	1268962	1270227	D	probable zinc protease | len: 421 aa | Similar to many uncharacterized proteins e.g. Y219_RICPR O05945 Hypothetical zinc protease RP219 (412 aa) from Rickettsia prowazekii, fasta scores: E(): 8e-58, 43.284% identity in 402 aa overlap | Contains Pfam match to entry PF05193 Peptidase_M16_C, Peptidase M16 inactive domain and PF00675 Peptidase_M16, Insulinase (Peptidase family M16) | Contains PS00143 Insulinase family, zinc-binding region signature | Similar to Erum8090, Erum8100; protease	1268962..1270227	Ehrlichia ruminantium str. Welgevonden	3233190
YP_180604.1	CDS	Erum7420	NC_005295.2	1271322	1272047	R	conserved hypothetical protein | len: 241 aa | Similar to several e.g. Q985U5 Hypothetical protein mlr7525 (250 aa) from Rhizobium loti, fasta scores: E(): 5.9e-17, 33.493% identity in 209 aa overlap | Contains predicted helix-turn-helix motif | Similar to Erum7030; hypothetical protein	complement(1271322..1272047)	Ehrlichia ruminantium str. Welgevonden	3233191
YP_180605.1	CDS	secB	NC_005295.2	1272105	1272629	R	molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB	complement(1272105..1272629)	Ehrlichia ruminantium str. Welgevonden	3232603
YP_180606.1	CDS	Erum7440	NC_005295.2	1272746	1273387	D	conserved hypothetical protein | len: 213 aa | Similar to several from Alphaproteobacteria e.g. Q8FY17 Conserved hypothetical protein (235 aa) from Brucella suis, fasta scores: E(): 6.7e-11, 28.959% identity in 221 aa overlap; hypothetical protein	1272746..1273387	Ehrlichia ruminantium str. Welgevonden	3233192
YP_180607.1	CDS	Erum7450	NC_005295.2	1274035	1275264	R	probable integral membrane protein | len: 409 aa | Similar to many e.g. Q83D24 Major facilitator family transporter (437 aa) from Coxiella burnetii, fasta scores: E(): 8.1e-27, 28.058% identity in 417 aa overlap | Contains 12 probable transmembrane helices predicted by TMHMM2.0 at aa 9-27, 47-69, 76-95, 105-127, 134-156, 166-185, 205-227, 247-269, 276-295, 299-321, 333-355 and 378-400; bicyclomycin resistance protein	complement(1274035..1275264)	Ehrlichia ruminantium str. Welgevonden	3233193
YP_180608.1	CDS	tmk	NC_005295.2	1275307	1275915	R	catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase	complement(1275307..1275915)	Ehrlichia ruminantium str. Welgevonden	3232615
YP_180609.1	CDS	fabD	NC_005295.2	1276149	1277111	R	probable fabD | probable malonyl CoA-acyl carrier protein transacylase | len: 320 aa | Similar to many e.g. FABD_ECOLI PP25715 Malonyl CoA-acyl carrier protein transacylase (308 aa) from Escherichia coli, fasta scores: E(): 2e-27, 33.553% identity in 304 aa overlap | Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain; malonyl CoA-ACP transacylase	complement(1276149..1277111)	Ehrlichia ruminantium str. Welgevonden	3233501
YP_180610.1	CDS	rpmE	NC_005295.2	1277274	1277501	D	RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31	1277274..1277501	Ehrlichia ruminantium str. Welgevonden	3232687
YP_180611.1	CDS	ppnK	NC_005295.2	1277519	1278310	D	catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase	1277519..1278310	Ehrlichia ruminantium str. Welgevonden	3232581
YP_180612.1	CDS	guaB	NC_005295.2	1279648	1281105	D	guaB | inosine-5'-monophosphate dehydrogenase | len: 485 aa | Highly similar to many e.g. IMDH_ECOLI P06981 Inosine-5'-monophosphate dehydrogenase (488 aa) from Escherichia coli, fasta scores: E(): 3.7e-87, 55.021% identity in 478 aa overlap | Contains Pfam match to entry PF00478 IMPDH, IMP dehydrogenase/GMP reductase domain and 2 matches to PF00571 CBS, CBS domain | Contains PS00017 ATP/GTP-binding site motif A (P-loop) and PS00487 IMP dehydrogenase/GMP reductase signature; inosine-5'-monophosphate dehydrogenase	1279648..1281105	Ehrlichia ruminantium str. Welgevonden	3233354
YP_180613.1	CDS	Erum7510	NC_005295.2	1286844	1287689	D	unknown | len: 281 aa | Similar to several uncharacterized proteins e.g. Q92I03 Hypothetical protein RC0617 (290 aa) from Rickettsia conorii, fasta scores: E(): 4.3e-31, 37.132% identity in 272 aa overlap | Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold; hypothetical protein	1286844..1287689	Ehrlichia ruminantium str. Welgevonden	3233194
YP_180614.1	CDS	pdhA	NC_005295.2	1287911	1288900	D	pdhA | pyruvate dehydrogenase E1 component, alpha subunit | len: 329 aa | Highly similar to many e.g. ODPA_RHIME Q9R9N5 Pyruvate dehydrogenase E1 component, alpha subunit (348 aa) from Rhizobium meliloti, fasta scores: E(): 8.4e-77, 61.442% identity in 319 aa overlap | Contains Pfam match to entry PF00676 E1_dehydrog, Dehydrogenase E1 component | Similar to Erum2650; pyruvate dehydrogenase E1 component, alpha subunit	1287911..1288900	Ehrlichia ruminantium str. Welgevonden	3233433
YP_180615.1	CDS	Erum7530	NC_005295.2	1289048	1289824	D	probable conjugal transfer protein | len: 258 aa | Similar to several uncharacterized proteins e.g. EAA25568 Probable conjugal transfer protein trbG precursor (250 aa) from Rickettsia sibirica, fasta scores: E(): 2.2e-36, 41.797% identity in 256 aa overlap | Contains Pfam match to entry PF03524 cagX, Conjugal transfer protein | Similar to Erum0290; conjugal transfer protein TRBG precursor	1289048..1289824	Ehrlichia ruminantium str. Welgevonden	3233195
YP_180616.1	CDS	trxA	NC_005295.2	1289915	1290238	D	trxA | thioredoxin 1 | len: 107 aa | Similar to many e.g. THIO_ECOLI P00274 Thioredoxin 1 (TRX1) (108 aa) from Escherichia coli, fasta scores: E(): 5.3e-13, 45.652% identity in 92 aa overlap | Contains Pfam match to entry PF00085 thiored, Thioredoxin | Contains PS00194 Thioredoxin family active site; thioredoxin	1289915..1290238	Ehrlichia ruminantium str. Welgevonden	3232786
YP_180617.1	CDS	Erum7550	NC_005295.2	1292163	1293404	R	conserved hypothetical protein | len: 413 aa | Similar to many e.g. Y416_RICPR Q9ZDB6 Hypothetical protein RP416 (421 aa) from Rickettsia prowazekii, fasta scores: E(): 3.1e-75, 48.642% identity in 405 aa overlap | Contains Pfam match to entry PF04055 Radical_SAM, Radical SAM superfamily and PF00919 UPF0004, Uncharacterized protein family UPF0004 | Contains PS01278 Uncharacterized protein family UPF0004 signature | Similar to Erum2620; hypothetical protein	complement(1292163..1293404)	Ehrlichia ruminantium str. Welgevonden	3233196
YP_180618.1	CDS	xseB	NC_005295.2	1294433	1294621	R	probable xseB | probable exodeoxyribonuclease VII small subunit | len: 62 aa | Similar to EX7S_CAUCR Q9A6M3 Probable exodeoxyribonuclease VII small subunit (84 aa) from Caulobacter crescentus, fasta scores: E(): 4.2e-06, 51.923% identity in 52 aa overlap | Contains Pfam match to entry PF02609 Exonuc_VII_S, Exonuclease VII small subunit; exodeoxyribonuclease VII small subunit	complement(1294433..1294621)	Ehrlichia ruminantium str. Welgevonden	3232622
YP_180619.1	CDS	Erum7570	NC_005295.2	1294686	1294979	D	probable NADH-ubiquinone oxidoreductase | len: 97 aa | Similar to several proteins from Alphaproteobacteria and eukaryotes e.g. Q9A8G5 NADH-ubiquinone oxidoreductase-related protein (101 aa) from Caulobacter crescentus, fasta scores: E(): 1.9e-13, 45.263% identity in 95 aa overlap | Contains Pfam match to entry PF04800 ETC_CI_21, ETC complex I subunit conserved region; NADH-ubiquinone oxidoreductase subunit	1294686..1294979	Ehrlichia ruminantium str. Welgevonden	3233197
YP_180620.1	CDS	Erum7580	NC_005295.2	1295622	1296536	D	probable integral membrane transport protein | len: 304 aa | Similar to several uncharacterized proteins e.g. Q9ZD99 Hypothetical protein RP443 (309 aa) from Rickettsia prowazekii, fasta scores: E(): 2.9e-37, 33.224% identity in 304 aa overlap | Contains Pfam match to entry PF03547 Auxin_eff, Auxin Efflux Carrier | Contains 10 probable transmembrane helices predicted by TMHMM2.0 at aa 4-23, 36-53, 63-85, 92-114, 118-140, 153-175, 185-207, 216-238, 251-273 and 280-302; hypothetical protein	1295622..1296536	Ehrlichia ruminantium str. Welgevonden	3233198
YP_180621.1	CDS	Erum7590	NC_005295.2	1298724	1299308	R	conserved hypothetical protein | len: 194 aa | Similar to many e.g. Q9X1A8 Hypothetical protein TM1388 (175 aa) from Thermotoga maritima, fasta scores: E(): 2.5e-16, 34.254% identity in 181 aa overlap | Contains Pfam match to entry PF03602 Cons_hypoth95, Conserved hypothetical protein 95 | Contains PS00092 N-6 Adenine-specific DNA methylases signature; methylase	complement(1298724..1299308)	Ehrlichia ruminantium str. Welgevonden	3233200
YP_180622.1	CDS	Erum7600	NC_005295.2	1299314	1300591	R	probable membrane protein | len: 425 aa | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 31-53 | The C-terminus is almost identical to Erum7581; hypothetical protein	complement(1299314..1300591)	Ehrlichia ruminantium str. Welgevonden	3233201
YP_180623.1	CDS	gltX	NC_005295.2	1304663	1305994	R	Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase	complement(1304663..1305994)	Ehrlichia ruminantium str. Welgevonden	3233340
YP_180624.1	CDS	Erum7620	NC_005295.2	1307097	1307459	D	probable integral membrane protein | len: 120 aa | Contains 3 probable transmembrane helices predicted by TMHMM2.0 at aa 15-37, 39-61 and 65-87; hypothetical protein	1307097..1307459	Ehrlichia ruminantium str. Welgevonden	3233202
YP_180625.1	CDS	thiG	NC_005295.2	1308061	1308846	R	functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate; thiazole synthase	complement(1308061..1308846)	Ehrlichia ruminantium str. Welgevonden	3232738
YP_180626.1	CDS	Erum7640	NC_005295.2	1309079	1309303	R	possible thiamin S protein | len: 74 aa | Contains Pfam match to entry PF02597 ThiS, ThiS family; hypothetical protein	complement(1309079..1309303)	Ehrlichia ruminantium str. Welgevonden	3233203
YP_180627.1	CDS	Erum7650	NC_005295.2	1309576	1310982	D	unknown | len: 468 aa; hypothetical protein	1309576..1310982	Ehrlichia ruminantium str. Welgevonden	3233204
YP_180628.1	CDS	Erum7660	NC_005295.2	1312912	1313469	R	probable NifU-related protein | len: 185 aa | Similar to several uncharacterized bacterial proteins e.g. Q8G316 NifU-related protein (190 aa) from Brucella suis, fasta scores: E(): 5e-31, 50.262% identity in 191 aa overlap | Contains Pfam match to entry PF01106 NifU-like, NifU-like domain; hypothetical protein	complement(1312912..1313469)	Ehrlichia ruminantium str. Welgevonden	3233205
YP_180629.1	CDS	Erum7661	NC_005295.2	1313648	1313902	D	unknown | len: 84 aa | Similar to the C-terminus of several hypothetical proteins e.g. Q89JW2 Bll5157 protein (241 aa) from Bradyrhizobium japonicum, fasta scores: E(): 1.7e-09, 50.000% identity in 60 aa overlap | Contains Pfam match to entry PF00226 DnaJ, DnaJ domain | Almost identical to Erum1410; hypothetical protein	1313648..1313902	Ehrlichia ruminantium str. Welgevonden	3233206
YP_180630.1	CDS	rho	NC_005295.2	1315056	1316432	R	An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho	complement(1315056..1316432)	Ehrlichia ruminantium str. Welgevonden	3232650
YP_180631.1	CDS	hslV	NC_005295.2	1317866	1318435	D	heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit	1317866..1318435	Ehrlichia ruminantium str. Welgevonden	3233366
YP_180632.1	CDS	hslU	NC_005295.2	1318438	1319904	D	heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease ATP-binding subunit HslU	1318438..1319904	Ehrlichia ruminantium str. Welgevonden	3233365
YP_180633.1	CDS	ubiE	NC_005295.2	1319921	1320613	D	ubiE | ubiquinone/menaquinone biosynthesis methyltransferase UbiE | len: 230 aa | Similar to many e.g. UBIE_ECOLI P27851 Ubiquinone/menaquinone biosynthesis methyltransferase ubiE (251 aa) from Escherichia coli, fasta scores: E(): 1.2e-33, 45.299% identity in 234 aa overlap | Contains Pfam match to entry PF01209 Ubie_methyltran, ubiE/COQ5 methyltransferase family | Contains PS01183 ubiE/COQ5 methyltransferase family | Similar to Erum0220; ubiquinone/menaquinone biosynthesis methyltransferase ubiE	1319921..1320613	Ehrlichia ruminantium str. Welgevonden	3232793
YP_180634.1	CDS	metG	NC_005295.2	1322062	1323582	R	methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase	complement(1322062..1323582)	Ehrlichia ruminantium str. Welgevonden	3233407
YP_180635.1	CDS	lysC	NC_005295.2	1323939	1325186	D	catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation.; aspartate kinase	1323939..1325186	Ehrlichia ruminantium str. Welgevonden	3233524
YP_180636.1	CDS	coxB	NC_005295.2	1325973	1326749	D	probable coxB | probable cytochrome c oxidase subunit 2 | len: 258 aa | Similar to many uncharacterized bacterial proteins e.g. COX2_RICPR Q9ZDC6 Probable cytochrome c oxidase polypeptide II (313 aa) from Rickettsia prowazekii, fasta scores: E(): 3.5e-49, 47.600% identity in 250 aa overlap | Contains Pfam match to entry PF00116 COX2, Cytochrome C oxidase subunit II, periplasmic domain and PF02790 COX2_TM, Cytochrome C oxidase subunit II, transmembrane domain | Contains PS00078 CO II and nitrous oxide reductase dinuclear copper centers signature | Contains 3 probable transmembrane helices predicted by TMHMM2.0 at aa 5-27, 47-69 and 89-106; cytochrome c oxidase polypeptide II	1325973..1326749	Ehrlichia ruminantium str. Welgevonden	3233481
YP_180637.1	CDS	coxA	NC_005295.2	1326758	1328314	D	probable coxA | probable cytochrome c oxidase subunit 1 | len: 518 aa | Highly similar to many uncharacterized bacterial proteins e.g. COX1_RICPR O54069 Probable cytochrome c oxidase polypeptide I (534 aa) from Rickettsia prowazekii, fasta scores: E(): 1.2e-150, 67.245% identity in 519 aa overlap | Contains Pfam match to entry PF00115 COX1, Cytochrome C and Quinol oxidase polypeptide I | Contains PS00077 Heme-copper oxidase catalytic subunit, copper B binding region signature | Contains 12 probable transmembrane helices by TMHMM2.0 at aa 22-44, 64-86, 107-129, 154-176, 189-211, 243-265, 272-294, 309-331, 344-366, 381-403,415-437 and 457-479; cytochrome c oxidase polypeptide I	1326758..1328314	Ehrlichia ruminantium str. Welgevonden	3233480
YP_180638.1	CDS	ctaB	NC_005295.2	1328317	1329204	D	converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase	1328317..1329204	Ehrlichia ruminantium str. Welgevonden	3233482
YP_180639.1	CDS	Erum7760	NC_005295.2	1329961	1330713	R	probable exported lipoprotein | len: 250 aa | Similar to several uncharacterized lipoproteins e.g. Y183_RICPR Q9ZDY1 Hypothetical lipoprotein RP183 precursor (251 aa) from Rickettsia prowazekii, fasta scores: E(): 4.1e-20, 32.353% identity in 204 aa overlap | Contains Pfam match to entry PF03696 UPF0169, Uncharacterised protein family (UPF0169) | Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.958) with cleavage site probability 0.721 between residues 26 and 27; hypothetical protein	complement(1329961..1330713)	Ehrlichia ruminantium str. Welgevonden	3233207
YP_180640.1	CDS	purD	NC_005295.2	1330887	1332158	D	catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase	1330887..1332158	Ehrlichia ruminantium str. Welgevonden	3232631
YP_180641.1	CDS	Erum7780	NC_005295.2	1334073	1334441	D	probable preprotein translocase subunit YajC | len: 122 aa | Similar to several hypothetical proteins e.g. Y585_RICPR Hypothetical protein RP585 (142 aa) from Rickettsia prowazekii, fasta scores: E(): 2.2e-13, 36.364% identity in 110 aa overlap. Also similar to many  membrane proteins and preprotein translocases e.g. YAJC_ECOLI P19677 Hypothetical protein yajC (110 aa) from Escherichia coli, fasta scores: E(): 8.9e-10, 37.255% identity in 102 aa overlap | Contains Pfam match to entry PF02699 YajC, Preprotein translocase subunit | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 20-42; preprotein translocase subunit YajC	1334073..1334441	Ehrlichia ruminantium str. Welgevonden	3233208
YP_180642.1	CDS	Erum7790	NC_005295.2	1335342	1336046	R	unknown | len: 234 aa; hypothetical protein	complement(1335342..1336046)	Ehrlichia ruminantium str. Welgevonden	3233209
YP_180643.1	CDS	Erum7800	NC_005295.2	1336068	1337315	R	probable outer membrane efflux protein | len: 415 aa | Similar to outer membrane proteins involved in export e.g. TOLC_ECOLI P02930 Outer membrane protein tolC precursor (495 aa) from Escherichia coli, fasta scores: E(): 3.8e-05, 24.038% identity in 416 aa overlap | Contains 2 Pfam matches to entry PF02321 OEP, Outer membrane efflux protein | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.623) with cleavage site probability 0.586 between residues 32 and 33; outer membrane protein TolC	complement(1336068..1337315)	Ehrlichia ruminantium str. Welgevonden	3233210
YP_180644.1	CDS	rplM	NC_005295.2	1338938	1339408	D	in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13	1338938..1339408	Ehrlichia ruminantium str. Welgevonden	3232672
YP_180645.1	CDS	rpsI	NC_005295.2	1339408	1339869	D	forms a direct contact with the tRNA during translation; 30S ribosomal protein S9	1339408..1339869	Ehrlichia ruminantium str. Welgevonden	3232706
YP_180646.1	CDS	argC	NC_005295.2	1339878	1340921	D	catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase	1339878..1340921	Ehrlichia ruminantium str. Welgevonden	3233272
YP_180647.1	CDS	ppa	NC_005295.2	1341167	1341688	D	ppa | inorganic pyrophosphatase | len: 173 aa | Similar to many e.g. IPYR_ECOLI Inorganic pyrophosphatase (175 aa) from Escherichia coli, fasta scores: E(): 3.7e-33, 49.697% identity in 165 aa overlap | Contains Pfam match to entry PF00719 Pyrophosphatase, Inorganic pyrophosphatase | Contains PS00387 Inorganic pyrophosphatase signature; inorganic pyrophosphatase	1341167..1341688	Ehrlichia ruminantium str. Welgevonden	3233466
YP_180648.1	CDS	Erum7850	NC_005295.2	1342532	1343161	D	unknown | len: 209 aa | Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix | Contains predicted helix-turn-helix motif | Contains PS00501 Signal peptidases I serine active site; hypothetical protein	1342532..1343161	Ehrlichia ruminantium str. Welgevonden	3233211
YP_180649.1	CDS	Erum7860	NC_005295.2	1343538	1344341	D	probable response regulator component of a two-component regulatory system | len: 267 aa | Similar to many response regulators including cell cycle transcriptional regulators e.g. CTRA_CAUCR Q45994 Cell cycle transcriptional regulator (231 aa), fasta scores: E(): 4.4e-43, 54.626% identity in 227 aa overlap | Note that the sensor kinase component is absent/unattached | Contains Pfam match to entry PF00072 response_reg, Response regulator receiver domain and PF00486 trans_reg_C, Transcriptional regulatory protein, C terminal | Similar to Erum3220, Erum6610, Erum6630; hypothetical protein	1343538..1344341	Ehrlichia ruminantium str. Welgevonden	3233212
YP_180650.1	CDS	Erum7870	NC_005295.2	1344412	1345029	D	possible exonuclease | len: 205 aa | Similar to many uncharacterized proteins e.g. Q9A2G2 Ribonuclease D, (205 aa) from Caulobacter crescentus, fasta scores: E(): 1.9e-45, 55.340% identity in 206 aa overlap. However, only weakly similar to the first 170 residues of RND_ECOLI P09155 Ribonuclease D (375 aa) from Escherichia coli, fasta scores: E(): 0.00021, 32.468% identity in 154 aa overlap | Contains Pfam match to entry PF01612 3_5_exonuclease, 3'-5' exonuclease | Similar to Erum6950; ribonuclease D	1344412..1345029	Ehrlichia ruminantium str. Welgevonden	3233213
YP_180651.1	CDS	dnaN	NC_005295.2	1345111	1346238	D	dnaN | DNA polymerase III, beta subunit | len: 375 aa | Similar to many e.g. DP3B_ECOLI P00583 DNA polymerase III, beta chain (366 aa) from Escherichia coli, fasta scores: E(): 1.7e-31, 28.302% identity in 371 aa overlap | Contains Pfam match to entry PF00712 DNA_pol3_beta, DNA polymerase III beta subunit, N-terminal domain, PF02767 DNA_pol3_beta_2, DNA polymerase III beta subunit, central domain and PF02768 DNA_pol3_beta_3, DNA polymerase III beta subunit, C-terminal domain; DNA polymerase III, beta chain	1345111..1346238	Ehrlichia ruminantium str. Welgevonden	3233311
YP_180652.1	CDS	Erum7890	NC_005295.2	1348647	1349696	R	conserved hypothetical protein | len: 349 aa | Similar to many mrp family members e.g. MRP_ECOLI P21590 Mrp protein (369 aa) from Escherichia coli, fasta scores: E(): 1.3e-38, 40.418% identity in 287 aa overlap | Contains Pfam match to entry PF01883 DUF59, Domain of unknown function DUF59 | Contains PS00017 ATP/GTP-binding site motif A (P-loop) and PS01215 Mrp family signature; ATPase	complement(1348647..1349696)	Ehrlichia ruminantium str. Welgevonden	3233214
YP_180653.1	CDS	prsA	NC_005295.2	1349820	1350776	D	prsA | ribose-phosphate pyrophosphokinase | len: 318 aa | Similar to many e.g. KPRS_ECOLI P08330 Ribose-phosphate pyrophosphokinase (314 aa) from Escherichia coli, fasta scores: E(): 1.1e-22, 34.713% identity in 314 aa overlap | Contains Pfam match to entry PF00156 Pribosyltran, Phosphoribosyl transferase domain | Contains PS00103 Purine/pyrimidine phosphoribosyl transferases signature; ribose-phosphate pyrophosphokinase	1349820..1350776	Ehrlichia ruminantium str. Welgevonden	3232626
YP_180654.1	CDS	gatC	NC_005295.2	1351586	1351930	D	probable gatC | probable glutamyl-tRNA(Gln) amidotransferase subunit C | len: 114 aa | Weakly similar to several e.g. GATC_BACSU Glutamyl-tRNA(Gln) amidotransferase subunit C (96 aa) from Bacillus subtilis, fasta scores: E(): 0.00034, 24.211% identity in 95 aa overlap | Contains Pfam match to entry PF02686 Glu-tRNAGln, Glu-tRNAGln amidotransferase C subunit; glutamyl-tRNA(Gln) amidotransferase subunit C	1351586..1351930	Ehrlichia ruminantium str. Welgevonden	3233511
YP_180655.1	CDS	acnA	NC_005295.2	1353016	1355643	R	Catalyzes the conversion of citrate to isocitrate; aconitate hydratase	complement(1353016..1355643)	Ehrlichia ruminantium str. Welgevonden	3233267
YP_180656.1	CDS	apaG	NC_005295.2	1357038	1357442	R	protein associated with Co2+ and Mg2+ efflux; ApaG	complement(1357038..1357442)	Ehrlichia ruminantium str. Welgevonden	3233215
YP_180657.1	CDS	purK	NC_005295.2	1358740	1359819	D	purK | phosphoribosylaminoimidazole carboxylase ATPase subunit | len: 359 aa | Similar to many e.g. PURK_BACSU P12045 Phosphoribosylaminoimidazole carboxylase ATPase subunit (379 aa) from Bacillus subtilis, fasta scores: E(): 1.8e-48, 39.943% identity in 353 aa overlap | Contains Pfam match to entry PF02222 ATP-grasp, ATP-grasp domain; phosphoribosylaminoimidazole carboxylase ATPase subunit	1358740..1359819	Ehrlichia ruminantium str. Welgevonden	3232635
YP_180658.1	CDS	Erum7950	NC_005295.2	1361106	1363313	R	probable ATP/GTP-binding membrane protein | len: 735 aa | Similar to C-terminus of Q9AGZ1 Hypothetical 62.1 kDa protein (Fragment) (534 aa) from Ehrlichia canis, fasta scores: E(): 1.7e-32, 52.998% identity in 517 aa overlap | Contains PS00017 ATP/GTP-binding site motif A (P-loop) | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 12-31 | Similar to Erum7960, Erum7970; hypothetical protein	complement(1361106..1363313)	Ehrlichia ruminantium str. Welgevonden	3233216
YP_180659.1	CDS	Erum7960	NC_005295.2	1365790	1369704	R	unknown | len: 1304 aa | BLASTP similarity to Q9AGZ1 Hypothetical 62.1 kDa protein (Fragment) from Ehrlichia canis, blastp scores: Expect = 4e-19, Identities = 119/483 (24%) | Contains PS00017 ATP/GTP-binding site motif A (P-loop) | Contains a tandem repeat, 15 bp repeated 2.7 times | Similar to Erum7970, Erum7950; hypothetical protein	complement(1365790..1369704)	Ehrlichia ruminantium str. Welgevonden	3233217
YP_180660.1	CDS	Erum7970	NC_005295.2	1370886	1376018	R	probable exported protein | len: 1710 aa | BLASTP similarity to Q9AGZ1 Hypothetical 62.1 kDa protein (Fragment) from Ehrlichia canis, blastp scores: Expect = 1e-25, Identities = 145/528 (27%) | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.984) with cleavage site probability 0.983 between residues 24 and 25 | Similar to Erum7960, Erum7950; hypothetical protein	complement(1370886..1376018)	Ehrlichia ruminantium str. Welgevonden	3233218
YP_180661.1	CDS	Erum7980	NC_005295.2	1377584	1379956	R	possible type IV secretion system protein | len: 790 aa | Similar to many e.g. Q8RPM6 VirB4 (801 aa) from Anaplasma phagocytophilum, fasta scores: E(): 1.1e-54, 26.081% identity in 786 aa overlap | Contains Pfam match to entry PF03135 CagE_TrbE_VirB, CagE, TrbE, VirB family, component of type IV transporter system | Similar to Erum5250; VirB4 protein	complement(1377584..1379956)	Ehrlichia ruminantium str. Welgevonden	3233219
YP_180662.1	CDS	Erum7990	NC_005295.2	1381634	1382011	R	probable integral membrane protein | len: 125 aa | Similar to several other hypothetical proteins all from Anaplasma marginale e.g. Q84HV0 Hypothetical protein (125 aa), fasta scores: E(): 1e-22, 64.655% identity in 116 aa overlap | Contains 3 probable transmembrane helices predicted by TMHMM2.0 at aa 4-21, 45-67 and 72-89 | Similar to Erum8000, Erum8010, Erum8020; hypothetical protein	complement(1381634..1382011)	Ehrlichia ruminantium str. Welgevonden	3233220
YP_180663.1	CDS	Erum8000	NC_005295.2	1382305	1382643	R	probable integral membrane protein | len: 112 aa | Similar to several other hypothetical proteins all from Anaplasma marginale e.g. Q84HV0 Hypothetical protein (125 aa), fasta scores: E(): 9.4e-22, 70.707% identity in 99 aa overlap | Contains 3 probable transmembrane helices predicted by TMHMM2.0 at aa 4-26, 38-60 and 70-92 | Similar to Erum7990, Erum8010, Erum8020; hypothetical protein	complement(1382305..1382643)	Ehrlichia ruminantium str. Welgevonden	3233221
YP_180664.1	CDS	Erum8010	NC_005295.2	1383588	1383944	R	probable integral membrane protein | len: 118 aa | Similar to several other hypothetical proteins all from Anaplasma marginale e.g. Q84HV5 Hypothetical protein (128 aa), fasta scores: E(): 9.9e-22, 61.864% identity in 118 aa overlap | Contains 3 probable transmembrane helices predicted by TMHMM2.0 at aa 4-23, 43-65 and 70-87 | Similar to Erum8000, Erum7990, Erum8020; hypothetical protein	complement(1383588..1383944)	Ehrlichia ruminantium str. Welgevonden	3233222
YP_180665.1	CDS	Erum8020	NC_005295.2	1385407	1385781	R	probable integral membrane protein | len: 124 aa | Similar to several other hypothetical proteins all from Anaplasma marginale e.g. Q84HV5 Hypothetical protein (128 aa), fasta scores: E(): 7.3e-23, 63.063% identity in 111 aa overlap | Contains 3 probable transmembrane helices predicted by TMHMM2.0 at aa 10-31, 52-74 and 78-100 | Similar to Erum7990, Erum8010, Erum8000; hypothetical protein	complement(1385407..1385781)	Ehrlichia ruminantium str. Welgevonden	3233223
YP_180666.1	CDS	hflK	NC_005295.2	1386587	1387657	D	possible hflK | possible HflK protein | len: 356 aa | Similar to many Band 7 family proteins e.g. HFLK_ECOLI P25662 HflK protein (419 aa) from Escherichia coli, fasta scores: E(): 4.4e-23, 32.231% identity in 363 aa overlap | Contains Pfam match to entry PF01145 Band_7, SPFH domain/Band 7 family; protease activity modulator hflk	1386587..1387657	Ehrlichia ruminantium str. Welgevonden	3233456
YP_180667.1	CDS	hflC	NC_005295.2	1387669	1388541	D	possible hflC | possible HflC membrane protein | len: 290 aa | Similar to many Band 7 family proteins e.g. HFLC_ECOLI P25661 HflC protein (334 aa) from Escherichia coli, fasta scores: E(): 1.8e-14, 30.303% identity in 330 aa overlap | Contains Pfam match to entry PF01145 Band_7, SPFH domain/Band 7 family | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 7-29. The transmembrane helix could represent a possible N-terminal signal sequence.; Hflc protein	1387669..1388541	Ehrlichia ruminantium str. Welgevonden	3233455
YP_180668.1	CDS	Erum8050	NC_005295.2	1388541	1389971	D	probable exported serine protease | len: 476 aa | Similar to many serine proteases e.g. DEGP_RHIME Q52894 Probable serine protease do-like precursor (504 aa) from Rhizobium meliloti, fasta scores: E(): 8.5e-42, 33.534% identity in 498 aa overlap | Contains Pfam match to entry PF00089 trypsin, Trypsin and 2 matches to PF00595 PDZ, PDZ domain (Also known as DHR or GLGF) | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.501 between residues 22 and 23; serine protease do-like precursor	1388541..1389971	Ehrlichia ruminantium str. Welgevonden	3233224
YP_180669.1	CDS	Erum8060	NC_005295.2	1389979	1390593	D	probable exported protein | len: 204 aa | Weakly similar to several other rickettsial proteins e.g. Y864_RICPR Q9ZCA2 Hypothetical protein RP864 precursor (213 aa) from Rickettsia prowazekii, fasta scores: E(): 6.5e-06, 24.862% identity in 181 aa overlap | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.906) with cleavage site probability 0.695 between residues 26 and 27; hypothetical protein	1389979..1390593	Ehrlichia ruminantium str. Welgevonden	3233225
YP_180670.1	CDS	rnc	NC_005295.2	1390594	1391277	D	cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III	1390594..1391277	Ehrlichia ruminantium str. Welgevonden	3232656
YP_180671.1	CDS	ctaG	NC_005295.2	1391274	1391807	D	involved in the insertion of copper into subunit I of cytochrome C oxidase; cytochrome C oxidase assembly protein	1391274..1391807	Ehrlichia ruminantium str. Welgevonden	3233300
YP_180672.1	CDS	Erum8090	NC_005295.2	1393188	1394504	D	probable exported peptidase | len 438 aa | Similar to many other proteases e.g. MPPB_LENED Q9Y8B5 Mitochondrial processing peptidase beta subunit (466 aa) from Lentinula edodes, fasta scores: E(): 1.1e-14, 22.249% identity in 409 aa overlap and YMXG_BACSU Q04805 Hypothetical zinc protease ymxG (409 aa) from Bacillus subtilis, fasta scores: E(): 5.4e-14, 24.460% identity in 417 aa overlap | Contains Pfam match to entry PF00675 Peptidase_M16, Insulinase (Peptidase family M16) and PF05193 Peptidase_M16_C, Peptidase M16 inactive domain | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.927) with cleavage site probability 0.660 between residues 21 and 22 | Similar to Erum7410, Erum8100; protease	1393188..1394504	Ehrlichia ruminantium str. Welgevonden	3233226
YP_180673.1	CDS	Erum8100	NC_005295.2	1394507	1395874	D	probable exported M16 family peptidase | len 455 aa | Similar to many proteases and peptidases e.g. Q8GHF7 Protease B (469 aa) from Ehrlichia canis, fasta scores: E(): 9.1e-111, 67.991% identity in 453 aa overlap and YMXG_BACSU Q04805 Hypothetical zinc protease ymxG from Bacillus subtilis, fasta scores: E(): 2.1e-14, 22.010% identity in 418 aa overlap | Contains Pfam match to entry PF00675 Peptidase_M16, Insulinase (Peptidase family M16) and Pfam match to entry PF05193 Peptidase_M16_C, Peptidase M16 inactive domain. Note that the H-x-x-E-H motif involved in enzymatic activity is missing and this may therefore be a non active enzyme. | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.666) with cleavage site probability 0.590 between residues 23 and 24 | Similar to Erum7410, Erum8090; M16 family peptidase	1394507..1395874	Ehrlichia ruminantium str. Welgevonden	3233227
YP_180674.1	CDS	Erum8110	NC_005295.2	1397757	1398431	D	probable integral membrane protein | len: 224 aa | Weakly similar to Q8GHF6 Hypothetical protein (225 aa) from Ehrlichia canis, fasta scores: E(): 2.9e-07, 24.731% identity in 186 aa overlap | Contains 4 probable transmembrane helices predicted by TMHMM2.0 at aa 27-46, 61-83, 111-133 and 148-170; hypothetical protein	1397757..1398431	Ehrlichia ruminantium str. Welgevonden	3233228
YP_180675.1	CDS	lspA	NC_005295.2	1398689	1399138	R	lspA | lipoprotein signal peptidase | len: 149 aa | Similar to many e.g. LSPA_STAAU P31024 Lipoprotein signal peptidase (163 aa) from Staphylococcus aureus, fasta scores: E(): 2.9e-10, 33.987% identity in 153 aa overlap | Contains Pfam match to entry PF01252 Peptidase_A8, Signal peptidase (SPase) II | Contains 3 probable transmembrane helices predicted by TMHMM2.0 at aa 4-26, 57-79 and 118-140; lipoprotein signal peptidase	complement(1398689..1399138)	Ehrlichia ruminantium str. Welgevonden	3233385
YP_180676.1	CDS	ribF	NC_005295.2	1399135	1400055	R	ribF | riboflavin kinase/FAD synthetase | len: 306 aa | Similar to many e.g. RIBF_ECOLI Riboflavin biosynthesis protein ribF (313 aa) from Escherichia coli, fasta scores: E(): 1.4e-29, 32.686% identity in 309 aa overlap | Contains Pfam match to entry PF01687 FAD_Synth, Riboflavin kinase/FAD synthetase; riboflavin biosynthesis protein ribF	complement(1399135..1400055)	Ehrlichia ruminantium str. Welgevonden	3232653
YP_180677.1	CDS	grxC	NC_005295.2	1400099	1400386	D	probable grxC | probable glutaredoxin 3 | len: 95 aa | Similar to many e.g. GLR3_ECOLI Glutaredoxin 3 (Grx3) (82 aa) from Escherichia coli, fasta scores: E(): 5.7e-12, 53.947% identity in 76 aa overlap | Contains Pfam match to entry PF00462 glutaredoxin, Glutaredoxin | Similar to Erum6930; glutaredoxin	1400099..1400386	Ehrlichia ruminantium str. Welgevonden	3233512
YP_180678.1	CDS	Erum8150	NC_005295.2	1401178	1402020	R	probable methyltransferase | len: 280 aa | Similar to many e.g. HEMK_ECOLI P37186 Protein methyltransferase hemK (277 aa) from Escherichia coli, fasta scores: E(): 1.2e-14, 26.953% identity in 256 aa overlap | Contains PS00092 N-6 Adenine-specific DNA methylases signature; bifunctional methyltransferase HemK/tRNA (guanine-N(7)-)-methyltransferase protoporphyrinogen oxidase	complement(1401178..1402020)	Ehrlichia ruminantium str. Welgevonden	3233229
YP_180679.1	CDS	map	NC_005295.2	1402027	1402827	R	catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase	complement(1402027..1402827)	Ehrlichia ruminantium str. Welgevonden	3233388
YP_180680.1	CDS	Erum8170	NC_005295.2	1403990	1405108	R	unknown | len: 372 aa | Similar to the C-terminus of Q93FT8 Hypothetical 46.0 kDa protein (Fragment) (409 aa) from Ehrlichia ruminantium (Highway), fasta scores: E(): 5.4e-17, 35.602% identity in 191 aa overlap | Similar to the C-terminus of Erum8190, Erum8340, Erum0690, Erum0700; hypothetical protein	complement(1403990..1405108)	Ehrlichia ruminantium str. Welgevonden	3233231
YP_180681.1	CDS	Erum8180	NC_005295.2	1405121	1405573	R	unknown | len: 150 aa | Similar to the N-terminus of Q93FT8 Hypothetical 46.0 kDa protein (Fragment) (409 aa) from Ehrlichia ruminantium (Highway), fasta scores: E(): 3.6e-10, 41.135% identity in 141 aa overlap | Similar to the N-terminus of Erum8190; hypothetical protein	complement(1405121..1405573)	Ehrlichia ruminantium str. Welgevonden	3233232
YP_180682.1	CDS	Erum8190	NC_005295.2	1406796	1408487	R	unknown | len: 563 aa | Identical to Q93FT8 Hypothetical 46.0 kDa protein (Fragment) (409 aa) from Ehrlichia ruminantium (Highway), fasta scores: E(): 4e-157, 100.000% identity in 409 aa overlap | The C-terminus is similar to Erum8170, the N-terminus is similar to Erum8180. Similar to Erum8340; hypothetical protein	complement(1406796..1408487)	Ehrlichia ruminantium str. Welgevonden	3233233
YP_180683.1	CDS	sucB	NC_005295.2	1409647	1410855	R	sucB | dihydrolipoamide succinyltransferase, E2 component of 2-oxoglutarate dehydrogenase complex | len: 402 aa | Almost identical to Q93FT9 Hypothetical dihydrolipoamide acetyltransferase component (402 aa) from Ehrlichia ruminantium (Highway), fasta scores: E(): 9.6e-144, 99.751% identity in 402 aa overlap. Highly similar to many e.g. ODO2_ECOLI P07016 Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex (404 aa) from Escherichia coli, fasta scores: E(): 3.1e-58, 42.752% identity in 407 aa overlap | Contains Pfam match to entry PF00364 biotin_lipoyl, Biotin-requiring enzyme, PF02817 e3_binding, e3 binding domain and PF00198 2-oxoacid_dh, 2-oxoacid dehydrogenases acyltransferase (catalytic domain) | Contains PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site | Similar to Erum0670; 2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase subunit	complement(1409647..1410855)	Ehrlichia ruminantium str. Welgevonden	3232731
YP_180684.1	CDS	Erum8210	NC_005295.2	1411439	1411957	R	possible transferase | len: 172 aa | Almost identical to Q93FU0 Hypothetical ferripyochelin binding protein (172 aa) from Ehrlichia ruminantium (Highway), fasta scores: E(): 4.3e-62, 98.256% identity in 172 aa overlap. Similar to several  transferases e.g. YRDA_ECOLI P45770 Protein yrdA (184 aa) from Escherichia coli, fasta scores: E(): 3.1e-20, 40.828% identity in 169 aa overlap | Contains 5 Pfam matches to entry PF00132 hexapep, Bacterial transferase hexapeptide (three repeats); hypothetical protein	complement(1411439..1411957)	Ehrlichia ruminantium str. Welgevonden	3233234
YP_180685.1	CDS	dacF	NC_005295.2	1413494	1414366	D	probable dacF | probable exported D-alanyl-D-alanine carboxypeptidase | len: 290 aa | Similar to many carboxypeptidases e.g. DACC_ECOLI P08506 Penicillin-binding protein 6 precursor (400 aa) from Escherichia coli, fasta scores: E(): 2.6e-21, 33.603% identity in 247 aa overlap | Contains Pfam match to entry PF00768 Peptidase_S11, D-alanyl-D-alanine carboxypeptidase | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.985) with cleavage site probability 0.972 between residues 26 and 27; penicillin-binding protein dacF precursor	1413494..1414366	Ehrlichia ruminantium str. Welgevonden	3233484
YP_180686.1	CDS	Erum8230	NC_005295.2	1415176	1416384	R	probable integral membrane protein | len: 402 aa | Similar to the C-terminus of many e.g. DSBD_ECOLI P36655 Thiol:disulfide interchange protein dsbD precursor (565 aa) from Escherichia coli, fasta scores: E(): 2.9e-11, 23.980% identity in 392 aa overlap | Contains 8 probable transmembrane helices predicted by TMHMM2.0 at aa 7-29, 49-71, 92-114, 134-156, 163-185, 205-222, 229-246 and 256-275; thiol:disulfide interchange protein dsbD precursor	complement(1415176..1416384)	Ehrlichia ruminantium str. Welgevonden	3233235
YP_180687.1	CDS	Erum8240	NC_005295.2	1417192	1417473	R	conserved hypothetical protein | len: 93 aa | Similar to several from Alphaproteobacteria e.g. Q8UEH8 Hypothetical protein Atu1779 (106 aa) from Agrobacterium tumefaciens, fasta scores: E(): 7.5e-08, 40.244% identity in 82 aa overlap | Contains Pfam match to entry PF03937 TPR_div1, TPR repeat region; hypothetical protein	complement(1417192..1417473)	Ehrlichia ruminantium str. Welgevonden	3233236
YP_180688.1	CDS	Erum8250	NC_005295.2	1417593	1418732	D	probable membrane-associated zinc metalloprotease | len: 379 aa | Similar to many e.g. Y161_RICPR Q9ZE02 Hypothetical zinc metalloprotease (359 aa) from Rickettsia prowazekii, fasta scores: E(): 2.5e-42, 37.088% identity in 364 aa overlap and ECFE_ECOLI P37764 Protease ecfE (450 aa) from Escherichia coli, fasta scores: E(): 8.1e-12, 30.000% identity in 450 aa overlap | Contains Pfam match to entry PF02163 Peptidase_M50, Peptidase family M50 and PF00595 PDZ, PDZ domain (Also known as DHR or GLGF) | Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature | Contains 4 probable transmembrane helices predicted by TMHMM2.0 at aa 7-29, 119-141, 305-327 and 353-372; metalloprotease	1417593..1418732	Ehrlichia ruminantium str. Welgevonden	3233237
YP_180689.1	CDS	Erum8260	NC_005295.2	1418737	1421052	D	probable outer membrane protein | len: 771 aa | Similar to many e.g. D153_HAEIN O32629 Protective surface antigen D15 precursor (793 aa) from Haemophilus influenzae, fasta scores: E(): 2e-27, 22.917% identity in 816 aa overlap | Contains Pfam match to entry PF01103 Bac_surface_Ag, Surface antigen | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.605 between residues 18 and 19; hypothetical protein	1418737..1421052	Ehrlichia ruminantium str. Welgevonden	3233238
YP_180690.1	CDS	Erum8270	NC_005295.2	1421065	1421613	D	probable outer membrane protein | len: 182 aa | Similar to three hypothetical proteins from Rickettsia species e.g. Q92IR8 Hypothetical protein RC0352 (184 aa) from Rickettsia conorii, fasta scores: E(): 2.4e-10, 35.000% identity in 180 aa overlap | Contains Pfam match to entry PF03938 OmpH, Outer membrane protein (OmpH-like) | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.660 between residues 22 and 23; hypothetical protein	1421065..1421613	Ehrlichia ruminantium str. Welgevonden	3233239
YP_180691.1	CDS	fabZ	NC_005295.2	1421623	1422060	D	in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase	1421623..1422060	Ehrlichia ruminantium str. Welgevonden	3233319
YP_180692.1	CDS	purH	NC_005295.2	1422102	1423616	D	purH | bifunctional purine biosynthesis protein PurH | len: 504 aa | Highly similar to many e.g. PUR9_BACSU P12048 Bifunctional purine biosynthesis protein purH (512 aa) from Bacillus subtilis, fasta scores: E(): 1.5e-81, 45.349% identity in 516 aa overlap | Contains Pfam match to entry PF02142 MGS, MGS-like domain and PF01808 AICARFT_IMPCHas, AICARFT/IMPCHase bienzyme; bifunctional phospho ribosylaminoimidazole carboxamide formyltransferase/IMP cyclohydrolase	1422102..1423616	Ehrlichia ruminantium str. Welgevonden	3232634
YP_180693.1	CDS	pgsA	NC_005295.2	1424126	1424683	R	probable pgsA | probable CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase | Similar to many e.g. PGSA_ECOLI P06978 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (181 aa) from Escherichia coli, fasta scores: E(): 3.6e-18, 37.430% identity in 179 aa overlap | Contains Pfam match to entry PF01066 CDP-OH_P_transf, CDP-alcohol phosphatidyltransferase | Contains PS00379 CDP-alcohol phosphatidyltransferases signature | Contains 5 probable transmembrane helices predicted by TMHMM2.0 at aa 13-30, 37-59, 82-104, 124-146 and 150-172; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase	complement(1424126..1424683)	Ehrlichia ruminantium str. Welgevonden	3232577
YP_180694.1	CDS	Erum8310	NC_005295.2	1425031	1426332	D	probable integral membrane protein | len: 433 aa | Similar to two hypothetical membrane proteins e.g. Y382_RICPR Q9ZDE9 Hypothetical protein RP382 (510 aa) from Rickettsia prowazekii, fasta scores: E(): 8.2e-05, 32.525% identity in 495 aa overlap | Contains Pfam match to entry PF00115 COX1, Cytochrome C and Quinol oxidase polypeptide I | Contains 12 probable transmembrane helices predicted by TMHMM2.0 at aa 16-38, 58-80, 93-112, 127-146, 159-181, 196-218, 230-252, 267-286, 298-320, 330-352, 365-387 and 402-424; hypothetical protein	1425031..1426332	Ehrlichia ruminantium str. Welgevonden	3233240
YP_180695.1	CDS	Erum8320	NC_005295.2	1427121	1427762	R	possible Surf1-like protein | len: 213 aa | Weakly similar to several e.g. Q9ZCJ8 RP733 SURF1-like protein (244 aa) from Rickettsia prowazekii, fasta scores: E(): 1.1e-08, 29.956% identity in 227 aa overlap | Contains 2 probable transmembrane helices predicted by TMHMM2.0 at aa 7-26 and 189-208; Surf1-like protein	complement(1427121..1427762)	Ehrlichia ruminantium str. Welgevonden	3233241
YP_180696.1	CDS	Erum8330	NC_005295.2	1428185	1430014	D	conserved hypothetical protein | len: 609 aa | Similar to many e.g. Q9ZCY8 Hypothetical protein RP563 (588 aa) from Rickettsia prowazekii, fasta scores: E(): 3.2e-32, 28.162% identity in 593 aa overlap | Contains 10 Pfam matches to entry PF00805 Pentapeptide, Pentapeptide repeats (8 copies) | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.965) with cleavage site probability 0.963 between residues 27 and 28; hypothetical protein	1428185..1430014	Ehrlichia ruminantium str. Welgevonden	3233242
YP_180697.1	CDS	Erum8340	NC_005295.2	1431111	1432979	R	unknown | Similar to Q93FT8 Hypothetical 46.0 kDa protein (Fragment) (409 aa) from Ehrlichia ruminantium (Highway), fasta scores: E(): 7.2e-08, 26.160% identity in 474 aa overlap | Similar to Erum0690, Erum8170, Erum8190; hypothetical protein	complement(1431111..1432979)	Ehrlichia ruminantium str. Welgevonden	3233243
YP_180698.1	CDS	Erum8350	NC_005295.2	1434102	1435361	R	unknown | len: 419 aa | Identical to Q93FT5 Hypothetical AraM protein (Fragment) from Ehrlichia ruminantium (Highway) (184 aa), fasta scores: E(): 6.2e-68, 100.000% identity in 184 aa overlap. Similar to ARAM_BACSU P94527 Arabinose operon protein araM (394 aa) from Bacillus subtilis, fasta scores: E(): 1.9e-18, 29.966% identity in 297 aa overlap. Similar to many uncharacterized proteins that have been termed Glycerol-1-phosphate dehydrogenases e.g. P58460 Glycerol-1-phosphate dehydrogenase [NAD(P)] from Sulfolobus tokodaii (350 aa), fasta scores: E(): 1.9e-18, 29.966% identity in 297 aa overlap; glycerol-1-phosphate dehydrogenase (NAD(P))	complement(1434102..1435361)	Ehrlichia ruminantium str. Welgevonden	3233244
YP_180699.1	CDS	atpB	NC_005295.2	1436297	1437028	D	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; ATP synthase F0F1 subunit A	1436297..1437028	Ehrlichia ruminantium str. Welgevonden	3233283
YP_180700.1	CDS	atpE	NC_005295.2	1437098	1437319	D	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; ATP synthase F0F1 subunit C	1437098..1437319	Ehrlichia ruminantium str. Welgevonden	3233285
YP_180701.1	CDS	atpF	NC_005295.2	1437329	1437832	D	probable atpF | probable ATP synthase B subunit | len: 167 aa | Identical to Q93FT2 Hypothetical ATP synthase B chain (Fragment) (87 aa) from Ehrlichia ruminantium (Highway), fasta scores: E(): 1.5e-26, 100.000% identity in 87 aa overlap. Similar to many that have been termed either ATP synthase B or B' chain, e.g. ATPX_RHORU P15015 ATP synthase B' chain (161 aa) from Rhodospirillum rubrum, fasta scores: E(): 0.087, 18.056% identity in 144 aa overlap | Contains Pfam match to entry PF00430 ATP-synt_B, ATP synthase B/B' CF(0) | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 15-35; ATP synthase subunit B	1437329..1437832	Ehrlichia ruminantium str. Welgevonden	3233472
YP_180702.1	CDS	Erum8390	NC_005295.2	1437829	1438320	D	probable membrane protein | len: 163 aa | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 4-23; hypothetical protein	1437829..1438320	Ehrlichia ruminantium str. Welgevonden	3233245
YP_180703.1	CDS	ftsA	NC_005295.2	1438322	1439581	R	ftsA | cell division protein FtsA | len: 419 aa | Similar to many e.g. FTSA_ECOLI P06137 Cell division protein ftsA (420 aa) from Escherichia coli, fasta scores: E(): 1.7e-22, 29.288% identity in 379 aa overlap| Contains 2 Pfam matches to entry PF02491 FtsA, Cell division protein FtsA; cell division protein ftsa	complement(1438322..1439581)	Ehrlichia ruminantium str. Welgevonden	3233327
YP_180704.1	CDS	trkH	NC_005295.2	1440605	1442056	R	trkH | Trk system potassium uptake protein | len: 483 aa | Similar to many e.g. TRKH_ECOLI P21166 Trk system potassium uptake protein (483 aa) from Escherichia coli, fasta scores: E(): 1.7e-42, 32.640% identity in 481 aa overlap | Contains Pfam match to entry PF02386 TrkH, Cation transport protein | Contains 12 probable transmembrane helices predicted by TMHMM2.0 at aa 7-29, 34-56, 68-90, 124-146, 178-200, 231-253, 266-286, 296-318, 325-347, 386-408, 415-437 and 452-474; Trk system potassium uptake protein trkH	complement(1440605..1442056)	Ehrlichia ruminantium str. Welgevonden	3232745
YP_180705.1	CDS	Erum8420	NC_005295.2	1443445	1444773	D	conserved hypothetical protein | len: 442 aa | Similar to several rickettsial hypothetical proteins e.g. Y042_RICPR Q9ZEA3 Hypothetical protein RP042 (430 aa) from Rickettsia prowazekii, fasta scores: E(): 1.4e-25, 30.216% identity in 417 aa overlap. Partially similar to many proteins that have been termed  cell cycle proteins e.g. MESJ_ECOLI P52097  cell cycle protein mesJ (432 aa) from Escherichia coli, fasta scores: E(): 4e-10, 31.461% identity in 178 aa overlap | Contains Pfam match to entry PF01171 ATP_bind3, PP-loop family; hypothetical protein	1443445..1444773	Ehrlichia ruminantium str. Welgevonden	3233246
YP_180706.1	CDS	ftsH	NC_005295.2	1444770	1446605	D	ftsH | cell division protein FtsH | len: 611 aa | Highly similar to many e.g. FTSH_ECOLI P28691 Cell division protein ftsH (644 aa) from Escherichia coli, fasta scores: E(): 7.7e-110, 54.908% identity in 601 aa overlap | Contains Pfam match to entry PF06480 FtsH Extracellular, PF00004 AAA, ATPase family associated with various cellular activities (AAA) and PF01434 Peptidase_M41, Peptidase family M41 | Contains PS00017 ATP/GTP-binding site motif A (P-loop) and PS00674 AAA-protein family signature | Contains 2 probable transmembrane helices predicted by TMHMM2.0 at aa 4-26 and 100-122. The initial transmembrane helix could represent a possible N-terminal signal sequence.; cell division protein ftsh-like protein	1444770..1446605	Ehrlichia ruminantium str. Welgevonden	3233328
YP_180707.1	CDS	lgt	NC_005295.2	1448762	1449541	R	transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase	complement(1448762..1449541)	Ehrlichia ruminantium str. Welgevonden	3233379
YP_180708.1	CDS	Erum8450	NC_005295.2	1452058	1453740	R	probable integral membrane protein | len: 560 aa | Contains 5 probable transmembrane helices predicted by TMHMM2.0 at aa 195-217, 311-333, 343-365, 372-393 and 403-425 | C-terminus ends within a tandem repeat, 243 bp repeated 5.2 times; hypothetical protein	complement(1452058..1453740)	Ehrlichia ruminantium str. Welgevonden	3233247
YP_180709.1	CDS	Erum8460	NC_005295.2	1453806	1453976	R	unknown | len: 56 aa; hypothetical protein	complement(1453806..1453976)	Ehrlichia ruminantium str. Welgevonden	3233248
YP_180710.1	CDS	secD	NC_005295.2	1454573	1456090	R	part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD	complement(1454573..1456090)	Ehrlichia ruminantium str. Welgevonden	3232604
YP_180711.1	CDS	thiF	NC_005295.2	1456497	1457279	R	probable thiF | probable adenylyltransferase ThiF | len: 260 aa | Similar to several e.g. THIF_ECOLI P30138 Adenylyltransferase thiF (251 aa) from Escherichia coli, fasta scores: E(): 1.5e-32, 37.097% identity in 248 aa overlap | Contains Pfam match to entry PF00899 ThiF, ThiF family and PF05237 MoeZ_MoeB, MoeZ/MoeB domain | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 27-49. The transmembrane helix could represent a possible N-terminal signal sequence.; adenylyltransferase	complement(1456497..1457279)	Ehrlichia ruminantium str. Welgevonden	3232611
YP_180712.1	CDS	pyrE	NC_005295.2	1457283	1457882	R	involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase	complement(1457283..1457882)	Ehrlichia ruminantium str. Welgevonden	3232586
YP_180713.1	CDS	recA	NC_005295.2	1458249	1459322	R	catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A	complement(1458249..1459322)	Ehrlichia ruminantium str. Welgevonden	3232647
YP_180714.1	CDS	Erum8510	NC_005295.2	1460802	1461473	R	probable membrane protein | len: 223 aa | Similar to many e.g. BIOD_BACSU Dethiobiotin synthetase (231 aa) from Bacillus subtilis, fasta scores: E(): 1.1e-09, 27.419% identity in 186 aa overlap. However Erum8510 lacks the ATP binding domain characteristic of dethiobiotin synthetases | Contains 1 probable transmembrane helix predicted by TMHMM2.0 at aa 4-26; dethiobiotin synthetase	complement(1460802..1461473)	Ehrlichia ruminantium str. Welgevonden	3233249
YP_180715.1	CDS	ftsY	NC_005295.2	1461556	1462485	D	probable ftsY | probable cell division protein FtsY | len: 309 aa | Similar to many proteins of similar length that have been termed FtsY e.g. FTSY_RICPR Cell division protein ftsY homolog (303 aa) from Rickettsia prowazekii, fasta scores: E(): 6.1e-51, 47.667% identity in 300 aa overlap. Lacks the initial 190 residues of FtsY from E. coli, but in the overlapping region it is similar to FTSY_ECOLI Cell division protein ftsY (497 aa) from Escherichia coli, fasta scores: E(): 4.7e-49, 45.752% identity in 306 aa overlap | Contains Pfam match to entry PF02881 SRP54_N, SRP54-type protein, helical bundle domain and PF00448 SRP54, SRP54-type protein, GTPase domain | Contains PS00017 ATP/GTP-binding site motif A (P-loop) | Similar to Erum5430; cell division protein ftsY-like protein	1461556..1462485	Ehrlichia ruminantium str. Welgevonden	3233510
YP_180716.1	CDS	icd	NC_005295.2	1464098	1465549	R	catalyzes the formation of 2-oxoglutarate from isocitrate; isocitrate dehydrogenase	complement(1464098..1465549)	Ehrlichia ruminantium str. Welgevonden	3233368
YP_180717.1	CDS	recJ	NC_005295.2	1467707	1469464	D	probable recJ | probable single-stranded-DNA-specific exonuclease RecJ | len: 585 aa | Similar to many e.g. RECJ_ECOLI Single-stranded-DNA-specific exonuclease recJ (577 aa) from Escherichia coli, fasta scores: E(): 4.8e-34, 32.200% identity in 559 aa overlap | Contains Pfam match to entry PF01368 DHH, DHH family and PF02272 DHHA1, DHHA1 domain; single-stranded-DNA-specific exonuclease recJ	1467707..1469464	Ehrlichia ruminantium str. Welgevonden	3232591
YP_180718.1	CDS	Erum8560	NC_005295.2	1470596	1471789	D	probable nucleic acid independent RNA polymerase | len: 397 aa | Similar to many uncharacterized bacterial proteins e.g. Q9ZEC8 POLY(A) polymerase (PCNB) (387 aa) from Rickettsia prowazekii, fasta scores: E(): 3.9e-41, 36.559% identity in 372 aa overlap. Also similar to two eukaryotic proteins e.g. CCA1_HUMAN tRNA-nucleotidyltransferase 1, mitochondrial precursor (434 aa) from Homo sapiens, fasta scores: E(): 9.5e-40, 34.518% identity in 394 aa overlap | Contains Pfam match to entry PF01743 PolyA_pol, Poly A polymerase family; poly(A) polymerase	1470596..1471789	Ehrlichia ruminantium str. Welgevonden	3233251
YP_180719.1	CDS	ndk	NC_005295.2	1473040	1473471	R	catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase	complement(1473040..1473471)	Ehrlichia ruminantium str. Welgevonden	3233415
YP_180720.1	CDS	Erum8580	NC_005295.2	1473711	1474316	D	possible transcriptional regulator | len: 201 aa | Similar to several uncharacterized proteins e.g. O54360 Hypothetical transcriptional regulator (213 aa) from Ehrlichia chaffeensis, fasta scores: E(): 6.5e-53, 75.000% identity in 212 aa overlap | Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix | Contains predicted helix-turn-helix motif; transcriptional regulator	1473711..1474316	Ehrlichia ruminantium str. Welgevonden	3233252
YP_180721.1	CDS	Erum8590	NC_005295.2	1474595	1475524	D	map1-14 | probable outer membrane protein MAP1-14 | len: 309 aa | Similar to many e.g. Q9ACJ6 Major outer membrane protein OMP-1M (298 aa) from Ehrlichia chaffeensis, fasta scores: E(): 2.5e-25, 60.897% identity in 312 aa overlap | Contains Pfam match to entry PF01617 Surface_Ag_2, Surface antigen | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 1.000 with cleavage site probability 0.981 between residues 28 and 29 | Similar to Erum8670, Erum8720, Erum8660, Erum8650, Erum8700, Erum8750, Erum8710, Erum8730, Erum8640, Erum8630, Erum8600, Erum8740, Erum8680, Erum8620; Map1-related protein	1474595..1475524	Ehrlichia ruminantium str. Welgevonden	3233396
YP_180722.1	CDS	Erum8600	NC_005295.2	1476408	1477292	D	map1-13 | probable outer membrane protein MAP1-13 | len: 294 aa | Similar to many e.g. Q9L6Z5 P28-1 (271 aa) from Ehrlichia chaffeensis, fasta scores: E(): 7.8e-42, 49.653% identity in 288 aa overlap | Contains Pfam match to entry PF01617 Surface_Ag_2, Surface antigen | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.982) with cleavage site probability 0.477 between residues 21 and 22 | Similar to Erum8650, Erum8700, Erum8680, Erum8720, Erum8670, Erum8750, Erum8710, Erum8660, Erum8730, Erum8630, Erum8740, Erum8640, Erum8620, Erum8590; Map1-related protein	1476408..1477292	Ehrlichia ruminantium str. Welgevonden	3233395
YP_180723.1	CDS	Erum8610	NC_005295.2	1477381	1478091	D	probable exported protein | len: 236 aa | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.558 between residues 25 and 26 | Termed un1 (UNKNOWN 1) in van Heerden et al. (2004) Gene 330: 159-168; hypothetical protein	1477381..1478091	Ehrlichia ruminantium str. Welgevonden	3233253
YP_180724.1	CDS	Erum8620	NC_005295.2	1478088	1478915	D	map1-12 | probable outer membrane protein MAP1-12 | len: 275 aa | Similar to many e.g. Q9L6Y6 P28-8 (Major outer membrane protein OMP-1X) (275 aa) from Ehrlichia chaffeensis, fasta scores: E(): 1.5e-28, 34.035% identity in 285 aa overlap | Contains Pfam match to entry PF01617 Surface_Ag_2, Surface antigen | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.850 between residues 23 and 24 | Similar to Erum8660, Erum8670, Erum8730, Erum8740, Erum8640, Erum8720, Erum8700, Erum8650, Erum8680, Erum8710, Erum8600, Erum8630, Erum8750, Erum8590; Map1-related protein	1478088..1478915	Ehrlichia ruminantium str. Welgevonden	3233394
YP_180725.1	CDS	Erum8630	NC_005295.2	1478931	1479812	D	map1-11 | probable outer membrane protein MAP1-11 | len: 293 aa | Similar to many e.g. Q9ADV9 Major outer membrane protein P30-12 (289 aa) from Ehrlichia canis, fasta scores: E(): 2.2e-33, 41.333% identity in 300 aa overlap | Contains Pfam match to entry PF01617 Surface_Ag_2, Surface antigen | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.822) with cleavage site probability 0.750 between residues 23 and 24 | Similar to Erum8650, Erum8700, Erum8710, Erum8720, Erum8680, Erum8670, Erum8660, Erum8740, Erum8730, Erum8600, Erum8750, Erum8640, Erum8590, Erum8620; Map1-related protein	1478931..1479812	Ehrlichia ruminantium str. Welgevonden	3233393
YP_180726.1	CDS	Erum8640	NC_005295.2	1479840	1480613	D	map1-10 | probable outer membrane protein MAP1-10 | len: 257 aa | Similar to many e.g. Q9L6Z1 P28-4 (Major outer membrane protein OMP-1T) (272 aa) from Ehrlichia chaffeensis, fasta scores: E(): 1.7e-49, 45.985% identity in 274 aa overlap | Contains Pfam match to entry PF01617 Surface_Ag_2, Surface antigen | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.978) with cleavage site probability 0.757 between residues 27 and 28 | Similar to Erum8660, Erum8730, Erum8670, Erum8650, Erum8710, Erum8720, Erum8740, Erum8700, Erum8620, Erum8750, Erum8630, Erum8680, Erum8590, Erum8600; Map1-related protein	1479840..1480613	Ehrlichia ruminantium str. Welgevonden	3233392
YP_180727.1	CDS	Erum8650	NC_005295.2	1480630	1481499	D	map1-9 | probable outer membrane protein MAP1-9 | len: 289 aa | Similar to many e.g. Q9L6Z0 P28-5 (Major outer membrane proten OMP-1U) (295 aa) from Ehrlichia chaffeensis, fasta scores: E(): 1.6e-61, 51.186% identity in 295 aa overlap | Contains Pfam match to entry PF01617 Surface_Ag_2, Surface antigen | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.977 between residues 26 and 27 | Similar to Erum8700, Erum8720, Erum8710, Erum8680, Erum8630, Erum8660, Erum8600, Erum8670, Erum8750, Erum8640, Erum8730, Erum8740, Erum8590, Erum8620, Erum8690; Map1-related protein	1480630..1481499	Ehrlichia ruminantium str. Welgevonden	3233404
YP_180728.1	CDS	Erum8660	NC_005295.2	1481525	1482373	D	map1-8 | probable outer membrane protein MAP1-8 | len: 282 aa | Similar to many e.g. Q9ACJ2 Major outer membrane protein OMP-1V (279 aa) from Ehrlichia chaffeensis, fasta scores: E(): 9.8e-66, 59.155% identity in 284 aa overlap | Contains Pfam match to entry PF01617 Surface_Ag_2, Surface antigen | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.531 between residues 29 and 30 | Similar to Erum8670, Erum8730, Erum8740, Erum8750, Erum8620, Erum8640, Erum8650, Erum8720, Erum8710, Erum8700, Erum8680, Erum8630, Erum8600, Erum8590, Erum8690; Map1-related protein	1481525..1482373	Ehrlichia ruminantium str. Welgevonden	3233403
YP_180729.1	CDS	Erum8670	NC_005295.2	1482384	1483235	D	map1-7 | probable outer membrane protein MAP1-7 | len: 283 aa | Similar to many e.g. Q9ADV8 Major outer membrane protein P30-11 (279 aa) from Ehrlichia canis, fasta scores: E(): 5.3e-57, 53.381% identity in 281 aa overlap | Contains Pfam match to entry PF01617 Surface_Ag_2, Surface antigen | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.991 between residues 27 and 28 | Similar to Erum8660, Erum8730, Erum8720, Erum8750, Erum8700, Erum8680, Erum8740, Erum8620, Erum8710, Erum8650, Erum8630, Erum8640, Erum8600, Erum8590; Map1-related protein	1482384..1483235	Ehrlichia ruminantium str. Welgevonden	3233402
YP_180730.1	CDS	Erum8680	NC_005295.2	1483255	1484142	D	map1-6 | probable outer membrane protein MAP1-6 | len: 295 aa | Similar to many e.g. Q9ACJ0 Major outer membrane protein OMP-1S (291 aa) from Ehrlichia chaffeensis, fasta scores: E(): 1.8e-43, 45.574% identity in 305 aa overlap | Contains Pfam match to entry PF01617 Surface_Ag_2, Surface antigen | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.990 between residues 27 and 28 | Similar to Erum8700, Erum8650, Erum8710, Erum8720, Erum8670, Erum8740, Erum8630, Erum8750, Erum8600, Erum8660, Erum8730, Erum8620, Erum8640, Erum8590; Map1-related protein	1483255..1484142	Ehrlichia ruminantium str. Welgevonden	3233401
YP_180731.1	CDS	Erum8690	NC_005295.2	1484151	1484768	D	map1-5 | possible truncated outer membrane protein MAP1-5 | len: 205 aa | Weakly similar to the C-terminus of several e.g. Q9F477 P28-1 (Major outer membrane protein P30-5) (293 aa) from Ehrlichia canis, fasta scores: E(): 2.6e-08, 29.940% identity in 167 aa overlap | Note that there is no predicted signal peptide and the Pfam match PF01617 Surface_Ag_2 characteristic of the other map1-multigene family members is absent. | Similar to Erum8700, Erum8720, Erum8710, Erum8650, Erum8660; Map1-related protein	1484151..1484768	Ehrlichia ruminantium str. Welgevonden	3233400
YP_180732.1	CDS	Erum8700	NC_005295.2	1484808	1485701	D	map1-4 | probable outer membrane protein MAP1-4 | len: 297 aa | Similar to many e.g. Q9F477 P28-1 (Major outer membrane protein P30-5) (293 aa) from Ehrlichia canis, fasta scores: E(): 5.4e-59, 53.199% identity in 297 aa overlap | Contains Pfam match to entry PF01617 Surface_Ag_2, Surface antigen | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 28 and 29 | Similar to Erum8650, Erum8710, Erum8720, Erum8680, Erum8630, Erum8670, Erum8660, Erum8740, Erum8600, Erum8750, Erum8730, Erum8640, Erum8620, Erum8590, Erum8690; Map1-related protein	1484808..1485701	Ehrlichia ruminantium str. Welgevonden	3233399
YP_180733.1	CDS	Erum8710	NC_005295.2	1485722	1486669	D	map1-3 | probable outer membrane protein MAP1-3 | len: 315 aa | Similar to many e.g. Q9F477 P28-1 (Major outer membrane protein P30-5) (293 aa) from Ehrlichia canis, fasta scores: E(): 5.1e-53, 58.466% identity in 313 aa overlap | Contains Pfam match to entry PF01617 Surface_Ag_2, Surface antigen | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.987 between residues 24 and 25 | Similar to Erum8720, Erum8700, Erum8650, Erum8680, Erum8630, Erum8660, Erum8670, Erum8750, Erum8600, Erum8730, Erum8640, Erum8740, Erum8590, Erum8620, Erum8690; Map1-related protein	1485722..1486669	Ehrlichia ruminantium str. Welgevonden	3233398
YP_180734.1	CDS	Erum8720	NC_005295.2	1486693	1487613	D	map1-2 | probable outer membrane protein MAP1-2 | len: 306 aa | Similar to many e.g. Q9L6Y3 P28-11 (Major outer membrane protein OMP-1H) (298 aa) from Ehrlichia chaffeensis, fasta scores: E(): 4.7e-63, 54.045% identity in 309 aa overlap | Contains Pfam match to entry PF01617 Surface_Ag_2, Surface antigen | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.994) with cleavage site probability 0.897 between residues 24 and 25 | Similar to Erum8710, Erum8700, Erum8650, Erum8670, Erum8680, Erum8660, Erum8630, Erum8740, Erum8600, Erum8750, Erum8730, Erum8640, Erum8590, Erum8620, Erum8690; Map1-related protein	1486693..1487613	Ehrlichia ruminantium str. Welgevonden	3233397
YP_180735.1	CDS	Erum8730	NC_005295.2	1489006	1489854	D	map1-1 | probable outer membrane protein MAP1-1 | len: 282 aa | Previously identified in E. ruminantium, Q9WW41 Major antigenic protein 1 like protein (282 aa) from Ehrlichia ruminantium (Crystal Springs and Highway), fasta scores: E(): 1e-118, 100.000% identity in 282 aa overlap | Contains Pfam match to entry PF01617 Surface_Ag_2, Surface antigen | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.993 between residues 25 and 26 | Similar to Erum8660, Erum8740, Erum8670, Erum8750, Erum8640, Erum8620, Erum8680, Erum8710, Erum8720, Erum8600, Erum8650, Erum8700, Erum8630, Erum8590; Map1-related protein	1489006..1489854	Ehrlichia ruminantium str. Welgevonden	3233391
YP_180736.1	CDS	map1	NC_005295.2	1490227	1491099	D	map1 | major antigenic protein MAP1 | len: 290 aa | Previously characterized in E. ruminantium, Q46324 Major antigenic surface protein (290 aa) from Ehrlichia ruminantium (Welgevonden), fasta scores: E(): 3.9e-124, 100.000% identity in 290 aa overlap | Contains Pfam match to entry PF01617 Surface_Ag_2, Surface antigen | Contains signal peptide predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.994 between residues 25 and 26 | Similar to Erum8730, Erum8660, Erum8680, Erum8670, Erum8700, Erum8750, Erum8720, Erum8630, Erum8620, Erum8650, Erum8640, Erum8600, Erum8710, Erum8590; hypothetical protein	1490227..1491099	Ehrlichia ruminantium str. Welgevonden	3233389
YP_180737.1	CDS	Erum8750	NC_005295.2	1492706	1493563	R	map1+1 | probable outer membrane protein MAP1+1 | len: 285 aa | Similar to many e.g. O69197 P28-20 precursor (Major outer membrane protein P28-1) (271 aa) from Ehrlichia chaffeensis, fasta scores: E(): 5.7e-58, 59.075% identity in 281 aa overlap | Note that there is no predicted signal peptide characteristic of the other map1-multigene family members. | Contains Pfam match to entry PF01617 Surface_Ag_2, Surface antigen | Similar to Erum8670, Erum8730, Erum8660, Erum8740, Erum8650, Erum8680, Erum8710, Erum8700, Erum8720, Erum8600, Erum8630, Erum8640, Erum8590, Erum8620; Map1-related protein	complement(1492706..1493563)	Ehrlichia ruminantium str. Welgevonden	3233390
YP_180738.1	CDS	Erum8760	NC_005295.2	1494051	1494386	D	unknown | len: 111 aa | Termed un2 (UNKNOWN 2) in van Heerden et al. (2004) Gene 330: 159-168; hypothetical protein	1494051..1494386	Ehrlichia ruminantium str. Welgevonden	3233254
YP_180739.1	CDS	Erum8770	NC_005295.2	1495468	1496001	D	unknown | len: 177 aa | Weakly similar to two other Ehrlichial proteins e.g. Q9ACI7 Hypothetical protein (142 aa) from Ehrlichia chaffeensis, fasta scores: E(): 9.3e-12, 40.816% identity in 147 aa overlap | Contains a tandem repeat, 24 bp repeated 6.3 times (or 15 bp repeated 7.7 times, or 9 bp repeated 11.6 times) | Termed un3 (UNKNOWN 3) in van Heerden et al. (2004) Gene 330: 159-168; hypothetical protein	1495468..1496001	Ehrlichia ruminantium str. Welgevonden	3233255
YP_180740.1	CDS	secA	NC_005295.2	1496326	1498938	D	functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA	1496326..1498938	Ehrlichia ruminantium str. Welgevonden	3232722
YP_180741.1	CDS	Erum8790	NC_005295.2	1500158	1500589	R	unknown | len: 143 aa; hypothetical protein	complement(1500158..1500589)	Ehrlichia ruminantium str. Welgevonden	3233256
YP_180742.1	CDS	ftsZ	NC_005295.2	1502117	1503385	D	GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ	1502117..1503385	Ehrlichia ruminantium str. Welgevonden	3233329
YP_180743.1	CDS	Erum8810	NC_005295.2	1503392	1503799	D	conserved hypothetical protein | len: 135 aa | Similar to several uncharacterized proteins e.g. Q8YJB4 Hypothetical protein BMEI0172 (142 aa) from Brucella melitensis, fasta scores: E(): 7.2e-13, 37.984% identity in 129 aa overlap | Contains Pfam match to entry PF04543 DUF589, Family of unknown function (DUF589); hypothetical protein	1503392..1503799	Ehrlichia ruminantium str. Welgevonden	3233257
YP_180744.1	CDS	Erum8820	NC_005295.2	1503796	1504269	D	conserved hypothetical protein | len: 157 aa | Similar to several e.g. YBEY_ECOL6 Hypothetical UPF0054 protein ybeY (155 aa) from Escherichia coli, fasta scores: E(): 1e-09, 34.211% identity in 114 aa overlap | Contains Pfam match to entry PF02130 UPF0054, Uncharacterized protein family UPF0054; hypothetical protein	1503796..1504269	Ehrlichia ruminantium str. Welgevonden	3233258
YP_180745.1	CDS	parA	NC_005295.2	1504498	1505265	D	parA | chromosome partitioning protein ParA | len: 255 aa | Highly similar to many e.g. PARA_CAUCR Chromosome partitioning protein parA (267 aa) from Caulobacter crescentus, fasta scores: E(): 4e-60, 56.471% identity in 255 aa overlap | Contains Pfam match to entry PF00991 ParA, ParA family ATPase; sporulation initiation inhibitor protein soj	1504498..1505265	Ehrlichia ruminantium str. Welgevonden	3233430
YP_180746.1	CDS	parB	NC_005295.2	1505276	1506145	D	parB | chromosome partitioning protein ParB | len: 289 aa | Similar to many e.g. PARB_CAUCR Chromosome partitioning protein parB (294 aa) from Caulobacter crescentus, fasta scores: E(): 1.5e-32, 37.631% identity in 287 aa overlap | Contains Pfam match to entry PF02195 ParBc, ParB-like nuclease domain | Contains predicted helix-turn-helix motif; chromosome partitioning protein parB	1505276..1506145	Ehrlichia ruminantium str. Welgevonden	3233431
YP_180747.1	CDS	rimM	NC_005295.2	1506502	1507020	D	Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM	1506502..1507020	Ehrlichia ruminantium str. Welgevonden	3232595
YP_180748.1	CDS	trmD	NC_005295.2	1507010	1507717	D	methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase	1507010..1507717	Ehrlichia ruminantium str. Welgevonden	3232746
YP_180749.1	CDS	rplS	NC_005295.2	1507710	1508087	D	this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19	1507710..1508087	Ehrlichia ruminantium str. Welgevonden	3232678
YP_180750.1	CDS	Erum8880	NC_005295.2	1509098	1509598	R	unknown | len: 166 aa | Similar to many hypothetical proteins e.g. YGAD_ECOLI Protein ygaD (165 aa) from Escherichia coli, fasta scores: E(): 3.8e-13, 32.727% identity in 165 aa overlap | Contains Pfam match to entry PF02464 CinA, Competence-damaged protein; hypothetical protein	complement(1509098..1509598)	Ehrlichia ruminantium str. Welgevonden	3233259
YP_180751.1	CDS	thrS	NC_005295.2	1509872	1511773	D	catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase	1509872..1511773	Ehrlichia ruminantium str. Welgevonden	3232739
YP_180752.1	CDS	infC	NC_005295.2	1511800	1512321	D	IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3	1511800..1512321	Ehrlichia ruminantium str. Welgevonden	3233371
YP_180753.1	CDS	Erum8910	NC_005295.2	1513793	1514245	R	conserved hypothetical protein | len: 150 aa | Similar to many e.g. Y013_RICCN Hypothetical protein RC0013 (175 aa) from Rickettsia conorii, fasta scores: E(): 2.3e-11, 35.433% identity in 127 aa overlap | Contains Pfam match to entry PF02367 UPF0079, Uncharacterised P-loop hydrolase UPF0079 | Contains PS00017 ATP/GTP-binding site motif A (P-loop); hypothetical protein	complement(1513793..1514245)	Ehrlichia ruminantium str. Welgevonden	3233260
YP_180754.1	CDS	Erum8920	NC_005295.2	1514291	1514995	R	probable integral membrane protein | len: 234 aa | Similar to many e.g. YBHL_ECOLI Hypothetical protein ybhL (234 aa) from Escherichia coli, fasta scores: E(): 5.4e-27, 38.356% identity in 219 aa overlap | Contains Pfam match to entry PF01027 UPF0005, Uncharacterised protein family UPF0005 | Contains 6 probable transmembrane helices predicted by TMHMM2.0 at aa 21-43, 58-80, 85-107, 139-161, 168-187 and 207-229; hypothetical protein	complement(1514291..1514995)	Ehrlichia ruminantium str. Welgevonden	3233261
YP_180755.1	CDS	Erum8930	NC_005295.2	1515100	1516329	R	probable integral membrane protein | len: 409 aa | Contains 6 probable transmembrane helices predicted by TMHMM2.0 at aa 98-120, 135-157, 198-220, 235-257, 277-299 and 319-341; hypothetical protein	complement(1515100..1516329)	Ehrlichia ruminantium str. Welgevonden	3233262
Erumt01	tRNA	tRNA-Arg	NC_005295.2	11530	11606	D	tRNA-Arg	11530..11606	Ehrlichia ruminantium str. Welgevonden	3232749
Erumt02	tRNA	tRNA-Gln	NC_005295.2	14325	14399	R	tRNA-Gln	complement(14325..14399)	Ehrlichia ruminantium str. Welgevonden	3232756
Erumt03	tRNA	tRNA-Leu	NC_005295.2	38776	38865	R	tRNA-Leu	complement(38776..38865)	Ehrlichia ruminantium str. Welgevonden	3232763
Erumt04	tRNA	tRNA-Val	NC_005295.2	64275	64348	D	tRNA-Val	64275..64348	Ehrlichia ruminantium str. Welgevonden	3232782
Erumt05	tRNA	tRNA-Lys	NC_005295.2	89797	89869	D	tRNA-Lys	89797..89869	Ehrlichia ruminantium str. Welgevonden	3232767
Erumt06	tRNA	tRNA-Cys	NC_005295.2	96173	96245	R	tRNA-Cys	complement(96173..96245)	Ehrlichia ruminantium str. Welgevonden	3232755
Erumt07	tRNA	tRNA-Leu	NC_005295.2	175655	175742	R	tRNA-Leu	complement(175655..175742)	Ehrlichia ruminantium str. Welgevonden	3232764
Erumt08	tRNA	tRNA-Pro	NC_005295.2	190207	190285	D	tRNA-Pro	190207..190285	Ehrlichia ruminantium str. Welgevonden	3232773
Erumt09	tRNA	tRNA-Ser	NC_005295.2	190985	191072	R	tRNA-Ser	complement(190985..191072)	Ehrlichia ruminantium str. Welgevonden	3232777
Erumt10	tRNA	tRNA-Ala	NC_005295.2	224163	224235	D	tRNA-Ala	224163..224235	Ehrlichia ruminantium str. Welgevonden	3232748
Erumt11	tRNA	tRNA-Trp	NC_005295.2	284300	284376	D	tRNA-Trp	284300..284376	Ehrlichia ruminantium str. Welgevonden	3232780
Erumt12	tRNA	tRNA-Arg	NC_005295.2	298339	298412	D	tRNA-Arg	298339..298412	Ehrlichia ruminantium str. Welgevonden	3232750
Erumt13	tRNA	tRNA-Leu	NC_005295.2	334549	334634	R	tRNA-Leu	complement(334549..334634)	Ehrlichia ruminantium str. Welgevonden	3232765
Erumt14	tRNA	tRNA-Lys	NC_005295.2	341296	341368	D	tRNA-Lys	341296..341368	Ehrlichia ruminantium str. Welgevonden	3232768
Erumt15	tRNA	tRNA-Leu	NC_005295.2	341561	341642	D	tRNA-Leu	341561..341642	Ehrlichia ruminantium str. Welgevonden	3232762
Erumt16	tRNA	tRNA-Met	NC_005295.2	348491	348564	D	tRNA-Met	348491..348564	Ehrlichia ruminantium str. Welgevonden	3232769
Erumt17	tRNA	tRNA-Gly	NC_005295.2	423750	423822	D	tRNA-Gly	423750..423822	Ehrlichia ruminantium str. Welgevonden	3232758
Erumt18	tRNA	tRNA-Asp	NC_005295.2	505327	505400	D	tRNA-Asp	505327..505400	Ehrlichia ruminantium str. Welgevonden	3232754
Erumt19	tRNA	tRNA-Asn	NC_005295.2	595131	595203	R	tRNA-Asn	complement(595131..595203)	Ehrlichia ruminantium str. Welgevonden	3232753
Erumt20	tRNA	tRNA-Phe	NC_005295.2	599803	599875	R	tRNA-Phe	complement(599803..599875)	Ehrlichia ruminantium str. Welgevonden	3232772
Erumt21	tRNA	tRNA-Arg	NC_005295.2	610975	611048	R	tRNA-Arg	complement(610975..611048)	Ehrlichia ruminantium str. Welgevonden	3232751
Erumt22	tRNA	tRNA-Met	NC_005295.2	659731	659805	D	tRNA-Met	659731..659805	Ehrlichia ruminantium str. Welgevonden	3232770
Erumt23	tRNA	tRNA-Met	NC_005295.2	672998	673071	D	tRNA-Met	672998..673071	Ehrlichia ruminantium str. Welgevonden	3232771
Erumt24	tRNA	tRNA-Ser	NC_005295.2	689068	689159	D	tRNA-Ser	689068..689159	Ehrlichia ruminantium str. Welgevonden	3232775
Erumt25	tRNA	tRNA-Thr	NC_005295.2	707168	707241	D	tRNA-Thr	707168..707241	Ehrlichia ruminantium str. Welgevonden	3232778
Erumt26	tRNA	tRNA-Thr	NC_005295.2	745710	745780	R	tRNA-Thr	complement(745710..745780)	Ehrlichia ruminantium str. Welgevonden	3232779
Erumt27	tRNA	tRNA-Leu	NC_005295.2	787452	787535	R	tRNA-Leu	complement(787452..787535)	Ehrlichia ruminantium str. Welgevonden	3232766
Erumt28	tRNA	tRNA-Ile	NC_005295.2	823104	823180	R	tRNA-Ile	complement(823104..823180)	Ehrlichia ruminantium str. Welgevonden	3232761
Erumt29	tRNA	tRNA-Pro	NC_005295.2	841324	841400	R	tRNA-Pro	complement(841324..841400)	Ehrlichia ruminantium str. Welgevonden	3232774
Erumt30	tRNA	tRNA-Arg	NC_005295.2	905281	905353	R	tRNA-Arg	complement(905281..905353)	Ehrlichia ruminantium str. Welgevonden	3232752
Erumt31	tRNA	tRNA-Glu	NC_005295.2	975333	975405	R	tRNA-Glu	complement(975333..975405)	Ehrlichia ruminantium str. Welgevonden	3232757
Erumt32	tRNA	tRNA-Gly	NC_005295.2	1023862	1023932	R	tRNA-Gly	complement(1023862..1023932)	Ehrlichia ruminantium str. Welgevonden	3232759
Erumt33	tRNA	tRNA-Tyr	NC_005295.2	1023941	1024023	R	tRNA-Tyr	complement(1023941..1024023)	Ehrlichia ruminantium str. Welgevonden	3232781
Erumt34	tRNA	tRNA-Val	NC_005295.2	1139243	1139315	R	tRNA-Val	complement(1139243..1139315)	Ehrlichia ruminantium str. Welgevonden	3232783
Erumt35	tRNA	tRNA-His	NC_005295.2	1302588	1302664	R	tRNA-His	complement(1302588..1302664)	Ehrlichia ruminantium str. Welgevonden	3232760
Erumt36	tRNA	tRNA-Ser	NC_005295.2	1443332	1443421	D	tRNA-Ser	1443332..1443421	Ehrlichia ruminantium str. Welgevonden	3232776
Erumr01	rRNA	Erumr01	NC_005295.2	326964	328421	D	16S ribosomal RNA	326964..328421	Ehrlichia ruminantium str. Welgevonden	3233263
Erumr02	rRNA	Erumr02	NC_005295.2	1283569	1283687	R	5S ribosomal RNA	complement(1283569..1283687)	Ehrlichia ruminantium str. Welgevonden	3233265
Erumr03	rRNA	Erumr03	NC_005295.2	1283759	1286544	R	23S ribosomal RNA	complement(1283759..1286544)	Ehrlichia ruminantium str. Welgevonden	3233264