-- dump date 20140619_070353 -- class Genbank::misc_feature -- table misc_feature_note -- id note 205920000001 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 205920000002 ParB-like nuclease domain; Region: ParB; smart00470 205920000003 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14592 205920000004 RimM N-terminal domain; Region: RimM; pfam01782 205920000005 PRC-barrel domain; Region: PRC; pfam05239 205920000006 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 205920000007 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 205920000008 Competence-damaged protein; Region: CinA; pfam02464 205920000009 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 205920000010 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 205920000011 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 205920000012 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 205920000013 active site 205920000014 dimer interface [polypeptide binding]; other site 205920000015 motif 1; other site 205920000016 motif 2; other site 205920000017 motif 3; other site 205920000018 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 205920000019 anticodon binding site; other site 205920000020 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 205920000021 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 205920000022 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 205920000023 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 205920000024 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 205920000025 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 205920000026 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 205920000027 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 205920000028 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 205920000029 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 205920000030 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 205920000031 conserved cys residue [active] 205920000032 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 205920000033 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 205920000034 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14964 205920000035 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205920000036 Walker A motif; other site 205920000037 ATP binding site [chemical binding]; other site 205920000038 Walker B motif; other site 205920000039 arginine finger; other site 205920000040 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 205920000041 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 205920000042 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 205920000043 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 205920000044 S-adenosylmethionine synthetase; Validated; Region: PRK05250 205920000045 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 205920000046 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 205920000047 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 205920000048 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 205920000049 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 205920000050 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 205920000051 motif 1; other site 205920000052 dimer interface [polypeptide binding]; other site 205920000053 active site 205920000054 motif 2; other site 205920000055 motif 3; other site 205920000056 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 205920000057 DALR anticodon binding domain; Region: DALR_1; pfam05746 205920000058 chaperone protein DnaJ; Provisional; Region: PRK10767 205920000059 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 205920000060 HSP70 interaction site [polypeptide binding]; other site 205920000061 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 205920000062 substrate binding site [polypeptide binding]; other site 205920000063 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 205920000064 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 205920000065 dimer interface [polypeptide binding]; other site 205920000066 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 205920000067 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 205920000068 dimerization interface [polypeptide binding]; other site 205920000069 active site 205920000070 membrane protein; Provisional; Region: PRK14394 205920000071 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 205920000072 active site 205920000073 putative DNA-binding cleft [nucleotide binding]; other site 205920000074 dimer interface [polypeptide binding]; other site 205920000075 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 205920000076 Subunit III/VIIa interface [polypeptide binding]; other site 205920000077 Phospholipid binding site [chemical binding]; other site 205920000078 Subunit I/III interface [polypeptide binding]; other site 205920000079 Subunit III/VIb interface [polypeptide binding]; other site 205920000080 Subunit III/VIa interface; other site 205920000081 Subunit III/Vb interface [polypeptide binding]; other site 205920000082 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 205920000083 substrate binding site [chemical binding]; other site 205920000084 active site 205920000085 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 205920000086 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 205920000087 Transporter associated domain; Region: CorC_HlyC; smart01091 205920000088 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 205920000089 Phage-related protein [Function unknown]; Region: COG4695 205920000090 Phage portal protein; Region: Phage_portal; pfam04860 205920000091 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 205920000092 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205920000093 S-adenosylmethionine binding site [chemical binding]; other site 205920000094 quinolinate synthetase; Provisional; Region: PRK09375 205920000095 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 205920000096 4Fe-4S binding domain; Region: Fer4; pfam00037 205920000097 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 205920000098 Ehrlichia tandem repeat (Ehrlichia_rpt); Region: Ehrlichia_rpt; pfam09528 205920000099 Ehrlichia chaffeensis immunodominant surface protein repeat; Region: Ehrlichia_rpt; TIGR02202 205920000100 Ehrlichia chaffeensis immunodominant surface protein repeat; Region: Ehrlichia_rpt; TIGR02202 205920000101 Ehrlichia chaffeensis immunodominant surface protein repeat; Region: Ehrlichia_rpt; TIGR02202 205920000102 Ehrlichia chaffeensis immunodominant surface protein repeat; Region: Ehrlichia_rpt; TIGR02202 205920000103 Ehrlichia chaffeensis immunodominant surface protein repeat; Region: Ehrlichia_rpt; TIGR02202 205920000104 type IV secretion system component VirD4; Provisional; Region: PRK13897 205920000105 The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126 205920000106 Walker A motif; other site 205920000107 ATP binding site [chemical binding]; other site 205920000108 Walker B motif; other site 205920000109 type IV secretion system ATPase VirB11; Provisional; Region: PRK13900 205920000110 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 205920000111 ATP binding site [chemical binding]; other site 205920000112 Walker B motif; other site 205920000113 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 205920000114 Type IV secretory pathway, VirB9 components [Intracellular trafficking and secretion]; Region: VirB9; COG3504 205920000115 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 205920000116 VirB7 interaction site; other site 205920000117 VirB8 protein; Region: VirB8; pfam04335 205920000118 GTP cyclohydrolase; Provisional; Region: PRK08815 205920000119 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 205920000120 dimerization interface [polypeptide binding]; other site 205920000121 active site 205920000122 Tetratricopeptide repeat; Region: TPR_12; pfam13424 205920000123 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 205920000124 binding surface 205920000125 TPR motif; other site 205920000126 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205920000127 S-adenosylmethionine binding site [chemical binding]; other site 205920000128 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 205920000129 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 205920000130 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 205920000131 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 205920000132 Phosphoglycerate kinase; Region: PGK; pfam00162 205920000133 substrate binding site [chemical binding]; other site 205920000134 hinge regions; other site 205920000135 ADP binding site [chemical binding]; other site 205920000136 catalytic site [active] 205920000137 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 205920000138 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 205920000139 generic binding surface II; other site 205920000140 generic binding surface I; other site 205920000141 zinc-ribbon domain; Region: zinc_ribbon_4; pfam13717 205920000142 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 205920000143 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 205920000144 trimer interface [polypeptide binding]; other site 205920000145 active site 205920000146 substrate binding site [chemical binding]; other site 205920000147 CoA binding site [chemical binding]; other site 205920000148 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 205920000149 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 205920000150 trmE is a tRNA modification GTPase; Region: trmE; cd04164 205920000151 G1 box; other site 205920000152 GTP/Mg2+ binding site [chemical binding]; other site 205920000153 Switch I region; other site 205920000154 G2 box; other site 205920000155 Switch II region; other site 205920000156 G3 box; other site 205920000157 G4 box; other site 205920000158 G5 box; other site 205920000159 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 205920000160 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 205920000161 Flavoprotein; Region: Flavoprotein; pfam02441 205920000162 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 205920000163 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 205920000164 generic binding surface II; other site 205920000165 ssDNA binding site; other site 205920000166 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205920000167 ATP binding site [chemical binding]; other site 205920000168 putative Mg++ binding site [ion binding]; other site 205920000169 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205920000170 nucleotide binding region [chemical binding]; other site 205920000171 ATP-binding site [chemical binding]; other site 205920000172 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 205920000173 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 205920000174 putative NAD(P) binding site [chemical binding]; other site 205920000175 active site 205920000176 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 205920000177 CcmB protein; Region: CcmB; cl17444 205920000178 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 205920000179 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 205920000180 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 205920000181 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 205920000182 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 205920000183 putative acyl-acceptor binding pocket; other site 205920000184 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 205920000185 active site 205920000186 catalytic residues [active] 205920000187 metal binding site [ion binding]; metal-binding site 205920000188 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 205920000189 Fe-S cluster binding site [ion binding]; other site 205920000190 active site 205920000191 recombination protein F; Reviewed; Region: recF; PRK00064 205920000192 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205920000193 Walker A/P-loop; other site 205920000194 ATP binding site [chemical binding]; other site 205920000195 Q-loop/lid; other site 205920000196 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205920000197 ABC transporter signature motif; other site 205920000198 Walker B; other site 205920000199 D-loop; other site 205920000200 H-loop/switch region; other site 205920000201 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 205920000202 ornithine carbamoyltransferase; Provisional; Region: PRK00779 205920000203 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 205920000204 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 205920000205 5'-3' exonuclease; Region: 53EXOc; smart00475 205920000206 active site 205920000207 metal binding site 1 [ion binding]; metal-binding site 205920000208 putative 5' ssDNA interaction site; other site 205920000209 metal binding site 3; metal-binding site 205920000210 metal binding site 2 [ion binding]; metal-binding site 205920000211 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 205920000212 putative DNA binding site [nucleotide binding]; other site 205920000213 putative metal binding site [ion binding]; other site 205920000214 DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749 205920000215 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 205920000216 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 205920000217 active site 205920000218 DNA binding site [nucleotide binding] 205920000219 catalytic site [active] 205920000220 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 205920000221 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 205920000222 substrate binding site [chemical binding]; other site 205920000223 hexamer interface [polypeptide binding]; other site 205920000224 metal binding site [ion binding]; metal-binding site 205920000225 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 205920000226 Permease; Region: Permease; pfam02405 205920000227 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 205920000228 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 205920000229 Walker A/P-loop; other site 205920000230 ATP binding site [chemical binding]; other site 205920000231 Q-loop/lid; other site 205920000232 ABC transporter signature motif; other site 205920000233 Walker B; other site 205920000234 D-loop; other site 205920000235 H-loop/switch region; other site 205920000236 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 205920000237 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 205920000238 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 205920000239 substrate binding pocket [chemical binding]; other site 205920000240 chain length determination region; other site 205920000241 substrate-Mg2+ binding site; other site 205920000242 catalytic residues [active] 205920000243 aspartate-rich region 1; other site 205920000244 active site lid residues [active] 205920000245 aspartate-rich region 2; other site 205920000246 glutamine synthetase; Provisional; Region: glnA; PRK09469 205920000247 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 205920000248 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 205920000249 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 205920000250 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 205920000251 active site 205920000252 HIGH motif; other site 205920000253 dimer interface [polypeptide binding]; other site 205920000254 KMSKS motif; other site 205920000255 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 205920000256 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 205920000257 substrate-cofactor binding pocket; other site 205920000258 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205920000259 catalytic residue [active] 205920000260 hypothetical protein; Provisional; Region: PRK14683 205920000261 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 205920000262 Protein export membrane protein; Region: SecD_SecF; pfam02355 205920000263 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 205920000264 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 205920000265 putative active site; other site 205920000266 catalytic residue [active] 205920000267 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 205920000268 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 205920000269 E3 interaction surface; other site 205920000270 lipoyl attachment site [posttranslational modification]; other site 205920000271 e3 binding domain; Region: E3_binding; pfam02817 205920000272 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 205920000273 Protein of unknown function (DUF3514); Region: DUF3514; pfam12027 205920000274 Protein of unknown function (DUF3514); Region: DUF3514; pfam12027 205920000275 Protein of unknown function (DUF3514); Region: DUF3514; pfam12027 205920000276 Protein of unknown function (DUF3514); Region: DUF3514; pfam12027 205920000277 Protein of unknown function (DUF3514); Region: DUF3514; pfam12027 205920000278 Protein of unknown function (DUF3514); Region: DUF3514; pfam12027 205920000279 Protein of unknown function (DUF3514); Region: DUF3514; pfam12027 205920000280 Protein of unknown function (DUF3514); Region: DUF3514; pfam12027 205920000281 Protein of unknown function (DUF3514); Region: DUF3514; pfam12027 205920000282 GMP synthase; Reviewed; Region: guaA; PRK00074 205920000283 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 205920000284 AMP/PPi binding site [chemical binding]; other site 205920000285 candidate oxyanion hole; other site 205920000286 catalytic triad [active] 205920000287 potential glutamine specificity residues [chemical binding]; other site 205920000288 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 205920000289 ATP Binding subdomain [chemical binding]; other site 205920000290 Ligand Binding sites [chemical binding]; other site 205920000291 Dimerization subdomain; other site 205920000292 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 205920000293 Citrate synthase; Region: Citrate_synt; pfam00285 205920000294 oxalacetate binding site [chemical binding]; other site 205920000295 citrylCoA binding site [chemical binding]; other site 205920000296 coenzyme A binding site [chemical binding]; other site 205920000297 catalytic triad [active] 205920000298 Glutamate-cysteine ligase; Region: GshA; pfam08886 205920000299 glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049 205920000300 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 205920000301 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 205920000302 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 205920000303 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 205920000304 FtsX-like permease family; Region: FtsX; pfam02687 205920000305 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 205920000306 Protein of unknown function (DUF1467); Region: DUF1467; pfam07330 205920000307 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 205920000308 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 205920000309 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 205920000310 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 205920000311 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 205920000312 beta subunit interaction interface [polypeptide binding]; other site 205920000313 Walker A motif; other site 205920000314 ATP binding site [chemical binding]; other site 205920000315 Walker B motif; other site 205920000316 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 205920000317 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 205920000318 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 205920000319 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 205920000320 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 205920000321 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 205920000322 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 205920000323 SmpB-tmRNA interface; other site 205920000324 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 205920000325 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 205920000326 active site 205920000327 HIGH motif; other site 205920000328 nucleotide binding site [chemical binding]; other site 205920000329 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 205920000330 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 205920000331 active site 205920000332 KMSKS motif; other site 205920000333 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 205920000334 tRNA binding surface [nucleotide binding]; other site 205920000335 anticodon binding site; other site 205920000336 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 205920000337 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 205920000338 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 205920000339 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 205920000340 amidophosphoribosyltransferase; Provisional; Region: PRK09123 205920000341 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 205920000342 active site 205920000343 tetramer interface [polypeptide binding]; other site 205920000344 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 205920000345 active site 205920000346 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 205920000347 putative active site [active] 205920000348 catalytic residue [active] 205920000349 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 205920000350 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 205920000351 5S rRNA interface [nucleotide binding]; other site 205920000352 CTC domain interface [polypeptide binding]; other site 205920000353 L16 interface [polypeptide binding]; other site 205920000354 DNA utilization protein GntX; Provisional; Region: PRK11595 205920000355 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 205920000356 active site 205920000357 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 205920000358 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 205920000359 metal binding site [ion binding]; metal-binding site 205920000360 dimer interface [polypeptide binding]; other site 205920000361 putative cation:proton antiport protein; Provisional; Region: PRK10669 205920000362 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 205920000363 TrkA-N domain; Region: TrkA_N; pfam02254 205920000364 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 205920000365 putative catalytic residue [active] 205920000366 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 205920000367 pyruvate dehydrogenase subunit beta; Validated; Region: PRK09212 205920000368 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 205920000369 alpha subunit interface [polypeptide binding]; other site 205920000370 TPP binding site [chemical binding]; other site 205920000371 heterodimer interface [polypeptide binding]; other site 205920000372 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 205920000373 protease TldD; Provisional; Region: tldD; PRK10735 205920000374 GTP-binding protein YchF; Reviewed; Region: PRK09601 205920000375 YchF GTPase; Region: YchF; cd01900 205920000376 G1 box; other site 205920000377 GTP/Mg2+ binding site [chemical binding]; other site 205920000378 Switch I region; other site 205920000379 G2 box; other site 205920000380 Switch II region; other site 205920000381 G3 box; other site 205920000382 G4 box; other site 205920000383 G5 box; other site 205920000384 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 205920000385 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 205920000386 G1 box; other site 205920000387 GTP/Mg2+ binding site [chemical binding]; other site 205920000388 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 205920000389 homotrimer interaction site [polypeptide binding]; other site 205920000390 zinc binding site [ion binding]; other site 205920000391 CDP-binding sites; other site 205920000392 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 205920000393 substrate binding site; other site 205920000394 dimer interface; other site 205920000395 AIR carboxylase; Region: AIRC; pfam00731 205920000396 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 205920000397 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 205920000398 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 205920000399 IHF - DNA interface [nucleotide binding]; other site 205920000400 IHF dimer interface [polypeptide binding]; other site 205920000401 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 205920000402 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 205920000403 DNA binding residues [nucleotide binding] 205920000404 ribonuclease E; Reviewed; Region: rne; PRK10811 205920000405 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 205920000406 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 205920000407 active site 205920000408 HIGH motif; other site 205920000409 dimer interface [polypeptide binding]; other site 205920000410 KMSKS motif; other site 205920000411 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 205920000412 GrpE; Region: GrpE; pfam01025 205920000413 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 205920000414 dimer interface [polypeptide binding]; other site 205920000415 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 205920000416 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 205920000417 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 205920000418 catalytic motif [active] 205920000419 Zn binding site [ion binding]; other site 205920000420 RibD C-terminal domain; Region: RibD_C; cl17279 205920000421 Variable length PCR target protein (VLPT); Region: VLPT; pfam07122 205920000422 Variable length PCR target protein (VLPT); Region: VLPT; pfam07122 205920000423 Variable length PCR target protein (VLPT); Region: VLPT; pfam07122 205920000424 CTP synthetase; Validated; Region: pyrG; PRK05380 205920000425 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 205920000426 Catalytic site [active] 205920000427 active site 205920000428 UTP binding site [chemical binding]; other site 205920000429 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 205920000430 active site 205920000431 putative oxyanion hole; other site 205920000432 catalytic triad [active] 205920000433 Preprotein translocase SecG subunit; Region: SecG; pfam03840 205920000434 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 205920000435 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 205920000436 active site 205920000437 DNA binding site [nucleotide binding] 205920000438 Int/Topo IB signature motif; other site 205920000439 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 205920000440 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 205920000441 Walker A/P-loop; other site 205920000442 ATP binding site [chemical binding]; other site 205920000443 Q-loop/lid; other site 205920000444 ABC transporter signature motif; other site 205920000445 Walker B; other site 205920000446 D-loop; other site 205920000447 H-loop/switch region; other site 205920000448 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 205920000449 Malic enzyme, N-terminal domain; Region: malic; pfam00390 205920000450 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 205920000451 putative NAD(P) binding site [chemical binding]; other site 205920000452 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 205920000453 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 205920000454 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 205920000455 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 205920000456 putative active site [active] 205920000457 catalytic triad [active] 205920000458 putative dimer interface [polypeptide binding]; other site 205920000459 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12662 205920000460 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 205920000461 mce related protein; Region: MCE; pfam02470 205920000462 NADH ubiquinone oxidoreductase subunit NDUFA12; Region: NDUFA12; cl01534 205920000463 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 205920000464 ATP cone domain; Region: ATP-cone; pfam03477 205920000465 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 205920000466 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 205920000467 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 205920000468 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 205920000469 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205920000470 metabolite-proton symporter; Region: 2A0106; TIGR00883 205920000471 putative substrate translocation pore; other site 205920000472 Uncharacterized conserved protein [Function unknown]; Region: COG2835 205920000473 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205920000474 NAD(P) binding site [chemical binding]; other site 205920000475 active site 205920000476 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 205920000477 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 205920000478 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 205920000479 dimer interface [polypeptide binding]; other site 205920000480 motif 1; other site 205920000481 active site 205920000482 motif 2; other site 205920000483 motif 3; other site 205920000484 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 205920000485 23S rRNA binding site [nucleotide binding]; other site 205920000486 L21 binding site [polypeptide binding]; other site 205920000487 L13 binding site [polypeptide binding]; other site 205920000488 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 205920000489 Protein of unknown function (DUF1013); Region: DUF1013; pfam06242 205920000490 transcription termination factor Rho; Provisional; Region: rho; PRK09376 205920000491 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 205920000492 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 205920000493 RNA binding site [nucleotide binding]; other site 205920000494 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 205920000495 multimer interface [polypeptide binding]; other site 205920000496 Walker A motif; other site 205920000497 ATP binding site [chemical binding]; other site 205920000498 Walker B motif; other site 205920000499 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 205920000500 HSP70 interaction site [polypeptide binding]; other site 205920000501 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 205920000502 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 205920000503 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 205920000504 thiS-thiF/thiG interaction site; other site 205920000505 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 205920000506 ThiS interaction site; other site 205920000507 putative active site [active] 205920000508 tetramer interface [polypeptide binding]; other site 205920000509 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 205920000510 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 205920000511 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 205920000512 active site 205920000513 HIGH motif; other site 205920000514 nucleotide binding site [chemical binding]; other site 205920000515 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 205920000516 active site 205920000517 KMSKS motif; other site 205920000518 SurA N-terminal domain; Region: SurA_N; pfam09312 205920000519 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 205920000520 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 205920000521 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205920000522 S-adenosylmethionine binding site [chemical binding]; other site 205920000523 Predicted permeases [General function prediction only]; Region: COG0679 205920000524 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 205920000525 Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609 205920000526 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 205920000527 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 205920000528 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 205920000529 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 205920000530 catalytic residues [active] 205920000531 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 205920000532 VirB7 interaction site; other site 205920000533 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 205920000534 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 205920000535 tetramer interface [polypeptide binding]; other site 205920000536 TPP-binding site [chemical binding]; other site 205920000537 heterodimer interface [polypeptide binding]; other site 205920000538 phosphorylation loop region [posttranslational modification] 205920000539 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 205920000540 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 205920000541 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 205920000542 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 205920000543 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 205920000544 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 205920000545 active site 205920000546 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 205920000547 ATP-NAD kinase; Region: NAD_kinase; pfam01513 205920000548 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 205920000549 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 205920000550 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 205920000551 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 205920000552 thymidylate kinase; Validated; Region: tmk; PRK00698 205920000553 TMP-binding site; other site 205920000554 ATP-binding site [chemical binding]; other site 205920000555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205920000556 putative substrate translocation pore; other site 205920000557 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205920000558 Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978 205920000559 preprotein translocase subunit SecB; Validated; Region: PRK05751 205920000560 SecA binding site; other site 205920000561 Preprotein binding site; other site 205920000562 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 205920000563 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 205920000564 catalytic residues [active] 205920000565 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 205920000566 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 205920000567 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 205920000568 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 205920000569 FMN binding site [chemical binding]; other site 205920000570 substrate binding site [chemical binding]; other site 205920000571 putative catalytic residue [active] 205920000572 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 205920000573 Lumazine binding domain; Region: Lum_binding; pfam00677 205920000574 Lumazine binding domain; Region: Lum_binding; pfam00677 205920000575 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 205920000576 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 205920000577 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205920000578 ATP binding site [chemical binding]; other site 205920000579 putative Mg++ binding site [ion binding]; other site 205920000580 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205920000581 nucleotide binding region [chemical binding]; other site 205920000582 ATP-binding site [chemical binding]; other site 205920000583 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 205920000584 SUR7/PalI family; Region: SUR7; pfam06687 205920000585 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 205920000586 RNA/DNA hybrid binding site [nucleotide binding]; other site 205920000587 active site 205920000588 Protein of unknown function; Region: DUF3971; pfam13116 205920000589 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 205920000590 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 205920000591 putative nucleotide binding site [chemical binding]; other site 205920000592 uridine monophosphate binding site [chemical binding]; other site 205920000593 homohexameric interface [polypeptide binding]; other site 205920000594 ribosome recycling factor; Reviewed; Region: frr; PRK00083 205920000595 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 205920000596 hinge region; other site 205920000597 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 205920000598 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 205920000599 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 205920000600 active site 205920000601 DNA binding site [nucleotide binding] 205920000602 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 205920000603 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 205920000604 ATP binding site [chemical binding]; other site 205920000605 active site 205920000606 substrate binding site [chemical binding]; other site 205920000607 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 205920000608 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 205920000609 dimer interface [polypeptide binding]; other site 205920000610 motif 1; other site 205920000611 active site 205920000612 motif 2; other site 205920000613 motif 3; other site 205920000614 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 205920000615 anticodon binding site; other site 205920000616 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 205920000617 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 205920000618 catalytic residues [active] 205920000619 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 205920000620 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 205920000621 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 205920000622 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205920000623 Walker A/P-loop; other site 205920000624 ATP binding site [chemical binding]; other site 205920000625 Q-loop/lid; other site 205920000626 ABC transporter signature motif; other site 205920000627 Walker B; other site 205920000628 D-loop; other site 205920000629 H-loop/switch region; other site 205920000630 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 205920000631 trimer interface [polypeptide binding]; other site 205920000632 active site 205920000633 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 205920000634 putative NAD(P) binding site [chemical binding]; other site 205920000635 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 205920000636 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 205920000637 DNA-binding site [nucleotide binding]; DNA binding site 205920000638 RNA-binding motif; other site 205920000639 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 205920000640 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205920000641 dimerization interface [polypeptide binding]; other site 205920000642 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205920000643 dimer interface [polypeptide binding]; other site 205920000644 phosphorylation site [posttranslational modification] 205920000645 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205920000646 ATP binding site [chemical binding]; other site 205920000647 Mg2+ binding site [ion binding]; other site 205920000648 G-X-G motif; other site 205920000649 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 205920000650 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 205920000651 catalytic site [active] 205920000652 putative active site [active] 205920000653 putative substrate binding site [chemical binding]; other site 205920000654 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 205920000655 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 205920000656 nucleotide binding pocket [chemical binding]; other site 205920000657 K-X-D-G motif; other site 205920000658 catalytic site [active] 205920000659 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 205920000660 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 205920000661 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 205920000662 Dimer interface [polypeptide binding]; other site 205920000663 BRCT sequence motif; other site 205920000664 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 205920000665 putative GSH binding site [chemical binding]; other site 205920000666 catalytic residues [active] 205920000667 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 205920000668 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 205920000669 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 205920000670 catalytic residues [active] 205920000671 central insert; other site 205920000672 DNA repair protein RadA; Provisional; Region: PRK11823 205920000673 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 205920000674 Walker A motif; other site 205920000675 ATP binding site [chemical binding]; other site 205920000676 Walker B motif; other site 205920000677 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 205920000678 TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666 205920000679 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 205920000680 Domain of unknown function (DUF3394); Region: DUF3394; pfam11874 205920000681 Colicin V production protein; Region: Colicin_V; pfam02674 205920000682 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 205920000683 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 205920000684 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 205920000685 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 205920000686 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 205920000687 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 205920000688 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 205920000689 dimer interface [polypeptide binding]; other site 205920000690 active site 205920000691 glycine-pyridoxal phosphate binding site [chemical binding]; other site 205920000692 folate binding site [chemical binding]; other site 205920000693 Frataxin-like domain; Region: Frataxin_Cyay; pfam01491 205920000694 putative iron binding site [ion binding]; other site 205920000695 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 205920000696 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 205920000697 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205920000698 Walker A/P-loop; other site 205920000699 ATP binding site [chemical binding]; other site 205920000700 Q-loop/lid; other site 205920000701 ABC transporter signature motif; other site 205920000702 Walker B; other site 205920000703 D-loop; other site 205920000704 H-loop/switch region; other site 205920000705 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 205920000706 L-aspartate oxidase; Provisional; Region: PRK06175 205920000707 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 205920000708 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 205920000709 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 205920000710 catalytic loop [active] 205920000711 iron binding site [ion binding]; other site 205920000712 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 205920000713 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205920000714 putative substrate translocation pore; other site 205920000715 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205920000716 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 205920000717 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205920000718 Walker A motif; other site 205920000719 ATP binding site [chemical binding]; other site 205920000720 Walker B motif; other site 205920000721 arginine finger; other site 205920000722 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 205920000723 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14600 205920000724 RuvA N terminal domain; Region: RuvA_N; pfam01330 205920000725 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 205920000726 heme exporter protein CcmC; Region: ccmC; TIGR01191 205920000727 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 205920000728 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 205920000729 catalytic site [active] 205920000730 G-X2-G-X-G-K; other site 205920000731 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14187 205920000732 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 205920000733 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 205920000734 homodimer interface [polypeptide binding]; other site 205920000735 NADP binding site [chemical binding]; other site 205920000736 substrate binding site [chemical binding]; other site 205920000737 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 205920000738 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 205920000739 Cytochrome c2 [Energy production and conversion]; Region: COG3474 205920000740 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK06589 205920000741 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 205920000742 pyruvate phosphate dikinase; Provisional; Region: PRK09279 205920000743 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 205920000744 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 205920000745 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 205920000746 RDD family; Region: RDD; pfam06271 205920000747 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 205920000748 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205920000749 motif II; other site 205920000750 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 205920000751 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 205920000752 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 205920000753 dimer interface [polypeptide binding]; other site 205920000754 anticodon binding site; other site 205920000755 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 205920000756 homodimer interface [polypeptide binding]; other site 205920000757 motif 1; other site 205920000758 active site 205920000759 motif 2; other site 205920000760 GAD domain; Region: GAD; pfam02938 205920000761 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 205920000762 active site 205920000763 motif 3; other site 205920000764 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 205920000765 BON domain; Region: BON; pfam04972 205920000766 glutathione synthetase; Provisional; Region: PRK05246 205920000767 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 205920000768 ATP-grasp domain; Region: ATP-grasp_4; cl17255 205920000769 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 205920000770 Cell division protein FtsQ; Region: FtsQ; pfam03799 205920000771 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 205920000772 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205920000773 active site 205920000774 phosphorylation site [posttranslational modification] 205920000775 intermolecular recognition site; other site 205920000776 dimerization interface [polypeptide binding]; other site 205920000777 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205920000778 Walker A motif; other site 205920000779 ATP binding site [chemical binding]; other site 205920000780 Walker B motif; other site 205920000781 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 205920000782 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14620 205920000783 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 205920000784 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 205920000785 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 205920000786 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 205920000787 active site 205920000788 DNA binding site [nucleotide binding] 205920000789 Int/Topo IB signature motif; other site 205920000790 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 205920000791 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 205920000792 dimerization interface [polypeptide binding]; other site 205920000793 putative ATP binding site [chemical binding]; other site 205920000794 Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090 205920000795 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 205920000796 putative active site [active] 205920000797 heme pocket [chemical binding]; other site 205920000798 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 205920000799 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 205920000800 Peptidase family M48; Region: Peptidase_M48; cl12018 205920000801 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 205920000802 binding surface 205920000803 TPR motif; other site 205920000804 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 205920000805 catalytic center binding site [active] 205920000806 ATP binding site [chemical binding]; other site 205920000807 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 205920000808 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 205920000809 dimerization interface [polypeptide binding]; other site 205920000810 ATP binding site [chemical binding]; other site 205920000811 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 205920000812 dimerization interface [polypeptide binding]; other site 205920000813 ATP binding site [chemical binding]; other site 205920000814 biotin synthase; Region: bioB; TIGR00433 205920000815 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 205920000816 FeS/SAM binding site; other site 205920000817 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 205920000818 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 205920000819 Peptidase family M23; Region: Peptidase_M23; pfam01551 205920000820 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 205920000821 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 205920000822 putative active site [active] 205920000823 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 205920000824 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 205920000825 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 205920000826 CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507 205920000827 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 205920000828 putative active site [active] 205920000829 catalytic triad [active] 205920000830 hypothetical protein; Reviewed; Region: PRK00024 205920000831 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 205920000832 MPN+ (JAMM) motif; other site 205920000833 Zinc-binding site [ion binding]; other site 205920000834 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 205920000835 oligomerisation interface [polypeptide binding]; other site 205920000836 mobile loop; other site 205920000837 roof hairpin; other site 205920000838 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 205920000839 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 205920000840 ring oligomerisation interface [polypeptide binding]; other site 205920000841 ATP/Mg binding site [chemical binding]; other site 205920000842 stacking interactions; other site 205920000843 hinge regions; other site 205920000844 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 205920000845 classical (c) SDRs; Region: SDR_c; cd05233 205920000846 NAD(P) binding site [chemical binding]; other site 205920000847 active site 205920000848 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 205920000849 Clp amino terminal domain; Region: Clp_N; pfam02861 205920000850 Clp amino terminal domain; Region: Clp_N; pfam02861 205920000851 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205920000852 Walker A motif; other site 205920000853 ATP binding site [chemical binding]; other site 205920000854 Walker B motif; other site 205920000855 arginine finger; other site 205920000856 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205920000857 Walker A motif; other site 205920000858 ATP binding site [chemical binding]; other site 205920000859 Walker B motif; other site 205920000860 arginine finger; other site 205920000861 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 205920000862 Protocatechuate 3,4-dioxygenase (3,4-PCD) catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and beta-subunit and an Fe3+ ion...; Region: 3,4-PCD; cd03459 205920000863 multifunctional aminopeptidase A; Provisional; Region: PRK00913 205920000864 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 205920000865 interface (dimer of trimers) [polypeptide binding]; other site 205920000866 Substrate-binding/catalytic site; other site 205920000867 Zn-binding sites [ion binding]; other site 205920000868 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 205920000869 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 205920000870 active site 205920000871 substrate binding site [chemical binding]; other site 205920000872 cosubstrate binding site; other site 205920000873 catalytic site [active] 205920000874 lipoate-protein ligase B; Provisional; Region: PRK14341 205920000875 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 205920000876 dihydroorotase; Validated; Region: pyrC; PRK09357 205920000877 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 205920000878 active site 205920000879 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 205920000880 fumarate hydratase; Reviewed; Region: fumC; PRK00485 205920000881 Class II fumarases; Region: Fumarase_classII; cd01362 205920000882 active site 205920000883 tetramer interface [polypeptide binding]; other site 205920000884 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 205920000885 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 205920000886 ATP-grasp domain; Region: ATP-grasp_4; cl17255 205920000887 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 205920000888 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 205920000889 ATP-grasp domain; Region: ATP-grasp_4; cl17255 205920000890 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 205920000891 IMP binding site; other site 205920000892 dimer interface [polypeptide binding]; other site 205920000893 interdomain contacts; other site 205920000894 partial ornithine binding site; other site 205920000895 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 205920000896 dihydropteroate synthase; Region: DHPS; TIGR01496 205920000897 substrate binding pocket [chemical binding]; other site 205920000898 dimer interface [polypeptide binding]; other site 205920000899 inhibitor binding site; inhibition site 205920000900 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 205920000901 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 205920000902 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205920000903 Walker A/P-loop; other site 205920000904 ATP binding site [chemical binding]; other site 205920000905 Q-loop/lid; other site 205920000906 ABC transporter signature motif; other site 205920000907 Walker B; other site 205920000908 D-loop; other site 205920000909 H-loop/switch region; other site 205920000910 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 205920000911 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 205920000912 NADP binding site [chemical binding]; other site 205920000913 dimer interface [polypeptide binding]; other site 205920000914 Part of AAA domain; Region: AAA_19; pfam13245 205920000915 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 205920000916 Family description; Region: UvrD_C_2; pfam13538 205920000917 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 205920000918 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 205920000919 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 205920000920 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 205920000921 Predicted ATPase [General function prediction only]; Region: COG1485 205920000922 ferrochelatase; Reviewed; Region: hemH; PRK00035 205920000923 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 205920000924 C-terminal domain interface [polypeptide binding]; other site 205920000925 active site 205920000926 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 205920000927 active site 205920000928 N-terminal domain interface [polypeptide binding]; other site 205920000929 Cell division protein ZapA; Region: ZapA; pfam05164 205920000930 Domain of unknown function (DUF4164); Region: DUF4164; pfam13747 205920000931 Bacterial DNA-binding protein; Region: Bac_DNA_binding; pfam00216 205920000932 IHF - DNA interface [nucleotide binding]; other site 205920000933 IHF dimer interface [polypeptide binding]; other site 205920000934 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 205920000935 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 205920000936 tandem repeat interface [polypeptide binding]; other site 205920000937 oligomer interface [polypeptide binding]; other site 205920000938 active site residues [active] 205920000939 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 205920000940 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 205920000941 RNA binding site [nucleotide binding]; other site 205920000942 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 205920000943 RNA binding site [nucleotide binding]; other site 205920000944 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 205920000945 RNA binding site [nucleotide binding]; other site 205920000946 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 205920000947 RNA binding site [nucleotide binding]; other site 205920000948 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 205920000949 RNA binding site [nucleotide binding]; other site 205920000950 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 205920000951 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 205920000952 CMP-binding site; other site 205920000953 The sites determining sugar specificity; other site 205920000954 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 205920000955 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 205920000956 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 205920000957 elongation factor Tu; Reviewed; Region: PRK00049 205920000958 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 205920000959 G1 box; other site 205920000960 GEF interaction site [polypeptide binding]; other site 205920000961 GTP/Mg2+ binding site [chemical binding]; other site 205920000962 Switch I region; other site 205920000963 G2 box; other site 205920000964 G3 box; other site 205920000965 Switch II region; other site 205920000966 G4 box; other site 205920000967 G5 box; other site 205920000968 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 205920000969 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 205920000970 Antibiotic Binding Site [chemical binding]; other site 205920000971 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 205920000972 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 205920000973 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 205920000974 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 205920000975 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 205920000976 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 205920000977 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 205920000978 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 205920000979 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 205920000980 protein-rRNA interface [nucleotide binding]; other site 205920000981 putative translocon binding site; other site 205920000982 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 205920000983 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 205920000984 G-X-X-G motif; other site 205920000985 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 205920000986 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 205920000987 23S rRNA interface [nucleotide binding]; other site 205920000988 5S rRNA interface [nucleotide binding]; other site 205920000989 putative antibiotic binding site [chemical binding]; other site 205920000990 L25 interface [polypeptide binding]; other site 205920000991 L27 interface [polypeptide binding]; other site 205920000992 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 205920000993 putative translocon interaction site; other site 205920000994 23S rRNA interface [nucleotide binding]; other site 205920000995 signal recognition particle (SRP54) interaction site; other site 205920000996 L23 interface [polypeptide binding]; other site 205920000997 trigger factor interaction site; other site 205920000998 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 205920000999 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 205920001000 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 205920001001 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 205920001002 RNA binding site [nucleotide binding]; other site 205920001003 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 205920001004 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 205920001005 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 205920001006 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 205920001007 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 205920001008 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 205920001009 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 205920001010 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 205920001011 5S rRNA interface [nucleotide binding]; other site 205920001012 23S rRNA interface [nucleotide binding]; other site 205920001013 L5 interface [polypeptide binding]; other site 205920001014 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 205920001015 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 205920001016 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 205920001017 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 205920001018 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 205920001019 SecY translocase; Region: SecY; pfam00344 205920001020 adenylate kinase; Reviewed; Region: adk; PRK00279 205920001021 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 205920001022 AMP-binding site [chemical binding]; other site 205920001023 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 205920001024 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 205920001025 30S ribosomal protein S13; Region: bact_S13; TIGR03631 205920001026 30S ribosomal protein S11; Validated; Region: PRK05309 205920001027 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 205920001028 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 205920001029 alphaNTD - beta interaction site [polypeptide binding]; other site 205920001030 alphaNTD homodimer interface [polypeptide binding]; other site 205920001031 alphaNTD - beta' interaction site [polypeptide binding]; other site 205920001032 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 205920001033 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 205920001034 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 205920001035 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 205920001036 putative tRNA-binding site [nucleotide binding]; other site 205920001037 B3/4 domain; Region: B3_4; pfam03483 205920001038 tRNA synthetase B5 domain; Region: B5; pfam03484 205920001039 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 205920001040 dimer interface [polypeptide binding]; other site 205920001041 motif 1; other site 205920001042 motif 3; other site 205920001043 motif 2; other site 205920001044 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 205920001045 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 205920001046 Competence protein; Region: Competence; pfam03772 205920001047 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 205920001048 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 205920001049 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 205920001050 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12847 205920001051 UbiA prenyltransferase family; Region: UbiA; pfam01040 205920001052 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 205920001053 dihydrodipicolinate reductase; Provisional; Region: PRK00048 205920001054 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 205920001055 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 205920001056 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14244 205920001057 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 205920001058 Walker A/P-loop; other site 205920001059 ATP binding site [chemical binding]; other site 205920001060 Q-loop/lid; other site 205920001061 ABC transporter signature motif; other site 205920001062 Walker B; other site 205920001063 D-loop; other site 205920001064 H-loop/switch region; other site 205920001065 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 205920001066 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 205920001067 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 205920001068 putative phosphate acyltransferase; Provisional; Region: PRK05331 205920001069 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 205920001070 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 205920001071 dimer interface [polypeptide binding]; other site 205920001072 active site 205920001073 CoA binding pocket [chemical binding]; other site 205920001074 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 205920001075 nucleoside/Zn binding site; other site 205920001076 dimer interface [polypeptide binding]; other site 205920001077 catalytic motif [active] 205920001078 replicative DNA helicase; Provisional; Region: PRK09165 205920001079 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 205920001080 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 205920001081 Walker A motif; other site 205920001082 ATP binding site [chemical binding]; other site 205920001083 Walker B motif; other site 205920001084 DNA binding loops [nucleotide binding] 205920001085 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 205920001086 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 205920001087 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 205920001088 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 205920001089 substrate binding pocket [chemical binding]; other site 205920001090 chain length determination region; other site 205920001091 substrate-Mg2+ binding site; other site 205920001092 catalytic residues [active] 205920001093 aspartate-rich region 1; other site 205920001094 active site lid residues [active] 205920001095 aspartate-rich region 2; other site 205920001096 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102 205920001097 Class I ribonucleotide reductase; Region: RNR_I; cd01679 205920001098 active site 205920001099 dimer interface [polypeptide binding]; other site 205920001100 catalytic residues [active] 205920001101 effector binding site; other site 205920001102 R2 peptide binding site; other site 205920001103 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 205920001104 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 205920001105 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 205920001106 GDP-binding site [chemical binding]; other site 205920001107 ACT binding site; other site 205920001108 IMP binding site; other site 205920001109 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 205920001110 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 205920001111 ligand binding site [chemical binding]; other site 205920001112 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 205920001113 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 205920001114 Zn binding site [ion binding]; other site 205920001115 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 205920001116 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 205920001117 TPP-binding site [chemical binding]; other site 205920001118 dimer interface [polypeptide binding]; other site 205920001119 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 205920001120 PYR/PP interface [polypeptide binding]; other site 205920001121 dimer interface [polypeptide binding]; other site 205920001122 TPP binding site [chemical binding]; other site 205920001123 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 205920001124 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12603 205920001125 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12670 205920001126 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 205920001127 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 205920001128 RNA binding site [nucleotide binding]; other site 205920001129 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 205920001130 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 205920001131 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 205920001132 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 205920001133 nucleotide binding site [chemical binding]; other site 205920001134 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 205920001135 putative coenzyme Q binding site [chemical binding]; other site 205920001136 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12664 205920001137 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 205920001138 signal recognition particle protein; Provisional; Region: PRK10867 205920001139 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 205920001140 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 205920001141 P loop; other site 205920001142 GTP binding site [chemical binding]; other site 205920001143 Signal peptide binding domain; Region: SRP_SPB; pfam02978 205920001144 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 205920001145 GTPase Era; Reviewed; Region: era; PRK00089 205920001146 G1 box; other site 205920001147 GTP/Mg2+ binding site [chemical binding]; other site 205920001148 Switch I region; other site 205920001149 G2 box; other site 205920001150 Switch II region; other site 205920001151 G3 box; other site 205920001152 G4 box; other site 205920001153 G5 box; other site 205920001154 KH domain; Region: KH_2; pfam07650 205920001155 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 205920001156 active site 205920001157 catalytic site [active] 205920001158 substrate binding site [chemical binding]; other site 205920001159 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 205920001160 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 205920001161 catalytic motif [active] 205920001162 Catalytic residue [active] 205920001163 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 205920001164 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 205920001165 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 205920001166 active site 205920001167 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 205920001168 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 205920001169 active site 205920001170 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 205920001171 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 205920001172 primosome assembly protein PriA; Validated; Region: PRK05580 205920001173 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205920001174 ATP binding site [chemical binding]; other site 205920001175 putative Mg++ binding site [ion binding]; other site 205920001176 helicase superfamily c-terminal domain; Region: HELICc; smart00490 205920001177 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 205920001178 diaminopimelate decarboxylase; Region: lysA; TIGR01048 205920001179 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 205920001180 active site 205920001181 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 205920001182 substrate binding site [chemical binding]; other site 205920001183 catalytic residues [active] 205920001184 dimer interface [polypeptide binding]; other site 205920001185 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 205920001186 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 205920001187 RNA binding surface [nucleotide binding]; other site 205920001188 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 205920001189 active site 205920001190 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 205920001191 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 205920001192 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 205920001193 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 205920001194 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 205920001195 carboxyltransferase (CT) interaction site; other site 205920001196 biotinylation site [posttranslational modification]; other site 205920001197 lipoyl synthase; Provisional; Region: PRK05481 205920001198 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 205920001199 FeS/SAM binding site; other site 205920001200 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 205920001201 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 205920001202 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205920001203 dimer interface [polypeptide binding]; other site 205920001204 conserved gate region; other site 205920001205 putative PBP binding loops; other site 205920001206 ABC-ATPase subunit interface; other site 205920001207 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 205920001208 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 205920001209 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 205920001210 type IV secretion system protein VirB3; Provisional; Region: PRK13899 205920001211 type IV secretion system ATPase VirB4; Provisional; Region: PRK13898 205920001212 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 205920001213 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205920001214 Walker A/P-loop; other site 205920001215 ATP binding site [chemical binding]; other site 205920001216 Q-loop/lid; other site 205920001217 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 205920001218 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 205920001219 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 205920001220 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 205920001221 Duffy-antigen binding protein; Region: DBP; pfam12361 205920001222 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 205920001223 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 205920001224 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 205920001225 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343 205920001226 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 205920001227 trimer interface [polypeptide binding]; other site 205920001228 active site 205920001229 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 205920001230 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 205920001231 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 205920001232 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 205920001233 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 205920001234 catalytic site [active] 205920001235 subunit interface [polypeptide binding]; other site 205920001236 GTP-binding protein Der; Reviewed; Region: PRK00093 205920001237 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 205920001238 G1 box; other site 205920001239 GTP/Mg2+ binding site [chemical binding]; other site 205920001240 Switch I region; other site 205920001241 G2 box; other site 205920001242 Switch II region; other site 205920001243 G3 box; other site 205920001244 G4 box; other site 205920001245 G5 box; other site 205920001246 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 205920001247 G1 box; other site 205920001248 GTP/Mg2+ binding site [chemical binding]; other site 205920001249 Switch I region; other site 205920001250 G2 box; other site 205920001251 G3 box; other site 205920001252 Switch II region; other site 205920001253 G4 box; other site 205920001254 G5 box; other site 205920001255 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 205920001256 phosphoglyceromutase; Provisional; Region: PRK05434 205920001257 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 205920001258 active site 205920001259 PQQ-like domain; Region: PQQ_2; pfam13360 205920001260 Trp docking motif [polypeptide binding]; other site 205920001261 PQQ-like domain; Region: PQQ_2; pfam13360 205920001262 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 205920001263 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 205920001264 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 205920001265 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 205920001266 HlyD family secretion protein; Region: HlyD_2; pfam12700 205920001267 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 205920001268 HlyD family secretion protein; Region: HlyD_3; pfam13437 205920001269 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 205920001270 rRNA binding site [nucleotide binding]; other site 205920001271 predicted 30S ribosome binding site; other site 205920001272 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 205920001273 active site 205920001274 dimer interface [polypeptide binding]; other site 205920001275 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 205920001276 rRNA interaction site [nucleotide binding]; other site 205920001277 S8 interaction site; other site 205920001278 putative laminin-1 binding site; other site 205920001279 elongation factor Ts; Provisional; Region: tsf; PRK09377 205920001280 UBA/TS-N domain; Region: UBA; pfam00627 205920001281 Elongation factor TS; Region: EF_TS; pfam00889 205920001282 Elongation factor TS; Region: EF_TS; pfam00889 205920001283 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 205920001284 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 205920001285 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 205920001286 ABC-ATPase subunit interface; other site 205920001287 dimer interface [polypeptide binding]; other site 205920001288 putative PBP binding regions; other site 205920001289 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 205920001290 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 205920001291 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 205920001292 [2Fe-2S] cluster binding site [ion binding]; other site 205920001293 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 205920001294 Qi binding site; other site 205920001295 intrachain domain interface; other site 205920001296 interchain domain interface [polypeptide binding]; other site 205920001297 cytochrome b; Provisional; Region: CYTB; MTH00156 205920001298 heme bH binding site [chemical binding]; other site 205920001299 heme bL binding site [chemical binding]; other site 205920001300 Qo binding site; other site 205920001301 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 205920001302 interchain domain interface [polypeptide binding]; other site 205920001303 intrachain domain interface; other site 205920001304 Qi binding site; other site 205920001305 Qo binding site; other site 205920001306 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 205920001307 thiamine monophosphate kinase; Provisional; Region: PRK05731 205920001308 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 205920001309 ATP binding site [chemical binding]; other site 205920001310 dimerization interface [polypeptide binding]; other site 205920001311 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 205920001312 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 205920001313 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 205920001314 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205920001315 Walker A motif; other site 205920001316 ATP binding site [chemical binding]; other site 205920001317 Walker B motif; other site 205920001318 arginine finger; other site 205920001319 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 205920001320 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 205920001321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205920001322 S-adenosylmethionine binding site [chemical binding]; other site 205920001323 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 205920001324 Recombination protein O N terminal; Region: RecO_N; pfam11967 205920001325 Recombination protein O C terminal; Region: RecO_C; pfam02565 205920001326 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 205920001327 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 205920001328 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 205920001329 active site 205920001330 HIGH motif; other site 205920001331 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 205920001332 KMSK motif region; other site 205920001333 tRNA binding surface [nucleotide binding]; other site 205920001334 DALR anticodon binding domain; Region: DALR_1; smart00836 205920001335 anticodon binding site; other site 205920001336 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 205920001337 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 205920001338 HIGH motif; other site 205920001339 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 205920001340 active site 205920001341 KMSKS motif; other site 205920001342 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 205920001343 tRNA binding surface [nucleotide binding]; other site 205920001344 anticodon binding site; other site 205920001345 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 205920001346 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 205920001347 catalytic triad [active] 205920001348 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 205920001349 RNA methyltransferase, RsmE family; Region: TIGR00046 205920001350 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 205920001351 MraW methylase family; Region: Methyltransf_5; cl17771 205920001352 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 205920001353 GTPase CgtA; Reviewed; Region: obgE; PRK12299 205920001354 GTP1/OBG; Region: GTP1_OBG; pfam01018 205920001355 Obg GTPase; Region: Obg; cd01898 205920001356 G1 box; other site 205920001357 GTP/Mg2+ binding site [chemical binding]; other site 205920001358 Switch I region; other site 205920001359 G2 box; other site 205920001360 G3 box; other site 205920001361 Switch II region; other site 205920001362 G4 box; other site 205920001363 G5 box; other site 205920001364 enolase; Provisional; Region: eno; PRK00077 205920001365 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 205920001366 dimer interface [polypeptide binding]; other site 205920001367 metal binding site [ion binding]; metal-binding site 205920001368 substrate binding pocket [chemical binding]; other site 205920001369 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 205920001370 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 205920001371 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 205920001372 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 205920001373 SLBB domain; Region: SLBB; pfam10531 205920001374 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 205920001375 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 205920001376 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 205920001377 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 205920001378 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 205920001379 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 205920001380 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 205920001381 NADH dehydrogenase subunit 5 C-terminus; Region: NADH5_C; pfam06455 205920001382 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 205920001383 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 205920001384 NADH dehydrogenase subunit 2; Validated; Region: ND2; MTH00041 205920001385 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 205920001386 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 205920001387 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 205920001388 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 205920001389 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 205920001390 MAEBL; Provisional; Region: PTZ00121 205920001391 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 205920001392 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 205920001393 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 205920001394 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 205920001395 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 205920001396 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 205920001397 NusA N-terminal domain; Region: NusA_N; pfam08529 205920001398 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 205920001399 RNA binding site [nucleotide binding]; other site 205920001400 homodimer interface [polypeptide binding]; other site 205920001401 NusA-like KH domain; Region: KH_5; pfam13184 205920001402 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 205920001403 G-X-X-G motif; other site 205920001404 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 205920001405 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 205920001406 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 205920001407 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 205920001408 G1 box; other site 205920001409 putative GEF interaction site [polypeptide binding]; other site 205920001410 GTP/Mg2+ binding site [chemical binding]; other site 205920001411 Switch I region; other site 205920001412 G2 box; other site 205920001413 G3 box; other site 205920001414 Switch II region; other site 205920001415 G4 box; other site 205920001416 G5 box; other site 205920001417 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 205920001418 Translation-initiation factor 2; Region: IF-2; pfam11987 205920001419 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 205920001420 Ribosome-binding factor A; Region: RBFA; pfam02033 205920001421 Integral membrane protein TerC family; Region: TerC; cl10468 205920001422 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 205920001423 Clp amino terminal domain; Region: Clp_N; pfam02861 205920001424 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205920001425 Walker A motif; other site 205920001426 ATP binding site [chemical binding]; other site 205920001427 Walker B motif; other site 205920001428 arginine finger; other site 205920001429 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 205920001430 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205920001431 Walker A motif; other site 205920001432 ATP binding site [chemical binding]; other site 205920001433 Walker B motif; other site 205920001434 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 205920001435 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 205920001436 MgtE intracellular N domain; Region: MgtE_N; smart00924 205920001437 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 205920001438 Divalent cation transporter; Region: MgtE; cl00786 205920001439 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 205920001440 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 205920001441 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 205920001442 alpha subunit interaction interface [polypeptide binding]; other site 205920001443 Walker A motif; other site 205920001444 ATP binding site [chemical binding]; other site 205920001445 Walker B motif; other site 205920001446 inhibitor binding site; inhibition site 205920001447 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 205920001448 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 205920001449 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; pfam02823 205920001450 gamma subunit interface [polypeptide binding]; other site 205920001451 epsilon subunit interface [polypeptide binding]; other site 205920001452 LBP interface [polypeptide binding]; other site 205920001453 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 205920001454 active site 205920001455 intersubunit interactions; other site 205920001456 catalytic residue [active] 205920001457 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 205920001458 RmuC family; Region: RmuC; pfam02646 205920001459 VirB8 protein; Region: VirB8; cl01500 205920001460 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 205920001461 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 205920001462 Protein chain release factor A [Translation, ribosomal structure and biogenesis]; Region: PrfA; COG0216 205920001463 seryl-tRNA synthetase; Provisional; Region: PRK05431 205920001464 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 205920001465 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 205920001466 dimer interface [polypeptide binding]; other site 205920001467 active site 205920001468 motif 1; other site 205920001469 motif 2; other site 205920001470 motif 3; other site 205920001471 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 205920001472 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 205920001473 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 205920001474 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 205920001475 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 205920001476 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752 205920001477 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752 205920001478 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 205920001479 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 205920001480 feedback inhibition sensing region; other site 205920001481 homohexameric interface [polypeptide binding]; other site 205920001482 nucleotide binding site [chemical binding]; other site 205920001483 N-acetyl-L-glutamate binding site [chemical binding]; other site 205920001484 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 205920001485 G1 box; other site 205920001486 GTP/Mg2+ binding site [chemical binding]; other site 205920001487 Switch I region; other site 205920001488 G2 box; other site 205920001489 G3 box; other site 205920001490 Switch II region; other site 205920001491 G4 box; other site 205920001492 G5 box; other site 205920001493 peptide chain release factor 1; Validated; Region: prfA; PRK00591 205920001494 This domain is found in peptide chain release factors; Region: PCRF; smart00937 205920001495 RF-1 domain; Region: RF-1; pfam00472 205920001496 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 205920001497 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 205920001498 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 205920001499 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 205920001500 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 205920001501 DNA binding site [nucleotide binding] 205920001502 catalytic residue [active] 205920001503 H2TH interface [polypeptide binding]; other site 205920001504 putative catalytic residues [active] 205920001505 turnover-facilitating residue; other site 205920001506 intercalation triad [nucleotide binding]; other site 205920001507 8OG recognition residue [nucleotide binding]; other site 205920001508 putative reading head residues; other site 205920001509 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 205920001510 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 205920001511 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 205920001512 active site 205920001513 HIGH motif; other site 205920001514 nucleotide binding site [chemical binding]; other site 205920001515 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 205920001516 active site 205920001517 KMSKS motif; other site 205920001518 Protein of unknown function (DUF3023); Region: DUF3023; pfam11224 205920001519 Protein of unknown function (DUF3023); Region: DUF3023; pfam11224 205920001520 Protein of unknown function (DUF3023); Region: DUF3023; pfam11224 205920001521 Protein of unknown function (DUF3023); Region: DUF3023; pfam11224 205920001522 NADH dehydrogenase subunit E; Validated; Region: PRK07539 205920001523 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 205920001524 putative dimer interface [polypeptide binding]; other site 205920001525 [2Fe-2S] cluster binding site [ion binding]; other site 205920001526 NADH dehydrogenase subunit D; Validated; Region: PRK06075 205920001527 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 205920001528 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 205920001529 NADH dehydrogenase subunit G; Validated; Region: PRK09130 205920001530 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 205920001531 catalytic loop [active] 205920001532 iron binding site [ion binding]; other site 205920001533 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 205920001534 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 205920001535 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 205920001536 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 205920001537 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205920001538 ATP binding site [chemical binding]; other site 205920001539 Mg2+ binding site [ion binding]; other site 205920001540 G-X-G motif; other site 205920001541 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 205920001542 anchoring element; other site 205920001543 dimer interface [polypeptide binding]; other site 205920001544 ATP binding site [chemical binding]; other site 205920001545 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 205920001546 active site 205920001547 putative metal-binding site [ion binding]; other site 205920001548 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 205920001549 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 205920001550 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 205920001551 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 205920001552 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 205920001553 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 205920001554 dimerization interface 3.5A [polypeptide binding]; other site 205920001555 active site 205920001556 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 205920001557 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 205920001558 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 205920001559 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 205920001560 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 205920001561 active site 205920001562 nucleotide binding site [chemical binding]; other site 205920001563 HIGH motif; other site 205920001564 KMSKS motif; other site 205920001565 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 205920001566 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 205920001567 Transcriptional regulator; Region: Rrf2; cl17282 205920001568 Predicted transcriptional regulator [Transcription]; Region: COG1959 205920001569 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 205920001570 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 205920001571 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 205920001572 catalytic residue [active] 205920001573 cysteine desulfurase; Provisional; Region: PRK14012 205920001574 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 205920001575 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 205920001576 catalytic residue [active] 205920001577 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 205920001578 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 205920001579 trimerization site [polypeptide binding]; other site 205920001580 active site 205920001581 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 205920001582 co-chaperone HscB; Provisional; Region: hscB; PRK05014 205920001583 DnaJ domain; Region: DnaJ; pfam00226 205920001584 HSP70 interaction site [polypeptide binding]; other site 205920001585 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 205920001586 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 205920001587 Fe-S protein assembly chaperone HscA; Region: HscA; TIGR01991 205920001588 nucleotide binding site [chemical binding]; other site 205920001589 putative NEF/HSP70 interaction site [polypeptide binding]; other site 205920001590 SBD interface [polypeptide binding]; other site 205920001591 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 205920001592 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 205920001593 catalytic loop [active] 205920001594 iron binding site [ion binding]; other site 205920001595 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 205920001596 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 205920001597 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205920001598 S-adenosylmethionine binding site [chemical binding]; other site 205920001599 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 205920001600 malate dehydrogenase; Reviewed; Region: PRK06223 205920001601 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 205920001602 NAD(P) binding site [chemical binding]; other site 205920001603 dimer interface [polypeptide binding]; other site 205920001604 tetramer (dimer of dimers) interface [polypeptide binding]; other site 205920001605 substrate binding site [chemical binding]; other site 205920001606 Dihydroneopterin aldolase; Region: FolB; smart00905 205920001607 active site 205920001608 RDD family; Region: RDD; pfam06271 205920001609 UGMP family protein; Validated; Region: PRK09604 205920001610 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 205920001611 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 205920001612 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 205920001613 triosephosphate isomerase; Provisional; Region: PRK14565 205920001614 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 205920001615 substrate binding site [chemical binding]; other site 205920001616 dimer interface [polypeptide binding]; other site 205920001617 catalytic triad [active] 205920001618 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 205920001619 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205920001620 S-adenosylmethionine binding site [chemical binding]; other site 205920001621 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 205920001622 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 205920001623 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 205920001624 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 205920001625 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 205920001626 GTP cyclohydrolase I; Provisional; Region: PLN03044 205920001627 active site 205920001628 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 205920001629 core domain interface [polypeptide binding]; other site 205920001630 delta subunit interface [polypeptide binding]; other site 205920001631 epsilon subunit interface [polypeptide binding]; other site 205920001632 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 205920001633 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 205920001634 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 205920001635 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 205920001636 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 205920001637 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 205920001638 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 205920001639 30S subunit binding site; other site 205920001640 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 205920001641 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 205920001642 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 205920001643 DNA binding residues [nucleotide binding] 205920001644 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 205920001645 phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215 205920001646 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 205920001647 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 205920001648 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 205920001649 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 205920001650 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 205920001651 inhibitor-cofactor binding pocket; inhibition site 205920001652 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205920001653 catalytic residue [active] 205920001654 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 205920001655 Proline dehydrogenase; Region: Pro_dh; pfam01619 205920001656 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 205920001657 Glutamate binding site [chemical binding]; other site 205920001658 NAD binding site [chemical binding]; other site 205920001659 catalytic residues [active] 205920001660 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 205920001661 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 205920001662 NAD(P) binding site [chemical binding]; other site 205920001663 homotetramer interface [polypeptide binding]; other site 205920001664 homodimer interface [polypeptide binding]; other site 205920001665 active site 205920001666 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 205920001667 putative catalytic site [active] 205920001668 putative phosphate binding site [ion binding]; other site 205920001669 active site 205920001670 metal binding site A [ion binding]; metal-binding site 205920001671 DNA binding site [nucleotide binding] 205920001672 putative AP binding site [nucleotide binding]; other site 205920001673 putative metal binding site B [ion binding]; other site 205920001674 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 205920001675 heterotetramer interface [polypeptide binding]; other site 205920001676 active site pocket [active] 205920001677 cleavage site 205920001678 argininosuccinate synthase; Provisional; Region: PRK13820 205920001679 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 205920001680 ANP binding site [chemical binding]; other site 205920001681 Substrate Binding Site II [chemical binding]; other site 205920001682 Substrate Binding Site I [chemical binding]; other site 205920001683 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 205920001684 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 205920001685 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 205920001686 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 205920001687 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 205920001688 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 205920001689 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 205920001690 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 205920001691 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 205920001692 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 205920001693 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 205920001694 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 205920001695 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 205920001696 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 205920001697 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 205920001698 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 205920001699 Zn2+ binding site [ion binding]; other site 205920001700 Mg2+ binding site [ion binding]; other site 205920001701 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 205920001702 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 205920001703 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 205920001704 Catalytic site [active] 205920001705 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 205920001706 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 205920001707 4Fe-4S binding domain; Region: Fer4; pfam00037 205920001708 4Fe-4S binding domain; Region: Fer4; pfam00037 205920001709 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 205920001710 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 205920001711 G1 box; other site 205920001712 putative GEF interaction site [polypeptide binding]; other site 205920001713 GTP/Mg2+ binding site [chemical binding]; other site 205920001714 Switch I region; other site 205920001715 G2 box; other site 205920001716 G3 box; other site 205920001717 Switch II region; other site 205920001718 G4 box; other site 205920001719 G5 box; other site 205920001720 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 205920001721 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 205920001722 Protein of unknown function (DUF3023); Region: DUF3023; pfam11224 205920001723 Protein of unknown function (DUF3023); Region: DUF3023; pfam11224 205920001724 Protein of unknown function (DUF3023); Region: DUF3023; pfam11224 205920001725 Protein of unknown function (DUF3023); Region: DUF3023; pfam11224 205920001726 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 205920001727 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 205920001728 domain interfaces; other site 205920001729 active site 205920001730 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 205920001731 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 205920001732 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 205920001733 hypothetical protein; Validated; Region: PRK00110 205920001734 peptide chain release factor 2; Validated; Region: prfB; PRK00578 205920001735 This domain is found in peptide chain release factors; Region: PCRF; smart00937 205920001736 RF-1 domain; Region: RF-1; pfam00472 205920001737 Protein of unknown function (DUF721); Region: DUF721; cl02324 205920001738 Protein of unknown function (DUF721); Region: DUF721; cl02324 205920001739 Protein of unknown function (DUF1240); Region: DUF1240; pfam06836 205920001740 GTP-binding protein LepA; Provisional; Region: PRK05433 205920001741 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 205920001742 G1 box; other site 205920001743 putative GEF interaction site [polypeptide binding]; other site 205920001744 GTP/Mg2+ binding site [chemical binding]; other site 205920001745 Switch I region; other site 205920001746 G2 box; other site 205920001747 G3 box; other site 205920001748 Switch II region; other site 205920001749 G4 box; other site 205920001750 G5 box; other site 205920001751 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 205920001752 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 205920001753 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 205920001754 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 205920001755 Methyltransferase domain; Region: Methyltransf_11; pfam08241 205920001756 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 205920001757 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 205920001758 RNase E interface [polypeptide binding]; other site 205920001759 trimer interface [polypeptide binding]; other site 205920001760 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 205920001761 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 205920001762 RNase E interface [polypeptide binding]; other site 205920001763 trimer interface [polypeptide binding]; other site 205920001764 active site 205920001765 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 205920001766 putative nucleic acid binding region [nucleotide binding]; other site 205920001767 G-X-X-G motif; other site 205920001768 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 205920001769 RNA binding site [nucleotide binding]; other site 205920001770 domain interface; other site 205920001771 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 205920001772 16S/18S rRNA binding site [nucleotide binding]; other site 205920001773 S13e-L30e interaction site [polypeptide binding]; other site 205920001774 25S rRNA binding site [nucleotide binding]; other site 205920001775 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 205920001776 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 205920001777 RNA binding site [nucleotide binding]; other site 205920001778 active site 205920001779 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 205920001780 Glycoprotease family; Region: Peptidase_M22; pfam00814 205920001781 periplasmic folding chaperone; Provisional; Region: PRK10788 205920001782 SurA N-terminal domain; Region: SurA_N_3; cl07813 205920001783 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 205920001784 aspartate aminotransferase; Provisional; Region: PRK05764 205920001785 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205920001786 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205920001787 homodimer interface [polypeptide binding]; other site 205920001788 catalytic residue [active] 205920001789 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 205920001790 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 205920001791 dimer interface [polypeptide binding]; other site 205920001792 decamer (pentamer of dimers) interface [polypeptide binding]; other site 205920001793 catalytic triad [active] 205920001794 peroxidatic and resolving cysteines [active] 205920001795 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 205920001796 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 205920001797 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 205920001798 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 205920001799 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 205920001800 active site 205920001801 (T/H)XGH motif; other site 205920001802 Peptidase C26; Region: Peptidase_C26; pfam07722 205920001803 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 205920001804 prolyl-tRNA synthetase; Provisional; Region: PRK12325 205920001805 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 205920001806 dimer interface [polypeptide binding]; other site 205920001807 motif 1; other site 205920001808 active site 205920001809 motif 2; other site 205920001810 motif 3; other site 205920001811 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 205920001812 anticodon binding site; other site 205920001813 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK14659 205920001814 Stringent starvation protein B; Region: SspB; pfam04386 205920001815 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 205920001816 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 205920001817 DNA topoisomerase I; Validated; Region: PRK06599 205920001818 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 205920001819 active site 205920001820 interdomain interaction site; other site 205920001821 putative metal-binding site [ion binding]; other site 205920001822 nucleotide binding site [chemical binding]; other site 205920001823 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 205920001824 domain I; other site 205920001825 DNA binding groove [nucleotide binding] 205920001826 phosphate binding site [ion binding]; other site 205920001827 domain II; other site 205920001828 domain III; other site 205920001829 nucleotide binding site [chemical binding]; other site 205920001830 catalytic site [active] 205920001831 domain IV; other site 205920001832 Uncharacterized C-terminal domain of topoisomerase IA [General function prediction only]; Region: COG1754 205920001833 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 205920001834 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 205920001835 putative carbohydrate kinase; Provisional; Region: PRK10565 205920001836 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 205920001837 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 205920001838 putative substrate binding site [chemical binding]; other site 205920001839 putative ATP binding site [chemical binding]; other site 205920001840 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 205920001841 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 205920001842 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205920001843 dimer interface [polypeptide binding]; other site 205920001844 phosphorylation site [posttranslational modification] 205920001845 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205920001846 ATP binding site [chemical binding]; other site 205920001847 Mg2+ binding site [ion binding]; other site 205920001848 G-X-G motif; other site 205920001849 Response regulator receiver domain; Region: Response_reg; pfam00072 205920001850 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205920001851 active site 205920001852 phosphorylation site [posttranslational modification] 205920001853 intermolecular recognition site; other site 205920001854 dimerization interface [polypeptide binding]; other site 205920001855 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 205920001856 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14610 205920001857 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 205920001858 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 205920001859 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 205920001860 FMN binding site [chemical binding]; other site 205920001861 active site 205920001862 catalytic residues [active] 205920001863 substrate binding site [chemical binding]; other site 205920001864 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 205920001865 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 205920001866 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 205920001867 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 205920001868 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 205920001869 DNA binding residues [nucleotide binding] 205920001870 DNA primase; Validated; Region: dnaG; PRK05667 205920001871 CHC2 zinc finger; Region: zf-CHC2; cl17510 205920001872 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 205920001873 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 205920001874 active site 205920001875 metal binding site [ion binding]; metal-binding site 205920001876 interdomain interaction site; other site 205920001877 Uncharacterized conserved protein [Function unknown]; Region: COG1565 205920001878 Domain of unknown function (DUF2610); Region: DUF2610; pfam11020 205920001879 Domain of unknown function (DUF2610); Region: DUF2610; pfam11020 205920001880 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 205920001881 dimer interface [polypeptide binding]; other site 205920001882 putative radical transfer pathway; other site 205920001883 diiron center [ion binding]; other site 205920001884 tyrosyl radical; other site 205920001885 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 205920001886 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 205920001887 active site 205920001888 HIGH motif; other site 205920001889 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 205920001890 KMSKS motif; other site 205920001891 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 205920001892 tRNA binding surface [nucleotide binding]; other site 205920001893 anticodon binding site; other site 205920001894 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 205920001895 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 205920001896 response regulator PleD; Reviewed; Region: pleD; PRK09581 205920001897 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205920001898 active site 205920001899 phosphorylation site [posttranslational modification] 205920001900 intermolecular recognition site; other site 205920001901 dimerization interface [polypeptide binding]; other site 205920001902 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205920001903 active site 205920001904 phosphorylation site [posttranslational modification] 205920001905 intermolecular recognition site; other site 205920001906 dimerization interface [polypeptide binding]; other site 205920001907 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205920001908 metal binding site [ion binding]; metal-binding site 205920001909 active site 205920001910 I-site; other site 205920001911 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 205920001912 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 205920001913 active site 205920001914 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 205920001915 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 205920001916 active site 205920001917 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 205920001918 elongation factor P; Validated; Region: PRK00529 205920001919 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 205920001920 RNA binding site [nucleotide binding]; other site 205920001921 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 205920001922 RNA binding site [nucleotide binding]; other site 205920001923 putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; Validated; Region: PRK06567 205920001924 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 205920001925 FAD binding pocket [chemical binding]; other site 205920001926 FAD binding motif [chemical binding]; other site 205920001927 phosphate binding motif [ion binding]; other site 205920001928 beta-alpha-beta structure motif; other site 205920001929 NAD binding pocket [chemical binding]; other site 205920001930 Iron coordination center [ion binding]; other site 205920001931 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 205920001932 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 205920001933 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 205920001934 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 205920001935 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 205920001936 membrane protein insertase; Provisional; Region: PRK01318 205920001937 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 205920001938 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 205920001939 homopentamer interface [polypeptide binding]; other site 205920001940 active site 205920001941 transcription antitermination factor NusB; Region: nusB; TIGR01951 205920001942 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 205920001943 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 205920001944 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 205920001945 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 205920001946 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 205920001947 NADH dehydrogenase subunit B; Validated; Region: PRK06411 205920001948 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 205920001949 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 205920001950 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 205920001951 Survival protein SurE; Region: SurE; cl00448 205920001952 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 205920001953 active site 205920001954 dimer interface [polypeptide binding]; other site 205920001955 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 205920001956 active site 205920001957 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 205920001958 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 205920001959 HIGH motif; other site 205920001960 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 205920001961 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 205920001962 active site 205920001963 KMSKS motif; other site 205920001964 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 205920001965 tRNA binding surface [nucleotide binding]; other site 205920001966 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 205920001967 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 205920001968 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 205920001969 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 205920001970 Smr domain; Region: Smr; pfam01713 205920001971 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 205920001972 ThiC-associated domain; Region: ThiC-associated; pfam13667 205920001973 ThiC family; Region: ThiC; pfam01964 205920001974 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 205920001975 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 205920001976 CoA-binding site [chemical binding]; other site 205920001977 ATP-binding [chemical binding]; other site 205920001978 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 205920001979 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 205920001980 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205920001981 Walker A motif; other site 205920001982 ATP binding site [chemical binding]; other site 205920001983 Walker B motif; other site 205920001984 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 205920001985 IHF dimer interface [polypeptide binding]; other site 205920001986 IHF - DNA interface [nucleotide binding]; other site 205920001987 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 205920001988 active site 205920001989 hydrophilic channel; other site 205920001990 dimerization interface [polypeptide binding]; other site 205920001991 catalytic residues [active] 205920001992 active site lid [active] 205920001993 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 205920001994 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 205920001995 active site 205920001996 (T/H)XGH motif; other site 205920001997 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 205920001998 DnaA N-terminal domain; Region: DnaA_N; pfam11638 205920001999 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205920002000 Walker A motif; other site 205920002001 ATP binding site [chemical binding]; other site 205920002002 Walker B motif; other site 205920002003 arginine finger; other site 205920002004 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 205920002005 DnaA box-binding interface [nucleotide binding]; other site 205920002006 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 205920002007 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 205920002008 NAD binding site [chemical binding]; other site 205920002009 homotetramer interface [polypeptide binding]; other site 205920002010 homodimer interface [polypeptide binding]; other site 205920002011 substrate binding site [chemical binding]; other site 205920002012 active site 205920002013 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 205920002014 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 205920002015 GatB domain; Region: GatB_Yqey; smart00845 205920002016 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 205920002017 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 205920002018 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 205920002019 dimer interface [polypeptide binding]; other site 205920002020 ssDNA binding site [nucleotide binding]; other site 205920002021 tetramer (dimer of dimers) interface [polypeptide binding]; other site 205920002022 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 205920002023 metabolite-proton symporter; Region: 2A0106; TIGR00883 205920002024 putative substrate translocation pore; other site 205920002025 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205920002026 metabolite-proton symporter; Region: 2A0106; TIGR00883 205920002027 putative substrate translocation pore; other site 205920002028 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 205920002029 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 205920002030 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 205920002031 dimer interface [polypeptide binding]; other site 205920002032 allosteric magnesium binding site [ion binding]; other site 205920002033 active site 205920002034 aspartate-rich active site metal binding site; other site 205920002035 Schiff base residues; other site 205920002036 NAD synthetase; Provisional; Region: PRK13981 205920002037 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 205920002038 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 205920002039 homodimer interface [polypeptide binding]; other site 205920002040 NAD binding pocket [chemical binding]; other site 205920002041 ATP binding pocket [chemical binding]; other site 205920002042 Mg binding site [ion binding]; other site 205920002043 active-site loop [active] 205920002044 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 205920002045 MutS domain I; Region: MutS_I; pfam01624 205920002046 MutS domain II; Region: MutS_II; pfam05188 205920002047 MutS domain III; Region: MutS_III; pfam05192 205920002048 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 205920002049 Walker A/P-loop; other site 205920002050 ATP binding site [chemical binding]; other site 205920002051 Q-loop/lid; other site 205920002052 ABC transporter signature motif; other site 205920002053 Walker B; other site 205920002054 D-loop; other site 205920002055 H-loop/switch region; other site 205920002056 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 205920002057 nucleotide binding site/active site [active] 205920002058 HIT family signature motif; other site 205920002059 catalytic residue [active] 205920002060 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 205920002061 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 205920002062 dimer interface [polypeptide binding]; other site 205920002063 active site 205920002064 catalytic residue [active] 205920002065 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 205920002066 Phage capsid family; Region: Phage_capsid; pfam05065 205920002067 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 205920002068 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 205920002069 TPP-binding site [chemical binding]; other site 205920002070 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 205920002071 dimer interface [polypeptide binding]; other site 205920002072 PYR/PP interface [polypeptide binding]; other site 205920002073 TPP binding site [chemical binding]; other site 205920002074 Uncharacterized conserved protein [Function unknown]; Region: COG5449 205920002075 Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931 205920002076 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 205920002077 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 205920002078 Putative phage tail protein; Region: Phage-tail_3; pfam13550 205920002079 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 205920002080 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 205920002081 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 205920002082 FeS/SAM binding site; other site 205920002083 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205920002084 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205920002085 putative substrate translocation pore; other site 205920002086 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 205920002087 ABC1 family; Region: ABC1; pfam03109 205920002088 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 205920002089 active site 205920002090 ATP binding site [chemical binding]; other site 205920002091 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 205920002092 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205920002093 Walker A/P-loop; other site 205920002094 ATP binding site [chemical binding]; other site 205920002095 Q-loop/lid; other site 205920002096 ABC transporter signature motif; other site 205920002097 Walker B; other site 205920002098 D-loop; other site 205920002099 H-loop/switch region; other site 205920002100 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 205920002101 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 205920002102 metal binding site [ion binding]; metal-binding site 205920002103 recombination protein RecR; Reviewed; Region: recR; PRK00076 205920002104 RecR protein; Region: RecR; pfam02132 205920002105 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 205920002106 putative active site [active] 205920002107 putative metal-binding site [ion binding]; other site 205920002108 tetramer interface [polypeptide binding]; other site 205920002109 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 205920002110 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 205920002111 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 205920002112 Walker A/P-loop; other site 205920002113 ATP binding site [chemical binding]; other site 205920002114 Q-loop/lid; other site 205920002115 ABC transporter signature motif; other site 205920002116 Walker B; other site 205920002117 D-loop; other site 205920002118 H-loop/switch region; other site 205920002119 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 205920002120 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 205920002121 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 205920002122 C-terminal domain interface [polypeptide binding]; other site 205920002123 GSH binding site (G-site) [chemical binding]; other site 205920002124 dimer interface [polypeptide binding]; other site 205920002125 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 205920002126 N-terminal domain interface [polypeptide binding]; other site 205920002127 dimer interface [polypeptide binding]; other site 205920002128 substrate binding pocket (H-site) [chemical binding]; other site 205920002129 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 205920002130 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 205920002131 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 205920002132 adenylosuccinate lyase; Provisional; Region: PRK07492 205920002133 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 205920002134 tetramer interface [polypeptide binding]; other site 205920002135 active site 205920002136 heat shock protein 90; Provisional; Region: PRK05218 205920002137 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205920002138 ATP binding site [chemical binding]; other site 205920002139 Mg2+ binding site [ion binding]; other site 205920002140 G-X-G motif; other site 205920002141 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 205920002142 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 205920002143 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 205920002144 minor groove reading motif; other site 205920002145 helix-hairpin-helix signature motif; other site 205920002146 substrate binding pocket [chemical binding]; other site 205920002147 active site 205920002148 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 205920002149 DNA gyrase subunit A; Validated; Region: PRK05560 205920002150 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 205920002151 CAP-like domain; other site 205920002152 active site 205920002153 primary dimer interface [polypeptide binding]; other site 205920002154 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 205920002155 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 205920002156 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 205920002157 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 205920002158 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 205920002159 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 205920002160 Part of AAA domain; Region: AAA_19; pfam13245 205920002161 Family description; Region: UvrD_C_2; pfam13538 205920002162 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 205920002163 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 205920002164 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 205920002165 Walker A motif; other site 205920002166 ATP binding site [chemical binding]; other site 205920002167 Walker B motif; other site 205920002168 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 205920002169 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 205920002170 Ligand Binding Site [chemical binding]; other site 205920002171 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 205920002172 diiron binding motif [ion binding]; other site 205920002173 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 205920002174 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 205920002175 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 205920002176 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 205920002177 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 205920002178 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 205920002179 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 205920002180 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 205920002181 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 205920002182 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 205920002183 acyl carrier protein; Provisional; Region: acpP; PRK00982 205920002184 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 205920002185 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 205920002186 dimer interface [polypeptide binding]; other site 205920002187 active site 205920002188 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 205920002189 DNA protecting protein DprA; Region: dprA; TIGR00732 205920002190 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 205920002191 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205920002192 ATP binding site [chemical binding]; other site 205920002193 Mg2+ binding site [ion binding]; other site 205920002194 G-X-G motif; other site 205920002195 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 205920002196 ATP binding site [chemical binding]; other site 205920002197 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 205920002198 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 205920002199 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205920002200 dimer interface [polypeptide binding]; other site 205920002201 phosphorylation site [posttranslational modification] 205920002202 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205920002203 ATP binding site [chemical binding]; other site 205920002204 Mg2+ binding site [ion binding]; other site 205920002205 G-X-G motif; other site 205920002206 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 205920002207 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 205920002208 inhibitor-cofactor binding pocket; inhibition site 205920002209 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205920002210 catalytic residue [active] 205920002211 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 205920002212 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 205920002213 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 205920002214 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 205920002215 Domain of unknown function DUF21; Region: DUF21; pfam01595 205920002216 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 205920002217 Transporter associated domain; Region: CorC_HlyC; smart01091 205920002218 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 205920002219 thiamine phosphate binding site [chemical binding]; other site 205920002220 active site 205920002221 pyrophosphate binding site [ion binding]; other site 205920002222 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 205920002223 PEP synthetase regulatory protein; Provisional; Region: PRK05339 205920002224 hypothetical protein; Validated; Region: PRK01415 205920002225 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 205920002226 active site residue [active] 205920002227 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 205920002228 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 205920002229 putative active site [active] 205920002230 substrate binding site [chemical binding]; other site 205920002231 putative cosubstrate binding site; other site 205920002232 catalytic site [active] 205920002233 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 205920002234 substrate binding site [chemical binding]; other site 205920002235 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 205920002236 Found in ATP-dependent protease La (LON); Region: LON; smart00464 205920002237 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205920002238 Walker A motif; other site 205920002239 ATP binding site [chemical binding]; other site 205920002240 Walker B motif; other site 205920002241 arginine finger; other site 205920002242 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 205920002243 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 205920002244 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 205920002245 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205920002246 Walker A motif; other site 205920002247 ATP binding site [chemical binding]; other site 205920002248 Walker B motif; other site 205920002249 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 205920002250 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 205920002251 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 205920002252 oligomer interface [polypeptide binding]; other site 205920002253 active site residues [active] 205920002254 trigger factor; Region: tig; TIGR00115 205920002255 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 205920002256 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 205920002257 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 205920002258 tetramer interfaces [polypeptide binding]; other site 205920002259 binuclear metal-binding site [ion binding]; other site 205920002260 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 205920002261 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205920002262 Coenzyme A binding pocket [chemical binding]; other site 205920002263 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 205920002264 Domain of unknown function DUF20; Region: UPF0118; pfam01594 205920002265 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 205920002266 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 205920002267 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 205920002268 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 205920002269 RNA binding surface [nucleotide binding]; other site 205920002270 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 205920002271 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 205920002272 Walker A motif; other site 205920002273 ATP binding site [chemical binding]; other site 205920002274 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 205920002275 dimer interface [polypeptide binding]; other site 205920002276 substrate binding site [chemical binding]; other site 205920002277 ATP binding site [chemical binding]; other site 205920002278 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 205920002279 putative SdhC subunit interface [polypeptide binding]; other site 205920002280 putative proximal heme binding site [chemical binding]; other site 205920002281 putative Iron-sulfur protein interface [polypeptide binding]; other site 205920002282 putative proximal quinone binding site; other site 205920002283 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 205920002284 Iron-sulfur protein interface; other site 205920002285 proximal quinone binding site [chemical binding]; other site 205920002286 SdhD (CybS) interface [polypeptide binding]; other site 205920002287 proximal heme binding site [chemical binding]; other site 205920002288 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 205920002289 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 205920002290 putative active site [active] 205920002291 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 205920002292 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 205920002293 putative active site [active] 205920002294 putative PHP Thumb interface [polypeptide binding]; other site 205920002295 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 205920002296 generic binding surface II; other site 205920002297 generic binding surface I; other site 205920002298 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 205920002299 BolA-like protein; Region: BolA; pfam01722 205920002300 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 205920002301 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 205920002302 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 205920002303 putative hydrolase; Provisional; Region: PRK11460 205920002304 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 205920002305 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 205920002306 argininosuccinate lyase; Provisional; Region: PRK00855 205920002307 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 205920002308 active sites [active] 205920002309 tetramer interface [polypeptide binding]; other site 205920002310 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 205920002311 active site 205920002312 catalytic residues [active] 205920002313 metal binding site [ion binding]; metal-binding site 205920002314 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 205920002315 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 205920002316 quinone interaction residues [chemical binding]; other site 205920002317 active site 205920002318 catalytic residues [active] 205920002319 FMN binding site [chemical binding]; other site 205920002320 substrate binding site [chemical binding]; other site 205920002321 pantothenate kinase; Reviewed; Region: PRK13318 205920002322 Uncharacterized conserved protein [Function unknown]; Region: COG3334 205920002323 Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899 205920002324 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 205920002325 RNA/DNA hybrid binding site [nucleotide binding]; other site 205920002326 active site 205920002327 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 205920002328 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 205920002329 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 205920002330 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 205920002331 catalytic residue [active] 205920002332 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 205920002333 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 205920002334 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 205920002335 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 205920002336 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 205920002337 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 205920002338 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 205920002339 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 205920002340 DNA binding site [nucleotide binding] 205920002341 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 205920002342 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 205920002343 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 205920002344 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 205920002345 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 205920002346 RPB12 interaction site [polypeptide binding]; other site 205920002347 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 205920002348 RPB3 interaction site [polypeptide binding]; other site 205920002349 RPB1 interaction site [polypeptide binding]; other site 205920002350 RPB11 interaction site [polypeptide binding]; other site 205920002351 RPB10 interaction site [polypeptide binding]; other site 205920002352 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 205920002353 peripheral dimer interface [polypeptide binding]; other site 205920002354 core dimer interface [polypeptide binding]; other site 205920002355 L10 interface [polypeptide binding]; other site 205920002356 L11 interface [polypeptide binding]; other site 205920002357 putative EF-Tu interaction site [polypeptide binding]; other site 205920002358 putative EF-G interaction site [polypeptide binding]; other site 205920002359 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 205920002360 23S rRNA interface [nucleotide binding]; other site 205920002361 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 205920002362 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 205920002363 mRNA/rRNA interface [nucleotide binding]; other site 205920002364 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 205920002365 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 205920002366 23S rRNA interface [nucleotide binding]; other site 205920002367 L7/L12 interface [polypeptide binding]; other site 205920002368 putative thiostrepton binding site; other site 205920002369 L25 interface [polypeptide binding]; other site 205920002370 transcription termination/antitermination factor NusG; Region: nusG; TIGR00922 205920002371 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 205920002372 putative homodimer interface [polypeptide binding]; other site 205920002373 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 205920002374 heterodimer interface [polypeptide binding]; other site 205920002375 homodimer interface [polypeptide binding]; other site 205920002376 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 205920002377 elongation factor Tu; Reviewed; Region: PRK00049 205920002378 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 205920002379 G1 box; other site 205920002380 GEF interaction site [polypeptide binding]; other site 205920002381 GTP/Mg2+ binding site [chemical binding]; other site 205920002382 Switch I region; other site 205920002383 G2 box; other site 205920002384 G3 box; other site 205920002385 Switch II region; other site 205920002386 G4 box; other site 205920002387 G5 box; other site 205920002388 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 205920002389 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 205920002390 Antibiotic Binding Site [chemical binding]; other site 205920002391 elongation factor G; Reviewed; Region: PRK00007 205920002392 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 205920002393 G1 box; other site 205920002394 putative GEF interaction site [polypeptide binding]; other site 205920002395 GTP/Mg2+ binding site [chemical binding]; other site 205920002396 Switch I region; other site 205920002397 G2 box; other site 205920002398 G3 box; other site 205920002399 Switch II region; other site 205920002400 G4 box; other site 205920002401 G5 box; other site 205920002402 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 205920002403 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 205920002404 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 205920002405 30S ribosomal protein S7; Validated; Region: PRK05302 205920002406 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 205920002407 S17 interaction site [polypeptide binding]; other site 205920002408 S8 interaction site; other site 205920002409 16S rRNA interaction site [nucleotide binding]; other site 205920002410 streptomycin interaction site [chemical binding]; other site 205920002411 23S rRNA interaction site [nucleotide binding]; other site 205920002412 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 205920002413 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 205920002414 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 205920002415 active site 205920002416 metal binding site [ion binding]; metal-binding site 205920002417 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 205920002418 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 205920002419 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 205920002420 rpsU-divergently transcribed protein; Region: diverge_rpsU; TIGR02396 205920002421 COQ9; Region: COQ9; pfam08511 205920002422 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 205920002423 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467; cl01853 205920002424 HlyD family secretion protein; Region: HlyD_3; pfam13437 205920002425 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 205920002426 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205920002427 dimer interface [polypeptide binding]; other site 205920002428 conserved gate region; other site 205920002429 putative PBP binding loops; other site 205920002430 ABC-ATPase subunit interface; other site 205920002431 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 205920002432 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 205920002433 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 205920002434 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 205920002435 FMN binding site [chemical binding]; other site 205920002436 substrate binding site [chemical binding]; other site 205920002437 putative catalytic residue [active] 205920002438 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 205920002439 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 205920002440 Cu(I) binding site [ion binding]; other site 205920002441 PBP superfamily domain; Region: PBP_like_2; cl17296 205920002442 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 205920002443 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 205920002444 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 205920002445 CoA-ligase; Region: Ligase_CoA; pfam00549 205920002446 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 205920002447 CoA binding domain; Region: CoA_binding; smart00881 205920002448 CoA-ligase; Region: Ligase_CoA; pfam00549 205920002449 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 205920002450 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 205920002451 motif 1; other site 205920002452 active site 205920002453 motif 2; other site 205920002454 motif 3; other site 205920002455 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 205920002456 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 205920002457 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205920002458 dimer interface [polypeptide binding]; other site 205920002459 conserved gate region; other site 205920002460 putative PBP binding loops; other site 205920002461 ABC-ATPase subunit interface; other site 205920002462 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 205920002463 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 205920002464 putative hydrolase; Provisional; Region: PRK02113 205920002465 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 205920002466 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 205920002467 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 205920002468 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 205920002469 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 205920002470 transcription termination factor Rho; Provisional; Region: rho; PRK09376 205920002471 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 205920002472 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 205920002473 RNA binding site [nucleotide binding]; other site 205920002474 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 205920002475 multimer interface [polypeptide binding]; other site 205920002476 Walker A motif; other site 205920002477 ATP binding site [chemical binding]; other site 205920002478 Walker B motif; other site 205920002479 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 205920002480 active site 205920002481 HslU subunit interaction site [polypeptide binding]; other site 205920002482 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 205920002483 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205920002484 Walker A motif; other site 205920002485 ATP binding site [chemical binding]; other site 205920002486 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 205920002487 Walker B motif; other site 205920002488 arginine finger; other site 205920002489 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 205920002490 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 205920002491 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205920002492 S-adenosylmethionine binding site [chemical binding]; other site 205920002493 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 205920002494 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 205920002495 active site 205920002496 HIGH motif; other site 205920002497 KMSKS motif; other site 205920002498 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 205920002499 tRNA binding surface [nucleotide binding]; other site 205920002500 anticodon binding site; other site 205920002501 aspartate kinase; Reviewed; Region: PRK06635 205920002502 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 205920002503 putative nucleotide binding site [chemical binding]; other site 205920002504 putative catalytic residues [active] 205920002505 putative Mg ion binding site [ion binding]; other site 205920002506 putative aspartate binding site [chemical binding]; other site 205920002507 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 205920002508 putative allosteric regulatory site; other site 205920002509 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 205920002510 putative allosteric regulatory residue; other site 205920002511 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 205920002512 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140 205920002513 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 205920002514 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 205920002515 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 205920002516 Subunit I/III interface [polypeptide binding]; other site 205920002517 D-pathway; other site 205920002518 Subunit I/VIIc interface [polypeptide binding]; other site 205920002519 Subunit I/IV interface [polypeptide binding]; other site 205920002520 Subunit I/II interface [polypeptide binding]; other site 205920002521 Low-spin heme (heme a) binding site [chemical binding]; other site 205920002522 Subunit I/VIIa interface [polypeptide binding]; other site 205920002523 Subunit I/VIa interface [polypeptide binding]; other site 205920002524 Dimer interface; other site 205920002525 Putative water exit pathway; other site 205920002526 Binuclear center (heme a3/CuB) [ion binding]; other site 205920002527 K-pathway; other site 205920002528 Subunit I/Vb interface [polypeptide binding]; other site 205920002529 Putative proton exit pathway; other site 205920002530 Subunit I/VIb interface; other site 205920002531 Subunit I/VIc interface [polypeptide binding]; other site 205920002532 Electron transfer pathway; other site 205920002533 Subunit I/VIIIb interface [polypeptide binding]; other site 205920002534 Subunit I/VIIb interface [polypeptide binding]; other site 205920002535 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 205920002536 UbiA prenyltransferase family; Region: UbiA; pfam01040 205920002537 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 205920002538 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 205920002539 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 205920002540 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 205920002541 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 205920002542 Preprotein translocase subunit; Region: YajC; pfam02699 205920002543 DNA polymerase III subunit beta; Validated; Region: PRK05643 205920002544 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 205920002545 putative DNA binding surface [nucleotide binding]; other site 205920002546 dimer interface [polypeptide binding]; other site 205920002547 beta-clamp/clamp loader binding surface; other site 205920002548 beta-clamp/translesion DNA polymerase binding surface; other site 205920002549 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 205920002550 putative DNA binding surface [nucleotide binding]; other site 205920002551 dimer interface [polypeptide binding]; other site 205920002552 beta-clamp/clamp loader binding surface; other site 205920002553 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 205920002554 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 205920002555 catalytic site [active] 205920002556 putative active site [active] 205920002557 putative substrate binding site [chemical binding]; other site 205920002558 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 205920002559 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205920002560 active site 205920002561 phosphorylation site [posttranslational modification] 205920002562 intermolecular recognition site; other site 205920002563 dimerization interface [polypeptide binding]; other site 205920002564 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205920002565 DNA binding site [nucleotide binding] 205920002566 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 205920002567 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205920002568 non-specific DNA binding site [nucleotide binding]; other site 205920002569 salt bridge; other site 205920002570 sequence-specific DNA binding site [nucleotide binding]; other site 205920002571 Predicted transcriptional regulator [Transcription]; Region: COG2932 205920002572 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 205920002573 Catalytic site [active] 205920002574 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 205920002575 dimer interface [polypeptide binding]; other site 205920002576 substrate binding site [chemical binding]; other site 205920002577 metal binding sites [ion binding]; metal-binding site 205920002578 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 205920002579 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 205920002580 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 205920002581 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 205920002582 23S rRNA interface [nucleotide binding]; other site 205920002583 L3 interface [polypeptide binding]; other site 205920002584 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 205920002585 Protein of unknown function (DUF2497); Region: DUF2497; pfam10691 205920002586 Domain of unknown function DUF59; Region: DUF59; pfam01883 205920002587 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 205920002588 Walker A motif; other site 205920002589 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 205920002590 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 205920002591 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 205920002592 active site 205920002593 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 205920002594 aconitate hydratase; Validated; Region: PRK09277 205920002595 aconitate hydratase; Validated; Region: PRK09277 205920002596 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 205920002597 substrate binding site [chemical binding]; other site 205920002598 ligand binding site [chemical binding]; other site 205920002599 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 205920002600 substrate binding site [chemical binding]; other site 205920002601 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 205920002602 phosphoribosylaminoimidazole carboxylase, PurK protein; Region: purK; TIGR01161 205920002603 ATP-grasp domain; Region: ATP-grasp; pfam02222 205920002604 identified by similarity to GB:AAK31315.1; similar to conserved hypothetical protein, degenerate 205920002605 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 205920002606 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 205920002607 TrbC/VIRB2 family; Region: TrbC; pfam04956 205920002608 TrbC/VIRB2 family; Region: TrbC; pfam04956 205920002609 TrbC/VIRB2 family; Region: TrbC; pfam04956 205920002610 TrbC/VIRB2 family; Region: TrbC; pfam04956 205920002611 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 205920002612 HflK protein; Region: hflK; TIGR01933 205920002613 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 205920002614 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 205920002615 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 205920002616 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 205920002617 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 205920002618 protein binding site [polypeptide binding]; other site 205920002619 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 205920002620 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 205920002621 ribonuclease III; Reviewed; Region: rnc; PRK00102 205920002622 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 205920002623 dimerization interface [polypeptide binding]; other site 205920002624 active site 205920002625 metal binding site [ion binding]; metal-binding site 205920002626 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 205920002627 dsRNA binding site [nucleotide binding]; other site 205920002628 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 205920002629 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 205920002630 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 205920002631 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 205920002632 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 205920002633 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 205920002634 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 205920002635 lipoprotein signal peptidase; Provisional; Region: PRK14787 205920002636 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 205920002637 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 205920002638 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 205920002639 active site 205920002640 Riboflavin kinase; Region: Flavokinase; smart00904 205920002641 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 205920002642 GSH binding site [chemical binding]; other site 205920002643 catalytic residues [active] 205920002644 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 205920002645 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205920002646 S-adenosylmethionine binding site [chemical binding]; other site 205920002647 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 205920002648 active site 205920002649 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 205920002650 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 205920002651 E3 interaction surface; other site 205920002652 lipoyl attachment site [posttranslational modification]; other site 205920002653 e3 binding domain; Region: E3_binding; pfam02817 205920002654 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 205920002655 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 205920002656 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 205920002657 trimer interface [polypeptide binding]; other site 205920002658 putative metal binding site [ion binding]; other site 205920002659 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 205920002660 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 205920002661 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 205920002662 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 205920002663 DsbD alpha interface [polypeptide binding]; other site 205920002664 catalytic residues [active] 205920002665 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 205920002666 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 205920002667 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 205920002668 active site 205920002669 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 205920002670 protein binding site [polypeptide binding]; other site 205920002671 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 205920002672 putative substrate binding region [chemical binding]; other site 205920002673 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 205920002674 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 205920002675 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 205920002676 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 205920002677 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 205920002678 Surface antigen; Region: Bac_surface_Ag; pfam01103 205920002679 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 205920002680 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 205920002681 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 205920002682 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 205920002683 purine monophosphate binding site [chemical binding]; other site 205920002684 dimer interface [polypeptide binding]; other site 205920002685 putative catalytic residues [active] 205920002686 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 205920002687 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 205920002688 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 205920002689 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 205920002690 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 205920002691 Putative proton exit pathway; other site 205920002692 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 205920002693 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 205920002694 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 205920002695 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 205920002696 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 205920002697 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 205920002698 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 205920002699 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 205920002700 active site 205920002701 NAD binding site [chemical binding]; other site 205920002702 metal binding site [ion binding]; metal-binding site 205920002703 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 205920002704 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 205920002705 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 205920002706 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 205920002707 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 205920002708 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 205920002709 cell division protein FtsA; Region: ftsA; TIGR01174 205920002710 Cell division protein FtsA; Region: FtsA; smart00842 205920002711 Cell division protein FtsA; Region: FtsA; pfam14450 205920002712 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 205920002713 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 205920002714 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 205920002715 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 205920002716 Ligand Binding Site [chemical binding]; other site 205920002717 FtsH Extracellular; Region: FtsH_ext; pfam06480 205920002718 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 205920002719 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205920002720 Walker A motif; other site 205920002721 ATP binding site [chemical binding]; other site 205920002722 Walker B motif; other site 205920002723 arginine finger; other site 205920002724 Peptidase family M41; Region: Peptidase_M41; pfam01434 205920002725 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 205920002726 Zinc-finger domain; Region: zf-CHCC; cl01821 205920002727 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 205920002728 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 205920002729 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 205920002730 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 205920002731 ATP binding site [chemical binding]; other site 205920002732 substrate interface [chemical binding]; other site 205920002733 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 205920002734 active site 205920002735 recombinase A; Provisional; Region: recA; PRK09354 205920002736 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 205920002737 hexamer interface [polypeptide binding]; other site 205920002738 Walker A motif; other site 205920002739 ATP binding site [chemical binding]; other site 205920002740 Walker B motif; other site 205920002741 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 205920002742 AAA domain; Region: AAA_26; pfam13500 205920002743 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 205920002744 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 205920002745 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 205920002746 isocitrate dehydrogenase; Validated; Region: PRK09222 205920002747 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 205920002748 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 205920002749 DHH family; Region: DHH; pfam01368 205920002750 DHHA1 domain; Region: DHHA1; pfam02272 205920002751 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 205920002752 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 205920002753 active site 205920002754 NTP binding site [chemical binding]; other site 205920002755 metal binding triad [ion binding]; metal-binding site 205920002756 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 205920002757 NgoBV restriction endonuclease; Region: RE_NgoBV; pfam09564 205920002758 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 205920002759 active site 205920002760 multimer interface [polypeptide binding]; other site 205920002761 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 205920002762 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205920002763 non-specific DNA binding site [nucleotide binding]; other site 205920002764 salt bridge; other site 205920002765 sequence-specific DNA binding site [nucleotide binding]; other site 205920002766 Surface antigen; Region: Surface_Ag_2; pfam01617 205920002767 Surface antigen; Region: Surface_Ag_2; pfam01617 205920002768 Surface antigen; Region: Surface_Ag_2; pfam01617 205920002769 Surface antigen; Region: Surface_Ag_2; pfam01617 205920002770 Surface antigen; Region: Surface_Ag_2; pfam01617 205920002771 Surface antigen; Region: Surface_Ag_2; pfam01617 205920002772 Surface antigen; Region: Surface_Ag_2; pfam01617 205920002773 Surface antigen; Region: Surface_Ag_2; pfam01617 205920002774 Surface antigen; Region: Surface_Ag_2; pfam01617 205920002775 Surface antigen; Region: Surface_Ag_2; pfam01617 205920002776 Surface antigen; Region: Surface_Ag_2; pfam01617 205920002777 Surface antigen; Region: Surface_Ag_2; pfam01617 205920002778 Surface antigen; Region: Surface_Ag_2; pfam01617 205920002779 Surface antigen; Region: Surface_Ag_2; pfam01617 205920002780 Surface antigen; Region: Surface_Ag_2; pfam01617 205920002781 Surface antigen; Region: Surface_Ag_2; pfam01617 205920002782 Surface antigen; Region: Surface_Ag_2; pfam01617 205920002783 Surface antigen; Region: Surface_Ag_2; pfam01617 205920002784 Surface antigen; Region: Surface_Ag_2; pfam01617 205920002785 Surface antigen; Region: Surface_Ag_2; pfam01617 205920002786 Surface antigen; Region: Surface_Ag_2; pfam01617 205920002787 Surface antigen; Region: Surface_Ag_2; pfam01617 205920002788 kinesin-12 family protein; Provisional; Region: PLN03188 205920002789 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 205920002790 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 205920002791 SEC-C motif; Region: SEC-C; pfam02810 205920002792 cell division protein FtsZ; Validated; Region: PRK09330 205920002793 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 205920002794 nucleotide binding site [chemical binding]; other site 205920002795 SulA interaction site; other site 205920002796 EVE domain; Region: EVE; pfam01878 205920002797 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 205920002798 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 205920002799 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 205920002800 P-loop; other site 205920002801 Magnesium ion binding site [ion binding]; other site 205920002802 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 205920002803 Magnesium ion binding site [ion binding]; other site