-- dump date 20140619_064505 -- class Genbank::misc_feature -- table misc_feature_note -- id note 573370000001 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 573370000002 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 573370000003 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573370000004 P-loop; other site 573370000005 Magnesium ion binding site [ion binding]; other site 573370000006 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573370000007 HB1, ASXL, restriction endonuclease HTH domain; Region: HARE-HTH; pfam05066 573370000008 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 573370000009 GIY-YIG motif/motif A; other site 573370000010 active site 573370000011 catalytic site [active] 573370000012 metal binding site [ion binding]; metal-binding site 573370000013 Replicative DNA helicase [DNA replication, recombination, and repair]; Region: DnaB; COG0305 573370000014 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 573370000015 Walker A motif; other site 573370000016 ATP binding site [chemical binding]; other site 573370000017 Walker B motif; other site 573370000018 Replicative DNA helicase [DNA replication, recombination, and repair]; Region: DnaB; COG0305 573370000019 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 573370000020 Walker A motif; other site 573370000021 ATP binding site [chemical binding]; other site 573370000022 Walker B motif; other site 573370000023 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 573370000024 catalytic residues [active] 573370000025 catalytic nucleophile [active] 573370000026 Presynaptic Site I dimer interface [polypeptide binding]; other site 573370000027 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 573370000028 Synaptic Flat tetramer interface [polypeptide binding]; other site 573370000029 Synaptic Site I dimer interface [polypeptide binding]; other site 573370000030 DNA binding site [nucleotide binding] 573370000031 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 573370000032 Predicted transcriptional regulator [Transcription]; Region: COG3905 573370000033 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 573370000034 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370000035 Walker A motif; other site 573370000036 ATP binding site [chemical binding]; other site 573370000037 Walker B motif; other site 573370000038 arginine finger; other site 573370000039 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 573370000040 DnaA box-binding interface [nucleotide binding]; other site 573370000041 DNA polymerase III subunit beta; Provisional; Region: PRK14947 573370000042 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 573370000043 putative DNA binding surface [nucleotide binding]; other site 573370000044 dimer interface [polypeptide binding]; other site 573370000045 beta-clamp/clamp loader binding surface; other site 573370000046 beta-clamp/translesion DNA polymerase binding surface; other site 573370000047 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 573370000048 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370000049 ATP binding site [chemical binding]; other site 573370000050 Mg2+ binding site [ion binding]; other site 573370000051 G-X-G motif; other site 573370000052 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 573370000053 anchoring element; other site 573370000054 dimer interface [polypeptide binding]; other site 573370000055 ATP binding site [chemical binding]; other site 573370000056 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 573370000057 active site 573370000058 metal binding site [ion binding]; metal-binding site 573370000059 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 573370000060 DNA gyrase subunit A; Validated; Region: PRK05560 573370000061 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 573370000062 CAP-like domain; other site 573370000063 active site 573370000064 primary dimer interface [polypeptide binding]; other site 573370000065 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 573370000066 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 573370000067 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 573370000068 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 573370000069 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 573370000070 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 573370000071 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 573370000072 PilZ domain; Region: PilZ; pfam07238 573370000073 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 573370000074 Flavoprotein; Region: Flavoprotein; cl19190 573370000075 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 573370000076 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 573370000077 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 573370000078 dimer interface [polypeptide binding]; other site 573370000079 active site residues [active] 573370000080 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 573370000081 prohibitin homologues; Region: PHB; smart00244 573370000082 Uncharacterized prokaryotic subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_eoslipins_u1; cd08826 573370000083 trimer interface [polypeptide binding]; other site 573370000084 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 573370000085 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 573370000086 putative NAD(P) binding site [chemical binding]; other site 573370000087 active site 573370000088 putative substrate binding site [chemical binding]; other site 573370000089 XXXCH domain; Region: XXXCH_domain; TIGR04358 573370000090 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 573370000091 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 573370000092 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573370000093 P-loop; other site 573370000094 Magnesium ion binding site [ion binding]; other site 573370000095 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 573370000096 ParB-like nuclease domain; Region: ParB; smart00470 573370000097 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 573370000098 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 573370000099 putative ribose interaction site [chemical binding]; other site 573370000100 putative ADP binding site [chemical binding]; other site 573370000101 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 573370000102 anti sigma factor interaction site; other site 573370000103 regulatory phosphorylation site [posttranslational modification]; other site 573370000104 Permease; Region: Permease; pfam02405 573370000105 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 573370000106 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573370000107 Walker A/P-loop; other site 573370000108 ATP binding site [chemical binding]; other site 573370000109 Q-loop/lid; other site 573370000110 ABC transporter signature motif; other site 573370000111 Walker B; other site 573370000112 D-loop; other site 573370000113 H-loop/switch region; other site 573370000114 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 573370000115 mce related protein; Region: MCE; pfam02470 573370000116 Protein of unknown function (DUF330); Region: DUF330; cl01135 573370000117 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573370000118 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573370000119 WHG domain; Region: WHG; pfam13305 573370000120 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 573370000121 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 573370000122 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 573370000123 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 573370000124 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370000125 S-adenosylmethionine binding site [chemical binding]; other site 573370000126 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 573370000127 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 573370000128 dimer interface [polypeptide binding]; other site 573370000129 motif 1; other site 573370000130 active site 573370000131 motif 2; other site 573370000132 motif 3; other site 573370000133 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 573370000134 anticodon binding site; other site 573370000135 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 573370000136 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 573370000137 dimer interface [polypeptide binding]; other site 573370000138 anticodon binding site; other site 573370000139 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 573370000140 homodimer interface [polypeptide binding]; other site 573370000141 motif 1; other site 573370000142 active site 573370000143 motif 2; other site 573370000144 GAD domain; Region: GAD; pfam02938 573370000145 motif 3; other site 573370000146 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 573370000147 active site 573370000148 catalytic residues [active] 573370000149 metal binding site [ion binding]; metal-binding site 573370000150 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 573370000151 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 573370000152 putative active site [active] 573370000153 substrate binding site [chemical binding]; other site 573370000154 putative cosubstrate binding site; other site 573370000155 catalytic site [active] 573370000156 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 573370000157 substrate binding site [chemical binding]; other site 573370000158 Protein of unknown function DUF116; Region: DUF116; pfam01976 573370000159 NusB family; Region: NusB; pfam01029 573370000160 putative RNA binding site [nucleotide binding]; other site 573370000161 16S rRNA methyltransferase B; Provisional; Region: PRK14901 573370000162 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370000163 S-adenosylmethionine binding site [chemical binding]; other site 573370000164 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 573370000165 active site 573370000166 FMN binding site [chemical binding]; other site 573370000167 substrate binding site [chemical binding]; other site 573370000168 homotetramer interface [polypeptide binding]; other site 573370000169 catalytic residue [active] 573370000170 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370000171 dimerization interface [polypeptide binding]; other site 573370000172 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370000173 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573370000174 dimer interface [polypeptide binding]; other site 573370000175 putative CheW interface [polypeptide binding]; other site 573370000176 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 573370000177 AMIN domain; Region: AMIN; pfam11741 573370000178 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 573370000179 active site 573370000180 oxyanion hole [active] 573370000181 Protein of unknown function (DUF1134); Region: DUF1134; cl02235 573370000182 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 573370000183 Aspartase; Region: Aspartase; cd01357 573370000184 active sites [active] 573370000185 tetramer interface [polypeptide binding]; other site 573370000186 PAS fold; Region: PAS; pfam00989 573370000187 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370000188 putative active site [active] 573370000189 heme pocket [chemical binding]; other site 573370000190 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 573370000191 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370000192 Walker A motif; other site 573370000193 ATP binding site [chemical binding]; other site 573370000194 Walker B motif; other site 573370000195 arginine finger; other site 573370000196 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 573370000197 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 573370000198 active site 573370000199 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 573370000200 homodimer interface [polypeptide binding]; other site 573370000201 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 573370000202 active site pocket [active] 573370000203 GAF domain; Region: GAF_3; pfam13492 573370000204 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370000205 metal binding site [ion binding]; metal-binding site 573370000206 active site 573370000207 I-site; other site 573370000208 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 573370000209 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 573370000210 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 573370000211 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 573370000212 Transposase; Region: DEDD_Tnp_IS110; pfam01548 573370000213 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 573370000214 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370000215 active site 573370000216 phosphorylation site [posttranslational modification] 573370000217 intermolecular recognition site; other site 573370000218 dimerization interface [polypeptide binding]; other site 573370000219 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370000220 active site 573370000221 phosphorylation site [posttranslational modification] 573370000222 intermolecular recognition site; other site 573370000223 dimerization interface [polypeptide binding]; other site 573370000224 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 573370000225 active site 573370000226 Amidinotransferase; Region: Amidinotransf; cl19186 573370000227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573370000228 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573370000229 putative substrate translocation pore; other site 573370000230 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 573370000231 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 573370000232 active site 573370000233 dimer interface [polypeptide binding]; other site 573370000234 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 573370000235 Ligand Binding Site [chemical binding]; other site 573370000236 Molecular Tunnel; other site 573370000237 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 573370000238 putative ADP-binding pocket [chemical binding]; other site 573370000239 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573370000240 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 573370000241 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370000242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370000243 active site 573370000244 phosphorylation site [posttranslational modification] 573370000245 intermolecular recognition site; other site 573370000246 dimerization interface [polypeptide binding]; other site 573370000247 PilZ domain; Region: PilZ; pfam07238 573370000248 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 573370000249 active site clefts [active] 573370000250 zinc binding site [ion binding]; other site 573370000251 dimer interface [polypeptide binding]; other site 573370000252 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573370000253 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 573370000254 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 573370000255 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 573370000256 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 573370000257 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 573370000258 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 573370000259 putative active site [active] 573370000260 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 573370000261 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 573370000262 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573370000263 FeS/SAM binding site; other site 573370000264 Transposase domain (DUF772); Region: DUF772; pfam05598 573370000265 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573370000266 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 573370000267 HD domain; Region: HD; pfam01966 573370000268 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 573370000269 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 573370000270 dihydroorotase; Validated; Region: pyrC; PRK09357 573370000271 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 573370000272 active site 573370000273 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 573370000274 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 573370000275 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 573370000276 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 573370000277 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 573370000278 active site 573370000279 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 573370000280 active site 573370000281 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 573370000282 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 573370000283 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 573370000284 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573370000285 Walker A/P-loop; other site 573370000286 ATP binding site [chemical binding]; other site 573370000287 Q-loop/lid; other site 573370000288 ABC transporter signature motif; other site 573370000289 Walker B; other site 573370000290 D-loop; other site 573370000291 H-loop/switch region; other site 573370000292 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 573370000293 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 573370000294 Walker A/P-loop; other site 573370000295 ATP binding site [chemical binding]; other site 573370000296 Q-loop/lid; other site 573370000297 ABC transporter signature motif; other site 573370000298 H-loop/switch region; other site 573370000299 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 573370000300 ABC transporter signature motif; other site 573370000301 Walker B; other site 573370000302 D-loop; other site 573370000303 H-loop/switch region; other site 573370000304 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 573370000305 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 573370000306 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573370000307 dimer interface [polypeptide binding]; other site 573370000308 conserved gate region; other site 573370000309 putative PBP binding loops; other site 573370000310 ABC-ATPase subunit interface; other site 573370000311 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 573370000312 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573370000313 dimer interface [polypeptide binding]; other site 573370000314 conserved gate region; other site 573370000315 putative PBP binding loops; other site 573370000316 ABC-ATPase subunit interface; other site 573370000317 AIPR protein; Region: AIPR; pfam10592 573370000318 Xylose isomerase [Carbohydrate transport and metabolism]; Region: XylA; cl09945 573370000319 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; cl19880 573370000320 Replicase family; Region: Replicase; pfam03090 573370000321 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 573370000322 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573370000323 active site 573370000324 DNA binding site [nucleotide binding] 573370000325 Int/Topo IB signature motif; other site 573370000326 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 573370000327 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573370000328 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 573370000329 active site 573370000330 catalytic residues [active] 573370000331 DNA binding site [nucleotide binding] 573370000332 Int/Topo IB signature motif; other site 573370000333 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 573370000334 Protein of unknown function, DUF488; Region: DUF488; cl01246 573370000335 hypothetical protein; Provisional; Region: PRK14709 573370000336 D5 N terminal like; Region: D5_N; smart00885 573370000337 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 573370000338 Radical SAM superfamily; Region: Radical_SAM; pfam04055 573370000339 tegument protein VP11/12; Provisional; Region: PHA03195 573370000340 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; cl19880 573370000341 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 573370000342 Domain of unknown function (DUF927); Region: DUF927; cl12098 573370000343 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573370000344 active site 573370000345 DNA binding site [nucleotide binding] 573370000346 Int/Topo IB signature motif; other site 573370000347 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 573370000348 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 573370000349 active site 573370000350 catalytic residues [active] 573370000351 DNA binding site [nucleotide binding] 573370000352 Int/Topo IB signature motif; other site 573370000353 Predicted transcriptional regulator [Transcription]; Region: COG2378 573370000354 WYL domain; Region: WYL; pfam13280 573370000355 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 573370000356 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 573370000357 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 573370000358 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 573370000359 Transposase; Region: DEDD_Tnp_IS110; pfam01548 573370000360 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 573370000361 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 573370000362 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 573370000363 Transposase IS200 like; Region: Y1_Tnp; pfam01797 573370000364 Transposase domain (DUF772); Region: DUF772; pfam05598 573370000365 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573370000366 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 573370000367 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 573370000368 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573370000369 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573370000370 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573370000371 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 573370000372 dimer interface [polypeptide binding]; other site 573370000373 active site 573370000374 metal binding site [ion binding]; metal-binding site 573370000375 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 573370000376 Putative lysophospholipase; Region: Hydrolase_4; cl19140 573370000377 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 573370000378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573370000379 putative substrate translocation pore; other site 573370000380 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 573370000381 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 573370000382 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 573370000383 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370000384 dimerization interface [polypeptide binding]; other site 573370000385 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370000386 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573370000387 dimer interface [polypeptide binding]; other site 573370000388 putative CheW interface [polypeptide binding]; other site 573370000389 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; cl19880 573370000390 Transposase domain (DUF772); Region: DUF772; pfam05598 573370000391 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573370000392 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 573370000393 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 573370000394 dimer interface [polypeptide binding]; other site 573370000395 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 573370000396 dimer interface [polypeptide binding]; other site 573370000397 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370000398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370000399 active site 573370000400 phosphorylation site [posttranslational modification] 573370000401 intermolecular recognition site; other site 573370000402 dimerization interface [polypeptide binding]; other site 573370000403 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573370000404 DNA binding site [nucleotide binding] 573370000405 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370000406 dimerization interface [polypeptide binding]; other site 573370000407 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370000408 dimer interface [polypeptide binding]; other site 573370000409 phosphorylation site [posttranslational modification] 573370000410 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370000411 ATP binding site [chemical binding]; other site 573370000412 Mg2+ binding site [ion binding]; other site 573370000413 G-X-G motif; other site 573370000414 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 573370000415 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 573370000416 acyl-activating enzyme (AAE) consensus motif; other site 573370000417 AMP binding site [chemical binding]; other site 573370000418 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573370000419 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 573370000420 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 573370000421 putative trimer interface [polypeptide binding]; other site 573370000422 putative CoA binding site [chemical binding]; other site 573370000423 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 573370000424 putative trimer interface [polypeptide binding]; other site 573370000425 putative CoA binding site [chemical binding]; other site 573370000426 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 573370000427 putative trimer interface [polypeptide binding]; other site 573370000428 putative CoA binding site [chemical binding]; other site 573370000429 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 573370000430 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 573370000431 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573370000432 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573370000433 non-specific DNA binding site [nucleotide binding]; other site 573370000434 salt bridge; other site 573370000435 sequence-specific DNA binding site [nucleotide binding]; other site 573370000436 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370000437 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370000438 putative active site [active] 573370000439 heme pocket [chemical binding]; other site 573370000440 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370000441 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370000442 putative active site [active] 573370000443 heme pocket [chemical binding]; other site 573370000444 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370000445 putative active site [active] 573370000446 heme pocket [chemical binding]; other site 573370000447 Sensory domain found in PocR; Region: PocR; cl19879 573370000448 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370000449 dimer interface [polypeptide binding]; other site 573370000450 phosphorylation site [posttranslational modification] 573370000451 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370000452 ATP binding site [chemical binding]; other site 573370000453 Mg2+ binding site [ion binding]; other site 573370000454 G-X-G motif; other site 573370000455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370000456 active site 573370000457 phosphorylation site [posttranslational modification] 573370000458 intermolecular recognition site; other site 573370000459 dimerization interface [polypeptide binding]; other site 573370000460 Transposase domain (DUF772); Region: DUF772; pfam05598 573370000461 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573370000462 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 573370000463 PAS domain S-box; Region: sensory_box; TIGR00229 573370000464 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370000465 putative active site [active] 573370000466 heme pocket [chemical binding]; other site 573370000467 PAS domain S-box; Region: sensory_box; TIGR00229 573370000468 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370000469 putative active site [active] 573370000470 heme pocket [chemical binding]; other site 573370000471 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 573370000472 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370000473 dimer interface [polypeptide binding]; other site 573370000474 phosphorylation site [posttranslational modification] 573370000475 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370000476 ATP binding site [chemical binding]; other site 573370000477 Mg2+ binding site [ion binding]; other site 573370000478 G-X-G motif; other site 573370000479 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370000480 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370000481 active site 573370000482 phosphorylation site [posttranslational modification] 573370000483 intermolecular recognition site; other site 573370000484 dimerization interface [polypeptide binding]; other site 573370000485 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 573370000486 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 573370000487 Cation transport protein; Region: TrkH; cl17365 573370000488 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 573370000489 Cation transport protein; Region: TrkH; cl17365 573370000490 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 573370000491 TrkA-N domain; Region: TrkA_N; pfam02254 573370000492 TrkA-C domain; Region: TrkA_C; pfam02080 573370000493 GTPase CgtA; Reviewed; Region: obgE; PRK12299 573370000494 GTP1/OBG; Region: GTP1_OBG; pfam01018 573370000495 Obg GTPase; Region: Obg; cd01898 573370000496 G1 box; other site 573370000497 GTP/Mg2+ binding site [chemical binding]; other site 573370000498 Switch I region; other site 573370000499 G2 box; other site 573370000500 G3 box; other site 573370000501 Switch II region; other site 573370000502 G4 box; other site 573370000503 G5 box; other site 573370000504 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 573370000505 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 573370000506 putative RNA binding site [nucleotide binding]; other site 573370000507 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370000508 S-adenosylmethionine binding site [chemical binding]; other site 573370000509 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 573370000510 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 573370000511 ligand binding site [chemical binding]; other site 573370000512 PAS domain S-box; Region: sensory_box; TIGR00229 573370000513 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370000514 putative active site [active] 573370000515 heme pocket [chemical binding]; other site 573370000516 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 573370000517 Histidine kinase; Region: HisKA_2; pfam07568 573370000518 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370000519 ATP binding site [chemical binding]; other site 573370000520 Mg2+ binding site [ion binding]; other site 573370000521 G-X-G motif; other site 573370000522 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 573370000523 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 573370000524 G1 box; other site 573370000525 GTP/Mg2+ binding site [chemical binding]; other site 573370000526 Switch I region; other site 573370000527 G2 box; other site 573370000528 Switch II region; other site 573370000529 G3 box; other site 573370000530 G4 box; other site 573370000531 G5 box; other site 573370000532 biotin synthase; Provisional; Region: PRK07094 573370000533 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573370000534 FeS/SAM binding site; other site 573370000535 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 573370000536 PRC-barrel domain; Region: PRC; pfam05239 573370000537 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 573370000538 Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155 573370000539 putative active site [active] 573370000540 catalytic site [active] 573370000541 Putative catalytic domain, repeat 2, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_2; cd09161 573370000542 putative active site [active] 573370000543 catalytic site [active] 573370000544 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573370000545 non-specific DNA binding site [nucleotide binding]; other site 573370000546 salt bridge; other site 573370000547 sequence-specific DNA binding site [nucleotide binding]; other site 573370000548 Predicted transcriptional regulator [Transcription]; Region: COG2932 573370000549 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 573370000550 Catalytic site [active] 573370000551 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 573370000552 Cache domain; Region: Cache_1; pfam02743 573370000553 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370000554 dimerization interface [polypeptide binding]; other site 573370000555 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370000556 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573370000557 dimer interface [polypeptide binding]; other site 573370000558 putative CheW interface [polypeptide binding]; other site 573370000559 Low molecular weight phosphatase family; Region: LMWPc; cd00115 573370000560 active site 573370000561 Low molecular weight phosphatase family; Region: LMWPc; cd00115 573370000562 active site 573370000563 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 573370000564 dimer interface [polypeptide binding]; other site 573370000565 active site 573370000566 metal binding site [ion binding]; metal-binding site 573370000567 Heterodisulfide reductase, subunit C [Energy production and conversion]; Region: HdrC; COG1150 573370000568 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 573370000569 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 573370000570 Cysteine-rich domain; Region: CCG; pfam02754 573370000571 Cysteine-rich domain; Region: CCG; pfam02754 573370000572 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 573370000573 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 573370000574 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 573370000575 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 573370000576 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 573370000577 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 573370000578 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 573370000579 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 573370000580 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 573370000581 cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345 573370000582 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 573370000583 FAD binding pocket [chemical binding]; other site 573370000584 FAD binding motif [chemical binding]; other site 573370000585 phosphate binding motif [ion binding]; other site 573370000586 beta-alpha-beta structure motif; other site 573370000587 NAD binding pocket [chemical binding]; other site 573370000588 Iron coordination center [ion binding]; other site 573370000589 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 573370000590 diiron binding motif [ion binding]; other site 573370000591 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370000592 PAS domain; Region: PAS_8; pfam13188 573370000593 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 573370000594 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370000595 dimer interface [polypeptide binding]; other site 573370000596 phosphorylation site [posttranslational modification] 573370000597 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370000598 ATP binding site [chemical binding]; other site 573370000599 Mg2+ binding site [ion binding]; other site 573370000600 G-X-G motif; other site 573370000601 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 573370000602 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370000603 active site 573370000604 phosphorylation site [posttranslational modification] 573370000605 intermolecular recognition site; other site 573370000606 dimerization interface [polypeptide binding]; other site 573370000607 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370000608 Walker A motif; other site 573370000609 ATP binding site [chemical binding]; other site 573370000610 Walker B motif; other site 573370000611 arginine finger; other site 573370000612 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 573370000613 HdeA/HdeB family; Region: HdeA; cl05752 573370000614 Ion channel; Region: Ion_trans_2; pfam07885 573370000615 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 573370000616 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 573370000617 ligand binding site [chemical binding]; other site 573370000618 flexible hinge region; other site 573370000619 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 573370000620 conserved cys residue [active] 573370000621 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 573370000622 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 573370000623 active site 573370000624 HIGH motif; other site 573370000625 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 573370000626 KMSKS motif; other site 573370000627 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 573370000628 tRNA binding surface [nucleotide binding]; other site 573370000629 anticodon binding site; other site 573370000630 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 573370000631 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573370000632 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370000633 active site 573370000634 phosphorylation site [posttranslational modification] 573370000635 intermolecular recognition site; other site 573370000636 dimerization interface [polypeptide binding]; other site 573370000637 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370000638 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370000639 putative active site [active] 573370000640 heme pocket [chemical binding]; other site 573370000641 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370000642 putative active site [active] 573370000643 heme pocket [chemical binding]; other site 573370000644 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370000645 metal binding site [ion binding]; metal-binding site 573370000646 active site 573370000647 I-site; other site 573370000648 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 573370000649 squalene monooxygenase; Region: PLN02985 573370000650 FOG: CBS domain [General function prediction only]; Region: COG0517 573370000651 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 573370000652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370000653 active site 573370000654 phosphorylation site [posttranslational modification] 573370000655 intermolecular recognition site; other site 573370000656 dimerization interface [polypeptide binding]; other site 573370000657 PAS domain S-box; Region: sensory_box; TIGR00229 573370000658 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370000659 metal binding site [ion binding]; metal-binding site 573370000660 active site 573370000661 I-site; other site 573370000662 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 573370000663 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 573370000664 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 573370000665 putative active site [active] 573370000666 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 573370000667 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 573370000668 putative active site [active] 573370000669 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573370000670 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573370000671 Walker A/P-loop; other site 573370000672 ATP binding site [chemical binding]; other site 573370000673 Q-loop/lid; other site 573370000674 ABC transporter signature motif; other site 573370000675 Walker B; other site 573370000676 D-loop; other site 573370000677 H-loop/switch region; other site 573370000678 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 573370000679 Glucose inhibited division protein A; Region: GIDA; pfam01134 573370000680 Predicted dehydrogenase [General function prediction only]; Region: COG0579 573370000681 hydroxyglutarate oxidase; Provisional; Region: PRK11728; cl19156 573370000682 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573370000683 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 573370000684 active site 573370000685 motif I; other site 573370000686 motif II; other site 573370000687 UDP-N-acetylmuramate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: MurB; COG0812 573370000688 FAD binding domain; Region: FAD_binding_4; cl19922 573370000689 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 573370000690 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 573370000691 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 573370000692 ligand binding site [chemical binding]; other site 573370000693 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 573370000694 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 573370000695 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 573370000696 HlyD family secretion protein; Region: HlyD_3; pfam13437 573370000697 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 573370000698 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 573370000699 inhibitor-cofactor binding pocket; inhibition site 573370000700 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573370000701 catalytic residue [active] 573370000702 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 573370000703 dimer interface [polypeptide binding]; other site 573370000704 ligand binding site [chemical binding]; other site 573370000705 3D domain; Region: 3D; cl01439 573370000706 Cache domain; Region: Cache_1; pfam02743 573370000707 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 573370000708 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370000709 dimerization interface [polypeptide binding]; other site 573370000710 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 573370000711 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 573370000712 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 573370000713 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 573370000714 Sporulation related domain; Region: SPOR; pfam05036 573370000715 Alpha subunit of integration host factor (IHFA); Region: IHF_A; cd13835 573370000716 DNA binding site [nucleotide binding] 573370000717 dimer interface [polypeptide binding]; other site 573370000718 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 573370000719 HIT family signature motif; other site 573370000720 catalytic residue [active] 573370000721 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 573370000722 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 573370000723 Amidohydrolase; Region: Amidohydro_4; pfam13147 573370000724 active site 573370000725 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 573370000726 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 573370000727 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 573370000728 Rrf2 family protein; Region: rrf2_super; TIGR00738 573370000729 Predicted transcriptional regulator [Transcription]; Region: COG1959 573370000730 MOSC domain; Region: MOSC; pfam03473 573370000731 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 573370000732 catalytic triad [active] 573370000733 conserved cis-peptide bond; other site 573370000734 ThiS family; Region: ThiS; pfam02597 573370000735 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; smart00790 573370000736 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 573370000737 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 573370000738 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 573370000739 active site 573370000740 NAD binding site [chemical binding]; other site 573370000741 metal binding site [ion binding]; metal-binding site 573370000742 PAS domain; Region: PAS; smart00091 573370000743 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 573370000744 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370000745 dimer interface [polypeptide binding]; other site 573370000746 phosphorylation site [posttranslational modification] 573370000747 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370000748 ATP binding site [chemical binding]; other site 573370000749 Mg2+ binding site [ion binding]; other site 573370000750 G-X-G motif; other site 573370000751 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 573370000752 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370000753 active site 573370000754 phosphorylation site [posttranslational modification] 573370000755 intermolecular recognition site; other site 573370000756 dimerization interface [polypeptide binding]; other site 573370000757 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370000758 Walker A motif; other site 573370000759 ATP binding site [chemical binding]; other site 573370000760 Walker B motif; other site 573370000761 arginine finger; other site 573370000762 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 573370000763 PAS domain S-box; Region: sensory_box; TIGR00229 573370000764 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370000765 metal binding site [ion binding]; metal-binding site 573370000766 active site 573370000767 I-site; other site 573370000768 Hemerythrin; Region: Hemerythrin; cd12107 573370000769 Fe binding site [ion binding]; other site 573370000770 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 573370000771 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370000772 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 573370000773 dimer interface [polypeptide binding]; other site 573370000774 putative CheW interface [polypeptide binding]; other site 573370000775 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 573370000776 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 573370000777 active site 573370000778 Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257 573370000779 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 573370000780 putative dimer interface [polypeptide binding]; other site 573370000781 [2Fe-2S] cluster binding site [ion binding]; other site 573370000782 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 573370000783 dimer interface [polypeptide binding]; other site 573370000784 [2Fe-2S] cluster binding site [ion binding]; other site 573370000785 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 573370000786 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 573370000787 SLBB domain; Region: SLBB; pfam10531 573370000788 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 573370000789 4Fe-4S dicluster domain; Region: Fer4_21; pfam14697 573370000790 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 573370000791 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 573370000792 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 573370000793 catalytic loop [active] 573370000794 iron binding site [ion binding]; other site 573370000795 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 573370000796 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 573370000797 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 573370000798 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 573370000799 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 573370000800 aspartate ammonia-lyase; Provisional; Region: PRK13353 573370000801 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 573370000802 tetramer interface [polypeptide binding]; other site 573370000803 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 573370000804 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 573370000805 Protein of unknown function, DUF484; Region: DUF484; cl17449 573370000806 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573370000807 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370000808 dimer interface [polypeptide binding]; other site 573370000809 phosphorylation site [posttranslational modification] 573370000810 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370000811 ATP binding site [chemical binding]; other site 573370000812 Mg2+ binding site [ion binding]; other site 573370000813 G-X-G motif; other site 573370000814 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 573370000815 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 573370000816 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 573370000817 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 573370000818 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 573370000819 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 573370000820 active site 573370000821 SAM binding site [chemical binding]; other site 573370000822 homodimer interface [polypeptide binding]; other site 573370000823 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 573370000824 heme-binding residues [chemical binding]; other site 573370000825 Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372 573370000826 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 573370000827 EF hand; Region: EF-hand_5; pfam13202 573370000828 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 573370000829 active site 573370000830 catalytic site [active] 573370000831 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 573370000832 HAMP domain; Region: HAMP; pfam00672 573370000833 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 573370000834 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 573370000835 Walker A/P-loop; other site 573370000836 ATP binding site [chemical binding]; other site 573370000837 Q-loop/lid; other site 573370000838 ABC transporter signature motif; other site 573370000839 Walker B; other site 573370000840 D-loop; other site 573370000841 H-loop/switch region; other site 573370000842 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 573370000843 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370000844 dimerization interface [polypeptide binding]; other site 573370000845 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 573370000846 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370000847 putative active site [active] 573370000848 heme pocket [chemical binding]; other site 573370000849 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370000850 dimer interface [polypeptide binding]; other site 573370000851 phosphorylation site [posttranslational modification] 573370000852 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370000853 ATP binding site [chemical binding]; other site 573370000854 Mg2+ binding site [ion binding]; other site 573370000855 G-X-G motif; other site 573370000856 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 573370000857 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370000858 active site 573370000859 phosphorylation site [posttranslational modification] 573370000860 intermolecular recognition site; other site 573370000861 dimerization interface [polypeptide binding]; other site 573370000862 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573370000863 DNA binding site [nucleotide binding] 573370000864 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 573370000865 putative ligand binding site [chemical binding]; other site 573370000866 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370000867 dimerization interface [polypeptide binding]; other site 573370000868 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 573370000869 PAS domain; Region: PAS; smart00091 573370000870 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370000871 dimer interface [polypeptide binding]; other site 573370000872 phosphorylation site [posttranslational modification] 573370000873 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370000874 ATP binding site [chemical binding]; other site 573370000875 Mg2+ binding site [ion binding]; other site 573370000876 G-X-G motif; other site 573370000877 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370000878 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370000879 active site 573370000880 phosphorylation site [posttranslational modification] 573370000881 intermolecular recognition site; other site 573370000882 dimerization interface [polypeptide binding]; other site 573370000883 Zinc ribbon domain; Region: Zn-ribbon_8; cl00993 573370000884 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 573370000885 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573370000886 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573370000887 homodimer interface [polypeptide binding]; other site 573370000888 catalytic residue [active] 573370000889 cobyric acid synthase; Provisional; Region: PRK00784 573370000890 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573370000891 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 573370000892 catalytic triad [active] 573370000893 Cache domain; Region: Cache_1; pfam02743 573370000894 Domain of unknown function (DUF202); Region: DUF202; cl09954 573370000895 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 573370000896 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 573370000897 ring oligomerisation interface [polypeptide binding]; other site 573370000898 ATP/Mg binding site [chemical binding]; other site 573370000899 stacking interactions; other site 573370000900 hinge regions; other site 573370000901 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 573370000902 oligomerisation interface [polypeptide binding]; other site 573370000903 mobile loop; other site 573370000904 roof hairpin; other site 573370000905 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: HyfB; COG0651 573370000906 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 573370000907 NADH dehydrogenase; Region: NADHdh; cl00469 573370000908 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 573370000909 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl19197 573370000910 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 573370000911 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 573370000912 4Fe-4S dicluster domain; Region: Fer4_21; pfam14697 573370000913 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 573370000914 active site 573370000915 catalytic triad [active] 573370000916 oxyanion hole [active] 573370000917 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 573370000918 DNA polymerase III subunit delta'; Validated; Region: PRK08485 573370000919 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Validated; Region: PRK05537 573370000920 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 573370000921 active site 573370000922 KMSKS motif; other site 573370000923 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 573370000924 ligand-binding site [chemical binding]; other site 573370000925 CheD chemotactic sensory transduction; Region: CheD; cl00810 573370000926 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370000927 active site 573370000928 phosphorylation site [posttranslational modification] 573370000929 intermolecular recognition site; other site 573370000930 dimerization interface [polypeptide binding]; other site 573370000931 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 573370000932 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 573370000933 putative binding surface; other site 573370000934 active site 573370000935 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 573370000936 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370000937 ATP binding site [chemical binding]; other site 573370000938 Mg2+ binding site [ion binding]; other site 573370000939 G-X-G motif; other site 573370000940 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 573370000941 Uncharacterized conserved protein [Function unknown]; Region: COG3379 573370000942 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 573370000943 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 573370000944 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 573370000945 HlyD family secretion protein; Region: HlyD_3; pfam13437 573370000946 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 573370000947 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 573370000948 SLBB domain; Region: SLBB; pfam10531 573370000949 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 573370000950 PCI domain; Region: PCI; cl02111 573370000951 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 573370000952 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573370000953 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 573370000954 hypothetical protein; Provisional; Region: PRK07208 573370000955 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 573370000956 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573370000957 FeS/SAM binding site; other site 573370000958 Iron-sulfur cluster-binding domain; Region: SPASM; pfam13186 573370000959 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 573370000960 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 573370000961 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573370000962 Radical SAM superfamily; Region: Radical_SAM; pfam04055 573370000963 FeS/SAM binding site; other site 573370000964 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 573370000965 PAS domain S-box; Region: sensory_box; TIGR00229 573370000966 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370000967 putative active site [active] 573370000968 heme pocket [chemical binding]; other site 573370000969 GAF domain; Region: GAF; cl17456 573370000970 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370000971 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 573370000972 putative active site [active] 573370000973 heme pocket [chemical binding]; other site 573370000974 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370000975 dimer interface [polypeptide binding]; other site 573370000976 phosphorylation site [posttranslational modification] 573370000977 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370000978 ATP binding site [chemical binding]; other site 573370000979 Mg2+ binding site [ion binding]; other site 573370000980 G-X-G motif; other site 573370000981 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370000982 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370000983 active site 573370000984 phosphorylation site [posttranslational modification] 573370000985 intermolecular recognition site; other site 573370000986 dimerization interface [polypeptide binding]; other site 573370000987 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 573370000988 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573370000989 active site 573370000990 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573370000991 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 573370000992 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 573370000993 B12 binding domain; Region: B12-binding; pfam02310 573370000994 B12 binding site [chemical binding]; other site 573370000995 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573370000996 FeS/SAM binding site; other site 573370000997 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 573370000998 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 573370000999 Ligand binding site; other site 573370001000 Putative Catalytic site; other site 573370001001 DXD motif; other site 573370001002 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 573370001003 putative acyl-acceptor binding pocket; other site 573370001004 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 573370001005 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573370001006 Radical SAM superfamily; Region: Radical_SAM; pfam04055 573370001007 FeS/SAM binding site; other site 573370001008 B12 binding domain; Region: B12-binding; pfam02310 573370001009 B12 binding site [chemical binding]; other site 573370001010 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573370001011 Radical SAM superfamily; Region: Radical_SAM; pfam04055 573370001012 FeS/SAM binding site; other site 573370001013 Domain of unknown function (DUF362); Region: DUF362; pfam04015 573370001014 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 573370001015 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 573370001016 acyl-activating enzyme (AAE) consensus motif; other site 573370001017 AMP binding site [chemical binding]; other site 573370001018 active site 573370001019 CoA binding site [chemical binding]; other site 573370001020 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 573370001021 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 573370001022 putative active site [active] 573370001023 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573370001024 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573370001025 Walker A/P-loop; other site 573370001026 ATP binding site [chemical binding]; other site 573370001027 Q-loop/lid; other site 573370001028 ABC transporter signature motif; other site 573370001029 Walker B; other site 573370001030 D-loop; other site 573370001031 H-loop/switch region; other site 573370001032 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573370001033 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573370001034 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573370001035 Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; cl17183 573370001036 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573370001037 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 573370001038 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573370001039 Methyltransferase domain; Region: Methyltransf_24; pfam13578 573370001040 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 573370001041 Methyltransferase domain; Region: Methyltransf_24; pfam13578 573370001042 DEC-1 protein, N-terminal region; Region: DEC-1_N; pfam04625 573370001043 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 573370001044 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 573370001045 Radical SAM superfamily; Region: Radical_SAM; pfam04055 573370001046 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573370001047 FeS/SAM binding site; other site 573370001048 Uncharacterized ABC-type transport system, permease component [General function prediction only]; Region: COG1079 573370001049 TM-ABC transporter signature motif; other site 573370001050 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 573370001051 TM-ABC transporter signature motif; other site 573370001052 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 573370001053 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573370001054 Walker A/P-loop; other site 573370001055 ATP binding site [chemical binding]; other site 573370001056 Q-loop/lid; other site 573370001057 ABC transporter signature motif; other site 573370001058 Walker B; other site 573370001059 D-loop; other site 573370001060 H-loop/switch region; other site 573370001061 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573370001062 Walker A/P-loop; other site 573370001063 ATP binding site [chemical binding]; other site 573370001064 Q-loop/lid; other site 573370001065 ABC transporter signature motif; other site 573370001066 Walker B; other site 573370001067 D-loop; other site 573370001068 H-loop/switch region; other site 573370001069 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 573370001070 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 573370001071 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573370001072 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 573370001073 active site 573370001074 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 573370001075 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573370001076 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573370001077 putative metalloenzyme radical SAM/SPASM domain maturase; Region: rSAM_Geo_metal; TIGR04311 573370001078 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573370001079 FeS/SAM binding site; other site 573370001080 Iron-sulfur cluster-binding domain; Region: SPASM; pfam13186 573370001081 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 573370001082 GDP-binding site [chemical binding]; other site 573370001083 ACT binding site; other site 573370001084 IMP binding site; other site 573370001085 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 573370001086 RNB domain; Region: RNB; pfam00773 573370001087 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 573370001088 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 573370001089 active site 573370001090 oxyanion hole [active] 573370001091 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573370001092 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573370001093 non-specific DNA binding site [nucleotide binding]; other site 573370001094 salt bridge; other site 573370001095 sequence-specific DNA binding site [nucleotide binding]; other site 573370001096 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370001097 PAS fold; Region: PAS_3; pfam08447 573370001098 putative active site [active] 573370001099 heme pocket [chemical binding]; other site 573370001100 PAS fold; Region: PAS_4; pfam08448 573370001101 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370001102 putative active site [active] 573370001103 heme pocket [chemical binding]; other site 573370001104 PAS domain S-box; Region: sensory_box; TIGR00229 573370001105 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370001106 putative active site [active] 573370001107 heme pocket [chemical binding]; other site 573370001108 PAS fold; Region: PAS_4; pfam08448 573370001109 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370001110 putative active site [active] 573370001111 heme pocket [chemical binding]; other site 573370001112 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370001113 putative active site [active] 573370001114 heme pocket [chemical binding]; other site 573370001115 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573370001116 Zn2+ binding site [ion binding]; other site 573370001117 Mg2+ binding site [ion binding]; other site 573370001118 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573370001119 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573370001120 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 573370001121 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573370001122 potential protein location (hypothetical protein DMR_03420 [Desulfovibrio magneticus RS-1]) that overlaps RNA (23S ribosomal RNA) 573370001123 Uncharacterized alpha/beta hydrolase domain (DUF2235); Region: DUF2235; pfam09994 573370001124 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 573370001125 PAS domain S-box; Region: sensory_box; TIGR00229 573370001126 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370001127 putative active site [active] 573370001128 heme pocket [chemical binding]; other site 573370001129 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 573370001130 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370001131 putative active site [active] 573370001132 heme pocket [chemical binding]; other site 573370001133 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370001134 dimer interface [polypeptide binding]; other site 573370001135 phosphorylation site [posttranslational modification] 573370001136 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370001137 ATP binding site [chemical binding]; other site 573370001138 Mg2+ binding site [ion binding]; other site 573370001139 G-X-G motif; other site 573370001140 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370001141 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370001142 active site 573370001143 phosphorylation site [posttranslational modification] 573370001144 intermolecular recognition site; other site 573370001145 dimerization interface [polypeptide binding]; other site 573370001146 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 573370001147 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370001148 dimerization interface [polypeptide binding]; other site 573370001149 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370001150 metal binding site [ion binding]; metal-binding site 573370001151 active site 573370001152 I-site; other site 573370001153 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 573370001154 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573370001155 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573370001156 ABC transporter; Region: ABC_tran_2; pfam12848 573370001157 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573370001158 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 573370001159 putative active site [active] 573370001160 putative metal binding residues [ion binding]; other site 573370001161 signature motif; other site 573370001162 putative triphosphate binding site [ion binding]; other site 573370001163 dimer interface [polypeptide binding]; other site 573370001164 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 573370001165 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370001166 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573370001167 binding surface 573370001168 TPR motif; other site 573370001169 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 573370001170 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 573370001171 active site 1 [active] 573370001172 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 573370001173 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 573370001174 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 573370001175 Putative Fe-S cluster; Region: FeS; cl17515 573370001176 PAS domain; Region: PAS_8; pfam13188 573370001177 PAS domain; Region: PAS_9; pfam13426 573370001178 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 573370001179 dimer interface [polypeptide binding]; other site 573370001180 [2Fe-2S] cluster binding site [ion binding]; other site 573370001181 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 573370001182 homotrimer interaction site [polypeptide binding]; other site 573370001183 putative active site [active] 573370001184 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 573370001185 Acyltransferase family; Region: Acyl_transf_3; pfam01757 573370001186 sulfite reductase, dissimilatory-type alpha subunit; Region: dsrA; TIGR02064 573370001187 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 573370001188 sulfite reductase, dissimilatory-type beta subunit; Region: dsrB; TIGR02066 573370001189 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 573370001190 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 573370001191 Dissimilatory sulfite reductase D (DsrD); Region: DsrD; pfam08679 573370001192 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573370001193 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 573370001194 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 573370001195 catalytic triad [active] 573370001196 DNA polymerase I; Provisional; Region: PRK05755 573370001197 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 573370001198 active site 573370001199 metal binding site 1 [ion binding]; metal-binding site 573370001200 putative 5' ssDNA interaction site; other site 573370001201 metal binding site 3; metal-binding site 573370001202 metal binding site 2 [ion binding]; metal-binding site 573370001203 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 573370001204 putative DNA binding site [nucleotide binding]; other site 573370001205 putative metal binding site [ion binding]; other site 573370001206 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 573370001207 active site 573370001208 substrate binding site [chemical binding]; other site 573370001209 catalytic site [active] 573370001210 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 573370001211 active site 573370001212 DNA binding site [nucleotide binding] 573370001213 catalytic site [active] 573370001214 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 573370001215 Outer membrane efflux protein; Region: OEP; pfam02321 573370001216 Outer membrane efflux protein; Region: OEP; pfam02321 573370001217 Polysulphide reductase, NrfD; Region: NrfD; cl19193 573370001218 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 573370001219 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 573370001220 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 573370001221 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 573370001222 Cysteine-rich domain; Region: CCG; pfam02754 573370001223 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 573370001224 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 573370001225 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 573370001226 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 573370001227 active site 573370001228 Competence-damaged protein; Region: CinA; pfam02464 573370001229 seryl-tRNA synthetase; Provisional; Region: PRK05431 573370001230 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 573370001231 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 573370001232 dimer interface [polypeptide binding]; other site 573370001233 active site 573370001234 motif 1; other site 573370001235 motif 2; other site 573370001236 motif 3; other site 573370001237 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 573370001238 Zn binding site [ion binding]; other site 573370001239 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 573370001240 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 573370001241 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 573370001242 aminodeoxychorismate synthase; Provisional; Region: PRK07508 573370001243 chorismate binding enzyme; Region: Chorismate_bind; cl10555 573370001244 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 573370001245 substrate-cofactor binding pocket; other site 573370001246 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573370001247 catalytic residue [active] 573370001248 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 573370001249 ligand binding site [chemical binding]; other site 573370001250 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 573370001251 Glycoprotease family; Region: Peptidase_M22; pfam00814 573370001252 Uncharacterized protein conserved in archaea (DUF2240); Region: DUF2240; cl01449 573370001253 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 573370001254 RIP metalloprotease RseP; Region: TIGR00054 573370001255 active site 573370001256 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 573370001257 putative substrate binding region [chemical binding]; other site 573370001258 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 573370001259 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 573370001260 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 573370001261 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 573370001262 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 573370001263 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370001264 dimer interface [polypeptide binding]; other site 573370001265 phosphorylation site [posttranslational modification] 573370001266 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370001267 ATP binding site [chemical binding]; other site 573370001268 G-X-G motif; other site 573370001269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370001270 active site 573370001271 phosphorylation site [posttranslational modification] 573370001272 intermolecular recognition site; other site 573370001273 dimerization interface [polypeptide binding]; other site 573370001274 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370001275 S-adenosylmethionine binding site [chemical binding]; other site 573370001276 TolB amino-terminal domain; Region: TolB_N; pfam04052 573370001277 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 573370001278 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 573370001279 Herpes DNA replication accessory factor; Region: Herpes_DNAp_acc; pfam04929 573370001280 Yip1 domain; Region: Yip1; pfam04893 573370001281 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573370001282 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 573370001283 NUT protein N terminus; Region: NUT_N; pfam12881 573370001284 flagellar capping protein; Provisional; Region: PRK12765 573370001285 Flagellar hook-associated protein 2 N-terminus; Region: FliD_N; pfam02465 573370001286 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 573370001287 flagellin; Reviewed; Region: PRK08869 573370001288 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 573370001289 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 573370001290 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 573370001291 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370001292 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370001293 binding surface 573370001294 TPR motif; other site 573370001295 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370001296 TPR motif; other site 573370001297 TPR repeat; Region: TPR_11; pfam13414 573370001298 binding surface 573370001299 TPR repeat; Region: TPR_11; pfam13414 573370001300 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370001301 binding surface 573370001302 TPR motif; other site 573370001303 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 573370001304 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370001305 active site 573370001306 phosphorylation site [posttranslational modification] 573370001307 intermolecular recognition site; other site 573370001308 dimerization interface [polypeptide binding]; other site 573370001309 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 573370001310 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 573370001311 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370001312 putative active site [active] 573370001313 heme pocket [chemical binding]; other site 573370001314 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370001315 ATP binding site [chemical binding]; other site 573370001316 Mg2+ binding site [ion binding]; other site 573370001317 G-X-G motif; other site 573370001318 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 573370001319 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; cl19511 573370001320 TPR repeat; Region: TPR_11; pfam13414 573370001321 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573370001322 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370001323 binding surface 573370001324 TPR motif; other site 573370001325 TPR repeat; Region: TPR_11; pfam13414 573370001326 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 573370001327 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370001328 active site 573370001329 phosphorylation site [posttranslational modification] 573370001330 intermolecular recognition site; other site 573370001331 dimerization interface [polypeptide binding]; other site 573370001332 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573370001333 Zn2+ binding site [ion binding]; other site 573370001334 Mg2+ binding site [ion binding]; other site 573370001335 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 573370001336 Formin Homology Region 1; Region: Drf_FH1; pfam06346 573370001337 Bacterial protein of unknown function (DUF885); Region: DUF885; cl19872 573370001338 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 573370001339 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 573370001340 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl19067 573370001341 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 573370001342 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 573370001343 homodimer interaction site [polypeptide binding]; other site 573370001344 cofactor binding site; other site 573370001345 Cache domain; Region: Cache_2; pfam08269 573370001346 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 573370001347 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370001348 dimerization interface [polypeptide binding]; other site 573370001349 PAS domain; Region: PAS_9; pfam13426 573370001350 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370001351 putative active site [active] 573370001352 heme pocket [chemical binding]; other site 573370001353 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 573370001354 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370001355 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573370001356 dimer interface [polypeptide binding]; other site 573370001357 putative CheW interface [polypeptide binding]; other site 573370001358 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370001359 active site 573370001360 phosphorylation site [posttranslational modification] 573370001361 intermolecular recognition site; other site 573370001362 dimerization interface [polypeptide binding]; other site 573370001363 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 573370001364 MMPL family; Region: MMPL; cl14618 573370001365 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 573370001366 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 573370001367 HlyD family secretion protein; Region: HlyD_3; pfam13437 573370001368 Protein of unknown function DUF47; Region: PhoU_div; pfam01865 573370001369 TIGR00153 family protein; Region: TIGR00153 573370001370 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 573370001371 metal binding site 2 [ion binding]; metal-binding site 573370001372 putative DNA binding helix; other site 573370001373 metal binding site 1 [ion binding]; metal-binding site 573370001374 dimer interface [polypeptide binding]; other site 573370001375 structural Zn2+ binding site [ion binding]; other site 573370001376 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 573370001377 active site 573370001378 DNA polymerase IV; Validated; Region: PRK02406 573370001379 DNA binding site [nucleotide binding] 573370001380 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 573370001381 homodimer interface [polypeptide binding]; other site 573370001382 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 573370001383 active site pocket [active] 573370001384 putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054 573370001385 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573370001386 FeS/SAM binding site; other site 573370001387 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 573370001388 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 573370001389 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573370001390 Zn2+ binding site [ion binding]; other site 573370001391 Mg2+ binding site [ion binding]; other site 573370001392 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 573370001393 dimer interface [polypeptide binding]; other site 573370001394 active site 573370001395 Schiff base residues; other site 573370001396 hypothetical protein; Provisional; Region: PRK12473; cl11698 573370001397 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 573370001398 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573370001399 FeS/SAM binding site; other site 573370001400 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 573370001401 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 573370001402 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 573370001403 Walker A/P-loop; other site 573370001404 ATP binding site [chemical binding]; other site 573370001405 Q-loop/lid; other site 573370001406 ABC transporter signature motif; other site 573370001407 Walker B; other site 573370001408 D-loop; other site 573370001409 H-loop/switch region; other site 573370001410 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 573370001411 active site 573370001412 metal binding site [ion binding]; metal-binding site 573370001413 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 573370001414 Acyltransferase family; Region: Acyl_transf_3; pfam01757 573370001415 Predicted RNA binding protein (dsRBD-like fold), HicA family [General function prediction only]; Region: COG1724 573370001416 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 573370001417 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 573370001418 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 573370001419 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 573370001420 active site 573370001421 HIGH motif; other site 573370001422 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 573370001423 KMSKS motif; other site 573370001424 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 573370001425 tRNA binding surface [nucleotide binding]; other site 573370001426 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 573370001427 oligomeric interface; other site 573370001428 putative active site [active] 573370001429 homodimer interface [polypeptide binding]; other site 573370001430 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 573370001431 transcription antitermination factor NusB; Region: nusB; TIGR01951 573370001432 putative RNA binding site [nucleotide binding]; other site 573370001433 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 573370001434 homopentamer interface [polypeptide binding]; other site 573370001435 active site 573370001436 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 573370001437 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 573370001438 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 573370001439 dimerization interface [polypeptide binding]; other site 573370001440 active site 573370001441 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 573370001442 active site 573370001443 metal binding site [ion binding]; metal-binding site 573370001444 Protein of unknown function (DUF4019); Region: DUF4019; pfam13211 573370001445 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 573370001446 Lumazine binding domain; Region: Lum_binding; pfam00677 573370001447 Lumazine binding domain; Region: Lum_binding; pfam00677 573370001448 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 573370001449 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 573370001450 DNA binding site [nucleotide binding] 573370001451 active site 573370001452 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 573370001453 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 573370001454 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 573370001455 Catalytic site [active] 573370001456 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 573370001457 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 573370001458 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 573370001459 rod shape-determining protein MreB; Provisional; Region: PRK13927 573370001460 MreB and similar proteins; Region: MreB_like; cd10225 573370001461 nucleotide binding site [chemical binding]; other site 573370001462 Mg binding site [ion binding]; other site 573370001463 putative protofilament interaction site [polypeptide binding]; other site 573370001464 RodZ interaction site [polypeptide binding]; other site 573370001465 rod shape-determining protein MreC; Provisional; Region: PRK13922 573370001466 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 573370001467 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 573370001468 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 573370001469 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 573370001470 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 573370001471 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 573370001472 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 573370001473 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 573370001474 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 573370001475 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 573370001476 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 573370001477 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 573370001478 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 573370001479 beta subunit interaction interface [polypeptide binding]; other site 573370001480 Walker A motif; other site 573370001481 ATP binding site [chemical binding]; other site 573370001482 Walker B motif; other site 573370001483 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 573370001484 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 573370001485 core domain interface [polypeptide binding]; other site 573370001486 delta subunit interface [polypeptide binding]; other site 573370001487 epsilon subunit interface [polypeptide binding]; other site 573370001488 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 573370001489 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 573370001490 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 573370001491 alpha subunit interaction interface [polypeptide binding]; other site 573370001492 Walker A motif; other site 573370001493 ATP binding site [chemical binding]; other site 573370001494 Walker B motif; other site 573370001495 inhibitor binding site; inhibition site 573370001496 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 573370001497 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13446 573370001498 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 573370001499 gamma subunit interface [polypeptide binding]; other site 573370001500 epsilon subunit interface [polypeptide binding]; other site 573370001501 LBP interface [polypeptide binding]; other site 573370001502 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13446 573370001503 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 573370001504 gamma subunit interface [polypeptide binding]; other site 573370001505 epsilon subunit interface [polypeptide binding]; other site 573370001506 LBP interface [polypeptide binding]; other site 573370001507 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14356 573370001508 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 573370001509 Substrate binding site; other site 573370001510 Mg++ binding site; other site 573370001511 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 573370001512 active site 573370001513 substrate binding site [chemical binding]; other site 573370001514 CoA binding site [chemical binding]; other site 573370001515 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 573370001516 Cell division protein ZapA; Region: ZapA; pfam05164 573370001517 phosphodiesterase; Provisional; Region: PRK12704 573370001518 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 573370001519 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cd00105 573370001520 nucleic acid binding region [nucleotide binding]; other site 573370001521 G-X-X-G motif; other site 573370001522 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573370001523 Zn2+ binding site [ion binding]; other site 573370001524 Mg2+ binding site [ion binding]; other site 573370001525 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 573370001526 HSP70 interaction site [polypeptide binding]; other site 573370001527 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 573370001528 Zn binding sites [ion binding]; other site 573370001529 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 573370001530 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 573370001531 putative active site [active] 573370001532 metal binding site [ion binding]; metal-binding site 573370001533 homodimer binding site [polypeptide binding]; other site 573370001534 Sporulation related domain; Region: SPOR; pfam05036 573370001535 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 573370001536 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 573370001537 active site 573370001538 HIGH motif; other site 573370001539 dimer interface [polypeptide binding]; other site 573370001540 KMSKS motif; other site 573370001541 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 573370001542 RNA binding surface [nucleotide binding]; other site 573370001543 4-Hydroxybenzoate polyprenyltransferase; Region: PT_UbiA_COQ2; cd13959 573370001544 putative active site [active] 573370001545 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 573370001546 Mg++ binding site [ion binding]; other site 573370001547 putative catalytic motif [active] 573370001548 substrate binding site [chemical binding]; other site 573370001549 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573370001550 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 573370001551 putative ADP-binding pocket [chemical binding]; other site 573370001552 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 573370001553 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370001554 active site 573370001555 phosphorylation site [posttranslational modification] 573370001556 intermolecular recognition site; other site 573370001557 dimerization interface [polypeptide binding]; other site 573370001558 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370001559 active site 573370001560 phosphorylation site [posttranslational modification] 573370001561 intermolecular recognition site; other site 573370001562 dimerization interface [polypeptide binding]; other site 573370001563 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370001564 metal binding site [ion binding]; metal-binding site 573370001565 active site 573370001566 I-site; other site 573370001567 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370001568 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370001569 putative active site [active] 573370001570 heme pocket [chemical binding]; other site 573370001571 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370001572 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370001573 putative active site [active] 573370001574 heme pocket [chemical binding]; other site 573370001575 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370001576 putative active site [active] 573370001577 heme pocket [chemical binding]; other site 573370001578 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370001579 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 573370001580 putative active site [active] 573370001581 heme pocket [chemical binding]; other site 573370001582 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370001583 dimer interface [polypeptide binding]; other site 573370001584 phosphorylation site [posttranslational modification] 573370001585 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370001586 ATP binding site [chemical binding]; other site 573370001587 Mg2+ binding site [ion binding]; other site 573370001588 G-X-G motif; other site 573370001589 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 573370001590 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 573370001591 dimer interface [polypeptide binding]; other site 573370001592 catalytic triad [active] 573370001593 peroxidatic and resolving cysteines [active] 573370001594 Uncharacterized lipoprotein; Region: Lipoprotein_16; cl19472 573370001595 GTP-binding protein YchF; Reviewed; Region: PRK09601 573370001596 YchF GTPase; Region: YchF; cd01900 573370001597 G1 box; other site 573370001598 GTP/Mg2+ binding site [chemical binding]; other site 573370001599 Switch I region; other site 573370001600 G2 box; other site 573370001601 Switch II region; other site 573370001602 G3 box; other site 573370001603 G4 box; other site 573370001604 G5 box; other site 573370001605 Protein of unknown function (DUF933); Region: YchF-GTPase_C; pfam06071 573370001606 Precorrin-8X methylmutase; Region: CbiC; pfam02570 573370001607 ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266 573370001608 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 573370001609 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 573370001610 Bacterial PH domain; Region: bPH_4; cl19751 573370001611 EamA-like transporter family; Region: EamA; cl17759 573370001612 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 573370001613 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 573370001614 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 573370001615 acyl-activating enzyme (AAE) consensus motif; other site 573370001616 AMP binding site [chemical binding]; other site 573370001617 active site 573370001618 CoA binding site [chemical binding]; other site 573370001619 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 573370001620 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 573370001621 Flavodoxins [Energy production and conversion]; Region: FldA; COG0716 573370001622 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 573370001623 Protein of unknown function (DUF1847); Region: DUF1847; pfam08901 573370001624 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 573370001625 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 573370001626 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 573370001627 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 573370001628 Domain of unknown function (DUF1844); Region: DUF1844; pfam08899 573370001629 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 573370001630 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 573370001631 domain interfaces; other site 573370001632 active site 573370001633 MarC family integral membrane protein; Region: MarC; cl00919 573370001634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573370001635 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573370001636 putative substrate translocation pore; other site 573370001637 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 573370001638 PhoU domain; Region: PhoU; pfam01895 573370001639 PhoU domain; Region: PhoU; pfam01895 573370001640 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370001641 active site 573370001642 phosphorylation site [posttranslational modification] 573370001643 intermolecular recognition site; other site 573370001644 dimerization interface [polypeptide binding]; other site 573370001645 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370001646 active site 573370001647 phosphorylation site [posttranslational modification] 573370001648 intermolecular recognition site; other site 573370001649 dimerization interface [polypeptide binding]; other site 573370001650 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573370001651 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370001652 dimer interface [polypeptide binding]; other site 573370001653 phosphorylation site [posttranslational modification] 573370001654 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370001655 ATP binding site [chemical binding]; other site 573370001656 Mg2+ binding site [ion binding]; other site 573370001657 G-X-G motif; other site 573370001658 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 573370001659 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 573370001660 substrate binding site [chemical binding]; other site 573370001661 active site 573370001662 catalytic residues [active] 573370001663 heterodimer interface [polypeptide binding]; other site 573370001664 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 573370001665 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573370001666 catalytic residue [active] 573370001667 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 573370001668 active site 573370001669 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 573370001670 active site 573370001671 ribulose/triose binding site [chemical binding]; other site 573370001672 phosphate binding site [ion binding]; other site 573370001673 substrate (anthranilate) binding pocket [chemical binding]; other site 573370001674 product (indole) binding pocket [chemical binding]; other site 573370001675 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 573370001676 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 573370001677 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 573370001678 HEPN domain; Region: HEPN; cl00824 573370001679 Glutamine amidotransferase class-I; Region: GATase; pfam00117 573370001680 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 573370001681 glutamine binding [chemical binding]; other site 573370001682 catalytic triad [active] 573370001683 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 573370001684 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 573370001685 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 573370001686 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 573370001687 prephenate dehydrogenase; Provisional; Region: PRK06444 573370001688 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 573370001689 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 573370001690 hinge; other site 573370001691 active site 573370001692 Chorismate mutase type II; Region: CM_2; pfam01817 573370001693 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 573370001694 Prephenate dehydratase; Region: PDT; pfam00800 573370001695 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 573370001696 putative L-Phe binding site [chemical binding]; other site 573370001697 3-dehydroquinate synthase; Provisional; Region: PRK02290 573370001698 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 573370001699 putative active site; other site 573370001700 catalytic residue [active] 573370001701 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 573370001702 adenosine phosphosulphate reductase, beta subunit; Region: aprB; TIGR02060 573370001703 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 573370001704 Adenosine-5'-phosphosulfate reductase beta subunit; Region: APS-reductase_C; pfam12139 573370001705 adenosine phosphosulphate reductase, alpha subunit; Region: aprA; TIGR02061 573370001706 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 573370001707 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573370001708 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 573370001709 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 573370001710 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 573370001711 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 573370001712 CitB domain protein; Region: CitB; TIGR02484 573370001713 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 573370001714 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 573370001715 MAEBL; Provisional; Region: PTZ00121 573370001716 Cysteine-rich small domain; Region: zf-like; cl00946 573370001717 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 573370001718 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 573370001719 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 573370001720 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 573370001721 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573370001722 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 573370001723 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 573370001724 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573370001725 Zn2+ binding site [ion binding]; other site 573370001726 Mg2+ binding site [ion binding]; other site 573370001727 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 573370001728 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370001729 dimerization interface [polypeptide binding]; other site 573370001730 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 573370001731 dimer interface [polypeptide binding]; other site 573370001732 putative CheW interface [polypeptide binding]; other site 573370001733 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370001734 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573370001735 dimer interface [polypeptide binding]; other site 573370001736 putative CheW interface [polypeptide binding]; other site 573370001737 Transposase; Region: DEDD_Tnp_IS110; pfam01548 573370001738 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 573370001739 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 573370001740 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 573370001741 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 573370001742 putative active site [active] 573370001743 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 573370001744 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 573370001745 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 573370001746 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 573370001747 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 573370001748 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 573370001749 Uncharacterized conserved protein [Function unknown]; Region: COG0398 573370001750 photolyase PhrII; Region: phr2; TIGR00591 573370001751 DNA photolyase; Region: DNA_photolyase; pfam00875 573370001752 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 573370001753 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 573370001754 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 573370001755 homodimer interface [polypeptide binding]; other site 573370001756 metal binding site [ion binding]; metal-binding site 573370001757 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 573370001758 homodimer interface [polypeptide binding]; other site 573370001759 active site 573370001760 putative chemical substrate binding site [chemical binding]; other site 573370001761 Colicin V production protein; Region: Colicin_V; pfam02674 573370001762 Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string...; Region: H4; cl00074 573370001763 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 573370001764 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370001765 Walker A motif; other site 573370001766 ATP binding site [chemical binding]; other site 573370001767 Walker B motif; other site 573370001768 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 573370001769 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 573370001770 catalytic motif [active] 573370001771 Zn binding site [ion binding]; other site 573370001772 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 573370001773 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 573370001774 catalytic motif [active] 573370001775 Zn binding site [ion binding]; other site 573370001776 anion transporter; Region: dass; TIGR00785 573370001777 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 573370001778 transmembrane helices; other site 573370001779 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 573370001780 EVE domain; Region: EVE; cl00728 573370001781 PAS domain S-box; Region: sensory_box; TIGR00229 573370001782 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370001783 putative active site [active] 573370001784 heme pocket [chemical binding]; other site 573370001785 PAS domain; Region: PAS; smart00091 573370001786 PAS fold; Region: PAS_4; pfam08448 573370001787 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 573370001788 PAS domain; Region: PAS_8; pfam13188 573370001789 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370001790 dimer interface [polypeptide binding]; other site 573370001791 phosphorylation site [posttranslational modification] 573370001792 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370001793 ATP binding site [chemical binding]; other site 573370001794 Mg2+ binding site [ion binding]; other site 573370001795 G-X-G motif; other site 573370001796 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370001797 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370001798 active site 573370001799 phosphorylation site [posttranslational modification] 573370001800 intermolecular recognition site; other site 573370001801 dimerization interface [polypeptide binding]; other site 573370001802 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573370001803 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 573370001804 substrate binding pocket [chemical binding]; other site 573370001805 membrane-bound complex binding site; other site 573370001806 hinge residues; other site 573370001807 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370001808 dimer interface [polypeptide binding]; other site 573370001809 phosphorylation site [posttranslational modification] 573370001810 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370001811 ATP binding site [chemical binding]; other site 573370001812 Mg2+ binding site [ion binding]; other site 573370001813 G-X-G motif; other site 573370001814 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 573370001815 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370001816 active site 573370001817 phosphorylation site [posttranslational modification] 573370001818 intermolecular recognition site; other site 573370001819 dimerization interface [polypeptide binding]; other site 573370001820 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370001821 Walker A motif; other site 573370001822 ATP binding site [chemical binding]; other site 573370001823 Walker B motif; other site 573370001824 arginine finger; other site 573370001825 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 573370001826 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 573370001827 fumarate hydratase; Provisional; Region: PRK06246 573370001828 Fumarase C-terminus; Region: Fumerase_C; cl00795 573370001829 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 573370001830 fumarate reductase cytochrome b-556 subunit; Provisional; Region: PRK13554 573370001831 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 573370001832 Iron-sulfur protein interface; other site 573370001833 proximal heme binding site [chemical binding]; other site 573370001834 fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626 573370001835 L-aspartate oxidase; Provisional; Region: PRK06175 573370001836 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 573370001837 fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552 573370001838 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 573370001839 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 573370001840 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 573370001841 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 573370001842 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 573370001843 TM-ABC transporter signature motif; other site 573370001844 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 573370001845 TM-ABC transporter signature motif; other site 573370001846 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 573370001847 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 573370001848 Walker A/P-loop; other site 573370001849 ATP binding site [chemical binding]; other site 573370001850 Q-loop/lid; other site 573370001851 ABC transporter signature motif; other site 573370001852 Walker B; other site 573370001853 D-loop; other site 573370001854 H-loop/switch region; other site 573370001855 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 573370001856 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 573370001857 Walker A/P-loop; other site 573370001858 ATP binding site [chemical binding]; other site 573370001859 Q-loop/lid; other site 573370001860 ABC transporter signature motif; other site 573370001861 Walker B; other site 573370001862 D-loop; other site 573370001863 H-loop/switch region; other site 573370001864 Phosphate-starvation-inducible E; Region: PsiE; pfam06146 573370001865 Transcriptional regulator [Transcription]; Region: IclR; COG1414 573370001866 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 573370001867 Bacterial transcriptional regulator; Region: IclR; pfam01614 573370001868 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 573370001869 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 573370001870 putative ligand binding site [chemical binding]; other site 573370001871 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 573370001872 TM-ABC transporter signature motif; other site 573370001873 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 573370001874 TM-ABC transporter signature motif; other site 573370001875 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 573370001876 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 573370001877 Walker A/P-loop; other site 573370001878 ATP binding site [chemical binding]; other site 573370001879 Q-loop/lid; other site 573370001880 ABC transporter signature motif; other site 573370001881 Walker B; other site 573370001882 D-loop; other site 573370001883 H-loop/switch region; other site 573370001884 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 573370001885 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 573370001886 Walker A/P-loop; other site 573370001887 ATP binding site [chemical binding]; other site 573370001888 Q-loop/lid; other site 573370001889 ABC transporter signature motif; other site 573370001890 Walker B; other site 573370001891 D-loop; other site 573370001892 H-loop/switch region; other site 573370001893 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 573370001894 active site 573370001895 threonine dehydratase; Provisional; Region: PRK07334 573370001896 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 573370001897 tetramer interface [polypeptide binding]; other site 573370001898 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573370001899 catalytic residue [active] 573370001900 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 573370001901 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 573370001902 YcfA-like protein; Region: YcfA; cl00752 573370001903 Predicted membrane protein (DUF2238); Region: DUF2238; cl01464 573370001904 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 573370001905 putative MPT binding site; other site 573370001906 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 573370001907 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 573370001908 catalytic loop [active] 573370001909 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 573370001910 iron binding site [ion binding]; other site 573370001911 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 573370001912 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 573370001913 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 573370001914 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 573370001915 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 573370001916 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 573370001917 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 573370001918 Cysteine-rich domain; Region: CCG; pfam02754 573370001919 Cysteine-rich domain; Region: CCG; pfam02754 573370001920 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370001921 S-adenosylmethionine binding site [chemical binding]; other site 573370001922 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 573370001923 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 573370001924 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573370001925 FeS/SAM binding site; other site 573370001926 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 573370001927 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 573370001928 acyl-activating enzyme (AAE) consensus motif; other site 573370001929 active site 573370001930 AMP binding site [chemical binding]; other site 573370001931 CoA binding site [chemical binding]; other site 573370001932 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 573370001933 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 573370001934 XdhC Rossmann domain; Region: XdhC_C; pfam13478 573370001935 Putative zinc- or iron-chelating domain; Region: CxxCxxCC; pfam03692 573370001936 Protoglobin; Region: Protoglobin; pfam11563 573370001937 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370001938 metal binding site [ion binding]; metal-binding site 573370001939 active site 573370001940 I-site; other site 573370001941 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 573370001942 putative deacylase active site [active] 573370001943 Sulphur transport; Region: Sulf_transp; cl19477 573370001944 Sulphur transport; Region: Sulf_transp; cl19477 573370001945 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 573370001946 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 573370001947 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 573370001948 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 573370001949 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 573370001950 Methyltransferase domain; Region: Methyltransf_26; pfam13659 573370001951 Class I aldolases; Region: Aldolase_Class_I; cl17187 573370001952 catalytic residue [active] 573370001953 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 573370001954 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 573370001955 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370001956 dimerization interface [polypeptide binding]; other site 573370001957 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 573370001958 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 573370001959 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 573370001960 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 573370001961 Cl- selectivity filter; other site 573370001962 Cl- binding residues [ion binding]; other site 573370001963 pore gating glutamate residue; other site 573370001964 dimer interface [polypeptide binding]; other site 573370001965 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 573370001966 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 573370001967 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 573370001968 active site 573370001969 Riboflavin kinase; Region: Flavokinase; pfam01687 573370001970 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 573370001971 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 573370001972 active site 573370001973 catalytic triad [active] 573370001974 oxyanion hole [active] 573370001975 PilZ domain; Region: PilZ; pfam07238 573370001976 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 573370001977 Cytochrome c; Region: Cytochrom_C; cl11414 573370001978 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 573370001979 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 573370001980 PAS domain S-box; Region: sensory_box; TIGR00229 573370001981 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370001982 putative active site [active] 573370001983 heme pocket [chemical binding]; other site 573370001984 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 573370001985 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370001986 dimer interface [polypeptide binding]; other site 573370001987 phosphorylation site [posttranslational modification] 573370001988 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370001989 ATP binding site [chemical binding]; other site 573370001990 Mg2+ binding site [ion binding]; other site 573370001991 G-X-G motif; other site 573370001992 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370001993 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370001994 active site 573370001995 phosphorylation site [posttranslational modification] 573370001996 intermolecular recognition site; other site 573370001997 dimerization interface [polypeptide binding]; other site 573370001998 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 573370001999 putative binding surface; other site 573370002000 active site 573370002001 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 573370002002 active site 573370002003 catalytic triad [active] 573370002004 oxyanion hole [active] 573370002005 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 573370002006 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 573370002007 Transglycosylase SLT domain; Region: SLT_2; pfam13406 573370002008 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 573370002009 N-acetyl-D-glucosamine binding site [chemical binding]; other site 573370002010 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 573370002011 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370002012 active site 573370002013 phosphorylation site [posttranslational modification] 573370002014 intermolecular recognition site; other site 573370002015 dimerization interface [polypeptide binding]; other site 573370002016 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370002017 Walker A motif; other site 573370002018 ATP binding site [chemical binding]; other site 573370002019 Walker B motif; other site 573370002020 arginine finger; other site 573370002021 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 573370002022 EF-hand domain pair; Region: EF-hand_7; pfam13499 573370002023 Ca2+ binding site [ion binding]; other site 573370002024 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370002025 binding surface 573370002026 TPR repeat; Region: TPR_11; pfam13414 573370002027 TPR motif; other site 573370002028 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 573370002029 CoenzymeA binding site [chemical binding]; other site 573370002030 subunit interaction site [polypeptide binding]; other site 573370002031 PHB binding site; other site 573370002032 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 573370002033 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 573370002034 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 573370002035 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 573370002036 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 573370002037 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 573370002038 Citrate transporter; Region: CitMHS; pfam03600 573370002039 transmembrane helices; other site 573370002040 FOG: CBS domain [General function prediction only]; Region: COG0517 573370002041 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 573370002042 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 573370002043 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 573370002044 dimerization interface [polypeptide binding]; other site 573370002045 ligand binding site [chemical binding]; other site 573370002046 NADP binding site [chemical binding]; other site 573370002047 catalytic site [active] 573370002048 Right handed beta helix region; Region: Beta_helix; pfam13229 573370002049 Peptidase family M48; Region: Peptidase_M48; cl12018 573370002050 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 573370002051 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573370002052 Coenzyme A binding pocket [chemical binding]; other site 573370002053 VanZ like family; Region: VanZ; cl01971 573370002054 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cl19048 573370002055 Cytochrome c552; Region: Cytochrom_C552; pfam02335 573370002056 Autotransporter beta-domain; Region: Autotransporter; smart00869 573370002057 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 573370002058 Ligand Binding Site [chemical binding]; other site 573370002059 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 573370002060 active site 573370002061 catalytic residues [active] 573370002062 DNA binding site [nucleotide binding] 573370002063 Int/Topo IB signature motif; other site 573370002064 TOBE domain; Region: TOBE; cl01440 573370002065 TOBE domain; Region: TOBE; cl01440 573370002066 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 573370002067 homotrimer interaction site [polypeptide binding]; other site 573370002068 putative active site [active] 573370002069 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 573370002070 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 573370002071 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 573370002072 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 573370002073 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 573370002074 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 573370002075 HicB family; Region: HicB; pfam05534 573370002076 acetyl-CoA synthetase; Provisional; Region: PRK00174 573370002077 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 573370002078 acyl-activating enzyme (AAE) consensus motif; other site 573370002079 AMP binding site [chemical binding]; other site 573370002080 active site 573370002081 CoA binding site [chemical binding]; other site 573370002082 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 573370002083 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370002084 active site 573370002085 phosphorylation site [posttranslational modification] 573370002086 intermolecular recognition site; other site 573370002087 dimerization interface [polypeptide binding]; other site 573370002088 LytTr DNA-binding domain; Region: LytTR; smart00850 573370002089 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 573370002090 Walker A motif; other site 573370002091 ATP binding site [chemical binding]; other site 573370002092 Walker B motif; other site 573370002093 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 573370002094 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 573370002095 Walker A motif; other site 573370002096 ATP binding site [chemical binding]; other site 573370002097 Walker B motif; other site 573370002098 Helix-turn-helix domain; Region: HTH_17; cl17695 573370002099 Kappa casein; Region: Casein_kappa; pfam00997 573370002100 type IV pilus assembly protein PilM; Region: pilM; TIGR01175 573370002101 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 573370002102 type IV pilus biogenesis protein PilP; Region: pilP_fam; TIGR03021 573370002103 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 573370002104 Secretin and TonB N terminus short domain; Region: STN; pfam07660 573370002105 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 573370002106 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 573370002107 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 573370002108 AAA domain; Region: AAA_22; pfam13401 573370002109 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 573370002110 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 573370002111 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 573370002112 Walker A motif; other site 573370002113 ATP binding site [chemical binding]; other site 573370002114 Walker B motif; other site 573370002115 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 573370002116 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 573370002117 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 573370002118 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 573370002119 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370002120 Walker A motif; other site 573370002121 ATP binding site [chemical binding]; other site 573370002122 Walker B motif; other site 573370002123 arginine finger; other site 573370002124 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 573370002125 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 573370002126 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 573370002127 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370002128 TPR motif; other site 573370002129 binding surface 573370002130 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370002131 binding surface 573370002132 TPR motif; other site 573370002133 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370002134 binding surface 573370002135 TPR motif; other site 573370002136 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 573370002137 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 573370002138 legume lectins; Region: lectin_L-type; cl14058 573370002139 carbohydrate binding site [chemical binding]; other site 573370002140 metal binding site [ion binding]; metal-binding site 573370002141 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 573370002142 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 573370002143 N-acetyl-D-glucosamine binding site [chemical binding]; other site 573370002144 catalytic residue [active] 573370002145 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 573370002146 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 573370002147 Transglycosylase SLT domain; Region: SLT_2; pfam13406 573370002148 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 573370002149 N-acetyl-D-glucosamine binding site [chemical binding]; other site 573370002150 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 573370002151 Transposase; Region: DEDD_Tnp_IS110; pfam01548 573370002152 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 573370002153 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 573370002154 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 573370002155 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 573370002156 P-loop; other site 573370002157 Magnesium ion binding site [ion binding]; other site 573370002158 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133 573370002159 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 573370002160 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 573370002161 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370002162 S-adenosylmethionine binding site [chemical binding]; other site 573370002163 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370002164 S-adenosylmethionine binding site [chemical binding]; other site 573370002165 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 573370002166 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 573370002167 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 573370002168 UbiA family of prenyltransferases (PTases); Region: PT_UbiA; cd13956 573370002169 putative active site [active] 573370002170 PAS fold; Region: PAS_4; pfam08448 573370002171 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 573370002172 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370002173 putative active site [active] 573370002174 heme pocket [chemical binding]; other site 573370002175 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 573370002176 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370002177 dimer interface [polypeptide binding]; other site 573370002178 phosphorylation site [posttranslational modification] 573370002179 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370002180 ATP binding site [chemical binding]; other site 573370002181 Mg2+ binding site [ion binding]; other site 573370002182 G-X-G motif; other site 573370002183 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 573370002184 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 573370002185 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370002186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370002187 active site 573370002188 phosphorylation site [posttranslational modification] 573370002189 intermolecular recognition site; other site 573370002190 dimerization interface [polypeptide binding]; other site 573370002191 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370002192 dimerization interface [polypeptide binding]; other site 573370002193 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 573370002194 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 573370002195 Part of AAA domain; Region: AAA_19; pfam13245 573370002196 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 573370002197 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 573370002198 Uncharacterized conserved protein [Function unknown]; Region: COG3379 573370002199 Hemerythrin; Region: Hemerythrin; cd12107 573370002200 Fe binding site [ion binding]; other site 573370002201 AAA domain; Region: AAA_25; pfam13481 573370002202 Walker A motif; other site 573370002203 ATP binding site [chemical binding]; other site 573370002204 Walker B motif; other site 573370002205 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 573370002206 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 573370002207 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 573370002208 active site 573370002209 catalytic residues [active] 573370002210 DNA binding site [nucleotide binding] 573370002211 Int/Topo IB signature motif; other site 573370002212 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 573370002213 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573370002214 motif II; other site 573370002215 integrase; Provisional; Region: int; PHA02601 573370002216 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573370002217 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl19391 573370002218 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 573370002219 Motility quorum-sensing regulator (MqsR); Region: MqsR; cd12869 573370002220 peptide binding site [polypeptide binding]; other site 573370002221 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 573370002222 YgiT-type zinc finger domain; Region: YgiT_finger; TIGR03831 573370002223 Zn binding site [ion binding]; other site 573370002224 toxin interface [polypeptide binding]; other site 573370002225 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573370002226 non-specific DNA binding site [nucleotide binding]; other site 573370002227 salt bridge; other site 573370002228 sequence-specific DNA binding site [nucleotide binding]; other site 573370002229 Methyltransferase domain; Region: Methyltransf_31; pfam13847 573370002230 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370002231 S-adenosylmethionine binding site [chemical binding]; other site 573370002232 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 573370002233 Arylsulfotransferase (ASST); Region: Arylsulfotrans; cl19972 573370002234 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 573370002235 enterobactin exporter EntS; Provisional; Region: PRK10489 573370002236 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573370002237 putative substrate translocation pore; other site 573370002238 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 573370002239 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573370002240 catalytic residue [active] 573370002241 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 573370002242 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370002243 metal binding site [ion binding]; metal-binding site 573370002244 active site 573370002245 I-site; other site 573370002246 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 573370002247 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 573370002248 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 573370002249 NAD(P) binding site [chemical binding]; other site 573370002250 shikimate binding site; other site 573370002251 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 573370002252 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 573370002253 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 573370002254 TPP-binding site [chemical binding]; other site 573370002255 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 573370002256 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 573370002257 dimer interface [polypeptide binding]; other site 573370002258 PYR/PP interface [polypeptide binding]; other site 573370002259 TPP binding site [chemical binding]; other site 573370002260 substrate binding site [chemical binding]; other site 573370002261 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 573370002262 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 573370002263 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 573370002264 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 573370002265 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 573370002266 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 573370002267 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 573370002268 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 573370002269 ligand binding site [chemical binding]; other site 573370002270 flagellar motor protein MotA; Validated; Region: PRK09110 573370002271 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 573370002272 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573370002273 ATP binding site [chemical binding]; other site 573370002274 putative Mg++ binding site [ion binding]; other site 573370002275 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 573370002276 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573370002277 nucleotide binding region [chemical binding]; other site 573370002278 ATP-binding site [chemical binding]; other site 573370002279 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 573370002280 SEC-C motif; Region: SEC-C; pfam02810 573370002281 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 573370002282 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 573370002283 Cysteine-rich domain; Region: CCG; pfam02754 573370002284 Cysteine-rich domain; Region: CCG; pfam02754 573370002285 FAD binding domain; Region: FAD_binding_4; pfam01565 573370002286 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 573370002287 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 573370002288 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 573370002289 SmpB-tmRNA interface; other site 573370002290 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 573370002291 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 573370002292 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 573370002293 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 573370002294 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 573370002295 dimerization domain swap beta strand [polypeptide binding]; other site 573370002296 regulatory protein interface [polypeptide binding]; other site 573370002297 active site 573370002298 regulatory phosphorylation site [posttranslational modification]; other site 573370002299 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 573370002300 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 573370002301 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 573370002302 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 573370002303 Probable Catalytic site; other site 573370002304 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370002305 S-adenosylmethionine binding site [chemical binding]; other site 573370002306 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 573370002307 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 573370002308 Ligand binding site; other site 573370002309 Putative Catalytic site; other site 573370002310 DXD motif; other site 573370002311 WxcM-like, C-terminal; Region: FdtA; pfam05523 573370002312 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 573370002313 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 573370002314 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; cl19130 573370002315 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 573370002316 inhibitor-cofactor binding pocket; inhibition site 573370002317 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573370002318 catalytic residue [active] 573370002319 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 573370002320 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 573370002321 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 573370002322 molybdopterin cofactor binding site; other site 573370002323 The MopB_CT_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. This...; Region: MopB_CT_Acetylene-hydratase; cd02781 573370002324 putative molybdopterin cofactor binding site; other site 573370002325 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 573370002326 homodimer interface [polypeptide binding]; other site 573370002327 substrate-cofactor binding pocket; other site 573370002328 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573370002329 catalytic residue [active] 573370002330 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 573370002331 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 573370002332 catalytic triad [active] 573370002333 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 573370002334 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 573370002335 active site 573370002336 catalytic triad [active] 573370002337 oxyanion hole [active] 573370002338 LrgB-like family; Region: LrgB; cl00596 573370002339 LrgA family; Region: LrgA; pfam03788 573370002340 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573370002341 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573370002342 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 573370002343 putative dimerization interface [polypeptide binding]; other site 573370002344 peroxiredoxin; Region: AhpC; TIGR03137 573370002345 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 573370002346 dimer interface [polypeptide binding]; other site 573370002347 decamer (pentamer of dimers) interface [polypeptide binding]; other site 573370002348 catalytic triad [active] 573370002349 peroxidatic and resolving cysteines [active] 573370002350 Bacterial SH3 domain; Region: SH3_3; cl17532 573370002351 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 573370002352 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370002353 dimerization interface [polypeptide binding]; other site 573370002354 Uncharacterized conserved protein [Function unknown]; Region: COG5613; cl19899 573370002355 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370002356 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573370002357 dimer interface [polypeptide binding]; other site 573370002358 putative CheW interface [polypeptide binding]; other site 573370002359 Domain of unknown function (DUF362); Region: DUF362; pfam04015 573370002360 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 573370002361 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 573370002362 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 573370002363 TRAM domain; Region: TRAM; pfam01938 573370002364 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370002365 S-adenosylmethionine binding site [chemical binding]; other site 573370002366 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 573370002367 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370002368 dimer interface [polypeptide binding]; other site 573370002369 phosphorylation site [posttranslational modification] 573370002370 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370002371 ATP binding site [chemical binding]; other site 573370002372 Mg2+ binding site [ion binding]; other site 573370002373 G-X-G motif; other site 573370002374 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573370002375 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370002376 dimerization interface [polypeptide binding]; other site 573370002377 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370002378 dimer interface [polypeptide binding]; other site 573370002379 phosphorylation site [posttranslational modification] 573370002380 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370002381 ATP binding site [chemical binding]; other site 573370002382 Mg2+ binding site [ion binding]; other site 573370002383 G-X-G motif; other site 573370002384 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370002385 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370002386 active site 573370002387 phosphorylation site [posttranslational modification] 573370002388 intermolecular recognition site; other site 573370002389 dimerization interface [polypeptide binding]; other site 573370002390 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573370002391 DNA binding site [nucleotide binding] 573370002392 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 573370002393 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 573370002394 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 573370002395 catalytic loop [active] 573370002396 iron binding site [ion binding]; other site 573370002397 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 573370002398 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 573370002399 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 573370002400 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 573370002401 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 573370002402 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 573370002403 dimer interface [polypeptide binding]; other site 573370002404 [2Fe-2S] cluster binding site [ion binding]; other site 573370002405 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 573370002406 dimer interface [polypeptide binding]; other site 573370002407 [2Fe-2S] cluster binding site [ion binding]; other site 573370002408 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 573370002409 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 573370002410 SLBB domain; Region: SLBB; pfam10531 573370002411 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 573370002412 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 573370002413 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 573370002414 Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257 573370002415 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 573370002416 putative dimer interface [polypeptide binding]; other site 573370002417 [2Fe-2S] cluster binding site [ion binding]; other site 573370002418 PAS domain S-box; Region: sensory_box; TIGR00229 573370002419 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370002420 putative active site [active] 573370002421 heme pocket [chemical binding]; other site 573370002422 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370002423 dimer interface [polypeptide binding]; other site 573370002424 phosphorylation site [posttranslational modification] 573370002425 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370002426 ATP binding site [chemical binding]; other site 573370002427 Mg2+ binding site [ion binding]; other site 573370002428 G-X-G motif; other site 573370002429 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370002430 active site 573370002431 phosphorylation site [posttranslational modification] 573370002432 intermolecular recognition site; other site 573370002433 dimerization interface [polypeptide binding]; other site 573370002434 glutamate racemase; Provisional; Region: PRK00865 573370002435 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 573370002436 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 573370002437 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl19197 573370002438 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 573370002439 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl19174 573370002440 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 573370002441 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 573370002442 NADH dehydrogenase; Region: NADHdh; cl00469 573370002443 hydrogenase 4 subunit B; Validated; Region: PRK06521 573370002444 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 573370002445 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370002446 PAS domain; Region: PAS_9; pfam13426 573370002447 putative active site [active] 573370002448 heme pocket [chemical binding]; other site 573370002449 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 573370002450 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370002451 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573370002452 dimer interface [polypeptide binding]; other site 573370002453 putative CheW interface [polypeptide binding]; other site 573370002454 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573370002455 GeoRSP system radical SAM/SPASM protein; Region: GeoRSP_rSAM; TIGR04303 573370002456 FeS/SAM binding site; other site 573370002457 Methyltransferase domain; Region: Methyltransf_31; pfam13847 573370002458 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370002459 S-adenosylmethionine binding site [chemical binding]; other site 573370002460 SEC-C motif; Region: SEC-C; cl19389 573370002461 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 573370002462 SEC-C motif; Region: SEC-C; cl19389 573370002463 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370002464 S-adenosylmethionine binding site [chemical binding]; other site 573370002465 Predicted periplasmic protein (DUF2092); Region: DUF2092; cl17607 573370002466 PSP1 C-terminal conserved region; Region: PSP1; cl00770 573370002467 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 573370002468 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 573370002469 active site 573370002470 HIGH motif; other site 573370002471 KMSKS motif; other site 573370002472 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 573370002473 tRNA binding surface [nucleotide binding]; other site 573370002474 anticodon binding site; other site 573370002475 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 573370002476 dimer interface [polypeptide binding]; other site 573370002477 putative tRNA-binding site [nucleotide binding]; other site 573370002478 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370002479 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 573370002480 dimer interface [polypeptide binding]; other site 573370002481 putative CheW interface [polypeptide binding]; other site 573370002482 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 573370002483 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370002484 metal binding site [ion binding]; metal-binding site 573370002485 active site 573370002486 I-site; other site 573370002487 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 573370002488 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 573370002489 domain interfaces; other site 573370002490 active site 573370002491 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 573370002492 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 573370002493 dimer interface [polypeptide binding]; other site 573370002494 active site 573370002495 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 573370002496 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 573370002497 ADP binding site [chemical binding]; other site 573370002498 magnesium binding site [ion binding]; other site 573370002499 putative shikimate binding site; other site 573370002500 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl18995 573370002501 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 573370002502 DevC protein; Region: devC; TIGR01185 573370002503 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573370002504 FtsX-like permease family; Region: FtsX; pfam02687 573370002505 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 573370002506 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 573370002507 Walker A/P-loop; other site 573370002508 ATP binding site [chemical binding]; other site 573370002509 Q-loop/lid; other site 573370002510 ABC transporter signature motif; other site 573370002511 Walker B; other site 573370002512 D-loop; other site 573370002513 H-loop/switch region; other site 573370002514 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 573370002515 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 573370002516 HlyD family secretion protein; Region: HlyD_3; pfam13437 573370002517 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 573370002518 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 573370002519 N-acetyl-D-glucosamine binding site [chemical binding]; other site 573370002520 catalytic residue [active] 573370002521 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 573370002522 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 573370002523 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 573370002524 putative MPT binding site; other site 573370002525 Transcriptional regulators [Transcription]; Region: MarR; COG1846 573370002526 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 573370002527 putative DNA binding site [nucleotide binding]; other site 573370002528 putative Zn2+ binding site [ion binding]; other site 573370002529 thiosulfate reductase PhsA; Provisional; Region: PRK15488 573370002530 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 573370002531 molybdopterin cofactor binding site; other site 573370002532 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 573370002533 putative molybdopterin cofactor binding site; other site 573370002534 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 573370002535 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 573370002536 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 573370002537 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 573370002538 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl19151 573370002539 Methyltransferase domain; Region: Methyltransf_24; pfam13578 573370002540 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 573370002541 anti sigma factor interaction site; other site 573370002542 regulatory phosphorylation site [posttranslational modification]; other site 573370002543 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370002544 metal binding site [ion binding]; metal-binding site 573370002545 active site 573370002546 I-site; other site 573370002547 Iron-containing alcohol dehydrogenase; Region: Fe-ADH8; cd08186 573370002548 putative active site [active] 573370002549 metal binding site [ion binding]; metal-binding site 573370002550 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 573370002551 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573370002552 putative substrate translocation pore; other site 573370002553 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 573370002554 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 573370002555 HlyD family secretion protein; Region: HlyD_3; pfam13437 573370002556 Transcriptional regulators [Transcription]; Region: MarR; COG1846 573370002557 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 573370002558 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 573370002559 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 573370002560 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 573370002561 Clostridial binary toxin B/anthrax toxin PA; Region: Binary_toxB; pfam03495 573370002562 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 573370002563 active site 573370002564 Cache domain; Region: Cache_1; pfam02743 573370002565 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370002566 dimerization interface [polypeptide binding]; other site 573370002567 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370002568 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573370002569 dimer interface [polypeptide binding]; other site 573370002570 putative CheW interface [polypeptide binding]; other site 573370002571 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573370002572 active site 573370002573 Sulfate transporter family; Region: Sulfate_transp; cl19250 573370002574 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 573370002575 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 573370002576 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 573370002577 PilZ domain; Region: PilZ; pfam07238 573370002578 chitooligosaccharide synthase NodC; Region: nodulat_NodC; TIGR04242 573370002579 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 573370002580 DXD motif; other site 573370002581 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 573370002582 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 573370002583 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370002584 binding surface 573370002585 TPR motif; other site 573370002586 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 573370002587 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370002588 TPR motif; other site 573370002589 binding surface 573370002590 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370002591 binding surface 573370002592 TPR motif; other site 573370002593 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370002594 TPR motif; other site 573370002595 binding surface 573370002596 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370002597 TPR motif; other site 573370002598 binding surface 573370002599 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 573370002600 active site 573370002601 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 573370002602 Rubrerythrin [Energy production and conversion]; Region: COG1592 573370002603 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 573370002604 binuclear metal center [ion binding]; other site 573370002605 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 573370002606 iron binding site [ion binding]; other site 573370002607 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 573370002608 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 573370002609 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 573370002610 catalytic residues [active] 573370002611 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 573370002612 homodimer interface [polypeptide binding]; other site 573370002613 substrate-cofactor binding pocket; other site 573370002614 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573370002615 catalytic residue [active] 573370002616 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 573370002617 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl19058 573370002618 active site 573370002619 dimer interface [polypeptide binding]; other site 573370002620 YibE/F-like protein; Region: YibE_F; pfam07907 573370002621 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 573370002622 Hemerythrin; Region: Hemerythrin; cd12107 573370002623 Fe binding site [ion binding]; other site 573370002624 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370002625 PAS domain; Region: PAS_9; pfam13426 573370002626 putative active site [active] 573370002627 heme pocket [chemical binding]; other site 573370002628 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370002629 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 573370002630 dimer interface [polypeptide binding]; other site 573370002631 putative CheW interface [polypeptide binding]; other site 573370002632 Putative lysophospholipase; Region: Hydrolase_4; cl19140 573370002633 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 573370002634 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 573370002635 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370002636 dimerization interface [polypeptide binding]; other site 573370002637 PAS domain; Region: PAS_8; pfam13188 573370002638 PAS fold; Region: PAS_7; pfam12860 573370002639 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370002640 dimer interface [polypeptide binding]; other site 573370002641 phosphorylation site [posttranslational modification] 573370002642 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 573370002643 TIGR00153 family protein; Region: TIGR00153 573370002644 Phosphate transporter family; Region: PHO4; pfam01384 573370002645 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; cl19880 573370002646 Cache domain; Region: Cache_1; pfam02743 573370002647 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370002648 dimerization interface [polypeptide binding]; other site 573370002649 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 573370002650 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 573370002651 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 573370002652 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 573370002653 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 573370002654 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 573370002655 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573370002656 FeS/SAM binding site; other site 573370002657 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 573370002658 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 573370002659 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 573370002660 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 573370002661 putative NAD(P) binding site [chemical binding]; other site 573370002662 putative active site [active] 573370002663 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 573370002664 Chemoreceptor zinc-binding domain; Region: CZB; pfam13682 573370002665 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370002666 dimerization interface [polypeptide binding]; other site 573370002667 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370002668 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573370002669 dimer interface [polypeptide binding]; other site 573370002670 putative CheW interface [polypeptide binding]; other site 573370002671 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 573370002672 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 573370002673 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370002674 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370002675 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370002676 putative active site [active] 573370002677 heme pocket [chemical binding]; other site 573370002678 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370002679 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370002680 putative active site [active] 573370002681 heme pocket [chemical binding]; other site 573370002682 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370002683 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370002684 putative active site [active] 573370002685 heme pocket [chemical binding]; other site 573370002686 GAF domain; Region: GAF_2; pfam13185 573370002687 PAS domain S-box; Region: sensory_box; TIGR00229 573370002688 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370002689 putative active site [active] 573370002690 heme pocket [chemical binding]; other site 573370002691 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370002692 dimer interface [polypeptide binding]; other site 573370002693 phosphorylation site [posttranslational modification] 573370002694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370002695 ATP binding site [chemical binding]; other site 573370002696 Mg2+ binding site [ion binding]; other site 573370002697 G-X-G motif; other site 573370002698 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370002699 active site 573370002700 phosphorylation site [posttranslational modification] 573370002701 intermolecular recognition site; other site 573370002702 dimerization interface [polypeptide binding]; other site 573370002703 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 573370002704 putative hydrophobic ligand binding site [chemical binding]; other site 573370002705 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 573370002706 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 573370002707 active site 573370002708 catalytic residues [active] 573370002709 DNA binding site [nucleotide binding] 573370002710 Int/Topo IB signature motif; other site 573370002711 Helix-turn-helix domain; Region: HTH_17; pfam12728 573370002712 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573370002713 active site 573370002714 DNA binding site [nucleotide binding] 573370002715 Int/Topo IB signature motif; other site 573370002716 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 573370002717 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370002718 active site 573370002719 phosphorylation site [posttranslational modification] 573370002720 intermolecular recognition site; other site 573370002721 dimerization interface [polypeptide binding]; other site 573370002722 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573370002723 Zn2+ binding site [ion binding]; other site 573370002724 Mg2+ binding site [ion binding]; other site 573370002725 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573370002726 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370002727 active site 573370002728 phosphorylation site [posttranslational modification] 573370002729 intermolecular recognition site; other site 573370002730 dimerization interface [polypeptide binding]; other site 573370002731 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 573370002732 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573370002733 substrate binding pocket [chemical binding]; other site 573370002734 membrane-bound complex binding site; other site 573370002735 hinge residues; other site 573370002736 PAS domain; Region: PAS_8; pfam13188 573370002737 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370002738 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370002739 putative active site [active] 573370002740 heme pocket [chemical binding]; other site 573370002741 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 573370002742 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370002743 putative active site [active] 573370002744 heme pocket [chemical binding]; other site 573370002745 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370002746 dimer interface [polypeptide binding]; other site 573370002747 phosphorylation site [posttranslational modification] 573370002748 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370002749 ATP binding site [chemical binding]; other site 573370002750 Mg2+ binding site [ion binding]; other site 573370002751 G-X-G motif; other site 573370002752 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 573370002753 catalytic residues [active] 573370002754 Methyltransferase domain; Region: Methyltransf_24; pfam13578 573370002755 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 573370002756 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 573370002757 PhnA protein; Region: PhnA; pfam03831 573370002758 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 573370002759 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 573370002760 acyl-activating enzyme (AAE) consensus motif; other site 573370002761 AMP binding site [chemical binding]; other site 573370002762 active site 573370002763 CoA binding site [chemical binding]; other site 573370002764 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 573370002765 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 573370002766 Walker A/P-loop; other site 573370002767 ATP binding site [chemical binding]; other site 573370002768 Q-loop/lid; other site 573370002769 ABC transporter signature motif; other site 573370002770 Walker B; other site 573370002771 D-loop; other site 573370002772 H-loop/switch region; other site 573370002773 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 573370002774 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 573370002775 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 573370002776 TM-ABC transporter signature motif; other site 573370002777 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 573370002778 TM-ABC transporter signature motif; other site 573370002779 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 573370002780 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 573370002781 acyl-activating enzyme (AAE) consensus motif; other site 573370002782 putative AMP binding site [chemical binding]; other site 573370002783 putative active site [active] 573370002784 putative CoA binding site [chemical binding]; other site 573370002785 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 573370002786 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 573370002787 Walker A/P-loop; other site 573370002788 ATP binding site [chemical binding]; other site 573370002789 Q-loop/lid; other site 573370002790 ABC transporter signature motif; other site 573370002791 Walker B; other site 573370002792 D-loop; other site 573370002793 H-loop/switch region; other site 573370002794 FOG: CBS domain [General function prediction only]; Region: COG0517 573370002795 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 573370002796 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 573370002797 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573370002798 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 573370002799 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 573370002800 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573370002801 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 573370002802 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 573370002803 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 573370002804 Bacterial SH3 domain homologues; Region: SH3b; smart00287 573370002805 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 573370002806 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 573370002807 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573370002808 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 573370002809 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 573370002810 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 573370002811 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573370002812 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 573370002813 CheB methylesterase; Region: CheB_methylest; pfam01339 573370002814 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 573370002815 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 573370002816 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 573370002817 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 573370002818 PAS domain; Region: PAS_10; pfam13596 573370002819 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370002820 putative active site [active] 573370002821 heme pocket [chemical binding]; other site 573370002822 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370002823 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370002824 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370002825 putative active site [active] 573370002826 heme pocket [chemical binding]; other site 573370002827 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370002828 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370002829 heme pocket [chemical binding]; other site 573370002830 putative active site [active] 573370002831 PAS domain; Region: PAS; smart00091 573370002832 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370002833 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370002834 putative active site [active] 573370002835 heme pocket [chemical binding]; other site 573370002836 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370002837 putative active site [active] 573370002838 heme pocket [chemical binding]; other site 573370002839 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370002840 dimer interface [polypeptide binding]; other site 573370002841 phosphorylation site [posttranslational modification] 573370002842 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370002843 ATP binding site [chemical binding]; other site 573370002844 Mg2+ binding site [ion binding]; other site 573370002845 G-X-G motif; other site 573370002846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370002847 active site 573370002848 phosphorylation site [posttranslational modification] 573370002849 intermolecular recognition site; other site 573370002850 dimerization interface [polypeptide binding]; other site 573370002851 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 573370002852 catalytic residues [active] 573370002853 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370002854 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370002855 active site 573370002856 phosphorylation site [posttranslational modification] 573370002857 intermolecular recognition site; other site 573370002858 dimerization interface [polypeptide binding]; other site 573370002859 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573370002860 DNA binding site [nucleotide binding] 573370002861 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 573370002862 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 573370002863 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 573370002864 Ligand Binding Site [chemical binding]; other site 573370002865 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 573370002866 GAF domain; Region: GAF_3; pfam13492 573370002867 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370002868 dimer interface [polypeptide binding]; other site 573370002869 phosphorylation site [posttranslational modification] 573370002870 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370002871 ATP binding site [chemical binding]; other site 573370002872 Mg2+ binding site [ion binding]; other site 573370002873 G-X-G motif; other site 573370002874 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 573370002875 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 573370002876 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 573370002877 Soluble P-type ATPase [General function prediction only]; Region: COG4087 573370002878 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 573370002879 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 573370002880 putative CheA interaction surface; other site 573370002881 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370002882 dimerization interface [polypeptide binding]; other site 573370002883 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370002884 PAS domain; Region: PAS_9; pfam13426 573370002885 putative active site [active] 573370002886 heme pocket [chemical binding]; other site 573370002887 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 573370002888 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370002889 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573370002890 dimer interface [polypeptide binding]; other site 573370002891 putative CheW interface [polypeptide binding]; other site 573370002892 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573370002893 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 573370002894 substrate binding pocket [chemical binding]; other site 573370002895 membrane-bound complex binding site; other site 573370002896 hinge residues; other site 573370002897 PAS domain S-box; Region: sensory_box; TIGR00229 573370002898 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370002899 putative active site [active] 573370002900 heme pocket [chemical binding]; other site 573370002901 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370002902 metal binding site [ion binding]; metal-binding site 573370002903 active site 573370002904 I-site; other site 573370002905 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 573370002906 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 573370002907 active site 573370002908 catalytic residues [active] 573370002909 DNA binding site [nucleotide binding] 573370002910 Int/Topo IB signature motif; other site 573370002911 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573370002912 active site 573370002913 DNA binding site [nucleotide binding] 573370002914 Int/Topo IB signature motif; other site 573370002915 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 573370002916 polymerase nucleotide-binding site; other site 573370002917 DNA-binding residues [nucleotide binding]; DNA binding site 573370002918 nucleotide binding site [chemical binding]; other site 573370002919 primase nucleotide-binding site [nucleotide binding]; other site 573370002920 AAA domain; Region: AAA_25; pfam13481 573370002921 Walker A motif; other site 573370002922 ATP binding site [chemical binding]; other site 573370002923 Walker B motif; other site 573370002924 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 573370002925 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370002926 Walker A motif; other site 573370002927 ATP binding site [chemical binding]; other site 573370002928 Walker B motif; other site 573370002929 arginine finger; other site 573370002930 PAS domain S-box; Region: sensory_box; TIGR00229 573370002931 PAS domain; Region: PAS; smart00091 573370002932 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 573370002933 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370002934 dimer interface [polypeptide binding]; other site 573370002935 phosphorylation site [posttranslational modification] 573370002936 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370002937 ATP binding site [chemical binding]; other site 573370002938 Mg2+ binding site [ion binding]; other site 573370002939 G-X-G motif; other site 573370002940 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370002941 active site 573370002942 phosphorylation site [posttranslational modification] 573370002943 intermolecular recognition site; other site 573370002944 dimerization interface [polypeptide binding]; other site 573370002945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370002946 active site 573370002947 phosphorylation site [posttranslational modification] 573370002948 intermolecular recognition site; other site 573370002949 dimerization interface [polypeptide binding]; other site 573370002950 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 573370002951 putative binding surface; other site 573370002952 active site 573370002953 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370002954 active site 573370002955 phosphorylation site [posttranslational modification] 573370002956 intermolecular recognition site; other site 573370002957 dimerization interface [polypeptide binding]; other site 573370002958 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370002959 active site 573370002960 phosphorylation site [posttranslational modification] 573370002961 intermolecular recognition site; other site 573370002962 dimerization interface [polypeptide binding]; other site 573370002963 Protein incorporated later into Tight Junctions; Region: Pilt; pfam15453 573370002964 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370002965 metal binding site [ion binding]; metal-binding site 573370002966 active site 573370002967 I-site; other site 573370002968 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 573370002969 Cache domain; Region: Cache_1; pfam02743 573370002970 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573370002971 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370002972 dimer interface [polypeptide binding]; other site 573370002973 phosphorylation site [posttranslational modification] 573370002974 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370002975 ATP binding site [chemical binding]; other site 573370002976 Mg2+ binding site [ion binding]; other site 573370002977 G-X-G motif; other site 573370002978 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370002979 dimerization interface [polypeptide binding]; other site 573370002980 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370002981 PAS domain; Region: PAS_9; pfam13426 573370002982 putative active site [active] 573370002983 heme pocket [chemical binding]; other site 573370002984 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 573370002985 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370002986 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573370002987 dimer interface [polypeptide binding]; other site 573370002988 putative CheW interface [polypeptide binding]; other site 573370002989 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370002990 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370002991 active site 573370002992 phosphorylation site [posttranslational modification] 573370002993 intermolecular recognition site; other site 573370002994 dimerization interface [polypeptide binding]; other site 573370002995 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573370002996 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 573370002997 substrate binding pocket [chemical binding]; other site 573370002998 membrane-bound complex binding site; other site 573370002999 hinge residues; other site 573370003000 PAS domain S-box; Region: sensory_box; TIGR00229 573370003001 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370003002 putative active site [active] 573370003003 heme pocket [chemical binding]; other site 573370003004 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370003005 metal binding site [ion binding]; metal-binding site 573370003006 active site 573370003007 I-site; other site 573370003008 PAS domain; Region: PAS_8; pfam13188 573370003009 PAS domain; Region: PAS_9; pfam13426 573370003010 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573370003011 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370003012 ATP binding site [chemical binding]; other site 573370003013 Mg2+ binding site [ion binding]; other site 573370003014 G-X-G motif; other site 573370003015 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 573370003016 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 573370003017 active site 573370003018 catalytic residues [active] 573370003019 DNA binding site [nucleotide binding] 573370003020 Int/Topo IB signature motif; other site 573370003021 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573370003022 active site 573370003023 DNA binding site [nucleotide binding] 573370003024 Int/Topo IB signature motif; other site 573370003025 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 573370003026 polymerase nucleotide-binding site; other site 573370003027 DNA-binding residues [nucleotide binding]; DNA binding site 573370003028 nucleotide binding site [chemical binding]; other site 573370003029 primase nucleotide-binding site [nucleotide binding]; other site 573370003030 RecA-family ATPase [DNA replication, recombination, and repair]; Region: RepA; COG3598 573370003031 AAA domain; Region: AAA_25; pfam13481 573370003032 Walker A motif; other site 573370003033 ATP binding site [chemical binding]; other site 573370003034 Walker B motif; other site 573370003035 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 573370003036 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370003037 Walker A motif; other site 573370003038 ATP binding site [chemical binding]; other site 573370003039 Walker B motif; other site 573370003040 arginine finger; other site 573370003041 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 573370003042 DNA binding residues [nucleotide binding] 573370003043 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 573370003044 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 573370003045 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370003046 putative active site [active] 573370003047 heme pocket [chemical binding]; other site 573370003048 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370003049 dimer interface [polypeptide binding]; other site 573370003050 phosphorylation site [posttranslational modification] 573370003051 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370003052 ATP binding site [chemical binding]; other site 573370003053 Mg2+ binding site [ion binding]; other site 573370003054 G-X-G motif; other site 573370003055 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370003056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370003057 active site 573370003058 phosphorylation site [posttranslational modification] 573370003059 intermolecular recognition site; other site 573370003060 dimerization interface [polypeptide binding]; other site 573370003061 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 573370003062 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370003063 active site 573370003064 phosphorylation site [posttranslational modification] 573370003065 intermolecular recognition site; other site 573370003066 dimerization interface [polypeptide binding]; other site 573370003067 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370003068 dimerization interface [polypeptide binding]; other site 573370003069 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370003070 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 573370003071 dimer interface [polypeptide binding]; other site 573370003072 putative CheW interface [polypeptide binding]; other site 573370003073 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 573370003074 putative CheA interaction surface; other site 573370003075 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 573370003076 putative CheA interaction surface; other site 573370003077 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370003078 dimerization interface [polypeptide binding]; other site 573370003079 PAS domain; Region: PAS_9; pfam13426 573370003080 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 573370003081 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370003082 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573370003083 dimer interface [polypeptide binding]; other site 573370003084 putative CheW interface [polypeptide binding]; other site 573370003085 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573370003086 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370003087 dimer interface [polypeptide binding]; other site 573370003088 phosphorylation site [posttranslational modification] 573370003089 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370003090 ATP binding site [chemical binding]; other site 573370003091 Mg2+ binding site [ion binding]; other site 573370003092 G-X-G motif; other site 573370003093 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370003094 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370003095 active site 573370003096 phosphorylation site [posttranslational modification] 573370003097 intermolecular recognition site; other site 573370003098 dimerization interface [polypeptide binding]; other site 573370003099 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370003100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370003101 active site 573370003102 phosphorylation site [posttranslational modification] 573370003103 intermolecular recognition site; other site 573370003104 dimerization interface [polypeptide binding]; other site 573370003105 PAS domain; Region: PAS_8; pfam13188 573370003106 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 573370003107 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370003108 ATP binding site [chemical binding]; other site 573370003109 Mg2+ binding site [ion binding]; other site 573370003110 G-X-G motif; other site 573370003111 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 573370003112 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 573370003113 active site 573370003114 catalytic residues [active] 573370003115 DNA binding site [nucleotide binding] 573370003116 Int/Topo IB signature motif; other site 573370003117 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573370003118 active site 573370003119 DNA binding site [nucleotide binding] 573370003120 Int/Topo IB signature motif; other site 573370003121 EspA-like secreted protein; Region: EspA; cl04069 573370003122 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 573370003123 polymerase nucleotide-binding site; other site 573370003124 DNA-binding residues [nucleotide binding]; DNA binding site 573370003125 nucleotide binding site [chemical binding]; other site 573370003126 primase nucleotide-binding site [nucleotide binding]; other site 573370003127 AAA domain; Region: AAA_25; pfam13481 573370003128 Walker A motif; other site 573370003129 ATP binding site [chemical binding]; other site 573370003130 Walker B motif; other site 573370003131 YcgL domain; Region: YcgL; cl01189 573370003132 flagellin; Provisional; Region: PRK12806 573370003133 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 573370003134 Cortical protein marker for cell polarity; Region: Rax2; pfam12768 573370003135 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 573370003136 flagellin; Provisional; Region: PRK12806 573370003137 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 573370003138 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 573370003139 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573370003140 non-specific DNA binding site [nucleotide binding]; other site 573370003141 salt bridge; other site 573370003142 sequence-specific DNA binding site [nucleotide binding]; other site 573370003143 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 573370003144 legume lectins; Region: lectin_L-type; cl14058 573370003145 carbohydrate binding site [chemical binding]; other site 573370003146 metal binding site [ion binding]; metal-binding site 573370003147 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 573370003148 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 573370003149 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370003150 active site 573370003151 phosphorylation site [posttranslational modification] 573370003152 intermolecular recognition site; other site 573370003153 dimerization interface [polypeptide binding]; other site 573370003154 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 573370003155 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 573370003156 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370003157 PAS domain; Region: PAS_9; pfam13426 573370003158 putative active site [active] 573370003159 heme pocket [chemical binding]; other site 573370003160 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370003161 metal binding site [ion binding]; metal-binding site 573370003162 active site 573370003163 I-site; other site 573370003164 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370003165 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370003166 active site 573370003167 phosphorylation site [posttranslational modification] 573370003168 intermolecular recognition site; other site 573370003169 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370003170 active site 573370003171 phosphorylation site [posttranslational modification] 573370003172 intermolecular recognition site; other site 573370003173 dimerization interface [polypeptide binding]; other site 573370003174 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370003175 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370003176 active site 573370003177 phosphorylation site [posttranslational modification] 573370003178 intermolecular recognition site; other site 573370003179 dimerization interface [polypeptide binding]; other site 573370003180 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370003181 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370003182 putative active site [active] 573370003183 heme pocket [chemical binding]; other site 573370003184 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 573370003185 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370003186 putative active site [active] 573370003187 heme pocket [chemical binding]; other site 573370003188 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370003189 dimer interface [polypeptide binding]; other site 573370003190 phosphorylation site [posttranslational modification] 573370003191 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370003192 ATP binding site [chemical binding]; other site 573370003193 Mg2+ binding site [ion binding]; other site 573370003194 G-X-G motif; other site 573370003195 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370003196 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370003197 active site 573370003198 phosphorylation site [posttranslational modification] 573370003199 intermolecular recognition site; other site 573370003200 dimerization interface [polypeptide binding]; other site 573370003201 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 573370003202 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370003203 active site 573370003204 phosphorylation site [posttranslational modification] 573370003205 intermolecular recognition site; other site 573370003206 dimerization interface [polypeptide binding]; other site 573370003207 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370003208 dimerization interface [polypeptide binding]; other site 573370003209 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 573370003210 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370003211 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 573370003212 dimer interface [polypeptide binding]; other site 573370003213 putative CheW interface [polypeptide binding]; other site 573370003214 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 573370003215 putative CheA interaction surface; other site 573370003216 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370003217 dimerization interface [polypeptide binding]; other site 573370003218 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370003219 PAS domain; Region: PAS_9; pfam13426 573370003220 putative active site [active] 573370003221 heme pocket [chemical binding]; other site 573370003222 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 573370003223 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370003224 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573370003225 dimer interface [polypeptide binding]; other site 573370003226 putative CheW interface [polypeptide binding]; other site 573370003227 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 573370003228 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 573370003229 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 573370003230 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 573370003231 active site 573370003232 dimer interface [polypeptide binding]; other site 573370003233 motif 1; other site 573370003234 motif 2; other site 573370003235 motif 3; other site 573370003236 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 573370003237 anticodon binding site; other site 573370003238 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 573370003239 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 573370003240 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 573370003241 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 573370003242 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 573370003243 23S rRNA binding site [nucleotide binding]; other site 573370003244 L21 binding site [polypeptide binding]; other site 573370003245 L13 binding site [polypeptide binding]; other site 573370003246 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 573370003247 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 573370003248 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 573370003249 dimer interface [polypeptide binding]; other site 573370003250 motif 1; other site 573370003251 active site 573370003252 motif 2; other site 573370003253 motif 3; other site 573370003254 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 573370003255 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 573370003256 putative tRNA-binding site [nucleotide binding]; other site 573370003257 B3/4 domain; Region: B3_4; pfam03483 573370003258 tRNA synthetase B5 domain; Region: B5; smart00874 573370003259 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 573370003260 dimer interface [polypeptide binding]; other site 573370003261 motif 1; other site 573370003262 motif 3; other site 573370003263 motif 2; other site 573370003264 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 573370003265 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 573370003266 Heavy-metal resistance; Region: Metal_resist; pfam13801 573370003267 RNA polymerase sigma factor; Reviewed; Region: PRK05602 573370003268 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573370003269 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573370003270 DNA binding residues [nucleotide binding] 573370003271 Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839 573370003272 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 573370003273 dimer interface [polypeptide binding]; other site 573370003274 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 573370003275 Putative lysophospholipase; Region: Hydrolase_4; cl19140 573370003276 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 573370003277 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 573370003278 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 573370003279 DNA binding residues [nucleotide binding] 573370003280 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 573370003281 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 573370003282 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 573370003283 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 573370003284 HAMP domain; Region: HAMP; pfam00672 573370003285 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370003286 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 573370003287 dimer interface [polypeptide binding]; other site 573370003288 putative CheW interface [polypeptide binding]; other site 573370003289 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 573370003290 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 573370003291 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573370003292 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 573370003293 FtsX-like permease family; Region: FtsX; pfam02687 573370003294 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 573370003295 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573370003296 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370003297 dimerization interface [polypeptide binding]; other site 573370003298 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370003299 dimer interface [polypeptide binding]; other site 573370003300 phosphorylation site [posttranslational modification] 573370003301 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370003302 ATP binding site [chemical binding]; other site 573370003303 Mg2+ binding site [ion binding]; other site 573370003304 G-X-G motif; other site 573370003305 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 573370003306 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370003307 active site 573370003308 phosphorylation site [posttranslational modification] 573370003309 intermolecular recognition site; other site 573370003310 dimerization interface [polypeptide binding]; other site 573370003311 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370003312 Walker A motif; other site 573370003313 ATP binding site [chemical binding]; other site 573370003314 Walker B motif; other site 573370003315 arginine finger; other site 573370003316 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 573370003317 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370003318 active site 573370003319 phosphorylation site [posttranslational modification] 573370003320 intermolecular recognition site; other site 573370003321 dimerization interface [polypeptide binding]; other site 573370003322 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370003323 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 573370003324 Walker A motif; other site 573370003325 ATP binding site [chemical binding]; other site 573370003326 Walker B motif; other site 573370003327 arginine finger; other site 573370003328 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 573370003329 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 573370003330 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 573370003331 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370003332 metal binding site [ion binding]; metal-binding site 573370003333 active site 573370003334 I-site; other site 573370003335 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 573370003336 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 573370003337 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 573370003338 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 573370003339 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 573370003340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370003341 active site 573370003342 phosphorylation site [posttranslational modification] 573370003343 intermolecular recognition site; other site 573370003344 dimerization interface [polypeptide binding]; other site 573370003345 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 573370003346 Histidine kinase; Region: HisKA_2; pfam07568 573370003347 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370003348 ATP binding site [chemical binding]; other site 573370003349 Mg2+ binding site [ion binding]; other site 573370003350 G-X-G motif; other site 573370003351 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370003352 active site 573370003353 phosphorylation site [posttranslational modification] 573370003354 intermolecular recognition site; other site 573370003355 dimerization interface [polypeptide binding]; other site 573370003356 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370003357 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573370003358 putative active site [active] 573370003359 heme pocket [chemical binding]; other site 573370003360 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370003361 dimer interface [polypeptide binding]; other site 573370003362 phosphorylation site [posttranslational modification] 573370003363 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370003364 ATP binding site [chemical binding]; other site 573370003365 Mg2+ binding site [ion binding]; other site 573370003366 G-X-G motif; other site 573370003367 Predicted membrane protein [Function unknown]; Region: COG2119 573370003368 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 573370003369 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 573370003370 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 573370003371 dimer interface [polypeptide binding]; other site 573370003372 putative functional site; other site 573370003373 putative MPT binding site; other site 573370003374 PBP superfamily domain; Region: PBP_like; pfam12727 573370003375 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 573370003376 putative active site; other site 573370003377 catalytic triad [active] 573370003378 putative dimer interface [polypeptide binding]; other site 573370003379 LysE type translocator; Region: LysE; cl00565 573370003380 Glucokinase; Region: Glucokinase; cl17310 573370003381 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 573370003382 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 573370003383 dimer interface [polypeptide binding]; other site 573370003384 putative functional site; other site 573370003385 putative MPT binding site; other site 573370003386 Putative rhamnosyl transferase; Region: Rhamno_transf; pfam11316 573370003387 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 573370003388 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 573370003389 CheB methylesterase; Region: CheB_methylest; pfam01339 573370003390 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 573370003391 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 573370003392 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 573370003393 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 573370003394 PAS domain; Region: PAS_10; pfam13596 573370003395 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370003396 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370003397 putative active site [active] 573370003398 heme pocket [chemical binding]; other site 573370003399 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370003400 putative active site [active] 573370003401 heme pocket [chemical binding]; other site 573370003402 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370003403 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370003404 putative active site [active] 573370003405 heme pocket [chemical binding]; other site 573370003406 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370003407 dimer interface [polypeptide binding]; other site 573370003408 phosphorylation site [posttranslational modification] 573370003409 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370003410 ATP binding site [chemical binding]; other site 573370003411 Mg2+ binding site [ion binding]; other site 573370003412 G-X-G motif; other site 573370003413 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370003414 active site 573370003415 phosphorylation site [posttranslational modification] 573370003416 intermolecular recognition site; other site 573370003417 dimerization interface [polypeptide binding]; other site 573370003418 Tim44-like domain; Region: Tim44; pfam04280 573370003419 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 573370003420 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370003421 putative active site [active] 573370003422 heme pocket [chemical binding]; other site 573370003423 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370003424 dimer interface [polypeptide binding]; other site 573370003425 phosphorylation site [posttranslational modification] 573370003426 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370003427 ATP binding site [chemical binding]; other site 573370003428 Mg2+ binding site [ion binding]; other site 573370003429 G-X-G motif; other site 573370003430 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 573370003431 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 573370003432 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370003433 ATP binding site [chemical binding]; other site 573370003434 Mg2+ binding site [ion binding]; other site 573370003435 G-X-G motif; other site 573370003436 Transposase; Region: DEDD_Tnp_IS110; pfam01548 573370003437 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 573370003438 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 573370003439 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 573370003440 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573370003441 active site 573370003442 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 573370003443 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 573370003444 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 573370003445 nucleotidyl binding site; other site 573370003446 metal binding site [ion binding]; metal-binding site 573370003447 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370003448 TPR motif; other site 573370003449 binding surface 573370003450 TPR repeat; Region: TPR_11; pfam13414 573370003451 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573370003452 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370003453 binding surface 573370003454 TPR motif; other site 573370003455 TPR repeat; Region: TPR_11; pfam13414 573370003456 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 573370003457 Zinc ribbon domain; Region: Zn-ribbon_8; cl00993 573370003458 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078 573370003459 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 573370003460 Dinitrogenase iron-molybdenum cofactor; Region: Nitro_FeMo-Co; pfam02579 573370003461 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 573370003462 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 573370003463 P loop nucleotide binding; other site 573370003464 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 573370003465 switch II; other site 573370003466 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 573370003467 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 573370003468 P loop nucleotide binding; other site 573370003469 switch II; other site 573370003470 Dinitrogenase iron-molybdenum cofactor; Region: Nitro_FeMo-Co; pfam02579 573370003471 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 573370003472 active site 573370003473 trimerization site [polypeptide binding]; other site 573370003474 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 573370003475 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 573370003476 Walker A motif; other site 573370003477 LabA_like proteins; Region: LabA_like; cd06167 573370003478 putative metal binding site [ion binding]; other site 573370003479 Uncharacterized conserved protein [Function unknown]; Region: COG1432 573370003480 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cd00596 573370003481 active site 573370003482 Zn binding site [ion binding]; other site 573370003483 Uncharacterized conserved protein [Function unknown]; Region: COG5361 573370003484 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 573370003485 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 573370003486 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 573370003487 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 573370003488 acyl-activating enzyme (AAE) consensus motif; other site 573370003489 AMP binding site [chemical binding]; other site 573370003490 active site 573370003491 CoA binding site [chemical binding]; other site 573370003492 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 573370003493 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 573370003494 Walker A/P-loop; other site 573370003495 ATP binding site [chemical binding]; other site 573370003496 Q-loop/lid; other site 573370003497 ABC transporter signature motif; other site 573370003498 Walker B; other site 573370003499 D-loop; other site 573370003500 H-loop/switch region; other site 573370003501 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 573370003502 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 573370003503 Walker A/P-loop; other site 573370003504 ATP binding site [chemical binding]; other site 573370003505 Q-loop/lid; other site 573370003506 ABC transporter signature motif; other site 573370003507 Walker B; other site 573370003508 D-loop; other site 573370003509 H-loop/switch region; other site 573370003510 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 573370003511 TM-ABC transporter signature motif; other site 573370003512 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 573370003513 TM-ABC transporter signature motif; other site 573370003514 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 573370003515 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 573370003516 putative ligand binding site [chemical binding]; other site 573370003517 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 573370003518 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 573370003519 putative ligand binding site [chemical binding]; other site 573370003520 zinc transporter ZupT; Provisional; Region: PRK04201 573370003521 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 573370003522 heat shock protein 90; Provisional; Region: PRK05218 573370003523 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370003524 ATP binding site [chemical binding]; other site 573370003525 Mg2+ binding site [ion binding]; other site 573370003526 G-X-G motif; other site 573370003527 Hsp90 protein; Region: HSP90; pfam00183 573370003528 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 573370003529 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 573370003530 putative dimer interface [polypeptide binding]; other site 573370003531 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 573370003532 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 573370003533 putative dimer interface [polypeptide binding]; other site 573370003534 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; cl19880 573370003535 histone-like DNA-binding protein HU; Region: HU; cd13831 573370003536 dimer interface [polypeptide binding]; other site 573370003537 DNA binding site [nucleotide binding] 573370003538 FOG: CBS domain [General function prediction only]; Region: COG0517 573370003539 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 573370003540 Cupin domain; Region: Cupin_2; pfam07883 573370003541 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 573370003542 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573370003543 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573370003544 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573370003545 Mechanosensitive ion channel; Region: MS_channel; pfam00924 573370003546 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 573370003547 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 573370003548 ligand binding site [chemical binding]; other site 573370003549 flexible hinge region; other site 573370003550 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 573370003551 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 573370003552 active site 573370003553 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370003554 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370003555 active site 573370003556 phosphorylation site [posttranslational modification] 573370003557 intermolecular recognition site; other site 573370003558 dimerization interface [polypeptide binding]; other site 573370003559 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370003560 active site 573370003561 phosphorylation site [posttranslational modification] 573370003562 intermolecular recognition site; other site 573370003563 dimerization interface [polypeptide binding]; other site 573370003564 Hpt domain; Region: Hpt; pfam01627 573370003565 putative binding surface; other site 573370003566 active site 573370003567 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 573370003568 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 573370003569 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 573370003570 active site 573370003571 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 573370003572 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 573370003573 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 573370003574 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 573370003575 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370003576 binding surface 573370003577 Tetratricopeptide repeat; Region: TPR_16; pfam13432 573370003578 TPR motif; other site 573370003579 TPR repeat; Region: TPR_11; pfam13414 573370003580 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370003581 TPR motif; other site 573370003582 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 573370003583 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 573370003584 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 573370003585 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 573370003586 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 573370003587 active site 573370003588 substrate binding site [chemical binding]; other site 573370003589 ATP binding site [chemical binding]; other site 573370003590 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14184 573370003591 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 573370003592 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 573370003593 homodimer interface [polypeptide binding]; other site 573370003594 NADP binding site [chemical binding]; other site 573370003595 substrate binding site [chemical binding]; other site 573370003596 enolase; Provisional; Region: eno; PRK00077 573370003597 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 573370003598 dimer interface [polypeptide binding]; other site 573370003599 metal binding site [ion binding]; metal-binding site 573370003600 substrate binding pocket [chemical binding]; other site 573370003601 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370003602 TPR motif; other site 573370003603 Tetratricopeptide repeat; Region: TPR_19; pfam14559 573370003604 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 573370003605 nucleotide binding site [chemical binding]; other site 573370003606 Type III pantothenate kinase; Region: Pan_kinase; cl17198 573370003607 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 573370003608 active site 573370003609 catalytic triad [active] 573370003610 oxyanion hole [active] 573370003611 switch loop; other site 573370003612 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 573370003613 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 573370003614 Walker A/P-loop; other site 573370003615 ATP binding site [chemical binding]; other site 573370003616 Q-loop/lid; other site 573370003617 ABC transporter signature motif; other site 573370003618 Walker B; other site 573370003619 D-loop; other site 573370003620 H-loop/switch region; other site 573370003621 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 573370003622 RNA/DNA hybrid binding site [nucleotide binding]; other site 573370003623 active site 573370003624 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 573370003625 PemK-like protein; Region: PemK; cl00995 573370003626 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 573370003627 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 573370003628 putative FMN binding site [chemical binding]; other site 573370003629 NADPH bind site [chemical binding]; other site 573370003630 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573370003631 Zn2+ binding site [ion binding]; other site 573370003632 Mg2+ binding site [ion binding]; other site 573370003633 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 573370003634 CoA binding domain; Region: CoA_binding_2; pfam13380 573370003635 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 573370003636 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 573370003637 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 573370003638 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 573370003639 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 573370003640 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 573370003641 substrate binding site [chemical binding]; other site 573370003642 oxyanion hole (OAH) forming residues; other site 573370003643 trimer interface [polypeptide binding]; other site 573370003644 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573370003645 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370003646 dimer interface [polypeptide binding]; other site 573370003647 phosphorylation site [posttranslational modification] 573370003648 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370003649 ATP binding site [chemical binding]; other site 573370003650 Mg2+ binding site [ion binding]; other site 573370003651 G-X-G motif; other site 573370003652 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 573370003653 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 573370003654 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 573370003655 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 573370003656 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 573370003657 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 573370003658 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 573370003659 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 573370003660 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 573370003661 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573370003662 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 573370003663 catalytic triad [active] 573370003664 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 573370003665 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 573370003666 active site 573370003667 SAM binding site [chemical binding]; other site 573370003668 homodimer interface [polypeptide binding]; other site 573370003669 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 573370003670 active site 573370003671 putative homodimer interface [polypeptide binding]; other site 573370003672 SAM binding site [chemical binding]; other site 573370003673 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370003674 S-adenosylmethionine binding site [chemical binding]; other site 573370003675 Transposase; Region: DEDD_Tnp_IS110; pfam01548 573370003676 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 573370003677 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 573370003678 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 573370003679 Uncharacterized conserved protein [Function unknown]; Region: COG3937 573370003680 Predicted membrane protein [Function unknown]; Region: COG4803 573370003681 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 573370003682 active site 573370003683 FMN binding site [chemical binding]; other site 573370003684 substrate binding site [chemical binding]; other site 573370003685 putative catalytic residue [active] 573370003686 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 573370003687 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 573370003688 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 573370003689 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 573370003690 FeoA domain; Region: FeoA; pfam04023 573370003691 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 573370003692 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 573370003693 G1 box; other site 573370003694 GTP/Mg2+ binding site [chemical binding]; other site 573370003695 Switch I region; other site 573370003696 G2 box; other site 573370003697 G3 box; other site 573370003698 Switch II region; other site 573370003699 G4 box; other site 573370003700 G5 box; other site 573370003701 Nucleoside recognition; Region: Gate; pfam07670 573370003702 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 573370003703 Nucleoside recognition; Region: Gate; pfam07670 573370003704 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 573370003705 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 573370003706 Walker A/P-loop; other site 573370003707 ATP binding site [chemical binding]; other site 573370003708 Q-loop/lid; other site 573370003709 ABC transporter signature motif; other site 573370003710 Walker B; other site 573370003711 D-loop; other site 573370003712 H-loop/switch region; other site 573370003713 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 573370003714 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 573370003715 Walker A/P-loop; other site 573370003716 ATP binding site [chemical binding]; other site 573370003717 Q-loop/lid; other site 573370003718 ABC transporter signature motif; other site 573370003719 Walker B; other site 573370003720 D-loop; other site 573370003721 H-loop/switch region; other site 573370003722 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 573370003723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573370003724 dimer interface [polypeptide binding]; other site 573370003725 conserved gate region; other site 573370003726 putative PBP binding loops; other site 573370003727 ABC-ATPase subunit interface; other site 573370003728 nickel transporter permease NikB; Provisional; Region: PRK10352 573370003729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573370003730 dimer interface [polypeptide binding]; other site 573370003731 conserved gate region; other site 573370003732 putative PBP binding loops; other site 573370003733 ABC-ATPase subunit interface; other site 573370003734 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 573370003735 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 573370003736 substrate binding site [chemical binding]; other site 573370003737 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 573370003738 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 573370003739 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 573370003740 putative active site [active] 573370003741 putative substrate binding site [chemical binding]; other site 573370003742 putative cosubstrate binding site; other site 573370003743 catalytic site [active] 573370003744 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 573370003745 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 573370003746 putative ligand binding site [chemical binding]; other site 573370003747 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 573370003748 TM-ABC transporter signature motif; other site 573370003749 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 573370003750 TM-ABC transporter signature motif; other site 573370003751 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 573370003752 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 573370003753 Walker A/P-loop; other site 573370003754 ATP binding site [chemical binding]; other site 573370003755 Q-loop/lid; other site 573370003756 ABC transporter signature motif; other site 573370003757 Walker B; other site 573370003758 D-loop; other site 573370003759 H-loop/switch region; other site 573370003760 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 573370003761 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 573370003762 Walker A/P-loop; other site 573370003763 ATP binding site [chemical binding]; other site 573370003764 Q-loop/lid; other site 573370003765 ABC transporter signature motif; other site 573370003766 Walker B; other site 573370003767 D-loop; other site 573370003768 H-loop/switch region; other site 573370003769 Integral membrane diacylglycerol kinase and similar enzymes; Region: DAGK_IM_like; cd14263 573370003770 trimer interface [polypeptide binding]; other site 573370003771 putative active site [active] 573370003772 Zn binding site [ion binding]; other site 573370003773 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 573370003774 S17 interaction site [polypeptide binding]; other site 573370003775 S8 interaction site; other site 573370003776 16S rRNA interaction site [nucleotide binding]; other site 573370003777 streptomycin interaction site [chemical binding]; other site 573370003778 23S rRNA interaction site [nucleotide binding]; other site 573370003779 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 573370003780 30S ribosomal protein S7; Validated; Region: PRK05302 573370003781 elongation factor G; Reviewed; Region: PRK00007 573370003782 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 573370003783 G1 box; other site 573370003784 putative GEF interaction site [polypeptide binding]; other site 573370003785 GTP/Mg2+ binding site [chemical binding]; other site 573370003786 Switch I region; other site 573370003787 G2 box; other site 573370003788 G3 box; other site 573370003789 Switch II region; other site 573370003790 G4 box; other site 573370003791 G5 box; other site 573370003792 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 573370003793 Elongation Factor G, domain II; Region: EFG_II; pfam14492 573370003794 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 573370003795 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 573370003796 elongation factor Tu; Reviewed; Region: PRK00049 573370003797 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 573370003798 G1 box; other site 573370003799 GEF interaction site [polypeptide binding]; other site 573370003800 GTP/Mg2+ binding site [chemical binding]; other site 573370003801 Switch I region; other site 573370003802 G2 box; other site 573370003803 G3 box; other site 573370003804 Switch II region; other site 573370003805 G4 box; other site 573370003806 G5 box; other site 573370003807 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 573370003808 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 573370003809 Antibiotic Binding Site [chemical binding]; other site 573370003810 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 573370003811 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 573370003812 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 573370003813 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 573370003814 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 573370003815 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 573370003816 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 573370003817 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 573370003818 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 573370003819 putative translocon binding site; other site 573370003820 protein-rRNA interface [nucleotide binding]; other site 573370003821 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 573370003822 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 573370003823 G-X-X-G motif; other site 573370003824 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 573370003825 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 573370003826 23S rRNA interface [nucleotide binding]; other site 573370003827 5S rRNA interface [nucleotide binding]; other site 573370003828 putative antibiotic binding site [chemical binding]; other site 573370003829 L25 interface [polypeptide binding]; other site 573370003830 L27 interface [polypeptide binding]; other site 573370003831 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 573370003832 23S rRNA interface [nucleotide binding]; other site 573370003833 putative translocon interaction site; other site 573370003834 signal recognition particle (SRP54) interaction site; other site 573370003835 L23 interface [polypeptide binding]; other site 573370003836 trigger factor interaction site; other site 573370003837 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 573370003838 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 573370003839 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 573370003840 RNA binding site [nucleotide binding]; other site 573370003841 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 573370003842 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 573370003843 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 573370003844 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 573370003845 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 573370003846 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 573370003847 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 573370003848 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 573370003849 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 573370003850 23S rRNA interface [nucleotide binding]; other site 573370003851 L21e interface [polypeptide binding]; other site 573370003852 5S rRNA interface [nucleotide binding]; other site 573370003853 L27 interface [polypeptide binding]; other site 573370003854 L5 interface [polypeptide binding]; other site 573370003855 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 573370003856 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 573370003857 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 573370003858 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 573370003859 23S rRNA binding site [nucleotide binding]; other site 573370003860 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 573370003861 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 573370003862 SecY translocase; Region: SecY; pfam00344 573370003863 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 573370003864 active site 573370003865 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 573370003866 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 573370003867 30S ribosomal protein S11; Validated; Region: PRK05309 573370003868 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 573370003869 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 573370003870 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 573370003871 RNA binding surface [nucleotide binding]; other site 573370003872 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 573370003873 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 573370003874 alphaNTD - beta interaction site [polypeptide binding]; other site 573370003875 alphaNTD homodimer interface [polypeptide binding]; other site 573370003876 alphaNTD - beta' interaction site [polypeptide binding]; other site 573370003877 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 573370003878 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 573370003879 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573370003880 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573370003881 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 573370003882 putative dimerization interface [polypeptide binding]; other site 573370003883 Sulfotransferase family; Region: Sulfotransfer_2; cl19526 573370003884 flagellin; Reviewed; Region: PRK08869 573370003885 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 573370003886 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 573370003887 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 573370003888 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573370003889 dimer interface [polypeptide binding]; other site 573370003890 conserved gate region; other site 573370003891 putative PBP binding loops; other site 573370003892 ABC-ATPase subunit interface; other site 573370003893 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 573370003894 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 573370003895 Walker A/P-loop; other site 573370003896 ATP binding site [chemical binding]; other site 573370003897 Q-loop/lid; other site 573370003898 ABC transporter signature motif; other site 573370003899 Walker B; other site 573370003900 D-loop; other site 573370003901 H-loop/switch region; other site 573370003902 putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/FeS domain-containing protein protein; Provisional; Region: PRK14494 573370003903 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573370003904 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573370003905 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370003906 ATP binding site [chemical binding]; other site 573370003907 Mg2+ binding site [ion binding]; other site 573370003908 G-X-G motif; other site 573370003909 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 573370003910 Predicted transcriptional regulators [Transcription]; Region: COG1378 573370003911 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 573370003912 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 573370003913 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573370003914 Coenzyme A binding pocket [chemical binding]; other site 573370003915 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 573370003916 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370003917 dimerization interface [polypeptide binding]; other site 573370003918 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 573370003919 dimer interface [polypeptide binding]; other site 573370003920 putative CheW interface [polypeptide binding]; other site 573370003921 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370003922 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573370003923 dimer interface [polypeptide binding]; other site 573370003924 putative CheW interface [polypeptide binding]; other site 573370003925 HPP family; Region: HPP; pfam04982 573370003926 FOG: CBS domain [General function prediction only]; Region: COG0517 573370003927 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 573370003928 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 573370003929 Uncharacterized BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 573370003930 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 573370003931 purine nucleoside phosphorylase; Provisional; Region: PRK08202 573370003932 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 573370003933 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 573370003934 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 573370003935 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 573370003936 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 573370003937 ligand binding site [chemical binding]; other site 573370003938 PilZ domain; Region: PilZ; pfam07238 573370003939 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 573370003940 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 573370003941 ATP-grasp domain; Region: ATP-grasp_4; cl17255 573370003942 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 573370003943 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 573370003944 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 573370003945 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 573370003946 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 573370003947 dimer interface [polypeptide binding]; other site 573370003948 ssDNA binding site [nucleotide binding]; other site 573370003949 tetramer (dimer of dimers) interface [polypeptide binding]; other site 573370003950 Heavy-metal-associated domain; Region: HMA; pfam00403 573370003951 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 573370003952 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 573370003953 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 573370003954 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 573370003955 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 573370003956 DNA binding residues [nucleotide binding] 573370003957 dimer interface [polypeptide binding]; other site 573370003958 putative metal binding site [ion binding]; other site 573370003959 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 573370003960 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370003961 active site 573370003962 phosphorylation site [posttranslational modification] 573370003963 intermolecular recognition site; other site 573370003964 dimerization interface [polypeptide binding]; other site 573370003965 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370003966 active site 573370003967 phosphorylation site [posttranslational modification] 573370003968 intermolecular recognition site; other site 573370003969 dimerization interface [polypeptide binding]; other site 573370003970 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370003971 dimerization interface [polypeptide binding]; other site 573370003972 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370003973 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 573370003974 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370003975 putative active site [active] 573370003976 heme pocket [chemical binding]; other site 573370003977 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370003978 dimer interface [polypeptide binding]; other site 573370003979 phosphorylation site [posttranslational modification] 573370003980 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370003981 ATP binding site [chemical binding]; other site 573370003982 Mg2+ binding site [ion binding]; other site 573370003983 G-X-G motif; other site 573370003984 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 573370003985 active site 573370003986 Int/Topo IB signature motif; other site 573370003987 catalytic residues [active] 573370003988 DNA binding site [nucleotide binding] 573370003989 TOBE domain; Region: TOBE; cl01440 573370003990 TOBE domain; Region: TOBE; cl01440 573370003991 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 573370003992 heme-binding residues [chemical binding]; other site 573370003993 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 573370003994 heme-binding residues [chemical binding]; other site 573370003995 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 573370003996 heme-binding residues [chemical binding]; other site 573370003997 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 573370003998 heme-binding residues [chemical binding]; other site 573370003999 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 573370004000 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 573370004001 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 573370004002 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 573370004003 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 573370004004 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 573370004005 Ligand Binding Site [chemical binding]; other site 573370004006 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 573370004007 Ligand Binding Site [chemical binding]; other site 573370004008 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370004009 active site 573370004010 phosphorylation site [posttranslational modification] 573370004011 intermolecular recognition site; other site 573370004012 dimerization interface [polypeptide binding]; other site 573370004013 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 573370004014 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370004015 active site 573370004016 phosphorylation site [posttranslational modification] 573370004017 intermolecular recognition site; other site 573370004018 dimerization interface [polypeptide binding]; other site 573370004019 PAS fold; Region: PAS_4; pfam08448 573370004020 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370004021 putative active site [active] 573370004022 heme pocket [chemical binding]; other site 573370004023 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 573370004024 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370004025 ATP binding site [chemical binding]; other site 573370004026 Mg2+ binding site [ion binding]; other site 573370004027 G-X-G motif; other site 573370004028 TIGR03943 family protein; Region: TIGR03943 573370004029 Predicted permeases [General function prediction only]; Region: COG0701 573370004030 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 573370004031 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 573370004032 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 573370004033 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 573370004034 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 573370004035 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 573370004036 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 573370004037 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 573370004038 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 573370004039 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 573370004040 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573370004041 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 573370004042 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 573370004043 active site residue [active] 573370004044 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 573370004045 putative SAM binding site [chemical binding]; other site 573370004046 putative homodimer interface [polypeptide binding]; other site 573370004047 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 573370004048 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370004049 dimer interface [polypeptide binding]; other site 573370004050 phosphorylation site [posttranslational modification] 573370004051 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370004052 ATP binding site [chemical binding]; other site 573370004053 Mg2+ binding site [ion binding]; other site 573370004054 G-X-G motif; other site 573370004055 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 573370004056 putative binding surface; other site 573370004057 active site 573370004058 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370004059 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370004060 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 573370004061 putative active site [active] 573370004062 heme pocket [chemical binding]; other site 573370004063 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370004064 ATP binding site [chemical binding]; other site 573370004065 Mg2+ binding site [ion binding]; other site 573370004066 G-X-G motif; other site 573370004067 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 573370004068 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370004069 active site 573370004070 phosphorylation site [posttranslational modification] 573370004071 intermolecular recognition site; other site 573370004072 dimerization interface [polypeptide binding]; other site 573370004073 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370004074 Walker A motif; other site 573370004075 ATP binding site [chemical binding]; other site 573370004076 Walker B motif; other site 573370004077 arginine finger; other site 573370004078 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 573370004079 Late competence development protein ComFB; Region: ComFB; pfam10719 573370004080 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 573370004081 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 573370004082 NAD binding site [chemical binding]; other site 573370004083 homodimer interface [polypeptide binding]; other site 573370004084 active site 573370004085 substrate binding site [chemical binding]; other site 573370004086 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573370004087 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573370004088 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573370004089 Walker A/P-loop; other site 573370004090 ATP binding site [chemical binding]; other site 573370004091 Q-loop/lid; other site 573370004092 ABC transporter signature motif; other site 573370004093 Walker B; other site 573370004094 D-loop; other site 573370004095 H-loop/switch region; other site 573370004096 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 573370004097 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 573370004098 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 573370004099 active site 573370004100 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 573370004101 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 573370004102 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370004103 dimerization interface [polypeptide binding]; other site 573370004104 PAS fold; Region: PAS_4; pfam08448 573370004105 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 573370004106 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370004107 putative active site [active] 573370004108 heme pocket [chemical binding]; other site 573370004109 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370004110 dimer interface [polypeptide binding]; other site 573370004111 phosphorylation site [posttranslational modification] 573370004112 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370004113 ATP binding site [chemical binding]; other site 573370004114 Mg2+ binding site [ion binding]; other site 573370004115 G-X-G motif; other site 573370004116 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370004117 active site 573370004118 phosphorylation site [posttranslational modification] 573370004119 intermolecular recognition site; other site 573370004120 dimerization interface [polypeptide binding]; other site 573370004121 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370004122 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370004123 putative active site [active] 573370004124 heme pocket [chemical binding]; other site 573370004125 PAS domain; Region: PAS_8; pfam13188 573370004126 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 573370004127 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370004128 ATP binding site [chemical binding]; other site 573370004129 Mg2+ binding site [ion binding]; other site 573370004130 G-X-G motif; other site 573370004131 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370004132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370004133 active site 573370004134 phosphorylation site [posttranslational modification] 573370004135 intermolecular recognition site; other site 573370004136 Protein of unknown function (DUF1641); Region: DUF1641; pfam07849 573370004137 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 573370004138 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370004139 active site 573370004140 phosphorylation site [posttranslational modification] 573370004141 intermolecular recognition site; other site 573370004142 dimerization interface [polypeptide binding]; other site 573370004143 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370004144 dimer interface [polypeptide binding]; other site 573370004145 phosphorylation site [posttranslational modification] 573370004146 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370004147 ATP binding site [chemical binding]; other site 573370004148 Mg2+ binding site [ion binding]; other site 573370004149 G-X-G motif; other site 573370004150 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370004151 active site 573370004152 phosphorylation site [posttranslational modification] 573370004153 intermolecular recognition site; other site 573370004154 dimerization interface [polypeptide binding]; other site 573370004155 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370004156 dimer interface [polypeptide binding]; other site 573370004157 phosphorylation site [posttranslational modification] 573370004158 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370004159 ATP binding site [chemical binding]; other site 573370004160 Mg2+ binding site [ion binding]; other site 573370004161 G-X-G motif; other site 573370004162 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573370004163 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370004164 dimer interface [polypeptide binding]; other site 573370004165 phosphorylation site [posttranslational modification] 573370004166 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370004167 ATP binding site [chemical binding]; other site 573370004168 Mg2+ binding site [ion binding]; other site 573370004169 G-X-G motif; other site 573370004170 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 573370004171 methionine sulfoxide reductase B; Provisional; Region: PRK00222 573370004172 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370004173 active site 573370004174 phosphorylation site [posttranslational modification] 573370004175 intermolecular recognition site; other site 573370004176 dimerization interface [polypeptide binding]; other site 573370004177 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 573370004178 Domain of unknown function (DUF362); Region: DUF362; pfam04015 573370004179 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 573370004180 active site 573370004181 cosubstrate binding site; other site 573370004182 substrate binding site [chemical binding]; other site 573370004183 catalytic site [active] 573370004184 Flp/Fap pilin component; Region: Flp_Fap; cl01585 573370004185 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573370004186 Zn2+ binding site [ion binding]; other site 573370004187 Mg2+ binding site [ion binding]; other site 573370004188 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 573370004189 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 573370004190 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 573370004191 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 573370004192 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 573370004193 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 573370004194 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 573370004195 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 573370004196 NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; Region: NuoK; COG0713 573370004197 NADH-ubiquinone/plastoquinone oxidoreductase chain 6; Region: Oxidored_q3; cl17265 573370004198 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 573370004199 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 573370004200 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 573370004201 NADH dehydrogenase subunit G; Validated; Region: PRK08166 573370004202 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 573370004203 catalytic loop [active] 573370004204 iron binding site [ion binding]; other site 573370004205 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 573370004206 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 573370004207 molybdopterin cofactor binding site; other site 573370004208 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 573370004209 molybdopterin cofactor binding site; other site 573370004210 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 573370004211 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 573370004212 SLBB domain; Region: SLBB; pfam10531 573370004213 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 573370004214 Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257 573370004215 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 573370004216 putative dimer interface [polypeptide binding]; other site 573370004217 [2Fe-2S] cluster binding site [ion binding]; other site 573370004218 trifunctional NADH dehydrogenase I subunit B/C/D; Provisional; Region: PRK13292 573370004219 NADH dehydrogenase subunit B; Validated; Region: PRK06411 573370004220 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl19197 573370004221 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 573370004222 NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; Region: NuoA; COG0838 573370004223 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 573370004224 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 573370004225 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573370004226 active site 573370004227 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573370004228 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573370004229 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 573370004230 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573370004231 putative ADP-binding pocket [chemical binding]; other site 573370004232 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 573370004233 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 573370004234 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 573370004235 HlyD family secretion protein; Region: HlyD_3; pfam13437 573370004236 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573370004237 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573370004238 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 573370004239 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 573370004240 FOG: CBS domain [General function prediction only]; Region: COG0517 573370004241 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370004242 metal binding site [ion binding]; metal-binding site 573370004243 active site 573370004244 I-site; other site 573370004245 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 573370004246 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573370004247 active site 573370004248 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 573370004249 NeuB family; Region: NeuB; pfam03102 573370004250 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 573370004251 NeuB binding interface [polypeptide binding]; other site 573370004252 putative substrate binding site [chemical binding]; other site 573370004253 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 573370004254 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573370004255 Walker A/P-loop; other site 573370004256 ATP binding site [chemical binding]; other site 573370004257 Q-loop/lid; other site 573370004258 ABC transporter signature motif; other site 573370004259 Walker B; other site 573370004260 D-loop; other site 573370004261 H-loop/switch region; other site 573370004262 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 573370004263 O-antigen ligase like membrane protein; Region: O-antigen_lig; cl04850 573370004264 O-Antigen ligase; Region: Wzy_C; pfam04932 573370004265 Putative catalytic NodB homology domain of uncharacterized prokaryotic polysaccharide deacetylases which consist of a 6-stranded beta/alpha barrel; Region: CE4_DAC_u1_6s; cd10970 573370004266 putative active site [active] 573370004267 putative metal binding site [ion binding]; other site 573370004268 tRNA-splicing ligase RtcB; Region: RtcB; pfam01139 573370004269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078 573370004270 acetoacetate metabolism regulatory protein AtoC; Provisional; Region: PRK11361 573370004271 active site 573370004272 phosphorylation site [posttranslational modification] 573370004273 dimerization interface [polypeptide binding]; other site 573370004274 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370004275 Walker A motif; other site 573370004276 ATP binding site [chemical binding]; other site 573370004277 Walker B motif; other site 573370004278 arginine finger; other site 573370004279 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 573370004280 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573370004281 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl19139 573370004282 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 573370004283 Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187 573370004284 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 573370004285 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 573370004286 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 573370004287 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573370004288 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 573370004289 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 573370004290 active site 573370004291 PHP Thumb interface [polypeptide binding]; other site 573370004292 metal binding site [ion binding]; metal-binding site 573370004293 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 573370004294 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 573370004295 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 573370004296 generic binding surface II; other site 573370004297 generic binding surface I; other site 573370004298 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 573370004299 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573370004300 active site 573370004301 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 573370004302 active site 573370004303 D-tyrosyl-tRNA(Tyr) deacylase; Provisional; Region: PRK05273 573370004304 putative active site [active] 573370004305 dimerization interface [polypeptide binding]; other site 573370004306 putative tRNAtyr binding site [nucleotide binding]; other site 573370004307 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 573370004308 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 573370004309 anti sigma factor interaction site; other site 573370004310 regulatory phosphorylation site [posttranslational modification]; other site 573370004311 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 573370004312 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 573370004313 Tetratricopeptide repeat; Region: TPR_16; pfam13432 573370004314 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 573370004315 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 573370004316 active site 573370004317 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573370004318 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 573370004319 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 573370004320 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 573370004321 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 573370004322 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 573370004323 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 573370004324 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 573370004325 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 573370004326 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 573370004327 flagellin; Reviewed; Region: PRK08869 573370004328 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 573370004329 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 573370004330 ribonuclease III; Reviewed; Region: rnc; PRK00102 573370004331 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 573370004332 dimerization interface [polypeptide binding]; other site 573370004333 active site 573370004334 metal binding site [ion binding]; metal-binding site 573370004335 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 573370004336 dsRNA binding site [nucleotide binding]; other site 573370004337 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 573370004338 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573370004339 DRTGG domain; Region: DRTGG; pfam07085 573370004340 FOG: CBS domain [General function prediction only]; Region: COG0517 573370004341 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611 573370004342 FOG: CBS domain [General function prediction only]; Region: COG0517 573370004343 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611 573370004344 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 573370004345 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370004346 putative active site [active] 573370004347 heme pocket [chemical binding]; other site 573370004348 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370004349 dimer interface [polypeptide binding]; other site 573370004350 phosphorylation site [posttranslational modification] 573370004351 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370004352 ATP binding site [chemical binding]; other site 573370004353 Mg2+ binding site [ion binding]; other site 573370004354 G-X-G motif; other site 573370004355 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370004356 active site 573370004357 phosphorylation site [posttranslational modification] 573370004358 intermolecular recognition site; other site 573370004359 dimerization interface [polypeptide binding]; other site 573370004360 Putative pyruvate format-lyase activating enzyme (DUF1786); Region: DUF1786; cl01638 573370004361 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 573370004362 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573370004363 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 573370004364 dimerization interface [polypeptide binding]; other site 573370004365 substrate binding pocket [chemical binding]; other site 573370004366 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 573370004367 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 573370004368 Uncharacterized conserved protein [Function unknown]; Region: COG1284 573370004369 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 573370004370 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 573370004371 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 573370004372 putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK05641 573370004373 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 573370004374 NAD+ binding site [chemical binding]; other site 573370004375 substrate binding site [chemical binding]; other site 573370004376 Zn binding site [ion binding]; other site 573370004377 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 573370004378 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 573370004379 TonB C terminal; Region: TonB_2; pfam13103 573370004380 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 573370004381 TolB amino-terminal domain; Region: TolB_N; pfam04052 573370004382 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 573370004383 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 573370004384 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 573370004385 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 573370004386 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 573370004387 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 573370004388 ligand binding site [chemical binding]; other site 573370004389 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 573370004390 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 573370004391 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370004392 binding surface 573370004393 TPR motif; other site 573370004394 PAS fold; Region: PAS_4; pfam08448 573370004395 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370004396 putative active site [active] 573370004397 heme pocket [chemical binding]; other site 573370004398 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370004399 metal binding site [ion binding]; metal-binding site 573370004400 active site 573370004401 I-site; other site 573370004402 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 573370004403 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 573370004404 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 573370004405 tetramer interfaces [polypeptide binding]; other site 573370004406 binuclear metal-binding site [ion binding]; other site 573370004407 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 573370004408 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 573370004409 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370004410 dimerization interface [polypeptide binding]; other site 573370004411 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370004412 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 573370004413 dimer interface [polypeptide binding]; other site 573370004414 putative CheW interface [polypeptide binding]; other site 573370004415 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 573370004416 GAF domain; Region: GAF_3; pfam13492 573370004417 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370004418 Walker A motif; other site 573370004419 ATP binding site [chemical binding]; other site 573370004420 Walker B motif; other site 573370004421 arginine finger; other site 573370004422 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 573370004423 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 573370004424 putative active site [active] 573370004425 putative metal binding residues [ion binding]; other site 573370004426 signature motif; other site 573370004427 putative triphosphate binding site [ion binding]; other site 573370004428 dimer interface [polypeptide binding]; other site 573370004429 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 573370004430 EamA-like transporter family; Region: EamA; pfam00892 573370004431 EamA-like transporter family; Region: EamA; pfam00892 573370004432 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; cl19502 573370004433 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 573370004434 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573370004435 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573370004436 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 573370004437 AMP-binding enzyme; Region: AMP-binding; pfam00501 573370004438 acyl-activating enzyme (AAE) consensus motif; other site 573370004439 AMP binding site [chemical binding]; other site 573370004440 active site 573370004441 CoA binding site [chemical binding]; other site 573370004442 benzoate transport; Region: 2A0115; TIGR00895 573370004443 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573370004444 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 573370004445 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573370004446 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573370004447 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 573370004448 dimerization interface [polypeptide binding]; other site 573370004449 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 573370004450 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 573370004451 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 573370004452 TadE-like protein; Region: TadE; pfam07811 573370004453 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 573370004454 TadE-like protein; Region: TadE; pfam07811 573370004455 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573370004456 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370004457 active site 573370004458 phosphorylation site [posttranslational modification] 573370004459 intermolecular recognition site; other site 573370004460 dimerization interface [polypeptide binding]; other site 573370004461 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573370004462 DNA binding residues [nucleotide binding] 573370004463 dimerization interface [polypeptide binding]; other site 573370004464 CHASE4 domain; Region: CHASE4; cl01308 573370004465 HAMP domain; Region: HAMP; pfam00672 573370004466 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370004467 PAS fold; Region: PAS_3; pfam08447 573370004468 putative active site [active] 573370004469 heme pocket [chemical binding]; other site 573370004470 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 573370004471 Histidine kinase; Region: HisKA_3; pfam07730 573370004472 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370004473 ATP binding site [chemical binding]; other site 573370004474 Mg2+ binding site [ion binding]; other site 573370004475 G-X-G motif; other site 573370004476 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 573370004477 Winged helix-turn helix; Region: HTH_29; pfam13551 573370004478 Helix-turn-helix domain; Region: HTH_28; pfam13518 573370004479 Homeodomain-like domain; Region: HTH_32; pfam13565 573370004480 Winged helix-turn helix; Region: HTH_33; pfam13592 573370004481 DDE superfamily endonuclease; Region: DDE_3; pfam13358 573370004482 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 573370004483 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370004484 active site 573370004485 phosphorylation site [posttranslational modification] 573370004486 intermolecular recognition site; other site 573370004487 dimerization interface [polypeptide binding]; other site 573370004488 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370004489 Walker A motif; other site 573370004490 ATP binding site [chemical binding]; other site 573370004491 Walker B motif; other site 573370004492 arginine finger; other site 573370004493 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 573370004494 Sensory domain found in PocR; Region: PocR; pfam10114 573370004495 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370004496 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 573370004497 putative active site [active] 573370004498 heme pocket [chemical binding]; other site 573370004499 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370004500 ATP binding site [chemical binding]; other site 573370004501 Mg2+ binding site [ion binding]; other site 573370004502 G-X-G motif; other site 573370004503 Domain of unknown function (DUF336); Region: DUF336; pfam03928 573370004504 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 573370004505 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 573370004506 dimer interface [polypeptide binding]; other site 573370004507 active site 573370004508 glycine loop; other site 573370004509 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 573370004510 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 573370004511 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573370004512 FeS/SAM binding site; other site 573370004513 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573370004514 Tetratricopeptide repeat; Region: TPR_10; pfam13374 573370004515 Transposase domain (DUF772); Region: DUF772; pfam05598 573370004516 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 573370004517 active site 573370004518 catalytic residues [active] 573370004519 DNA binding site [nucleotide binding] 573370004520 Int/Topo IB signature motif; other site 573370004521 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 573370004522 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 573370004523 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 573370004524 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 573370004525 CRISPR/Cas system-associated protein Cas3; Region: Cas3_I; cd09639 573370004526 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752 573370004527 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757 573370004528 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09689 573370004529 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 573370004530 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 573370004531 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 573370004532 Transposase domain (DUF772); Region: DUF772; pfam05598 573370004533 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573370004534 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 573370004535 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370004536 Walker A motif; other site 573370004537 ATP binding site [chemical binding]; other site 573370004538 Walker B motif; other site 573370004539 potential frameshift: common BLAST hit: gi|187922213|ref|YP_001893855.1| Integrase catalytic region 573370004540 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 573370004541 Integrase core domain; Region: rve; pfam00665 573370004542 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 573370004543 Predicted transcriptional regulator [Transcription]; Region: COG2932 573370004544 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 573370004545 Catalytic site [active] 573370004546 Integrase core domain; Region: rve; pfam00665 573370004547 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 573370004548 AAA domain; Region: AAA_22; pfam13401 573370004549 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; pfam07352 573370004550 Protein of unknown function (DUF1018); Region: DUF1018; cl01815 573370004551 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 573370004552 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573370004553 active site 573370004554 DNA binding site [nucleotide binding] 573370004555 Int/Topo IB signature motif; other site 573370004556 Conjugal transfer protein TraD; Region: TraD; pfam06412 573370004557 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 573370004558 MobA/MobL family; Region: MobA_MobL; pfam03389 573370004559 AAA domain; Region: AAA_30; pfam13604 573370004560 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 573370004561 AAA-like domain; Region: AAA_10; pfam12846 573370004562 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 573370004563 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 573370004564 metal binding triad [ion binding]; metal-binding site 573370004565 Restriction endonuclease XhoI; Region: XhoI; pfam04555 573370004566 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 573370004567 Methyltransferase domain; Region: Methyltransf_26; pfam13659 573370004568 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 573370004569 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573370004570 active site 573370004571 DNA binding site [nucleotide binding] 573370004572 Int/Topo IB signature motif; other site 573370004573 Restriction endonuclease; Region: Mrr_cat; pfam04471 573370004574 Replication initiator protein A; Region: RPA; cl19398 573370004575 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 573370004576 Walker A motif; other site 573370004577 ATP binding site [chemical binding]; other site 573370004578 Walker B motif; other site 573370004579 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 573370004580 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188 573370004581 active site 573370004582 metal binding site [ion binding]; metal-binding site 573370004583 AAA domain; Region: AAA_25; pfam13481 573370004584 Walker A motif; other site 573370004585 ATP binding site [chemical binding]; other site 573370004586 Walker B motif; other site 573370004587 Homeodomain-like domain; Region: HTH_23; pfam13384 573370004588 Helix-turn-helix domain; Region: HTH_17; pfam12728 573370004589 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 573370004590 Ribonuclease P; Region: Ribonuclease_P; cl00457 573370004591 membrane protein insertase; Provisional; Region: PRK01318 573370004592 YidC periplasmic domain; Region: YidC_periplas; pfam14849 573370004593 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 573370004594 Jag N-terminus; Region: Jag_N; pfam14804 573370004595 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 573370004596 G-X-X-G motif; other site 573370004597 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 573370004598 RxxxH motif; other site 573370004599 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 573370004600 EamA-like transporter family; Region: EamA; pfam00892 573370004601 EamA-like transporter family; Region: EamA; pfam00892 573370004602 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573370004603 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 573370004604 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573370004605 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 573370004606 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573370004607 TPR repeat; Region: TPR_11; pfam13414 573370004608 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370004609 binding surface 573370004610 TPR motif; other site 573370004611 TPR repeat; Region: TPR_11; pfam13414 573370004612 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 573370004613 active site 573370004614 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 573370004615 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 573370004616 putative NAD(P) binding site [chemical binding]; other site 573370004617 dimer interface [polypeptide binding]; other site 573370004618 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 573370004619 The cupredoxin domain of Ubiquinol oxidase subunit II; Region: CuRO_UO_II; cd04212 573370004620 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 573370004621 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 573370004622 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 573370004623 D-pathway; other site 573370004624 Putative ubiquinol binding site [chemical binding]; other site 573370004625 Low-spin heme (heme b) binding site [chemical binding]; other site 573370004626 Putative water exit pathway; other site 573370004627 Binuclear center (heme o3/CuB) [ion binding]; other site 573370004628 K-pathway; other site 573370004629 Putative proton exit pathway; other site 573370004630 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 573370004631 Subunit I/III interface [polypeptide binding]; other site 573370004632 Subunit III/IV interface [polypeptide binding]; other site 573370004633 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 573370004634 Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957 573370004635 putative active site [active] 573370004636 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 573370004637 dimer interface [polypeptide binding]; other site 573370004638 active site 573370004639 glycine-pyridoxal phosphate binding site [chemical binding]; other site 573370004640 folate binding site [chemical binding]; other site 573370004641 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 573370004642 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573370004643 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573370004644 DNA binding residues [nucleotide binding] 573370004645 Anti-sigma-K factor rskA; Region: RskA; pfam10099 573370004646 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 573370004647 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 573370004648 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573370004649 non-specific DNA binding site [nucleotide binding]; other site 573370004650 salt bridge; other site 573370004651 sequence-specific DNA binding site [nucleotide binding]; other site 573370004652 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 573370004653 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 573370004654 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573370004655 ATP binding site [chemical binding]; other site 573370004656 putative Mg++ binding site [ion binding]; other site 573370004657 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573370004658 nucleotide binding region [chemical binding]; other site 573370004659 ATP-binding site [chemical binding]; other site 573370004660 hypothetical protein; Provisional; Region: PRK14709 573370004661 D5 N terminal like; Region: D5_N; pfam08706 573370004662 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 573370004663 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573370004664 active site 573370004665 DNA binding site [nucleotide binding] 573370004666 Int/Topo IB signature motif; other site 573370004667 Helix-turn-helix domain; Region: HTH_17; pfam12728 573370004668 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 573370004669 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 573370004670 active site 573370004671 catalytic residues [active] 573370004672 DNA binding site [nucleotide binding] 573370004673 Int/Topo IB signature motif; other site 573370004674 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 573370004675 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 573370004676 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 573370004677 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 573370004678 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573370004679 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370004680 dimerization interface [polypeptide binding]; other site 573370004681 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370004682 dimer interface [polypeptide binding]; other site 573370004683 phosphorylation site [posttranslational modification] 573370004684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370004685 ATP binding site [chemical binding]; other site 573370004686 Mg2+ binding site [ion binding]; other site 573370004687 G-X-G motif; other site 573370004688 HsdM N-terminal domain; Region: HsdM_N; pfam12161 573370004689 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 573370004690 Methyltransferase domain; Region: Methyltransf_26; pfam13659 573370004691 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 573370004692 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 573370004693 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 573370004694 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 573370004695 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 573370004696 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 573370004697 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573370004698 ATP binding site [chemical binding]; other site 573370004699 putative Mg++ binding site [ion binding]; other site 573370004700 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 573370004701 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 573370004702 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 573370004703 Domain of unknown function (DUF927); Region: DUF927; cl12098 573370004704 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573370004705 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 573370004706 active site 573370004707 DNA binding site [nucleotide binding] 573370004708 Int/Topo IB signature motif; other site 573370004709 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 573370004710 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 573370004711 active site 573370004712 catalytic residues [active] 573370004713 DNA binding site [nucleotide binding] 573370004714 Int/Topo IB signature motif; other site 573370004715 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 573370004716 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573370004717 FeS/SAM binding site; other site 573370004718 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 573370004719 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 573370004720 dimerization interface [polypeptide binding]; other site 573370004721 putative ATP binding site [chemical binding]; other site 573370004722 Transposase; Region: DEDD_Tnp_IS110; pfam01548 573370004723 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 573370004724 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 573370004725 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573370004726 Radical SAM superfamily; Region: Radical_SAM; pfam04055 573370004727 FeS/SAM binding site; other site 573370004728 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 573370004729 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 573370004730 23S rRNA interface [nucleotide binding]; other site 573370004731 L3 interface [polypeptide binding]; other site 573370004732 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 573370004733 HD domain; Region: HD_3; pfam13023 573370004734 FOG: CBS domain [General function prediction only]; Region: COG0517 573370004735 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 573370004736 guanine deaminase; Provisional; Region: PRK09228 573370004737 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 573370004738 active site 573370004739 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 573370004740 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 573370004741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573370004742 putative substrate translocation pore; other site 573370004743 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 573370004744 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 573370004745 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573370004746 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370004747 dimerization interface [polypeptide binding]; other site 573370004748 Histidine kinase; Region: HisKA_3; pfam07730 573370004749 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370004750 ATP binding site [chemical binding]; other site 573370004751 Mg2+ binding site [ion binding]; other site 573370004752 G-X-G motif; other site 573370004753 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573370004754 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370004755 active site 573370004756 phosphorylation site [posttranslational modification] 573370004757 intermolecular recognition site; other site 573370004758 dimerization interface [polypeptide binding]; other site 573370004759 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573370004760 DNA binding residues [nucleotide binding] 573370004761 dimerization interface [polypeptide binding]; other site 573370004762 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 573370004763 active site 573370004764 metal binding site [ion binding]; metal-binding site 573370004765 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 573370004766 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 573370004767 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 573370004768 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 573370004769 active site 573370004770 SAM binding site [chemical binding]; other site 573370004771 homodimer interface [polypeptide binding]; other site 573370004772 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 573370004773 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 573370004774 intersubunit interface [polypeptide binding]; other site 573370004775 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 573370004776 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 573370004777 Walker A/P-loop; other site 573370004778 ATP binding site [chemical binding]; other site 573370004779 Q-loop/lid; other site 573370004780 ABC transporter signature motif; other site 573370004781 Walker B; other site 573370004782 D-loop; other site 573370004783 H-loop/switch region; other site 573370004784 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 573370004785 ABC-ATPase subunit interface; other site 573370004786 dimer interface [polypeptide binding]; other site 573370004787 putative PBP binding regions; other site 573370004788 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 573370004789 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 573370004790 active site 573370004791 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 573370004792 active site 573370004793 N-terminal domain interface [polypeptide binding]; other site 573370004794 intracellular protease, PfpI family; Region: PfpI; TIGR01382 573370004795 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 573370004796 conserved cys residue [active] 573370004797 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 573370004798 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 573370004799 Competence protein; Region: Competence; pfam03772 573370004800 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 573370004801 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 573370004802 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 573370004803 putative substrate-binding site; other site 573370004804 nickel binding site [ion binding]; other site 573370004805 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 573370004806 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 573370004807 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 573370004808 NiFe/NiFeSe hydrogenase small subunit C-terminal; Region: NiFe_hyd_SSU_C; pfam14720 573370004809 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 573370004810 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; cl09920 573370004811 Methylamine utilisation protein MauE; Region: MauE; pfam07291 573370004812 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 573370004813 active site residue [active] 573370004814 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573370004815 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 573370004816 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573370004817 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 573370004818 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 573370004819 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 573370004820 ligand binding site [chemical binding]; other site 573370004821 flagellar motor protein MotA; Validated; Region: PRK09110 573370004822 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 573370004823 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 573370004824 Methyltransferase domain; Region: Methyltransf_31; pfam13847 573370004825 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370004826 S-adenosylmethionine binding site [chemical binding]; other site 573370004827 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 573370004828 Protein involved in formate dehydrogenase formation; Region: FdhE; cl19312 573370004829 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 573370004830 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 573370004831 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 573370004832 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 573370004833 molybdopterin cofactor binding site; other site 573370004834 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 573370004835 molybdopterin cofactor binding site; other site 573370004836 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 573370004837 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 573370004838 Protein involved in formate dehydrogenase formation; Region: FdhE; cl19312 573370004839 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 573370004840 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 573370004841 dimer interface [polypeptide binding]; other site 573370004842 active site 573370004843 citrylCoA binding site [chemical binding]; other site 573370004844 NADH binding [chemical binding]; other site 573370004845 cationic pore residues; other site 573370004846 oxalacetate/citrate binding site [chemical binding]; other site 573370004847 coenzyme A binding site [chemical binding]; other site 573370004848 catalytic triad [active] 573370004849 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 573370004850 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 573370004851 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573370004852 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370004853 dimer interface [polypeptide binding]; other site 573370004854 phosphorylation site [posttranslational modification] 573370004855 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370004856 ATP binding site [chemical binding]; other site 573370004857 Mg2+ binding site [ion binding]; other site 573370004858 G-X-G motif; other site 573370004859 3D domain; Region: 3D; cl01439 573370004860 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 573370004861 K+ potassium transporter; Region: K_trans; pfam02705 573370004862 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 573370004863 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 573370004864 Sel1-like repeats; Region: SEL1; smart00671 573370004865 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 573370004866 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 573370004867 DsrC like protein; Region: DsrC; pfam04358 573370004868 YcaO-like family; Region: YcaO; pfam02624 573370004869 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370004870 binding surface 573370004871 TPR motif; other site 573370004872 TPR repeat; Region: TPR_11; pfam13414 573370004873 potential protein location (hypothetical protein DMR_15910 [Desulfovibrio magneticus RS-1]) that overlaps RNA (tRNA-G) 573370004874 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 573370004875 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 573370004876 putative dimer interface [polypeptide binding]; other site 573370004877 Beta-lactamase; Region: Beta-lactamase; pfam00144 573370004878 Protein of unknown function (DUF523); Region: DUF523; pfam04463 573370004879 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 573370004880 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 573370004881 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 573370004882 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 573370004883 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 573370004884 2-isopropylmalate synthase; Validated; Region: PRK00915 573370004885 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 573370004886 active site 573370004887 catalytic residues [active] 573370004888 metal binding site [ion binding]; metal-binding site 573370004889 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 573370004890 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 573370004891 substrate binding site [chemical binding]; other site 573370004892 ligand binding site [chemical binding]; other site 573370004893 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 573370004894 substrate binding site [chemical binding]; other site 573370004895 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 573370004896 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 573370004897 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573370004898 ABC transporter; Region: ABC_tran_2; pfam12848 573370004899 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573370004900 Cdc37 N terminal kinase binding; Region: CDC37_N; cl03951 573370004901 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 573370004902 active site 573370004903 8-oxo-dGMP binding site [chemical binding]; other site 573370004904 nudix motif; other site 573370004905 metal binding site [ion binding]; metal-binding site 573370004906 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 573370004907 FAD binding site [chemical binding]; other site 573370004908 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 573370004909 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 573370004910 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 573370004911 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 573370004912 homodimer interface [polypeptide binding]; other site 573370004913 substrate-cofactor binding pocket; other site 573370004914 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573370004915 catalytic residue [active] 573370004916 Predicted ATPase [General function prediction only]; Region: COG4637 573370004917 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573370004918 Walker A/P-loop; other site 573370004919 ATP binding site [chemical binding]; other site 573370004920 AAA domain; Region: AAA_21; pfam13304 573370004921 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 573370004922 Tim44-like domain; Region: Tim44; cl09208 573370004923 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370004924 active site 573370004925 phosphorylation site [posttranslational modification] 573370004926 intermolecular recognition site; other site 573370004927 dimerization interface [polypeptide binding]; other site 573370004928 TPR repeat; Region: TPR_11; pfam13414 573370004929 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370004930 binding surface 573370004931 TPR motif; other site 573370004932 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370004933 TPR repeat; Region: TPR_11; pfam13414 573370004934 binding surface 573370004935 TPR motif; other site 573370004936 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573370004937 Zn2+ binding site [ion binding]; other site 573370004938 Mg2+ binding site [ion binding]; other site 573370004939 NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NuoL; COG1009 573370004940 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370004941 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370004942 active site 573370004943 phosphorylation site [posttranslational modification] 573370004944 intermolecular recognition site; other site 573370004945 dimerization interface [polypeptide binding]; other site 573370004946 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 573370004947 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370004948 active site 573370004949 phosphorylation site [posttranslational modification] 573370004950 intermolecular recognition site; other site 573370004951 dimerization interface [polypeptide binding]; other site 573370004952 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 573370004953 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370004954 active site 573370004955 phosphorylation site [posttranslational modification] 573370004956 intermolecular recognition site; other site 573370004957 dimerization interface [polypeptide binding]; other site 573370004958 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370004959 Walker A motif; other site 573370004960 ATP binding site [chemical binding]; other site 573370004961 Walker B motif; other site 573370004962 arginine finger; other site 573370004963 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 573370004964 CHASE3 domain; Region: CHASE3; pfam05227 573370004965 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573370004966 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370004967 dimer interface [polypeptide binding]; other site 573370004968 phosphorylation site [posttranslational modification] 573370004969 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370004970 ATP binding site [chemical binding]; other site 573370004971 Mg2+ binding site [ion binding]; other site 573370004972 G-X-G motif; other site 573370004973 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370004974 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573370004975 dimer interface [polypeptide binding]; other site 573370004976 putative CheW interface [polypeptide binding]; other site 573370004977 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 573370004978 Putative lysophospholipase; Region: Hydrolase_4; cl19140 573370004979 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 573370004980 flagellar motor protein MotB; Reviewed; Region: motB; PRK08944 573370004981 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 573370004982 ligand binding site [chemical binding]; other site 573370004983 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 573370004984 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 573370004985 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 573370004986 ligand binding site [chemical binding]; other site 573370004987 flexible hinge region; other site 573370004988 FliG C-terminal domain; Region: FliG_C; pfam01706 573370004989 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 573370004990 FAD binding pocket [chemical binding]; other site 573370004991 conserved FAD binding motif [chemical binding]; other site 573370004992 phosphate binding motif [ion binding]; other site 573370004993 beta-alpha-beta structure motif; other site 573370004994 NAD binding pocket [chemical binding]; other site 573370004995 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 573370004996 heterodimer interface [polypeptide binding]; other site 573370004997 active site 573370004998 FMN binding site [chemical binding]; other site 573370004999 homodimer interface [polypeptide binding]; other site 573370005000 substrate binding site [chemical binding]; other site 573370005001 Domain of unknown function (DUF389); Region: DUF389; pfam04087 573370005002 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 573370005003 Methyltransferase domain; Region: Methyltransf_31; pfam13847 573370005004 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370005005 S-adenosylmethionine binding site [chemical binding]; other site 573370005006 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573370005007 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 573370005008 FtsX-like permease family; Region: FtsX; pfam02687 573370005009 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573370005010 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 573370005011 FtsX-like permease family; Region: FtsX; pfam02687 573370005012 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 573370005013 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 573370005014 Walker A/P-loop; other site 573370005015 ATP binding site [chemical binding]; other site 573370005016 Q-loop/lid; other site 573370005017 ABC transporter signature motif; other site 573370005018 Walker B; other site 573370005019 D-loop; other site 573370005020 H-loop/switch region; other site 573370005021 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 573370005022 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 573370005023 HlyD family secretion protein; Region: HlyD_3; pfam13437 573370005024 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 573370005025 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 573370005026 minor groove reading motif; other site 573370005027 helix-hairpin-helix signature motif; other site 573370005028 substrate binding pocket [chemical binding]; other site 573370005029 active site 573370005030 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 573370005031 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 573370005032 active site 573370005033 8-oxo-dGMP binding site [chemical binding]; other site 573370005034 nudix motif; other site 573370005035 metal binding site [ion binding]; metal-binding site 573370005036 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 573370005037 Predicted transcriptional regulator [Transcription]; Region: COG1959 573370005038 Rrf2 family protein; Region: rrf2_super; TIGR00738 573370005039 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 573370005040 adenylate kinase; Provisional; Region: PRK14529 573370005041 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 573370005042 AMP-binding site [chemical binding]; other site 573370005043 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 573370005044 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 573370005045 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 573370005046 Ligand Binding Site [chemical binding]; other site 573370005047 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 573370005048 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 573370005049 tRNA; other site 573370005050 putative tRNA binding site [nucleotide binding]; other site 573370005051 putative NADP binding site [chemical binding]; other site 573370005052 Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745 573370005053 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 573370005054 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 573370005055 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 573370005056 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573370005057 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 573370005058 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 573370005059 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 573370005060 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 573370005061 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 573370005062 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 573370005063 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 573370005064 potential protein location (hypothetical protein DMR_16480 [Desulfovibrio magneticus RS-1]) that overlaps RNA (16S ribosomal RNA) 573370005065 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 573370005066 amino acid transporter; Region: 2A0306; TIGR00909 573370005067 LrgA family; Region: LrgA; cl00608 573370005068 LrgB-like family; Region: LrgB; pfam04172 573370005069 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 573370005070 AIR carboxylase; Region: AIRC; smart01001 573370005071 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 573370005072 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 573370005073 Ligand Binding Site [chemical binding]; other site 573370005074 hypothetical protein; Provisional; Region: PRK04194 573370005075 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 573370005076 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 573370005077 active site 573370005078 catalytic tetrad [active] 573370005079 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 573370005080 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 573370005081 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 573370005082 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573370005083 PAS domain S-box; Region: sensory_box; TIGR00229 573370005084 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370005085 putative active site [active] 573370005086 heme pocket [chemical binding]; other site 573370005087 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370005088 metal binding site [ion binding]; metal-binding site 573370005089 active site 573370005090 I-site; other site 573370005091 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 573370005092 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 573370005093 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 573370005094 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 573370005095 dimer interface [polypeptide binding]; other site 573370005096 putative CheW interface [polypeptide binding]; other site 573370005097 FeoA domain; Region: FeoA; pfam04023 573370005098 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 573370005099 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 573370005100 G1 box; other site 573370005101 GTP/Mg2+ binding site [chemical binding]; other site 573370005102 Switch I region; other site 573370005103 G2 box; other site 573370005104 G3 box; other site 573370005105 Switch II region; other site 573370005106 G4 box; other site 573370005107 G5 box; other site 573370005108 Nucleoside recognition; Region: Gate; pfam07670 573370005109 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 573370005110 Nucleoside recognition; Region: Gate; pfam07670 573370005111 ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266 573370005112 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 573370005113 putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/unknown domain fusion protein; Provisional; Region: PRK14495 573370005114 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 573370005115 putative deacylase active site [active] 573370005116 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 573370005117 dimer interface [polypeptide binding]; other site 573370005118 active site 573370005119 metal binding site [ion binding]; metal-binding site 573370005120 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 573370005121 GAF domain; Region: GAF; pfam01590 573370005122 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370005123 putative active site [active] 573370005124 heme pocket [chemical binding]; other site 573370005125 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370005126 Walker A motif; other site 573370005127 ATP binding site [chemical binding]; other site 573370005128 Walker B motif; other site 573370005129 arginine finger; other site 573370005130 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 573370005131 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 573370005132 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573370005133 ATP binding site [chemical binding]; other site 573370005134 putative Mg++ binding site [ion binding]; other site 573370005135 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573370005136 nucleotide binding region [chemical binding]; other site 573370005137 ATP-binding site [chemical binding]; other site 573370005138 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 573370005139 HRDC domain; Region: HRDC; pfam00570 573370005140 Helix-turn-helix domain; Region: HTH_40; pfam14493 573370005141 Inner membrane protein CreD; Region: CreD; cl01844 573370005142 AIR carboxylase; Region: AIRC; pfam00731 573370005143 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 573370005144 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 573370005145 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 573370005146 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 573370005147 Cache domain; Region: Cache_1; pfam02743 573370005148 PAS domain; Region: PAS_9; pfam13426 573370005149 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 573370005150 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370005151 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573370005152 dimer interface [polypeptide binding]; other site 573370005153 putative CheW interface [polypeptide binding]; other site 573370005154 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370005155 dimerization interface [polypeptide binding]; other site 573370005156 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370005157 PAS domain; Region: PAS_9; pfam13426 573370005158 putative active site [active] 573370005159 heme pocket [chemical binding]; other site 573370005160 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370005161 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573370005162 dimer interface [polypeptide binding]; other site 573370005163 putative CheW interface [polypeptide binding]; other site 573370005164 Cache domain; Region: Cache_2; cl07034 573370005165 PAS domain; Region: PAS_9; pfam13426 573370005166 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370005167 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573370005168 dimer interface [polypeptide binding]; other site 573370005169 putative CheW interface [polypeptide binding]; other site 573370005170 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 573370005171 PAS domain; Region: PAS_9; pfam13426 573370005172 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 573370005173 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370005174 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573370005175 dimer interface [polypeptide binding]; other site 573370005176 putative CheW interface [polypeptide binding]; other site 573370005177 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 573370005178 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 573370005179 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573370005180 ABC transporter signature motif; other site 573370005181 Walker B; other site 573370005182 D-loop; other site 573370005183 H-loop/switch region; other site 573370005184 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573370005185 Walker A/P-loop; other site 573370005186 ATP binding site [chemical binding]; other site 573370005187 Q-loop/lid; other site 573370005188 ABC transporter signature motif; other site 573370005189 Walker B; other site 573370005190 D-loop; other site 573370005191 H-loop/switch region; other site 573370005192 Peptidase family U32; Region: Peptidase_U32; cl03113 573370005193 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 573370005194 Ligand Binding Site [chemical binding]; other site 573370005195 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 573370005196 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 573370005197 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573370005198 FeS/SAM binding site; other site 573370005199 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 573370005200 active site 573370005201 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 573370005202 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 573370005203 Inositol hexakisphosphate; Region: PTPlike_phytase; pfam14566 573370005204 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 573370005205 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 573370005206 active site 573370005207 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 573370005208 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 573370005209 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 573370005210 active site 573370005211 catalytic triad [active] 573370005212 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 573370005213 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 573370005214 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 573370005215 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 573370005216 DNA binding site [nucleotide binding] 573370005217 catalytic residue [active] 573370005218 H2TH interface [polypeptide binding]; other site 573370005219 putative catalytic residues [active] 573370005220 turnover-facilitating residue; other site 573370005221 intercalation triad [nucleotide binding]; other site 573370005222 8OG recognition residue [nucleotide binding]; other site 573370005223 putative reading head residues; other site 573370005224 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 573370005225 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 573370005226 Protein of unknown function, DUF399; Region: DUF399; pfam04187 573370005227 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 573370005228 protein binding site [polypeptide binding]; other site 573370005229 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 573370005230 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 573370005231 acyl-activating enzyme (AAE) consensus motif; other site 573370005232 AMP binding site [chemical binding]; other site 573370005233 active site 573370005234 CoA binding site [chemical binding]; other site 573370005235 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370005236 dimer interface [polypeptide binding]; other site 573370005237 phosphorylation site [posttranslational modification] 573370005238 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370005239 ATP binding site [chemical binding]; other site 573370005240 Mg2+ binding site [ion binding]; other site 573370005241 G-X-G motif; other site 573370005242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370005243 active site 573370005244 phosphorylation site [posttranslational modification] 573370005245 intermolecular recognition site; other site 573370005246 dimerization interface [polypeptide binding]; other site 573370005247 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 573370005248 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 573370005249 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573370005250 FeS/SAM binding site; other site 573370005251 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 573370005252 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 573370005253 homodimer interface [polypeptide binding]; other site 573370005254 oligonucleotide binding site [chemical binding]; other site 573370005255 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 573370005256 Uncharacterized BCR, COG1636; Region: DUF208; cl17782 573370005257 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which binds to Adenosine group; Region: Alpha_ANH_like; cd01986 573370005258 Ligand Binding Site [chemical binding]; other site 573370005259 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 573370005260 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 573370005261 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 573370005262 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 573370005263 Nucleoside diphosphate kinase; Region: NDK; pfam00334 573370005264 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 573370005265 active site 573370005266 multimer interface [polypeptide binding]; other site 573370005267 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 573370005268 FOG: CBS domain [General function prediction only]; Region: COG0517 573370005269 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 573370005270 FOG: CBS domain [General function prediction only]; Region: COG0517 573370005271 FOG: CBS domain [General function prediction only]; Region: COG0517 573370005272 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 573370005273 CrcB-like protein; Region: CRCB; cl09114 573370005274 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 573370005275 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 573370005276 trimerization site [polypeptide binding]; other site 573370005277 active site 573370005278 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 573370005279 NifU-like domain; Region: NifU; pfam01106 573370005280 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 573370005281 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573370005282 catalytic residue [active] 573370005283 cysteine synthase; Region: PLN02565 573370005284 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 573370005285 dimer interface [polypeptide binding]; other site 573370005286 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573370005287 catalytic residue [active] 573370005288 serine O-acetyltransferase; Region: cysE; TIGR01172 573370005289 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 573370005290 trimer interface [polypeptide binding]; other site 573370005291 active site 573370005292 substrate binding site [chemical binding]; other site 573370005293 CoA binding site [chemical binding]; other site 573370005294 TOBE domain; Region: TOBE; cl01440 573370005295 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 573370005296 Uncharacterized conserved protein [Function unknown]; Region: COG3461 573370005297 TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase; Region: TPM; cl01535 573370005298 TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase; Region: TPM; cl01535 573370005299 LemA family; Region: LemA; pfam04011 573370005300 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 573370005301 active site 573370005302 hypothetical protein; Provisional; Region: PRK06361 573370005303 Bifunctional nuclease; Region: DNase-RNase; pfam02577 573370005304 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14337 573370005305 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 573370005306 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573370005307 FeS/SAM binding site; other site 573370005308 TRAM domain; Region: TRAM; cl01282 573370005309 fumarate hydratase; Reviewed; Region: fumC; PRK00485 573370005310 Class II fumarases; Region: Fumarase_classII; cd01362 573370005311 active site 573370005312 tetramer interface [polypeptide binding]; other site 573370005313 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 573370005314 D-serine dehydratase; Provisional; Region: PRK02991 573370005315 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573370005316 catalytic residue [active] 573370005317 IBR domain; Region: IBR; cl19760 573370005318 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 573370005319 active site 573370005320 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 573370005321 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 573370005322 substrate binding site [chemical binding]; other site 573370005323 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 573370005324 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 573370005325 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 573370005326 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 573370005327 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 573370005328 Ligand Binding Site [chemical binding]; other site 573370005329 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 573370005330 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 573370005331 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 573370005332 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 573370005333 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 573370005334 nucleotide binding site [chemical binding]; other site 573370005335 NEF interaction site [polypeptide binding]; other site 573370005336 SBD interface [polypeptide binding]; other site 573370005337 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 573370005338 dimer interface [polypeptide binding]; other site 573370005339 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 573370005340 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 573370005341 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 573370005342 HrcA protein C terminal domain; Region: HrcA; pfam01628 573370005343 Transcriptional regulators [Transcription]; Region: FadR; COG2186 573370005344 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573370005345 DNA-binding site [nucleotide binding]; DNA binding site 573370005346 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 573370005347 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 573370005348 4Fe-4S binding domain; Region: Fer4_5; pfam12801 573370005349 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 573370005350 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 573370005351 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 573370005352 nucleophilic elbow; other site 573370005353 catalytic triad; other site 573370005354 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 573370005355 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573370005356 Walker A/P-loop; other site 573370005357 ATP binding site [chemical binding]; other site 573370005358 Q-loop/lid; other site 573370005359 ABC transporter signature motif; other site 573370005360 Walker B; other site 573370005361 D-loop; other site 573370005362 H-loop/switch region; other site 573370005363 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 573370005364 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573370005365 dimer interface [polypeptide binding]; other site 573370005366 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 573370005367 conserved gate region; other site 573370005368 putative PBP binding loops; other site 573370005369 ABC-ATPase subunit interface; other site 573370005370 Flagellar protein YcgR; Region: YcgR_2; pfam12945 573370005371 PilZ domain; Region: PilZ; pfam07238 573370005372 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370005373 binding surface 573370005374 TPR motif; other site 573370005375 TPR repeat; Region: TPR_11; pfam13414 573370005376 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 573370005377 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573370005378 FeS/SAM binding site; other site 573370005379 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 573370005380 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 573370005381 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 573370005382 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 573370005383 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 573370005384 tetramerization interface [polypeptide binding]; other site 573370005385 NAD(P) binding site [chemical binding]; other site 573370005386 catalytic residues [active] 573370005387 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 573370005388 active site 573370005389 metal binding site [ion binding]; metal-binding site 573370005390 Domain of unknown function DUF77; Region: DUF77; pfam01910 573370005391 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 573370005392 Transglycosylase; Region: Transgly; pfam00912 573370005393 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 573370005394 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 573370005395 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 573370005396 active site 573370005397 phosphorylation site [posttranslational modification] 573370005398 intermolecular recognition site; other site 573370005399 dimerization interface [polypeptide binding]; other site 573370005400 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370005401 active site 573370005402 phosphorylation site [posttranslational modification] 573370005403 intermolecular recognition site; other site 573370005404 dimerization interface [polypeptide binding]; other site 573370005405 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 573370005406 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 573370005407 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 573370005408 non-heme iron binding site [ion binding]; other site 573370005409 dimer interface [polypeptide binding]; other site 573370005410 Superoxide reductase-like (SORL) domain, class I; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_Dfx_classI; cd03171 573370005411 non-heme iron binding site [ion binding]; other site 573370005412 dimer interface [polypeptide binding]; other site 573370005413 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 573370005414 Ferritin-like domain; Region: Ferritin; pfam00210 573370005415 ferroxidase diiron center [ion binding]; other site 573370005416 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 573370005417 putative FMN binding site [chemical binding]; other site 573370005418 NADPH bind site [chemical binding]; other site 573370005419 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 573370005420 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370005421 ATP binding site [chemical binding]; other site 573370005422 Mg2+ binding site [ion binding]; other site 573370005423 G-X-G motif; other site 573370005424 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 573370005425 ATP binding site [chemical binding]; other site 573370005426 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 573370005427 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 573370005428 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 573370005429 active site 573370005430 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 573370005431 dimer interface [polypeptide binding]; other site 573370005432 substrate binding site [chemical binding]; other site 573370005433 catalytic residues [active] 573370005434 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 573370005435 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 573370005436 minor groove reading motif; other site 573370005437 helix-hairpin-helix signature motif; other site 573370005438 substrate binding pocket [chemical binding]; other site 573370005439 active site 573370005440 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 573370005441 Peptidase family M23; Region: Peptidase_M23; pfam01551 573370005442 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 573370005443 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 573370005444 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 573370005445 protein binding site [polypeptide binding]; other site 573370005446 Catalytic dyad [active] 573370005447 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 573370005448 NodB motif; other site 573370005449 putative active site [active] 573370005450 putative catalytic site [active] 573370005451 Zn binding site [ion binding]; other site 573370005452 CHASE2 domain; Region: CHASE2; pfam05226 573370005453 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 573370005454 cyclase homology domain; Region: CHD; cd07302 573370005455 nucleotidyl binding site; other site 573370005456 metal binding site [ion binding]; metal-binding site 573370005457 dimer interface [polypeptide binding]; other site 573370005458 TOBE domain; Region: TOBE; cl01440 573370005459 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370005460 metal binding site [ion binding]; metal-binding site 573370005461 active site 573370005462 I-site; other site 573370005463 uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904 573370005464 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 573370005465 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 573370005466 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 573370005467 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 573370005468 phosphate binding site [ion binding]; other site 573370005469 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370005470 putative active site [active] 573370005471 PAS fold; Region: PAS_3; pfam08447 573370005472 heme pocket [chemical binding]; other site 573370005473 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 573370005474 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573370005475 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370005476 ATP binding site [chemical binding]; other site 573370005477 Mg2+ binding site [ion binding]; other site 573370005478 G-X-G motif; other site 573370005479 acetyl-CoA synthetase; Provisional; Region: PRK00174 573370005480 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 573370005481 active site 573370005482 CoA binding site [chemical binding]; other site 573370005483 acyl-activating enzyme (AAE) consensus motif; other site 573370005484 AMP binding site [chemical binding]; other site 573370005485 acetate binding site [chemical binding]; other site 573370005486 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 573370005487 Putative zinc ribbon domain; Region: DUF164; pfam02591 573370005488 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 573370005489 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 573370005490 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 573370005491 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 573370005492 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370005493 PAS domain; Region: PAS_9; pfam13426 573370005494 putative active site [active] 573370005495 heme pocket [chemical binding]; other site 573370005496 PAS domain S-box; Region: sensory_box; TIGR00229 573370005497 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370005498 putative active site [active] 573370005499 heme pocket [chemical binding]; other site 573370005500 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370005501 dimer interface [polypeptide binding]; other site 573370005502 phosphorylation site [posttranslational modification] 573370005503 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370005504 ATP binding site [chemical binding]; other site 573370005505 Mg2+ binding site [ion binding]; other site 573370005506 G-X-G motif; other site 573370005507 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370005508 active site 573370005509 phosphorylation site [posttranslational modification] 573370005510 intermolecular recognition site; other site 573370005511 dimerization interface [polypeptide binding]; other site 573370005512 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 573370005513 FOG: WD40 repeat [General function prediction only]; Region: COG2319 573370005514 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 573370005515 structural tetrad; other site 573370005516 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 573370005517 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 573370005518 P-loop, Walker A motif; other site 573370005519 Base recognition motif; other site 573370005520 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 573370005521 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 573370005522 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 573370005523 Ligand Binding Site [chemical binding]; other site 573370005524 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 573370005525 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 573370005526 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 573370005527 active site 573370005528 catalytic residues [active] 573370005529 metal binding site [ion binding]; metal-binding site 573370005530 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 573370005531 aspartate kinase; Reviewed; Region: PRK06635 573370005532 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 573370005533 putative nucleotide binding site [chemical binding]; other site 573370005534 putative catalytic residues [active] 573370005535 putative Mg ion binding site [ion binding]; other site 573370005536 putative aspartate binding site [chemical binding]; other site 573370005537 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 573370005538 putative allosteric regulatory site; other site 573370005539 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 573370005540 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 573370005541 FOG: CBS domain [General function prediction only]; Region: COG0517 573370005542 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 573370005543 putative carbohydrate kinase; Provisional; Region: PRK10565 573370005544 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 573370005545 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 573370005546 putative substrate binding site [chemical binding]; other site 573370005547 putative ATP binding site [chemical binding]; other site 573370005548 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 573370005549 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 573370005550 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 573370005551 NlpC/P60 family; Region: NLPC_P60; pfam00877 573370005552 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 573370005553 catalytic loop [active] 573370005554 iron binding site [ion binding]; other site 573370005555 Domain of unknown function (DUF4445); Region: DUF4445; pfam14574 573370005556 Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847 573370005557 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 573370005558 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 573370005559 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 573370005560 Substrate binding site; other site 573370005561 Cupin domain; Region: Cupin_2; cl17218 573370005562 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 573370005563 heme-binding residues [chemical binding]; other site 573370005564 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 573370005565 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 573370005566 molybdopterin cofactor binding site; other site 573370005567 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 573370005568 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 573370005569 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 573370005570 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 573370005571 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 573370005572 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 573370005573 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 573370005574 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 573370005575 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 573370005576 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573370005577 motif II; other site 573370005578 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 573370005579 HprK-related kinase B; Region: HprK_rel_B; TIGR04355 573370005580 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 573370005581 active site 573370005582 metal-binding site [ion binding] 573370005583 nucleotide-binding site [chemical binding]; other site 573370005584 ATP-grasp enzyme, GAK system; Region: grasp_GAK; TIGR04356 573370005585 ATP-grasp domain; Region: ATP-grasp_4; cl17255 573370005586 Phosphate uptake regulator [Inorganic ion transport and metabolism]; Region: PhoU; COG0704 573370005587 PhoU domain; Region: PhoU; pfam01895 573370005588 PhoU domain; Region: PhoU; pfam01895 573370005589 Ecdysteroid kinase; Region: EcKinase; cl17738 573370005590 amphi-Trp domain; Region: amphi-Trp; TIGR04354 573370005591 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 573370005592 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 573370005593 coproporphyrinogen III oxidase; Provisional; Region: PRK07379 573370005594 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573370005595 FeS/SAM binding site; other site 573370005596 HemN C-terminal domain; Region: HemN_C; pfam06969 573370005597 putative peptidase; Provisional; Region: PRK11649 573370005598 Peptidase family M23; Region: Peptidase_M23; pfam01551 573370005599 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 573370005600 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 573370005601 putative active site [active] 573370005602 catalytic site [active] 573370005603 putative metal binding site [ion binding]; other site 573370005604 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 573370005605 PilZ domain; Region: PilZ; pfam07238 573370005606 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370005607 TPR motif; other site 573370005608 TPR repeat; Region: TPR_11; pfam13414 573370005609 binding surface 573370005610 TPR repeat; Region: TPR_11; pfam13414 573370005611 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370005612 binding surface 573370005613 TPR motif; other site 573370005614 TPR repeat; Region: TPR_11; pfam13414 573370005615 L-aspartate oxidase; Provisional; Region: PRK06175 573370005616 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 573370005617 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 573370005618 quinolinate synthetase; Provisional; Region: PRK09375 573370005619 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 573370005620 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 573370005621 dimerization interface [polypeptide binding]; other site 573370005622 active site 573370005623 recombination factor protein RarA; Reviewed; Region: PRK13342 573370005624 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370005625 Walker A motif; other site 573370005626 ATP binding site [chemical binding]; other site 573370005627 Walker B motif; other site 573370005628 arginine finger; other site 573370005629 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 573370005630 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 573370005631 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 573370005632 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 573370005633 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 573370005634 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 573370005635 GAF domain; Region: GAF_3; pfam13492 573370005636 rod shape-determining protein MreB; Provisional; Region: PRK13930 573370005637 MreB and similar proteins; Region: MreB_like; cd10225 573370005638 nucleotide binding site [chemical binding]; other site 573370005639 Mg binding site [ion binding]; other site 573370005640 putative protofilament interaction site [polypeptide binding]; other site 573370005641 RodZ interaction site [polypeptide binding]; other site 573370005642 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 573370005643 active site 573370005644 dimerization interface [polypeptide binding]; other site 573370005645 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 573370005646 nudix motif; other site 573370005647 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573370005648 Coenzyme A binding pocket [chemical binding]; other site 573370005649 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 573370005650 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 573370005651 substrate binding site [chemical binding]; other site 573370005652 hinge regions; other site 573370005653 ADP binding site [chemical binding]; other site 573370005654 catalytic site [active] 573370005655 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 573370005656 substrate binding site [chemical binding]; other site 573370005657 catalytic triad [active] 573370005658 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 573370005659 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 573370005660 INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184 573370005661 Int/Topo IB signature motif; other site 573370005662 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 573370005663 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 573370005664 Part of AAA domain; Region: AAA_19; pfam13245 573370005665 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 573370005666 Restriction endonuclease BglII; Region: Endonuc-BglII; pfam09195 573370005667 Domain of unknown function (DUF932); Region: DUF932; cl12129 573370005668 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 573370005669 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 573370005670 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 573370005671 CheB methylesterase; Region: CheB_methylest; pfam01339 573370005672 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 573370005673 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 573370005674 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 573370005675 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 573370005676 PAS domain; Region: PAS_10; pfam13596 573370005677 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370005678 PAS domain; Region: PAS_9; pfam13426 573370005679 putative active site [active] 573370005680 heme pocket [chemical binding]; other site 573370005681 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370005682 PAS domain; Region: PAS_9; pfam13426 573370005683 putative active site [active] 573370005684 heme pocket [chemical binding]; other site 573370005685 PAS domain S-box; Region: sensory_box; TIGR00229 573370005686 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370005687 putative active site [active] 573370005688 heme pocket [chemical binding]; other site 573370005689 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370005690 dimer interface [polypeptide binding]; other site 573370005691 phosphorylation site [posttranslational modification] 573370005692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370005693 ATP binding site [chemical binding]; other site 573370005694 Mg2+ binding site [ion binding]; other site 573370005695 G-X-G motif; other site 573370005696 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370005697 active site 573370005698 phosphorylation site [posttranslational modification] 573370005699 intermolecular recognition site; other site 573370005700 dimerization interface [polypeptide binding]; other site 573370005701 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 573370005702 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 573370005703 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370005704 binding surface 573370005705 TPR motif; other site 573370005706 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370005707 binding surface 573370005708 TPR motif; other site 573370005709 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 573370005710 Sel1-like repeats; Region: SEL1; smart00671 573370005711 Helix-turn-helix domain; Region: HTH_28; pfam13518 573370005712 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573370005713 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 573370005714 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 573370005715 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573370005716 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 573370005717 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370005718 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 573370005719 Walker A motif; other site 573370005720 ATP binding site [chemical binding]; other site 573370005721 Walker B motif; other site 573370005722 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 573370005723 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 573370005724 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370005725 metal binding site [ion binding]; metal-binding site 573370005726 active site 573370005727 I-site; other site 573370005728 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 573370005729 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370005730 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370005731 putative active site [active] 573370005732 heme pocket [chemical binding]; other site 573370005733 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370005734 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370005735 putative active site [active] 573370005736 heme pocket [chemical binding]; other site 573370005737 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370005738 putative active site [active] 573370005739 heme pocket [chemical binding]; other site 573370005740 GAF domain; Region: GAF_2; pfam13185 573370005741 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370005742 PAS fold; Region: PAS_3; pfam08447 573370005743 putative active site [active] 573370005744 heme pocket [chemical binding]; other site 573370005745 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370005746 dimer interface [polypeptide binding]; other site 573370005747 phosphorylation site [posttranslational modification] 573370005748 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370005749 ATP binding site [chemical binding]; other site 573370005750 Mg2+ binding site [ion binding]; other site 573370005751 G-X-G motif; other site 573370005752 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370005753 active site 573370005754 phosphorylation site [posttranslational modification] 573370005755 intermolecular recognition site; other site 573370005756 dimerization interface [polypeptide binding]; other site 573370005757 MAEBL; Provisional; Region: PTZ00121 573370005758 Hantavirus nucleocapsid protein; Region: Hanta_nucleocap; pfam00846 573370005759 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 573370005760 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 573370005761 HTH-like domain; Region: HTH_21; pfam13276 573370005762 Integrase core domain; Region: rve; pfam00665 573370005763 Integrase core domain; Region: rve_3; pfam13683 573370005764 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 573370005765 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 573370005766 DNA-binding interface [nucleotide binding]; DNA binding site 573370005767 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 573370005768 GIY-YIG motif/motif A; other site 573370005769 putative active site [active] 573370005770 putative metal binding site [ion binding]; other site 573370005771 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 573370005772 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 573370005773 Helix-hairpin-helix containing domain; Region: HHH_4; pfam14490 573370005774 AAA domain; Region: AAA_30; pfam13604 573370005775 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 573370005776 Uncharacterized conserved protein (DUF2290); Region: DUF2290; cl02396 573370005777 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 573370005778 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 573370005779 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 573370005780 substrate binding site [chemical binding]; other site 573370005781 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 573370005782 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 573370005783 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659 573370005784 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 573370005785 dimer interface [polypeptide binding]; other site 573370005786 PYR/PP interface [polypeptide binding]; other site 573370005787 TPP binding site [chemical binding]; other site 573370005788 substrate binding site [chemical binding]; other site 573370005789 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 573370005790 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 573370005791 TPP-binding site [chemical binding]; other site 573370005792 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 573370005793 Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045 573370005794 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 573370005795 CoA-ligase; Region: Ligase_CoA; pfam00549 573370005796 CoA binding domain; Region: CoA_binding; smart00881 573370005797 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 573370005798 CoA-ligase; Region: Ligase_CoA; pfam00549 573370005799 PAS fold; Region: PAS_4; pfam08448 573370005800 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370005801 putative active site [active] 573370005802 heme pocket [chemical binding]; other site 573370005803 Bacterial protein of unknown function (DUF881); Region: DUF881; cl19849 573370005804 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 573370005805 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370005806 dimer interface [polypeptide binding]; other site 573370005807 phosphorylation site [posttranslational modification] 573370005808 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370005809 ATP binding site [chemical binding]; other site 573370005810 Mg2+ binding site [ion binding]; other site 573370005811 G-X-G motif; other site 573370005812 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 573370005813 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573370005814 Zn2+ binding site [ion binding]; other site 573370005815 Mg2+ binding site [ion binding]; other site 573370005816 Ion channel; Region: Ion_trans_2; pfam07885 573370005817 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 573370005818 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 573370005819 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 573370005820 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 573370005821 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 573370005822 homodimer interaction site [polypeptide binding]; other site 573370005823 cofactor binding site; other site 573370005824 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 573370005825 EamA-like transporter family; Region: EamA; pfam00892 573370005826 thiamine monophosphate kinase; Provisional; Region: PRK05731 573370005827 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 573370005828 ATP binding site [chemical binding]; other site 573370005829 dimerization interface [polypeptide binding]; other site 573370005830 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 573370005831 substrate binding site [chemical binding]; other site 573370005832 ATP binding site [chemical binding]; other site 573370005833 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 573370005834 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 573370005835 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370005836 active site 573370005837 phosphorylation site [posttranslational modification] 573370005838 intermolecular recognition site; other site 573370005839 dimerization interface [polypeptide binding]; other site 573370005840 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370005841 Walker A motif; other site 573370005842 ATP binding site [chemical binding]; other site 573370005843 Walker B motif; other site 573370005844 arginine finger; other site 573370005845 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 573370005846 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370005847 S-adenosylmethionine binding site [chemical binding]; other site 573370005848 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 573370005849 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 573370005850 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 573370005851 substrate-cofactor binding pocket; other site 573370005852 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573370005853 catalytic residue [active] 573370005854 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 573370005855 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 573370005856 inhibitor-cofactor binding pocket; inhibition site 573370005857 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573370005858 catalytic residue [active] 573370005859 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573370005860 magnesium transport protein MgtC; Provisional; Region: PRK15385 573370005861 MgtC family; Region: MgtC; pfam02308 573370005862 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 573370005863 putative active site; other site 573370005864 catalytic residue [active] 573370005865 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 573370005866 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 573370005867 hinge; other site 573370005868 active site 573370005869 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370005870 active site 573370005871 phosphorylation site [posttranslational modification] 573370005872 intermolecular recognition site; other site 573370005873 dimerization interface [polypeptide binding]; other site 573370005874 STAS domain; Region: STAS_2; pfam13466 573370005875 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 573370005876 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 573370005877 putative binding surface; other site 573370005878 active site 573370005879 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 573370005880 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370005881 ATP binding site [chemical binding]; other site 573370005882 Mg2+ binding site [ion binding]; other site 573370005883 G-X-G motif; other site 573370005884 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 573370005885 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 573370005886 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370005887 dimerization interface [polypeptide binding]; other site 573370005888 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370005889 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 573370005890 dimer interface [polypeptide binding]; other site 573370005891 putative CheW interface [polypeptide binding]; other site 573370005892 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 573370005893 putative CheA interaction surface; other site 573370005894 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 573370005895 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 573370005896 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 573370005897 active site 573370005898 nucleotide binding site [chemical binding]; other site 573370005899 HIGH motif; other site 573370005900 KMSKS motif; other site 573370005901 Putative zinc- or iron-chelating domain; Region: CxxCxxCC; pfam03692 573370005902 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370005903 ATP binding site [chemical binding]; other site 573370005904 Mg2+ binding site [ion binding]; other site 573370005905 G-X-G motif; other site 573370005906 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 573370005907 anti sigma factor interaction site; other site 573370005908 regulatory phosphorylation site [posttranslational modification]; other site 573370005909 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 573370005910 G1 box; other site 573370005911 GTP/Mg2+ binding site [chemical binding]; other site 573370005912 G2 box; other site 573370005913 Switch I region; other site 573370005914 G3 box; other site 573370005915 Switch II region; other site 573370005916 G4 box; other site 573370005917 G5 box; other site 573370005918 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 573370005919 Catalytic site; other site 573370005920 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 573370005921 Protein export membrane protein; Region: SecD_SecF; pfam02355 573370005922 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573370005923 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370005924 active site 573370005925 phosphorylation site [posttranslational modification] 573370005926 intermolecular recognition site; other site 573370005927 dimerization interface [polypeptide binding]; other site 573370005928 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370005929 TPR repeat; Region: TPR_11; pfam13414 573370005930 binding surface 573370005931 TPR motif; other site 573370005932 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 573370005933 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 573370005934 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 573370005935 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 573370005936 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 573370005937 TOBE domain; Region: TOBE; cl01440 573370005938 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 573370005939 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 573370005940 Transposase domain (DUF772); Region: DUF772; pfam05598 573370005941 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573370005942 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 573370005943 oxyanion hole [active] 573370005944 potential frameshift: common BLAST hit: gi|148259801|ref|YP_001233928.1| transposase, mutator type 573370005945 Transposase, Mutator family; Region: Transposase_mut; cl19537 573370005946 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 573370005947 Transposase, Mutator family; Region: Transposase_mut; cl19537 573370005948 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 573370005949 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 573370005950 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573370005951 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573370005952 homodimer interface [polypeptide binding]; other site 573370005953 catalytic residue [active] 573370005954 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573370005955 putative substrate translocation pore; other site 573370005956 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573370005957 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 573370005958 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 573370005959 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 573370005960 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 573370005961 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 573370005962 catalytic loop [active] 573370005963 iron binding site [ion binding]; other site 573370005964 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 573370005965 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 573370005966 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 573370005967 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 573370005968 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 573370005969 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 573370005970 acyl-activating enzyme (AAE) consensus motif; other site 573370005971 AMP binding site [chemical binding]; other site 573370005972 active site 573370005973 CoA binding site [chemical binding]; other site 573370005974 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573370005975 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 573370005976 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 573370005977 active site 573370005978 metal binding site [ion binding]; metal-binding site 573370005979 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 573370005980 active site 573370005981 Zn binding site [ion binding]; other site 573370005982 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 573370005983 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 573370005984 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573370005985 catalytic residue [active] 573370005986 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 573370005987 active site 573370005988 catalytic residues [active] 573370005989 DNA binding site [nucleotide binding] 573370005990 Int/Topo IB signature motif; other site 573370005991 TOBE domain; Region: TOBE; cl01440 573370005992 TOBE domain; Region: TOBE; cl01440 573370005993 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 573370005994 Probable pheophorbidase; Region: PLN02965; cl17657 573370005995 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573370005996 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 573370005997 Walker A/P-loop; other site 573370005998 ATP binding site [chemical binding]; other site 573370005999 Q-loop/lid; other site 573370006000 ABC transporter signature motif; other site 573370006001 Walker B; other site 573370006002 D-loop; other site 573370006003 H-loop/switch region; other site 573370006004 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 573370006005 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573370006006 dimer interface [polypeptide binding]; other site 573370006007 conserved gate region; other site 573370006008 putative PBP binding loops; other site 573370006009 ABC-ATPase subunit interface; other site 573370006010 FeoA domain; Region: FeoA; pfam04023 573370006011 FeoA domain; Region: FeoA; pfam04023 573370006012 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 573370006013 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 573370006014 Chemoreceptor zinc-binding domain; Region: CZB; pfam13682 573370006015 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370006016 dimerization interface [polypeptide binding]; other site 573370006017 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370006018 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573370006019 dimer interface [polypeptide binding]; other site 573370006020 putative CheW interface [polypeptide binding]; other site 573370006021 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 573370006022 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 573370006023 Walker A/P-loop; other site 573370006024 ATP binding site [chemical binding]; other site 573370006025 Q-loop/lid; other site 573370006026 ABC transporter signature motif; other site 573370006027 Walker B; other site 573370006028 D-loop; other site 573370006029 H-loop/switch region; other site 573370006030 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573370006031 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 573370006032 FtsX-like permease family; Region: FtsX; pfam02687 573370006033 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 573370006034 sensor protein ZraS; Provisional; Region: PRK10364 573370006035 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 573370006036 PAS fold; Region: PAS_4; pfam08448 573370006037 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370006038 putative active site [active] 573370006039 heme pocket [chemical binding]; other site 573370006040 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370006041 dimer interface [polypeptide binding]; other site 573370006042 phosphorylation site [posttranslational modification] 573370006043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370006044 ATP binding site [chemical binding]; other site 573370006045 Mg2+ binding site [ion binding]; other site 573370006046 G-X-G motif; other site 573370006047 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 573370006048 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370006049 active site 573370006050 phosphorylation site [posttranslational modification] 573370006051 intermolecular recognition site; other site 573370006052 dimerization interface [polypeptide binding]; other site 573370006053 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370006054 Walker A motif; other site 573370006055 ATP binding site [chemical binding]; other site 573370006056 Walker B motif; other site 573370006057 arginine finger; other site 573370006058 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 573370006059 AMP-binding domain protein; Validated; Region: PRK08315 573370006060 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 573370006061 acyl-activating enzyme (AAE) consensus motif; other site 573370006062 putative AMP binding site [chemical binding]; other site 573370006063 putative active site [active] 573370006064 putative CoA binding site [chemical binding]; other site 573370006065 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573370006066 non-specific DNA binding site [nucleotide binding]; other site 573370006067 salt bridge; other site 573370006068 sequence-specific DNA binding site [nucleotide binding]; other site 573370006069 Cupin domain; Region: Cupin_2; pfam07883 573370006070 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573370006071 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573370006072 non-specific DNA binding site [nucleotide binding]; other site 573370006073 salt bridge; other site 573370006074 sequence-specific DNA binding site [nucleotide binding]; other site 573370006075 Cupin domain; Region: Cupin_2; pfam07883 573370006076 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 573370006077 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 573370006078 acyl-activating enzyme (AAE) consensus motif; other site 573370006079 AMP binding site [chemical binding]; other site 573370006080 active site 573370006081 CoA binding site [chemical binding]; other site 573370006082 Transposase; Region: DEDD_Tnp_IS110; pfam01548 573370006083 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 573370006084 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 573370006085 Ion channel; Region: Ion_trans_2; pfam07885 573370006086 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 573370006087 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 573370006088 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 573370006089 HupE / UreJ protein; Region: HupE_UreJ; cl01011 573370006090 High-affinity nickel-transport protein; Region: NicO; cl00964 573370006091 Protein of unknown function, DUF485; Region: DUF485; pfam04341 573370006092 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 573370006093 Na binding site [ion binding]; other site 573370006094 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 573370006095 metal binding triad; other site 573370006096 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 573370006097 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 573370006098 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 573370006099 ligand binding site [chemical binding]; other site 573370006100 flexible hinge region; other site 573370006101 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 573370006102 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 573370006103 metal binding triad [ion binding]; metal-binding site 573370006104 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; cl19627 573370006105 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 573370006106 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 573370006107 active site 573370006108 catalytic site [active] 573370006109 substrate binding site [chemical binding]; other site 573370006110 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 573370006111 metal binding site 2 [ion binding]; metal-binding site 573370006112 putative DNA binding helix; other site 573370006113 metal binding site 1 [ion binding]; metal-binding site 573370006114 dimer interface [polypeptide binding]; other site 573370006115 structural Zn2+ binding site [ion binding]; other site 573370006116 Rubrerythrin [Energy production and conversion]; Region: COG1592 573370006117 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 573370006118 binuclear metal center [ion binding]; other site 573370006119 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 573370006120 iron binding site [ion binding]; other site 573370006121 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 573370006122 Rubredoxin [Energy production and conversion]; Region: COG1773 573370006123 iron binding site [ion binding]; other site 573370006124 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 573370006125 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 573370006126 P-loop; other site 573370006127 PilZ domain; Region: PilZ; cl01260 573370006128 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370006129 ATP binding site [chemical binding]; other site 573370006130 Mg2+ binding site [ion binding]; other site 573370006131 G-X-G motif; other site 573370006132 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 573370006133 Rhomboid family; Region: Rhomboid; cl11446 573370006134 Bacterial PH domain; Region: bPH_2; pfam03703 573370006135 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573370006136 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370006137 dimerization interface [polypeptide binding]; other site 573370006138 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370006139 dimer interface [polypeptide binding]; other site 573370006140 phosphorylation site [posttranslational modification] 573370006141 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370006142 ATP binding site [chemical binding]; other site 573370006143 Mg2+ binding site [ion binding]; other site 573370006144 G-X-G motif; other site 573370006145 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 573370006146 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370006147 active site 573370006148 phosphorylation site [posttranslational modification] 573370006149 intermolecular recognition site; other site 573370006150 dimerization interface [polypeptide binding]; other site 573370006151 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370006152 Walker A motif; other site 573370006153 ATP binding site [chemical binding]; other site 573370006154 Walker B motif; other site 573370006155 arginine finger; other site 573370006156 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 573370006157 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 573370006158 FtsX-like permease family; Region: FtsX; pfam02687 573370006159 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 573370006160 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 573370006161 Walker A/P-loop; other site 573370006162 ATP binding site [chemical binding]; other site 573370006163 Q-loop/lid; other site 573370006164 ABC transporter signature motif; other site 573370006165 Walker B; other site 573370006166 D-loop; other site 573370006167 H-loop/switch region; other site 573370006168 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 573370006169 PA/protease or protease-like domain interface [polypeptide binding]; other site 573370006170 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573370006171 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 573370006172 FtsX-like permease family; Region: FtsX; pfam02687 573370006173 OPT oligopeptide transporter protein; Region: OPT; cl14607 573370006174 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 573370006175 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370006176 dimerization interface [polypeptide binding]; other site 573370006177 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370006178 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573370006179 dimer interface [polypeptide binding]; other site 573370006180 putative CheW interface [polypeptide binding]; other site 573370006181 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 573370006182 chaperone protein DnaJ; Provisional; Region: PRK14301 573370006183 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 573370006184 HSP70 interaction site [polypeptide binding]; other site 573370006185 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 573370006186 substrate binding site [polypeptide binding]; other site 573370006187 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 573370006188 Zn binding sites [ion binding]; other site 573370006189 dimer interface [polypeptide binding]; other site 573370006190 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370006191 binding surface 573370006192 TPR repeat; Region: TPR_11; pfam13414 573370006193 TPR motif; other site 573370006194 TPR repeat; Region: TPR_11; pfam13414 573370006195 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 573370006196 trimer interface [polypeptide binding]; other site 573370006197 dimer interface [polypeptide binding]; other site 573370006198 putative active site [active] 573370006199 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 573370006200 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 573370006201 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 573370006202 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 573370006203 Cysteine-rich domain; Region: CCG; pfam02754 573370006204 Cysteine-rich domain; Region: CCG; pfam02754 573370006205 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 573370006206 L-lactate permease; Region: Lactate_perm; cl00701 573370006207 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 573370006208 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573370006209 DRTGG domain; Region: DRTGG; pfam07085 573370006210 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 573370006211 CoA binding domain; Region: CoA_binding_2; pfam13380 573370006212 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 573370006213 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 573370006214 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 573370006215 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 573370006216 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 573370006217 Cysteine-rich domain; Region: CCG; pfam02754 573370006218 Cysteine-rich domain; Region: CCG; pfam02754 573370006219 FAD binding domain; Region: FAD_binding_4; pfam01565 573370006220 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 573370006221 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 573370006222 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 573370006223 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 573370006224 dimer interface [polypeptide binding]; other site 573370006225 PYR/PP interface [polypeptide binding]; other site 573370006226 TPP binding site [chemical binding]; other site 573370006227 substrate binding site [chemical binding]; other site 573370006228 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 573370006229 Domain of unknown function; Region: EKR; pfam10371 573370006230 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 573370006231 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 573370006232 TPP-binding site [chemical binding]; other site 573370006233 dimer interface [polypeptide binding]; other site 573370006234 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 573370006235 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370006236 active site 573370006237 phosphorylation site [posttranslational modification] 573370006238 intermolecular recognition site; other site 573370006239 dimerization interface [polypeptide binding]; other site 573370006240 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370006241 Walker A motif; other site 573370006242 ATP binding site [chemical binding]; other site 573370006243 Walker B motif; other site 573370006244 arginine finger; other site 573370006245 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 573370006246 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370006247 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370006248 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370006249 putative active site [active] 573370006250 heme pocket [chemical binding]; other site 573370006251 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573370006252 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370006253 dimer interface [polypeptide binding]; other site 573370006254 phosphorylation site [posttranslational modification] 573370006255 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370006256 ATP binding site [chemical binding]; other site 573370006257 Mg2+ binding site [ion binding]; other site 573370006258 G-X-G motif; other site 573370006259 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370006260 active site 573370006261 phosphorylation site [posttranslational modification] 573370006262 intermolecular recognition site; other site 573370006263 dimerization interface [polypeptide binding]; other site 573370006264 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 573370006265 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 573370006266 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 573370006267 P loop; other site 573370006268 GTP binding site [chemical binding]; other site 573370006269 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 573370006270 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 573370006271 Predicted permeases [General function prediction only]; Region: COG0701 573370006272 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 573370006273 Sulfate transporter family; Region: Sulfate_transp; cl19250 573370006274 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573370006275 dimerization interface [polypeptide binding]; other site 573370006276 putative DNA binding site [nucleotide binding]; other site 573370006277 putative Zn2+ binding site [ion binding]; other site 573370006278 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 573370006279 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 573370006280 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 573370006281 putative dimer interface [polypeptide binding]; other site 573370006282 putative anticodon binding site; other site 573370006283 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 573370006284 homodimer interface [polypeptide binding]; other site 573370006285 motif 1; other site 573370006286 motif 2; other site 573370006287 active site 573370006288 motif 3; other site 573370006289 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 573370006290 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 573370006291 Ligand binding site; other site 573370006292 Putative Catalytic site; other site 573370006293 DXD motif; other site 573370006294 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370006295 S-adenosylmethionine binding site [chemical binding]; other site 573370006296 Sensory domain found in PocR; Region: PocR; pfam10114 573370006297 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370006298 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370006299 putative active site [active] 573370006300 heme pocket [chemical binding]; other site 573370006301 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370006302 putative active site [active] 573370006303 heme pocket [chemical binding]; other site 573370006304 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573370006305 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370006306 dimer interface [polypeptide binding]; other site 573370006307 phosphorylation site [posttranslational modification] 573370006308 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370006309 ATP binding site [chemical binding]; other site 573370006310 Mg2+ binding site [ion binding]; other site 573370006311 G-X-G motif; other site 573370006312 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 573370006313 active site 573370006314 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573370006315 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 573370006316 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 573370006317 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 573370006318 FOG: CBS domain [General function prediction only]; Region: COG0517 573370006319 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370006320 metal binding site [ion binding]; metal-binding site 573370006321 active site 573370006322 I-site; other site 573370006323 phosphate transporter ATP-binding protein; Provisional; Region: PRK14242 573370006324 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 573370006325 Walker A/P-loop; other site 573370006326 ATP binding site [chemical binding]; other site 573370006327 Q-loop/lid; other site 573370006328 ABC transporter signature motif; other site 573370006329 Walker B; other site 573370006330 D-loop; other site 573370006331 H-loop/switch region; other site 573370006332 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 573370006333 PhoU domain; Region: PhoU; pfam01895 573370006334 PhoU domain; Region: PhoU; pfam01895 573370006335 HprK-related kinase B; Region: HprK_rel_B; TIGR04355 573370006336 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 573370006337 active site 573370006338 metal-binding site [ion binding] 573370006339 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 573370006340 phosphate binding site [ion binding]; other site 573370006341 putative substrate binding pocket [chemical binding]; other site 573370006342 dimer interface [polypeptide binding]; other site 573370006343 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 573370006344 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 573370006345 Cl binding site [ion binding]; other site 573370006346 oligomer interface [polypeptide binding]; other site 573370006347 Hemerythrin; Region: Hemerythrin; cd12107 573370006348 Fe binding site [ion binding]; other site 573370006349 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 573370006350 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 573370006351 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370006352 TPR motif; other site 573370006353 binding surface 573370006354 Tetratricopeptide repeat; Region: TPR_19; pfam14559 573370006355 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370006356 TPR motif; other site 573370006357 TPR repeat; Region: TPR_11; pfam13414 573370006358 binding surface 573370006359 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 573370006360 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 573370006361 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 573370006362 catalytic site [active] 573370006363 subunit interface [polypeptide binding]; other site 573370006364 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 573370006365 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 573370006366 ATP-grasp domain; Region: ATP-grasp_4; cl17255 573370006367 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573370006368 Zn2+ binding site [ion binding]; other site 573370006369 Mg2+ binding site [ion binding]; other site 573370006370 HupF/HypC family; Region: HupF_HypC; pfam01455 573370006371 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 573370006372 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 573370006373 dimerization interface [polypeptide binding]; other site 573370006374 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 573370006375 ATP binding site [chemical binding]; other site 573370006376 dihydrodipicolinate reductase; Provisional; Region: PRK00048 573370006377 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 573370006378 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 573370006379 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 573370006380 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573370006381 ATP binding site [chemical binding]; other site 573370006382 putative Mg++ binding site [ion binding]; other site 573370006383 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573370006384 nucleotide binding region [chemical binding]; other site 573370006385 ATP-binding site [chemical binding]; other site 573370006386 DEAD/H associated; Region: DEAD_assoc; pfam08494 573370006387 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; cl19202 573370006388 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 573370006389 NAD(P) binding pocket [chemical binding]; other site 573370006390 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573370006391 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370006392 binding surface 573370006393 TPR motif; other site 573370006394 Tetratricopeptide repeat; Region: TPR_19; pfam14559 573370006395 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370006396 active site 573370006397 phosphorylation site [posttranslational modification] 573370006398 intermolecular recognition site; other site 573370006399 dimerization interface [polypeptide binding]; other site 573370006400 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 573370006401 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370006402 TPR motif; other site 573370006403 binding surface 573370006404 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573370006405 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370006406 binding surface 573370006407 TPR motif; other site 573370006408 Predicted membrane protein (DUF2207); Region: DUF2207; cl19878 573370006409 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 573370006410 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 573370006411 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370006412 putative active site [active] 573370006413 heme pocket [chemical binding]; other site 573370006414 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370006415 dimer interface [polypeptide binding]; other site 573370006416 phosphorylation site [posttranslational modification] 573370006417 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370006418 ATP binding site [chemical binding]; other site 573370006419 Mg2+ binding site [ion binding]; other site 573370006420 G-X-G motif; other site 573370006421 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 573370006422 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 573370006423 molybdopterin cofactor binding site; other site 573370006424 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 573370006425 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 573370006426 TPR repeat; Region: TPR_11; pfam13414 573370006427 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370006428 binding surface 573370006429 TPR motif; other site 573370006430 TPR repeat; Region: TPR_11; pfam13414 573370006431 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370006432 binding surface 573370006433 TPR motif; other site 573370006434 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 573370006435 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370006436 binding surface 573370006437 TPR motif; other site 573370006438 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370006439 binding surface 573370006440 TPR motif; other site 573370006441 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 573370006442 dimer interface [polypeptide binding]; other site 573370006443 [2Fe-2S] cluster binding site [ion binding]; other site 573370006444 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 573370006445 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 573370006446 nitrogenase vanadium-iron protein, alpha chain; Region: VNFD; TIGR01860 573370006447 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 573370006448 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 573370006449 Nitrogen regulatory protein P-II; Region: P-II; smart00938 573370006450 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 573370006451 nitrogenase iron protein; Region: nifH; TIGR01287 573370006452 Nucleotide-binding sites [chemical binding]; other site 573370006453 Walker A motif; other site 573370006454 Switch I region of nucleotide binding site; other site 573370006455 Fe4S4 binding sites [ion binding]; other site 573370006456 Switch II region of nucleotide binding site; other site 573370006457 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 573370006458 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 573370006459 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 573370006460 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 573370006461 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 573370006462 RNA binding site [nucleotide binding]; other site 573370006463 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 573370006464 nicotinate phosphoribosyltransferase; Reviewed; Region: PRK08662 573370006465 active site 573370006466 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 573370006467 catalytic triad [active] 573370006468 conserved cis-peptide bond; other site 573370006469 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370006470 metal binding site [ion binding]; metal-binding site 573370006471 active site 573370006472 I-site; other site 573370006473 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573370006474 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573370006475 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 573370006476 histone-like DNA-binding protein HU; Region: HU; cd13831 573370006477 dimer interface [polypeptide binding]; other site 573370006478 DNA binding site [nucleotide binding] 573370006479 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 573370006480 Yqey-like protein; Region: YqeY; pfam09424 573370006481 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 573370006482 MutS domain III; Region: MutS_III; pfam05192 573370006483 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573370006484 Walker A/P-loop; other site 573370006485 ATP binding site [chemical binding]; other site 573370006486 Q-loop/lid; other site 573370006487 ABC transporter signature motif; other site 573370006488 Walker B; other site 573370006489 D-loop; other site 573370006490 H-loop/switch region; other site 573370006491 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 573370006492 Smr domain; Region: Smr; pfam01713 573370006493 DNA primase; Validated; Region: dnaG; PRK05667 573370006494 CHC2 zinc finger; Region: zf-CHC2; cl17510 573370006495 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 573370006496 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 573370006497 active site 573370006498 metal binding site [ion binding]; metal-binding site 573370006499 interdomain interaction site; other site 573370006500 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 573370006501 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 573370006502 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 573370006503 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573370006504 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 573370006505 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573370006506 DNA binding residues [nucleotide binding] 573370006507 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 573370006508 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 573370006509 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 573370006510 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 573370006511 Beta-Casp domain; Region: Beta-Casp; smart01027 573370006512 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 573370006513 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 573370006514 rRNA binding site [nucleotide binding]; other site 573370006515 predicted 30S ribosome binding site; other site 573370006516 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 573370006517 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 573370006518 putative CheA interaction surface; other site 573370006519 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 573370006520 Bifunctional transglycosylase second domain; Region: UB2H; pfam14814 573370006521 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 573370006522 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573370006523 ATP binding site [chemical binding]; other site 573370006524 putative Mg++ binding site [ion binding]; other site 573370006525 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573370006526 nucleotide binding region [chemical binding]; other site 573370006527 ATP-binding site [chemical binding]; other site 573370006528 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 573370006529 SurA N-terminal domain; Region: SurA_N_3; cl07813 573370006530 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 573370006531 Fungal domain of unknown function (DUF1750); Region: SWI-SNF_Ssr4; pfam08549 573370006532 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 573370006533 SurA N-terminal domain; Region: SurA_N; pfam09312 573370006534 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 573370006535 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 573370006536 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573370006537 non-specific DNA binding site [nucleotide binding]; other site 573370006538 salt bridge; other site 573370006539 sequence-specific DNA binding site [nucleotide binding]; other site 573370006540 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 573370006541 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 573370006542 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 573370006543 Recombination protein O N terminal; Region: RecO_N; pfam11967 573370006544 Recombination protein O C terminal; Region: RecO_C; pfam02565 573370006545 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 573370006546 dimer interface [polypeptide binding]; other site 573370006547 motif 1; other site 573370006548 active site 573370006549 motif 2; other site 573370006550 motif 3; other site 573370006551 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 573370006552 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 573370006553 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 573370006554 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 573370006555 Dienelactone hydrolase family; Region: DLH; pfam01738 573370006556 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 573370006557 Zn binding site [ion binding]; other site 573370006558 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 573370006559 thiamine-monophosphate kinase; Region: thiL; TIGR01379 573370006560 dimerization interface [polypeptide binding]; other site 573370006561 putative ATP binding site [chemical binding]; other site 573370006562 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573370006563 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573370006564 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573370006565 Walker A/P-loop; other site 573370006566 ATP binding site [chemical binding]; other site 573370006567 Q-loop/lid; other site 573370006568 ABC transporter signature motif; other site 573370006569 Walker B; other site 573370006570 D-loop; other site 573370006571 H-loop/switch region; other site 573370006572 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 573370006573 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 573370006574 active site 573370006575 catalytic residues [active] 573370006576 metal binding site [ion binding]; metal-binding site 573370006577 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 573370006578 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 573370006579 conserved cys residue [active] 573370006580 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 573370006581 putative active site [active] 573370006582 YdjC motif; other site 573370006583 Mg binding site [ion binding]; other site 573370006584 putative homodimer interface [polypeptide binding]; other site 573370006585 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188 573370006586 putative active site [active] 573370006587 metal binding site [ion binding]; metal-binding site 573370006588 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370006589 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370006590 putative active site [active] 573370006591 heme pocket [chemical binding]; other site 573370006592 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370006593 dimer interface [polypeptide binding]; other site 573370006594 phosphorylation site [posttranslational modification] 573370006595 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370006596 ATP binding site [chemical binding]; other site 573370006597 Mg2+ binding site [ion binding]; other site 573370006598 G-X-G motif; other site 573370006599 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 573370006600 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 573370006601 G1 box; other site 573370006602 putative GEF interaction site [polypeptide binding]; other site 573370006603 GTP/Mg2+ binding site [chemical binding]; other site 573370006604 Switch I region; other site 573370006605 G2 box; other site 573370006606 G3 box; other site 573370006607 Switch II region; other site 573370006608 G4 box; other site 573370006609 G5 box; other site 573370006610 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 573370006611 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 573370006612 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 573370006613 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370006614 dimerization interface [polypeptide binding]; other site 573370006615 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 573370006616 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 573370006617 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 573370006618 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 573370006619 FMN binding site [chemical binding]; other site 573370006620 dimer interface [polypeptide binding]; other site 573370006621 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 573370006622 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 573370006623 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 573370006624 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 573370006625 substrate binding site [chemical binding]; other site 573370006626 glutamase interaction surface [polypeptide binding]; other site 573370006627 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 573370006628 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 573370006629 putative active site [active] 573370006630 oxyanion strand; other site 573370006631 catalytic triad [active] 573370006632 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 573370006633 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 573370006634 NADP binding site [chemical binding]; other site 573370006635 homopentamer interface [polypeptide binding]; other site 573370006636 substrate binding site [chemical binding]; other site 573370006637 active site 573370006638 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 573370006639 putative active site [active] 573370006640 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 573370006641 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 573370006642 TPP-binding site [chemical binding]; other site 573370006643 dimer interface [polypeptide binding]; other site 573370006644 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 573370006645 PYR/PP interface [polypeptide binding]; other site 573370006646 dimer interface [polypeptide binding]; other site 573370006647 TPP binding site [chemical binding]; other site 573370006648 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 573370006649 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 573370006650 Outer membrane lipoprotein LolB; Region: LolB; cl19307 573370006651 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370006652 binding surface 573370006653 Tetratricopeptide repeat; Region: TPR_16; pfam13432 573370006654 TPR motif; other site 573370006655 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 573370006656 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370006657 TPR motif; other site 573370006658 TPR repeat; Region: TPR_11; pfam13414 573370006659 binding surface 573370006660 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370006661 binding surface 573370006662 TPR motif; other site 573370006663 TPR repeat; Region: TPR_11; pfam13414 573370006664 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 573370006665 alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392 573370006666 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573370006667 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 573370006668 DNA binding residues [nucleotide binding] 573370006669 Homocysteine S-methyltransferase; Region: S-methyl_trans; cl14105 573370006670 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 573370006671 substrate binding pocket [chemical binding]; other site 573370006672 dimer interface [polypeptide binding]; other site 573370006673 inhibitor binding site; inhibition site 573370006674 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 573370006675 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 573370006676 B12 binding site [chemical binding]; other site 573370006677 cobalt ligand [ion binding]; other site 573370006678 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 573370006679 catalytic residues [active] 573370006680 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573370006681 Coenzyme A binding pocket [chemical binding]; other site 573370006682 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573370006683 active site 573370006684 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 573370006685 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 573370006686 DNA repair protein RadA; Provisional; Region: PRK11823 573370006687 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 573370006688 Walker A motif; other site 573370006689 ATP binding site [chemical binding]; other site 573370006690 Walker B motif; other site 573370006691 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 573370006692 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370006693 S-adenosylmethionine binding site [chemical binding]; other site 573370006694 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 573370006695 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 573370006696 active site clefts [active] 573370006697 zinc binding site [ion binding]; other site 573370006698 dimer interface [polypeptide binding]; other site 573370006699 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 573370006700 transmembrane helices; other site 573370006701 diaminopimelate decarboxylase; Region: lysA; TIGR01048 573370006702 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 573370006703 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 573370006704 catalytic residue [active] 573370006705 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370006706 TPR motif; other site 573370006707 TPR repeat; Region: TPR_11; pfam13414 573370006708 binding surface 573370006709 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 573370006710 Ca2+ binding site [ion binding]; other site 573370006711 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 573370006712 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573370006713 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 573370006714 active site 573370006715 substrate binding site [chemical binding]; other site 573370006716 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 573370006717 FMN binding site [chemical binding]; other site 573370006718 putative catalytic residues [active] 573370006719 amphi-Trp domain; Region: amphi-Trp; TIGR04354 573370006720 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 573370006721 active site 573370006722 catalytic triad [active] 573370006723 oxyanion hole [active] 573370006724 diaminopimelate decarboxylase; Region: lysA; TIGR01048 573370006725 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 573370006726 active site 573370006727 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 573370006728 substrate binding site [chemical binding]; other site 573370006729 catalytic residues [active] 573370006730 dimer interface [polypeptide binding]; other site 573370006731 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 573370006732 MutS domain I; Region: MutS_I; pfam01624 573370006733 MutS domain II; Region: MutS_II; pfam05188 573370006734 MutS domain III; Region: MutS_III; pfam05192 573370006735 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 573370006736 Walker A/P-loop; other site 573370006737 ATP binding site [chemical binding]; other site 573370006738 Q-loop/lid; other site 573370006739 ABC transporter signature motif; other site 573370006740 Walker B; other site 573370006741 D-loop; other site 573370006742 H-loop/switch region; other site 573370006743 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 573370006744 nucleotide binding site/active site [active] 573370006745 HIT family signature motif; other site 573370006746 catalytic residue [active] 573370006747 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 573370006748 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14666 573370006749 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 573370006750 GIY-YIG motif/motif A; other site 573370006751 active site 573370006752 catalytic site [active] 573370006753 putative DNA binding site [nucleotide binding]; other site 573370006754 metal binding site [ion binding]; metal-binding site 573370006755 UvrB/uvrC motif; Region: UVR; pfam02151 573370006756 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 573370006757 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 573370006758 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370006759 S-adenosylmethionine binding site [chemical binding]; other site 573370006760 conserved hypothetical protein; Region: TIGR03833 573370006761 Protein of unknown function, DUF488; Region: DUF488; cl01246 573370006762 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 573370006763 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 573370006764 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 573370006765 HSP70 interaction site [polypeptide binding]; other site 573370006766 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 573370006767 dimer interface [polypeptide binding]; other site 573370006768 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 573370006769 CoA binding domain; Region: CoA_binding; cl17356 573370006770 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 573370006771 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573370006772 FeS/SAM binding site; other site 573370006773 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 573370006774 EamA-like transporter family; Region: EamA; pfam00892 573370006775 EamA-like transporter family; Region: EamA; pfam00892 573370006776 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 573370006777 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 573370006778 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 573370006779 active site 573370006780 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 573370006781 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 573370006782 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258 573370006783 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 573370006784 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 573370006785 putative metal binding site [ion binding]; other site 573370006786 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 573370006787 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 573370006788 Walker A/P-loop; other site 573370006789 ATP binding site [chemical binding]; other site 573370006790 Q-loop/lid; other site 573370006791 ABC transporter signature motif; other site 573370006792 Walker B; other site 573370006793 D-loop; other site 573370006794 H-loop/switch region; other site 573370006795 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 573370006796 ABC-ATPase subunit interface; other site 573370006797 dimer interface [polypeptide binding]; other site 573370006798 putative PBP binding regions; other site 573370006799 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 573370006800 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 573370006801 heme-binding residues [chemical binding]; other site 573370006802 FOG: CBS domain [General function prediction only]; Region: COG0517 573370006803 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 573370006804 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370006805 S-adenosylmethionine binding site [chemical binding]; other site 573370006806 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 573370006807 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 573370006808 Walker A motif; other site 573370006809 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 573370006810 Septum formation initiator; Region: DivIC; pfam04977 573370006811 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370006812 TPR motif; other site 573370006813 binding surface 573370006814 Tetratricopeptide repeat; Region: TPR_19; pfam14559 573370006815 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 573370006816 AMP binding site [chemical binding]; other site 573370006817 metal binding site [ion binding]; metal-binding site 573370006818 active site 573370006819 UGMP family protein; Validated; Region: PRK09604 573370006820 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 573370006821 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 573370006822 catalytic residues [active] 573370006823 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 573370006824 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 573370006825 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573370006826 Outer membrane lipoprotein; Region: YfiO; pfam13525 573370006827 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 573370006828 elongation factor G; Reviewed; Region: PRK12740 573370006829 G1 box; other site 573370006830 putative GEF interaction site [polypeptide binding]; other site 573370006831 GTP/Mg2+ binding site [chemical binding]; other site 573370006832 Switch I region; other site 573370006833 G2 box; other site 573370006834 G3 box; other site 573370006835 Switch II region; other site 573370006836 G4 box; other site 573370006837 G5 box; other site 573370006838 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 573370006839 Elongation Factor G, domain II; Region: EFG_II; pfam14492 573370006840 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cd01680 573370006841 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 573370006842 Acyltransferase family; Region: Acyl_transf_3; pfam01757 573370006843 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370006844 S-adenosylmethionine binding site [chemical binding]; other site 573370006845 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 573370006846 active site 573370006847 (T/H)XGH motif; other site 573370006848 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 573370006849 TPR repeat; Region: TPR_11; pfam13414 573370006850 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370006851 binding surface 573370006852 TPR motif; other site 573370006853 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 573370006854 active site 573370006855 metal binding site [ion binding]; metal-binding site 573370006856 twin arginine translocase protein A; Provisional; Region: tatA; PRK14859 573370006857 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 573370006858 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573370006859 active site 573370006860 motif I; other site 573370006861 motif II; other site 573370006862 YGGT family; Region: YGGT; pfam02325 573370006863 DivIVA protein; Region: DivIVA; pfam05103 573370006864 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 573370006865 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 573370006866 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 573370006867 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 573370006868 PYR/PP interface [polypeptide binding]; other site 573370006869 dimer interface [polypeptide binding]; other site 573370006870 TPP binding site [chemical binding]; other site 573370006871 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 573370006872 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 573370006873 TPP-binding site [chemical binding]; other site 573370006874 dimer interface [polypeptide binding]; other site 573370006875 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 573370006876 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 573370006877 putative valine binding site [chemical binding]; other site 573370006878 dimer interface [polypeptide binding]; other site 573370006879 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 573370006880 ketol-acid reductoisomerase; Provisional; Region: PRK05479 573370006881 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 573370006882 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 573370006883 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 573370006884 Sel1-like repeats; Region: SEL1; smart00671 573370006885 Uncharacterized conserved protein [Function unknown]; Region: COG4095 573370006886 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573370006887 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 573370006888 Coenzyme A binding pocket [chemical binding]; other site 573370006889 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573370006890 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 573370006891 Protein of unknown function (DUF554); Region: DUF554; pfam04474 573370006892 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 573370006893 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 573370006894 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 573370006895 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 573370006896 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 573370006897 active site 573370006898 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 573370006899 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 573370006900 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 573370006901 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 573370006902 catalytic center binding site [active] 573370006903 ATP binding site [chemical binding]; other site 573370006904 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 573370006905 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573370006906 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573370006907 homodimer interface [polypeptide binding]; other site 573370006908 catalytic residue [active] 573370006909 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573370006910 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 573370006911 active site 573370006912 DNA binding site [nucleotide binding] 573370006913 Int/Topo IB signature motif; other site 573370006914 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 573370006915 DHH family; Region: DHH; pfam01368 573370006916 DHHA1 domain; Region: DHHA1; pfam02272 573370006917 FOG: CBS domain [General function prediction only]; Region: COG0517 573370006918 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 573370006919 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 573370006920 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 573370006921 active site 573370006922 NTP binding site [chemical binding]; other site 573370006923 metal binding triad [ion binding]; metal-binding site 573370006924 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 573370006925 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 573370006926 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 573370006927 histidinol dehydrogenase; Region: hisD; TIGR00069 573370006928 NAD binding site [chemical binding]; other site 573370006929 dimerization interface [polypeptide binding]; other site 573370006930 product binding site; other site 573370006931 substrate binding site [chemical binding]; other site 573370006932 zinc binding site [ion binding]; other site 573370006933 catalytic residues [active] 573370006934 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 573370006935 ATP binding site [chemical binding]; other site 573370006936 active site 573370006937 phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional; Region: PRK13959 573370006938 substrate binding site [chemical binding]; other site 573370006939 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 573370006940 active site 573370006941 oxyanion hole [active] 573370006942 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573370006943 active site 573370006944 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 573370006945 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 573370006946 active site 573370006947 catalytic tetrad [active] 573370006948 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 573370006949 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573370006950 H+ Antiporter protein; Region: 2A0121; TIGR00900 573370006951 putative substrate translocation pore; other site 573370006952 Transcriptional regulators [Transcription]; Region: MarR; COG1846 573370006953 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 573370006954 Uncharacterized conserved protein [Function unknown]; Region: COG3379 573370006955 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 573370006956 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 573370006957 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 573370006958 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 573370006959 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 573370006960 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 573370006961 Cysteine-rich domain; Region: CCG; pfam02754 573370006962 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 573370006963 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 573370006964 active site 573370006965 tetramer interface [polypeptide binding]; other site 573370006966 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573370006967 active site 573370006968 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 573370006969 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 573370006970 ATP-grasp domain; Region: ATP-grasp_4; cl17255 573370006971 Carbamoyl-phosphate synthetase large chain, oligomerization domain; Region: CPSase_L_D3; pfam02787 573370006972 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 573370006973 ATP-grasp domain; Region: ATP-grasp_4; cl17255 573370006974 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 573370006975 IMP binding site; other site 573370006976 dimer interface [polypeptide binding]; other site 573370006977 partial ornithine binding site; other site 573370006978 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 573370006979 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 573370006980 active site 573370006981 HIGH motif; other site 573370006982 KMSKS motif; other site 573370006983 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 573370006984 tRNA binding surface [nucleotide binding]; other site 573370006985 anticodon binding site; other site 573370006986 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 573370006987 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 573370006988 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 573370006989 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 573370006990 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370006991 TPR motif; other site 573370006992 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 573370006993 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 573370006994 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 573370006995 PilZ domain; Region: PilZ; pfam07238 573370006996 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 573370006997 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 573370006998 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 573370006999 Walker A/P-loop; other site 573370007000 ATP binding site [chemical binding]; other site 573370007001 Q-loop/lid; other site 573370007002 ABC transporter signature motif; other site 573370007003 Walker B; other site 573370007004 D-loop; other site 573370007005 H-loop/switch region; other site 573370007006 Cobalt transport protein; Region: CbiQ; cl00463 573370007007 cobalt transport protein CbiM; Validated; Region: PRK06265 573370007008 ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266 573370007009 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 573370007010 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 573370007011 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573370007012 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 573370007013 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 573370007014 Preprotein translocase subunit; Region: YajC; pfam02699 573370007015 Staphylococcal nuclease homologues; Region: SNc; smart00318 573370007016 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 573370007017 Catalytic site; other site 573370007018 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 573370007019 metal-binding site [ion binding] 573370007020 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 573370007021 catalytic residues [active] 573370007022 hypothetical protein; Provisional; Region: PRK11615 573370007023 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 573370007024 putative active site pocket [active] 573370007025 4-fold oligomerization interface [polypeptide binding]; other site 573370007026 metal binding residues [ion binding]; metal-binding site 573370007027 3-fold/trimer interface [polypeptide binding]; other site 573370007028 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 573370007029 GMP synthase; Reviewed; Region: guaA; PRK00074 573370007030 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 573370007031 AMP/PPi binding site [chemical binding]; other site 573370007032 candidate oxyanion hole; other site 573370007033 catalytic triad [active] 573370007034 potential glutamine specificity residues [chemical binding]; other site 573370007035 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 573370007036 ATP Binding subdomain [chemical binding]; other site 573370007037 Ligand Binding sites [chemical binding]; other site 573370007038 Dimerization subdomain; other site 573370007039 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 573370007040 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 573370007041 active site 573370007042 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 573370007043 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 573370007044 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 573370007045 Walker A/P-loop; other site 573370007046 ATP binding site [chemical binding]; other site 573370007047 Q-loop/lid; other site 573370007048 ABC transporter signature motif; other site 573370007049 Walker B; other site 573370007050 D-loop; other site 573370007051 H-loop/switch region; other site 573370007052 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 573370007053 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 573370007054 Walker A/P-loop; other site 573370007055 ATP binding site [chemical binding]; other site 573370007056 Q-loop/lid; other site 573370007057 ABC transporter signature motif; other site 573370007058 Walker B; other site 573370007059 D-loop; other site 573370007060 H-loop/switch region; other site 573370007061 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 573370007062 TM-ABC transporter signature motif; other site 573370007063 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 573370007064 TM-ABC transporter signature motif; other site 573370007065 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 573370007066 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 573370007067 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370007068 TPR motif; other site 573370007069 TPR repeat; Region: TPR_11; pfam13414 573370007070 binding surface 573370007071 TPR repeat; Region: TPR_11; pfam13414 573370007072 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 573370007073 CcmB protein; Region: CcmB; cl17444 573370007074 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 573370007075 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 573370007076 Walker A/P-loop; other site 573370007077 ATP binding site [chemical binding]; other site 573370007078 Q-loop/lid; other site 573370007079 ABC transporter signature motif; other site 573370007080 Walker B; other site 573370007081 D-loop; other site 573370007082 H-loop/switch region; other site 573370007083 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 573370007084 CcmE; Region: CcmE; cl00994 573370007085 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 573370007086 Domain of unknown function DUF21; Region: DUF21; pfam01595 573370007087 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 573370007088 DHHW protein; Region: DHHW; pfam14286 573370007089 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 573370007090 active site 573370007091 (T/H)XGH motif; other site 573370007092 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 573370007093 putative catalytic cysteine [active] 573370007094 Methyltransferase domain; Region: Methyltransf_31; pfam13847 573370007095 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370007096 S-adenosylmethionine binding site [chemical binding]; other site 573370007097 Src homology 2 (SH2) domain; Region: SH2; cl15255 573370007098 phosphotyrosine binding pocket [polypeptide binding]; other site 573370007099 hydrophobic binding pocket [polypeptide binding]; other site 573370007100 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 573370007101 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 573370007102 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 573370007103 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 573370007104 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 573370007105 ATP-grasp domain; Region: ATP-grasp_4; cl17255 573370007106 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 573370007107 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 573370007108 PAS domain; Region: PAS_9; pfam13426 573370007109 PAS domain; Region: PAS_9; pfam13426 573370007110 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370007111 putative active site [active] 573370007112 heme pocket [chemical binding]; other site 573370007113 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370007114 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 573370007115 Walker A motif; other site 573370007116 ATP binding site [chemical binding]; other site 573370007117 Walker B motif; other site 573370007118 arginine finger; other site 573370007119 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 573370007120 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 573370007121 inhibitor-cofactor binding pocket; inhibition site 573370007122 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573370007123 catalytic residue [active] 573370007124 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_6; cd06340 573370007125 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 573370007126 putative ligand binding site [chemical binding]; other site 573370007127 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 573370007128 TM-ABC transporter signature motif; other site 573370007129 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 573370007130 TM-ABC transporter signature motif; other site 573370007131 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 573370007132 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 573370007133 Walker A/P-loop; other site 573370007134 ATP binding site [chemical binding]; other site 573370007135 Q-loop/lid; other site 573370007136 ABC transporter signature motif; other site 573370007137 Walker B; other site 573370007138 D-loop; other site 573370007139 H-loop/switch region; other site 573370007140 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 573370007141 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 573370007142 Walker A/P-loop; other site 573370007143 ATP binding site [chemical binding]; other site 573370007144 Q-loop/lid; other site 573370007145 ABC transporter signature motif; other site 573370007146 Walker B; other site 573370007147 D-loop; other site 573370007148 H-loop/switch region; other site 573370007149 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 573370007150 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 573370007151 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 573370007152 FOG: CBS domain [General function prediction only]; Region: COG0517 573370007153 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 573370007154 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 573370007155 YcfA-like protein; Region: YcfA; pfam07927 573370007156 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 573370007157 MoxR-like ATPases [General function prediction only]; Region: COG0714 573370007158 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370007159 Walker A motif; other site 573370007160 ATP binding site [chemical binding]; other site 573370007161 Walker B motif; other site 573370007162 arginine finger; other site 573370007163 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864 573370007164 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 573370007165 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 573370007166 metal ion-dependent adhesion site (MIDAS); other site 573370007167 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 573370007168 Ligand Binding Site [chemical binding]; other site 573370007169 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573370007170 short chain dehydrogenase; Provisional; Region: PRK12937 573370007171 NAD(P) binding site [chemical binding]; other site 573370007172 active site 573370007173 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 573370007174 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 573370007175 HAMP domain; Region: HAMP; pfam00672 573370007176 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370007177 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 573370007178 dimer interface [polypeptide binding]; other site 573370007179 putative CheW interface [polypeptide binding]; other site 573370007180 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 573370007181 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 573370007182 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; smart00790 573370007183 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 573370007184 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 573370007185 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 573370007186 active site 573370007187 dimer interface [polypeptide binding]; other site 573370007188 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 573370007189 dimer interface [polypeptide binding]; other site 573370007190 active site 573370007191 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 573370007192 glycogen branching enzyme; Provisional; Region: PRK12313 573370007193 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 573370007194 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 573370007195 active site 573370007196 catalytic site [active] 573370007197 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 573370007198 glycogen synthase; Provisional; Region: glgA; PRK00654 573370007199 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 573370007200 ADP-binding pocket [chemical binding]; other site 573370007201 homodimer interface [polypeptide binding]; other site 573370007202 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 573370007203 nudix motif; other site 573370007204 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573370007205 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 573370007206 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 573370007207 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 573370007208 active site 573370007209 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 573370007210 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 573370007211 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 573370007212 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 573370007213 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 573370007214 Walker A/P-loop; other site 573370007215 ATP binding site [chemical binding]; other site 573370007216 Q-loop/lid; other site 573370007217 ABC transporter signature motif; other site 573370007218 Walker B; other site 573370007219 D-loop; other site 573370007220 H-loop/switch region; other site 573370007221 HlyD family secretion protein; Region: HlyD; pfam00529 573370007222 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 573370007223 HlyD family secretion protein; Region: HlyD_3; pfam13437 573370007224 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573370007225 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573370007226 Permease; Region: Permease; pfam02405 573370007227 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 573370007228 mce related protein; Region: MCE; pfam02470 573370007229 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 573370007230 VacJ like lipoprotein; Region: VacJ; cl01073 573370007231 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 573370007232 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 573370007233 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573370007234 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 573370007235 EamA-like transporter family; Region: EamA; pfam00892 573370007236 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 573370007237 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 573370007238 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 573370007239 Ferredoxin [Energy production and conversion]; Region: COG1146 573370007240 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 573370007241 Nitroreductase [Energy production and conversion]; Region: NfnB; COG0778 573370007242 FMN binding site [chemical binding]; other site 573370007243 dimer interface [polypeptide binding]; other site 573370007244 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 573370007245 NlpC/P60 family; Region: NLPC_P60; pfam00877 573370007246 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 573370007247 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370007248 putative active site [active] 573370007249 heme pocket [chemical binding]; other site 573370007250 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370007251 dimer interface [polypeptide binding]; other site 573370007252 phosphorylation site [posttranslational modification] 573370007253 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370007254 ATP binding site [chemical binding]; other site 573370007255 Mg2+ binding site [ion binding]; other site 573370007256 G-X-G motif; other site 573370007257 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 573370007258 Thioredoxin; Region: Thioredoxin_4; pfam13462 573370007259 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 573370007260 active site residue [active] 573370007261 Predicted integral membrane protein [Function unknown]; Region: COG5542 573370007262 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573370007263 active site 573370007264 Protein of unknown function, DUF547; Region: DUF547; pfam04784 573370007265 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 573370007266 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 573370007267 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 573370007268 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370007269 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573370007270 putative active site [active] 573370007271 heme pocket [chemical binding]; other site 573370007272 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370007273 dimer interface [polypeptide binding]; other site 573370007274 phosphorylation site [posttranslational modification] 573370007275 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370007276 ATP binding site [chemical binding]; other site 573370007277 Mg2+ binding site [ion binding]; other site 573370007278 G-X-G motif; other site 573370007279 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370007280 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370007281 active site 573370007282 phosphorylation site [posttranslational modification] 573370007283 intermolecular recognition site; other site 573370007284 dimerization interface [polypeptide binding]; other site 573370007285 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 573370007286 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 573370007287 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 573370007288 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 573370007289 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 573370007290 substrate binding site; other site 573370007291 dimer interface; other site 573370007292 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 573370007293 homotrimer interaction site [polypeptide binding]; other site 573370007294 zinc binding site [ion binding]; other site 573370007295 CDP-binding sites; other site 573370007296 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 573370007297 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 573370007298 active site 573370007299 HIGH motif; other site 573370007300 KMSKS motif; other site 573370007301 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 573370007302 tRNA binding surface [nucleotide binding]; other site 573370007303 anticodon binding site; other site 573370007304 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 573370007305 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 573370007306 putative catalytic site [active] 573370007307 putative metal binding site [ion binding]; other site 573370007308 putative phosphate binding site [ion binding]; other site 573370007309 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370007310 active site 573370007311 phosphorylation site [posttranslational modification] 573370007312 intermolecular recognition site; other site 573370007313 dimerization interface [polypeptide binding]; other site 573370007314 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 573370007315 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370007316 active site 573370007317 phosphorylation site [posttranslational modification] 573370007318 intermolecular recognition site; other site 573370007319 dimerization interface [polypeptide binding]; other site 573370007320 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573370007321 Zn2+ binding site [ion binding]; other site 573370007322 Mg2+ binding site [ion binding]; other site 573370007323 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 573370007324 active site 573370007325 metal binding site [ion binding]; metal-binding site 573370007326 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 573370007327 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 573370007328 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 573370007329 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370007330 active site 573370007331 phosphorylation site [posttranslational modification] 573370007332 intermolecular recognition site; other site 573370007333 dimerization interface [polypeptide binding]; other site 573370007334 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370007335 PAS domain; Region: PAS_9; pfam13426 573370007336 putative active site [active] 573370007337 heme pocket [chemical binding]; other site 573370007338 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573370007339 Zn2+ binding site [ion binding]; other site 573370007340 Mg2+ binding site [ion binding]; other site 573370007341 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 573370007342 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 573370007343 putative NAD(P) binding site [chemical binding]; other site 573370007344 putative active site [active] 573370007345 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 573370007346 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 573370007347 alkyl hydroperoxide reductase subunit F; Region: AhpF; TIGR03140 573370007348 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; cl17726 573370007349 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 573370007350 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 573370007351 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 573370007352 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 573370007353 active site 573370007354 HIGH motif; other site 573370007355 KMSK motif region; other site 573370007356 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 573370007357 tRNA binding surface [nucleotide binding]; other site 573370007358 anticodon binding site; other site 573370007359 Sporulation related domain; Region: SPOR; pfam05036 573370007360 pyruvoyl-dependent arginine decarboxylase; Reviewed; Region: PRK01285 573370007361 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 573370007362 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 573370007363 minor groove reading motif; other site 573370007364 helix-hairpin-helix signature motif; other site 573370007365 substrate binding pocket [chemical binding]; other site 573370007366 active site 573370007367 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 573370007368 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573370007369 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573370007370 putative substrate translocation pore; other site 573370007371 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 573370007372 Transposase domain (DUF772); Region: DUF772; pfam05598 573370007373 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573370007374 AAA ATPase domain; Region: AAA_15; pfam13175 573370007375 AAA domain; Region: AAA_23; pfam13476 573370007376 Walker A/P-loop; other site 573370007377 ATP binding site [chemical binding]; other site 573370007378 Trehalase; Region: Trehalase; cl17346 573370007379 AAA domain; Region: AAA_21; pfam13304 573370007380 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 573370007381 active site 573370007382 metal binding site [ion binding]; metal-binding site 573370007383 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 573370007384 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 573370007385 CPxP motif; other site 573370007386 DsrE/DsrF-like family; Region: DrsE; pfam02635 573370007387 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 573370007388 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 573370007389 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370007390 ATP binding site [chemical binding]; other site 573370007391 Mg2+ binding site [ion binding]; other site 573370007392 G-X-G motif; other site 573370007393 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 573370007394 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 573370007395 RNA binding surface [nucleotide binding]; other site 573370007396 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 573370007397 active site 573370007398 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 573370007399 TAP-like protein; Region: Abhydrolase_4; pfam08386 573370007400 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 573370007401 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 573370007402 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 573370007403 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 573370007404 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 573370007405 Walker A/P-loop; other site 573370007406 ATP binding site [chemical binding]; other site 573370007407 Q-loop/lid; other site 573370007408 ABC transporter signature motif; other site 573370007409 Walker B; other site 573370007410 D-loop; other site 573370007411 H-loop/switch region; other site 573370007412 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370007413 active site 573370007414 phosphorylation site [posttranslational modification] 573370007415 intermolecular recognition site; other site 573370007416 dimerization interface [polypeptide binding]; other site 573370007417 Acyltransferase family; Region: Acyl_transf_3; pfam01757 573370007418 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 573370007419 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573370007420 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370007421 active site 573370007422 phosphorylation site [posttranslational modification] 573370007423 intermolecular recognition site; other site 573370007424 dimerization interface [polypeptide binding]; other site 573370007425 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573370007426 DNA binding residues [nucleotide binding] 573370007427 dimerization interface [polypeptide binding]; other site 573370007428 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 573370007429 Histidine kinase; Region: HisKA_3; pfam07730 573370007430 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370007431 ATP binding site [chemical binding]; other site 573370007432 Mg2+ binding site [ion binding]; other site 573370007433 G-X-G motif; other site 573370007434 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573370007435 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 573370007436 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 573370007437 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 573370007438 catalytic residues [active] 573370007439 Domain of unknown function (DUF362); Region: DUF362; pfam04015 573370007440 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 573370007441 Acylphosphatase; Region: Acylphosphatase; pfam00708 573370007442 HypF finger; Region: zf-HYPF; pfam07503 573370007443 HypF finger; Region: zf-HYPF; pfam07503 573370007444 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 573370007445 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 573370007446 Predicted transcriptional regulator [Transcription]; Region: COG2932 573370007447 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 573370007448 Catalytic site [active] 573370007449 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 573370007450 Predicted transcriptional regulator [Transcription]; Region: COG2932 573370007451 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 573370007452 Catalytic site [active] 573370007453 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 573370007454 Predicted transcriptional regulator [Transcription]; Region: COG2932 573370007455 Catalytic site [active] 573370007456 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 573370007457 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 573370007458 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 573370007459 RNA binding surface [nucleotide binding]; other site 573370007460 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 573370007461 active site 573370007462 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 573370007463 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 573370007464 CoA-binding site [chemical binding]; other site 573370007465 ATP-binding [chemical binding]; other site 573370007466 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR_like; cd08242 573370007467 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 573370007468 putative NAD(P) binding site [chemical binding]; other site 573370007469 catalytic Zn binding site [ion binding]; other site 573370007470 structural Zn binding site [ion binding]; other site 573370007471 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 573370007472 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 573370007473 nucleotide binding pocket [chemical binding]; other site 573370007474 K-X-D-G motif; other site 573370007475 catalytic site [active] 573370007476 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 573370007477 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 573370007478 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 573370007479 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 573370007480 Dimer interface [polypeptide binding]; other site 573370007481 Protein of unknown function (DUF3431); Region: DUF3431; pfam11913 573370007482 Ion channel; Region: Ion_trans_2; pfam07885 573370007483 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 573370007484 TrkA-N domain; Region: TrkA_N; pfam02254 573370007485 TrkA-C domain; Region: TrkA_C; pfam02080 573370007486 excinuclease ABC subunit B; Provisional; Region: PRK05298 573370007487 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573370007488 ATP binding site [chemical binding]; other site 573370007489 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573370007490 nucleotide binding region [chemical binding]; other site 573370007491 ATP-binding site [chemical binding]; other site 573370007492 Ultra-violet resistance protein B; Region: UvrB; pfam12344 573370007493 UvrB/uvrC motif; Region: UVR; pfam02151 573370007494 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 573370007495 YcfA-like protein; Region: YcfA; pfam07927 573370007496 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 573370007497 HicB family; Region: HicB; pfam05534 573370007498 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 573370007499 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 573370007500 Clp amino terminal domain; Region: Clp_N; pfam02861 573370007501 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370007502 Walker A motif; other site 573370007503 ATP binding site [chemical binding]; other site 573370007504 Walker B motif; other site 573370007505 arginine finger; other site 573370007506 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370007507 Walker A motif; other site 573370007508 ATP binding site [chemical binding]; other site 573370007509 Walker B motif; other site 573370007510 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 573370007511 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 573370007512 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 573370007513 putative active site [active] 573370007514 putative metal binding residues [ion binding]; other site 573370007515 signature motif; other site 573370007516 putative triphosphate binding site [ion binding]; other site 573370007517 dimer interface [polypeptide binding]; other site 573370007518 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 573370007519 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370007520 active site 573370007521 phosphorylation site [posttranslational modification] 573370007522 intermolecular recognition site; other site 573370007523 dimerization interface [polypeptide binding]; other site 573370007524 CheB methylesterase; Region: CheB_methylest; pfam01339 573370007525 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 573370007526 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 573370007527 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 573370007528 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 573370007529 putative CheA interaction surface; other site 573370007530 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 573370007531 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 573370007532 putative binding surface; other site 573370007533 active site 573370007534 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 573370007535 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370007536 ATP binding site [chemical binding]; other site 573370007537 Mg2+ binding site [ion binding]; other site 573370007538 G-X-G motif; other site 573370007539 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 573370007540 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 573370007541 dimer interface [polypeptide binding]; other site 573370007542 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 573370007543 putative CheW interface [polypeptide binding]; other site 573370007544 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 573370007545 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 573370007546 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370007547 putative active site [active] 573370007548 heme pocket [chemical binding]; other site 573370007549 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370007550 dimer interface [polypeptide binding]; other site 573370007551 phosphorylation site [posttranslational modification] 573370007552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370007553 ATP binding site [chemical binding]; other site 573370007554 Mg2+ binding site [ion binding]; other site 573370007555 G-X-G motif; other site 573370007556 CheD chemotactic sensory transduction; Region: CheD; cl00810 573370007557 HDOD domain; Region: HDOD; pfam08668 573370007558 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 573370007559 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 573370007560 Ligand Binding Site [chemical binding]; other site 573370007561 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 573370007562 Peptidase family M23; Region: Peptidase_M23; pfam01551 573370007563 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 573370007564 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 573370007565 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 573370007566 flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499 573370007567 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 573370007568 GTP/Mg2+ binding site [chemical binding]; other site 573370007569 G5 box; other site 573370007570 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370007571 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK06731 573370007572 G1 box; other site 573370007573 Walker A motif; other site 573370007574 ATP binding site [chemical binding]; other site 573370007575 Walker B motif; other site 573370007576 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 573370007577 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 573370007578 P-loop; other site 573370007579 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 573370007580 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573370007581 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573370007582 DNA binding residues [nucleotide binding] 573370007583 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370007584 active site 573370007585 phosphorylation site [posttranslational modification] 573370007586 intermolecular recognition site; other site 573370007587 dimerization interface [polypeptide binding]; other site 573370007588 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 573370007589 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl19192 573370007590 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 573370007591 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 573370007592 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 573370007593 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 573370007594 elongation factor P; Validated; Region: PRK00529 573370007595 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 573370007596 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 573370007597 RNA binding site [nucleotide binding]; other site 573370007598 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 573370007599 RNA binding site [nucleotide binding]; other site 573370007600 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 573370007601 trimer interface [polypeptide binding]; other site 573370007602 active site 573370007603 dimer interface [polypeptide binding]; other site 573370007604 Predicted GTPase [General function prediction only]; Region: COG0218 573370007605 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 573370007606 G1 box; other site 573370007607 GTP/Mg2+ binding site [chemical binding]; other site 573370007608 Switch I region; other site 573370007609 G2 box; other site 573370007610 G3 box; other site 573370007611 Switch II region; other site 573370007612 G4 box; other site 573370007613 G5 box; other site 573370007614 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 573370007615 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 573370007616 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573370007617 active site 573370007618 DNA binding site [nucleotide binding] 573370007619 Int/Topo IB signature motif; other site 573370007620 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 573370007621 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 573370007622 catalytic residues [active] 573370007623 catalytic nucleophile [active] 573370007624 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; cl19880 573370007625 AAA domain; Region: AAA_25; pfam13481 573370007626 Walker A motif; other site 573370007627 ATP binding site [chemical binding]; other site 573370007628 Walker B motif; other site 573370007629 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 573370007630 KilA-N domain; Region: KilA-N; pfam04383 573370007631 DsrE/DsrF-like family; Region: DrsE; pfam02635 573370007632 YCII-related domain; Region: YCII; cl00999 573370007633 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 573370007634 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 573370007635 ligand binding site [chemical binding]; other site 573370007636 flexible hinge region; other site 573370007637 PAS domain; Region: PAS_9; pfam13426 573370007638 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370007639 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573370007640 dimer interface [polypeptide binding]; other site 573370007641 putative CheW interface [polypeptide binding]; other site 573370007642 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 573370007643 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 573370007644 active site 573370007645 nucleotide binding site [chemical binding]; other site 573370007646 HIGH motif; other site 573370007647 KMSKS motif; other site 573370007648 Autotransporter beta-domain; Region: Autotransporter; pfam03797 573370007649 FecR protein; Region: FecR; pfam04773 573370007650 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 573370007651 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 573370007652 Radical SAM superfamily; Region: Radical_SAM; pfam04055 573370007653 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573370007654 FeS/SAM binding site; other site 573370007655 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 573370007656 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 573370007657 P-loop; other site 573370007658 Magnesium ion binding site [ion binding]; other site 573370007659 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003 573370007660 amphi-Trp domain; Region: amphi-Trp; TIGR04354 573370007661 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 573370007662 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 573370007663 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573370007664 motif II; other site 573370007665 Phosphotransferase enzyme family; Region: APH; pfam01636 573370007666 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 573370007667 Deoxyhypusine synthase; Region: DS; cl00826 573370007668 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 573370007669 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 573370007670 active site 573370007671 catalytic site [active] 573370007672 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 573370007673 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 573370007674 TPP-binding site; other site 573370007675 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 573370007676 PYR/PP interface [polypeptide binding]; other site 573370007677 dimer interface [polypeptide binding]; other site 573370007678 TPP binding site [chemical binding]; other site 573370007679 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 573370007680 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 573370007681 putative FMN binding site [chemical binding]; other site 573370007682 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 573370007683 substrate binding pocket [chemical binding]; other site 573370007684 chain length determination region; other site 573370007685 active site lid residues [active] 573370007686 substrate-Mg2+ binding site; other site 573370007687 catalytic residues [active] 573370007688 aspartate-rich region 1; other site 573370007689 aspartate-rich region 2; other site 573370007690 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 573370007691 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 573370007692 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 573370007693 generic binding surface II; other site 573370007694 generic binding surface I; other site 573370007695 prolyl-tRNA synthetase; Provisional; Region: PRK09194 573370007696 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 573370007697 dimer interface [polypeptide binding]; other site 573370007698 motif 1; other site 573370007699 active site 573370007700 motif 2; other site 573370007701 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 573370007702 putative deacylase active site [active] 573370007703 motif 3; other site 573370007704 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 573370007705 anticodon binding site; other site 573370007706 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 573370007707 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 573370007708 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 573370007709 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370007710 active site 573370007711 phosphorylation site [posttranslational modification] 573370007712 intermolecular recognition site; other site 573370007713 dimerization interface [polypeptide binding]; other site 573370007714 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction mechanisms]; Region: SpoIIAA; COG1366 573370007715 HAMP domain; Region: HAMP; pfam00672 573370007716 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 573370007717 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370007718 putative active site [active] 573370007719 heme pocket [chemical binding]; other site 573370007720 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370007721 dimer interface [polypeptide binding]; other site 573370007722 phosphorylation site [posttranslational modification] 573370007723 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370007724 ATP binding site [chemical binding]; other site 573370007725 Mg2+ binding site [ion binding]; other site 573370007726 G-X-G motif; other site 573370007727 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 573370007728 putative ligand binding site [chemical binding]; other site 573370007729 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 573370007730 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 573370007731 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 573370007732 molybdopterin cofactor binding site; other site 573370007733 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 573370007734 molybdopterin cofactor binding site; other site 573370007735 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 573370007736 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 573370007737 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 573370007738 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 573370007739 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573370007740 FeS/SAM binding site; other site 573370007741 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 573370007742 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 573370007743 GTP binding site; other site 573370007744 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 573370007745 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 573370007746 putative transporter; Validated; Region: PRK03818 573370007747 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 573370007748 TrkA-C domain; Region: TrkA_C; pfam02080 573370007749 TrkA-C domain; Region: TrkA_C; pfam02080 573370007750 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 573370007751 Peptidase family M48; Region: Peptidase_M48; pfam01435 573370007752 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370007753 S-adenosylmethionine binding site [chemical binding]; other site 573370007754 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 573370007755 EamA-like transporter family; Region: EamA; pfam00892 573370007756 EamA-like transporter family; Region: EamA; pfam00892 573370007757 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 573370007758 ligand binding site; other site 573370007759 tetramer interface; other site 573370007760 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 573370007761 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573370007762 FeS/SAM binding site; other site 573370007763 Iron-sulfur cluster-binding domain; Region: SPASM; pfam13186 573370007764 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 573370007765 NeuB family; Region: NeuB; pfam03102 573370007766 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 573370007767 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 573370007768 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 573370007769 active site 573370007770 catalytic residues [active] 573370007771 metal binding site [ion binding]; metal-binding site 573370007772 Methyltransferase domain; Region: Methyltransf_12; pfam08242 573370007773 Amidohydrolase; Region: Amidohydro_2; pfam04909 573370007774 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 573370007775 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 573370007776 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 573370007777 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573370007778 motif II; other site 573370007779 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573370007780 PAS domain S-box; Region: sensory_box; TIGR00229 573370007781 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370007782 putative active site [active] 573370007783 heme pocket [chemical binding]; other site 573370007784 PAS fold; Region: PAS_4; pfam08448 573370007785 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370007786 putative active site [active] 573370007787 heme pocket [chemical binding]; other site 573370007788 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 573370007789 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370007790 putative active site [active] 573370007791 heme pocket [chemical binding]; other site 573370007792 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370007793 dimer interface [polypeptide binding]; other site 573370007794 phosphorylation site [posttranslational modification] 573370007795 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370007796 ATP binding site [chemical binding]; other site 573370007797 Mg2+ binding site [ion binding]; other site 573370007798 G-X-G motif; other site 573370007799 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370007800 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370007801 active site 573370007802 phosphorylation site [posttranslational modification] 573370007803 intermolecular recognition site; other site 573370007804 dimerization interface [polypeptide binding]; other site 573370007805 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 573370007806 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 573370007807 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573370007808 active site 573370007809 DNA binding site [nucleotide binding] 573370007810 Int/Topo IB signature motif; other site 573370007811 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573370007812 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573370007813 non-specific DNA binding site [nucleotide binding]; other site 573370007814 salt bridge; other site 573370007815 sequence-specific DNA binding site [nucleotide binding]; other site 573370007816 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573370007817 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573370007818 non-specific DNA binding site [nucleotide binding]; other site 573370007819 salt bridge; other site 573370007820 sequence-specific DNA binding site [nucleotide binding]; other site 573370007821 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573370007822 active site 573370007823 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 573370007824 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 573370007825 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 573370007826 nucleotide binding site/active site [active] 573370007827 HIT family signature motif; other site 573370007828 catalytic residue [active] 573370007829 Domain of unknown function (DUF4268); Region: DUF4268; pfam14088 573370007830 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 573370007831 active site 573370007832 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 573370007833 nucleotide binding site/active site [active] 573370007834 HIT family signature motif; other site 573370007835 catalytic residue [active] 573370007836 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 573370007837 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370007838 active site 573370007839 phosphorylation site [posttranslational modification] 573370007840 intermolecular recognition site; other site 573370007841 dimerization interface [polypeptide binding]; other site 573370007842 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573370007843 Zn2+ binding site [ion binding]; other site 573370007844 Mg2+ binding site [ion binding]; other site 573370007845 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370007846 active site 573370007847 phosphorylation site [posttranslational modification] 573370007848 intermolecular recognition site; other site 573370007849 dimerization interface [polypeptide binding]; other site 573370007850 PAS domain S-box; Region: sensory_box; TIGR00229 573370007851 PAS domain; Region: PAS; smart00091 573370007852 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573370007853 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370007854 dimer interface [polypeptide binding]; other site 573370007855 phosphorylation site [posttranslational modification] 573370007856 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370007857 ATP binding site [chemical binding]; other site 573370007858 Mg2+ binding site [ion binding]; other site 573370007859 G-X-G motif; other site 573370007860 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 573370007861 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370007862 active site 573370007863 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 573370007864 phosphorylation site [posttranslational modification] 573370007865 intermolecular recognition site; other site 573370007866 dimerization interface [polypeptide binding]; other site 573370007867 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370007868 metal binding site [ion binding]; metal-binding site 573370007869 active site 573370007870 I-site; other site 573370007871 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573370007872 non-specific DNA binding site [nucleotide binding]; other site 573370007873 salt bridge; other site 573370007874 sequence-specific DNA binding site [nucleotide binding]; other site 573370007875 Protein of unknown function (DUF3622); Region: DUF3622; pfam12286 573370007876 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951 573370007877 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 573370007878 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 573370007879 hypothetical protein; Region: PHA00669 573370007880 Holin family; Region: Phage_holin_4; cl01989 573370007881 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 573370007882 active site 573370007883 nucleophile elbow; other site 573370007884 Protein of unknown function (DUF3380); Region: DUF3380; pfam11860 573370007885 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 573370007886 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 573370007887 N-acetyl-D-glucosamine binding site [chemical binding]; other site 573370007888 Phage terminase large subunit (GpA); Region: Terminase_GpA; cl19377 573370007889 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573370007890 active site 573370007891 DNA binding site [nucleotide binding] 573370007892 Int/Topo IB signature motif; other site 573370007893 replicative DNA helicase; Region: DnaB; TIGR00665 573370007894 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 573370007895 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 573370007896 Walker A motif; other site 573370007897 ATP binding site [chemical binding]; other site 573370007898 Walker B motif; other site 573370007899 DNA binding loops [nucleotide binding] 573370007900 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 573370007901 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573370007902 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573370007903 non-specific DNA binding site [nucleotide binding]; other site 573370007904 salt bridge; other site 573370007905 sequence-specific DNA binding site [nucleotide binding]; other site 573370007906 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573370007907 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573370007908 non-specific DNA binding site [nucleotide binding]; other site 573370007909 salt bridge; other site 573370007910 sequence-specific DNA binding site [nucleotide binding]; other site 573370007911 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 573370007912 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 573370007913 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 573370007914 dimer interface [polypeptide binding]; other site 573370007915 substrate binding site [chemical binding]; other site 573370007916 ATP binding site [chemical binding]; other site 573370007917 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 573370007918 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 573370007919 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 573370007920 Helix-hairpin-helix containing domain; Region: HHH_4; pfam14490 573370007921 AAA domain; Region: AAA_30; pfam13604 573370007922 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 573370007923 Helix-hairpin-helix domain; Region: HHH_8; pfam14716 573370007924 recombination protein RecR; Reviewed; Region: recR; PRK00076 573370007925 RecR protein; Region: RecR; pfam02132 573370007926 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 573370007927 putative active site [active] 573370007928 putative metal-binding site [ion binding]; other site 573370007929 tetramer interface [polypeptide binding]; other site 573370007930 hypothetical protein; Validated; Region: PRK00153 573370007931 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14959 573370007932 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370007933 Walker A motif; other site 573370007934 ATP binding site [chemical binding]; other site 573370007935 Walker B motif; other site 573370007936 arginine finger; other site 573370007937 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 573370007938 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 573370007939 homodimer interface [polypeptide binding]; other site 573370007940 substrate-cofactor binding pocket; other site 573370007941 catalytic residue [active] 573370007942 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 573370007943 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370007944 dimerization interface [polypeptide binding]; other site 573370007945 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370007946 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 573370007947 dimer interface [polypeptide binding]; other site 573370007948 putative CheW interface [polypeptide binding]; other site 573370007949 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370007950 binding surface 573370007951 TPR motif; other site 573370007952 TPR repeat; Region: TPR_11; pfam13414 573370007953 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 573370007954 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573370007955 Zn2+ binding site [ion binding]; other site 573370007956 Mg2+ binding site [ion binding]; other site 573370007957 adenylate cyclase; Provisional; Region: cyaA; PRK09450 573370007958 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 573370007959 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 573370007960 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 573370007961 phosphoglucomutase; Validated; Region: PRK07564 573370007962 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 573370007963 active site 573370007964 substrate binding site [chemical binding]; other site 573370007965 metal binding site [ion binding]; metal-binding site 573370007966 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 573370007967 Peptidase family M50; Region: Peptidase_M50; pfam02163 573370007968 active site 573370007969 putative substrate binding region [chemical binding]; other site 573370007970 phosphoglyceromutase; Provisional; Region: PRK05434 573370007971 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 573370007972 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 573370007973 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 573370007974 acyl-activating enzyme (AAE) consensus motif; other site 573370007975 AMP binding site [chemical binding]; other site 573370007976 active site 573370007977 CoA binding site [chemical binding]; other site 573370007978 ACT domain-containing protein [General function prediction only]; Region: COG4747 573370007979 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 573370007980 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 573370007981 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 573370007982 tRNA-splicing ligase RtcB; Region: RtcB; pfam01139 573370007983 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 573370007984 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370007985 dimer interface [polypeptide binding]; other site 573370007986 phosphorylation site [posttranslational modification] 573370007987 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370007988 ATP binding site [chemical binding]; other site 573370007989 Mg2+ binding site [ion binding]; other site 573370007990 G-X-G motif; other site 573370007991 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370007992 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370007993 active site 573370007994 phosphorylation site [posttranslational modification] 573370007995 intermolecular recognition site; other site 573370007996 dimerization interface [polypeptide binding]; other site 573370007997 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 573370007998 putative binding surface; other site 573370007999 active site 573370008000 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 573370008001 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 573370008002 oligomerization interface [polypeptide binding]; other site 573370008003 active site 573370008004 metal binding site [ion binding]; metal-binding site 573370008005 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078 573370008006 active site 573370008007 phosphorylation site [posttranslational modification] 573370008008 intermolecular recognition site; other site 573370008009 dimerization interface [polypeptide binding]; other site 573370008010 TPR repeat; Region: TPR_11; pfam13414 573370008011 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370008012 binding surface 573370008013 Tetratricopeptide repeat; Region: TPR_16; pfam13432 573370008014 TPR motif; other site 573370008015 TPR repeat; Region: TPR_11; pfam13414 573370008016 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370008017 binding surface 573370008018 TPR motif; other site 573370008019 TPR repeat; Region: TPR_11; pfam13414 573370008020 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 573370008021 Glutamine cyclotransferase; Region: Glu_cyclase_2; cl19848 573370008022 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370008023 PAS domain; Region: PAS_9; pfam13426 573370008024 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 573370008025 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370008026 Walker A motif; other site 573370008027 ATP binding site [chemical binding]; other site 573370008028 Walker B motif; other site 573370008029 arginine finger; other site 573370008030 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 573370008031 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 573370008032 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 573370008033 putative active site [active] 573370008034 Protein of unknown function, DUF484; Region: DUF484; cl17449 573370008035 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370008036 metal binding site [ion binding]; metal-binding site 573370008037 active site 573370008038 I-site; other site 573370008039 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 573370008040 PAS domain; Region: PAS_9; pfam13426 573370008041 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370008042 putative active site [active] 573370008043 heme pocket [chemical binding]; other site 573370008044 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370008045 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573370008046 dimer interface [polypeptide binding]; other site 573370008047 putative CheW interface [polypeptide binding]; other site 573370008048 Heme NO binding; Region: HNOB; pfam07700 573370008049 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573370008050 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573370008051 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573370008052 active site 573370008053 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370008054 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370008055 putative active site [active] 573370008056 heme pocket [chemical binding]; other site 573370008057 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370008058 putative active site [active] 573370008059 heme pocket [chemical binding]; other site 573370008060 PAS fold; Region: PAS; pfam00989 573370008061 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370008062 putative active site [active] 573370008063 heme pocket [chemical binding]; other site 573370008064 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 573370008065 Histidine kinase; Region: HisKA_2; pfam07568 573370008066 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370008067 ATP binding site [chemical binding]; other site 573370008068 Mg2+ binding site [ion binding]; other site 573370008069 G-X-G motif; other site 573370008070 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 573370008071 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 573370008072 primosome assembly protein PriA; Validated; Region: PRK05580 573370008073 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573370008074 ATP binding site [chemical binding]; other site 573370008075 putative Mg++ binding site [ion binding]; other site 573370008076 helicase superfamily c-terminal domain; Region: HELICc; smart00490 573370008077 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 573370008078 active site 573370008079 tetramer interface; other site 573370008080 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 573370008081 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 573370008082 active site 573370008083 substrate binding site [chemical binding]; other site 573370008084 metal binding site [ion binding]; metal-binding site 573370008085 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 573370008086 YbbR-like protein; Region: YbbR; pfam07949 573370008087 Uncharacterized conserved protein [Function unknown]; Region: COG1624 573370008088 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 573370008089 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 573370008090 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 573370008091 substrate binding pocket [chemical binding]; other site 573370008092 dimer interface [polypeptide binding]; other site 573370008093 inhibitor binding site; inhibition site 573370008094 FtsH Extracellular; Region: FtsH_ext; pfam06480 573370008095 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 573370008096 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370008097 Walker A motif; other site 573370008098 ATP binding site [chemical binding]; other site 573370008099 Walker B motif; other site 573370008100 arginine finger; other site 573370008101 Peptidase family M41; Region: Peptidase_M41; pfam01434 573370008102 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370008103 active site 573370008104 phosphorylation site [posttranslational modification] 573370008105 intermolecular recognition site; other site 573370008106 dimerization interface [polypeptide binding]; other site 573370008107 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370008108 PAS domain; Region: PAS_8; pfam13188 573370008109 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370008110 putative active site [active] 573370008111 heme pocket [chemical binding]; other site 573370008112 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 573370008113 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573370008114 Zn2+ binding site [ion binding]; other site 573370008115 Mg2+ binding site [ion binding]; other site 573370008116 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 573370008117 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 573370008118 ligand binding site [chemical binding]; other site 573370008119 flexible hinge region; other site 573370008120 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 573370008121 putative switch regulator; other site 573370008122 non-specific DNA interactions [nucleotide binding]; other site 573370008123 DNA binding site [nucleotide binding] 573370008124 sequence specific DNA binding site [nucleotide binding]; other site 573370008125 putative cAMP binding site [chemical binding]; other site 573370008126 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 573370008127 ACS interaction site; other site 573370008128 CODH interaction site; other site 573370008129 metal cluster binding site [ion binding]; other site 573370008130 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573370008131 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 573370008132 DHH family; Region: DHH; pfam01368 573370008133 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 573370008134 DHHA2 domain; Region: DHHA2; pfam02833 573370008135 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 573370008136 active site 573370008137 phosphorylation site [posttranslational modification] 573370008138 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 573370008139 active pocket/dimerization site; other site 573370008140 active site 573370008141 phosphorylation site [posttranslational modification] 573370008142 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 573370008143 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 573370008144 active site 573370008145 phosphorylation site [posttranslational modification] 573370008146 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 573370008147 30S subunit binding site; other site 573370008148 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 573370008149 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 573370008150 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 573370008151 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 573370008152 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 573370008153 CTP synthetase; Validated; Region: pyrG; PRK05380 573370008154 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 573370008155 Catalytic site [active] 573370008156 active site 573370008157 UTP binding site [chemical binding]; other site 573370008158 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 573370008159 active site 573370008160 putative oxyanion hole; other site 573370008161 catalytic triad [active] 573370008162 CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507 573370008163 conserved cys residue [active] 573370008164 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 573370008165 nucleoside/Zn binding site; other site 573370008166 dimer interface [polypeptide binding]; other site 573370008167 catalytic motif [active] 573370008168 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 573370008169 B12 binding site [chemical binding]; other site 573370008170 Radical SAM superfamily; Region: Radical_SAM; pfam04055 573370008171 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573370008172 FeS/SAM binding site; other site 573370008173 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 573370008174 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 573370008175 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 573370008176 structural tetrad; other site 573370008177 FOG: WD40 repeat [General function prediction only]; Region: COG2319 573370008178 FOG: WD40 repeat [General function prediction only]; Region: COG2319 573370008179 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 573370008180 Caspase domain; Region: Peptidase_C14; pfam00656 573370008181 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 573370008182 FAD binding domain; Region: FAD_binding_4; pfam01565 573370008183 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 573370008184 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 573370008185 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 573370008186 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 573370008187 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 573370008188 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573370008189 active site 573370008190 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 573370008191 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 573370008192 active site 573370008193 putative substrate binding pocket [chemical binding]; other site 573370008194 diaminopimelate aminotransferase; Provisional; Region: PRK13983 573370008195 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like1; cd05650 573370008196 metal binding site [ion binding]; metal-binding site 573370008197 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370008198 Methyltransferase domain; Region: Methyltransf_31; pfam13847 573370008199 S-adenosylmethionine binding site [chemical binding]; other site 573370008200 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 573370008201 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 573370008202 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 573370008203 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 573370008204 FOG: CBS domain [General function prediction only]; Region: COG0517 573370008205 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 573370008206 Transporter associated domain; Region: CorC_HlyC; smart01091 573370008207 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 573370008208 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 573370008209 putative active site [active] 573370008210 catalytic triad [active] 573370008211 putative dimer interface [polypeptide binding]; other site 573370008212 PCRF domain; Region: PCRF; pfam03462 573370008213 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 573370008214 RF-1 domain; Region: RF-1; pfam00472 573370008215 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370008216 metal binding site [ion binding]; metal-binding site 573370008217 active site 573370008218 I-site; other site 573370008219 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 573370008220 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 573370008221 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 573370008222 P-loop; other site 573370008223 P-loop; other site 573370008224 Magnesium ion binding site [ion binding]; other site 573370008225 Beta subunit of integration host factor (IHFB); Region: IHF_B; cd13836 573370008226 dimer interface [polypeptide binding]; other site 573370008227 DNA binding site [nucleotide binding] 573370008228 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 573370008229 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 573370008230 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573370008231 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 573370008232 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 573370008233 metal-binding site 573370008234 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370008235 S-adenosylmethionine binding site [chemical binding]; other site 573370008236 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 573370008237 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573370008238 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 573370008239 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 573370008240 Walker A/P-loop; other site 573370008241 ATP binding site [chemical binding]; other site 573370008242 Q-loop/lid; other site 573370008243 ABC transporter signature motif; other site 573370008244 Walker B; other site 573370008245 D-loop; other site 573370008246 H-loop/switch region; other site 573370008247 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 573370008248 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 573370008249 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573370008250 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 573370008251 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 573370008252 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 573370008253 metal-binding site 573370008254 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573370008255 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 573370008256 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 573370008257 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 573370008258 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573370008259 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 573370008260 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 573370008261 active site residue [active] 573370008262 Uncharacterized conserved protein [Function unknown]; Region: COG0432 573370008263 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 573370008264 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 573370008265 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 573370008266 dimer interface [polypeptide binding]; other site 573370008267 PYR/PP interface [polypeptide binding]; other site 573370008268 TPP binding site [chemical binding]; other site 573370008269 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 573370008270 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 573370008271 TPP-binding site [chemical binding]; other site 573370008272 dimer interface [polypeptide binding]; other site 573370008273 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370008274 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370008275 putative active site [active] 573370008276 heme pocket [chemical binding]; other site 573370008277 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370008278 putative active site [active] 573370008279 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573370008280 heme pocket [chemical binding]; other site 573370008281 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370008282 dimer interface [polypeptide binding]; other site 573370008283 phosphorylation site [posttranslational modification] 573370008284 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370008285 ATP binding site [chemical binding]; other site 573370008286 Mg2+ binding site [ion binding]; other site 573370008287 G-X-G motif; other site 573370008288 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370008289 active site 573370008290 phosphorylation site [posttranslational modification] 573370008291 intermolecular recognition site; other site 573370008292 dimerization interface [polypeptide binding]; other site 573370008293 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 573370008294 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573370008295 substrate binding pocket [chemical binding]; other site 573370008296 membrane-bound complex binding site; other site 573370008297 hinge residues; other site 573370008298 ThiS family; Region: ThiS; pfam02597 573370008299 charged pocket; other site 573370008300 hydrophobic patch; other site 573370008301 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 573370008302 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 573370008303 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573370008304 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573370008305 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 573370008306 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 573370008307 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 573370008308 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 573370008309 NAD binding site [chemical binding]; other site 573370008310 homotetramer interface [polypeptide binding]; other site 573370008311 homodimer interface [polypeptide binding]; other site 573370008312 substrate binding site [chemical binding]; other site 573370008313 active site 573370008314 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573370008315 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573370008316 Methylamine utilisation protein MauE; Region: MauE; pfam07291 573370008317 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 573370008318 active site residue [active] 573370008319 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 573370008320 active site residue [active] 573370008321 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 573370008322 diiron binding motif [ion binding]; other site 573370008323 Domain of unknown function (DUF307); Region: DUF307; pfam03733 573370008324 hypothetical protein; Provisional; Region: PRK11770 573370008325 Domain of unknown function (DUF307); Region: DUF307; pfam03733 573370008326 Protein of unknown function, DUF606; Region: DUF606; pfam04657 573370008327 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 573370008328 active site 1 [active] 573370008329 dimer interface [polypeptide binding]; other site 573370008330 hexamer interface [polypeptide binding]; other site 573370008331 active site 2 [active] 573370008332 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 573370008333 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573370008334 salt bridge; other site 573370008335 non-specific DNA binding site [nucleotide binding]; other site 573370008336 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573370008337 sequence-specific DNA binding site [nucleotide binding]; other site 573370008338 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 573370008339 NapD protein; Region: NapD; cl01163 573370008340 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573370008341 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573370008342 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573370008343 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 573370008344 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 573370008345 30S ribosomal protein S1; Provisional; Region: rpsA; PRK13806 573370008346 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 573370008347 RNA binding site [nucleotide binding]; other site 573370008348 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 573370008349 RNA binding site [nucleotide binding]; other site 573370008350 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 573370008351 RNA binding site [nucleotide binding]; other site 573370008352 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 573370008353 RNA binding site [nucleotide binding]; other site 573370008354 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 573370008355 RNA binding site [nucleotide binding]; other site 573370008356 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 573370008357 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573370008358 ABC transporter; Region: ABC_tran_2; pfam12848 573370008359 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573370008360 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370008361 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 573370008362 dimer interface [polypeptide binding]; other site 573370008363 putative CheW interface [polypeptide binding]; other site 573370008364 Chemoreceptor zinc-binding domain; Region: CZB; pfam13682 573370008365 Nif-specific regulatory protein; Region: nifA; TIGR01817 573370008366 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 573370008367 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370008368 Walker A motif; other site 573370008369 ATP binding site [chemical binding]; other site 573370008370 Walker B motif; other site 573370008371 arginine finger; other site 573370008372 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 573370008373 argininosuccinate lyase; Provisional; Region: PRK00855 573370008374 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 573370008375 active sites [active] 573370008376 tetramer interface [polypeptide binding]; other site 573370008377 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 573370008378 ANP binding site [chemical binding]; other site 573370008379 Substrate Binding Site II [chemical binding]; other site 573370008380 Substrate Binding Site I [chemical binding]; other site 573370008381 ornithine carbamoyltransferase; Provisional; Region: PRK00779 573370008382 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 573370008383 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 573370008384 Bacterial SH3 domain; Region: SH3_3; pfam08239 573370008385 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 573370008386 active site 573370008387 catalytic triad [active] 573370008388 oxyanion hole [active] 573370008389 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 573370008390 active site 573370008391 catalytic triad [active] 573370008392 oxyanion hole [active] 573370008393 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 573370008394 active site 573370008395 catalytic triad [active] 573370008396 oxyanion hole [active] 573370008397 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573370008398 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 573370008399 active site 573370008400 catalytic triad [active] 573370008401 oxyanion hole [active] 573370008402 Domain of unknown function (DUF364); Region: DUF364; pfam04016 573370008403 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 573370008404 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 573370008405 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 573370008406 FMN binding site [chemical binding]; other site 573370008407 active site 573370008408 catalytic residues [active] 573370008409 substrate binding site [chemical binding]; other site 573370008410 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 573370008411 Fe-S cluster binding site [ion binding]; other site 573370008412 substrate binding site [chemical binding]; other site 573370008413 catalytic site [active] 573370008414 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 573370008415 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370008416 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370008417 active site 573370008418 phosphorylation site [posttranslational modification] 573370008419 intermolecular recognition site; other site 573370008420 dimerization interface [polypeptide binding]; other site 573370008421 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370008422 binding surface 573370008423 TPR motif; other site 573370008424 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 573370008425 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 573370008426 dimer interface [polypeptide binding]; other site 573370008427 PYR/PP interface [polypeptide binding]; other site 573370008428 TPP binding site [chemical binding]; other site 573370008429 substrate binding site [chemical binding]; other site 573370008430 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 573370008431 TPP-binding site; other site 573370008432 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 573370008433 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 573370008434 GAF domain; Region: GAF; pfam01590 573370008435 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370008436 Walker A motif; other site 573370008437 ATP binding site [chemical binding]; other site 573370008438 Walker B motif; other site 573370008439 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 573370008440 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 573370008441 tetrathionate reductase subunit A; Provisional; Region: PRK14991 573370008442 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 573370008443 molybdopterin cofactor binding site; other site 573370008444 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 573370008445 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 573370008446 molybdopterin cofactor binding site; other site 573370008447 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 573370008448 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 573370008449 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 573370008450 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 573370008451 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 573370008452 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 573370008453 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 573370008454 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 573370008455 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 573370008456 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 573370008457 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 573370008458 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 573370008459 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573370008460 FeS/SAM binding site; other site 573370008461 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 573370008462 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 573370008463 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 573370008464 NADP-binding site; other site 573370008465 homotetramer interface [polypeptide binding]; other site 573370008466 substrate binding site [chemical binding]; other site 573370008467 homodimer interface [polypeptide binding]; other site 573370008468 active site 573370008469 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 573370008470 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 573370008471 NADP-binding site; other site 573370008472 homotetramer interface [polypeptide binding]; other site 573370008473 substrate binding site [chemical binding]; other site 573370008474 homodimer interface [polypeptide binding]; other site 573370008475 active site 573370008476 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 573370008477 metal binding site 2 [ion binding]; metal-binding site 573370008478 putative DNA binding helix; other site 573370008479 metal binding site 1 [ion binding]; metal-binding site 573370008480 dimer interface [polypeptide binding]; other site 573370008481 structural Zn2+ binding site [ion binding]; other site 573370008482 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 573370008483 ABC-ATPase subunit interface; other site 573370008484 dimer interface [polypeptide binding]; other site 573370008485 putative PBP binding regions; other site 573370008486 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 573370008487 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 573370008488 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 573370008489 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 573370008490 intersubunit interface [polypeptide binding]; other site 573370008491 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 573370008492 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 573370008493 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 573370008494 dimer interface [polypeptide binding]; other site 573370008495 active site 573370008496 catalytic residue [active] 573370008497 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 573370008498 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573370008499 Walker A/P-loop; other site 573370008500 ATP binding site [chemical binding]; other site 573370008501 ABC transporter signature motif; other site 573370008502 Walker B; other site 573370008503 D-loop; other site 573370008504 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 573370008505 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573370008506 Walker A/P-loop; other site 573370008507 ATP binding site [chemical binding]; other site 573370008508 Q-loop/lid; other site 573370008509 ABC transporter signature motif; other site 573370008510 Walker B; other site 573370008511 D-loop; other site 573370008512 H-loop/switch region; other site 573370008513 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 573370008514 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573370008515 Mechanosensitive ion channel; Region: MS_channel; pfam00924 573370008516 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 573370008517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 573370008518 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 573370008519 malate synthase G; Provisional; Region: PRK02999 573370008520 active site 573370008521 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 573370008522 FMN binding site [chemical binding]; other site 573370008523 dimer interface [polypeptide binding]; other site 573370008524 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 573370008525 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 573370008526 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370008527 S-adenosylmethionine binding site [chemical binding]; other site 573370008528 PAS fold; Region: PAS_4; pfam08448 573370008529 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370008530 putative active site [active] 573370008531 heme pocket [chemical binding]; other site 573370008532 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 573370008533 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370008534 Walker A motif; other site 573370008535 ATP binding site [chemical binding]; other site 573370008536 Walker B motif; other site 573370008537 arginine finger; other site 573370008538 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 573370008539 threonine synthase; Validated; Region: PRK06260 573370008540 Hydrogenase expression/synthesis hypA family; Region: HypA; cl19201 573370008541 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 573370008542 homodimer interface [polypeptide binding]; other site 573370008543 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573370008544 catalytic residue [active] 573370008545 Protein of unknown function (DUF456); Region: DUF456; pfam04306 573370008546 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 573370008547 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 573370008548 acyl-activating enzyme (AAE) consensus motif; other site 573370008549 AMP binding site [chemical binding]; other site 573370008550 active site 573370008551 CoA binding site [chemical binding]; other site 573370008552 replicative DNA helicase; Region: DnaB; TIGR00665 573370008553 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 573370008554 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 573370008555 Walker A motif; other site 573370008556 ATP binding site [chemical binding]; other site 573370008557 Walker B motif; other site 573370008558 DNA binding loops [nucleotide binding] 573370008559 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 573370008560 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 573370008561 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 573370008562 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 573370008563 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 573370008564 Cache domain; Region: Cache_1; pfam02743 573370008565 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 573370008566 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370008567 dimerization interface [polypeptide binding]; other site 573370008568 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 573370008569 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 573370008570 Ferredoxin [Energy production and conversion]; Region: COG1146 573370008571 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 573370008572 Nitroreductase family. Members of this family utilize FMN as a cofactor. This family is involved in the reduction of flavin or nitroaromatic compounds by using NAD(P)H as electron donor in a obligatory two-electron transfer. Nitrogenase is homodimer; Region: NADH_nitroreductase; cd02143 573370008573 putative FMN binding site [chemical binding]; other site 573370008574 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370008575 active site 573370008576 phosphorylation site [posttranslational modification] 573370008577 intermolecular recognition site; other site 573370008578 dimerization interface [polypeptide binding]; other site 573370008579 HflC protein; Region: hflC; TIGR01932 573370008580 High frequency of lysogenization C (HflC) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflC; cd03405 573370008581 High frequency of lysogenization K (HflK) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflK; cd03404 573370008582 HflK protein; Region: hflK; TIGR01933 573370008583 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 573370008584 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 573370008585 active site 573370008586 substrate binding site [chemical binding]; other site 573370008587 metal binding site [ion binding]; metal-binding site 573370008588 macrolide transporter subunit MacA; Provisional; Region: PRK11578 573370008589 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 573370008590 HlyD family secretion protein; Region: HlyD_3; pfam13437 573370008591 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 573370008592 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 573370008593 Walker A/P-loop; other site 573370008594 ATP binding site [chemical binding]; other site 573370008595 Q-loop/lid; other site 573370008596 ABC transporter signature motif; other site 573370008597 Walker B; other site 573370008598 D-loop; other site 573370008599 H-loop/switch region; other site 573370008600 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573370008601 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 573370008602 FtsX-like permease family; Region: FtsX; pfam02687 573370008603 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 573370008604 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573370008605 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 573370008606 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 573370008607 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 573370008608 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573370008609 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 573370008610 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 573370008611 putative CheA interaction surface; other site 573370008612 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370008613 dimerization interface [polypeptide binding]; other site 573370008614 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370008615 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573370008616 dimer interface [polypeptide binding]; other site 573370008617 putative CheW interface [polypeptide binding]; other site 573370008618 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 573370008619 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370008620 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370008621 putative active site [active] 573370008622 heme pocket [chemical binding]; other site 573370008623 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370008624 putative active site [active] 573370008625 heme pocket [chemical binding]; other site 573370008626 GAF domain; Region: GAF_2; pfam13185 573370008627 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370008628 PAS fold; Region: PAS_3; pfam08447 573370008629 putative active site [active] 573370008630 heme pocket [chemical binding]; other site 573370008631 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370008632 dimer interface [polypeptide binding]; other site 573370008633 phosphorylation site [posttranslational modification] 573370008634 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370008635 ATP binding site [chemical binding]; other site 573370008636 Mg2+ binding site [ion binding]; other site 573370008637 G-X-G motif; other site 573370008638 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370008639 active site 573370008640 phosphorylation site [posttranslational modification] 573370008641 intermolecular recognition site; other site 573370008642 dimerization interface [polypeptide binding]; other site 573370008643 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 573370008644 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573370008645 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 573370008646 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370008647 metal binding site [ion binding]; metal-binding site 573370008648 active site 573370008649 HAMP domain; Region: HAMP; pfam00672 573370008650 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370008651 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370008652 putative active site [active] 573370008653 heme pocket [chemical binding]; other site 573370008654 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370008655 putative active site [active] 573370008656 heme pocket [chemical binding]; other site 573370008657 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370008658 putative active site [active] 573370008659 PAS fold; Region: PAS_3; pfam08447 573370008660 heme pocket [chemical binding]; other site 573370008661 PAS domain S-box; Region: sensory_box; TIGR00229 573370008662 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370008663 putative active site [active] 573370008664 heme pocket [chemical binding]; other site 573370008665 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573370008666 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370008667 dimer interface [polypeptide binding]; other site 573370008668 phosphorylation site [posttranslational modification] 573370008669 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370008670 ATP binding site [chemical binding]; other site 573370008671 Mg2+ binding site [ion binding]; other site 573370008672 G-X-G motif; other site 573370008673 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 573370008674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370008675 active site 573370008676 phosphorylation site [posttranslational modification] 573370008677 intermolecular recognition site; other site 573370008678 dimerization interface [polypeptide binding]; other site 573370008679 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573370008680 Zn2+ binding site [ion binding]; other site 573370008681 Mg2+ binding site [ion binding]; other site 573370008682 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 573370008683 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370008684 active site 573370008685 phosphorylation site [posttranslational modification] 573370008686 intermolecular recognition site; other site 573370008687 dimerization interface [polypeptide binding]; other site 573370008688 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 573370008689 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370008690 active site 573370008691 phosphorylation site [posttranslational modification] 573370008692 intermolecular recognition site; other site 573370008693 dimerization interface [polypeptide binding]; other site 573370008694 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 573370008695 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573370008696 Zn2+ binding site [ion binding]; other site 573370008697 Mg2+ binding site [ion binding]; other site 573370008698 PAS fold; Region: PAS_4; pfam08448 573370008699 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 573370008700 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370008701 putative active site [active] 573370008702 heme pocket [chemical binding]; other site 573370008703 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370008704 dimer interface [polypeptide binding]; other site 573370008705 phosphorylation site [posttranslational modification] 573370008706 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370008707 ATP binding site [chemical binding]; other site 573370008708 Mg2+ binding site [ion binding]; other site 573370008709 G-X-G motif; other site 573370008710 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 573370008711 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573370008712 substrate binding pocket [chemical binding]; other site 573370008713 membrane-bound complex binding site; other site 573370008714 hinge residues; other site 573370008715 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573370008716 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370008717 active site 573370008718 phosphorylation site [posttranslational modification] 573370008719 intermolecular recognition site; other site 573370008720 dimerization interface [polypeptide binding]; other site 573370008721 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573370008722 DNA binding residues [nucleotide binding] 573370008723 Transposase domain (DUF772); Region: DUF772; pfam05598 573370008724 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573370008725 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 573370008726 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 573370008727 Part of AAA domain; Region: AAA_19; pfam13245 573370008728 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 573370008729 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 573370008730 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 573370008731 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573370008732 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 573370008733 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 573370008734 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 573370008735 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573370008736 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 573370008737 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 573370008738 Right handed beta helix region; Region: Beta_helix; pfam13229 573370008739 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 573370008740 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 573370008741 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370008742 dimerization interface [polypeptide binding]; other site 573370008743 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 573370008744 dimer interface [polypeptide binding]; other site 573370008745 putative CheW interface [polypeptide binding]; other site 573370008746 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 573370008747 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573370008748 FtsX-like permease family; Region: FtsX; pfam02687 573370008749 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 573370008750 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573370008751 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 573370008752 DNA binding residues [nucleotide binding] 573370008753 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 573370008754 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 573370008755 ADP binding site [chemical binding]; other site 573370008756 magnesium binding site [ion binding]; other site 573370008757 putative shikimate binding site; other site 573370008758 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 573370008759 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 573370008760 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 573370008761 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 573370008762 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 573370008763 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 573370008764 Cysteine-rich domain; Region: CCG; pfam02754 573370008765 Cysteine-rich domain; Region: CCG; pfam02754 573370008766 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 573370008767 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 573370008768 oxalacetate binding site [chemical binding]; other site 573370008769 citrylCoA binding site [chemical binding]; other site 573370008770 coenzyme A binding site [chemical binding]; other site 573370008771 catalytic triad [active] 573370008772 domain in high mobilty group proteins HMG14 and HMG 17; Region: HMG17; smart00527 573370008773 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 573370008774 Mechanosensitive ion channel; Region: MS_channel; pfam00924 573370008775 Flagellar L-ring protein; Region: FlgH; cl19182 573370008776 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 573370008777 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 573370008778 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 573370008779 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 573370008780 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 573370008781 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 573370008782 active site 573370008783 hydrophilic channel; other site 573370008784 dimerization interface [polypeptide binding]; other site 573370008785 catalytic residues [active] 573370008786 active site lid [active] 573370008787 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK14657 573370008788 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 573370008789 amidohydrolase; Region: amidohydrolases; TIGR01891 573370008790 metal binding site [ion binding]; metal-binding site 573370008791 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 573370008792 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 573370008793 active site 573370008794 catalytic tetrad [active] 573370008795 ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163 573370008796 4Fe-4S binding domain; Region: Fer4_5; pfam12801 573370008797 4Fe-4S binding domain; Region: Fer4_5; pfam12801 573370008798 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 573370008799 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 573370008800 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 573370008801 Domain of unknown function (DUF362); Region: DUF362; pfam04015 573370008802 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 573370008803 Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544 573370008804 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 573370008805 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 573370008806 N-terminal plug; other site 573370008807 ligand-binding site [chemical binding]; other site 573370008808 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 573370008809 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 573370008810 Walker A/P-loop; other site 573370008811 ATP binding site [chemical binding]; other site 573370008812 ABC transporter signature motif; other site 573370008813 Walker B; other site 573370008814 D-loop; other site 573370008815 H-loop/switch region; other site 573370008816 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 573370008817 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 573370008818 Walker A/P-loop; other site 573370008819 ATP binding site [chemical binding]; other site 573370008820 Q-loop/lid; other site 573370008821 ABC transporter signature motif; other site 573370008822 Walker B; other site 573370008823 D-loop; other site 573370008824 H-loop/switch region; other site 573370008825 Cobalt transport protein; Region: CbiQ; cl00463 573370008826 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 573370008827 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573370008828 FeS/SAM binding site; other site 573370008829 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370008830 S-adenosylmethionine binding site [chemical binding]; other site 573370008831 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 573370008832 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 573370008833 non-specific DNA interactions [nucleotide binding]; other site 573370008834 DNA binding site [nucleotide binding] 573370008835 sequence specific DNA binding site [nucleotide binding]; other site 573370008836 putative cAMP binding site [chemical binding]; other site 573370008837 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 573370008838 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 573370008839 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 573370008840 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 573370008841 amphipathic channel; other site 573370008842 Asn-Pro-Ala signature motifs; other site 573370008843 glycerol kinase; Provisional; Region: glpK; PRK00047 573370008844 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 573370008845 N- and C-terminal domain interface [polypeptide binding]; other site 573370008846 active site 573370008847 MgATP binding site [chemical binding]; other site 573370008848 catalytic site [active] 573370008849 metal binding site [ion binding]; metal-binding site 573370008850 glycerol binding site [chemical binding]; other site 573370008851 homotetramer interface [polypeptide binding]; other site 573370008852 homodimer interface [polypeptide binding]; other site 573370008853 FBP binding site [chemical binding]; other site 573370008854 protein IIAGlc interface [polypeptide binding]; other site 573370008855 putative metalloenzyme radical SAM/SPASM domain maturase; Region: rSAM_Geo_metal; TIGR04311 573370008856 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573370008857 FeS/SAM binding site; other site 573370008858 Iron-sulfur cluster-binding domain; Region: SPASM; pfam13186 573370008859 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183 573370008860 putative active site [active] 573370008861 metal binding site [ion binding]; metal-binding site 573370008862 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 573370008863 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 573370008864 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 573370008865 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 573370008866 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 573370008867 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 573370008868 NADH dehydrogenase subunit B; Validated; Region: PRK06411 573370008869 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 573370008870 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 573370008871 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 573370008872 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 573370008873 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 573370008874 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12668 573370008875 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 573370008876 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 573370008877 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 573370008878 NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; Region: NuoK; COG0713 573370008879 NADH-ubiquinone/plastoquinone oxidoreductase chain 6; Region: Oxidored_q3; cl17265 573370008880 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 573370008881 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 573370008882 FMN binding site [chemical binding]; other site 573370008883 substrate binding site [chemical binding]; other site 573370008884 putative catalytic residue [active] 573370008885 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370008886 S-adenosylmethionine binding site [chemical binding]; other site 573370008887 Protein of unknown function (DUF3419); Region: DUF3419; pfam11899 573370008888 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573370008889 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573370008890 putative substrate translocation pore; other site 573370008891 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370008892 S-adenosylmethionine binding site [chemical binding]; other site 573370008893 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 573370008894 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573370008895 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573370008896 homodimer interface [polypeptide binding]; other site 573370008897 catalytic residue [active] 573370008898 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 573370008899 catalytic residues [active] 573370008900 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 573370008901 conserved hypothetical protein; Region: TIGR02285 573370008902 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 573370008903 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 573370008904 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370008905 active site 573370008906 phosphorylation site [posttranslational modification] 573370008907 intermolecular recognition site; other site 573370008908 dimerization interface [polypeptide binding]; other site 573370008909 putative cation:proton antiport protein; Provisional; Region: PRK10669 573370008910 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 573370008911 TrkA-N domain; Region: TrkA_N; pfam02254 573370008912 Transcriptional regulators [Transcription]; Region: MarR; COG1846 573370008913 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 573370008914 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 573370008915 putative cation:proton antiport protein; Provisional; Region: PRK10669 573370008916 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 573370008917 TrkA-N domain; Region: TrkA_N; pfam02254 573370008918 TrkA-C domain; Region: TrkA_C; pfam02080 573370008919 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 573370008920 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; cl19124 573370008921 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 573370008922 MMPL family; Region: MMPL; cl14618 573370008923 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 573370008924 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 573370008925 HlyD family secretion protein; Region: HlyD_3; pfam13437 573370008926 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 573370008927 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573370008928 substrate binding pocket [chemical binding]; other site 573370008929 Ion channel; Region: Ion_trans_2; pfam07885 573370008930 membrane-bound complex binding site; other site 573370008931 hinge residues; other site 573370008932 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 573370008933 Mechanosensitive ion channel; Region: MS_channel; pfam00924 573370008934 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 573370008935 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 573370008936 Peptidase family M23; Region: Peptidase_M23; pfam01551 573370008937 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 573370008938 phosphoenolpyruvate synthase; Validated; Region: PRK06464 573370008939 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; cl17700 573370008940 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 573370008941 pyruvate carboxylase; Reviewed; Region: PRK12999 573370008942 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 573370008943 ATP-grasp domain; Region: ATP-grasp_4; cl17255 573370008944 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 573370008945 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 573370008946 active site 573370008947 catalytic residues [active] 573370008948 metal binding site [ion binding]; metal-binding site 573370008949 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 573370008950 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 573370008951 carboxyltransferase (CT) interaction site; other site 573370008952 biotinylation site [posttranslational modification]; other site 573370008953 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 573370008954 Double zinc ribbon; Region: DZR; pfam12773 573370008955 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 573370008956 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 573370008957 Poly A polymerase head domain; Region: PolyA_pol; pfam01743 573370008958 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 573370008959 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 573370008960 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 573370008961 active site 573370008962 NTP binding site [chemical binding]; other site 573370008963 metal binding triad [ion binding]; metal-binding site 573370008964 antibiotic binding site [chemical binding]; other site 573370008965 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 573370008966 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 573370008967 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370008968 Walker A motif; other site 573370008969 ATP binding site [chemical binding]; other site 573370008970 Walker B motif; other site 573370008971 arginine finger; other site 573370008972 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 573370008973 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 573370008974 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 573370008975 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370008976 Walker A motif; other site 573370008977 ATP binding site [chemical binding]; other site 573370008978 Walker B motif; other site 573370008979 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 573370008980 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 573370008981 oligomer interface [polypeptide binding]; other site 573370008982 active site residues [active] 573370008983 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 573370008984 trigger factor; Region: tig; TIGR00115 573370008985 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 573370008986 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 573370008987 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; cl19816 573370008988 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 573370008989 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 573370008990 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 573370008991 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 573370008992 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 573370008993 Peptidase family M23; Region: Peptidase_M23; pfam01551 573370008994 3D domain; Region: 3D; cl01439 573370008995 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 573370008996 CoA binding domain; Region: CoA_binding; cl17356 573370008997 Bacterial sugar transferase; Region: Bac_transf; pfam02397 573370008998 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 573370008999 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 573370009000 MOFRL family; Region: MOFRL; pfam05161 573370009001 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 573370009002 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 573370009003 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 573370009004 putative NADH binding site [chemical binding]; other site 573370009005 putative active site [active] 573370009006 nudix motif; other site 573370009007 putative metal binding site [ion binding]; other site 573370009008 Predicted transcriptional regulator [Transcription]; Region: COG1959 573370009009 Rrf2 family protein; Region: rrf2_super; TIGR00738 573370009010 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 573370009011 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 573370009012 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 573370009013 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 573370009014 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 573370009015 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573370009016 motif II; other site 573370009017 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 573370009018 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 573370009019 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573370009020 Zn2+ binding site [ion binding]; other site 573370009021 Mg2+ binding site [ion binding]; other site 573370009022 type II secretion system protein D; Region: type_II_gspD; TIGR02517 573370009023 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 573370009024 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 573370009025 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 573370009026 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 573370009027 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 573370009028 type II secretion system protein E; Region: type_II_gspE; TIGR02533 573370009029 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 573370009030 Walker A motif; other site 573370009031 ATP binding site [chemical binding]; other site 573370009032 Walker B motif; other site 573370009033 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573370009034 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573370009035 Domain of unknown function (DUF303); Region: DUF303; pfam03629 573370009036 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 573370009037 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 573370009038 HlyD family secretion protein; Region: HlyD_3; pfam13437 573370009039 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 573370009040 MMPL family; Region: MMPL; cl14618 573370009041 MMPL family; Region: MMPL; cl14618 573370009042 Transcriptional regulators [Transcription]; Region: MarR; COG1846 573370009043 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 573370009044 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370009045 TPR repeat; Region: TPR_11; pfam13414 573370009046 binding surface 573370009047 TPR motif; other site 573370009048 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370009049 binding surface 573370009050 TPR motif; other site 573370009051 TPR repeat; Region: TPR_11; pfam13414 573370009052 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370009053 binding surface 573370009054 TPR motif; other site 573370009055 TPR repeat; Region: TPR_11; pfam13414 573370009056 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 573370009057 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 573370009058 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 573370009059 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 573370009060 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 573370009061 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 573370009062 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 573370009063 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 573370009064 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 573370009065 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 573370009066 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 573370009067 type II secretion system protein J; Region: gspJ; TIGR01711 573370009068 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 573370009069 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 573370009070 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370009071 TPR repeat; Region: TPR_11; pfam13414 573370009072 binding surface 573370009073 TPR motif; other site 573370009074 TPR repeat; Region: TPR_11; pfam13414 573370009075 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370009076 binding surface 573370009077 TPR motif; other site 573370009078 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 573370009079 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 573370009080 Dehydroquinate synthase (DHQS)-like. DHQS catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS-like2; cd08198 573370009081 active site 573370009082 metal binding site [ion binding]; metal-binding site 573370009083 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 573370009084 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 573370009085 CoenzymeA binding site [chemical binding]; other site 573370009086 subunit interaction site [polypeptide binding]; other site 573370009087 PHB binding site; other site 573370009088 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3787; cl17897 573370009089 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 573370009090 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 573370009091 NAD binding site [chemical binding]; other site 573370009092 substrate binding site [chemical binding]; other site 573370009093 homodimer interface [polypeptide binding]; other site 573370009094 active site 573370009095 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 573370009096 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 573370009097 NADP binding site [chemical binding]; other site 573370009098 active site 573370009099 putative substrate binding site [chemical binding]; other site 573370009100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370009101 active site 573370009102 phosphorylation site [posttranslational modification] 573370009103 intermolecular recognition site; other site 573370009104 dimerization interface [polypeptide binding]; other site 573370009105 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573370009106 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370009107 dimer interface [polypeptide binding]; other site 573370009108 phosphorylation site [posttranslational modification] 573370009109 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370009110 ATP binding site [chemical binding]; other site 573370009111 Mg2+ binding site [ion binding]; other site 573370009112 G-X-G motif; other site 573370009113 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 573370009114 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 573370009115 active site 573370009116 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370009117 dimerization interface [polypeptide binding]; other site 573370009118 PAS fold; Region: PAS_4; pfam08448 573370009119 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 573370009120 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370009121 putative active site [active] 573370009122 heme pocket [chemical binding]; other site 573370009123 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370009124 dimer interface [polypeptide binding]; other site 573370009125 phosphorylation site [posttranslational modification] 573370009126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370009127 ATP binding site [chemical binding]; other site 573370009128 Mg2+ binding site [ion binding]; other site 573370009129 G-X-G motif; other site 573370009130 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370009131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370009132 active site 573370009133 phosphorylation site [posttranslational modification] 573370009134 intermolecular recognition site; other site 573370009135 dimerization interface [polypeptide binding]; other site 573370009136 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 573370009137 putative binding surface; other site 573370009138 active site 573370009139 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 573370009140 PAS domain; Region: PAS_8; pfam13188 573370009141 PAS domain; Region: PAS_9; pfam13426 573370009142 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370009143 metal binding site [ion binding]; metal-binding site 573370009144 active site 573370009145 I-site; other site 573370009146 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573370009147 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370009148 phosphorylation site [posttranslational modification] 573370009149 dimer interface [polypeptide binding]; other site 573370009150 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370009151 ATP binding site [chemical binding]; other site 573370009152 Mg2+ binding site [ion binding]; other site 573370009153 G-X-G motif; other site 573370009154 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573370009155 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370009156 active site 573370009157 phosphorylation site [posttranslational modification] 573370009158 intermolecular recognition site; other site 573370009159 dimerization interface [polypeptide binding]; other site 573370009160 Chemotaxis phosphatase CheX; Region: CheX; cl15816 573370009161 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573370009162 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 573370009163 substrate binding pocket [chemical binding]; other site 573370009164 membrane-bound complex binding site; other site 573370009165 hinge residues; other site 573370009166 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 573370009167 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573370009168 substrate binding pocket [chemical binding]; other site 573370009169 membrane-bound complex binding site; other site 573370009170 hinge residues; other site 573370009171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370009172 ATP binding site [chemical binding]; other site 573370009173 Mg2+ binding site [ion binding]; other site 573370009174 G-X-G motif; other site 573370009175 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 573370009176 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 573370009177 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 573370009178 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 573370009179 active site 573370009180 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 573370009181 Uncharacterized conserved protein [Function unknown]; Region: COG2308 573370009182 GAF domain; Region: GAF_2; pfam13185 573370009183 PAS domain S-box; Region: sensory_box; TIGR00229 573370009184 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370009185 putative active site [active] 573370009186 heme pocket [chemical binding]; other site 573370009187 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573370009188 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370009189 dimer interface [polypeptide binding]; other site 573370009190 phosphorylation site [posttranslational modification] 573370009191 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370009192 ATP binding site [chemical binding]; other site 573370009193 Mg2+ binding site [ion binding]; other site 573370009194 G-X-G motif; other site 573370009195 Transcriptional regulators [Transcription]; Region: MarR; COG1846 573370009196 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 573370009197 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 573370009198 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 573370009199 Soluble P-type ATPase [General function prediction only]; Region: COG4087 573370009200 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 573370009201 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 573370009202 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 573370009203 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 573370009204 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370009205 metal binding site [ion binding]; metal-binding site 573370009206 active site 573370009207 I-site; other site 573370009208 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 573370009209 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 573370009210 Domain of unknown function (DUF814); Region: DUF814; pfam05670 573370009211 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 573370009212 PhoH-like protein; Region: PhoH; pfam02562 573370009213 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 573370009214 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 573370009215 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 573370009216 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573370009217 Zn2+ binding site [ion binding]; other site 573370009218 Mg2+ binding site [ion binding]; other site 573370009219 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 573370009220 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370009221 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573370009222 dimer interface [polypeptide binding]; other site 573370009223 putative CheW interface [polypeptide binding]; other site 573370009224 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 573370009225 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 573370009226 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 573370009227 AMMECR1; Region: AMMECR1; pfam01871 573370009228 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 573370009229 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370009230 S-adenosylmethionine binding site [chemical binding]; other site 573370009231 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 573370009232 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 573370009233 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 573370009234 active site 573370009235 DNA binding site [nucleotide binding] 573370009236 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 573370009237 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 573370009238 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 573370009239 Catalytic site [active] 573370009240 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 573370009241 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370009242 dimerization interface [polypeptide binding]; other site 573370009243 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370009244 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573370009245 dimer interface [polypeptide binding]; other site 573370009246 putative CheW interface [polypeptide binding]; other site 573370009247 Hemerythrin; Region: Hemerythrin; cd12107 573370009248 Fe binding site [ion binding]; other site 573370009249 active site 573370009250 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 573370009251 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 573370009252 active site 573370009253 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 573370009254 homoserine dehydrogenase; Provisional; Region: PRK06349 573370009255 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 573370009256 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 573370009257 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 573370009258 aminotransferase; Validated; Region: PRK08175 573370009259 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573370009260 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573370009261 homodimer interface [polypeptide binding]; other site 573370009262 catalytic residue [active] 573370009263 PAS domain; Region: PAS_9; pfam13426 573370009264 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370009265 putative active site [active] 573370009266 heme pocket [chemical binding]; other site 573370009267 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370009268 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573370009269 dimer interface [polypeptide binding]; other site 573370009270 putative CheW interface [polypeptide binding]; other site 573370009271 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 573370009272 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 573370009273 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370009274 active site 573370009275 phosphorylation site [posttranslational modification] 573370009276 intermolecular recognition site; other site 573370009277 dimerization interface [polypeptide binding]; other site 573370009278 Beta subunit of integration host factor (IHFB); Region: IHF_B; cd13836 573370009279 dimer interface [polypeptide binding]; other site 573370009280 DNA binding site [nucleotide binding] 573370009281 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; cl19880 573370009282 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 573370009283 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370009284 Walker A motif; other site 573370009285 ATP binding site [chemical binding]; other site 573370009286 Walker B motif; other site 573370009287 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 573370009288 Integrase core domain; Region: rve; pfam00665 573370009289 PAS domain; Region: PAS_9; pfam13426 573370009290 Sensory domain found in PocR; Region: PocR; pfam10114 573370009291 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 573370009292 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370009293 putative active site [active] 573370009294 heme pocket [chemical binding]; other site 573370009295 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370009296 dimer interface [polypeptide binding]; other site 573370009297 phosphorylation site [posttranslational modification] 573370009298 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370009299 ATP binding site [chemical binding]; other site 573370009300 Mg2+ binding site [ion binding]; other site 573370009301 G-X-G motif; other site 573370009302 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370009303 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370009304 active site 573370009305 phosphorylation site [posttranslational modification] 573370009306 intermolecular recognition site; other site 573370009307 dimerization interface [polypeptide binding]; other site 573370009308 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 573370009309 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370009310 metal binding site [ion binding]; metal-binding site 573370009311 active site 573370009312 I-site; other site 573370009313 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370009314 dimerization interface [polypeptide binding]; other site 573370009315 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370009316 PAS domain; Region: PAS_9; pfam13426 573370009317 putative active site [active] 573370009318 heme pocket [chemical binding]; other site 573370009319 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370009320 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573370009321 dimer interface [polypeptide binding]; other site 573370009322 putative CheW interface [polypeptide binding]; other site 573370009323 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 573370009324 Soluble P-type ATPase [General function prediction only]; Region: COG4087 573370009325 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370009326 dimer interface [polypeptide binding]; other site 573370009327 phosphorylation site [posttranslational modification] 573370009328 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370009329 ATP binding site [chemical binding]; other site 573370009330 Mg2+ binding site [ion binding]; other site 573370009331 G-X-G motif; other site 573370009332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370009333 active site 573370009334 phosphorylation site [posttranslational modification] 573370009335 intermolecular recognition site; other site 573370009336 dimerization interface [polypeptide binding]; other site 573370009337 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370009338 active site 573370009339 phosphorylation site [posttranslational modification] 573370009340 intermolecular recognition site; other site 573370009341 dimerization interface [polypeptide binding]; other site 573370009342 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573370009343 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 573370009344 substrate binding pocket [chemical binding]; other site 573370009345 membrane-bound complex binding site; other site 573370009346 hinge residues; other site 573370009347 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 573370009348 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370009349 active site 573370009350 phosphorylation site [posttranslational modification] 573370009351 intermolecular recognition site; other site 573370009352 dimerization interface [polypeptide binding]; other site 573370009353 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573370009354 Zn2+ binding site [ion binding]; other site 573370009355 Mg2+ binding site [ion binding]; other site 573370009356 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370009357 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370009358 putative active site [active] 573370009359 heme pocket [chemical binding]; other site 573370009360 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370009361 putative active site [active] 573370009362 heme pocket [chemical binding]; other site 573370009363 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370009364 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370009365 putative active site [active] 573370009366 heme pocket [chemical binding]; other site 573370009367 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370009368 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370009369 putative active site [active] 573370009370 heme pocket [chemical binding]; other site 573370009371 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370009372 putative active site [active] 573370009373 heme pocket [chemical binding]; other site 573370009374 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370009375 metal binding site [ion binding]; metal-binding site 573370009376 active site 573370009377 I-site; other site 573370009378 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 573370009379 HAMP domain; Region: HAMP; pfam00672 573370009380 PAS domain; Region: PAS_9; pfam13426 573370009381 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 573370009382 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370009383 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573370009384 dimer interface [polypeptide binding]; other site 573370009385 putative CheW interface [polypeptide binding]; other site 573370009386 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573370009387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370009388 active site 573370009389 phosphorylation site [posttranslational modification] 573370009390 intermolecular recognition site; other site 573370009391 dimerization interface [polypeptide binding]; other site 573370009392 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573370009393 DNA binding residues [nucleotide binding] 573370009394 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 573370009395 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 573370009396 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 573370009397 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 573370009398 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 573370009399 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 573370009400 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 573370009401 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 573370009402 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 573370009403 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 573370009404 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 573370009405 Autotransporter beta-domain; Region: Autotransporter; pfam03797 573370009406 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573370009407 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370009408 active site 573370009409 phosphorylation site [posttranslational modification] 573370009410 intermolecular recognition site; other site 573370009411 dimerization interface [polypeptide binding]; other site 573370009412 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573370009413 DNA binding residues [nucleotide binding] 573370009414 dimerization interface [polypeptide binding]; other site 573370009415 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 573370009416 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 573370009417 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 573370009418 Histidine kinase; Region: HisKA_3; pfam07730 573370009419 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370009420 ATP binding site [chemical binding]; other site 573370009421 Mg2+ binding site [ion binding]; other site 573370009422 G-X-G motif; other site 573370009423 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 573370009424 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 573370009425 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 573370009426 Transposase domain (DUF772); Region: DUF772; pfam05598 573370009427 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573370009428 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 573370009429 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 573370009430 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 573370009431 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 573370009432 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 573370009433 protein binding site [polypeptide binding]; other site 573370009434 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 573370009435 protein binding site [polypeptide binding]; other site 573370009436 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14615 573370009437 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 573370009438 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 573370009439 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 573370009440 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573370009441 active site 573370009442 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 573370009443 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 573370009444 5S rRNA interface [nucleotide binding]; other site 573370009445 CTC domain interface [polypeptide binding]; other site 573370009446 L16 interface [polypeptide binding]; other site 573370009447 Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693 573370009448 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 573370009449 putative active site [active] 573370009450 catalytic residue [active] 573370009451 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 573370009452 transcription termination factor Rho; Provisional; Region: rho; PRK09376 573370009453 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 573370009454 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 573370009455 RNA binding site [nucleotide binding]; other site 573370009456 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 573370009457 multimer interface [polypeptide binding]; other site 573370009458 Walker A motif; other site 573370009459 ATP binding site [chemical binding]; other site 573370009460 Walker B motif; other site 573370009461 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 573370009462 Peptidase family M48; Region: Peptidase_M48; cl12018 573370009463 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370009464 TPR motif; other site 573370009465 binding surface 573370009466 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370009467 TPR motif; other site 573370009468 binding surface 573370009469 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 573370009470 trimer interface [polypeptide binding]; other site 573370009471 putative Zn binding site [ion binding]; other site 573370009472 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 573370009473 MG2 domain; Region: A2M_N; pfam01835 573370009474 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 573370009475 Alpha-2-macroglobulin family; Region: A2M; pfam00207 573370009476 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 573370009477 surface patch; other site 573370009478 thioester region; other site 573370009479 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 573370009480 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 573370009481 Walker A motif; other site 573370009482 ATP binding site [chemical binding]; other site 573370009483 Walker B motif; other site 573370009484 Putative lysophospholipase; Region: Hydrolase_4; cl19140 573370009485 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 573370009486 PGAP1-like protein; Region: PGAP1; pfam07819 573370009487 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 573370009488 putative rRNA binding site [nucleotide binding]; other site 573370009489 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 573370009490 active site residue [active] 573370009491 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 573370009492 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 573370009493 active site 573370009494 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 573370009495 PLD-like domain; Region: PLDc_2; pfam13091 573370009496 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 573370009497 Cache domain; Region: Cache_1; pfam02743 573370009498 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370009499 dimerization interface [polypeptide binding]; other site 573370009500 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370009501 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573370009502 dimer interface [polypeptide binding]; other site 573370009503 putative CheW interface [polypeptide binding]; other site 573370009504 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370009505 PAS domain; Region: PAS_9; pfam13426 573370009506 putative active site [active] 573370009507 heme pocket [chemical binding]; other site 573370009508 GAF domain; Region: GAF_3; pfam13492 573370009509 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 573370009510 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370009511 putative active site [active] 573370009512 heme pocket [chemical binding]; other site 573370009513 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370009514 dimer interface [polypeptide binding]; other site 573370009515 phosphorylation site [posttranslational modification] 573370009516 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370009517 ATP binding site [chemical binding]; other site 573370009518 Mg2+ binding site [ion binding]; other site 573370009519 G-X-G motif; other site 573370009520 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370009521 active site 573370009522 phosphorylation site [posttranslational modification] 573370009523 intermolecular recognition site; other site 573370009524 dimerization interface [polypeptide binding]; other site 573370009525 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370009526 active site 573370009527 phosphorylation site [posttranslational modification] 573370009528 intermolecular recognition site; other site 573370009529 dimerization interface [polypeptide binding]; other site 573370009530 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 573370009531 putative binding surface; other site 573370009532 active site 573370009533 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 573370009534 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370009535 active site 573370009536 phosphorylation site [posttranslational modification] 573370009537 intermolecular recognition site; other site 573370009538 dimerization interface [polypeptide binding]; other site 573370009539 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573370009540 Zn2+ binding site [ion binding]; other site 573370009541 Mg2+ binding site [ion binding]; other site 573370009542 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370009543 active site 573370009544 phosphorylation site [posttranslational modification] 573370009545 intermolecular recognition site; other site 573370009546 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573370009547 dimerization interface [polypeptide binding]; other site 573370009548 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370009549 phosphorylation site [posttranslational modification] 573370009550 dimer interface [polypeptide binding]; other site 573370009551 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370009552 ATP binding site [chemical binding]; other site 573370009553 Mg2+ binding site [ion binding]; other site 573370009554 G-X-G motif; other site 573370009555 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 573370009556 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 573370009557 transmembrane helices; other site 573370009558 adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854 573370009559 L-aspartate oxidase; Provisional; Region: PRK06175 573370009560 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 573370009561 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 573370009562 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 573370009563 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 573370009564 ligand binding site [chemical binding]; other site 573370009565 flexible hinge region; other site 573370009566 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 573370009567 non-specific DNA interactions [nucleotide binding]; other site 573370009568 DNA binding site [nucleotide binding] 573370009569 sequence specific DNA binding site [nucleotide binding]; other site 573370009570 putative cAMP binding site [chemical binding]; other site 573370009571 hypothetical protein; Provisional; Region: PRK09898 573370009572 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 573370009573 putative oxidoreductase; Provisional; Region: PRK09849 573370009574 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 573370009575 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 573370009576 hypothetical protein; Provisional; Region: PRK09947 573370009577 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 573370009578 putative chaperone; Provisional; Region: PRK11678 573370009579 nucleotide binding site [chemical binding]; other site 573370009580 putative NEF/HSP70 interaction site [polypeptide binding]; other site 573370009581 SBD interface [polypeptide binding]; other site 573370009582 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 573370009583 active site 573370009584 catalytic triad [active] 573370009585 oxyanion hole [active] 573370009586 Autotransporter beta-domain; Region: Autotransporter; cl17461 573370009587 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 573370009588 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573370009589 motif II; other site 573370009590 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573370009591 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573370009592 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 573370009593 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 573370009594 HlyD family secretion protein; Region: HlyD_3; pfam13437 573370009595 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 573370009596 MMPL family; Region: MMPL; cl14618 573370009597 Helix-turn-helix domain; Region: HTH_28; pfam13518 573370009598 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573370009599 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 573370009600 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 573370009601 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573370009602 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 573370009603 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 573370009604 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 573370009605 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573370009606 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573370009607 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 573370009608 substrate binding pocket [chemical binding]; other site 573370009609 dimerization interface [polypeptide binding]; other site 573370009610 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 573370009611 HAMP domain; Region: HAMP; pfam00672 573370009612 PAS domain; Region: PAS; smart00091 573370009613 PAS domain; Region: PAS_9; pfam13426 573370009614 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 573370009615 dimer interface [polypeptide binding]; other site 573370009616 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370009617 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573370009618 dimer interface [polypeptide binding]; other site 573370009619 putative CheW interface [polypeptide binding]; other site 573370009620 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 573370009621 putative CheA interaction surface; other site 573370009622 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370009623 dimerization interface [polypeptide binding]; other site 573370009624 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370009625 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573370009626 dimer interface [polypeptide binding]; other site 573370009627 putative CheW interface [polypeptide binding]; other site 573370009628 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 573370009629 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370009630 active site 573370009631 phosphorylation site [posttranslational modification] 573370009632 intermolecular recognition site; other site 573370009633 dimerization interface [polypeptide binding]; other site 573370009634 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370009635 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370009636 putative active site [active] 573370009637 heme pocket [chemical binding]; other site 573370009638 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370009639 putative active site [active] 573370009640 heme pocket [chemical binding]; other site 573370009641 GAF domain; Region: GAF_2; pfam13185 573370009642 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 573370009643 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370009644 dimer interface [polypeptide binding]; other site 573370009645 phosphorylation site [posttranslational modification] 573370009646 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370009647 ATP binding site [chemical binding]; other site 573370009648 Mg2+ binding site [ion binding]; other site 573370009649 G-X-G motif; other site 573370009650 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370009651 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370009652 active site 573370009653 phosphorylation site [posttranslational modification] 573370009654 intermolecular recognition site; other site 573370009655 dimerization interface [polypeptide binding]; other site 573370009656 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370009657 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370009658 active site 573370009659 phosphorylation site [posttranslational modification] 573370009660 intermolecular recognition site; other site 573370009661 dimerization interface [polypeptide binding]; other site 573370009662 Hemerythrin; Region: Hemerythrin; cd12107 573370009663 Fe binding site [ion binding]; other site 573370009664 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370009665 metal binding site [ion binding]; metal-binding site 573370009666 active site 573370009667 I-site; other site 573370009668 Domain of unknown function (DUF4200); Region: DUF4200; pfam13863 573370009669 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 573370009670 HSP70 interaction site [polypeptide binding]; other site 573370009671 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 573370009672 GIY-YIG motif/motif A; other site 573370009673 active site 573370009674 catalytic site [active] 573370009675 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 573370009676 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 573370009677 active site 573370009678 catalytic triad [active] 573370009679 oxyanion hole [active] 573370009680 Autotransporter beta-domain; Region: Autotransporter; cl17461 573370009681 metallophosphoesterase, PPA1498 family; Region: P_acnes_RR; cl17623 573370009682 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 573370009683 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 573370009684 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 573370009685 Autotransporter beta-domain; Region: Autotransporter; smart00869 573370009686 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 573370009687 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 573370009688 Predicted transcriptional regulator [Transcription]; Region: COG2378 573370009689 WYL domain; Region: WYL; pfam13280 573370009690 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 573370009691 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 573370009692 active site 573370009693 catalytic site [active] 573370009694 substrate binding site [chemical binding]; other site 573370009695 Transposase domain (DUF772); Region: DUF772; pfam05598 573370009696 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573370009697 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 573370009698 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370009699 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 573370009700 Walker A motif; other site 573370009701 ATP binding site [chemical binding]; other site 573370009702 Walker B motif; other site 573370009703 arginine finger; other site 573370009704 Domain of unknown function (DUF927); Region: DUF927; cl12098 573370009705 sec-independent translocase; Provisional; Region: tatB; PRK00404 573370009706 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573370009707 active site 573370009708 DNA binding site [nucleotide binding] 573370009709 Int/Topo IB signature motif; other site 573370009710 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 573370009711 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 573370009712 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 573370009713 active site 573370009714 catalytic residues [active] 573370009715 DNA binding site [nucleotide binding] 573370009716 Int/Topo IB signature motif; other site 573370009717 Hemerythrin; Region: Hemerythrin; cd12107 573370009718 Fe binding site [ion binding]; other site 573370009719 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370009720 metal binding site [ion binding]; metal-binding site 573370009721 active site 573370009722 I-site; other site 573370009723 Domain of unknown function (DUF4200); Region: DUF4200; pfam13863 573370009724 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 573370009725 HSP70 interaction site [polypeptide binding]; other site 573370009726 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 573370009727 protein binding site [polypeptide binding]; other site 573370009728 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370009729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370009730 active site 573370009731 phosphorylation site [posttranslational modification] 573370009732 intermolecular recognition site; other site 573370009733 dimerization interface [polypeptide binding]; other site 573370009734 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 573370009735 PAS domain; Region: PAS; smart00091 573370009736 PAS fold; Region: PAS_4; pfam08448 573370009737 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 573370009738 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 573370009739 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 573370009740 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573370009741 Zn2+ binding site [ion binding]; other site 573370009742 Mg2+ binding site [ion binding]; other site 573370009743 DNA-dependent RNA polymerase; Region: RNA_pol; pfam00940 573370009744 Domain of unknown function (DUF927); Region: DUF927; cl12098 573370009745 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573370009746 active site 573370009747 DNA binding site [nucleotide binding] 573370009748 Int/Topo IB signature motif; other site 573370009749 Helix-turn-helix domain; Region: HTH_17; pfam12728 573370009750 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 573370009751 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 573370009752 active site 573370009753 catalytic residues [active] 573370009754 DNA binding site [nucleotide binding] 573370009755 Int/Topo IB signature motif; other site 573370009756 Hemerythrin; Region: Hemerythrin; cd12107 573370009757 Fe binding site [ion binding]; other site 573370009758 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370009759 metal binding site [ion binding]; metal-binding site 573370009760 active site 573370009761 I-site; other site 573370009762 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 573370009763 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 573370009764 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 573370009765 selenocysteine synthase; Provisional; Region: PRK04311 573370009766 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 573370009767 L-seryl-tRNA selenium transferase; Region: SelA; pfam03841 573370009768 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573370009769 catalytic residue [active] 573370009770 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 573370009771 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573370009772 catalytic residue [active] 573370009773 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 573370009774 oligomer interface [polypeptide binding]; other site 573370009775 putative active site [active] 573370009776 metal binding site [ion binding]; metal-binding site 573370009777 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 573370009778 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 573370009779 G1 box; other site 573370009780 putative GEF interaction site [polypeptide binding]; other site 573370009781 GTP/Mg2+ binding site [chemical binding]; other site 573370009782 Switch I region; other site 573370009783 G2 box; other site 573370009784 G3 box; other site 573370009785 Switch II region; other site 573370009786 G4 box; other site 573370009787 G5 box; other site 573370009788 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 573370009789 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 573370009790 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 573370009791 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 573370009792 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 573370009793 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 573370009794 active site 573370009795 HIGH motif; other site 573370009796 dimer interface [polypeptide binding]; other site 573370009797 KMSKS motif; other site 573370009798 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 573370009799 Peptidase family M50; Region: Peptidase_M50; pfam02163 573370009800 active site 573370009801 putative substrate binding region [chemical binding]; other site 573370009802 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370009803 active site 573370009804 phosphorylation site [posttranslational modification] 573370009805 intermolecular recognition site; other site 573370009806 dimerization interface [polypeptide binding]; other site 573370009807 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 573370009808 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 573370009809 Ligand Binding Site [chemical binding]; other site 573370009810 TIGR00269 family protein; Region: TIGR00269 573370009811 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 573370009812 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cl00399 573370009813 MoaE homodimer interface [polypeptide binding]; other site 573370009814 MoaD interaction [polypeptide binding]; other site 573370009815 active site residues [active] 573370009816 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 573370009817 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 573370009818 active site 573370009819 hypothetical protein; Provisional; Region: PRK04334 573370009820 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 573370009821 Clp amino terminal domain; Region: Clp_N; pfam02861 573370009822 Clp amino terminal domain; Region: Clp_N; pfam02861 573370009823 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370009824 Walker A motif; other site 573370009825 ATP binding site [chemical binding]; other site 573370009826 Walker B motif; other site 573370009827 arginine finger; other site 573370009828 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370009829 Walker A motif; other site 573370009830 ATP binding site [chemical binding]; other site 573370009831 Walker B motif; other site 573370009832 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 573370009833 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 573370009834 DNA binding residues [nucleotide binding] 573370009835 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 573370009836 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 573370009837 HSP70 interaction site [polypeptide binding]; other site 573370009838 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 573370009839 substrate binding site [polypeptide binding]; other site 573370009840 dimer interface [polypeptide binding]; other site 573370009841 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 573370009842 Smr domain; Region: Smr; pfam01713 573370009843 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 573370009844 cysteine synthase; Region: PLN02565 573370009845 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 573370009846 dimer interface [polypeptide binding]; other site 573370009847 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573370009848 catalytic residue [active] 573370009849 Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: CysS; COG0215 573370009850 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 573370009851 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 573370009852 hypothetical protein; Provisional; Region: PRK08317 573370009853 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370009854 S-adenosylmethionine binding site [chemical binding]; other site 573370009855 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 573370009856 thiamine phosphate binding site [chemical binding]; other site 573370009857 active site 573370009858 pyrophosphate binding site [ion binding]; other site 573370009859 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 573370009860 substrate binding site [chemical binding]; other site 573370009861 multimerization interface [polypeptide binding]; other site 573370009862 ATP binding site [chemical binding]; other site 573370009863 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 573370009864 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370009865 dimer interface [polypeptide binding]; other site 573370009866 phosphorylation site [posttranslational modification] 573370009867 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370009868 ATP binding site [chemical binding]; other site 573370009869 Mg2+ binding site [ion binding]; other site 573370009870 G-X-G motif; other site 573370009871 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 573370009872 DnaA N-terminal domain; Region: DnaA_N; pfam11638 573370009873 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370009874 Walker A motif; other site 573370009875 ATP binding site [chemical binding]; other site 573370009876 Walker B motif; other site 573370009877 arginine finger; other site 573370009878 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 573370009879 DnaA box-binding interface [nucleotide binding]; other site 573370009880 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 573370009881 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 573370009882 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370009883 Walker A motif; other site 573370009884 ATP binding site [chemical binding]; other site 573370009885 Walker B motif; other site 573370009886 arginine finger; other site 573370009887 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 573370009888 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14602 573370009889 RuvA N terminal domain; Region: RuvA_N; pfam01330 573370009890 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 573370009891 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 573370009892 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 573370009893 active site 573370009894 putative DNA-binding cleft [nucleotide binding]; other site 573370009895 dimer interface [polypeptide binding]; other site 573370009896 hypothetical protein; Validated; Region: PRK00110 573370009897 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370009898 S-adenosylmethionine binding site [chemical binding]; other site 573370009899 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 573370009900 PilZ domain; Region: PilZ; pfam07238 573370009901 Uncharacterized conserved protein [Function unknown]; Region: COG5361 573370009902 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 573370009903 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 573370009904 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 573370009905 Sel1-like repeats; Region: SEL1; smart00671 573370009906 Sel1-like repeats; Region: SEL1; smart00671 573370009907 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 573370009908 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 573370009909 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573370009910 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573370009911 homodimer interface [polypeptide binding]; other site 573370009912 catalytic residue [active] 573370009913 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573370009914 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 573370009915 substrate binding pocket [chemical binding]; other site 573370009916 membrane-bound complex binding site; other site 573370009917 hinge residues; other site 573370009918 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 573370009919 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573370009920 dimer interface [polypeptide binding]; other site 573370009921 conserved gate region; other site 573370009922 putative PBP binding loops; other site 573370009923 ABC-ATPase subunit interface; other site 573370009924 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 573370009925 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 573370009926 Walker A/P-loop; other site 573370009927 ATP binding site [chemical binding]; other site 573370009928 Q-loop/lid; other site 573370009929 ABC transporter signature motif; other site 573370009930 Walker B; other site 573370009931 D-loop; other site 573370009932 H-loop/switch region; other site 573370009933 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 573370009934 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573370009935 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573370009936 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370009937 binding surface 573370009938 TPR motif; other site 573370009939 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573370009940 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 573370009941 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 573370009942 putative glutamate synthase subunit beta; Provisional; Region: PRK12770 573370009943 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 573370009944 EamA-like transporter family; Region: EamA; pfam00892 573370009945 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 573370009946 EamA-like transporter family; Region: EamA; pfam00892 573370009947 response regulator PleD; Reviewed; Region: pleD; PRK09581 573370009948 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370009949 active site 573370009950 phosphorylation site [posttranslational modification] 573370009951 intermolecular recognition site; other site 573370009952 dimerization interface [polypeptide binding]; other site 573370009953 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370009954 metal binding site [ion binding]; metal-binding site 573370009955 active site 573370009956 I-site; other site 573370009957 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573370009958 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 573370009959 substrate binding pocket [chemical binding]; other site 573370009960 membrane-bound complex binding site; other site 573370009961 hinge residues; other site 573370009962 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 573370009963 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573370009964 dimer interface [polypeptide binding]; other site 573370009965 conserved gate region; other site 573370009966 putative PBP binding loops; other site 573370009967 ABC-ATPase subunit interface; other site 573370009968 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 573370009969 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573370009970 Walker A/P-loop; other site 573370009971 ATP binding site [chemical binding]; other site 573370009972 Q-loop/lid; other site 573370009973 ABC transporter signature motif; other site 573370009974 Walker B; other site 573370009975 D-loop; other site 573370009976 H-loop/switch region; other site 573370009977 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 573370009978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573370009979 dimer interface [polypeptide binding]; other site 573370009980 conserved gate region; other site 573370009981 putative PBP binding loops; other site 573370009982 ABC-ATPase subunit interface; other site 573370009983 FAD binding domain; Region: FAD_binding_4; pfam01565 573370009984 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 573370009985 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 573370009986 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573370009987 Coenzyme A binding pocket [chemical binding]; other site 573370009988 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370009989 binding surface 573370009990 TPR motif; other site 573370009991 TPR repeat; Region: TPR_11; pfam13414 573370009992 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370009993 binding surface 573370009994 TPR motif; other site 573370009995 TPR repeat; Region: TPR_11; pfam13414 573370009996 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370009997 binding surface 573370009998 TPR motif; other site 573370009999 TPR repeat; Region: TPR_11; pfam13414 573370010000 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370010001 S-adenosylmethionine binding site [chemical binding]; other site 573370010002 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573370010003 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 573370010004 substrate binding pocket [chemical binding]; other site 573370010005 membrane-bound complex binding site; other site 573370010006 hinge residues; other site 573370010007 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370010008 metal binding site [ion binding]; metal-binding site 573370010009 active site 573370010010 I-site; other site 573370010011 NAD synthetase; Provisional; Region: PRK13981 573370010012 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 573370010013 multimer interface [polypeptide binding]; other site 573370010014 active site 573370010015 catalytic triad [active] 573370010016 protein interface 1 [polypeptide binding]; other site 573370010017 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 573370010018 homodimer interface [polypeptide binding]; other site 573370010019 NAD binding pocket [chemical binding]; other site 573370010020 ATP binding pocket [chemical binding]; other site 573370010021 Mg binding site [ion binding]; other site 573370010022 active-site loop [active] 573370010023 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 573370010024 hypothetical protein; Provisional; Region: PRK11019 573370010025 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370010026 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370010027 dimer interface [polypeptide binding]; other site 573370010028 phosphorylation site [posttranslational modification] 573370010029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370010030 ATP binding site [chemical binding]; other site 573370010031 Mg2+ binding site [ion binding]; other site 573370010032 G-X-G motif; other site 573370010033 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370010034 active site 573370010035 phosphorylation site [posttranslational modification] 573370010036 intermolecular recognition site; other site 573370010037 dimerization interface [polypeptide binding]; other site 573370010038 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370010039 metal binding site [ion binding]; metal-binding site 573370010040 active site 573370010041 I-site; other site 573370010042 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 573370010043 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 573370010044 beta and beta' interface [polypeptide binding]; other site 573370010045 beta' and sigma factor interface [polypeptide binding]; other site 573370010046 Zn-binding [ion binding]; other site 573370010047 active site region [active] 573370010048 catalytic site [active] 573370010049 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 573370010050 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 573370010051 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 573370010052 G-loop; other site 573370010053 DNA binding site [nucleotide binding] 573370010054 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 573370010055 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 573370010056 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 573370010057 RPB12 interaction site [polypeptide binding]; other site 573370010058 RPB1 interaction site [polypeptide binding]; other site 573370010059 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 573370010060 RPB10 interaction site [polypeptide binding]; other site 573370010061 RPB11 interaction site [polypeptide binding]; other site 573370010062 RPB3 interaction site [polypeptide binding]; other site 573370010063 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 573370010064 core dimer interface [polypeptide binding]; other site 573370010065 peripheral dimer interface [polypeptide binding]; other site 573370010066 L10 interface [polypeptide binding]; other site 573370010067 L11 interface [polypeptide binding]; other site 573370010068 putative EF-Tu interaction site [polypeptide binding]; other site 573370010069 putative EF-G interaction site [polypeptide binding]; other site 573370010070 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 573370010071 23S rRNA interface [nucleotide binding]; other site 573370010072 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 573370010073 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 573370010074 mRNA/rRNA interface [nucleotide binding]; other site 573370010075 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 573370010076 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 573370010077 23S rRNA interface [nucleotide binding]; other site 573370010078 L7/L12 interface [polypeptide binding]; other site 573370010079 putative thiostrepton binding site; other site 573370010080 L25 interface [polypeptide binding]; other site 573370010081 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 573370010082 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 573370010083 putative homodimer interface [polypeptide binding]; other site 573370010084 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 573370010085 heterodimer interface [polypeptide binding]; other site 573370010086 homodimer interface [polypeptide binding]; other site 573370010087 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 573370010088 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 573370010089 elongation factor Tu; Reviewed; Region: PRK00049 573370010090 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 573370010091 G1 box; other site 573370010092 GEF interaction site [polypeptide binding]; other site 573370010093 GTP/Mg2+ binding site [chemical binding]; other site 573370010094 Switch I region; other site 573370010095 G2 box; other site 573370010096 G3 box; other site 573370010097 Switch II region; other site 573370010098 G4 box; other site 573370010099 G5 box; other site 573370010100 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 573370010101 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 573370010102 Antibiotic Binding Site [chemical binding]; other site 573370010103 FtsH Extracellular; Region: FtsH_ext; pfam06480 573370010104 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 573370010105 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370010106 Walker A motif; other site 573370010107 ATP binding site [chemical binding]; other site 573370010108 Walker B motif; other site 573370010109 arginine finger; other site 573370010110 Peptidase family M41; Region: Peptidase_M41; pfam01434 573370010111 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 573370010112 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 573370010113 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370010114 S-adenosylmethionine binding site [chemical binding]; other site 573370010115 peptide chain release factor 1; Validated; Region: prfA; PRK00591 573370010116 This domain is found in peptide chain release factors; Region: PCRF; smart00937 573370010117 RF-1 domain; Region: RF-1; pfam00472 573370010118 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 573370010119 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 573370010120 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 573370010121 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 573370010122 catalytic core [active] 573370010123 GTP-binding protein Der; Reviewed; Region: PRK00093 573370010124 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 573370010125 G1 box; other site 573370010126 GTP/Mg2+ binding site [chemical binding]; other site 573370010127 Switch I region; other site 573370010128 G2 box; other site 573370010129 Switch II region; other site 573370010130 G3 box; other site 573370010131 G4 box; other site 573370010132 G5 box; other site 573370010133 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 573370010134 G1 box; other site 573370010135 GTP/Mg2+ binding site [chemical binding]; other site 573370010136 Switch I region; other site 573370010137 G2 box; other site 573370010138 G3 box; other site 573370010139 Switch II region; other site 573370010140 G4 box; other site 573370010141 G5 box; other site 573370010142 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 573370010143 Predicted periplasmic protein (DUF2092); Region: DUF2092; cl17607 573370010144 Arylsulfotransferase (ASST); Region: Arylsulfotrans; cl19972 573370010145 MAEBL; Provisional; Region: PTZ00121 573370010146 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 573370010147 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 573370010148 GatB domain; Region: GatB_Yqey; smart00845 573370010149 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 573370010150 ribulose-1,5-biphosphate synthetase; Provisional; Region: PRK04176 573370010151 thiazole biosynthesis enzyme; Region: TIGR00292 573370010152 Protein of unknown function DUF89; Region: DUF89; cl15397 573370010153 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 573370010154 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 573370010155 flagellar assembly protein FliW; Provisional; Region: PRK13285 573370010156 Global regulator protein family; Region: CsrA; pfam02599 573370010157 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 573370010158 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 573370010159 Flagellar hook-associated protein [Cell motility and secretion]; Region: FlgK; COG1256 573370010160 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 573370010161 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 573370010162 FlgN protein; Region: FlgN; pfam05130 573370010163 Rod binding protein; Region: Rod-binding; cl01626 573370010164 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 573370010165 Peptidase family M23; Region: Peptidase_M23; pfam01551 573370010166 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 573370010167 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12696 573370010168 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 573370010169 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 573370010170 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 573370010171 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 573370010172 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 573370010173 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 573370010174 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 573370010175 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 573370010176 Sm and related proteins; Region: Sm_like; cl00259 573370010177 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 573370010178 putative oligomer interface [polypeptide binding]; other site 573370010179 putative RNA binding site [nucleotide binding]; other site 573370010180 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 573370010181 NusA N-terminal domain; Region: NusA_N; pfam08529 573370010182 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 573370010183 RNA binding site [nucleotide binding]; other site 573370010184 homodimer interface [polypeptide binding]; other site 573370010185 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 573370010186 G-X-X-G motif; other site 573370010187 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 573370010188 G-X-X-G motif; other site 573370010189 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 573370010190 translation initiation factor IF-2; Validated; Region: infB; PRK05306 573370010191 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 573370010192 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 573370010193 G1 box; other site 573370010194 putative GEF interaction site [polypeptide binding]; other site 573370010195 GTP/Mg2+ binding site [chemical binding]; other site 573370010196 Switch I region; other site 573370010197 G2 box; other site 573370010198 G3 box; other site 573370010199 Switch II region; other site 573370010200 G4 box; other site 573370010201 G5 box; other site 573370010202 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 573370010203 Translation-initiation factor 2; Region: IF-2; pfam11987 573370010204 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 573370010205 Protein of unknown function (DUF503); Region: DUF503; pfam04456 573370010206 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 573370010207 DHH family; Region: DHH; pfam01368 573370010208 DHHA1 domain; Region: DHHA1; pfam02272 573370010209 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 573370010210 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 573370010211 RNA binding site [nucleotide binding]; other site 573370010212 active site 573370010213 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 573370010214 16S/18S rRNA binding site [nucleotide binding]; other site 573370010215 S13e-L30e interaction site [polypeptide binding]; other site 573370010216 25S rRNA binding site [nucleotide binding]; other site 573370010217 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 573370010218 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 573370010219 RNase E interface [polypeptide binding]; other site 573370010220 trimer interface [polypeptide binding]; other site 573370010221 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 573370010222 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 573370010223 RNase E interface [polypeptide binding]; other site 573370010224 trimer interface [polypeptide binding]; other site 573370010225 active site 573370010226 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 573370010227 putative nucleic acid binding region [nucleotide binding]; other site 573370010228 G-X-X-G motif; other site 573370010229 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 573370010230 RNA binding site [nucleotide binding]; other site 573370010231 domain interface; other site 573370010232 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 573370010233 putative ligand binding pocket/active site [active] 573370010234 putative metal binding site [ion binding]; other site 573370010235 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370010236 TPR motif; other site 573370010237 binding surface 573370010238 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370010239 TPR motif; other site 573370010240 binding surface 573370010241 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 573370010242 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370010243 TPR motif; other site 573370010244 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 573370010245 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 573370010246 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370010247 Walker A motif; other site 573370010248 ATP binding site [chemical binding]; other site 573370010249 Walker B motif; other site 573370010250 arginine finger; other site 573370010251 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 573370010252 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 573370010253 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 573370010254 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 573370010255 benzoylformate decarboxylase; Reviewed; Region: PRK07092 573370010256 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 573370010257 PYR/PP interface [polypeptide binding]; other site 573370010258 dimer interface [polypeptide binding]; other site 573370010259 TPP binding site [chemical binding]; other site 573370010260 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 573370010261 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 573370010262 TPP-binding site [chemical binding]; other site 573370010263 dimer interface [polypeptide binding]; other site 573370010264 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370010265 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 573370010266 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370010267 putative active site [active] 573370010268 heme pocket [chemical binding]; other site 573370010269 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370010270 dimer interface [polypeptide binding]; other site 573370010271 phosphorylation site [posttranslational modification] 573370010272 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370010273 ATP binding site [chemical binding]; other site 573370010274 Mg2+ binding site [ion binding]; other site 573370010275 G-X-G motif; other site 573370010276 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370010277 active site 573370010278 phosphorylation site [posttranslational modification] 573370010279 intermolecular recognition site; other site 573370010280 dimerization interface [polypeptide binding]; other site 573370010281 putative GTP cyclohydrolase; Provisional; Region: PRK13674 573370010282 nickel responsive regulator; Provisional; Region: PRK04460 573370010283 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 573370010284 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 573370010285 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370010286 S-adenosylmethionine binding site [chemical binding]; other site 573370010287 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 573370010288 lipoyl attachment site [posttranslational modification]; other site 573370010289 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 573370010290 tetramer interface [polypeptide binding]; other site 573370010291 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573370010292 catalytic residue [active] 573370010293 glycine dehydrogenase subunit 2; Validated; Region: PRK04366 573370010294 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573370010295 catalytic residue [active] 573370010296 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 573370010297 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573370010298 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 573370010299 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 573370010300 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 573370010301 active site 573370010302 dimer interface [polypeptide binding]; other site 573370010303 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 573370010304 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 573370010305 conserved cys residue [active] 573370010306 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 573370010307 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573370010308 Coenzyme A binding pocket [chemical binding]; other site 573370010309 Integrase core domain; Region: rve_3; cl15866 573370010310 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 573370010311 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 573370010312 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573370010313 Zn2+ binding site [ion binding]; other site 573370010314 Mg2+ binding site [ion binding]; other site 573370010315 GAF domain; Region: GAF_2; pfam13185 573370010316 PAS domain S-box; Region: sensory_box; TIGR00229 573370010317 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370010318 putative active site [active] 573370010319 heme pocket [chemical binding]; other site 573370010320 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573370010321 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 573370010322 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370010323 ATP binding site [chemical binding]; other site 573370010324 Mg2+ binding site [ion binding]; other site 573370010325 G-X-G motif; other site 573370010326 integrase; Provisional; Region: int; PHA02601 573370010327 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 573370010328 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 573370010329 active site 573370010330 catalytic residues [active] 573370010331 DNA binding site [nucleotide binding] 573370010332 Int/Topo IB signature motif; other site 573370010333 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573370010334 active site 573370010335 DNA binding site [nucleotide binding] 573370010336 Int/Topo IB signature motif; other site 573370010337 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 573370010338 Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences; Region: Peptidase_C1A; cd02248 573370010339 active site 573370010340 S2 subsite; other site 573370010341 Predicted transcriptional regulator [Transcription]; Region: COG2378 573370010342 Helix-turn-helix domain; Region: HTH_20; pfam12840 573370010343 WYL domain; Region: WYL; pfam13280 573370010344 Protein of unknown function (DUF3024); Region: DUF3024; pfam11225 573370010345 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 573370010346 Abortive infection C-terminus; Region: Abi_C; pfam14355 573370010347 integrase; Provisional; Region: int; PHA02601 573370010348 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 573370010349 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 573370010350 active site 573370010351 catalytic residues [active] 573370010352 DNA binding site [nucleotide binding] 573370010353 Int/Topo IB signature motif; other site 573370010354 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573370010355 active site 573370010356 DNA binding site [nucleotide binding] 573370010357 Int/Topo IB signature motif; other site 573370010358 Replicase family; Region: Replicase; pfam03090 573370010359 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 573370010360 major capsid protein; Region: PHA01075 573370010361 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; cl19880 573370010362 GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440 573370010363 GIY-YIG motif/motif A; other site 573370010364 putative active site [active] 573370010365 putative metal binding site [ion binding]; other site 573370010366 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 573370010367 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 573370010368 Walker A motif; other site 573370010369 ATP binding site [chemical binding]; other site 573370010370 Walker B motif; other site 573370010371 Cys-rich peptide radical SAM maturase CcpM; Region: rSAM_ocin_clost; TIGR04068 573370010372 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573370010373 FeS/SAM binding site; other site 573370010374 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573370010375 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573370010376 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573370010377 Walker A/P-loop; other site 573370010378 ATP binding site [chemical binding]; other site 573370010379 Q-loop/lid; other site 573370010380 ABC transporter signature motif; other site 573370010381 Walker B; other site 573370010382 D-loop; other site 573370010383 H-loop/switch region; other site 573370010384 PUA-like domain; Region: PUA_2; pfam14306 573370010385 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 573370010386 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 573370010387 active site 573370010388 catalytic residues [active] 573370010389 DNA binding site [nucleotide binding] 573370010390 Int/Topo IB signature motif; other site 573370010391 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573370010392 active site 573370010393 DNA binding site [nucleotide binding] 573370010394 Int/Topo IB signature motif; other site 573370010395 Replicase family; Region: Replicase; pfam03090 573370010396 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 573370010397 Queuine tRNA-ribosyltransferase; Region: TGT; cl19224 573370010398 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 573370010399 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; cl19880 573370010400 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573370010401 non-specific DNA binding site [nucleotide binding]; other site 573370010402 salt bridge; other site 573370010403 sequence-specific DNA binding site [nucleotide binding]; other site 573370010404 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; cl19880 573370010405 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 573370010406 PLD-like domain; Region: PLDc_2; pfam13091 573370010407 putative active site [active] 573370010408 catalytic site [active] 573370010409 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 573370010410 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 573370010411 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 573370010412 Walker A motif; other site 573370010413 ATP binding site [chemical binding]; other site 573370010414 Walker B motif; other site 573370010415 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; cl19880 573370010416 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 573370010417 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573370010418 Zn2+ binding site [ion binding]; other site 573370010419 Mg2+ binding site [ion binding]; other site 573370010420 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 573370010421 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370010422 putative active site [active] 573370010423 heme pocket [chemical binding]; other site 573370010424 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370010425 dimer interface [polypeptide binding]; other site 573370010426 phosphorylation site [posttranslational modification] 573370010427 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370010428 ATP binding site [chemical binding]; other site 573370010429 Mg2+ binding site [ion binding]; other site 573370010430 G-X-G motif; other site 573370010431 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 573370010432 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370010433 active site 573370010434 phosphorylation site [posttranslational modification] 573370010435 intermolecular recognition site; other site 573370010436 dimerization interface [polypeptide binding]; other site 573370010437 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 573370010438 putative binding surface; other site 573370010439 active site 573370010440 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370010441 active site 573370010442 phosphorylation site [posttranslational modification] 573370010443 intermolecular recognition site; other site 573370010444 dimerization interface [polypeptide binding]; other site 573370010445 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; cl19880 573370010446 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 573370010447 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 573370010448 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 573370010449 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573370010450 FeS/SAM binding site; other site 573370010451 Domain of unknown function (DUF4416); Region: DUF4416; pfam14385 573370010452 hypothetical protein; Provisional; Region: PRK11820 573370010453 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 573370010454 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 573370010455 hypothetical protein; Provisional; Region: PRK04323 573370010456 Guanylate kinase; Region: Guanylate_kin; pfam00625 573370010457 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 573370010458 catalytic site [active] 573370010459 G-X2-G-X-G-K; other site 573370010460 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370010461 binding surface 573370010462 TPR motif; other site 573370010463 TPR repeat; Region: TPR_11; pfam13414 573370010464 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 573370010465 DHH family; Region: DHH; pfam01368 573370010466 Protein of unknown function (DUF330); Region: DUF330; pfam03886 573370010467 mce related protein; Region: MCE; pfam02470 573370010468 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 573370010469 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573370010470 Walker A/P-loop; other site 573370010471 ATP binding site [chemical binding]; other site 573370010472 Q-loop/lid; other site 573370010473 ABC transporter signature motif; other site 573370010474 Walker B; other site 573370010475 D-loop; other site 573370010476 H-loop/switch region; other site 573370010477 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 573370010478 Permease; Region: Permease; pfam02405 573370010479 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 573370010480 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 573370010481 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 573370010482 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 573370010483 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 573370010484 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370010485 active site 573370010486 phosphorylation site [posttranslational modification] 573370010487 intermolecular recognition site; other site 573370010488 dimerization interface [polypeptide binding]; other site 573370010489 LytTr DNA-binding domain; Region: LytTR; smart00850 573370010490 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 573370010491 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 573370010492 GAF domain; Region: GAF_3; pfam13492 573370010493 Histidine kinase; Region: His_kinase; pfam06580 573370010494 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370010495 ATP binding site [chemical binding]; other site 573370010496 Mg2+ binding site [ion binding]; other site 573370010497 G-X-G motif; other site 573370010498 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 573370010499 Carbon starvation protein CstA; Region: CstA; pfam02554 573370010500 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 573370010501 PAS fold; Region: PAS; pfam00989 573370010502 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370010503 putative active site [active] 573370010504 heme pocket [chemical binding]; other site 573370010505 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370010506 PAS fold; Region: PAS_3; pfam08447 573370010507 putative active site [active] 573370010508 heme pocket [chemical binding]; other site 573370010509 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 573370010510 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370010511 dimer interface [polypeptide binding]; other site 573370010512 phosphorylation site [posttranslational modification] 573370010513 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370010514 ATP binding site [chemical binding]; other site 573370010515 Mg2+ binding site [ion binding]; other site 573370010516 G-X-G motif; other site 573370010517 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370010518 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370010519 active site 573370010520 phosphorylation site [posttranslational modification] 573370010521 intermolecular recognition site; other site 573370010522 dimerization interface [polypeptide binding]; other site 573370010523 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 573370010524 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 573370010525 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573370010526 FeS/SAM binding site; other site 573370010527 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 573370010528 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 573370010529 PhoU domain; Region: PhoU; pfam01895 573370010530 PhoU domain; Region: PhoU; pfam01895 573370010531 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 573370010532 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 573370010533 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 573370010534 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573370010535 motif II; other site 573370010536 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 573370010537 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573370010538 catalytic residue [active] 573370010539 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 573370010540 dimerization interface [polypeptide binding]; other site 573370010541 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 573370010542 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 573370010543 FAD binding domain; Region: FAD_binding_4; pfam01565 573370010544 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 573370010545 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 573370010546 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 573370010547 Cysteine-rich domain; Region: CCG; pfam02754 573370010548 Cysteine-rich domain; Region: CCG; pfam02754 573370010549 Herpesvirus UL21; Region: Herpes_UL21; pfam03252 573370010550 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 573370010551 Mechanosensitive ion channel; Region: MS_channel; pfam00924 573370010552 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 573370010553 Ligand Binding Site [chemical binding]; other site 573370010554 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 573370010555 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 573370010556 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 573370010557 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 573370010558 Ligand Binding Site [chemical binding]; other site 573370010559 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 573370010560 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 573370010561 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 573370010562 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370010563 dimer interface [polypeptide binding]; other site 573370010564 phosphorylation site [posttranslational modification] 573370010565 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370010566 ATP binding site [chemical binding]; other site 573370010567 Mg2+ binding site [ion binding]; other site 573370010568 G-X-G motif; other site 573370010569 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 573370010570 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370010571 active site 573370010572 phosphorylation site [posttranslational modification] 573370010573 intermolecular recognition site; other site 573370010574 dimerization interface [polypeptide binding]; other site 573370010575 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370010576 Walker A motif; other site 573370010577 ATP binding site [chemical binding]; other site 573370010578 Walker B motif; other site 573370010579 arginine finger; other site 573370010580 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 573370010581 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 573370010582 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 573370010583 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573370010584 FeS/SAM binding site; other site 573370010585 cell division protein FtsZ; Validated; Region: PRK09330 573370010586 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 573370010587 nucleotide binding site [chemical binding]; other site 573370010588 SulA interaction site; other site 573370010589 cell division protein FtsA; Region: ftsA; TIGR01174 573370010590 Cell division protein FtsA; Region: FtsA; smart00842 573370010591 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 573370010592 nucleotide binding site [chemical binding]; other site 573370010593 Cell division protein FtsA; Region: FtsA; pfam14450 573370010594 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 573370010595 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 573370010596 UDP-N-acetylmuramate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: MurB; COG0812 573370010597 FAD binding domain; Region: FAD_binding_4; cl19922 573370010598 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 573370010599 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 573370010600 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 573370010601 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 573370010602 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 573370010603 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 573370010604 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 573370010605 active site 573370010606 homodimer interface [polypeptide binding]; other site 573370010607 cell division protein FtsW; Region: ftsW; TIGR02614 573370010608 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 573370010609 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; cl19125 573370010610 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 573370010611 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 573370010612 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 573370010613 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 573370010614 Mg++ binding site [ion binding]; other site 573370010615 putative catalytic motif [active] 573370010616 putative substrate binding site [chemical binding]; other site 573370010617 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 573370010618 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 573370010619 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 573370010620 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 573370010621 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 573370010622 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 573370010623 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 573370010624 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 573370010625 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 573370010626 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 573370010627 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 573370010628 Cell division protein FtsL; Region: FtsL; cl11433 573370010629 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 573370010630 cell division protein MraZ; Reviewed; Region: PRK00326 573370010631 MraZ protein; Region: MraZ; pfam02381 573370010632 MraZ protein; Region: MraZ; pfam02381 573370010633 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573370010634 Zn2+ binding site [ion binding]; other site 573370010635 Mg2+ binding site [ion binding]; other site 573370010636 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 573370010637 PhoU domain; Region: PhoU; pfam01895 573370010638 PhoU domain; Region: PhoU; pfam01895 573370010639 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 573370010640 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 573370010641 amphi-Trp domain; Region: amphi-Trp; TIGR04354 573370010642 XXXCH domain; Region: XXXCH_domain; TIGR04358 573370010643 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 573370010644 putative binding surface; other site 573370010645 active site 573370010646 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 573370010647 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 573370010648 putative binding surface; other site 573370010649 active site 573370010650 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 573370010651 putative binding surface; other site 573370010652 active site 573370010653 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 573370010654 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370010655 ATP binding site [chemical binding]; other site 573370010656 Mg2+ binding site [ion binding]; other site 573370010657 G-X-G motif; other site 573370010658 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 573370010659 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370010660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370010661 active site 573370010662 phosphorylation site [posttranslational modification] 573370010663 intermolecular recognition site; other site 573370010664 dimerization interface [polypeptide binding]; other site 573370010665 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 573370010666 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 573370010667 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 573370010668 P-loop; other site 573370010669 Magnesium ion binding site [ion binding]; other site 573370010670 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 573370010671 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 573370010672 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 573370010673 HEAT repeats; Region: HEAT_2; pfam13646 573370010674 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 573370010675 protein binding surface [polypeptide binding]; other site 573370010676 HEAT repeats; Region: HEAT_2; pfam13646 573370010677 HEAT repeats; Region: HEAT_2; pfam13646 573370010678 HEAT repeats; Region: HEAT_2; pfam13646 573370010679 HEAT repeats; Region: HEAT_2; pfam13646 573370010680 HEAT repeats; Region: HEAT_2; pfam13646 573370010681 HEAT repeats; Region: HEAT_2; pfam13646 573370010682 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 573370010683 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370010684 active site 573370010685 phosphorylation site [posttranslational modification] 573370010686 intermolecular recognition site; other site 573370010687 dimerization interface [polypeptide binding]; other site 573370010688 CheB methylesterase; Region: CheB_methylest; pfam01339 573370010689 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 573370010690 metal-binding site [ion binding] 573370010691 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 573370010692 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 573370010693 metal-binding site [ion binding] 573370010694 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 573370010695 Soluble P-type ATPase [General function prediction only]; Region: COG4087 573370010696 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573370010697 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573370010698 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 573370010699 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 573370010700 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 573370010701 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 573370010702 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 573370010703 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 573370010704 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 573370010705 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573370010706 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 573370010707 substrate binding pocket [chemical binding]; other site 573370010708 membrane-bound complex binding site; other site 573370010709 hinge residues; other site 573370010710 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370010711 PAS domain; Region: PAS_9; pfam13426 573370010712 putative active site [active] 573370010713 heme pocket [chemical binding]; other site 573370010714 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370010715 PAS fold; Region: PAS_3; pfam08447 573370010716 putative active site [active] 573370010717 heme pocket [chemical binding]; other site 573370010718 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 573370010719 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370010720 putative active site [active] 573370010721 heme pocket [chemical binding]; other site 573370010722 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370010723 dimer interface [polypeptide binding]; other site 573370010724 phosphorylation site [posttranslational modification] 573370010725 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370010726 ATP binding site [chemical binding]; other site 573370010727 Mg2+ binding site [ion binding]; other site 573370010728 G-X-G motif; other site 573370010729 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370010730 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370010731 active site 573370010732 phosphorylation site [posttranslational modification] 573370010733 intermolecular recognition site; other site 573370010734 dimerization interface [polypeptide binding]; other site 573370010735 LysE type translocator; Region: LysE; cl00565 573370010736 DinB family; Region: DinB; cl17821 573370010737 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 573370010738 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 573370010739 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 573370010740 Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783 573370010741 biotin synthase; Region: bioB; TIGR00433 573370010742 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 573370010743 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 573370010744 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 573370010745 HI0933-like protein; Region: HI0933_like; pfam03486 573370010746 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 573370010747 Domain of unknown function (DUF309); Region: DUF309; pfam03745 573370010748 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 573370010749 active site 573370010750 metal binding site [ion binding]; metal-binding site 573370010751 GeoRSP system radical SAM/SPASM protein; Region: GeoRSP_rSAM; TIGR04303 573370010752 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 573370010753 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 573370010754 catalytic triad [active] 573370010755 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 573370010756 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 573370010757 N-acetyl-D-glucosamine binding site [chemical binding]; other site 573370010758 catalytic residue [active] 573370010759 Domain of unknown function DUF87; Region: DUF87; pfam01935 573370010760 AAA-like domain; Region: AAA_10; pfam12846 573370010761 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370010762 active site 573370010763 phosphorylation site [posttranslational modification] 573370010764 intermolecular recognition site; other site 573370010765 dimerization interface [polypeptide binding]; other site 573370010766 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 573370010767 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370010768 putative active site [active] 573370010769 heme pocket [chemical binding]; other site 573370010770 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370010771 dimer interface [polypeptide binding]; other site 573370010772 phosphorylation site [posttranslational modification] 573370010773 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370010774 ATP binding site [chemical binding]; other site 573370010775 Mg2+ binding site [ion binding]; other site 573370010776 G-X-G motif; other site 573370010777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370010778 active site 573370010779 phosphorylation site [posttranslational modification] 573370010780 intermolecular recognition site; other site 573370010781 dimerization interface [polypeptide binding]; other site 573370010782 TPR repeat; Region: TPR_11; pfam13414 573370010783 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370010784 binding surface 573370010785 TPR motif; other site 573370010786 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370010787 binding surface 573370010788 TPR motif; other site 573370010789 TPR repeat; Region: TPR_11; pfam13414 573370010790 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 573370010791 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 573370010792 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 573370010793 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 573370010794 metal ion-dependent adhesion site (MIDAS); other site 573370010795 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 573370010796 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 573370010797 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 573370010798 ATP binding site [chemical binding]; other site 573370010799 Walker A motif; other site 573370010800 hexamer interface [polypeptide binding]; other site 573370010801 Walker B motif; other site 573370010802 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 573370010803 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 573370010804 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 573370010805 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 573370010806 BON domain; Region: BON; pfam04972 573370010807 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 573370010808 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 573370010809 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 573370010810 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370010811 active site 573370010812 phosphorylation site [posttranslational modification] 573370010813 intermolecular recognition site; other site 573370010814 dimerization interface [polypeptide binding]; other site 573370010815 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370010816 Walker A motif; other site 573370010817 ATP binding site [chemical binding]; other site 573370010818 Walker B motif; other site 573370010819 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 573370010820 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 573370010821 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573370010822 Zn2+ binding site [ion binding]; other site 573370010823 Mg2+ binding site [ion binding]; other site 573370010824 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 573370010825 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 573370010826 catalytic core [active] 573370010827 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 573370010828 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573370010829 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573370010830 putative substrate translocation pore; other site 573370010831 Predicted transcriptional regulator [Transcription]; Region: COG2932 573370010832 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573370010833 salt bridge; other site 573370010834 non-specific DNA binding site [nucleotide binding]; other site 573370010835 sequence-specific DNA binding site [nucleotide binding]; other site 573370010836 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 573370010837 Catalytic site [active] 573370010838 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 573370010839 S4 domain; Region: S4; pfam01479 573370010840 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 573370010841 active site 573370010842 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 573370010843 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 573370010844 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 573370010845 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 573370010846 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573370010847 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 573370010848 active site 573370010849 DNA binding site [nucleotide binding] 573370010850 Int/Topo IB signature motif; other site 573370010851 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 573370010852 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370010853 metal binding site [ion binding]; metal-binding site 573370010854 active site 573370010855 I-site; other site 573370010856 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 573370010857 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573370010858 Zn2+ binding site [ion binding]; other site 573370010859 Mg2+ binding site [ion binding]; other site 573370010860 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 573370010861 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 573370010862 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 573370010863 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370010864 binding surface 573370010865 TPR motif; other site 573370010866 SdiA-regulated; Region: SdiA-regulated; cl19046 573370010867 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 573370010868 Uncharacterized conserved protein [Function unknown]; Region: COG1359 573370010869 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573370010870 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 573370010871 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 573370010872 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 573370010873 HlyD family secretion protein; Region: HlyD_3; pfam13437 573370010874 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 573370010875 MMPL family; Region: MMPL; cl14618 573370010876 MMPL family; Region: MMPL; cl14618 573370010877 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 573370010878 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 573370010879 PAS domain; Region: PAS_8; pfam13188 573370010880 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370010881 ATP binding site [chemical binding]; other site 573370010882 Mg2+ binding site [ion binding]; other site 573370010883 G-X-G motif; other site 573370010884 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 573370010885 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 573370010886 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 573370010887 PYR/PP interface [polypeptide binding]; other site 573370010888 dimer interface [polypeptide binding]; other site 573370010889 TPP binding site [chemical binding]; other site 573370010890 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 573370010891 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 573370010892 TPP-binding site [chemical binding]; other site 573370010893 dimer interface [polypeptide binding]; other site 573370010894 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 573370010895 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370010896 binding surface 573370010897 TPR motif; other site 573370010898 Glycosyl transferases group 1; Region: Glycos_transf_1; cl19138 573370010899 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 573370010900 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 573370010901 tetramer interface [polypeptide binding]; other site 573370010902 heme binding pocket [chemical binding]; other site 573370010903 NADPH binding site [chemical binding]; other site 573370010904 Matrixin; Region: Peptidase_M10; pfam00413 573370010905 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 573370010906 active site 573370010907 CreA protein; Region: CreA; cl19505 573370010908 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370010909 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370010910 putative active site [active] 573370010911 heme pocket [chemical binding]; other site 573370010912 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370010913 putative active site [active] 573370010914 heme pocket [chemical binding]; other site 573370010915 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 573370010916 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370010917 putative active site [active] 573370010918 heme pocket [chemical binding]; other site 573370010919 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370010920 Walker A motif; other site 573370010921 ATP binding site [chemical binding]; other site 573370010922 Walker B motif; other site 573370010923 arginine finger; other site 573370010924 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 573370010925 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 573370010926 Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581 573370010927 Iron-sulfur protein interface; other site 573370010928 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 573370010929 proximal heme binding site [chemical binding]; other site 573370010930 distal heme binding site [chemical binding]; other site 573370010931 dimer interface [polypeptide binding]; other site 573370010932 fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626 573370010933 L-aspartate oxidase; Provisional; Region: PRK06175 573370010934 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 573370010935 fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552 573370010936 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 573370010937 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 573370010938 fumarate hydratase; Provisional; Region: PRK06246 573370010939 Fumarase C-terminus; Region: Fumerase_C; cl00795 573370010940 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 573370010941 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 573370010942 FAD binding pocket [chemical binding]; other site 573370010943 FAD binding motif [chemical binding]; other site 573370010944 phosphate binding motif [ion binding]; other site 573370010945 beta-alpha-beta structure motif; other site 573370010946 NAD binding pocket [chemical binding]; other site 573370010947 Iron coordination center [ion binding]; other site 573370010948 putative oxidoreductase; Provisional; Region: PRK12831 573370010949 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 573370010950 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 573370010951 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 573370010952 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; cl19125 573370010953 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573370010954 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 573370010955 Malic enzyme, N-terminal domain; Region: malic; pfam00390 573370010956 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 573370010957 putative NAD(P) binding site [chemical binding]; other site 573370010958 TPR repeat; Region: TPR_11; pfam13414 573370010959 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370010960 binding surface 573370010961 TPR motif; other site 573370010962 TPR repeat; Region: TPR_11; pfam13414 573370010963 CheB methylesterase; Region: CheB_methylest; pfam01339 573370010964 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 573370010965 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 573370010966 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 573370010967 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 573370010968 PAS domain; Region: PAS_10; pfam13596 573370010969 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370010970 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370010971 putative active site [active] 573370010972 heme pocket [chemical binding]; other site 573370010973 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370010974 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370010975 putative active site [active] 573370010976 heme pocket [chemical binding]; other site 573370010977 PAS domain S-box; Region: sensory_box; TIGR00229 573370010978 PAS domain; Region: PAS; smart00091 573370010979 PAS domain S-box; Region: sensory_box; TIGR00229 573370010980 PAS domain; Region: PAS; smart00091 573370010981 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370010982 heme pocket [chemical binding]; other site 573370010983 putative active site [active] 573370010984 GAF domain; Region: GAF_2; pfam13185 573370010985 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370010986 dimer interface [polypeptide binding]; other site 573370010987 phosphorylation site [posttranslational modification] 573370010988 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370010989 ATP binding site [chemical binding]; other site 573370010990 Mg2+ binding site [ion binding]; other site 573370010991 G-X-G motif; other site 573370010992 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370010993 active site 573370010994 phosphorylation site [posttranslational modification] 573370010995 intermolecular recognition site; other site 573370010996 dimerization interface [polypeptide binding]; other site 573370010997 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; cl19880 573370010998 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 573370010999 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 573370011000 trimer interface [polypeptide binding]; other site 573370011001 active site 573370011002 substrate binding site [chemical binding]; other site 573370011003 CoA binding site [chemical binding]; other site 573370011004 active site 573370011005 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 573370011006 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 573370011007 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573370011008 Radical SAM superfamily; Region: Radical_SAM; pfam04055 573370011009 FeS/SAM binding site; other site 573370011010 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 573370011011 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 573370011012 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 573370011013 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cd00397 573370011014 active site 573370011015 DNA binding site [nucleotide binding] 573370011016 Int/Topo IB signature motif; other site 573370011017 Protein of unknown function (DUF3620); Region: DUF3620; cl02233 573370011018 Helix-turn-helix domain; Region: HTH_39; pfam14090 573370011019 Eukaryotic and archaeal DNA primase small subunit; Region: DNA_primase_S; pfam01896 573370011020 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370011021 ATP binding site [chemical binding]; other site 573370011022 Walker A motif; other site 573370011023 Walker B motif; other site 573370011024 arginine finger; other site 573370011025 EVE domain; Region: EVE; cl00728 573370011026 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 573370011027 HNH endonuclease; Region: HNH_2; pfam13391 573370011028 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 573370011029 PLD-like domain; Region: PLDc_2; pfam13091 573370011030 putative active site [active] 573370011031 catalytic site [active] 573370011032 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 573370011033 hypothetical protein; Reviewed; Region: PRK12497 573370011034 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 573370011035 RNA/DNA hybrid binding site [nucleotide binding]; other site 573370011036 active site 573370011037 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 573370011038 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 573370011039 SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; pfam09936 573370011040 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 573370011041 RimM N-terminal domain; Region: RimM; pfam01782 573370011042 PRC-barrel domain; Region: PRC; pfam05239 573370011043 hypothetical protein; Provisional; Region: PRK00468 573370011044 ribosomal protein S16; Region: S16; TIGR00002 573370011045 signal recognition particle protein; Provisional; Region: PRK10867 573370011046 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 573370011047 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 573370011048 P loop; other site 573370011049 GTP binding site [chemical binding]; other site 573370011050 Signal peptide binding domain; Region: SRP_SPB; pfam02978 573370011051 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 573370011052 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 573370011053 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 573370011054 aspartate aminotransferase; Provisional; Region: PRK06836 573370011055 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573370011056 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573370011057 homodimer interface [polypeptide binding]; other site 573370011058 catalytic residue [active] 573370011059 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 573370011060 Peptidase family U32; Region: Peptidase_U32; cl03113 573370011061 AAA domain; Region: AAA_17; cl19128 573370011062 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 573370011063 catalytic core [active] 573370011064 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 573370011065 active site 573370011066 FMN binding site [chemical binding]; other site 573370011067 substrate binding site [chemical binding]; other site 573370011068 putative catalytic residue [active] 573370011069 FSIP1 family; Region: FSIP1; pfam15554 573370011070 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 573370011071 Transglycosylase; Region: Transgly; pfam00912 573370011072 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 573370011073 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 573370011074 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 573370011075 peroxiredoxin; Provisional; Region: PRK13189 573370011076 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 573370011077 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 573370011078 [Protein-PII] uridylyltransferase; Region: UTase_glnD; TIGR01693 573370011079 metal binding triad; other site 573370011080 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 573370011081 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573370011082 Zn2+ binding site [ion binding]; other site 573370011083 Mg2+ binding site [ion binding]; other site 573370011084 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 573370011085 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 573370011086 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 573370011087 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 573370011088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370011089 active site 573370011090 phosphorylation site [posttranslational modification] 573370011091 intermolecular recognition site; other site 573370011092 dimerization interface [polypeptide binding]; other site 573370011093 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370011094 PAS fold; Region: PAS_3; pfam08447 573370011095 putative active site [active] 573370011096 heme pocket [chemical binding]; other site 573370011097 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370011098 dimer interface [polypeptide binding]; other site 573370011099 phosphorylation site [posttranslational modification] 573370011100 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 573370011101 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 573370011102 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 573370011103 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 573370011104 catalytic core [active] 573370011105 FOG: CBS domain [General function prediction only]; Region: COG0517 573370011106 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 573370011107 FOG: CBS domain [General function prediction only]; Region: COG0517 573370011108 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 573370011109 FOG: CBS domain [General function prediction only]; Region: COG0517 573370011110 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 573370011111 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370011112 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370011113 putative active site [active] 573370011114 heme pocket [chemical binding]; other site 573370011115 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370011116 putative active site [active] 573370011117 heme pocket [chemical binding]; other site 573370011118 PAS domain; Region: PAS_9; pfam13426 573370011119 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370011120 dimer interface [polypeptide binding]; other site 573370011121 phosphorylation site [posttranslational modification] 573370011122 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370011123 ATP binding site [chemical binding]; other site 573370011124 Mg2+ binding site [ion binding]; other site 573370011125 G-X-G motif; other site 573370011126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370011127 active site 573370011128 phosphorylation site [posttranslational modification] 573370011129 intermolecular recognition site; other site 573370011130 dimerization interface [polypeptide binding]; other site 573370011131 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 573370011132 putative binding surface; other site 573370011133 active site 573370011134 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573370011135 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573370011136 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 573370011137 putative ADP-binding pocket [chemical binding]; other site 573370011138 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573370011139 mercuric reductase; Validated; Region: PRK06370 573370011140 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 573370011141 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573370011142 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 573370011143 Methyltransferase FkbM domain; Region: Methyltransf_21; pfam05050 573370011144 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 573370011145 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 573370011146 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573370011147 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 573370011148 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 573370011149 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 573370011150 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 573370011151 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 573370011152 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 573370011153 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 573370011154 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 573370011155 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370011156 dimer interface [polypeptide binding]; other site 573370011157 phosphorylation site [posttranslational modification] 573370011158 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370011159 ATP binding site [chemical binding]; other site 573370011160 Mg2+ binding site [ion binding]; other site 573370011161 G-X-G motif; other site 573370011162 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370011163 active site 573370011164 phosphorylation site [posttranslational modification] 573370011165 intermolecular recognition site; other site 573370011166 dimerization interface [polypeptide binding]; other site 573370011167 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370011168 active site 573370011169 phosphorylation site [posttranslational modification] 573370011170 intermolecular recognition site; other site 573370011171 dimerization interface [polypeptide binding]; other site 573370011172 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 573370011173 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 573370011174 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 573370011175 Sel1-like repeats; Region: SEL1; smart00671 573370011176 Sel1-like repeats; Region: SEL1; smart00671 573370011177 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 573370011178 Sel1-like repeats; Region: SEL1; smart00671 573370011179 Sel1-like repeats; Region: SEL1; smart00671 573370011180 Sel1-like repeats; Region: SEL1; smart00671 573370011181 Sel1-like repeats; Region: SEL1; smart00671 573370011182 MoxR-like ATPases [General function prediction only]; Region: COG0714 573370011183 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370011184 Walker A motif; other site 573370011185 ATP binding site [chemical binding]; other site 573370011186 Walker B motif; other site 573370011187 arginine finger; other site 573370011188 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573370011189 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573370011190 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370011191 TPR motif; other site 573370011192 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573370011193 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370011194 dimer interface [polypeptide binding]; other site 573370011195 phosphorylation site [posttranslational modification] 573370011196 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370011197 ATP binding site [chemical binding]; other site 573370011198 Mg2+ binding site [ion binding]; other site 573370011199 G-X-G motif; other site 573370011200 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 573370011201 Protein of unknown function DUF58; Region: DUF58; pfam01882 573370011202 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 573370011203 metal ion-dependent adhesion site (MIDAS); other site 573370011204 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 573370011205 metal ion-dependent adhesion site (MIDAS); other site 573370011206 von Willebrand factor type A domain; Region: VWA_2; pfam13519 573370011207 metal ion-dependent adhesion site (MIDAS); other site 573370011208 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573370011209 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370011210 binding surface 573370011211 TPR motif; other site 573370011212 Oxygen tolerance; Region: BatD; pfam13584 573370011213 Bacterial SH3 domain; Region: SH3_3; pfam08239 573370011214 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 573370011215 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 573370011216 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 573370011217 Uncharacterized conserved protein [Function unknown]; Region: COG3287 573370011218 FIST N domain; Region: FIST; pfam08495 573370011219 FIST C domain; Region: FIST_C; pfam10442 573370011220 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 573370011221 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 573370011222 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 573370011223 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 573370011224 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 573370011225 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 573370011226 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 573370011227 putative FMN binding site [chemical binding]; other site 573370011228 Predicted transcriptional regulators [Transcription]; Region: COG1733 573370011229 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 573370011230 dimer interface [polypeptide binding]; other site 573370011231 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 573370011232 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 573370011233 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370011234 metal binding site [ion binding]; metal-binding site 573370011235 active site 573370011236 I-site; other site 573370011237 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 573370011238 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 573370011239 ligand binding site [chemical binding]; other site 573370011240 flexible hinge region; other site 573370011241 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 573370011242 putative switch regulator; other site 573370011243 non-specific DNA interactions [nucleotide binding]; other site 573370011244 DNA binding site [nucleotide binding] 573370011245 sequence specific DNA binding site [nucleotide binding]; other site 573370011246 putative cAMP binding site [chemical binding]; other site 573370011247 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 573370011248 Ferredoxin [Energy production and conversion]; Region: COG1146 573370011249 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 573370011250 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 573370011251 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 573370011252 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 573370011253 twin arginine translocase protein A; Provisional; Region: tatA; PRK02958 573370011254 Cache domain; Region: Cache_1; pfam02743 573370011255 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370011256 dimerization interface [polypeptide binding]; other site 573370011257 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370011258 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573370011259 dimer interface [polypeptide binding]; other site 573370011260 putative CheW interface [polypeptide binding]; other site 573370011261 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 573370011262 cubane metal cluster [ion binding]; other site 573370011263 hybrid metal cluster; other site 573370011264 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 573370011265 4Fe-4S binding domain; Region: Fer4_6; pfam12837 573370011266 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 573370011267 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 573370011268 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370011269 metal binding site [ion binding]; metal-binding site 573370011270 active site 573370011271 I-site; other site 573370011272 Protein of unknown function (DUF1501); Region: DUF1501; cl19855 573370011273 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 573370011274 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 573370011275 putative active site pocket [active] 573370011276 dimerization interface [polypeptide binding]; other site 573370011277 putative catalytic residue [active] 573370011278 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 573370011279 Ligand binding site; other site 573370011280 Putative Catalytic site; other site 573370011281 DXD motif; other site 573370011282 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 573370011283 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 573370011284 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 573370011285 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354 573370011286 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 573370011287 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370011288 active site 573370011289 phosphorylation site [posttranslational modification] 573370011290 intermolecular recognition site; other site 573370011291 dimerization interface [polypeptide binding]; other site 573370011292 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573370011293 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370011294 dimer interface [polypeptide binding]; other site 573370011295 phosphorylation site [posttranslational modification] 573370011296 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370011297 ATP binding site [chemical binding]; other site 573370011298 Mg2+ binding site [ion binding]; other site 573370011299 G-X-G motif; other site 573370011300 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 573370011301 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370011302 active site 573370011303 phosphorylation site [posttranslational modification] 573370011304 intermolecular recognition site; other site 573370011305 dimerization interface [polypeptide binding]; other site 573370011306 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573370011307 Zn2+ binding site [ion binding]; other site 573370011308 Mg2+ binding site [ion binding]; other site 573370011309 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 573370011310 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 573370011311 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 573370011312 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 573370011313 Soluble P-type ATPase [General function prediction only]; Region: COG4087 573370011314 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 573370011315 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 573370011316 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 573370011317 Surface antigen; Region: Bac_surface_Ag; pfam01103 573370011318 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 573370011319 Family of unknown function (DUF490); Region: DUF490; pfam04357 573370011320 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830 573370011321 active site 573370011322 ADP/pyrophosphate binding site [chemical binding]; other site 573370011323 dimerization interface [polypeptide binding]; other site 573370011324 allosteric effector site; other site 573370011325 fructose-1,6-bisphosphate binding site; other site 573370011326 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 573370011327 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 573370011328 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573370011329 DNA-binding site [nucleotide binding]; DNA binding site 573370011330 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573370011331 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573370011332 homodimer interface [polypeptide binding]; other site 573370011333 catalytic residue [active] 573370011334 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 573370011335 anti sigma factor interaction site; other site 573370011336 regulatory phosphorylation site [posttranslational modification]; other site 573370011337 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370011338 active site 573370011339 phosphorylation site [posttranslational modification] 573370011340 intermolecular recognition site; other site 573370011341 dimerization interface [polypeptide binding]; other site 573370011342 PAS domain S-box; Region: sensory_box; TIGR00229 573370011343 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370011344 putative active site [active] 573370011345 heme pocket [chemical binding]; other site 573370011346 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 573370011347 FtsJ-like methyltransferase; Region: FtsJ; cl17430 573370011348 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 573370011349 DAK2 domain; Region: Dak2; cl03685 573370011350 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 573370011351 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 573370011352 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 573370011353 dimerization domain swap beta strand [polypeptide binding]; other site 573370011354 regulatory protein interface [polypeptide binding]; other site 573370011355 active site 573370011356 regulatory phosphorylation site [posttranslational modification]; other site 573370011357 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 573370011358 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 573370011359 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 573370011360 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 573370011361 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370011362 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 573370011363 putative active site [active] 573370011364 heme pocket [chemical binding]; other site 573370011365 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370011366 dimer interface [polypeptide binding]; other site 573370011367 phosphorylation site [posttranslational modification] 573370011368 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370011369 ATP binding site [chemical binding]; other site 573370011370 Mg2+ binding site [ion binding]; other site 573370011371 G-X-G motif; other site 573370011372 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370011373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370011374 active site 573370011375 phosphorylation site [posttranslational modification] 573370011376 intermolecular recognition site; other site 573370011377 dimerization interface [polypeptide binding]; other site 573370011378 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 573370011379 MMPL family; Region: MMPL; cl14618 573370011380 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 573370011381 MMPL family; Region: MMPL; cl14618 573370011382 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 573370011383 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 573370011384 HlyD family secretion protein; Region: HlyD_3; pfam13437 573370011385 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 573370011386 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 573370011387 Mechanosensitive ion channel; Region: MS_channel; pfam00924 573370011388 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 573370011389 Domain of unknown function (DUF362); Region: DUF362; cl19822 573370011390 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 573370011391 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 573370011392 Cytochrome c; Region: Cytochrom_C; pfam00034 573370011393 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 573370011394 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 573370011395 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 573370011396 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370011397 S-adenosylmethionine binding site [chemical binding]; other site 573370011398 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 573370011399 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838 573370011400 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 573370011401 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 573370011402 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 573370011403 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 573370011404 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 573370011405 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 573370011406 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 573370011407 substrate binding pocket [chemical binding]; other site 573370011408 chain length determination region; other site 573370011409 substrate-Mg2+ binding site; other site 573370011410 catalytic residues [active] 573370011411 aspartate-rich region 1; other site 573370011412 active site lid residues [active] 573370011413 aspartate-rich region 2; other site 573370011414 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 573370011415 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 573370011416 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 573370011417 dimerization interface [polypeptide binding]; other site 573370011418 ATP binding site [chemical binding]; other site 573370011419 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 573370011420 dimerization interface [polypeptide binding]; other site 573370011421 ATP binding site [chemical binding]; other site 573370011422 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 573370011423 PAS domain; Region: PAS_9; pfam13426 573370011424 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370011425 putative active site [active] 573370011426 heme pocket [chemical binding]; other site 573370011427 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370011428 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573370011429 dimer interface [polypeptide binding]; other site 573370011430 putative CheW interface [polypeptide binding]; other site 573370011431 Rubredoxin [Energy production and conversion]; Region: COG1773 573370011432 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 573370011433 iron binding site [ion binding]; other site 573370011434 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 573370011435 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 573370011436 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 573370011437 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 573370011438 trimer interface [polypeptide binding]; other site 573370011439 putative Zn binding site [ion binding]; other site 573370011440 Transposase; Region: DEDD_Tnp_IS110; pfam01548 573370011441 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 573370011442 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 573370011443 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573370011444 Walker B; other site 573370011445 D-loop; other site 573370011446 H-loop/switch region; other site 573370011447 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 573370011448 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 573370011449 active site 573370011450 metal binding site [ion binding]; metal-binding site 573370011451 AAA domain; Region: AAA_23; pfam13476 573370011452 Walker A/P-loop; other site 573370011453 ATP binding site [chemical binding]; other site 573370011454 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 573370011455 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573370011456 Zn2+ binding site [ion binding]; other site 573370011457 Mg2+ binding site [ion binding]; other site 573370011458 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 573370011459 synthetase active site [active] 573370011460 NTP binding site [chemical binding]; other site 573370011461 metal binding site [ion binding]; metal-binding site 573370011462 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 573370011463 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 573370011464 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 573370011465 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 573370011466 peptide binding site [polypeptide binding]; other site 573370011467 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 573370011468 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 573370011469 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573370011470 ATP binding site [chemical binding]; other site 573370011471 putative Mg++ binding site [ion binding]; other site 573370011472 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573370011473 nucleotide binding region [chemical binding]; other site 573370011474 ATP-binding site [chemical binding]; other site 573370011475 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 573370011476 Subtilase family; Region: Peptidase_S8; pfam00082 573370011477 active site 573370011478 catalytic residues [active] 573370011479 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370011480 S-adenosylmethionine binding site [chemical binding]; other site 573370011481 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 573370011482 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG3366 573370011483 Nucleoside recognition; Region: Gate; pfam07670 573370011484 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 573370011485 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 573370011486 active site 573370011487 catalytic residues [active] 573370011488 DNA binding site [nucleotide binding] 573370011489 Int/Topo IB signature motif; other site 573370011490 Domain of unknown function (DUF927); Region: DUF927; cl12098 573370011491 DNA methylase; Region: N6_N4_Mtase; cl17433 573370011492 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 573370011493 PHP domain; Region: PHP; pfam02811 573370011494 active site 573370011495 AAA domain; Region: AAA_23; pfam13476 573370011496 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573370011497 ABC transporter signature motif; other site 573370011498 Walker B; other site 573370011499 D-loop; other site 573370011500 H-loop/switch region; other site 573370011501 conserved hypothetical protein; Region: Lon_rel_chp; TIGR02653 573370011502 Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337 573370011503 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 573370011504 TIGR02687 family protein; Region: TIGR02687 573370011505 PglZ domain; Region: PglZ; pfam08665 573370011506 Cytochrome C biogenesis protein; Region: CcmH; cl01179 573370011507 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 573370011508 Methyltransferase domain; Region: Methyltransf_26; pfam13659 573370011509 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 573370011510 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 573370011511 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 573370011512 PLD-like domain; Region: PLDc_2; pfam13091 573370011513 putative active site [active] 573370011514 catalytic site [active] 573370011515 Staphylococcal nuclease homologues; Region: SNc; smart00318 573370011516 Staphylococcal nuclease homologue; Region: SNase; cl00140 573370011517 AAA ATPase domain; Region: AAA_15; pfam13175 573370011518 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 573370011519 Walker B; other site 573370011520 D-loop; other site 573370011521 H-loop/switch region; other site 573370011522 Soluble P-type ATPase [General function prediction only]; Region: COG4087 573370011523 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; cl19880 573370011524 Beta subunit of integration host factor (IHFB); Region: IHF_B; cd13836 573370011525 dimer interface [polypeptide binding]; other site 573370011526 DNA binding site [nucleotide binding] 573370011527 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 573370011528 active site 573370011529 DNA binding site [nucleotide binding] 573370011530 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 573370011531 catalytic site [active] 573370011532 phenylalanyl-tRNA synthetase subunit alpha; Provisional; Region: pheS; PRK04172 573370011533 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 573370011534 putative active site pocket [active] 573370011535 dimerization interface [polypeptide binding]; other site 573370011536 putative catalytic residue [active] 573370011537 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 573370011538 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 573370011539 catalytic residues [active] 573370011540 catalytic nucleophile [active] 573370011541 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 573370011542 Presynaptic Site I dimer interface [polypeptide binding]; other site 573370011543 catalytic residues [active] 573370011544 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 573370011545 Synaptic Flat tetramer interface [polypeptide binding]; other site 573370011546 Synaptic Site I dimer interface [polypeptide binding]; other site 573370011547 DNA binding site [nucleotide binding] 573370011548 YcgL domain; Region: YcgL; cl01189 573370011549 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 573370011550 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 573370011551 Helix-hairpin-helix containing domain; Region: HHH_4; pfam14490 573370011552 AAA domain; Region: AAA_30; pfam13604 573370011553 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 573370011554 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 573370011555 GIY-YIG motif/motif A; other site 573370011556 putative active site [active] 573370011557 putative metal binding site [ion binding]; other site 573370011558 SEC-C motif; Region: SEC-C; cl19389 573370011559 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370011560 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370011561 putative active site [active] 573370011562 heme pocket [chemical binding]; other site 573370011563 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370011564 metal binding site [ion binding]; metal-binding site 573370011565 active site 573370011566 I-site; other site 573370011567 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 573370011568 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370011569 metal binding site [ion binding]; metal-binding site 573370011570 active site 573370011571 I-site; other site 573370011572 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 573370011573 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 573370011574 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573370011575 non-specific DNA binding site [nucleotide binding]; other site 573370011576 salt bridge; other site 573370011577 sequence-specific DNA binding site [nucleotide binding]; other site 573370011578 Domain of unknown function (DUF955); Region: DUF955; cl01076 573370011579 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; cl19880 573370011580 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 573370011581 PAS domain; Region: PAS_8; pfam13188 573370011582 PAS domain; Region: PAS_9; pfam13426 573370011583 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573370011584 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370011585 ATP binding site [chemical binding]; other site 573370011586 Mg2+ binding site [ion binding]; other site 573370011587 G-X-G motif; other site 573370011588 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370011589 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370011590 active site 573370011591 phosphorylation site [posttranslational modification] 573370011592 intermolecular recognition site; other site 573370011593 dimerization interface [polypeptide binding]; other site 573370011594 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370011595 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573370011596 dimer interface [polypeptide binding]; other site 573370011597 putative CheW interface [polypeptide binding]; other site 573370011598 Hemerythrin; Region: Hemerythrin; cd12107 573370011599 Fe binding site [ion binding]; other site 573370011600 potential frameshift: common BLAST hit: gi|170744450|ref|YP_001773105.1| integrase catalytic region 573370011601 Integrase core domain; Region: rve; pfam00665 573370011602 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 573370011603 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 573370011604 CheB methylesterase; Region: CheB_methylest; pfam01339 573370011605 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 573370011606 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 573370011607 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 573370011608 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 573370011609 PAS domain; Region: PAS_10; pfam13596 573370011610 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370011611 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370011612 putative active site [active] 573370011613 heme pocket [chemical binding]; other site 573370011614 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370011615 dimer interface [polypeptide binding]; other site 573370011616 phosphorylation site [posttranslational modification] 573370011617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370011618 ATP binding site [chemical binding]; other site 573370011619 Mg2+ binding site [ion binding]; other site 573370011620 G-X-G motif; other site 573370011621 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370011622 active site 573370011623 phosphorylation site [posttranslational modification] 573370011624 intermolecular recognition site; other site 573370011625 dimerization interface [polypeptide binding]; other site 573370011626 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370011627 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370011628 putative active site [active] 573370011629 heme pocket [chemical binding]; other site 573370011630 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370011631 putative active site [active] 573370011632 heme pocket [chemical binding]; other site 573370011633 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370011634 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370011635 putative active site [active] 573370011636 heme pocket [chemical binding]; other site 573370011637 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370011638 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370011639 putative active site [active] 573370011640 heme pocket [chemical binding]; other site 573370011641 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370011642 putative active site [active] 573370011643 heme pocket [chemical binding]; other site 573370011644 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370011645 metal binding site [ion binding]; metal-binding site 573370011646 active site 573370011647 I-site; other site 573370011648 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 573370011649 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370011650 active site 573370011651 phosphorylation site [posttranslational modification] 573370011652 intermolecular recognition site; other site 573370011653 dimerization interface [polypeptide binding]; other site 573370011654 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573370011655 Zn2+ binding site [ion binding]; other site 573370011656 Mg2+ binding site [ion binding]; other site 573370011657 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573370011658 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 573370011659 substrate binding pocket [chemical binding]; other site 573370011660 membrane-bound complex binding site; other site 573370011661 hinge residues; other site 573370011662 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370011663 dimer interface [polypeptide binding]; other site 573370011664 phosphorylation site [posttranslational modification] 573370011665 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370011666 ATP binding site [chemical binding]; other site 573370011667 Mg2+ binding site [ion binding]; other site 573370011668 G-X-G motif; other site 573370011669 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370011670 active site 573370011671 phosphorylation site [posttranslational modification] 573370011672 intermolecular recognition site; other site 573370011673 dimerization interface [polypeptide binding]; other site 573370011674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370011675 active site 573370011676 phosphorylation site [posttranslational modification] 573370011677 intermolecular recognition site; other site 573370011678 dimerization interface [polypeptide binding]; other site 573370011679 Hemerythrin; Region: Hemerythrin; cd12107 573370011680 Fe binding site [ion binding]; other site 573370011681 Hemerythrin; Region: Hemerythrin; cd12107 573370011682 Fe binding site [ion binding]; other site 573370011683 Domain of unknown function (DUF4268); Region: DUF4268; pfam14088 573370011684 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 573370011685 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 573370011686 active site 573370011687 Phage protein Gp37/Gp68; Region: Gp37_Gp68; pfam07505 573370011688 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 573370011689 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 573370011690 active site 573370011691 catalytic residues [active] 573370011692 DNA binding site [nucleotide binding] 573370011693 Int/Topo IB signature motif; other site 573370011694 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573370011695 active site 573370011696 DNA binding site [nucleotide binding] 573370011697 Int/Topo IB signature motif; other site 573370011698 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573370011699 Walker A/P-loop; other site 573370011700 ATP binding site [chemical binding]; other site 573370011701 Q-loop/lid; other site 573370011702 replication factor C large subunit; Provisional; Region: PRK04195 573370011703 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 573370011704 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 573370011705 HSP70 interaction site [polypeptide binding]; other site 573370011706 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 573370011707 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 573370011708 putative active site [active] 573370011709 DEAD-like helicases superfamily; Region: DEXDc; smart00487 573370011710 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573370011711 ATP binding site [chemical binding]; other site 573370011712 putative Mg++ binding site [ion binding]; other site 573370011713 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573370011714 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 573370011715 ATP-binding site [chemical binding]; other site 573370011716 Uncharacterized integral membrane protein [Function unknown]; Region: COG5594 573370011717 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370011718 binding surface 573370011719 TPR motif; other site 573370011720 TPR repeat; Region: TPR_11; pfam13414 573370011721 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370011722 binding surface 573370011723 TPR motif; other site 573370011724 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573370011725 TPR repeat; Region: TPR_11; pfam13414 573370011726 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370011727 binding surface 573370011728 TPR motif; other site 573370011729 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370011730 metal binding site [ion binding]; metal-binding site 573370011731 active site 573370011732 I-site; other site 573370011733 serine O-acetyltransferase; Region: cysE; TIGR01172 573370011734 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 573370011735 trimer interface [polypeptide binding]; other site 573370011736 active site 573370011737 substrate binding site [chemical binding]; other site 573370011738 CoA binding site [chemical binding]; other site 573370011739 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 573370011740 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 573370011741 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 573370011742 XdhC Rossmann domain; Region: XdhC_C; pfam13478 573370011743 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 573370011744 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573370011745 catalytic residue [active] 573370011746 quinolinate synthetase; Provisional; Region: PRK09375 573370011747 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 573370011748 CPxP motif; other site 573370011749 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 573370011750 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 573370011751 ATP binding site [chemical binding]; other site 573370011752 substrate interface [chemical binding]; other site 573370011753 cysteine synthase; Region: PLN02565 573370011754 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 573370011755 dimer interface [polypeptide binding]; other site 573370011756 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573370011757 catalytic residue [active] 573370011758 biotin synthase; Provisional; Region: PRK07094 573370011759 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573370011760 FeS/SAM binding site; other site 573370011761 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 573370011762 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 573370011763 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573370011764 Walker A/P-loop; other site 573370011765 ATP binding site [chemical binding]; other site 573370011766 Q-loop/lid; other site 573370011767 ABC transporter signature motif; other site 573370011768 Walker B; other site 573370011769 D-loop; other site 573370011770 H-loop/switch region; other site 573370011771 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 573370011772 homodimer interface [polypeptide binding]; other site 573370011773 substrate-cofactor binding pocket; other site 573370011774 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573370011775 catalytic residue [active] 573370011776 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 573370011777 homodimer interface [polypeptide binding]; other site 573370011778 substrate-cofactor binding pocket; other site 573370011779 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573370011780 catalytic residue [active] 573370011781 Predicted transcriptional regulator [Transcription]; Region: COG1959 573370011782 Rrf2 family protein; Region: rrf2_super; TIGR00738 573370011783 multiple promoter invertase; Provisional; Region: mpi; PRK13413 573370011784 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 573370011785 catalytic residues [active] 573370011786 catalytic nucleophile [active] 573370011787 Presynaptic Site I dimer interface [polypeptide binding]; other site 573370011788 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 573370011789 Synaptic Flat tetramer interface [polypeptide binding]; other site 573370011790 Synaptic Site I dimer interface [polypeptide binding]; other site 573370011791 DNA binding site [nucleotide binding] 573370011792 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 573370011793 DNA-binding interface [nucleotide binding]; DNA binding site 573370011794 Chromate resistance exported protein; Region: Chrome_Resist; cl01744 573370011795 Uncharacterized protein containing a ferredoxin domain (DUF2148); Region: DUF2148; cl19624 573370011796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573370011797 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573370011798 putative substrate translocation pore; other site 573370011799 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573370011800 Zn2+ binding site [ion binding]; other site 573370011801 Mg2+ binding site [ion binding]; other site 573370011802 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573370011803 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573370011804 putative substrate translocation pore; other site 573370011805 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 573370011806 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 573370011807 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 573370011808 active site residue [active] 573370011809 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 573370011810 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 573370011811 Chromate transporter; Region: Chromate_transp; pfam02417 573370011812 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 573370011813 dimer interface [polypeptide binding]; other site 573370011814 Methyltransferase domain; Region: Methyltransf_31; pfam13847 573370011815 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370011816 S-adenosylmethionine binding site [chemical binding]; other site 573370011817 potential frameshift: common BLAST hit: gi|73668872|ref|YP_304887.1| transposase 573370011818 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573370011819 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 573370011820 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 573370011821 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 573370011822 RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637 573370011823 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573370011824 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573370011825 DNA binding residues [nucleotide binding] 573370011826 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 573370011827 Ligand Binding Site [chemical binding]; other site 573370011828 tetrathionate reductase subunit A; Provisional; Region: PRK14991 573370011829 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 573370011830 molybdopterin cofactor binding site; other site 573370011831 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 573370011832 putative molybdopterin cofactor binding site; other site 573370011833 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 573370011834 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 573370011835 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 573370011836 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573370011837 dimerization interface [polypeptide binding]; other site 573370011838 putative DNA binding site [nucleotide binding]; other site 573370011839 putative Zn2+ binding site [ion binding]; other site 573370011840 arsenical-resistance protein; Region: acr3; TIGR00832 573370011841 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573370011842 dimerization interface [polypeptide binding]; other site 573370011843 putative DNA binding site [nucleotide binding]; other site 573370011844 putative Zn2+ binding site [ion binding]; other site 573370011845 DGC domain; Region: DGC; pfam08859 573370011846 Predicted permeases [General function prediction only]; Region: COG0701 573370011847 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 573370011848 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 573370011849 catalytic residues [active] 573370011850 Sulfite exporter TauE/SafE; Region: TauE; cl19196 573370011851 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 573370011852 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 573370011853 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 573370011854 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 573370011855 [4Fe-4S] binding site [ion binding]; other site 573370011856 molybdopterin cofactor binding site; other site 573370011857 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 573370011858 molybdopterin cofactor binding site; other site 573370011859 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 573370011860 potential protein location (hypothetical protein DMR_37480 [Desulfovibrio magneticus RS-1]) that overlaps RNA (23S ribosomal RNA) 573370011861 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 573370011862 PAS domain S-box; Region: sensory_box; TIGR00229 573370011863 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370011864 putative active site [active] 573370011865 heme pocket [chemical binding]; other site 573370011866 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370011867 metal binding site [ion binding]; metal-binding site 573370011868 active site 573370011869 I-site; other site 573370011870 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 573370011871 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573370011872 ATP-grasp domain; Region: ATP-grasp; pfam02222 573370011873 GTPase RsgA; Reviewed; Region: PRK01889 573370011874 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 573370011875 GTPase/Zn-binding domain interface [polypeptide binding]; other site 573370011876 GTP/Mg2+ binding site [chemical binding]; other site 573370011877 G4 box; other site 573370011878 G5 box; other site 573370011879 G1 box; other site 573370011880 Switch I region; other site 573370011881 G2 box; other site 573370011882 G3 box; other site 573370011883 Switch II region; other site 573370011884 Predicted acetyltransferase [General function prediction only]; Region: COG3153 573370011885 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 573370011886 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 573370011887 AP (apurinic/apyrimidinic) site pocket; other site 573370011888 DNA interaction; other site 573370011889 Metal-binding active site; metal-binding site 573370011890 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 573370011891 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 573370011892 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 573370011893 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 573370011894 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 573370011895 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 573370011896 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 573370011897 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 573370011898 putative active site [active] 573370011899 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573370011900 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573370011901 Walker A/P-loop; other site 573370011902 ATP binding site [chemical binding]; other site 573370011903 Q-loop/lid; other site 573370011904 ABC transporter signature motif; other site 573370011905 Walker B; other site 573370011906 D-loop; other site 573370011907 H-loop/switch region; other site 573370011908 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 573370011909 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370011910 Walker A motif; other site 573370011911 ATP binding site [chemical binding]; other site 573370011912 Walker B motif; other site 573370011913 arginine finger; other site 573370011914 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 573370011915 Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596 573370011916 PAS domain S-box; Region: sensory_box; TIGR00229 573370011917 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370011918 putative active site [active] 573370011919 heme pocket [chemical binding]; other site 573370011920 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370011921 PAS fold; Region: PAS_3; pfam08447 573370011922 putative active site [active] 573370011923 heme pocket [chemical binding]; other site 573370011924 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370011925 dimer interface [polypeptide binding]; other site 573370011926 phosphorylation site [posttranslational modification] 573370011927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370011928 ATP binding site [chemical binding]; other site 573370011929 Mg2+ binding site [ion binding]; other site 573370011930 G-X-G motif; other site 573370011931 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370011932 active site 573370011933 phosphorylation site [posttranslational modification] 573370011934 intermolecular recognition site; other site 573370011935 dimerization interface [polypeptide binding]; other site 573370011936 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 573370011937 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370011938 active site 573370011939 phosphorylation site [posttranslational modification] 573370011940 intermolecular recognition site; other site 573370011941 dimerization interface [polypeptide binding]; other site 573370011942 HD domain; Region: HD_5; pfam13487 573370011943 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370011944 active site 573370011945 phosphorylation site [posttranslational modification] 573370011946 intermolecular recognition site; other site 573370011947 dimerization interface [polypeptide binding]; other site 573370011948 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 573370011949 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573370011950 Zn2+ binding site [ion binding]; other site 573370011951 Mg2+ binding site [ion binding]; other site 573370011952 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 573370011953 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 573370011954 NLPC_P60 stabilizing domain, N term; Region: N_NLPC_P60; pfam12912 573370011955 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 573370011956 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 573370011957 NlpC/P60 family; Region: NLPC_P60; cl17555 573370011958 Protein of unknown function DUF45; Region: DUF45; pfam01863 573370011959 ribonuclease R; Region: RNase_R; TIGR02063 573370011960 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 573370011961 RNB domain; Region: RNB; pfam00773 573370011962 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 573370011963 RNA binding site [nucleotide binding]; other site 573370011964 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 573370011965 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 573370011966 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370011967 dimerization interface [polypeptide binding]; other site 573370011968 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 573370011969 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370011970 putative active site [active] 573370011971 heme pocket [chemical binding]; other site 573370011972 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370011973 dimer interface [polypeptide binding]; other site 573370011974 phosphorylation site [posttranslational modification] 573370011975 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370011976 ATP binding site [chemical binding]; other site 573370011977 Mg2+ binding site [ion binding]; other site 573370011978 G-X-G motif; other site 573370011979 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 573370011980 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 573370011981 ligand binding site [chemical binding]; other site 573370011982 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370011983 PAS fold; Region: PAS_3; pfam08447 573370011984 putative active site [active] 573370011985 heme pocket [chemical binding]; other site 573370011986 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 573370011987 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370011988 dimer interface [polypeptide binding]; other site 573370011989 phosphorylation site [posttranslational modification] 573370011990 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370011991 ATP binding site [chemical binding]; other site 573370011992 Mg2+ binding site [ion binding]; other site 573370011993 G-X-G motif; other site 573370011994 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370011995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370011996 active site 573370011997 phosphorylation site [posttranslational modification] 573370011998 intermolecular recognition site; other site 573370011999 dimerization interface [polypeptide binding]; other site 573370012000 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370012001 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370012002 active site 573370012003 phosphorylation site [posttranslational modification] 573370012004 intermolecular recognition site; other site 573370012005 dimerization interface [polypeptide binding]; other site 573370012006 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573370012007 DNA binding site [nucleotide binding] 573370012008 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 573370012009 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370012010 dimerization interface [polypeptide binding]; other site 573370012011 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370012012 dimer interface [polypeptide binding]; other site 573370012013 phosphorylation site [posttranslational modification] 573370012014 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370012015 ATP binding site [chemical binding]; other site 573370012016 Mg2+ binding site [ion binding]; other site 573370012017 G-X-G motif; other site 573370012018 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 573370012019 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370012020 dimerization interface [polypeptide binding]; other site 573370012021 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370012022 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573370012023 dimer interface [polypeptide binding]; other site 573370012024 putative CheW interface [polypeptide binding]; other site 573370012025 Predicted transcriptional regulators [Transcription]; Region: COG1733 573370012026 dimerization interface [polypeptide binding]; other site 573370012027 putative DNA binding site [nucleotide binding]; other site 573370012028 putative Zn2+ binding site [ion binding]; other site 573370012029 SnoaL-like domain; Region: SnoaL_2; pfam12680 573370012030 short chain dehydrogenase; Provisional; Region: PRK06523 573370012031 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573370012032 NAD(P) binding site [chemical binding]; other site 573370012033 active site 573370012034 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 573370012035 active site 573370012036 dimer interface [polypeptide binding]; other site 573370012037 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 573370012038 hinge region; other site 573370012039 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 573370012040 putative nucleotide binding site [chemical binding]; other site 573370012041 uridine monophosphate binding site [chemical binding]; other site 573370012042 homohexameric interface [polypeptide binding]; other site 573370012043 elongation factor Ts; Reviewed; Region: tsf; PRK12332 573370012044 UBA/TS-N domain; Region: UBA; pfam00627 573370012045 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 573370012046 rRNA interaction site [nucleotide binding]; other site 573370012047 S8 interaction site; other site 573370012048 putative laminin-1 binding site; other site 573370012049 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 573370012050 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 573370012051 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 573370012052 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 573370012053 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 573370012054 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 573370012055 putative acyl-acceptor binding pocket; other site 573370012056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370012057 active site 573370012058 phosphorylation site [posttranslational modification] 573370012059 intermolecular recognition site; other site 573370012060 dimerization interface [polypeptide binding]; other site 573370012061 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 573370012062 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 573370012063 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573370012064 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573370012065 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370012066 S-adenosylmethionine binding site [chemical binding]; other site 573370012067 NNMT/PNMT/TEMT family; Region: NNMT_PNMT_TEMT; pfam01234 573370012068 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 573370012069 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 573370012070 metal-binding site 573370012071 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573370012072 active site 573370012073 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 573370012074 putative dimer interface [polypeptide binding]; other site 573370012075 active site pocket [active] 573370012076 putative cataytic base [active] 573370012077 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 573370012078 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830 573370012079 active site 573370012080 ADP/pyrophosphate binding site [chemical binding]; other site 573370012081 dimerization interface [polypeptide binding]; other site 573370012082 allosteric effector site; other site 573370012083 fructose-1,6-bisphosphate binding site; other site 573370012084 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573370012085 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573370012086 The first cupredoxin domain of bacteria two domain multicopper oxidase; Region: CuRO_1_2dMco_1; cd13860 573370012087 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 573370012088 putative trimer interface [polypeptide binding]; other site 573370012089 trinuclear Cu binding site [ion binding]; other site 573370012090 The second cupredoxin domain of bacterial two domain multicopper oxidase McoN and similar proteins; Region: CuRO_D2_2dMcoN_like; cd04202 573370012091 trimer interface [polypeptide binding]; other site 573370012092 trinuclear Cu binding site [ion binding]; other site 573370012093 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 573370012094 Outer membrane efflux protein; Region: OEP; pfam02321 573370012095 Outer membrane efflux protein; Region: OEP; pfam02321 573370012096 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 573370012097 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573370012098 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573370012099 homodimer interface [polypeptide binding]; other site 573370012100 catalytic residue [active] 573370012101 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 573370012102 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 573370012103 trmE is a tRNA modification GTPase; Region: trmE; cd04164 573370012104 G1 box; other site 573370012105 GTP/Mg2+ binding site [chemical binding]; other site 573370012106 Switch I region; other site 573370012107 G2 box; other site 573370012108 Switch II region; other site 573370012109 G3 box; other site 573370012110 G4 box; other site 573370012111 G5 box; other site 573370012112 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 573370012113 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370012114 binding surface 573370012115 TPR motif; other site 573370012116 TPR repeat; Region: TPR_11; pfam13414 573370012117 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573370012118 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 573370012119 NAD(P) binding site [chemical binding]; other site 573370012120 active site 573370012121 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 573370012122 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 573370012123 NAD binding site [chemical binding]; other site 573370012124 homotetramer interface [polypeptide binding]; other site 573370012125 homodimer interface [polypeptide binding]; other site 573370012126 active site 573370012127 substrate binding site [chemical binding]; other site 573370012128 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573370012129 active site 573370012130 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 573370012131 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 573370012132 B12 binding site [chemical binding]; other site 573370012133 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 573370012134 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 573370012135 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573370012136 active site 573370012137 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 573370012138 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 573370012139 Ligand binding site; other site 573370012140 Putative Catalytic site; other site 573370012141 DXD motif; other site 573370012142 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 573370012143 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 573370012144 NAD binding site [chemical binding]; other site 573370012145 putative substrate binding site 2 [chemical binding]; other site 573370012146 putative substrate binding site 1 [chemical binding]; other site 573370012147 active site 573370012148 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 573370012149 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370012150 S-adenosylmethionine binding site [chemical binding]; other site 573370012151 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 573370012152 active site 573370012153 catalytic triad [active] 573370012154 oxyanion hole [active] 573370012155 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573370012156 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573370012157 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573370012158 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 573370012159 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573370012160 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573370012161 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 573370012162 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573370012163 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 573370012164 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 573370012165 active site 573370012166 catalytic triad [active] 573370012167 oxyanion hole [active] 573370012168 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 573370012169 RNase_H superfamily; Region: RNase_H_2; pfam13482 573370012170 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 573370012171 Methyltransferase domain; Region: Methyltransf_26; pfam13659 573370012172 phage shock protein C; Region: phageshock_pspC; TIGR02978 573370012173 PspC domain; Region: PspC; pfam04024 573370012174 Phage shock protein B; Region: PspB; cl05946 573370012175 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 573370012176 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370012177 dimerization interface [polypeptide binding]; other site 573370012178 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370012179 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 573370012180 dimer interface [polypeptide binding]; other site 573370012181 putative CheW interface [polypeptide binding]; other site 573370012182 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 573370012183 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 573370012184 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 573370012185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370012186 Walker A motif; other site 573370012187 ATP binding site [chemical binding]; other site 573370012188 Walker B motif; other site 573370012189 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 573370012190 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 573370012191 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 573370012192 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 573370012193 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 573370012194 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 573370012195 putative ADP-ribose binding site [chemical binding]; other site 573370012196 putative active site [active] 573370012197 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 573370012198 active site 573370012199 HslU subunit interaction site [polypeptide binding]; other site 573370012200 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 573370012201 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370012202 Walker A motif; other site 573370012203 ATP binding site [chemical binding]; other site 573370012204 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370012205 Walker B motif; other site 573370012206 arginine finger; other site 573370012207 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 573370012208 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 573370012209 homohexameric interface [polypeptide binding]; other site 573370012210 feedback inhibition sensing region; other site 573370012211 nucleotide binding site [chemical binding]; other site 573370012212 N-acetyl-L-glutamate binding site [chemical binding]; other site 573370012213 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 573370012214 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573370012215 active site 573370012216 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 573370012217 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370012218 active site 573370012219 phosphorylation site [posttranslational modification] 573370012220 intermolecular recognition site; other site 573370012221 dimerization interface [polypeptide binding]; other site 573370012222 GAF domain; Region: GAF_2; pfam13185 573370012223 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 573370012224 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573370012225 Autoinducer binding domain; Region: Autoind_bind; pfam03472 573370012226 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573370012227 DNA binding residues [nucleotide binding] 573370012228 dimerization interface [polypeptide binding]; other site 573370012229 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 573370012230 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 573370012231 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 573370012232 dimer interface [polypeptide binding]; other site 573370012233 putative anticodon binding site; other site 573370012234 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 573370012235 motif 1; other site 573370012236 active site 573370012237 motif 2; other site 573370012238 motif 3; other site 573370012239 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 573370012240 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573370012241 FtsX-like permease family; Region: FtsX; pfam02687 573370012242 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 573370012243 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 573370012244 Walker A/P-loop; other site 573370012245 ATP binding site [chemical binding]; other site 573370012246 Q-loop/lid; other site 573370012247 ABC transporter signature motif; other site 573370012248 Walker B; other site 573370012249 D-loop; other site 573370012250 H-loop/switch region; other site 573370012251 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 573370012252 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 573370012253 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 573370012254 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 573370012255 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 573370012256 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 573370012257 Surface antigen; Region: Bac_surface_Ag; pfam01103 573370012258 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 573370012259 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 573370012260 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 573370012261 DsrE/DsrF-like family; Region: DrsE; pfam02635 573370012262 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370012263 PAS domain; Region: PAS_9; pfam13426 573370012264 putative active site [active] 573370012265 heme pocket [chemical binding]; other site 573370012266 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370012267 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 573370012268 Walker A motif; other site 573370012269 ATP binding site [chemical binding]; other site 573370012270 Walker B motif; other site 573370012271 arginine finger; other site 573370012272 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 573370012273 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 573370012274 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 573370012275 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 573370012276 ligand binding site [chemical binding]; other site 573370012277 flexible hinge region; other site 573370012278 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 573370012279 putative switch regulator; other site 573370012280 non-specific DNA interactions [nucleotide binding]; other site 573370012281 DNA binding site [nucleotide binding] 573370012282 sequence specific DNA binding site [nucleotide binding]; other site 573370012283 putative cAMP binding site [chemical binding]; other site 573370012284 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 573370012285 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 573370012286 ligand binding site [chemical binding]; other site 573370012287 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK06995 573370012288 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 573370012289 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 573370012290 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 573370012291 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370012292 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573370012293 putative active site [active] 573370012294 heme pocket [chemical binding]; other site 573370012295 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370012296 dimer interface [polypeptide binding]; other site 573370012297 phosphorylation site [posttranslational modification] 573370012298 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370012299 ATP binding site [chemical binding]; other site 573370012300 Mg2+ binding site [ion binding]; other site 573370012301 G-X-G motif; other site 573370012302 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370012303 active site 573370012304 phosphorylation site [posttranslational modification] 573370012305 intermolecular recognition site; other site 573370012306 dimerization interface [polypeptide binding]; other site 573370012307 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 573370012308 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 573370012309 Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or...; Region: DSPc; cl00053 573370012310 Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453 573370012311 active site 573370012312 catalytic residues [active] 573370012313 MltA specific insert domain; Region: MltA; smart00925 573370012314 3D domain; Region: 3D; cl01439 573370012315 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370012316 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370012317 active site 573370012318 phosphorylation site [posttranslational modification] 573370012319 intermolecular recognition site; other site 573370012320 dimerization interface [polypeptide binding]; other site 573370012321 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 573370012322 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 573370012323 anti sigma factor interaction site; other site 573370012324 regulatory phosphorylation site [posttranslational modification]; other site 573370012325 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370012326 active site 573370012327 phosphorylation site [posttranslational modification] 573370012328 intermolecular recognition site; other site 573370012329 dimerization interface [polypeptide binding]; other site 573370012330 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573370012331 Zn2+ binding site [ion binding]; other site 573370012332 Mg2+ binding site [ion binding]; other site 573370012333 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370012334 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370012335 putative active site [active] 573370012336 heme pocket [chemical binding]; other site 573370012337 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 573370012338 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370012339 putative active site [active] 573370012340 heme pocket [chemical binding]; other site 573370012341 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370012342 ATP binding site [chemical binding]; other site 573370012343 Mg2+ binding site [ion binding]; other site 573370012344 G-X-G motif; other site 573370012345 Predicted transcriptional regulator [Transcription]; Region: COG1959 573370012346 Rrf2 family protein; Region: rrf2_super; TIGR00738 573370012347 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370012348 active site 573370012349 phosphorylation site [posttranslational modification] 573370012350 intermolecular recognition site; other site 573370012351 dimerization interface [polypeptide binding]; other site 573370012352 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 573370012353 CHASE domain; Region: CHASE; cl01369 573370012354 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370012355 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370012356 putative active site [active] 573370012357 heme pocket [chemical binding]; other site 573370012358 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370012359 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370012360 putative active site [active] 573370012361 heme pocket [chemical binding]; other site 573370012362 PAS domain; Region: PAS; smart00091 573370012363 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 573370012364 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370012365 putative active site [active] 573370012366 heme pocket [chemical binding]; other site 573370012367 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370012368 putative active site [active] 573370012369 heme pocket [chemical binding]; other site 573370012370 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370012371 dimer interface [polypeptide binding]; other site 573370012372 phosphorylation site [posttranslational modification] 573370012373 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370012374 ATP binding site [chemical binding]; other site 573370012375 Mg2+ binding site [ion binding]; other site 573370012376 G-X-G motif; other site 573370012377 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 573370012378 PIN domain; Region: PIN_Smg5-Smg6-like; cd09880 573370012379 putative active site [active] 573370012380 PhoH-like protein; Region: PhoH; cl17668 573370012381 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 573370012382 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573370012383 dimer interface [polypeptide binding]; other site 573370012384 conserved gate region; other site 573370012385 putative PBP binding loops; other site 573370012386 ABC-ATPase subunit interface; other site 573370012387 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 573370012388 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573370012389 dimer interface [polypeptide binding]; other site 573370012390 conserved gate region; other site 573370012391 putative PBP binding loops; other site 573370012392 ABC-ATPase subunit interface; other site 573370012393 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 573370012394 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 573370012395 substrate binding site [chemical binding]; other site 573370012396 hexamer interface [polypeptide binding]; other site 573370012397 metal binding site [ion binding]; metal-binding site 573370012398 PAS domain; Region: PAS; smart00091 573370012399 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370012400 PAS domain; Region: PAS; smart00091 573370012401 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370012402 dimer interface [polypeptide binding]; other site 573370012403 phosphorylation site [posttranslational modification] 573370012404 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370012405 ATP binding site [chemical binding]; other site 573370012406 Mg2+ binding site [ion binding]; other site 573370012407 G-X-G motif; other site 573370012408 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370012409 active site 573370012410 phosphorylation site [posttranslational modification] 573370012411 intermolecular recognition site; other site 573370012412 dimerization interface [polypeptide binding]; other site 573370012413 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 573370012414 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 573370012415 NADP binding site [chemical binding]; other site 573370012416 active site 573370012417 putative substrate binding site [chemical binding]; other site 573370012418 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 573370012419 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 573370012420 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 573370012421 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 573370012422 TM-ABC transporter signature motif; other site 573370012423 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 573370012424 TM-ABC transporter signature motif; other site 573370012425 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 573370012426 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 573370012427 putative ligand binding site [chemical binding]; other site 573370012428 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 573370012429 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 573370012430 active site 573370012431 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 573370012432 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 573370012433 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 573370012434 N-acetyl-D-glucosamine binding site [chemical binding]; other site 573370012435 catalytic residue [active] 573370012436 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573370012437 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573370012438 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573370012439 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 573370012440 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573370012441 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573370012442 periplasmic folding chaperone; Provisional; Region: PRK10788 573370012443 SurA N-terminal domain; Region: SurA_N_3; cl07813 573370012444 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 573370012445 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 573370012446 aconitate hydratase; Validated; Region: PRK07229 573370012447 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 573370012448 substrate binding site [chemical binding]; other site 573370012449 ligand binding site [chemical binding]; other site 573370012450 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 573370012451 substrate binding site [chemical binding]; other site 573370012452 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 573370012453 dimer interface [polypeptide binding]; other site 573370012454 FMN binding site [chemical binding]; other site 573370012455 Uncharacterized conserved protein [Function unknown]; Region: COG2353 573370012456 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370012457 putative active site [active] 573370012458 heme pocket [chemical binding]; other site 573370012459 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573370012460 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370012461 dimer interface [polypeptide binding]; other site 573370012462 phosphorylation site [posttranslational modification] 573370012463 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370012464 ATP binding site [chemical binding]; other site 573370012465 Mg2+ binding site [ion binding]; other site 573370012466 G-X-G motif; other site 573370012467 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 573370012468 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 573370012469 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370012470 Walker A motif; other site 573370012471 ATP binding site [chemical binding]; other site 573370012472 Walker B motif; other site 573370012473 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 573370012474 GAF domain; Region: GAF_2; pfam13185 573370012475 GAF domain; Region: GAF_2; pfam13185 573370012476 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 573370012477 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370012478 dimer interface [polypeptide binding]; other site 573370012479 phosphorylation site [posttranslational modification] 573370012480 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370012481 ATP binding site [chemical binding]; other site 573370012482 Mg2+ binding site [ion binding]; other site 573370012483 G-X-G motif; other site 573370012484 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370012485 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370012486 active site 573370012487 phosphorylation site [posttranslational modification] 573370012488 intermolecular recognition site; other site 573370012489 dimerization interface [polypeptide binding]; other site 573370012490 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 573370012491 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370012492 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 573370012493 Haemolytic domain; Region: Haemolytic; pfam01809 573370012494 DsrE/DsrF-like family; Region: DrsE; cl00672 573370012495 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 573370012496 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 573370012497 substrate binding site; other site 573370012498 tetramer interface; other site 573370012499 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 573370012500 MPT binding site; other site 573370012501 trimer interface [polypeptide binding]; other site 573370012502 Tetratricopeptide repeat; Region: TPR_16; pfam13432 573370012503 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370012504 binding surface 573370012505 TPR motif; other site 573370012506 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 573370012507 PAS fold; Region: PAS_4; pfam08448 573370012508 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370012509 putative active site [active] 573370012510 heme pocket [chemical binding]; other site 573370012511 PAS domain S-box; Region: sensory_box; TIGR00229 573370012512 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370012513 putative active site [active] 573370012514 heme pocket [chemical binding]; other site 573370012515 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370012516 putative active site [active] 573370012517 heme pocket [chemical binding]; other site 573370012518 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573370012519 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370012520 dimer interface [polypeptide binding]; other site 573370012521 phosphorylation site [posttranslational modification] 573370012522 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370012523 ATP binding site [chemical binding]; other site 573370012524 Mg2+ binding site [ion binding]; other site 573370012525 G-X-G motif; other site 573370012526 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370012527 active site 573370012528 response regulator PleD; Reviewed; Region: pleD; PRK09581 573370012529 phosphorylation site [posttranslational modification] 573370012530 intermolecular recognition site; other site 573370012531 dimerization interface [polypeptide binding]; other site 573370012532 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370012533 metal binding site [ion binding]; metal-binding site 573370012534 active site 573370012535 I-site; other site 573370012536 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370012537 S-adenosylmethionine binding site [chemical binding]; other site 573370012538 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 573370012539 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 573370012540 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 573370012541 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 573370012542 oligomer interface [polypeptide binding]; other site 573370012543 metal binding site [ion binding]; metal-binding site 573370012544 metal binding site [ion binding]; metal-binding site 573370012545 Cl binding site [ion binding]; other site 573370012546 aspartate ring; other site 573370012547 basic sphincter; other site 573370012548 putative hydrophobic gate; other site 573370012549 periplasmic entrance; other site 573370012550 cytidylate kinase; Provisional; Region: cmk; PRK00023 573370012551 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 573370012552 CMP-binding site; other site 573370012553 The sites determining sugar specificity; other site 573370012554 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 573370012555 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573370012556 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573370012557 homodimer interface [polypeptide binding]; other site 573370012558 catalytic residue [active] 573370012559 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 573370012560 Ligand Binding Site [chemical binding]; other site 573370012561 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 573370012562 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 573370012563 Cache domain; Region: Cache_1; pfam02743 573370012564 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370012565 dimerization interface [polypeptide binding]; other site 573370012566 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370012567 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573370012568 dimer interface [polypeptide binding]; other site 573370012569 putative CheW interface [polypeptide binding]; other site 573370012570 Transcriptional regulators [Transcription]; Region: MarR; COG1846 573370012571 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573370012572 putative DNA binding site [nucleotide binding]; other site 573370012573 putative Zn2+ binding site [ion binding]; other site 573370012574 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 573370012575 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 573370012576 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370012577 S-adenosylmethionine binding site [chemical binding]; other site 573370012578 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 573370012579 active site 573370012580 metal binding site [ion binding]; metal-binding site 573370012581 HD domain; Region: HD_3; pfam13023 573370012582 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 573370012583 heterotetramer interface [polypeptide binding]; other site 573370012584 active site pocket [active] 573370012585 cleavage site 573370012586 EF-hand domain pair; Region: EF-hand_7; pfam13499 573370012587 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 573370012588 Ca2+ binding site [ion binding]; other site 573370012589 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370012590 TPR motif; other site 573370012591 binding surface 573370012592 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370012593 TPR repeat; Region: TPR_11; pfam13414 573370012594 binding surface 573370012595 TPR motif; other site 573370012596 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 573370012597 NAD(P) binding site [chemical binding]; other site 573370012598 catalytic residues [active] 573370012599 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 573370012600 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573370012601 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573370012602 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 573370012603 dimerization interface [polypeptide binding]; other site 573370012604 Putative ammonia monooxygenase; Region: AmoA; pfam05145 573370012605 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 573370012606 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 573370012607 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 573370012608 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 573370012609 Catalytic site [active] 573370012610 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 573370012611 GTP-binding protein LepA; Provisional; Region: PRK05433 573370012612 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 573370012613 G1 box; other site 573370012614 putative GEF interaction site [polypeptide binding]; other site 573370012615 GTP/Mg2+ binding site [chemical binding]; other site 573370012616 Switch I region; other site 573370012617 G2 box; other site 573370012618 G3 box; other site 573370012619 Switch II region; other site 573370012620 G4 box; other site 573370012621 G5 box; other site 573370012622 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 573370012623 Elongation Factor G, domain II; Region: EFG_II; pfam14492 573370012624 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 573370012625 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 573370012626 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 573370012627 ATP-sulfurylase; Region: ATPS; cd00517 573370012628 active site 573370012629 HXXH motif; other site 573370012630 flexible loop; other site 573370012631 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573370012632 dimerization interface [polypeptide binding]; other site 573370012633 putative DNA binding site [nucleotide binding]; other site 573370012634 putative Zn2+ binding site [ion binding]; other site 573370012635 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 573370012636 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 573370012637 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 573370012638 Part of AAA domain; Region: AAA_19; pfam13245 573370012639 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 573370012640 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 573370012641 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 573370012642 Walker A motif; other site 573370012643 ATP binding site [chemical binding]; other site 573370012644 Walker B motif; other site 573370012645 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 573370012646 DHH family; Region: DHH; pfam01368 573370012647 Catalytic domain of Protein Kinases; Region: PKc; cd00180 573370012648 active site 573370012649 ATP binding site [chemical binding]; other site 573370012650 substrate binding site [chemical binding]; other site 573370012651 activation loop (A-loop); other site 573370012652 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 573370012653 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 573370012654 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 573370012655 trimer interface [polypeptide binding]; other site 573370012656 active site 573370012657 substrate binding site [chemical binding]; other site 573370012658 CoA binding site [chemical binding]; other site 573370012659 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 573370012660 active site 573370012661 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 573370012662 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 573370012663 Putative zinc- or iron-chelating domain; Region: CxxCxxCC; cl00497 573370012664 NIMA-related protein kinase; Provisional; Region: PTZ00267 573370012665 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370012666 TPR motif; other site 573370012667 TPR repeat; Region: TPR_11; pfam13414 573370012668 binding surface 573370012669 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370012670 binding surface 573370012671 TPR motif; other site 573370012672 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573370012673 Tetratricopeptide repeat; Region: TPR_19; pfam14559 573370012674 HEAT-like repeat; Region: HEAT_EZ; pfam13513 573370012675 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 573370012676 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573370012677 substrate binding pocket [chemical binding]; other site 573370012678 membrane-bound complex binding site; other site 573370012679 hinge residues; other site 573370012680 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573370012681 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370012682 dimer interface [polypeptide binding]; other site 573370012683 phosphorylation site [posttranslational modification] 573370012684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370012685 ATP binding site [chemical binding]; other site 573370012686 Mg2+ binding site [ion binding]; other site 573370012687 G-X-G motif; other site 573370012688 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 573370012689 active site 573370012690 metal binding site [ion binding]; metal-binding site 573370012691 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases [Signal transduction mechanisms]; Region: ApaH; COG0639 573370012692 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 573370012693 nudix motif; other site 573370012694 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 573370012695 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 573370012696 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 573370012697 protein binding site [polypeptide binding]; other site 573370012698 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 573370012699 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 573370012700 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 573370012701 putative dimer interface [polypeptide binding]; other site 573370012702 Trm112p-like protein; Region: Trm112p; cl01066 573370012703 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 573370012704 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 573370012705 active site 573370012706 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 573370012707 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 573370012708 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 573370012709 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 573370012710 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 573370012711 ligand binding site [chemical binding]; other site 573370012712 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 573370012713 PAS fold; Region: PAS_3; pfam08447 573370012714 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370012715 heme pocket [chemical binding]; other site 573370012716 putative active site [active] 573370012717 PAS domain S-box; Region: sensory_box; TIGR00229 573370012718 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370012719 dimer interface [polypeptide binding]; other site 573370012720 phosphorylation site [posttranslational modification] 573370012721 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370012722 ATP binding site [chemical binding]; other site 573370012723 Mg2+ binding site [ion binding]; other site 573370012724 G-X-G motif; other site 573370012725 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370012726 active site 573370012727 phosphorylation site [posttranslational modification] 573370012728 intermolecular recognition site; other site 573370012729 dimerization interface [polypeptide binding]; other site 573370012730 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573370012731 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 573370012732 substrate binding pocket [chemical binding]; other site 573370012733 membrane-bound complex binding site; other site 573370012734 hinge residues; other site 573370012735 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 573370012736 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573370012737 dimer interface [polypeptide binding]; other site 573370012738 conserved gate region; other site 573370012739 ABC-ATPase subunit interface; other site 573370012740 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 573370012741 catalytic residues [active] 573370012742 Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977 573370012743 thymidylate kinase; Validated; Region: tmk; PRK00698 573370012744 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 573370012745 TMP-binding site; other site 573370012746 ATP-binding site [chemical binding]; other site 573370012747 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 573370012748 generic binding surface I; other site 573370012749 generic binding surface II; other site 573370012750 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 573370012751 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573370012752 Zn2+ binding site [ion binding]; other site 573370012753 Mg2+ binding site [ion binding]; other site 573370012754 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 573370012755 response regulator PleD; Reviewed; Region: pleD; PRK09581 573370012756 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370012757 active site 573370012758 phosphorylation site [posttranslational modification] 573370012759 intermolecular recognition site; other site 573370012760 dimerization interface [polypeptide binding]; other site 573370012761 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370012762 metal binding site [ion binding]; metal-binding site 573370012763 active site 573370012764 I-site; other site 573370012765 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 573370012766 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 573370012767 Wnt and FGF inhibitory regulator; Region: Shisa; pfam13908 573370012768 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 573370012769 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 573370012770 active site 573370012771 HIGH motif; other site 573370012772 KMSKS motif; other site 573370012773 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 573370012774 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 573370012775 putative active site [active] 573370012776 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 573370012777 Domain of unknown function DUF21; Region: DUF21; pfam01595 573370012778 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 573370012779 Transporter associated domain; Region: CorC_HlyC; smart01091 573370012780 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 573370012781 CoenzymeA binding site [chemical binding]; other site 573370012782 subunit interaction site [polypeptide binding]; other site 573370012783 PHB binding site; other site 573370012784 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 573370012785 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 573370012786 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 573370012787 putative phosphate acyltransferase; Provisional; Region: PRK05331 573370012788 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 573370012789 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 573370012790 dimer interface [polypeptide binding]; other site 573370012791 active site 573370012792 CoA binding pocket [chemical binding]; other site 573370012793 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 573370012794 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 573370012795 NAD(P) binding site [chemical binding]; other site 573370012796 homotetramer interface [polypeptide binding]; other site 573370012797 homodimer interface [polypeptide binding]; other site 573370012798 active site 573370012799 acyl carrier protein; Provisional; Region: acpP; PRK00982 573370012800 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 573370012801 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 573370012802 dimer interface [polypeptide binding]; other site 573370012803 active site 573370012804 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 573370012805 dimer interface [polypeptide binding]; other site 573370012806 active site 573370012807 glycine-pyridoxal phosphate binding site [chemical binding]; other site 573370012808 folate binding site [chemical binding]; other site 573370012809 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 573370012810 Predicted transcriptional regulators [Transcription]; Region: COG1733 573370012811 dimerization interface [polypeptide binding]; other site 573370012812 putative DNA binding site [nucleotide binding]; other site 573370012813 putative Zn2+ binding site [ion binding]; other site 573370012814 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 573370012815 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 573370012816 NADP binding site [chemical binding]; other site 573370012817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370012818 active site 573370012819 phosphorylation site [posttranslational modification] 573370012820 intermolecular recognition site; other site 573370012821 dimerization interface [polypeptide binding]; other site 573370012822 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573370012823 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 573370012824 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370012825 ATP binding site [chemical binding]; other site 573370012826 Mg2+ binding site [ion binding]; other site 573370012827 G-X-G motif; other site 573370012828 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370012829 active site 573370012830 phosphorylation site [posttranslational modification] 573370012831 intermolecular recognition site; other site 573370012832 dimerization interface [polypeptide binding]; other site 573370012833 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370012834 active site 573370012835 phosphorylation site [posttranslational modification] 573370012836 intermolecular recognition site; other site 573370012837 dimerization interface [polypeptide binding]; other site 573370012838 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370012839 dimer interface [polypeptide binding]; other site 573370012840 phosphorylation site [posttranslational modification] 573370012841 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370012842 ATP binding site [chemical binding]; other site 573370012843 Mg2+ binding site [ion binding]; other site 573370012844 G-X-G motif; other site 573370012845 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370012846 PAS domain; Region: PAS_9; pfam13426 573370012847 putative active site [active] 573370012848 heme pocket [chemical binding]; other site 573370012849 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370012850 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 573370012851 Walker A motif; other site 573370012852 ATP binding site [chemical binding]; other site 573370012853 Walker B motif; other site 573370012854 Predicted permeases [General function prediction only]; Region: COG0730 573370012855 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 573370012856 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370012857 Walker A motif; other site 573370012858 ATP binding site [chemical binding]; other site 573370012859 Walker B motif; other site 573370012860 arginine finger; other site 573370012861 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 573370012862 FecR protein; Region: FecR; pfam04773 573370012863 TPR repeat; Region: TPR_11; pfam13414 573370012864 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370012865 binding surface 573370012866 TPR motif; other site 573370012867 TPR repeat; Region: TPR_11; pfam13414 573370012868 LPP20 lipoprotein; Region: LPP20; pfam02169 573370012869 CHASE2 domain; Region: CHASE2; pfam05226 573370012870 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 573370012871 cyclase homology domain; Region: CHD; cd07302 573370012872 nucleotidyl binding site; other site 573370012873 metal binding site [ion binding]; metal-binding site 573370012874 dimer interface [polypeptide binding]; other site 573370012875 Cache domain; Region: Cache_1; pfam02743 573370012876 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370012877 dimerization interface [polypeptide binding]; other site 573370012878 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 573370012879 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370012880 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573370012881 dimer interface [polypeptide binding]; other site 573370012882 putative CheW interface [polypeptide binding]; other site 573370012883 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 573370012884 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573370012885 putative substrate translocation pore; other site 573370012886 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573370012887 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 573370012888 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 573370012889 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 573370012890 NAD(P) binding site [chemical binding]; other site 573370012891 homodimer interface [polypeptide binding]; other site 573370012892 substrate binding site [chemical binding]; other site 573370012893 active site 573370012894 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 573370012895 inhibitor-cofactor binding pocket; inhibition site 573370012896 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573370012897 catalytic residue [active] 573370012898 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 573370012899 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 573370012900 active site 573370012901 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 573370012902 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; cl19502 573370012903 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 573370012904 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 573370012905 active site 573370012906 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 573370012907 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573370012908 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 573370012909 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573370012910 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 573370012911 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 573370012912 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 573370012913 Probable Catalytic site; other site 573370012914 metal-binding site 573370012915 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 573370012916 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370012917 S-adenosylmethionine binding site [chemical binding]; other site 573370012918 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 573370012919 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 573370012920 putative ADP-binding pocket [chemical binding]; other site 573370012921 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 573370012922 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370012923 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370012924 S-adenosylmethionine binding site [chemical binding]; other site 573370012925 multiple promoter invertase; Provisional; Region: mpi; PRK13413 573370012926 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 573370012927 catalytic residues [active] 573370012928 catalytic nucleophile [active] 573370012929 Presynaptic Site I dimer interface [polypeptide binding]; other site 573370012930 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 573370012931 Synaptic Flat tetramer interface [polypeptide binding]; other site 573370012932 Synaptic Site I dimer interface [polypeptide binding]; other site 573370012933 DNA binding site [nucleotide binding] 573370012934 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569 573370012935 DNA-binding interface [nucleotide binding]; DNA binding site 573370012936 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 573370012937 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 573370012938 NAD binding site [chemical binding]; other site 573370012939 substrate binding site [chemical binding]; other site 573370012940 active site 573370012941 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 573370012942 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 573370012943 active site 573370012944 Substrate binding site; other site 573370012945 Mg++ binding site; other site 573370012946 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 573370012947 inhibitor-cofactor binding pocket; inhibition site 573370012948 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573370012949 catalytic residue [active] 573370012950 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 573370012951 WbqC-like protein family; Region: WbqC; pfam08889 573370012952 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573370012953 Coenzyme A binding pocket [chemical binding]; other site 573370012954 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573370012955 FeS/SAM binding site; other site 573370012956 Iron-sulfur cluster-binding domain; Region: SPASM; pfam13186 573370012957 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 573370012958 active site 573370012959 cosubstrate binding site; other site 573370012960 substrate binding site [chemical binding]; other site 573370012961 catalytic site [active] 573370012962 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573370012963 FeS/SAM binding site; other site 573370012964 Iron-sulfur cluster-binding domain; Region: SPASM; pfam13186 573370012965 Methyltransferase domain; Region: Methyltransf_11; pfam08241 573370012966 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 573370012967 NeuB family; Region: NeuB; pfam03102 573370012968 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 573370012969 NeuB binding interface [polypeptide binding]; other site 573370012970 putative substrate binding site [chemical binding]; other site 573370012971 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573370012972 active site 573370012973 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 573370012974 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 573370012975 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 573370012976 GSCFA family; Region: GSCFA; pfam08885 573370012977 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370012978 S-adenosylmethionine binding site [chemical binding]; other site 573370012979 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573370012980 active site 573370012981 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 573370012982 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 573370012983 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 573370012984 inhibitor-cofactor binding pocket; inhibition site 573370012985 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573370012986 catalytic residue [active] 573370012987 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573370012988 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 573370012989 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573370012990 FeS/SAM binding site; other site 573370012991 Iron-sulfur cluster-binding domain; Region: SPASM; pfam13186 573370012992 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573370012993 putative substrate translocation pore; other site 573370012994 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573370012995 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573370012996 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573370012997 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 573370012998 putative cation:proton antiport protein; Provisional; Region: PRK10669 573370012999 TrkA-N domain; Region: TrkA_N; pfam02254 573370013000 Ion channel; Region: Ion_trans_2; pfam07885 573370013001 TrkA-N domain; Region: TrkA_N; pfam02254 573370013002 TrkA-C domain; Region: TrkA_C; pfam02080 573370013003 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 573370013004 TrkA-N domain; Region: TrkA_N; pfam02254 573370013005 TrkA-C domain; Region: TrkA_C; pfam02080 573370013006 Protein of unknown function (DUF3124); Region: DUF3124; pfam11322 573370013007 tellurium resistance terB-like protein; Region: terB_like; cd07177 573370013008 metal binding site [ion binding]; metal-binding site 573370013009 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 573370013010 Vesiculovirus phosphoprotein; Region: Phosphoprotein; pfam00922 573370013011 putative transposase OrfB; Reviewed; Region: PHA02517 573370013012 HTH-like domain; Region: HTH_21; pfam13276 573370013013 Integrase core domain; Region: rve; pfam00665 573370013014 Integrase core domain; Region: rve_3; pfam13683 573370013015 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 573370013016 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573370013017 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 573370013018 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 573370013019 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 573370013020 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573370013021 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 573370013022 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 573370013023 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cd00397 573370013024 active site 573370013025 DNA binding site [nucleotide binding] 573370013026 Int/Topo IB signature motif; other site 573370013027 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573370013028 metabolite-proton symporter; Region: 2A0106; TIGR00883 573370013029 putative substrate translocation pore; other site 573370013030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370013031 active site 573370013032 phosphorylation site [posttranslational modification] 573370013033 intermolecular recognition site; other site 573370013034 dimerization interface [polypeptide binding]; other site 573370013035 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 573370013036 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370013037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370013038 active site 573370013039 phosphorylation site [posttranslational modification] 573370013040 intermolecular recognition site; other site 573370013041 dimerization interface [polypeptide binding]; other site 573370013042 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 573370013043 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 573370013044 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 573370013045 ligand binding site [chemical binding]; other site 573370013046 hypothetical protein; Provisional; Region: PRK11281 573370013047 K+ potassium transporter; Region: K_trans; pfam02705 573370013048 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370013049 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 573370013050 Walker A motif; other site 573370013051 ATP binding site [chemical binding]; other site 573370013052 Walker B motif; other site 573370013053 arginine finger; other site 573370013054 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 573370013055 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573370013056 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573370013057 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 573370013058 anti sigma factor interaction site; other site 573370013059 regulatory phosphorylation site [posttranslational modification]; other site 573370013060 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 573370013061 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 573370013062 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 573370013063 HEAT repeats; Region: HEAT_2; pfam13646 573370013064 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 573370013065 HEAT repeats; Region: HEAT_2; pfam13646 573370013066 protein binding surface [polypeptide binding]; other site 573370013067 Mu-like prophage I protein; Region: Mu-like_Pro; cl19864 573370013068 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 573370013069 cell shape determining protein, MreB/Mrl family; Region: mreB; TIGR00904 573370013070 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573370013071 nucleotide binding site [chemical binding]; other site 573370013072 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 573370013073 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 573370013074 FeoA domain; Region: FeoA; pfam04023 573370013075 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 573370013076 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 573370013077 G1 box; other site 573370013078 GTP/Mg2+ binding site [chemical binding]; other site 573370013079 G2 box; other site 573370013080 Switch I region; other site 573370013081 G3 box; other site 573370013082 Switch II region; other site 573370013083 G4 box; other site 573370013084 Nucleoside recognition; Region: Gate; pfam07670 573370013085 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 573370013086 Nucleoside recognition; Region: Gate; pfam07670 573370013087 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 573370013088 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 573370013089 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 573370013090 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 573370013091 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 573370013092 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 573370013093 ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163 573370013094 4Fe-4S binding domain; Region: Fer4_5; pfam12801 573370013095 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 573370013096 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 573370013097 Fungal domain of unknown function (DUF1750); Region: SWI-SNF_Ssr4; pfam08549 573370013098 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 573370013099 protein binding site [polypeptide binding]; other site 573370013100 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 573370013101 protein binding site [polypeptide binding]; other site 573370013102 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 573370013103 protein binding site [polypeptide binding]; other site 573370013104 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 573370013105 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 573370013106 protein binding site [polypeptide binding]; other site 573370013107 Uncharacterized conserved protein [Function unknown]; Region: COG1433 573370013108 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 573370013109 LemA family; Region: LemA; cl00742 573370013110 TPR repeat; Region: TPR_11; pfam13414 573370013111 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370013112 binding surface 573370013113 TPR motif; other site 573370013114 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370013115 binding surface 573370013116 Tetratricopeptide repeat; Region: TPR_16; pfam13432 573370013117 TPR motif; other site 573370013118 Tetratricopeptide repeat; Region: TPR_16; pfam13432 573370013119 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573370013120 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 573370013121 Transposase IS200 like; Region: Y1_Tnp; pfam01797 573370013122 Transposase domain (DUF772); Region: DUF772; pfam05598 573370013123 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573370013124 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 573370013125 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573370013126 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370013127 PAS domain; Region: PAS_9; pfam13426 573370013128 putative active site [active] 573370013129 heme pocket [chemical binding]; other site 573370013130 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 573370013131 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370013132 Walker A motif; other site 573370013133 ATP binding site [chemical binding]; other site 573370013134 Walker B motif; other site 573370013135 arginine finger; other site 573370013136 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 573370013137 AAA domain; Region: AAA_17; pfam13207 573370013138 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 573370013139 active site 573370013140 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 573370013141 EcsC protein family; Region: EcsC; pfam12787 573370013142 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370013143 PAS domain; Region: PAS; smart00091 573370013144 PAS fold; Region: PAS_4; pfam08448 573370013145 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 573370013146 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 573370013147 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 573370013148 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 573370013149 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 573370013150 EAL domain; Region: EAL; pfam00563 573370013151 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 573370013152 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 573370013153 Switch II region; other site 573370013154 G4 box; other site 573370013155 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 573370013156 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 573370013157 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 573370013158 Transposase; Region: DEDD_Tnp_IS110; pfam01548 573370013159 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 573370013160 Transposase; Region: DEDD_Tnp_IS110; pfam01548 573370013161 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 573370013162 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573370013163 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 573370013164 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 573370013165 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 573370013166 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573370013167 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 573370013168 Helix-turn-helix domain; Region: HTH_28; pfam13518 573370013169 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 573370013170 putative CheA interaction surface; other site 573370013171 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370013172 dimerization interface [polypeptide binding]; other site 573370013173 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370013174 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573370013175 dimer interface [polypeptide binding]; other site 573370013176 putative CheW interface [polypeptide binding]; other site 573370013177 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 573370013178 PAS domain S-box; Region: sensory_box; TIGR00229 573370013179 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370013180 putative active site [active] 573370013181 heme pocket [chemical binding]; other site 573370013182 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 573370013183 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370013184 putative active site [active] 573370013185 heme pocket [chemical binding]; other site 573370013186 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370013187 dimer interface [polypeptide binding]; other site 573370013188 phosphorylation site [posttranslational modification] 573370013189 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370013190 ATP binding site [chemical binding]; other site 573370013191 Mg2+ binding site [ion binding]; other site 573370013192 G-X-G motif; other site 573370013193 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370013194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370013195 active site 573370013196 phosphorylation site [posttranslational modification] 573370013197 intermolecular recognition site; other site 573370013198 dimerization interface [polypeptide binding]; other site 573370013199 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 573370013200 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370013201 metal binding site [ion binding]; metal-binding site 573370013202 active site 573370013203 I-site; other site 573370013204 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 573370013205 Domain of unknown function (DUF4317); Region: DUF4317; pfam14199 573370013206 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 573370013207 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 573370013208 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573370013209 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 573370013210 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 573370013211 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 573370013212 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573370013213 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 573370013214 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370013215 active site 573370013216 phosphorylation site [posttranslational modification] 573370013217 intermolecular recognition site; other site 573370013218 dimerization interface [polypeptide binding]; other site 573370013219 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370013220 active site 573370013221 phosphorylation site [posttranslational modification] 573370013222 intermolecular recognition site; other site 573370013223 dimerization interface [polypeptide binding]; other site 573370013224 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370013225 metal binding site [ion binding]; metal-binding site 573370013226 active site 573370013227 I-site; other site 573370013228 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370013229 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370013230 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370013231 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370013232 putative active site [active] 573370013233 heme pocket [chemical binding]; other site 573370013234 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370013235 putative active site [active] 573370013236 heme pocket [chemical binding]; other site 573370013237 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370013238 dimer interface [polypeptide binding]; other site 573370013239 phosphorylation site [posttranslational modification] 573370013240 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370013241 ATP binding site [chemical binding]; other site 573370013242 Mg2+ binding site [ion binding]; other site 573370013243 G-X-G motif; other site 573370013244 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 573370013245 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 573370013246 ligand binding site [chemical binding]; other site 573370013247 PAS domain; Region: PAS_9; pfam13426 573370013248 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370013249 putative active site [active] 573370013250 heme pocket [chemical binding]; other site 573370013251 PAS domain S-box; Region: sensory_box; TIGR00229 573370013252 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370013253 putative active site [active] 573370013254 heme pocket [chemical binding]; other site 573370013255 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370013256 dimer interface [polypeptide binding]; other site 573370013257 phosphorylation site [posttranslational modification] 573370013258 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370013259 ATP binding site [chemical binding]; other site 573370013260 Mg2+ binding site [ion binding]; other site 573370013261 G-X-G motif; other site 573370013262 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370013263 active site 573370013264 phosphorylation site [posttranslational modification] 573370013265 intermolecular recognition site; other site 573370013266 dimerization interface [polypeptide binding]; other site 573370013267 potential frameshift: common BLAST hit: gi|89901132|ref|YP_523603.1| MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor 573370013268 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 573370013269 TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926 573370013270 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 573370013271 PAS domain; Region: PAS_10; pfam13596 573370013272 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370013273 PAS domain; Region: PAS_9; pfam13426 573370013274 putative active site [active] 573370013275 heme pocket [chemical binding]; other site 573370013276 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 573370013277 CheB methylesterase; Region: CheB_methylest; pfam01339 573370013278 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 573370013279 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 573370013280 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 573370013281 Transposase, Mutator family; Region: Transposase_mut; cl19537 573370013282 Domain of unknown function (DUF932); Region: DUF932; cl12129 573370013283 Restriction endonuclease BglII; Region: Endonuc-BglII; pfam09195 573370013284 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 573370013285 Part of AAA domain; Region: AAA_19; pfam13245 573370013286 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 573370013287 Hemerythrin; Region: Hemerythrin; cd12107 573370013288 Fe binding site [ion binding]; other site 573370013289 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370013290 active site 573370013291 phosphorylation site [posttranslational modification] 573370013292 intermolecular recognition site; other site 573370013293 dimerization interface [polypeptide binding]; other site 573370013294 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 573370013295 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 573370013296 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 573370013297 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370013298 dimerization interface [polypeptide binding]; other site 573370013299 PAS domain S-box; Region: sensory_box; TIGR00229 573370013300 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370013301 putative active site [active] 573370013302 heme pocket [chemical binding]; other site 573370013303 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573370013304 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370013305 phosphorylation site [posttranslational modification] 573370013306 dimer interface [polypeptide binding]; other site 573370013307 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370013308 ATP binding site [chemical binding]; other site 573370013309 Mg2+ binding site [ion binding]; other site 573370013310 G-X-G motif; other site 573370013311 Sensory domain found in PocR; Region: PocR; pfam10114 573370013312 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370013313 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370013314 putative active site [active] 573370013315 heme pocket [chemical binding]; other site 573370013316 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370013317 putative active site [active] 573370013318 heme pocket [chemical binding]; other site 573370013319 GAF domain; Region: GAF_2; pfam13185 573370013320 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370013321 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370013322 putative active site [active] 573370013323 heme pocket [chemical binding]; other site 573370013324 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 573370013325 PAS domain; Region: PAS_8; pfam13188 573370013326 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370013327 putative active site [active] 573370013328 heme pocket [chemical binding]; other site 573370013329 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370013330 dimer interface [polypeptide binding]; other site 573370013331 phosphorylation site [posttranslational modification] 573370013332 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370013333 ATP binding site [chemical binding]; other site 573370013334 Mg2+ binding site [ion binding]; other site 573370013335 G-X-G motif; other site 573370013336 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370013337 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370013338 active site 573370013339 phosphorylation site [posttranslational modification] 573370013340 intermolecular recognition site; other site 573370013341 dimerization interface [polypeptide binding]; other site 573370013342 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 573370013343 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370013344 metal binding site [ion binding]; metal-binding site 573370013345 active site 573370013346 I-site; other site 573370013347 Staphylococcal nuclease homologues; Region: SNc; smart00318 573370013348 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 573370013349 Catalytic site; other site 573370013350 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 573370013351 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 573370013352 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 573370013353 metal ion-dependent adhesion site (MIDAS); other site 573370013354 CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09739 573370013355 CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737 573370013356 CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cd09736 573370013357 CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cl09829 573370013358 CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673 573370013359 CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562 573370013360 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-F; cd09718 573370013361 Domain of unknown function (DUF932); Region: DUF932; cl12129 573370013362 Restriction endonuclease BglII; Region: Endonuc-BglII; pfam09195 573370013363 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 573370013364 Part of AAA domain; Region: AAA_19; pfam13245 573370013365 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 573370013366 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 573370013367 SCP1.201-like deaminase; Region: SCP1201-deam; pfam14428 573370013368 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 573370013369 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 573370013370 dimer interface [polypeptide binding]; other site 573370013371 ssDNA binding site [nucleotide binding]; other site 573370013372 tetramer (dimer of dimers) interface [polypeptide binding]; other site 573370013373 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 573370013374 polymerase nucleotide-binding site; other site 573370013375 DNA-binding residues [nucleotide binding]; DNA binding site 573370013376 nucleotide binding site [chemical binding]; other site 573370013377 primase nucleotide-binding site [nucleotide binding]; other site 573370013378 Domain of unknown function (DUF927); Region: DUF927; cl12098 573370013379 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 573370013380 D5 N terminal like; Region: D5_N; pfam08706 573370013381 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 573370013382 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; cl19880 573370013383 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 573370013384 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 573370013385 Domain of unknown function (DUF927); Region: DUF927; cl12098 573370013386 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 573370013387 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 573370013388 active site 573370013389 catalytic residues [active] 573370013390 DNA binding site [nucleotide binding] 573370013391 Int/Topo IB signature motif; other site 573370013392 Protein of unknown function (DUF721); Region: DUF721; pfam05258 573370013393 S-adenosylmethionine synthetase; Validated; Region: PRK05250 573370013394 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 573370013395 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 573370013396 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 573370013397 Pantoate-beta-alanine ligase; Region: PanC; cd00560 573370013398 active site 573370013399 ATP-binding site [chemical binding]; other site 573370013400 pantoate-binding site; other site 573370013401 HXXH motif; other site 573370013402 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 573370013403 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 573370013404 dimerization interface 3.5A [polypeptide binding]; other site 573370013405 active site 573370013406 Uncharacterized conserved protein [Function unknown]; Region: COG3334 573370013407 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 573370013408 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 573370013409 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 573370013410 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 573370013411 ATP synthase I chain; Region: ATP_synt_I; pfam03899 573370013412 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 573370013413 ATP synthase subunit C; Region: ATP-synt_C; cl00466 573370013414 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 573370013415 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 573370013416 CoA binding domain; Region: CoA_binding; pfam02629 573370013417 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 573370013418 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 573370013419 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 573370013420 HAMP domain; Region: HAMP; pfam00672 573370013421 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 573370013422 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370013423 Walker A motif; other site 573370013424 ATP binding site [chemical binding]; other site 573370013425 Walker B motif; other site 573370013426 arginine finger; other site 573370013427 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 573370013428 Ligand Binding Site [chemical binding]; other site 573370013429 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 573370013430 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 573370013431 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 573370013432 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 573370013433 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 573370013434 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 573370013435 dimer interface [polypeptide binding]; other site 573370013436 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 573370013437 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573370013438 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573370013439 DNA binding residues [nucleotide binding] 573370013440 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 573370013441 dimer interface [polypeptide binding]; other site 573370013442 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 573370013443 putative active site; other site 573370013444 catalytic residue [active] 573370013445 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 573370013446 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 573370013447 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 573370013448 NlpC/P60 family; Region: NLPC_P60; pfam00877 573370013449 Bacterial virulence factor haemolysin; Region: SMP_2; cl11479 573370013450 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370013451 dimerization interface [polypeptide binding]; other site 573370013452 PAS fold; Region: PAS_7; pfam12860 573370013453 PAS fold; Region: PAS; pfam00989 573370013454 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370013455 putative active site [active] 573370013456 heme pocket [chemical binding]; other site 573370013457 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370013458 dimer interface [polypeptide binding]; other site 573370013459 phosphorylation site [posttranslational modification] 573370013460 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370013461 ATP binding site [chemical binding]; other site 573370013462 Mg2+ binding site [ion binding]; other site 573370013463 G-X-G motif; other site 573370013464 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370013465 active site 573370013466 phosphorylation site [posttranslational modification] 573370013467 intermolecular recognition site; other site 573370013468 dimerization interface [polypeptide binding]; other site 573370013469 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 573370013470 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 573370013471 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 573370013472 NAD(P) binding site [chemical binding]; other site 573370013473 FOG: CBS domain [General function prediction only]; Region: COG0517 573370013474 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 573370013475 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 573370013476 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 573370013477 anti sigma factor interaction site; other site 573370013478 regulatory phosphorylation site [posttranslational modification]; other site 573370013479 Occludin homology domain; Region: Occludin_ELL; pfam07303 573370013480 PAS domain S-box; Region: sensory_box; TIGR00229 573370013481 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370013482 putative active site [active] 573370013483 heme pocket [chemical binding]; other site 573370013484 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370013485 metal binding site [ion binding]; metal-binding site 573370013486 active site 573370013487 I-site; other site 573370013488 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 573370013489 anion transporter; Region: dass; TIGR00785 573370013490 transmembrane helices; other site 573370013491 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 573370013492 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 573370013493 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 573370013494 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 573370013495 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370013496 putative active site [active] 573370013497 heme pocket [chemical binding]; other site 573370013498 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370013499 dimer interface [polypeptide binding]; other site 573370013500 phosphorylation site [posttranslational modification] 573370013501 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370013502 ATP binding site [chemical binding]; other site 573370013503 Mg2+ binding site [ion binding]; other site 573370013504 G-X-G motif; other site 573370013505 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370013506 active site 573370013507 phosphorylation site [posttranslational modification] 573370013508 intermolecular recognition site; other site 573370013509 dimerization interface [polypeptide binding]; other site 573370013510 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 573370013511 heme-binding residues [chemical binding]; other site 573370013512 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 573370013513 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 573370013514 Cysteine-rich domain; Region: CCG; pfam02754 573370013515 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 573370013516 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 573370013517 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370013518 TPR motif; other site 573370013519 binding surface 573370013520 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 573370013521 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 573370013522 N-acetyl-D-glucosamine binding site [chemical binding]; other site 573370013523 catalytic residue [active] 573370013524 YcfA-like protein; Region: YcfA; pfam07927 573370013525 AIPR protein; Region: AIPR; pfam10592 573370013526 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 573370013527 MgtE intracellular N domain; Region: MgtE_N; smart00924 573370013528 FOG: CBS domain [General function prediction only]; Region: COG0517 573370013529 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 573370013530 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 573370013531 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 573370013532 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573370013533 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573370013534 putative substrate translocation pore; other site 573370013535 Transposase; Region: DEDD_Tnp_IS110; pfam01548 573370013536 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 573370013537 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 573370013538 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 573370013539 active site 573370013540 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 573370013541 Ubiquitin-like proteins; Region: UBQ; cl00155 573370013542 charged pocket; other site 573370013543 hydrophobic patch; other site 573370013544 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 573370013545 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 573370013546 ATP binding site [chemical binding]; other site 573370013547 substrate interface [chemical binding]; other site 573370013548 GAF domain; Region: GAF_3; pfam13492 573370013549 Protein of unknown function (DUF342); Region: DUF342; pfam03961 573370013550 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 573370013551 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 573370013552 active site 573370013553 Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; cl19163 573370013554 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 573370013555 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 573370013556 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 573370013557 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 573370013558 Ligand Binding Site [chemical binding]; other site 573370013559 Electron transfer flavoprotein domain; Region: ETF; pfam01012 573370013560 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 573370013561 Ligand Binding Site [chemical binding]; other site 573370013562 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 573370013563 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 573370013564 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 573370013565 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 573370013566 active site 573370013567 dimer interface [polypeptide binding]; other site 573370013568 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 573370013569 Ligand Binding Site [chemical binding]; other site 573370013570 Molecular Tunnel; other site 573370013571 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 573370013572 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573370013573 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370013574 S-adenosylmethionine binding site [chemical binding]; other site 573370013575 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 573370013576 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 573370013577 active site 573370013578 dimer interface [polypeptide binding]; other site 573370013579 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 573370013580 Ligand Binding Site [chemical binding]; other site 573370013581 Molecular Tunnel; other site 573370013582 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 573370013583 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 573370013584 Ligand binding site; other site 573370013585 Putative Catalytic site; other site 573370013586 DXD motif; other site 573370013587 macrolide transporter subunit MacA; Provisional; Region: PRK11578 573370013588 HlyD family secretion protein; Region: HlyD_3; pfam13437 573370013589 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 573370013590 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 573370013591 Outer membrane efflux protein; Region: OEP; pfam02321 573370013592 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 573370013593 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 573370013594 Walker A/P-loop; other site 573370013595 ATP binding site [chemical binding]; other site 573370013596 Q-loop/lid; other site 573370013597 ABC transporter signature motif; other site 573370013598 Walker B; other site 573370013599 D-loop; other site 573370013600 H-loop/switch region; other site 573370013601 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573370013602 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 573370013603 FtsX-like permease family; Region: FtsX; pfam02687 573370013604 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 573370013605 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 573370013606 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573370013607 catalytic residue [active] 573370013608 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 573370013609 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 573370013610 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370013611 metal binding site [ion binding]; metal-binding site 573370013612 active site 573370013613 I-site; other site 573370013614 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 573370013615 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 573370013616 Ligand binding site; other site 573370013617 Putative Catalytic site; other site 573370013618 DXD motif; other site 573370013619 Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935 573370013620 putative active site [active] 573370013621 putative catalytic site [active] 573370013622 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573370013623 Zn2+ binding site [ion binding]; other site 573370013624 Mg2+ binding site [ion binding]; other site 573370013625 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370013626 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370013627 active site 573370013628 phosphorylation site [posttranslational modification] 573370013629 intermolecular recognition site; other site 573370013630 dimerization interface [polypeptide binding]; other site 573370013631 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 573370013632 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370013633 Mg2+ binding site [ion binding]; other site 573370013634 G-X-G motif; other site 573370013635 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 573370013636 anti sigma factor interaction site; other site 573370013637 regulatory phosphorylation site [posttranslational modification]; other site 573370013638 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 573370013639 putative binding surface; other site 573370013640 active site 573370013641 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 573370013642 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 573370013643 putative binding surface; other site 573370013644 active site 573370013645 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 573370013646 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370013647 ATP binding site [chemical binding]; other site 573370013648 Mg2+ binding site [ion binding]; other site 573370013649 G-X-G motif; other site 573370013650 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 573370013651 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 573370013652 metal binding site 2 [ion binding]; metal-binding site 573370013653 putative DNA binding helix; other site 573370013654 metal binding site 1 [ion binding]; metal-binding site 573370013655 dimer interface [polypeptide binding]; other site 573370013656 structural Zn2+ binding site [ion binding]; other site 573370013657 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 573370013658 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 573370013659 Sulfate transporter family; Region: Sulfate_transp; pfam00916 573370013660 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 573370013661 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 573370013662 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573370013663 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573370013664 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 573370013665 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 573370013666 Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596 573370013667 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573370013668 von Willebrand factor type A domain; Region: VWA_2; pfam13519 573370013669 metal ion-dependent adhesion site (MIDAS); other site 573370013670 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 573370013671 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 573370013672 ligand binding site [chemical binding]; other site 573370013673 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 573370013674 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 573370013675 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 573370013676 Peptidase M16C associated; Region: M16C_assoc; pfam08367 573370013677 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 573370013678 Bacterial SH3 domain; Region: SH3_3; pfam08239 573370013679 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 573370013680 glycogen branching enzyme; Provisional; Region: PRK12313 573370013681 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 573370013682 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 573370013683 active site 573370013684 catalytic site [active] 573370013685 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 573370013686 4-alpha-glucanotransferase; Provisional; Region: PRK14508 573370013687 Putative lysophospholipase; Region: Hydrolase_4; cl19140 573370013688 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 573370013689 Fumarylacetoacetase N-terminal; Region: FAA_hydrolase_N; pfam09298 573370013690 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 573370013691 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 573370013692 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 573370013693 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 573370013694 tandem repeat interface [polypeptide binding]; other site 573370013695 oligomer interface [polypeptide binding]; other site 573370013696 active site residues [active] 573370013697 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 573370013698 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 573370013699 RNA binding site [nucleotide binding]; other site 573370013700 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 573370013701 RNA binding site [nucleotide binding]; other site 573370013702 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 573370013703 RNA binding site [nucleotide binding]; other site 573370013704 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 573370013705 RNA binding site [nucleotide binding]; other site 573370013706 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 573370013707 RNA binding site [nucleotide binding]; other site 573370013708 S1 RNA binding domain; Region: S1; pfam00575 573370013709 RNA binding site [nucleotide binding]; other site 573370013710 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 573370013711 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 573370013712 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573370013713 FeS/SAM binding site; other site 573370013714 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 573370013715 active site 573370013716 dimerization interface [polypeptide binding]; other site 573370013717 SnoaL-like domain; Region: SnoaL_4; pfam13577 573370013718 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 573370013719 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 573370013720 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 573370013721 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 573370013722 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 573370013723 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 573370013724 Ligand Binding Site [chemical binding]; other site 573370013725 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 573370013726 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 573370013727 active site 573370013728 NTP binding site [chemical binding]; other site 573370013729 metal binding triad [ion binding]; metal-binding site 573370013730 antibiotic binding site [chemical binding]; other site 573370013731 recombinase A; Provisional; Region: recA; PRK09354 573370013732 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 573370013733 hexamer interface [polypeptide binding]; other site 573370013734 Walker A motif; other site 573370013735 ATP binding site [chemical binding]; other site 573370013736 Walker B motif; other site 573370013737 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 573370013738 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 573370013739 motif 1; other site 573370013740 active site 573370013741 motif 2; other site 573370013742 motif 3; other site 573370013743 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 573370013744 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 573370013745 DHHA1 domain; Region: DHHA1; pfam02272 573370013746 Chloramphenicol acetyltransferase; Region: CAT; cl02008 573370013747 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 573370013748 HicB family; Region: HicB; pfam05534 573370013749 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 573370013750 active site 573370013751 dimer interface [polypeptide binding]; other site 573370013752 AMIN domain; Region: AMIN; pfam11741 573370013753 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 573370013754 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 573370013755 active site 573370013756 metal binding site [ion binding]; metal-binding site 573370013757 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 573370013758 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 573370013759 glutaminase active site [active] 573370013760 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 573370013761 dimer interface [polypeptide binding]; other site 573370013762 active site 573370013763 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 573370013764 dimer interface [polypeptide binding]; other site 573370013765 active site 573370013766 UreI/AmiS family, proton-gated urea channel and putative amide transporters; Region: UreI_AmiS_like; cl03519 573370013767 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 573370013768 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 573370013769 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 573370013770 G1 box; other site 573370013771 putative GEF interaction site [polypeptide binding]; other site 573370013772 GTP/Mg2+ binding site [chemical binding]; other site 573370013773 Switch I region; other site 573370013774 G2 box; other site 573370013775 G3 box; other site 573370013776 Switch II region; other site 573370013777 G4 box; other site 573370013778 G5 box; other site 573370013779 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 573370013780 Elongation Factor G, domain II; Region: EFG_II; pfam14492 573370013781 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 573370013782 putative ligand binding pocket/active site [active] 573370013783 putative metal binding site [ion binding]; other site 573370013784 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 573370013785 Iron-sulfur cluster-binding domain; Region: SPASM; pfam13186 573370013786 CHASE4 domain; Region: CHASE4; pfam05228 573370013787 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370013788 dimer interface [polypeptide binding]; other site 573370013789 phosphorylation site [posttranslational modification] 573370013790 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370013791 ATP binding site [chemical binding]; other site 573370013792 Mg2+ binding site [ion binding]; other site 573370013793 G-X-G motif; other site 573370013794 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370013795 active site 573370013796 phosphorylation site [posttranslational modification] 573370013797 intermolecular recognition site; other site 573370013798 dimerization interface [polypeptide binding]; other site 573370013799 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 573370013800 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370013801 active site 573370013802 phosphorylation site [posttranslational modification] 573370013803 intermolecular recognition site; other site 573370013804 dimerization interface [polypeptide binding]; other site 573370013805 PemK-like protein; Region: PemK; cl00995 573370013806 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573370013807 dimerization interface [polypeptide binding]; other site 573370013808 putative DNA binding site [nucleotide binding]; other site 573370013809 putative Zn2+ binding site [ion binding]; other site 573370013810 Methyltransferase domain; Region: Methyltransf_31; pfam13847 573370013811 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370013812 S-adenosylmethionine binding site [chemical binding]; other site 573370013813 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 573370013814 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 573370013815 homotetramer interface [polypeptide binding]; other site 573370013816 ligand binding site [chemical binding]; other site 573370013817 catalytic site [active] 573370013818 NAD binding site [chemical binding]; other site 573370013819 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370013820 metal binding site [ion binding]; metal-binding site 573370013821 active site 573370013822 I-site; other site 573370013823 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 573370013824 homodimer interaction site [polypeptide binding]; other site 573370013825 cofactor binding site; other site 573370013826 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573370013827 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573370013828 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 573370013829 Walker A/P-loop; other site 573370013830 ATP binding site [chemical binding]; other site 573370013831 Q-loop/lid; other site 573370013832 ABC transporter signature motif; other site 573370013833 Walker B; other site 573370013834 D-loop; other site 573370013835 H-loop/switch region; other site 573370013836 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 573370013837 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 573370013838 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 573370013839 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 573370013840 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 573370013841 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 573370013842 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; smart00902 573370013843 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 573370013844 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 573370013845 Transposase; Region: DEDD_Tnp_IS110; pfam01548 573370013846 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 573370013847 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 573370013848 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 573370013849 molybdopterin cofactor binding site; other site 573370013850 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 573370013851 molybdopterin cofactor binding site; other site 573370013852 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 573370013853 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 573370013854 HAMP domain; Region: HAMP; pfam00672 573370013855 PAS domain; Region: PAS_9; pfam13426 573370013856 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370013857 putative active site [active] 573370013858 heme pocket [chemical binding]; other site 573370013859 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370013860 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 573370013861 dimer interface [polypeptide binding]; other site 573370013862 putative CheW interface [polypeptide binding]; other site 573370013863 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573370013864 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573370013865 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 573370013866 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 573370013867 type IV secretion system T-DNA border endonuclease VirD2; Provisional; Region: PRK13863 573370013868 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 573370013869 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 573370013870 Tetramer interface [polypeptide binding]; other site 573370013871 active site 573370013872 FMN-binding site [chemical binding]; other site 573370013873 CGGC domain; Region: CGGC; cl02356 573370013874 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573370013875 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573370013876 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 573370013877 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 573370013878 DNA binding residues [nucleotide binding] 573370013879 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 573370013880 putative acyl-acceptor binding pocket; other site 573370013881 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 573370013882 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 573370013883 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 573370013884 active site 573370013885 metal binding site [ion binding]; metal-binding site 573370013886 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 573370013887 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 573370013888 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573370013889 dimerization interface [polypeptide binding]; other site 573370013890 putative DNA binding site [nucleotide binding]; other site 573370013891 putative Zn2+ binding site [ion binding]; other site 573370013892 AsnC family; Region: AsnC_trans_reg; pfam01037 573370013893 Proline dehydrogenase; Region: Pro_dh; pfam01619 573370013894 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 573370013895 Glutamate binding site [chemical binding]; other site 573370013896 homodimer interface [polypeptide binding]; other site 573370013897 NAD binding site [chemical binding]; other site 573370013898 catalytic residues [active] 573370013899 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 573370013900 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573370013901 non-specific DNA binding site [nucleotide binding]; other site 573370013902 salt bridge; other site 573370013903 sequence-specific DNA binding site [nucleotide binding]; other site 573370013904 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 573370013905 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 573370013906 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 573370013907 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 573370013908 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 573370013909 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 573370013910 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 573370013911 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 573370013912 EamA-like transporter family; Region: EamA; pfam00892 573370013913 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 573370013914 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 573370013915 ATP binding site [chemical binding]; other site 573370013916 Mg++ binding site [ion binding]; other site 573370013917 motif III; other site 573370013918 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573370013919 nucleotide binding region [chemical binding]; other site 573370013920 ATP-binding site [chemical binding]; other site 573370013921 African swine fever virus J13L protein; Region: ASFV_J13L; pfam05568 573370013922 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370013923 metal binding site [ion binding]; metal-binding site 573370013924 active site 573370013925 I-site; other site 573370013926 nodulation ABC transporter NodI; Provisional; Region: PRK13537 573370013927 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573370013928 Walker A/P-loop; other site 573370013929 ATP binding site [chemical binding]; other site 573370013930 Q-loop/lid; other site 573370013931 ABC transporter signature motif; other site 573370013932 Walker B; other site 573370013933 D-loop; other site 573370013934 H-loop/switch region; other site 573370013935 ABC-2 type transporter; Region: ABC2_membrane; cl17235 573370013936 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 573370013937 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573370013938 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573370013939 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 573370013940 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370013941 active site 573370013942 phosphorylation site [posttranslational modification] 573370013943 intermolecular recognition site; other site 573370013944 dimerization interface [polypeptide binding]; other site 573370013945 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573370013946 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573370013947 non-specific DNA binding site [nucleotide binding]; other site 573370013948 salt bridge; other site 573370013949 sequence-specific DNA binding site [nucleotide binding]; other site 573370013950 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370013951 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370013952 putative active site [active] 573370013953 heme pocket [chemical binding]; other site 573370013954 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370013955 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 573370013956 putative active site [active] 573370013957 heme pocket [chemical binding]; other site 573370013958 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 573370013959 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370013960 dimer interface [polypeptide binding]; other site 573370013961 phosphorylation site [posttranslational modification] 573370013962 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370013963 ATP binding site [chemical binding]; other site 573370013964 Mg2+ binding site [ion binding]; other site 573370013965 G-X-G motif; other site 573370013966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370013967 active site 573370013968 phosphorylation site [posttranslational modification] 573370013969 intermolecular recognition site; other site 573370013970 dimerization interface [polypeptide binding]; other site 573370013971 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 573370013972 putative binding surface; other site 573370013973 active site 573370013974 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 573370013975 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 573370013976 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 573370013977 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 573370013978 Transcriptional regulator PadR-like family; Region: PadR; cl17335 573370013979 AAK_UMPK-MosAB: This CD includes the alpha and beta subunits of the Mo storage protein (MosA and MosB) which are related to uridine monophosphate kinase (UMPK) enzymes that catalyze the phosphorylation of UMP by ATP, yielding UDP, and playing a key role...; Region: AAK_UMPK-MosAB; cd04255 573370013980 putative nucleotide binding site [chemical binding]; other site 573370013981 putative substrate binding site [chemical binding]; other site 573370013982 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 573370013983 4Fe-4S binding domain; Region: Fer4_5; pfam12801 573370013984 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 573370013985 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 573370013986 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370013987 active site 573370013988 phosphorylation site [posttranslational modification] 573370013989 intermolecular recognition site; other site 573370013990 dimerization interface [polypeptide binding]; other site 573370013991 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 573370013992 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 573370013993 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 573370013994 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 573370013995 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573370013996 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 573370013997 FtsX-like permease family; Region: FtsX; pfam02687 573370013998 Fic family protein [Function unknown]; Region: COG3177 573370013999 Fic/DOC family; Region: Fic; pfam02661 573370014000 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 573370014001 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573370014002 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573370014003 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573370014004 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573370014005 B12 binding domain; Region: B12-binding; pfam02310 573370014006 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573370014007 Radical SAM superfamily; Region: Radical_SAM; pfam04055 573370014008 FeS/SAM binding site; other site 573370014009 short chain dehydrogenase; Provisional; Region: PRK07024 573370014010 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573370014011 NAD(P) binding site [chemical binding]; other site 573370014012 active site 573370014013 UbiA family of prenyltransferases (PTases), Unknown subgroup; Region: PT_UbiA_2; cd13963 573370014014 putative active site [active] 573370014015 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 573370014016 active site 573370014017 substrate binding site [chemical binding]; other site 573370014018 cosubstrate binding site; other site 573370014019 catalytic site [active] 573370014020 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 573370014021 active site 573370014022 SAM binding site [chemical binding]; other site 573370014023 homodimer interface [polypeptide binding]; other site 573370014024 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 573370014025 active site 573370014026 AsmA family; Region: AsmA; pfam05170 573370014027 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 573370014028 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 573370014029 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 573370014030 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 573370014031 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573370014032 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 573370014033 active site 573370014034 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 573370014035 Peptidase family M23; Region: Peptidase_M23; pfam01551 573370014036 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 573370014037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370014038 active site 573370014039 phosphorylation site [posttranslational modification] 573370014040 intermolecular recognition site; other site 573370014041 dimerization interface [polypeptide binding]; other site 573370014042 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573370014043 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573370014044 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 573370014045 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573370014046 Walker A/P-loop; other site 573370014047 ATP binding site [chemical binding]; other site 573370014048 Q-loop/lid; other site 573370014049 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573370014050 ABC transporter signature motif; other site 573370014051 Walker B; other site 573370014052 D-loop; other site 573370014053 H-loop/switch region; other site 573370014054 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 573370014055 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 573370014056 ligand binding site [chemical binding]; other site 573370014057 flexible hinge region; other site 573370014058 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370014059 gamma-glutamyl kinase; Provisional; Region: PRK05429 573370014060 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 573370014061 nucleotide binding site [chemical binding]; other site 573370014062 homotetrameric interface [polypeptide binding]; other site 573370014063 putative phosphate binding site [ion binding]; other site 573370014064 putative allosteric binding site; other site 573370014065 PUA domain; Region: PUA; pfam01472 573370014066 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 573370014067 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573370014068 Zn2+ binding site [ion binding]; other site 573370014069 Mg2+ binding site [ion binding]; other site 573370014070 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 573370014071 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 573370014072 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 573370014073 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 573370014074 UPF0126 domain; Region: UPF0126; pfam03458 573370014075 Predicted membrane protein [Function unknown]; Region: COG2860 573370014076 UPF0126 domain; Region: UPF0126; pfam03458 573370014077 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 573370014078 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 573370014079 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573370014080 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 573370014081 Dihaem cytochrome c; Region: DHC; pfam09626 573370014082 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 573370014083 ATP cone domain; Region: ATP-cone; pfam03477 573370014084 Class III ribonucleotide reductase; Region: RNR_III; cd01675 573370014085 effector binding site; other site 573370014086 active site 573370014087 Zn binding site [ion binding]; other site 573370014088 glycine loop; other site 573370014089 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 573370014090 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573370014091 FeS/SAM binding site; other site 573370014092 hypothetical protein; Provisional; Region: PRK09256 573370014093 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 573370014094 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 573370014095 Ligand Binding Site [chemical binding]; other site 573370014096 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 573370014097 Ligand Binding Site [chemical binding]; other site 573370014098 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370014099 dimerization interface [polypeptide binding]; other site 573370014100 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370014101 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 573370014102 dimer interface [polypeptide binding]; other site 573370014103 putative CheW interface [polypeptide binding]; other site 573370014104 thioredoxin 2; Provisional; Region: PRK10996 573370014105 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 573370014106 catalytic residues [active] 573370014107 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 573370014108 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 573370014109 putative DNA binding site [nucleotide binding]; other site 573370014110 putative Zn2+ binding site [ion binding]; other site 573370014111 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370014112 metal binding site [ion binding]; metal-binding site 573370014113 active site 573370014114 I-site; other site 573370014115 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 573370014116 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370014117 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 573370014118 dimer interface [polypeptide binding]; other site 573370014119 putative CheW interface [polypeptide binding]; other site 573370014120 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 573370014121 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 573370014122 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 573370014123 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370014124 putative active site [active] 573370014125 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370014126 putative active site [active] 573370014127 heme pocket [chemical binding]; other site 573370014128 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370014129 putative active site [active] 573370014130 heme pocket [chemical binding]; other site 573370014131 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370014132 metal binding site [ion binding]; metal-binding site 573370014133 active site 573370014134 I-site; other site 573370014135 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 573370014136 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 573370014137 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 573370014138 active site 573370014139 HIGH motif; other site 573370014140 KMSKS motif; other site 573370014141 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 573370014142 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 573370014143 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 573370014144 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573370014145 substrate binding pocket [chemical binding]; other site 573370014146 membrane-bound complex binding site; other site 573370014147 hinge residues; other site 573370014148 PAS domain; Region: PAS; smart00091 573370014149 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 573370014150 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370014151 putative active site [active] 573370014152 heme pocket [chemical binding]; other site 573370014153 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370014154 dimer interface [polypeptide binding]; other site 573370014155 phosphorylation site [posttranslational modification] 573370014156 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370014157 ATP binding site [chemical binding]; other site 573370014158 Mg2+ binding site [ion binding]; other site 573370014159 G-X-G motif; other site 573370014160 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370014161 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370014162 active site 573370014163 phosphorylation site [posttranslational modification] 573370014164 intermolecular recognition site; other site 573370014165 dimerization interface [polypeptide binding]; other site 573370014166 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 573370014167 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 573370014168 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370014169 PAS domain; Region: PAS_9; pfam13426 573370014170 putative active site [active] 573370014171 heme pocket [chemical binding]; other site 573370014172 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 573370014173 Histidine kinase; Region: HisKA_2; pfam07568 573370014174 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370014175 ATP binding site [chemical binding]; other site 573370014176 Mg2+ binding site [ion binding]; other site 573370014177 G-X-G motif; other site 573370014178 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 573370014179 Ligand binding site; other site 573370014180 metal-binding site 573370014181 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573370014182 Zn2+ binding site [ion binding]; other site 573370014183 Mg2+ binding site [ion binding]; other site 573370014184 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 573370014185 catalytic core [active] 573370014186 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 573370014187 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 573370014188 HlyD family secretion protein; Region: HlyD_3; pfam13437 573370014189 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 573370014190 MMPL family; Region: MMPL; cl14618 573370014191 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 573370014192 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 573370014193 active site 573370014194 dimer interface [polypeptide binding]; other site 573370014195 effector binding site; other site 573370014196 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 573370014197 protein-splicing catalytic site; other site 573370014198 thioester formation/cholesterol transfer; other site 573370014199 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 573370014200 LAGLIDADG-like domain; Region: LAGLIDADG_3; pfam14528 573370014201 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 573370014202 TSCPD domain; Region: TSCPD; pfam12637 573370014203 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 573370014204 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 573370014205 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370014206 Walker A motif; other site 573370014207 ATP binding site [chemical binding]; other site 573370014208 Walker B motif; other site 573370014209 arginine finger; other site 573370014210 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 573370014211 Acylphosphatase; Region: Acylphosphatase; pfam00708 573370014212 hypothetical protein; Reviewed; Region: PRK00024 573370014213 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 573370014214 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 573370014215 MPN+ (JAMM) motif; other site 573370014216 Zinc-binding site [ion binding]; other site 573370014217 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 573370014218 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 573370014219 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 573370014220 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 573370014221 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573370014222 FeS/SAM binding site; other site 573370014223 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 573370014224 ATP cone domain; Region: ATP-cone; pfam03477 573370014225 Class III ribonucleotide reductase; Region: RNR_III; cd01675 573370014226 effector binding site; other site 573370014227 active site 573370014228 Zn binding site [ion binding]; other site 573370014229 glycine loop; other site 573370014230 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 573370014231 active site 573370014232 NTP binding site [chemical binding]; other site 573370014233 metal binding triad [ion binding]; metal-binding site 573370014234 antibiotic binding site [chemical binding]; other site 573370014235 HEPN domain; Region: HEPN; pfam05168 573370014236 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 573370014237 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 573370014238 HflX GTPase family; Region: HflX; cd01878 573370014239 G1 box; other site 573370014240 GTP/Mg2+ binding site [chemical binding]; other site 573370014241 Switch I region; other site 573370014242 G2 box; other site 573370014243 G3 box; other site 573370014244 Switch II region; other site 573370014245 G4 box; other site 573370014246 G5 box; other site 573370014247 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 573370014248 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 573370014249 Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_paraslipin; cd08829 573370014250 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 573370014251 Serine hydrolase (FSH1); Region: FSH1; pfam03959 573370014252 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 573370014253 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573370014254 dimer interface [polypeptide binding]; other site 573370014255 conserved gate region; other site 573370014256 putative PBP binding loops; other site 573370014257 ABC-ATPase subunit interface; other site 573370014258 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 573370014259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573370014260 dimer interface [polypeptide binding]; other site 573370014261 conserved gate region; other site 573370014262 putative PBP binding loops; other site 573370014263 ABC-ATPase subunit interface; other site 573370014264 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573370014265 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 573370014266 substrate binding pocket [chemical binding]; other site 573370014267 membrane-bound complex binding site; other site 573370014268 hinge residues; other site 573370014269 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 573370014270 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 573370014271 Walker A/P-loop; other site 573370014272 ATP binding site [chemical binding]; other site 573370014273 Q-loop/lid; other site 573370014274 ABC transporter signature motif; other site 573370014275 Walker B; other site 573370014276 D-loop; other site 573370014277 H-loop/switch region; other site 573370014278 Sulfite exporter TauE/SafE; Region: TauE; cl19196 573370014279 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 573370014280 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 573370014281 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 573370014282 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 573370014283 HSP70 interaction site [polypeptide binding]; other site 573370014284 Transposase domain (DUF772); Region: DUF772; pfam05598 573370014285 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573370014286 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 573370014287 Lysozyme family protein [General function prediction only]; Region: COG5526 573370014288 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl19279 573370014289 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 573370014290 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 573370014291 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 573370014292 Walker A/P-loop; other site 573370014293 ATP binding site [chemical binding]; other site 573370014294 Q-loop/lid; other site 573370014295 ABC transporter signature motif; other site 573370014296 Walker B; other site 573370014297 D-loop; other site 573370014298 H-loop/switch region; other site 573370014299 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 573370014300 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 573370014301 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 573370014302 Walker A/P-loop; other site 573370014303 ATP binding site [chemical binding]; other site 573370014304 Q-loop/lid; other site 573370014305 ABC transporter signature motif; other site 573370014306 Walker B; other site 573370014307 D-loop; other site 573370014308 H-loop/switch region; other site 573370014309 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 573370014310 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; cl19880 573370014311 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370014312 active site 573370014313 phosphorylation site [posttranslational modification] 573370014314 intermolecular recognition site; other site 573370014315 dimerization interface [polypeptide binding]; other site 573370014316 Class I aldolases; Region: Aldolase_Class_I; cl17187 573370014317 catalytic residue [active] 573370014318 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 573370014319 tetramer (dimer of dimers) interface [polypeptide binding]; other site 573370014320 active site 573370014321 dimer interface [polypeptide binding]; other site 573370014322 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 573370014323 purine monophosphate binding site [chemical binding]; other site 573370014324 dimer interface [polypeptide binding]; other site 573370014325 putative catalytic residues [active] 573370014326 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370014327 binding surface 573370014328 TPR repeat; Region: TPR_11; pfam13414 573370014329 TPR motif; other site 573370014330 TPR repeat; Region: TPR_11; pfam13414 573370014331 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370014332 binding surface 573370014333 TPR motif; other site 573370014334 Tetratricopeptide repeat; Region: TPR_19; pfam14559 573370014335 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12621 573370014336 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 573370014337 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 573370014338 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 573370014339 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 573370014340 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 573370014341 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 573370014342 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 573370014343 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 573370014344 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 573370014345 FliG N-terminal domain; Region: FliG_N; pfam14842 573370014346 FliG middle domain; Region: FliG_M; pfam14841 573370014347 FliG C-terminal domain; Region: FliG_C; pfam01706 573370014348 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 573370014349 Flagellar assembly protein FliH; Region: FliH; cl19405 573370014350 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 573370014351 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 573370014352 Walker A motif/ATP binding site; other site 573370014353 Walker B motif; other site 573370014354 aspartate aminotransferase; Provisional; Region: PRK05764 573370014355 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573370014356 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573370014357 homodimer interface [polypeptide binding]; other site 573370014358 catalytic residue [active] 573370014359 PAS domain S-box; Region: sensory_box; TIGR00229 573370014360 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370014361 putative active site [active] 573370014362 heme pocket [chemical binding]; other site 573370014363 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370014364 dimer interface [polypeptide binding]; other site 573370014365 phosphorylation site [posttranslational modification] 573370014366 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370014367 ATP binding site [chemical binding]; other site 573370014368 Mg2+ binding site [ion binding]; other site 573370014369 G-X-G motif; other site 573370014370 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370014371 active site 573370014372 phosphorylation site [posttranslational modification] 573370014373 intermolecular recognition site; other site 573370014374 dimerization interface [polypeptide binding]; other site 573370014375 Terminase small subunit; Region: Terminase_2; pfam03592 573370014376 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 573370014377 Terminase-like family; Region: Terminase_6; pfam03237 573370014378 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 573370014379 dimer interface [polypeptide binding]; other site 573370014380 Short C-terminal domain; Region: SHOCT; pfam09851 573370014381 TPR repeat; Region: TPR_11; pfam13414 573370014382 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573370014383 binding surface 573370014384 TPR motif; other site 573370014385 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 573370014386 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 573370014387 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370014388 S-adenosylmethionine binding site [chemical binding]; other site 573370014389 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 573370014390 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 573370014391 Ligand binding site; other site 573370014392 Putative Catalytic site; other site 573370014393 DXD motif; other site 573370014394 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370014395 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573370014396 putative active site [active] 573370014397 heme pocket [chemical binding]; other site 573370014398 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370014399 putative active site [active] 573370014400 heme pocket [chemical binding]; other site 573370014401 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573370014402 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370014403 dimer interface [polypeptide binding]; other site 573370014404 phosphorylation site [posttranslational modification] 573370014405 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370014406 ATP binding site [chemical binding]; other site 573370014407 Mg2+ binding site [ion binding]; other site 573370014408 G-X-G motif; other site 573370014409 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 573370014410 G1 box; other site 573370014411 GTP/Mg2+ binding site [chemical binding]; other site 573370014412 G2 box; other site 573370014413 Switch I region; other site 573370014414 G3 box; other site 573370014415 Switch II region; other site 573370014416 G4 box; other site 573370014417 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 573370014418 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370014419 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370014420 active site 573370014421 phosphorylation site [posttranslational modification] 573370014422 intermolecular recognition site; other site 573370014423 dimerization interface [polypeptide binding]; other site 573370014424 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 573370014425 putative binding surface; other site 573370014426 active site 573370014427 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573370014428 dimerization interface [polypeptide binding]; other site 573370014429 putative DNA binding site [nucleotide binding]; other site 573370014430 putative Zn2+ binding site [ion binding]; other site 573370014431 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 573370014432 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 573370014433 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370014434 putative active site [active] 573370014435 heme pocket [chemical binding]; other site 573370014436 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370014437 dimer interface [polypeptide binding]; other site 573370014438 phosphorylation site [posttranslational modification] 573370014439 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370014440 ATP binding site [chemical binding]; other site 573370014441 Mg2+ binding site [ion binding]; other site 573370014442 G-X-G motif; other site 573370014443 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370014444 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370014445 active site 573370014446 phosphorylation site [posttranslational modification] 573370014447 intermolecular recognition site; other site 573370014448 dimerization interface [polypeptide binding]; other site 573370014449 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 573370014450 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 573370014451 conserved cys residue [active] 573370014452 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573370014453 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573370014454 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 573370014455 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 573370014456 conserved cys residue [active] 573370014457 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 573370014458 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370014459 active site 573370014460 phosphorylation site [posttranslational modification] 573370014461 intermolecular recognition site; other site 573370014462 dimerization interface [polypeptide binding]; other site 573370014463 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370014464 Walker A motif; other site 573370014465 ATP binding site [chemical binding]; other site 573370014466 Walker B motif; other site 573370014467 arginine finger; other site 573370014468 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 573370014469 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 573370014470 elongation factor G; Reviewed; Region: PRK12740 573370014471 G1 box; other site 573370014472 putative GEF interaction site [polypeptide binding]; other site 573370014473 GTP/Mg2+ binding site [chemical binding]; other site 573370014474 Switch I region; other site 573370014475 G2 box; other site 573370014476 G3 box; other site 573370014477 Switch II region; other site 573370014478 G4 box; other site 573370014479 G5 box; other site 573370014480 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 573370014481 Elongation Factor G, domain II; Region: EFG_II; pfam14492 573370014482 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 573370014483 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 573370014484 ParB-like nuclease domain; Region: ParB; smart00470 573370014485 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 573370014486 Domain of unknown function (DUF3859); Region: DUF3859; pfam12975 573370014487 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573370014488 non-specific DNA binding site [nucleotide binding]; other site 573370014489 salt bridge; other site 573370014490 sequence-specific DNA binding site [nucleotide binding]; other site 573370014491 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 573370014492 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573370014493 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573370014494 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 573370014495 dimerization interface [polypeptide binding]; other site 573370014496 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 573370014497 substrate binding site [chemical binding]; other site 573370014498 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 573370014499 intersubunit interface [polypeptide binding]; other site 573370014500 active site 573370014501 zinc binding site [ion binding]; other site 573370014502 Na+ binding site [ion binding]; other site 573370014503 EamA-like transporter family; Region: EamA; pfam00892 573370014504 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 573370014505 EamA-like transporter family; Region: EamA; pfam00892 573370014506 FlaG protein; Region: FlaG; cl00591 573370014507 PAS domain S-box; Region: sensory_box; TIGR00229 573370014508 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573370014509 putative active site [active] 573370014510 heme pocket [chemical binding]; other site 573370014511 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 573370014512 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370014513 dimer interface [polypeptide binding]; other site 573370014514 phosphorylation site [posttranslational modification] 573370014515 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370014516 ATP binding site [chemical binding]; other site 573370014517 Mg2+ binding site [ion binding]; other site 573370014518 G-X-G motif; other site 573370014519 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 573370014520 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 573370014521 Walker A/P-loop; other site 573370014522 ATP binding site [chemical binding]; other site 573370014523 Q-loop/lid; other site 573370014524 ABC transporter signature motif; other site 573370014525 Walker B; other site 573370014526 D-loop; other site 573370014527 H-loop/switch region; other site 573370014528 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 573370014529 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 573370014530 TM-ABC transporter signature motif; other site 573370014531 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 573370014532 TM-ABC transporter signature motif; other site 573370014533 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 573370014534 dimerization interface [polypeptide binding]; other site 573370014535 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 573370014536 ligand binding site [chemical binding]; other site 573370014537 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 573370014538 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 573370014539 Walker A/P-loop; other site 573370014540 ATP binding site [chemical binding]; other site 573370014541 Q-loop/lid; other site 573370014542 ABC transporter signature motif; other site 573370014543 Walker B; other site 573370014544 D-loop; other site 573370014545 H-loop/switch region; other site 573370014546 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 573370014547 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 573370014548 inhibitor-cofactor binding pocket; inhibition site 573370014549 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573370014550 catalytic residue [active] 573370014551 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 573370014552 trimer interface [polypeptide binding]; other site 573370014553 active site 573370014554 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 573370014555 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 573370014556 hexamer interface [polypeptide binding]; other site 573370014557 ligand binding site [chemical binding]; other site 573370014558 putative active site [active] 573370014559 NAD(P) binding site [chemical binding]; other site 573370014560 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 573370014561 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 573370014562 PAS domain; Region: PAS; smart00091 573370014563 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370014564 Walker A motif; other site 573370014565 ATP binding site [chemical binding]; other site 573370014566 Walker B motif; other site 573370014567 arginine finger; other site 573370014568 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 573370014569 putative homodimer interface [polypeptide binding]; other site 573370014570 putative active site pocket [active] 573370014571 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 573370014572 Methyltransferase domain; Region: Methyltransf_31; pfam13847 573370014573 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573370014574 S-adenosylmethionine binding site [chemical binding]; other site 573370014575 Predicted transcriptional regulator [Transcription]; Region: COG3905 573370014576 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 573370014577 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 573370014578 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 573370014579 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 573370014580 active site 573370014581 Zn binding site [ion binding]; other site 573370014582 CHASE domain; Region: CHASE; pfam03924 573370014583 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 573370014584 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370014585 dimer interface [polypeptide binding]; other site 573370014586 phosphorylation site [posttranslational modification] 573370014587 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370014588 ATP binding site [chemical binding]; other site 573370014589 Mg2+ binding site [ion binding]; other site 573370014590 G-X-G motif; other site 573370014591 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370014592 active site 573370014593 phosphorylation site [posttranslational modification] 573370014594 intermolecular recognition site; other site 573370014595 dimerization interface [polypeptide binding]; other site 573370014596 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 573370014597 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 573370014598 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573370014599 Zn2+ binding site [ion binding]; other site 573370014600 Mg2+ binding site [ion binding]; other site 573370014601 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573370014602 Zn2+ binding site [ion binding]; other site 573370014603 Mg2+ binding site [ion binding]; other site 573370014604 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 573370014605 FOG: CBS domain [General function prediction only]; Region: COG0517 573370014606 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 573370014607 FOG: CBS domain [General function prediction only]; Region: COG0517 573370014608 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611 573370014609 Peptidase C13 family; Region: Peptidase_C13; cl02159 573370014610 AAA domain; Region: AAA_32; pfam13654 573370014611 lon-related putative ATP-dependent protease; Region: lon_rel; TIGR00764 573370014612 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 573370014613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573370014614 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573370014615 putative substrate translocation pore; other site 573370014616 Uncharacterized protein containing a ferredoxin domain (DUF2148); Region: DUF2148; cl19624 573370014617 Chromate resistance exported protein; Region: Chrome_Resist; cl01744 573370014618 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 573370014619 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 573370014620 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 573370014621 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 573370014622 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573370014623 dimerization interface [polypeptide binding]; other site 573370014624 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370014625 dimer interface [polypeptide binding]; other site 573370014626 phosphorylation site [posttranslational modification] 573370014627 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370014628 ATP binding site [chemical binding]; other site 573370014629 Mg2+ binding site [ion binding]; other site 573370014630 G-X-G motif; other site 573370014631 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573370014632 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370014633 active site 573370014634 phosphorylation site [posttranslational modification] 573370014635 intermolecular recognition site; other site 573370014636 dimerization interface [polypeptide binding]; other site 573370014637 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573370014638 DNA binding site [nucleotide binding] 573370014639 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 573370014640 aspartate aminotransferase; Provisional; Region: PRK05764 573370014641 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573370014642 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573370014643 homodimer interface [polypeptide binding]; other site 573370014644 catalytic residue [active] 573370014645 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 573370014646 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573370014647 dimer interface [polypeptide binding]; other site 573370014648 phosphorylation site [posttranslational modification] 573370014649 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573370014650 ATP binding site [chemical binding]; other site 573370014651 Mg2+ binding site [ion binding]; other site 573370014652 G-X-G motif; other site 573370014653 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 573370014654 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573370014655 active site 573370014656 phosphorylation site [posttranslational modification] 573370014657 intermolecular recognition site; other site 573370014658 dimerization interface [polypeptide binding]; other site 573370014659 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573370014660 Walker A motif; other site 573370014661 ATP binding site [chemical binding]; other site 573370014662 Walker B motif; other site 573370014663 arginine finger; other site 573370014664 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 573370014665 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573370014666 metal binding site [ion binding]; metal-binding site 573370014667 active site 573370014668 I-site; other site 573370014669 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 573370014670 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573370014671 ATP binding site [chemical binding]; other site 573370014672 putative Mg++ binding site [ion binding]; other site 573370014673 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573370014674 nucleotide binding region [chemical binding]; other site 573370014675 ATP-binding site [chemical binding]; other site 573370014676 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 573370014677 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 573370014678 active site 573370014679 substrate binding site [chemical binding]; other site 573370014680 catalytic site [active] 573370014681 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 573370014682 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 573370014683 Walker A/P-loop; other site 573370014684 ATP binding site [chemical binding]; other site 573370014685 Q-loop/lid; other site 573370014686 ABC transporter signature motif; other site 573370014687 Walker B; other site 573370014688 D-loop; other site 573370014689 H-loop/switch region; other site 573370014690 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 573370014691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 573370014692 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 573370014693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573370014694 dimer interface [polypeptide binding]; other site 573370014695 ABC-ATPase subunit interface; other site 573370014696 putative PBP binding loops; other site 573370014697 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 573370014698 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 573370014699 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 573370014700 active site 573370014701 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 573370014702 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 573370014703 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 573370014704 phosphate binding site [ion binding]; other site 573370014705 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 573370014706 domain_subunit interface; other site 573370014707 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 573370014708 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 573370014709 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 573370014710 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 573370014711 Restriction endonuclease; Region: Mrr_cat; pfam04471 573370014712 potential frameshift: common BLAST hit: gi|73668872|ref|YP_304887.1| transposase 573370014713 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573370014714 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 573370014715 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 573370014716 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 573370014717 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573370014718 Coenzyme A binding pocket [chemical binding]; other site 573370014719 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 573370014720 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 573370014721 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573370014722 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573370014723 dimer interface [polypeptide binding]; other site 573370014724 putative CheW interface [polypeptide binding]; other site 573370014725 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 573370014726 putative acyl-acceptor binding pocket; other site 573370014727 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 573370014728 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 573370014729 Active Sites [active] 573370014730 DNA topoisomerase I; Validated; Region: PRK06599 573370014731 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 573370014732 active site 573370014733 interdomain interaction site; other site 573370014734 putative metal-binding site [ion binding]; other site 573370014735 nucleotide binding site [chemical binding]; other site 573370014736 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 573370014737 domain I; other site 573370014738 DNA binding groove [nucleotide binding] 573370014739 phosphate binding site [ion binding]; other site 573370014740 domain II; other site 573370014741 domain III; other site 573370014742 nucleotide binding site [chemical binding]; other site 573370014743 catalytic site [active] 573370014744 domain IV; other site 573370014745 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 573370014746 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 573370014747 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 573370014748 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 573370014749 GTPase Era; Reviewed; Region: era; PRK00089 573370014750 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 573370014751 G1 box; other site 573370014752 GTP/Mg2+ binding site [chemical binding]; other site 573370014753 Switch I region; other site 573370014754 G2 box; other site 573370014755 Switch II region; other site 573370014756 G3 box; other site 573370014757 G4 box; other site 573370014758 G5 box; other site 573370014759 KH domain; Region: KH_2; pfam07650 573370014760 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 573370014761 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 573370014762 catalytic residue [active] 573370014763 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 573370014764 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 573370014765 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 573370014766 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 573370014767 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 573370014768 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 573370014769 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 573370014770 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 573370014771 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 573370014772 SnoaL-like domain; Region: SnoaL_3; pfam13474 573370014773 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 573370014774 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573370014775 active site 573370014776 adenylosuccinate lyase; Provisional; Region: PRK07492 573370014777 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 573370014778 tetramer interface [polypeptide binding]; other site 573370014779 active site 573370014780 Adenylosuccinate lyase C-terminus; Region: ADSL_C; pfam10397 573370014781 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 573370014782 Domain of unknown function DUF39; Region: DUF39; pfam01837 573370014783 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 573370014784 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 573370014785 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573370014786 P-loop; other site 573370014787 Magnesium ion binding site [ion binding]; other site 573370014788 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573370014789 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 573370014790 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 573370014791 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 573370014792 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573370014793 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 573370014794 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573370014795 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 573370014796 Transposase domain (DUF772); Region: DUF772; pfam05598 573370014797 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573370014798 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 573370014799 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 573370014800 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 573370014801 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 573370014802 Transposase, Mutator family; Region: Transposase_mut; cl19537 573370014803 B12 binding domain; Region: B12-binding; pfam02310 573370014804 B12 binding site [chemical binding]; other site 573370014805 Radical SAM superfamily; Region: Radical_SAM; pfam04055 573370014806 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573370014807 FeS/SAM binding site; other site 573370014808 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 573370014809 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 573370014810 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573370014811 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 573370014812 Atrophin-1 family; Region: Atrophin-1; pfam03154 573370014813 Helix-turn-helix domain; Region: HTH_28; pfam13518 573370014814 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 573370014815 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573370014816 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 573370014817 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573370014818 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 573370014819 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 573370014820 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 573370014821 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 573370014822 Transposase; Region: DDE_Tnp_ISL3; pfam01610 573370014823 Uncharacterized conserved protein [Function unknown]; Region: COG0398 573370014824 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 573370014825 Putative Catalytic site; other site 573370014826 DXD motif; other site 573370014827 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 573370014828 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 573370014829 Ligand binding site; other site 573370014830 Putative Catalytic site; other site 573370014831 DXD motif; other site 573370014832 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 573370014833 B12 binding domain; Region: B12-binding; pfam02310 573370014834 B12-binding domain/radical SAM domain protein, rhizo-twelve system; Region: B12_rSAM_oligo; TIGR04295 573370014835 B12 binding site [chemical binding]; other site 573370014836 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 573370014837 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 573370014838 nudix motif; other site 573370014839 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 573370014840 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 573370014841 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 573370014842 tetramer interface [polypeptide binding]; other site 573370014843 TPP-binding site [chemical binding]; other site 573370014844 heterodimer interface [polypeptide binding]; other site 573370014845 phosphorylation loop region [posttranslational modification] 573370014846 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 573370014847 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 573370014848 alpha subunit interface [polypeptide binding]; other site 573370014849 TPP binding site [chemical binding]; other site 573370014850 heterodimer interface [polypeptide binding]; other site 573370014851 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 573370014852 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 573370014853 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 573370014854 NADP binding site [chemical binding]; other site 573370014855 active site 573370014856 putative substrate binding site [chemical binding]; other site 573370014857 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 573370014858 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 573370014859 inhibitor-cofactor binding pocket; inhibition site 573370014860 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573370014861 catalytic residue [active] 573370014862 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 573370014863 extended (e) SDRs; Region: SDR_e; cd08946 573370014864 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573370014865 NAD(P) binding site [chemical binding]; other site 573370014866 active site 573370014867 substrate binding site [chemical binding]; other site 573370014868 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 573370014869 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 573370014870 Substrate binding site; other site 573370014871 Mg++ binding site; other site 573370014872 metal-binding site 573370014873 Mg++ binding site; other site 573370014874 metal-binding site 573370014875 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 573370014876 Predicted dehydrogenase [General function prediction only]; Region: COG0579 573370014877 hydroxyglutarate oxidase; Provisional; Region: PRK11728; cl19156 573370014878 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 573370014879 dimer interface [polypeptide binding]; other site 573370014880 active site 573370014881 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 573370014882 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573370014883 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 573370014884 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 573370014885 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 573370014886 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573370014887 Helix-turn-helix domain; Region: HTH_17; pfam12728 573370014888 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 573370014889 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 573370014890 catalytic residues [active] 573370014891 catalytic nucleophile [active] 573370014892 Recombinase; Region: Recombinase; pfam07508 573370014893 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 573370014894 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 573370014895 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 573370014896 multiple promoter invertase; Provisional; Region: mpi; PRK13413 573370014897 catalytic residues [active] 573370014898 catalytic nucleophile [active] 573370014899 Presynaptic Site I dimer interface [polypeptide binding]; other site 573370014900 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 573370014901 Synaptic Flat tetramer interface [polypeptide binding]; other site 573370014902 Synaptic Site I dimer interface [polypeptide binding]; other site 573370014903 DNA binding site [nucleotide binding] 573370014904 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569 573370014905 DNA-binding interface [nucleotide binding]; DNA binding site 573370014906 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 573370014907 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 573370014908 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573370014909 active site 573370014910 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 573370014911 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 573370014912 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 573370014913 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 573370014914 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573370014915 P-loop; other site 573370014916 Magnesium ion binding site [ion binding]; other site 573370014917 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 573370014918 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 573370014919 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 573370014920 acyl-activating enzyme (AAE) consensus motif; other site 573370014921 AMP binding site [chemical binding]; other site 573370014922 active site 573370014923 CoA binding site [chemical binding]; other site 573370014924 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573370014925 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051